Relationship between impairments, disability and handicap in reflex sympathetic dystrophy patients: a long-term follow-up study.

PubMed

Geertzen, J H; Dijkstra, P U; van Sonderen, E L; Groothoff, J W; ten Duis, H J; Eisma, W H

1998-10-01

To determine the relationship between impairments, disability and handicap in reflex sympathetic dystrophy (RSD) patients. A long-term follow-up study of upper extremity RSD patients. A university hospital. Sixty-five patients, 3-9 years (mean interval 5.5 years) after RSD of the upper extremity (mean age 50.2 years). Impairments: range of motion, moving two point discrimination, muscle strength of the hand and pain were measured. Disability was assessed with the Groningen Activity Restriction Scale (GARS) and handicap was assessed with three subscales (social functioning, role limitations due to physical problems and role limitations due to emotional problems) of the RAND-36. After RSD of the upper extremity, 62% of the patients are limited in activities of daily living (ADL) and/or instrumental ADL (IADL). Pain and restrictions in forward flexion of the shoulder, thumb opposition and grip strength are the most important impairments limiting ADL and IADL. Patients with limitations in ADL and IADL are significantly more handicapped than patients without limitations. Pain is the most important factor contributing to handicap. The relationship between impairments and disability and between disability and handicap in RSD patients is weak to moderate. Pain is the most important factor leading to disability and handicap.

A Turkish Perspective on Nutrition Education and Preschool Children

ERIC Educational Resources Information Center

Unusan, Nurhan; Sanlier, Nevin

2007-01-01

Preschool education is extremely limited in Turkey, suggesting an absence of public recognition of its importance and a lack of state support. In the "VI. Five Years Development Plan," it was exposed that the target in preschool education could not be reached. Especially, regional differences played an important role. According to…

Rhetoric and Reality: The Role of the Teacher in Shaping a School Sport Programme

ERIC Educational Resources Information Center

Bowles, Richard; O'Sullivan, Mary

2012-01-01

Background: Extra-curricular sport is an important aspect of life in Irish primary schools. Team invasion games hold a dominant position and, within this category, Gaelic games are extremely popular. Teachers have, historically, played a significant role in the promotion of Gaelic games through the organization of inter-school competitions. The…

High-harmonic generation in amorphous solids

DOE Office of Scientific and Technical Information (OSTI.GOV)

You, Yong Sing; Yin, Yanchun; Wu, Yi

High-harmonic generation in isolated atoms and molecules has been widely utilized in extreme ultraviolet photonics and attosecond pulse metrology. Recently, high-harmonic generation has been observed in solids, which could lead to important applications such as all-optical methods to image valance charge density and reconstruct electronic band structures, as well as compact extreme ultraviolet light sources. So far these studies are confined to crystalline solids; therefore, decoupling the respective roles of long-range periodicity and high density has been challenging. Here we report the observation of high-harmonic generation from amorphous fused silica. We also decouple the role of long-range periodicity by comparingmore » harmonics generated from fused silica and crystalline quartz, which contain the same atomic constituents but differ in long-range periodicity. These results advance current understanding of the strong-field processes leading to high-harmonic generation in solids with implications for the development of robust and compact extreme ultraviolet light sources.« less

High-harmonic generation in amorphous solids

DOE PAGES

You, Yong Sing; Yin, Yanchun; Wu, Yi; ...

2017-09-28

High-harmonic generation in isolated atoms and molecules has been widely utilized in extreme ultraviolet photonics and attosecond pulse metrology. Recently, high-harmonic generation has been observed in solids, which could lead to important applications such as all-optical methods to image valance charge density and reconstruct electronic band structures, as well as compact extreme ultraviolet light sources. So far these studies are confined to crystalline solids; therefore, decoupling the respective roles of long-range periodicity and high density has been challenging. Here we report the observation of high-harmonic generation from amorphous fused silica. We also decouple the role of long-range periodicity by comparingmore » harmonics generated from fused silica and crystalline quartz, which contain the same atomic constituents but differ in long-range periodicity. These results advance current understanding of the strong-field processes leading to high-harmonic generation in solids with implications for the development of robust and compact extreme ultraviolet light sources.« less

Current concepts in repair of extremity venous injury.

PubMed

Williams, Timothy K; Clouse, W Darrin

2016-04-01

Extremity venous injury management remains controversial. The purpose of this communication is to offer perspective as well as experiential and technical insight into extremity venous injury repair. Available literature is reviewed and discussed. Historical context is provided. Indication, the decision process for repair, including technical conduct, is delineated. In particular, the authors' experiences in both civilian and wartime injury are used for perspective. Extremity venous injury repair was championed within data from the Vietnam Vascular Registry. However, patterns of extremity venous injury differ between combat and civilian settings. Since Vietnam, civilian descriptive series opine the benefits and potential complications associated with both venous injury repair and ligation. These surround extremity edema, chronic venous insufficiency, thromboembolism, and limb loss. Whereas no clear superiority in either approach has been identified to date, there appears to be no increased risk of pulmonary embolism or chronic venous changes with repair. Newer data from the wars in Iraq and Afghanistan and meta-analysis have reinforced this and also have suggested limb salvage benefit for extremity venous repair in combined arterial and venous injuries in modern settings. The patient's physiologic state and associated injury drive five triage categories suggesting vein injury management. Vein repair thrombosis occurs in a significant proportion, yet many recanalize and possibly have a positive impact on limb venous return. Further, early decompression favors reduced blood loss, acute edema, and inflammation, supporting collateral development. Large soft tissue injury minimizing collateral capacity increases the importance of repair. Constructs of repair are varied with modest differences in patency. Venous shunting is feasible, but specific roles remain nebulous. An aggressive posture toward extremity venous injury repair seems justified today because of the likely role in reducing venous hypertensive sequelae as well as a potential role in limb salvage. Appropriate triage selection for extremity vein repair is essential. Copyright © 2016 Society for Vascular Surgery. All rights reserved.

Role of strangeness to the neutron star mass and cooling

NASA Astrophysics Data System (ADS)

Lee, Chang-Hwan; Lim, Yeunhwan; Hyun, Chang Ho; Kwak, Kyujin

2018-01-01

Neutron star provides unique environments for the investigation of the physics of extreme dense matter beyond normal nuclear saturation density. In such high density environments, hadrons with strange quarks are expected to play very important role in stabilizing the system. Kaons and hyperons are the lowest mass states with strangeness among meson and bayron families, respectively. In this work, we investigate the role of kaons and hyperons to the neutron star mass, and discuss their role in the neutron star cooling.

The Complementary Role of High Sensitivity C-Reactive Protein in the Diagnosis and Severity Assessment of Autism

ERIC Educational Resources Information Center

Khakzad, Mohammad Reza; Javanbakht, Maryam; Shayegan, Mohammad Reza; Kianoush, Sina; Omid, Fatemeh; Hojati, Maryam; Meshkat, Mojtaba

2012-01-01

C-reactive protein (CRP) is a beneficial diagnostic test for the evaluation of inflammatory response. Extremely low levels of CRP can be detected using high-sensitivity CRP (hs-CRP) test. A considerable body of evidence has demonstrated that inflammatory response has an important role in the pathophysiology of autism. In this study, we evaluated…

Testing Students with Learning Disabilities. Assessment Brief. Number 6

ERIC Educational Resources Information Center

Dietel, Ron

2004-01-01

A variety of testing methods can be extremely useful in finding out whether children who are experiencing learning difficulties may have one or more learning disabilities. This is an important and valuable role for testing. Another important issue concerns how best to ensure fairness for a learning disabled student when he or she must take a…

METABOLISM AND METABOLIC ACTIVATION OF CHEMICALS: IN-SILICO SIMULATION

EPA Science Inventory

The role of metabolism in prioritizing chemicals according to their potential adverse health effects is extremely important because innocuous parents can be transformed into toxic metabolites. This work presents the TIssue MEtabolism Simulator (TIMES) platform for simulating met...

Potential role of vegetation dynamics on recent extreme droughts over tropical South America

NASA Astrophysics Data System (ADS)

Wang, G.; Erfanian, A.; Fomenko, L.

2017-12-01

Tropical South America is a drought hot spot. In slightly over a decade (2005-2016), the region encountered three extreme droughts (2005, 2010, and 2016). Recurrent extreme droughts not only impact the region's eco-hydrology and socio-economy, but are also globally important as they can transform the planet's largest rainforest, the Amazon, from a carbon sink to a carbon source. Understanding drought drivers and mechanisms underlying extreme droughts in tropical South America can help better project the fate of the Amazon rainforest in a changing climate. In this study we use a regional climate model (RegCM4.3.4) coupled with a comprehensive land-surface model (CLM4.5) to study the present-day hydroclimate of the region, focusing specifically on what might have caused the frequent recurrence of extreme droughts. In the context of observation natural variability of the global oceanic forcing, we tackle the role of land-atmosphere interactions and ran the model with and without dynamic vegetation to study how vegetation dynamics and carbon-nitrogen cycles may have influenced the drought characteristics. Our results demonstrate skillful simulation of the South American climate in the model, and indicate substantial sensitivity of the region's hydroclimatology to vegetation dynamics. This presentation will compare the role of global oceanic forcing versus regional land surface feedback in the recent recurrent droughts, and will characterize the effects of vegetation dynamics in enhancing the drought severity. Preliminary results on future projections of the regional ecosystem and droughts perspective will be also presented.

An Independent Assessment of Anthropogenic Attribution Statements for Recent Extreme Temperature and Rainfall Events

DOE Office of Scientific and Technical Information (OSTI.GOV)

Angélil, Oliver; Stone, Dáithí; Wehner, Michael

The annual "State of the Climate" report, published in the Bulletin of the American Meteorological Society (BAMS), has included a supplement since 2011 composed of brief analyses of the human influence on recent major extreme weather events. There are now several dozen extreme weather events examined in these supplements, but these studies have all differed in their data sources as well as their approaches to defining the events, analyzing the events, and the consideration of the role of anthropogenic emissions. This study reexamines most of these events using a single analytical approach and a single set of climate model andmore » observational data sources. In response to recent studies recommending the importance of using multiple methods for extreme weather event attribution, results are compared from these analyses to those reported in the BAMS supplements collectively, with the aim of characterizing the degree to which the lack of a common methodological framework may or may not influence overall conclusions. Results are broadly similar to those reported earlier for extreme temperature events but disagree for a number of extreme precipitation events. Based on this, it is advised that the lack of comprehensive uncertainty analysis in recent extreme weather attribution studies is important and should be considered when interpreting results, but as yet it has not introduced a systematic bias across these studies.« less

An Independent Assessment of Anthropogenic Attribution Statements for Recent Extreme Temperature and Rainfall Events

DOE PAGES

Angélil, Oliver; Stone, Dáithí; Wehner, Michael; ...

