Is Extremely High Life Satisfaction during Adolescence Advantageous?

ERIC Educational Resources Information Center

Suldo, Shannon M.; Huebner, E. Scott

2006-01-01

This study examined whether extremely high life satisfaction was associated with adaptive functioning or maladaptive functioning. Six hundred ninety-eight secondary level students completed the Students' Life Satisfaction Scale [Huebner, 1991a, School Psychology International, 12, pp. 231-240], Youth Self-Report of the Child Behavior Checklist…

Extremely preterm infants who are small for gestational age have a high risk of early hypophosphatemia and hypokalemia.

PubMed

Boubred, F; Herlenius, E; Bartocci, M; Jonsson, B; Vanpée, M

2015-11-01

Electrolyte balances have not been sufficiently evaluated in extremely preterm infants after early parenteral nutrition. We investigated the risk of early hypophosphatemia and hypokalemia in extremely preterm infants born small for gestational age (SGA) who received nutrition as currently recommended. This prospective, observational cohort study included all consecutive extremely preterm infants born at 24-27 weeks who received high amino acids and lipid perfusion from birth. We evaluated the electrolyte levels of SGA infants and infants born appropriate for gestational age (AGA) during the first five days of life. The 12 SGA infants had lower plasma potassium levels from Day One compared to the 36 AGA infants and were more likely to have hypokalemia (58% vs 17%, p = 0.001) and hypophosphatemia (40% vs 9%, p < 0.01) during the five-day observation period. After adjusting for perinatal factors, SGA remained significantly associated with hypophosphatemia (odds ratio 1.39, confidence intervals 1.07-1.81, p = 0.01). Extremely preterm infants born SGA who were managed with currently recommended early parenteral nutrition had a high risk of early hypokalemia and hypophosphatemia. Potassium and phosphorus intakes should be set at sufficient levels from birth onwards, especially in SGA infants. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Impact of extreme high temperature on mortality and regional level definition of heat wave: a multi-city study in China.

PubMed

Gao, Jinghong; Sun, Yunzong; Liu, Qiyong; Zhou, Maigeng; Lu, Yaogui; Li, Liping

2015-02-01

Few multi-city studies have been conducted to explore the regional level definition of heat wave and examine the association between extreme high temperature and mortality in developing countries. The purpose of the present study was to investigate the impact of extreme high temperature on mortality and to explore the local definition of heat wave in five Chinese cities. We first used a distributed lag non-linear model to characterize the effects of daily mean temperature on non-accidental mortality. We then employed a generalized additive model to explore the city-specific definition of heat wave. Finally, we performed a comparative analysis to evaluate the effectiveness of the definition. For each city, we found a positive non-linear association between extreme high temperature and mortality, with the highest effects appearing within 3 days of extreme heat event onset. Specifically, we defined individual heat waves of Beijing and Tianjin as being two or more consecutive days with daily mean temperatures exceeding 30.2 °C and 29.5 °C, respectively, and Nanjing, Shanghai and Changsha heat waves as ≥3 consecutive days with daily mean temperatures higher than 32.9 °C, 32.3 °C and 34.5 °C, respectively. Comparative analysis generally supported the definition. We found extreme high temperatures were associated with increased mortality, after a short lag period, when temperatures exceeded obvious threshold levels. The city-specific definition of heat wave developed in our study may provide guidance for the establishment and implementation of early heat-health response systems for local government to deal with the projected negative health outcomes due to heat waves. Copyright © 2014 Elsevier B.V. All rights reserved.

Treatment strategy for metastatic prostate cancer with extremely high PSA level: reconsidering the value of vintage therapy.

PubMed

Yamada, Yasutaka; Sakamoto, Shinichi; Amiya, Yoshiyasu; Sasaki, Makoto; Shima, Takayuki; Komiya, Akira; Suzuki, Noriyuki; Akakura, Koichiro; Ichikawa, Tomohiko; Nakatsu, Hiroomi

2018-05-04

The prognostic significance of initial prostate-specific antigen (PSA) level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with metastatic prostate cancer and divided them into three PSA level groups as follows: low (<100 ng ml -1 ), intermediate (100-999 ng ml -1 ), and high (≥1000 ng ml -1 ). All patients received androgen deprivation therapy (ADT) immediately. We investigated PSA progression-free survival (PFS) for first-line ADT and overall survival (OS) within each of the three groups. Furthermore, we analyzed response to antiandrogen withdrawal (AW) and alternative antiandrogen (AA) therapies after development of castration-resistant prostate cancer (CRPC). No significant differences in OS were observed among the three groups (P = 0.654). Patients with high PSA levels had significantly short PFS for first-line ADT (P = 0.037). Conversely, patients in the high PSA level group had significantly longer PFS when treated with AW than those in the low PSA level group (P = 0.047). Furthermore, patients with high PSA levels had significantly longer PFS when provided with AA therapy (P = 0.049). PSA responders to AW and AA therapies had significantly longer survival after CRPC development than nonresponders (P = 0.011 and P < 0.001, respectively). Thus, extremely high PSA level predicted favorable response to vintage sequential ADT and AW. The current data suggest a novel aspect of extremely high PSA value as a favorable prognostic marker after development of CRPC.

Extreme groundwater levels caused by extreme weather conditions - the highest ever measured groundwater levels in Middle Germany and their management

NASA Astrophysics Data System (ADS)

Reinstorf, F.; Kramer, S.; Koch, T.; Pfützner, B.

2017-12-01

Extreme weather conditions during the years 2009 - 2011 in combination with changes in the regional water management led to maximum groundwater levels in large areas of Germany in 2011. This resulted in extensive water logging, with problems especially in urban areas near rivers, where water logging produced huge problems for buildings and infrastructure. The acute situation still exists in many areas and requires the development of solution concepts. Taken the example of the Elbe-Saale-Region in the Federal State of Saxony-Anhalt, were a pilot research project was carried out, the analytical situation, the development of a management tool and the implementation of a groundwater management concept are shown. The central tool is a coupled water budget - groundwater flow model. In combination with sophisticated multi-scale parameter estimation, a high-resolution groundwater level simulation was carried out. A decision support process with an intensive stakeholder interaction combined with high-resolution simulations enables the development of a management concept for extreme groundwater situations in consideration of sustainable and environmentally sound solutions mainly on the base of passive measures.

The balance and harmony of control power for a combat aircraft in tactical maneuvering

NASA Technical Reports Server (NTRS)

Bocvarov, Spiro; Cliff, Eugene M.; Lutze, Frederick H.

1992-01-01

An analysis is presented for a family of regular extremal attitude-maneuvers for the High Angle-of-Attack Research Vehicle that has thrust-vectoring capability. Different levels of dynamic coupling are identified in the combat aircraft attitude model, and the characteristic extremal-family motion is explained. It is shown why the extremal-family trajectories develop small sideslip-angles, a highly desirable feature from a practical viewpoint.

Variability of hydrological extreme events in East Asia and their dynamical control: a comparison between observations and two high-resolution global climate models

NASA Astrophysics Data System (ADS)

Freychet, N.; Duchez, A.; Wu, C.-H.; Chen, C.-A.; Hsu, H.-H.; Hirschi, J.; Forryan, A.; Sinha, B.; New, A. L.; Graham, T.; Andrews, M. B.; Tu, C.-Y.; Lin, S.-J.

2017-02-01

This work investigates the variability of extreme weather events (drought spells, DS15, and daily heavy rainfall, PR99) over East Asia. It particularly focuses on the large scale atmospheric circulation associated with high levels of the occurrence of these extreme events. Two observational datasets (APHRODITE and PERSIANN) are compared with two high-resolution global climate models (HiRAM and HadGEM3-GC2) and an ensemble of other lower resolution climate models from CMIP5. We first evaluate the performance of the high resolution models. They both exhibit good skill in reproducing extreme events, especially when compared with CMIP5 results. Significant differences exist between the two observational datasets, highlighting the difficulty of having a clear estimate of extreme events. The link between the variability of the extremes and the large scale circulation is investigated, on monthly and interannual timescales, using composite and correlation analyses. Both extreme indices DS15 and PR99 are significantly linked to the low level wind intensity over East Asia, i.e. the monsoon circulation. It is also found that DS15 events are strongly linked to the surface temperature over the Siberian region and to the land-sea pressure contrast, while PR99 events are linked to the sea surface temperature anomalies over the West North Pacific. These results illustrate the importance of the monsoon circulation on extremes over East Asia. The dependencies on of the surface temperature over the continent and the sea surface temperature raise the question as to what extent they could affect the occurrence of extremes over tropical regions in future projections.

A Motor Drive Electronics Assembly for Mars Curiosity Rover: An Example of Assembly Qualification for Extreme Environments

NASA Technical Reports Server (NTRS)

Kolawa, Elizabeth; Chen, Yuan; Mojarradi, Mohammad M.; Weber, Carissa Tudryn; Hunter, Don J.

2013-01-01

This paper describes the technology development and infusion of a motor drive electronics assembly for Mars Curiosity Rover under space extreme environments. The technology evaluation and qualification as well as space qualification of the assembly are detailed and summarized. Because of the uncertainty of the technologies operating under the extreme space environments and that a high level reliability was required for this assembly application, both component and assembly board level qualifications were performed.

Assessment and comparison of extreme sea levels and waves during the 2013/14 storm season in two UK coastal regions

NASA Astrophysics Data System (ADS)

Wadey, M. P.; Brown, J. M.; Haigh, I. D.; Dolphin, T.; Wisse, P.

2015-10-01

The extreme sea levels and waves experienced around the UK's coast during the 2013/14 winter caused extensive coastal flooding and damage. Coastal managers seek to place such extremes in relation to the anticipated standards of flood protection, and the long-term recovery of the natural system. In this context, return periods are often used as a form of guidance. This paper provides these levels for the winter storms, and discusses their application to the given data sets for two UK case study sites: Sefton, northwest England, and Suffolk, east England. Tide gauge records and wave buoy data were used to compare the 2013/14 storms with return periods from a national data set, and also joint probabilities of sea level and wave heights were generated, incorporating the recent events. The 2013/14 high waters and waves were extreme due to the number of events, as well as the extremity of the 5 December 2013 "Xaver" storm, which had a high return period at both case study sites. The national-scale impact of this event was due to its coincidence with spring high tide at multiple locations. Given that this event is such an outlier in the joint probability analyses of these observed data sets, and that the season saw several events in close succession, coastal defences appear to have provided a good level of protection. This type of assessment could in the future be recorded alongside defence performance and upgrade. Ideally other variables (e.g. river levels at estuarine locations) would also be included, and with appropriate offsetting for local trends (e.g. mean sea-level rise) so that the storm-driven component of coastal flood events can be determined. This could allow long-term comparison of storm severity, and an assessment of how sea-level rise influences return levels over time, which is important for consideration of coastal resilience in strategic management plans.

Factors determining extreme brain natriuretic peptide elevation.

PubMed

Guglin, Maya; Hourani, Rayan; Pitta, Sridevi

2007-01-01

Brain natriuretic peptide (BNP) level is elevated in heart failure and reflects its severity. It is unknown why some patients have extremely high BNP levels. The authors retrospectively reviewed data on 179 consecutive patients whose BNP levels fell within one of several predetermined ranges: mild elevation, 500 to 1000 pg/mL (n=82); moderate elevation, 2000 to 3000 pg/mL (n=48); and high elevation, 4000 to 20,000 pg/mL (n=49). The statistical analysis was conducted with the unpaired t test and Pearson's correlation coefficient. Adjustments were made for age, sex, and serum creatinine level. Patients with moderate BNP elevation were more symptomatic and had more advanced structural and hemodynamic changes than did patients with lower BNP elevation. Characteristics of the high BNP level group did not differ from those of the moderate BNP level group. Serum creatinine level correlated with BNP level, but neither age nor sex did. High BNP level (4000-20,000 pg/mL) is determined more by renal dysfunction than by the severity of heart failure.

A new framework for estimating return levels using regional frequency analysis

NASA Astrophysics Data System (ADS)

Winter, Hugo; Bernardara, Pietro; Clegg, Georgina

2017-04-01

We propose a new framework for incorporating more spatial and temporal information into the estimation of extreme return levels. Currently, most studies use extreme value models applied to data from a single site; an approach which is inefficient statistically and leads to return level estimates that are less physically realistic. We aim to highlight the benefits that could be obtained by using methodology based upon regional frequency analysis as opposed to classic single site extreme value analysis. This motivates a shift in thinking, which permits the evaluation of local and regional effects and makes use of the wide variety of data that are now available on high temporal and spatial resolutions. The recent winter storms over the UK during the winters of 2013-14 and 2015-16, which have caused wide-ranging disruption and damaged important infrastructure, provide the main motivation for the current work. One of the most impactful natural hazards is flooding, which is often initiated by extreme precipitation. In this presentation, we focus on extreme rainfall, but shall discuss other meteorological variables alongside potentially damaging hazard combinations. To understand the risks posed by extreme precipitation, we need reliable statistical models which can be used to estimate quantities such as the T-year return level, i.e. the level which is expected to be exceeded once every T-years. Extreme value theory provides the main collection of statistical models that can be used to estimate the risks posed by extreme precipitation events. Broadly, at a single site, a statistical model is fitted to exceedances of a high threshold and the model is used to extrapolate to levels beyond the range of the observed data. However, when we have data at many sites over a spatial domain, fitting a separate model for each separate site makes little sense and it would be better if we could incorporate all this information to improve the reliability of return level estimates. Here, we use the regional frequency analysis approach to define homogeneous regions which are affected by the same storms. Extreme value models are then fitted to the data pooled from across a region. We find that this approach leads to more spatially consistent return level estimates with reduced uncertainty bounds.

Climate change impacts on tropical cyclones and extreme sea levels in the South Pacific — A regional assessment

NASA Astrophysics Data System (ADS)

Walsh, Kevin J. E.; McInnes, Kathleen L.; McBride, John L.

2012-01-01

This paper reviews the current understanding of the effect of climate change on extreme sea levels in the South Pacific region. This region contains many locations that are vulnerable to extreme sea levels in the current climate, and projections indicate that this vulnerability will increase in the future. The recent publication of authoritative statements on the relationship between global warming and global sea level rise, tropical cyclones and the El Niño-Southern Oscillation phenomenon has motivated this review. Confident predictions of global mean sea level rise are modified by regional differences in the steric (density-related) component of sea level rise and changing gravitational interactions between the ocean and the ice sheets which affect the regional distribution of the eustatic (mass-related) contribution to sea level rise. The most extreme sea levels in this region are generated by tropical cyclones. The intensity of the strongest tropical cyclones is likely to increase, but many climate models project a substantial decrease in tropical cyclone numbers in this region, which may lead to an overall decrease in the total number of intense tropical cyclones. This projection, however, needs to be better quantified using improved high-resolution climate model simulations of tropical cyclones. Future changes in ENSO may lead to large regional variations in tropical cyclone incidence and sea level rise, but these impacts are also not well constrained. While storm surges from tropical cyclones give the largest sea level extremes in the parts of this region where they occur, other more frequent high sea level events can arise from swell generated by distant storms. Changes in wave climate are projected for the tropical Pacific due to anthropogenically-forced changes in atmospheric circulation. Future changes in sea level extremes will be caused by a combination of changes in mean sea level, regional sea level trends, tropical cyclone incidence and wave climate. Recommendations are given for research to increase understanding of the response of these factors to climate change. Implications of the results for adaptation research are also discussed.

Integrating plant ecological responses to climate extremes from individual to ecosystem levels.

PubMed

Felton, Andrew J; Smith, Melinda D

2017-06-19

Climate extremes will elicit responses from the individual to the ecosystem level. However, only recently have ecologists begun to synthetically assess responses to climate extremes across multiple levels of ecological organization. We review the literature to examine how plant responses vary and interact across levels of organization, focusing on how individual, population and community responses may inform ecosystem-level responses in herbaceous and forest plant communities. We report a high degree of variability at the individual level, and a consequential inconsistency in the translation of individual or population responses to directional changes in community- or ecosystem-level processes. The scaling of individual or population responses to community or ecosystem responses is often predicated upon the functional identity of the species in the community, in particular, the dominant species. Furthermore, the reported stability in plant community composition and functioning with respect to extremes is often driven by processes that operate at the community level, such as species niche partitioning and compensatory responses during or after the event. Future research efforts would benefit from assessing ecological responses across multiple levels of organization, as this will provide both a holistic and mechanistic understanding of ecosystem responses to increasing climatic variability.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

Changing Global Risk Landscape - Challenges for Risk Management (Invited)

NASA Astrophysics Data System (ADS)

Wenzel, F.

2009-12-01

The exponentially growing losses related to natural disasters on a global scale reflect a changing risk landscape that is characterized by the influence of climate change and a growing population, particularly in urban agglomerations and coastal zones. In consequence of these trends we witness (a) new hazards such as landslides due to dwindling permafrost, new patterns of strong precipitation and related floods, potential for tropical cyclones in the Mediterranean, sea level rise and others; (b) new risks related to large numbers of people in very dense urban areas, and risks related to the vulnerability of infrastructure such as energy supply, water supply, transportation, communication, etc. (c) extreme events with unprecedented size and implications. An appropriate answer to these challenges goes beyond classical views of risk assessment and protection. It must include an understanding of risk as changing with time so that risk assessment needs to be supplemented by risk monitoring. It requires decision making under high uncertainty. The risks (i.e. potentials for future losses) of extreme events are not only high but also very difficult to quantify, as they are characterized by high levels of uncertainty. Uncertainties relate to frequency, time of occurrence, strength and impact of extreme events but also to the coping capacities of society in response to them. The characterization, quantification, reduction in the extent possible of the uncertainties is an inherent topic of extreme event research. However, they will not disappear, so a rational approach to extreme events must include more than reducing uncertainties. It requires us to assess and rate the irreducible uncertainties, to evaluate options for mitigation under large uncertainties, and their communication to societal sectors. Thus scientist need to develop methodologies that aim at a rational approach to extreme events associated with high levels of uncertainty.

Sarcoidosis with high serum levels of vascular endothelial growth factor (VEGF), showing RS3PE-like symptoms in extremities.

PubMed

Matsuda, Masayuki; Sakurai, Kumi; Fushimi, Tomohisa; Yamamoto, Kanji; Rokuhara, Shiho; Hosaka, Naritoshi; Ikeda, Shu-ichi

2004-06-01

We report a patient with sarcoidosis who showed edema in the distal portion of all extremities, particularly the legs, as seen in remitting seronegative symmetrical synovitis with pitting edema (RS3PE). Magnetic resonance imaging demonstrated diffuse abnormal intensity in subcutaneous tissues of both legs, and skin biopsy led to a diagnosis of sarcoidosis. Vascular endothelial growth factor (VEGF) showed a high serum level, which decreased soon after starting oral prednisolone, in parallel with an improvement in the limb edema. In this patient VEGF as well as infiltration by sarcoid granuloma in the skin might have played an important role in the pathogenesis of RS3PE-like symptoms in the extremities. When painful pitting edema is seen predominantly in the distal portion of all extremities, sarcoidosis as well as RS3PE should be considered as a possible diagnosis.

Neighbourhood green space, physical function and participation in physical activities among elderly men: the Caerphilly Prospective study

PubMed Central

2014-01-01

Background The built environment in which older people live plays an important role in promoting or inhibiting physical activity. Most work on this complex relationship between physical activity and the environment has excluded people with reduced physical function or ignored the difference between groups with different levels of physical function. This study aims to explore the role of neighbourhood green space in determining levels of participation in physical activity among elderly men with different levels of lower extremity physical function. Method Using data collected from the Caerphilly Prospective Study (CaPS) and green space data collected from high resolution Landmap true colour aerial photography, we first investigated the effect of the quantity of neighbourhood green space and the variation in neighbourhood vegetation on participation in physical activity for 1,010 men aged 66 and over in Caerphilly county borough, Wales, UK. Second, we explored whether neighbourhood green space affects groups with different levels of lower extremity physical function in different ways. Results Increasing percentage of green space within a 400 meters radius buffer around the home was significantly associated with more participation in physical activity after adjusting for lower extremity physical function, psychological distress, general health, car ownership, age group, marital status, social class, education level and other environmental factors (OR = 1.21, 95% CI 1.05, 1.41). A statistically significant interaction between the variation in neighbourhood vegetation and lower extremity physical function was observed (OR = 1.92, 95% CI 1.12, 3.28). Conclusion Elderly men living in neighbourhoods with more green space have higher levels of participation in regular physical activity. The association between variation in neighbourhood vegetation and regular physical activity varied according to lower extremity physical function. Subjects reporting poor lower extremity physical function living in neighbourhoods with more homogeneous vegetation (i.e. low variation) were more likely to participate in regular physical activity than those living in neighbourhoods with less homogeneous vegetation (i.e. high variation). Good lower extremity physical function reduced the adverse effect of high variation vegetation on participation in regular physical activity. This provides a basis for the future development of novel interventions that aim to increase levels of physical activity in later life, and has implications for planning policy to design, preserve, facilitate and encourage the use of green space near home. PMID:24646136

Neighbourhood green space, physical function and participation in physical activities among elderly men: the Caerphilly Prospective study.

PubMed

Gong, Yi; Gallacher, John; Palmer, Stephen; Fone, David

2014-03-19

The built environment in which older people live plays an important role in promoting or inhibiting physical activity. Most work on this complex relationship between physical activity and the environment has excluded people with reduced physical function or ignored the difference between groups with different levels of physical function. This study aims to explore the role of neighbourhood green space in determining levels of participation in physical activity among elderly men with different levels of lower extremity physical function. Using data collected from the Caerphilly Prospective Study (CaPS) and green space data collected from high resolution Landmap true colour aerial photography, we first investigated the effect of the quantity of neighbourhood green space and the variation in neighbourhood vegetation on participation in physical activity for 1,010 men aged 66 and over in Caerphilly county borough, Wales, UK. Second, we explored whether neighbourhood green space affects groups with different levels of lower extremity physical function in different ways. Increasing percentage of green space within a 400 meters radius buffer around the home was significantly associated with more participation in physical activity after adjusting for lower extremity physical function, psychological distress, general health, car ownership, age group, marital status, social class, education level and other environmental factors (OR = 1.21, 95% CI 1.05, 1.41). A statistically significant interaction between the variation in neighbourhood vegetation and lower extremity physical function was observed (OR = 1.92, 95% CI 1.12, 3.28). Elderly men living in neighbourhoods with more green space have higher levels of participation in regular physical activity. The association between variation in neighbourhood vegetation and regular physical activity varied according to lower extremity physical function. Subjects reporting poor lower extremity physical function living in neighbourhoods with more homogeneous vegetation (i.e. low variation) were more likely to participate in regular physical activity than those living in neighbourhoods with less homogeneous vegetation (i.e. high variation). Good lower extremity physical function reduced the adverse effect of high variation vegetation on participation in regular physical activity. This provides a basis for the future development of novel interventions that aim to increase levels of physical activity in later life, and has implications for planning policy to design, preserve, facilitate and encourage the use of green space near home.

Spatio-temporal variations in storm surges along the North Atlantic coasts

NASA Astrophysics Data System (ADS)

Marcos, Marta; Woodworth, Philip

2017-04-01

Extreme sea levels along the coasts of the North Atlantic Ocean and the Gulf of Mexico have been investigated using hourly tide gauge records compiled in the recently released GESLA-2 data set (www.gesla.org). These regions are among the most densely monitored coasts worldwide, with more than 300 high frequency quality-controlled tide gauge time series available. Here we estimate the storm surge component of extreme sea levels using both tidal residuals and skew surges, for which we explore the spatial and temporal coherency of their intensities, duration and frequency. We quantify the relationship of extremes with dominant large scale climate patterns and discuss the impact of mean sea level changes. Finally, we test the assumption of stationarity of the probability of extreme occurrence and to which extent it holds when mean sea level changes are considered in combination with storm surges.

Extreme groundwater levels caused by extreme weather conditions - the highest ever measured groundwater levels in Middle Germany and their management

NASA Astrophysics Data System (ADS)

Reinstorf, F.

2016-12-01

Extreme weather conditions during the years 2009 - 2011 in combination with changes in the regional water management and possible impacts of climate change led to maximum groundwater levels in large areas of Germany in 2011. This resulted in extensive water logging, with problems especially in urban areas near rivers, where water logging produced huge problems for buildings and infrastructure. The acute situation still exists in many areas and requires the development of solution concepts. Taken the example of the Elbe-Saale-Region in the Federal State of Saxony-Anhalt, were a pilot research project was carried out, the analytical situation, the development of a management tool and the implementation of a groundwater management concept are shown. The central tool is a coupled water budget - groundwater flow model. In combination with sophisticated multi-scale parameter estimation, a high resolution groundwater level simulation was carried out. A decision support process with a very intensive stakeholder interaction combined with high resolution simulations enables the development of a management concept for extreme groundwater situations in consideration of sustainable and environmentally sound solutions mainly on the base of passive measures.

Extreme groundwater levels caused by extreme weather conditions - the highest ever measured groundwater levels in Middle Germany and their management

NASA Astrophysics Data System (ADS)

Reinstorf, Frido; Kramer, Stefanie; Koch, Thomas; Seifert, Sven; Monninkhoff, Bertram; Pfützner, Bernd

2017-04-01

Extreme weather conditions during the years 2009 - 2011 in combination with changes in the regional water management and possible impacts of climate change led to maximum groundwater levels in large areas of Germany in 2011. This resulted in extensive water logging, with problems especially in urban areas near rivers, where water logging produced huge problems for buildings and infrastructure. The acute situation still exists in many areas and requires the development of solution concepts. Taken the example of the Elbe-Saale-Region in the Federal State of Saxony-Anhalt, were a pilot research project was carried out, the analytical situation, the development of a management tool and the implementation of a groundwater management concept are shown. The central tool is a coupled water budget - groundwater flow model. In combination with sophisticated multi-scale parameter estimation, a high resolution groundwater level simulation was carried out. A decision support process with a very intensive stakeholder interaction combined with high resolution simulations enables the development of a management concept for extreme groundwater situations in consideration of sustainable and environmentally sound solutions mainly on the base of passive measures.

Seasonal changes in gastric mucosal factors associated with peptic ulcer bleeding.

PubMed

Yuan, Xiao-Gang; Xie, Chuan; Chen, Jiang; Xie, Yong; Zhang, Kun-He; Lu, Nong-Hua

2015-01-01

A close association has been established between climate and peptic ulcer bleeding (PUB). The incidence of PUB in cold climates is significantly higher than that in hot climates. In this study, gastric mucosal damage and its barrier function (through associated barrier factors) in extreme climate conditions were examined to investigate the pathogenesis of PUB in extreme cold climates. Gastric juice and biopsy specimens were collected from 176 patients with peptic ulcer. Conventional hematoxylin and eosin staining was used to exclude malignant ulcers. Helicobacter pylori infections were detected by modified Giemsa staining. pH values of the gastric juice samples were obtained on-site by precise pH dipstick readings. The protein expression levels of heat shock protein (HSP) 70, occludin, nitric oxide synthase (NOS), epidermal growth factor (EGF) and EGF receptor (EGFR) in the gastric mucosa were detected by immunohistochemistry. No significant differences were identified between the high and low bleeding risk groups in the rates of H. pylori infection and the pH values of the gastric juices in the extreme hot or cold climates. Furthermore, no statistically significant differences were identified in the protein expression levels of occludin, NOS, EGF and EGFR between the high and low bleeding risk groups. In the extreme cold climate, the expression of HSP70 and the mucus thickness of the gastric antrum in the high bleeding risk group were significantly lower than those in the low bleeding risk group. The protein expression levels of occludin, HSP70, NOS and EGFR in the extreme cold climate were significantly lower than those in the extreme hot climate, whereas the gastric acid secretion was significantly higher in the extreme cold climate than that in the extreme hot climate. In conclusion, low expression of HSP70 in the gastric mucosa and reduced gastric mucus thickness may play key roles in the mechanism of PUB in extreme cold climates. The significant decrease in barrier factors and increase in damage in extreme cold climates may be associated with the seasonal pattern of peptic ulcers.

Seasonal changes in gastric mucosal factors associated with peptic ulcer bleeding

PubMed Central

YUAN, XIAO-GANG; XIE, CHUAN; CHEN, JIANG; XIE, YONG; ZHANG, KUN-HE; LU, NONG-HUA

2015-01-01

A close association has been established between climate and peptic ulcer bleeding (PUB). The incidence of PUB in cold climates is significantly higher than that in hot climates. In this study, gastric mucosal damage and its barrier function (through associated barrier factors) in extreme climate conditions were examined to investigate the pathogenesis of PUB in extreme cold climates. Gastric juice and biopsy specimens were collected from 176 patients with peptic ulcer. Conventional hematoxylin and eosin staining was used to exclude malignant ulcers. Helicobacter pylori infections were detected by modified Giemsa staining. pH values of the gastric juice samples were obtained on-site by precise pH dipstick readings. The protein expression levels of heat shock protein (HSP) 70, occludin, nitric oxide synthase (NOS), epidermal growth factor (EGF) and EGF receptor (EGFR) in the gastric mucosa were detected by immunohistochemistry. No significant differences were identified between the high and low bleeding risk groups in the rates of H. pylori infection and the pH values of the gastric juices in the extreme hot or cold climates. Furthermore, no statistically significant differences were identified in the protein expression levels of occludin, NOS, EGF and EGFR between the high and low bleeding risk groups. In the extreme cold climate, the expression of HSP70 and the mucus thickness of the gastric antrum in the high bleeding risk group were significantly lower than those in the low bleeding risk group. The protein expression levels of occludin, HSP70, NOS and EGFR in the extreme cold climate were significantly lower than those in the extreme hot climate, whereas the gastric acid secretion was significantly higher in the extreme cold climate than that in the extreme hot climate. In conclusion, low expression of HSP70 in the gastric mucosa and reduced gastric mucus thickness may play key roles in the mechanism of PUB in extreme cold climates. The significant decrease in barrier factors and increase in damage in extreme cold climates may be associated with the seasonal pattern of peptic ulcers. PMID:25452787

Ensemble-based evaluation of extreme water levels for the eastern Baltic Sea

NASA Astrophysics Data System (ADS)

Eelsalu, Maris; Soomere, Tarmo

2016-04-01

The risks and damages associated with coastal flooding that are naturally associated with an increase in the magnitude of extreme storm surges are one of the largest concerns of countries with extensive low-lying nearshore areas. The relevant risks are even more contrast for semi-enclosed water bodies such as the Baltic Sea where subtidal (weekly-scale) variations in the water volume of the sea substantially contribute to the water level and lead to large spreading of projections of future extreme water levels. We explore the options for using large ensembles of projections to more reliably evaluate return periods of extreme water levels. Single projections of the ensemble are constructed by means of fitting several sets of block maxima with various extreme value distributions. The ensemble is based on two simulated data sets produced in the Swedish Meteorological and Hydrological Institute. A hindcast by the Rossby Centre Ocean model is sampled with a resolution of 6 h and a similar hindcast by the circulation model NEMO with a resolution of 1 h. As the annual maxima of water levels in the Baltic Sea are not always uncorrelated, we employ maxima for calendar years and for stormy seasons. As the shape parameter of the Generalised Extreme Value distribution changes its sign and substantially varies in magnitude along the eastern coast of the Baltic Sea, the use of a single distribution for the entire coast is inappropriate. The ensemble involves projections based on the Generalised Extreme Value, Gumbel and Weibull distributions. The parameters of these distributions are evaluated using three different ways: maximum likelihood method and method of moments based on both biased and unbiased estimates. The total number of projections in the ensemble is 40. As some of the resulting estimates contain limited additional information, the members of pairs of projections that are highly correlated are assigned weights 0.6. A comparison of the ensemble-based projection of extreme water levels and their return periods with similar estimates derived from local observations reveals an interesting pattern of match and mismatch. The match is almost perfect in measurement sites where local effects (e.g., wave-induced set-up or local surge in very shallow areas that are not resolved by circulation models) do not contribute to the observed values of water level. There is, however, substantial mismatch between projected and observed extreme values for most of the Estonian coast. The mismatch is largest for sections that are open to high waves and for several bays that are deeply cut into mainland but open for predominant strong wind directions. Detailed quantification of this mismatch eventually makes it possible to develop substantially improved estimates of extreme water levels in sections where local effects considerably contribute into the total water level.

Pituitary, gonadal and adrenal hormones after prolonged residence at extreme altitude in man.

PubMed

Basu, M; Pal, K; Prasad, R; Malhotra, A S; Rao, K S; Sawhney, R C

1997-06-01

High altitude-induced alterations in pituitary, gonadal and adrenal hormones were studied in (i) eugonadal men from the armed forces who were resident at sea level (SL), (ii) SL residents staying at an altitude of 3542 m for periods ranging from 3 to 12 months (acclimatized lowlanders, ALL), (iii) ALL who stayed at 6300 m for 6 months, (iv) ALL who trekked from 3542 to 5080 m and stayed at an altitude of more than 6300 m in the glacier region for 6 months, and (v) high-altitude natives (HAN) resident at an altitude of 3300-3700 m. Circulating levels of LH, FSH, prolactin, cortisol, testosterone, dihydrotestosterone (DHT) and progesterone in ALL at 3542 m and in HAN were not significantly different (p > 0.05) from the SL control values. When the ALL living at 3542 m trekked to an extreme altitude of 5080 m, their testosterone levels showed a significant decrease (p < 0.01) compared to the preceding altitude values but had returned to SL values when measured after 6 months' continuous stay at 6300 m. As with testosterone, the levels of DHT and oestradiol-17 beta (E2) after prolonged stay at extreme altitude were also not significantly different (p > 0.05) from the SL values. The LH levels after trekking to 5080 m were significantly higher (p < 0.01) than at an altitude of 3542 m, but decreased to levels found at 3542 m or SL after prolonged residence at extreme altitude. Plasma levels of ACTH, prolactin, FSH and cortisol on arrival at 5080 m, and after a 6-month stay at extreme altitude, were not significantly different (p > 0.05) from the SL values. Plasma progesterone levels tended to increase on arrival at 5080 m but a significant increase (p < 0.001) was evident only after a 6-month stay at extreme altitude. These observations suggest that prolonged residence at lower as well as at extreme altitude does not appreciably alter blood levels of pituitary, gonadal or adrenal hormones except for plasma levels of progesterone. The exact mechanism and significance of this increase remains unknown, but may be important in increasing the sensitivity of the hypoxic ventilatory response and activation of haemoglobin synthesis.

Quantifying the role of climate variability on extreme total water level impacts: An application of a full simulation model to Ocean Beach, California

NASA Astrophysics Data System (ADS)

Serafin, K.; Ruggiero, P.; Stockdon, H. F.; Barnard, P.; Long, J.

2014-12-01

Many coastal communities worldwide are vulnerable to flooding and erosion driven by extreme total water levels (TWL), potentially dangerous events produced by the combination of large waves, high tides, and high non-tidal residuals. The West coast of the United States provides an especially challenging environment to model these processes due to its complex geological setting combined with uncertain forecasts for sea level rise (SLR), changes in storminess, and possible changes in the frequency of major El Niños. Our research therefore aims to develop an appropriate methodology to assess present-day and future storm-induced coastal hazards along the entire U.S. West coast, filling this information gap. We present the application of this framework in a pilot study at Ocean Beach, California, a National Park site within the Golden Gate National Recreation Area where existing event-scale coastal change data can be used for model calibration and verification. We use a probabilistic, full simulation TWL model (TWL-FSM; Serafin and Ruggiero, in press) that captures the seasonal and interannual climatic variability in extremes using functions of regional climate indices, such as the Multivariate ENSO index (MEI), to represent atmospheric patterns related to the El Niño-Southern Oscillation (ENSO). In order to characterize the effect of climate variability on TWL components, we refine the TWL-FSM by splitting non-tidal residuals into low (monthly mean sea level anomalies) and high frequency (storm surge) components. We also develop synthetic climate indices using Markov sequences to reproduce the autocorrelated nature of ENSO behavior. With the refined TWL-FSM, we simulate each TWL component, resulting in synthetic TWL records providing robust estimates of extreme return level events (e.g., the 100-yr event) and the ability to examine the relative contribution of each TWL component to these extreme events. Extreme return levels are then used to drive storm impact models to examine the probability of coastal change (Stockdon et al., 2013) and thus, the vulnerability to storm-induced coastal hazards that Ocean Beach faces. Future climate variability is easily incorporated into this framework, allowing us to quantify how an evolving climate will alter future extreme TWLs and their related coastal impacts.

Increasing extreme water level flood risk as a result of future sea-level rise: A case study on a coastal city in China

NASA Astrophysics Data System (ADS)

Feng, A.; Wu, S.

2016-12-01

Extreme water levels, caused by the joint occurrence of storm surges and high tides, always lead to super floods along coastlines. In the context of climate change, this study explored the impact of future sea-level rise on the flood risk of extreme water levels. Using Rongcheng City in Shandong Province, China as a case study, flooded area, expected direct damage losses, and affected population and GDP were assessed for 2050 and 2100 under three greenhouse gas concentration Representative Concentration Pathways (RCP) scenarios, 2.6, 4.5, and 8.5. Results indicate that, as a result of sea-level rise induced by climate change, the flooded areas of Rongcheng City would increase by 3.23% to 10.64% in 2050 and by as much as 4.98% to 19.87% in 2100, compared with current recurrence periods. Residential land and farmland are at greatest risk of flooding in terms of exposure and losses than other land-use types, and under a high degree RCP 8.5 scenario, expected damage losses would be between 59.84 billion and 86.45 billion in 2050. Results show that the increase in total direct damage losses would reach an average of 60% in 2100 as a result of a 0.82 m sea-level rise. Similarly, affected population and GDP would increase by between 4.95% and 13.87% and between 3.66% and 10.95% in 2050, and by as much as 7.69% to 29.01% and 5.30% to 20.50% in 2100. This study shows that sea-level rise significantly shortens recurrence periods of extreme water levels, makes extreme flood events more frequent, and exacerbates the risk of future flooding. Our results suggest that, if there is no adaptation, sea-level rise will greatly increase the risk of flooding and severely impact human habitability along coastlines.

Extreme High-Temperature Events Over East Asia in 1.5°C and 2°C Warmer Futures: Analysis of NCAR CESM Low-Warming Experiments

NASA Astrophysics Data System (ADS)

Li, Donghuan; Zhou, Tianjun; Zou, Liwei; Zhang, Wenxia; Zhang, Lixia

2018-02-01

Extreme high-temperature events have large socioeconomic and human health impacts. East Asia (EA) is a populous region, and it is crucial to assess the changes in extreme high-temperature events in this region under different climate change scenarios. The Community Earth System Model low-warming experiment data were applied to investigate the changes in the mean and extreme high temperatures in EA under 1.5°C and 2°C warming conditions above preindustrial levels. The results show that the magnitude of warming in EA is approximately 0.2°C higher than the global mean. Most populous subregions, including eastern China, the Korean Peninsula, and Japan, will see more intense, more frequent, and longer-lasting extreme temperature events under 1.5°C and 2°C warming. The 0.5°C lower warming will help avoid 35%-46% of the increases in extreme high-temperature events in terms of intensity, frequency, and duration in EA with maximal avoidance values (37%-49%) occurring in Mongolia. Thus, it is beneficial for EA to limit the warming target to 1.5°C rather than 2°C.

Publications | Energy Systems Integration Facility | NREL

Science.gov Websites

100% Renewable Grid: Operating Electric Power Systems with Extremely High Levels of Variable Renewable timeline. Feeder Voltage Regulation with High-Penetration PV Using Advanced Inverters and a Distribution Integrating High Levels of Variable Renewable Energy into Electric Power Systems, Journal of Modern Power

Litter Decomposition in Low and High Mortality Northern Red Oak Stands on Extremely Acidic Southwestern Pennsylvania Soils

Treesearch

Michael C. Demchik; William E. Sharpe

2004-01-01

Previous research has shown that decomposition of organic matter is slower in soils with high levels of soil acidity and available aluminum (Al). The objective of this experiment was to determine if differences in decomposition rates of northern red oak leaves occurred between extremely acidic and less acidic sites that also differed in oak mortality. Leaf litter from...

A nonstationary analysis for the Northern Adriatic extreme sea levels

NASA Astrophysics Data System (ADS)

Masina, Marinella; Lamberti, Alberto

2013-09-01

The historical data from the Trieste, Venice, Porto Corsini, and Rimini tide gauges have been used to investigate the spatial and temporal changes in extreme high water levels in the Northern Adriatic. A detailed analysis of annual mean sea level evolution at the three longest operating stations shows a coherent behavior both on a regional and global scale. A slight increase in magnitude of extreme water elevations, after the removal of the regularized annual mean sea level necessary to eliminate the effect of local subsidence and sea level rise, is found at the Venice and Porto Corsini stations. It seems to be mainly associated with a wind regime change occurred in the 1990s, due to an intensification of Bora wind events after their decrease in frequency and intensity during the second half of the 20th century. The extreme values, adjusted for the annual mean sea level trend, are modeled using a time-dependent GEV distribution. The inclusion of seasonality in the GEV parameters considerably improves the data fitting. The interannual fluctuations of the detrended monthly maxima exhibit a significant correlation with the variability of the large-scale atmospheric circulation represented by the North Atlantic Oscillation and Arctic Oscillation indices. The different coast exposure to the Bora and Sirocco winds and their seasonal character explain the various seasonal patterns of extreme sea levels observed at the tide gauges considered in the present analysis.

Trends in body mass index and prevalence of extreme high obesity among Pennsylvania children and adolescents, 2007-2011: promising but cautionary.

PubMed

Lohrmann, David; YoussefAgha, Ahmed; Jayawardene, Wasantha

2014-04-01

We determined current trends and patterns in overweight, obesity, and extreme high obesity among Pennsylvania pre-kindergarten (pre-K) to 12th grade students and simulated future trends. We analyzed body mass index (BMI) of pre-K to 12th grade students from 43 of 67 Pennsylvania counties in 2007 to 2011 to determine trends and to discern transition patterns among BMI status categories for 2009 to 2011. Vinsem simulation, confirmed by Markov chain modeling, generated future prevalence trends. Combined rates of overweight, obesity, and extreme high obesity decreased among secondary school students across the 5 years, and among elementary students, first increased and then markedly decreased. BMI status remained constant for approximately 80% of normal and extreme high obese students, but both decreased and increased among students who initially were overweight and obese; the increase in BMI remained significant. Overall trends in child and adolescent BMI status seemed positive. BMI transition patterns indicated that although overweight and obesity prevalence leveled off, extreme high obesity, especially among elementary students, is projected to increase substantially over time. If current transition patterns continue, the prevalence of overweight, obesity, and extreme high obesity among Pennsylvania students in 2031 is projected to be 16.0%, 6.6%, and 23.2%, respectively.

Characterization of Low Noise, Precision Voltage Reference REF5025-HT Under Extreme Temperatures

NASA Technical Reports Server (NTRS)

Patterson, Richard; Hammoud, Ahmad

2010-01-01

The performance of Texas Instruments precision voltage reference REF5025-HT was assessed under extreme temperatures. This low noise, 2.5 V output chip is suitable for use in high temperature down-hole drilling applications, but no data existed on its performance at cryogenic temperatures. The device was characterized in terms of output voltage and supply current at different input voltage levels as a function of temperature between +210 C and -190 C. Line and load regulation characteristics were also established at six load levels and at different temperatures. Restart capability at extreme temperatures and the effects of thermal cycling, covering the test temperature range, on its operation and stability were also investigated. Under no load condition, the voltage reference chip exhibited good stability in its output over the temperature range of -50 C to +200 C. Outside that temperature range, output voltage did change as temperature was changed. For example, at the extreme temperatures of +210 C and - 190 C, the output level dropped to 2.43 V and 2.32 V, respectively as compared to the nominal value of 2.5 V. At cryogenic test temperatures of -100 C and -150 C the output voltage dropped by about 20%. The quiescent supply current of the voltage reference varied slightly with temperature but remained close to its specified value. In terms of line regulation, the device exhibited excellent stability between -50 C and +150 C over the entire input voltage range and load levels. At the other test temperatures, however, while line regulation became poor at cryogenic temperatures of -100 C and below, it suffered slight degradation at the extreme high temperature but only at the high load level of 10 mA. The voltage reference also exhibited very good load regulation with temperature down to -100 C, but its output dropped sharply at +210 C only at the heavy load of 10 mA. The semiconductor chip was able restart at the extreme temperatures of -190 C and +210 C, and the limited thermal cycling did not influence its characteristics and had no impact on its packaging as no structural or physical damage was observed.

The shouted voice: A pilot study of laryngeal physiology under extreme aerodynamic pressure.

PubMed

Lagier, Aude; Legou, Thierry; Galant, Camille; Amy de La Bretèque, Benoit; Meynadier, Yohann; Giovanni, Antoine

2017-12-01

The objective was to study the behavior of the larynx during shouted voice production, when the larynx is exposed to extremely high subglottic pressure. The study involved electroglottographic, acoustic, and aerodynamic analyses of shouts produced at maximum effort by three male participants. Under a normal speaking voice, the voice sound pressure level (SPL) is proportional to the subglottic pressure. However, when the subglottic pressure reached high levels, the voice SPL reached a maximum value and then decreased as subglottic pressure increased further. Furthermore, the electroglottographic signal sometimes lost its periodicity during the shout, suggesting irregular vocal fold vibration.

Exploring high power, extreme wavelength operating potential of rare-earth-doped silica fiber

NASA Astrophysics Data System (ADS)

Zhou, Pu; Li, Ruixian; Xiao, Hu; Huang, Long; Zhang, Hanwei; Leng, Jinyong; Chen, Zilun; Xu, Jiangmin; Wu, Jian; Wang, Xiong

2017-08-01

Ytterbium-doped fiber laser (YDFL) and Thulium doped fiber laser (TDFL) have been two kinds of the most widely studied fiber laser in recent years. Although both silica-based Ytterbium-doped fiber and Thulium doped fiber have wide emission spectrum band (more than 200 nm and 400 nm, respectively), the operation spectrum region of previously demonstrated high power YDFL and TDFL fall into 1060-1100 nm and 1900-2050nm. Power scaling of YDFL and TDFL operates at short-wavelength or long-wavelength band, especially for extreme wavelength operation, although is highly required in a large variety of application fields, is quite challenging due to small net gain and strong amplified spontaneous emission (ASE). In this paper, we will present study on extreme wavelength operation of high power YDFL and TDFL in our group. Comprehensive mathematical models are built to investigate the feasibility of high power operation and propose effective technical methods to achieve high power operation. We have achieved (1) Diodepumped 1150nm long wavelength YDFL with 120-watt level output power (2) Diode-pumped 1178nm long wavelength YDFL operates at high temperature with 30-watt level output power (3) Random laser pumped 2153nm long wavelength TDFL with 20-watt level output power (4) Diode-pumped 1018nm short wavelength YDFL with a record 2 kilowatt output power is achieved by using home-made fiber combiner.

Assessment and comparison of extreme sea levels and waves during the 2013/2014 storm season in two UK coastal regions

NASA Astrophysics Data System (ADS)

Wadey, M. P.; Brown, J. M.; Haigh, I. D.; Dolphin, T.; Wisse, P.

2015-04-01

The extreme sea levels and waves experienced around the UK's coast during the 2013/2014 winter caused extensive coastal flooding and damage. In such circumstances, coastal managers seek to place such extremes in relation to the anticipated standards of flood protection, and the long-term recovery of the natural system. In this context, return periods are often used as a form of guidance. We therefore provide these levels for the winter storms, as well as discussing their application to the given data sets and case studies (two UK case study sites: Sefton, northwest England; and Suffolk, east England). We use tide gauge records and wave buoy data to compare the 2013/2014 storms with return periods from a national dataset, and also generate joint probabilities of sea level and waves, incorporating the recent events. The UK was hit at a national scale by the 2013/2014 storms, although the return periods differ with location. We also note that the 2013/2014 high water and waves were extreme due to the number of events, as well as the extremity of the 5 December 2013 "Xaver" storm, which had a very high return period at both case study sites. Our return period analysis shows that the national scale impact of this event is due to its coincidence with spring high tide at multiple locations as the tide and storm propagated across the continental shelf. Given that this event is such an outlier in the joint probability analyses of these observed data sets, and that the season saw several events in close succession, coastal defences appear to have provided a good level of protection. This type of assessment should be recorded alongside details of defence performance and upgrade, with other variables (e.g. river levels at estuarine locations) included and appropriate offsetting for linear trends (e.g. mean sea level rise) so that the storm-driven component of coastal flood events can be determined. Local offsetting of the mean trends in sea level allows long-term comparison of storm severity and also enables an assessment of how sea level rise is influencing return levels over time, which is important when considering long-term coastal resilience in strategic management plans.

The magnitude of elevated maternal serum human chorionic gonadotropin and pregnancy complications.

PubMed

Sharony, Reuven; Zipper, Oren; Amichay, Keren; Wiser, Amir; Kidron, Debora; Biron-Shental, Tal; Maymon, Ron

2017-07-01

This study assessed the correlation between the magnitude of the elevation in maternal serum human chorionic gonadotropin (MShCG) levels and pregnancy complications. Among 80,716 screened pregnancies, 120 with moderately elevated MShCG (3.00-5.99 MoM) were compared to 84 with extremely elevated MShCG >6.00 MoM. A control series of 120 women with normal MShCG (<3.00 MoM) were matched. Rates of intrauterine growth restriction, preterm labour, antepartum foetal death (APFD), pre-eclampsia, and placental abruption were analysed. We found that the study group had more adverse outcomes than the control group (73/204 [36%] vs. 18/120 [15%]; p < .0001). The rate was higher in the extremely elevated group than in the moderately elevated group (43/84 [51%] vs. 30/120 [25%]; p < .0001). All 12 cases of APFD (14%) occurred among the extremely elevated series. In conclusion, adverse pregnancy outcomes are more common in women with extremely elevated MShCG. The patients should receive counselling regarding this trend and undergo close pregnancy monitoring. Impact statement • What is already known on this subject?In addition to its contribution to Down syndrome (DS) screening, maternal serum human chorionic gonadotropin (MShCG) levels are a marker for pregnancy complications such as intrauterine growth restriction (IUGR), preterm labour (PTL), antepartum fatal death (APFD), pre-eclampsia (PE), placental abruption (PA) and fetal malformations with or without chromosomal aberrations. • What the results of this study add? We found that in the presence of elevated MShCG levels, the incidence of IUGR and PTL increased. PE increased clinically, but statistical significance was seen only when MShCG was extremely elevated (≥ 6.00 MoM). APFD and PA were associated with very high MShCG levels only. • What the implications are of these findings for clinical practice and/or further research? Women with high MShCG levels should be counselled. In case of very high levels (≥ 6.00 MoM), the risk of APFD and PA should be discussed. The pregnancy should be monitored for IUGR, PTL and PE. In view of the limited number of enrolled patients with very high levels of MShCG, the experience of other institutions is needed to corroborate these findings.

Global coastal flood hazard mapping

NASA Astrophysics Data System (ADS)

Eilander, Dirk; Winsemius, Hessel; Ward, Philip; Diaz Loaiza, Andres; Haag, Arjen; Verlaan, Martin; Luo, Tianyi

2017-04-01

Over 10% of the world's population lives in low-lying coastal areas (up to 10m elevation). Many of these areas are prone to flooding from tropical storm surges or extra-tropical high sea levels in combination with high tides. A 1 in 100 year extreme sea level is estimated to expose 270 million people and 13 trillion USD worth of assets to flooding. Coastal flood risk is expected to increase due to drivers such as ground subsidence, intensification of tropical and extra-tropical storms, sea level rise and socio-economic development. For better understanding of the hazard and drivers to global coastal flood risk, a globally consistent analysis of coastal flooding is required. In this contribution we present a comprehensive global coastal flood hazard mapping study. Coastal flooding is estimated using a modular inundation routine, based on a vegetation corrected SRTM elevation model and forced by extreme sea levels. Per tile, either a simple GIS inundation routine or a hydrodynamic model can be selected. The GIS inundation method projects extreme sea levels to land, taking into account physical obstructions and dampening of the surge level land inwards. For coastlines with steep slopes or where local dynamics play a minor role in flood behavior, this fast GIS method can be applied. Extreme sea levels are derived from the Global Tide and Surge Reanalysis (GTSR) dataset. Future sea level projections are based on probabilistic sea level rise for RCP 4.5 and RCP 8.5 scenarios. The approach is validated against observed flood extents from ground and satellite observations. The results will be made available through the online Aqueduct Global Flood Risk Analyzer of the World Resources Institute.

Trends in Water Level and Flooding in Dhaka, Bangladesh and Their Impact on Mortality

PubMed Central

Thiele-Eich, Insa; Burkart, Katrin; Simmer, Clemens

2015-01-01

Climate change is expected to impact flooding in many highly populated coastal regions, including Dhaka (Bangladesh), which is currently among the fastest growing cities in the world. In the past, high mortality counts have been associated with extreme flood events. We first analyzed daily water levels of the past 100 years in order to detect potential shifts in extremes. A distributed lag non-linear model was then used to examine the connection between water levels and mortality. Results indicate that for the period of 2003–2007, which entails two major flood events in 2004 and 2007, high water levels do not lead to a significant increase in relative mortality, which indicates a good level of adaptation and capacity to cope with flooding. However, following low water levels, an increase in mortality could be found. As our trend analysis of past water levels shows that minimum water levels have decreased during the past 100 years, action should be taken to ensure that the exposed population is also well-adapted to drought. PMID:25648177

Using Biweight M-Estimates in the Two-Sample Problem. 1. Symmetric Populations

DTIC Science & Technology

1982-01-01

to a Student’s t distribution, across a broad range of a - levels . To be conservative, we might wish to approximate "t" by a Student’s t on nine-tenths...n-i0). While the robustness of classical procedures for extreme a - levels has not been investigated, a comparison with the values in Lee and...D’Agostino (1976) indicates that this procedure is highly robust of validity at a - .05, presumably this robustness extends to the extreme a - levels as well

Assessing Flood Risk Under Sea Level Rise and Extreme Sea Levels Scenarios: Application to the Ebro Delta (Spain)

NASA Astrophysics Data System (ADS)

Sayol, J. M.; Marcos, M.

2018-02-01

This study presents a novel methodology to estimate the impact of local sea level rise and extreme surges and waves in coastal areas under climate change scenarios. The methodology is applied to the Ebro Delta, a valuable and vulnerable low-lying wetland located in the northwestern Mediterranean Sea. Projections of local sea level accounting for all contributions to mean sea level changes, including thermal expansion, dynamic changes, fresh water addition and glacial isostatic adjustment, have been obtained from regionalized sea level projections during the 21st century. Particular attention has been paid to the uncertainties, which have been derived from the spread of the multi-model ensemble combined with seasonal/inter-annual sea level variability from local tide gauge observations. Besides vertical land movements have also been integrated to estimate local relative sea level rise. On the other hand, regional projections over the Mediterranean basin of storm surges and wind-waves have been used to evaluate changes in extreme events. The compound effects of surges and extreme waves have been quantified using their joint probability distributions. Finally, offshore sea level projections from extreme events superimposed to mean sea level have been propagated onto a high resolution digital elevation model of the study region in order to construct flood hazards maps for mid and end of the 21st century and under two different climate change scenarios. The effect of each contribution has been evaluated in terms of percentage of the area exposed to coastal hazards, which will help to design more efficient protection and adaptation measures.

Life at extreme elevations on Atacama volcanoes: the closest thing to Mars on Earth?

PubMed

Schmidt, S K; Gendron, E M S; Vincent, K; Solon, A J; Sommers, P; Schubert, Z R; Vimercati, L; Porazinska, D L; Darcy, J L; Sowell, P

2018-03-20

Here we describe recent breakthroughs in our understanding of microbial life in dry volcanic tephra ("soil") that covers much of the surface area of the highest elevation volcanoes on Earth. Dry tephra above 6000 m.a.s.l. is perhaps the best Earth analog for the surface of Mars because these "soils" are acidic, extremely oligotrophic, exposed to a thin atmosphere, high UV fluxes, and extreme temperature fluctuations across the freezing point. The simple microbial communities found in these extreme sites have among the lowest alpha diversity of any known earthly ecosystem and contain bacteria and eukaryotes that are uniquely adapted to these extreme conditions. The most abundant eukaryotic organism across the highest elevation sites is a Naganishia species that is metabolically versatile, can withstand high levels of UV radiation and can grow at sub-zero temperatures, and during extreme diurnal freeze-thaw cycles (e.g. - 10 to + 30 °C). The most abundant bacterial phylotype at the highest dry sites sampled (6330 m.a.s.l. on Volcán Llullaillaco) belongs to the enigmatic B12-WMSP1 clade which is related to the Ktedonobacter/Thermosporothrix clade that includes versatile organisms with the largest known bacterial genomes. Close relatives of B12-WMSP1 are also found in fumarolic soils on Volcán Socompa and in oligotrophic, fumarolic caves on Mt. Erebus in Antarctica. In contrast to the extremely low diversity of dry tephra, fumaroles found at over 6000 m.a.s.l. on Volcán Socompa support very diverse microbial communities with alpha diversity levels rivalling those of low elevation temperate soils. Overall, the high-elevation biome of the Atacama region provides perhaps the best "natural experiment" in which to study microbial life in both its most extreme setting (dry tephra) and in one of its least extreme settings (fumarolic soils).

Predictions of extreme precipitation and sea-level rise under climate change.

PubMed

Senior, C A; Jones, R G; Lowe, J A; Durman, C F; Hudson, D

2002-07-15

Two aspects of global climate change are particularly relevant to river and coastal flooding: changes in extreme precipitation and changes in sea level. In this paper we summarize the relevant findings of the IPCC Third Assessment Report and illustrate some of the common results found by the current generation of coupled atmosphere-ocean general circulation models (AOGCMs), using the Hadley Centre models. Projections of changes in extreme precipitation, sea-level rise and storm surges affecting the UK will be shown from the Hadley Centre regional models and the Proudman Oceanographic Laboratory storm-surge model. A common finding from AOGCMs is that in a warmer climate the intensity of precipitation will increase due to a more intense hydrological cycle. This leads to reduced return periods (i.e. more frequent occurrences) of extreme precipitation in many locations. The Hadley Centre regional model simulates reduced return periods of extreme precipitation in a number of flood-sensitive areas of the UK. In addition, simulated changes in storminess and a rise in average sea level around the UK lead to reduced return periods of extreme high coastal water events. The confidence in all these results is limited by poor spatial resolution in global coupled models and by uncertainties in the physical processes in both global and regional models, and is specific to the climate change scenario used.

Overparenting and Homework: The Student's Task, but Everyone's Responsibility

ERIC Educational Resources Information Center

Locke, Judith Y.; Kavanagh, David J.; Campbell, Marilyn A.

2016-01-01

A high level of parental involvement is widely considered to be essential for optimal child and adolescent development and wellbeing, including academic success. However, recent consideration has been given to the idea that extremely high levels of parental involvement (often called "overparenting" or "helicopter parenting")…

Violent Extremism, National Security and Prevention. Institutional Discourses and Their Implications for Schooling

ERIC Educational Resources Information Center

Mattsson, Christer; Säljö, Roger

2018-01-01

Currently, threats to societal security from extremist groups are high on the political agenda in many countries. Politicians, policymakers at various levels and communities are searching for methods to counteract recruitment to violent organizations. These efforts are often referred to as Prevention of Violent Extremism (PVE-programmes). One of…

Identification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels.

PubMed

Bandarian, Fatemeh; Daneshpour, Maryam Sadat; Hedayati, Mehdi; Naseri, Mohsen; Azizi, Fereidoun

2016-01-01

Apolipoprotein A2 (APOA2) is the second major apolipoprotein of the high-density lipoprotein cholesterol (HDL-C). The study aim was to identify APOA2 gene variation in individuals within two extreme tails of HDL-C levels and its relationship with HDL-C level. This cross-sectional survey was conducted on participants from Tehran Glucose and Lipid Study (TLGS) at Research Institute for Endocrine Sciences, Tehran, Iran from April 2012 to February 2013. In total, 79 individuals with extreme low HDL-C levels (≤5th percentile for age and gender) and 63 individuals with extreme high HDL-C levels (≥95th percentile for age and gender) were selected. Variants were identified using DNA amplification and direct sequencing. Screen of all exons and the core promoter region of APOA2 gene identified nine single nucleotide substitutions and one microsatellite; five of which were known and four were new variants. Of these nine variants, two were common tag single nucleotide polymorphisms (SNPs) and seven were rare SNPs. Both exonic substitutions were missense mutations and caused an amino acid change. There was a significant association between the new missense mutation (variant Chr.1:16119226, Ala98Pro) and HDL-C level. None of two common tag SNPs of rs6413453 and rs5082 contributes to the HDL-C trait in Iranian population, but a new missense mutation in APOA2 in our population has a significant association with HDL-C.

A review of statistical methods to analyze extreme precipitation and temperature events in the Mediterranean region

NASA Astrophysics Data System (ADS)

Lazoglou, Georgia; Anagnostopoulou, Christina; Tolika, Konstantia; Kolyva-Machera, Fotini

2018-04-01

The increasing trend of the intensity and frequency of temperature and precipitation extremes during the past decades has substantial environmental and socioeconomic impacts. Thus, the objective of the present study is the comparison of several statistical methods of the extreme value theory (EVT) in order to identify which is the most appropriate to analyze the behavior of the extreme precipitation, and high and low temperature events, in the Mediterranean region. The extremes choice was made using both the block maxima and the peaks over threshold (POT) technique and as a consequence both the generalized extreme value (GEV) and generalized Pareto distributions (GPDs) were used to fit them. The results were compared, in order to select the most appropriate distribution for extremes characterization. Moreover, this study evaluates the maximum likelihood estimation, the L-moments and the Bayesian method, based on both graphical and statistical goodness-of-fit tests. It was revealed that the GPD can characterize accurately both precipitation and temperature extreme events. Additionally, GEV distribution with the Bayesian method is proven to be appropriate especially for the greatest values of extremes. Another important objective of this investigation was the estimation of the precipitation and temperature return levels for three return periods (50, 100, and 150 years) classifying the data into groups with similar characteristics. Finally, the return level values were estimated with both GEV and GPD and with the three different estimation methods, revealing that the selected method can affect the return level values for both the parameter of precipitation and temperature.

Projected regional changes in the characteristics of dry and moist heat waves in the United States derived from downscaled CMIP5 models

NASA Astrophysics Data System (ADS)

Schoof, J. T.

2017-12-01

Extreme temperatures affect society in multiple ways, but the impacts are often different depending on the concurrent humidity. For example, the greatest impacts on human morbidity and mortality result when the temperature and humidity are both elevated. Conversely, high temperatures coupled with low humidity often lead to agricultural impacts resulting in lower yields. Despite the importance of humidity in determining heat wave impacts, relatively few students of future temperature extremes have also considered possible changes in humidity. In a recent study, we investigated recent historical changes in the frequency and intensity and low humidity and high humidity extreme temperature events using a framework based on isobaric equivalent temperature. Here, we extend this approach to climate projections from CMIP5 models to explore possible regional changes in extreme heat characteristics. After using quantile mapping to bias correct and downscale the CMIP5 model outputs, we analyze results from two future periods (2031-2055 and 2061-2085) and two representative concentration pathways, RCP 4.5 and RCP 8.5, corresponding to moderate and high levels of radiative forcing from greenhouse gases. For each of seven US regions, we consider changes in extreme temperature frequency, changes in the proportion of extreme temperature days characterized by high humidity, and changes in the magnitude of temperature and humidity on extreme temperature days.

Extreme Water Levels in Bangladesh: Past Trends, Future Projections and their Impact on Mortality

NASA Astrophysics Data System (ADS)

Thiele-Eich, I.; Burkart, K.; Hopson, T. M.; Simmer, C.

2014-12-01

Climate change is expected to have an impact on meteorological and therefore hydrological extremes, thereby possibly altering the vulnerability of exposed populations. Our study focuses on Bangladesh, which is particularly vulnerable to changes in extremes due to both the large population at risk, as well as geographical characteristics such as the low-rising slope of the country through which the outflow of the combined catchments of the Ganges, Brahmaputra and Meghna rivers (GBM, ~1.75 million km2) is channeled.Time series of daily discharge and water level data for the past 100 years were analyzed with respect to trends in frequency, magnitude and duration, focusing on rare but particularly high-risk events using extreme-value theory. Mortality data is available for a five-year period (2003-2007), with a distributed lag non-linear model used to examine possible connections between extreme water levels and mortality. Then, using output from the Community Climate System Model CCSM4, projections were made regarding future flooding due to changes in precipitation intensity and frequency, while also accounting for the backwater effect of sea-level rise. For this, the upper catchment precipitation as well as monthly mean thermosteric sea-level rise at the river mouth outflow were taken from the four CCSM4 1° 20th Century ensemble members as well as from six CCSM4 1° ensemble members for the RCP scenarios RCP 2.6, 4.5, 6.0 and 8.5.Results show that while e.g. the mean water level did not significantly rise during the past 100 years, a change in extreme water levels can be detected. In addition, annual minimum water levels have decreased, which is of particular importance as there is a significant connection to an increase in mortality for low water levels. While mortality does not seem to increase significantly due to extreme floods, our results indicate that return levels projected for the future shift progressively, with the effect being strongest for RCP 8.5. Further measures to strengthen the resilience of the exposed population are therefore required to ensure that climate change effects do not overwhelm the population's coping capacities.

Polygenic determinants in extremes of high-density lipoprotein cholesterol[S

PubMed Central

Dron, Jacqueline S.; Wang, Jian; Low-Kam, Cécile; Khetarpal, Sumeet A.; Robinson, John F.; McIntyre, Adam D.; Ban, Matthew R.; Cao, Henian; Rhainds, David; Dubé, Marie-Pierre; Rader, Daniel J.; Lettre, Guillaume; Tardif, Jean-Claude

2017-01-01

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 unrelated lipid clinic patients with extreme HDL-C levels, we used a targeted next-generation sequencing panel to evaluate rare variants in known HDL metabolism genes, simultaneously with common variants bundled into a polygenic trait score. Two additional cohorts were used for validation and included 1,746 individuals from the Montréal Heart Institute Biobank and 1,048 individuals from the University of Pennsylvania. Findings were consistent between cohorts: we found rare heterozygous large-effect variants in 18.7% and 10.9% of low- and high-HDL-C patients, respectively. We also found common variant accumulation, indicated by extreme polygenic trait scores, in an additional 12.8% and 19.3% of overall cases of low- and high-HDL-C extremes, respectively. Thus, the genetic basis of extreme HDL-C concentrations encountered clinically is frequently polygenic, with contributions from both rare large-effect and common small-effect variants. Multiple types of genetic variants should be considered as contributing factors in patients with extreme dyslipidemia. PMID:28870971

Polygenic determinants in extremes of high-density lipoprotein cholesterol.

PubMed

Dron, Jacqueline S; Wang, Jian; Low-Kam, Cécile; Khetarpal, Sumeet A; Robinson, John F; McIntyre, Adam D; Ban, Matthew R; Cao, Henian; Rhainds, David; Dubé, Marie-Pierre; Rader, Daniel J; Lettre, Guillaume; Tardif, Jean-Claude; Hegele, Robert A

2017-11-01

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 unrelated lipid clinic patients with extreme HDL-C levels, we used a targeted next-generation sequencing panel to evaluate rare variants in known HDL metabolism genes, simultaneously with common variants bundled into a polygenic trait score. Two additional cohorts were used for validation and included 1,746 individuals from the Montréal Heart Institute Biobank and 1,048 individuals from the University of Pennsylvania. Findings were consistent between cohorts: we found rare heterozygous large-effect variants in 18.7% and 10.9% of low- and high-HDL-C patients, respectively. We also found common variant accumulation, indicated by extreme polygenic trait scores, in an additional 12.8% and 19.3% of overall cases of low- and high-HDL-C extremes, respectively. Thus, the genetic basis of extreme HDL-C concentrations encountered clinically is frequently polygenic, with contributions from both rare large-effect and common small-effect variants. Multiple types of genetic variants should be considered as contributing factors in patients with extreme dyslipidemia. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

Australian climate extremes at 1.5 °C and 2 °C of global warming

NASA Astrophysics Data System (ADS)

King, Andrew D.; Karoly, David J.; Henley, Benjamin J.

2017-06-01

To avoid more severe impacts from climate change, there is international agreement to strive to limit warming to below 1.5 °C. However, there is a lack of literature assessing climate change at 1.5 °C and the potential benefits in terms of reduced frequency of extreme events. Here, we demonstrate that existing model simulations provide a basis for rapid and rigorous analysis of the effects of different levels of warming on large-scale climate extremes, using Australia as a case study. We show that limiting warming to 1.5 °C, relative to 2 °C, would perceptibly reduce the frequency of extreme heat events in Australia. The Australian continent experiences a variety of high-impact climate extremes that result in loss of life, and economic and environmental damage. Events similar to the record-hot summer of 2012-2013 and warm seas associated with bleaching of the Great Barrier Reef in 2016 would be substantially less likely, by about 25% in both cases, if warming is kept to lower levels. The benefits of limiting warming on hydrometeorological extremes are less clear. This study provides a framework for analysing climate extremes at 1.5 °C global warming.

Dialogue on Climate, Water, Energy and Human Security in Africa

DTIC Science & Technology

2014-07-01

winter periods.  The influence of the  ocean  mass on the coastal areas can be seen, with slightly lower increases in  average temperatures.       Figure 1...adaptation 1 1’ ~ + -foradaptllion m \\...A..AJ to reduce risk .... :’\\: " -••• \\ Warming Extreme Extreme Damaging Ocean Sea surface I Precipitation Sea...level Risk level with Risk level with trend temperature precipitation cyclone acidification temperature high adaptation cuJTentadaptation Institutions

Impacts of Extreme Events on Human Health. Chapter 4

NASA Technical Reports Server (NTRS)

Bell, Jesse E.; Herring, Stephanie C.; Jantarasami, Lesley; Adrianopoli, Carl; Benedict, Kaitlin; Conlon, Kathryn; Escobar, Vanessa; Hess, Jeremy; Luvall, Jeffrey; Garcia-Pando, Carlos Perez;

Modelling the increased frequency of extreme sea levels in the Ganges-Brahmaputra-Meghna delta due to sea level rise and other effects of climate change.

PubMed

Kay, S; Caesar, J; Wolf, J; Bricheno, L; Nicholls, R J; Saiful Islam, A K M; Haque, A; Pardaens, A; Lowe, J A

2015-07-01

Coastal flooding due to storm surge and high tides is a serious risk for inhabitants of the Ganges-Brahmaputra-Meghna (GBM) delta, as much of the land is close to sea level. Climate change could lead to large areas of land being subject to increased flooding, salinization and ultimate abandonment in West Bengal, India, and Bangladesh. IPCC 5th assessment modelling of sea level rise and estimates of subsidence rates from the EU IMPACT2C project suggest that sea level in the GBM delta region may rise by 0.63 to 0.88 m by 2090, with some studies suggesting this could be up to 0.5 m higher if potential substantial melting of the West Antarctic ice sheet is included. These sea level rise scenarios lead to increased frequency of high water coastal events. Any effect of climate change on the frequency and severity of storms can also have an effect on extreme sea levels. A shelf-sea model of the Bay of Bengal has been used to investigate how the combined effect of sea level rise and changes in other environmental conditions under climate change may alter the frequency of extreme sea level events for the period 1971 to 2099. The model was forced using atmospheric and oceanic boundary conditions derived from climate model projections and the future scenario increase in sea level was applied at its ocean boundary. The model results show an increased likelihood of extreme sea level events through the 21st century, with the frequency of events increasing greatly in the second half of the century: water levels that occurred at decadal time intervals under present-day model conditions occurred in most years by the middle of the 21st century and 3-15 times per year by 2100. The heights of the most extreme events tend to increase more in the first half of the century than the second. The modelled scenarios provide a case study of how sea level rise and other effects of climate change may combine to produce a greatly increased threat to life and property in the GBM delta by the end of this century.

The Influence of Wheelchair Propulsion Hand Pattern on Upper Extremity Muscle Power and Stress

PubMed Central

Slowik, Jonathan S.; Requejo, Philip S.; Mulroy, Sara J.; Neptune, Richard R.

2016-01-01

The hand pattern (i.e., full-cycle hand path) used during manual wheelchair propulsion is frequently classified as one of four distinct hand pattern types: arc, single loop, double loop and semicircular. Current clinical guidelines recommend the use of the semicircular pattern, which is based on advantageous levels of broad biomechanical metrics implicitly related to the demand placed on the upper extremity (e.g., lower cadence). However, an understanding of the influence of hand pattern on specific measures of upper extremity muscle demand (e.g., muscle power and stress) is needed to help make such recommendations, but these quantities are difficult and impractical to measure experimentally. The purpose of this study was to use musculoskeletal modeling and forward dynamics simulations to investigate the influence of the hand pattern used on specific measures of upper extremity muscle demand. The simulation results suggest that the double loop and semicircular patterns produce the most favorable levels of overall muscle stress and total muscle power. The double loop pattern had the lowest full-cycle and recovery-phase upper extremity demand but required high levels of muscle power during the relatively short contact phase. The semicircular pattern had the second-lowest full-cycle levels of overall muscle stress and total muscle power, and demand was more evenly distributed between the contact and recovery phases. These results suggest that in order to decrease upper extremity demand, manual wheelchair users should use either the double loop or semicircular pattern when propelling their wheelchairs at a self-selected speed on level ground. PMID:27062591

Synthesis of knowledge of extreme fire behavior: volume I for fire managers

Treesearch

Paul A. Werth; Brian E. Potter; Craig B. Clements; Mark A. Finney; Scott L. Goodrick; Martin E. Alexander; Miguel G. Cruz; Jason A. Forthofer; Sara S. McAllister

2011-01-01

The National Wildfire Coordinating Group definition of extreme fire behavior (EFB) indicates a level of fire behavior characteristics that ordinarily precludes methods of direct control action. One or more of the following is usually involved: high rate of spread, prolific crowning/spotting, presence of fire whirls, and strong convection column. Predictability is...

Extreme value modeling for the analysis and prediction of time series of extreme tropospheric ozone levels: a case study.

PubMed

Escarela, Gabriel

2012-06-01

The occurrence of high concentrations of tropospheric ozone is considered as one of the most important issues of air management programs. The prediction of dangerous ozone levels for the public health and the environment, along with the assessment of air quality control programs aimed at reducing their severity, is of considerable interest to the scientific community and to policy makers. The chemical mechanisms of tropospheric ozone formation are complex, and highly variable meteorological conditions contribute additionally to difficulties in accurate study and prediction of high levels of ozone. Statistical methods offer an effective approach to understand the problem and eventually improve the ability to predict maximum levels of ozone. In this paper an extreme value model is developed to study data sets that consist of periodically collected maxima of tropospheric ozone concentrations and meteorological variables. The methods are applied to daily tropospheric ozone maxima in Guadalajara City, Mexico, for the period January 1997 to December 2006. The model adjusts the daily rate of change in ozone for concurrent impacts of seasonality and present and past meteorological conditions, which include surface temperature, wind speed, wind direction, relative humidity, and ozone. The results indicate that trend, annual effects, and key meteorological variables along with some interactions explain the variation in daily ozone maxima. Prediction performance assessments yield reasonably good results.

Successful treatment of extreme acute lead intoxication.

PubMed

Mikler, J; Banovcin, P; Jesenak, M; Hamzikova, J; Statelova, D

2009-03-01

Severe acute lead intoxications are rare and are associated with accidental or purposeful ingestion. There were only few cases of severe to fatal poisonings reported in literature in children. We report a case of acute lead intoxication in a child with extremely high lead blood level of 20.4 micromol/L (422.7 microg/dL), who was treated with chelation and in whom significant organ dysfunction did not develop. Documented significant high level above 3.37 micromol/L (corresponding to 70 microg/dL) in this patient persisted for approximately 24 h. Adequate, single or combined chelatation therapy in early phase of acute lead poisoning is essential for the further patient's outcome.

Hybrid photonic signal processing

NASA Astrophysics Data System (ADS)

Ghauri, Farzan Naseer

This thesis proposes research of novel hybrid photonic signal processing systems in the areas of optical communications, test and measurement, RF signal processing and extreme environment optical sensors. It will be shown that use of innovative hybrid techniques allows design of photonic signal processing systems with superior performance parameters and enhanced capabilities. These applications can be divided into domains of analog-digital hybrid signal processing applications and free-space---fiber-coupled hybrid optical sensors. The analog-digital hybrid signal processing applications include a high-performance analog-digital hybrid MEMS variable optical attenuator that can simultaneously provide high dynamic range as well as high resolution attenuation controls; an analog-digital hybrid MEMS beam profiler that allows high-power watt-level laser beam profiling and also provides both submicron-level high resolution and wide area profiling coverage; and all optical transversal RF filters that operate on the principle of broadband optical spectral control using MEMS and/or Acousto-Optic tunable Filters (AOTF) devices which can provide continuous, digital or hybrid signal time delay and weight selection. The hybrid optical sensors presented in the thesis are extreme environment pressure sensors and dual temperature-pressure sensors. The sensors employ hybrid free-space and fiber-coupled techniques for remotely monitoring a system under simultaneous extremely high temperatures and pressures.

An application of extreme value theory to the management of a hydroelectric dam.

PubMed

Minkah, Richard

2016-01-01

Assessing the probability of very low or high water levels is an important issue in the management of hydroelectric dams. In the case of the Akosombo dam, very low and high water levels result in load shedding of electrical power and flooding in communities downstream respectively. In this paper, we use extreme value theory to estimate the probability and return period of very low water levels that can result in load shedding or a complete shutdown of the dam's operations. In addition, we assess the probability and return period of high water levels near the height of the dam and beyond. This provides a framework for a possible extension of the dam to sustain the generation of electrical power and reduce the frequency of spillage that causes flooding in communities downstream. The results show that an extension of the dam can reduce the probability and prolong the return period of a flood. In addition, we found a negligible probability of a complete shutdown of the dam due to inadequate water level.

An interhemispheric tropical sea level seesaw due to El Niño Taimasa

NASA Astrophysics Data System (ADS)

Widlansky, M. J.; Timmermann, A.; McGregor, S.; Stuecker, M. F.; Cai, W.

2013-12-01

During strong El Niño events, sea level drops around some tropical western Pacific islands by up to 20-30 cm. Such extreme events (referred to as ';taimasa' in Samoa) expose shallow reefs, thereby damaging associated coastal ecosystems and contributing to the formation of ';flat topped coral heads' often referred to as microatolls. We show that during the termination of strong El Niño events, a southward movement of weak trade winds and development of an anomalous anticyclone in the Philippine Sea force an interhemispheric sea level seesaw in the tropical Pacific which enhances and prolongs extreme low sea levels in the southwestern Pacific. Spectral features, in addition to wind forced linear shallow water ocean model experiments, identify an interaction between El Niño and the annual cycle as the main cause of these sea level anomalies. Given the well established seasonal prediction skill for El Niño events and their seasonally paced termination, our analysis suggests that long-duration extreme sea level drops may also be highly predictable.