2016-12-16

The annual "State of the Climate" report, published in the Bulletin of the American Meteorological Society (BAMS), has included a supplement since 2011 composed of brief analyses of the human influence on recent major extreme weather events. There are now several dozen extreme weather events examined in these supplements, but these studies have all differed in their data sources as well as their approaches to defining the events, analyzing the events, and the consideration of the role of anthropogenic emissions. This study reexamines most of these events using a single analytical approach and a single set of climate model andmore » observational data sources. In response to recent studies recommending the importance of using multiple methods for extreme weather event attribution, results are compared from these analyses to those reported in the BAMS supplements collectively, with the aim of characterizing the degree to which the lack of a common methodological framework may or may not influence overall conclusions. Results are broadly similar to those reported earlier for extreme temperature events but disagree for a number of extreme precipitation events. Based on this, it is advised that the lack of comprehensive uncertainty analysis in recent extreme weather attribution studies is important and should be considered when interpreting results, but as yet it has not introduced a systematic bias across these studies.« less

The Role of Comic Reading Materials in Enhancing the Ability to Read in EFL

ERIC Educational Resources Information Center

Roozafzai, Zahra Sadat

2012-01-01

Reading is an extremely active, complex, mental and personal process that concerns both the reader and the text. It is now generally believed that a range of reader with text factors affect the reading process to a considerable extent. So, teachers of EFL need to be aware of the important role of teaching materials. Thus, this study investigated…

Deep sequencing of amplicons reveals widespread intraspecific hybridization and multiple origins of polyploidy in big sagebrush (Artemisia tridentata, Asteraceae)

Treesearch

Bryce A. Richardson; Justin T. Page; Prabin Bajgain; Stewart C. Sanderson; Joshua A. Udall

2012-01-01

Premise of the study: Hybridization has played an important role in the evolution and ecological adaptation of diploid and polyploid plants. Artemisia tridentata (Asteraceae) tetraploids are extremely widespread and of great ecological importance. These tetraploids are often taxonomically identified as A. tridentata subsp. wyomingensis or as autotetraploids of diploid...

Are extreme hydro-meteorological events a prerequisite for extreme water quality impacts? Exploring climate impacts on inland and coastal waters

NASA Astrophysics Data System (ADS)

Michalak, A. M.; Balaji, V.; Del Giudice, D.; Sinha, E.; Zhou, Y.; Ho, J. C.

2017-12-01

Questions surrounding water sustainability, climate change, and extreme events are often framed around water quantity - whether too much or too little. The massive impacts of extreme water quality impairments are equally compelling, however. Recent years have provided a host of compelling examples, with unprecedented harmful algal blooms developing along the West coast, in Utah Lake, in Lake Erie, and off the Florida coast, and huge hypoxic dead zones continuing to form in regions such as Lake Erie, the Chesapeake Bay, and the Gulf of Mexico. Linkages between climate change, extreme events, and water quality impacts are not well understood, however. Several factors explain this lack of understanding, including the relative complexity of underlying processes, the spatial and temporal scale mismatch between hydrologists and climatologists, and observational uncertainty leading to ambiguities in the historical record. Here, we draw on a number of recent studies that aim to quantitatively link meteorological variability and water quality impacts to test the hypothesis that extreme water quality impairments are the result of extreme hydro-meteorological events. We find that extreme hydro-meteorological events are neither always a necessary nor a sufficient condition for the occurrence of extreme water quality impacts. Rather, extreme water quality impairments often occur in situations where multiple contributing factors compound, which complicates both attribution of historical events and the ability to predict the future incidence of such events. Given the critical societal importance of water quality projections, a concerted program of uncertainty reduction encompassing observational and modeling components will be needed to examine situations where extreme weather plays an important, but not solitary, role in the chain of cause and effect.

Understanding Command and Control

DTIC Science & Technology

2006-01-01

and may be stereotyped by role or function. For example, differing degrees of trust may be an initial default depending on whether the relationship is...quality and authenticity become extremely important. Indeed, this type of information sharing allows the users to pull information, which is a genu

Early Detection of Lightning Caused Wildfires and Prediction of Wildfire Behavior through Energy Distribution, Atmospherics, Geophysics, the Sun's Azimuth, and Topology

NASA Astrophysics Data System (ADS)

Giesige, C.; Nava, E.

2016-12-01

In the midst of a changing climate we have seen extremes in weather events: lightning, wildfires, hurricanes, tornadoes, and earthquakes. All of these ride on an imbalance of magnetic and electrical distribution about the earth including what goes on from the atmospheric and geophysic levels. There is relevance to the important role the sun plays in developing and feeding of the extreme weather events along with the sun's role helping to create a separation of charges on earth furthering climactic extremes. Focusing attention in North America and on how the sun, atmospheric and geophysic winds come together producing lightning events, there are connections between energy distribution in the environment, lightning caused wildfires, and extreme wildfire behavior. Lightning caused wildfires and extreme fire behavior have become enhanced with the changing climate conditions. Even with strong developments in wildfire science, there remains a lack in full understanding of connections that create a lightning caused wildfire event and lack of monitoring advancements in predicting extreme fire behavior. Several connections have been made in our research allowing us to connect multiple facets of the environment in regards to electric and magnetic influences on wildfires. Among them include: irradiance, winds, pressure systems, humidity, and topology. The connections can be made to develop better detection systems of wildfires, establish with more accuracy areas of highest risk for wildfire and extreme wildfire behavior, and prediction of wildfire behavior. A platform found within the environment can also lead to further understanding and monitoring of other extreme weather events in the future.

Microbial diversity of extreme habitats in human homes.

PubMed

Savage, Amy M; Hills, Justin; Driscoll, Katherine; Fergus, Daniel J; Grunden, Amy M; Dunn, Robert R

2016-01-01

High-throughput sequencing techniques have opened up the world of microbial diversity to scientists, and a flurry of studies in the most remote and extreme habitats on earth have begun to elucidate the key roles of microbes in ecosystems with extreme conditions. These same environmental extremes can also be found closer to humans, even in our homes. Here, we used high-throughput sequencing techniques to assess bacterial and archaeal diversity in the extreme environments inside human homes (e.g., dishwashers, hot water heaters, washing machine bleach reservoirs, etc.). We focused on habitats in the home with extreme temperature, pH, and chemical environmental conditions. We found a lower diversity of microbes in these extreme home environments compared to less extreme habitats in the home. However, we were nonetheless able to detect sequences from a relatively diverse array of bacteria and archaea. Habitats with extreme temperatures alone appeared to be able to support a greater diversity of microbes than habitats with extreme pH or extreme chemical environments alone. Microbial diversity was lowest when habitats had both extreme temperature and one of these other extremes. In habitats with both extreme temperatures and extreme pH, taxa with known associations with extreme conditions dominated. Our findings highlight the importance of examining interactive effects of multiple environmental extremes on microbial communities. Inasmuch as taxa from extreme environments can be both beneficial and harmful to humans, our findings also suggest future work to understand both the threats and opportunities posed by the life in these habitats.

"The Effect of Alternative Representations of Lake Temperatures and Ice on WRF Regional Climate Simulations"

EPA Science Inventory

Lakes can play a significant role in regional climate, modulating inland extremes in temperature and enhancing precipitation. Representing these effects becomes more important as regional climate modeling (RCM) efforts focus on simulating smaller scales. When using the Weathe...

Utilizing micro simulation to evaluate the safety and efficiency of the expressway system.

DOT National Transportation Integrated Search

2016-08-01

Expressways play a vital role in serving mega-cities, and the safety of expressways : is extremely important. In order to explore the crash mechanisms of expressways, : previous studies have mainly utilized average daily traffic (ADT) as a major cont...

Transit climate change adaptation assessment/asset management pilot for the Metropolitan Atlanta Rapid Transit Authority.

DOT National Transportation Integrated Search

2013-08-01

Public transit agencies play an important role in the provision of safe, reliable, and cost-effective transportation for the communities they serve. With the growing intensity and frequency of extreme weather events, such as hurricanes Irene and Sand...

Source appointment of fine particle number and volume concentration during severe haze pollution in Beijing in January 2013.

PubMed

Liu, Zirui; Wang, Yuesi; Hu, Bo; Ji, Dongsheng; Zhang, Junke; Wu, Fangkun; Wan, Xin; Wang, Yonghong

2016-04-01

Extreme haze episodes repeatedly shrouded Beijing during the winter of 2012-2013, causing major environmental and health problems. To better understand these extreme events, particle number size distribution (PNSD) and particle chemical composition (PCC) data collected in an intensive winter campaign in an urban site of Beijing were used to investigate the sources of ambient fine particles. Positive matrix factorization (PMF) analysis resolved a total of eight factors: two traffic factors, combustion factors, secondary aerosol, two accumulation mode aerosol factors, road dust, and long-range transported (LRT) dust. Traffic emissions (54%) and combustion aerosol (27%) were found to be the most important sources for particle number concentration, whereas combustion aerosol (33%) and accumulation mode aerosol (37%) dominated particle volume concentrations. Chemical compositions and sources of fine particles changed dynamically in the haze episodes. An enhanced role of secondary inorganic species was observed in the formation of haze pollution. Regional transport played an important role for high particles, contribution of which was on average up to 24-49% during the haze episodes. Secondary aerosols from urban background presented the largest contributions (45%) for the rapid increase of fine particles in the severest haze episode. In addition, the invasion of LRT dust aerosols further elevated the fine particles during the extreme haze episode. Our results showed a clear impact of regional transport on the local air pollution, suggesting the importance of regional-scale emission control measures in the local air quality management of Beijing.

Assessing the ability of operational snow models to predict snowmelt runoff extremes (Invited)

NASA Astrophysics Data System (ADS)

Wood, A. W.; Restrepo, P. J.; Clark, M. P.

2013-12-01

In the western US, the snow accumulation and melt cycle of winter and spring plays a critical role in the region's water management strategies. Consequently, the ability to predict snowmelt runoff at time scales from days to seasons is a key input for decisions in reservoir management, whether for avoiding flood hazards or supporting environmental flows through the scheduling of releases in spring, or for allocating releases for multi-state water distribution in dry seasons of year (using reservoir systems to provide an invaluable buffer for many sectors against drought). Runoff forecasts thus have important benefits at both wet and dry extremes of the climatological spectrum. The importance of the prediction of the snow cycle motivates an assessment of the strengths and weaknesses of the US's central operational snow model, SNOW17, in contrast to process-modeling alternatives, as they relate to simulating observed snowmelt variability and extremes. To this end, we use a flexible modeling approach that enables an investigation of different choices in model structure, including model physics, parameterization and degree of spatiotemporal discretization. We draw from examples of recent extreme events in western US watersheds and an overall assessment of retrospective model performance to identify fruitful avenues for advancing the modeling basis for the operational prediction of snow-related runoff extremes.