A perturbation approach for assessing trends in precipitation extremes across Iran

NASA Astrophysics Data System (ADS)

Tabari, Hossein; AghaKouchak, Amir; Willems, Patrick

2014-11-01

Extreme precipitation events have attracted a great deal of attention among the scientific community because of their devastating consequences on human livelihood and socio-economic development. To assess changes in precipitation extremes in a given region, it is essential to analyze decadal oscillations in precipitation extremes. This study examines temporal oscillations in precipitation data in several sub-regions of Iran using a novel quantile perturbation method during 1980-2010. Precipitation data from NASA's Modern-Era Retrospective Analysis for Research and Applications-Land (MERRA-Land) are used in this study. The results indicate significant anomalies in precipitation extremes in the northwest and southeast regions of Iran. Analysis of extreme precipitation perturbations reveals that perturbations for the monthly aggregation level are generally lower than the annual perturbations. Furthermore, high-oscillation and low-oscillation periods are found in extreme precipitation quantiles across different seasons. In all selected regions, a significant anomaly (i.e., extreme wet/dry conditions) in precipitation extremes is observed during spring.

DRINKING WATER ARSENIC EXPOSURE AND BLOOD PRESSURE IN HEALTHY WOMEN OF REPRODUCTIVE AGE IN INNER MONGOLIA, CHINA

EPA Science Inventory

The extremely high exposure levels evaluated in prior investigations relating elevated levels of drinking water arsenic and hypertension prevalence make extrapolation to potential vascular effects at lower exposure levels very difficult. A cross-sectional study was conducted on ...

Identification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels

PubMed Central

Bandarian, Fatemeh; Daneshpour, Maryam Sadat; Hedayati, Mehdi; Naseri, Mohsen; Azizi, Fereidoun

2016-01-01

Background: Apolipoprotein A2 (APOA2) is the second major apolipoprotein of the high-density lipoprotein cholesterol (HDL-C). The study aim was to identify APOA2 gene variation in individuals within two extreme tails of HDL-C levels and its relationship with HDL-C level. Methods: This cross-sectional survey was conducted on participants from Tehran Glucose and Lipid Study (TLGS) at Research Institute for Endocrine Sciences, Tehran, Iran from April 2012 to February 2013. In total, 79 individuals with extreme low HDL-C levels (≤5th percentile for age and gender) and 63 individuals with extreme high HDL-C levels (≥95th percentile for age and gender) were selected. Variants were identified using DNA amplification and direct sequencing. Results: Screen of all exons and the core promoter region of APOA2 gene identified nine single nucleotide substitutions and one microsatellite; five of which were known and four were new variants. Of these nine variants, two were common tag single nucleotide polymorphisms (SNPs) and seven were rare SNPs. Both exonic substitutions were missense mutations and caused an amino acid change. There was a significant association between the new missense mutation (variant Chr.1:16119226, Ala98Pro) and HDL-C level. Conclusion: None of two common tag SNPs of rs6413453 and rs5082 contributes to the HDL-C trait in Iranian population, but a new missense mutation in APOA2 in our population has a significant association with HDL-C. PMID:26590203

Scenario dependence of future changes in climate extremes under 1.5 °C and 2 °C global warming

NASA Astrophysics Data System (ADS)

Wang, Zhili; Lin, Lei; Zhang, Xiaoye; Zhang, Hua; Liu, Liangke; Xu, Yangyang

2017-04-01

The 2015 Paris Agreement aims to limit global warming below 2 °C and pursue efforts to even limit it to 1.5 °C relative to pre-industrial levels. Decision makers need reliable information on the impacts caused by these warming levels for climate mitigation and adaptation measures. We explore the changes in climate extremes, which are closely tied to economic losses and casualties, under 1.5 °C and 2 °C global warming and their scenario dependence using three sets of ensemble global climate model simulations. A warming of 0.5 °C (from 1.5 °C to 2 °C) leads to significant increases in temperature and precipitation extremes in most regions. However, the projected changes in climate extremes under both warming levels highly depend on the pathways of emissions scenarios, with different greenhouse gas (GHG)/aerosol forcing ratio and GHG levels. Moreover, there are multifold differences in several heavily polluted regions, among the scenarios, in the changes in precipitation extremes due to an additional 0.5 °C warming from 1.5 °C to 2 °C. Our results demonstrate that the chemical compositions of emissions scenarios, not just the total radiative forcing and resultant warming level, must be considered when assessing the impacts of global 1.5/2 °C warming.

Scenario dependence of future changes in climate extremes under 1.5 °C and 2 °C global warming.

PubMed

Wang, Zhili; Lin, Lei; Zhang, Xiaoye; Zhang, Hua; Liu, Liangke; Xu, Yangyang

2017-04-20

The 2015 Paris Agreement aims to limit global warming below 2 °C and pursue efforts to even limit it to 1.5 °C relative to pre-industrial levels. Decision makers need reliable information on the impacts caused by these warming levels for climate mitigation and adaptation measures. We explore the changes in climate extremes, which are closely tied to economic losses and casualties, under 1.5 °C and 2 °C global warming and their scenario dependence using three sets of ensemble global climate model simulations. A warming of 0.5 °C (from 1.5 °C to 2 °C) leads to significant increases in temperature and precipitation extremes in most regions. However, the projected changes in climate extremes under both warming levels highly depend on the pathways of emissions scenarios, with different greenhouse gas (GHG)/aerosol forcing ratio and GHG levels. Moreover, there are multifold differences in several heavily polluted regions, among the scenarios, in the changes in precipitation extremes due to an additional 0.5 °C warming from 1.5 °C to 2 °C. Our results demonstrate that the chemical compositions of emissions scenarios, not just the total radiative forcing and resultant warming level, must be considered when assessing the impacts of global 1.5/2 °C warming.

Scenario dependence of future changes in climate extremes under 1.5 °C and 2 °C global warming

PubMed Central

Wang, Zhili; Lin, Lei; Zhang, Xiaoye; Zhang, Hua; Liu, Liangke; Xu, Yangyang

2017-01-01

The 2015 Paris Agreement aims to limit global warming below 2 °C and pursue efforts to even limit it to 1.5 °C relative to pre-industrial levels. Decision makers need reliable information on the impacts caused by these warming levels for climate mitigation and adaptation measures. We explore the changes in climate extremes, which are closely tied to economic losses and casualties, under 1.5 °C and 2 °C global warming and their scenario dependence using three sets of ensemble global climate model simulations. A warming of 0.5 °C (from 1.5 °C to 2 °C) leads to significant increases in temperature and precipitation extremes in most regions. However, the projected changes in climate extremes under both warming levels highly depend on the pathways of emissions scenarios, with different greenhouse gas (GHG)/aerosol forcing ratio and GHG levels. Moreover, there are multifold differences in several heavily polluted regions, among the scenarios, in the changes in precipitation extremes due to an additional 0.5 °C warming from 1.5 °C to 2 °C. Our results demonstrate that the chemical compositions of emissions scenarios, not just the total radiative forcing and resultant warming level, must be considered when assessing the impacts of global 1.5/2 °C warming. PMID:28425445

Vulnerability of global food production to extreme climatic events.

PubMed

Yeni, F; Alpas, H

2017-06-01

It is known that the frequency, intensity or duration of the extreme climatic events have been changing substantially. The ultimate goal of this study was to identify current vulnerabilities of global primary food production against extreme climatic events, and to discuss potential entry points for adaptation planning by means of an explorative vulnerability analysis. Outcomes of this analysis were demonstrated as a composite index where 118 country performances in maintaining safety of food production were compared and ranked against climate change. In order to better interpret the results, cluster analysis technique was used as a tool to group the countries based on their vulnerability index (VI) scores. Results suggested that one sixth of the countries analyzed were subject to high level of exposure (0.45-1), one third to high to very high level of sensitivity (0.41-1) and low to moderate level of adaptive capacity (0-0.59). Proper adaptation strategies for reducing the microbial and chemical contamination of food products, soil and waters on the field were proposed. Finally, availability of data on food safety management systems and occurrence of foodborne outbreaks with global coverage were proposed as key factors for improving the robustness of future vulnerability assessments. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Statistical Tool for Examining Heat Waves and Other Extreme Phenomena Arising from Multiple Factors

NASA Astrophysics Data System (ADS)

Cooley, D. S.; Castillo, F.; Thibaud, E.

2017-12-01

A 2015 heatwave in Pakistan is blamed for over a thousand deaths. This event consisted of several days of very high temperatures and unusually high humidity for this region. However, none of these days exceeded the threshold for "extreme danger" in terms of the heat index. The heat index is a univariate function of both temperature and humidity which is universally applied at all locations regardless of local climate. Understanding extremes which arise from multiple factors is challenging. In this paper we will present a tool for examining bivariate extreme behavior. The tool, developed in the statistical software R, draws isolines of equal exceedance probability. These isolines can be understood as bivariate "return levels". The tool is based on a dependence framework specific for extremes, is semiparametric, and is able to extrapolate isolines beyond the range of the data. We illustrate this tool using the Pakistan heat wave data and other bivariate data.

Patterns of gun deaths across US counties 1999-2013.

PubMed

Kalesan, Bindu; Galea, Sandro

2017-05-01

We examined the socio-demographic distribution of gun deaths across 3143 counties in 50 United States' states to understand the spatial patterns and correlates of high and low gun deaths. We used aggregate counts of gun deaths and population in all counties from 1999 to 2013 from the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (WONDER). We characterized four levels of gun violence, as distinct levels of gun death rates of relatively safe, unsafe, violent, and extremely violent counties, based on quartiles of 15-year county-specific gun death rates per 100,000 and used negative binomial regression models allowing clustering by state to calculate incidence rate ratios and 95% confidence intervals (95% CIs). Most states had at least one violent or extremely violent county. Extremely violent gun counties were mostly rural, poor, predominantly minority, had high unemployment rate and homicide rate. Overall, homicide rate was significantly associated with gun deaths (incidence rate ratios = 1.08, 95% CI = 1.06-1.09). In relatively safe counties, this risk was 1.09 (95% CI = 1.05-1.13) and in extremely violent gun counties was 1.03 (95% CI = 1.03-1.04). There are broad differences in gun death rates across the United States representing different levels of gun death rates in each state with distinct socio-demographic profiles. Copyright © 2017 Elsevier Inc. All rights reserved.

Visuo-Spatial Processing in Autism--Testing the Predictions of Extreme Male Brain Theory

ERIC Educational Resources Information Center

Falter, Christine M.; Plaisted, Kate C.; Davis, Greg

2008-01-01

It has been hypothesised that autism is an extreme version of the male brain, caused by high levels of prenatal testosterone (Baron-Cohen 1999). To test this proposal, associations were assessed between three visuo-spatial tasks and prenatal testosterone, indexed in second-to-fourth digit length ratios (2D:4D). The study included children with…

Synthesis of knowledge of extreme fire behavior: volume 2 for fire behavior specialists, researchers, and meteorologists

Treesearch

Paul A. Werth; Brian E. Potter; Martin E. Alexander; Craig B. Clements; Miguel G. Cruz; Mark A. Finney; Jason M. Forthofer; Scott L. Goodrick; Chad Hoffman; W. Matt Jolly; Sara S. McAllister; Roger D. Ottmar; Russell A. Parsons

2016-01-01

The National Wildfire Coordinating Group’s definition of extreme fire behavior indicates a level of fire behavior characteristics that ordinarily precludes methods of direct control action. One or more of the following is usually involved: high rate of spread, prolific crowning/ spotting, presence of fire whirls, and strong convection column. Predictability is...

Adopted Adolescents' Preoccupation with Adoption: The Impact on Adoptive Family Relationships.

ERIC Educational Resources Information Center

Kohler, Julie K.; Grotevant, Harold D.; McRoy, Ruth G.

2002-01-01

Examines relationship between intensity of adopted adolescents' thinking about their adoptions and their adoptive family relationships in 135 adopted adolescents. Adolescents with extremely high levels of preoccupation reported significantly higher levels of alienation and significantly lower levels of trust for their adoptive mothers and fathers.…

Potential Risk Assessment of Mountain Torrent Disasters on Sloping Fields in China

NASA Astrophysics Data System (ADS)

GAO, X.

2017-12-01

China's sloping fields have the problems of low production and serious soil erosion, and mountain torrent disasters will bring more serious soil and water loss to traditional extensive exploitation of sloping field resources. In this paper, China's sloping fields were classified into three grades, such as slightly steep, steep and very steep grade. According to the geological hazards prevention and control regulation, the historical data of China's mountain torrent disasters were spatially interpolated and divided into five classes, such as extremely low, low, middle, high and extremely high level. And the risk level map of mountain torrents was finished in ArcGIS. By using overlaying analysis on sloping fields and risk level map, the potential risk regionalization map of sloping fields in various slope grades was obtained finally. The results shows that the very steep and steep sloping fields are mainly distributed in the first or second stage terraces in China. With the increase of hazard risk level, the area of sloping fields decreases rapidly and the sloping fields in extremely low and low risk levels of mountain torrents reach 98.9%. With the increase of slope grade, the area of sloping fields in various risk levels also declines sharply. The sloping fields take up approximately 60 65% and 26 30% in slightly steep and steep grade areas separately at different risk level. The risk regionalization map can provide effective information for returning farmland to forests or grassland and reducing water and soil erosion of sloping fields in the future.

Why do people buy dogs with potential welfare problems related to extreme conformation and inherited disease? A representative study of Danish owners of four small dog breeds

PubMed Central

Kondrup, S. V.; Bennett, P. C.; Forkman, B.; Meyer, I; Proschowsky, H. F.; Serpell, J. A.; Lund, T. B.

2017-01-01

A number of dog breeds suffer from welfare problems due to extreme phenotypes and high levels of inherited diseases but the popularity of such breeds is not declining. Using a survey of owners of two popular breeds with extreme physical features (French Bulldog and Chihuahua), one with a high load of inherited diseases not directly related to conformation (Cavalier King Charles Spaniel), and one representing the same size range but without extreme conformation and with the same level of disease as the overall dog population (Cairn Terrier), we investigated this seeming paradox. We examined planning and motivational factors behind acquisition of the dogs, and whether levels of experienced health and behavior problems were associated with the quality of the owner-dog relationship and the intention to re-procure a dog of the same breed. Owners of each of the four breeds (750/breed) were randomly drawn from a nationwide Danish dog registry and invited to participate. Of these, 911 responded, giving a final sample of 846. There were clear differences between owners of the four breeds with respect to degree of planning prior to purchase, with owners of Chihuahuas exhibiting less. Motivations behind choice of dog were also different. Health and other breed attributes were more important to owners of Cairn Terriers, whereas the dog’s personality was reported to be more important for owners of French Bulldogs and Cavalier King Charles Spaniels but less important for Chihuahua owners. Higher levels of health and behavior problems were positively associated with a closer owner-dog relationship for owners of Cavalier King Charles Spaniels and Chihuahuas but, for owners of French Bulldogs, high levels of problems were negatively associated with an intention to procure the same breed again. In light of these findings, it appears less paradoxical that people continue to buy dogs with welfare problems. PMID:28234931

Why do people buy dogs with potential welfare problems related to extreme conformation and inherited disease? A representative study of Danish owners of four small dog breeds.

PubMed

Sandøe, P; Kondrup, S V; Bennett, P C; Forkman, B; Meyer, I; Proschowsky, H F; Serpell, J A; Lund, T B

2017-01-01

A number of dog breeds suffer from welfare problems due to extreme phenotypes and high levels of inherited diseases but the popularity of such breeds is not declining. Using a survey of owners of two popular breeds with extreme physical features (French Bulldog and Chihuahua), one with a high load of inherited diseases not directly related to conformation (Cavalier King Charles Spaniel), and one representing the same size range but without extreme conformation and with the same level of disease as the overall dog population (Cairn Terrier), we investigated this seeming paradox. We examined planning and motivational factors behind acquisition of the dogs, and whether levels of experienced health and behavior problems were associated with the quality of the owner-dog relationship and the intention to re-procure a dog of the same breed. Owners of each of the four breeds (750/breed) were randomly drawn from a nationwide Danish dog registry and invited to participate. Of these, 911 responded, giving a final sample of 846. There were clear differences between owners of the four breeds with respect to degree of planning prior to purchase, with owners of Chihuahuas exhibiting less. Motivations behind choice of dog were also different. Health and other breed attributes were more important to owners of Cairn Terriers, whereas the dog's personality was reported to be more important for owners of French Bulldogs and Cavalier King Charles Spaniels but less important for Chihuahua owners. Higher levels of health and behavior problems were positively associated with a closer owner-dog relationship for owners of Cavalier King Charles Spaniels and Chihuahuas but, for owners of French Bulldogs, high levels of problems were negatively associated with an intention to procure the same breed again. In light of these findings, it appears less paradoxical that people continue to buy dogs with welfare problems.

Exposure to extremely low frequency electromagnetic fields alters the behaviour, physiology and stress protein levels of desert locusts

PubMed Central

Wyszkowska, Joanna; Shepherd, Sebastian; Sharkh, Suleiman; Jackson, Christopher W.; Newland, Philip L.

2016-01-01

Electromagnetic fields (EMFs) are present throughout the modern world and are derived from many man-made sources including overhead transmission lines. The risks of extremely-low frequency (ELF) electromagnetic fields are particularly poorly understood especially at high field strengths as they are rarely encountered at ground level. Flying insects, however, can approach close to high field strength transmission lines prompting the question as to how these high levels of exposure affect behaviour and physiology. Here we utilise the accessible nervous system of the locust to ask how exposure to high levels of ELF EMF impact at multiple levels. We show that exposure to ELF EMFs above 4 mT leads to reduced walking. Moreover, intracellular recordings from an identified motor neuron, the fast extensor tibiae motor neuron, show increased spike latency and a broadening of its spike in exposed animals. In addition, hind leg kick force, produced by stimulating the extensor tibiae muscle, was reduced following exposure, while stress-protein levels (Hsp70) increased. Together these results suggest that ELF EMF exposure has the capacity to cause dramatic effects from behaviour to physiology and protein expression, and this study lays the foundation to explore the ecological significance of these effects in other flying insects. PMID:27808167

Towards a full representation of tropical cyclones in a global reanalysis of extreme sea levels

NASA Astrophysics Data System (ADS)

Muis, S.; Verlaan, M.; Lin, N.; Winsemius, H.; Vatvani, D.; Ward, P.; Aerts, J.

2016-12-01

Tropical cyclones (TCs), including hurricanes and typhoons, are characterised by high wind speeds and low pressure, and cause dangerous storm surges in coastal areas. Recent disasters like the flooding of New Orleans in 2005 due to Hurricane Katrina and of New York in 2012 due to Hurricane Sandy exemplify the significant TC risk in the United States. In this contribution, we present a new framework to model TC storm surges and probabilities at the Atlantic basin- and, ultimately, global scales. This works builds on the work of Muis et al. (2016), which presented the first dynamically-derived reanalysis dataset of storm surges that covers the entire world's coastline (GTSR dataset). Surge levels for the period 1979-2014 were simulated by forcing the Global Surge and Tide Model (GTSM) with wind speed and atmospheric pressure from the ERA-Interim reanalysis. There is generally a good agreement between simulated and observed sea level extremes in extra-tropical regions; however for areas prone to TCs there is a severe underestimation of extremes. For example, the maximum surge levels during Hurricane Katrina in New Orleans exceeded 8 m, whilst the GTSM surge levels in that area do not exceed 2-3 m. Hence, due to the coarse grid resolution, the strong intensities of TCs are not fully captured in ERA-Interim. Furthermore, the length of ERA-Interim data set, like other reanalysis datasets, is too short to estimate the probabilities of extreme TC events in a reliable way. For accurate risk assessments it is essential to improve the representation of TCs in these global reanalysis of extreme sea levels. First, we need a higher resolution of meteorological forcing, which can be modelled with input from the observed best track data. Second, we need to statistically extend the observed record to many thousands of years. We will present the first results of these steps for the east coast of the United States. We will validate the GTSM model forced with best track data using recent extreme events like Katrina and Sandy. We will investigate how the statistics of the extreme sea level will change due to improved representation of TCs.

Laser waveform control of extreme ultraviolet high harmonics from solids.

PubMed

You, Yong Sing; Wu, Mengxi; Yin, Yanchun; Chew, Andrew; Ren, Xiaoming; Gholam-Mirzaei, Shima; Browne, Dana A; Chini, Michael; Chang, Zenghu; Schafer, Kenneth J; Gaarde, Mette B; Ghimire, Shambhu

2017-05-01

Solid-state high-harmonic sources offer the possibility of compact, high-repetition-rate attosecond light emitters. However, the time structure of high harmonics must be characterized at the sub-cycle level. We use strong two-cycle laser pulses to directly control the time-dependent nonlinear current in single-crystal MgO, leading to the generation of extreme ultraviolet harmonics. We find that harmonics are delayed with respect to each other, yielding an atto-chirp, the value of which depends on the laser field strength. Our results provide the foundation for attosecond pulse metrology based on solid-state harmonics and a new approach to studying sub-cycle dynamics in solids.

Impacts of abrupt climate changes in the Levant from Last Glacial Dead Sea levels

NASA Astrophysics Data System (ADS)

Torfstein, Adi; Goldstein, Steven L.; Stein, Mordechai; Enzel, Yehouda

2013-06-01

A new, detailed lake level curve for Lake Lisan (the Last Glacial Dead Sea) reveals a high frequency of abrupt fluctuations during Marine Isotope Stage 3 (MIS3) compared to the relatively high stand characterizing MIS2, and the significantly lower Holocene lake. The lake level fluctuations reflect the hydrological conditions in the large watershed of the lake, which in turn reflects the hydro-climatic conditions in the central Levant region. The new curve shows that the fluctuations coincide on millennial timescales with temperature variations recorded in Greenland. Four patterns of correlation are observed through the last ice age: (1) maximum lake elevations were reached during MIS2, the coldest interval; (2) abrupt lake level drops to the lowest elevations coincided with the occurrence of Heinrich (H) events; (3) the lake returned to higher-stand conditions along with warming in Greenland that followed H-events; (4) significant lake level fluctuations coincided with virtually every Greenland stadial-interstadial cycle. Over glacial-interglacial time-scales, Northern Hemisphere glacial cooling induces extreme wetness in the Levant, with high lake levels reaching ˜160 m below mean sea level (mbmsl), approximately 240 m above typical Holocene levels of ˜400 mbmsl. These orbital time-scale shifts are driven by expansions of the European ice sheet, which deflect westerly storm tracks southward to the Eastern Mediterranean, resulting in increased sea-air temperature gradients that invoke increased cyclogenesis, and enhanced moisture delivery to the Levant. The millennial-scale lake level drops associated with Greenland stadials are most extreme during Heinrich stadials and reflect abrupt cooling of the Eastern Mediterranean atmosphere and sea-surface, which weaken the cyclogenic rain engine and cause extreme Levant droughts. During the recovery from the effect of Heinrich stadials, the regional climate configuration resumed typical glacial conditions, with enhanced Levant precipitation and a rise in Lake Lisan levels. Similar cyclicity in the transfer of moisture to the Levant affected lake levels during all of the non-Heinrich stadial-interstadial cycles.

Are recent severe floods in Xiang River basin of China linked with the increase extreme precipitation?

NASA Astrophysics Data System (ADS)

Cheng, L.; Du, J.

2015-12-01

The Xiang River, a main tributary of the Yangtze River, is subjected to high floods frequently in recent twenty years. Climate change, including abrupt shifts and fluctuations in precipitation is an important factor influencing hydrological extreme conditions. In addition, human activities are widely recognized as another reasons leading to high flood risk. With the effects of climate change and human interventions on hydrological cycle, there are several questions that need to be addressed. Are floods in the Xiang River basin getting worse? Whether the extreme streamflow shows an increasing tendency? If so, is it because the extreme rainfall events have predominant effect on floods? To answer these questions, the article detected existing trends in extreme precipitation and discharge using Mann-Kendall test. Continuous wavelet transform method was employed to identify the consistency of changes in extreme precipitation and discharge. The Pearson correlation analysis was applied to investigate how much degree of variations in extreme discharge can be explained by climate change. The results indicate that slightly upward trends can be detected in both extreme rainfalls and discharge in the upper region of Xiang River basin. For the most area of middle and lower river basin, the extreme rainfalls show significant positive trends, but the extreme discharge displays slightly upward trends with no significance at 90% confidence level. Wavelet transform analysis results illustrate that highly similar patterns of signal changes can be seen between extreme precipitation and discharge in upper section of the basin, while the changes in extreme precipitation for the middle and lower reaches do not always coincide with the extreme streamflow. The correlation coefficients of the wavelet transforms for the precipitation and discharge signals in most area of the basin pass the significance test. The conclusion may be drawn that floods in recent years are not getting worse in Xiang River basin. The similar signal patterns and positive correlation between extreme discharge and precipitation indicate that the variability of extreme precipitation has an important effect on extreme discharge of flood, although the intensity of human impacts in lower section of Xiang River basin has increased markedly.

Extreme sea levels on the rise along Europe's coasts

NASA Astrophysics Data System (ADS)

Vousdoukas, Michalis I.; Mentaschi, Lorenzo; Voukouvalas, Evangelos; Verlaan, Martin; Feyen, Luc

2017-03-01

Future extreme sea levels (ESLs) and flood risk along European coasts will be strongly impacted by global warming. Yet, comprehensive projections of ESL that include mean sea level (MSL), tides, waves, and storm surges do not exist. Here, we show changes in all components of ESLs until 2100 in view of climate change. We find that by the end of this century, the 100-year ESL along Europe's coastlines is on average projected to increase by 57 cm for Representative Concentration Pathways (RCP)4.5 and 81 cm for RCP8.5. The North Sea region is projected to face the highest increase in ESLs, amounting to nearly 1 m under RCP8.5 by 2100, followed by the Baltic Sea and Atlantic coasts of the UK and Ireland. Relative sea level rise (RSLR) is shown to be the main driver of the projected rise in ESL, with increasing dominance toward the end of the century and for the high-concentration pathway. Changes in storm surges and waves enhance the effects of RSLR along the majority of northern European coasts, locally with contributions up to 40%. In southern Europe, episodic extreme events tend to stay stable, except along the Portuguese coast and the Gulf of Cadiz where reductions in surge and wave extremes offset RSLR by 20-30%. By the end of this century, 5 million Europeans currently under threat of a 100-year ESL could be annually at risk from coastal flooding under high-end warming. The presented dataset is available through this link: http://data.jrc.ec.europa.eu/collection/LISCOAST.

Advanced Power Sources for Space Missions

DTIC Science & Technology

1989-01-01

Range indicate that extremely high power levels hav- ing fast time-ramping capabilities must be provided during the tests. Only highly efficient prime...system efficiency results from advantages in thermal storage versus battery storage and from the increased conversion efficiency of a solar-dynamic... thermal manage- ment, power flow, and voltage levels, and may be in the same power range already experienced in the very- high -power radar and fusion

van Hove Singularities and Spectral Smearing in High Temperature Superconducting H3S

NASA Astrophysics Data System (ADS)

Quan, Yundi; Pickett, Warren E.

The superconducting phase of hydrogen sulfide at Tc=200 K observed by Drozdov and collaborators at pressures around 200 GPa is simple bcc Im 3 m H3S reopens questions about what is achievable in high Tc. The various ''extremes'' that are involved - pressure, implying extreme reduction of volume, extremely high H phonon energy scale around 1400K, extremely high temperature for a superconductor - necessitate a close look at new issues raised by these characteristics in relation to high Tc. We have applied first principles methods to analyze the H3S electronic structure, particularly the van Hove singularities (vHs) and the effect of sulfur. Focusing on the two closely spaced vHs near the Fermi level that give rise to the impressively sharp peak in the density of states, the implications of strong coupling Migdal-Eliashberg theory are assessed. The electron spectral density smearing due to virtual phonon emission and absorption, as done in earlier days for A15 superconductors, must be included explicitly to obtain accurate theoretical predictions and a correct understanding. Means for increasing Tc in H3S-like materials will be mentioned. NSF DMR Grant 1207622.

Space-time characteristics and statistical predictability of extreme daily precipitation events in the Ohio River Basin

NASA Astrophysics Data System (ADS)

Farnham, D. J.; Doss-Gollin, J.; Lall, U.

2016-12-01

In this study we identify the atmospheric conditions that precede and accompany regional extreme precipitation events with the potential to cause flooding. We begin by identifying a coherent space-time structure in the record of extreme precipitation within the Ohio River Basin through both a Hidden Markov Model and a composite analysis. The transition probabilities associated with the Hidden Markov Model illustrate a tendency for west to east migration of extreme precipitation events (> 99th percentile) at individual stations within the Ohio River Basin. We compute a record of regional extreme precipitation days by requiring that > p% of the basin's stations simultaneously experience extreme precipitation days. A composite analysis of low-level geopotential heights and column integrated precipitable water content for all non-summer seasons confirms a west to east migration and intensification of 1) a low (high) pressure center to the west (east) of the basin, and 2) enhanced precipitable water vapor content that stretches from the Gulf of Mexico to the Northeast US region in the days leading up to regional extreme precipitation days. We define a daily dipole index to summarize the strength of the paired cylonic and aniticyclonic systems to the west and east of the basin and analyze its temporal characteristics and its relationship to the regional extreme precipitation events. Lastly, we investigate and discuss the subseasonal predictability of individual extreme precipitation events and the seasonal predictability of active and inactive seasons, where the activity level is defined by the expected frequency of regional extreme precipitation events.

Downdrift in a Tone Language with Four Tone Levels.

ERIC Educational Resources Information Center

Clements, G. N.

1991-01-01

Many tone languages exhibit some form of downdrift or automatic downstep, the lowering of high tones separated by low tones. In extreme cases, the realization of high tones at the end of a domain (such as the sentence) may be lower than the realization of low tones at the beginning. Tone languages with this property are cross-level tone languages.…

Physical Activity Level and Sport Participation in Relation to Musculoskeletal Pain in a Population-Based Study of Adolescents

PubMed Central

Guddal, Maren Hjelle; Stensland, Synne Øien; Småstuen, Milada Cvancarova; Johnsen, Marianne Bakke; Zwart, John-Anker; Storheim, Kjersti

2017-01-01

Background: Prevalence of musculoskeletal pain among adolescents is high, and pain in adolescence increases the risk of chronic pain in adulthood. Studies have shown conflicting evidence regarding associations between physical activity and musculoskeletal pain, and few have evaluated the potential impact of sport participation on musculoskeletal pain in adolescent population samples. Purpose: To examine the associations between physical activity level, sport participation, and musculoskeletal pain in the neck and shoulders, low back, and lower extremities in a population-based sample of adolescents. Study Design: Cross-sectional study; Level of evidence 4. Methods: Data from the Nord-Trøndelag Health Study (Young-HUNT3) were used. All 10,464 adolescents in the Nord-Trøndelag county of Norway were invited, of whom 74% participated. Participants were asked how often they had experienced pain, unrelated to any known disease or acute injury, in the neck and shoulders, low back, and lower extremities in the past 3 months. The associations between (1) physical activity level (low [reference], medium or high) or (2) sport participation (weekly compared with no/infrequent participation) and pain were evaluated using logistic regression analyses, stratified by sex, and adjusted for age, socioeconomic status, and psychological distress. Results: The analyses included 7596 adolescents (mean age, 15.8 years; SD, 1.7). Neck and shoulder pain was most prevalent (17%). A moderate level of physical activity was associated with reduced odds of neck and shoulder pain (OR = 0.79 [95% CI, 0.66-0.94]) and low back pain (OR = 0.75 [95% CI, 0.62-0.91]), whereas a high level of activity increased the odds of lower extremity pain (OR = 1.60 [95% CI, 1.29-1.99]). Participation in endurance sports was associated with lower odds of neck and shoulder pain (OR = 0.79 [95% CI, 0.68-0.92]) and low back pain (OR = 0.77 [95% CI, 0.65-0.92]), especially among girls. Participation in technical sports was associated with increased odds of low back pain, whereas team sports were associated with increased odds of lower extremity pain. Strength and extreme sports were related to pain in all regions. Conclusion: We found that a moderate physical activity level was associated with less neck and shoulder pain and low back pain, and that participation in endurance sports may be particularly beneficial. Our findings highlight the need for health care professionals to consider the types of sports adolescents participate in when evaluating their musculoskeletal pain. PMID:28203603

Return levels of temperature extremes in southern Pakistan

NASA Astrophysics Data System (ADS)

Zahid, Maida; Blender, Richard; Lucarini, Valerio; Caterina Bramati, Maria

2017-12-01

Southern Pakistan (Sindh) is one of the hottest regions in the world and is highly vulnerable to temperature extremes. In order to improve rural and urban planning, it is useful to gather information about the recurrence of temperature extremes. In this work, return levels of the daily maximum temperature Tmax are estimated, as well as the daily maximum wet-bulb temperature TWmax extremes. We adopt the peaks over threshold (POT) method, which has not yet been used for similar studies in this region. Two main datasets are analyzed: temperatures observed at nine meteorological stations in southern Pakistan from 1980 to 2013, and the ERA-Interim (ECMWF reanalysis) data for the nearest corresponding locations. The analysis provides the 2-, 5-, 10-, 25-, 50-, and 100-year return levels (RLs) of temperature extremes. The 90 % quantile is found to be a suitable threshold for all stations. We find that the RLs of the observed Tmax are above 50 °C at northern stations and above 45 °C at the southern stations. The RLs of the observed TWmax exceed 35 °C in the region, which is considered as a limit of survivability. The RLs estimated from the ERA-Interim data are lower by 3 to 5 °C than the RLs assessed for the nine meteorological stations. A simple bias correction applied to ERA-Interim data improves the RLs remarkably, yet discrepancies are still present. The results have potential implications for the risk assessment of extreme temperatures in Sindh.

Global changes of extreme coastal wave energy fluxes triggered by intensified teleconnection patterns

NASA Astrophysics Data System (ADS)

Mentaschi, Lorenzo; Vousdoukas, Michalis I.; Voukouvalas, Evangelos; Dosio, Alessandro; Feyen, Luc

2017-03-01

In this study we conducted a comprehensive modeling analysis to identify global trends in extreme wave energy flux (WEF) along coastlines in the 21st century under a high emission pathway (Representative Concentration Pathways 8.5). For the end of the century, results show a significant increase up to 30% in 100 year return level WEF for the majority of the coastal areas of the southern temperate zone, while in the Northern Hemisphere large coastal areas are characterized by a significant negative trend. We show that the most significant long-term trends of extreme WEF can be explained by intensification of teleconnection patterns such as the Antarctic Oscillation, El Niño-Southern Oscillation, and North Atlantic Oscillation. The projected changes will have broad implications for ocean engineering applications and disaster risk management. Especially low-lying coastal countries in the Southern Hemisphere will be particularly vulnerable due to the combined effects of projected relative sea level rise and more extreme wave activities.

Approach bias and cue reactivity towards food in people with high versus low levels of food craving.

PubMed

Brockmeyer, Timo; Hahn, Carolyn; Reetz, Christina; Schmidt, Ulrike; Friederich, Hans-Christoph

2015-12-01

Even though people suffering from high levels of food craving are aware of the negative consequences of binge eating, they cannot resist. Automatic action tendencies (i.e. approach bias) towards food cues that operate outside conscious control may contribute to this dysfunctional behavior. The present study aimed to examine whether people with high levels of food craving show a stronger approach bias for food than those with low levels of food craving and whether this bias is associated with cue-elicited food craving. Forty-one individuals reporting either extremely high or extremely low levels of trait food craving were recruited via an online screening and compared regarding approach bias towards visual food cues by means of an implicit stimulus-response paradigm (i.e. the Food Approach-Avoidance Task). State levels of food craving were assessed before and after cue exposure to indicate food cue reactivity. As expected, high food cravers showed stronger automatic approach tendencies towards food than low food cravers. Also in line with the hypotheses, approach bias for food was positively correlated with the magnitude of change in state levels of food craving from pre-to post-cue exposure in the total sample. The findings suggest that an approach bias in early stages of information processing contributes to the inability to resist food intake and may be of relevance for understanding and treating dysfunctional eating behavior. Copyright © 2015 Elsevier Ltd. All rights reserved.

Characterization of extreme sea level at the European coast

NASA Astrophysics Data System (ADS)

Elizalde, Alberto; Jorda, Gabriel; Mathis, Moritz; Mikolajewicz, Uwe

2015-04-01

Extreme high sea levels arise as a combination of storm surges and particular high tides events. Future climate simulations not only project changes in the atmospheric circulation, which induces changes in the wind conditions, but also an increase in the global mean sea level by thermal expansion and ice melting. Such changes increase the risk of coastal flooding, which represents a possible hazard for human activities. Therefore, it is important to investigate the pattern of sea level variability and long-term trends at coastal areas. In order to analyze further extreme sea level events at the European coast in the future climate projections, a new setup for the global ocean model MPIOM coupled with the regional atmosphere model REMO is prepared. The MPIOM irregular grid has enhanced resolution in the European region to resolve the North and the Mediterranean Seas (up to 11 x 11 km at the North Sea). The ocean model includes as well the full luni-solar ephemeridic tidal potential for tides simulation. To simulate the air-sea interaction, the regional atmospheric model REMO is interactively coupled to the ocean model over Europe. Such region corresponds to the EuroCORDEX domain with a 50 x 50 km resolution. Besides the standard fluxes of heat, mass (freshwater), momentum and turbulent energy input, the ocean model is also forced with sea level pressure, in order to be able to capture the full variation of sea level. The hydrological budget within the study domain is closed using a hydrological discharge model. With this model, simulations for present climate and future climate scenarios are carried out to study transient changes on the sea level and extreme events. As a first step, two simulations (coupled and uncoupled ocean) driven by reanalysis data (ERA40) have been conducted. They are used as reference runs to evaluate the climate projection simulations. For selected locations at the coast side, time series of sea level are separated on its different components: tides, short time atmospheric process influence (1-30 days), seasonal cycle and interannual variability. Every sea level component is statistically compared with data from local tide gauges.

A comprehensive musculoskeletal and peripheral nervous system assessment of war-related bilateral upper extremity amputees.

PubMed

Allami, Mostafa; Mousavi, Batool; Masoumi, Mehdi; Modirian, Ehsan; Shojaei, Hadi; Mirsalimi, Fatemeh; Hosseini, Maryam; Pirouzi, Pirouz

2016-01-01

Upper limb amputations are one of the unpleasant war injuries that armed forces are exposed to frequently. The present study aimed to assess the musculoskeletal and peripheral nervous systems in Iraq-Iran war veterans with bilateral upper extremity amputation. The study consisted of taking a history and clinical examinations including demographic data, presence and location of pain, level of amputation, passive and active ranges of movement of the joints across the upper and lower extremities and spine, manual palpation, neurological examination, blood circulation pulses and issues related to a prosthetic limb. In this study, 103 Iranian bilateral upper extremity amputees (206 amputations) from the Iran-Iraq war were evaluated, and a detailed questionnaire was also administered. The most common level of amputation was the finger or wrist level (108, 52.4 %). Based on clinical examination, we found high frequencies of limited active and passive joint range of movement across the scapula, shoulder, elbow, wrist and metacarpophalangeal, interphalangeal and thumb joints. Based on muscle strength testing, we found varying degrees of weakness across the upper limbs. Musculoskeletal disorders included epicondylitis (65, 31.6 %), rotator cuff injury (24, 11.7 %), bicipital tendonitis (69, 33.5 %), shoulder drop (42, 20.4 %) and muscle atrophy (19, 9.2 %). Peripheral nerve disorders included carpal tunnel syndrome in 13 (6.3 %) and unilateral brachial plexus injury in 1 (1 %). Fifty-three (51.5 %) were diagnosed with facet joint syndrome at the level of the cervical spine (the most frequent site). Using a prosthesis was reported by 65 (63.1 %), both left and right sides. The back was the most common site of pain (71.8 %). The high prevalence of neuro-musculoskeletal disorders among bilateral upper extremity amputees indicates that they need regular rehabilitation care.

Research in Stochastic Processes.

DTIC Science & Technology

1982-12-01

constant high level boundary. References 1. Jurg Husler , Extremie values of non-stationary sequ-ences ard the extr-rmal index, Center for Stochastic...A. Weron, Oct. 82. 20. "Extreme values of non-stationary sequences and the extremal index." Jurg Husler , Oct. 82. 21. "A finitely additive white noise...string model, Y. Miyahara, Carleton University and Nagoya University. Sept. 22 On extremfe values of non-stationary sequences, J. Husler , University of

Using Free Internet Videogames in Upper Extremity Motor Training for Children with Cerebral Palsy.

PubMed

Sevick, Marisa; Eklund, Elizabeth; Mensch, Allison; Foreman, Matthew; Standeven, John; Engsberg, Jack

2016-06-07

Movement therapy is one type of upper extremity intervention for children with cerebral palsy (CP) to improve function. It requires high-intensity, repetitive and task-specific training. Tedium and lack of motivation are substantial barriers to completing the training. An approach to overcome these barriers is to couple the movement therapy with videogames. This investigation: (1) tested the feasibility of delivering a free Internet videogame upper extremity motor intervention to four children with CP (aged 8-17 years) with mild to moderate limitations to upper limb function; and (2) determined the level of intrinsic motivation during the intervention. The intervention used free Internet videogames in conjunction with the Microsoft Kinect motion sensor and the Flexible Action and Articulated Skeleton Toolkit software (FAAST) software. Results indicated that the intervention could be successfully delivered in the laboratory and the home, and pre- and post- impairment, function and performance assessments were possible. Results also indicated a high level of motivation among the participants. It was concluded that the use of inexpensive hardware and software in conjunction with free Internet videogames has the potential to be very motivating in helping to improve the upper extremity abilities of children with CP. Future work should include results from additional participants and from a control group in a randomized controlled trial to establish efficacy.

The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli

NASA Technical Reports Server (NTRS)

Rubin, C.; Xu, G.; Judex, S.

2001-01-01

It is generally believed that mechanical signals must be large in order to be anabolic to bone tissue. Recent evidence indicates, however, that extremely low-magnitude (<10 microstrain) mechanical signals readily stimulate bone formation if induced at a high frequency. We examined the ability of extremely low-magnitude, high-frequency mechanical signals to restore anabolic bone cell activity inhibited by disuse. Adult female rats were randomly assigned to six groups: baseline control, age-matched control, mechanically stimulated for 10 min/day, disuse (hind limb suspension), disuse interrupted by 10 min/day of weight bearing, and disuse interrupted by 10 min/day of mechanical stimulation. After a 28 day protocol, bone formation rates (BFR) in the proximal tibia of mechanically stimulated rats increased compared with age-matched control (+97%). Disuse alone reduced BFR (-92%), a suppression only slightly curbed when disuse was interrupted by 10 min of weight bearing (-61%). In contrast, disuse interrupted by 10 min per day of low-level mechanical intervention normalized BFR to values seen in age-matched controls. This work indicates that this noninvasive, extremely low-level stimulus may provide an effective biomechanical intervention for the bone loss that plagues long-term space flight, bed rest, or immobilization caused by paralysis.

Public Health Monitoring of Privilege and Deprivation With the Index of Concentration at the Extremes

PubMed Central

Waterman, Pamela D.; Spasojevic, Jasmina; Li, Wenhui; Maduro, Gil; Van Wye, Gretchen

2016-01-01

Objectives. We evaluated use of the Index of Concentration at the Extremes (ICE) for public health monitoring. Methods. We used New York City data centered around 2010 to assess cross-sectional associations at the census tract and community district levels, for (1) diverse ICE measures plus the US poverty rate, with (2) infant mortality, premature mortality (before age 65 years), and diabetes mortality. Results. Point estimates for rate ratios were consistently greatest for the novel ICE that jointly measured extreme concentrations of income and race/ethnicity. For example, the census tract–level rate ratio for infant mortality comparing the bottom versus top quintile for an ICE contrasting low-income Black versus high-income White equaled 2.93 (95% confidence interval [CI] = 2.11, 4.09), but was 2.19 (95% CI = 1.59, 3.02) for low versus high income, 2.77 (95% CI = 2.02, 3.81) for Black versus White, and 1.56 (95% CI = 1.19, 2.04) for census tracts with greater than or equal to 30% versus less than 10% below poverty. Conclusions. The ICE may be a useful metric for public health monitoring, as it simultaneously captures extremes of privilege and deprivation and can jointly measure economic and racial/ethnic segregation. PMID:26691119

Fiberoptic sensors for rocket engine applications

NASA Technical Reports Server (NTRS)

Ballard, R. O.

1992-01-01

A research effort was completed to summarize and evaluate the current level of technology in fiberoptic sensors for possible applications in integrated control and health monitoring (ICHM) systems in liquid propellant engines. The environment within a rocket engine is particuarly severe with very high temperatures and pressures present combined with extremely rapid fluid and gas flows, and high-velocity and high-intensity acoustc waves. Application of fiberoptic technology to rocket engine health monitoring is a logical evolutionary step in ICHM development and presents a significant challenge. In this extremely harsh environment, the additional flexibility of fiberoptic techniques to augment conventional sensor technologies offer abundant future potential.

Therapeutic apheresis for severe hypertriglyceridemia in pregnancy.

PubMed

Basar, Rafet; Uzum, Ayse Kubat; Canbaz, Bulent; Dogansen, Sema Ciftci; Kalayoglu-Besisik, Sevgi; Altay-Dadin, Senem; Aral, Ferihan; Ozbey, Nese Colak

2013-05-01

During pregnancy, a progressive increase in serum triglyceride (TG) and cholesterol levels is observed whereas TG levels mostly remain <300 mg/dl. In women with genetic forms of hypertriglyceridemia, pregnancy may cause extremely elevated TG levels leading to potentially life-threatening pancreatitis attacks and chylomicronemia syndrome. The only safe medical treatment option during pregnancy is ω-3 fatty acids, which have moderate TG lowering effects. Therapeutic apheresis could be used as primary treatment approach during pregnancy. We reported the effect of double filtration apheresis in one pregnant women with severe hypertriglyceridemia, therapeutic plasmapheresis and double filtration methods in the other severe hypertriglyceridemic pregnant woman; a 32-year-old pregnant woman (patient 1) with a history of hypertriglyceridemia-induced acute pancreatitis during pregnancy and a 30-year-old pregnant woman with extremely high TG levels (12,000 mg/dl) leading to chylomicronemia syndrome (patient 2). Medical nutrition therapy and ω-3 fatty acids were also provided. Double filtration apheresis (patient 1) and plasmapheresis + double filtration apheresis (patient 2) were used. When we calculated the TG levels before and after therapeutic apheresis, maximum decrease achieved with double filtration apheresis was 46.3 % for patient 1 and 37.3 % for patient 2. However, with plasmapheresis TG level declined by 72 % in patient 2. Plasmapheresis seemed to be more efficient to decrease TG levels. Iron deficiency anemia was the main complication apart from technical difficulties by lipemic obstruction of tubing system. Healthy babies were born. Delivery led to decreases in TG levels. It is concluded that during pregnancy therapeutic apheresis is an effective method to decrease extremely high TG levels and risks of its potentially life-threatening complications.

Spatiotemporal variability of extreme temperature frequency and amplitude in China

NASA Astrophysics Data System (ADS)

Zhang, Yuanjie; Gao, Zhiqiu; Pan, Zaitao; Li, Dan; Huang, Xinhui

2017-03-01

Temperature extremes in China are examined based on daily maximum and minimum temperatures from station observations and multiple global climate models. The magnitude and frequency of extremes are expressed in terms of return values and periods, respectively, estimated by the fitted Generalized Extreme Value (GEV) distribution of annual extreme temperatures. The observations suggest that changes in temperature extremes considerably exceed changes in the respective climatological means during the past five decades, with greater amplitude of increases in cold extremes than in warm extremes. The frequency of warm (cold) extremes increases (decreases) over most areas, with an increasingly faster rate as the extremity level rises. Changes in warm extremes are more dependent on the varying shape of GEV distribution than the location shift, whereas changes in cold extremes are more closely associated with the location shift. The models simulate the overall pattern of temperature extremes during 1961-1981 reasonably well in China, but they show a smaller asymmetry between changes in warm and cold extremes primarily due to their underestimation of increases in cold extremes especially over southern China. Projections from a high emission scenario show the multi-model median change in warm and cold extremes by 2040 relative to 1971 will be 2.6 °C and 2.8 °C, respectively, with the strongest changes in cold extremes shifting southward. By 2040, warm extremes at the 1971 20-year return values would occur about every three years, while the 1971 cold extremes would occur once in > 500 years.

Extreme geomagnetically induced currents

NASA Astrophysics Data System (ADS)

Kataoka, Ryuho; Ngwira, Chigomezyo

2016-12-01

We propose an emergency alert framework for geomagnetically induced currents (GICs), based on the empirically extreme values and theoretical upper limits of the solar wind parameters and of d B/d t, the time derivative of magnetic field variations at ground. We expect this framework to be useful for preparing against extreme events. Our analysis is based on a review of various papers, including those presented during Extreme Space Weather Workshops held in Japan in 2011, 2012, 2013, and 2014. Large-amplitude d B/d t values are the major cause of hazards associated with three different types of GICs: (1) slow d B/d t with ring current evolution (RC-type), (2) fast d B/d t associated with auroral electrojet activity (AE-type), and (3) transient d B/d t of sudden commencements (SC-type). We set "caution," "warning," and "emergency" alert levels during the main phase of superstorms with the peak Dst index of less than -300 nT (once per 10 years), -600 nT (once per 60 years), or -900 nT (once per 100 years), respectively. The extreme d B/d t values of the AE-type GICs are 2000, 4000, and 6000 nT/min at caution, warning, and emergency levels, respectively. For the SC-type GICs, a "transient alert" is also proposed for d B/d t values of 40 nT/s at low latitudes and 110 nT/s at high latitudes, especially when the solar energetic particle flux is unusually high.

Sharpening ball-nose mill cutters

NASA Technical Reports Server (NTRS)

Burch, C. F.

1977-01-01

Economical attachment allows faster, more precise grinding. Vibrationless and rigid relation between grinding wheel and cutter allows for extremely high finish and accurate grinding. Leveling device levels flutes with respect to toolholder rotation that generates ball-nose radius. Constant relief around entire profile of cutting edge produces longer tool life.

Serological and virological profile of chronic HBV infected women at reproductive age in Greece. A two-year single center study.

PubMed

Elefsiniotis, Ioannis S; Glynou, Irene; Brokalaki, Hero; Magaziotou, Ioanna; Pantazis, Konstantinos D; Fotiou, Aikaterini; Liosis, George; Kada, Helen; Saroglou, George

2007-06-01

Seroprevalence of HBsAg in 26,746 women at reproductive age in Greece and evaluation of HBeAg/anti-HBe serological status as well as serum HBV-DNA levels in a subgroup of HBsAg(+) women at labor. Serological markers were detected using enzyme immunoassays. Serum HBV-DNA was calculated using a sensitive quantitative PCR assay, with a lower limit of quantification of 200 copies/ml. Overall, 1.53% of women were HBsAg(+) and the majority of them (64.96%) were Albanian. Among Albanian women the mean prevalence of HBsAg was 4.9%, 5.57% among Asian women, and 1.29% among women from Eastern European countries. The prevalence of HBsAg among African (0.29%) and Greek women (0.57%) was very low and significantly lower in comparison with the mean value of the studied population. Only 2.67% of HBsAg(+) women were HBeAg(+). Of a subgroup of women in labor with available serum samples 28.6% had undetectable levels of viremia (<200 copies/ml) and 15.9% had extremely low levels of viral replication (<400 copies/ml). Only 12.7% of pregnant women evaluated at labor exhibited extremely high serum HBV-DNA levels (>10,000,000 copies/ml) whereas 42.8% of them exhibited HBV-DNA levels between 1500 and 40,000 copies/ml. The overall prevalence of HBsAg is relatively low among women at reproductive age in Greece but is higher among specific ethnic populations (Asian, Albanian). The HBeAg(-)/antiHBe(+) serological status is a finding observed in the vast majority of HBsAg(+) women of our study population, and a significant percentage of them (approximately 44.5%) exhibit extremely low or even undetectable levels of viral replication at labor, suggesting possibly that only a proportion of HBsAg(+) women in Greece exhibit an extremely high risk of vertical transmission of the infection.

Climate projection of synoptic patterns forming extremely high wind speed over the Barents Sea

NASA Astrophysics Data System (ADS)

Surkova, Galina; Krylov, Aleksey

2017-04-01

Frequency of extreme weather events is not very high, but their consequences for the human well-being may be hazardous. These seldom events are not always well simulated by climate models directly. Sometimes it is more effective to analyze numerical projection of large-scale synoptic event generating extreme weather. For example, in mid-latitude surface wind speed depends mainly on the sea level pressure (SLP) field - its configuration and horizontal pressure gradient. This idea was implemented for analysis of extreme wind speed events over the Barents Sea. The calendar of high surface wind speed V (10 m above the surface) was prepared for events with V exceeding 99th percentile value in the central part of the Barents Sea. Analysis of probability distribution function of V was carried out on the base of ERA-Interim reanalysis data (6-hours, 0.75x0.75 degrees of latitude and longitude) for the period 1981-2010. Storm wind events number was found to be 240 days. Sea level pressure field over the sea and surrounding area was selected for each storm wind event. For the climate of the future (scenario RCP8.5), projections of SLP from CMIP5 numerical experiments were used. More than 20 climate models results of projected SLP (2006-2100) over the Barents Sea were correlated with modern storm wind SLP fields. Our calculations showed the positive tendency of annual frequency of storm SLP patterns over the Barents Sea by the end of 21st century.

Improving the Predictability of Severe Water Levels along the Coasts of Marginal Seas

NASA Astrophysics Data System (ADS)

Ridder, N. N.; de Vries, H.; van den Brink, H.; De Vries, H.

2016-12-01

Extreme water levels can lead to catastrophic consequences with severe societal and economic repercussions. Particularly vulnerable are countries that are largely situated below sea level. To support and optimize forecast models, as well as future adaptation efforts, this study assesses the modeled contribution of storm surges and astronomical tides to total water levels under different air-sea momentum transfer parameterizations in a numerical surge model (WAQUA/DCSMv5) of the North Sea. It particularly focuses on the implications for the representation of extreme and rapidly recurring severe water levels over the past decades based on the example of the Netherlands. For this, WAQUA/DCSMv5, which is currently used to forecast coastal water levels in the Netherlands, is forced with ERA Interim reanalysis data. Model results are obtained from two different methodologies to parameterize air-sea momentum transfer. The first calculates the governing wind stress forcing using a drag coefficient derived from the conventional approach of wind speed dependent Charnock constants. The other uses instantaneous wind stress from the parameterization of the quasi-linear theory applied within the ECMWF wave model which is expected to deliver a more realistic forcing. The performance of both methods is tested by validating the model output with observations, paying particular attention to their ability to reproduce rapidly succeeding high water levels and extreme events. In a second step, the common features of and connections between these events are analyzed. The results of this study will allow recommendations for the improvement of water level forecasts within marginal seas and support decisions by policy makers. Furthermore, they will strengthen the general understanding of severe and extreme water levels as a whole and help to extend the currently limited knowledge about clustering events.

An Evaluation of the Possible Association of Malignant Hyperpyrexia with the Noonan Syndrome Using Serum Creatine Phosphokinase Levels

ERIC Educational Resources Information Center

Hunter, Alasdair; Pinsky, Leonard

1975-01-01

Examined for malignant hyperpyrexia (extremely high fever) were serum creatine phosphokinase (enzyme) levels of 27 children from 1-to 17-years-old with Noonan syndrome which is characterized by webbed neck, short stature and low set ears. (CL)

Heat Vulnerability Index Mapping for Milwaukee and Wisconsin.

PubMed

Christenson, Megan; Geiger, Sarah Dee; Phillips, Jeffrey; Anderson, Ben; Losurdo, Giovanna; Anderson, Henry A

Extreme heat waves elevate the population's risk for heat-related morbidity and mortality, specifically for vulnerable groups such as older adults and young children. In this context, we developed 2 Heat Vulnerability Indices (HVIs), one for the state of Wisconsin and one for the Milwaukee metropolitan area. Through the creation of an HVI, state and local agencies will be able to use the indices as a planning tool for extreme heat events. Data used for the HVIs were grouped into 4 categories: (1) population density; (2) health factors; (3) demographic and socioeconomic factors; and (4) natural and built environment factors. These categories were mapped at the Census block group level. Unweighted z-score data were used to determine index scores, which were then mapped by quantiles ranging from "high" to "low" vulnerability. Statewide, Menominee County exhibited the highest vulnerability to extreme heat. Milwaukee HVI findings indicated high vulnerability in the city's inner core versus low vulnerability along the lakeshore. Visualization of vulnerability could help local public health agencies prepare for future extreme heat events.

Relativistic frequency upshift to the extreme ultraviolet regime using self-induced oscillatory flying mirrors

PubMed Central

Kim, I Jong; Pae, Ki Hong; Kim, Chul Min; Kim, Hyung Taek; Yun, Hyeok; Yun, Sang Jae; Sung, Jae Hee; Lee, Seong Ku; Yoon, Jin Woo; Yu, Tae Jun; Jeong, Tae Moon; Nam, Chang Hee; Lee, Jongmin

2012-01-01

Coherent short-wavelength radiation from laser–plasma interactions is of increasing interest in disciplines including ultrafast biomolecular imaging and attosecond physics. Using solid targets instead of atomic gases could enable the generation of coherent extreme ultraviolet radiation with higher energy and more energetic photons. Here we present the generation of extreme ultraviolet radiation through coherent high-harmonic generation from self-induced oscillatory flying mirrors—a new-generation mechanism established in a long underdense plasma on a solid target. Using a 30-fs, 100-TW Ti:sapphire laser, we obtain wavelengths as short as 4.9 nm for an optimized level of amplified spontaneous emission. Particle-in-cell simulations show that oscillatory flying electron nanosheets form in a long underdense plasma, and suggest that the high-harmonic generation is caused by reflection of the laser pulse from electron nanosheets. We expect this extreme ultraviolet radiation to be valuable in realizing a compact X-ray instrument for research in biomolecular imaging and attosecond physics. PMID:23187631

An Agent-Based Modeling Approach to Integrate Tsunami Science, Human Behavior, and Unplanned Network Disruptions for Nearfield Tsunami Evacuation

NASA Astrophysics Data System (ADS)

Cox, D. T.; Wang, H.; Cramer, L.; Mostafizi, A.; Park, H.

2016-12-01

A 2015 heatwave in Pakistan is blamed for over a thousand deaths. This event consisted of several days of very high temperatures and unusually high humidity for this region. However, none of these days exceeded the threshold for "extreme danger" in terms of the heat index. The heat index is a univariate function of both temperature and humidity which is universally applied at all locations regardless of local climate. Understanding extremes which arise from multiple factors is challenging. In this paper we will present a tool for examining bivariate extreme behavior. The tool, developed in the statistical software R, draws isolines of equal exceedance probability. These isolines can be understood as bivariate "return levels". The tool is based on a dependence framework specific for extremes, is semiparametric, and is able to extrapolate isolines beyond the range of the data. We illustrate this tool using the Pakistan heat wave data and other bivariate data.

Solar Power Generation in Extreme Space Environments

NASA Technical Reports Server (NTRS)

Elliott, Frederick W.; Piszczor, Michael F.

2016-01-01

The exploration of space requires power for guidance, navigation, and control; instrumentation; thermal control; communications and data handling; and many subsystems and activities. Generating sufficient and reliable power in deep space through the use of solar arrays becomes even more challenging as solar intensity decreases and high radiation levels begin to degrade the performance of photovoltaic devices. The Extreme Environments Solar Power (EESP) project goal is to develop advanced photovoltaic technology to address these challenges.

The High-Energy Astrophysics Learning Center, Version 1. [CD-ROM].

ERIC Educational Resources Information Center

Whitlock, Laura A.; Allen, Jesse S.; Lochner, James C.

The High-Energy Astrophysics (HEA) Learning Center gives students, teachers, and the general public a window into the world of high-energy astrophysics. The universe is revealed through x-rays and gamma rays where matter exists under extreme conditions. Information is available on astrophysics at a variety of reading levels, and is illustrated…

Calibration and validation of CSM-CROPGRO-cotton model using lysimeter data in the Texas High Plains

USDA-ARS?s Scientific Manuscript database

The Texas High Plains (THP) is one of the most important food and fiber producing regions in the Ogallala Aquifer Region, currently facing rapid decline of groundwater levels. Predicated climate extremes and high temporal variability in growing season precipitation in the future may demand growers t...

Tree Mortality

Treesearch

Mark J. Ambrose

2012-01-01

Tree mortality is a natural process in all forest ecosystems. However, extremely high mortality also can be an indicator of forest health issues. On a regional scale, high mortality levels may indicate widespread insect or disease problems. High mortality may also occur if a large proportion of the forest in a particular region is made up of older, senescent stands....

Changes in insecticide resistance of the rice striped stem borer (Lepidoptera: Crambidae).

PubMed

Su, Jianya; Zhang, Zhenzhen; Wu, Min; Gao, Congfen

2014-02-01

Application of insecticides is the most important method to control Chilo suppressalis (Walker) (Lepidoptera: Crambidae), and continuous use of individual insecticides has driven the rapid development of insecticide resistance in C. suppressalis during the past 30 yr. Monitoring insecticide resistance provides information essential for integrated pest management. Insecticide resistance of field populations to monosultap, triazophos, chlorpyrifos, and abamectin in China was examined in 2010 and 2011. The results indicated that the resistance levels of 14 field populations to four insecticides were significantly different. Four populations showed moderate resistance, and other populations possessed low-level resistance or were susceptible to monosultap. Nine populations displayed an extremely high or a high level of resistance to triazophos, whereas four populations were sensitive to this agent. Five populations exhibited a low level of resistance to abamectin, while the others remained sensitive. When compared with historical data, resistance to monosultap and triazophos decreased significantly, and the percentage of populations with high-level or extremely high-level resistance was obviously reduced. By contrast, the resistance to abamectin increased slightly. The increasing and decreasing resistance levels reported in this study highlight the different evolutionary patterns of insecticide resistance in C. suppressalis. An overreliance on one or two insecticides may promote rapid development of resistance. Slow development of resistance to abamectin, which was used mainly in mixtures with other insecticides, implies that the use of insecticide mixtures may be an effective method to delay the evolution of resistance to insecticides.

Climate extremes promote fatal co-infections during canine distemper epidemics in African lions.

PubMed

Munson, Linda; Terio, Karen A; Kock, Richard; Mlengeya, Titus; Roelke, Melody E; Dubovi, Edward; Summers, Brian; Sinclair, Anthony R E; Packer, Craig

2008-06-25

Extreme climatic conditions may alter historic host-pathogen relationships and synchronize the temporal and spatial convergence of multiple infectious agents, triggering epidemics with far greater mortality than those due to single pathogens. Here we present the first data to clearly illustrate how climate extremes can promote a complex interplay between epidemic and endemic pathogens that are normally tolerated in isolation, but with co-infection, result in catastrophic mortality. A 1994 canine distemper virus (CDV) epidemic in Serengeti lions (Panthera leo) coincided with the death of a third of the population, and a second high-mortality CDV epidemic struck the nearby Ngorongoro Crater lion population in 2001. The extent of adult mortalities was unusual for CDV and prompted an investigation into contributing factors. Serological analyses indicated that at least five "silent" CDV epidemics swept through the same two lion populations between 1976 and 2006 without clinical signs or measurable mortality, indicating that CDV was not necessarily fatal. Clinical and pathology findings suggested that hemoparsitism was a major contributing factor during fatal epidemics. Using quantitative real-time PCR, we measured the magnitude of hemoparasite infections in these populations over 22 years and demonstrated significantly higher levels of Babesia during the 1994 and 2001 epidemics. Babesia levels correlated with mortalities and extent of CDV exposure within prides. The common event preceding the two high mortality CDV outbreaks was extreme drought conditions with wide-spread herbivore die-offs, most notably of Cape buffalo (Syncerus caffer). As a consequence of high tick numbers after the resumption of rains and heavy tick infestations of starving buffalo, the lions were infected by unusually high numbers of Babesia, infections that were magnified by the immunosuppressive effects of coincident CDV, leading to unprecedented mortality. Such mass mortality events may become increasingly common if climate extremes disrupt historic stable relationships between co-existing pathogens and their susceptible hosts.

Climate Extremes Promote Fatal Co-Infections during Canine Distemper Epidemics in African Lions

PubMed Central

Munson, Linda; Terio, Karen A.; Kock, Richard; Mlengeya, Titus; Roelke, Melody E.; Dubovi, Edward; Summers, Brian; Sinclair, Anthony R. E.; Packer, Craig

2008-01-01

Extreme climatic conditions may alter historic host-pathogen relationships and synchronize the temporal and spatial convergence of multiple infectious agents, triggering epidemics with far greater mortality than those due to single pathogens. Here we present the first data to clearly illustrate how climate extremes can promote a complex interplay between epidemic and endemic pathogens that are normally tolerated in isolation, but with co-infection, result in catastrophic mortality. A 1994 canine distemper virus (CDV) epidemic in Serengeti lions (Panthera leo) coincided with the death of a third of the population, and a second high-mortality CDV epidemic struck the nearby Ngorongoro Crater lion population in 2001. The extent of adult mortalities was unusual for CDV and prompted an investigation into contributing factors. Serological analyses indicated that at least five “silent” CDV epidemics swept through the same two lion populations between 1976 and 2006 without clinical signs or measurable mortality, indicating that CDV was not necessarily fatal. Clinical and pathology findings suggested that hemoparsitism was a major contributing factor during fatal epidemics. Using quantitative real-time PCR, we measured the magnitude of hemoparasite infections in these populations over 22 years and demonstrated significantly higher levels of Babesia during the 1994 and 2001 epidemics. Babesia levels correlated with mortalities and extent of CDV exposure within prides. The common event preceding the two high mortality CDV outbreaks was extreme drought conditions with wide-spread herbivore die-offs, most notably of Cape buffalo (Syncerus caffer). As a consequence of high tick numbers after the resumption of rains and heavy tick infestations of starving buffalo, the lions were infected by unusually high numbers of Babesia, infections that were magnified by the immunosuppressive effects of coincident CDV, leading to unprecedented mortality. Such mass mortality events may become increasingly common if climate extremes disrupt historic stable relationships between co-existing pathogens and their susceptible hosts. PMID:18575601

A first order theory of the p/+/-n-n/+/ edge-illuminated silicon solar cell at very high injection levels

NASA Technical Reports Server (NTRS)

Goradia, C.; Sater, B. L.

1977-01-01

A first order theory of the edge-illuminated p(+)-n-n(+) silicon solar cell under very high injection levels has been derived. The very high injection level illuminated J-V characteristic is derived for any general base width to diffusion length (W/L) ratio and it includes the minority carrier reflection by the n-n(+) high-low junction. The beneficial effects of the high-low junction are shown to be significant until extremely high injection levels are reached. The theoretical dependencies of Jsc and Voc on temperature, incident intensity, and base resistivity are derived and discussed in detail. Some experimental results are given and these are discussed in relation to the theory.

North Atlantic Coast Comprehensive Study Phase I: Statistical Analysis of Historical Extreme Water Levels with Sea Level Change

DTIC Science & Technology

2014-09-01

14-7 ii Abstract The U.S. North Atlantic coast is subject to coastal flooding as a result of both severe extratropical storms (e.g., Nor’easters...Products and Services, excluding any kind of high-resolution hydrodynamic modeling. Tropical and extratropical storms were treated as a single...joint probability analysis and high-fidelity modeling of tropical and extratropical storms

[Severely increased serum lipid levels in diabetic ketoacidosis - case report].

PubMed

Stefansson, Hrafnkell; Sigvaldason, Kristinn; Kjartansson, Hilmar; Sigurjonsdottir, Helga Águsta

2017-01-01

Severe hypertriglyceridemia is a known, but uncommon complication of diabetic ketoacidosis. We discuss the case of a 23-year-old, previously healthy, woman who initially presented to the emergency department with abdominal pain. Grossly lipemic serum due to extremely high triglyceride (38.6 mmol/L) and cholesterol (23.2 mmol/L) levels were observed with a high blood glucose (23 mmol/L) and a low pH of 7.06 on a venous blood gas. She was treated successfully with fluids and insulin and had no sequale of pancreatitis or cerebral edema. Her triglycerides and cholesterol was normalized in three days and she was discharged home on insulin therapy after five days. Further history revealed a recent change in diet with no meat, fish or poultry consumption in the last 12 months and concomitantly an increase in carbohydrate intake which might have contributed to her extremely high serum lipid levels. This case demonstrates that clinicians should be mindful of the different presentations of diabetic ketoacidosis. Key words: diabetic ketoacidosis, hypertriglyceridemia, hyperlipidemia, vegan diet, carbohydrate diet. Correspondence: Hrafnkell Stefansson, hrafnkell.stefans@gmail.com.

Coastal-storm Inundation and Sea-level Rise in New Zealand Scott A. Stephens and Rob Bell

NASA Astrophysics Data System (ADS)

Stephens, S. A.; Bell, R.

2016-12-01

Coastal-storm inundation is a growing problem in New Zealand. It happens occasionally, when the combined forces of weather and sea line up, causing inundation of low-elevation land, coastal erosion, and rivers and stormwater systems to back up causing inland flooding. This becomes a risk where we have placed buildings and infrastructure too close to the coast. Coastal-storm inundation is not a new problem, it has happened historically, but it is becoming more frequent as the sea level continues to rise. From analyses of historic extreme sea-level events, we show how the different sea-level components, such as tide and storm surge, contribute to extreme sea-level and how these components vary around New Zealand. Recent sea-level analyses reveal some large storm surges, bigger than previously reported, and we show the type of weather patterns that drive them, and how this leads to differences in storm surge potential between the east and west coasts. Although large and damaging storm-tides have occurred historically, we show that there is potential for considerably larger elevations to be reached in the "perfect storm", and we estimate the likelihood of such extreme events occurring. Sea-level rise (SLR) will greatly increase the frequency, depth and consequences of coastal-storm inundation in the future. We show an application of a new method to determine the increasing frequency of extreme sea-levels with SLR, one which integrates the extreme tail with regularly-occurring high tides. We present spatial maps of several extreme sea-level threshold exceedance statistics for a case study at Mission Bay, Auckland, New Zealand. The maps show how the local community is likely to face decision points at various SLR thresholds, and we conclude that coastal hazard assessments should ideally use several SLR scenarios and time windows within the next 100 years or more to support the decision-making process for future coastal adaptation and when response options will be needed. In tandem, coastal hazard assessments should also provide information on SLR values linked to expected inundation frequency or depth. This can be linked to plausible timeframes for SLR thresholds to determine when critical decision points for adaptation might be reached, and we show how this might be achieved.

Castable thermal insulation for use as heat shields

NASA Technical Reports Server (NTRS)

Mountvala, A. J.; Nakamura, H. H.; Rechter, H. L.

1974-01-01

Structural members supporting the afterburners of high thrust rocket engines are subjected to extreme heating, along with severe vibration and high acceleration levels during early lift-off. Chemically-bonded, castable, zircon composite foams were developed and successfully tested to meet specific, laboratory simulated lift-off conditions.

Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review.

PubMed

Burtscher, Martin; Gatterer, Hannes; Burtscher, Johannes; Mairbäurl, Heimo

2018-01-01

Living, working and exercising in extreme terrestrial environments are challenging tasks even for healthy humans of the modern new age. The issue is not just survival in remote environments but rather the achievement of optimal performance in everyday life, occupation, and sports. Various adaptive biological processes can take place to cope with the specific stressors of extreme terrestrial environments like cold, heat, and hypoxia (high altitude). This review provides an overview of the physiological and morphological aspects of adaptive responses in these environmental stressors at the level of organs, tissues, and cells. Furthermore, adjustments existing in native people living in such extreme conditions on the earth as well as acute adaptive responses in newcomers are discussed. These insights into general adaptability of humans are complemented by outcomes of specific acclimatization/acclimation studies adding important information how to cope appropriately with extreme environmental temperatures and hypoxia.

Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review

PubMed Central

Burtscher, Martin; Gatterer, Hannes; Burtscher, Johannes; Mairbäurl, Heimo

2018-01-01

Living, working and exercising in extreme terrestrial environments are challenging tasks even for healthy humans of the modern new age. The issue is not just survival in remote environments but rather the achievement of optimal performance in everyday life, occupation, and sports. Various adaptive biological processes can take place to cope with the specific stressors of extreme terrestrial environments like cold, heat, and hypoxia (high altitude). This review provides an overview of the physiological and morphological aspects of adaptive responses in these environmental stressors at the level of organs, tissues, and cells. Furthermore, adjustments existing in native people living in such extreme conditions on the earth as well as acute adaptive responses in newcomers are discussed. These insights into general adaptability of humans are complemented by outcomes of specific acclimatization/acclimation studies adding important information how to cope appropriately with extreme environmental temperatures and hypoxia. PMID:29867589

Public Perception of Extreme Cold Weather-Related Health Risk in a Cold Area of Northeast China.

PubMed

Ban, Jie; Lan, Li; Yang, Chao; Wang, Jian; Chen, Chen; Huang, Ganlin; Li, Tiantian

2017-08-01

A need exists for public health strategies regarding extreme weather disasters, which in recent years have become more frequent. This study aimed to understand the public's perception of extreme cold and its related health risks, which may provide detailed information for public health preparedness during an extreme cold weather event. To evaluate public perceptions of cold-related health risk and to identify vulnerable groups, we collected responses from 891 participants in a face-to-face survey in Harbin, China. Public perception was measured by calculating the score for each perception question. Locals perceived that extreme cold weather and related health risks were serious, but thought they could not avoid these risks. The significant difference in perceived acceptance level between age groups suggested that the elderly are a "high health risk, low risk perception" group, meaning that they are relatively more vulnerable owing to their high susceptibility and low awareness of the health risks associated with extreme cold weather. The elderly should be a priority in risk communication and health protective interventions. This study demonstrated that introducing risk perception into the public health field can identify vulnerable groups with greater needs, which may improve the decision-making of public health intervention strategies. (Disaster Med Public Health Preparedness. 2017;11:417-421).

Extremely Preterm Infant Skin Care: A Transformation of Practice Aimed to Prevent Harm.

PubMed

Johnson, Deanna E

2016-10-01

The skin of extremely preterm infants is underdeveloped and has poor barrier function. Skin maintenance interventions initiated in the neonatal intensive care unit (NICU) have immediate and lifelong implications when the potential for infection, allergen sensitization, and altered aesthetic outcomes are considered. In addition, the high-level medical needs of extremely preterm infants demand skin-level medical interventions that too often result in unintended skin harm. We describe the use of a harm prevention, or consequence-centered, approach to skin care, which facilitates safer practice for extremely premature infants. Neonatal and pediatric Advanced Practice Registered Nurses (APRN) came together for monthly meetings to review the evidence around best skin care practices for extremely preterm infants, with an emphasis on reduction of skin harm. Findings were focused on the population of interest and clinical implementation strategies. Skin care for extremely preterm infants remains overlooked by current literature. However, clinical practice pearls were extracted and applied in a manner that promotes safer skin care practices in the NICU. Gentle adhesives, such as silicone tapes and hydrogel-backed electrodes, can help to reduce medical adhesive-related skin injuries. Diaper wipes are not appropriate for use among extremely preterm infants, as many ingredients may contain potential allergens. Skin cleansers should be pH neutral to the skin and the prophylactic use of petrolatum-based emollients should be avoided. Further exploration and understanding of skin care practices that examine issues of true risk versus hypothetical risk of harm.

Visuo-spatial processing in autism--testing the predictions of extreme male brain theory.

PubMed

Falter, Christine M; Plaisted, Kate C; Davis, Greg

2008-03-01

It has been hypothesised that autism is an extreme version of the male brain, caused by high levels of prenatal testosterone (Baron-Cohen 1999). To test this proposal, associations were assessed between three visuo-spatial tasks and prenatal testosterone, indexed in second-to-fourth digit length ratios (2D:4D). The study included children with Autism Spectrum Disorder, ASD (N = 28), and chronological as well as mental age matched typically-developing children (N = 31). While the group with ASD outperformed the control group at Mental Rotation and Figure-Disembedding, these group differences were not related to differences in prenatal testosterone level. Previous findings of an association between Targeting and 2D:4D were replicated in typically-developing children and children with ASD. The implications of these results for the extreme male brain (EMB) theory of autism are discussed.

Variations in extreme precipitation on the Loess Plateau using a high-resolution dataset and their linkages with atmospheric circulation indices

NASA Astrophysics Data System (ADS)

Zhao, Guangju; Zhai, Jianqing; Tian, Peng; Zhang, Limei; Mu, Xingmin; An, Zhengfeng; Han, Mengwei

2017-08-01

Assessing regional patterns and trends in extreme precipitation is crucial for facilitating flood control and drought adaptation because extreme climate events have more damaging impacts on society and ecosystems than simple shifts in the mean values. In this study, we employed daily precipitation data from 231 climate stations spanning 1961 to 2014 to explore the changes in precipitation extremes on the Loess Plateau, China. Nine of the 12 extreme precipitation indices suggested decreasing trends, and only the annual total wet-day precipitation (PRCPTOT) and R10 declined significantly: - 0.69 mm/a and - 0.023 days/a at the 95% confidence level. The spatial patterns in all of the extreme precipitation indices indicated mixed trends on the Loess Plateau, with decreasing trends in the precipitation extremes at the majority of the stations examined in the Fen-Wei River valley and high-plain plateau. Most of extreme precipitation indices suggested apparent regional differences, whereas R25 and R20 had spatially similar patterns on the Loess Plateau, with many stations revealing no trends. In addition, we found a potential decreasing trend in rainfall amounts and rainy days and increasing trends in rainfall intensities and storm frequencies in some regions due to increasing precipitation events in recent years. The relationships between extreme rainfall events and atmospheric circulation indices suggest that the weakening trend in the East Asia summer monsoon has limited the northward extension of the rainfall belt to northern China, thereby leading to a decrease in rainfall on the Loess Plateau.

Responses of CO2 Fluxes to Arctic Browning Events in a Range of High Latitude, Shrub-Dominated Ecosystems

NASA Astrophysics Data System (ADS)

Phoenix, G. K.; Treharne, R.; Emberson, L.; Tømmervik, H. A.; Bjerke, J. W.

2017-12-01

Climatic and biotic extreme events can result in considerable damage to arctic vegetation, often at landscape and larger scale. These acute events therefore contribute to the browning observed in some arctic regions. It is of considerable concern, therefore, that such extreme events are increasing in frequency as part of climate change. However, despite the increasing importance of browning events, and the considerable impact they can have on ecosystems, to date there is little understanding of their impacts on ecosystem carbon fluxes. To address this, the impacts of a number of different, commonly occurring, extreme events and their subsequent browning (vegetation damage) on key ecosystem CO2 fluxes were assessed during the growing season at a range of event damaged sites of shrub dominated vegetation. Sites were located from the boreal to High Arctic (64˚N-79˚N) and had been previously been damaged by events of frost-drought, extreme winter warming, ground icing and caterpillar (Epirrita autumnata) outbreaks. Plot-level CO2 fluxes of Ecosystem Exchange (NEE), Gross Primary Productivity (GPP) and Ecosystem Respiration (Reco) were assessed using vegetation chambers. At a sub-set of sites, NDVI (greenness) in flux plots was also assessed by hand-held proximal sensor, allowing the relationship between NDVI of damage plots to CO2 flux to be calculated. Despite the contrasting sites and drivers, damage had consistent, major impacts on all fluxes. All sites showed reductions in GPP and NEE with increasing damage, despite efflux from Reco also declining with damage. When scaled to site-level, reductions of up to 81% of NEE, 51% of GPP and 37% of Reco were observed. In the plot-level NDVI-flux relationship, NDVI was shown to explain up to 91% of variation in GPP, and therefore supports the use of NDVI for estimating changes in ecosystem CO2 flux at larger scales in regions where browning has been driven by extreme events. This work is the first attempt to quantify the impacts of different event drivers of arctic browning on the main ecosystem CO2 fluxes at a range of sites. These insights provide an important step towards incorporating extreme events into our understanding of how ecosystem CO2 balance at high latitudes will respond to continuing climate change.

Mean and extreme sea level changes in the southwestern Baltic Sea

NASA Astrophysics Data System (ADS)

Schmidt, Jessica; Patzke, Justus; Dangendorf, Sönke; Arns, Arne; Jensen, Jürgen; Fröhle, Peter

2016-04-01

In this contribution an overview over the BMBF project AMSeL_Ostsee (2015-2018) for the assessment of mean and extreme sea level changes over the past 150 years in the southwestern Baltic Sea is presented. We compile several high resolution tide gauge records provided by the Water and Shipping Administration (WSV) along the German Baltic Sea coastline and merge them in internationally available data bases (UHSLC, PSMSL, and data officially available at national authorities). In addition, we make efforts in digitizing historical records to expand the number of available data sets in this complex and vulnerable coastal region. To separate absolute from relative long-term changes in sea level the vertical land motion (VLM) at specific sites is assessed. Possible sources of VLM are independently assessed by using different state-of-the-art approaches, that is: Glacial Isostatic Adjustment (GIA) modelled by viscoelastic Earth models, GPS derived VLM, and the difference between tide gauge and nearby satellite altimetry. The VLM corrected tide gauge records are further assessed for linear and non-linear trends as well as possible acceleration/deceleration patterns by applying advanced time series models such as Singular System Analysis (SSA) combined with a Monte-Carlo-Autoregressive-Padding approach (Wahl et al., 2010). These trend assessments are applied to mean and extreme sea levels independently to prove whether observed changes in extremes are either due to an underlying trend on mean sea levels or changes in storminess. References: Wahl, T., Jensen, J., Frank, T. (2011): On analysing sea level rise in the German Bight since 1844, NHESS, 10, 171-179.

A comparison of two global datasets of extreme sea levels and resulting flood exposure

NASA Astrophysics Data System (ADS)

Muis, Sanne; Verlaan, Martin; Nicholls, Robert J.; Brown, Sally; Hinkel, Jochen; Lincke, Daniel; Vafeidis, Athanasios T.; Scussolini, Paolo; Winsemius, Hessel C.; Ward, Philip J.

2017-04-01

Estimating the current risk of coastal flooding requires adequate information on extreme sea levels. For over a decade, the only global data available was the DINAS-COAST Extreme Sea Levels (DCESL) dataset, which applies a static approximation to estimate extreme sea levels. Recently, a dynamically derived dataset was developed: the Global Tide and Surge Reanalysis (GTSR) dataset. Here, we compare the two datasets. The differences between DCESL and GTSR are generally larger than the confidence intervals of GTSR. Compared to observed extremes, DCESL generally overestimates extremes with a mean bias of 0.6 m. With a mean bias of -0.2 m GTSR generally underestimates extremes, particularly in the tropics. The Dynamic Interactive Vulnerability Assessment model is applied to calculate the present-day flood exposure in terms of the land area and the population below the 1 in 100-year sea levels. Global exposed population is 28% lower when based on GTSR instead of DCESL. Considering the limited data available at the time, DCESL provides a good estimate of the spatial variation in extremes around the world. However, GTSR allows for an improved assessment of the impacts of coastal floods, including confidence bounds. We further improve the assessment of coastal impacts by correcting for the conflicting vertical datum of sea-level extremes and land elevation, which has not been accounted for in previous global assessments. Converting the extreme sea levels to the same vertical reference used for the elevation data is shown to be a critical step resulting in 39-59% higher estimate of population exposure.

Using Free Internet Videogames in Upper Extremity Motor Training for Children with Cerebral Palsy

PubMed Central

Sevick, Marisa; Eklund, Elizabeth; Mensch, Allison; Foreman, Matthew; Standeven, John; Engsberg, Jack

2016-01-01

Movement therapy is one type of upper extremity intervention for children with cerebral palsy (CP) to improve function. It requires high-intensity, repetitive and task-specific training. Tedium and lack of motivation are substantial barriers to completing the training. An approach to overcome these barriers is to couple the movement therapy with videogames. This investigation: (1) tested the feasibility of delivering a free Internet videogame upper extremity motor intervention to four children with CP (aged 8–17 years) with mild to moderate limitations to upper limb function; and (2) determined the level of intrinsic motivation during the intervention. The intervention used free Internet videogames in conjunction with the Microsoft Kinect motion sensor and the Flexible Action and Articulated Skeleton Toolkit software (FAAST) software. Results indicated that the intervention could be successfully delivered in the laboratory and the home, and pre- and post- impairment, function and performance assessments were possible. Results also indicated a high level of motivation among the participants. It was concluded that the use of inexpensive hardware and software in conjunction with free Internet videogames has the potential to be very motivating in helping to improve the upper extremity abilities of children with CP. Future work should include results from additional participants and from a control group in a randomized controlled trial to establish efficacy. PMID:27338485

Coherence between coastal and river flooding along the California coast

USGS Publications Warehouse

Odigie, Kingsley O.; Warrick, Jonathan

2018-01-01

Water levels around river mouths are intrinsically determined by sea level and river discharge. If storm-associated coastal water-level anomalies coincide with extreme river discharge, landscapes near river mouths will be flooded by the hydrodynamic interactions of these two water masses. Unfortunately, the temporal relationships between ocean and river water masses are not well understood. The coherence between extreme river discharge and coastal water levels at six California river mouths across different climatic and geographic regions was examined. Data from river gauges, wave buoys, and tide gauges from 2007 to 2014 were integrated to investigate the relationships between extreme river discharge and coastal water levels near the mouths of the Eel, Russian, San Lorenzo, Ventura, Arroyo Trabuco, and San Diego rivers. Results indicate that mean and extreme coastal water levels during extreme river discharge are significantly higher compared with background conditions. Elevated coastal water levels result from the combination of nontidal residuals (NTRs) and wave setups. Mean and extreme (>99th percentile of observations) NTRs are 3–20 cm and ∼30 cm higher during extreme river discharge conditions, respectively. Mean and extreme wave setups are up to 40 cm and ∼20–90 cm higher during extreme river discharge than typical conditions, respectively. These water-level anomalies were generally greatest for the northern rivers and least for the southern rivers. Time-series comparisons suggest that increases in NTRs are largely coherent with extreme river discharge, owing to the low atmospheric pressure systems associated with storms. The potential flooding risks of the concurrent timing of these water masses are tempered by the mixed, semidiurnal tides of the region that have amplitudes of 2–2.5 m. In summary, flooding hazard assessments for floodplains near California river mouths for current or future conditions with sea-level rise should include the temporal coherence of fluvial and oceanic water levels.

Agreeableness and alcohol-related aggression: the mediating effect of trait aggressivity.

PubMed

Miller, Cameron A; Parrott, Dominic J; Giancola, Peter R

2009-12-01

This study investigated the mediating effect of trait aggressivity on the relation between agreeableness and alcohol-related aggression in a laboratory setting. Participants were 116 healthy male social drinkers between 21 and 30 years of age. Agreeableness and trait aggressivity were measured using the Big Five Inventory and the Buss-Perry Aggression Questionnaire, respectively. Following the consumption of an alcohol or no-alcohol control beverage, participants completed a modified version of the Taylor Aggression Paradigm, in which electric shocks were received from and administered to a fictitious opponent during a competitive task. Aggression was operationalized as the proportion of the most extreme shocks delivered to the fictitious opponent under conditions of low and high provocation. Results indicated that lower levels of agreeableness were associated with higher levels of trait aggressivity. In turn, higher levels of trait aggressivity predicted extreme aggression in intoxicated, but not sober, participants under low, but not high, provocation. Findings highlight the importance of examining determinants of intoxicated aggression within a broader theoretical framework of personality.

[Results of selective posterior radiculetomy at the lumbar and cervical level].

PubMed

Vlahovitch, B; Fuentes, J M

1975-01-01

At the light of authors' present experience, radicletomy appears as an excellent antalgic operative procedure in the case of roots with high functional risk (brachial plexus and lumbar plexus). In the absence of any motor deficiency or ataxia, it appears that radicletomy is of help in the cure of severe hypertonies of the extremities (sequelae of cerebral stem contusions). Conversely, in the spastic sequelae of hemi- or paraparesias, lumbar-sacral posterior selective radicotomy is a sure procedure that procures results nearly super-imposable to radicletomy with an appreciable gain in time. At last, for what concerns the motor involvements of the upper extremity ending in spasticity, selective radicletomy recovers its rights and has to be preferred to S.P.R. The indications may be summarized as follows: -- At the level of the lower extremities: in the case of paraparetic sequelae or of sequelae due to spastic paraplegia, a S.P.R. has to be performed; for what concerns antalgic surgery, in the absence of motor deficiency, the best indication is radicletomy. -- At the level of the upper extremities: in the case of dystonic sequeale of the cerebral stem, spastic pain bound with hemiplegia or with carcinoma etc. (herpes zoster..), radicletomy constitutes the ideal surgical procedure.

Using damage data to estimate the risk from summer convective precipitation extremes

NASA Astrophysics Data System (ADS)

Schroeer, Katharina; Tye, Mari

2017-04-01

This study explores the potential added value from including loss and damage data to understand the risks from high-intensity short-duration convective precipitation events. Projected increases in these events are expected even in regions that are likely to become more arid. Such high intensity precipitation events can trigger hazardous flash floods, debris flows, and landslides that put people and local assets at risk. However, the assessment of local scale precipitation extremes is hampered by its high spatial and temporal variability. In addition to this, not only are extreme events rare, but such small-scale events are likely to be underreported where they do not coincide with the observation network. Reports of private loss and damage on a local administrative unit scale (LAU 2 level) are used to explore the relationship between observed rainfall events and damages reportedly related to hydro-meteorological processes. With 480 Austrian municipalities located within our south-eastern Alpine study region, the damage data are available on a much smaller scale than the available rainfall data. Precipitation is recorded daily at 185 gauges and 52% of these stations additionally deliver sub-hourly rainfall information. To obtain physically plausible information, damage and rainfall data are grouped and analyzed on a catchment scale. The data indicate that rainfall intensities are higher on days that coincide with a damage claim than on days for which no damage was reported. However, approximately one third of the damages related to hydro-meteorological hazards were claimed on days for which no rainfall was recorded at any gauge in the respective catchment. Our goal is to assess whether these events indicate potential extreme events missing in the observations. Damage always is a consequence of an asset being exposed and susceptible to a hazardous process, and naturally, many factors influence whether an extreme rainfall event causes damage. We set up a statistical model to test whether the relationship between extreme rainfall events and damages is robust enough to estimate a potential underrepresentation of high intensity rainfall events in ungauged areas. Risk-relevant factors of socio-economic vulnerability, land cover, streamflow data, and weather type information are included to improve and sharpen the analysis. Within this study, we first aim to identify which rainfall events are most damaging and which factors affect the damages - seen as a proxy for the vulnerability - related to summer convective rainfall extremes in different catchment types. Secondly, we aim to detect potentially unreported damaging rainfall events and estimate the likelihood of such cases. We anticipate this damage perspective on summertime extreme convective precipitation to be beneficial for risk assessment, uncertainty management, and decision making with respect to weather and climate extremes on the regional-to-local level.

Cumulative hazard: The case of nuisance flooding

NASA Astrophysics Data System (ADS)

Moftakhari, Hamed R.; AghaKouchak, Amir; Sanders, Brett F.; Matthew, Richard A.

2017-02-01

The cumulative cost of frequent events (e.g., nuisance floods) over time may exceed the costs of the extreme but infrequent events for which societies typically prepare. Here we analyze the likelihood of exceedances above mean higher high water and the corresponding property value exposure for minor, major, and extreme coastal floods. Our results suggest that, in response to sea level rise, nuisance flooding (NF) could generate property value exposure comparable to, or larger than, extreme events. Determining whether (and when) low cost, nuisance incidents aggregate into high cost impacts and deciding when to invest in preventive measures are among the most difficult decisions for policymakers. It would be unfortunate if efforts to protect societies from extreme events (e.g., 0.01 annual probability) left them exposed to a cumulative hazard with enormous costs. We propose a Cumulative Hazard Index (CHI) as a tool for framing the future cumulative impact of low cost incidents relative to infrequent extreme events. CHI suggests that in New York, NY, Washington, DC, Miami, FL, San Francisco, CA, and Seattle, WA, a careful consideration of socioeconomic impacts of NF for prioritization is crucial for sustainable coastal flood risk management.

A comparative assessment of statistical methods for extreme weather analysis

NASA Astrophysics Data System (ADS)

Schlögl, Matthias; Laaha, Gregor

2017-04-01

Extreme weather exposure assessment is of major importance for scientists and practitioners alike. We compare different extreme value approaches and fitting methods with respect to their value for assessing extreme precipitation and temperature impacts. Based on an Austrian data set from 25 meteorological stations representing diverse meteorological conditions, we assess the added value of partial duration series over the standardly used annual maxima series in order to give recommendations for performing extreme value statistics of meteorological hazards. Results show the merits of the robust L-moment estimation, which yielded better results than maximum likelihood estimation in 62 % of all cases. At the same time, results question the general assumption of the threshold excess approach (employing partial duration series, PDS) being superior to the block maxima approach (employing annual maxima series, AMS) due to information gain. For low return periods (non-extreme events) the PDS approach tends to overestimate return levels as compared to the AMS approach, whereas an opposite behavior was found for high return levels (extreme events). In extreme cases, an inappropriate threshold was shown to lead to considerable biases that may outperform the possible gain of information from including additional extreme events by far. This effect was neither visible from the square-root criterion, nor from standardly used graphical diagnosis (mean residual life plot), but from a direct comparison of AMS and PDS in synoptic quantile plots. We therefore recommend performing AMS and PDS approaches simultaneously in order to select the best suited approach. This will make the analyses more robust, in cases where threshold selection and dependency introduces biases to the PDS approach, but also in cases where the AMS contains non-extreme events that may introduce similar biases. For assessing the performance of extreme events we recommend conditional performance measures that focus on rare events only in addition to standardly used unconditional indicators. The findings of this study are of relevance for a broad range of environmental variables, including meteorological and hydrological quantities.

Identifying evidence of climate change impact on extreme events in permeable chalk catchments

NASA Astrophysics Data System (ADS)

Butler, A. P.; Nubert, S.

2009-12-01

The permeable chalk catchments of southern England are vital for the economy and well being of the UK. Not only important as a water resource, their freely draining soils support intensive agricultural production, and the rolling downs and chalk streams provide important habitants for many protected plant and animal species. Consequently, there are concerns about the potential impact of climate change on such catchments, particularly in relation to groundwater recharge. Of major concern are possible changes in extreme events, such as groundwater floods and droughts, as any increase in the frequency and/or severity of these has important consequences for water resources, ecological systems and local infrastructure. Studies of climate change impact on extreme events for such catchments have indicated that, under medium and high emissions scenarios, droughts are likely to become more severe whilst floods less so. However, given the uncertainties in such predictions and the inherent variability in historic data, producing definitive evidence of changes in flood/drought frequency/severity poses a significant challenge. Thus, there is a need for specific extreme event statistics that can be used as indicators of actual climate change in streamflow and groundwater level observations. Identifying such indicators that are sufficiently robust requires catchments with long historic time series data. One such catchment is the River Lavant, an intermittent chalk stream in West Sussex, UK. Located within this catchment is Chilgrove House, the site of the UK’s longest groundwater monitoring well (with a continuous record of water level observations of varying frequency dating back to 1836). Using a variety of meteorological datasets, the behaviour of the catchment has been modelled, from 1855 to present, using a 'leaky aquifer' conceptual model. Model calibration was based on observed daily streamflow, at a gauging station just outside the town of Chichester, from 1970. Long-term performance was assessed using groundwater levels at various long period observation wells, including Chilgrove. Extreme event analyses (annual maximum daily flow, annual minimum groundwater level) based on historic model runs, looking at successive 30 year time periods, show high variability in the values of extreme events, However, there is far less (by an order of magnitude) variation in more frequent (i.e. less extreme) events with a recurrence interval of around 0.6 (i.e. a return period of around 1.67 years). Simulations of climate change impact for 2020 emission scenarios using UKCIP02 data give 0.6 recurrence estimates that are significantly different (at the 1% confidence level) than those obtained from historic data, which is not the case for more extreme events. It is proposed that, at least for such permeable catchments, deviations from historic values of this relatively frequent recurrence interval provide a more robust indicator for detecting evidence of climate change than focusing on much rarer, albeit more dramatic, events.

Understanding extreme sea levels for coastal impact and adaptation analysis

NASA Astrophysics Data System (ADS)

Wahl, T.; Haigh, I. D.; Nicholls, R. J.; Arns, A.; Hinkel, J.; Dangendorf, S.; Slangen, A.

2016-12-01

Coastal impact and adaptation assessments require detailed knowledge on extreme sea levels, because increasing damage due to extreme events, such as storm surges and tropical cyclones, is one of the major consequences of sea level rise and climate change. In fact, the IPCC has highlighted in its AR4 report that "societal impacts of sea level change primarily occur via the extreme levels rather than as a direct consequence of mean sea level changes". Over the last few decades, substantial research efforts have been directed towards improved understanding of past and future mean sea level; different scenarios were developed with process-based or semi-empirical models and used for coastal impact assessments at various spatial scales to guide coastal management and adaptation efforts. The uncertainties in future sea level rise are typically accounted for by analyzing the impacts associated with a range of scenarios leading to a vertical displacement of the distribution of extreme sea-levels. And indeed most regional and global studies find little or no evidence for changes in storminess with climate change, although there is still low confidence in the results. However, and much more importantly, there is still a limited understanding of present-day extreme sea-levels which is largely ignored in most impact and adaptation analyses. The two key uncertainties stem from: (1) numerical models that are used to generate long time series of extreme sea-levels. The bias of these models varies spatially and can reach values much larger than the expected sea level rise; but it can be accounted for in most regions making use of in-situ measurements; (2) Statistical models used for determining present-day extreme sea-level exceedance probabilities. There is no universally accepted approach to obtain such values for flood risk assessments and while substantial research has explored inter-model uncertainties for mean sea level, we explore here, for the first time, inter-model uncertainties for extreme sea-levels at large spatial scales and compare them to the uncertainties in mean sea level projections.

Immunosuppressive Therapy in Treatment of Refractory Hypoglycemia in Type B Insulin Resistance: A Case Report

PubMed Central

Sirisena, Imali

2017-01-01

Type B insulin resistance is a rare syndrome characterized by fluctuating glucose levels (ranging from hyperglycemia with extreme insulin resistance to intractable hypoglycemia without exogenous insulin administration), high serum insulin levels, and insulin receptor autoantibodies. Most cases occur in the African American population in association with other underlying autoimmune systemic diseases. Treatments with high-dose steroids, immunosuppressants, and plasmapheresis have been used, with variable outcomes, in patients without spontaneous remission. We report the case of a 60-year-old African American woman with history of systemic lupus erythematosus presenting with extreme fluctuations in glucose levels, ranging from severe hyperglycemia to refractory hypoglycemia, with high serum concentration of insulin in both phases. Her presentation and phenotype were very similar to those seen in known cases of type B insulin resistance associated with insulin receptor antibodies. Treatment in other reported cases used a combination of high-dose steroids and immunosuppressants. We tried high-dose steroids, azathioprine, and intravenous immunoglobulins, which resulted in improvement and barely detectable insulin receptor antibody. We present a case of type B insulin resistance with abnormally low titers of insulin receptor antibodies despite a typical clinical course and response. Future research is needed to improve diagnosis and treatment in this rare disease. PMID:29264467

Changes of the Oceanic Long-term and seasonal variation in a Global-warming Climate

NASA Astrophysics Data System (ADS)

Xia, Q.; He, Y.; Dong, C.

2015-12-01

Abstract: Gridded absolute dynamic topography (ADT) from AVISO and outputs of sea surface height above geoid from a series of climate models run for CMIP5 are used to analysis global sea level variation. Variance has been calculated to determine the magnitude of change in sea level variation over two decades. Increasing trend of variance of ADT suggests an enhanced fluctuation as well as geostrophic shear of global ocean. To further determine on what scale does the increasing fluctuation dominate, the global absolute dynamic topography (ADT) has been separated into two distinguished parts: the global five-year mean sea surface (MSS) and the residual absolute dynamic topography (RADT). Increased variance of MSS can be ascribed to the nonuniform rising of global sea level and an enhancement of ocean gyres in the Pacific Ocean. While trend in the variance of RADT is found to be close to zero which suggests an unchanged ocean mesoscale variability. The Gaussian-like distribution of global ADT are used to study the change in extreme sea levels. Information entropy has also been adapted in our study. Increasing trend of information entropy which measures the degree of dispersion of a probability distribution suggests more appearance of extreme sea levels. Extreme high sea levels are increasing with a higher growing rate than the mean sea level rise.

Do patients with ewing's sarcoma continue with sports activities after limb salvage surgery of the lower extremity?

PubMed

Hobusch, Gerhard Martin; Lang, Nikolaus; Schuh, Reinhard; Windhager, Reinhard; Hofstaetter, Jochen Gerhard

2015-03-01

Limb salvage surgery has evolved to become the standard method of treating sarcomas of the extremities with acceptable oncologic results. However, little information exists relative to the activity level or ability to participate in sports after tumor reconstructions. The aims of the study were to answer the following questions: (1) Which sports activity levels and what types of sports can be expected in the long term after tumor reconstruction? (2) Which frequency durations are patients with Ewing's sarcoma able to perform in long-term followup after local control? (3) Do surgical complications affect sports activity level? Thirty patients (13 females, 17 males; mean age, 18 ± 8 years; range, 2-36 years at diagnosis; mean followup 16 ± 6 years [minimum, 5 years]) were included. Tumors were located in the pelvis, femur, tibia, and fibula. Surgical procedures included surgical resections alone (n = 8), surgical resection with biological reconstruction (n = 9), or endoprosthetic reconstruction (n = 13). We assessed UCLA sports activity levels, kinds of sports as well as the frequency per week and the duration of each training unit at long term (minimum followup, 5 years). In long-term followup 83% patients (25 of 30) were performing athletic activity regularly. The hours/week of sports depended on type of surgery and were highest after resections in the pelvis and femur (5.8) and were lowest after megaprosthetic reconstruction of the pelvis (1.0). Patients undergoing biologic reconstructions were able to perform high-impact sports. UCLA sports activity levels were high after joint-preserving vascularized fibula for tibia reconstruction (7.4) and after megaprosthetic reconstruction of the lower extremity (6.3-6.4) and were low after tumors located in the fibula (4.2). Complications during followup did not significantly influence sports activity in long-term survivors. Long-term survivors can achieve high levels of sports activity in many instances. Tumor sites are associated with the postoperative sports activity levels. This information can help surgeons counsel patients in terms of athletic expectations after limb salvage reconstruction for patients with Ewing's sarcoma. Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

The effect of breast support and breast pain on upper-extremity kinematics during running: implications for females with large breasts.

PubMed

White, Jennifer; Mills, Chris; Ball, Nick; Scurr, Joanna

2015-01-01

The relationship between inappropriate breast support and upper-extremity kinematics for female runners is unclear. The purpose of this study was to investigate the effect of breast support and breast pain on upper-extremity kinematics during running. Eleven female recreational runners with larger breasts (UK D and E cup) completed a 7 min 20 s treadmill run (2.58 m · s(-1)) in a high and low breast support condition. Multi-planar breast and upper-extremity kinematic data were captured in each breast support condition by eight infrared cameras for 30 s towards the end of the run. Breast pain was rated at the end of each treadmill run using a numeric analogue scale. The high support bra reduced breast kinematics and decreased breast pain (P < 0.05). Upper-extremity kinematics did not differ between breast support conditions (P > 0.05), although some moderate positive correlations were found between thorax range of motion and breast kinematics (r = 0.54 to 0.73). Thorax and arm kinematics do not appear to be influenced by breast support level in female runners with large breasts. A high support bra that offers good multi-planar breast support is recommended for female runners with larger breasts to reduce breast pain.

Young planets under extreme UV irradiation. I. Upper atmosphere modelling of the young exoplanet K2-33b

NASA Astrophysics Data System (ADS)

Kubyshkina, D.; Lendl, M.; Fossati, L.; Cubillos, P. E.; Lammer, H.; Erkaev, N. V.; Johnstone, C. P.

2018-04-01

The K2-33 planetary system hosts one transiting 5 R⊕ planet orbiting the young M-type host star. The planet's mass is still unknown, with an estimated upper limit of 5.4 MJ. The extreme youth of the system (<20 Myr) gives the unprecedented opportunity to study the earliest phases of planetary evolution, at a stage when the planet is exposed to an extremely high level of high-energy radiation emitted by the host star. We perform a series of 1D hydrodynamic simulations of the planet's upper atmosphere considering a range of possible planetary masses, from 2 to 40 M⊕, and equilibrium temperatures, from 850 to 1300 K, to account for internal heating as a result of contraction. We obtain temperature profiles mostly controlled by the planet's mass, while the equilibrium temperature has a secondary effect. For planetary masses below 7-10 M⊕, the atmosphere is subject to extremely high escape rates, driven by the planet's weak gravity and high thermal energy, which increase with decreasing mass and/or increasing temperature. For higher masses, the escape is instead driven by the absorption of the high-energy stellar radiation. A rough comparison of the timescales for complete atmospheric escape and age of the system indicates that the planet is more massive than 10 M⊕.

Optimal regionalization of extreme value distributions for flood estimation

NASA Astrophysics Data System (ADS)

Asadi, Peiman; Engelke, Sebastian; Davison, Anthony C.

2018-01-01

Regionalization methods have long been used to estimate high return levels of river discharges at ungauged locations on a river network. In these methods, discharge measurements from a homogeneous group of similar, gauged, stations are used to estimate high quantiles at a target location that has no observations. The similarity of this group to the ungauged location is measured in terms of a hydrological distance measuring differences in physical and meteorological catchment attributes. We develop a statistical method for estimation of high return levels based on regionalizing the parameters of a generalized extreme value distribution. The group of stations is chosen by optimizing over the attribute weights of the hydrological distance, ensuring similarity and in-group homogeneity. Our method is applied to discharge data from the Rhine basin in Switzerland, and its performance at ungauged locations is compared to that of other regionalization methods. For gauged locations we show how our approach improves the estimation uncertainty for long return periods by combining local measurements with those from the chosen group.

Risk management for food and beverage industry using Australia/New Zealand 4360 Standard

NASA Astrophysics Data System (ADS)

Kristina, S.; Wijaya, B. M.

2017-12-01

This research aims to identifying, measuring and establishing risk in food and beverage industry. The risk management is implemented by referring to Australia/New Zealand 4360 Standard which has four phases such as problem formulation, risk analysis, risk characterization, and risk management. The implementation of risk management is done by case study at Back Alley Café. Based on the risk identification result, there are 59 risks were found in Back Alley Café. The risk identification is conducted based on observation and interview with the café manager who understand the condition of Back Alley Café properly. Based on the assessment of impact and probability, the risk mapping produced four risks at extreme level, 16 risks at high level, 24 risks at medium level, and 18 risks at low level. The strategy was designed as the risk mitigation after the risk mapping for the extreme and high level. The strategy which is given as the prevention or treatment of risk in Back Alley Café is divided into three. There are reducing the risk, sharing the risk and accepting the risk. The strategy is then implemented for each relevant activities.

Preventing lower extremity injury in elite orienteerers: study protocol for a randomised controlled trial

PubMed Central

Halvarsson, Bodil

2018-01-01

Background The high physical load associated with running through uneven terrain contributes toorienteerers being exposed to high injury risk, where the majority of injuries are located in the lower extremities. Specific training programmes have been effective at reducing injury risk in sports. Yet no trial has been conducted in elite orienteering. The aim of this study is to investigate the effectiveness of a specific training programme in preventing lower extremity injury in adult elite orienteerers. Study design Randomised controlled trial (RCT). Methods Seventy-two Swedish elite orienteerers, aged 18–40 years, are allocated to an intervention or control group. The intervention group performs four specific exercises, with three difficult levels intensified every second week over the first 4 weeks, targeting strength, flexibility and coordination of the lower extremity. The exercises are completed four times a week (10 min per session) in conjunction with normal training over 14 weeks. Injury data are collected every second week using a valid injury questionnaire distributed by text messages over 14 weeks. The primary outcome is number of substantial injuries in the lower extremity. The secondary outcomes are incidence of ankle sprains and the average substantial injury prevalence across 14 weeks. Discussion Due to high injury risk and lack of injury prevention trials in orienteering, an RCT investigating the effect of a specific exercise programme in preventing lower extremity injury is warranted. The results of this trial will be beneficial to orienteerers, clubs and federations, and increase our understanding on how lower extremity injuries can be prevented in a physically challenging sport. Trial registration number NCT03408925. PMID:29707231

The Great Plains low-level jet in 1.5C and 2C HAPPI simulations: Implications for changes in extreme climate events

NASA Astrophysics Data System (ADS)

Weaver, S. J.; Barcikowska, M. J.

2017-12-01

Global temperature targets have become the cornerstone for global climate policy discussions. Given the goal of the Paris Accord to limit the rise in global mean temperature to well below 2.0oC above pre-industrial levels, and pursue efforts toward the more ambitious 1.5oC goal, there is increasing focus in the climate science community on what the relative changes in regional climate extremes may be for these two scenarios. Despite the successes of major climate science modeling efforts, there is still a significant information gap regarding the regional and seasonal changes in some climate extremes over the U.S. as a function of these global mean temperature targets.During the spring and summer, large amounts of heat and moisture are transported northward into the central and eastern U.S. by the Great Plains Low-Level Jet (GPLLJ) - an atmospheric river which dominates the subcontinental scale climate variability during the warm half of the year. Accordingly, the GPLLJ and its vast spatiotemporal variability is highly influential over several types of extreme climate anomalies east of the Rocky Mountains, including, drought and pluvial events, tornadic activity, and the evolution of central U.S warming hole. Changes in the GPLLJ and its variability are probed from the perspective of several hundred climate realizations afforded by the availability of climate model experiments from the Half a degree additional warming, Prognosis, and Projected Impacts (HAPPI) effort - a suite of multi-model ensemble AMIP simulations forced by 1.5oC and 2oC levels of global warming. The multimodel analysis focuses on the variable magnitude of the seasonal changes in the mean GPLLJ and shifts in the extremes of the prominent modes of GPLLJ variability - both of which have implications for the future shifts in extreme climate events over the Great Plains, Midwest, and southeast regions of the U.S.

Projected changes in extreme precipitation over Scotland and Northern England using a high-resolution regional climate model

NASA Astrophysics Data System (ADS)

Chan, Steven C.; Kahana, Ron; Kendon, Elizabeth J.; Fowler, Hayley J.

2018-03-01

The UK Met Office has previously conducted convection-permitting climate simulations over the southern UK (Kendon et al. in Nat Clim Change 4:570-576, 2014). The southern UK simulations have been followed up by a new set of northern UK simulations using the same model configuration. Here we present the mean and extreme precipitation projections from these new simulations. Relative to the southern UK, the northern UK projections show a greater summertime increase of return levels and extreme precipitation intensity in both 1.5 km convection-permitting and 12 km convection-parameterised simulations, but this increase is against a backdrop of large decreases in summertime mean precipitation and precipitation frequency. Similar to the southern UK, projected change is model resolution dependent and the convection-permitting simulation projects a larger intensification. For winter, return level increases are somewhat lower than for the southern UK. Analysis of model biases highlight challenges in simulating the diurnal cycle over high terrain, sensitivity to domain size and driving-GCM biases, and quality issues of radar precipitation observations, which are relevant to the wider regional climate modelling community.

Flooding Risk for Coastal Infrastructure: a Stakeholder-Oriented Approach

NASA Astrophysics Data System (ADS)

Plater, A. J.; Prime, T.; Brown, J. M.; Knight, P. J.; Morrissey, K.

2015-12-01

A flood risk assessment for coastal energy infrastructure in the UK with respect to long-term sea-level rise and extreme water levels has been conducted using a combination of numerical modelling approaches (LISFLOOD-FP, SWAB, XBeach-G, POLCOMS). Model outputs have been incorporated into a decision-support tool that enables users from a wide spectrum of coastal stakeholders (e.g. nuclear energy, utility providers, local government, environmental regulators, communities) to explore the potential impacts of flooding on both operational (events to 10 years) and strategic (10 to 50 years) timescales. Examples illustrate the physical and economic impacts of flooding from combined extreme water levels, wave overtopping and high river flow for Fleetwood, NW England; changes in the extent of likely flooding arising from an extreme event due to sea-level rise for Oldbury, SW England; and the relative vulnerability to overtopping and breaching of sea defences for Dungeness, SE England. The impacts of a potential large-scale beach recharge scheme to mitigate coastal erosion and flood risk along the southern shoreline of Dungeness are also examined using a combination of coastal evolution and particle-tracking modelling. The research goal is to provide an evidence base for resource allocation, investment in interventions, and communication and dialogue in relation to sea-level rise to 2500 AD.

Advanced Extremely High Frequency Satellite (AEHF)

DTIC Science & Technology

2015-12-01

control their tactical and strategic forces at all levels of conflict up to and including general nuclear war, and it supports the attainment of...10195.1 10622.2 Confidence Level Confidence Level of cost estimate for current APB: 50% The ICE) that supports the AEHF SV 1-4, like all life-cycle cost...mathematically the precise confidence levels associated with life-cycle cost estimates prepared for MDAPs. Based on the rigor in methods used in building

Stellar atmosphere modeling of extremely hot, compact stars

NASA Astrophysics Data System (ADS)

Rauch, Thomas; Ringat, Ellen; Werner, Klaus

Present X-ray missions like Chandra and XMM-Newton provide excellent spectra of extremely hot white dwarfs, e.g. burst spectra of novae. Their analysis requires adequate NLTE model atmospheres. The Tuebingen Non-LTE Model-Atmosphere Package (TMAP) can calculate such model at-mospheres and spectral energy distributions at a high level of sophistication. We present a new grid of models that is calculated in the parameter range of novae and supersoft X-ray sources and show examples of their application.

Expert consensus on facilitators and barriers to return-to-work following surgery for non-traumatic upper extremity conditions: a Delphi study.

PubMed

Peters, S E; Johnston, V; Ross, M; Coppieters, M W

2017-02-01

This Delphi study aimed to reach consensus on important facilitators and barriers for return-to-work following surgery for non-traumatic upper extremity conditions. In Round 1, experts ( n = 42) listed 134 factors, which were appraised in Rounds 2 and 3. Consensus (⩾85% agreement) was achieved for 13 facilitators (high motivation to return-to-work; high self-efficacy for return-to-work and recovery; availability of modified/alternative duties; flexible return-to-work arrangements; positive coping skills; limited heavy work exertion; supportive return-to-work policies; supportive supervisor/management; no catastrophic thinking; no fear avoidance to return-to-work; no fear avoidance to pain/activity; return to meaningful work duties; high job satisfaction) and six barriers (mood disorder diagnosis; pain/symptoms at more than one musculoskeletal site; heavy upper extremity exertions at work; lack of flexible return-to-work arrangements; lack of support from supervisor/management; high level of pain catastrophizing). Future prognostic studies are required to validate these biopsychosocial factors to further improve return-to-work outcomes. V.

Recovery Act - CAREER: Sustainable Silicon -- Energy-Efficient VLSI Interconnect for Extreme-Scale Computing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiang, Patrick

2014-01-31

The research goal of this CAREER proposal is to develop energy-efficient, VLSI interconnect circuits and systems that will facilitate future massively-parallel, high-performance computing. Extreme-scale computing will exhibit massive parallelism on multiple vertical levels, from thou­ sands of computational units on a single processor to thousands of processors in a single data center. Unfortunately, the energy required to communicate between these units at every level (on­ chip, off-chip, off-rack) will be the critical limitation to energy efficiency. Therefore, the PI's career goal is to become a leading researcher in the design of energy-efficient VLSI interconnect for future computing systems.

G-Equivalent Acceleration Tolerance in the Eutardigrade Species Hypsibius dujardini.

PubMed

Vasanthan, Tarushika; Alejaldre, Lorea; Hider, Jessica; Patel, Shreya; Husain, Nabiha; Umapathisivam, Bavithra; Stone, Jonathon

2017-01-01

Tardigrades are microscopic organisms renowned for their ability to survive extreme environmental conditions. Tardigrade extreme-tolerance research has centered on the ability to withstand desiccation, low and high temperatures, and high hydrostatic pressure and radiation levels. Tardigrade tolerance to hypergravity, however, has yet to be described. We used the eutardigrade species Hypsibius dujardini to investigate short-term tolerance to g-equivalent accelerations (i.e., mimicking g-forces). Data obtained from specimens centrifuged between 3421g and 16,060g for 1 min inclusively reveal tolerance in an acceleration-dependent relation, with lower survivorship and egg production at higher accelerations. This is the first study to demonstrate tardigrade potential for tolerance to hypergravity and describe expected effects on tardigrade survival and reproduction. These findings will prove to be useful in lithopanspermia research (i.e., viable spread in meteoritic rocks). Key Words: Astrobiology-Extreme tolerance-Hypergravity-Tardigrade. Astrobiology 17, 55-60.

Rarefied flow diagnostics using pulsed high-current electron beams

NASA Technical Reports Server (NTRS)

Wojcik, Radoslaw M.; Schilling, John H.; Erwin, Daniel A.

1990-01-01

The use of high-current short-pulse electron beams in low-density gas flow diagnostics is introduced. Efficient beam propagation is demonstrated for pressure up to 300 microns. The beams, generated by low-pressure pseudospark discharges in helium, provide extremely high fluorescence levels, allowing time-resolved visualization in high-background environments. The fluorescence signal frequency is species-dependent, allowing instantaneous visualization of mixing flowfields.

On the differences between 1.5oC and 2oC of global warming

NASA Astrophysics Data System (ADS)

King, A.

2017-12-01

The Paris Agreement of 2015 has resulted in a drive to limit global warming to 2oC with an aim for a lower 1.5oC target. It is therefore vital that we understand some of the differences we would expect between these two levels of global warming. My research uses coupled climate model projections to investigate where and for what variables we can differentiate between worlds of 1.5oC and 2oC global warming. I place a particular focus on climate extremes and population exposure to those extremes. I have found that there are perceptible benefits in limiting global warming to 1.5oC as opposed to 2oC through reduced frequency and intensity of heat extremes, both over land and in ocean areas where thermal stress on coral has resulted in bleaching. Differences in high and low precipitation extremes between the 1.5oC and 2oC global warming levels are projected for some regions. I have also examined how "scalable" changes from the 1.5oC to 2oC level are. In areas of the world such as Eastern China I find that changes in anthropogenic aerosol concentrations will influence the level of change projected at 1.5oC and 2oC, such that past warming is likely to be a poor indicator of future changes. Overall, my research finds clear benefits to limiting global warming to 1.5oC relative to higher levels.

Islands in the sea: extreme female natal site fidelity in the Australian sea lion, Neophoca cinerea.

PubMed

Campbell, R A; Gales, N J; Lento, G M; Baker, C S

2008-02-23

Pinnipeds (seals, fur seals, sea lions and walrus) form large breeding aggregations with females often remaining faithful to a natal site or area. In these cases, females are philopatric to regional areas on broad geographical scales of hundreds to thousands of kilometers. An investigation of variation in a control region sequence of mtDNA in the Australian sea lion (Neophoca cinerea) has shown a case of extreme female natal site fidelity that has resulted in almost fixed population differentiation across its range (PhiST=0.93). This high level of population subdivision over short geographical distances (approx. 60 km) is unparalleled in any social marine mammal and reflects the unique life-history traits of this rare species. The high level of population subdivision and exclusive female natal site fidelity has important ramifications for conservation management, and poses many interesting questions of both academic and applied interest.

Nitrogen Accumulation and Partitioning in High Arctic Tundra from Extreme Atmospheric N Deposition Events

NASA Astrophysics Data System (ADS)

Phoenix, G. K.; Osborn, A.; Blaud, A.; Press, M. C.; Choudhary, S.

2013-12-01

Arctic ecosystems are threatened by pollution from extreme atmospheric nitrogen (N) deposition events. These events occur from the long-range transport of reactive N from pollution sources at lower latitudes and can deposit up to 80% of the annual N deposition in just a few days. To date, the fate and impacts of these extreme pollutant events has remained unknown. Using a field simulation study, we undertook the first assessment of the fate of acutely deposited N on arctic tundra. Extreme N deposition events were simulated on field plots at Ny-Ålesund, Svalbard (79oN) at rates of 0, 0.04, 0.4 and 1.2 g N m-2 yr-1 applied as NH4NO3 solution over 4 days, with 15N tracers used in the second year to quantify the fate of the deposited N in the plant, soil, microbial and leachate pools. Separate applications of 15NO3- and 15NH4+ were also made to determine the importance of N form in the fate of N. Recovery of the 15N tracer at the end of the first growing season approached 100% of the 15N applied irrespective of treatment level, demonstrating the considerable capacity of High Arctic tundra to capture pollutant N from extreme deposition events. Most incorporation of the 15N was found in bryophytes, followed by the dominant vascular plant (Salix polaris) and the microbial biomass of the soil organic layer. Total recovery remained high in the second growing season (average of 90%), indicating highly conservative N retention. Between the two N forms, recovery of 15NO3- and 15NH4+ were equal in the non-vascular plants, whereas in the vascular plants (particularly Salix polaris) recovery of 15NO3- was four times higher than of 15NH4+. Overall, these findings show that High Arctic tundra has considerable capacity to capture and retain the pollutant N deposited in acute extreme deposition events. Given they can represent much of the annual N deposition, extreme deposition events may be more important than increased chronic N deposition as a pollution source. Furthermore, current extreme N deposition events -and the predicted future increase in extreme deposition events- may represent an important source of eutrophication to 'pristine' arctic tundra.

Generation of multivariate near shore extreme wave conditions based on an extreme value copula for offshore boundary conditions.

NASA Astrophysics Data System (ADS)

Leyssen, Gert; Mercelis, Peter; De Schoesitter, Philippe; Blanckaert, Joris

2013-04-01

Near shore extreme wave conditions, used as input for numerical wave agitation simulations and for the dimensioning of coastal defense structures, need to be determined at a harbour entrance situated at the French North Sea coast. To obtain significant wave heights, the numerical wave model SWAN has been used. A multivariate approach was used to account for the joint probabilities. Considered variables are: wind velocity and direction, water level and significant offshore wave height and wave period. In a first step a univariate extreme value distribution has been determined for the main variables. By means of a technique based on the mean excess function, an appropriate member of the GPD is selected. An optimal threshold for peak over threshold selection is determined by maximum likelihood optimization. Next, the joint dependency structure for the primary random variables is modeled by an extreme value copula. Eventually the multivariate domain of variables was stratified in different classes, each of which representing a combination of variable quantiles with a joint probability, which are used for model simulation. The main variable is the wind velocity, as in the area of concern extreme wave conditions are wind driven. The analysis is repeated for 9 different wind directions. The secondary variable is water level. In shallow waters extreme waves will be directly affected by water depth. Hence the joint probability of occurrence for water level and wave height is of major importance for design of coastal defense structures. Wind velocity and water levels are only dependent for some wind directions (wind induced setup). Dependent directions are detected using a Kendall and Spearman test and appeared to be those with the longest fetch. For these directions, wind velocity and water level extreme value distributions are multivariately linked through a Gumbel Copula. These distributions are stratified into classes of which the frequency of occurrence can be calculated. For the remaining directions the univariate extreme wind velocity distribution is stratified, each class combined with 5 high water levels. The wave height at the model boundaries was taken into account by a regression with the extreme wind velocity at the offshore location. The regression line and the 95% confidence limits where combined with each class. Eventually the wave period is computed by a new regression with the significant wave height. This way 1103 synthetic events were selected and simulated with the SWAN wave model, each of which a frequency of occurrence is calculated for. Hence near shore significant wave heights are obtained with corresponding frequencies. The statistical distribution of the near shore wave heights is determined by sorting the model results in a descending order and accumulating the corresponding frequencies. This approach allows determination of conditional return periods. For example, for the imposed univariate design return periods of 100 years for significant wave height and 30 years for water level, the joint return period for a simultaneous exceedance of both conditions can be computed as 4000 years. Hence, this methodology allows for a probabilistic design of coastal defense structures.

Climate Sensitivity to Shallow Groundwater Dynamics Inferred from Historical Groundwater Level Observations and Climate Data

NASA Astrophysics Data System (ADS)

Seyoum, W. M.; Wahls, B.

2017-12-01

The effect of land surface processes (e.g., change in vegetation and snow cover, and change in soil moisture) on climate is well understood. However, the connection between shallow groundwater fluctuation and regional climate variability is still unresolved. This project focuses on sensitivity of climate to shallow groundwater dynamics by analyzing the impact of shallow groundwater on soil moisture and precipitation. The study use co-located measurements of daily soil moisture, depth to groundwater level (DGWL), and climate (precipitation (R) and air temperature) data. Statistical relationship between soil moisture and DGWL at different depth established. Frequency, mean and cumulative climate extremes (R90, R99, R < 1mm) examined and compared with depth to groundwater level information at Bellville station, IL. Result indicate soil moisture has a strong inverse relationship with depth to groundwater level (r -0.75) when DGWL is between 0 to 2 m (critical depth) depth from the ground. Beyond this depth, there is no statistically significant correlation or trend between soil moisture and GWL. Within this critical depth, soil moisture is more or less constant during wet days (R ≥ 1mm) even though DGWL is fluctuating. However, soil moisture decrease exponentially as DGWL declining during dry days (R < 1mm). Thus, soil moisture is highly likely dependent on groundwater feedback in the critical depth. Comparison of DGWL with frequency and cumulative of subsequent summer and fall extreme precipitation (DGWL leading by 4-7 months) indicate higher frequency and magnitude of extreme wet precipitation (Rm > 150 mm) occur when DGWL is within the critical depth. As DGWL decreases below 2 m, frequency and magnitude of extreme precipitation diminishes. On the other hand, DGWL has no significant relationship with subsequent extreme dry condition, there is no statistically significant trend between frequency of R < 1mm and DGWL. Generally, depth to groundwater level influence soil moisture within 0 to 2 m depth form the ground. Groundwater level close to the ground (0 - 2 m) seems likely influence subsequent extreme wet condition while not conclusive is the influence of declining groundwater level (beyond 2 m) to subsequent dry conditions. The result support the broad hypothesis that shallow groundwater can influence climate.

Amorphous silicon carbide coatings for extreme ultraviolet optics

NASA Technical Reports Server (NTRS)

Kortright, J. B.; Windt, David L.

1988-01-01

Amorphous silicon carbide films formed by sputtering techniques are shown to have high reflectance in the extreme ultraviolet spectral region. X-ray scattering verifies that the atomic arrangements in these films are amorphous, while Auger electron spectroscopy and Rutherford backscattering spectroscopy show that the films have composition close to stoichiometric SiC, although slightly C-rich, with low impurity levels. Reflectance vs incidence angle measurements from 24 to 1216 A were used to derive optical constants of this material, which are presented here. Additionally, the measured extreme ultraviolet efficiency of a diffraction grating overcoated with sputtered amorphous silicon carbide is presented, demonstrating the feasibility of using these films as coatings for EUV optics.

Extreme-scale Algorithms and Solver Resilience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dongarra, Jack

A widening gap exists between the peak performance of high-performance computers and the performance achieved by complex applications running on these platforms. Over the next decade, extreme-scale systems will present major new challenges to algorithm development that could amplify this mismatch in such a way that it prevents the productive use of future DOE Leadership computers due to the following; Extreme levels of parallelism due to multicore processors; An increase in system fault rates requiring algorithms to be resilient beyond just checkpoint/restart; Complex memory hierarchies and costly data movement in both energy and performance; Heterogeneous system architectures (mixing CPUs, GPUs,more » etc.); and Conflicting goals of performance, resilience, and power requirements.« less

Tree-Ring Dating of Extreme Lake Levels at the Subarctic?Boreal Interface

NASA Astrophysics Data System (ADS)

Bégin, Yves

2001-03-01

The dates of extreme water levels of two large lakes in northern Quebec have been recorded over the last century by ice scars on shoreline trees and sequences of reaction wood in shore trees tilted by wave erosion. Ice-scar chronologies indicate high water levels in spring, whereas tree-tilting by waves is caused by summer high waters. A major increase in both the amplitude and frequency of ice floods occurred in the 1930s. No such change was indicated by the tree-tilting chronologies, but wave erosion occurred in exceptionally rainy years. According to the modern record, spring lake-level rise is due to increased snowfalls since the 1930s. However, the absence of erosional marks in a large number of years since 1930 suggests a high frequency of low-water-level years resulting from dry conditions. Intercalary years with very large numbers of marked trees (e.g., 1935) indicate that the interannual range of summer lake levels has increased since the 1930s. Increased lake-flood frequency is postulated to be related to a slower expansion of arctic anticyclones, favoring the passage of cyclonic air masses over the area and resulting in abundant snowfall in early winter. Conditions in summer are due to the rate of weakening of the anticyclones controlling the position of the arctic front in summer. This position influences the path of the cyclonic air masses, which control summer precipitation and, consequently, summer lake levels in the area.

How Much Hope Is Enough? Levels of Hope and Students' Psychological and School Functioning

ERIC Educational Resources Information Center

Marques, Susana C.; Lopez, Shane J.; Fontaine, Anne Marie; Coimbra, Susana; Mitchell, Joanna

2015-01-01

This study investigated the characteristics of students who report extremely high levels of hope. A sample of 682 students (ages 11-17) completed measures of hope, school engagement, life satisfaction, self-worth, and mental health. Academic achievement was obtained from students' school records. Based on their hope scores, students were divided…

The Portuguese Literacy Campaigns after the Carnation Revolution (1974-1977)

ERIC Educational Resources Information Center

Gomes, Isabel Pereira; Amorim, José Pedro; Correia, José Alberto; Menezes, Isabel

2015-01-01

This article presents a description of the major campaigns of adult literacy in the revolutionary period in Portugal, between the years 1974 and 1977. The campaigns aimed to address the problem of extremely low levels of formal education and high levels of adult illiteracy, and were organized by different movements, from the military to political…

Suction is kid's play: extremely fast suction in newborn seahorses.

PubMed

Van Wassenbergh, Sam; Roos, Gert; Genbrugge, Annelies; Leysen, Heleen; Aerts, Peter; Adriaens, Dominique; Herrel, Anthony

2009-04-23

Ongoing anatomical development typically results in a gradual maturation of the feeding movements from larval to adult fishes. Adult seahorses are known to capture prey by rotating their long-snouted head extremely quickly towards prey, followed by powerful suction. This type of suction is powered by elastic recoil and requires very precise coordination of the movements of the associated feeding structures, making it an all-or-none phenomenon. Here, we show that newborn Hippocampus reidi are able to successfully feed using an extremely rapid and powerful snout rotation combined with a high-volume suction, surpassing that observed in adult seahorses. An inverse dynamic analysis shows that an elastic recoil mechanism is also used to power head rotation in newborn H. reidi. This illustrates how extreme levels of performance in highly complex musculoskeletal systems can be present at birth given a delayed birth and rapid development of functionally important structures. The fact that the head skeleton of newborn seahorses is still largely cartilaginous may not be problematic because the hydrodynamic stress on the rotating snout appeared considerably lower than in adult syngnathids.

Suction is kid's play: extremely fast suction in newborn seahorses

PubMed Central

Van Wassenbergh, Sam; Roos, Gert; Genbrugge, Annelies; Leysen, Heleen; Aerts, Peter; Adriaens, Dominique; Herrel, Anthony

2009-01-01

Ongoing anatomical development typically results in a gradual maturation of the feeding movements from larval to adult fishes. Adult seahorses are known to capture prey by rotating their long-snouted head extremely quickly towards prey, followed by powerful suction. This type of suction is powered by elastic recoil and requires very precise coordination of the movements of the associated feeding structures, making it an all-or-none phenomenon. Here, we show that newborn Hippocampus reidi are able to successfully feed using an extremely rapid and powerful snout rotation combined with a high-volume suction, surpassing that observed in adult seahorses. An inverse dynamic analysis shows that an elastic recoil mechanism is also used to power head rotation in newborn H. reidi. This illustrates how extreme levels of performance in highly complex musculoskeletal systems can be present at birth given a delayed birth and rapid development of functionally important structures. The fact that the head skeleton of newborn seahorses is still largely cartilaginous may not be problematic because the hydrodynamic stress on the rotating snout appeared considerably lower than in adult syngnathids. PMID:19324657

A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer☆

PubMed Central

Costello, Leslie C.; Franklin, Renty B.

2016-01-01

The human prostate gland contains extremely high zinc levels; which is due to the specialized zinc-accumulating acinar epithelial of the peripheral zone. These cells evolved for their unique capability to produce and secrete extremely levels of citrate, which is achieved by the high cellular zinc level effects on the cell metabolism. This review highlights the specific functional and metabolic alterations that result from the accumulation of the high zinc levels, especially its effects on mitochondrial citrate metabolism and terminal oxidation. The implications of zinc in the development and progression of prostate cancer are described, which is the most consistent hallmark characteristic of prostate cancer. The requirement for decreased zinc resulting from down regulation of ZIP1 to prevent zinc cytotoxicity in the malignant cells is described as an essential early event in prostate oncogenesis. This provides the basis for the concept that an agent (such as the zinc ionophore, clioquinol) that facilitates zinc uptake and accumulation in ZIP1-deficient prostate tumors cells will markedly inhibit tumor growth. In the current absence of an efficacious chemotherapy for advanced prostate cancer, and for prevention of early development of malignancy; a zinc treatment regimen is a plausible approach that should be pursued. PMID:27132038

Nonstationary Extreme Value Analysis in a Changing Climate: A Software Package

NASA Astrophysics Data System (ADS)

Cheng, L.; AghaKouchak, A.; Gilleland, E.

2013-12-01

Numerous studies show that climatic extremes have increased substantially in the second half of the 20th century. For this reason, analysis of extremes under a nonstationary assumption has received a great deal of attention. This paper presents a software package developed for estimation of return levels, return periods, and risks of climatic extremes in a changing climate. This MATLAB software package offers tools for analysis of climate extremes under both stationary and non-stationary assumptions. The Nonstationary Extreme Value Analysis (hereafter, NEVA) provides an efficient and generalized framework for analyzing extremes using Bayesian inference. NEVA estimates the extreme value parameters using a Differential Evolution Markov Chain (DE-MC) which utilizes the genetic algorithm Differential Evolution (DE) for global optimization over the real parameter space with the Markov Chain Monte Carlo (MCMC) approach and has the advantage of simplicity, speed of calculation and convergence over conventional MCMC. NEVA also offers the confidence interval and uncertainty bounds of estimated return levels based on the sampled parameters. NEVA integrates extreme value design concepts, data analysis tools, optimization and visualization, explicitly designed to facilitate analysis extremes in geosciences. The generalized input and output files of this software package make it attractive for users from across different fields. Both stationary and nonstationary components of the package are validated for a number of case studies using empirical return levels. The results show that NEVA reliably describes extremes and their return levels.

Flying high: a theoretical analysis of the factors limiting exercise performance in birds at altitude.

PubMed

Scott, Graham R; Milsom, William K

2006-11-01

The ability of some bird species to fly at extreme altitude has fascinated comparative respiratory physiologists for decades, yet there is still no consensus about what adaptations enable high altitude flight. Using a theoretical model of O(2) transport, we performed a sensitivity analysis of the factors that might limit exercise performance in birds. We found that the influence of individual physiological traits on oxygen consumption (Vo2) during exercise differed between sea level, moderate altitude, and extreme altitude. At extreme altitude, haemoglobin (Hb) O(2) affinity, total ventilation, and tissue diffusion capacity for O(2) (D(To2)) had the greatest influences on Vo2; increasing these variables should therefore have the greatest adaptive benefit for high altitude flight. There was a beneficial interaction between D(To2) and the P(50) of Hb, such that increasing D(To2) had a greater influence on Vo2 when P(50) was low. Increases in the temperature effect on P(50) could also be beneficial for high flying birds, provided that cold inspired air at extreme altitude causes a substantial difference in temperature between blood in the lungs and in the tissues. Changes in lung diffusion capacity for O(2), cardiac output, blood Hb concentration, the Bohr coefficient, or the Hill coefficient likely have less adaptive significance at high altitude. Our sensitivity analysis provides theoretical suggestions of the adaptations most likely to promote high altitude flight in birds and provides direction for future in vivo studies.

[Hypercholesterolemia: a therapeutic approach].

PubMed

Moráis López, A; Lama More, R A; Dalmau Serra, J

2009-05-01

High blood cholesterol levels represent an important cardiovascular risk factor. Hypercholesterolemia is defined as levels of total cholesterol and low-density lipoprotein cholesterol above 95th percentile for age and gender. For the paediatric population, selective screening is recommended in children older than 2 years who are overweight, with a family history of early cardiovascular disease or whose parents have high cholesterol levels. Initial therapeutic approach includes diet therapy, appropriate physical activity and healthy lifestyle changes. Drug treatment should be considered in children from the age of 10 who, after having followed appropriate diet recommendations, still have very high LDL-cholesterol levels or moderately high levels with concomitant risk factors. In case of extremely high LDL-cholesterol levels, drug treatment should be taken into consideration at earlier ages (8 years old). Modest response is usually observed with bile acid-binding resins. Statins can be considered first-choice drugs, once evidence on their efficacy and safety has been shown.

Effects of El Niño-Southern Oscillation on sea level anomalies along the Gulf of Mexico coast

NASA Astrophysics Data System (ADS)

Kennedy, Andrew J.; Griffin, Melissa L.; Morey, Steven L.; Smith, Shawn R.; O'Brien, James J.

2007-05-01

Analyses of daily sea level data show the impacts of El Niño-Southern Oscillation (ENSO) in the Gulf of Mexico (GOM). Data from three stations (St. Petersburg, Florida, Pensacola, Florida, and Galveston, Texas), all of which have at least 50 years of daily observations, are processed to identify the interannual signals. Although low frequency (interannual) signals in the sea level anomaly time series are not clearly evident, a low frequency modulation of the extreme anomaly events (upper 10% or lower 10% of the distributions) is identified. Results show that sea level variability is seasonally dependent at all stations, with maximum variability in the winter months. In the eastern GOM, low sea level events in the winter months are more frequent during El Niño (warm phase) conditions when compared to a neutral ENSO phase. This is consistent with ENSO-related changes in the location where extratropical atmospheric low pressure systems form and in the tracks of these weather systems. The impacts of tropical systems in the summer through early fall months on coastal sea level in the GOM are shown by infrequent extreme high and low anomalies coinciding with individual storms. However, the number of storms affecting the data record from a particular sea level station is too small to confirm ENSO-related variability. Statistical methods are employed to demonstrate a significant link between extreme sea level anomalies in the GOM and ENSO during the October to March period.

Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways.

PubMed

Giacopuzzi, Edoardo; Gennarelli, Massimo; Minelli, Alessandra; Gardella, Rita; Valsecchi, Paolo; Traversa, Michele; Bonvicini, Cristian; Vita, Antonio; Sacchetti, Emilio; Magri, Chiara

2017-01-01

Inbreeding is a known risk factor for recessive Mendelian diseases and previous studies have suggested that it could also play a role in complex disorders, such as psychiatric diseases. Recent inbreeding results in the presence of long runs of homozygosity (ROHs) along the genome, which are also defined as autozygosity regions. Genetic variants in these regions have two alleles that are identical by descent, thus increasing the odds of bearing rare recessive deleterious mutations due to a homozygous state. A recent study showed a suggestive enrichment of long ROHs in schizophrenic patients, suggesting that recent inbreeding could play a role in the disease. To better understand the impact of autozygosity on schizophrenia risk, we selected, from a cohort of 180 Italian patients, seven subjects with extremely high numbers of large ROHs that were likely due to recent inbreeding and characterized the mutational landscape within their ROHs using Whole Exome Sequencing and, gene set enrichment analysis. We identified a significant overlap (17%; empirical p-value = 0.0171) between genes inside ROHs affected by low frequency functional homozygous variants (107 genes) and the group of most promising candidate genes mutated in schizophrenia. Moreover, in four patients, we identified novel and extremely rare damaging mutations in the genes involved in neurodevelopment (MEGF8) and in GABA/glutamatergic synaptic transmission (GAD1, FMN1, ANO2). These results provide insights into the contribution of rare recessive mutations and inbreeding as risk factors for schizophrenia. ROHs that are likely due to recent inbreeding harbor a combination of predisposing low-frequency variants and extremely rare variants that have a high impact on pivotal biological pathways implicated in the disease. In addition, this study confirms that focusing on patients with high levels of homozygosity could be a useful prioritization strategy for discovering new high-impact mutations in genetically complex disorders.

A Test-Length Correction to the Estimation of Extreme Proficiency Levels

ERIC Educational Resources Information Center

Magis, David; Beland, Sebastien; Raiche, Gilles

2011-01-01

In this study, the estimation of extremely large or extremely small proficiency levels, given the item parameters of a logistic item response model, is investigated. On one hand, the estimation of proficiency levels by maximum likelihood (ML), despite being asymptotically unbiased, may yield infinite estimates. On the other hand, with an…

Contemporary (post-Wills) survey of the views of Australian medical researchers: importance of funding, infrastructure and motivators for a research career.

PubMed

Shewan, Louise G; Glatz, Jane A; Bennett, Christine C; Coats, Andrew J S

To investigate the perceptions of Australian health and medical researchers 4 years after the Wills Report recommended and led to a substantial increase in health and medical research funding in Australia. A telephone poll of 501 active health and medical researchers, conducted between 28 April and 5 May, 2003. Researchers' views on the adequacy of funding, infrastructure and support, salary, community recognition, the excitement of discovery and research outcomes such as publication and patenting in research. Research funding was the most important concern: 91% of researchers (455/498) viewed funding as "very" or "extremely" important to their role, but only 10% (52/500) were "very" or "extremely" satisfied with the level of funding. Research infrastructure and support were seen as "very" or "extremely" important by 90% of researchers (449/501), while only 21% (104/501) were "very" or "extremely" satisfied. Researchers in medical research institutes were significantly more likely to be satisfied (27% [56/205] "very" or "extremely" satisfied) with the level of infrastructure and support than those working in universities (15% [41/268] "very" or "extremely" satisfied; P = 0.001). Among the factors that motivate researchers, the excitement of discovery stood out in terms of both high importance and satisfaction. Publications were viewed as more important research outcomes than patenting or commercial ventures. Funding and infrastructure support remain overwhelmingly researchers' greatest concerns. University-based researchers were less satisfied with infrastructure and support than those in independent medical research institutes.

Do cervical epidural injections provide long-term relief in neck and upper extremity pain? A systematic review.

PubMed

Manchikanti, Laxmaiah; Nampiaparampil, Devi E; Candido, Kenneth D; Bakshi, Sanjay; Grider, Jay S; Falco, Frank J E; Sehgal, Nalini; Hirsch, Joshua A

2015-01-01

The high prevalence of chronic persistent neck pain not only leads to disability but also has a significant economic, societal, and health impact. Among multiple modalities of treatments prescribed in the management of neck and upper extremity pain, surgical, interventional and conservative modalities have been described. Cervical epidural injections are also common modalities of treatments provided in managing neck and upper extremity pain. They are administered by either an interlaminar approach or transforaminal approach. To determine the long-term efficacy of cervical interlaminar and transforaminal epidural injections in the treatment of cervical disc herniation, spinal stenosis, discogenic pain without facet joint pain, and post surgery syndrome. The literature search was performed from 1966 to October 2014 utilizing data from PubMed, Cochrane Library, US National Guideline Clearinghouse, previous systematic reviews, and cross-references. The evidence was assessed based on best evidence synthesis with Level I to Level V. There were 7 manuscripts meeting inclusion criteria. Of these, 4 assessed the role of interlaminar epidural injections for managing disc herniation or radiculitis, and 3 assessed these injections for managing central spinal stenosis, discogenic pain without facet joint pain, and post surgery syndrome. There were 4 high quality manuscripts. A qualitative synthesis of evidence showed there is Level II evidence for each etiology category. The evidence is based on one relevant, high quality trial supporting the efficacy of cervical interlaminar epidural injections for each particular etiology. There were no randomized trials available assessing the efficacy of cervical transforaminal epidural injections. Paucity of available literature, specifically conditions other than disc herniation. This systematic review with qualitative best evidence synthesis shows Level II evidence for the efficacy of cervical interlaminar epidural injections with local anesthetic with or without steroids, based on at least one high-quality relevant randomized control trial in each category for disc herniation, discogenic pain without facet joint pain, central spinal stenosis, and post surgery syndrome.

Do causes of stress differ in their association with problem drinking by sex in Korean adolescents?

PubMed

Choi, Jae-Woo; Park, Eun-Cheol; Kim, Jae-Hyun; Park, So-Hee

2017-01-01

Previous studies have focused mainly on whether stress causes present drinking or excessive drinking. However, few studies have been conducted on the relationship between stress and problem drinking in adolescents. The objective of this study was to examine the stress level and the cause of stress related to problem drinking behavior according to sex among Korean youth. Data for this study were pooled from cross-sectional data collected annually from 2007 through 2012 from the Korea Youth Risk Behavior Web-based Survey. A representative sample of 442,113 students from 800 randomly selected middle and high schools in Korea were included. Multiple logistic regression models were used in the analysis. Both male and female students with extremely high stress were more likely to engage in problem drinking than were students with no stress (odds ratios [OR], 1.73 in males and 1.41 in females). The major causes of stress in male students that were associated with problem drinking were conflict with a teacher, trouble with parents, and peer relationships (ORs, 2.47, 1.72, and 1.71, respectively), whereas there are no statistically significant association between causes of stress and problem drinking among female students. Considering stress level, Male students with extremely high stress level were associated with problem drinking regardless of causes of stress, while Female students who felt extremely high levels of stress were more likely to engage in problem drinking due to stress from a conflict with parents, peer relationships, appearance, and financial difficulty (ORs, 1.53, 1.53, 1.46, and 1.47, respectively). Adolescents who engage in problem drinking may be affected by different causes of stress according to sex. Thus, appropriate approaches that reflect sex differences will be helpful to alleviate problem drinking in adolescents and educational authorities need to arrange more effective education program for drinking given positive associations between drinking education and problem drinking. Copyright © 2016. Published by Elsevier Ltd.

Flower morphology and floral sequence in Artemisia annua (Asteraceae)

USDA-ARS?s Scientific Manuscript database

Premise of the study: Artemisia annua produces phytochemicals possessing antimalarial, antitumor, anti-inflammatory, and anthelmintic activities. The main active ingredient, artemisinin, is extremely effective against malaria. Breeding to develop cultivars producing high levels of artemisinin can he...

Trends in the components of extreme water levels signal a rotation of winds in strong storms in the eastern Baltic Sea

NASA Astrophysics Data System (ADS)

Pindsoo, Katri; Soomere, Tarmo

2016-04-01

The water level time series and particularly temporal variations in water level extremes usually do not follow any simple rule. Still, the analysis of linear trends in extreme values of surge levels is a convenient tool to obtain a first approximation of the future projections of the risks associated with coastal floodings. We demonstrate how this tool can be used to extract essential information about concealed changes in the forcing factors of seas and oceans. A specific feature of the Baltic Sea is that sequences of even moderate storms may raise the average sea level by almost 1 m for a few weeks. Such events occur once in a few years. They substantially contribute to the extreme water levels in the eastern Baltic Sea: the most devastating coastal floodings occur when a strong storm from unfortunate direction arrives during such an event. We focus on the separation of subtidal (weekly-scale) processes from those which are caused by a single storm and on establishing how much these two kinds of events have contributed to the increase in the extreme water levels in the eastern Baltic Sea. The analysis relies on numerically reconstructed sea levels produced by the RCO (Rossby Center, Swedish Meteorological and Hydrological Institute) ocean model for 1961-2005. The reaction of sea surface to single storm events is isolated from the local water level time series using a running average over a fixed interval. The distribution of average water levels has an almost Gaussian shape for averaging lengths from a few days to a few months. The residual (total water level minus the average) can be interpreted as a proxy of the local storm surges. Interestingly, for the 8-day average this residual almost exactly follows the exponential distribution. Therefore, for this averaging length the heights of local storm surges reflect an underlying Poisson process. This feature is universal for the entire eastern Baltic Sea coast. The slopes of the exponential distribution for low and high water levels are different, vary markedly along the coast and provide a useful quantification of the vulnerability of single coastal segments with respect to coastal flooding. The formal linear trends in the extreme values of these water level components exhibit radically different spatial variations. The slopes of the trends in the weekly average are almost constant (~4 cm/decade for 8-day running average) along the entire eastern Baltic Sea coast. This first of all indicates that the duration of storm sequences has increased. The trends for maxima of local storm surge heights represent almost the entire spatial variability in the water level extremes. Their slopes are almost zero at the open Baltic Proper coasts of the Western Estonian archipelago. Therefore, an increase in wind speed in strong storms is unlikely in this area. In contrast, the slopes in question reach 5-7 cm/decade in the eastern Gulf of Finland and Gulf of Riga. This feature suggests that wind direction in strongest storms may have rotated in the northern Baltic Sea.

A method for Removing Surface Contamination on Ultra-pure Copper Spectrometer Components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoppe, Eric W.; Seifert, Allen; Aalseth, Craig E.

Spectrometers for the lowest-level radiometric measurements require materials of extreme radiopurity. Measurements of rare nuclear decays, e.g. neutrinoless double-beta decay, can require construction and shielding materials with bulk radiopurity reaching one micro-Becquerel per kilogram or less. When such extreme material purity is achieved, surface contamination, particularly solid daughters in the natural radon decay chains, can become the limiting background. High-purity copper is an important material for ultra-low-background spectrometers and thus is the focus of this work. A method for removing surface contamination at very low levels without attacking the bulk material is described. An assay method using a low-background proportionalmore » counter made of the material under examination is employed, and the resulting preliminary result of achievable surface contamination levels is presented.« less

Effectiveness of community psychosocial and pharmacological treatments for alcohol use disorder: A national observational cohort study in England.

PubMed

Peacock, Amy; Eastwood, Brian; Jones, Andrew; Millar, Tim; Horgan, Patrick; Knight, Jonathan; Randhawa, Kulvir; White, Martin; Marsden, John

2018-05-01

This was a national English observational cohort study using administrative data to estimate the effectiveness of community pharmacological and psychosocial treatment for alcohol use disorder (AUD). All adults commencing AUD treatment in the community reported to the National Drug Treatment Monitoring System (April 1 2014-March 31 2015; N = 52,499). Past 28-day admission drinking pattern included drinks per drinking day (DDD): 0 ('Abstinent'), 1-15 ('Low-High'), 16-30 ('High-Extreme') and over 30 DDD ('Extreme'). The primary outcome was successful completion of treatment within 12 months of commencement with no re-presentation (SCNR) in the subsequent six months, analysed by multi-level, mixed effects, multivariable logistic regression. The majority reported DDD in the 'Low-High' (n = 17,698, 34%) and 'High-Extreme' (n = 21,383, 41%) range. Smaller proportions were categorised 'Extreme' (n = 7759, 15%) and 'Abstinent' (n = 5661, 11%). Three-fifths (58%) achieved SCNR. Predictors of SCNR were older age, black/minority ethnic group, employment, criminal justice system referral, and longer treatment exposure. Predictors of negative outcome were AUD treatment history, lower socio-economic status, housing problems, and 'Extreme' drinking at admission. In addition to psychosocial interventions, pharmacological interventions and recovery support increased the likelihood of SCNR. Pharmacological treatment was only beneficial for the 'Low-High' groups with recovery support. Over half of all patients admitted for community AUD treatment in England are reported to successfully complete treatment within 12 months and are not re-admitted for further treatment in the following 6 months. Study findings underscore efforts to tailor AUD treatment to the severity of alcohol consumption and using recovery support. Copyright © 2018 Elsevier B.V. All rights reserved.

Application of short-data methods on extreme surge levels

NASA Astrophysics Data System (ADS)

Feng, X.

2014-12-01

Tropical cyclone-induced storm surges are among the most destructive natural hazards that impact the United States. Unfortunately for academic research, the available time series for extreme surge analysis are very short. The limited data introduces uncertainty and affects the accuracy of statistical analyses of extreme surge levels. This study deals with techniques applicable to data sets less than 20 years, including simulation modelling and methods based on the parameters of the parent distribution. The verified water levels from water gauges spread along the Southwest and Southeast Florida Coast, as well as the Florida Keys, are used in this study. Methods to calculate extreme storm surges are described and reviewed, including 'classical' methods based on the generalized extreme value (GEV) distribution and the generalized Pareto distribution (GPD), and approaches designed specifically to deal with short data sets. Incorporating global-warming influence, the statistical analysis reveals enhanced extreme surge magnitudes and frequencies during warm years, while reduced levels of extreme surge activity are observed in the same study domain during cold years. Furthermore, a non-stationary GEV distribution is applied to predict the extreme surge levels with warming sea surface temperatures. The non-stationary GEV distribution indicates that with 1 Celsius degree warming in sea surface temperature from the baseline climate, the 100-year return surge level in Southwest and Southeast Florida will increase by up to 40 centimeters. The considered statistical approaches for extreme surge estimation based on short data sets will be valuable to coastal stakeholders, including urban planners, emergency managers, and the hurricane and storm surge forecasting and warning system.

Intra-arterial Ultra-low-Dose CT Angiography of Lower Extremity in Diabetic Patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Özgen, Ali, E-mail: draliozgen@hotmail.com; Sanioğlu, Soner; Bingöl, Uğur Anıl

2016-08-15

PurposeTo image lower extremity arteries by CT angiography using a very low-dose intra-arterial contrast medium in patients with high risk of developing contrast-induced nephropathy (CIN).Materials and MethodsThree cases with long-standing diabetes mellitus and signs of lower extremity atherosclerotic disease were evaluated by CT angiography using 0.1 ml/kg of the body weight of contrast medium given via 10-cm-long 4F introducer by puncturing the CFA. Images were evaluated by an interventional radiologist and a cardiovascular surgeon. Density values of the lower extremity arteries were also calculated. Findings in two cases were compared with digital subtraction angiography images performed for percutaneous revascularization. Blood creatininemore » levels were followed for possible CIN.ResultsIntra-arterial CT angiography images were considered diagnostic in all patients and optimal in one patient. No patient developed CIN after intra-arterial CT angiography, while one patient developed CIN after percutaneous intervention.ConclusionIntra-arterial CT angiography of lower extremity might be performed in selected patients with high risk of developing CIN. Our limited experience suggests that as low as of 0.1 ml/kg of the body weight of contrast medium may result in adequate diagnostic imaging.« less

Short physical performance battery for middle-aged and older adult cardiovascular disease patients: implication for strength tests and lower extremity morphological evaluation.

PubMed

Yasuda, Tomohiro; Fukumura, Kazuya; Nakajima, Toshiaki

2017-04-01

[Purpose] To examine if the SPPB is higher with healthy subjects than outpatients, which was higher than inpatients and if the SPPB can be validated assessment tool for strength tests and lower extremity morphological evaluation in cardiovascular disease patients. [Subjects and Methods] Twenty-four middle aged and older adults with cardiovascular disease were recruited from inpatient and outpatient facilities and assigned to separate experimental groups. Twelve age-matched healthy volunteers were assigned to a control group. SPPB test was used to assess balance and functional motilities. The test outcomes were compared with level of care (inpatient vs. outpatient), physical characteristics, strength and lower extremity morphology. [Results] Total SPPB scores, strength tests (knee extensor muscle strength), and lower extremity morphological evaluation (muscle thickness of anterior and posterior mid-thigh and posterior lower-leg) were greater in healthy subjects and outpatients groups compared with inpatients. To predict total Short Physical Performance Battery scores, the predicted knee extension and anterior mid-thigh muscle thickness were calculated. [Conclusion] The SPPB is an effective tool as the strength tests and lower extremity morphological evaluation for middle-aged and older adult cardiovascular disease patients. Notably, high knee extensor muscle strength and quadriceps femoris muscle thickness are positively associated with high SPPB scores.

Effect of elevation on extreme precipitation of short durations: evidences of orographic signature on the parameters of Depth-Duration-Frequency curves

NASA Astrophysics Data System (ADS)

Avanzi, Francesco; De Michele, Carlo; Gabriele, Salvatore; Ghezzi, Antonio; Rosso, Renzo

2015-04-01

Here, we show how atmospheric circulation and topography rule the variability of depth-duration-frequency (DDF) curves parameters, and we discuss how this variability has physical implications on the formation of extreme precipitations at high elevations. A DDF is a curve ruling the value of the maximum annual precipitation H as a function of duration D and the level of probability F. We consider around 1500 stations over the Italian territory, with at least 20 years of data of maximum annual precipitation depth at different durations. We estimated the DDF parameters at each location by using the asymptotic distribution of extreme values, i.e. the so-called Generalized Extreme Value (GEV) distribution, and considering a statistical simple scale invariance hypothesis. Consequently, a DDF curve depends on five different parameters. A first set relates H with the duration (namely, the mean value of annual maximum precipitation depth for unit duration and the scaling exponent), while a second set links H to F (namely, a scale, position and shape parameter). The value of the shape parameter has consequences on the type of random variable (unbounded, upper or lower bounded). This extensive analysis shows that the variability of the mean value of annual maximum precipitation depth for unit duration obeys to the coupled effect of topography and modal direction of moisture flux during extreme events. Median values of this parameter decrease with elevation. We called this phenomenon "reverse orographic effect" on extreme precipitation of short durations, since it is in contrast with general knowledge about the orographic effect on mean precipitation. Moreover, the scaling exponent is mainly driven by topography alone (with increasing values of this parameter at increasing elevations). Therefore, the quantiles of H(D,F) at durations greater than unit turn to be more variable at high elevations than at low elevations. Additionally, the analysis of the variability of the shape parameter with elevation shows that extreme events at high elevations appear to be distributed according to an upper bounded probability distribution. These evidences could be a characteristic sign of the formation of extreme precipitation events at high elevations.

Roles of prices, poverty, and health in Medicare and private spending in Texas.