Fairness in Assessment of English Learners

ERIC Educational Resources Information Center

Abedi, Jamal; Levine, Harold G.

2013-01-01

English language learners (ELLs) face a challenging academic future in learning a new language while simultaneously mastering content in the language they may be struggling to learn. Assessment plays an extremely important role in the academic careers of ELL students, perhaps more so than for native speakers of English. Major changes and…

The 12-Month Pregnancy: Giving Your Baby a Healthy Head Start.

ERIC Educational Resources Information Center

Herman, Barry; Perry, Susan K.

1993-01-01

The weeks just prior to conception and the early weeks of pregnancy are extremely crucial. By adopting a healthy lifestyle, parents can give their babies a head start toward a healthy life. Both men and women play an important role in preconception planning and behavior. (SM)

A New Way for Students and Colleges to Bring about Global Change

ERIC Educational Resources Information Center

Clinton, William Jefferson

2008-01-01

Over the course of history, students and universities have played important, often transformative roles in guiding all people toward a healthier, more equitable, sustainable, and prosperous global community. Today they face unprecedented global challenges relating to climate change, extreme poverty, malnutrition and disease, and equitable…

The role of horizontal thermal advection in regulating wintertime mean and extreme temperatures over the central United States during the past and future

NASA Astrophysics Data System (ADS)

Wang, F.; Vavrus, S. J.

2017-12-01

Horizontal temperature advection plays an especially prominent role in affecting winter climate over continental interiors, where both climatological conditions and extreme weather are strongly regulated by transport of remote air masses. Central North America is one such region, and it experienced a major cold-air outbreak (CAO) a few years ago that some have related to amplified Arctic warming. Despite the known importance of dynamics in shaping the winter climate of this sector and the potential for climate change to modify heat transport, limited attention has been paid to the regional impact of thermal advection. Here, we use a reanalysis product and output from the Community Earth System Model's Large Ensemble to quantify the roles of zonal and meridional temperature advection over the central U. S. during winter, both in the late 20th and 21st centuries. We frame our findings as a "tug of war" between opposing influences of the two advection components and between these dynamical forcings vs. thermodynamic changes under greenhouse warming. For example, Arctic amplification leads to much warmer polar air masses, causing a moderation of cold-air advection into the central U. S., yet the model also simulates a wavier mean circulation and stronger northerly flow during CAOs, favoring lower regional temperatures. We also compare the predominant warming effect of zonal advection and overall cooling effect of meridional temperature advection as an additional tug of war. During both historical and future periods, zonal temperature advection is stronger than meridional advection over the Central U. S. The model simulates a future weakening of both zonal and meridional temperature advection, such that westerly flow provides less warming and northerly flow less cooling. On the most extreme warm days in the past and future, both zonal and meridional temperature advection have positive (warming) contributions. On the most extreme cold days, meridional cold air advection is more important than zonal warm air advection. CAOs in the future feature stronger northerly flow but less extreme temperatures (even relative to the warmer climate), exemplifying the complex competition between thermodynamic and dynamic influences.

Association of lower extremity range of motion and muscle strength with physical performance of community-dwelling older women.

PubMed

Jung, Hungu; Yamasaki, Masahiro

2016-12-08

Reduced lower extremity range of motion (ROM) and muscle strength are related to functional disability in older adults who cannot perform one or more activities of daily living (ADL) independently. The purpose of this study was to determine which factors of seven lower extremity ROMs and two muscle strengths play dominant roles in the physical performance of community-dwelling older women. Ninety-five community-dwelling older women (mean age ± SD, 70.7 ± 4.7 years; age range, 65-83 years) were enrolled in this study. Seven lower extremity ROMs (hip flexion, hip extension, knee flexion, internal and external hip rotation, ankle dorsiflexion, and ankle plantar flexion) and two muscle strengths (knee extension and flexion) were measured. Physical performance tests, including functional reach test (FRT), 5 m gait test, four square step test (FSST), timed up and go test (TUGT), and five times sit-to-stand test (FTSST) were performed. Stepwise regression models for each of the physical performance tests revealed that hip extension ROM and knee flexion strength were important explanatory variables for FRT, FSST, and FTSST. Furthermore, ankle plantar flexion ROM and knee extension strength were significant explanatory variables for the 5 m gait test and TUGT. However, ankle dorsiflexion ROM was a significant explanatory variable for FRT alone. The amount of variance on stepwise multiple regression for the five physical performance tests ranged from 25 (FSST) to 47% (TUGT). Hip extension, ankle dorsiflexion, and ankle plantar flexion ROMs, as well as knee extension and flexion strengths may play primary roles in the physical performance of community-dwelling older women. Further studies should assess whether specific intervention programs targeting older women may achieve improvements in lower extremity ROM and muscle strength, and thereby play an important role in the prevention of dependence on daily activities and loss of physical function, particularly focusing on hip extension, ankle dorsiflexion, and ankle plantar flexion ROMs as well as knee extension and flexion strength.

Role of absorbing aerosols on hot extremes in India in a GCM

NASA Astrophysics Data System (ADS)

Mondal, A.; Sah, N.; Venkataraman, C.; Patil, N.

2017-12-01

Temperature extremes and heat waves in North-Central India during the summer months of March through June are known for causing significant impact in terms of human health, productivity and mortality. While greenhouse gas-induced global warming is generally believed to intensify the magnitude and frequency of such extremes, aerosols are usually associated with an overall cooling, by virtue of their dominant radiation scattering nature, in most world regions. Recently, large-scale atmospheric conditions leading to heat wave and extreme temperature conditions have been analysed for the North-Central Indian region. However, the role of absorbing aerosols, including black carbon and dust, is still not well understood, in mediating hot extremes in the region. In this study, we use 30-year simulations from a chemistry-coupled atmosphere-only General Circulation Model (GCM), ECHAM6-HAM2, forced with evolving aerosol emissions in an interactive aerosol module, along with observed sea surface temperatures, to examine large-scale and mesoscale conditions during hot extremes in India. The model is first validated with observed gridded temperature and reanalysis data, and is found to represent observed variations in temperature in the North-Central region and concurrent large-scale atmospheric conditions during high temperature extremes realistically. During these extreme events, changes in near surface properties include a reduction in single scattering albedo and enhancement in short-wave solar heating rate, compared to climatological conditions. This is accompanied by positive anomalies of black carbon and dust aerosol optical depths. We conclude that the large-scale atmospheric conditions such as the presence of anticyclones and clear skies, conducive to heat waves and high temperature extremes, are exacerbated by absorbing aerosols in North-Central India. Future air quality regulations are expected to reduce sulfate particles and their masking of GHG warming. It is concurrently important to mitigate emissions of warming black carbon particles, to manage future climate change-induced hot extremes.

New options for vascularized bone reconstruction in the upper extremity.

PubMed

Houdek, Matthew T; Wagner, Eric R; Wyles, Cody C; Nanos, George P; Moran, Steven L

2015-02-01

Originally described in the 1970s, vascularized bone grafting has become a critical component in the treatment of bony defects and non-unions. Although well established in the lower extremity, recent years have seen many novel techniques described to treat a variety of challenging upper extremity pathologies. Here the authors review the use of different techniques of vascularized bone grafts for the upper extremity bone pathologies. The vascularized fibula remains the gold standard for the treatment of large bone defects of the humerus and forearm, while also playing a role in carpal reconstruction; however, two other important options for larger defects include the vascularized scapula graft and the Capanna technique. Smaller upper extremity bone defects and non-unions can be treated with the medial femoral condyle (MFC) free flap or a vascularized rib transfer. In carpal non-unions, both pedicled distal radius flaps and free MFC flaps are viable options. Finally, in skeletally immature patients, vascularized fibular head epiphyseal transfer can provide growth potential in addition to skeletal reconstruction.

Hourly storm characteristics along the U.S. West Coast: Role of atmospheric rivers in extreme precipitation

USGS Publications Warehouse

Lamjiri, Maryam A.; Dettinger, Michael; Ralph, F. Martin; Guan, B.

2017-01-01

Gridded hourly precipitation observations over the conterminous U.S., from 1948 to 2002, are analyzed to determine climatological characteristics of storm precipitation totals. Despite generally lower hourly intensities, precipitation totals along the U.S. West Coast (USWC) are comparable to those in southeast U.S. (SEUS). Storm durations, more so than hourly intensities, strongly modulate precipitation-total variability over the USWC, where the correlation coefficients between storm durations and storm totals range from 0.7 to 0.9. Atmospheric rivers (ARs) contribute 30–50% of annual precipitation on the USWC and make such large contributions to extreme storms that 60–100% of the most extreme storms, i.e., storms with precipitation-total return intervals longer than 2 years, are associated with ARs. These extreme storm totals are more strongly tied to storm durations than to storm hourly or average intensities, emphasizing the importance of AR persistence to extreme storms on the USWC.

Exact simulation of max-stable processes.

PubMed

Dombry, Clément; Engelke, Sebastian; Oesting, Marco

2016-06-01

Max-stable processes play an important role as models for spatial extreme events. Their complex structure as the pointwise maximum over an infinite number of random functions makes their simulation difficult. Algorithms based on finite approximations are often inexact and computationally inefficient. We present a new algorithm for exact simulation of a max-stable process at a finite number of locations. It relies on the idea of simulating only the extremal functions, that is, those functions in the construction of a max-stable process that effectively contribute to the pointwise maximum. We further generalize the algorithm by Dieker & Mikosch (2015) for Brown-Resnick processes and use it for exact simulation via the spectral measure. We study the complexity of both algorithms, prove that our new approach via extremal functions is always more efficient, and provide closed-form expressions for their implementation that cover most popular models for max-stable processes and multivariate extreme value distributions. For simulation on dense grids, an adaptive design of the extremal function algorithm is proposed.

Case study: Rainfall partitioning across a natural-to-urban forest gradient during an extreme rain event

NASA Astrophysics Data System (ADS)

Akin, B. H.; Van Stan, J. T., II; Cote, J. F.; Jarvis, M. T.; Underwood, J.; Friesen, J.; Hildebrandt, A.; Maldonado, G.