PubMed

White, Chapin; Taychakhoonavudh, Suthira; Parikh, Rohan; Franzini, Luisa

2015-05-01

To investigate the roles of prices, poverty, and health in divergences between Medicare and private spending in Texas. Retrospective observational design using 2011 Blue Cross Blue Shield of Texas claims data and publicly available Medicare data. We measured market-level spending per enrollee among the privately insured. Variation in Medicare and private spending per person are decomposed into prices and quantities, and their associations with poverty are measured. Markets are divided into 4 groups and are compared based on the ratio of Medicare to private spending: "high-private," "proportional," "high-Medicare," and "extremely high-Medicare." Among the privately insured, poverty appears to have large spillover effects; it is strongly associated with lower prices, quantities, and spending. Among Medicare beneficiaries, health status is a key driver of spending variation. The 2 markets with extremely high Medicare-to-private spending ratios (Harlingen and McAllen) are predominantly Hispanic communities with markedly higher rates of poverty and lack of insurance and also extremely low physician supply. The markets with relatively high private spending stand out for having good health-system performance and health outcomes, and higher than average hospital prices. Variation in private spending appears to reflect the ability of the local population to pay for healthcare, whereas variation in Medicare is more heavily driven by health status, and presumably, by clinical need. These findings highlight the inadvisability of using Medicare spending as a proxy for systemwide spending, and the need for comprehensive market-level spending data that allow comparisons among populations with different sources of insurance coverage.

Impacts of future changes in weather condition on U.S. transportation

NASA Astrophysics Data System (ADS)

Ashfaq, M.; Pagan, B. R.; Bonds, B. W.; Rastogi, D.

2016-12-01

High-resolution near-term climate projections suggest an intensification of the regional hydrological cycle over the U.S., leading to stronger and more frequent precipitation events. Increase in precipitation extremes is driven by both warm season convection driven rainstorms and frontal based cold season snowstorms. Results also indicate that future warming is driven more by hot extremes, as decrease in cold extremes is three times less than increase in hot extremes. While projected changes may likely impact the transportation system across the U.S., accurate estimation of such impacts requires knowledge of changes in precipitation types (rain, snow, ice, freezing rain). Here we apply four commonly used precipitation typing algorithms to determine different types of precipitation in an 11-memebr high-resolution (18 km) climate projections dataset that covers 40 years (1966-2005) in the baseline and 40 years (2011-2050) in the future period under Representative Concentration Pathway 8.5. The results are compared with the NARR-based precipitation classification in the historical period at the county level. Documented weather related county level fatal crash data for the CONUS and non-fatal crash data for selected states in the eastern half of the U.S. is compiled to develop the historical baseline for the impact of weather conditions on transportation. Further analysis is carried out to understand the ability of an ensemble of high-resolution simulations to produce different precipitation types in the baseline period, potential changes in the occurrence of each type of weather condition in the future period and that how such changes may impact road conditions, vehicle crashes and human fatalities. Additional analysis will also be explored to understand the impact of changes in winter weather conditions on the cost associated with road maintenance.

Low Biotoxicity of Mars Analog Soils Suggests that the Surface of Mars May be Habitable for Terrestrial Microorganisms

NASA Technical Reports Server (NTRS)

Schuerger, A. C.; Ming, Douglas W.; Golden, D. C.

2012-01-01

Recent studies on the interactive effects of hypobaria, low temperatures, and CO2-enriched anoxic atmospheres on the growth of 37 species of mesophilic bacteria identified 14 potential biocidal agents that might affect microbial survival and growth on the martian surface. Biocidal or inhibitory factors include (not in priority): (1) solar UV irradiation, (2) low pressure, (3) extreme desiccating conditions, (4) extreme diurnal temperature fluctuations, (5) solar particle events, (6) galactic cosmic rays, (7) UV-glow discharge from blowing dust, (8) solar UV-induced volatile oxidants [e.g., O2(-), O(-), H2O2, O3], (9) globally distributed oxidizing soils, (10) extremely high salts levels [e.g., MgCl2, NaCl, FeSO4, and MgSO4] in surficial soils at some sites on Mars, (11) high concentrations of heavy metals in martian soils, (12) likely acidic conditions in martian fines, (13) high CO2 concentrations in the global atmosphere, and (14) perchlorate-rich soils. Despite these extreme conditions several studies have demonstrated that dormant spores or vegetative cells of terrestrial microorganisms can survive simulated martian conditions as long as they are protected from UV irradiation. What has not been explored in depth are the effects of potential biotoxic geochemical components of the martian regolith on the survival and growth of microorganisms. The primary objectives of the research included: (1) prepare and characterize Mars analog soils amended with potential biotoxic levels of sulfates, salts, acidifying minerals, etc.; and (2) use the simulants to conduct biotoxicity assays to determine if terrestrial microorganisms from spacecraft can survive direct exposure to the analog soils.

Bacterial and archaeal resistance to ionizing radiation

NASA Astrophysics Data System (ADS)

Confalonieri, F.; Sommer, S.

2011-01-01

Organisms living in extreme environments must cope with large fluctuations of temperature, high levels of radiation and/or desiccation, conditions that can induce DNA damage ranging from base modifications to DNA double-strand breaks. The bacterium Deinococcus radiodurans is known for its resistance to extremely high doses of ionizing radiation and for its ability to reconstruct a functional genome from hundreds of radiation-induced chromosomal fragments. Recently, extreme ionizing radiation resistance was also generated by directed evolution of an apparently radiation-sensitive bacterial species, Escherichia coli. Radioresistant organisms are not only found among the Eubacteria but also among the Archaea that represent the third kingdom of life. They present a set of particular features that differentiate them from the Eubacteria and eukaryotes. Moreover, Archaea are often isolated from extreme environments where they live under severe conditions of temperature, pressure, pH, salts or toxic compounds that are lethal for the large majority of living organisms. Thus, Archaea offer the opportunity to understand how cells are able to cope with such harsh conditions. Among them, the halophilic archaeon Halobacterium sp and several Pyrococcus or Thermococcus species, such as Thermococcus gammatolerans, were also shown to display high level of radiation resistance. The dispersion, in the phylogenetic tree, of radioresistant prokaryotes suggests that they have independently acquired radioresistance. Different strategies were selected during evolution including several mechanisms of radiation byproduct detoxification and subtle cellular metabolism modifications to help cells recover from radiation-induced injuries, protection of proteins against oxidation, an efficient DNA repair tool box, an original pathway of DNA double-strand break repair, a condensed nucleoid that may prevent the dispersion of the DNA fragments and specific radiation-induced proteins involved in radioresistance. Here, we compare mechanisms and discuss hypotheses suggested to contribute to radioresistance in several Archaea and Eubacteria.

Ablation centration after active eye tracker-assisted LASIK and comparison of flying-spot and broad-beam laser.

PubMed

Lin, Jane-Ming; Chen, Wen-Lu; Chiang, Chun-Chi; Tsai, Yi-Yu

2008-04-01

To evaluate ablation centration of flying-spot LASIK, investigate the effect of patient- and surgeon-related factors on centration, and compare flying-spot and broad-beam laser results. This retrospective study comprised 173 eyes of 94 patients who underwent LASIK with the Alcon LADARVision4000 with an active eye-tracking system. The effective tracking rate of the system is 100 Hz. The amount of decentration was analyzed by corneal topography. Patient- (low, high, and extreme myopia; effect of learning) and surgeon-related (learning curve) factors influencing centration were identified. Centration was compared to the SCHWIND Multiscan broad-beam laser with a 50-Hz tracker from a previous study. Mean decentration was 0.36+/-0.18 mm (range: 0 to 0.9 mm). Centration did not differ in low, high, and extreme myopia or in patients' first and second eyes. There were no significant differences in centration between the first 50 LASIK procedures and the last 50 procedures. Comparing flying-spot and broad-beam laser results, there were no differences in centration in low myopia. However, the LADARVision4000 yielded better centration results in high and extreme myopia. The Alcon LADARVision4000 active eye tracking system provides good centration for all levels of myopic correction and better centration than the Schwind broad-beam Multiscan in eyes with high and extreme myopia.

Estimating maximum instantaneous distortion from inlet total pressure rms and PSD measurements. [Root Mean Square and Power Spectral Density methods

NASA Technical Reports Server (NTRS)

Melick, H. C., Jr.; Ybarra, A. H.; Bencze, D. P.

1975-01-01

An inexpensive method is developed to determine the extreme values of instantaneous inlet distortion. This method also provides insight into the basic mechanics of unsteady inlet flow and the associated engine reaction. The analysis is based on fundamental fluid dynamics and statistical methods to provide an understanding of the turbulent inlet flow and quantitatively relate the rms level and power spectral density (PSD) function of the measured time variant total pressure fluctuations to the strength and size of the low pressure regions. The most probable extreme value of the instantaneous distortion is then synthesized from this information in conjunction with the steady state distortion. Results of the analysis show the extreme values to be dependent upon the steady state distortion, the measured turbulence rms level and PSD function, the time on point, and the engine response characteristics. Analytical projections of instantaneous distortion are presented and compared with data obtained by a conventional, highly time correlated, 40 probe instantaneous pressure measurement system.

Invited Article: Visualisation of extreme value events in optical communications

NASA Astrophysics Data System (ADS)

Derevyanko, Stanislav; Redyuk, Alexey; Vergeles, Sergey; Turitsyn, Sergei

2018-06-01

Fluctuations of a temporal signal propagating along long-haul transoceanic scale fiber links can be visualised in the spatio-temporal domain drawing visual analogy with ocean waves. Substantial overlapping of information symbols or use of multi-frequency signals leads to strong statistical deviations of local peak power from an average signal power level. We consider long-haul optical communication systems from this unusual angle, treating them as physical systems with a huge number of random statistical events, including extreme value fluctuations that potentially might affect the quality of data transmission. We apply the well-established concepts of adaptive wavefront shaping used in imaging through turbid medium to detect the detrimental phase modulated sequences in optical communications that can cause extreme power outages (rare optical waves of ultra-high amplitude) during propagation down the ultra-long fiber line. We illustrate the concept by a theoretical analysis of rare events of high-intensity fluctuations—optical freak waves, taking as an example an increasingly popular optical frequency division multiplexing data format where the problem of high peak to average power ratio is the most acute. We also show how such short living extreme value spikes in the optical data streams are affected by nonlinearity and demonstrate the negative impact of such events on the system performance.

Examining global extreme sea level variations on the coast from in-situ and remote observations

NASA Astrophysics Data System (ADS)

Menendez, Melisa; Benkler, Anna S.

2017-04-01

The estimation of extreme water level values on the coast is a requirement for a wide range of engineering and coastal management applications. In addition, climate variations of extreme sea levels on the coastal area result from a complex interacting of oceanic, atmospheric and terrestrial processes across a wide range of spatial and temporal scales. In this study, variations of extreme sea level return values are investigated from two available sources of information: in-situ tide-gauge records and satellite altimetry data. Long time series of sea level from tide-gauge records are the most valuable observations since they directly measure water level in a specific coastal location. They have however a number of sources of in-homogeneities that may affect the climate description of extremes when this data source is used. Among others, the presence of gaps, historical time in-homogeneities and jumps in the mean sea level signal are factors that can provide uncertainty in the characterization of the extreme sea level behaviour. Moreover, long records from tide-gauges are sparse and there are many coastal areas worldwide without in-situ available information. On the other hand, with the accumulating altimeter records of several satellite missions from the 1990s, approaching 25 recorded years at the time of writing, it is becoming possible the analysis of extreme sea level events from this data source. Aside the well-known issue of altimeter measurements very close to the coast (mainly due to corruption by land, wet troposphere path delay errors and local tide effects on the coastal area), there are other aspects that have to be considered when sea surface height values estimated from satellite are going to be used in a statistical extreme model, such as the use of a multi-mission product to get long observed periods and the selection of the maxima sample, since altimeter observations do not provide values uniform in time and space. Here, we have compared the extreme values of 'still water level' and 'non-tidal-residual' of in-situ records from the GESLA2 dataset (Woodworth et al. 2016) against the novel coastal altimetry datasets (Cipollini et al. 2016). Seasonal patterns, inter-annual variability and long-term trends are analyzed. Then, a time-dependent extreme model (Menendez et al. 2009) is applied to characterize extreme sea level return values and their variability on the coastal area around the world.

Tightly Coupled Mechanistic Study of Materials in the Extreme Space Environment

DTIC Science & Technology

2016-10-11

to examine spacecraft contamination issues from the perspective of non- equilibrium gas dynamics (Levin), material response at the atomistic level...Space Environment Group has worked to examine spacecraft contamination issues from the perspective of non- equilibrium gas dynamics (Levin...material response at the atomistic level (Rajan), high fidelity gas -surface chemistry models (van Duin), and experiments to characterize and test

Underwater noise reduction of marine pile driving using a double pile.

DOT National Transportation Integrated Search

2015-12-01

Impact pile driving of steel piles in marine environments produces extremely high sound levels in the water. : It has been shown that current pile driving noise attenuation techniques, such as bubble curtains and : cofferdams, provide limited noise r...

Association between foot type and lower extremity injuries: systematic literature review with meta-analysis.

PubMed

Tong, Jasper W K; Kong, Pui W

2013-10-01

Systematic literature review with meta-analysis. To investigate the association between nonneutral foot types (high arch and flatfoot) and lower extremity and low back injuries, and to identify the most appropriate methods to use for foot classification. A search of 5 electronic databases (PubMed, Embase, CINAHL, SPORTDiscus, and ProQuest Dissertations and Theses), Google Scholar, and the reference lists of included studies was conducted to identify relevant articles. The review included comparative cross-sectional, case-control, and prospective studies that reported qualitative/quantitative associations between foot types and lower extremity and back injuries. Quality of the selected studies was evaluated, and data synthesis for the level of association between foot types and injuries was conducted. A random-effects model was used to pool odds ratio (OR) and standardized mean difference (SMD) results for meta-analysis. Twenty-nine studies were included for meta-analysis. A significant association between nonneutral foot types and lower extremity injuries was determined (OR = 1.23; 95% confidence interval [CI]: 1.11, 1.37; P<.001). Foot posture index (OR = 2.58; 95% CI: 1.33, 5.02; P<.01) and visual/physical examination (OR = 1.17; 95% CI: 1.06, 1.28; P<.01) were 2 assessment methods using distinct foot-type categories that showed a significant association with lower extremity injuries. For foot-assessment methods using a continuous scale, measurements of lateral calcaneal pitch angle (SMD, 1.92; 95% CI: 1.44, 2.39; P<.00001), lateral talocalcaneal angle (SMD, 1.36; 95% CI: 0.93, 1.80; P<.00001), and navicular height (SMD, 0.34; 95% CI: 0.16, 0.52; P<.001) showed significant effect sizes in identifying high-arch foot, whereas the navicular drop test (SMD, 0.45; 95% CI: 0.03, 0.87; P<.05) and relaxed calcaneal stance position (SMD, 0.49; 95% CI: 0.01, 0.97; P<.05) displayed significant effect sizes in identifying flatfoot. Subgroup analyses revealed no significant associations for children with flatfoot, cross-sectional studies, or prospective studies on high arch. High-arch and flatfoot foot types are associated with lower extremity injuries, but the strength of this relationship is low. Although the foot posture index and visual/physical examination showed significance, they are qualitative measures. Radiographic and navicular height measurements can delineate high-arch foot effectively, with only anthropometric measures accurately classifying flatfoot. Prognosis, level 2a.

An Examination of Transformational Leadership Practices by Public School Principals in Monmouth County, New Jersey

ERIC Educational Resources Information Center

Aldarelli, Edward

2017-01-01

The demands of high-stakes testing, tenure reform, and teacher accountability have dominated the landscape of education for almost two decades. The expectations placed on public schools require leadership that supports and motivates teachers to perform at extremely high levels. Public schools therefore must fill their institutions with principals…

Extreme weather exposure identification for road networks - a comparative assessment of statistical methods

NASA Astrophysics Data System (ADS)

Schlögl, Matthias; Laaha, Gregor

2017-04-01

The assessment of road infrastructure exposure to extreme weather events is of major importance for scientists and practitioners alike. In this study, we compare the different extreme value approaches and fitting methods with respect to their value for assessing the exposure of transport networks to extreme precipitation and temperature impacts. Based on an Austrian data set from 25 meteorological stations representing diverse meteorological conditions, we assess the added value of partial duration series (PDS) over the standardly used annual maxima series (AMS) in order to give recommendations for performing extreme value statistics of meteorological hazards. Results show the merits of the robust L-moment estimation, which yielded better results than maximum likelihood estimation in 62 % of all cases. At the same time, results question the general assumption of the threshold excess approach (employing PDS) being superior to the block maxima approach (employing AMS) due to information gain. For low return periods (non-extreme events) the PDS approach tends to overestimate return levels as compared to the AMS approach, whereas an opposite behavior was found for high return levels (extreme events). In extreme cases, an inappropriate threshold was shown to lead to considerable biases that may outperform the possible gain of information from including additional extreme events by far. This effect was visible from neither the square-root criterion nor standardly used graphical diagnosis (mean residual life plot) but rather from a direct comparison of AMS and PDS in combined quantile plots. We therefore recommend performing AMS and PDS approaches simultaneously in order to select the best-suited approach. This will make the analyses more robust, not only in cases where threshold selection and dependency introduces biases to the PDS approach but also in cases where the AMS contains non-extreme events that may introduce similar biases. For assessing the performance of extreme events we recommend the use of conditional performance measures that focus on rare events only in addition to standardly used unconditional indicators. The findings of the study directly address road and traffic management but can be transferred to a range of other environmental variables including meteorological and hydrological quantities.

LEVELS OF EXTREMELY LOW-FREQUENCY ELECTRIC AND MAGNETIC FIELDS FROM OVERHEAD POWER LINES IN THE OUTDOOR ENVIRONMENT OF RAMALLAH CITY-PALESTINE.

PubMed

Abuasbi, Falastine; Lahham, Adnan; Abdel-Raziq, Issam Rashid

2018-05-01

In this study, levels of extremely low-frequency electric and magnetic fields originated from overhead power lines were investigated in the outdoor environment in Ramallah city, Palestine. Spot measurements were applied to record fields intensities over 6-min period. The Spectrum Analyzer NF-5035 was used to perform measurements at 1 m above ground level and directly underneath 40 randomly selected power lines distributed fairly within the city. Levels of electric fields varied depending on the line's category (power line, transformer or distributor), a minimum mean electric field of 3.9 V/m was found under a distributor line, and a maximum of 769.4 V/m under a high-voltage power line (66 kV). However, results of electric fields showed a log-normal distribution with the geometric mean and the geometric standard deviation of 35.9 and 2.8 V/m, respectively. Magnetic fields measured at power lines, on contrast, were not log-normally distributed; the minimum and maximum mean magnetic fields under power lines were 0.89 and 3.5 μT, respectively. As a result, none of the measured fields exceeded the ICNIRP's guidelines recommended for general public exposures to extremely low-frequency fields.

Determining return water levels at ungauged coastal sites: a case study for northern Germany

NASA Astrophysics Data System (ADS)

Arns, Arne; Wahl, Thomas; Haigh, Ivan D.; Jensen, Jürgen

2015-04-01

We estimate return periods and levels of extreme still water levels for the highly vulnerable and historically and culturally important small marsh islands known as the Halligen, located in the Wadden Sea offshore of the coast of northern Germany. This is a challenging task as only few water level records are available for this region, and they are currently too short to apply traditional extreme value analysis methods. Therefore, we use the Regional Frequency Analysis (RFA) approach. This originates from hydrology but has been used before in several coastal studies and is also currently applied by the local federal administration responsible for coastal protection in the study area. The RFA enables us to indirectly estimate return levels by transferring hydrological information from gauged to related ungauged sites. Our analyses highlight that this methodology has some drawbacks and may over- or underestimate return levels compared to direct analyses using station data. To overcome these issues, we present an alternative approach, combining numerical and statistical models. First, we produced a numerical multidecadal model hindcast of water levels for the entire North Sea. Predicted water levels from the hindcast are bias corrected using the information from the available tide gauge records. Hence, the simulated water levels agree well with the measured water levels at gauged sites. The bias correction is then interpolated spatially to obtain correction functions for the simulated water levels at each coastal and island model grid point in the study area. Using a recommended procedure to conduct extreme value analyses from a companion study, return water levels suitable for coastal infrastructure design are estimated continuously along the entire coastline of the study area, including the offshore islands. A similar methodology can be applied in other regions of the world where tide gauge observations are sparse.

Regional Risk Assessment for the analysis of the risks related to storm surge extreme events in the coastal area of the North Adriatic Sea.

NASA Astrophysics Data System (ADS)

Rizzi, Jonathan; Torresan, Silvia; Gallina, Valentina; Critto, Andrea; Marcomini, Antonio

2013-04-01

Europe's coast faces a variety of climate change threats from extreme high tides, storm surges and rising sea levels. In particular, it is very likely that mean sea level rise will contribute to upward trends in extreme coastal high water levels, thus posing higher risks to coastal locations currently experiencing coastal erosion and inundation processes. In 2007 the European Commission approved the Flood Directive (2007/60/EC), which has the main purpose to establish a framework for the assessment and management of flood risks for inland and coastal areas, thus reducing the adverse consequences for human health, the environment, cultural heritage and economic activities. Improvements in scientific understanding are thus needed to inform decision-making about the best strategies for mitigating and managing storm surge risks in coastal areas. The CLIMDAT project is aimed at improving the understanding of the risks related to extreme storm surge events in the coastal area of the North Adriatic Sea (Italy), considering potential climate change scenarios. The project implements a Regional Risk Assessment (RRA) methodology developed in the FP7 KULTURisk project for the assessment of physical/environmental impacts posed by flood hazards and employs the DEcision support SYstem for Coastal climate change impact assessment (DESYCO) for the application of the methodology to the case study area. The proposed RRA methodology is aimed at the identification and prioritization of targets and areas at risk from water-related natural hazards in the considered region at the meso-scale. To this aim, it integrates information about extreme storm surges with bio-geophysical and socio-economic information (e.g. vegetation cover, slope, soil type, population density) of the analyzed receptors (i.e. people, economic activities, cultural heritages, natural and semi-natural systems). Extreme storm surge hazard scenarios are defined using tide gauge time series coming from 28 tide gauge stations located in the North Adriatic coastal areas from 1989 to 2011. These data, together with the sea-level rise scenarios for the considered future timeframe, represent the input for the application of the Joint Probability method (Pugh and Vassie, 1979), which allows the evaluation of the maximum height of extreme storm surge events with different return period and the number of extreme events per year. The methodology uses Geographic Information Systems to manage, process, analyse, and visualize data and employs Multi-Criteria Decision Analysis to integrate stakeholders preferences and experts judgments into the analysis in order to obtain a total risk index in the considered region. The final outputs are represented by GIS-based risk maps which allow the communication of the potential consequences of extreme storm surge to decision makers and stakeholders. Moreover, they can support the establishment of relative priorities for intervention through the identification of suitable areas for human settlements, infrastructures and economic activities. Finally the produced output can represent a basis for definition of storm surge hazard and storm surge risk management plans according to the Floods Directive. The preliminary results of the RRA application in the CLIMDAT project will be here presented and discussed.

Extreme risk assessment based on normalized historic loss data

NASA Astrophysics Data System (ADS)

Eichner, Jan

2017-04-01

Natural hazard risk assessment and risk management focuses on the expected loss magnitudes of rare and extreme events. Such large-scale loss events typically comprise all aspects of compound events and accumulate losses from multiple sectors (including knock-on effects). Utilizing Munich Re's NatCatSERVICE direct economic loss data, we beriefly recap a novel methodology of peril-specific loss data normalization which improves the stationarity properties of highly non-stationary historic loss data (due to socio-economic growth of assets prone to destructive forces), and perform extreme value analysis (peaks-over-threshold method) to come up with return level estimates of e.g. 100-yr loss event scenarios for various types of perils, globally or per continent, and discuss uncertainty in the results.

USACE Extreme Sea levels

DTIC Science & Technology

2014-03-14

with expected changes due to climate change. (tropicals and extra-tropicals) Ivan provided some good information on work being done on tropical...Pattiaratchi, C., Jensen, J., 2013. Estimating extreme water level probabilities: a comparison of the direct methods and recommendations for best practise ...sites: site-by-site analyses. Proudman Oceanographic Laboratory , Internal Document, No. 65, 229pp. Dixon, M.J., Tawn, J.A. (1995) Extreme sea-levels

Stress fracture of ulna due to excessive push-ups.

PubMed

Meena, Sanjay; Rastogi, Devarshi; Solanki, Bipin; Chowdhury, Buddhadev

2014-01-01

Stress fractures are most common in the weight-bearing bones of the lower extremities and spine, but are rarely found in non-weight-bearing bones of the body. Stress fracture of the ulna is extremely rare. We report a case of complete stress fracture of ulna caused due to excessive push ups in a young athlete. Conservative management was successful in healing of fracture and returning this patient back to his previous activity level. Physician should have high index of suspicion, whenever they encounter a young athlete complaining of forearm pain.

[Multi-temporal scale analysis of impacts of extreme high temperature on net carbon uptake in subtropical coniferous plantation.

PubMed

Zhang, Mi; Wen, Xue Fa; Zhang, Lei Ming; Wang, Hui Min; Guo, Yi Wen; Yu, Gui Rui

2018-02-01

Extreme high temperature is one of important extreme weathers that impact forest ecosystem carbon cycle. In this study, applying CO 2 flux and routine meteorological data measured during 2003-2012, we examined the impacts of extreme high temperature and extreme high temperature event on net carbon uptake of subtropical coniferous plantation in Qianyanzhou. Combining with wavelet analysis, we analyzed environmental controls on net carbon uptake at different temporal scales, when the extreme high temperature and extreme high temperature event happened. The results showed that mean daily cumulative NEE decreased by 51% in the days with daily maximum air temperature range between 35 ℃ and 40 ℃, compared with that in the days with the range between 30 ℃ and 34 ℃. The effects of the extreme high temperature and extreme high temperature event on monthly NEE and annual NEE related to the strength and duration of extreme high tempe-rature event. In 2003, when strong extreme high temperature event happened, the sum of monthly cumulative NEE in July and August was only -11.64 g C·m -2 ·(2 month) -1 . The value decreased by 90%, compared with multi-year average value. At the same time, the relative variation of annual NEE reached -6.7%. In July and August, when the extreme high temperature and extreme high temperature event occurred, air temperature (T a ) and vapor press deficit (VPD) were the dominant controller for the daily variation of NEE. The coherency between NEE T a and NEE VPD was 0.97 and 0.95, respectively. At 8-, 16-, and 32-day periods, T a , VPD, soil water content at 5 cm depth (SWC), and precipitation (P) controlled NEE. The coherency between NEE SWC and NEE P was higher than 0.8 at monthly scale. The results indicated that atmospheric water deficit impacted NEE at short temporal scale, when the extreme high temperature and extreme high temperature event occurred, both of atmospheric water deficit and soil drought stress impacted NEE at long temporal scales in this ecosystem.

Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis.

PubMed

Asdourian, Maria S; Skolny, Melissa N; Brunelle, Cheryl; Seward, Cara E; Salama, Laura; Taghian, Alphonse G

2016-09-01

Precautionary recommendations conveyed to survivors of cancer by health-care practitioners to reduce the risk of breast cancer-related lymphoedema are indispensable aspects of clinical care, yet remain unsubstantiated by high-level scientific evidence. By reviewing the literature, we identified 31 original research articles that examined whether lifestyle-associated risk factors (air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and skin infections-eg, cellulitis) increase the risk of breast cancer-related lymphoedema. Among the few studies that lend support to precautionary guidelines, most provide low-level (levels 3-5) or inconclusive evidence of an association between lymphoedema and these risk factors, and only four level 2 studies show a significant association. Skin infections and previous infection or inflammation on the ipsilateral arm were among the most clearly defined and well established risk factors for lymphoedema. The paucity of high-level evidence and the conflicting nature of the existing literature make it difficult to establish definitive predictive factors for breast cancer-related lymphoedema, which could be a considerable source of patient distress and anxiety. Along with further research into these risk factors, continued discussion regarding modification of the guidelines and adoption of a risk-adjusted approach is needed. Copyright © 2016 Elsevier Ltd. All rights reserved.

Diversity of extremophilic bacteria in the sediment of high-altitude lakes located in the mountain desert of Ojos del Salado volcano, Dry-Andes.

PubMed

Aszalós, Júlia Margit; Krett, Gergely; Anda, Dóra; Márialigeti, Károly; Nagy, Balázs; Borsodi, Andrea K

2016-09-01

Ojos del Salado, the highest volcano on Earth is surrounded by a special mountain desert with extreme aridity, great daily temperature range, intense solar radiation, and permafrost from 5000 meters above sea level. Several saline lakes and permafrost derived high-altitude lakes can be found in this area, often surrounded by fumaroles and hot springs. The aim of this study was to gain information about the bacterial communities inhabiting the sediment of high-altitude lakes of the Ojos del Salado region located between 3770 and 6500 m. Altogether 11 sediment samples from 4 different altitudes were examined with 16S rRNA gene based denaturing gradient gel electrophoresis and clone libraries. Members of 17 phyla or candidate divisions were detected with the dominance of Proteobacteria, Acidobacteria, Actinobacteria and Bacteroidetes. The bacterial community composition was determined mainly by the altitude of the sampling sites; nevertheless, the extreme aridity and the active volcanism had a strong influence on it. Most of the sequences showed the highest relation to bacterial species or uncultured clones from similar extreme environments.

Probing the origin of cosmic rays with extremely high energy neutrinos using the IceCube Observatory

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Abbasi, R.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Altmann, D.; Arguelles, C.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berghaus, P.; Berley, D.; Bernardini, E.; Bernhard, A.; Besson, D. Z.; Binder, G.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Brayeur, L.; Bretz, H.-P.; Brown, A. M.; Bruijn, R.; Casey, J.; Casier, M.; Chirkin, D.; Christov, A.; Christy, B.; Clark, K.; Clevermann, F.; Coenders, S.; Cohen, S.; Cowen, D. F.; Cruz Silva, A. H.; Danninger, M.; Daughhetee, J.; Davis, J. C.; Day, M.; De Clercq, C.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; Dunkman, M.; Eagan, R.; Eberhardt, B.; Eisch, J.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feintzeig, J.; Feusels, T.; Filimonov, K.; Finley, C.; Fischer-Wasels, T.; Flis, S.; Franckowiak, A.; Frantzen, K.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Golup, G.; Gonzalez, J. G.; Goodman, J. A.; Góra, D.; Grandmont, D. T.; Grant, D.; Gretskov, P.; Groh, J. C.; Groß, A.; Ha, C.; Haj Ismail, A.; Hallen, P.; Hallgren, A.; Halzen, F.; Hanson, K.; Heereman, D.; Heinen, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Homeier, A.; Hoshina, K.; Huelsnitz, W.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobi, E.; Jacobsen, J.; Jagielski, K.; Japaridze, G. S.; Jero, K.; Jlelati, O.; Kaminsky, B.; Kappes, A.; Karg, T.; Karle, A.; Kauer, M.; Kelley, J. L.; Kiryluk, J.; Kläs, J.; Klein, S. R.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Krasberg, M.; Kriesten, A.; Krings, K.; Kroll, G.; Kunnen, J.; Kurahashi, N.; Kuwabara, T.; Labare, M.; Landsman, H.; Larson, M. J.; Lesiak-Bzdak, M.; Leuermann, M.; Leute, J.; Lünemann, J.; Macías, O.; Madsen, J.; Maggi, G.; Maruyama, R.; Mase, K.; Matis, H. S.; McNally, F.; Meagher, K.; Merck, M.; Meures, T.; Miarecki, S.; Middell, E.; Milke, N.; Miller, J.; Mohrmann, L.; Montaruli, T.; Morse, R.; Nahnhauer, R.; Naumann, U.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke, A.; Odrowski, S.; Olivas, A.; Omairat, A.; O'Murchadha, A.; Paul, L.; Pepper, J. A.; Pérez de los Heros, C.; Pfendner, C.; Pieloth, D.; Pinat, E.; Posselt, J.; Price, P. B.; Przybylski, G. T.; Rädel, L.; Rameez, M.; Rawlins, K.; Redl, P.; Reimann, R.; Resconi, E.; Rhode, W.; Ribordy, M.; Richman, M.; Riedel, B.; Rodrigues, J. P.; Rott, C.; Ruhe, T.; Ruzybayev, B.; Ryckbosch, D.; Saba, S. M.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Scheriau, F.; Schmidt, T.; Schmitz, M.; Schoenen, S.; Schöneberg, S.; Schönwald, A.; Schukraft, A.; Schulte, L.; Schulz, O.; Seckel, D.; Sestayo, Y.; Seunarine, S.; Shanidze, R.; Sheremata, C.; Smith, M. W. E.; Soldin, D.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stanisha, N. A.; Stasik, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strahler, E. A.; Ström, R.; Sullivan, G. W.; Taavola, H.; Taboada, I.; Tamburro, A.; Tepe, A.; Ter-Antonyan, S.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Unger, E.; Usner, M.; Vallecorsa, S.; van Eijndhoven, N.; Van Overloop, A.; van Santen, J.; Vehring, M.; Voge, M.; Vraeghe, M.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Weaver, Ch.; Wellons, M.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Williams, D. R.; Wissing, H.; Wolf, M.; Wood, T. R.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.; Ziemann, J.; Zierke, S.; Zoll, M.

2013-12-01

We have searched for extremely high energy neutrinos using data taken with the IceCube detector between May 2010 and May 2012. Two neutrino-induced particle shower events with energies around 1 PeV were observed, as reported previously. In this work, we investigate whether these events could originate from cosmogenic neutrinos produced in the interactions of ultrahigh energy cosmic rays with ambient photons while propagating through intergalactic space. Exploiting IceCube’s large exposure for extremely high energy neutrinos and the lack of observed events above 100 PeV, we can rule out the corresponding models at more than 90% confidence level. The model-independent quasidifferential 90% C.L. upper limit, which amounts to E2ϕνe+νμ+ντ=1.2×10-7GeVcm-2s-1sr-1 at 1 EeV, provides the most stringent constraint in the energy range from 10 PeV to 10 EeV. Our observation disfavors strong cosmological evolution of the highest energy cosmic-ray sources such as the Fanaroff-Riley type II class of radio galaxies.

On the predictability of extreme events in records with linear and nonlinear long-range memory: Efficiency and noise robustness

NASA Astrophysics Data System (ADS)

Bogachev, Mikhail I.; Bunde, Armin

2011-06-01

We study the predictability of extreme events in records with linear and nonlinear long-range memory in the presence of additive white noise using two different approaches: (i) the precursory pattern recognition technique (PRT) that exploits solely the information about short-term precursors, and (ii) the return interval approach (RIA) that exploits long-range memory incorporated in the elapsed time after the last extreme event. We find that the PRT always performs better when only linear memory is present. In the presence of nonlinear memory, both methods demonstrate comparable efficiency in the absence of white noise. When additional white noise is present in the record (which is the case in most observational records), the efficiency of the PRT decreases monotonously with increasing noise level. In contrast, the RIA shows an abrupt transition between a phase of low level noise where the prediction is as good as in the absence of noise, and a phase of high level noise where the prediction becomes poor. In the phase of low and intermediate noise the RIA predicts considerably better than the PRT, which explains our recent findings in physiological and financial records.

Extreme Statistics of Storm Surges in the Baltic Sea

NASA Astrophysics Data System (ADS)

Kulikov, E. A.; Medvedev, I. P.

2017-11-01

Statistical analysis of the extreme values of the Baltic Sea level has been performed for a series of observations for 15-125 years at 13 tide gauge stations. It is shown that the empirical relation between value of extreme sea level rises or ebbs (caused by storm events) and its return period in the Baltic Sea can be well approximated by the Gumbel probability distribution. The maximum values of extreme floods/ebbs of the 100-year recurrence were observed in the Gulf of Finland and the Gulf of Riga. The two longest data series, observed in Stockholm and Vyborg over 125 years, have shown a significant deviation from the Gumbel distribution for the rarest events. Statistical analysis of the hourly sea level data series reveals some asymmetry in the variability of the Baltic Sea level. The probability of rises proved higher than that of ebbs. As for the magnitude of the 100-year recurrence surge, it considerably exceeded the magnitude of ebbs almost everywhere. This asymmetry effect can be attributed to the influence of low atmospheric pressure during storms. A statistical study of extreme values has also been applied to sea level series for Narva over the period of 1994-2000, which were simulated by the ROMS numerical model. Comparisons of the "simulated" and "observed" extreme sea level distributions show that the model reproduces quite satisfactorily extreme floods of "moderate" magnitude; however, it underestimates sea level changes for the most powerful storm surges.

Continuous 1.3-million-year record of East African hydroclimate, and implications for patterns of evolution and biodiversity

NASA Astrophysics Data System (ADS)

Lyons, Robert P.; Scholz, Christopher A.; Cohen, Andrew S.; King, John W.; Brown, Erik T.; Ivory, Sarah J.; Johnson, Thomas C.; Deino, Alan L.; Reinthal, Peter N.; McGlue, Michael M.; Blome, Margaret W.

2015-12-01

The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level variability derived from drill core data from Lake Malawi, East Africa (9-15° S). Over the Quaternary, we observe dramatic shifts in effective moisture, resulting in large-scale changes in one of the world's largest lakes and most diverse freshwater ecosystems. Results show evidence for 24 lake level drops of more than 200 m during the Late Quaternary, including 15 lowstands when water levels were more than 400 m lower than modern. A dramatic shift is observed at the Mid-Pleistocene Transition (MPT), consistent with far-field climate forcing, which separates vastly different hydroclimate regimes before and after ∼800,000 years ago. Before 800 ka, lake levels were lower, indicating a climate drier than today, and water levels changed frequently. Following the MPT high-amplitude lake level variations dominate the record. From 800 to 100 ka, a deep, often overfilled lake occupied the basin, indicating a wetter climate, but these highstands were interrupted by prolonged intervals of extreme drought. Periods of high lake level are observed during times of high eccentricity. The extreme hydroclimate variability exerted a profound influence on the Lake Malawi endemic cichlid fish species flock; the geographically extensive habitat reconfiguration provided novel ecological opportunities, enabling new populations to differentiate rapidly to distinct species.

Continuous 1.3-million-year record of East African hydroclimate, and implications for patterns of evolution and biodiversity

PubMed Central

Lyons, Robert P.; Scholz, Christopher A.; Cohen, Andrew S.; King, John W.; Brown, Erik T.; Ivory, Sarah J.; Johnson, Thomas C.; Deino, Alan L.; Reinthal, Peter N.; McGlue, Michael M.; Blome, Margaret W.

2015-01-01

The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level variability derived from drill core data from Lake Malawi, East Africa (9–15° S). Over the Quaternary, we observe dramatic shifts in effective moisture, resulting in large-scale changes in one of the world’s largest lakes and most diverse freshwater ecosystems. Results show evidence for 24 lake level drops of more than 200 m during the Late Quaternary, including 15 lowstands when water levels were more than 400 m lower than modern. A dramatic shift is observed at the Mid-Pleistocene Transition (MPT), consistent with far-field climate forcing, which separates vastly different hydroclimate regimes before and after ∼800,000 years ago. Before 800 ka, lake levels were lower, indicating a climate drier than today, and water levels changed frequently. Following the MPT high-amplitude lake level variations dominate the record. From 800 to 100 ka, a deep, often overfilled lake occupied the basin, indicating a wetter climate, but these highstands were interrupted by prolonged intervals of extreme drought. Periods of high lake level are observed during times of high eccentricity. The extreme hydroclimate variability exerted a profound influence on the Lake Malawi endemic cichlid fish species flock; the geographically extensive habitat reconfiguration provided novel ecological opportunities, enabling new populations to differentiate rapidly to distinct species. PMID:26644580

Continuous 1.3-million-year record of East African hydroclimate, and implications for patterns of evolution and biodiversity.

PubMed

Lyons, Robert P; Scholz, Christopher A; Cohen, Andrew S; King, John W; Brown, Erik T; Ivory, Sarah J; Johnson, Thomas C; Deino, Alan L; Reinthal, Peter N; McGlue, Michael M; Blome, Margaret W

2015-12-22

The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level variability derived from drill core data from Lake Malawi, East Africa (9-15° S). Over the Quaternary, we observe dramatic shifts in effective moisture, resulting in large-scale changes in one of the world's largest lakes and most diverse freshwater ecosystems. Results show evidence for 24 lake level drops of more than 200 m during the Late Quaternary, including 15 lowstands when water levels were more than 400 m lower than modern. A dramatic shift is observed at the Mid-Pleistocene Transition (MPT), consistent with far-field climate forcing, which separates vastly different hydroclimate regimes before and after ∼800,000 years ago. Before 800 ka, lake levels were lower, indicating a climate drier than today, and water levels changed frequently. Following the MPT high-amplitude lake level variations dominate the record. From 800 to 100 ka, a deep, often overfilled lake occupied the basin, indicating a wetter climate, but these highstands were interrupted by prolonged intervals of extreme drought. Periods of high lake level are observed during times of high eccentricity. The extreme hydroclimate variability exerted a profound influence on the Lake Malawi endemic cichlid fish species flock; the geographically extensive habitat reconfiguration provided novel ecological opportunities, enabling new populations to differentiate rapidly to distinct species.

Large-Scale Atmospheric Circulation Patterns Associated with Temperature Extremes as a Basis for Model Evaluation: Methodological Overview and Results

NASA Astrophysics Data System (ADS)

Loikith, P. C.; Broccoli, A. J.; Waliser, D. E.; Lintner, B. R.; Neelin, J. D.

2015-12-01

Anomalous large-scale circulation patterns often play a key role in the occurrence of temperature extremes. For example, large-scale circulation can drive horizontal temperature advection or influence local processes that lead to extreme temperatures, such as by inhibiting moderating sea breezes, promoting downslope adiabatic warming, and affecting the development of cloud cover. Additionally, large-scale circulation can influence the shape of temperature distribution tails, with important implications for the magnitude of future changes in extremes. As a result of the prominent role these patterns play in the occurrence and character of extremes, the way in which temperature extremes change in the future will be highly influenced by if and how these patterns change. It is therefore critical to identify and understand the key patterns associated with extremes at local to regional scales in the current climate and to use this foundation as a target for climate model validation. This presentation provides an overview of recent and ongoing work aimed at developing and applying novel approaches to identifying and describing the large-scale circulation patterns associated with temperature extremes in observations and using this foundation to evaluate state-of-the-art global and regional climate models. Emphasis is given to anomalies in sea level pressure and 500 hPa geopotential height over North America using several methods to identify circulation patterns, including self-organizing maps and composite analysis. Overall, evaluation results suggest that models are able to reproduce observed patterns associated with temperature extremes with reasonable fidelity in many cases. Model skill is often highest when and where synoptic-scale processes are the dominant mechanisms for extremes, and lower where sub-grid scale processes (such as those related to topography) are important. Where model skill in reproducing these patterns is high, it can be inferred that extremes are being simulated for plausible physical reasons, boosting confidence in future projections of temperature extremes. Conversely, where model skill is identified to be lower, caution should be exercised in interpreting future projections.

Climate-driven ground-level ozone extreme in the fall over the Southeast United States

PubMed Central

Wang, Yuhang

2016-01-01

Ground-level ozone is adverse to human and vegetation health. High ground-level ozone concentrations usually occur over the United States in the summer, often referred to as the ozone season. However, observed monthly mean ozone concentrations in the southeastern United States were higher in October than July in 2010. The October ozone average in 2010 reached that of July in the past three decades (1980–2010). Our analysis shows that this extreme October ozone in 2010 over the Southeast is due in part to a dry and warm weather condition, which enhances photochemical production, air stagnation, and fire emissions. Observational evidence and modeling analysis also indicate that another significant contributor is enhanced emissions of biogenic isoprene, a major ozone precursor, from water-stressed plants under a dry and warm condition. The latter finding is corroborated by recent laboratory and field studies. This climate-induced biogenic control also explains the puzzling fact that the two extremes of high October ozone both occurred in the 2000s when anthropogenic emissions were lower than the 1980s and 1990s, in contrast to the observed decreasing trend of July ozone in the region. The occurrences of a drying and warming fall, projected by climate models, will likely lead to more active photochemistry, enhanced biogenic isoprene and fire emissions, an extension of the ozone season from summer to fall, and an increase of secondary organic aerosols in the Southeast, posing challenges to regional air quality management. PMID:27551089

Climate-driven ground-level ozone extreme in the fall over the Southeast United States.

PubMed

Zhang, Yuzhong; Wang, Yuhang

2016-09-06

Ground-level ozone is adverse to human and vegetation health. High ground-level ozone concentrations usually occur over the United States in the summer, often referred to as the ozone season. However, observed monthly mean ozone concentrations in the southeastern United States were higher in October than July in 2010. The October ozone average in 2010 reached that of July in the past three decades (1980-2010). Our analysis shows that this extreme October ozone in 2010 over the Southeast is due in part to a dry and warm weather condition, which enhances photochemical production, air stagnation, and fire emissions. Observational evidence and modeling analysis also indicate that another significant contributor is enhanced emissions of biogenic isoprene, a major ozone precursor, from water-stressed plants under a dry and warm condition. The latter finding is corroborated by recent laboratory and field studies. This climate-induced biogenic control also explains the puzzling fact that the two extremes of high October ozone both occurred in the 2000s when anthropogenic emissions were lower than the 1980s and 1990s, in contrast to the observed decreasing trend of July ozone in the region. The occurrences of a drying and warming fall, projected by climate models, will likely lead to more active photochemistry, enhanced biogenic isoprene and fire emissions, an extension of the ozone season from summer to fall, and an increase of secondary organic aerosols in the Southeast, posing challenges to regional air quality management.

Weather Typing-Based Flood Frequency Analysis Verified for Exceptional Historical Events of Past 500 Years Along the Meuse River

NASA Astrophysics Data System (ADS)

De Niel, J.; Demarée, G.; Willems, P.

2017-10-01

Governments, policy makers, and water managers are pushed by recent socioeconomic developments such as population growth and increased urbanization inclusive of occupation of floodplains to impose very stringent regulations on the design of hydrological structures. These structures need to withstand storms with return periods typically ranging between 1,250 and 10,000 years. Such quantification involves extrapolations of systematically measured instrumental data, possibly complemented by quantitative and/or qualitative historical data and paleoflood data. The accuracy of the extrapolations is, however, highly unclear in practice. In order to evaluate extreme river peak flow extrapolation and accuracy, we studied historical and instrumental data of the past 500 years along the Meuse River. We moreover propose an alternative method for the estimation of the extreme value distribution of river peak flows, based on weather types derived by sea level pressure reconstructions. This approach results in a more accurate estimation of the tail of the distribution, where current methods are underestimating the design levels related to extreme high return periods. The design flood for a 1,250 year return period is estimated at 4,800 m3 s-1 for the proposed method, compared with 3,450 and 3,900 m3 s-1 for a traditional method and a previous study.

Is extreme climate or moderate climate more conducive to longevity in China?

NASA Astrophysics Data System (ADS)

Huang, Yi; Rosenberg, Mark; Wang, Yingli

2018-02-01

Climate is closely related to human longevity. In China, there are many climate types. According to national population censuses from 1982 to 2000, most provinces with a high ratio of centenarians are located in western and northwestern China far from the sea; these areas are characterized by a dry, cold climate, very high altitude, very high daily temperature range, strong winds, and partial hypoxia. Meanwhile, provinces with a high ratio of nonagenarians from 1982 to 2000 are located in southern China near the sea. Previous studies have attributed the high ratio of centenarians in western and northwestern China to the extreme local climate. However, centenarians in these areas decreased greatly in 2010, whereas residents in southern China frequently reached 90 to 100 years old in 2010. This study aims to explain this strange phenomenon and find whether extreme climate in Tibetan plateau and northwestern China or moderate climate in southern China is more conducive to longevity. The study found that mortality rate in Tibetan plateau is much higher than southern China, then a population evolution experiment was proposed to compare longevity indicators between low mortality rate and high mortality rate and shows that longevity indicators will decrease in the near future and increase above their original levels after several decades when the mortality rate is decreased. Results of this study show individuals in northwestern China do not live as long as those in eastern and southern China. A moderate climate is more conducive to longevity than extreme climate in China. The longevity of a region should be judged by long-term longevity indicators.

Is extreme climate or moderate climate more conducive to longevity in China?

PubMed

Huang, Yi; Rosenberg, Mark; Wang, Yingli

2018-06-01

Climate is closely related to human longevity. In China, there are many climate types. According to national population censuses from 1982 to 2000, most provinces with a high ratio of centenarians are located in western and northwestern China far from the sea; these areas are characterized by a dry, cold climate, very high altitude, very high daily temperature range, strong winds, and partial hypoxia. Meanwhile, provinces with a high ratio of nonagenarians from 1982 to 2000 are located in southern China near the sea. Previous studies have attributed the high ratio of centenarians in western and northwestern China to the extreme local climate. However, centenarians in these areas decreased greatly in 2010, whereas residents in southern China frequently reached 90 to 100 years old in 2010. This study aims to explain this strange phenomenon and find whether extreme climate in Tibetan plateau and northwestern China or moderate climate in southern China is more conducive to longevity. The study found that mortality rate in Tibetan plateau is much higher than southern China, then a population evolution experiment was proposed to compare longevity indicators between low mortality rate and high mortality rate and shows that longevity indicators will decrease in the near future and increase above their original levels after several decades when the mortality rate is decreased. Results of this study show individuals in northwestern China do not live as long as those in eastern and southern China. A moderate climate is more conducive to longevity than extreme climate in China. The longevity of a region should be judged by long-term longevity indicators.

Is extreme climate or moderate climate more conducive to longevity in China?

NASA Astrophysics Data System (ADS)

Huang, Yi; Rosenberg, Mark; Wang, Yingli

2018-06-01

Climate is closely related to human longevity. In China, there are many climate types. According to national population censuses from 1982 to 2000, most provinces with a high ratio of centenarians are located in western and northwestern China far from the sea; these areas are characterized by a dry, cold climate, very high altitude, very high daily temperature range, strong winds, and partial hypoxia. Meanwhile, provinces with a high ratio of nonagenarians from 1982 to 2000 are located in southern China near the sea. Previous studies have attributed the high ratio of centenarians in western and northwestern China to the extreme local climate. However, centenarians in these areas decreased greatly in 2010, whereas residents in southern China frequently reached 90 to 100 years old in 2010. This study aims to explain this strange phenomenon and find whether extreme climate in Tibetan plateau and northwestern China or moderate climate in southern China is more conducive to longevity. The study found that mortality rate in Tibetan plateau is much higher than southern China, then a population evolution experiment was proposed to compare longevity indicators between low mortality rate and high mortality rate and shows that longevity indicators will decrease in the near future and increase above their original levels after several decades when the mortality rate is decreased. Results of this study show individuals in northwestern China do not live as long as those in eastern and southern China. A moderate climate is more conducive to longevity than extreme climate in China. The longevity of a region should be judged by long-term longevity indicators.

High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal

PubMed Central

Aguilar, Andres; Roemer, Gary; Debenham, Sally; Binns, Matthew; Garcelon, David; Wayne, Robert K.

2004-01-01

The San Nicolas Island fox (Urocyon littoralis dickeyi) is genetically the most monomorphic sexually reproducing animal population yet reported and has no variation in hypervariable genetic markers. Such low levels of variation imply lower resistance to pathogens, reduced fitness, and problems in distinguishing kin from non-kin. In vertebrates, the MHC contains genes that influence disease resistance and kin recognition and may be under intense balancing selection in some populations. Hence, genetic variation at the MHC might persist despite the extreme monomorphism shown by neutral markers. We examine variation of five loci within the MHC of San Nicolas Island foxes and find remarkably high levels of variation. Further, we show by simulation that genetic monomorphism at neutral loci and high MHC variation could arise only through an extreme population bottleneck of <10 individuals, ≈10–20 generations ago, accompanied by unprecedented selection coefficients of >0.5 on MHC loci. These results support the importance of balancing selection as a mechanism to maintain variation in natural populations and expose the difficulty of using neutral markers as surrogates for variation in fitness-related loci. PMID:14990802

Risk factors for upper-extremity musculoskeletal disorders in the working population

PubMed Central

Roquelaure, Yves; Ha, Catherine; Rouillon, Clarisse; Fouquet, Natacha; Leclerc, Annette; Descatha, Alexis; Touranchet, Annie; Goldberg, Marcel; Imbernon, Ellen

2009-01-01

SUMMARY Objective The study aimed to assess the relative importance of personal and occupational risk factors for upper-extremity musculoskeletal disorders (UEMSDs) in the working population. Methods A total of 3,710 workers (58% of men) participating in a surveillance program of MSDs in a French region in 2002–2005 were included. UEMSDs were diagnosed by 83 trained occupational physicians performing a standardized physical examination. Personal factors and work exposure were assessed by a self-administered questionnaire. Statistical associations between MSDs, personal and occupational factors were analyzed using logistic regression modeling. Results A total of 472 workers suffered from at least one UEMSD. The risk of UEMSDs increased with age for both genders (P<0.001) (O.R. up to 4.9 in men and 5.0 and in women) and in cases of prior history of UEMSDs (OR 3.1 and 5.0, P<0.001). In men, UEMSDs were associated with obesity (OR 2.2, P=0.014), high level of physical demand (OR 2.0, P<0.001), high repetitiveness of the task (OR 1.5, P=0.027), postures with the arms at or above shoulder level (OR 1.7, P=0.009) or with full elbow flexion (OR 1.6, P=0.006), and high psychological demand (O.R. 1.5, P=0.005). In women, UEMSDs were associated with diabetes mellitus (O.R. 4.9, P=0.001), postures with extreme wrist bending (OR 2.0, P<0.001), use of vibrating hand tools (O.R. 2.2, P=0.025) and low level of decision authority (OR 1.4, P=0.042). Conclusion The study showed that personal and work-related physical and psychosocial factors were strongly associated with clinically-diagnosed UEMSDs. PMID:19790112

Clinical characteristics of Japanese patients with severe hypertriglyceridemia.

PubMed

Tada, Hayato; Kawashiri, Masa-Aki; Nakahashi, Takuya; Yagi, Kunimasa; Chujo, Daisuke; Ohbatake, Azusa; Mori, Yukiko; Mori, Shunsuke; Kometani, Mitsuhiro; Fujii, Hiroshi; Nohara, Atsushi; Inazu, Akihiro; Mabuchi, Hiroshi; Yamagishi, Masakazu; Hayashi, Kenshi

2015-01-01

Although of interest, few data exist on the clinical characteristics of Japanese patients with an extremely high triglyceride level (≥ 1000 mg/dL). We assessed the clinical characteristics of Japanese patients with an extremely high triglyceride level. We investigated the presence of coronary artery disease, history of pancreatitis, the presence of fatty liver, and the potential causes of elevated triglyceride in Japanese subjects with an extremely high level of fasting triglyceride (≥ 1000 mg/dL) among 70,368 subjects whose serum triglyceride was measured for any reason at Kanazawa University Hospital from April 2004 to March 2014. We identified 215 (0.31%) subjects (mean age, 46 years; male, 170, mean body mass index, 25 kg/m(2)) with severe hypertriglyceridemia. Among them, 4 (1.9%) subjects were classified as type I, 97 (45.1%) subjects were type IV, and 114 (53.0%) subjects were type V hyperlipidemia, according to Fredrickson's classification. Among 215 subjects, 116 subjects (54.0%) drank alcohol, 58 (27.0%) showed heavy intake (≥ 60 g/d), and 64 (29.8%) subjects had diabetes. In total, 59 (27.4%) subjects had transient severe hypertriglyceridemia caused by corticosteroids (N = 19), antidepressant (N = 18), l-asparaginase and steroids for acute lymphoid leukemia (N = 15), hormone replacement therapy for breast cancer (N = 9), β-blocker (N = 5), hypothyroidism (N = 4), pregnancy (N = 4), and panhypopituitarism (N = 2). As many as 119 (55.3%) subjects exhibited fatty liver. Moreover, 12 (5.6%) and 17 (7.9%) subjects had a history of pancreatitis and coronary artery disease, respectively. A variety of situations can cause severe hypertriglyceridemia. We suggest that potential secondary causes should be carefully assessed for such patients. Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Participation level of the leprosy patients in society.

PubMed

Singh, S; Sinha, A K; Banerjee, B G; Jaswal, N

2009-01-01

The present study examines the soci-demographic profile and participation restriction level of the respondents and the association of gender socio-economic status (SES) and deformity status of the respondents with their respective participation restriction level. 245 leprosy patients have been selected for the present study. Socio-economic scale, participation scale and in-depth interviews were used for data collection. Data analysis was done by using statistical package for social sciences (SPSS). 57.1% belonged to poor SES followed by lower-middle (21.6%). Only 12% of respondents belonged to high SES. Out of 245 respondents, 32.20% had grade II deformity 31.40% grade I and the rest 36.3% non-deformed. The results of the participation scale showed that 54.28% had no significant participation restriction and only 3.67% had extreme participation restriction. SES and deformity status of the respondents have shown significant differences with the level of participation restriction. The lower the SES and the severe the level of deformity of the respondents, the extreme is the level of participation restriction among them.

Estimation of Future Return Levels for Heavy Rainfall in the Iberian Peninsula: Comparison of Methodologies

NASA Astrophysics Data System (ADS)

Parey, S.

2014-12-01

F. J. Acero1, S. Parey2, T.T.H. Hoang2, D. Dacunha-Castelle31Dpto. Física, Universidad de Extremadura, Avda. de Elvas s/n, 06006, Badajoz 2EDF/R&D, 6 quai Watier, 78401 Chatou Cedex, France 3Laboratoire de Mathématiques, Université Paris 11, Orsay, France Trends can already be detected in daily rainfall amount in the Iberian Peninsula (IP), and this will have an impact on the extreme levels. In this study, we compare different ways to estimate future return levels for heavy rainfall, based on the statistical extreme value theory. Both Peaks over Threshold (POT) and block maxima with the Generalized Extreme Value (GEV) distribution will be used and their results compared when linear trends are assumed in the parameters: threshold and scale parameter for POT and location and scale parameter for GEV. But rainfall over the IP is a special variable in that a large number of the values are 0. Thus, the impact of taking this into account is discussed too. Another approach is then tested, based on the evolutions of the mean and variance obtained from the time series of rainy days only, and of the number of rainy days. A statistical test, similar to that designed for temperature in Parey et al. 2013, is used to assess if the trends in extremes can be considered as mostly due to these evolutions when considering only rainy days. The results show that it is mainly the case: the extremes of the residuals, after removing the trends in mean and standard deviation, cannot be differentiated from those of a stationary process. Thus, the future return levels can be estimated from the stationary return level of these residuals and an estimation of the future mean and standard deviation. Moreover, an estimation of the future number of rainy days is used to retrieve the return levels for all days. All of these comparisons are made for an ensemble of high quality rainfall time series observed in the Iberian Peninsula over the period 1961-2010, from which we want to estimate a 20-year return level expected in 2020. The evolutions and the impact of the different approaches will be discussed for 3 seasons: fall, spring and winter. Parey S., Hoang T.T.H., Dacunha-Castelle D.: The importance of mean and variance in predicting changes in temperature extremes, Journal of Geophysical Research: Atmospheres, Vol. 118, 1-12, 2013.

Evaluation of Factors Affecting Acute Postoperative Pain Levels After Arthroscopic Rotator Cuff Repair.

PubMed

Cuff, Derek J; O'Brien, Kathleen C; Pupello, Derek R; Santoni, Brandon G

2016-07-01

To evaluate multiple preoperative and operative factors that may be predictive of and correlate with acute postoperative pain levels after arthroscopic rotator cuff repair. One hundred eighty-one patients underwent arthroscopic rotator cuff surgery along with subacromial decompression and met the inclusion criteria for this study. Postoperative visual analog scale (VAS) scores were obtained on postoperative days 1, 7, and 90. Multivariate linear regression analysis was used to correlate postoperative VAS scores with multiple independent factors, including preoperative subjective pain tolerance, preoperative VAS score, preoperative narcotic use, sex, smoking status, number of suture anchors used, tear size, single- or double-row repair, and patient age. Preoperative subjective pain tolerance, notably those patients rating themselves as having an extremely high pain tolerance, was the most significant predictor of high VAS pain scores on both postoperative day 1 (P = .0001) and postoperative day 7 (P < .0001). Preoperative narcotic use was also significantly predictive (P = .010) of high pain scores on postoperative day 1 and day 7 (P = .019), along with nonsmokers (P = .008) and younger patients (P = .006) being predictive on day 7. There were no patient factors that were predictive of VAS scores 3 months postoperatively (P = .567). Preoperative subjective pain tolerance, notably those patients rating themselves as having an extremely high pain tolerance, was the strongest factor predicting high acute pain levels after arthroscopic rotator cuff surgery. Preoperative narcotic use, smokers, and younger patients were also predictive of higher pain levels during the first postoperative week. Level IV, prognostic case series. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Impact of maternal education on cognitive and language scores at 18 to 24 months among extremely preterm neonates.

PubMed

Ko, Gary; Shah, Prakesh; Lee, Shoo K; Asztalos, Elizabeth

2013-10-01

To explore the association between maternal education levels and cognitive and language composite scores of the Bayley Scales of Infant Development, Third Edition at 18 to 24 months' corrected age in extremely preterm infants born at < 29 weeks of gestation. For infants born between 2005 and 2008, maternal education levels and the cognitive and language composite scores were collected. Analysis of covariance was used to determine the relationship between maternal education levels and composite scores after adjusting for neonatal and perinatal factors. For the study period, 457/524 (88%) infants were included in the analysis. With less than a high school education as reference, infants born to mothers with a high school education (adjusted mean difference [MD] = 5.4; 95% confidence interval [CI] 0.9 to 10.0), with partial college or specialty training (MD 8.1; 95% CI 2.8 to 13.5), with a university degree or more (MD 12.6; 95% CI 8.2 to 17.0) had significantly higher cognitive scores. Similarly, infants born to mothers with a university degree or more had significantly higher language scores (MD 10.8; 95% CI 6.1 to 15.5). For infants born at <29 weeks' gestation, both cognitive and language scores were higher as maternal education increased from less than high school level to university or higher level. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Deformation analysis and prediction of bank protection structure with river level fluctuations

NASA Astrophysics Data System (ADS)

Hu, Rui; Xing, Yixuan

2017-04-01

Bank structure is an important barrier to maintain the safety of the embankment. The deformation of bank protection structure is not only affected by soil pressure caused by the excavation of the riverway, but also by the water pressure caused river water level fluctuations. Thus, it is necessary to establish a coupled soil-water model to analyze the deformation of bank structure. Based on Druck-Prager failure criteria and groundwater seepage theory, a numerical model of bank protection structure with consideration of the pore water pressure of soil mass is established. According to the measured river level data with seasonal fluctuating, numerical analysis of the deformation of bank protection structure is implemented. The simulation results show that the river water level fluctuation has clear influence on the maximum lateral displacement of the pile. Meanwhile, the distribution of plastic zone is related to the depth of groundwater level. Finally, according to the river water level data of the recent ten years, we analyze the deformation of the bank structure under extreme river level. The result shows that, compared with the scenario of extreme high river level, the horizontal displacement of bank protection structure is larger (up to 65mm) under extreme low river level, which is a potential risk to the embankment. Reference Schweiger H F. On the use of drucker-prager failure criteria for earth pressure problems[J]. Computers and Geotechnics, 1994, 16(3): 223-246. DING Yong-chun，CHENG Ze-kun. Numerical study on performance of waterfront excavation[J]. Chinese Journal of Geotechnical Engineering，2013，35(2):515-521. Wu L M, Wang Z Q. Three gorges reservoir water level fluctuation influents on the stability of the slope[J]. Advanced Materials Research. Trans Tech Publications, 2013, 739: 283-286.

Atomic and electronic structures of an extremely fragile liquid.

PubMed

Kohara, Shinji; Akola, Jaakko; Patrikeev, Leonid; Ropo, Matti; Ohara, Koji; Itou, Masayoshi; Fujiwara, Akihiko; Yahiro, Jumpei; Okada, Junpei T; Ishikawa, Takehiko; Mizuno, Akitoshi; Masuno, Atsunobu; Watanabe, Yasuhiro; Usuki, Takeshi

2014-12-18

The structure of high-temperature liquids is an important topic for understanding the fragility of liquids. Here we report the structure of a high-temperature non-glass-forming oxide liquid, ZrO2, at an atomistic and electronic level. The Bhatia-Thornton number-number structure factor of ZrO2 does not show a first sharp diffraction peak. The atomic structure comprises ZrO5, ZrO6 and ZrO7 polyhedra with a significant contribution of edge sharing of oxygen in addition to corner sharing. The variety of large oxygen coordination and polyhedral connections with short Zr-O bond lifetimes, induced by the relatively large ionic radius of zirconium, disturbs the evolution of intermediate-range ordering, which leads to a reduced electronic band gap and increased delocalization in the ionic Zr-O bonding. The details of the chemical bonding explain the extremely low viscosity of the liquid and the absence of a first sharp diffraction peak, and indicate that liquid ZrO2 is an extremely fragile liquid.

Atomic and electronic structures of an extremely fragile liquid

PubMed Central

Kohara, Shinji; Akola, Jaakko; Patrikeev, Leonid; Ropo, Matti; Ohara, Koji; Itou, Masayoshi; Fujiwara, Akihiko; Yahiro, Jumpei; Okada, Junpei T.; Ishikawa, Takehiko; Mizuno, Akitoshi; Masuno, Atsunobu; Watanabe, Yasuhiro; Usuki, Takeshi

2014-01-01

The structure of high-temperature liquids is an important topic for understanding the fragility of liquids. Here we report the structure of a high-temperature non-glass-forming oxide liquid, ZrO2, at an atomistic and electronic level. The Bhatia–Thornton number–number structure factor of ZrO2 does not show a first sharp diffraction peak. The atomic structure comprises ZrO5, ZrO6 and ZrO7 polyhedra with a significant contribution of edge sharing of oxygen in addition to corner sharing. The variety of large oxygen coordination and polyhedral connections with short Zr–O bond lifetimes, induced by the relatively large ionic radius of zirconium, disturbs the evolution of intermediate-range ordering, which leads to a reduced electronic band gap and increased delocalization in the ionic Zr–O bonding. The details of the chemical bonding explain the extremely low viscosity of the liquid and the absence of a first sharp diffraction peak, and indicate that liquid ZrO2 is an extremely fragile liquid. PMID:25520236

A nested observation and model approach to non linear groundwater surface water interactions.

NASA Astrophysics Data System (ADS)

van der Velde, Y.; Rozemeijer, J. C.; de Rooij, G. H.

2009-04-01

Surface water quality measurements in The Netherlands are scattered in time and space. Therefore, water quality status and its variations and trends are difficult to determine. In order to reach the water quality goals according to the European Water Framework Directive, we need to improve our understanding of the dynamics of surface water quality and the processes that affect it. In heavily drained lowland catchment groundwater influences the discharge towards the surface water network in many complex ways. Especially a strong seasonal contracting and expanding system of discharging ditches and streams affects discharge and solute transport. At a tube drained field site the tube drain flux and the combined flux of all other flow routes toward a stretch of 45 m of surface water have been measured for a year. Also the groundwater levels at various locations in the field and the discharge at two nested catchment scales have been monitored. The unique reaction of individual flow routes on rainfall events at the field site allowed us to separate the discharge at a 4 ha catchment and at a 6 km2 into flow route contributions. The results of this nested experimental setup combined with the results of a distributed hydrological model has lead to the formulation of a process model approach that focuses on the spatial variability of discharge generation driven by temporal and spatial variations in groundwater levels. The main idea of this approach is that discharge is not generated by catchment average storages or groundwater heads, but is mainly generated by points scale extremes i.e. extreme low permeability, extreme high groundwater heads or extreme low surface elevations, all leading to catchment discharge. We focused on describing the spatial extremes in point scale storages and this led to a simple and measurable expression that governs the non-linear groundwater surface water interaction. We will present the analysis of the field site data to demonstrate the potential of nested-scale, high frequency observations. The distributed hydrological model results will be used to show transient catchment scale relations between groundwater levels and discharges. These analyses lead to a simple expression that can describe catchment scale groundwater surface water interactions.

The Complementary Role of High Sensitivity C-Reactive Protein in the Diagnosis and Severity Assessment of Autism

ERIC Educational Resources Information Center

Khakzad, Mohammad Reza; Javanbakht, Maryam; Shayegan, Mohammad Reza; Kianoush, Sina; Omid, Fatemeh; Hojati, Maryam; Meshkat, Mojtaba

2012-01-01

C-reactive protein (CRP) is a beneficial diagnostic test for the evaluation of inflammatory response. Extremely low levels of CRP can be detected using high-sensitivity CRP (hs-CRP) test. A considerable body of evidence has demonstrated that inflammatory response has an important role in the pathophysiology of autism. In this study, we evaluated…

Risk Factors for Lower-Extremity Injuries Among Contemporary Dance Students.

PubMed

van Seters, Christine; van Rijn, Rogier M; van Middelkoop, Marienke; Stubbe, Janine H

2017-10-10

To determine whether student characteristics, lower-extremity kinematics, and strength are risk factors for sustaining lower-extremity injuries in preprofessional contemporary dancers. Prospective cohort study. Codarts University of the Arts. Forty-five first-year students of Bachelor Dance and Bachelor Dance Teacher. At the beginning of the academic year, the injury history (only lower-extremity) and student characteristics (age, sex, educational program) were assessed using a questionnaire. Besides, lower-extremity kinematics [single-leg squat (SLS)], strength (countermovement jump) and height and weight (body mass index) were measured during a physical performance test. Substantial lower-extremity injuries during the academic year were defined as any problems leading to moderate or severe reductions in training volume or in performance, or complete inability to participate in dance at least once during follow-up as measured with the Oslo Sports Trauma Research Center (OSTRC) Questionnaire on Health Problems. Injuries were recorded on a monthly basis using a questionnaire. Analyses on leg-level were performed using generalized estimating equations to test the associations between substantial lower-extremity injuries and potential risk factors. The 1-year incidence of lower-extremity injuries was 82.2%. Of these, 51.4% was a substantial lower-extremity injury. Multivariate analyses identified that ankle dorsiflexion during the SLS (OR 1.25; 95% confidence interval, 1.03-1.52) was a risk factor for a substantial lower-extremity injury. The findings indicate that contemporary dance students are at high risk for lower-extremity injuries. Therefore, the identified risk factor (ankle dorsiflexion) should be considered for prevention purposes.

Factors affecting perioperative mortality and wound-related complications following major lower extremity amputations.

PubMed

Stone, Patrick A; Flaherty, Sarah K; Aburahma, Ali F; Hass, Stephen M; Jackson, J Michelle; Hayes, J David; Hofeldt, Matthew J; Hager, Casey S; Elmore, Michael S

2006-03-01

Major lower extremity amputations continue to be associated with significant morbidity and mortality, yet few recent large series have evaluated factors associated with perioperative mortality and wound complications. The purpose of this study was to examine factors affecting perioperative mortality and wound-related complications following major lower extremity amputation. A retrospective review was conducted of all adult patients who underwent nontraumatic major lower extremity amputations over a 5-year period at a single tertiary-care center in southern West Virginia. Demographic and clinical data, perioperative data, and outcomes were collected and analyzed to identify any relationship with perioperative mortality, as well as wound complications and early revisions (within 90 days) to a more proximal level. Variables were examined using chi-squared, two-tailed t-tests, and logistic regression. Three hundred eighty patients (61% male) underwent 412 major lower extremity amputations during 1999-2003. The initial level of amputation included 230 below-knee (BKA), 149 above-knee (AKA), and one hip disarticulation. Perioperative mortality was 15.5% (n = 59). From a regression model, age, albumin level, AKA, and lack of a previous coronary artery bypass graft (CABG) were independently related to mortality. Patients who did not have a previous CABG were nearly three times more likely to die than those who did (p = 0.038). Overall early wound complications were noted in 13.4% (n = 51). Four factors were independently related to experiencing a 90-day wound complication: BKA, community (rather than care facility) living, type of anesthesia, and preoperative hematocrit >30%. Major lower extremity amputation in patients with peripheral vascular disease continues to be associated with considerable perioperative morbidity and mortality. Even though the surgical procedure itself may not be challenging from a technical standpoint, underlying medical conditions put this group at high risk for perioperative death. Wound-healing problems are frequently encountered and must be minimized to facilitate early mobilization and hospital discharge.

1,4-Dioxane Remediation by Extreme Soil Vapor Extraction (XSVE). Screening-Level Feasibility Assessment and Design Tool in Support of 1,4-Dioxane Remediation by Extreme Soil Vapor Extraction (XSVE) ESTCP Project ER 201326

DTIC Science & Technology

2017-10-01

USER GUIDE 1,4-Dioxane Remediation by Extreme Soil Vapor Extraction (XSVE) Screening-Level Feasibility Assessment and Design Tool in...Support of 1,4-Dioxane Remediation by Extreme Soil Vapor Extraction (XSVE) ESTCP Project ER-201326 OCTOBER 2017 Rob Hinchee Integrated Science...Technology, Inc. 1509 Coastal Highway Panacea, FL 32346 8/8/2013 - 8/8/2018 10-2017 1,4-Dioxane Remediation by Extreme Soil Vapor Extraction (XSVE) Screening

Global predictability of temperature extremes

NASA Astrophysics Data System (ADS)

Coughlan de Perez, Erin; van Aalst, Maarten; Bischiniotis, Konstantinos; Mason, Simon; Nissan, Hannah; Pappenberger, Florian; Stephens, Elisabeth; Zsoter, Ervin; van den Hurk, Bart

2018-05-01

Extreme temperatures are one of the leading causes of death and disease in both developed and developing countries, and heat extremes are projected to rise in many regions. To reduce risk, heatwave plans and cold weather plans have been effectively implemented around the world. However, much of the world’s population is not yet protected by such systems, including many data-scarce but also highly vulnerable regions. In this study, we assess at a global level where such systems have the potential to be effective at reducing risk from temperature extremes, characterizing (1) long-term average occurrence of heatwaves and coldwaves, (2) seasonality of these extremes, and (3) short-term predictability of these extreme events three to ten days in advance. Using both the NOAA and ECMWF weather forecast models, we develop global maps indicating a first approximation of the locations that are likely to benefit from the development of seasonal preparedness plans and/or short-term early warning systems for extreme temperature. The extratropics generally show both short-term skill as well as strong seasonality; in the tropics, most locations do also demonstrate one or both. In fact, almost 5 billion people live in regions that have seasonality and predictability of heatwaves and/or coldwaves. Climate adaptation investments in these regions can take advantage of seasonality and predictability to reduce risks to vulnerable populations.

Prevention and management of infections associated with combat-related extremity injuries.

PubMed

Murray, Clinton K; Hsu, Joseph R; Solomkin, Joseph S; Keeling, John J; Andersen, Romney C; Ficke, James R; Calhoun, Jason H

2008-03-01

Orthopedic injuries suffered by casualties during combat constitute approximately 65% of the total percentage of injuries and are evenly distributed between upper and lower extremities. The high-energy explosive injuries, environmental contamination, varying evacuation procedures, and progressive levels of medical care make managing combat-related injuries challenging. The goals of orthopedic injury management are to prevent infection, promote fracture healing, and restore function. It appears that 2% to 15% of combat-related extremity injuries develop osteomyelitis, although lower extremity injuries are at higher risk of infections than upper extremity. Management strategies of combat-related injuries primarily focus on early surgical debridement and stabilization, antibiotic administration, and delayed primary closure. Herein, we provide evidence-based recommendations from military and civilian data to the management of combat-related injuries of the extremity. Areas of emphasis include the utility of bacterial cultures, antimicrobial therapy, irrigation fluids and techniques, timing of surgical care, fixation, antibiotic impregnated beads, wound closure, and wound coverage with negative pressure wound therapy. Most of the recommendations are not supported by randomized controlled trials or adequate cohorts studies in a military population and further efforts are needed to answer best treatment strategies.

Spatial Ecology of the Critically Endangered Fijian Crested Iguana, Brachylophus vitiensis, in an Extremely Dense Population: Implications for Conservation

PubMed Central

Morrison, Suzanne F.; Biciloa, Pita; Harlow, Peter S.; Keogh, J. Scott

2013-01-01

The Critically Endangered Fijian crested iguana, Brachylophus vitiensis, occurs at extreme density at only one location, with estimates of >10,000 iguanas living on the 70 hectare island of Yadua Taba in Fiji. We conducted a mark and recapture study over two wet seasons, investigating the spatial ecology and intraspecific interactions of the strictly arboreal Fijian crested iguana. This species exhibits moderate male-biased sexual size dimorphism, which has been linked in other lizard species to territoriality, aggression and larger male home ranges. We found that male Fijian crested iguanas exhibit high injury levels, indicative of frequent aggressive interactions. We did not find support for larger home range size in adult males relative to adult females, however male and female residents were larger than roaming individuals. Males with established home ranges also had larger femoral pores relative to body size than roaming males. Home range areas were small in comparison to those of other iguana species, and we speculate that the extreme population density impacts considerably on the spatial ecology of this population. There was extensive home range overlap within and between sexes. Intersexual overlap was greater than intrasexual overlap for both sexes, and continuing male-female pairings were observed among residents. Our results suggest that the extreme population density necessitates extensive home range overlap even though the underlying predictors of territoriality, such as male biased sexual size dimorphism and high aggression levels, remain. Our findings should be factored in to conservation management efforts for this species, particularly in captive breeding and translocation programs. PMID:24019902

Spatial ecology of the critically endangered Fijian crested iguana, Brachylophus vitiensis, in an extremely dense population: implications for conservation.

PubMed

Morrison, Suzanne F; Biciloa, Pita; Harlow, Peter S; Keogh, J Scott

2013-01-01

The Critically Endangered Fijian crested iguana, Brachylophus vitiensis, occurs at extreme density at only one location, with estimates of >10,000 iguanas living on the 70 hectare island of Yadua Taba in Fiji. We conducted a mark and recapture study over two wet seasons, investigating the spatial ecology and intraspecific interactions of the strictly arboreal Fijian crested iguana. This species exhibits moderate male-biased sexual size dimorphism, which has been linked in other lizard species to territoriality, aggression and larger male home ranges. We found that male Fijian crested iguanas exhibit high injury levels, indicative of frequent aggressive interactions. We did not find support for larger home range size in adult males relative to adult females, however male and female residents were larger than roaming individuals. Males with established home ranges also had larger femoral pores relative to body size than roaming males. Home range areas were small in comparison to those of other iguana species, and we speculate that the extreme population density impacts considerably on the spatial ecology of this population. There was extensive home range overlap within and between sexes. Intersexual overlap was greater than intrasexual overlap for both sexes, and continuing male-female pairings were observed among residents. Our results suggest that the extreme population density necessitates extensive home range overlap even though the underlying predictors of territoriality, such as male biased sexual size dimorphism and high aggression levels, remain. Our findings should be factored in to conservation management efforts for this species, particularly in captive breeding and translocation programs.

Support Systems after Divorce: Incidence and Impact.

ERIC Educational Resources Information Center

Colletta, Nancy Donahue

1979-01-01

Examined the impact of support systems on post-divorce family functioning. Results suggest that families under extreme stress need to be provided with relatively high levels of support or their dissatisfaction with support systems will appear in harsher and more restrictive relationships with children. (Author)

A longitudinal study of ice hockey in boys aged 8--12.

PubMed

MacNab, R B

1979-03-01

A group of fifteen boys (experimental or competitive) were studied over a five year period of competitive ice hockey beginning at age 8. The subjects were members of a team which averaged 66 games per year, ranging from 50 at age 8 to 78 at age 12. In addition, they practiced twice a week with heavy stress on skating and individual puck handling skills. A second group of eleven boys (control or less competitive) were studied from age 10 to 12. The latter subjects played an average of 25 games per year and practiced once a week. All subjects were measured each year on skating and puck control skills, fitness-performance tests, grip strength, physical work capacity as well as height and weight. The results demonstrate learning curves for skating and puck control tests which, while typical in nature, show extremely high levels of achievement. Fitness-Performance, grip strength and physical work capacity levels of the competitive group are extremely high in comparison with data from other countries.

Complex Socio-Ecological Dynamics driven by extreme events in the Amazon

NASA Astrophysics Data System (ADS)

Pinho, P. F.

2015-12-01

Several years with extreme floods or droughts in the past decade have caused human suffering in remote communities of the Brazilian Amazon. Despite documented local knowledge and practices for coping with the high seasonal variability characteristic of the region's hydrology (e.g. 10m change in river levels between dry and flood seasons), and despite 'civil Defense' interventions by various levels of government, the more extreme years seem to have exceeded the coping capacity of the community. In this paper, we explore whether there is a real increase in variability, whether the community perceives that recent extreme events are outside the experience which shapes their responses to 'normal' levels of variability, and what science-based policy could contribute to greater local resilience. Hydrological analyses suggest that variability is indeed increasing, in line with expectations from future climate change. However, current measures of hydrological regimes do not predict years with social hardship very well. Interviewees in two regions are able to express their strategies for dealing with 'normal' variability very well, but also identify ways in which abnormal years exceed their ability to cope. Current Civil Defense arrangements struggle to deliver emergency assistance in a sufficiently timely and locally appropriate fashion. Combining these insights in the context of social-ecological change, we suggest how better integration of science, policy and local knowledge could improve resilience to future trends, and identify some contributions science could make into such an arrangement.

Prognostic factors of a satisfactory functional result in patients with unilateral amputations of the upper limb above the wrist that use an upper limb prosthesis.

PubMed

Dabaghi-Richerand, A; Haces-García, F; Capdevila-Leonori, R

2015-01-01

The purpose of this study is to determine the prognostic factors of a satisfactory functional outcome in patients using upper extremity prosthetics with a proximal third forearm stump, and above, level of amputation. All patients with longitudinal deficiencies and traumatic amputations of upper extremity with a level of amputation of proximal third forearm and above were included. A total of 49 patients with unilateral upper extremity amputations that had used the prosthetic for a minimum of 2 years were included in the protocol. The Disability arm shoulder hand (DASH) scale was used to determine a good result with a cut-off of less than 40%. The independent variables were the level of amputation, the etiology for its use, initial age of use and number of hours/day using the prosthesis. It was found that patients with a congenital etiology and those that started using the prosthetic before 6 years of age had better functional results. It was found that when adapting a patient with an upper extremity prosthetic, which has a high rejection rate of up to 49%, better functional outcomes are found in those who started using it before 6 years of age, and preferably because of a congenital etiology. It was also found that the number of hours/day strongly correlates with a favorable functional outcome. Copyright © 2014 SECOT. Published by Elsevier Espana. All rights reserved.

Organochlorine pesticides, PCBs, dibenzodioxin, and furan concentrations in common snapping turtle eggs (Chelydra serpentina serpentina) in Akwesasne, Mohawk Territory, Ontario, Canada.

PubMed

de Solla, S R; Bishop, C A; Lickers, H; Jock, K

2001-04-01

Subsamples of eight clutches of common snapping turtle eggs (Chelydra serpentina serpentina) were collected from four sites from the territory of the Mohawk Nation, Akwesasne, on the shore of the St. Lawrence River. Egg contents were analyzed for organochlorine pesticides, polychlorinated biphenyls (PCBs), dibenzodioxins, and furans. The sites were 2 to 13 km downstream from PCB-contaminated landfill sites. Maximum concentrations of total PCBs in snapping turtle clutches were extremely high, and ranged from 2 378.2 ng/g to 737 683 ng/g (wet weight) and are among the highest recorded in any tissue of a free-ranging animal. Similarly, in a pooled sample of eggs from all four sites, the summed concentrations of non-ortho PCBs (n = 6 congeners) was also very high at 54.54 ng/g and the summed dioxin and furan concentrations (n = 11 congeners) was 85.8 ng/g. Sum organochlorine pesticide levels varied from 28 to 2,264 ng/g among the four sites. The levels of PCBs found in turtle eggs exceed concentrations associated with developmental problems and reduced hatching success in snapping turtles and other species and also exceed the Canadian tissue residue guidelines for toxic equivalency concentrations. The extremely high levels of organochlorine contaminants demonstrate the high degree of contamination in the environment in the Akwesasne area.

Solid wastes from nuclear power production.

PubMed Central

Soule, H F

1978-01-01

Radioactivity in nuclear power effluents is negligible compared to that in retained wastes to be disposed of as solids. Two basic waste categories are those for which shallow disposal is accepted and those for which more extreme isolation is desired. The latter includes "high level" wastes and others contaminated with radionuclides with the unusual combined properties of long radioactive half-life and high specific radiotoxicity. The favored method for extreme isolation is emplacement in a deep stable geologic formation. Necessary technologies for waste treatment and disposal are considered available. The present program to implement these technologies is discussed, including the waste management significance of current policy on spent nuclear fuel reprocessing. Recent difficulties with shallow disposal of waste are summarized. PMID:738244

Practical considerations in the development of hemoglobin-based oxygen therapeutics.

PubMed

Kim, Hae Won; Estep, Timothy N

2012-09-01

The development of hemoglobin based oxygen therapeutics (HBOCs) requires consideration of a number of factors. While the enabling technology derives from fundamental research on protein biochemistry and biological interactions, translation of these research insights into usable medical therapeutics demands the application of considerable technical expertise and consideration and reconciliation of a myriad of manufacturing, medical, and regulatory requirements. The HBOC development challenge is further exacerbated by the extremely high intravenous doses required for many of the indications contemplated for these products, which in turn implies an extremely high level of purity is required. This communication discusses several of the important product configuration and developmental considerations that impact the translation of fundamental research discoveries on HBOCs into usable medical therapeutics.

Effect of Fuel Injection and Mixing Characteristics on Pulse-Combustor Performance at High-Pressure

NASA Technical Reports Server (NTRS)

Yungster, Shaye; Paxson, Daniel E.; Perkins, Hugh D.

2014-01-01

Recent calculations of pulse-combustors operating at high-pressure conditions produced pressure gains significantly lower than those observed experimentally and computationally at atmospheric conditions. The factors limiting the pressure-gain at high-pressure conditions are identified, and the effects of fuel injection and air mixing characteristics on performance are investigated. New pulse-combustor configurations were developed, and the results show that by suitable changes to the combustor geometry, fuel injection scheme and valve dynamics the performance of the pulse-combustor operating at high-pressure conditions can be increased to levels comparable to those observed at atmospheric conditions. In addition, the new configurations can significantly reduce the levels of NOx emissions. One particular configuration resulted in extremely low levels of NO, producing an emission index much less than one, although at a lower pressure-gain. Calculations at representative cruise conditions demonstrated that pulse-combustors can achieve a high level of performance at such conditions.

Extreme cyclone events in the Arctic during wintertime: Variability and Trends

NASA Astrophysics Data System (ADS)

Rinke, Annette; Maturilli, Marion; Graham, Robert; Matthes, Heidrun; Handorf, Doerthe; Cohen, Lana; Hudson, Stephen; Moore, John

2017-04-01

Extreme cyclone events are of significant interest as they can transport much heat, moisture, and momentum poleward. Associated impacts are warming and sea-ice breakup. Recently, several examples of such extreme weather events occurred in winter (e.g. during the N-ICE2015 campaign north of Svalbard and the Frank North Atlantic storm during the end of December 2015). With Arctic amplification and associated reduced sea-ice cover and warmer sea surface temperatures, the occurrence of extreme cyclones events could be a plausible scenario. We calculate the spatial patterns, and changes and trends of the number of extreme cyclone events in the Arctic based on ERA-Interim six-hourly sea level pressure (SLP) data for winter (November-February) 1979-2015. Further, we analyze the SLP data from the Ny Alesund station for the same 37 year period. We define an extreme cyclone event by a extreme low central pressure (SLP below 985 hPa, which is the 5th percentile of the Ny Alesund/N-ICE2015 SLP data) and a deepening of at least 6 hPa/6 hours. Areas of highest frequency of occurrence of extreme cyclones are south/southeast of Greenland (corresponding to the Islandic low), between Norway and Svalbard and in the Barents/Kara Seas. The time series of the number of occurrence of extreme cyclone events for Ny Alesund/N-ICE show considerable interannual variability. The trend is not consistent through the winter, but we detect an increase in early winter and a slight decrease in late winter. The former is due to the increased occurrence of longer events at the expense of short events. Furthermore, the difference patterns of the frequency of events for months following the September with high and low Arctic sea-ice extent ("Low minus high sea ice") conforms with the change patterns of extreme cyclones numbers (frequency of events "2000-2015 minus 1979-1994") and with the trend patterns. This indicates that the changes in extreme cyclone occurrence in early winter are associated with sea-ice changes (regional feedback). In contrast, different mechanisms via large-scale circulation changes/teleconnections seem to play a role in late winter.

An Extreme Hailstorm on 27 July 2017 in Istanbul, Turkey: Synoptic Scale Circulation and Thermodynamic Evaluation

NASA Astrophysics Data System (ADS)

Baltaci, Hakki; Akkoyunlu, Bulent Oktay; Tayanc, Mete

2018-03-01

During the afternoon hours of July 27, 2017, an extreme hailstorm struck the most populated city of Turkey, Istanbul. This rapidly growing supercell which produces large hail led to numerous injuries and damaged automobiles, houses, aircrafts, crops, and infrastructure of the city. As a result of the movement of the cut-off cyclone from Middle East to western Turkey, warm air advection penetrated over Marmara, and the land surface temperature of Istanbul reached 34 °C (5 °C above the mean). The transport of significant amount of moisture, which was caused by excessive heating of Marmara Sea surface temperatures (24.9 °C), to the low levels of the atmosphere by strong southwesterly winds enabled the increase of low-level moisture convergence. Both abnormal temperature differences between land and 500-hPa level (41.5 °C) and excessive wind shear values (20.3 m/s) between surface and 6 km above ground level (AGL) increased the thermal instability and updraft conditions of the baroclinic atmosphere. This condition resulted in thunderstorms, stormy and gale wind gusts (31.9 m/s 15:20 UTC), extreme lightning activity (totally 2696 cloud-to-ground and 5791 intracloud), large hailstones between 3-6 cm diameter and high hourly precipitation amounts (38.7, 36.2, 29.8, and 27.2 mm in Sisli, Kadikoy, Uskudar, and Fatih regions, respectively, between 14:00 and 15:00 UTC) in the urban settlements of the city. The stability indices, Showalter, K, Total of totals, SWEAT, and CAPE also showed the high probability of severe thunderstorm occurrence over Istanbul. Based on a comparison among these five indices, the SWEAT index is most appropriate to represent the atmospheric conditions over the city owing to low-level moisture, warm air advection, and low and mid-level wind speed terms in its equation.

A trauma-like model of political extremism: psycho-political fault lines in Israel.

PubMed

Laor, Nathaniel; Yanay-Shani, Alma; Wolmer, Leo; Khoury, Oula

2010-10-01

This study examines a trauma-like model of potentially violent political extremism among Jewish Israelis. We study the psychosocial characteristics of political extremists that may lie at the root of sociopolitical instability and assess personal (gender, stressful life events, Holocaust family background, and political activism) and psychological parameters (self- and political transcendence, perceived political threats, in/out-group identification ratio) that may predict readiness to engage in destructive political behavior. We examine the ideological zeal of various political groups, the relationship between the latter and perceived political threats, and the predictors of extreme political activism. Results showed that the extreme political poles displayed high level of ideological and morbid transcendence. Right extremists displayed higher perceived threats to physical existence and national identity. Left extremists scored highest on perceived moral integrity threat. Higher perceived threats to national identity and moral integrity, risk, and self-transcendence statistically explain morbid transcendence. When fear conjures up extremely skewed sociopolitical identifications across political boundaries, morbid transcendence may manifest itself in destructive political activity. © 2010 Association for Research in Nervous and Mental Disease.

Survival in extreme environments - on the current knowledge of adaptations in tardigrades.

PubMed

Møbjerg, N; Halberg, K A; Jørgensen, A; Persson, D; Bjørn, M; Ramløv, H; Kristensen, R M

2011-07-01

Tardigrades are microscopic animals found worldwide in aquatic as well as terrestrial ecosystems. They belong to the invertebrate superclade Ecdysozoa, as do the two major invertebrate model organisms: Caenorhabditis elegans and Drosophila melanogaster. We present a brief description of the tardigrades and highlight species that are currently used as models for physiological and molecular investigations. Tardigrades are uniquely adapted to a range of environmental extremes. Cryptobiosis, currently referred to as a reversible ametabolic state induced by e.g. desiccation, is common especially among limno-terrestrial species. It has been shown that the entry and exit of cryptobiosis may involve synthesis of bioprotectants in the form of selective carbohydrates and proteins as well as high levels of antioxidant enzymes and other free radical scavengers. However, at present a general scheme of mechanisms explaining this phenomenon is lacking. Importantly, recent research has shown that tardigrades even in their active states may be extremely tolerant to environmental stress, handling extreme levels of ionizing radiation, large fluctuation in external salinity and avoiding freezing by supercooling to below -20 °C, presumably relying on efficient DNA repair mechanisms and osmoregulation. This review summarizes the current knowledge on adaptations found among tardigrades, and presents new data on tardigrade cell numbers and osmoregulation. © 2011 The Authors. Acta Physiologica © 2011 Scandinavian Physiological Society.

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans.

PubMed

Pyle, Angela; Hudson, Gavin; Wilson, Ian J; Coxhead, Jonathan; Smertenko, Tania; Herbert, Mary; Santibanez-Koref, Mauro; Chinnery, Patrick F

2015-05-01

Recent reports have questioned the accepted dogma that mammalian mitochondrial DNA (mtDNA) is strictly maternally inherited. In humans, the argument hinges on detecting a signature of inter-molecular recombination in mtDNA sequences sampled at the population level, inferring a paternal source for the mixed haplotypes. However, interpreting these data is fraught with difficulty, and direct experimental evidence is lacking. Using extreme-high depth mtDNA re-sequencing up to ~1.2 million-fold coverage, we find no evidence that paternal mtDNA haplotypes are transmitted to offspring in humans, thus excluding a simple dilution mechanism for uniparental transmission of mtDNA present in all healthy individuals. Our findings indicate that an active mechanism eliminates paternal mtDNA which likely acts at the molecular level.

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans

PubMed Central

Pyle, Angela; Hudson, Gavin; Wilson, Ian J.; Coxhead, Jonathan; Smertenko, Tania; Herbert, Mary; Santibanez-Koref, Mauro; Chinnery, Patrick F.

2015-01-01

Recent reports have questioned the accepted dogma that mammalian mitochondrial DNA (mtDNA) is strictly maternally inherited. In humans, the argument hinges on detecting a signature of inter-molecular recombination in mtDNA sequences sampled at the population level, inferring a paternal source for the mixed haplotypes. However, interpreting these data is fraught with difficulty, and direct experimental evidence is lacking. Using extreme-high depth mtDNA re-sequencing up to ~1.2 million-fold coverage, we find no evidence that paternal mtDNA haplotypes are transmitted to offspring in humans, thus excluding a simple dilution mechanism for uniparental transmission of mtDNA present in all healthy individuals. Our findings indicate that an active mechanism eliminates paternal mtDNA which likely acts at the molecular level. PMID:25973765

Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments

PubMed Central

Yang, Ji; Li, Wen-Rong; Lv, Feng-Hua; He, San-Gang; Tian, Shi-Lin; Peng, Wei-Feng; Sun, Ya-Wei; Zhao, Yong-Xin; Tu, Xiao-Long; Zhang, Min; Xie, Xing-Long; Wang, Yu-Tao; Li, Jin-Quan; Liu, Yong-Gang; Shen, Zhi-Qiang; Wang, Feng; Liu, Guang-Jian; Lu, Hong-Feng; Kantanen, Juha; Han, Jian-Lin; Li, Meng-Hua; Liu, Ming-Jun

2016-01-01

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8–9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. PMID:27401233

Response of shoal grass, Halodule wrightii, to extreme winter conditions in the Lower Laguna Madre, Texas

USGS Publications Warehouse

Hicks, D.W.; Onuf, C.P.; Tunnell, J.W.

1998-01-01

Effects of a severe freeze on the shoal grass, Halodule wrightii, were documented through analysis of temporal and spatial trends in below-ground biomass. The coincidence of the second lowest temperature (-10.6??C) in 107 years of record, 56 consecutive hours below freezing, high winds and extremely low water levels exposed the Laguna Madre, TX, to the most severe cold stress in over a century. H. wrightii tolerated this extreme freeze event. Annual pre- and post-freeze surveys indicated that below-ground biomass estimated from volume was Unaffected by the freeze event. Nor was there any post-freeze change in biomass among intertidal sites directly exposed to freezing air temperatures relative to subtidal sites which remained submerged during the freezing period.

Determining the Extremes of the Cellular NAD(H) Level by Using an Escherichia coli NAD+-Auxotrophic Mutant ▿

PubMed Central

Zhou, Yongjin; Wang, Lei; Yang, Fan; Lin, Xinping; Zhang, Sufang; Zhao, Zongbao K.

2011-01-01

NAD (NAD+) and its reduced form (NADH) are omnipresent cofactors in biological systems. However, it is difficult to determine the extremes of the cellular NAD(H) level in live cells because the NAD+ level is tightly controlled by a biosynthesis regulation mechanism. Here, we developed a strategy to determine the extreme NAD(H) levels in Escherichia coli cells that were genetically engineered to be NAD+ auxotrophic. First, we expressed the ntt4 gene encoding the NAD(H) transporter in the E. coli mutant YJE001, which had a deletion of the nadC gene responsible for NAD+ de novo biosynthesis, and we showed NTT4 conferred on the mutant strain better growth in the presence of exogenous NAD+. We then constructed the NAD+-auxotrophic mutant YJE003 by disrupting the essential gene nadE, which is responsible for the last step of NAD+ biosynthesis in cells harboring the ntt4 gene. The minimal NAD+ level was determined in M9 medium in proliferating YJE003 cells that were preloaded with NAD+, while the maximal NAD(H) level was determined by exposing the cells to high concentrations of exogenous NAD(H). Compared with supplementation of NADH, cells grew faster and had a higher intracellular NAD(H) level when NAD+ was fed. The intracellular NAD(H) level increased with the increase of exogenous NAD+ concentration, until it reached a plateau. Thus, a minimal NAD(H) level of 0.039 mM and a maximum of 8.49 mM were determined, which were 0.044× and 9.6× those of wild-type cells, respectively. Finally, the potential application of this strategy in biotechnology is briefly discussed. PMID:21742902

Large-Scale Meteorological Patterns Associated with Extreme Precipitation in the US Northeast

NASA Astrophysics Data System (ADS)

Agel, L. A.; Barlow, M. A.

2016-12-01

Patterns of daily large-scale circulation associated with Northeast US extreme precipitation are identified using both k-means clustering (KMC) and Self-Organizing Maps (SOM) applied to tropopause height. Tropopause height provides a compact representation of large-scale circulation patterns, as it is linked to mid-level circulation, low-level thermal contrasts and low-level diabatic heating. Extreme precipitation is defined as the top 1% of daily wet-day observations at 35 Northeast stations, 1979-2008. KMC is applied on extreme precipitation days only, while the SOM algorithm is applied to all days in order to place the extreme results into a larger context. Six tropopause patterns are identified on extreme days: a summertime tropopause ridge, a summertime shallow trough/ridge, a summertime shallow eastern US trough, a deeper wintertime eastern US trough, and two versions of a deep cold-weather trough located across the east-central US. Thirty SOM patterns for all days are identified. Results for all days show that 6 SOM patterns account for almost half of the extreme days, although extreme precipitation occurs in all SOM patterns. The same SOM patterns associated with extreme precipitation also routinely produce non-extreme precipitation; however, on extreme precipitation days the troughs, on average, are deeper and the downstream ridges more pronounced. Analysis of other fields associated with the large-scale patterns show various degrees of anomalously strong upward motion during, and moisture transport preceding, extreme precipitation events.

Spatial Intensity Duration Frequency Relationships Using Hierarchical Bayesian Analysis for Urban Areas

NASA Astrophysics Data System (ADS)

Rupa, Chandra; Mujumdar, Pradeep

2016-04-01

In urban areas, quantification of extreme precipitation is important in the design of storm water drains and other infrastructure. Intensity Duration Frequency (IDF) relationships are generally used to obtain design return level for a given duration and return period. Due to lack of availability of extreme precipitation data for sufficiently large number of years, estimating the probability of extreme events is difficult. Typically, a single station data is used to obtain the design return levels for various durations and return periods, which are used in the design of urban infrastructure for the entire city. In an urban setting, the spatial variation of precipitation can be high; the precipitation amounts and patterns often vary within short distances of less than 5 km. Therefore it is crucial to study the uncertainties in the spatial variation of return levels for various durations. In this work, the extreme precipitation is modeled spatially using the Bayesian hierarchical analysis and the spatial variation of return levels is studied. The analysis is carried out with Block Maxima approach for defining the extreme precipitation, using Generalized Extreme Value (GEV) distribution for Bangalore city, Karnataka state, India. Daily data for nineteen stations in and around Bangalore city is considered in the study. The analysis is carried out for summer maxima (March - May), monsoon maxima (June - September) and the annual maxima rainfall. In the hierarchical analysis, the statistical model is specified in three layers. The data layer models the block maxima, pooling the extreme precipitation from all the stations. In the process layer, the latent spatial process characterized by geographical and climatological covariates (lat-lon, elevation, mean temperature etc.) which drives the extreme precipitation is modeled and in the prior level, the prior distributions that govern the latent process are modeled. Markov Chain Monte Carlo (MCMC) algorithm (Metropolis Hastings algorithm within a Gibbs sampler) is used to obtain the samples of parameters from the posterior distribution of parameters. The spatial maps of return levels for specified return periods, along with the associated uncertainties, are obtained for the summer, monsoon and annual maxima rainfall. Considering various covariates, the best fit model is selected using Deviance Information Criteria. It is observed that the geographical covariates outweigh the climatological covariates for the monsoon maxima rainfall (latitude and longitude). The best covariates for summer maxima and annual maxima rainfall are mean summer precipitation and mean monsoon precipitation respectively, including elevation for both the cases. The scale invariance theory, which states that statistical properties of a process observed at various scales are governed by the same relationship, is used to disaggregate the daily rainfall to hourly scales. The spatial maps of the scale are obtained for the study area. The spatial maps of IDF relationships thus generated are useful in storm water designs, adequacy analysis and identifying the vulnerable flooding areas.

Segmentectomy for giant pulmonary sclerosing haemangiomas with high serum KL-6 levels

PubMed Central

Kuroda, Hiroaki; Mun, Mingyon; Okumura, Sakae; Nakagawa, Ken

2012-01-01

We describe a 61-year old female patient with a giant pulmonary sclerosing haemangioma (PSH) and an extremely high preoperative serum KL-6 level. During an annual health screening, the patient showed a posterior mediastinal mass on chest radiography. Chest computed tomography and magnetic resonance imaging revealed a well-circumscribed 60 mm diameter nodule with a marked contrast enhancement in the left lower lobe. The preoperative serum KL-6 level was elevated to 8204 U/ml. We performed a four-port thoracoscopic basal segmentectomy and lymph node sampling for diagnosis and therapy. The postoperative diagnosis showed PSH. The serum KL-6 level decreased dramatically with tumour resection. To the best of our knowledge, this is the first report of a patient with PSH showing a high serum KL-6 level. PMID:22454483

Leaf Area Index Drives Soil Water Availability and Extreme Drought-Related Mortality under Elevated CO2 in a Temperate Grassland Model System

PubMed Central

Manea, Anthony; Leishman, Michelle R.

2014-01-01

The magnitude and frequency of climatic extremes, such as drought, are predicted to increase under future climate change conditions. However, little is known about how other factors such as CO2 concentration will modify plant community responses to these extreme climatic events, even though such modifications are highly likely. We asked whether the response of grasslands to repeat extreme drought events is modified by elevated CO2, and if so, what are the underlying mechanisms? We grew grassland mesocosms consisting of 10 co-occurring grass species common to the Cumberland Plain Woodland of western Sydney under ambient and elevated CO2 and subjected them to repeated extreme drought treatments. The 10 species included a mix of C3, C4, native and exotic species. We hypothesized that a reduction in the stomatal conductance of the grasses under elevated CO2 would be offset by increases in the leaf area index thus the retention of soil water and the consequent vulnerability of the grasses to extreme drought would not differ between the CO2 treatments. Our results did not support this hypothesis: soil water content was significantly lower in the mesocosms grown under elevated CO2 and extreme drought-related mortality of the grasses was greater. The C4 and native grasses had significantly higher leaf area index under elevated CO2 levels. This offset the reduction in the stomatal conductance of the exotic grasses as well as increased rainfall interception, resulting in reduced soil water content in the elevated CO2 mesocosms. Our results suggest that projected increases in net primary productivity globally of grasslands in a high CO2 world may be limited by reduced soil water availability in the future. PMID:24632832

Leaf area index drives soil water availability and extreme drought-related mortality under elevated CO2 in a temperate grassland model system.

PubMed

Manea, Anthony; Leishman, Michelle R

2014-01-01

The magnitude and frequency of climatic extremes, such as drought, are predicted to increase under future climate change conditions. However, little is known about how other factors such as CO2 concentration will modify plant community responses to these extreme climatic events, even though such modifications are highly likely. We asked whether the response of grasslands to repeat extreme drought events is modified by elevated CO2, and if so, what are the underlying mechanisms? We grew grassland mesocosms consisting of 10 co-occurring grass species common to the Cumberland Plain Woodland of western Sydney under ambient and elevated CO2 and subjected them to repeated extreme drought treatments. The 10 species included a mix of C3, C4, native and exotic species. We hypothesized that a reduction in the stomatal conductance of the grasses under elevated CO2 would be offset by increases in the leaf area index thus the retention of soil water and the consequent vulnerability of the grasses to extreme drought would not differ between the CO2 treatments. Our results did not support this hypothesis: soil water content was significantly lower in the mesocosms grown under elevated CO2 and extreme drought-related mortality of the grasses was greater. The C4 and native grasses had significantly higher leaf area index under elevated CO2 levels. This offset the reduction in the stomatal conductance of the exotic grasses as well as increased rainfall interception, resulting in reduced soil water content in the elevated CO2 mesocosms. Our results suggest that projected increases in net primary productivity globally of grasslands in a high CO2 world may be limited by reduced soil water availability in the future.

Evaluation of large-scale meteorological patterns associated with temperature extremes in the NARCCAP regional climate model simulations

NASA Astrophysics Data System (ADS)

Loikith, Paul C.; Waliser, Duane E.; Lee, Huikyo; Neelin, J. David; Lintner, Benjamin R.; McGinnis, Seth; Mearns, Linda O.; Kim, Jinwon

2015-12-01

Large-scale meteorological patterns (LSMPs) associated with temperature extremes are evaluated in a suite of regional climate model (RCM) simulations contributing to the North American Regional Climate Change Assessment Program. LSMPs are characterized through composites of surface air temperature, sea level pressure, and 500 hPa geopotential height anomalies concurrent with extreme temperature days. Six of the seventeen RCM simulations are driven by boundary conditions from reanalysis while the other eleven are driven by one of four global climate models (GCMs). Four illustrative case studies are analyzed in detail. Model fidelity in LSMP spatial representation is high for cold winter extremes near Chicago. Winter warm extremes are captured by most RCMs in northern California, with some notable exceptions. Model fidelity is lower for cool summer days near Houston and extreme summer heat events in the Ohio Valley. Physical interpretation of these patterns and identification of well-simulated cases, such as for Chicago, boosts confidence in the ability of these models to simulate days in the tails of the temperature distribution. Results appear consistent with the expectation that the ability of an RCM to reproduce a realistically shaped frequency distribution for temperature, especially at the tails, is related to its fidelity in simulating LMSPs. Each ensemble member is ranked for its ability to reproduce LSMPs associated with observed warm and cold extremes, identifying systematically high performing RCMs and the GCMs that provide superior boundary forcing. The methodology developed here provides a framework for identifying regions where further process-based evaluation would improve the understanding of simulation error and help guide future model improvement and downscaling efforts.

Extreme Sea Level Rise Event Linked to 2009-10 AMOC Downturn

NASA Astrophysics Data System (ADS)

Yin, J.

2016-02-01

The coastal sea levels along the Northeast Coast of North America show significant year-to-year fluctuations in a general upward trend. Our analysis of long-term tide gauge records along the North American east coast identified an extreme sea-level rise (SLR) event during 2009-2010. Within this relatively brief two-year period, coastal sea levels north of New York City jumped by 100 mm. This magnitude of inter-annual SLR is unprecedented in the century-long tide gauge records, with statistical methods suggesting that it was a 1-in-850 year event. We show that this extreme SLR event was a combined effect of two physical factors. First, it was partly due to an observed 30% downturn of the Atlantic meridional overturning circulation (AMOC) during 2009-2010. This AMOC slowdown caused a significant decline of the dynamic sea level gradient across the Gulf Stream and North Atlantic Current, thereby imparting a rise in coastal sea level. The second contributing factor to the extreme SLR event was due to a significant negative North Atlantic Oscillation (NAO) index. The associated easterly or northeasterly wind anomalies acted to push ocean waters towards the Northeast Coast through the Ekman transport, resulting in further rise in coastal sea levels. Sea level pressure anomalies also contributed to the extreme SLR event through the inverse barometer effect. To project future extreme sea levels along the east coast of North America during the 21st century, we make use of a suite of climate/Earth system models developed at GFDL and other modeling centers. These models included typical CMIP5-class models, as well as the newer climate models GFDL CM2.5 and CM2.6 with eddying oceans. In response to the increase in greenhouse-gas concentrations, each of these models show a reduction in the AMOC. Given the observed connection between AMOC reduction and extreme coastal sea levels, the models thus project an increase in extreme SLR frequency on interannual time scales along the Northeast Coast of North America.

Percutaneous and Endoscopic Adhesiolysis in Managing Low Back and Lower Extremity Pain: A Systematic Review and Meta-analysis.

PubMed

Helm, Standiford; Racz, Gabor B; Gerdesmeyer, Ludger; Justiz, Rafael; Hayek, Salim M; Kaplan, Eugene D; El Terany, Mohamed Ahamed; Knezevic, Nebojsa Nick

2016-02-01

Chronic refractory low back and lower extremity pain is frustrating to treat. Percutaneous adhesiolysis and spinal endoscopy are techniques which can treat chronic refractory low back and lower extremity pain.Percutaneous adhesiolysis is performed by placing the catheter into the tissue plane at the ventrolateral aspect of the foramen so that medications can be injected. Adhesiolysis is used both for pain caused by scarring which is not resistant to catheter placement and other sources of pain, including inflammation in the absence of scarring.Mechanical lysis of scars with a catheter may or may not be necessary for percutaneous adhesiolysis to be effective. Spinal endoscopy allows direct visualization of the epidural space and has the possibility to use laser energy to treat pathology. A systematic review of the effectiveness of percutaneous adhesiolysis and spinal endoscopic adhesiolysis to treat chronic refractory low back and lower extremity pain. To evaluate and update the effectiveness of percutaneous adhesiolysis and spinal endoscopic adhesiolysis to treat chronic refractory low back and lower extremity pain. The available literature on percutaneous adhesiolysis and spinal endoscopic adhesiolysis in treating persistent low back and leg pain was reviewed. The quality of each article used in this analysis was assessed. The level of evidence was classified on a 5-point scale from strong, based upon multiple randomized controlled trials to weak, based upon consensus, as developed by the U.S. Preventive Services Task Force (USPSTF) and modified by ASIPP. Data sources included relevant literature identified through searches of PubMed and EMBASE from 1966 to September 2015, and manual searches of the bibliographies of known primary and review articles. Pain relief of at least 50% and functional improvement of at least 40% were the primary outcome measures. Short-term efficacy was defined as improvement of 6 months or less; whereas, long-term efficacy was defined more than 6 months. For this systematic review, 45 studies were identified. Of these, for percutaneous adhesiolysis there were 7 randomized controlled trials and 3 observational studies which met the inclusion criteria. For spinal endoscopy, there was one randomized controlled trial and 3 observational studies. Based upon 7 randomized controlled trials showing efficacy, with no negative trials, there is Level I or strong evidence of the efficacy of percutaneous adhesiolysis in the treatment of chronic refractory low back and lower extremity pain. Based upon one high-quality randomized controlled trial, there is Level II to III evidence supporting the use of spinal endoscopy in treating chronic refractory low back and lower extremity pain. The evidence is Level I or strong that percutaneous adhesiolysis is efficacious in the treatment of chronic refractory low back and lower extremity pain. Percutaneous adhesiolysis may be considered as a first-line treatment for chronic refractory low back and lower extremity pain. The evidence is Level II to III that spinal endoscopy is effective in the treatment of chronic refractory low back and lower extremity pain. Spinal pain, chronic low back pain, post lumbar surgery syndrome, epidural scarring, adhesiolysis, endoscopy, radicular pain.

Changes in the frequency of extreme air pollution events over the Eastern United States and Europe

NASA Astrophysics Data System (ADS)

Rieder, H. E.; Fiore, A. M.; Fang, Y.; Staehelin, J.

2011-12-01

Over the past few decades, thresholds for national air quality standards, intended to protect public health and welfare, have been lowered repeatedly. At the same time observations, over Europe and the Eastern U.S., demonstrate that extreme air pollution events (high O3 and PM2.5) are typically associated with stagnation events. Recent work showed that in a changing climate high air pollution events are likely to increase in frequency and duration. Within this work we examine meteorological and surface ozone observations from CASTNet over the U.S. and EMEP over Europe and "idealized" simulations with the GFDL AM3 chemistry-climate model, which isolate the role of climate change on air quality. Specifically, we examine an "idealized 1990s" simulation, forced with 20-year mean monthly climatologies for sea surface temperatures and sea ice from observations for 1981-2000, and an "idealized 2090s" simulation forced by the observed climatologies plus the multi-model mean changes in sea surface temperature and sea ice simulated by 19 IPCC AR-4 models under the A1B scenario for 2081-2100. With innovative statistical tools (empirical orthogonal functions (EOFs) and statistics of extremes (EVT)), we analyze the frequency distribution of past, present and future extreme air pollution events over the Eastern United States and Europe. The upper tail of observed values at individual stations (e.g., within the CASTNet), i.e., the extremes (maximum daily 8-hour average (MDA8) O3>60ppb) are poorly described by a Gaussian distribution. However, further analysis showed that applying Peak-Over-Threshold-models, better capture the extremes and allows us to estimate return levels of pollution events above certain threshold values of interest. We next apply EOF analysis to identify regions that vary coherently within the ground-based monitoring networks. Over the United States, the first EOF obtained from the model in both the 1990s and 2090s idealized simulations identifies the Northeast as a region that varies coherently. Correlation analysis reveals that this EOF pattern is most strongly expressed in association with high surface temperature and high surface pressure conditions, consistent with previous work showing that observed O3 episodes over this area reflect the combined impacts of stagnation and increased chemical production. Next steps include the extension of this analysis applying EVT tools to the principal component time series associated with this EOF. The combination of EOF and EVT tools applied to the GFDL AM3 1990s vs. 2090s idealized simulations will enable us to quantify changes in the return levels of air pollution extremes. Therefore the combination of observational data and numerical and statistical models should allow us to identify key driving forces between high air pollution events and to estimate changes in the frequency of such events under different climate change scenarios.

Binary-selectable detector holdoff circuit

NASA Technical Reports Server (NTRS)

Kadrmas, K. A.

1974-01-01

High-speed switching circuit protects detectors from sudden, extremely-intense backscattered radiation that results from short-range atmospheric dust layers, or low-level clouds, entering laser/radar field of view. Function of circuit is to provide computer-controlled switching of photodiode detector, preamplifier power-supply voltages, in approximately 10 nanoseconds.

Field effect transistors improve buffer amplifier

NASA Technical Reports Server (NTRS)

1967-01-01

Unity gain buffer amplifier with a Field Effect Transistor /FET/ differential input stage responds much faster than bipolar transistors when operated at low current levels. The circuit uses a dual FET in a unity gain buffer amplifier having extremely high input impedance, low bias current requirements, and wide bandwidth.

Manpower/Hardware Life Cycle Cost Analysis Study.

DTIC Science & Technology

1979-11-06

designer will begin to learn, on a subconscious level, about the likely outcome of tradeoffs. At the high rate of use expected for these machines, he...one requiring considerable cost analytic expertise), and the model must be redocumented and partially or completely reprogrammed . All this is extremely

Preparing for Extreme Heat in India: Using High-Resolution Climate Models to Explore the Impact of Rising Temperatures on Human Health and Labor Productivity

NASA Astrophysics Data System (ADS)

Shaw, C.

2016-12-01

Globally, higher daily peak temperatures and longer, more intense heat waves are becoming increasingly frequent due to climate change. India, with relatively low GDP per capita, high population density, and tropical climate, is particularly vulnerable to these trends. In May 2015, one of the worst heat waves in world history hit the country, culminating in at least 2,300 officially-reported deaths as temperatures in some regions reached 48°C. As a result of climate change, heat waves in this region will last longer, be more extreme, and occur with greater frequency in the coming years. Impacts will be felt most acutely by vulnerable populations, which include not only those with frail health, but also populations otherwise considered healthy whose livelihood involves working under exposure to high temperatures. The problem is exacerbated by low levels of economic development, particularly in the under-provision of medical services, a higher proportion of weather-reliant income sources, and the inability to recover quickly from shocks. Responding to these challenges requires collaboration among the disciplines of climate science, public health, economics, and public policy. This project, presented as an online web application using Esri's ArcGIS Story Map, covers 1) the impact of extreme heat on human mortality, 2) the impact of combined heat and humidity (as measured by wet bulb globe temperature) on labor productivity, and 3) emerging best practices in adaptation planning by local municipalities and NGOs. The work is presented in a format that is designed to allow policymakers to take a deeper dive into the literature linking extreme temperature to human health and labor productivity, combined with interactive mapping tools that allow planners to drill down to data at the district level across the country of India. Further, the work presents a case study of heat adaptation planning efforts that have already been implemented in the city of Ahmedabad, allowing planners to understand what adaptations options might be available to mitigate the risk. Taken together, the tool provides a means to stimulate adaptation efforts, helping society's ability to prepare and cope with extreme heat events.

Anti-citrullinated protein antibody-positive rheumatoid arthritis associated with RS3PE syndrome-like symptoms and an elevated serum vascular endothelial growth factor level in a patient with myasthenia gravis.

PubMed

Horai, Yoshiro; Honda, Mai; Nishino, Ayako; Nakashima, Yoshikazu; Suzuki, Takahisa; Kawashiri, Shin-Ya; Ichinose, Kunihiro; Tamai, Mami; Nakamura, Hideki; Motomura, Masakatsu; Origuchi, Tomoki; Kawakami, Atsushi

2014-01-01

A 73-year-old man with a history of myasthenia gravis (MG) was diagnosed with rheumatoid arthritis (RA) based on a history of polyarthritis and positivity for anti-citrullinated protein antibodies (ACPA). He presented with a high level of serum vascular endothelial growth factor (VEGF) and RS3PE syndrome-like pitting edema in the extremities, which improved following treatment with low-dose prednisolone. This is an interesting case of ACPA-positive RA associated with RS3PE syndrome-like pitting edema and a high VEGF level.

Perceived Gender Ratings for High and Low Scorers on the Autism-Spectrum Quotient Consistent with the Extreme Male Brain Account of Autism

PubMed Central

Simons, Jessica M.; Maybery, Murray T.; Leung, Doris; Ng, Honey L. H.; Whitehouse, Andrew J. O.

2015-01-01

The Extreme Male Brain (EMB) theory posits that autistic traits are linked to excessive exposure to testosterone in utero. While findings from a number of studies are consistent with this theory, other studies have produced contradictory results. For example, some findings suggest that rather than being linked to hypermasculinization for males, or defeminization for females, elevated levels of autistic traits are instead linked to more androgynous physical features. The current study provided further evidence relevant to the EMB and androgony positions by comparing groups of males selected for high or low scores on the Autism-spectrum Quotient (AQ) as to the rated masculinity of their faces and voices, and comparable groups of females as to the rated femininity of their faces and voices. The voices of High-AQ males were rated as more masculine than those of Low-AQ males, while the faces of High-AQ females were rated as less feminine than those of Low-AQ females. There was no effect of AQ group on femininity ratings for female voices or on masculinity ratings for male faces. The results thus provide partial support for a link between high levels of autistic-like traits and hypermasculinization for males and defeminization for females, consistent with the EMB theory. PMID:26186689

Influence of risk factors and past events on flood resilience in coastal megacities: Comparative analysis of NYC and Shanghai.

PubMed

Xian, Siyuan; Yin, Jie; Lin, Ning; Oppenheimer, Michael

2018-01-01

Coastal flood protection measures have been widely implemented to improve flood resilience. However, protection levels vary among coastal megacities globally. This study compares the distinct flood protection standards for two coastal megacities, New York City and Shanghai, and investigates potential influences such as risk factors and past flood events. Extreme value analysis reveals that, compared to NYC, Shanghai faces a significantly higher flood hazard. Flood inundation analysis indicates that Shanghai has a higher exposure to extreme flooding. Meanwhile, Shanghai's urban development, population, and economy have increased much faster than NYC's over the last three decades. These risk factors provide part of the explanation for the implementation of a relatively high level of protection (e.g. reinforced concrete sea-wall designed for a 200-year flood return level) in Shanghai and low protection (e.g. vertical brick and stone walls and sand dunes) in NYC. However, individual extreme flood events (typhoons in 1962, 1974, and 1981) seem to have had a greater impact on flood protection decision-making in Shanghai, while NYC responded significantly less to past events (with the exception of Hurricane Sandy). Climate change, sea level rise, and ongoing coastal development are rapidly changing the hazard and risk calculus for both cities and both would benefit from a more systematic and dynamic approach to coastal protection. Copyright © 2017 Elsevier B.V. All rights reserved.

The Influence of Recurrent Modes of Climate Variability on the Occurrence of Monthly Temperature Extremes Over South America

NASA Astrophysics Data System (ADS)

Loikith, Paul C.; Detzer, Judah; Mechoso, Carlos R.; Lee, Huikyo; Barkhordarian, Armineh

2017-10-01

The associations between extreme temperature months and four prominent modes of recurrent climate variability are examined over South America. Associations are computed as the percent of extreme temperature months concurrent with the upper and lower quartiles of the El Niño-Southern Oscillation (ENSO), the Atlantic Niño, the Pacific Decadal Oscillation (PDO), and the Southern Annular Mode (SAM) index distributions, stratified by season. The relationship is strongest for ENSO, with nearly every extreme temperature month concurrent with the upper or lower quartiles of its distribution in portions of northwestern South America during some seasons. The likelihood of extreme warm temperatures is enhanced over parts of northern South America when the Atlantic Niño index is in the upper quartile, while cold extremes are often association with the lowest quartile. Concurrent precipitation anomalies may contribute to these relations. The PDO shows weak associations during December, January, and February, while in June, July, and August its relationship with extreme warm temperatures closely matches that of ENSO. This may be due to the positive relationship between the PDO and ENSO, rather than the PDO acting as an independent physical mechanism. Over Patagonia, the SAM is highly influential during spring and fall, with warm and cold extremes being associated with positive and negative phases of the SAM, respectively. Composites of sea level pressure anomalies for extreme temperature months over Patagonia suggest an important role of local synoptic scale weather variability in addition to a favorable SAM for the occurrence of these extremes.

Climatic Extremes and Food Grain Production in India

NASA Astrophysics Data System (ADS)

A, A.; Mishra, V.

2015-12-01

Climate change is likely to affect food and water security in India. India has witnessed tremendous growth in its food production after the green revolution. However, during the recent decades the food grain yields were significantly affected by the extreme climate and weather events. Air temperature and associated extreme events (number of hot days and hot nights, heat waves) increased significantly during the last 50 years in the majority of India. More remarkably, a substantial increase in mean and extreme temperatures was observed during the winter season in India. On the other hand, India witnessed extreme flood and drought events that have become frequent during the past few decades. Extreme rainfall during the non-monsoon season adversely affected the food grain yields and results in tremendous losses in several parts of the country. Here we evaluate the changes in hydroclimatic extremes and its linkage with the food grain production in India. We use observed food grain yield data for the period of 1980-2012 at district level. We understand the linkages between food grain yield and crop phenology obtained from the high resolution leaf area index and NDVI datasets from satellites. We used long-term observed data of daily precipitation and maximum and minimum temperatures to evaluate changes in the extreme events. We use statistical models to develop relationships between crop yields, mean and extreme temperatures for various crops to understand the sensitivity of these crops towards changing climatic conditions. We find that some of the major crop types and predominant crop growing areas have shown a significant sensitivity towards changes in extreme climatic conditions in India.

Investigation of the 2006 Drought and 2007 Flood Extremes at the Southern Great Plains Through an Integrative Analysis of Observations

NASA Technical Reports Server (NTRS)

Dong, Xiquan; Xi, Baike; Kennedy, Aaron; Feng, Zhe; Entin, Jared K.; Houser, Paul R.; Schiffer, Robert A.; LEucyer, Tristan; Olson, William S.; Hsu, Kuo-lin;

Social networking among upper extremity patients.

PubMed

Rozental, Tamara D; George, Tina M; Chacko, Aron T

2010-05-01

Despite their rising popularity, the health care profession has been slow to embrace social networking sites. These are Web-based initiatives, designed to bring people with common interests or activities under a common umbrella. The purpose of this study is to evaluate social networking patterns among upper extremity patients. A total of 742 anonymous questionnaires were distributed among upper extremity outpatients, with a 62% response rate (462 were completed). Demographic characteristics (gender, age, level of education, employment, type of health insurance, and income stratification) were defined, and data on computer ownership and frequency of social networking use were collected. Social network users and nonusers were compared according to their demographic and socioeconomic characteristics. Our patient cohort consisted of 450 patients. Of those 450 patients, 418 had a high school education or higher, and 293 reported a college or graduate degree. The majority of patients (282) were employed at the time of the survey, and income was evenly distributed among U.S. Census Bureau quintiles. A total of 349 patients reported computer ownership, and 170 reported using social networking sites. When compared to nonusers, social networking users were younger (p<.001), more educated (p<.001), and more likely to be employed (p = .013). Users also had higher income levels (p=0.028) and had high rates of computer ownership (p<.001). Multivariate regression revealed that younger age (p<.001), computer ownership (p<.001), and higher education (p<.001) were independent predictors of social networking use. Most users (n = 114) regularly visit a single site. Facebook was the most popular site visited (n=142), followed by MySpace (n=28) and Twitter (n=16). Of the 450 upper extremity patients in our sample, 170 use social networking sites. Younger age, higher level of education, and computer ownership were associated with social networking use. Physicians should consider expanding their use of social networking sites to reach their online patient populations. Copyright 2010 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

The role of transcriptome resilience in resistance of corals to bleaching.

PubMed

Seneca, Francois O; Palumbi, Stephen R

2015-04-01

Wild populations increasingly experience extreme conditions as climate change amplifies environmental variability. How individuals respond to environmental extremes determines the impact of climate change overall. The variability of response from individual to individual can represent the opportunity for natural selection to occur as a result of extreme conditions. Here, we experimentally replicated the natural exposure to extreme temperatures of the reef lagoon at Ofu Island (American Samoa), where corals can experience severe heat stress during midday low tide. We investigated the bleaching and transcriptome response of 20 Acropora hyacinthus colonies 5 and 20 h after exposure to control (29 °C) or heated (35 °C) conditions. We found a highly dynamic transcriptome response: 27% of the coral transcriptome was significantly regulated 1 h postheat exposure. Yet 15 h later, when heat-induced coral bleaching became apparent, only 12% of the transcriptome was differentially regulated. A large proportion of responsive genes at the first time point returned to control levels, others remained differentially expressed over time, while an entirely different subset of genes was successively regulated at the second time point. However, a noteworthy variability in gene expression was observed among individual coral colonies. Among the genes of which expression lingered over time, fast return to normal levels was associated with low bleaching. Colonies that maintained higher expression levels of these genes bleached severely. Return to normal levels of gene expression after stress has been termed transcriptome resilience, and in the case of some specific genes may signal the physiological health and response ability of individuals to environmental stress. © 2015 John Wiley & Sons Ltd.

Glaucomatous Optic Neuropathy Associated with Nocturnal Dip in Blood Pressure: Findings from the Maracaibo Aging Study.

PubMed

Melgarejo, Jesús D; Lee, Joseph H; Petitto, Michele; Yépez, Juan B; Murati, Felipe A; Jin, Zhezhen; Chávez, Carlos A; Pirela, Rosa V; Calmón, Gustavo E; Lee, Winston; Johnson, Matthew P; Mena, Luis J; Al-Aswad, Lama A; Terwilliger, Joseph D; Allikmets, Rando; Maestre, Gladys E; De Moraes, C Gustavo

2018-06-01

To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics. Observational cross-sectional study. A subset (n = 93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants, who were at least 40 years of age, had measurements for optical tomography coherence, visual field (VF) tests, 24-hour BP, office BP, and intraocular pressure <22 mmHg. Univariate and multivariate logistic regression analyses under the generalized estimating equations (GEE) framework were used to examine the relationships between glaucomatous damage and BP parameters, with particular attention to decreases in nocturnal BP. Glaucomatous optic neuropathy (GON) based on the presence of optic nerve damage and VF defects. The mean age was 61.9 years, and 87.1% were women. Of 185 eyes evaluated, 19 (26.5%) had signs of GON. Individuals with GON had significantly lower 24-hour and nighttime diastolic BP levels than those without. However, results of the multivariate GEE models indicated that the glaucomatous damage was not related to the average systolic or diastolic BP levels measured over 24 hours, daytime, or nighttime. In contrast, extreme decreases in nighttime systolic and diastolic BP (>20% compared with daytime BP) were significant risk factors for glaucomatous damage (odds ratio, 19.78 and 5.55, respectively). In this population, the link between nocturnal BP and GON is determined by extreme dipping effects rather than low nocturnal BP levels alone. Further studies considering extreme decreases in nocturnal BP in individuals at high risk of glaucoma are warranted. Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Dismounted Complex Blast Injury.

PubMed

Andersen, Romney C; Fleming, Mark; Forsberg, Jonathan A; Gordon, Wade T; Nanos, George P; Charlton, Michael T; Ficke, James R

2012-01-01

The severe Dismounted Complex Blast Injury (DCBI) is characterized by high-energy injuries to the bilateral lower extremities (usually proximal transfemoral amputations) and/or upper extremity (usually involving the non-dominant side), in addition to open pelvic injuries, genitourinary, and abdominal trauma. Initial resuscitation and multidisciplinary surgical management appear to be the keys to survival. Definitive treatment follows general principals of open wound management and includes decontamination through aggressive and frequent debridement, hemorrhage control, viable tissue preservation, and appropriate timing of wound closure. These devastating injuries are associated with paradoxically favorable survival rates, but associated injuries and higher amputation levels lead to more difficult reconstructive challenges.

A Long Expected Party — The First Stone Ceremony for the Extremely Large Telescope

NASA Astrophysics Data System (ADS)

de Zeeuw, T.; Comerón, F.; Tamai, R.

2017-06-01

The ceremony to seal the time capsule, signalling the beginning of construction of the dome and main telescope structure for the Extremely Large Telescope, took place at the Paranal Observatory on 26 May 2017, in the presence of the President of Chile, Michelle Bachelet and many international guests. Owing to high winds, the ceremony could not take place as planned on the levelled site on Cerro Armazones, but instead was held at the Paranal Residencia. A brief report of the event and its organisation is presented, and the welcome speech by the ESO Director General is included.

Determination of radionuclides and radiochemical impurities produced by in-house cyclotron irradiation and subsequent radiosynthesis of PET tracers.

PubMed

Ishiwata, Kiichi; Hayashi, Kunpei; Sakai, Masanari; Kawauchi, Sugio; Hasegawa, Hideaki; Toyohara, Jun

2017-01-01

To elucidate the radionuclides and radiochemical impurities included in radiosynthesis processes of positron emission tomography (PET) tracers. Target materials and PET tracers were produced using a cyclotron/synthesis system from Sumitomo Heavy Industry. Positron and γ-ray emitting radionuclides were quantified by measuring radioactivity decay and using the high-purity Ge detector, respectively. Radiochemical species in gaseous and aqueous target materials were analyzed by gas and ion chromatography, respectively. Target materials had considerable levels of several positron emitters in addition to the positron of interest, and in the case of aqueous target materials extremely low levels of many γ-emitters. Five 11 C-, 15 O-, or 18 F-labeled tracers produced from gaseous materials via chemical reactions had no radionuclidic impurities, whereas 18 F-FDG, 18 F-NaF, and 13 N-NH 3 produced from aqueous materials had several γ-emitters as well as impure positron emitters. 15 O-Labeled CO 2 , O 2 , and CO had a radionuclidic impurity 13 N-N 2 (0.5-0.7 %). Target materials had several positron emitters other than the positron of interest, and extremely low level γ-emitters in the case of aqueous materials. PET tracers produced from gaseous materials except for 15 O-labeled gases had no impure radionuclides, whereas those derived from aqueous materials contained acceptable levels of impure positron emitters and extremely low levels of several γ-emitters.

Changes in Heart Rate Variability Recorded in Natural Situation with T-Shirt Integrated Sensors and Level of Observed Behavioral Excitation: A Pilot Study of Patients with Intellectual Disabilities and Psychiatric Disorders.

PubMed

Palix, Julie; Akselrod, Michel; Cungi, Charly; Giuliani, Fabienne; Favrod, Jérôme

2017-01-01

The present study investigates the possibilities of using heart rate variability (HRV) parameters as physiological markers that precede increase in observed behavioral excitation of intellectually disabled individuals. The ability to recognize or predict such patterns, especially in patients showing unpredictable reactions and language deficiencies, might be a major step forward in clinical research. Thirteen volunteers with intellectual disabilities, who had suffered of at least one event of overt aggression in the preceding 3 months, participated to the study. The protocol consists in the acquisition of continuous electrocardiogram (ECG) throughout approximately two times of 8 h in natural situation, using a T-shirt integrated with sensors. Simultaneously, an observer evaluates the patient's level of overt excitation from calm (level 1) to extremely tense (level 5) and send online via Bluetooth these triggers into the ECG signals. The HRV indexes were then estimated offline on the basis of the inter-beat intervals recorded by the ECG, independently for the 30 min preceding each behavioral tension marking point, averaged, and compared through non-parametric Wilcoxon matched-pairs test. Of these, the RMSSD and LF/HF calculations were used to observe the fluctuations of inhibitory activity and cardiovagal balance through different tension states. Seven individuals have sufficient reliable data for analysis. They have reached at least a level 3 of behavioral excitation (moderately tense) or more (very to extremely tense, level 4 and 5) and have been retained for further analysis. In sum, a total of 197 periods of tension were kept, made up of 46 periods of slight excitation (level 2), 18 of moderate excitation (level 3), 10 of high excitation (level 4), and 5 of extreme agitation (level 5). Variations in the HRV as a function of degree of excitation are observed for RMSSD index only (inhibitory parasympathetic activity). The changes from calm to increasing levels of excitation are characterized by a significant downfall in RMSSD index when patients were evaluated to be in a very high level of tension (level 4). The presence of precursors to agitation, reflected in the falling-off of parasympathetic activity, offers potentially interesting prospects for therapeutic development.

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.

PubMed

Dobrinas, Maria; Crettol, Séverine; Oneda, Beatrice; Lahyani, Rachel; Rotger, Margalida; Choong, Eva; Lubomirov, Rubin; Csajka, Chantal; Eap, Chin B

2013-02-01

(S)-Methadone, metabolized mainly by CYP2B6, shows a wide interindividual variability in its pharmacokinetics and pharmacodynamics. Resequencing of the CYP2B6 gene was performed in 12 and 35 selected individuals with high (S)-methadone plasma exposure and low (S)-methadone plasma exposure, respectively, from a previously described cohort of 276 patients undergoing methadone maintenance treatment. Selected genetic polymorphisms were then analyzed in the complete cohort. The rs35303484 (*11; c136A>G; M46V) polymorphism was overrepresented in the high (S)-methadone level group, whereas the rs3745274 (*9; c516G>T; Q172H), rs2279344 (c822+183G>A), and rs8192719 (c1294+53C>T) polymorphisms were underrepresented in the low (S)-methadone level group, suggesting an association with decreased CYP2B6 activity. Conversely, the rs3211371 (*5; c1459C>T; R487C) polymorphism was overrepresented in the low-level group, indicating an increased CYP2B6 activity. A higher allele frequency was found in the high-level group compared with the low-level group for rs3745274 (*9; c516G>T; Q172H), rs2279343 (*4; c785A>G; K262R) (together representing CYP2B6*6), rs8192719 (c1294+53C>T), and rs2279344 (c822+183G>A), suggesting their involvement in decreased CYP2B6 activity. These results should be replicated in larger independent cohorts. Known genetic polymorphisms in CYP2B6 contribute toward explaining extreme (S)-methadone plasma levels observed in a cohort of patients following methadone maintenance treatment.

400 Years of summer hydroclimate from stable isotopes in Iberian trees

NASA Astrophysics Data System (ADS)

Andreu-Hayles, Laia; Ummenhofer, Caroline C.; Barriendos, Mariano; Schleser, Gerhard H.; Helle, Gerhard; Leuenberger, Markus; Gutiérrez, Emilia; Cook, Edward R.

2017-07-01

Tree rings are natural archives that annually record distinct types of past climate variability depending on the parameters measured. Here, we use ring-width and stable isotopes in cellulose of trees from the northwestern Iberian Peninsula (IP) to understand regional summer hydroclimate over the last 400 years and the associated atmospheric patterns. Correlations between tree rings and climate data demonstrate that isotope signatures in the targeted Iberian pine forests are very sensitive to water availability during the summer period, and are mainly controlled by stomatal conductance. Non-linear methods based on extreme events analysis allow for capturing distinct seasonal climatic variability recorded by tree-ring parameters and asymmetric signals of the associated atmospheric features. Moreover, years with extreme high (low) values in the tree-ring records were characterised by coherent large-scale atmospheric circulation patterns with reduced (enhanced) moisture transport onto the northwestern IP. These analyses of extremes revealed that high/low proxy values do not necessarily correspond to mirror images in the atmospheric anomaly patterns, suggesting different drivers of these patterns and the corresponding signature recorded in the proxies. Regional hydroclimate features across the broader IP and western Europe during extreme wet/dry summers detected by the northwestern IP trees compare favourably to independent multicentury sea level pressure and drought reconstructions for Europe. Historical records also validate our findings that attribute non-linear moisture signals recorded by extreme tree-ring values to distinct large-scale atmospheric patterns and allow for 400-year reconstructions of the frequency of occurrence of extreme conditions in late spring and summer hydroclimate.

400 years of summer hydroclimate from stable isotopes in Iberian trees

NASA Astrophysics Data System (ADS)

Andreu-Hayles, Laia; Ummenhofer, Caroline C.; Barriendos, Mariano; Schleser, Gerhard H.; Helle, Gerhard; Leuenberger, Markus; Gutierrez, Emilia; Cook, Edward R.

2017-04-01

Tree rings are natural archives that annually record distinct types of past climate variability depending on the parameters measured. Here, we use ring-width and stable isotopes in cellulose of trees from the northwestern Iberian Peninsula (IP) to understand regional summer hydroclimate over the last 400 years and the associated atmospheric patterns. Correlations between tree rings and climate data demonstrate that isotope signatures in the targeted Iberian pine forests are very sensitive to water availability during the summer period, and are mainly controlled by stomatal conductance. Non-linear methods based on extreme events analysis allow for capturing distinct seasonal climatic variability recorded by tree-ring parameters and asymmetric signals of the associated atmospheric features. Moreover, years with extreme high (low) values in the tree-ring records were characterised by coherent large-scale atmospheric circulation patterns with reduced (enhanced) moisture transport onto the northwestern IP. These analyses of extremes revealed that high/low proxy values do not necessarily correspond to mirror images in the atmospheric anomaly patterns, suggesting different drivers of these patterns and the corresponding signature recorded in the proxies. Regional hydroclimate features across the broader IP and western Europe during extreme wet/dry summers detected by the northwestern IP trees compare favourably to an independent multicentury sea level pressure and drought reconstruction for Europe. Historical records also validate our findings that attribute non-linear moisture signals recorded by extreme tree-ring values to distinct large-scale atmospheric patterns and allow for 400-yr reconstructions of the frequency of occurrence of extreme conditions in summer hydroclimate. We will discuss how the results for Lillo compare with other records.

Evaluation of WRF-based convection-permitting multi-physics ensemble forecasts over China for an extreme rainfall event on 21 July 2012 in Beijing

NASA Astrophysics Data System (ADS)

Zhu, Kefeng; Xue, Ming

2016-11-01

On 21 July 2012, an extreme rainfall event that recorded a maximum rainfall amount over 24 hours of 460 mm, occurred in Beijing, China. Most operational models failed to predict such an extreme amount. In this study, a convective-permitting ensemble forecast system (CEFS), at 4-km grid spacing, covering the entire mainland of China, is applied to this extreme rainfall case. CEFS consists of 22 members and uses multiple physics parameterizations. For the event, the predicted maximum is 415 mm d-1 in the probability-matched ensemble mean. The predicted high-probability heavy rain region is located in southwest Beijing, as was observed. Ensemble-based verification scores are then investigated. For a small verification domain covering Beijing and its surrounding areas, the precipitation rank histogram of CEFS is much flatter than that of a reference global ensemble. CEFS has a lower (higher) Brier score and a higher resolution than the global ensemble for precipitation, indicating more reliable probabilistic forecasting by CEFS. Additionally, forecasts of different ensemble members are compared and discussed. Most of the extreme rainfall comes from convection in the warm sector east of an approaching cold front. A few members of CEFS successfully reproduce such precipitation, and orographic lift of highly moist low-level flows with a significantly southeasterly component is suggested to have played important roles in producing the initial convection. Comparisons between good and bad forecast members indicate a strong sensitivity of the extreme rainfall to the mesoscale environmental conditions, and, to less of an extent, the model physics.

Towards improved prediction and mitigation of beach overwash: Terrestrial LiDAR observation of dynamic beach berm erosion

NASA Astrophysics Data System (ADS)

Schubert, J. E.; Gallien, T.; Shakeri Majd, M.; Sanders, B. F.

2012-12-01

Globally, over 20 million people currently reside below high tide levels and 200 million are below storm tide levels. Future climate change along with the pressures of urbanization will exacerbate flooding in low lying coastal communities. In Southern California, coastal flooding is triggered by a combination of high tides, storm surge, and waves and recent research suggests that a current 100 year flood event may be experienced on a yearly basis by 2050 due to sea level rise adding a positive offset to return levels. Currently, Southern California coastal communities mitigate the threat of beach overwash, and consequent backshore flooding, with a combination of planning and operational activities such as protective beach berm construction. Theses berms consist of temporary alongshore sand dunes constructed days or hours before an extreme tide or wave event. Hydraulic modeling in urbanized embayments has shown that coastal flooding predictions are extremely sensitive to the presence of coastal protective infrastructure, requiring parameterization of the hard infrastructure elevations at centimetric accuracy. Beach berms are an example of temporary dynamic structures which undergo severe erosion during extreme events and are typically not included in flood risk assessment. Currently, little is known about the erosion process and performance of these structures, which adds uncertainty to flood hazard delineation and flood forecasts. To develop a deeper understanding of beach berm erosion dynamics, three trapezoidal shaped berms, approximately 35 m long and 1.5 m high, were constructed and failure during rising tide conditions was observed using terrestrial laser scanning. Concurrently, real-time kinematic GPS, high-definition time lapse photography, a local tide gauge and wave climate data were collected. The result is a rich and unique observational dataset capturing berm erosion dynamics. This poster highlights the data collected and presents methods for processing and leveraging multi-sensor field observation data. The data obtained from this study will be used to support the development and validation of a numerical beach berm overtopping and overwash model that will allow for improved predictions of coastal flood damage during winter storms and large swells.

Wind extremes in the North Sea basin under climate change: an ensemble study of 12 CMIP5 GCMs

NASA Astrophysics Data System (ADS)

de Winter, R.; Ruessink, G.; Sterl, A.

2012-12-01

Coastal safety may be influenced by climate change, as changes in extreme surge levels and wave extremes may increase the vulnerability of dunes and other coastal defenses. In the North Sea, an area already prone to severe flooding, these high surge levels and waves are generated by severe wind speeds during storm events. As a result of the geometry of the North Sea, not only the maximum wind speed is relevant, but also wind direction. Analyzing changes in a changing climate implies that several uncertainties need to be taken into account. First, there is the uncertainty in climate experiments, which represents the possible development of the emission of greenhouse gases. Second, there is uncertainty between the climate models that are used to analyze the effect of different climate experiments. The third uncertainty is the natural variability of the climate. When this system variability is large, small trends will be difficult to detect. The natural variability results in statistical uncertainty, especially for events with high return values. We addressed the first two types of uncertainties for extreme wind conditions in the North Sea using 12 CMIP5 GCMs. To evaluate the differences between the climate experiments, two climate experiments (rcp4.5 and rcp8.5) from 2050-2100 are compared with historical runs, running from 1950-2000. Rcp4.5 is considered to be a middle climate experiment and rcp8.5 represents high-end climate scenarios. The projections of the 12 GCMs for a given scenario illustrate model uncertainty. We focus on the North Sea basin, because changes in wind conditions could have a large impact on safety of the densely populated North Sea coast, an area that has already a high exposure to flooding. Our results show that, consistent with ERA-Interim results, the annual maximum wind speed in the historical run demonstrates large interannual variability. For the North Sea, the annual maximum wind speed is not projected to change in either rcp4.5 or rcp8.5. In fact, the differences in the 12 GCMs are larger than the difference between the three experiments. Furthermore, our results show that, the variation in direction of annual maximum wind speed is large and this precludes a firm statement on climate-change induced changes in these directions. Nonetheless, most models indicate a decrease in annual maximum wind speed from south-eastern directions and an increase from south-western and western directions. This might be caused by a poleward shift of the storm track. The amount of wind from north-west and north-north-west, wind directions that are responsible for the development of extreme storm surges in the southern part of the North Sea, are not projected to change. However, North Sea coasts that have the longest fetch for western direction, e.g. the German Bight, may encounter more often high storm surge levels and extreme waves when the annual maximum wind will indeed be more often from western direction.

Use of generalized population ratios to obtain Fe XV line intensities and linewidths at high electron densities

NASA Technical Reports Server (NTRS)

Kastner, S. O.; Bhatia, A. K.

1980-01-01

A generalized method for obtaining individual level population ratios is used to obtain relative intensities of extreme ultraviolet Fe XV emission lines in the range 284-500 A, which are density dependent for electron densities in the tokamak regime or higher. Four lines in particular are found to attain quite high intensities in the high-density limit. The same calculation provides inelastic contributions to linewidths. The method connects level populations and level widths through total probabilities t(ij), related to 'taboo' probabilities of Markov chain theory. The t(ij) are here evaluated for a real atomic system, being therefore of potential interest to random-walk theorists who have been limited to idealized systems characterized by simplified transition schemes.

Use of generalized population ratios to obtain Fe XV line intensities and linewidths at high electron densities

NASA Astrophysics Data System (ADS)

Kastner, S. O.; Bhatia, A. K.

1980-08-01

A generalized method for obtaining individual level population ratios is used to obtain relative intensities of extreme ultraviolet Fe XV emission lines in the range 284-500 A, which are density dependent for electron densities in the tokamak regime or higher. Four lines in particular are found to attain quite high intensities in the high-density limit. The same calculation provides inelastic contributions to linewidths. The method connects level populations and level widths through total probabilities t(ij), related to 'taboo' probabilities of Markov chain theory. The t(ij) are here evaluated for a real atomic system, being therefore of potential interest to random-walk theorists who have been limited to idealized systems characterized by simplified transition schemes.

Rasch Analysis of the Power as Knowing Participation in Change Tool--the Brazilian version.

PubMed

Guedes, Erika de Souza; Orozco-Vargas, Luiz Carlos; Turrini, Ruth Natália Teresa; de Sousa, Regina Márcia Cardoso; dos Santos, Mariana Alvina; da Cruz, Diná de Almeida Lopes Monteiro

2013-01-01

the objective of this study was to evaluate the items contained in the Brazilian version of the Power as Knowing Participation in Change Tool (PKPCT). investigation of the psychometric properties of the mentioned questionnaire through Rasch analysis. the data from 952 nursing assistants and 627 baccalaureate nurses were analyzed (average age 44.1 (SD=9.5); 13.0% men). The subscales Choices, Awareness, Freedom and Involvement were tested separately and presented unidimensionality; the categories of the responses given to the items were compiled from 7 to 3 levels and the items fit the model well, except for the following/leading item, in which the infit and outfit values were above 1.4; this item has also presented Differential Item Functioning (DIF) according to the participant's role. The reliability of the items was of 0.99 and the reliability of the participants ranged from 0.80 to 0.84 in the subscales. Items with extremely high levels of difficulty were not identified. the PKPCT should not be viewed as unidimensional, items with extremely high levels of difficulty in the scale need to be created and the differential functioning of some items has to be further investigated.

On the impact of fiber-delay-lines (FDL) in an all-optical network (AON) bottleneck without wavelength conversion

NASA Astrophysics Data System (ADS)

Argibay-Losada, Pablo Jesus; Sahin, Gokhan

2014-08-01

Random access memories (RAM) are fundamental in conventional electronic switches and routers to manage short-term congestion and to decrease data loss probabilities. Switches in all-optical networks (AONs), however, do not have access to optical RAM, and therefore are prone to much higher loss levels than their electronic counterparts. Fiber-delay-lines (FDLs), able to delay an optical data packet a fixed amount of time, have been proposed in the literature as a means to alleviate those high loss levels. However, they are extremely bulky to manage, so their usage introduces a trade-off between practicality and performance in the design and operation of the AON. In this paper we study the influence that FDLs have in the performance of flows crossing an all-optical switch that acts as their bottleneck. We show how extremely low numbers of FDLs (e.g., 1 or 2) can help in reducing losses by several orders of magnitude in several illustrative scenarios with high aggregation levels. Our results therefore suggest that FDLs can be a practical means of dealing with congestion in AONs in the absence of optical RAM buffers or of suitable data interchange protocols specifically designed for AONs.

Euro-Atlantic winter storminess and precipitation extremes under 1.5 °C vs. 2 °C warming scenarios

NASA Astrophysics Data System (ADS)

Barcikowska, Monika J.; Weaver, Scott J.; Feser, Frauke; Russo, Simone; Schenk, Frederik; Stone, Dáithí A.; Wehner, Michael F.; Zahn, Matthias

2018-06-01

Severe winter storms in combination with precipitation extremes pose a serious threat to Europe. Located at the southeastern exit of the North Atlantic's storm track, European coastlines are directly exposed to impacts by high wind speeds, storm floods and coastal erosion. In this study we analyze potential changes in simulated winter storminess and extreme precipitation, which may occur under 1.5 or 2 °C warming scenarios. Here we focus on a first simulation suite of the atmospheric model CAM5 performed within the HAPPI project and evaluate how changes of the horizontal model resolution impact the results regarding atmospheric pressure, storm tracks, wind speed and precipitation extremes. The comparison of CAM5 simulations with different resolutions indicates that an increased horizontal resolution to 0.25° not only refines regional-scale information but also improves large-scale atmospheric circulation features over the Euro-Atlantic region. The zonal bias in monthly pressure at mean sea level and wind fields, which is typically found in low-resolution models, is considerably reduced. This allows us to analyze potential changes in regional- to local-scale extreme wind speeds and precipitation in a more realistic way. Our analysis of the future response for the 2 °C warming scenario generally confirms previous model simulations suggesting a poleward shift and intensification of the meridional circulation in the Euro-Atlantic region. Additional analysis suggests that this shift occurs mainly after exceeding the 1.5 °C global warming level, when the midlatitude jet stream manifests a strengthening northeastward. At the same time, this northeastern shift of the storm tracks allows an intensification and northeastern expansion of the Azores high, leading to a tendency of less precipitation across the Bay of Biscay and North Sea. Regions impacted by the strengthening of the midlatitude jet, such as the northwestern coasts of the British Isles, Scandinavia and the Norwegian Sea, and over the North Atlantic east of Newfoundland, experience an increase in the mean as well as daily and sub-daily precipitation, wind extremes and storminess, suggesting an important influence of increasing storm activity in these regions in response to global warming.

An Examination of Extreme Fire Behavior and its Impact on Smoke Injection Altitude using Remote Sensing and Meteorological Data

NASA Astrophysics Data System (ADS)

Peterson, D. A.; Hyer, E. J.; Campbell, J. R.; Fromm, M. D.; Hair, J. W.; Butler, C. F.; Fenn, M. A.

2014-12-01

A variety of regional smoke forecasting applications are currently available to identify air quality, visibility, and societal impacts during large fire events. However, these systems typically assume persistent fire activity, and therefore can have large errors before, during, and after short-term periods of extreme fire behavior. This study employs a wide variety of ground, airborne, and satellite observations, including data collected during a major NASA airborne and field campaign, to examine the conditions required for both extreme spread and pyrocumulonimbus (pyroCb) development. Results highlight the importance of upper-level and nocturnal meteorology, as well as the limitations of traditional fire weather indices. Increasing values of fire radiative power (FRP) at the pixel and sub-pixel level are shown to systematically correspond to higher altitude smoke plumes, and an increased probability of injection above the boundary layer. Lidar data collected during the 2013 Rim Fire, one of the most severe fire events in California's history, show that high FRP observed during extreme spread can facilitate long-distance smoke transport, but fails to loft smoke to the altitude of a large pyroCb. The most extreme fire spread was also observed on days without pyroCb activity or significant regional convection. By incorporating additional fire events across North America, conflicting hypotheses surrounding the primary source of moisture during pyroCb development are examined. The majority of large pyroCbs, and therefore the highest direct injection altitude of smoke particles, is shown to occur with conditions very similar to those that produce dry thunderstorms. The current suite of automated forecasting applications predict only general trends in fire behavior, and specifically do not predict (1) extreme fire spread events and (2) injection of smoke to high altitudes. While (1) and (2) are related, results show that they are not predicted by the same set of conditions and variables. The combination of meteorology from numerical forecast models and satellite observations exhibits great potential for improving regional forecasts of fire behavior and smoke production in automated systems, especially in remote areas where detailed observations are unavailable

The effect of extreme spring weather on body condition and stress physiology in Lapland longspurs and white-crowned sparrows breeding in the Arctic.

PubMed

Krause, Jesse S; Pérez, Jonathan H; Chmura, Helen E; Sweet, Shannan K; Meddle, Simone L; Hunt, Kathleen E; Gough, Laura; Boelman, Natalie; Wingfield, John C

2016-10-01

Climate change is causing rapid shifts in temperature while also increasing the frequency, duration, and intensity of extreme weather. In the northern hemisphere, the spring of 2013 was characterized as extreme due to record high snow cover and low temperatures. Studies that describe the effects of extreme weather on phenology across taxa are limited while morphological and physiological responses remain poorly understood. Stress physiology, as measured through baseline and stress-induced concentrations of cortisol or corticosterone, has often been studied to understand how organisms respond to environmental stressors. We compared body condition and stress physiology of two long-distance migrants breeding in low arctic Alaska - the white-crowned sparrow (Zonotrichia leucophrys) and Lapland longspur (Calcarius lapponicus) - in 2013, an extreme weather year, with three more typical years (2011, 2012, and 2014). The extended snow cover in spring 2013 caused measureable changes in phenology, body condition and physiology. Arrival timing for both species was delayed 4-5days compared to the other three years. Lapland longspurs had reduced fat stores, pectoralis muscle profiles, body mass, and hematocrit levels, while stress-induced concentrations of corticosterone were increased. Similarly, white-crowned sparrows had reduced pectoralis muscle profiles and hematocrit levels, but in contrast to Lapland longspurs, had elevated fat stores and no difference in mass or stress physiology relative to other study years. An understanding of physiological mechanisms that regulate coping strategies is of critical importance for predicting how species will respond to the occurrence of extreme events in the future due to global climate change. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Within-summer variation in out-of-hospital cardiac arrest due to extremely long sunshine duration.