2017-12-01

Trees' partitioning of rainfall is an important first process along the rainfall-to-runoff pathway that has economically significant influences on urban stormwater management. However, important knowledge gaps exist regarding (1) its role during extreme storms and (2) how this role changes as forest structure is altered by urbanization. Little research has been conducted on canopy rainfall partitioning during large, intense storms, likely because canopy water storage is rapidly overwhelmed (i.e., 1-3 mm) by short duration events exceeding, for example, 80 mm of rainfall. However, canopy structure controls more than just storage; it also affects the time for rain to drain to the surface (becoming throughfall) and the micrometeorological conditions that drive wet canopy evaporation. In fact, observations from an example extreme ( 100 mm with maximum 5-minute intensities exceeding 55 mm/h) storm across a urban-to-natural gradient in pine forests in southeast Georgia (USA), show that storm intensities were differentially dampened by 33% (tree row), 28% (forest fragment), and 17% (natural forests). In addition, maximum wet canopy evaporation rates were higher for the exposed tree row (0.18 mm/h) than for the partially-enclosed fragment canopy (0.14 mm/h) and the closed canopy natural forest site (0.11). This resulted in interception percentages decreasing from urban-to-natural stand structures (25% to 16%). A synoptic analysis of the extreme storm in this case study also shows that the mesoscale meteorological conditions that developed the heavy rainfall is expected to occur more often with projected climate changes.

Sarcoidosis with high serum levels of vascular endothelial growth factor (VEGF), showing RS3PE-like symptoms in extremities.

PubMed

Matsuda, Masayuki; Sakurai, Kumi; Fushimi, Tomohisa; Yamamoto, Kanji; Rokuhara, Shiho; Hosaka, Naritoshi; Ikeda, Shu-ichi

2004-06-01

We report a patient with sarcoidosis who showed edema in the distal portion of all extremities, particularly the legs, as seen in remitting seronegative symmetrical synovitis with pitting edema (RS3PE). Magnetic resonance imaging demonstrated diffuse abnormal intensity in subcutaneous tissues of both legs, and skin biopsy led to a diagnosis of sarcoidosis. Vascular endothelial growth factor (VEGF) showed a high serum level, which decreased soon after starting oral prednisolone, in parallel with an improvement in the limb edema. In this patient VEGF as well as infiltration by sarcoid granuloma in the skin might have played an important role in the pathogenesis of RS3PE-like symptoms in the extremities. When painful pitting edema is seen predominantly in the distal portion of all extremities, sarcoidosis as well as RS3PE should be considered as a possible diagnosis.

The role of the reef-dune system in coastal protection in Puerto Morelos (Mexico)

NASA Astrophysics Data System (ADS)

Franklin, Gemma L.; Torres-Freyermuth, Alec; Medellin, Gabriela; Allende-Arandia, María Eugenia; Appendini, Christian M.

2018-04-01

Reefs and sand dunes are critical morphological features providing natural coastal protection. Reefs dissipate around 90 % of the incident wave energy through wave breaking, whereas sand dunes provide the final natural barrier against coastal flooding. The storm impact on coastal areas with these features depends on the relative elevation of the extreme water levels with respect to the sand dune morphology. However, despite the importance of barrier reefs and dunes in coastal protection, poor management practices have degraded these ecosystems, increasing their vulnerability to coastal flooding. The present study aims to theoretically investigate the role of the reef-dune system in coastal protection under current climatic conditions at Puerto Morelos, located in the Mexican Caribbean Sea, using a widely validated nonlinear non-hydrostatic numerical model (SWASH). Wave hindcast information, tidal level, and a measured beach profile of the reef-dune system in Puerto Morelos are employed to estimate extreme runup and the storm impact scale for current and theoretical scenarios. The numerical results show the importance of including the storm surge when predicting extreme water levels and also show that ecosystem degradation has important implications for coastal protection against storms with return periods of less than 10 years. The latter highlights the importance of conservation of the system as a mitigation measure to decrease coastal vulnerability and infrastructure losses in coastal areas in the short to medium term. Furthermore, the results are used to evaluate the applicability of runup parameterisations for beaches to reef environments. Numerical analysis of runup dynamics suggests that runup parameterisations for reef environments can be improved by including the fore reef slope. Therefore, future research to develop runup parameterisations incorporating reef geometry features (e.g. reef crest elevation, reef lagoon width, fore reef slope) is warranted.

Phosphatidic acid and neurotransmission

PubMed Central

Raben, Daniel M.; Barber, Casey N.

2016-01-01

Lipids play a vital role in the health and functioning of neurons and interest in the physiological role of neuronal lipids is certainly increasing. One neuronal function in which neuronal lipids appears to play key roles in neurotransmission. Our understanding of the role of lipids in the synaptic vesicle cycle and neurotransmitter release is becoming increasingly more important. Much of the initial research in this area has highlighted the major roles played by the phosphoinositides (PtdIns), diacylglycerol (DAG), and phosphatidic acid (PtdOH). Of these, PtdOH has not received as much attention as the other lipids although its role and metabolism appears to be extremely important. This lipid has been shown to play a role in modulating both exocytosis and endocytosis although its precise role in either process is not well defined. The currently evidence suggest this lipid likely participates in key processes by altering membrane architecture necessary for membrane fusion, mediating the penetration of membrane proteins, serving as a precursor for other important SV cycling lipids, or activating essential enzymes. In this review, we address the sources of PtdOH, the enzymes involved in its production, the regulation of these enzymes, and its potential roles in neurotransmission in the central nervous system. PMID:27671966

Tropical storms and the flood hydrology of the central Appalachians

NASA Astrophysics Data System (ADS)

Sturdevant-Rees, Paula; Smith, James A.; Morrison, Julia; Baeck, Mary Lynn

2001-08-01

Flooding from Hurricane Fran is examined as a prototype for central Appalachian flood events that dominate the upper tail of flood peak distributions at basin scales between 100 and 10,000 km2. Hurricane Fran, which resulted in 34 deaths and more than $3.2 billion in damages, made land fall on the North Carolina coast at 0000 UTC, September 6, 1996. By 1200 UTC on September 6, Fran had weakened to a tropical storm, and the center of circulation was located at the North Carolina-Virginia border. Rain bands surrounding the tropical depression produced extreme rainfall and flooding in Virginia and West Virginia, with the most intense rainfall concentrated near ridge tops in the Blue Ridge and Valley and Ridge physiographic provinces. The most severe flooding occurred in the Shenandoah River watershed of Virginia, where peak discharges exceeded the 100-year magnitude at 11 of 19 U.S. Geological Survey stream-gaging stations. The availability of high-resolution discharge and rainfall data sets provides the opportunity to study the hydrologic and hydrometeorological mechanisms associated with extreme floods produced by tropical storms. Analyses indicate that orographie enhancement of tropical storm precipitation plays a central role in the hydrology of extreme floods in the central Appalachian region. The relationships between drainage network structure and storm motion also play a major role in Appalachian flood hydrology. Runoff processes for Hurricane Fran reflected a mixture of saturation excess and infiltration excess mechanisms. Antecedent soil moisture played a significant role in the hydrology of extreme flooding from Hurricane Fran. Land use, in particular, the presence of forest cover, was of secondary importance to the terrain-based distribution of precipitation in determining extreme flood response.

The role of humidity in determining scenarios of perceived temperature extremes in Europe

NASA Astrophysics Data System (ADS)

Scoccimarro, Enrico; Fogli, Pier Giuseppe; Gualdi, Silvio

2017-11-01

An increase of the 2 m temperature over Europe is expected within the current century. In order to consider health impacts, it is important to evaluate the combined effect of temperature and humidity on the human body. To achieve this, projections of a basic index—the humidex—representative of the perceived temperature, under different scenarios and periods, have been investigated. The simultaneous occurrence of observed extreme temperature events and perceived extreme temperature events is seldom found within the present climate, reinforcing the importance of investigating the combination of the two fields. A set of 10 km resolution regional climate simulations, provided within the EURO-CORDEX multi-model effort, demonstrates an ability in representing moderate to extreme events of perceived temperature over the present climate, and to be useful as a tool for quantifying future changes in geographical patterns of exposed areas over Europe. Following the RCP8.5 emission scenario, an expansion of the area subject to dangerous conditions is suggested from the middle of the current century, reaching 60 °N. The most significant increase of perceived extreme temperature conditions is found comparing the 2066-2095 projections to the 1976-2005 period; bearing in mind that changes in relative humidity may either amplify or offset the health effects of temperature, a less pronounced projected reduction of relative humidity in the north-eastern part of Europe, associated with extreme humidex events, makes northern Europe the most prone region to an increase of moderate to extreme values of perceived temperature. This is in agreement with a pronounced projected specific humidity increase.

Youth Labor Markets and the Military. The Rand Paper Series.

ERIC Educational Resources Information Center

Cooper, Richard V. L.

This paper argues that the military plays an extremely important role in youth labor markets by providing not only jobs but also experience and training which can later be transferred to the civilian labor market. Following the introduction, section II examines the military's demand for labor; its fluctuations due to secular, cyclical, and…

A Framework of the Use of Information in Software Testing

ERIC Educational Resources Information Center

Kaveh, Payman

2010-01-01

With the increasing role that software systems play in our daily lives, software quality has become extremely important. Software quality is impacted by the efficiency of the software testing process. There are a growing number of software testing methodologies, models, and initiatives to satisfy the need to improve software quality. The main…

Experiential Learning of Robotics Fundamentals Based on a Case Study of Robot-Assisted Stereotactic Neurosurgery

ERIC Educational Resources Information Center

Faria, Carlos; Vale, Carolina; Machado, Toni; Erlhagen, Wolfram; Rito, Manuel; Monteiro, Sérgio; Bicho, Estela

2016-01-01

Robotics has been playing an important role in modern surgery, especially in procedures that require extreme precision, such as neurosurgery. This paper addresses the challenge of teaching robotics to undergraduate engineering students, through an experiential learning project of robotics fundamentals based on a case study of robot-assisted…

Extremely Ego-Oriented Preservice Teachers' Perspectives on Teaching Physical Education

ERIC Educational Resources Information Center

Todorovich, John R.

2009-01-01

Social constructivists posit that learning involves social interactions among individuals in a given place and time. Since teachers play a significant role in how social interactions are developed and determined in the school classroom, it is important to learn how teachers make decisions about their teaching behaviors and interactions with their…

Role of School Psychologists in Violence Prevention and Intervention

ERIC Educational Resources Information Center

McKellar, Nancy A.; Sherwin, Heather D.

2003-01-01

Kansas school psychologists were extremely accurate in their estimates of violence in their own schools and viewed school violence prevention as an important part of their job, regardless of the rates of violence in their districts. Most had at least some involvement in their own school's violence prevention program, although many reported that…

Psychological and social consequences after reconstruction of upper extremity trauma: methods of detection and management.

PubMed

Galanakos, Spyridon P; Bot, Arjan G J; Zoubos, Aristides B; Soucacos, Panayotis N

2014-03-01

Upper extremity trauma and resulting disability is a stressful event and can affect a patient's personality. Several studies have shown that this injury type has serious psychological and/or social consequences. We systematically reviewed the evidence on the consequences of disability after a complex trauma (combination of soft tissue, osseous, vascular, and nerve involvement) of the upper extremity. We tried to find out the potential crucial factors that could determine the final hand function. In addition, we considered the challenges that need to be addressed to eliminate the adverse or negative effects that arise from upper limb trauma. In the literature, there is a growing interest to study changes in patients' quality of life and return to work. Psychological morbidity is an important part of patients' perceived general health. These issues could play an important role in the final functional outcome of the therapy. An early identification and treatment of trauma-related distress in patients may prevent progression of psychological pathology and mitigate negative effects on general health status. It may be important to evaluate the amount of psychological distress when caring for patients with hand injuries. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Geological hazards: from early warning systems to public health toolkits.

PubMed

Samarasundera, Edgar; Hansell, Anna; Leibovici, Didier; Horwell, Claire J; Anand, Suchith; Oppenheimer, Clive

2014-11-01

Extreme geological events, such as earthquakes, are a significant global concern and sometimes their consequences can be devastating. Geographic information plays a critical role in health protection regarding hazards, and there are a range of initiatives using geographic information to communicate risk as well as to support early warning systems operated by geologists. Nevertheless we consider there to remain shortfalls in translating information on extreme geological events into health protection tools, and suggest that social scientists have an important role to play in aiding the development of a new generation of toolkits aimed at public health practitioners. This viewpoint piece reviews the state of the art in this domain and proposes potential contributions different stakeholder groups, including social scientists, could bring to the development of new toolkits. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Determination Method of Extreme Earthquake Disaster Area Based on the Dust Detection Result from GF-4 Data

NASA Astrophysics Data System (ADS)

Dou, A.; Ding, L.; Chen, M.; Wang, X.

2018-04-01

The remote sensing has played an important role in many earthquake emergencies by rapidly providing the building damage, road damage, landslide and other disaster information. The earthquake in the mountains often caused to the loosening of the mountains and the blowing of the dust in the epicentre area. The dust particles are more serious in the epicentre area than the other disaster area. Basis on the analysis of abnormal spectrum characteristics, the dust detection methods from medium and high resolutions satellite imagery are studied in order to determinate the extreme earthquake disaster area. The results indicate the distribution of extreme disaster can be acquired using the dust detection information from imagery, which can provide great help for disaster intensity assessment.

Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol

PubMed Central

Raghavan, Avanthi; Neeli, Hemanth; Jin, Weijun; Badellino, Karen O.; Demissie, Serkalem; Manning, Alisa K.; DerOhannessian, Stephanie L.; Wolfe, Megan L.; Cupples, L. Adrienne; Li, Mingyao; Kathiresan, Sekar; Rader, Daniel J.

2011-01-01

Genome-wide association studies (GWAS) have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies are being utilized to catalogue the allelic spectrum at GWAS loci. The goal of these studies is to identify causative variants and missing heritability, including heritability due to low frequency and rare alleles with large phenotypic impact. Whereas rare variant efforts have primarily focused on nonsynonymous coding variants, we hypothesized that noncoding variants in these loci are also functionally important. Using the HDL-C gene LIPG as an example, we explored the effect of regulatory variants identified through resequencing of subjects at HDL-C extremes on gene expression, protein levels, and phenotype. Resequencing a portion of the LIPG promoter and 5′ UTR in human subjects with extreme HDL-C, we identified several rare variants in individuals from both extremes. Luciferase reporter assays were used to measure the effect of these rare variants on LIPG expression. Variants conferring opposing effects on gene expression were enriched in opposite extremes of the phenotypic distribution. Minor alleles of a common regulatory haplotype and noncoding GWAS SNPs were associated with reduced plasma levels of the LIPG gene product endothelial lipase (EL), consistent with its role in HDL-C catabolism. Additionally, we found that a common nonfunctional coding variant associated with HDL-C (rs2000813) is in linkage disequilibrium with a 5′ UTR variant (rs34474737) that decreases LIPG promoter activity. We attribute the gene regulatory role of rs34474737 to the observed association of the coding variant with plasma EL levels and HDL-C. Taken together, the findings show that both rare and common noncoding regulatory variants are important contributors to the allelic spectrum in complex trait loci. PMID:22174694

Social roles and the evolution of networks in extreme and isolated environments

NASA Technical Reports Server (NTRS)

Johnson, Jeffrey C.; Boster, James S.; Palinkas, Lawrence A.

2003-01-01

This article reports on the evolution of network structure as it relates to formal and informal social roles in well-bounded, isolated groups. Research was conducted at the Amundsen-Scott South Pole Station. Data were collected on crewmembers' networks of social interaction over each of three winter-over periods, when the station is completely isolated. In addition, data were collected on the informal roles played by crewmembers (e.g., instrumental leadership, expressive leadership). The study found that globally coherent networks in winter-over groups were associated with group consensus on the presence of critically important informal social roles (e.g., expressive leadership) where global coherence is the extent to which a network forms a single group composed of a unitary core and periphery as opposed to being factionalized into two or more subgroups. Conversely, the evolution of multiple subgroups was associated with the absence of consensus on critical informal social roles, above all the critically important role of instrumental leader.

Interjoint coordination of the lower extremities in short-track speed skating.

PubMed

Khuyagbaatar, Batbayar; Purevsuren, Tserenchimed; Park, Won Man; Kim, Kyungsoo; Kim, Yoon Hyuk

2017-10-01

In short-track speed skating, the three-dimensional kinematics of the lower extremities during the whole skating cycle have not been studied. Kinematic parameters of the lower extremities during skating are presented as joint angles versus time. However, the angle-time presentation is not sufficient to describe the relationship between multi-joint movement patterns. Thus, angle-angle presentations were developed and used to describe interjoint coordination in sport activities. In this study, 15 professional male skaters' full body motion data were recorded using a wearable motion capture system during short-track speed skating. We investigated the three-dimensional kinematics of the lower extremities and then established the interjoint coordination between hip-knee and knee-ankle for both legs during the whole skating cycle. The results demonstrate the relationship between multi-joint movements during different phases of short-track speed skating. This study provides fundamentals of the movement mechanism of the lower extremities that can be integrated with physiotherapy to improve skating posture and prevent injuries from repetitive stress since physiological characteristics play an important role in skating performance.

Paediatric Australian bat lyssavirus encephalomyelitis - sequential MRI appearances from symptom onset to death.

PubMed

Shetty, Umesh; Phillips, Mark; Francis, Joshua R; Walsh, Mark

2015-10-01

Human infection with Australian bat lyssavirus is extremely rare. Here we present the craniospinal findings in a fatal case of Australian bat lyssavirus infection in an 8-year-old child. MRI plays a very important role, not only in the diagnostic work-up of Australian bat lyssavirus infection but also in the prognostic assessment.

Assessment of the uncertainty in future projection for summer climate extremes over the East Asia

NASA Astrophysics Data System (ADS)

Park, Changyong; Min, Seung-Ki; Cha, Dong-Hyun

2017-04-01

Future projections of climate extremes in regional and local scales are essential information needed for better adapting to climate changes. However, future projections hold larger uncertainty factors arising from internal and external processes which reduce the projection confidence. Using CMIP5 (Coupled Model Intercomparison Project Phase 5) multi-model simulations, we assess uncertainties in future projections of the East Asian temperature and precipitation extremes focusing on summer. In examining future projection, summer mean and extreme projections of the East Asian temperature and precipitation would be larger as time. Moreover, uncertainty cascades represent wider scenario difference and inter-model ranges with increasing time. A positive mean-extreme relation is found in projections for both temperature and precipitation. For the assessment of uncertainty factors for these projections, dominant uncertainty factors from temperature and precipitation change as time. For uncertainty of mean and extreme temperature, contributions of internal variability and model uncertainty declines after mid-21st century while role of scenario uncertainty grows rapidly. For uncertainty of mean precipitation projections, internal variability is more important than the scenario uncertainty. Unlike mean precipitation, extreme precipitation shows that the scenario uncertainty is expected to be a dominant factor in 2090s. The model uncertainty holds as an important factor for both mean and extreme precipitation until late 21st century. The spatial changes for the uncertainty factors of mean and extreme projections generally are expressed according to temporal changes of the fraction of total variance from uncertainty factors in many grids of the East Asia. ACKNOWLEDGEMENTS The research was supported by the Korea Meteorological Administration Research and Development program under grant KMIPA 2015-2083 and the National Research Foundation of Korea Grant funded by the Ministry of Science, ICT and Future Planning of Korea (NRF-2016M3C4A7952637) for its support and assistant in completion of the study.

Phosphatidic acid and neurotransmission.

PubMed

Raben, Daniel M; Barber, Casey N

2017-01-01

Lipids play a vital role in the health and functioning of neurons and interest in the physiological role of neuronal lipids is certainly increasing. One neuronal function in which neuronal lipids appears to play key roles in neurotransmission. Our understanding of the role of lipids in the synaptic vesicle cycle and neurotransmitter release is becoming increasingly more important. Much of the initial research in this area has highlighted the major roles played by the phosphoinositides (PtdIns), diacylglycerol (DAG), and phosphatidic acid (PtdOH). Of these, PtdOH has not received as much attention as the other lipids although its role and metabolism appears to be extremely important. This lipid has been shown to play a role in modulating both exocytosis and endocytosis although its precise role in either process is not well defined. The currently evidence suggest this lipid likely participates in key processes by altering membrane architecture necessary for membrane fusion, mediating the penetration of membrane proteins, serving as a precursor for other important SV cycling lipids, or activating essential enzymes. In this review, we address the sources of PtdOH, the enzymes involved in its production, the regulation of these enzymes, and its potential roles in neurotransmission in the central nervous system. Copyright © 2016 Elsevier Ltd. All rights reserved.

I know why you voted for Trump: (Over)inferring motives based on choice.

PubMed

Barasz, Kate; Kim, Tami; Evangelidis, Ioannis

2018-05-10

People often speculate about why others make the choices they do. This paper investigates how such inferences are formed as a function of what is chosen. Specifically, when observers encounter someone else's choice (e.g., of political candidate), they use the chosen option's attribute values (e.g., a candidate's specific stance on a policy issue) to infer the importance of that attribute (e.g., the policy issue) to the decision-maker. Consequently, when a chosen option has an attribute whose value is extreme (e.g., an extreme policy stance), observers infer-sometimes incorrectly-that this attribute disproportionately motivated the decision-maker's choice. Seven studies demonstrate how observers use an attribute's value to infer its weight-the value-weight heuristic-and identify the role of perceived diagnosticity: more extreme attribute values give observers the subjective sense that they know more about a decision-maker's preferences, and in turn, increase the attribute's perceived importance. The paper explores how this heuristic can produce erroneous inferences and influence broader beliefs about decision-makers. Copyright © 2018 Elsevier B.V. All rights reserved.