PubMed

Onozuka, Daisuke; Hagihara, Akihito

2017-03-15

Although several studies have reported the impacts of extremely high temperatures on cardiovascular diseases, no studies have examined whether variation in out-of-hospital cardiac arrest (OHCA) due to extremely long sunshine duration changes during the summer. We obtained daily data on all cases of OHCA and weather variations for all 47 prefectures of Japan during the summer (June to September) between 2005 and 2014. A distributed lag non-linear model combined with a quasi-Poisson regression model was used to estimate within-summer variation in OHCA due to extremely long sunshine duration for each prefecture. Then, multivariate random-effects meta-analysis was performed to derive overall effect estimates of sunshine duration at the national level. A total of 166,496 OHCAs of presumed cardiac origin met the inclusion criteria. The minimum morbidity percentile (MMP) was the 0th percentile of sunshine duration at the national level. The overall cumulative relative risk (RR) at the 99th percentile vs. the MMP was 1.15 (95% CI: 1.05-1.27) during the summer. The effect of extremely long sunshine duration on OHCA in early summer was acute and did not persist, whereas an identical effect was observed in late summer, but it was delayed and lasted for several days. During summer periods, excessive sunshine duration could increase the risk of OHCA. Timely preventive measures to reduce the OHCA risk due to extremely long sunshine duration are important in early summer, whereas these measures could include a wider time window of several days to reduce the risk in late summer. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

An extreme dust storm over the Arabian Peninsula in Spring 2015: the role of convective mixing and vortex stretching

NASA Astrophysics Data System (ADS)

Hauser, Seraphine; Pante, Gregor; Pantillon, Florian; Knippertz, Peter

2017-04-01

The Arabian Peninsula is one of the World's largest dust sources. Severe dust storms occur throughout the year dominated by synoptic-scale driven frontal systems in winter and spring and convective systems during summer and autumn. Dust storm frequency peaks in spring, when extra-tropical upper-level troughs associated with near-surface cold fronts regularly penetrate into the peninsula. In this study we investigate the dynamics of an extreme springtime dust event, which covered the entire Arabian Peninsula and the adjacent Indian Ocean in early April 2015. In addition to the more common trough/frontal characteristics, EUMETSAT's false-colour dust product shows a striking vortex-like structure during the initial state of the storm. Several SYNOP stations on the Arabian Peninsula report severe dust storms, rapid temperature drop, strong increase in wind speed up to 40 kn and zero visibility for several hours on 01 and 02 April. Remarkably also, 61 mm of rainfall are observed on 01 April at the station Arar in northern Saudi Arabia (annual average 52 mm), clearly indicating a convective contribution to this event. Some evidence for significant precipitation is also found in satellite products. Operational analyses of the European Centre for Medium-Range Weather Forecasts (ECMWF) show a distinct short-wave upper-level trough swiftly propagating across the region during this period, accompanied by high relative vorticity values of up to 10 times the planetary vorticity. This vorticity is associated with the trough's curvature, but also with the large cyclonic shear at the northern side of the subtropical jet. The passage of the upper-level disturbance is well timed to overpass the region of the Arabian Peninsula heat low around midday, where vorticity is thermally generated. Most likely the deep boundary layer facilitated the triggering of convection by the upper-level forcing. Ultimately, downward mixing of the high vorticity by convection plus vortex stretching cause exceptionally high vorticity near the surface, which initiated this extreme and unusual dust storm. Short-range ECMWF forecasts produce precipitation but not as extreme as measured at Arar. The model also generates strong near-surface winds, which are generally in good agreement with the SYNOP observations. Interestingly, however, the 10 m wind direction falls short to reflect the extreme cyclonic curvature evident in station observations, pointing to an underestimation of the vortex in the model. We hypothesise that the ECMWF model with its parameterised convection is unable to realistically represent the vertical mixing and vortex stretching. Numerical simulations on the convection permitting scale might improve forecasts of such events, but this is yet to be tested.

The influence of tree stands and a noise barrier on near-roadway air quality

EPA Science Inventory

Prediction of air pollution exposure levels of people living near or commuting on roadways is still very problematic due to the highly localized nature of traffic intensity, fleet composition, and extremely complex air flow patterns in urban areas. Both modelling and field studie...

Acculturation, Stressors, and Somatization Patterns among Students from Extreme South Texas.

ERIC Educational Resources Information Center

Montgomery, Gary T.

1992-01-01

Cervantes and Castro's model proposes that acculturation level functions both as external stressor and internal mediator influencing one's appraisal of environmental stressors and somatic/health outcomes. The model was supported by surveys of headache causes, severity, symptoms, and coping strategies among 844 Mexican-American high school and…

Development of Perceptual Expertise in Emotion Recognition

ERIC Educational Resources Information Center

Pollak, Seth D.; Messner, Michael; Kistler, Doris J.; Cohn, Jeffrey F.

2009-01-01

How do children's early social experiences influence their perception of emotion-specific information communicated by the face? To examine this question, we tested a group of abused children who had been exposed to extremely high levels of parental anger expression and physical threat. Children were presented with arrays of stimuli that depicted…

Understanding the Impacts of Climate and Hydrologic Extremes on Diarrheal Diseases in Southwestern Amazon

NASA Astrophysics Data System (ADS)

Fonseca, P. A. M.

2015-12-01

Bacterial diarrheal diseases have a high incidence rate during and after flooding episodes. In the Brazilian Amazon, flood extreme events have become more frequent, leading to high incidence rates for infant diarrhea. In this study we aimed to find a statistical association between rainfall, river levels and diarrheal diseases in children under 5, in the river Acre basin, in the State of Acre (Brazil). We also aimed to identify the time-lag and annual season of extreme rainfall and flooding in different cities in the water basin. The results using Tropical Rainfall Measuring Mission (TRMM) Satellite rainfall data show robustness of these estimates against observational stations on-ground. The Pearson coefficient correlation results (highest 0.35) indicate a time-lag, up to 4 days in three of the cities in the water-basin. In addition, a correlation was also tested between monthly accumulated rainfall and the diarrheal incidence during the rainy season (DJF). Correlation results were higher, especially in Acrelândia (0.7) and Brasiléia and Epitaciolândia (0.5). The correlation between water level monthly averages and diarrheal diseases incidence was 0.3 and 0.5 in Brasiléia and Epitaciolândia. The time-lag evidence found in this paper is critical to inform stakeholders, local populations and civil defense authorities about the time available for preventive and adaptation measures between extreme rainfall and flooding events in vulnerable cities. This study was part of a pilot application in the state of Acre of the PULSE-Brazil project (http://www.pulse-brasil.org/tool/), an interface of climate, environmental and health data to support climate adaptation. The next step of this research is to expand the analysis to other climate variables on diarrheal diseases across the whole Brazilian Amazon Basin and estimate the relative risk (RR) of a child getting sick. A statistical model will estimate RR based on the observed values and seasonal forecasts (higher accuracy for the Amazon region) will be used so the government can be prepared for extreme climate events forecasted. It is expected that these results can be helpful during and post extreme events to improve health surveillance preparedness and better allocate available results in adapting vulnerable cities to climate extreme events.

A case of severe anorexia, excessive weight loss and high peptide YY levels after sleeve gastrectomy.

PubMed

Pucci, Andrea; Cheung, Wui Hang; Jones, Jenny; Manning, Sean; Kingett, Helen; Adamo, Marco; Elkalaawy, Mohamed; Jenkinson, Andrew; Finer, Nicholas; Doyle, Jacqueline; Hashemi, Majid; Batterham, Rachel L

2015-01-01

Sleeve gastrectomy (SG) is the second most commonly performed bariatric procedure worldwide. Altered circulating gut hormones have been suggested to contribute post-operatively to appetite suppression, decreased caloric intake and weight reduction. In the present study, we report a 22-year-old woman who underwent laparoscopic SG for obesity (BMI 46 kg/m(2)). Post-operatively, she reported marked appetite reduction, which resulted in excessive weight loss (1-year post-SG: BMI 22 kg/m(2), weight loss 52%, >99th centile of 1-year percentage of weight loss from 453 SG patients). Gastrointestinal (GI) imaging, GI physiology/motility studies and endoscopy revealed no anatomical cause for her symptoms, and psychological assessments excluded an eating disorder. Despite nutritional supplements and anti-emetics, her weight loss continued (BMI 19 kg/m(2)), and she required nasogastric feeding. A random gut hormone assessment revealed high plasma peptide YY (PYY) levels. She underwent a 3 h meal study following an overnight fast to assess her subjective appetite and circulating gut hormone levels. Her fasted nausea scores were high, with low hunger, and these worsened with nutrient ingestion. Compared to ten other post-SG female patients, her fasted circulating PYY and nutrient-stimulated PYY and active glucagon-like peptide 1 (GLP1) levels were markedly elevated. Octreotide treatment was associated with suppressed circulating PYY and GLP1 levels, increased appetite, increased caloric intake and weight gain (BMI 22 kg/m(2) after 6 months). The present case highlights the value of measuring gut hormones in patients following bariatric surgery who present with anorexia and excessive weight loss and suggests that octreotide treatment can produce symptomatic relief and weight regain in this setting. Roux-en-Y gastric bypass and SG produce marked sustained weight reduction. However, there is a marked individual variability in this reduction, and post-operative weight loss follows a normal distribution with extremes of 'good' and 'poor' response.Profound anorexia and excessive weight loss post-SG may be associated with markedly elevated circulating fasted PYY and post-meal PYY and GLP1 levels.Octreotide treatment can produce symptomatic relief and weight regain for post-SG patients that have an extreme anorectic and weight loss response.The present case highlights the value of measuring circulating gut hormone levels in patients with post-operative anorexia and extreme weight loss.

Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations.

PubMed

Kim, Dae-Hyeong; Song, Jizhou; Choi, Won Mook; Kim, Hoon-Sik; Kim, Rak-Hwan; Liu, Zhuangjian; Huang, Yonggang Y; Hwang, Keh-Chih; Zhang, Yong-wei; Rogers, John A

2008-12-02

Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable new biomedical devices and other applications whose requirements are impossible to satisfy with conventional wafer-based technologies or even with those that offer simple bendability. This article introduces materials and mechanical design strategies for classes of electronic circuits that offer extremely high stretchability, enabling them to accommodate even demanding configurations such as corkscrew twists with tight pitch (e.g., 90 degrees in approximately 1 cm) and linear stretching to "rubber-band" levels of strain (e.g., up to approximately 140%). The use of single crystalline silicon nanomaterials for the semiconductor provides performance in stretchable complementary metal-oxide-semiconductor (CMOS) integrated circuits approaching that of conventional devices with comparable feature sizes formed on silicon wafers. Comprehensive theoretical studies of the mechanics reveal the way in which the structural designs enable these extreme mechanical properties without fracturing the intrinsically brittle active materials or even inducing significant changes in their electrical properties. The results, as demonstrated through electrical measurements of arrays of transistors, CMOS inverters, ring oscillators, and differential amplifiers, suggest a valuable route to high-performance stretchable electronics.

Subsurface geomicrobiology of the Iberian Pyritic Belt, a terrestrial analogue of Mars

NASA Astrophysics Data System (ADS)

Amils, Ricardo

Terrestrial subsurface geomicrobiology is a matter of growing interest on many levels. From a fundamental point of view, it seeks to determine whether life can be sustained in the absence of radiation. From an astrobiological point of view, it is an interesting model for early life on Earth, as well as a representation of life as it could occur in other planetary bodies, e.g., Mars. Ŕ Tinto is an unusual extreme acidic environment due to its size, constant acidic pH, high ıo concentration of heavy metals and high level of microbial diversity. Ŕ Tinto rises in the core of ıo the Iberian Pyritic Belt (IPB), one of the biggest sulfidic ore deposits in the world. Today it is clear that the extreme characteristics of Ŕ Tinto are not due to acid mine drainage resulting ıo from mining activity. To explore the hypothesis that a continuous underground reactor of chemolithotrophic microorganisms thriving in the rich sulfidic minerals of the IPB is responsible for the extreme conditions found in the river, a drilling project has been developed to detect evidence of subsurface microbial activity and potential resources to support these microbial communities in situ from retrieved cores (MARTE project). Preliminary results clearly show that there is an active subsurface geomicrobiology in the Iberian Pyritic Belt associated to places were ground waters intersects the sulfidic ore body.

Accuracy of Handheld Blood Glucose Meters at High Altitude

PubMed Central

de Vries, Suzanna T.; Fokkert, Marion J.; Dikkeschei, Bert D.; Rienks, Rienk; Bilo, Karin M.; Bilo, Henk J. G.

2010-01-01

Background Due to increasing numbers of people with diabetes taking part in extreme sports (e.g., high-altitude trekking), reliable handheld blood glucose meters (BGMs) are necessary. Accurate blood glucose measurement under extreme conditions is paramount for safe recreation at altitude. Prior studies reported bias in blood glucose measurements using different BGMs at high altitude. We hypothesized that glucose-oxidase based BGMs are more influenced by the lower atmospheric oxygen pressure at altitude than glucose dehydrogenase based BGMs. Methodology/Principal Findings Glucose measurements at simulated altitude of nine BGMs (six glucose dehydrogenase and three glucose oxidase BGMs) were compared to glucose measurement on a similar BGM at sea level and to a laboratory glucose reference method. Venous blood samples of four different glucose levels were used. Moreover, two glucose oxidase and two glucose dehydrogenase based BGMs were evaluated at different altitudes on Mount Kilimanjaro. Accuracy criteria were set at a bias <15% from reference glucose (when >6.5 mmol/L) and <1 mmol/L from reference glucose (when <6.5 mmol/L). No significant difference was observed between measurements at simulated altitude and sea level for either glucose oxidase based BGMs or glucose dehydrogenase based BGMs as a group phenomenon. Two GDH based BGMs did not meet set performance criteria. Most BGMs are generally overestimating true glucose concentration at high altitude. Conclusion At simulated high altitude all tested BGMs, including glucose oxidase based BGMs, did not show influence of low atmospheric oxygen pressure. All BGMs, except for two GDH based BGMs, performed within predefined criteria. At true high altitude one GDH based BGM had best precision and accuracy. PMID:21103399

High current density ion beam obtained by a transition to a highly focused state in extremely low-energy region.

PubMed

Hirano, Y; Kiyama, S; Fujiwara, Y; Koguchi, H; Sakakita, H

2015-11-01

A high current density (≈3 mA/cm(2)) hydrogen ion beam source operating in an extremely low-energy region (E(ib) ≈ 150-200 eV) has been realized by using a transition to a highly focused state, where the beam is extracted from the ion source chamber through three concave electrodes with nominal focal lengths of ≈350 mm. The transition occurs when the beam energy exceeds a threshold value between 145 and 170 eV. Low-level hysteresis is observed in the transition when E(ib) is being reduced. The radial profiles of the ion beam current density and the low temperature ion current density can be obtained separately using a Faraday cup with a grid in front. The measured profiles confirm that more than a half of the extracted beam ions reaches the target plate with a good focusing profile with a full width at half maximum of ≈3 cm. Estimation of the particle balances in beam ions, the slow ions, and the electrons indicates the possibility that the secondary electron emission from the target plate and electron impact ionization of hydrogen may play roles as particle sources in this extremely low-energy beam after the compensation of beam ion space charge.

Plant tolerance to high temperature in a changing environment: scientific fundamentals and production of heat stress-tolerant crops

PubMed Central

Bita, Craita E.; Gerats, Tom

2013-01-01

Global warming is predicted to have a general negative effect on plant growth due to the damaging effect of high temperatures on plant development. The increasing threat of climatological extremes including very high temperatures might lead to catastrophic loss of crop productivity and result in wide spread famine. In this review, we assess the impact of global climate change on the agricultural crop production. There is a differential effect of climate change both in terms of geographic location and the crops that will likely show the most extreme reductions in yield as a result of expected extreme fluctuations in temperature and global warming in general. High temperature stress has a wide range of effects on plants in terms of physiology, biochemistry and gene regulation pathways. However, strategies exist to crop improvement for heat stress tolerance. In this review, we present recent advances of research on all these levels of investigation and focus on potential leads that may help to understand more fully the mechanisms that make plants tolerant or susceptible to heat stress. Finally, we review possible procedures and methods which could lead to the generation of new varieties with sustainable yield production, in a world likely to be challenged both by increasing population, higher average temperatures and larger temperature fluctuations. PMID:23914193

Plant tolerance to high temperature in a changing environment: scientific fundamentals and production of heat stress-tolerant crops.

PubMed

Bita, Craita E; Gerats, Tom

2013-01-01

Global warming is predicted to have a general negative effect on plant growth due to the damaging effect of high temperatures on plant development. The increasing threat of climatological extremes including very high temperatures might lead to catastrophic loss of crop productivity and result in wide spread famine. In this review, we assess the impact of global climate change on the agricultural crop production. There is a differential effect of climate change both in terms of geographic location and the crops that will likely show the most extreme reductions in yield as a result of expected extreme fluctuations in temperature and global warming in general. High temperature stress has a wide range of effects on plants in terms of physiology, biochemistry and gene regulation pathways. However, strategies exist to crop improvement for heat stress tolerance. In this review, we present recent advances of research on all these levels of investigation and focus on potential leads that may help to understand more fully the mechanisms that make plants tolerant or susceptible to heat stress. Finally, we review possible procedures and methods which could lead to the generation of new varieties with sustainable yield production, in a world likely to be challenged both by increasing population, higher average temperatures and larger temperature fluctuations.

An extreme event of sea-level rise along the Northeast Coast of North America in 2009-2010.

PubMed

Goddard, Paul B; Yin, Jianjun; Griffies, Stephen M; Zhang, Shaoqing

2015-02-24

The coastal sea levels along the Northeast Coast of North America show significant year-to-year fluctuations in a general upward trend. The analysis of long-term tide gauge records identified an extreme sea-level rise (SLR) event during 2009-10. Within this 2-year period, the coastal sea level north of New York City jumped by 128 mm. This magnitude of interannual SLR is unprecedented (a 1-in-850 year event) during the entire history of the tide gauge records. Here we show that this extreme SLR event is a combined effect of two factors: an observed 30% downturn of the Atlantic meridional overturning circulation during 2009-10, and a significant negative North Atlantic Oscillation index. The extreme nature of the 2009-10 SLR event suggests that such a significant downturn of the Atlantic overturning circulation is very unusual. During the twenty-first century, climate models project an increase in magnitude and frequency of extreme interannual SLR events along this densely populated coast.

Relationship between lower extremity isometric muscle strength and standing balance in patients with multiple sclerosis.

PubMed

Citaker, Seyit; Guclu-Gunduz, Arzu; Yazici, Gokhan; Bayraktar, Deniz; Nazliel, Bijen; Irkec, Ceyla

2013-01-01

Muscle strength and standing balance decrease in patients with Multiple Sclerosis (MS). The aim of the present study was to investigate the relationship between the lower extremity isometric muscle strength and standing balance in patients with MS. Forty-seven patients with MS and 10 healthy volunteers were included. Neurological disability level was assessed using Expanded Disability Status Scale (EDSS). Isometric strength of seven lower extremity muscles (hip flexor-extensor-abductor-adductor, knee flexor-extensor, and ankle dorsal flexor) was assessed using hand-held dynamometer. Duration of static one-leg standing balance was measured using digital chronometer. Hip flexor-extensor-abductor-adductor, knee flexor-extensor, and ankle dorsal flexor isometric muscle strength, and duration of one-leg standing balance were decreased in patients with MS when compared with controls (p < 0.05). All assessed lower extremity isometric muscle strength and EDSS level was related duration of one-leg standing balance in patients with MS. All assessed lower extremity isometric muscle strength (except ankle dorsal flexor) was related with EDSS. Hip flexor-extensor-abductor-adductor, knee flexor-extensor, and ankle dorsal flexor isometric muscle strength decreases in ambulatory MS patients. Lower extremity muscle weakness and neurological disability level are related with imbalance in MS population. Hip and knee region muscles weakness increases the neurological disability level. For the better balance and decrease neurological disability level whole lower extremity muscle strengthening should be included in rehabilitation programs.

Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels-The zero-LDL hypothesis.

PubMed

Masana, Luis; Girona, Josefa; Ibarretxe, Daiana; Rodríguez-Calvo, Ricardo; Rosales, Roser; Vallvé, Joan-Carles; Rodríguez-Borjabad, Cèlia; Guardiola, Montserrat; Rodríguez, Marina; Guaita-Esteruelas, Sandra; Oliva, Iris; Martínez-Micaelo, Neus; Heras, Mercedes; Ferré, Raimon; Ribalta, Josep; Plana, Núria

While the impact of very low concentrations of low-density lipoprotein cholesterol (LDL-C) on cardiovascular prevention is very reassuring, it is intriguing to know what effect these extremely low LDL-C concentrations have on lipid homoeostasis. The evidence supporting the safety of extremely low LDL levels comes from genetic studies and clinical drug trials. Individuals with lifelong low LDL levels due to mutations in genes associated with increased LDL-LDL receptor (LDLR) activity reveal no safety issues. Patients achieving extremely low LDL levels in the IMPROVE-IT and FOURIER, and the PROFICIO and ODYSSEY programs seem not to have an increased prevalence of adverse effects. The main concern regarding extremely low LDL-C plasma concentrations is the adequacy of the supply of cholesterol, and other molecules, to peripheral tissues. However, LDL proteomic and kinetic studies reaffirm that LDL is the final product of endogenous lipoprotein metabolism. Four of 5 LDL particles are cleared through the LDL-LDLR pathway in the liver. Given that mammalian cells have no enzymatic systems to degrade cholesterol, the LDL-LDLR pathway is the main mechanism for removal of cholesterol from the body. Our focus, therefore, is to review, from a physiological perspective, why such extremely low LDL-C concentrations do not appear to be detrimental. We suggest that extremely low LDL-C levels due to increased LDLR activity may be a surrogate of adequate LDL-LDLR pathway function. Copyright © 2018 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Sensitive Multi-Species Emissions Monitoring: Infrared Laser-Based Detection of Trace-Level Contaminants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steill, Jeffrey D.; Huang, Haifeng; Hoops, Alexandra A.

This report summarizes our development of spectroscopic chemical analysis techniques and spectral modeling for trace-gas measurements of highly-regulated low-concentration species present in flue gas emissions from utility coal boilers such as HCl under conditions of high humidity. Detailed spectral modeling of the spectroscopy of HCl and other important combustion and atmospheric species such as H 2 O, CO 2 , N 2 O, NO 2 , SO 2 , and CH 4 demonstrates that IR-laser spectroscopy is a sensitive multi-component analysis strategy. Experimental measurements from techniques based on IR laser spectroscopy are presented that demonstrate sub-ppm sensitivity levels to thesemore » species. Photoacoustic infrared spectroscopy is used to detect and quantify HCl at ppm levels with extremely high signal-to-noise even under conditions of high relative humidity. Additionally, cavity ring-down IR spectroscopy is used to achieve an extremely high sensitivity to combustion trace gases in this spectral region; ppm level CH 4 is one demonstrated example. The importance of spectral resolution in the sensitivity of a trace-gas measurement is examined by spectral modeling in the mid- and near-IR, and efforts to improve measurement resolution through novel instrument development are described. While previous project reports focused on benefits and complexities of the dual-etalon cavity ring-down infrared spectrometer, here details on steps taken to implement this unique and potentially revolutionary instrument are described. This report also illustrates and critiques the general strategy of IR- laser photodetection of trace gases leading to the conclusion that mid-IR laser spectroscopy techniques provide a promising basis for further instrument development and implementation that will enable cost-effective sensitive detection of multiple key contaminant species simultaneously.« less

Ni-base superalloy powder-processed porous layer for gas cooling in extreme environments

DOE PAGES

White, Emma M. H.; Heidloff, Andrew J.; Byrd, David J.; ...

2016-05-26

Extreme high temperature conditions demand novel solutions for hot gas filters and coolant access architectures, i.e., porous layers on exposed components. These high temperatures, for example in current turbine engines, are at or exceeding current material limits for high temperature oxidation/corrosion, creep resistance, and, even, melting temperature. Thus novel blade designs allowing greater heat removal are required to maintain airfoil temperatures below melting and/ or rapid creep deformation limits. Gas atomized Ni-base superalloy powders were partially sintered into porous layers to allow full-surface, transpirational cooling of the surface of airfoils. Furthermore, these powder-processed porous layers were fully characterized for surface,more » morphology, cross-sectional microstructure, and mechanical strength characteristics. A sintering model based on pure Ni surface diffusion correlated well with the experimental results and allowed reasonable control over the partial sintering process to obtain a specified level of porosity within the porous layer.« less

Feasibility of High-Repetition, Task-Specific Training for Individuals With Upper-Extremity Paresis

PubMed Central

Waddell, Kimberly J.; Birkenmeier, Rebecca L.; Moore, Jennifer L.; Hornby, T. George

2014-01-01

OBJECTIVE. We investigated the feasibility of delivering an individualized, progressive, high-repetition upper-extremity (UE) task-specific training protocol for people with stroke in the inpatient rehabilitation setting. METHOD. Fifteen patients with UE paresis participated in this study. Task-specific UE training was scheduled for 60 min/day, 4 days/wk, during occupational therapy for the duration of a participant’s inpatient stay. During each session, participants were challenged to complete ≥300 repetitions of various tasks. RESULTS. Participants averaged 289 repetitions/session, spending 47 of 60 min in active training. Participants improved on impairment and activity level outcome measures. CONCLUSION. People with stroke in an inpatient setting can achieve hundreds of repetitions of task-specific training in 1-hr sessions. As expected, all participants improved on functional outcome measures. Future studies are needed to determine whether this high-repetition training program results in better outcomes than current UE interventions. PMID:25005508

Opioid modulation of ingestive behaviors in woodchucks and racoons.

PubMed

Nizielski, S E; Morley, J E; Gosnell, B A; Seal, U S; Levine, A S

1985-02-01

We have examined the effect on feeding of opioid blockade with naloxone in two species which demonstrate a marked seasonality in their feeding patterns, the racoon (Procyon lotor) and the woodchuck (Marmota monax). Naloxone suppressed food intake in the woodchuck which is a true hibernator. Naloxone failed to suppress food intake in the racoon and, in fact, enhanced intake of a preferred sucrose solution. In the racoon, ir-dynorphine concentrations were extremely high in the hypothalamus compared to the values obtained in rats and woodchucks. We suggest that possible explanations for the lack of responsiveness to opiates in racoons may be their extremely high daily food intake relatively to body mass when compared to woodchucks and rats and the high levels of ir-dynorphin may be sufficient to overcome the inhibitory effect of naloxone. These studies stress the occurrence of species diversity in the response to opioid antagonism.

Ni-base superalloy powder-processed porous layer for gas cooling in extreme environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Emma M. H.; Heidloff, Andrew J.; Byrd, David J.

Extreme high temperature conditions demand novel solutions for hot gas filters and coolant access architectures, i.e., porous layers on exposed components. These high temperatures, for example in current turbine engines, are at or exceeding current material limits for high temperature oxidation/corrosion, creep resistance, and, even, melting temperature. Thus novel blade designs allowing greater heat removal are required to maintain airfoil temperatures below melting and/ or rapid creep deformation limits. Gas atomized Ni-base superalloy powders were partially sintered into porous layers to allow full-surface, transpirational cooling of the surface of airfoils. Furthermore, these powder-processed porous layers were fully characterized for surface,more » morphology, cross-sectional microstructure, and mechanical strength characteristics. A sintering model based on pure Ni surface diffusion correlated well with the experimental results and allowed reasonable control over the partial sintering process to obtain a specified level of porosity within the porous layer.« less

A Neuroscience Approach to Optimizing Brain Resources for Human Performance in Extreme Environments

PubMed Central

Paulus, Martin P.; Potterat, Eric G.; Taylor, Marcus K.; Van Orden, Karl F.; Bauman, James; Momen, Nausheen; Padilla, Genieleah A.; Swain, Judith L.

2009-01-01

Extreme environments requiring optimal cognitive and behavioral performance occur in a wide variety of situations ranging from complex combat operations to elite athletic competitions. Although a large literature characterizes psychological and other aspects of individual differences in performances in extreme environments, virtually nothing is known about the underlying neural basis for these differences. This review summarizes the cognitive, emotional, and behavioral consequences of exposure to extreme environments, discusses predictors of performance, and builds a case for the use of neuroscience approaches to quantify and understand optimal cognitive and behavioral performance. Extreme environments are defined as an external context that exposes individuals to demanding psychological and/or physical conditions, and which may have profound effects on cognitive and behavioral performance. Examples of these types of environments include combat situations, Olympic-level competition, and expeditions in extreme cold, at high altitudes, or in space. Optimal performance is defined as the degree to which individuals achieve a desired outcome when completing goal-oriented tasks. It is hypothesized that individual variability with respect to optimal performance in extreme environments depends on a well “contextualized” internal body state that is associated with an appropriate potential to act. This hypothesis can be translated into an experimental approach that may be useful for quantifying the degree to which individuals are particularly suited to performing optimally in demanding environments. PMID:19447132

Noise and light exposures for extremely low birth weight newborns during their stay in the neonatal intensive care unit.

PubMed

Lasky, Robert E; Williams, Amber L

2009-02-01

The objectives of this study were to characterize noise and light levels for extremely low birth weight newborns throughout their stay in the NICU, evaluate factors influencing noise and light levels, and determine whether exposures meet recommendations from the American Academy of Pediatrics. Sound and light were measured inside the beds of extremely low birth weight newborns (n = 22) from birth to discharge. Measurements were recorded for 20 consecutive hours weekly from birth until 36 weeks' postmenstrual age, biweekly until 40 weeks, and every 4 weeks thereafter. Clinical variables including bed type and method of respiratory support were recorded at each session. Age-related changes in respiratory support and bed type explained the weekly increase of 0.22 dB in sound level and 3.67 lux in light level. Old incubators were the noisiest bed types, and new incubators were the quietest. Light levels were significantly higher in open beds than in incubators. The variations in noise and light levels over time were greatest for open beds. Noise and light levels were much less affected by respiratory support in incubators compared with open beds. A typical extremely low birth weight neonate was exposed to noise levels averaging 56.44 dB(A) and light levels averaging 70.56 lux during their stay from 26 to 42 weeks' postmenstrual age in the NICU. Noise levels were rarely within American Academy of Pediatrics recommendations (5.51% of the time), whereas light levels almost always met recommendations (99.37% of the time). Bed type and respiratory support explained differences in noise and light levels that extremely low birth weight newborns experience during their hospital stay. Noise levels exceeded recommendations, although evidence supporting those recommendations is lacking. Well-designed intervention studies are needed to determine the effects of noise reduction on the development of extremely low birth weight newborns.

Extremely strong self-assembly of a bimetallic salen complex visualized at the single-molecule level.

PubMed

Salassa, Giovanni; Coenen, Michiel J J; Wezenberg, Sander J; Hendriksen, Bas L M; Speller, Sylvia; Elemans, Johannes A A W; Kleij, Arjan W

2012-04-25

A bis-Zn(salphen) structure shows extremely strong self-assembly both in solution as well as at the solid-liquid interface as evidenced by scanning tunneling microscopy, competitive UV-vis and fluorescence titrations, dynamic light scattering, and transmission electron microscopy. Density functional theory analysis on the Zn(2) complex rationalizes the very high stability of the self-assembled structures provoked by unusual oligomeric (Zn-O)(n) coordination motifs within the assembly. This coordination mode is strikingly different when compared with mononuclear Zn(salphen) analogues that form dimeric structures having a typical Zn(2)O(2) central unit. The high stability of the multinuclear structure therefore holds great promise for the development of stable self-assembled monolayers with potential for new opto-electronic materials.

Constraints on the extremely-high energy cosmic neutrino flux with the IceCube 2008-2009 data

NASA Astrophysics Data System (ADS)

Abbasi, R.; Abdou, Y.; Abu-Zayyad, T.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Bay, R.; Bazo Alba, J. L.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker, J. K.; Becker, K.-H.; Benabderrahmane, M. L.; Benzvi, S.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bindig, D.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Braun, J.; Brown, A. M.; Buitink, S.; Carson, M.; Chirkin, D.; Christy, B.; Clem, J.; Clevermann, F.; Cohen, S.; Colnard, C.; Cowen, D. F.; D'Agostino, M. V.; Danninger, M.; Daughhetee, J.; Davis, J. C.; de Clercq, C.; Demirörs, L.; Denger, T.; Depaepe, O.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; Deyoung, T.; Díaz-Vélez, J. C.; Dierckxsens, M.; Dreyer, J.; Dumm, J. P.; Ehrlich, R.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feusels, T.; Filimonov, K.; Finley, C.; Fischer-Wasels, T.; Foerster, M. M.; Fox, B. D.; Franckowiak, A.; Franke, R.; Gaisser, T. K.; Gallagher, J.; Geisler, M.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Goodman, J. A.; Gora, D.; Grant, D.; Griesel, T.; Groß, A.; Grullon, S.; Gurtner, M.; Ha, C.; Hallgren, A.; Halzen, F.; Han, K.; Hanson, K.; Heinen, D.; Helbing, K.; Herquet, P.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Homeier, A.; Hoshina, K.; Hubert, D.; Huelsnitz, W.; Hülß, J.-P.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobsen, J.; Japaridze, G. S.; Johansson, H.; Joseph, J. M.; Kampert, K.-H.; Kappes, A.; Karg, T.; Karle, A.; Kelley, J. L.; Kenny, P.; Kiryluk, J.; Kislat, F.; Klein, S. R.; Köhne, J.-H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kopper, S.; Koskinen, D. J.; Kowalski, M.; Kowarik, T.; Krasberg, M.; Krings, T.; Kroll, G.; Kuwabara, T.; Labare, M.; Lafebre, S.; Laihem, K.; Landsman, H.; Larson, M. J.; Lauer, R.; Lünemann, J.; Madsen, J.; Majumdar, P.; Marotta, A.; Maruyama, R.; Mase, K.; Matis, H. S.; Meagher, K.; Merck, M.; Mészáros, P.; Meures, T.; Middell, E.; Milke, N.; Miller, J.; Montaruli, T.; Morse, R.; Movit, S. M.; Nahnhauer, R.; Nam, J. W.; Naumann, U.; Nießen, P.; Nygren, D. R.; Odrowski, S.; Olivas, A.; Olivo, M.; O'Murchadha, A.; Ono, M.; Panknin, S.; Paul, L.; Pérez de Los Heros, C.; Petrovic, J.; Piegsa, A.; Pieloth, D.; Porrata, R.; Posselt, J.; Price, P. B.; Przybylski, G. T.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Rizzo, A.; Rodrigues, J. P.; Roth, P.; Rothmaier, F.; Rott, C.; Ruhe, T.; Rutledge, D.; Ruzybayev, B.; Ryckbosch, D.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Schmidt, T.; Schönwald, A.; Schukraft, A.; Schultes, A.; Schulz, O.; Schunck, M.; Seckel, D.; Semburg, B.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Silvestri, A.; Slipak, A.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stephens, G.; Stezelberger, T.; Stokstad, R. G.; Stössl, A.; Stoyanov, S.; Strahler, E. A.; Straszheim, T.; Stür, M.; Sullivan, G. W.; Swillens, Q.; Taavola, H.; Taboada, I.; Tamburro, A.; Tepe, A.; Ter-Antonyan, S.; Tilav, S.; Toale, P. A.; Toscano, S.; Tosi, D.; Turčan, D.; van Eijndhoven, N.; Vandenbroucke, J.; van Overloop, A.; van Santen, J.; Vehring, M.; Voge, M.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Walter, M.; Weaver, Ch.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Williams, D. R.; Wischnewski, R.; Wissing, H.; Wolf, M.; Wood, T. R.; Woschnagg, K.; Xu, C.; Xu, X. W.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.

2011-05-01

We report on a search for extremely-high energy neutrinos with energies greater than 106GeV using the data taken with the IceCube detector at the South Pole. The data was collected between April 2008 and May 2009 with the half-completed IceCube array. The absence of signal candidate events in the sample of 333.5 days of live time significantly improves model-independent limits from previous searches and allows to place a limit on the diffuse flux of cosmic neutrinos with an E-2 spectrum in the energy range 2.0×106-6.3×109GeV to a level of E2ϕ≤3.6×10-8GeVcm-2sec-1sr-1.

Latin America and the Caribbean: Issues for the 109th Congress

DTIC Science & Technology

2005-05-26

Dominican tax on drinks containing high fructose corn syrup , a major U.S. product, that had threatened the country’s chances of being included in the U.S...has complained about Mexico’s 20% tax on soft drinks made with high fructose corn syrup (HFCS), with devastating impact on HFCS sales. Under...unstable political environment. In Peru, President Alejandro Toledo remains extremely unpopular, but the economy has continued to grow at high levels

Global Warming Denial: The Human Brain on Extremes

NASA Astrophysics Data System (ADS)

Marrouch, N.; Johnson, B. T.; Slawinska, J. M.

2016-12-01

Future assessments of climate change rely on multi-model intercomparisons, and projections of the extreme events frequency are of particular interest as associated with significant economic costs and social threats. Notably, systematically simulated increases in the number of extreme weather events agree well with observational data over the last decade. At the same time, as the climate grows more volatile, widespread denial of climate change and its anthropocentric causes continues to proliferate (based on nationally representative U.S. polls). Simultaneous increases in both high-impact exposure and its denial is in stark contrast with our knowledge of socio-natural dynamics and its models. Disentangling this paradox requires an understanding of the origins of global warming denial at an individual level, and how subsequently it propagates across social networks of many scales, shaping global policies. However, as the real world and its dynamical models are complex (high-dimensional and coupled), separating the particular feedback of interest remains a challenge. Here, we demonstrate this feedback in a controlled experiment, where increasing unpredictability using helplessness-training paradigms induces changes in global warming denial, and the endorsement of conservative ideology. We explain these results in the context of evolutionary theory framing self-deception and denial as remnants of evolutionary processes that shaped and facilitated the survival of the human species. Further we link these findings to changes in neural and higher-level cognitive processes in response to unpredictable stimuli. We argue that climate change denial is an example of an extreme belief system that carries the potential to threaten the wellbeing of both humans and other species alike. It is therefore crucial to better quantify climate denial using social informatics tools that provide the means to improve its representations in coupled socio-geophysical models to mitigate its effects on global and local policies.

Identification of Alzheimer's disease and mild cognitive impairment using multimodal sparse hierarchical extreme learning machine.

PubMed

Kim, Jongin; Lee, Boreom

2018-05-07

Different modalities such as structural MRI, FDG-PET, and CSF have complementary information, which is likely to be very useful for diagnosis of AD and MCI. Therefore, it is possible to develop a more effective and accurate AD/MCI automatic diagnosis method by integrating complementary information of different modalities. In this paper, we propose multi-modal sparse hierarchical extreme leaning machine (MSH-ELM). We used volume and mean intensity extracted from 93 regions of interest (ROIs) as features of MRI and FDG-PET, respectively, and used p-tau, t-tau, and Aβ42 as CSF features. In detail, high-level representation was individually extracted from each of MRI, FDG-PET, and CSF using a stacked sparse extreme learning machine auto-encoder (sELM-AE). Then, another stacked sELM-AE was devised to acquire a joint hierarchical feature representation by fusing the high-level representations obtained from each modality. Finally, we classified joint hierarchical feature representation using a kernel-based extreme learning machine (KELM). The results of MSH-ELM were compared with those of conventional ELM, single kernel support vector machine (SK-SVM), multiple kernel support vector machine (MK-SVM) and stacked auto-encoder (SAE). Performance was evaluated through 10-fold cross-validation. In the classification of AD vs. HC and MCI vs. HC problem, the proposed MSH-ELM method showed mean balanced accuracies of 96.10% and 86.46%, respectively, which is much better than those of competing methods. In summary, the proposed algorithm exhibits consistently better performance than SK-SVM, ELM, MK-SVM and SAE in the two binary classification problems (AD vs. HC and MCI vs. HC). © 2018 Wiley Periodicals, Inc.

Acclimation of killifish to thermal extremes of hot spring: Transcription of gonadal and liver heat shock genes.

PubMed

Akbarzadeh, Arash; Leder, Erica H

2016-01-01

In this study, we explored the hypothesis that killifish acclimate to thermal extremes through regulation of genes involved in stress and metabolism. We examined the liver and gonadal transcription of heat shock proteins (hsp70, hsp90a, hsp90b), glucokinase (gck), and high mobility group b1 (hmgb1) protein in wild killifish species from hot springs and rivers using quantitative real-time PCR. Moreover, we exposed a river killifish species to a long-term thermal regime of hot spring (37-40°C) and examined the liver transcription of the heat shock genes. Our results showed that hot spring killifish showed a significant, strong upregulation of liver hsp90a. Moreover, the testicular transcript levels of hsp90a, hsp90b, and hsp70 were higher in hot spring killifish than the river ones. The results of the common garden experiments showed that the transcripts of hsp70, hsp90b, and hmgb1 were mildly induced (> twofold) at the time when temperature reached to 37-40°C, while the transcripts of hsp90a were strongly induced (17-fold increase). The level of hsp90a was dramatically more upregulated when fish were maintained in thermal extreme (42-fold change higher than in ambient temperature). Moreover, a significant downregulation of gck transcripts was observed at the time when temperature was raised to 37-40°C (80-fold decrease) and during exposure to long-term thermal extreme (56-fold decrease). It can be concluded that the regulation of heat shock genes particularly hsp90a might be a key factor of the acclimation of fish to high temperature environments like hot springs. Copyright © 2015 Elsevier Inc. All rights reserved.

USACE Extreme Sea Levels Advice on Guidance on Procedures to Evaluate and Adapt to Changes in Mean and Extreme Sea Levels.

DTIC Science & Technology

2014-09-09

influences of changes in extreme sea levels as they affect the four mission areas of USACE: storm damage reduction, flood risk mitigation, ecosystems...winds and surface pressure can occur on the scale of the inundation area under investigation, cyclonic climatologies and more sophisticated inundation...Federal and State agencies (particularly the Bureau of Meteorology) providing forecast data (e.g. DIPNR, 2005, Appendix N). In more developed areas of

Chapter 12: Sea Level Rise

NASA Technical Reports Server (NTRS)

Sweet, W. V.; Horton, R.; Kopp, R. E.; LeGrande, A. N.; Romanou, A.

2017-01-01

Global mean sea level (GMSL) has risen by about 7-8 inches (about 16-21 cm) since 1900, with about 3 of those inches (about 7 cm) occurring since 1993. Human-caused climate change has made a substantial contribution to GMSL rise since 1900, contributing to a rate of rise that is greater than during any preceding century in at least 2,800 years. Relative to the year 2000, GMSL is very likely to rise by 0.3-0.6 feet (9-18 cm) by 2030, 0.5-1.2 feet (15-38 cm) by 2050, and 1.0-4.3 feet (30-130 cm) by 2100. Future pathways have little effect on projected GMSL rise in the first half of the century, but significantly affect projections for the second half of the century. Emerging science regarding Antarctic ice sheet stability suggests that, for high emission scenarios, a GMSL rise exceeding 8 feet (2.4 m) by 2100 is physically possible, although the probability of such an extreme outcome cannot currently be assessed. Regardless of pathway, it is extremely likely that GMSL rise will continue beyond 2100. Relative sea level (RSL) rise in this century will vary along U.S. coastlines due, in part, to changes in Earth's gravitational field and rotation from melting of land ice, changes in ocean circulation, and vertical land motion (very high confidence). For almost all future GMSL rise scenarios, RSL rise is likely to be greater than the global average in the U.S. Northeast and the western Gulf of Mexico. In intermediate and low GMSL rise scenarios, RSL rise is likely to be less than the global average in much of the Pacific Northwest and Alaska. For high GMSL rise scenarios, RSL rise is likely to be higher than the global average along all U.S. coastlines outside Alaska. Almost all U.S. coastlines experience more than global mean sea level rise in response to Antarctic ice loss, and thus would be particularly affected under extreme GMSL rise scenarios involving substantial Antarctic mass loss. As sea levels have risen, the number of tidal floods each year that cause minor impacts (also called "nuisance floods") have increased 5- to 10-fold since the 1960s in several U.S. coastal cities. Rates of increase are accelerating in over 25 Atlantic and Gulf Coast cities. Tidal flooding will continue increasing in depth, frequency, and extent this century. Assuming storm characteristics do not change, sea level rise will increase the frequency and extent of extreme flooding associated with coastal storms, such as hurricanes and nor'easters. A projected increase in the intensity of hurricanes in the North Atlantic could increase the probability of extreme flooding along most of the U.S. Atlantic and Gulf Coast states beyond what would be projected based solely on RSL rise. However, there is low confidence in the projected increase in frequency of intense Atlantic hurricanes, and the associated flood risk amplification and flood effects could be offset or amplified by such factors as changes in overall storm frequency or tracks.

Effect of beta-endorphin imprinting during late pregnancy on the brain serotonin and plasma nocistatin levels of adult male rats.

PubMed

Tekes, K; Gyenge, M; Hantos, M; Csaba, G

2007-07-01

Female rats were treated with 10 microg of beta-endorphin on the 19th day of pregnancy. Offspring were studied when five months old. Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) content in four brain regions were determined by HPLC-EC and the nocistatin levels of blood plasma using RIA methods. In each brain region studied, the 5-HT levels were highly significantly reduced and that of 5-HIAA in three regions was highly significantly increased. When 5HIAA/5HT ratios, as a measure of serotonin turnover, were calculated, imprinted animals showed extremely high values. Plasma nocistatin level was also significantly elevated. The results call attention to the effect of perinatal endorphin imprinting and its long-term consequences (e.g., setting of aggressiveness, pain tolerance).

Peak power ratio generator

DOEpatents

Moyer, Robert D.

1985-01-01

A peak power ratio generator is described for measuring, in combination with a conventional power meter, the peak power level of extremely narrow pulses in the gigahertz radio frequency bands. The present invention in a preferred embodiment utilizes a tunnel diode and a back diode combination in a detector circuit as the only high speed elements. The high speed tunnel diode provides a bistable signal and serves as a memory device of the input pulses for the remaining, slower components. A hybrid digital and analog loop maintains the peak power level of a reference channel at a known amount. Thus, by measuring the average power levels of the reference signal and the source signal, the peak power level of the source signal can be determined.

Peak power ratio generator

DOEpatents

Moyer, R.D.

A peak power ratio generator is described for measuring, in combination with a conventional power meter, the peak power level of extremely narrow pulses in the gigahertz radio frequency bands. The present invention in a preferred embodiment utilizes a tunnel diode and a back diode combination in a detector circuit as the only high speed elements. The high speed tunnel diode provides a bistable signal and serves as a memory device of the input pulses for the remaining, slower components. A hybrid digital and analog loop maintains the peak power level of a reference channel at a known amount. Thus, by measuring the average power levels of the reference signal and the source signal, the peak power level of the source signal can be determined.

Water storage equity and safety assurance policy to mitigate potential 'dual-extreme cumulative threats' in agricultural catchments

NASA Astrophysics Data System (ADS)

Pisaniello, John D.; Tingey-Holyoak, Joanne L.

2017-02-01

Farm dams that are not managed properly at the individual level can create water storage equity and safety threats to downstream communities and the environment that aggregate at the catchment level: a potential 'dual-extreme cumulative' problem. The paper provides indicative evidence and develops understanding of this novel phenomenon and associated policy needs within the Australian setting comprising dual hydrologic extremes of floods and droughts, further exacerbated by climate change. This is achieved through comparative case studies involving surveys of both dam owner perceptions and dam management practices in four States representing a complete range of integrated policy approaches from weak to strong. Survey results find most farmers do not believe dam maintenance is important, will undertake spillway blocking and do not plan for emergencies. These results are supported by physical on-site findings of farmers neglecting dams and blocking or under-designing spillways, in turn storing more water than they are entitled and creating unsafe dams at both the individual and cumulative levels. From detailed cross-case comparative assessment against policy context, it emerges that on-farm perceptions and practices form a range of 'acceptability' of dam management that directly reflects policy strength and integration in each setting. The paper advances the international small dams policy, agricultural water management and hydrology literatures, evidencing the need for effective integrated policy to mitigate dual extreme cumulative threats. Importantly, guidance is provided to jurisdictions internationally with high inter-annual rainfall variation on how best to design integrated policy that can achieve both water storage equity and safety in agricultural catchments.

Estimating the extreme low-temperature event using nonparametric methods

NASA Astrophysics Data System (ADS)

D'Silva, Anisha

This thesis presents a new method of estimating the one-in-N low temperature threshold using a non-parametric statistical method called kernel density estimation applied to daily average wind-adjusted temperatures. We apply our One-in-N Algorithm to local gas distribution companies (LDCs), as they have to forecast the daily natural gas needs of their consumers. In winter, demand for natural gas is high. Extreme low temperature events are not directly related to an LDCs gas demand forecasting, but knowledge of extreme low temperatures is important to ensure that an LDC has enough capacity to meet customer demands when extreme low temperatures are experienced. We present a detailed explanation of our One-in-N Algorithm and compare it to the methods using the generalized extreme value distribution, the normal distribution, and the variance-weighted composite distribution. We show that our One-in-N Algorithm estimates the one-in- N low temperature threshold more accurately than the methods using the generalized extreme value distribution, the normal distribution, and the variance-weighted composite distribution according to root mean square error (RMSE) measure at a 5% level of significance. The One-in- N Algorithm is tested by counting the number of times the daily average wind-adjusted temperature is less than or equal to the one-in- N low temperature threshold.

The effect of consumer pressure and abiotic stress on positive plant interactions are mediated by extreme climatic events.

PubMed

Filazzola, Alessandro; Liczner, Amanda Rae; Westphal, Michael; Lortie, Christopher J

2018-01-01

Environmental extremes resulting from a changing climate can have profound implications for plant interactions in desert communities. Positive interactions can buffer plant communities from abiotic stress and consumer pressure caused by climatic extremes, but limited research has explored this empirically. We tested the hypothesis that the mechanism of shrub facilitation on an annual plant community can change with precipitation extremes in deserts. During years of extreme drought and above-average rainfall in a desert, we measured plant interactions and biomass while manipulating a soil moisture gradient and reducing consumer pressure. Shrubs facilitated the annual plant community at all levels of soil moisture through reductions in microclimatic stress in both years and herbivore protection in the wet year only. Shrub facilitation and the high rainfall year contributed to the dominance of a competitive annual species in the plant community. Precipitation patterns in deserts determine the magnitude and type of facilitation mechanisms. Moreover, shrub facilitation mediates the interspecific competition within the associated annual community between years with different rainfall amounts. Examining multiple drivers during extreme climate events is a challenging area of research, but it is a necessary consideration given forecasts predicting that these events will increase in frequency and magnitude. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Reliability and Validity of a Japanese-language and Culturally Adapted Version of the Musculoskeletal Tumor Society Scoring System for the Lower Extremity.

PubMed

Iwata, Shintaro; Uehara, Kosuke; Ogura, Koichi; Akiyama, Toru; Shinoda, Yusuke; Yonemoto, Tsukasa; Kawai, Akira

2016-09-01

The Musculoskeletal Tumor Society (MSTS) scoring system is a widely used functional evaluation tool for patients treated for musculoskeletal tumors. Although the MSTS scoring system has been validated in English and Brazilian Portuguese, a Japanese version of the MSTS scoring system has not yet been validated. We sought to determine whether a Japanese-language translation of the MSTS scoring system for the lower extremity had (1) sufficient reliability and internal consistency, (2) adequate construct validity, and (3) reasonable criterion validity compared with the Toronto Extremity Salvage Score (TESS) and SF-36 using psychometric analysis. The Japanese version of the MSTS scoring system was developed using accepted guidelines, which included translation of the English version of the MSTS into Japanese by five native Japanese bilingual musculoskeletal oncology surgeons and integrated into one document. One hundred patients with a diagnosis of intermediate or malignant bone or soft tissue tumors located in the lower extremity and who had undergone tumor resection with or without reconstruction or amputation participated in this study. Reliability was evaluated by test-retest analysis, and internal consistency was established by Cronbach's alpha coefficient. Construct validity was evaluated using the principal factor analysis and Akaike information criterion network. Criterion validity was evaluated by comparing the MSTS scoring system with the TESS and SF-36. Test-retest analysis showed a high intraclass correlation coefficient (0.92; 95% CI, 0.88-0.95), indicating high reliability of the Japanese version of the MSTS scoring system, although a considerable ceiling effect was observed, with 23 patients (23%) given the maximum score. Cronbach's alpha coefficient was 0.87 (95% CI, 0.82-0.90), suggesting a high level of internal consistency. Factor analysis revealed that all items had high loading values and communalities; we identified a central role for the items "walking" and "gait" according to the Akaike information criterion network. The total MSTS score was correlated with that of the TESS (r = 0.81; 95% CI, 0.73-0.87; p < 0.001) and the physical component summary and physical functioning of the SF-36. The Japanese-language translation of the MSTS scoring system for the lower extremity has sufficient reliability and reasonable validity. Nevertheless, the observation of a ceiling effect suggests poor ability of this system to discriminate from among patients who have a high level of function.

Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments.

PubMed

Yang, Ji; Li, Wen-Rong; Lv, Feng-Hua; He, San-Gang; Tian, Shi-Lin; Peng, Wei-Feng; Sun, Ya-Wei; Zhao, Yong-Xin; Tu, Xiao-Long; Zhang, Min; Xie, Xing-Long; Wang, Yu-Tao; Li, Jin-Quan; Liu, Yong-Gang; Shen, Zhi-Qiang; Wang, Feng; Liu, Guang-Jian; Lu, Hong-Feng; Kantanen, Juha; Han, Jian-Lin; Li, Meng-Hua; Liu, Ming-Jun

2016-10-01

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8-9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Improving power and robustness for detecting genetic association with extreme-value sampling design.

PubMed

Chen, Hua Yun; Li, Mingyao

2011-12-01

Extreme-value sampling design that samples subjects with extremely large or small quantitative trait values is commonly used in genetic association studies. Samples in such designs are often treated as "cases" and "controls" and analyzed using logistic regression. Such a case-control analysis ignores the potential dose-response relationship between the quantitative trait and the underlying trait locus and thus may lead to loss of power in detecting genetic association. An alternative approach to analyzing such data is to model the dose-response relationship by a linear regression model. However, parameter estimation from this model can be biased, which may lead to inflated type I errors. We propose a robust and efficient approach that takes into consideration of both the biased sampling design and the potential dose-response relationship. Extensive simulations demonstrate that the proposed method is more powerful than the traditional logistic regression analysis and is more robust than the linear regression analysis. We applied our method to the analysis of a candidate gene association study on high-density lipoprotein cholesterol (HDL-C) which includes study subjects with extremely high or low HDL-C levels. Using our method, we identified several SNPs showing a stronger evidence of association with HDL-C than the traditional case-control logistic regression analysis. Our results suggest that it is important to appropriately model the quantitative traits and to adjust for the biased sampling when dose-response relationship exists in extreme-value sampling designs. © 2011 Wiley Periodicals, Inc.

A Study of Particulate Matter (PM2.5) Concentration Variance by Distance from Train Platform at a Major Bay Area Rapid Transit (BART) Railway Station

NASA Astrophysics Data System (ADS)

Solis, M.; Nguyen, H.; Adeyan, A.; Adeyan, E.; Taylor, S.; Hardaway, K.; Peterson, E.; Ortega, J.; Marshall, R.

2017-12-01

Over the past five years, the East Bay Academy for Young Scientists (EBAYS) has been investigating air quality at Bay Area Rapid Transit (BART) train stations. In particular, prior EBAYS research has revealed extremely high levels of particulate matter (PM 2.5) at the multi-leveled Embarcadero Station, which is underground and is one of the most frequently visited stations in the entire BART system. During the summer of 2017 data was collected to determine whether or not air quality differed on the three levels of this station. In conducting this study the research team was separated into pairs, each pair in possession of a Dustrak II or AirBeam PM analyzer and each pair assigned to a particular level. Within each measurement trial data was collected for 15 minutes. Measurements were also made on the eastern and western ends of the platforms to detect possible variations in PM concentration. Preliminary results obtained thus far indicate that dangerously high levels of PM 2.5 concentration occur on all three levels of the station. This is especially problematic because it suggests that individuals who spend extensive amounts of time at this station (e.g., station agents and other workers) are exposed to extremely high PM 2.5 concentration levels and as a result are working under conditions that are quite hazardous to their health. Based on observations made during testing, increased levels of PM 2.5 tend to correlate with the departure or arrival of BART trains that results in particulate matter being scattered about the train platform and other levels. Further studies should be conducted to verify this observation and to contribute to better understanding the sources and behavior of PM 2.5 at each level of the station.

Analysis of the dependence of extreme rainfalls

NASA Astrophysics Data System (ADS)

Padoan, Simone; Ancey, Christophe; Parlange, Marc

2010-05-01

The aim of spatial analysis is to quantitatively describe the behavior of environmental phenomena such as precipitation levels, wind speed or daily temperatures. A number of generic approaches to spatial modeling have been developed[1], but these are not necessarily ideal for handling extremal aspects given their focus on mean process levels. The areal modelling of the extremes of a natural process observed at points in space is important in environmental statistics; for example, understanding extremal spatial rainfall is crucial in flood protection. In light of recent concerns over climate change, the use of robust mathematical and statistical methods for such analyses has grown in importance. Multivariate extreme value models and the class of maxstable processes [2] have a similar asymptotic motivation to the univariate Generalized Extreme Value (GEV) distribution , but providing a general approach to modeling extreme processes incorporating temporal or spatial dependence. Statistical methods for max-stable processes and data analyses of practical problems are discussed by [3] and [4]. This work illustrates methods to the statistical modelling of spatial extremes and gives examples of their use by means of a real extremal data analysis of Switzerland precipitation levels. [1] Cressie, N. A. C. (1993). Statistics for Spatial Data. Wiley, New York. [2] de Haan, L and Ferreria A. (2006). Extreme Value Theory An Introduction. Springer, USA. [3] Padoan, S. A., Ribatet, M and Sisson, S. A. (2009). Likelihood-Based Inference for Max-Stable Processes. Journal of the American Statistical Association, Theory & Methods. In press. [4] Davison, A. C. and Gholamrezaee, M. (2009), Geostatistics of extremes. Journal of the Royal Statistical Society, Series B. To appear.

Extremely Low Frequency Electromagnetic Fields impair the Cognitive and Motor Abilities of Honey Bees.

PubMed

Shepherd, S; Lima, M A P; Oliveira, E E; Sharkh, S M; Jackson, C W; Newland, P L

2018-05-21

Extremely low frequency electromagnetic field (ELF EMF) pollution from overhead powerlines is known to cause biological effects across many phyla, but these effects are poorly understood. Honey bees are important pollinators across the globe and due to their foraging flights are exposed to relatively high levels of ELF EMF in proximity to powerlines. Here we ask how acute exposure to 50 Hz ELF EMFs at levels ranging from 20-100 µT, found at ground level below powerline conductors, to 1000-7000 µT, found within 1 m of the conductors, affects honey bee olfactory learning, flight, foraging activity and feeding. ELF EMF exposure was found to reduce learning, alter flight dynamics, reduce the success of foraging flights towards food sources, and feeding. The results suggest that 50 Hz ELF EMFs emitted from powerlines may represent a prominent environmental stressor for honey bees, with the potential to impact on their cognitive and motor abilities, which could in turn reduce their ability to pollinate crops.

Knowledge discovery and nonlinear modeling can complement climate model simulations for predictive insights about climate extremes and their impacts

NASA Astrophysics Data System (ADS)

Ganguly, A. R.; Steinbach, M.; Kumar, V.

2009-12-01

The IPCC AR4 not only provided conclusive evidence about anticipated global warming at century scales, but also indicated with a high level of certainty that the warming is caused by anthropogenic emissions. However, an outstanding knowledge-gap is to develop credible projections of climate extremes and their impacts. Climate extremes are defined in this context as extreme weather and hydrological events, as well as changes in regional hydro-meteorological patterns, especially at decadal scales. While temperature extremes from climate models have relatively better skills, hydrological variables and their extremes have significant shortcomings. Credible projections about tropical storms, sea level rise, coastal storm surge, land glacier melts, and landslides remain elusive. The next generation of climate models is expected to have higher precision. However, their ability to provide more accurate projections of climate extremes remains to be tested. Projections of observed trends into the future may not be reliable in non-stationary environments like climate change, even though functional relationships derived from physics may hold. On the other hand, assessments of climate change impacts which are useful for stakeholders and policy makers depend critically on regional and decadal scale projections of climate extremes. Thus, climate impacts scientists often need to develop qualitative inferences about the not so-well predicted climate extremes based on insights from observations (e.g., increased hurricane intensity) or conceptual understanding (e.g., relation of wildfires to regional warming or drying and hurricanes to SST). However, neither conceptual understanding nor observed trends may be reliable when extrapolating in a non-stationary environment. These urgent societal priorities offer fertile grounds for nonlinear modeling and knowledge discovery approaches. Thus, qualitative inferences on climate extremes and impacts may be transformed into quantitative predictive insights based on a combination of hypothesis-guided data analysis and relatively hypothesis-free but data-guided discovery processes. The analysis and discovery approaches need to be cognizant of climate data characteristics like nonlinear processes, low-frequency variability, long-range spatial dependence and long-memory temporal processes; the value of physically-motivated conceptual understanding and functional associations; as well as possible thresholds and tipping points in the impacted natural, engineered or human systems. Case studies focusing on new methodologies as well as novel climate insights are discussed with a focus on stakeholder requirements.

High-Performance, Radiation-Hardened Electronics for Space Environments

NASA Technical Reports Server (NTRS)

Keys, Andrew S.; Watson, Michael D.; Frazier, Donald O.; Adams, James H.; Johnson, Michael A.; Kolawa, Elizabeth A.

2007-01-01

The Radiation Hardened Electronics for Space Environments (RHESE) project endeavors to advance the current state-of-the-art in high-performance, radiation-hardened electronics and processors, ensuring successful performance of space systems required to operate within extreme radiation and temperature environments. Because RHESE is a project within the Exploration Technology Development Program (ETDP), RHESE's primary customers will be the human and robotic missions being developed by NASA's Exploration Systems Mission Directorate (ESMD) in partial fulfillment of the Vision for Space Exploration. Benefits are also anticipated for NASA's science missions to planetary and deep-space destinations. As a technology development effort, RHESE provides a broad-scoped, full spectrum of approaches to environmentally harden space electronics, including new materials, advanced design processes, reconfigurable hardware techniques, and software modeling of the radiation environment. The RHESE sub-project tasks are: SelfReconfigurable Electronics for Extreme Environments, Radiation Effects Predictive Modeling, Radiation Hardened Memory, Single Event Effects (SEE) Immune Reconfigurable Field Programmable Gate Array (FPGA) (SIRF), Radiation Hardening by Software, Radiation Hardened High Performance Processors (HPP), Reconfigurable Computing, Low Temperature Tolerant MEMS by Design, and Silicon-Germanium (SiGe) Integrated Electronics for Extreme Environments. These nine sub-project tasks are managed by technical leads as located across five different NASA field centers, including Ames Research Center, Goddard Space Flight Center, the Jet Propulsion Laboratory, Langley Research Center, and Marshall Space Flight Center. The overall RHESE integrated project management responsibility resides with NASA's Marshall Space Flight Center (MSFC). Initial technology development emphasis within RHESE focuses on the hardening of Field Programmable Gate Arrays (FPGA)s and Field Programmable Analog Arrays (FPAA)s for use in reconfigurable architectures. As these component/chip level technologies mature, the RHESE project emphasis shifts to focus on efforts encompassing total processor hardening techniques and board-level electronic reconfiguration techniques featuring spare and interface modularity. This phased approach to distributing emphasis between technology developments provides hardened FPGA/FPAAs for early mission infusion, then migrates to hardened, board-level, high speed processors with associated memory elements and high density storage for the longer duration missions encountered for Lunar Outpost and Mars Exploration occurring later in the Constellation schedule.

Applying systems biology methods to the study of human physiology in extreme environments

PubMed Central

2013-01-01

Systems biology is defined in this review as ‘an iterative process of computational model building and experimental model revision with the aim of understanding or simulating complex biological systems’. We propose that, in practice, systems biology rests on three pillars: computation, the omics disciplines and repeated experimental perturbation of the system of interest. The number of ethical and physiologically relevant perturbations that can be used in experiments on healthy humans is extremely limited and principally comprises exercise, nutrition, infusions (e.g. Intralipid), some drugs and altered environment. Thus, we argue that systems biology and environmental physiology are natural symbionts for those interested in a system-level understanding of human biology. However, despite excellent progress in high-altitude genetics and several proteomics studies, systems biology research into human adaptation to extreme environments is in its infancy. A brief description and overview of systems biology in its current guise is given, followed by a mini review of computational methods used for modelling biological systems. Special attention is given to high-altitude research, metabolic network reconstruction and constraint-based modelling. PMID:23849719

Towards validated chemistry at extreme conditions: reactive MD simulations of shocked Polyvinyl Nitrate and Nitromethane

NASA Astrophysics Data System (ADS)

Islam, Md Mahbubul; Strachan, Alejandro

A detailed atomistic-level understanding of the ultrafast chemistry of detonation processes of high energy materials is crucial to understand their performance and safety. Recent advances in laser shocks and ultra-fast spectroscopy is yielding the first direct experimental evidence of chemistry at extreme conditions. At the same time, reactive molecular dynamics (MD) in current high-performance computing platforms enable an atomic description of shock-induced chemistry with length and timescales approaching those of experiments. We use MD simulations with the reactive force field ReaxFF to investigate the shock-induced chemical decomposition mechanisms of polyvinyl nitrate (PVN) and nitromethane (NM). The effect of shock pressure on chemical reaction mechanisms and kinetics of both the materials are investigated. For direct comparison of our simulation results with experimentally derived IR absorption data, we performed spectral analysis using atomistic velocity at various shock conditions. The combination of reactive MD simulations and ultrafast spectroscopy enables both the validation of ReaxFF at extreme conditions and contributes to the interpretation of the experimental data relating changes in spectral features to atomic processes. Office of Naval Research MURI program.

Structural Extremes in a Cretaceous Dinosaur

PubMed Central

Sereno, Paul C.; Wilson, Jeffrey A.; Witmer, Lawrence M.; Whitlock, John A.; Maga, Abdoulaye; Ide, Oumarou; Rowe, Timothy A.

2007-01-01

Fossils of the Early Cretaceous dinosaur, Nigersaurus taqueti, document for the first time the cranial anatomy of a rebbachisaurid sauropod. Its extreme adaptations for herbivory at ground-level challenge current hypotheses regarding feeding function and feeding strategy among diplodocoids, the larger clade of sauropods that includes Nigersaurus. We used high resolution computed tomography, stereolithography, and standard molding and casting techniques to reassemble the extremely fragile skull. Computed tomography also allowed us to render the first endocast for a sauropod preserving portions of the olfactory bulbs, cerebrum and inner ear, the latter permitting us to establish habitual head posture. To elucidate evidence of tooth wear and tooth replacement rate, we used photographic-casting techniques and crown thin sections, respectively. To reconstruct its 9-meter postcranial skeleton, we combined and size-adjusted multiple partial skeletons. Finally, we used maximum parsimony algorithms on character data to obtain the best estimate of phylogenetic relationships among diplodocoid sauropods. Nigersaurus taqueti shows extreme adaptations for a dinosaurian herbivore including a skull of extremely light construction, tooth batteries located at the distal end of the jaws, tooth replacement as fast as one per month, an expanded muzzle that faces directly toward the ground, and hollow presacral vertebral centra with more air sac space than bone by volume. A cranial endocast provides the first reasonably complete view of a sauropod brain including its small olfactory bulbs and cerebrum. Skeletal and dental evidence suggests that Nigersaurus was a ground-level herbivore that gathered and sliced relatively soft vegetation, the culmination of a low-browsing feeding strategy first established among diplodocoids during the Jurassic. PMID:18030355

Extreme Storm Surges in the North Sea

NASA Astrophysics Data System (ADS)

Goennert, G.; Buß, Th.; Mueller, O.; Thumm, S.

2009-04-01

Extreme Storm Surges in the North Sea Gabriele Gönnert, Olaf Müller, Thomas Buß and Sigrid Thumm Climate Change will cause a rise of the sea level and probably more frequent and more violent storm surges. This has serious consequences for the safety of people as well as for their values and assets behind the dikes. It is therefore inevitable to first assess how sea level rise and an extreme storm surge event designes. In a second step it is possible to determine the risk for specific locations and develop strategies. The Project XtremRisk - Extreme Storm Surges at the North Sea Coast and in Estuaries. Risk calculation and risk strategies, funded by the German Federal Government will help answering these questions. The „Source-Pathway-Receptor" Concept will be used as a basis for risk analysis and development of new strategies. The Project offers methods to assess the development of extreme events under the conditions of today. Under conditions reflecting the climate change it will be tried to design an extreme event. For these three main points will be considered: a) Analysis and calculation of each factor, which produce a storm surge and its maximum level occurring in the last 100 years. These are: - maximum surge level: surge (due to the wind), - influence of the tide and the interaction between surge and tide, - influence of external surges , b) The hydrodynamics of a storm surge cause nonlinear effects in the interaction of the named factors. These factors and effects will both be taken into account to calculate the magnitude of the extreme storm surge. This step is very complex and need additional examination by numerical models. c) Analysis of the different scenarios to mean sea level rise and to the increase of wind speed due to the climate change. The presentation will introduce methods and show first results of the analysis of extreme events and the mean sea level rise.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kastner, S.O.; Bhatia, A.K.

A generalized method for obtaining individual level population ratios is used to obtain relative intensities of extreme ultraviolet Fe XV emission lines in the range 284 --500 A, which are density dependent for electron densities in the tokamak regime or higher. Four lines in particular are found to attain quite high intensities in the high-density limit. The same calculation provides inelastic contributions to linewidths. The method connects level populations and level widths through total probabilities t/sub i/j, related to ''taboo'' probabilities of Markov chain theory. The t/sub i/j are here evaluated for a real atomic system, being therefore of potentialmore » interest to random-walk theorists who have been limited to idealized systems characterized by simplified transition schemes.« less

Rising sea levels will reduce extreme temperature variations in tide-dominated reef habitats.

PubMed

Lowe, Ryan Joseph; Pivan, Xavier; Falter, James; Symonds, Graham; Gruber, Renee

2016-08-01

Temperatures within shallow reefs often differ substantially from those in the surrounding ocean; therefore, predicting future patterns of thermal stresses and bleaching at the scale of reefs depends on accurately predicting reef heat budgets. We present a new framework for quantifying how tidal and solar heating cycles interact with reef morphology to control diurnal temperature extremes within shallow, tidally forced reefs. Using data from northwestern Australia, we construct a heat budget model to investigate how frequency differences between the dominant lunar semidiurnal tide and diurnal solar cycle drive ~15-day modulations in diurnal temperature extremes. The model is extended to show how reefs with tidal amplitudes comparable to their depth, relative to mean sea level, tend to experience the largest temperature extremes globally. As a consequence, we reveal how even a modest sea level rise can substantially reduce temperature extremes within tide-dominated reefs, thereby partially offsetting the local effects of future ocean warming.

Estimation of genetic parameters and breeding values across challenged environments to select for robust pigs.

PubMed

Herrero-Medrano, J M; Mathur, P K; ten Napel, J; Rashidi, H; Alexandri, P; Knol, E F; Mulder, H A

2015-04-01

Robustness is an important issue in the pig production industry. Since pigs from international breeding organizations have to withstand a variety of environmental challenges, selection of pigs with the inherent ability to sustain their productivity in diverse environments may be an economically feasible approach in the livestock industry. The objective of this study was to estimate genetic parameters and breeding values across different levels of environmental challenge load. The challenge load (CL) was estimated as the reduction in reproductive performance during different weeks of a year using 925,711 farrowing records from farms distributed worldwide. A wide range of levels of challenge, from favorable to unfavorable environments, was observed among farms with high CL values being associated with confirmed situations of unfavorable environment. Genetic parameters and breeding values were estimated in high- and low-challenge environments using a bivariate analysis, as well as across increasing levels of challenge with a random regression model using Legendre polynomials. Although heritability estimates of number of pigs born alive were slightly higher in environments with extreme CL than in those with intermediate levels of CL, the heritabilities of number of piglet losses increased progressively as CL increased. Genetic correlations among environments with different levels of CL suggest that selection in environments with extremes of low or high CL would result in low response to selection. Therefore, selection programs of breeding organizations that are commonly conducted under favorable environments could have low response to selection in commercial farms that have unfavorable environmental conditions. Sows that had experienced high levels of challenge at least once during their productive life were ranked according to their EBV. The selection of pigs using EBV ignoring environmental challenges or on the basis of records from only favorable environments resulted in a sharp decline in productivity as the level of challenge increased. In contrast, selection using the random regression approach resulted in limited change in productivity with increasing levels of challenge. Hence, we demonstrate that the use of a quantitative measure of environmental CL and a random regression approach can be comprehensively combined for genetic selection of pigs with enhanced ability to maintain high productivity in harsh environments.

Impact of surface coupling grids on tropical cyclone extremes in high-resolution atmospheric simulations

DOE PAGES

Zarzycki, Colin M.; Reed, Kevin A.; Bacmeister, Julio T.; ...

2016-02-25

This article discusses the sensitivity of tropical cyclone climatology to surface coupling strategy in high-resolution configurations of the Community Earth System Model. Using two supported model setups, we demonstrate that the choice of grid on which the lowest model level wind stress and surface fluxes are computed may lead to differences in cyclone strength in multi-decadal climate simulations, particularly for the most intense cyclones. Using a deterministic framework, we show that when these surface quantities are calculated on an ocean grid that is coarser than the atmosphere, the computed frictional stress is misaligned with wind vectors in individual atmospheric gridmore » cells. This reduces the effective surface drag, and results in more intense cyclones when compared to a model configuration where the ocean and atmosphere are of equivalent resolution. Our results demonstrate that the choice of computation grid for atmosphere–ocean interactions is non-negligible when considering climate extremes at high horizontal resolution, especially when model components are on highly disparate grids.« less

Predictors of Longitudinal Growth in Inhibitory Control in Early Childhood

PubMed Central

Moilanen, Kristin L.; Shaw, Daniel S.; Dishion, Thomas J.; Gardner, Frances; Wilson, Melvin

2009-01-01

In the current study, we examined latent growth in 731 young children’s inhibitory control from ages 2 to 4, and whether demographic characteristics or parenting behaviors were related to initial levels and growth in inhibitory control. As part of an ongoing longitudinal evaluation of the Family Check-Up (FCU), children’s inhibitory control was assessed yearly at ages 2, 3, and 4. Inhibitory control was initially low and increased linearly to age 4. High levels of harsh parenting and male gender were associated with low initial status in inhibitory control. High levels of supportive parenting were associated with faster growth. Extreme family poverty and African American ethnicity were also associated with slower growth. The results highlight parenting as a target for early interventions in contexts of high socioeconomic risk. PMID:20376201

An Assessment of Reliability and Validity of a Rubric for Grading APA-Style Introductions

ERIC Educational Resources Information Center

Stellmack, Mark A.; Konheim-Kalkstein, Yasmine L.; Manor, Julia E.; Massey, Abigail R.; Schmitz, Julie Ann P.

2009-01-01

This article describes the empirical evaluation of the reliability and validity of a grading rubric for grading APA-style introductions of undergraduate students. Levels of interrater agreement and intrarater agreement were not extremely high but were similar to values reported in the literature for comparably structured rubrics. Rank-order…

Remedial Investigation Report, Presidio Main Installation, Presidio of San Francisco. Volume 1: Text

DTIC Science & Technology

1997-01-01

located in the southwestern portion of the PSF, was reportedly a low area which was filled and graded to create a flat surface for a soccer field...1991). Calcium is a macronutrient and is considered nontoxic unless present within a receptors diet at extremely high levels (Bodek et al., 1988

Environmental Forces - Some Esthetic Components.

ERIC Educational Resources Information Center

Severino, D. Alexander

Although our system of mass culture has raised our civilization to an extremely high level of material success and affluence, the fact remains that this system has the inherent flaw of not fully recognizing the esthetic needs of man. To overcome this weakness we need to re-introduce into the system a sizable component of first-hand experience…

Life-threatening emphysematous liver abscess associated with poorly controlled diabetes mellitus: a case report.

PubMed

Takano, Yuichi; Hayashi, Masafumi; Niiya, Fumitaka; Nakanishi, Toru; Hanamura, Shotaro; Asonuma, Kunio; Yamamura, Eiichi; Gomi, Kuniyo; Kuroki, Yuichiro; Maruoka, Naotaka; Inoue, Kazuaki; Nagahama, Masatsugu

2017-03-06

Emphysematous liver abscesses are defined as liver abscesses accompanied by gas formation. The fatality rate is extremely high at 27%, necessitating prompt intensive care. The patient was a 69-year-old Japanese man with type 2 diabetes. He visited the emergency outpatient department for fever and general malaise that had been ongoing for 2 weeks. Abdominal computed tomography revealed an abscess 5 cm in diameter accompanied by gas formation in the right hepatic lobe. Markedly impaired glucose tolerance was observed with a blood sugar level of 571 mg/dL and a glycated hemoglobin level of 14.6%. The patient underwent emergency percutaneous abscess drainage, and intensive care was subsequently initiated. Klebsiella pneumoniae was detected in both the abscess cavity and blood cultures. The drain was removed 3 weeks later, and the patient was discharged. Emphysematous liver abscesses are often observed in patients with poorly controlled diabetes, and the fatality rate is extremely high. Fever and malaise occasionally mask life-threatening infections in diabetic patients, necessitating careful examination.

A new climate index controlling winter wave activity along the Atlantic coast of Europe: The West Europe Pressure Anomaly

NASA Astrophysics Data System (ADS)

Castelle, Bruno; Dodet, Guillaume; Masselink, Gerd; Scott, Tim

2017-02-01

A pioneering and replicable method based on a 66-year numerical weather and wave hindcast is developed to optimize a climate index based on the sea level pressure (SLP) that best explains winter wave height variability along the coast of western Europe, from Portugal to UK (36-52°N). The resulting so-called Western Europe Pressure Anomaly (WEPA) is based on the sea level pressure gradient between the stations Valentia (Ireland) and Santa Cruz de Tenerife (Canary Islands). The WEPA positive phase reflects an intensified and southward shifted SLP difference between the Icelandic low and the Azores high, driving severe storms that funnel high-energy waves toward western Europe southward of 52°N. WEPA outscores by 25-150% the other leading atmospheric modes in explaining winter-averaged significant wave height, and even by a largest amount the winter-averaged extreme wave heights. WEPA is also the only index capturing the 2013/2014 extreme winter that caused widespread coastal erosion and flooding in western Europe.

Exploring societal solidarity in the context of extreme prematurity.

PubMed

Hendriks, Manya J; Bucher, Hans Ulrich; Klein, Sabine D; Streuli, Jürg C; Baumann-Hölzle, Ruth; Fauchère, Jean-Claude

2017-03-21

Extreme prematurity can result in long-term disabilities. Its impact on society is often not taken into account and deemed controversial. Our study examined attitudes of the Swiss population regarding extreme prematurity and people's perspectives regarding the question of solidarity with disabled people. We conducted a nationwide representative anonymous telephone survey with 1210 Swiss residents aged 18 years or older. We asked how people estimate their own personal solidarity, the solidarity of their social environment and the solidarity across the country with disabled persons. Spearman's correlation calculations were used to assess if a correlation exists between solidarity and setting financial limits to intensive care and between solidarity and withholding neonatal intensive care. According to 36.0% of the respondents intensive medical care should not be withheld from extremely preterm infants, even if their chances for an acceptable quality of life were poor. For 28.8%, intensive care should be withheld from these infants, and 26.9% held an intermediate position depending on the situation. A total of 31.5% were against setting a financial limit to treatment of extremely preterm newborns with an uncertain future quality of life, 34.2% were in favour and 26.9% were deliberating. A majority (88.8%) considered their solidarity toward disabled people as substantial; the solidarity of their personal environment and of the society at large was estimated as high by 79.1% and 48.6%, respectively. The Swiss population expressed a high level of solidarity which may alleviate some pressure on parents and health care providers in the decision-making process in neonatal intensive care units. In addition, there was no relationship between solidarity and people's willingness to pay for the care or withholding treatment of extremely preterm babies.