Plant volatiles in extreme terrestrial and marine environments.

PubMed

Rinnan, Riikka; Steinke, Michael; McGenity, Terry; Loreto, Francesco

2014-08-01

This review summarizes the current understanding on plant and algal volatile organic compound (VOC) production and emission in extreme environments, where temperature, water availability, salinity or other environmental factors pose stress on vegetation. Here, the extreme environments include terrestrial systems, such as arctic tundra, deserts, CO₂ springs and wetlands, and marine systems such as sea ice, tidal rock pools and hypersaline environments, with mangroves and salt marshes at the land-sea interface. The emission potentials at fixed temperature and light level or actual emission rates for phototrophs in extreme environments are frequently higher than for organisms from less stressful environments. For example, plants from the arctic tundra appear to have higher emission potentials for isoprenoids than temperate species, and hypersaline marine habitats contribute to global dimethyl sulphide (DMS) emissions in significant amounts. DMS emissions are more widespread than previously considered, for example, in salt marshes and some desert plants. The reason for widespread VOC, especially isoprenoid, emissions from different extreme environments deserves further attention, as these compounds may have important roles in stress resistance and adaptation to extremes. Climate warming is likely to significantly increase VOC emissions from extreme environments both by direct effects on VOC production and volatility, and indirectly by altering the composition of the vegetation. © 2014 John Wiley & Sons Ltd.

The Evolution of Networks in Extreme and Isolated Environment

NASA Technical Reports Server (NTRS)

Johnson, Jeffrey C.; Boster, James S.; Palinkas, Lawrence A.

2000-01-01

This article reports on the evolution of network structure as it relates to the formal and informal aspects of social roles in well bounded, isolated groups. Research was conducted at the Amundsen-Scott South Pole Station over a 3-year period. Data was collected on crewmembers' networks of social interaction and personal advice over each of the 8.5-month winters during a time of complete isolation. In addition, data was collected on informal social role structure (e.g., instrumental leadership, expressive leadership). It was hypothesized that development and maintenance of a cohesive group structure was related to the presence of and group consensus on various informal social roles. The study found that core-periphery structures (i.e., reflecting cohesion) in winter-over groups were associated with the presence of critically important informal social roles (e.g., expressive leadership) and high group consensus on such informal roles. On the other hand, the evolution of clique structures (i.e., lack of cohesion) were associated with the absence of critical roles and a lack of consensus on these roles, particularly the critically important role of instrumental leader.

Synoptic and meteorological drivers of extreme ozone concentrations over Europe

NASA Astrophysics Data System (ADS)

Otero, Noelia Felipe; Sillmann, Jana; Schnell, Jordan L.; Rust, Henning W.; Butler, Tim

2016-04-01

The present work assesses the relationship between local and synoptic meteorological conditions and surface ozone concentration over Europe in spring and summer months, during the period 1998-2012 using a new interpolated data set of observed surface ozone concentrations over the European domain. Along with local meteorological conditions, the influence of large-scale atmospheric circulation on surface ozone is addressed through a set of airflow indices computed with a novel implementation of a grid-by-grid weather type classification across Europe. Drivers of surface ozone over the full distribution of maximum daily 8-hour average values are investigated, along with drivers of the extreme high percentiles and exceedances or air quality guideline thresholds. Three different regression techniques are applied: multiple linear regression to assess the drivers of maximum daily ozone, logistic regression to assess the probability of threshold exceedances and quantile regression to estimate the meteorological influence on extreme values, as represented by the 95th percentile. The relative importance of the input parameters (predictors) is assessed by a backward stepwise regression procedure that allows the identification of the most important predictors in each model. Spatial patterns of model performance exhibit distinct variations between regions. The inclusion of the ozone persistence is particularly relevant over Southern Europe. In general, the best model performance is found over Central Europe, where the maximum temperature plays an important role as a driver of maximum daily ozone as well as its extreme values, especially during warmer months.

Construction of a ratiometric fluorescent probe with an extremely large emission shift for imaging hypochlorite in living cells

NASA Astrophysics Data System (ADS)

Song, Xuezhen; Dong, Baoli; Kong, Xiuqi; Wang, Chao; Zhang, Nan; Lin, Weiying

2018-01-01

Hypochlorite is one of the important reactive oxygen species (ROS) and plays critical roles in many biologically vital processes. Herein, we present a unique ratiometric fluorescent probe (CBP) with an extremely large emission shift for detecting hypochlorite in living cells. Utilizing positively charged α,β-unsaturated carbonyl group as the reaction site, the probe CBP itself exhibited near-infrared (NIR) fluorescence at 662 nm, and can display strong blue fluorescence at 456 nm when responded to hypochlorite. Notably, the extremely large emission shift of 206 nm could enable the precise measurement of the fluorescence peak intensities and ratios. CBP showed high sensitivity, excellent selectivity, desirable performance at physiological pH, and low cytotoxicity. The bioimaging experiments demonstrate the biological application of CBP for the ratiometric imaging of hypochlorite in living cells.

ASSESSMENT OF UPPER EXTREMITY IMPAIRMENT, FUNCTION, AND ACTIVITY FOLLOWING STROKE: FOUNDATIONS FOR CLINICAL DECISION MAKING

PubMed Central

Lang, Catherine E.; Bland, Marghuretta D.; Bailey, Ryan R.; Schaefer, Sydney Y.; Birkenmeier, Rebecca L.

2012-01-01

The purpose of this review is to provide a comprehensive approach for assessing the upper extremity (UE) after stroke. First, common upper extremity impairments and how to assess them are briefly discussed. While multiple UE impairments are typically present after stroke, the severity of one impairment, paresis, is the primary determinant of UE functional loss. Second, UE function is operationally defined and a number of clinical measures are discussed. It is important to consider how impairment and loss of function affect UE activity outside of the clinical environment. Thus, this review also identifies accelerometry as an objective method for assessing UE activity in daily life. Finally, the role that each of these levels of assessment should play in clinical decision making is discussed in order to optimize the provision of stroke rehabilitation services. PMID:22975740

What Does the Acid Ionization Constant Tell You? An Organic Chemistry Student Guide

ERIC Educational Resources Information Center

Rossi, Robert D.

2013-01-01

Many students find the transition from first-year general chemistry to second-year organic chemistry a daunting task. There are many reasons for this, not the least of which is their lack of a solid understanding and appreciation of the importance of some basic concepts and principles from general chemistry that play an extremely critical role in…

Research from the Global South: The Important Role of Context in International Research Activities

ERIC Educational Resources Information Center

Bryant, Katie

2014-01-01

Researchers from various disciplines have become interested in the supposedly extreme differences in rates of research between academics situated in the Global North and South, specifically those on the African continent. Yet, having worked as a researcher and a writing coach in the context of one university in the southern African region for the…

A mutant in the CsDET2 gene leads to a systemic brassinosteriod deficiency and super compact phenotype in cucumber (Cucumis sativus L.)

USDA-ARS?s Scientific Manuscript database

The plant hormone brassinosteroids (BR) plays important roles in the development of plant architecture. Deficiecny of BR in plant may result in extreme dwarfism. Most cucumbers have an indeterminate growth habit, and dwarfism may have it value in manipulation of plant architecture and improve produc...

Key Ecological Roles for Zoosporic True Fungi in Aquatic Habitats.

PubMed

Gleason, Frank H; Scholz, Bettina; Jephcott, Thomas G; van Ogtrop, Floris F; Henderson, Linda; Lilje, Osu; Kittelmann, Sandra; Macarthur, Deborah J

2017-03-01

The diversity and abundance of zoosporic true fungi have been analyzed recently using fungal sequence libraries and advances in molecular methods, such as high-throughput sequencing. This review focuses on four evolutionary primitive true fungal phyla: the Aphelidea, Chytridiomycota, Neocallimastigomycota, and Rosellida (Cryptomycota), most species of which are not polycentric or mycelial (filamentous), rather they tend to be primarily monocentric (unicellular). Zoosporic fungi appear to be both abundant and diverse in many aquatic habitats around the world, with abundance often exceeding other fungal phyla in these habitats, and numerous novel genetic sequences identified. Zoosporic fungi are able to survive extreme conditions, such as high and extremely low pH; however, more work remains to be done. They appear to have important ecological roles as saprobes in decomposition of particulate organic substrates, pollen, plant litter, and dead animals; as parasites of zooplankton and algae; as parasites of vertebrate animals (such as frogs); and as symbionts in the digestive tracts of mammals. Some chytrids cause economically important diseases of plants and animals. They regulate sizes of phytoplankton populations. Further metagenomics surveys of aquatic ecosystems are expected to enlarge our knowledge of the diversity of true zoosporic fungi. Coupled with studies on their functional ecology, we are moving closer to unraveling the role of zoosporic fungi in carbon cycling and the impact of climate change on zoosporic fungal populations.

[Shoulder injuries in golf].

PubMed

Liem, D; Gosheger, G; Schmidt, C

2014-03-01

Due to its growing popularity golf has now come into the focus of orthopedic sports medicine. With a wide range of age groups and playing levels, orthopedic surgeons will encounter a wide range of musculoskeletal problems which are usually the result of overuse rather than trauma. The shoulder joint plays an important role in the golf swing whereby not only the muscles around the glenohumeral joint but also the scapula stabilizing muscles are extremely important for an effective golf swing. Golf is strictly not considered to be an overhead sport; however, the extreme peak positions of the golf swing involve placing the shoulder joint in maximum abduction and adduction positions which can provoke impingement, lesions of the pulley system or even a special form of posterior shoulder instability. Even after complex shoulder operations, such as rotator cuff repair or shoulder arthroplasty, a return to the golf course at nearly the same level of play can be expected.

An overview of the roles and structure of international high-security veterinary laboratories for infectious animal diseases.

PubMed

Murray, P K

1998-08-01

The unique structure, role and operations of government high-security (HS) laboratories which work on animal diseases are described, with particular reference to the laboratories of nine countries. High-security laboratories provide cost-effective insurance against catastrophic losses which could occur following exotic disease outbreaks. The importance of these laboratories is reflected in the fact that several new laboratories have recently been constructed at considerable expense and older facilities have undergone major renovations. Biosecurity is fundamental to the operation of high-security laboratories, so good facility design and microbiological security practices are very important. High-security laboratories conduct exotic disease diagnosis, certification and surveillance, and also perform research into virology, disease pathogenesis and improvements to diagnostic tests and vaccines. The mandate of these laboratories includes the training of veterinarians in the recognition of exotic diseases. One extremely important role is the provision of expert advice on exotic diseases and participation (both nationally and internationally) in policy decisions regarding animal disease issues.

The Influence of Recurrent Modes of Climate Variability on the Occurrence of Monthly Temperature Extremes Over South America

NASA Astrophysics Data System (ADS)

Loikith, Paul C.; Detzer, Judah; Mechoso, Carlos R.; Lee, Huikyo; Barkhordarian, Armineh

2017-10-01

The associations between extreme temperature months and four prominent modes of recurrent climate variability are examined over South America. Associations are computed as the percent of extreme temperature months concurrent with the upper and lower quartiles of the El Niño-Southern Oscillation (ENSO), the Atlantic Niño, the Pacific Decadal Oscillation (PDO), and the Southern Annular Mode (SAM) index distributions, stratified by season. The relationship is strongest for ENSO, with nearly every extreme temperature month concurrent with the upper or lower quartiles of its distribution in portions of northwestern South America during some seasons. The likelihood of extreme warm temperatures is enhanced over parts of northern South America when the Atlantic Niño index is in the upper quartile, while cold extremes are often association with the lowest quartile. Concurrent precipitation anomalies may contribute to these relations. The PDO shows weak associations during December, January, and February, while in June, July, and August its relationship with extreme warm temperatures closely matches that of ENSO. This may be due to the positive relationship between the PDO and ENSO, rather than the PDO acting as an independent physical mechanism. Over Patagonia, the SAM is highly influential during spring and fall, with warm and cold extremes being associated with positive and negative phases of the SAM, respectively. Composites of sea level pressure anomalies for extreme temperature months over Patagonia suggest an important role of local synoptic scale weather variability in addition to a favorable SAM for the occurrence of these extremes.

Sensitivity of UK butterflies to local climatic extremes: which life stages are most at risk?

PubMed

McDermott Long, Osgur; Warren, Rachel; Price, Jeff; Brereton, Tom M; Botham, Marc S; Franco, Aldina M A

2017-01-01

There is growing recognition as to the importance of extreme climatic events (ECEs) in determining changes in species populations. In fact, it is often the extent of climate variability that determines a population's ability to persist at a given site. This study examined the impact of ECEs on the resident UK butterfly species (n = 41) over a 37-year period. The study investigated the sensitivity of butterflies to four extremes (drought, extreme precipitation, extreme heat and extreme cold), identified at the site level, across each species' life stages. Variations in the vulnerability of butterflies at the site level were also compared based on three life-history traits (voltinism, habitat requirement and range). This is the first study to examine the effects of ECEs at the site level across all life stages of a butterfly, identifying sensitive life stages and unravelling the role life-history traits play in species sensitivity to ECEs. Butterfly population changes were found to be primarily driven by temperature extremes. Extreme heat was detrimental during overwintering periods and beneficial during adult periods and extreme cold had opposite impacts on both of these life stages. Previously undocumented detrimental effects were identified for extreme precipitation during the pupal life stage for univoltine species. Generalists were found to have significantly more negative associations with ECEs than specialists. With future projections of warmer, wetter winters and more severe weather events, UK butterflies could come under severe pressure given the findings of this study. © 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.

Relationship between upper extremity kinesthetic sense and writing performance by students with low vision.

PubMed

Aki, Esra; Atasavun, Songül; Kayihan, Holya

2008-06-01

Kinesthetic sense plays an important role in writing. Children with low vision lack sensory input from the environment given their loss of vision. This study assessed the effect of upper extremity kinesthetic sense on writing function in two groups, one of students with low vision (9 girls and 11 boys, 9.4 +/- 1.9 yr. of age) and one of sighted students (10 girls and 10 boys, 10.1 +/- 1.3 yr. of age). All participants were given the Kinesthesia Test and Jebsen Hand Function Test-Writing subtest. Students with low vision scored lower on kinesthetic perception and writing performance than sighted peers. The correlation between scores for writing performance and upper extremity kinesthetic sense in the two groups was significant (r = -.34). The probability of deficiencies in kinesthetic information in students with low vision must be remembered.

Operational early warning platform for extreme meteorological events

NASA Astrophysics Data System (ADS)

Mühr, Bernhard; Kunz, Michael

2015-04-01

Operational early warning platform for extreme meteorological events Most natural disasters are related to extreme weather events (e.g. typhoons); weather conditions, however, are also highly relevant for humanitarian and disaster relief operations during and after other natural disaster like earthquakes. The internet service "Wettergefahren-Frühwarnung" (WF) provides various information on extreme weather events, especially when these events are associated with a high potential for large damage. The main focus of the platform is on Central Europe, but major events are also monitored worldwide on a daily routine. WF provides high-resolution forecast maps for many weather parameters which allow detailed and reliable predictions about weather conditions during the next days in the affected areas. The WF service became operational in February 2004 and is part of the Center for Disaster Management and Risk Reduction Technology (CEDIM) since 2007. At the end of 2011, CEDIM embarked a new type of interdisciplinary disaster research termed as forensic disaster analysis (FDA) in near real time. In case of an imminent extreme weather event WF plays an important role in CEDIM's FDA group. It provides early and precise information which are always available and updated several times during a day and gives advice and assists with articles and reports on extreme events.

Breakfast: a multidisciplinary approach

PubMed Central

2013-01-01

Background The role of breakfast as an essential part of an healthy diet has been only recently promoted even if breakfast practices were known since the Middle Age. The growing scientific evidences on this topic are extremely sector-based nevertheless breakfast could be regarded from different point of views and from different expertises. This approach, that take into account history, sociology, anthropology, medicine, psychology and pedagogy, is useful to better understand the value of this meal in our culture. The aim of this paper was to analyse breakfast-related issues based on a multidisciplinary approach with input by specialists from different fields of learning. Discussion Breakfast is now recommended as part of a diet because it is associated with healthier macro- and micronutrient intakes, body mass index and lifestyle. Moreover recent studies showed that breakfast improves cognitive function, intuitive perception and academic performance. Research demonstrates the importance of providing breakfast not only to children but in adults and elderly too. Although the important role breakfast plays in maintaining the health, epidemiological data from industrialised countries reveal that many individuals either eat a nutritionally unhealthy breakfast or skip it completely. Summary The historical, bio-psychological and educational value of breakfast in our culture is extremely important and should be recognized and stressed by the scientific community. Efforts should be done to promote this practice for the individual health and well-being. PMID:23842429

Role of interventional radiologists in the management of lower extremity venous insufficiency.

PubMed

Hardman, Rulon L; Rochon, Paul J

2013-12-01

Lower extremity venous insufficiency affects over half of all women. Interventional radiologists should be aware of the clinical evaluation of women with venous insufficiency and classification of disease. Endovascular therapies available for treatment of lower extremity venous insufficiency include: endovenous laser ablation, radiofrequency endovascular ablation, and sclerotherapy. The interventional radiologist should be versed on which therapy to select in each clinical presentation and the procedural techniques. The authors review the role of the interventional radiologist in managing this lower extremity venous disorder.

Attribution of Extreme Rainfall from Landfalling Tropical Cyclones to Climate Change for the Eastern United States

NASA Astrophysics Data System (ADS)

Liu, M.; Yang, L.; Smith, J. A.; Vecchi, G. A.

2017-12-01

Extreme rainfall and flooding associated with landfalling tropical cyclones (TC) is responsible for vast socioeconomic losses and fatalities. Landfalling tropical cyclones are an important element of extreme rainfall and flood peak distributions in the eastern United States. Record floods for USGS stream gauging stations over the eastern US are closely tied to landfalling hurricanes. A small number of storms account for the largest record floods, most notably Hurricanes Diane (1955) and Agnes (1972). The question we address is: if the synoptic conditions accompanying those hurricanes were to be repeated in the future, how would the thermodynamic and dynamic storm properties and associated extreme rainfall differ in response to climate change? We examine three hurricanes: Diane (1955), Agnes (1972) and Irene (2011), due to the contrasts in structure/evolution properties and their important roles in dictating the upper tail properties of extreme rainfall and flood frequency over eastern US. Extreme rainfall from Diane is more localized as the storm maintains tropical characteristics, while synoptic-scale vertical motion associated with extratropical transition is a central feature for extreme rainfall induced by Agnes. Our analyses are based on ensemble simulations using the Weather Research and Forecasting (WRF) model, considering combinations of different physics options (i.e., microphysics, boundary layer schemes). The initial and boundary conditions of WRF simulations for the present-day climate are using the Twentieth Century Reanalysis (20thCR). A sub-selection of GCMs is used, as part of phase 5 of the Coupled Model Intercomparison Project (CMIP5), to provide future climate projections. For future simulations, changes in model fields (i.e., temperature, humidity, geopotential height) between present-day and future climate are first derived and then added to the same 20thCR initial and boundary data used for the present-day simulations, and the ensemble is rerun using identical model configurations. Response of extreme rainfall as well as changes in thermodynamic and dynamic storm properties will be presented and analyzed. Contrasting responses across the three storm events to climate change will shed light on critical environmental factors for TC-related extreme rainfall over eastern US.

Daily extreme precipitation indices and their impacts on rice yield—A case study over the tropical island in China

NASA Astrophysics Data System (ADS)

Li, Mao-Fen; Luo, Wei; Li, Hailiang; Liu, Enping; Li, Yuping

2018-04-01

Frequent occurrences of extreme precipitation events have significant impacts on agricultural production. Tropical agriculture has been playing an important role in national economy in China. A precise understanding of variability in extreme precipitation indices and their impacts on crop yields are of great value for farmers and policy makers at county level, particularly in tropical China where almost all agriculture is rainfed. This research has studied observed trends in extreme precipitation indices (a total of 10) during 1988-2013 over Hainan island, tropical China. Mann-Kendall nonparametric test was adopted for trend detection and the results showed that most of precipitation indices showed increasing trend. Since rice is the most important staple food in Hainan island, the impacts of extreme precipitation indices on rice yields were also analyzed through simple correlations. In general, the rainy days and rain intensity in late rice growing season showed increasing trend over Hainan island. The rice yield presented ninth-degree polynomial technological trend at all stations and increasing trend for early rice yield. Late rice yield showed a decreasing trend in some parts of Hainan island. Spearman rank correlation coefficient indicated that the correlation was more pronounced between extreme precipitation indices and yields at Haikou site for early rice, and Haikou, Sanya, and Qionghai stations for late rice, respectively. Further results also indicated that there were statistically significant positive trends of R10 and R20 (number of days with precipitation ≥10 mm and precipitation ≥20 mm, respectively) from July to November at Haikou (located in north of Hainan island), and this positive trend may be a disadvantage for late rice yield. The cut-off value of extreme precipitation indices and its correlation with rice yield anomaly indices for Hainan island provided a foundation for vulnerability assessment as well as a contribution to set up contingency program under potential climate change conditions.