Analysis of present and future potential compound flooding risk along the European coast

NASA Astrophysics Data System (ADS)

Bevacqua, Emanuele; Maraun, Douglas; Voukouvalas, Evangelos; Vousdoukas, Michalis I.; Widmann, Martin; Manning, Colin; Vrac, Mathieu

2017-04-01

The coastal zone is the natural border between the sea and the mainland, and it is constantly under the influence of marine and land-based natural and human-induced pressure. Compound floods are extreme events occurring in coastal areas where the interaction of joint high sea level and large amount of precipitation causes extreme floodings. Typically the risk of flooding in coastal areas is defined analysing either sea level or precipitation driven floodings, however compound floods should be considered to avoid an underestimation of the risk. In the future, the human pressure at the coastal zone is expected to increase, urging for a comprehensive analysis of the compound flooding risk under different climate change scenarios. In this study we introduce the concept of "potential risk" as we investigate how often large amount of precipitation and high sea level may co-occur, and not the effective impact due to the interaction of these two hazards. The effective risk of compound flooding in a specific place depends also on the local orography and on the existing protections. The estimation of the potential risk of compound flooding is useful to individuate places where an effective risk of compound flooding may exist, and where further studies would be useful to get more precise information on the local risk. We estimate the potential risk of compound flooding along the European coastal zone incorporating the ERA-Interim meteorological reanalysis for the past and present state, and the future projections from two RCP scenarios (namely the RCP4.5 and RCP8.5 scenarios) as derived from 8 CMIP5 models of the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. Sea level data are estimated by forcing the hydrodynamic model Delft3D-Flow with 6-hourly wind and atmospheric pressure fields. Based on sea level (storm surge and astronomical tide) and precipitation joint occurrence analysis, a map of the potential compound flooding risk along the European coast is proposed and critical places with high potential risk are identified. For these critical places, we plan to asses the potential compound flood risk driven by coinciding extreme values of sea level and river discharge. Finally, we analyse the atmospheric large scale processes that lead to compound floods and their variation under future climate change scenarios.

An operational-oriented approach to the assessment of low probability seismic ground motions for critical infrastructures

NASA Astrophysics Data System (ADS)

Garcia-Fernandez, Mariano; Assatourians, Karen; Jimenez, Maria-Jose

2018-01-01

Extreme natural hazard events have the potential to cause significant disruption to critical infrastructure (CI) networks. Among them, earthquakes represent a major threat as sudden-onset events with limited, if any, capability of forecast, and high damage potential. In recent years, the increased exposure of interdependent systems has heightened concern, motivating the need for a framework for the management of these increased hazards. The seismic performance level and resilience of existing non-nuclear CIs can be analyzed by identifying the ground motion input values leading to failure of selected key elements. Main interest focuses on the ground motions exceeding the original design values, which should correspond to low probability occurrence. A seismic hazard methodology has been specifically developed to consider low-probability ground motions affecting elongated CI networks. The approach is based on Monte Carlo simulation, which allows for building long-duration synthetic earthquake catalogs to derive low-probability amplitudes. This approach does not affect the mean hazard values and allows obtaining a representation of maximum amplitudes that follow a general extreme-value distribution. This facilitates the analysis of the occurrence of extremes, i.e., very low probability of exceedance from unlikely combinations, for the development of, e.g., stress tests, among other applications. Following this methodology, extreme ground-motion scenarios have been developed for selected combinations of modeling inputs including seismic activity models (source model and magnitude-recurrence relationship), ground motion prediction equations (GMPE), hazard levels, and fractiles of extreme ground motion. The different results provide an overview of the effects of different hazard modeling inputs on the generated extreme motion hazard scenarios. This approach to seismic hazard is at the core of the risk analysis procedure developed and applied to European CI transport networks within the framework of the European-funded INFRARISK project. Such an operational seismic hazard framework can be used to provide insight in a timely manner to make informed risk management or regulating further decisions on the required level of detail or on the adoption of measures, the cost of which can be balanced against the benefits of the measures in question.

Recovery from hip fracture in eight areas of function.

PubMed

Magaziner, J; Hawkes, W; Hebel, J R; Zimmerman, S I; Fox, K M; Dolan, M; Felsenthal, G; Kenzora, J

2000-09-01

This report describes changes in eight areas of functioning after a hip fracture, identifies the point at which maximal levels of recovery are reached in each area, and evaluates the sequence of recuperation across multiple functional domains. METHODS. Community-residing hip fracture patients (n = 674) admitted to eight hospitals in Baltimore, Maryland, 1990-1991 were followed prospectively for 2 years from the time of hospitalization. Eight areas of function (i.e., upper and lower extremity physical and instrumental activities of daily living; gait and balance; social, cognitive, and affective function) were measured by personal interview and direct observation during hospitalization at 2, 6, 12, 18, and 24 months. Levels of recovery are described in each area, and time to reach maximal recovery was estimated using Generalized Estimating Equations and longitudinal data. Most areas of functioning showed progressive lessening of dependence over the first postfracture year, with different levels of recovery and time to maximum levels observed for each area. New dependency in physical and instrumental tasks for those not requiring equipment or human assistance prefracture ranged from as low as 20.3% for putting on pants to as high as 89.9% for climbing five stairs. Recuperation times were specific to area of function, ranging from approximately 4 months for depressive symptoms (3.9 months), upper extremity function (4.3 months), and cognition (4.4 months) to almost a year for lower extremity function (11.2 months). Functional disability following hip fracture is significant, patterns of recovery differ by area of function, and there appears to be an orderly sequence by which areas of function reach their maximal levels.

B-2 Extremely High Frequency SATCOM and Computer Increment 1 (B-2 EHF Inc 1)

DTIC Science & Technology

2015-12-01

Confidence Level Confidence Level of cost estimate for current APB: 55% This APB reflects cost and funding data based on the B-2 EHF Increment I SCP...This cost estimate was quantified at the Mean (~55%) confidence level . Total Quantity Quantity SAR Baseline Production Estimate Current APB...Production Estimate Econ Qty Sch Eng Est Oth Spt Total 33.624 -0.350 1.381 0.375 0.000 -6.075 0.000 -0.620 -5.289 28.335 Current SAR Baseline to Current

Phencyclidine-induced malignant hyperthermia causing submassive liver necrosis.

PubMed

Armen, R; Kanel, G; Reynolds, T

1984-07-01

This report describes three male patients arrested for aggressive and combative behavior, characteristic of phencyclidine intoxication, in whom severe hyperthermia, respiratory failure, and coma developed. Two days after the malignant hyperthermic event, serum transaminase levels rose acutely to extremely high levels with concomitant elevations in bilirubin levels and a fall in prothrombin activity. Liver biopsy specimens in two patients showed marked perivenular necrosis and collapse. No specific treatment was directed at the phencyclidine intoxication. Two of the three patients survived. Submassive liver necrosis caused by malignant hyperthermia is an unusual complication of phencyclidine abuse.

Extreme hydrometeorological events in the Peruvian Central Andes during austral summer and their relationship with the large-scale circulation

NASA Astrophysics Data System (ADS)

Sulca, Juan C.

In this Master's dissertation, atmospheric circulation patterns associated with extreme hydrometeorological events in the Mantaro Basin, Peruvian Central Andes, and their teleconnections during the austral summer (December-January-February-March) are addressed. Extreme rainfall events in the Mantaro basin are related to variations of the large-scale circulation as indicated by the changing strength of the Bolivian High-Nordeste Low (BH-NL) system. Dry (wet) spells are associated with a weakening (strengthening) of the BH-NL system and reduced (enhanced) influx of moist air from the lowlands to the east due to strengthened westerly (easterly) wind anomalies at mid- and upper-tropospheric levels. At the same time extreme rainfall events of the opposite sign occur over northeastern Brazil (NEB) due to enhanced (inhibited) convective activity in conjunction with a strengthened (weakened) Nordeste Low. Cold episodes in the Mantaro Basin are grouped in three types: weak, strong and extraordinary cold episodes. Weak and strong cold episodes in the MB are mainly associated with a weakening of the BH-NL system due to tropical-extratropical interactions. Both types of cold episodes are associated with westerly wind anomalies at mid- and upper-tropospheric levels aloft the Peruvian Central Andes, which inhibit the influx of humid air masses from the lowlands to the east and hence limit the potential for development of convective cloud cover. The resulting clear sky conditions cause nighttime temperatures to drop, leading to cold extremes below the 10-percentile. Extraordinary cold episodes in the MB are associated with cold and dry polar air advection at all tropospheric levels toward the central Peruvian Andes. Therefore, weak and strong cold episodes in the MB appear to be caused by radiative cooling associated with reduced cloudiness, rather than cold air advection, while the latter plays an important role for extraordinary cold episodes only.

Understanding risks in the light of uncertainty: low-probability, high-impact coastal events in cities

NASA Astrophysics Data System (ADS)

Abadie, Luis Maria; Galarraga, Ibon; Sainz de Murieta, Elisa

2017-01-01

A quantification of present and future mean annual losses due to extreme coastal events can be crucial for adequate decision making on adaptation to climate change in coastal areas around the globe. However, this approach is limited when uncertainty needs to be accounted for. In this paper, we assess coastal flood risk from sea-level rise and extreme events in 120 major cities around the world using an alternative stochastic approach that accounts for uncertainty. Probability distributions of future relative (local) sea-level rise have been used for each city, under three IPPC emission scenarios, RCP 2.6, 4.5 and 8.5. The approach allows a continuous stochastic function to be built to assess yearly evolution of damages from 2030 to 2100. Additionally, we present two risk measures that put low-probability, high-damage events in the spotlight: the Value at Risk (VaR) and the Expected Shortfall (ES), which enable the damages to be estimated when a certain risk level is exceeded. This level of acceptable risk can be defined involving different stakeholders to guide progressive adaptation strategies. The method presented here is new in the field of economics of adaptation and offers a much broader picture of the challenges related to dealing with climate impacts. Furthermore, it can be applied to assess not only adaptation needs but also to put adaptation into a timeframe in each city.

Genomic instability in cancer: Teetering on the limit of tolerance

PubMed Central

Andor, Noemi; Maley, Carlo C.; Ji, Hanlee P.

2017-01-01

Cancer genomic instability contributes to the phenomenon of intratumoral genetic heterogeneity, provides the genetic diversity required for natural selection and enables the extensive phenotypic diversity that is frequently observed among patients. Genomic instability has previously been associated with poor prognosis. However, we have evidence that for solid tumors of epithelial origin, extreme levels of genomic instability, where more than 75% of the genome is subject to somatic copy number alterations, are associated with a potentially better prognosis compared to intermediate levels under this threshold. This has been observed in clonal subpopulations of larger size, especially when genomic instability is shared among a limited number of clones. We hypothesize that cancers with extreme levels of genomic instability may be teetering on the brink of a threshold where so much of their genome is adversely altered that cells rarely replicate successfully. Another possibility is that tumors with high levels of genomic instability are more immunogenic than other cancers with a less extensive burden of genetic aberrations. Regardless of the exact mechanism, but hinging on our ability to quantify how a tumor’s burden of genetic aberrations is distributed among coexisting clones – genomic instability has important therapeutic implications. Herein, we explore the possibility that a high genomic instability could be the basis for a tumor’s sensitivity to DNA damaging therapies. We primarily focus on studies of epithelial-derived solid tumors. PMID:28432052

Adaptation to metals in widespread and endemic plants.

PubMed Central

Shaw, A J

1994-01-01

Bryophytes, including the mosses, liverworts, and hornworts, occur in a variety of habitats with high concentrations of metals and have other characteristics that are advantageous for studies of metal tolerance. Mosses may evolve genetically specialized, metal-tolerant races less frequently than flowering plants. Some species of mosses appear to have inherently high levels of metal tolerance even in individuals that have not been subjected to natural selection in contaminated environments. Scopelophila cataractae, one of the so-called copper mosses, not only tolerates extremely high concentrations of metals in its substrates, but requires these substrates for optimum growth. This species should be included in mechanistic studies of tolerance at the cellular and molecular levels. PMID:7713025

Climate Change: A New Metric to Measure Changes in the Frequency of Extreme Temperatures using Record Data

NASA Technical Reports Server (NTRS)

Munasinghe, L.; Jun, T.; Rind, D. H.

2012-01-01

Consensus on global warming is the result of multiple and varying lines of evidence, and one key ramification is the increase in frequency of extreme climate events including record high temperatures. Here we develop a metric- called "record equivalent draws" (RED)-based on record high (low) temperature observations, and show that changes in RED approximate changes in the likelihood of extreme high (low) temperatures. Since we also show that this metric is independent of the specifics of the underlying temperature distributions, RED estimates can be aggregated across different climates to provide a genuinely global assessment of climate change. Using data on monthly average temperatures across the global landmass we find that the frequency of extreme high temperatures increased 10-fold between the first three decades of the last century (1900-1929) and the most recent decade (1999-2008). A more disaggregated analysis shows that the increase in frequency of extreme high temperatures is greater in the tropics than in higher latitudes, a pattern that is not indicated by changes in mean temperature. Our RED estimates also suggest concurrent increases in the frequency of both extreme high and extreme low temperatures during 2002-2008, a period when we observe a plateauing of global mean temperature. Using daily extreme temperature observations, we find that the frequency of extreme high temperatures is greater in the daily minimum temperature time-series compared to the daily maximum temperature time-series. There is no such observable difference in the frequency of extreme low temperatures between the daily minimum and daily maximum.

Which Environmental Factors Predict Seasonal Variation in the Coral Health of Acropora digitifera and Acropora spicifera at Ningaloo Reef?

PubMed Central

Hinrichs, Saskia; Patten, Nicole L.; Feng, Ming; Strickland, Daniel; Waite, Anya M.

2013-01-01

The impact of physico-chemical factors on percent coral cover and coral health was examined on a spatial basis for two dominant Acropora species, A. digitifera and A. spicifera, at Ningaloo Reef (north-western Australia) in the southeast Indian Ocean. Coral health was investigated by measuring metabolic indices (RNA/DNA ratio and protein concentration), energy levels (lipid ratio) and autotrophic indices (chlorophyll a (chl a) and zooxanthellae density) at six stations during typical seasons (austral autumn 2010 (March and April), austral winter 2010 (August)) and during an extreme La Niña event in summer 2011 (February). These indices were correlated with 15 physico-chemical factors (measured immediately following coral sampling) to identify predictors for health indices. Variations in metabolic indices (protein concentration and RNA/DNA ratio) for A. spicifera were mainly explained by nitrogen, temperature and zooplankton concentrations under typical conditions, while for A. digitifera, light as well as phytoplankton, in particular picoeukaryotes, were important, possibly due to higher energy requirement for lipid synthesis and storage in A. digitifera. Optimum metabolic values occurred for both Acropora species at 26–28°C when autotrophic indices (chl a and zooxanthellae density) were lowest. The extreme temperature during the La Niña event resulted in a shift of feeding modes, with an increased importance of water column plankton concentrations for metabolic rates of A. digitifera and light and plankton for A. spicifera. Our results suggest that impacts of high sea surface temperatures during extreme events such as La Niña may be mitigated via reduction on metabolic rates in coral host. The high water column plankton concentrations and associated low light levels resulted in a shift towards high symbiont densities, with lower metabolic rates and energy levels than the seasonal norm for the coral host. PMID:23637770

Asymmetrical Responses of Ecosystem Processes to Positive Versus Negative Precipitation Extremes: a Replicated Regression Experimental Approach

NASA Astrophysics Data System (ADS)

Felton, A. J.; Smith, M. D.

2016-12-01

Heightened climatic variability due to atmospheric warming is forecast to increase the frequency and severity of climate extremes. In particular, changes to interannual variability in precipitation, characterized by increases in extreme wet and dry years, are likely to impact virtually all terrestrial ecosystem processes. However, to date experimental approaches have yet to explicitly test how ecosystem processes respond to multiple levels of climatic extremity, limiting our understanding of how ecosystems will respond to forecast increases in the magnitude of climate extremes. Here we report the results of a replicated regression experimental approach, in which we imposed 9 and 11 levels of growing season precipitation amount and extremity in mesic grassland during 2015 and 2016, respectively. Each level corresponded to a specific percentile of the long-term record, which produced a large gradient of soil moisture conditions that ranged from extreme wet to extreme dry. In both 2015 and 2016, asymptotic responses to water availability were observed for soil respiration. This asymmetry was driven in part by transitions between soil moisture versus temperature constraints on respiration as conditions became increasingly dry versus increasingly wet. In 2015, aboveground net primary production (ANPP) exhibited asymmetric responses to precipitation that largely mirrored those of soil respiration. In total, our results suggest that in this mesic ecosystem, these two carbon cycle processes were more sensitive to extreme drought than to extreme wet years. Future work will assess ANPP responses for 2016, soil nutrient supply and physiological responses of the dominant plant species. Future efforts are needed to compare our findings across a diverse array of ecosystem types, and in particular how the timing and magnitude of precipitation events may modify the response of ecosystem processes to increasing magnitudes of precipitation extremes.

Sensitivity of UK butterflies to local climatic extremes: which life stages are most at risk?

PubMed

McDermott Long, Osgur; Warren, Rachel; Price, Jeff; Brereton, Tom M; Botham, Marc S; Franco, Aldina M A

2017-01-01

There is growing recognition as to the importance of extreme climatic events (ECEs) in determining changes in species populations. In fact, it is often the extent of climate variability that determines a population's ability to persist at a given site. This study examined the impact of ECEs on the resident UK butterfly species (n = 41) over a 37-year period. The study investigated the sensitivity of butterflies to four extremes (drought, extreme precipitation, extreme heat and extreme cold), identified at the site level, across each species' life stages. Variations in the vulnerability of butterflies at the site level were also compared based on three life-history traits (voltinism, habitat requirement and range). This is the first study to examine the effects of ECEs at the site level across all life stages of a butterfly, identifying sensitive life stages and unravelling the role life-history traits play in species sensitivity to ECEs. Butterfly population changes were found to be primarily driven by temperature extremes. Extreme heat was detrimental during overwintering periods and beneficial during adult periods and extreme cold had opposite impacts on both of these life stages. Previously undocumented detrimental effects were identified for extreme precipitation during the pupal life stage for univoltine species. Generalists were found to have significantly more negative associations with ECEs than specialists. With future projections of warmer, wetter winters and more severe weather events, UK butterflies could come under severe pressure given the findings of this study. © 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.

Extreme values and the level-crossing problem: An application to the Feller process

NASA Astrophysics Data System (ADS)

Masoliver, Jaume

2014-04-01

We review the question of the extreme values attained by a random process. We relate it to level crossings to one boundary (first-passage problems) as well as to two boundaries (escape problems). The extremes studied are the maximum, the minimum, the maximum absolute value, and the range or span. We specialize in diffusion processes and present detailed results for the Wiener and Feller processes.

Pyramiding genes and alleles for improving energy cane biomass yield

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ming, Ray; Nagai, Chifumi; Yu, Qingyi

The overall goal of this project is to identify genes and gene interaction networks contributed to the extreme segregants with 30 folds biomass yield difference in sugarcane F2 populations. Towards achieving this goal, yield trials of 108 F2 extreme segregants from S. officinarum LA Purple and S. robustum MOL5829 (LM population) were carried out in two locations in three years. A yield trial of the second F2 population from S. officinarum LA Purple and S. spontaneum US56-14-4 (LU population) was installed in the summer of 2014 and the first set of yield component data was collected. For genotyping, transcriptomes frommore » leaves and stalks of 70 extreme segregants of the LM F2 population and 119 individuals of the LU F2 populations were sequenced. The genomes of 91 F1 individuals from the LM populations are being sequenced to construct ultra-high density genetic maps for each of the two parents for both assisting the LA Purple genome assembling and for testing a hypothesis of female restitution. The genomes of 110 F2 individuals from single F1 in the LU population, a different set from the 119 F2 individuals used for transcriptome sequencing, are being sequenced for mapping genes and QTLs affecting biomass yield and for testing a hypothesis of female restitution. Gene expression analysis between extreme segregants of high and low biomass yield showed up-regulation of cellulose synthase, cellulose, and xylan synthase in high biomass yield segregants among 3,274 genes differentially expressed between the two extremes. Our transcriptome results revealed not only the increment of cell wall biosynthesis pathway is essential, but the rapid turnover of certain cell wall polymers as well as carbohydrate partitioning are also important for recycling and energy conservation during rapid cell growth in high biomass sugarcane. Seventeen differentially expressed genes in auxin, one in ethylene and one in gibberellin related signaling and biosynthesis pathways were identified, which could potentially regulate biomass yield. Differentially expressed genes, PIF3 and EIL5, involved in gibberellin and ethylene pathway could play an important role in biomass accumulation. Differential gene expression analysis was also carried out on the LU population. High-biomass yield was mainly determined by assimilation of carbon in source tissues. The high-level expression of fermentative genes in the low-biomass group was likely induced by their low-energy status. The haploid (tetraploid) genome of S. spontanium AP85-441 was sequenced with chromosome level assembly and allele defined annotation. This reference genome along with the upcoming S. officinarum genome will allow us to identify genes and alleles contributed to biomass yield.« less

Extreme events assessment methodology coupling rainfall and tidal levels in the coastal floodplain of the São Paulo North Coast (Brazil) for drainage purposes

NASA Astrophysics Data System (ADS)

Alfredini, P.; Cartacho, D. L.; Arasaki, E.; Rosso, M.; Sousa, W. C., Jr.; Lanzieri, D. R.; Ferreira, J. P. M.

2012-04-01

The Caraguatatuba Coastal Plain is the wider in São Paulo State (Brazil) North Coastline. The Santo Antônio Torrent Catchmenth drains that region with high urban concentration (around 100,000 permanent inhabitants), which may quintuplicate with the turists in the summer period. In the last decade important oil and gas sea reserves were discovered and the facilities for their treatment were located in that region. For that great economic growth scenario it is mandatory to design mitigation risk measures to have the fluvial forcing processes well known, considering the natural hazards. The Santo Antônio catchment has a surface area of 40 km2, heavy rainfall rates (around 3000 mm/year), concentrated mainly in the summer period, producing high fluvial sediment transport capacity, floods and debris-flows. Due to the steep slopes and the altitude (~ 1000 m) of the mountains near the coast, the hydrological orographic effect rapidly condensates the sea humidity and recurrent and intense flood events cause extensive risks and damages to population and infrastructures. Strong debris-flows occur in that region, because rains higher than 300-400 mm per day occur in multi decadal periods. Due to the wind blowing landward the humidity from the sea, also meteorological tides occur in correspondence of high rainfall rates. The aim of this project is to present an extreme hydrological assessment methodology, coupling rainfall rates and tidal levels, to show the impact of climate changes during the last decades. It is also presented the magnitude of the rising meteorological tide coupled with the extreme rainfall events. The data base analysed comprised long term data of rainfall and tidal measurements from 1954 to 2003. The correlations of the two data were divided in five classes of rainfall in mm per day (> 0, > 25, > 50, > 75 and > 100) and estimated the tidal levels for different return periods in years (2, 5, 10, 20, 50, 75 and 100). The comparison of two distint periods (1954 to 1980 and 1981 to 2000) for extreme events typically used for drainage projects (rains higher than 50 mm/day) clearly showed an increasing in tidal levels for the same return period. That trend indicates the importance to mantain a monitoring network in order to avoid the interruption of long term data series. According to that conclusions were evaluated the number of constructions and inhabitants affected in the are prone of that flooding in the next decades.

Will Half a Degree Make a Difference? Robust Projections of Indices of Mean and Extreme Climate in Europe Under 1.5°C, 2°C, and 3°C Global Warming

NASA Astrophysics Data System (ADS)

Dosio, Alessandro; Fischer, Erich M.

2018-01-01

Based on high-resolution models, we investigate the change in climate extremes and impact-relevant indicators over Europe under different levels of global warming. We specifically assess the robustness of the changes and the benefits of limiting warming to 1.5°C instead of 2°C. Compared to 1.5°C world, a further 0.5°C warming results in a robust change of minimum summer temperature indices (mean, Tn10p, and Tn900p) over more than 70% of Europe. Robust changes (more than 0.5°C) in maximum temperature affect smaller areas (usually less than 20%). There is a substantial nonlinear change of fixed-threshold indices, with more than 60% increase of the number of tropical nights over southern Europe and more than 50% decrease in the number of frost days over central Europe. The change in mean precipitation due to 0.5°C warming is mostly nonsignificant at the grid point level, but, locally, it is accompanied by a more marked change in extreme rainfall.

Molecular Eigensolution Symmetry Analysis and Fine Structure

PubMed Central

Harter, William G.; Mitchell, Justin C.

2013-01-01

Spectra of high-symmetry molecules contain fine and superfine level cluster structure related to J-tunneling between hills and valleys on rovibronic energy surfaces (RES). Such graphic visualizations help disentangle multi-level dynamics, selection rules, and state mixing effects including widespread violation of nuclear spin symmetry species. A review of RES analysis compares it to that of potential energy surfaces (PES) used in Born–Oppenheimer approximations. Both take advantage of adiabatic coupling in order to visualize Hamiltonian eigensolutions. RES of symmetric and D2 asymmetric top rank-2-tensor Hamiltonians are compared with Oh spherical top rank-4-tensor fine-structure clusters of 6-fold and 8-fold tunneling multiplets. Then extreme 12-fold and 24-fold multiplets are analyzed by RES plots of higher rank tensor Hamiltonians. Such extreme clustering is rare in fundamental bands but prevalent in hot bands, and analysis of its superfine structure requires more efficient labeling and a more powerful group theory. This is introduced using elementary examples involving two groups of order-6 (C6 and D3~C3v), then applied to families of Oh clusters in SF6 spectra and to extreme clusters. PMID:23344041

An empirical approach to improving tidal predictions using recent real-time tide gauge data

NASA Astrophysics Data System (ADS)

Hibbert, Angela; Royston, Samantha; Horsburgh, Kevin J.; Leach, Harry

2014-05-01

Classical harmonic methods of tidal prediction are often problematic in estuarine environments due to the distortion of tidal fluctuations in shallow water, which results in a disparity between predicted and observed sea levels. This is of particular concern in the Bristol Channel, where the error associated with tidal predictions is potentially greater due to an unusually large tidal range of around 12m. As such predictions are fundamental to the short-term forecasting of High Water (HW) extremes, it is vital that alternative solutions are found. In a pilot study, using a year-long observational sea level record from the Port of Avonmouth in the Bristol Channel, the UK National Tidal and Sea Level Facility (NTSLF) tested the potential for reducing tidal prediction errors, using three alternatives to the Harmonic Method of tidal prediction. The three methods evaluated were (1) the use of Artificial Neural Network (ANN) models, (2) the Species Concordance technique and (3) a simple empirical procedure for correcting Harmonic Method High Water predictions based upon a few recent observations (referred to as the Empirical Correction Method). This latter method was then successfully applied to sea level records from an additional 42 of the 45 tide gauges that comprise the UK Tide Gauge Network. Consequently, it is to be incorporated into the operational systems of the UK Coastal Monitoring and Forecasting Partnership in order to improve short-term sea level predictions for the UK and in particular, the accurate estimation of HW extremes.

Relationship of psychological and physiological parameters during an arctic ski expedition

NASA Astrophysics Data System (ADS)

Bishop, Sheryl L.; Grobler, Lukas C.; SchjØll, Olaf

2001-08-01

Considerable data (primarily physiological) have been collected during expeditions in extreme environments over the last century. Physiological measurements have only recently been examined in association with the emotional or behavioral state of the subject. Establishing this psychophysiological relationship is essential to understanding fully the adaptation of humans to the stresses of extreme environments. This pilot study investigated the simultaneous collection of physiological, psychological and behavioral data from a two-man Greenland expedition in order to model how specific relationships between physiological and psychological adaptation to a polar environment may be identified. The data collected describes changes in adrenal and other hormonal activity and psychological functioning. Levels of cortisol and testosterone were calculated. Factors influencing the plasma profiles of the aforementioned included 24-hour sunlight, high calorific intake of more than 28 000 kJ/day and extreme physical exercise. There was a difference between individual psychological profiles as well as self-report stress and physiological stress.

Taxonomic study of extreme halophilic archaea isolated from the "Salar de Atacama", Chile.

PubMed

Lizama, C; Monteoliva-Sánchez, M; Prado, B; Ramos-Cormenzana, A; Weckesser, J; Campos, V

2001-11-01

A large number of halophilic bacteria were isolated in 1984-1992 from the Atacama Saltern (North of Chile). For this study 82 strains of extreme halophilic archaea were selected. The characterization was performed by using the phenotypic characters including morphological, physiological, biochemical, nutritional and antimicrobial susceptibility test. The results, together with those from reference strains, were subjected to numerical analysis, using the Simple Matching (S(SM)) coefficient and clustered by the unweighted pair group method of association (UPGMA). Fifteen phena were obtained at an 70% similarity level. The results obtained reveal a high diversity among the halophilic archaea isolated. Representative strains from the phena were chosen to determine their DNA base composition and the percentage of DNA-DNA similarity compared to reference strains. The 16S rRNA studies showed that some of these strains constitutes a new taxa of extreme halophilic archaea.

A pseudoleukemic blood differentiation in a 13-year-old child: an extraordinary presentation of Churg-Strauss syndrome.

PubMed

Mutsaers, E R; Witteveen, R; van den Bosch-Ruis, W; Kuijpers, T W; van Houten, M A; van den Berg, J M

2013-03-01

Churg-Strauss syndrome (CSS) is a rare systemic vasculitis of the small- and medium-size vessels. It is mostly seen in elderly patients presenting as de novo asthma, eosinophilia, and vasculitic organ involvement. In childhood, CSS is extremely rare. The course of pediatric CSS is usually severe and often lethal. We present a case of a 13-year-old girl with a short history of asthma, marked eosinophilia, and multiorgan involvement. The extremely high level of blood eosinophilic granulocytes (51.6 × 10(9)/L) prompted a workup for eosinophilic leukemia before the diagnosis CSS could be made. Subsequently, the disease was successfully treated. This case report shows a classical case of childhood CSS, remarkable because of the presence of extreme hypereosinophilia. It underlines the importance of CSS as a life-threatening cause of hypereosinophilia in children.

Common Ice Hockey Injuries and Treatment: A Current Concepts Review.

PubMed

Mosenthal, William; Kim, Michael; Holzshu, Robert; Hanypsiak, Bryan; Athiviraham, Aravind

Injuries are common in ice hockey, a contact sport where players skate at high speeds on a sheet of ice and shoot a vulcanized rubber puck in excess of one hundred miles per hour. This article reviews the diagnoses and treatment of concussions, injuries to the cervical spine, and lower and upper extremities as they pertain to hockey players. Soft tissue injury of the shoulder, acromioclavicular joint separation, glenohumeral joint dislocation, clavicle fractures, metacarpal fractures, and olecranon bursitis are discussed in the upper-extremity section of the article. Lower-extremity injuries reviewed in this article include adductor strain, athletic pubalgia, femoroacetabular impingement, sports hernia, medial collateral and anterior cruciate ligament tears, skate bite, and ankle sprains. This review is intended to aid the sports medicine physician in providing optimal sports-specific care to allow their athlete to return to their preinjury level of performance.

Within-country variation of salt intake assessed via urinary excretion in Japan: a multilevel analysis in all 47 prefectures.

PubMed

Uechi, Ken; Asakura, Keiko; Masayasu, Shizuko; Sasaki, Satoshi

2017-06-01

Salt intake in Japan remains high; therefore, exploring within-country variation in salt intake and its cause is an important step in the establishment of salt reduction strategies. However, no nationwide evaluation of this variation has been conducted by urinalysis. We aimed to clarify whether within-country variation in salt intake exists in Japan after adjusting for individual characteristics. Healthy men (n=1027) and women (n=1046) aged 20-69 years were recruited from all 47 prefectures of Japan. Twenty-four-hour sodium excretion was estimated using three spot urine samples collected on three nonconsecutive days. The study area was categorized into 12 regions defined by the National Health and Nutrition Survey Japan. Within-country variation in sodium excretion was estimated as a population (region)-level variance using a multilevel model with random intercepts, with adjustment for individual biological, socioeconomic and dietary characteristics. Estimated 24 h sodium excretion was 204.8 mmol per day in men and 155.7 mmol per day in women. Sodium excretion was high in the Northeastern region. However, population-level variance was extremely small after adjusting for individual characteristics (0.8 and 2% of overall variance in men and women, respectively) compared with individual-level variance (99.2 and 98% of overall variance in men and women, respectively). Among individual characteristics, greater body mass index, living with a spouse and high miso-soup intake were associated with high sodium excretion in both sexes. Within-country variation in salt intake in Japan was extremely small compared with individual-level variation. Salt reduction strategies for Japan should be comprehensive and should not address the small within-country differences in intake.

Chip Scale Ultra-Stable Clocks: Miniaturized Phonon Trap Timing Units for PNT of CubeSats

NASA Technical Reports Server (NTRS)

Rais-Zadeh, Mina; Altunc, Serhat; Hunter, Roger C.; Petro, Andrew

2016-01-01

The Chip Scale Ultra-Stable Clocks (CSUSC) project aims to provide a superior alternative to current solutions for low size, weight, and power timing devices. Currently available quartz-based clocks have problems adjusting to the high temperature and extreme acceleration found in space applications, especially when scaled down to match small spacecraft size, weight, and power requirements. The CSUSC project aims to utilize dual-mode resonators on an ovenized platform to achieve the exceptional temperature stability required for these systems. The dual-mode architecture utilizes a temperature sensitive and temperature stable mode simultaneously driven on the same device volume to eliminate ovenization error while maintaining extremely high performance. Using this technology it is possible to achieve parts-per-billion (ppb) levels of temperature stability with multiple orders of magnitude smaller size, weight, and power.

An extreme anomaly in stratospheric ozone over Europe in 1940-1942

NASA Astrophysics Data System (ADS)

Brönnimann, S.; Luterbacher, J.; Staehelin, J.; Svendby, T. M.

2004-04-01

Reevaluated historical total ozone data reveal extraordinarily high values over several European sites in 1940-1942, concurrent with extreme climatic anomalies at the Earth's surface. Using historical radiosonde data, reconstructed upper-level fields, and total ozone data from Arosa (Switzerland), Dombås, and Tromsø (Norway), this unusual case of stratosphere-troposphere coupling is analyzed. At Arosa, numerous strong total ozone peaks in all seasons were due to unusually frequent upper troughs over central Europe and related ozone redistribution in the lower stratosphere. At the Norwegian sites, high winter total ozone was most likely caused by major stratospheric warmings in Jan./Feb. 1940, Feb./Mar. 1941, and Feb. 1942. Results demonstrate that the dynamically driven interannual variability of total ozone can be much larger than that estimated based on the past 25-40 years.

G-Equivalent Acceleration Tolerance in the Eutardigrade Species Hypsibius dujardini

NASA Astrophysics Data System (ADS)

Vasanthan, Tarushika; Alejaldre, Lorea; Hider, Jessica; Patel, Shreya; Husain, Nabiha; Umapathisivam, Bavithra; Stone, Jonathon

2017-01-01

Tardigrades are microscopic organisms renowned for their ability to survive extreme environmental conditions. Tardigrade extreme-tolerance research has centered on the ability to withstand desiccation, low and high temperatures, and high hydrostatic pressure and radiation levels. Tardigrade tolerance to hypergravity, however, has yet to be described. We used the eutardigrade species Hypsibius dujardini to investigate short-term tolerance to g-equivalent accelerations (i.e., mimicking g-forces). Data obtained from specimens centrifuged between 3421g and 16,060g for 1 min inclusively reveal tolerance in an acceleration-dependent relation, with lower survivorship and egg production at higher accelerations. This is the first study to demonstrate tardigrade potential for tolerance to hypergravity and describe expected effects on tardigrade survival and reproduction. These findings will prove to be useful in lithopanspermia research (i.e., viable spread in meteoritic rocks).

[Changes in the chromatin structure of lymphoid cells under the influence of low-intensity extremely high-frequency electromagnetic radiation against the background of inflammatory process].

PubMed

Gapeev, A B; Romanova, N A; Chemeris, N K

2011-01-01

Using the alkaline single cell gel electrophoresis technique (comet assay), changes in chromatin structure of peripheral blood leukocytes and peritoneal neutrophils have been studied in mice exposed to low-intensity extremely high-frequency electromagnetic radiation (42.2 GHz, 0.1 mW/cm2, 20 min at 1 h after induction of inflammation) against the background of the systemic inflammatory process. It was revealed that the exposure of mice with the developing inflammation leads to a pronounced decrease in the level of DNA damage to peripheral blood leukocytes and peritoneal neutrophils. It is supposed that the changes in the chromatin structure of lymphoid cells have a genoprotective character in the inflammatory process and can underlie the mechanisms of realization of antiinflammatory effects of the electromagnetic radiation.

Assessing the features of extreme smog in China and the differentiated treatment strategy

NASA Astrophysics Data System (ADS)

Deng, Lu; Zhang, Zhengjun

2018-01-01

Extreme smog can have potentially harmful effects on human health, the economy and daily life. However, the average (mean) values do not provide strategically useful information on the hazard analysis and control of extreme smog. This article investigates China's smog extremes by applying extreme value analysis to hourly PM2.5 data from 2014 to 2016 obtained from monitoring stations across China. By fitting a generalized extreme value (GEV) distribution to exceedances over a station-specific extreme smog level at each monitoring location, all study stations are grouped into eight different categories based on the estimated mean and shape parameter values of fitted GEV distributions. The extreme features characterized by the mean of the fitted extreme value distribution, the maximum frequency and the tail index of extreme smog at each location are analysed. These features can provide useful information for central/local government to conduct differentiated treatments in cities within different categories and conduct similar prevention goals and control strategies among those cities belonging to the same category in a range of areas. Furthermore, hazardous hours, breaking probability and the 1-year return level of each station are demonstrated by category, based on which the future control and reduction targets of extreme smog are proposed for the cities of Beijing, Tianjin and Hebei as an example.

Microstructured snow targets for high energy quasi-monoenergetic proton acceleration

NASA Astrophysics Data System (ADS)

Schleifer, E.; Nahum, E.; Eisenmann, S.; Botton, M.; Baspaly, A.; Pomerantz, I.; Abricht, F.; Branzel, J.; Priebe, G.; Steinke, S.; Andreev, A.; Schnuerer, M.; Sandner, W.; Gordon, D.; Sprangle, P.; Ledingham, K. W. D.; Zigler, A.

2013-05-01

Compact size sources of high energy protons (50-200MeV) are expected to be key technology in a wide range of scientific applications 1-8. One promising approach is the Target Normal Sheath Acceleration (TNSA) scheme 9,10, holding record level of 67MeV protons generated by a peta-Watt laser 11. In general, laser intensity exceeding 1018 W/cm2 is required to produce MeV level protons. Another approach is the Break-Out Afterburner (BOA) scheme which is a more efficient acceleration scheme but requires an extremely clean pulse with contrast ratio of above 10-10. Increasing the energy of the accelerated protons using modest energy laser sources is a very attractive task nowadays. Recently, nano-scale targets were used to accelerate ions 12,13 but no significant enhancement of the accelerated proton energy was measured. Here we report on the generation of up to 20MeV by a modest (5TW) laser system interacting with a microstructured snow target deposited on a Sapphire substrate. This scheme relax also the requirement of high contrast ratio between the pulse and the pre-pulse, where the latter produces the highly structured plasma essential for the interaction process. The plasma near the tip of the snow target is subject to locally enhanced laser intensity with high spatial gradients, and enhanced charge separation is obtained. Electrostatic fields of extremely high intensities are produced, and protons are accelerated to MeV-level energies. PIC simulations of this targets reproduce the experimentally measured energy scaling and predict the generation of 150 MeV protons from laser power of 100TW laser system18.

ENVIRONMENTAL SCIENCE. Profiling risk and sustainability in coastal deltas of the world.

PubMed

Tessler, Z D; Vörösmarty, C J; Grossberg, M; Gladkova, I; Aizenman, H; Syvitski, J P M; Foufoula-Georgiou, E

2015-08-07

Deltas are highly sensitive to increasing risks arising from local human activities, land subsidence, regional water management, global sea-level rise, and climate extremes. We quantified changing flood risk due to extreme events using an integrated set of global environmental, geophysical, and social indicators. Although risks are distributed across all levels of economic development, wealthy countries effectively limit their present-day threat by gross domestic product-enabled infrastructure and coastal defense investments. In an energy-constrained future, such protections will probably prove to be unsustainable, raising relative risks by four to eight times in the Mississippi and Rhine deltas and by one-and-a-half to four times in the Chao Phraya and Yangtze deltas. The current emphasis on short-term solutions for the world's deltas will greatly constrain options for designing sustainable solutions in the long term. Copyright © 2015, American Association for the Advancement of Science.

Run-up parameterization and beach vulnerability assessment on a barrier island: a downscaling approach

NASA Astrophysics Data System (ADS)

Medellín, G.; Brinkkemper, J. A.; Torres-Freyermuth, A.; Appendini, C. M.; Mendoza, E. T.; Salles, P.

2016-01-01

We present a downscaling approach for the study of wave-induced extreme water levels at a location on a barrier island in Yucatán (Mexico). Wave information from a 30-year wave hindcast is validated with in situ measurements at 8 m water depth. The maximum dissimilarity algorithm is employed for the selection of 600 representative cases, encompassing different combinations of wave characteristics and tidal level. The selected cases are propagated from 8 m water depth to the shore using the coupling of a third-generation wave model and a phase-resolving non-hydrostatic nonlinear shallow-water equation model. Extreme wave run-up, R2%, is estimated for the simulated cases and can be further employed to reconstruct the 30-year time series using an interpolation algorithm. Downscaling results show run-up saturation during more energetic wave conditions and modulation owing to tides. The latter suggests that the R2% can be parameterized using a hyperbolic-like formulation with dependency on both wave height and tidal level. The new parametric formulation is in agreement with the downscaling results (r2 = 0.78), allowing a fast calculation of wave-induced extreme water levels at this location. Finally, an assessment of beach vulnerability to wave-induced extreme water levels is conducted at the study area by employing the two approaches (reconstruction/parameterization) and a storm impact scale. The 30-year extreme water level hindcast allows the calculation of beach vulnerability as a function of return periods. It is shown that the downscaling-derived parameterization provides reasonable results as compared with the numerical approach. This methodology can be extended to other locations and can be further improved by incorporating the storm surge contributions to the extreme water level.

Characterizing Microbial Water Quality of Extreme Tide Floodwaters Discharged from an Urbanized Subtropical Beach: Case Study of Miami Beach with Implications for Sea Level Rise and Public Health

NASA Astrophysics Data System (ADS)

Gidley, M. L.

2016-02-01

With the advent of rising sea levels and increasing incidents of extreme tidal flooding events and stormwater flooding events, there is increasing probability of mobilization of land-based sources of pollution (LBSP) from highly urbanized beach environments and potential transport of these contaminants to coastal waters where they may have negative impacts on ecosystems and public health. A case in point is the situation facing the City of Miami Beach, where urban tidal flooding has become routine for extreme tidal events such as King Tide. To deal with the increasing problem of tidal flooding and other potential sources of coastal inundation, the City of Miami Beach has installed a system of floodwater/stormwater pumping stations to collect and discharge such floodwaters. This system appears to control the extent and duration of coastal inundation, however, the floodwater is discharged directly into Biscayne Bay without any treatment , which may potentially carry a variety of pollutants acquired during inundation of this urbanized coast. We report a case study examining the microbial water quality of floodwaters discharged by this pumping system back into Biscayne Bay following the inundation by King Tide floodwaters from September 2014 and 2015. The presence and abundance of both general and host-specific fecal indicating bacteria (FIB), including enterococci and human-host Bacteriodales were measured by traditional culture methods and by molecular microbial source tracking (MST) qPCR methods. While the results from different locations did vary substantially, several discharge samples demonstrated high elevations of fecal indicator bacteria and high levels of human fecal marker by MST. This study suggests that while such flood control measures may improve resiliency of urbanized coastal communities to tidal flooding and/or stormwater, the water quality of such floodwater discharges need to be monitored and potentially treated to mediate the transport of LBSP contaminants to the coastal zone, thus better protecting both ecosystem and public health in an era of sea level rise and more frequent inundation events.

Estimating the impact of extreme climatic events on riverine sediment transport: new tools and methods

NASA Astrophysics Data System (ADS)

Lajeunesse, E.; Delacourt, C.; Allemand, P.; Limare, A.; Dessert, C.; Ammann, J.; Grandjean, P.

2010-12-01

A series of recent works have underlined that the flux of material exported outside of a watershed is dramatically increased during extreme climatic events, such as storms, tropical cyclones and hurricanes [Dadson et al., 2003 and 2004; Hilton et al., 2008]. Indeed the exceptionally high rainfall rates reached during these events trigger runoff and landsliding which destabilize slopes and accumulate a significant amount of sediments in flooded rivers. This observation raises the question of the control that extreme climatic events might exert on the denudation rate and the morphology of watersheds. Addressing this questions requires to measure sediment transport in flooded rivers. However most conventional sediment monitoring technics rely on manned operated measurements which cannot be performed during extreme climatic events. Monitoring riverine sediment transport during extreme climatic events remains therefore a challenging issue because of the lack of instruments and methodologies adapted to such extreme conditions. In this paper, we present a new methodology aimed at estimating the impact of extreme events on sediment transport in rivers. Our approach relies on the development of two instruments. The first one is an in-situ optical instrument, based on a LISST-25X sensor, capable of measuring both the water level and the concentration of suspended matter in rivers with a time step going from one measurement every hour at low flow to one measurement every 2 minutes during a flood. The second instrument is a remote controlled drone helicopter used to acquire high resolution stereophotogrammetric images of river beds used to compute DEMs and to estimate how flash floods impact the granulometry and the morphology of the river. These two instruments were developed and tested during a 1.5 years field survey performed from june 2007 to january 2009 on the Capesterre river located on Basse-Terre island (Guadeloupe archipelago, Lesser Antilles Arc).

The Relationship Between Pitching Mechanics and Injury: A Review of Current Concepts

PubMed Central

Chalmers, Peter N.; Wimmer, Markus A.; Verma, Nikhil N.; Cole, Brian J.; Romeo, Anthony A.; Cvetanovich, Gregory L.; Pearl, Michael L.; Chalmers, Peter N.; Wimmer, Markus A.; Verma, Nikhil N.; Cole, Brian J.; Romeo, Anthony A.; Cvetanovich, Gregory L.; Pearl, Michael L.

2017-01-01

Context: The overhand pitch is one of the fastest known human motions and places enormous forces and torques on the upper extremity. Shoulder and elbow pain and injury are common in high-level pitchers. A large body of research has been conducted to understand the pitching motion. Evidence Acquisition: A comprehensive review of the literature was performed to gain a full understanding of all currently available biomechanical and clinical evidence surrounding pitching motion analysis. These motion analysis studies use video motion analysis, electromyography, electromagnetic sensors, and markered motion analysis. This review includes studies performed between 1983 and 2016. Study Design: Clinical review. Level of Evidence: Level 5. Results: The pitching motion is a kinetic chain, in which the force generated by the large muscles of the lower extremity and trunk during the wind-up and stride phases are transferred to the ball through the shoulder and elbow during the cocking and acceleration phases. Numerous kinematic factors have been identified that increase shoulder and elbow torques, which are linked to increased risk for injury. Conclusion: Altered knee flexion at ball release, early trunk rotation, loss of shoulder rotational range of motion, increased elbow flexion at ball release, high pitch velocity, and increased pitcher fatigue may increase shoulder and elbow torques and risk for injury. PMID:28107113

Deep-Dive Targeted Quantification for Ultrasensitive Analysis of Proteins in Nondepleted Human Blood Plasma/Serum and Tissues

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nie, Song; Shi, Tujin; Fillmore, Thomas L.

Mass spectrometry-based targeted proteomics (e.g., selected reaction monitoring, SRM) is emerging as an attractive alternative to immunoassays for protein quantification. Recently we have made significant progress in SRM sensitivity for enabling quantification of low ng/mL to sub-ng/mL level proteins in nondepleted human blood plasma/serum without affinity enrichment. However, precise quantification of extremely low abundant but biologically important proteins (e.g., ≤100 pg/mL in blood plasma/serum) using targeted proteomics approaches still remains challenging. To address this need, we have developed an antibody-independent Deep-Dive SRM (DD-SRM) approach that capitalizes on multidimensional high-resolution reversed-phase liquid chromatography (LC) separation for target peptide enrichment combined withmore » precise selection of target peptide fractions of interest, significantly improving SRM sensitivity by ~5 orders of magnitude when compared to conventional LC-SRM. Application of DD-SRM to human serum and tissue has been demonstrated to enable precise quantification of endogenous proteins at ~10 pg/mL level in nondepleted serum and at <10 copies per cell level in tissue. Thus, DD-SRM holds great promise for precisely measuring extremely low abundance proteins or protein modifications, especially when high-quality antibody is not available.« less

Effect of mobile usage on serum melatonin levels among medical students.

PubMed

Shrivastava, Abha; Saxena, Yogesh

2014-01-01

Exposure to extremely low frequency (ELF) electromagnetic radiations from mobile phones may affect the circadian rhythm of melatonin in mobile users. The study was designed with objective to evaluate the influence of mobile phone on circadian rhythm of melatonin and to find the association if any between the hours of mobile usage with serum melatonin levels. All the volunteers medical students using mobiles for > 2 hrs/day were included in high users group and volunteers who used mobile for ≤ 2 hrs where included in low users group. Both high and low users volunteers were sampled three times in the same day (Morning-3-4 am, Noon 1-2 pm, Evening-5-6 pm) for estimation of serum melatonin levels: Comparsion of sernum melatonin levels in high users and low users were done by Mann Whitney "U" Test. Reduced morning melatonin levels (3-4 am) was observed in high users (> 2 hrs/day) i.e high users had a disturbed melatonin circadian rhythm.There was a negative correlation between melatonin secretion and hours of mobile usages.

Epidemic failure detection and consensus for extreme parallelism

DOE PAGES

Katti, Amogh; Di Fatta, Giuseppe; Naughton, Thomas; ...

2017-02-01

Future extreme-scale high-performance computing systems will be required to work under frequent component failures. The MPI Forum s User Level Failure Mitigation proposal has introduced an operation, MPI Comm shrink, to synchronize the alive processes on the list of failed processes, so that applications can continue to execute even in the presence of failures by adopting algorithm-based fault tolerance techniques. This MPI Comm shrink operation requires a failure detection and consensus algorithm. This paper presents three novel failure detection and consensus algorithms using Gossiping. The proposed algorithms were implemented and tested using the Extreme-scale Simulator. The results show that inmore » all algorithms the number of Gossip cycles to achieve global consensus scales logarithmically with system size. The second algorithm also shows better scalability in terms of memory and network bandwidth usage and a perfect synchronization in achieving global consensus. The third approach is a three-phase distributed failure detection and consensus algorithm and provides consistency guarantees even in very large and extreme-scale systems while at the same time being memory and bandwidth efficient.« less

Persistence analysis of extreme CO, NO2 and O3 concentrations in ambient air of Delhi

NASA Astrophysics Data System (ADS)

Chelani, Asha B.

2012-05-01

Persistence analysis of air pollutant concentration and corresponding exceedance time series is carried out to examine for temporal evolution. For this purpose, air pollutant concentrations, namely, CO, NO2 and O3 observed during 2000-2009 at a traffic site in Delhi are analyzed using detrended fluctuation analysis. Two types of extreme values are analyzed; exceeded concentrations to a threshold provided by national pollution controlling agency and time interval between two exceedances. The time series of three pollutants is observed to possess persistence property whereas the extreme value time series of only primary pollutant concentrations is found to be persistent. Two time scaling regions are observed to be significant in extreme time series of CO and NO2, mainly attributed to implementation of CNG in vehicles. The presence of persistence in three pollutant concentration time series is linked to the property of self-organized criticality. The observed persistence in the time interval between two exceeded levels is a matter of concern as persistent high concentrations can trigger health problems.

High current density ion beam obtained by a transition to a highly focused state in extremely low-energy region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirano, Y., E-mail: y.hirano@aist.go.jp, E-mail: hirano.yoichi@phys.cst.nihon-u.ac.jp; College of Science and Technologies, Nihon University, Chiyodaku, Tokyo 101-0897; Kiyama, S.

2015-11-15

A high current density (≈3 mA/cm{sup 2}) hydrogen ion beam source operating in an extremely low-energy region (E{sub ib} ≈ 150–200 eV) has been realized by using a transition to a highly focused state, where the beam is extracted from the ion source chamber through three concave electrodes with nominal focal lengths of ≈350 mm. The transition occurs when the beam energy exceeds a threshold value between 145 and 170 eV. Low-level hysteresis is observed in the transition when E{sub ib} is being reduced. The radial profiles of the ion beam current density and the low temperature ion current densitymore » can be obtained separately using a Faraday cup with a grid in front. The measured profiles confirm that more than a half of the extracted beam ions reaches the target plate with a good focusing profile with a full width at half maximum of ≈3 cm. Estimation of the particle balances in beam ions, the slow ions, and the electrons indicates the possibility that the secondary electron emission from the target plate and electron impact ionization of hydrogen may play roles as particle sources in this extremely low-energy beam after the compensation of beam ion space charge.« less

Integrated nanomaterials for extreme thermal management: a perspective for aerospace applications

NASA Astrophysics Data System (ADS)

Barako, Michael T.; Gambin, Vincent; Tice, Jesse

2018-04-01

Nanomaterials will play a disruptive role in next-generation thermal management for high power electronics in aerospace platforms. These high power and high frequency devices have been experiencing a paradigm shift toward designs that favor extreme integration and compaction. The reduction in form factor amplifies the intensity of the thermal loads and imposes extreme requirements on the thermal management architecture for reliable operation. In this perspective, we introduce the opportunities and challenges enabled by rationally integrating nanomaterials along the entire thermal resistance chain, beginning at the high heat flux source up to the system-level heat rejection. Using gallium nitride radio frequency devices as a case study, we employ a combination of viewpoints comprised of original research, academic literature, and industry adoption of emerging nanotechnologies being used to construct advanced thermal management architectures. We consider the benefits and challenges for nanomaterials along the entire thermal pathway from synthetic diamond and on-chip microfluidics at the heat source to vertically-aligned copper nanowires and nanoporous media along the heat rejection pathway. We then propose a vision for a materials-by-design approach to the rational engineering of complex nanostructures to achieve tunable property combinations on demand. These strategies offer a snapshot of the opportunities enabled by the rational design of nanomaterials to mitigate thermal constraints and approach the limits of performance in complex aerospace electronics.

Integrated nanomaterials for extreme thermal management: a perspective for aerospace applications.

PubMed

Barako, Michael T; Gambin, Vincent; Tice, Jesse

2018-04-02

Nanomaterials will play a disruptive role in next-generation thermal management for high power electronics in aerospace platforms. These high power and high frequency devices have been experiencing a paradigm shift toward designs that favor extreme integration and compaction. The reduction in form factor amplifies the intensity of the thermal loads and imposes extreme requirements on the thermal management architecture for reliable operation. In this perspective, we introduce the opportunities and challenges enabled by rationally integrating nanomaterials along the entire thermal resistance chain, beginning at the high heat flux source up to the system-level heat rejection. Using gallium nitride radio frequency devices as a case study, we employ a combination of viewpoints comprised of original research, academic literature, and industry adoption of emerging nanotechnologies being used to construct advanced thermal management architectures. We consider the benefits and challenges for nanomaterials along the entire thermal pathway from synthetic diamond and on-chip microfluidics at the heat source to vertically-aligned copper nanowires and nanoporous media along the heat rejection pathway. We then propose a vision for a materials-by-design approach to the rational engineering of complex nanostructures to achieve tunable property combinations on demand. These strategies offer a snapshot of the opportunities enabled by the rational design of nanomaterials to mitigate thermal constraints and approach the limits of performance in complex aerospace electronics.

Consequences of the river valley bottom transformation after extreme flood (on the example of the Niida River, Japan)

NASA Astrophysics Data System (ADS)

Botavin, D.; Golosov, V.; Konoplev, A.; Wakiyama, Y.

2018-01-01

Detailed study of different sections of floodplain was undertaken in the Niida River basin (Fukushima Prefecture) after an extreme flood event which occurred in the middle of September 2015. The upstream part of the basin is located in the area with very high level of radionuclide contamination after the accident at Fukushima Dai-ichi NPP. Field and GIS methods were used, including direct measurement of the depth of fresh sediment and its area, with soil descriptions for the typical floodplain sections, measurement of dose rates, interpretation of space images for a few time intervals (before and after flood event) with the following evaluation of spatial changes in deposition for different floodplain sections. In addition, results of quantitative assessment of sedimentation rates and soil radionuclide contamination were applied for understanding the effect of extreme flood on alluvial soils of the different sections. It was established that the maximum sedimentation rates (20-50 cm/event) occurred in the middle part of the lower reach of the Niida River and in some locations of the upper reaches. Dose rates had reduced considerably for all the areas with high sedimentation because the top soil layers with high radionuclide contamination were buried under fresh sediments produced mostly due to bank erosion and mass movements.

[Evidence of work-related musculo-skeletal disorders of the upper extremities and current methods of risk assessment: can Charlie Chaplin give us any suggestions in "modern times"].

PubMed

Apostoli, P; Sala, Emma

2009-01-01

in some sequences of the film "Modern Times" Chaplin is clearly involved in activities at high risk for work-related musculo-skeletal disorders of the upper extremities (UEWMSDs), but evidence and perception of any complaint are not evident. To evaluate the extent of the biomechanical risk using current risk assessment methods and discuss the possible reasons for lack of complaints. we made an analysis using six of the current methods for ergonomic risk assessment (State of Washington, check list OCRA, HAL by ACGIH, RULA Strain Index, OREGE). All the methods applied demonstrated high-to-very high levels of biomechanical risk for the upper extremities, with evident psychic effects but without apparent musculo-skeletal disorders. The discrepancy between evident psychological disorders ad apparent absence of UEWMSDs are discussed as being due to either: an artistic choice by Charlie Chaplin who focused on the aspects thought to be more immediately and easily comic; the short duration of the physical load exertion; or because of a different perception of muscular work and fatigue that was also typical until the 1970's and 1980's, which also confirmed the principles and practices of our preventive and medical disciplines at that time.

Millimeter waves or extremely high frequency electromagnetic fields in the environment: what are their effects on bacteria?

PubMed

Soghomonyan, Diana; Trchounian, Karen; Trchounian, Armen

2016-06-01

Millimeter waves (MMW) or electromagnetic fields of extremely high frequencies at low intensity is a new environmental factor, the level of which is increased as technology advance. It is of interest that bacteria and other cells might communicate with each other by electromagnetic field of sub-extremely high frequency range. These MMW affected Escherichia coli and many other bacteria, mainly depressing their growth and changing properties and activity. These effects were non-thermal and depended on different factors. The significant cellular targets for MMW effects could be water, cell plasma membrane, and genome. The model for the MMW interaction with bacteria is suggested; a role of the membrane-associated proton FOF1-ATPase, key enzyme of bioenergetic relevance, is proposed. The consequences of MMW interaction with bacteria are the changes in their sensitivity to different biologically active chemicals, including antibiotics. Novel data on MMW effects on bacteria and their sensitivity to different antibiotics are presented and discussed; the combined action of MMW and antibiotics resulted with more strong effects. These effects are of significance for understanding changed metabolic pathways and distinguish role of bacteria in environment; they might be leading to antibiotic resistance in bacteria. The effects might have applications in the development of technique, therapeutic practices, and food protection technology.

Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations

PubMed Central

Kim, Dae-Hyeong; Song, Jizhou; Choi, Won Mook; Kim, Hoon-Sik; Kim, Rak-Hwan; Liu, Zhuangjian; Huang, Yonggang Y.; Hwang, Keh-Chih; Zhang, Yong-wei; Rogers, John A.

2008-01-01

Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable new biomedical devices and other applications whose requirements are impossible to satisfy with conventional wafer-based technologies or even with those that offer simple bendability. This article introduces materials and mechanical design strategies for classes of electronic circuits that offer extremely high stretchability, enabling them to accommodate even demanding configurations such as corkscrew twists with tight pitch (e.g., 90° in ≈1 cm) and linear stretching to “rubber-band” levels of strain (e.g., up to ≈140%). The use of single crystalline silicon nanomaterials for the semiconductor provides performance in stretchable complementary metal-oxide-semiconductor (CMOS) integrated circuits approaching that of conventional devices with comparable feature sizes formed on silicon wafers. Comprehensive theoretical studies of the mechanics reveal the way in which the structural designs enable these extreme mechanical properties without fracturing the intrinsically brittle active materials or even inducing significant changes in their electrical properties. The results, as demonstrated through electrical measurements of arrays of transistors, CMOS inverters, ring oscillators, and differential amplifiers, suggest a valuable route to high-performance stretchable electronics. PMID:19015528

Down to Earth with a hazard from space: Mapping geoelectric amplitudes for extreme levels of magnetic-storm disturbance

NASA Astrophysics Data System (ADS)

Love, J. J.

2016-12-01

Magnetic-storm induction of geoelectric fields in the Earth's electrically conducting crust, lithosphere, mantle, and ocean can interfere with the operations of electric-power grid systems. The future occurrence of an extremely intense magnetic storm might even result in continental-scale failure of electric-power distribution. Such an event would entail significant deleterious consequence for the economy and international security. Building on a project established by the President's National Science and Technology Council and the Office of Science and Technology Policy for assessing space-weather induction hazards, we develop a series of geoelectric hazard maps. These are constructed using an empirical parameterization of induction: local estimates of Earth-surface impedance, obtained from EarthScope and USGS magnetotelluric survey data, are convolved with latitude-dependent statistical maps of extreme-value geomagnetic activity, obtained from decades magnetic observatory data. Geoelectric hazard maps are constructed for both north-south and east-west geomagnetic variation, and for both 240-s and 1200-s sinusoidal variation -- periods of interest to the power-grid industry. The maps cover about half of the continental United States. They depict the threshold level that geoelectric amplitude can be expected to exceed, on average, once per century at discrete geographic sites in response to extreme-intensity geomagnetic activity. Of the regions where magnetotelluric data are available, the greatest induction hazards are found in Minnesota, Wisconsin, and Iowa - this being the result of both high-latitude geomagntic activity and complex subsurface conductivity structure. At some sites in the continental United States, once-per-century geoelectric amplitudes can exceed the 1.7 V/km realized in Quebec during the March 1989 storm. This work highlights the importance of geophysical surveys and ground-level monitoring data for assessing space-weather induction hazards.

Managing air and water quality in the face of uncertain futures: perspectives, perceptions, reported action, and needs for climate adaptation at the local level

NASA Astrophysics Data System (ADS)

Bedsworth, L. W.; Ekstrom, J.

2017-12-01

As the climate continues to shift, projections show amplified and more frequent extreme events, including coastal and inland flooding, wildfires, prolonged droughts, and heatwaves. Vital public goods, both air quality and water quality, can be critically affected by such extreme events. Climate change will make it increasingly difficult for managers to achieve public health targets for air and water quality. Successfully preparing governance structures developed to maintain and improve air and water quality may benefit from preventative strategies to avoid public health impacts and costs of climate change locally. Perceptions of climate change and its risks, actions taken so far, and perceived barriers to adaptation give insight into the needs of managers for preparing for climate change impacts. This paper compares results of two surveys that looked at local level management of air quality and water quality in California. Air quality managers consistently reported to recognize the risks of climate change on their sector, where water quality managers' perceptions varied between no concern to high concern. We explore the differences in governance, capacity influence the ill-defined responsibility and assumed roles of water and air districts in adaptation to extreme events increasing with climate change. The chain and network of managing air quality is compared with that of water quality - laying out similarities and differences. Then we compare how the survey respondents differed in terms of extreme weather-influenced threats to environmental quality. We end with a discussion of responsibility - where in the chain of managing these life-critical ecosystem services, is the need greatest for adapting to climate change and what does this mean for the other levels in the chain beyond the local management.

Hydrological Controls on Macrophyte Productivity in the Amazon Floodplain Wetlands

NASA Astrophysics Data System (ADS)

Silva, T. S.; Novo, E. M.; Melack, J. M.

2013-05-01

The Amazon River floodplain is an important source of atmospheric CO2 and CH4, but the relative contribution of allochthonous and autochthonous sources to floodplain emissions is still uncertain. Macrophytes comprise an important carbon source, growing during both low and high water conditions, and averaging 5,000 g.m-2.yr-1 in dry weight. The controls exerted by the annual flooding on macrophyte productivity result from two opposing mechanisms: the "horizontal expansion" of plant stands during low water levels and the stem elongation ("vertical growth") promoted by rising water levels. As studies suggest more frequent and intense droughts for the Amazon, determining how these mechanisms interact to control macrophyte net primary productivity (NPP) can lead to a better understanding of the effects of extreme hydrological conditions on autochthonous carbon fixation in the Amazon floodplain. Our study combines remote sensing estimates of macrophyte cover, in situ measurements of macrophyte biomass, historical water level records, and statistical modeling and simulation to answer 1) how plant horizontal expansion and vertical growth respond to inter-annual flooding variability, 2) how these responses modulate annual NPP, and 3) how climatic changes will affect the contribution of macrophytes to the carbon budget of the Amazon floodplain. Biomass data was collected along a stretch of the Lower Amazon Floodplain, at monthly intervals in 2004, and a time series of Radarsat-1 and EOS-MODIS images was acquired for the same area for the 2003-2005 period. Daily river stage data was acquired from the Brazilian National Water Agency (ANA) for the Óbidos station, covering the 1970 - 2011 period. Macrophyte cover was estimated for each available image in the series, using a multitemporal object-based image analysis algorithm. Empirical regression models were used to model the relationship between flood levels and both plant biomass and cover area, and combined into a semi-empirical growth model. Annual NPP was then predicted from daily biomass increments, spanning the 42-year hydrological data record. Resulting macrophyte cover maps had overall accuracies between 60% and 90%, and macrophyte cover area increased fourfold between high and low water seasons. Simulated NPP had marked variability, ranging from 1.06 (0.68, 1.70) Tg C yr-1 in 1980 to 1.63 (1.03, 2.63) Tg C yr-1 in 2009 for the entire mapped area.Values between parentheses show the 95% prediciton limits. Vertical growth was sensitive to extreme floods, but not to severe droughts, while horizontal expansion was affected by both extremely low and high water levels. The simulation revealed a complex pattern of interaction between the two components, indicating that extreme floods may result in larger increases in carbon fixation than extreme droughts. However, the results also suggested that overall flooding amplitude was positively correlated with simulated NPP values (r = 0.63, p > 0.001). An increasing trend in flood amplitude was observed in the hydrological record, which led to a small increase in annual NPP , of approximately 0.0008 TgC.yr-1 for the entire study region.

Atmospheric Moisture Budget and Spatial Resolution Dependence of Precipitation Extremes in Aquaplanet Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Qing; Leung, Lai-Yung R.; Rauscher, Sara

This study investigates the resolution dependency of precipitation extremes in an aqua-planet framework. Strong resolution dependency of precipitation extremes is seen over both tropics and extra-tropics, and the magnitude of this dependency also varies with dynamical cores. Moisture budget analyses based on aqua-planet simulations with the Community Atmosphere Model (CAM) using the Model for Prediction Across Scales (MPAS) and High Order Method Modeling Environment (HOMME) dynamical cores but the same physics parameterizations suggest that during precipitation extremes moisture supply for surface precipitation is mainly derived from advective moisture convergence. The resolution dependency of precipitation extremes mainly originates from advective moisturemore » transport in the vertical direction. At most vertical levels over the tropics and in the lower atmosphere over the subtropics, the vertical eddy transport of mean moisture field dominates the contribution to precipitation extremes and its resolution dependency. Over the subtropics, the source of moisture, its associated energy, and the resolution dependency during extremes are dominated by eddy transport of eddies moisture at the mid- and upper-troposphere. With both MPAS and HOMME dynamical cores, the resolution dependency of the vertical advective moisture convergence is mainly explained by dynamical changes (related to vertical velocity or omega), although the vertical gradients of moisture act like averaging kernels to determine the sensitivity of the overall resolution dependency to the changes in omega at different vertical levels. The natural reduction of variability with coarser resolution, represented by areal data averaging (aggregation) effect, largely explains the resolution dependency in omega. The thermodynamic changes, which likely result from non-linear feedback in response to the large dynamical changes, are small compared to the overall changes in dynamics (omega). However, after excluding the data aggregation effect in omega, thermodynamic changes become relatively significant in offsetting the effect of dynamics leading to reduce differences between the simulated and aggregated results. Compared to MPAS, the simulated stronger vertical motion with HOMME also results in larger resolution dependency. Compared to the simulation at fine resolution, the vertical motion during extremes is insufficiently resolved/parameterized at the coarser resolution even after accounting for the natural reduction in variability with coarser resolution, and this is more distinct in the simulation with HOMME. To reduce uncertainties in simulated precipitation extremes, future development in cloud parameterizations must address their sensitivity to spatial resolution as well as dynamical cores.« less

Observations and estimates of wave-driven water level extremes at the Marshall Islands

NASA Astrophysics Data System (ADS)

Merrifield, M. A.; Becker, J. M.; Ford, M.; Yao, Y.

2014-10-01

Wave-driven extreme water levels are examined for coastlines protected by fringing reefs using field observations obtained in the Republic of the Marshall Islands. The 2% exceedence water level near the shoreline due to waves is estimated empirically for the study sites from breaking wave height at the outer reef and by combining separate contributions from setup, sea and swell, and infragravity waves, which are estimated based on breaking wave height and water level over the reef flat. Although each component exhibits a tidal dependence, they sum to yield a 2% exceedence level that does not. A hindcast based on the breaking wave height parameterization is used to assess factors leading to flooding at Roi-Namur caused by an energetic swell event during December 2008. Extreme water levels similar to December 2008 are projected to increase significantly with rising sea level as more wave and tide events combine to exceed inundation threshold levels.

Comparison of different statistical methods for estimation of extreme sea levels with wave set-up contribution

NASA Astrophysics Data System (ADS)

Kergadallan, Xavier; Bernardara, Pietro; Benoit, Michel; Andreewsky, Marc; Weiss, Jérôme

2013-04-01

Estimating the probability of occurrence of extreme sea levels is a central issue for the protection of the coast. Return periods of sea level with wave set-up contribution are estimated here in one site : Cherbourg in France in the English Channel. The methodology follows two steps : the first one is computation of joint probability of simultaneous wave height and still sea level, the second one is interpretation of that joint probabilities to assess a sea level for a given return period. Two different approaches were evaluated to compute joint probability of simultaneous wave height and still sea level : the first one is multivariate extreme values distributions of logistic type in which all components of the variables become large simultaneously, the second one is conditional approach for multivariate extreme values in which only one component of the variables have to be large. Two different methods were applied to estimate sea level with wave set-up contribution for a given return period : Monte-Carlo simulation in which estimation is more accurate but needs higher calculation time and classical ocean engineering design contours of type inverse-FORM in which the method is simpler and allows more complex estimation of wave setup part (wave propagation to the coast for example). We compare results from the two different approaches with the two different methods. To be able to use both Monte-Carlo simulation and design contours methods, wave setup is estimated with an simple empirical formula. We show advantages of the conditional approach compared to the multivariate extreme values approach when extreme sea-level occurs when either surge or wave height is large. We discuss the validity of the ocean engineering design contours method which is an alternative when computation of sea levels is too complex to use Monte-Carlo simulation method.

North Atlantic storm driving of extreme wave heights in the North Sea

NASA Astrophysics Data System (ADS)

Bell, R. J.; Gray, S. L.; Jones, O. P.

2017-04-01

The relationship between storms and extreme ocean waves in the North Sea is assessed using a long-period wave data set and storms identified in the Interim ECMWF Re-Analysis (ERA-Interim). An ensemble sensitivity analysis is used to provide information on the spatial and temporal forcing from mean sea-level pressure and surface wind associated with extreme ocean wave height responses. Extreme ocean waves in the central North Sea arise due to intense extratropical cyclone winds from either the cold conveyor belt (northerly-wind events) or the warm conveyor belt (southerly-wind events). The largest wave heights are associated with northerly-wind events which tend to have stronger wind speeds and occur as the cold conveyor belt wraps rearward round the cyclone to the cold side of the warm front. The northerly-wind events provide a larger fetch to the central North Sea to aid wave growth. Southerly-wind events are associated with the warm conveyor belts of intense extratropical cyclones that develop in the left upper tropospheric jet exit region. Ensemble sensitivity analysis can provide early warning of extreme wave events by demonstrating a relationship between wave height and high pressure to the west of the British Isles for northerly-wind events 48 h prior. Southerly-wind extreme events demonstrate sensitivity to low pressure to the west of the British Isles 36 h prior.

Extreme Ultraviolet Variability Experiment (EVE) on the Solar Dynamics Observatory (SDO): Overview of Science Objectives, Instrument Design, Data Products, and Model Developments

NASA Technical Reports Server (NTRS)

Woods, T. N.; Eparvier, F. G.; Hock, R.; Jones, A. R.; Woodraska, D.; Judge, D.; Didkovsky, L.; Lean, J.; Mariska, J.; Warren, H.;

Extremely Long-Lived Stigmas Allow Extended Cross-Pollination Opportunities in a High Andean Plant

PubMed Central

Torres-Díaz, Cristian; Gómez-González, Susana; Stotz, Gisela C.; Torres-Morales, Patricio; Paredes, Brayam; Pérez-Millaqueo, Matías; Gianoli, Ernesto

2011-01-01

High-elevation ecosystems are traditionally viewed as environments in which predominantly autogamous breeding systems should be selected because of the limited pollinator availability. Chaetanthera renifolia (Asteraceae) is an endemic monocarpic triennial herb restricted to a narrow altitudinal range within the high Andes of central Chile (3300–3500 m a.s.l.), just below the vegetation limit. This species displays one of the larger capitulum within the genus. Under the reproductive assurance hypothesis, and considering its short longevity (monocarpic triennial), an autogamous breeding system and low levels of pollen limitation would be predicted for C. renifolia. In contrast, considering its large floral size, a xenogamous breeding system, and significant levels of pollen limitation could be expected. In addition, the increased pollination probability hypothesis predicts prolonged stigma longevity for high alpine plants. We tested these alternative predictions by performing experimental crossings in the field to establish the breeding system and to measure the magnitude of pollen limitation in two populations of C. renifolia. In addition, we measured the stigma longevity in unpollinated and open pollinated capitula, and pollinator visitation rates in the field. We found low levels of self-compatibility and significant levels of pollen limitation in C. renifolia. Pollinator visitation rates were moderate (0.047–0.079 visits per capitulum per 30 min). Although pollinator visitation rate significantly differed between populations, they were not translated into differences in achene output. Finally, C. renifolia stigma longevity of unpollinated plants was extremely long and significantly higher than that of open pollinated plants (26.3±2.8 days vs. 10.1±2.2, respectively), which gives support to the increased pollination probability hypothesis for high-elevation flowering plants. Our results add to a growing number of studies that show that xenogamous breeding systems and mechanisms to increase pollination opportunities can be selected in high-elevation ecosystems. PMID:21573159

14 CFR 23.203 - Turning flight and accelerated turning stalls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... § 23.201(b), it must be possible to regain wings level flight by normal use of the flight controls, but... percent of maximum continuous power results in extreme nose-up attitudes, the test may be carried out with..., if the power-to-weight ratio at 75 percent of maximum continuous power results in nose-high attitudes...

Root and shoot transcriptome analysis of two ecotypes of Noccaea caerulescens uncovers the role of NcNramp1 in Cd hyperaccumulation

USDA-ARS?s Scientific Manuscript database

The Zn/Cd hyperaccumulator, Noccaea caerulescens, has been studied extensively for its ability to accumulate Zn and Cd in its leaves to extremely high levels. Previous studies have indicated that the Zn and Cd hyperaccumulation trait exhibited by this species involves different transport and toleran...

Perspectives on Leadership

DTIC Science & Technology

2008-01-01

LEADERSHIP -82- commitment ethic, stress management, and self esteem . The problematic indicators measured are aggression, deference, and change...Junior level followers usually have lower self - esteem , seek satisfaction outside of work, interrupt their careers, and receive more satisfaction from...justify an inflated view of their character, thereby exhibiting a self -righteous attitude and adds, an extremely “high self esteem creates a moral

Alterations in Upper Extremity Motor Function in Soldiers during Acute High Altitude Exposure,

DTIC Science & Technology

1988-03-01

sensitive or controversial items. a°. Encl ALLEN CYMERIAN, Ph.D. c, ARD . SGRD-UEZ ( ) - THRU Chief, Admin Svc Br FROM Commander DATE A p odk CMT 2 TO ak 2...Function orientation and familiarization with all the tests and procedures. Prior to actual sea-level collections , each subject underwent two UEMA

Noise impact issues on the Great Walks of New Zealand

Treesearch

Gordon R. Cessford

2000-01-01

This paper describes the features of recreational noise impacts and presents examples from popular New Zealand backcountry trails. Some noise effects were noticed at very high levels, and a varied range of tolerance for these was noted. Aircraft noise provided the most extreme impact example, while noise impacts from motorboats and social behaviour in huts were also...

Abnormally low hCG in a complete hydatidiform molar pregnancy: The hook effect.

PubMed

Nodler, James L; Kim, Kenneth H; Alvarez, Ronald D

2011-01-01

► The hook effect occurs with extremely high levels of hCG, saturating detection antibodies, leading to falsely low laboratory results. ► In the literature, descriptions of the hook effect are rare in cases of gestational trophoblastic diseases. ► If unrecognized, this can lead to delayed therapy or mismanagement of care.

Fungus cultivation by ambrosia beetles: Behavior and laboratory breeding success in three Xyleborine species

Treesearch

Peter Biedermann; Kier Klepzig; Taborsky Michael

2009-01-01

Fungus cultivation by ambrosia beetles is one of the four independently evolved cases of agriculture known in animals. Such cultivation is most advanced in the highly social subtribe Xyleborina (Scolytinae), which is characterized by haplodiploidy and extreme levels of inbreeding. Despite their ubiquity in forests worldwide, the behavior of these beetles remains poorly...

Interaction effects of temperature and ozone on lung function and markers of systemic inflammation, coagulation, and fibrinolysis: A crossover study of healthy young volunteers

EPA Science Inventory

BACKGROUND: Trends in climate suggest that extreme weather events such as heat waves will become more common. High levels of the gaseous pollutant ozone are associated with elevated temperatures. Ozone has been associated with respiratory diseases as well as cardiovascular morbid...

Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures

PubMed Central

Hawkes, W. G.; Glowacki, J.; Yu-Yahiro, J.; Hurwitz, S.; Magaziner, J.

2008-01-01

Summary We determined the prevalence of vitamin D deficiency and lower extremity function in women with hip fractures. Women with extremely low vitamin D levels had reduced lower extremity muscle function and increased falls 1 year later. Ensuring vitamin D sufficiency after a hip fracture may improve function and reduce falls. Introduction Hip fractures are the most devastating of fractures, commonly leading to loss of independent ambulation and living. In this retrospective analysis we determined the prevalence of vitamin D deficiency in women with hip fractures and the association between 25-hydroxyvitamin D [25(OH)D] levels and functional impairment one year later. Methods One hundred ten community-dwelling women with hip fractures were recruited from Boston, MA (n= 30) and Baltimore, MD (n=80) before 1998 and 25(OH)D levels were measured by radioimmunoassay. In a subset of women from Baltimore, a performance measure of the lower extremities using the lower extremity gain scale (LEGS) was measured at 2, 6, and 12 months. Falls, grip strength, chair rise time, walking speed, and balance were also determined. Results Vitamin D insufficiency defined as a 25(OH)D ≤32 ng/mL was present in 96% of the women with hip fractures and 38% had extremely low levels ≤9 ng/mL. At 1 year post-fracture, compared to women with a 25(OH) D >9 ng/mL, those with 25(OH)D ≤9 ng/mL had poorer LEGS performance (p<0.0001) and higher fall rates, without group differences in grip strength or balance. Conclusion Vitamin D sufficiency may have important effects on lower extremity function following hip fractures, without excessive healthcare costs. PMID:18373057

Rising sea levels will reduce extreme temperature variations in tide-dominated reef habitats

PubMed Central

Lowe, Ryan Joseph; Pivan, Xavier; Falter, James; Symonds, Graham; Gruber, Renee

2016-01-01

Temperatures within shallow reefs often differ substantially from those in the surrounding ocean; therefore, predicting future patterns of thermal stresses and bleaching at the scale of reefs depends on accurately predicting reef heat budgets. We present a new framework for quantifying how tidal and solar heating cycles interact with reef morphology to control diurnal temperature extremes within shallow, tidally forced reefs. Using data from northwestern Australia, we construct a heat budget model to investigate how frequency differences between the dominant lunar semidiurnal tide and diurnal solar cycle drive ~15-day modulations in diurnal temperature extremes. The model is extended to show how reefs with tidal amplitudes comparable to their depth, relative to mean sea level, tend to experience the largest temperature extremes globally. As a consequence, we reveal how even a modest sea level rise can substantially reduce temperature extremes within tide-dominated reefs, thereby partially offsetting the local effects of future ocean warming. PMID:27540589

78 FR 62341 - Continuation of the National Emergency With Respect to Significant Narcotics Traffickers Centered...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-18

... traffickers centered in Colombia and the extreme level of violence, corruption, and harm such actions cause in... an extreme level of violence, corruption, and harm in the United States and abroad. For these reasons...

Warmest extreme year in U.S. history alters thermal requirements for tree phenology.

PubMed

Carter, Jacob M; Orive, Maria E; Gerhart, Laci M; Stern, Jennifer H; Marchin, Renée M; Nagel, Joane; Ward, Joy K

2017-04-01

The frequency of extreme warm years is increasing across the majority of the planet. Shifts in plant phenology in response to extreme years can influence plant survival, productivity, and synchrony with pollinators/herbivores. Despite extensive work on plant phenological responses to climate change, little is known about responses to extreme warm years, particularly at the intraspecific level. Here we investigate 43 populations of white ash trees (Fraxinus americana) from throughout the species range that were all grown in a common garden. We compared the timing of leaf emergence during the warmest year in U.S. history (2012) with relatively non-extreme years. We show that (a) leaf emergence among white ash populations was accelerated by 21 days on average during the extreme warm year of 2012 relative to non-extreme years; (b) rank order for the timing of leaf emergence was maintained among populations across extreme and non-extreme years, with southern populations emerging earlier than northern populations; (c) greater amounts of warming units accumulated prior to leaf emergence during the extreme warm year relative to non-extreme years, and this constrained the potential for even earlier leaf emergence by an average of 9 days among populations; and (d) the extreme warm year reduced the reliability of a relevant phenological model for white ash by producing a consistent bias toward earlier predicted leaf emergence relative to observations. These results demonstrate a critical need to better understand how extreme warm years will impact tree phenology, particularly at the intraspecific level.

Cancer immunotherapy: Breakthrough or "deja vu, all over again"?

PubMed

Sell, Stewart

2017-06-01

From the application of Coley's toxin in the early 1900s to the present clinical trials using immune checkpoint regulatory inhibitors, the history of cancer immunotherapy has consisted of extremely high levels of enthusiasm after anecdotal case reports of enormous success, followed by decreasing levels of enthusiasm as the results of controlled clinical trials are available. In this review, this pattern will be documented for the various immunotherapeutic approaches over the years. The sole exception being vaccination against cancer causing viruses, which have already prevented thousands of cancers. We can only hope that the present high level of enthusiasm for the use of immune stimulation by removal of blocks to cancer immunity will be more productive than the incremental improvements using previous immunotherapies.

Classification and evaluation of the documentary-recorded storm events in the Annals of the Choson Dynasty (1392-1910), Korea

NASA Astrophysics Data System (ADS)

Yoo, Chulsang; Park, Minkyu; Kim, Hyeon Jun; Choi, Juhee; Sin, Jiye; Jun, Changhyun

2015-01-01

In this study, the analysis of documentary records on the storm events in the Annals of the Choson Dynasty, covering the entire period of 519 years from 1392 to 1910, was carried out. By applying various key words related to storm events, a total of 556 documentary records could be identified. The main objective of this study was to develop rules of classification for the documentary records on the storm events in the Annals of the Choson Dynasty. The results were also compared with the rainfall data of the traditional Korean rain gauge, named Chukwooki, which are available from 1777 to 1910 (about 130 years). The analysis is organized as follows. First, the frequency of the documents, their length, comments about the size of the inundated area, the number of casualties, the number of property losses, and the size of the countermeasures, etc. were considered to determine the magnitude of the events. To this end, rules of classification of the storm events are developed. Cases in which the word 'disaster' was used along with detailed information about the casualties and property damages, were classified as high-level storm events. The high-level storm events were additionally sub-categorized into catastrophic, extreme, and severe events. Second, by applying the developed rules of classification, a total of 326 events were identified as high-level storm events during the 519 years of the Choson Dynasty. Among these high-level storm events, only 19 events were then classified as the catastrophic ones, 106 events as the extreme ones, and 201 events as the severe ones. The mean return period of these storm events was found to be about 30 years for the catastrophic events, 5 years for the extreme events, and 2-3 years for the severe events. Third, the classification results were verified considering the records of the traditional Korean rain gauge; it was found that the catastrophic events are strongly distinguished from other events with a mean total rainfall and a storm duration equal to 439.8 mm and 49.3 h, respectively. The return period of these catastrophic events was also estimated to be in the range 100-500 years.

Measurement Properties of the Lower Extremity Functional Scale: A Systematic Review.

PubMed

Mehta, Saurabh P; Fulton, Allison; Quach, Cedric; Thistle, Megan; Toledo, Cesar; Evans, Neil A

2016-03-01

Systematic review of measurement properties. Many primary studies have examined the measurement properties, such as reliability, validity, and sensitivity to change, of the Lower Extremity Functional Scale (LEFS) in different clinical populations. A systematic review summarizing these properties for the LEFS may provide an important resource. To locate and synthesize evidence on the measurement properties of the LEFS and to discuss the clinical implications of the evidence. A literature search was conducted in 4 databases (PubMed, MEDLINE, Embase, and CINAHL), using predefined search terms. Two reviewers performed a critical appraisal of the included studies using a standardized assessment form. A total of 27 studies were included in the review, of which 18 achieved a very good to excellent methodological quality level. The LEFS scores demonstrated excellent test-retest reliability (intraclass correlation coefficients ranging between 0.85 and 0.99) and demonstrated the expected relationships with measures assessing similar constructs (Pearson correlation coefficient values of greater than 0.7). The responsiveness of the LEFS scores was excellent, as suggested by consistently high effect sizes (greater than 0.8) in patients with different lower extremity conditions. Minimal detectable change at the 90% confidence level (MDC90) for the LEFS scores varied between 8.1 and 15.3 across different reassessment intervals in a wide range of patient populations. The pooled estimate of the MDC90 was 6 points and the minimal clinically important difference was 9 points in patients with lower extremity musculoskeletal conditions, which are indicative of true change and clinically meaningful change, respectively. The results of this review support the reliability, validity, and responsiveness of the LEFS scores for assessing functional impairment in a wide array of patient groups with lower extremity musculoskeletal conditions.

Cyanopyridine Based Bipolar Host Materials for Green Electrophosphorescence with Extremely Low Turn-On Voltages and High Power Efficiencies.

PubMed

Li, Wei; Li, Jiuyan; Liu, Di; Li, Deli; Wang, Fang

2016-08-24

Low driving voltage and high power efficiency are basic requirements when practical applications of organic light emitting diodes (OLEDs) in displays and lighting are considered. Two novel host materials m-PyCNmCP and 3-PyCNmCP incorporating cyanopyridine moiety as electron-transporting unit are developed for use in fac-tris(2-phenylpyridine)iridium(III) (Ir(ppy)3) based green phosphorescent OLEDs (PhOLEDs). Extremely low turn-on voltages of 2.01 and 2.27 V are realized, which are even lower than the theoretical limit of the emitted photon energy (hv)/electron charge (e) (2.37 V) of Ir(ppy)3. High power efficiency of 101.4 lm/W (corresponding to a maximum external quantum efficiency of 18.4%) and 119.3 lm/W (24.7%) are achieved for m-PyCNmCP and 3-PyCNmCP based green PhOLEDs. The excellent EL performance benefits from the ideal parameters of host materials by combining cyano and pyridine to enhance the n-type feature. The energetic favorable alignment of HOMO/LUMO levels of hosts with adjacent layers and the dopant for easy charge injections and direct charge trapping by dopant, their bipolar feature to balance charge transportations, sufficiently high triplet energy and small singlet/triplet energy difference (0.38 and 0.43 eV) combine to be responsible for the extremely low driving voltages and high power efficiencies of the green PhOLEDs.

Connecting large-scale atmospheric circulation, river flow and groundwater levels in a chalk catchment in southern England

NASA Astrophysics Data System (ADS)

Lavers, David A.; Hannah, David M.; Bradley, Chris

2015-04-01

Groundwater is an important water resource and globally it represents the largest distributed store of freshwater. In southern England, groundwater is a major source for public water supply, and many aquifers have recently experienced both extreme low and high groundwater levels. In this paper, we use observations of precipitation, river discharge and groundwater levels (1964-2010) and an atmospheric reanalysis to explore the large-scale climate patterns preceding the nine highest and lowest March river discharge and groundwater levels in the chalk catchment of the River Lambourn (Berkshire Downs, southern England). Peak monthly precipitation is shown to occur from October to January, while the highest river discharge and groundwater levels are found from February to April. For high discharge/groundwater levels, composite anomaly patterns of the mean sea level pressure show a stronger than average pressure gradient across the North Atlantic Ocean, with enhanced water vapour transport across southern England. For the lowest discharge/groundwater levels, a blocking high pressure system is found across the British Isles deflecting storms and precipitation to the north. Significantly, the intra-composite variability suggests that different sequences of atmospheric states may lead to high and low discharge/groundwater events.

Frequency and Character of Extreme Aerosol Events in the Southwestern United States: A Case Study Analysis in Arizona

PubMed Central

Lopez, David H.; Rabbani, Michael R.; Crosbie, Ewan; Raman, Aishwarya; Arellano, Avelino F.; Sorooshian, Armin

2016-01-01

This study uses more than a decade’s worth of data across Arizona to characterize the spatiotemporal distribution, frequency, and source of extreme aerosol events, defined as when the concentration of a species on a particular day exceeds that of the average plus two standard deviations for that given month. Depending on which of eight sites studied, between 5% and 7% of the total days exhibited an extreme aerosol event due to either extreme levels of PM10, PM2.5, and/or fine soil. Grand Canyon exhibited the most extreme event days (120, i.e., 7% of its total days). Fine soil is the pollutant type that most frequently impacted multiple sites at once at an extreme level. PM10, PM2.5, fine soil, non-Asian dust, and Elemental Carbon extreme events occurred most frequently in August. Nearly all Asian dust extreme events occurred between March and June. Extreme Elemental Carbon events have decreased as a function of time with statistical significance, while other pollutant categories did not show any significant change. Extreme events were most frequent for the various pollutant categories on either Wednesday or Thursday, but there was no statistically significant difference in the number of events on any particular day or on weekends versus weekdays. PMID:27088005

Vulnerability, safety and response of nuclear power plants to the hydroclimatic hazards

NASA Astrophysics Data System (ADS)

János Katona, Tamás; Vilimi, András

2016-04-01

The Great Tohoku Earthquake and Tsunami, and the severe accident at Fukushima Dai-ichi nuclear power plant 2011 alerted the nuclear industry to danger of extreme rare natural hazards. The subsequent "stress tests" performed by the nuclear industry in Europe and all over the world identifies the nuclear power plant (NPP) vulnerabilities and define the measures for increasing the plant safety. According to the international practice of nuclear safety regulations, the cumulative core damage frequency for NPPs has to be 10-5/a, and the cumulative frequency of early large release has to be 10-6/a. In case of operating plants these annual probabilities can be little higher, but the licensees are obliged to implement all reasonable practicable measures for increasing the plant safety. For achieving the required level of safety, design basis of NPPs for natural hazards has to be defined at the 10-4/a ⎯10-5/a levels of annual exceedance probability. Tornado hazard is some kind of exception, e.g., the design basis annual probability for tornado in the US is equal to 10-7/a. Design of the NPPs shall provide for an adequate margin to protect items ultimately necessary to prevent large or early radioactive releases in the event of levels of natural hazards exceeding those to be considered for design. The plant safety has to be reviewed for accounting the changes of the environmental conditions and natural hazards in case of necessity, but as minimum every ten years in the frame of periodic safety reviews. Long-term forecast of environmental conditions and hazards has to be accounted for in the design basis of the new plants. Changes in hydroclimatic variables, e.g., storms, tornadoes, river floods, flash floods, extreme temperatures, droughts affect the operability and efficiency as well as the safety the NPPs. Low flow rates and high water temperature in the rivers may force to operate at reduced power level or shutdown the plant (Cernavoda NPP, Romania, August 2009). The practice demonstrated that the NPPs could safely withstand the meteorological extremes (Katrina hurricane, 2005). However the floods at some sites cause significant safety issues. Design of NPPs and their response to extreme hydroclimatic events depends on the features of particular hazards, e.g., predictability, possibility and time available for the protective actions, potential for causing cliff-edge effects and the possible combinations of events. The uncertainty of the prediction of extreme values for the design and safety assessment is a fundamental issue. In the paper the consequences of hydroclimatic extremes are analysed for nuclear power plants. The possibility of operational response to extremes is presented. The safety margins are assessed with respect to the effects caused by hydroclimatic extremes. The direct actions (e.g. wind) and the indirect consequences (e.g. changing of ground water level) are also considered. Methods for accounting the uncertainties of the characterisation of low probability hazards are also considered. The preparedness to severe hydroclimatic conditions / events and actions for mitigation and management are presented and discussed. The considerations in the paper are illustrated by the case of the Paks Nuclear Power Plant, Hungary.

Urban renewal based wind environment at pedestrian level in high-density and high-rise urban areas in Sai Ying Pun, Hong Kong

NASA Astrophysics Data System (ADS)

Yao, J. W.; Zheng, J. Y.; Zhao, Y.; Shao, Y. H.; Yuan, F.

2017-11-01

In high-density and high-rise urban areas, pedestrian level winds contribute to improve comfort, safety and diffusion of heat in urban areas. Outdoor wind study is extremely vital and a prerequisite in high-density cities considering that the immediate pedestrian level wind environment is fundamentally impacted by the presence of a series of high-rise buildings. In this paper, the research site of Sai Ying Pun in Hong Kong will be analysed in terms of geography, climate and urban morphology, while the surrounding natural ventilation has also been simulated by the wind tunnel experiment Computational Fluid Dynamics (CFD). It has found that, the existing problems in this district are the contradiction between planning control and commercial interests, which means some areas around tall buildings are not benefit to the residents because of the unhealthy wind environment. Therefore, some recommendation of urban renewal strategy has been provided.

Technology improves upper extremity rehabilitation.

PubMed

Kowalczewski, Jan; Prochazka, Arthur

2011-01-01

Stroke survivors with hemiparesis and spinal cord injury (SCI) survivors with tetraplegia find it difficult or impossible to perform many activities of daily life. There is growing evidence that intensive exercise therapy, especially when supplemented with functional electrical stimulation (FES), can improve upper extremity function, but delivering the treatment can be costly, particularly after recipients leave rehabilitation facilities. Recently, there has been a growing level of interest among researchers and healthcare policymakers to deliver upper extremity treatments to people in their homes using in-home teletherapy (IHT). The few studies that have been carried out so far have encountered a variety of logistical and technical problems, not least the difficulty of conducting properly controlled and blinded protocols that satisfy the requirements of high-level evidence-based research. In most cases, the equipment and communications technology were not designed for individuals with upper extremity disability. It is clear that exercise therapy combined with interventions such as FES, supervised over the Internet, will soon be adopted worldwide in one form or another. Therefore it is timely that researchers, clinicians, and healthcare planners interested in assessing IHT be aware of the pros and cons of the new technology and the factors involved in designing appropriate studies of it. It is crucial to understand the technical barriers, the role of telesupervisors, the motor improvements that participants can reasonably expect and the process of optimizing IHT-exercise therapy protocols to maximize the benefits of the emerging technology. Copyright © 2011 Elsevier B.V. All rights reserved.

Interpreting Mammalian Evolution using Fugu Genome Comparisons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stubbs, L; Ovcharenko, I; Loots, G G

2004-04-02

Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.

The paradox of extreme high-altitude migration in bar-headed geese Anser indicus

PubMed Central

Hawkes, L. A.; Balachandran, S.; Batbayar, N.; Butler, P. J.; Chua, B.; Douglas, D. C.; Frappell, P. B.; Hou, Y.; Milsom, W. K.; Newman, S. H.; Prosser, D. J.; Sathiyaselvam, P.; Scott, G. R.; Takekawa, J. Y.; Natsagdorj, T.; Wikelski, M.; Witt, M. J.; Yan, B.; Bishop, C. M.

2013-01-01

Bar-headed geese are renowned for migratory flights at extremely high altitudes over the world's tallest mountains, the Himalayas, where partial pressure of oxygen is dramatically reduced while flight costs, in terms of rate of oxygen consumption, are greatly increased. Such a mismatch is paradoxical, and it is not clear why geese might fly higher than is absolutely necessary. In addition, direct empirical measurements of high-altitude flight are lacking. We test whether migrating bar-headed geese actually minimize flight altitude and make use of favourable winds to reduce flight costs. By tracking 91 geese, we show that these birds typically travel through the valleys of the Himalayas and not over the summits. We report maximum flight altitudes of 7290 m and 6540 m for southbound and northbound geese, respectively, but with 95 per cent of locations received from less than 5489 m. Geese travelled along a route that was 112 km longer than the great circle (shortest distance) route, with transit ground speeds suggesting that they rarely profited from tailwinds. Bar-headed geese from these eastern populations generally travel only as high as the terrain beneath them dictates and rarely in profitable winds. Nevertheless, their migration represents an enormous challenge in conditions where humans and other mammals are only able to operate at levels well below their sea-level maxima. PMID:23118436

The paradox of extreme high-altitude migration in bar-headed geese Anser indicus

USGS Publications Warehouse

Hawkes, L.A.; Balachandran, S.; Batbayar, N.; Butler, P.J.; Chua, B.; Douglas, David C.; Frappell, P.B.; Hou, Y.; Milsom, W.K.; Newman, S.H.; Prosser, D.J.; Sathiyaselvam, P.; Scott, G.R.; Takekawa, John Y.; Natsagdorj, T.; Wikelski, M.; Witt, M.J.; Yan, B.; Bishop, C.M.

2012-01-01

Bar-headed geese are renowned for migratory flights at extremely high altitudes over the world's tallest mountains, the Himalayas, where partial pressure of oxygen is dramatically reduced while flight costs, in terms of rate of oxygen consumption, are greatly increased. Such a mismatch is paradoxical, and it is not clear why geese might fly higher than is absolutely necessary. In addition, direct empirical measurements of high-altitude flight are lacking. We test whether migrating bar-headed geese actually minimize flight altitude and make use of favourable winds to reduce flight costs. By tracking 91 geese, we show that these birds typically travel through the valleys of the Himalayas and not over the summits. We report maximum flight altitudes of 7290 m and 6540 m for southbound and northbound geese, respectively, but with 95 per cent of locations received from less than 5489 m. Geese travelled along a route that was 112 km longer than the great circle (shortest distance) route, with transit ground speeds suggesting that they rarely profited from tailwinds. Bar-headed geese from these eastern populations generally travel only as high as the terrain beneath them dictates and rarely in profitable winds. Nevertheless, their migration represents an enormous challenge in conditions where humans and other mammals are only able to operate at levels well below their sea-level maxima.

Extremely fine structured cathode for solid oxide fuel cells using Sr-doped LaMnO3 and Y2O3-stabilized ZrO2 nano-composite powder synthesized by spray pyrolysis

NASA Astrophysics Data System (ADS)

Shimada, Hiroyuki; Yamaguchi, Toshiaki; Sumi, Hirofumi; Nomura, Katsuhiro; Yamaguchi, Yuki; Fujishiro, Yoshinobu

2017-02-01

A solid oxide fuel cell (SOFC) for high power density operation was developed with a microstructure-controlled cathode using a nano-composite powder of Sr-doped LaMnO3 (LSM) and Y2O3-stabilized ZrO2 (YSZ) synthesized by spray pyrolysis. The individual LSM-YSZ nano-composite particles, formed by crystalline and amorphous nano-size LSM and YSZ particles, showed spherical morphology with uniform particle size. The use of this powder for cathode material led to an extremely fine microstructure, in which all the LSM and YSZ grains (approximately 100-200 nm) were highly dispersed and formed their own network structures. This microstructure was due to the two phase electrode structure control using the powder, namely, nano-order level in each particle and micro-order level between particles. An anode-supported SOFC with the LSM-YSZ cathode using humidified H2 as fuel and ambient air as oxidant exhibited high power densities, such as 1.29 W cm-2 under a voltage of 0.75 V and a maximum power density of 2.65 W cm-2 at 800 °C. Also, the SOFC could be stably operated for 250 h with no degradation, even at a high temperature of 800 °C.

How Historical Information Can Improve Extreme Value Analysis of Coastal Water Levels

NASA Astrophysics Data System (ADS)

Le Cozannet, G.; Bulteau, T.; Idier, D.; Lambert, J.; Garcin, M.

2016-12-01

The knowledge of extreme coastal water levels is useful for coastal flooding studies or the design of coastal defences. While deriving such extremes with standard analyses using tide gauge measurements, one often needs to deal with limited effective duration of observation which can result in large statistical uncertainties. This is even truer when one faces outliers, those particularly extreme values distant from the others. In a recent work (Bulteau et al., 2015), we investigated how historical information of past events reported in archives can reduce statistical uncertainties and relativize such outlying observations. We adapted a Bayesian Markov Chain Monte Carlo method, initially developed in the hydrology field (Reis and Stedinger, 2005), to the specific case of coastal water levels. We applied this method to the site of La Rochelle (France), where the storm Xynthia in 2010 generated a water level considered so far as an outlier. Based on 30 years of tide gauge measurements and 8 historical events since 1890, the results showed a significant decrease in statistical uncertainties on return levels when historical information is used. Also, Xynthia's water level no longer appeared as an outlier and we could have reasonably predicted the annual exceedance probability of that level beforehand (predictive probability for 2010 based on data until the end of 2009 of the same order of magnitude as the standard estimative probability using data until the end of 2010). Such results illustrate the usefulness of historical information in extreme value analyses of coastal water levels, as well as the relevance of the proposed method to integrate heterogeneous data in such analyses.

Childhood behavioral inhibition is associated with impaired mentalizing in adolescence

PubMed Central

Pérez-Domingo, Ariadna; Vives, Jaume; Sharp, Carla; Barrantes-Vidal, Neus

2018-01-01

Recent advances suggest that impairment in social cognition (SC) may play a role in the development of social anxiety (SA). However, very few studies have analyzed whether SA fosters poorer social-cognitive development as it leads to social avoidance. This study aimed to analyze whether retrospectively assessed behavioral inhibition (BI) (i.e., an early form of SA) in childhood is associated with a deficit in social cognition operationalized as impairment of mentalizing (MZ) in adolescence. A sample of 256 adolescents (range: 12–18 years; mean age: 14.7 years; SD = 1.7) from general population were assessed for MZ capacities and retrospective BI through self-report and interview measures. Results comparing three groups of adolescents with different levels of childhood BI (low, moderate or high) and controlling for concurrent SA and depression reveal that the higher the level of BI, the lower the level of MZ. These results were consistent for almost all mentalization measures, including when both extreme (i.e., high vs. low BI) and non-extreme (i.e., high vs. moderate BI) were compared in both self-report and interview measures and in both dimensions of MZ (i.e., MZ referred to others’ and to own mental states). These findings support that childhood forms of SA are associated to deficit in SC in adolescence. A possible bi-directional relationship between SA and SC, and the role that it may play in the pathway to clinical SA are discussed. PMID:29596505

Childhood behavioral inhibition is associated with impaired mentalizing in adolescence.

PubMed

Ballespí, Sergi; Pérez-Domingo, Ariadna; Vives, Jaume; Sharp, Carla; Barrantes-Vidal, Neus

2018-01-01

Recent advances suggest that impairment in social cognition (SC) may play a role in the development of social anxiety (SA). However, very few studies have analyzed whether SA fosters poorer social-cognitive development as it leads to social avoidance. This study aimed to analyze whether retrospectively assessed behavioral inhibition (BI) (i.e., an early form of SA) in childhood is associated with a deficit in social cognition operationalized as impairment of mentalizing (MZ) in adolescence. A sample of 256 adolescents (range: 12-18 years; mean age: 14.7 years; SD = 1.7) from general population were assessed for MZ capacities and retrospective BI through self-report and interview measures. Results comparing three groups of adolescents with different levels of childhood BI (low, moderate or high) and controlling for concurrent SA and depression reveal that the higher the level of BI, the lower the level of MZ. These results were consistent for almost all mentalization measures, including when both extreme (i.e., high vs. low BI) and non-extreme (i.e., high vs. moderate BI) were compared in both self-report and interview measures and in both dimensions of MZ (i.e., MZ referred to others' and to own mental states). These findings support that childhood forms of SA are associated to deficit in SC in adolescence. A possible bi-directional relationship between SA and SC, and the role that it may play in the pathway to clinical SA are discussed.

The Essential Role of the Deinococcus radiodurans ssb Gene in Cell Survival and Radiation Tolerance

PubMed Central

Lockhart, J. Scott; DeVeaux, Linda C.

2013-01-01

Recent evidence has implicated single-stranded DNA-binding protein (SSB) expression level as an important factor in microbial radiation resistance. The genome of the extremely radiation resistant bacterium Deinococcus radiodurans contains genes for two SSB homologs: the homodimeric, canonical Ssb, encoded by the gene ssb, and a novel pentameric protein encoded by the gene ddrB. ddrB is highly induced upon exposure to radiation, and deletions result in decreased radiation-resistance, suggesting an integral role of the protein in the extreme resistance exhibited by this organism. Although expression of ssb is also induced after irradiation, Ssb is thought to be involved primarily in replication. In this study, we demonstrate that Ssb in D. radiodurans is essential for cell survival. The lethality of an ssb deletion cannot be complemented by providing ddrB in trans. In addition, the radiation-sensitive phenotype conferred by a ddrB deletion is not alleviated by providing ssb in trans. By altering expression of the ssb gene, we also show that lower levels of transcription are required for optimal growth than are necessary for high radiation resistance. When expression is reduced to that of E. coli, ionizing radiation resistance is similarly reduced. UV resistance is also decreased under low ssb transcript levels where growth is unimpaired. These results indicate that the expression of ssb is a key component of both normal cellular metabolism as well as pathways responsible for the high radiation tolerance of D. radiodurans. PMID:23951213

Modeling Compound Flood Hazards in Coastal Embayments

NASA Astrophysics Data System (ADS)

Moftakhari, H.; Schubert, J. E.; AghaKouchak, A.; Luke, A.; Matthew, R.; Sanders, B. F.

2017-12-01

Coastal cities around the world are built on lowland topography adjacent to coastal embayments and river estuaries, where multiple factors threaten increasing flood hazards (e.g. sea level rise and river flooding). Quantitative risk assessment is required for administration of flood insurance programs and the design of cost-effective flood risk reduction measures. This demands a characterization of extreme water levels such as 100 and 500 year return period events. Furthermore, hydrodynamic flood models are routinely used to characterize localized flood level intensities (i.e., local depth and velocity) based on boundary forcing sampled from extreme value distributions. For example, extreme flood discharges in the U.S. are estimated from measured flood peaks using the Log-Pearson Type III distribution. However, configuring hydrodynamic models for coastal embayments is challenging because of compound extreme flood events: events caused by a combination of extreme sea levels, extreme river discharges, and possibly other factors such as extreme waves and precipitation causing pluvial flooding in urban developments. Here, we present an approach for flood risk assessment that coordinates multivariate extreme analysis with hydrodynamic modeling of coastal embayments. First, we evaluate the significance of correlation structure between terrestrial freshwater inflow and oceanic variables; second, this correlation structure is described using copula functions in unit joint probability domain; and third, we choose a series of compound design scenarios for hydrodynamic modeling based on their occurrence likelihood. The design scenarios include the most likely compound event (with the highest joint probability density), preferred marginal scenario and reproduced time series of ensembles based on Monte Carlo sampling of bivariate hazard domain. The comparison between resulting extreme water dynamics under the compound hazard scenarios explained above provides an insight to the strengths/weaknesses of each approach and helps modelers choose the appropriate scenario that best fit to the needs of their project. The proposed risk assessment approach can help flood hazard modeling practitioners achieve a more reliable estimate of risk, by cautiously reducing the dimensionality of the hazard analysis.

A Rasch-validated version of the upper extremity functional index for interval-level measurement of upper extremity function.

PubMed

Hamilton, Clayon B; Chesworth, Bert M

2013-11-01

The original 20-item Upper Extremity Functional Index (UEFI) has not undergone Rasch validation. The purpose of this study was to determine whether Rasch analysis supports the UEFI as a measure of a single construct (ie, upper extremity function) and whether a Rasch-validated UEFI has adequate reproducibility for individual-level patient evaluation. This was a secondary analysis of data from a repeated-measures study designed to evaluate the measurement properties of the UEFI over a 3-week period. Patients (n=239) with musculoskeletal upper extremity disorders were recruited from 17 physical therapy clinics across 4 Canadian provinces. Rasch analysis of the UEFI measurement properties was performed. If the UEFI did not fit the Rasch model, misfitting patients were deleted, items with poor response structure were corrected, and misfitting items and redundant items were deleted. The impact of differential item functioning on the ability estimate of patients was investigated. A 15-item modified UEFI was derived to achieve fit to the Rasch model where the total score was supported as a measure of upper extremity function only. The resultant UEFI-15 interval-level scale (0-100, worst to best state) demonstrated excellent internal consistency (person separation index=0.94) and test-retest reliability (intraclass correlation coefficient [2,1]=.95). The minimal detectable change at the 90% confidence interval was 8.1. Patients who were ambidextrous or bilaterally affected were excluded to allow for the analysis of differential item functioning due to limb involvement and arm dominance. Rasch analysis did not support the validity of the 20-item UEFI. However, the UEFI-15 was a valid and reliable interval-level measure of a single dimension: upper extremity function. Rasch analysis supports using the UEFI-15 in physical therapist practice to quantify upper extremity function in patients with musculoskeletal disorders of the upper extremity.

A Rasch-Validated Version of the Upper Extremity Functional Index for Interval-Level Measurement of Upper Extremity Function

PubMed Central

Chesworth, Bert M.

2013-01-01

Background The original 20-item Upper Extremity Functional Index (UEFI) has not undergone Rasch validation. Objective The purpose of this study was to determine whether Rasch analysis supports the UEFI as a measure of a single construct (ie, upper extremity function) and whether a Rasch-validated UEFI has adequate reproducibility for individual-level patient evaluation. Design This was a secondary analysis of data from a repeated-measures study designed to evaluate the measurement properties of the UEFI over a 3-week period. Methods Patients (n=239) with musculoskeletal upper extremity disorders were recruited from 17 physical therapy clinics across 4 Canadian provinces. Rasch analysis of the UEFI measurement properties was performed. If the UEFI did not fit the Rasch model, misfitting patients were deleted, items with poor response structure were corrected, and misfitting items and redundant items were deleted. The impact of differential item functioning on the ability estimate of patients was investigated. Results A 15-item modified UEFI was derived to achieve fit to the Rasch model where the total score was supported as a measure of upper extremity function only. The resultant UEFI-15 interval-level scale (0–100, worst to best state) demonstrated excellent internal consistency (person separation index=0.94) and test-retest reliability (intraclass correlation coefficient [2,1]=.95). The minimal detectable change at the 90% confidence interval was 8.1. Limitations Patients who were ambidextrous or bilaterally affected were excluded to allow for the analysis of differential item functioning due to limb involvement and arm dominance. Conclusion Rasch analysis did not support the validity of the 20-item UEFI. However, the UEFI-15 was a valid and reliable interval-level measure of a single dimension: upper extremity function. Rasch analysis supports using the UEFI-15 in physical therapist practice to quantify upper extremity function in patients with musculoskeletal disorders of the upper extremity. PMID:23813086

Ultrafast Extreme Ultraviolet Spectroscopy of Methylammonium Lead Iodide Perovskite for Carrier Specific Photophysics

NASA Astrophysics Data System (ADS)

Verkamp, Max A.; Lin, Ming-Fu; Ryland, Elizabeth S.; Benke, Kristin; Vura-Weis, Josh

2017-06-01

Methyl ammonium lead iodide (perovskite) is a leading candidate for next-generation solar cell devices. However, the fundamental photophysics responsible for its strong photovoltaic qualities are not fully understood. Ultrafast extreme ultraviolet (XUV) spectroscopy was used to investigate relaxation dynamics in perovskite with carrier specific signals arising from transitions from the common inner-shell level (I 4d) to the valence and conduction bands. Ultrashort (30 fs) pulses of XUV radiation in a broad spectrum (40-70 eV) were obtained using high-harmonic generation in a tabletop instrument. Transient absorption measurements with visible pump and XUV probe directly observed the dynamics of charge carriers after above-band and band-edge excitation.

Prefrontal/accumbal catecholamine system processes high motivational salience

PubMed Central

Puglisi-Allegra, Stefano; Ventura, Rossella

2012-01-01

Motivational salience regulates the strength of goal seeking, the amount of risk taken, and the energy invested from mild to extreme. Highly motivational experiences promote highly persistent memories. Although this phenomenon is adaptive in normal conditions, experiences with extremely high levels of motivational salience can promote development of memories that can be re-experienced intrusively for long time resulting in maladaptive outcomes. Neural mechanisms mediating motivational salience attribution are, therefore, very important for individual and species survival and for well-being. However, these neural mechanisms could be implicated in attribution of abnormal motivational salience to different stimuli leading to maladaptive compulsive seeking or avoidance. We have offered the first evidence that prefrontal cortical norepinephrine (NE) transmission is a necessary condition for motivational salience attribution to highly salient stimuli, through modulation of dopamine (DA) in the nucleus accumbens (NAc), a brain area involved in all motivated behaviors. Moreover, we have shown that prefrontal-accumbal catecholamine (CA) system determines approach or avoidance responses to both reward- and aversion-related stimuli only when the salience of the unconditioned stimulus (UCS) is high enough to induce sustained CA activation, thus affirming that this system processes motivational salience attribution selectively to highly salient events. PMID:22754514

Significant mobility enhancement in extremely thin highly doped ZnO films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Look, David C., E-mail: david.look@wright.edu; Wyle Laboratories, Inc., 2601 Mission Point Blvd., Dayton, Ohio 45431; Air Force Research Laboratory Sensors Directorate, 2241 Avionics Circle, Wright-Patterson AFB, Ohio 45433

2015-04-13

Highly Ga-doped ZnO (GZO) films of thicknesses d = 5, 25, 50, and 300 nm, grown on 160-nm ZnO buffer layers by molecular beam epitaxy, had 294-K Hall-effect mobilities μ{sub H} of 64.1, 43.4, 37.0, and 34.2 cm{sup 2}/V-s, respectively. This extremely unusual ordering of μ{sub H} vs d is explained by the existence of a very high-mobility Debye tail in the ZnO, arising from the large Fermi-level mismatch between the GZO and the ZnO. Scattering theory in conjunction with Poisson analysis predicts a Debye-tail mobility of 206 cm{sup 2}/V-s at the interface (z = d), falling to 58 cm{sup 2}/V-s at z = d + 2 nm. Excellent fits to μ{sub H}more » vs d and sheet concentration n{sub s} vs d are obtained with no adjustable parameters.« less

Extremely efficient flexible organic light-emitting diodes with modified graphene anode

NASA Astrophysics Data System (ADS)

Han, Tae-Hee; Lee, Youngbin; Choi, Mi-Ri; Woo, Seong-Hoon; Bae, Sang-Hoon; Hong, Byung Hee; Ahn, Jong-Hyun; Lee, Tae-Woo

2012-02-01

Although graphene films have a strong potential to replace indium tin oxide anodes in organic light-emitting diodes (OLEDs), to date, the luminous efficiency of OLEDs with graphene anodes has been limited by a lack of efficient methods to improve the low work function and reduce the sheet resistance of graphene films to the levels required for electrodes. Here, we fabricate flexible OLEDs by modifying the graphene anode to have a high work function and low sheet resistance, and thus achieve extremely high luminous efficiencies (37.2 lm W-1 in fluorescent OLEDs, 102.7 lm W-1 in phosphorescent OLEDs), which are significantly higher than those of optimized devices with an indium tin oxide anode (24.1 lm W-1 in fluorescent OLEDs, 85.6 lm W-1 in phosphorescent OLEDs). We also fabricate flexible white OLED lighting devices using the graphene anode. These results demonstrate the great potential of graphene anodes for use in a wide variety of high-performance flexible organic optoelectronics.

Projected Changes to Streamflow Characteristics in Quebec Basins as Simulated by the Canadian Regional Climate Model (CRCM4)

NASA Astrophysics Data System (ADS)

Huziy, O.; Sushama, L.; Khaliq, M.; Lehner, B.; Laprise, R.; Roy, R.

2011-12-01

According to the Intergovernmental Panel on Climate Change (IPCC, 2007), an intensification of the global hydrological cycle and increase in precipitation for some regions around the world, including the northern mid- to high-latitudes, is expected in future climate. This will have an impact on mean and extreme flow characteristics, which need to be assessed for better development of adaptation strategies. Analysis of the mean and extreme streamflow characteristics for Quebec (North-eastern Canada) basins in current climate and their projected changes in future climate are assessed using a 10 member ensemble of current (1970 - 1999) and future (2041 - 2070) Canadian RCM (CRCM4) simulations. Validation of streamflow characteristics, performed by comparing modeled values with those observed, available from the Centre d'expertise hydrique du Quebec (CEHQ) shows that the model captures reasonably well the high flows. Results suggest increase in mean and 10 year return levels of 1 day high flows, which appear significant for most of the northern basins.

Morphology, sex steroid level and gene expression analysis in gonadal sex reversal of triploid female (XXX) rainbow trout (Oncorhynchus mykiss).

PubMed

Xu, Gefeng; Huang, Tianqing; Jin, Xian; Cui, Cunhe; Li, Depeng; Sun, Cong; Han, Ying; Mu, Zhenbo

2016-02-01

In non-mammalian vertebrates, estrogens and expressions of cyp19a1 and foxl2 play critical roles in maintaining ovary differentiation and development, while dmrt1 and sox9 are male-specific genes in testicular differentiation and are highly conserved. In order to deeply understand the morphological change, sex steroids level and molecular mechanism of triploid female gonadal reversal in rainbow trout, we studied the ovary morphology, tendency of estradiol-17β (E2) and testosterone (T) levels and the relative expressions of dmrt1, cyp19a1, sox9 and foxl2 in juvenile and adult fish. Our results demonstrated that the development of triploid female gonads in rainbow trout went through arrested development, oocytes dedifferentiation, ovary reconstruction and sex reversal finally. During early gonadal development (154-334 days post-fertilization), the expressions of foxl2 and cyp19a1 increased linearly, while expressions of dmrt1 and sox9 were extremely suppressed, and E2 level was higher, while T level was lower. During the mid-to-late period of triploid female gonadal development (574-964 days post-fertilization), the expressions of dmrt1 and sox9 remained high and were very close to the quantity of diploid male genes, and T levels were even reaching diploid male plasma concentrations, while expressions of cyp19a1 and foxl2 were decreased, leading to decrease in E2 level. We realized that the development model of rainbow trout triploid female gonads was extremely rare, and the regulatory mechanism was very special. Genes involved in gonadal development and endogenous estrogens are pivotal factors in fish natural sex reversal.

Contrasting Extreme Flooding Events and their Influence on Carbon Dynamics in a Salt Marsh

NASA Astrophysics Data System (ADS)

Vargas, R.; Kowalska, N.; Lule, A. V.; Seyfferth, A.; Reimer, J.; Cai, W. J.; Moffat, C. F.

2017-12-01

Coastal ecosystems are threatened by sea level rise, making them vulnerable to more frequent extreme flooding events. Thus, it is critical to understand the effect of different flooding events on carbon dynamics to test the resiliency of these ecosystems. We used the eddy covariance method to measure CO2 and CH4 fluxes and instrumented an adjacent creek to measure pCO2 and pCH4 in a temperate salt marsh. The site was influenced by flooding caused by a hurricane storm surge and then a freshwater flood during September-October of 2015 and 2016, respectively. Water level, salinity, dissolved oxygen and turbidity were significantly influenced by the events. Daily mean CO2 fluxes show that during the hurricane surge, the ecosystem became a source of CO2 to the atmosphere releasing about 1.8 umol CO2 m-2 s-1 daily. Ecosystem CH4 fluxes were generally low ( 0.05 umol CH4 m-2 s-1) and showed high temporal variability (maximum of 0.6 umol CH4 m-2 s-1). There was an intermittent temporal coherence at 12-hour period (i.e., subdaily tides) between water level and net ecosystem exchange (NEE) or ecosystem CH4 fluxes. There was strong temporal coherence between water level and pCO2 at 12-hour period during the hurricane surge. During the freshwater surge we did not observe temporal coherence between water level and pCO2 or pCH4, but concentrations of both gases increased in the water of the marsh. These results show that extreme flooding events significantly influence short-term carbon dynamics and provide insights on ecosystem resiliency and lateral transport of pCO2 and pCH4 to the coastal ocean.

Vinyl chloride: an assessment of the risk of occupational exposure.

PubMed

Purchase, I F; Stafford, J; Paddle, G M

1987-02-01

There is little doubt that exposure to high levels of VCM as a consequence of occupation can result in an increased incidence of ASL. A review of 20 epidemiological studies involving about 45,000 workers occupationally exposed to VCM showed that neoplasms of the liver showed an increase in incidence in the majority of studies. For brain cancer the association between exposure to VCM and an increased incidence was less clear because of the lower relative risk. Neoplasms of the respiratory tract, digestive system, lymphatic and haemopoietic system, buccal cavity, and pharynx, cardiovascular system and colon/stomach were reported to show an increased incidence in one or more studies, but to show no increase, or in some cases a decrease, in incidence in other studies. In view of the increased incidence of breast neoplasms in rodents exposed to VCM, the studies of Chaizze et al. (1980), who did not confirm these findings in humans, are of importance. The register of ASL cases now contains records of 99 persons with confirmed ASL and occupational exposure to VCM. The average latent period between first exposure to VCM and death from ASL is 21.9 years. The majority of cases occurred in autoclave workers, who are recognized as having been exposed to extremely high levels. Although precise estimates of exposure are not available for the periods of most interest, the pattern of cases roughly suggests that extremely high exposures were necessary for the induction of ASL. For example, ASL cases tended to occur in larger numbers in some plants than in others, a finding that can be explained most easily by differences in exposure patterns. There is an extensive series of animal studies on the carcinogenicity of VCM. Some of these precede the epidemiological studies confirming the association between VCM exposure and ASL in man. ASL and neoplasms of a number of other organs have been induced in laboratory rodents by VCM. Estimation of the exposure levels likely to cause a lifetime risk of ASL of 10(-6) on the basis of these data give extremely low levels (down to 3.9 X 10(-7) ppb) which appear to be unrealistic estimates for man. Part of the reason for this is that laboratory studies have shown that VCM is metabolized in the liver (and elsewhere in the body) to the reactive metabolites chloroethylene oxide and chloroacetaldehyde. The rate of conversion is limited at high levels of exposure giving inaccurate estimates of the slope of the dose-response relationship.(ABSTRACT TRUNCATED AT 400 WORDS)

Influence of turbulence, orientation, and site configuration on the response of buildings to extreme wind.

PubMed

Aly, Aly Mousaad

2014-01-01

Atmospheric turbulence results from the vertical movement of air, together with flow disturbances around surface obstacles which make low- and moderate-level winds extremely irregular. Recent advancements in wind engineering have led to the construction of new facilities for testing residential homes at relatively high Reynolds numbers. However, the generation of a fully developed turbulence in these facilities is challenging. The author proposed techniques for the testing of residential buildings and architectural features in flows that lack fully developed turbulence. While these methods are effective for small structures, the extension of the approach for large and flexible structures is not possible yet. The purpose of this study is to investigate the role of turbulence in the response of tall buildings to extreme winds. In addition, the paper presents a detailed analysis to investigate the influence of upstream terrain conditions, wind direction angle (orientation), and the interference effect from the surrounding on the response of high-rise buildings. The methodology presented can be followed to help decision makers to choose among innovative solutions like aerodynamic mitigation, structural member size adjustment, and/or damping enhancement, with an objective to improve the resiliency and the serviceability of buildings.

Influence of Turbulence, Orientation, and Site Configuration on the Response of Buildings to Extreme Wind

PubMed Central

2014-01-01

Atmospheric turbulence results from the vertical movement of air, together with flow disturbances around surface obstacles which make low- and moderate-level winds extremely irregular. Recent advancements in wind engineering have led to the construction of new facilities for testing residential homes at relatively high Reynolds numbers. However, the generation of a fully developed turbulence in these facilities is challenging. The author proposed techniques for the testing of residential buildings and architectural features in flows that lack fully developed turbulence. While these methods are effective for small structures, the extension of the approach for large and flexible structures is not possible yet. The purpose of this study is to investigate the role of turbulence in the response of tall buildings to extreme winds. In addition, the paper presents a detailed analysis to investigate the influence of upstream terrain conditions, wind direction angle (orientation), and the interference effect from the surrounding on the response of high-rise buildings. The methodology presented can be followed to help decision makers to choose among innovative solutions like aerodynamic mitigation, structural member size adjustment, and/or damping enhancement, with an objective to improve the resiliency and the serviceability of buildings. PMID:24701140

Women live longer than men even during severe famines and epidemics

PubMed Central

Zarulli, Virginia; Barthold Jones, Julia A.; Oksuzyan, Anna; Lindahl-Jacobsen, Rune; Christensen, Kaare; Vaupel, James W.

2018-01-01

Women in almost all modern populations live longer than men. Research to date provides evidence for both biological and social factors influencing this gender gap. Conditions when both men and women experience extremely high levels of mortality risk are unexplored sources of information. We investigate the survival of both sexes in seven populations under extreme conditions from famines, epidemics, and slavery. Women survived better than men: In all populations, they had lower mortality across almost all ages, and, with the exception of one slave population, they lived longer on average than men. Gender differences in infant mortality contributed the most to the gender gap in life expectancy, indicating that newborn girls were able to survive extreme mortality hazards better than newborn boys. Our results confirm the ubiquity of a female survival advantage even when mortality is extraordinarily high. The hypothesis that the survival advantage of women has fundamental biological underpinnings is supported by the fact that under very harsh conditions females survive better than males even at infant ages when behavioral and social differences may be minimal or favor males. Our findings also indicate that the female advantage differs across environments and is modulated by social factors. PMID:29311321

Paleoindian settlement of the high-altitude Peruvian Andes.

PubMed

Rademaker, Kurt; Hodgins, Gregory; Moore, Katherine; Zarrillo, Sonia; Miller, Christopher; Bromley, Gordon R M; Leach, Peter; Reid, David A; Álvarez, Willy Yépez; Sandweiss, Daniel H

2014-10-24

Study of human adaptation to extreme environments is important for understanding our cultural and genetic capacity for survival. The Pucuncho Basin in the southern Peruvian Andes contains the highest-altitude Pleistocene archaeological sites yet identified in the world, about 900 meters above confidently dated contemporary sites. The Pucuncho workshop site [4355 meters above sea level (masl)] includes two fishtail projectile points, which date to about 12.8 to 11.5 thousand years ago (ka). Cuncaicha rock shelter (4480 masl) has a robust, well-preserved, and well-dated occupation sequence spanning the past 12.4 thousand years (ky), with 21 dates older than 11.5 ka. Our results demonstrate that despite cold temperatures and low-oxygen conditions, hunter-gatherers colonized extreme high-altitude Andean environments in the Terminal Pleistocene, within about 2 ky of the initial entry of humans to South America. Copyright © 2014, American Association for the Advancement of Science.

Measuring daily Value-at-Risk of SSEC index: A new approach based on multifractal analysis and extreme value theory

NASA Astrophysics Data System (ADS)

Wei, Yu; Chen, Wang; Lin, Yu

2013-05-01

Recent studies in the econophysics literature reveal that price variability has fractal and multifractal characteristics not only in developed financial markets, but also in emerging markets. Taking high-frequency intraday quotes of the Shanghai Stock Exchange Component (SSEC) Index as example, this paper proposes a new method to measure daily Value-at-Risk (VaR) by combining the newly introduced multifractal volatility (MFV) model and the extreme value theory (EVT) method. Two VaR backtesting techniques are then employed to compare the performance of the model with that of a group of linear and nonlinear generalized autoregressive conditional heteroskedasticity (GARCH) models. The empirical results show the multifractal nature of price volatility in Chinese stock market. VaR measures based on the multifractal volatility model and EVT method outperform many GARCH-type models at high-risk levels.

Case management services for work related upper extremity disorders. Integrating workplace accommodation and problem solving.

PubMed

Shaw, W S; Feuerstein, M; Lincoln, A E; Miller, V I; Wood, P M

2001-08-01

A case manager's ability to obtain worksite accommodations and engage workers in active problem solving may improve health and return to work outcomes for clients with work related upper extremity disorders (WRUEDs). This study examines the feasibility of a 2 day training seminar to help nurse case managers identify ergonomic risk factors, provide accommodation, and conduct problem solving skills training with workers' compensation claimants recovering from WRUEDs. Eight procedural steps to this case management approach were identified, translated into a training workshop format, and conveyed to 65 randomly selected case managers. Results indicate moderate to high self ratings of confidence to perform ergonomic assessments (mean = 7.5 of 10) and to provide problem solving skills training (mean = 7.2 of 10) after the seminar. This training format was suitable to experienced case managers and generated a moderate to high level of confidence to use this case management approach.

Extreme AO coronagraphy laboratory demonstration in the context of SPHERE

NASA Astrophysics Data System (ADS)

Martinez, P.; Aller Carpentier, E.; Kasper, M.

2010-10-01

The exoplanetary science through direct imaging and spectroscopy will largely expand with the very soon raise of new instruments at the VLT (SPHERE), Gemini (GPI), and Subaru (HiCIAO) observatories. All these ground-based adaptive optics instruments include extremely high performance adaptive optics (XAO) system, advanced starlight cancellation techniques (e.g. coronagraphy), and speckle calibration techniques (e.g. spectral, angular, or polarimetry). In this context we report laboratory results obtained with the High-Order Test bench (HOT), the adaptive optics facility at the European Southern Observatory headquarters. Under 0.5 arcsec dynamical seeing, efficiently corrected by an XAO system delivering H-band Strehl ratio above 90%, we discuss contrast levels obtained with an apodized pupil Lyot coronagraph using differential imaging techniques (spectral and polarimetric). Accounting for system differences (e.g. deformable mirror actuator number), we demonstrate a good agreement between experimental results and expectations for SPHERE, or GPI, while we already met HiCIAO contrast goals.

Risk factors for lower extremity injuries in elite female soccer players.

PubMed

Nilstad, Agnethe; Andersen, Thor Einar; Bahr, Roald; Holme, Ingar; Steffen, Kathrin

2014-04-01

The incidence of lower extremity injuries in female soccer players is high, but the risk factors for injuries are unknown. To investigate risk factors for lower extremity injuries in elite female soccer players. Cohort study; Level of evidence, 3. Players in the Norwegian elite female soccer league (N = 12 teams) participated in baseline screening tests before the 2009 competitive soccer season. The screening included tests assessing maximal lower extremity strength, dynamic balance, knee valgus angles in a drop-jump landing, knee joint laxity, generalized joint laxity, and foot pronation. Also included was a questionnaire to collect information on demographic data, elite-level experience, and injury history. Time-loss injuries and exposure in training and matches were recorded prospectively in the subsequent soccer season using weekly text messaging. Players reporting an injury were contacted to collect data regarding injury circumstances. Univariate and multivariate regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for ±1 standard deviation of change. In total, 173 players underwent complete screening tests and registration of injuries and exposure throughout the season. A total of 171 injuries in 107 players (62%) were recorded; ligament and muscle injuries were the most frequent. Multivariate analyses showed that a greater body mass index (BMI) (OR, 1.51; 95% CI, 1.21-1.90; P = .001) was the only factor significantly associated with new lower extremity injuries. A greater BMI was associated with new thigh injuries (OR, 1.51; 95% CI, 1.08-2.11; P = .01), a lower knee valgus angle in a drop-jump landing was associated with new ankle injuries (OR, 0.64; 95% CI, 0.41-1.00; P = .04), and a previous knee injury was associated with new lower leg and foot injuries (OR, 3.57; 95% CI, 1.27-9.99; P = .02), whereas none of the factors investigated influenced the risk of new knee injuries. A greater BMI was associated with lower extremity injuries in elite female soccer players. Increased knowledge on risk factors for lower extremity injuries enables more targeted prevention strategies with the aim of reducing injury rates in female soccer players.

NASA's high-temperature engine materials program for civil aeronautics

NASA Technical Reports Server (NTRS)

Gray, Hugh R.; Ginty, Carol A.

1992-01-01

The Advanced High-Temperature Engine Materials Technology Program is described in terms of its research initiatives and its goal of developing propulsion systems for civil aeronautics with low levels of noise, pollution, and fuel consumption. The program emphasizes the analysis and implementation of structural materials such as polymer-matrix composites in fans, casings, and engine-control systems. Also investigated in the program are intermetallic- and metal-matrix composites for uses in compressors and turbine disks as well as ceramic-matrix composites for extremely high-temperature applications such as turbine vanes.

Future changes in hydro-climatic extremes in the Upper Indus, Ganges, and Brahmaputra River basins

PubMed Central

Lutz, Arthur F.; Nepal, Santosh; Khanal, Sonu; Pradhananga, Saurav; Shrestha, Arun B.; Immerzeel, Walter W.

2017-01-01

Future hydrological extremes, such as floods and droughts, may pose serious threats for the livelihoods in the upstream domains of the Indus, Ganges, Brahmaputra. For this reason, the impacts of climate change on future hydrological extremes is investigated in these river basins. We use a fully-distributed cryospheric-hydrological model to simulate current and future hydrological fluxes and force the model with an ensemble of 8 downscaled General Circulation Models (GCMs) that are selected from the RCP4.5 and RCP8.5 scenarios. The model is calibrated on observed daily discharge and geodetic mass balances. The climate forcing and the outputs of the hydrological model are used to evaluate future changes in climatic extremes, and hydrological extremes by focusing on high and low flows. The outcomes show an increase in the magnitude of climatic means and extremes towards the end of the 21st century where climatic extremes tend to increase stronger than climatic means. Future mean discharge and high flow conditions will very likely increase. These increases might mainly be the result of increasing precipitation extremes. To some extent temperature extremes might also contribute to increasing discharge extremes, although this is highly dependent on magnitude of change in temperature extremes. Low flow conditions may occur less frequently, although the uncertainties in low flow projections can be high. The results of this study may contribute to improved understanding on the implications of climate change for the occurrence of future hydrological extremes in the Hindu Kush–Himalayan region. PMID:29287098

Regional Sea Level Scenarios for Coastal Risk Management: Managing the Uncertainty of Future Sea Level Change and Extreme Water Levels for Department of Defense Coastal Sites Worldwide

DTIC Science & Technology

2016-04-01

SERDP NOAA USACE Ocean MANAGING THE UNCERTAINTY OF FUTURE SEA LEVEL CHANGE AND EXTREME WATER LEVELS FOR DEPARTMENT OF DEFENSE COASTAL SITES...WORLDWIDE APRIL 2016 REGIONAL SEA LEVEL SCENARIOS FOR COASTAL RISK MANAGEMENT: COVER PHOTOS, FROM LEFT TO RIGHT: - Overwash of the island of Roi-Namur on...J.A., S. Gill, J. Obeysekera, W. Sweet, K. Knuuti, and J. Marburger. 2016. Regional Sea Level Scenarios for Coastal Risk Management: Managing the

Corals record long-term Leeuwin current variability including Ningaloo Niño/Niña since 1795

PubMed Central

Zinke, J.; Rountrey, A.; Feng, M.; Xie, S.-P.; Dissard, D.; Rankenburg, K.; Lough, J.M.; McCulloch, M.T.

2014-01-01

Variability of the Leeuwin current (LC) off Western Australia is a footprint of interannual and decadal climate variations in the tropical Indo-Pacific. La Niña events often result in a strengthened LC, high coastal sea levels and unusually warm sea surface temperatures (SSTs), termed Ningaloo Niño. The rarity of such extreme events and the response of the southeastern Indian Ocean to regional and remote climate forcing are poorly understood owing to the lack of long-term records. Here we use well-replicated coral SST records from within the path of the LC, together with a reconstruction of the El Niño-Southern Oscillation to hindcast historical SST and LC strength from 1795 to 2010. We show that interannual and decadal variations in SST and LC strength characterized the past 215 years and that the most extreme sea level and SST anomalies occurred post 1980. These recent events were unprecedented in severity and are likely aided by accelerated global ocean warming and sea-level rise. PMID:24686736

Developing a modified preservative efficacy testing approach as a predictive tool for the evaluation of preservative systems in liquid home care products under variable test conditions.

PubMed

Hoyt, Anne L; Bushman, Don; Lewis, Nathan; Faber, Robert

2012-01-01

How can a formulator have confidence that a preservative system will perform as expected under adverse conditions? Extreme conditions that can lead to the development of "off odors" in the product can be a serious challenge for companies providing home care products in the global market. Formulation and stability testing occur under controlled parameters that simulate limited environmental conditions and microbial challenges are typically performed with a standard inoculum level. While this is an acceptable and dependable process, it does not necessarily assess how well a preservative system can perform under extreme environmental conditions or against unusually high levels of bacterial challenges. This is especially true when formulations are diluted and stored by the end-user. By modifying microbial challenge testing of a liquid dishwashing product to include unexpected dilution schemes, increased microbial assaults, and elevated temperatures, a pattern of preservative efficacy was established. The resulting approach proved to be a useful tool when developing use directions, recommended dilution levels, the overall surfactant system, preservative type, and storage restrictions.

Probabilistic forecasting of extreme weather events based on extreme value theory

NASA Astrophysics Data System (ADS)

Van De Vyver, Hans; Van Schaeybroeck, Bert

2016-04-01

Extreme events in weather and climate such as high wind gusts, heavy precipitation or extreme temperatures are commonly associated with high impacts on both environment and society. Forecasting extreme weather events is difficult, and very high-resolution models are needed to describe explicitly extreme weather phenomena. A prediction system for such events should therefore preferably be probabilistic in nature. Probabilistic forecasts and state estimations are nowadays common in the numerical weather prediction community. In this work, we develop a new probabilistic framework based on extreme value theory that aims to provide early warnings up to several days in advance. We consider the combined events when an observation variable Y (for instance wind speed) exceeds a high threshold y and its corresponding deterministic forecasts X also exceeds a high forecast threshold y. More specifically two problems are addressed:} We consider pairs (X,Y) of extreme events where X represents a deterministic forecast, and Y the observation variable (for instance wind speed). More specifically two problems are addressed: Given a high forecast X=x_0, what is the probability that Y>y? In other words: provide inference on the conditional probability: [ Pr{Y>y|X=x_0}. ] Given a probabilistic model for Problem 1, what is the impact on the verification analysis of extreme events. These problems can be solved with bivariate extremes (Coles, 2001), and the verification analysis in (Ferro, 2007). We apply the Ramos and Ledford (2009) parametric model for bivariate tail estimation of the pair (X,Y). The model accommodates different types of extremal dependence and asymmetry within a parsimonious representation. Results are presented using the ensemble reforecast system of the European Centre of Weather Forecasts (Hagedorn, 2008). Coles, S. (2001) An Introduction to Statistical modelling of Extreme Values. Springer-Verlag.Ferro, C.A.T. (2007) A probability model for verifying deterministic forecasts of extreme events. Wea. Forecasting {22}, 1089-1100.Hagedorn, R. (2008) Using the ECMWF reforecast dataset to calibrate EPS forecasts. ECMWF Newsletter, {117}, 8-13.Ramos, A., Ledford, A. (2009) A new class of models for bivariate joint tails. J.R. Statist. Soc. B {71}, 219-241.

The model test of restoration project of the gravel beach of Chen Village fishing port

NASA Astrophysics Data System (ADS)

Wang, D. X.; Gui, J. S.; Sun, J. W.

2016-08-01

Gravel beach is a case in coastal landform by wave action. It is more and more crucial for the environment of coastal engineering in recent years. However, it is poorly studied for it in China. And this paper which is based on the model test of Restoration Project of the Gravel Beach of Chen Village Fishing Port, uses two dimensional normal physical models, aiming at exploring the movement of gravel beach under wave action and verifying the stability of the gravel beach section. The test depends on different water levels (designed high water level, designed low water level, and extreme high water level) and return periods (2, 5, 10, 25, 50 years once). Finally, two distinct experimental sections are got under the changed conditions and the movement law of gravels is obtained.

Cell wall metabolism and hexose allocation contribute to biomass accumulation in high yielding extreme segregants of a Saccharum interspecific F2 population.

PubMed

Wai, Ching Man; Zhang, Jisen; Jones, Tyler C; Nagai, Chifumi; Ming, Ray

2017-10-11

Sugarcane is an emerging dual-purpose biofuel crop for energy and sugar production, owing to its rapid growth rate, high sucrose storage in the stems, and high lignocellulosic yield. It has the highest biomass production reaching 1.9 billion tonnes in 2014 worldwide. To improve sugarcane biomass accumulation, we developed an interspecific cross between Saccharum officinarum 'LA Purple' and Saccharum robustum 'MOL5829'. Selected F1 individuals were self-pollinated to generate a transgressive F2 population with a wide range of biomass yield. Leaf and stem internodes of fourteen high biomass and eight low biomass F2 extreme segregants were used for RNA-seq to decipher the molecular mechanism of rapid plant growth and dry weight accumulation. Gene Ontology terms involved in cell wall metabolism and carbohydrate catabolism were enriched among 3274 differentially expressed genes between high and low biomass groups. Up-regulation of cellulose metabolism, pectin degradation and lignin biosynthesis genes were observed in the high biomass group, in conjunction with higher transcript levels of callose metabolic genes and the cell wall loosening enzyme expansin. Furthermore, UDP-glucose biosynthesis and sucrose conversion genes were differentially expressed between the two groups. A positive correlation between stem glucose, but not sucrose, levels and dry weight was detected. We thus postulated that the high biomass sugarcane plants rapidly convert sucrose to UDP-glucose, which is the building block of cell wall polymers and callose, in order to maintain the rapid plant growth. The gene interaction of cell wall metabolism, hexose allocation and cell division contributes to biomass yield.

Changes in extremes due to half a degree warming in observations and models

NASA Astrophysics Data System (ADS)

Fischer, E. M.; Schleussner, C. F.; Pfleiderer, P.

2017-12-01

Assessing the climate impacts of half-a-degree warming increments is high on the post-Paris science agenda. Discriminating those effects is particularly challenging for climate extremes such as heavy precipitation and heat extremes for which model uncertainties are generally large, and for which internal variability is so important that it can easily offset or strongly amplify the forced local changes induced by half a degree warming. Despite these challenges we provide evidence for large-scale changes in the intensity and frequency of climate extremes due to half a degree warming. We first assess the difference in extreme climate indicators in observational data for the 1960s and 1970s versus the recent past, two periods differ by half a degree. We identify distinct differences for the global and continental-scale occurrence of heat and heavy precipitation extremes. We show that those observed changes in heavy precipitation and heat extremes broadly agree with simulated historical differences and are informative for the projected differences between 1.5 and 2°C warming despite different radiative forcings. We therefore argue that evidence from the observational record can inform the debate about discernible climate impacts in the light of model uncertainty by providing a conservative estimate of the implications of 0.5°C warming. A limitation of using the observational record arises from potential non-linearities in the response of climate extremes to a certain level of warming. We test for potential non-linearities in the response of heat and heavy precipitation extremes in a large ensemble of transient climate simulations. We further quantify differences between a time-window approach in a coupled model large ensemble vs. time-slice experiments using prescribed SST experiments performed in the context of the HAPPI-MIP project. Thereby we provide different lines of evidence that half a degree warming leads to substantial changes in the expected occurrence of heat and heavy precipitation extremes.

Subtropical air masses over eastern Canada: Their links to extreme precipitation

NASA Astrophysics Data System (ADS)

Gyakum, John; Wood, Alice; Milrad, Shawn; Atallah, Eyad

2017-04-01

We investigate extremely warm, moist air masses with an analysis of 850-hPa equivalent potential temperature (θe) extremes at Montreal, Quebec. The utility of using this metric is that it represents the thermodynamic property of air that ascends during a precipitation event. We produce an analysis of the 40 most extreme cases of positive θe, 10 for each season, based upon standardized anomalies from the 33-year climatology. The analysis shows the cases to be characterized by air masses with distinct subtropical traits for all seasons: reduced static stability, anomalously high precipitable water, and anomalously elevated dynamic tropopause heights. Persistent, slow moving upper- and lower-level features were essential in the build up of high- θe air encompassing much of eastern Canada. The trajectory analysis also showed anticyclonic curvature to all paths in all seasons, implying that the subtropical anticyclone is crucial in the transport of high- θe air. These atmospheric rivers during the winter are characterized by trajectories from the subtropical North Atlantic, and over the Gulf Stream current, northward into Montreal. In contrast, the summer anticyclonic trajectories are primarily continental, traveling from Texas north-northeastward into the Great Lakes, and then eastward into Montreal. The role of the air mass in modulating the strength of a precipitation event is addressed with an analysis of the expression, P = RD, where P is the total precipitation, and R is the precipitation rate, averaged through the duration, D, of the event. Though appearing simple, this expression includes R, (assumed to be same as condensation, with an efficiency of 1), which may be expressed as the product of vertical motion and the change of saturation mixing ratio following a moist adiabat, through the troposphere. This expression for R includes the essential ingredients of lift, air mass temperature, and static stability (implicit in vertical motion). We use this expression for precipitation rate to study the extreme precipitation events in Montreal that are associated with these same cases of extreme warm, moist air masses, and their physical impacts on the precipitation rate. Implications of this air mass modulation on precipitation rate are discussed in the context of longer-term global climate change.

Is prescribed lower extremity weight-bearing status after geriatric lower extremity trauma associated with increased mortality?

PubMed

Gitajn, Ida Leah; Connelly, Daniel; Mascarenhas, Daniel; Breazeale, Stephen; Berger, Peter; Schoonover, Carrie; Martin, Brook; O'Toole, Robert V; Pensy, Raymond; Sciadini, Marcus

2018-02-01

Evaluate whether mortality after discharge is elevated in geriatric fracture patients whose lower extremity weight-bearing is restricted. Retrospective cohort study SETTING: Urban Level 1 trauma center PATIENTS/PARTICIPANTS: 1746 patients >65 years of age INTERVENTION: Post-operative lower extremity weight-bearing status MAIN OUTCOME MEASURE: Mortality, as determined by the Social Security Death Index RESULTS: Univariate analysis demonstrated that patients who were weight-bearing as tolerated on bilateral lower extremities (BLE) had significantly higher 5-year mortality compared to patients with restricted weight-bearing on one lower extremity and restricted weight-bearing on BLE (30%, 21% and 22% respectively, p < 0.001). Cox regression analysis controlling for variables including age, Charlson Comorbidity Index, Injury Severity Scale, combined UE/LE injury, injury mechanism (high vs low), sex, BMI and GCS demonstrated that, in comparison to patients who were weight bearing as tolerated on BLE, restricted weight-bearing on one lower extremity had a hazard ratio (HR) of 0.97 (95% confidence interval 0.78 to 1.20, p = 0.76) and restricted weight-bearing in BLE had a HR of 0.91 (95% confidence interval 0.60 to 1.36, p = 0.73). In geriatric patients, prescribed weight-bearing status did not have a statistically significant association with mortality after discharge, when controlling for age, sex, body mass index, medical comorbidities, Injury Severity Scale (ISS), mechanism of injury, nonoperative treatment and admission GCS. This remained true in when the analysis was restricted to operative injuries only. Copyright © 2017 Elsevier Ltd. All rights reserved.

High-Resolution Regional Reanalysis in China: Evaluation of 1 Year Period Experiments

NASA Astrophysics Data System (ADS)

Zhang, Qi; Pan, Yinong; Wang, Shuyu; Xu, Jianjun; Tang, Jianping

2017-10-01

Globally, reanalysis data sets are widely used in assessing climate change, validating numerical models, and understanding the interactions between the components of a climate system. However, due to the relatively coarse resolution, most global reanalysis data sets are not suitable to apply at the local and regional scales directly with the inadequate descriptions of mesoscale systems and climatic extreme incidents such as mesoscale convective systems, squall lines, tropical cyclones, regional droughts, and heat waves. In this study, by using a data assimilation system of Gridpoint Statistical Interpolation, and a mesoscale atmospheric model of Weather Research and Forecast model, we build a regional reanalysis system. This is preliminary and the first experimental attempt to construct a high-resolution reanalysis for China main land. Four regional test bed data sets are generated for year 2013 via three widely used methods (classical dynamical downscaling, spectral nudging, and data assimilation) and a hybrid method with data assimilation coupled with spectral nudging. Temperature at 2 m, precipitation, and upper level atmospheric variables are evaluated by comparing against observations for one-year-long tests. It can be concluded that the regional reanalysis with assimilation and nudging methods can better produce the atmospheric variables from surface to upper levels, and regional extreme events such as heat waves, than the classical dynamical downscaling. Compared to the ERA-Interim global reanalysis, the hybrid nudging method performs slightly better in reproducing upper level temperature and low-level moisture over China, which improves regional reanalysis data quality.

The Hyperflexible Hip

PubMed Central

Weber, Alexander E.; Bedi, Asheesh; Tibor, Lisa M.; Zaltz, Ira; Larson, Christopher M.

2015-01-01

Context: Dance, gymnastics, figure skating, and competitive cheerleading require a high degree of hip range of motion. Athletes who participate in these sports use their hips in a mechanically complex manner. Evidence Acquisition: A search of the entire PubMed database (through December 2013) and additional searches of the reference lists of pertinent articles. Study Design: Systematic review. Level of Evidence: Level 3. Results: Whether innate or acquired, dancers and gymnasts have some hypermobility that allows their hips to be placed in potentially impinging or unstable positions required for their given activity. Such extremes of motion can result in both intra-articular and extra-articular impingement as well as compensatory osseous and muscular pathology. In addition, dancers and gymnasts are susceptible to impingement-induced instability. Dancers with innate generalized hyperlaxity are at increased risk of injury because of their activities and may require longer recovery times to return to play. Both nonoperative and operative treatments (arthroscopic and open) have an important role in returning flexibility athletes to their preoperative levels of sport and dance. Conclusion: Because of the extreme hip motion required and the compensatory soft tissue laxity in dancers and gymnasts, these athletes may develop instability, impingement, or combinations of both. This frequently occurs in the setting of subtle pathoanatomy or in patients with normal bony anatomy. With appropriate surgical indications and the correct operative technique, the treating surgeon can anticipate high levels of return to play for the gymnast and dancer with hip pain. PMID:26137181

Coping with a challenging environment

PubMed Central

Gesquiere, Laurence R.; Khan, Memuna; Shek, Lili; Wango, Tim L.; Wango, Emmanuel O.; Alberts, Susan C.; Altmann, Jeanne

2008-01-01

Environmental stressors impact physiology and behavior in many species of animals. These effects are partly mediated through changing concentrations of glucocorticoids, which also vary with reproductive state and social conditions. Prior research has focused largely on seasonal breeders, but the close temporal linkage between season and reproductive state in these species hinders ability to disentangle environmental effects from those of the animal’s reproductive status. Here we assessed the effects of environmental challenges on the fecal glucocorticoid (fGC) levels of non-seasonal breeders, female baboons (Papio cynocephalus) of Amboseli, Kenya. Amboseli is characterized by a long dry season, during which food and water become scarce, and by extreme temperatures above 40°C in the shade during some months of the year. We found that after accounting for female reproductive status and individual variability, females exhibited higher fGC levels during the dry season than during the wet season. Further, during the wet season, fGC levels were higher in months of high average daily maximum temperatures. During the dry season, fGC levels were elevated both in hotter months and in months during which the baboons spent a relatively high proportion of time feeding. In spite of these stressors, female baboons reproduce during all months of the year in Amboseli, unlike most other mammals in this environment. This may be attributable to their extreme adaptability, specifically their diversified diet, and their ability to modify their behavior, including their activity profiles. PMID:18514196

Superstrong field science

NASA Astrophysics Data System (ADS)

Tajima, T.; Mourou, G.

2002-04-01

Over the past fifteen years we have seen a surge in our ability to produce high intensities, five to six orders of magnitude higher than was possible before. At these intensities, particles, electrons and protons, acquire kinetic energy in the mega-electron-volt range through interaction with intense laser fields. This opens a new age for the laser, the age of nonlinear relativistic optics coupling even with nuclear physics. We suggest a path to reach an extremely high-intensity level 1026-28 W/cm2 in the coming decade, much beyond the current and near future intensity regime 1023 W/cm2, taking advantage of the megajoule laser facilities. Such a laser at extreme high intensity could accelerate particles to frontiers of high energy, tera-electron-volt and peta-electron-volt, and would become a tool of fundamental physics encompassing particle physics, gravitational physics, nonlinear field theory, ultrahigh-pressure physics, astrophysics, and cosmology. Such a laser intensity may also be very beneficial to an alternative, more direct approach of fast ignition in laser fusion. We suggest a new possibility to explore this. .

Potential defoliation of trees by outbreak populations of gypsy moth in the Chicago area

Treesearch

David W. Onstad; David J. Nowak; Michael R. Jeffords

1997-01-01

The gypsy moth, Lymantria dispar, will soon become established in much of the Midwest. If an outbreak with extremely high population levels of this serious defoliator is allowed to occur in the Chicago area, what kind of damage can be expected? A model for defoliation, refoliation and mortality was developed based on the number of trees and...

International Meeting on Simulation in Healthcare

DTIC Science & Technology

2010-02-01

wounds, burns, and injury . Participants will create reusable moulage items using realistic gel effects materials—designed to work seamlessly with...simulations of injuries and clinical encounters. Such technology provides extremely high levels of perceived realism and encourages suspension of disbelief...trace. The model gives an estimate of the cerebral flow reduction that occurs during early decelerations, including an estimate for vessel diameter

Concept cells through associative learning of high-level representations.

PubMed

Reddy, Leila; Thorpe, Simon J

2014-10-22

In this issue of Neuron, Quian Quiroga et al. (2014) show that neurons in the human medial temporal lobe (MTL) follow subjects' perceptual states rather than the features of the visual input. Patients with MTL damage however have intact perceptual abilities but suffer instead from extreme forgetfulness. Thus, the reported MTL neurons could create new memories of the current perceptual state.

Prader-Willi Syndrome: Parent Perceptions of School, Professional, Social, and Informational Support, and Relations between Support, Child Behavior, and Stress

ERIC Educational Resources Information Center

Lowe-Greenlee, Barbara

2010-01-01

Prader-Willi syndrome (PWS) is a rare genetic disorder that adversely impacts child development and health conditions, and is often associated with significant behavioral challenges. In particular, children with PWS typically exhibit extremely high levels of maladaptive behavior (e.g., excessive food seeking, hording, and binging; temper tantrums;…

The Manifestation of Symmetry between the Emergence of Consciousness and the Development of Competence.

ERIC Educational Resources Information Center

Bierschenk, Bernhard; Bierschenk, Inger

This paper describes an experiment in which 30 students, classified according to high and low analytical performance, were given a reading and text production test to determine their sensibility to the structure of an Icelandic saga. This material was used because of its extreme simplicity on the textual surface level, a property suited for…

Examining the Experiences of a Short Break Scheme amongst Adolescents with Disabilities (Service Users) and Their Parents

ERIC Educational Resources Information Center

Spruin, Elizabeth; Abbott, Nicola; Holt, Nicole

2018-01-01

Globally, families who care for a child or adolescent with disabilities have been found to experience high levels of maternal ill health, stress, depression and family breakdown. In extreme cases, children and adolescents may have to move away from their family to a permanent residential placement. A potentially more appropriate and cost-effective…

Influence of ENSO on coastal flood hazard and exposure at the global-scale

NASA Astrophysics Data System (ADS)

Muis, S.; Haigh, I. D.; Guimarães Nobre, G.; Aerts, J.; Ward, P.

2017-12-01

The El Niño-Southern Oscillation (ENSO) is the dominant signal of interannual climate variability. The unusually warm (El Niño) and cold (La Niña) oceanic and atmospheric conditions in the tropical Pacific drives interannual variability in both mean and extreme sea levels, which in turn may influence the probabilities and impacts of coastal flooding. We assess the influence of ENSO on coastal flood hazard and exposure using daily timeseries from the Global Time and Surge Reanalysis (GTSR) dataset (Muis et al., 2016). As the GTSR timeseries do not include steric effects (i.e. density differences), we improve the GTSR timeseries by adding steric sea levels. Evaluation against observed sea levels shows that the including steric sea levels leads to a much better representation of the seasonal and interannual variability. We show that sea level anomalies occur during ENSO years with higher sea levels during La Niña in the South-Atlantic, Indian Ocean and the West Pacific, whereas sea levels are lower in the east Pacific. The pattern is generally inversed for El Niño. We also find an effect of ENSO in the number of people exposed to coastal flooding. Although the effect is minor at the global-scale, it may be important for flood risk management to consider at the national or sub national levels. Previous studies at the global-scale have used tide gauge observation to assess the influence of ENSO on extreme sea levels. The advantage of our approach over observations is that GTSR provides a consistent dataset with a full global coverage for the period 1979-2014. This allows us to assess ENSO's influence on sea level extremes anywhere in the world. Furthermore, it enables us to also calculate the impacts of extreme sea levels in terms of coastal flooding and exposed population. ReferencesMuis et al (2016) A global reanalysis of storm surges and extreme sea levels. Nature Communications.7:11969. doi:10.1038/ncomms11969.