Epidemiological role of birds in the transmission and maintenance of zoonoses.

PubMed

Contreras, A; Gómez-Martín, A; Paterna, A; Tatay-Dualde, J; Prats-Van Der Ham, M; Corrales, J C; De La Fe, C; Sánchez, A

2016-12-01

The risk of zoonoses spreading from birds to humans is lower, quantitatively speaking, than the risk of transmission between other host groups, because the two taxonomic groups share fewer pathogens. Nevertheless, birds have a number of epidemiological characteristics that make them extremely important hosts in the transmission and maintenance of zoonoses, including their susceptibility to pathogens that are extremely hazardous to humans (such as highly pathogenic avian influenza virus, West Nile virus and Chlamydia psittaci) and their ability to travel long distances, especially in the case of migratory birds. The fact that the human diet includes poultry products (meat, eggs and their by-products) also means that most human cases of foodborne zoonoses are infections of avian origin. Lastly, close contact between humans and pet birds or urban birds leads to interactions of public health concern. This article sets out to describe the main factors that determine the role of birds in the epidemiology of zoonotic infections. © OIE (World Organisation for Animal Health), 2016.

Climate extremes and the carbon cycle - a review using an integrated approach with regional examples for forests & native ecosystems -

NASA Astrophysics Data System (ADS)

Frank, D.; Reichstein, M.; Bahn, M.; Beer, C.; Ciais, P.; Mahecha, M.; Seneviratne, S. I.; Smith, P.; van Oijen, M.; Walz, A.

2012-04-01

The terrestrial carbon cycle provides an important biogeochemical feedback to climate and is itself particularly susceptible to extreme climate events. Climate extremes can override any (positive) effects of mean climate change as shown in European and recent US-American heat waves and dry spells. They can impact the structure, composition, and functioning of terrestrial ecosystems and have the potential to cause rapid carbon losses from accumulated stocks. We review how climate extremes like severe droughts, heat waves, extreme precipitation or storms can cause direct impacts on the CO2 fluxes [e.g. due to extreme temperature and/ or drought events] as well as lagged impacts on the carbon cycle [e.g. via an increased fire risk, or disease outbreaks and pest invasions]. The relative impact of the different climate extremes varies according to climate region and vegetation type. We present lagged effects on plant growth (and mortality) in the year(s) following an extreme event and their impacts on the carbon sequestration of forests and natural ecosystems. Comprehensive regional or even continental quantification with regard to extreme events is missing, and especially compound extreme events, the role of lagged effects and aspects of the return frequency are not studied enough. In a case study of a Mediterranean ecosystem we illustrate that the response of the net carbon balance at ecosystem level to regional climate change is hard to predict as interacting and partly compensating processes are affected and several processes which have the ability to substantially alter the carbon balance are not or not sufficiently represented in state-of-the-art biogeochemical models.

Poor caregiver mental health predicts mortality of patients with neurodegenerative disease

PubMed Central

Ford, Brett Q.; Casey, James J.; Miller, Bruce L.; Levenson, Robert W.

2017-01-01

Dementia and other neurodegenerative diseases cause profound declines in functioning; thus, many patients require caregivers for assistance with daily living. Patients differ greatly in how long they live after disease onset, with the nature and severity of the disease playing an important role. Caregiving can also be extremely stressful, and many caregivers experience declines in mental health. In this study, we investigated the role that caregiver mental health plays in patient mortality. In 176 patient–caregiver dyads, we found that worse caregiver mental health predicted greater patient mortality even when accounting for key risk factors in patients (i.e., diagnosis, age, sex, dementia severity, and patient mental health). These findings highlight the importance of caring for caregivers as well as patients when attempting to improve patients’ lives. PMID:28655841

Poor caregiver mental health predicts mortality of patients with neurodegenerative disease.

PubMed

Lwi, Sandy J; Ford, Brett Q; Casey, James J; Miller, Bruce L; Levenson, Robert W

2017-07-11

Dementia and other neurodegenerative diseases cause profound declines in functioning; thus, many patients require caregivers for assistance with daily living. Patients differ greatly in how long they live after disease onset, with the nature and severity of the disease playing an important role. Caregiving can also be extremely stressful, and many caregivers experience declines in mental health. In this study, we investigated the role that caregiver mental health plays in patient mortality. In 176 patient-caregiver dyads, we found that worse caregiver mental health predicted greater patient mortality even when accounting for key risk factors in patients (i.e., diagnosis, age, sex, dementia severity, and patient mental health). These findings highlight the importance of caring for caregivers as well as patients when attempting to improve patients' lives.

North American extreme temperature events and related large scale meteorological patterns: A review of statistical methods, dynamics, modeling, and trends

DOE PAGES

Grotjahn, Richard; Black, Robert; Leung, Ruby; ...

2015-05-22

This paper reviews research approaches and open questions regarding data, statistical analyses, dynamics, modeling efforts, and trends in relation to temperature extremes. Our specific focus is upon extreme events of short duration (roughly less than 5 days) that affect parts of North America. These events are associated with large scale meteorological patterns (LSMPs). Methods used to define extreme events statistics and to identify and connect LSMPs to extreme temperatures are presented. Recent advances in statistical techniques can connect LSMPs to extreme temperatures through appropriately defined covariates that supplements more straightforward analyses. A wide array of LSMPs, ranging from synoptic tomore » planetary scale phenomena, have been implicated as contributors to extreme temperature events. Current knowledge about the physical nature of these contributions and the dynamical mechanisms leading to the implicated LSMPs is incomplete. There is a pressing need for (a) systematic study of the physics of LSMPs life cycles and (b) comprehensive model assessment of LSMP-extreme temperature event linkages and LSMP behavior. Generally, climate models capture the observed heat waves and cold air outbreaks with some fidelity. However they overestimate warm wave frequency and underestimate cold air outbreaks frequency, and underestimate the collective influence of low-frequency modes on temperature extremes. Climate models have been used to investigate past changes and project future trends in extreme temperatures. Overall, modeling studies have identified important mechanisms such as the effects of large-scale circulation anomalies and land-atmosphere interactions on changes in extreme temperatures. However, few studies have examined changes in LSMPs more specifically to understand the role of LSMPs on past and future extreme temperature changes. Even though LSMPs are resolvable by global and regional climate models, they are not necessarily well simulated so more research is needed to understand the limitations of climate models and improve model skill in simulating extreme temperatures and their associated LSMPs. Furthermore, the paper concludes with unresolved issues and research questions.« less

Long-term dead wood changes in a Sierra Nevada mixed conifer forest: habitat and fire hazard implications

Treesearch

Eric E. Knapp

2015-01-01

Dead trees play an important role in forests, with snags and coarse woody debris (CWD) used by many bird and mammal species for nesting, resting, or foraging. However, too much dead wood can also contribute to extreme fire behavior. This tension between dead wood as habitat and dead wood as fuel has raised questions about appropriate quantities in fire-dependent...

Southeast Asia Report

DTIC Science & Technology

1985-08-20

Plays Extremely Important Role (Doan The Nga; GIAO DUC LY LUAN, May-Jun 85) HO LIGHT INDUSTRY Serious Misuse of Electricity Reported ( Tran Kham...GOVERNMENT 96 Speech Outlines Party School Problems (Dao Duy Tung; GIAO DUC LY LUAN, May-Jun 85) 97 Fatherland Front Statement on Peace, Arms...Personalities 127 PUBLICATIONS Table of Contents of TAP CHI GIAO DUC LY LUAN, May-June 1985 ... 133 - e JPRS-SEA-85-128 19 August 1985 INDONESIA

Parent-of-origin growth effects and the evolution of hybrid inviability in dwarf hamsters.

PubMed

Brekke, Thomas D; Good, Jeffrey M

2014-11-01

Mammalian hybrids often show abnormal growth, indicating that developmental inviability may play an important role in mammalian speciation. Yet, it is unclear if this recurrent phenotype reflects a common genetic basis. Here, we describe extreme parent-of-origin-dependent growth in hybrids from crosses between two species of dwarf hamsters, Phodopus campbelli and Phodopus sungorus. One cross type resulted in massive placental and embryonic overgrowth, severe developmental defects, and maternal death. Embryos from the reciprocal cross were viable and normal sized, but adult hybrid males were relatively small. These effects are strikingly similar to patterns from several other mammalian hybrids. Using comparative sequence data from dwarf hamsters and several other hybridizing mammals, we argue that extreme hybrid growth can contribute to reproductive isolation during the early stages of species divergence. Next, we tested if abnormal growth in hybrid hamsters was associated with disrupted genomic imprinting. We found no association between imprinting status at several candidate genes and hybrid growth, though two interacting genes involved in embryonic growth did show reduced expression in overgrown hybrids. Collectively, our study indicates that growth-related hybrid inviability may play an important role in mammalian speciation but that the genetic underpinnings of these phenotypes remain unresolved. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

Disentangling the relative role of climate change on tree growth in an extreme Mediterranean environment.

PubMed

Madrigal-González, Jaime; Andivia, Enrique; Zavala, Miguel A; Stoffel, Markus; Calatayud, Joaquín; Sánchez-Salguero, Raúl; Ballesteros-Cánovas, Juan

2018-06-14

Climate change can impair ecosystem functions and services in extensive dry forests worldwide. However, attribution of climate change impacts on tree growth and forest productivity is challenging due to multiple inter-annual patterns of climatic variability associated with atmospheric and oceanic circulations. Moreover, growth responses to rising atmospheric CO 2 , namely carbon fertilization, as well as size ontogenetic changes can obscure the climate change signature as well. Here we apply Structural Equation Models (SEM) to investigate the relative role of climate change on tree growth in an extreme Mediterranean environment (i.e., extreme in terms of the combination of sandy-unconsolidated soils and climatic aridity). Specifically, we analyzed potential direct and indirect pathways by which different sources of climatic variability (i.e. warming and precipitation trends, the North Atlantic Oscillation, [NAO]; the Mediterranean Oscillation, [MOI]; the Atlantic Mediterranean Oscillation, [AMO]) affect aridity through their control on local climate (in terms of mean annual temperature and total annual precipitation), and subsequently tree productivity, in terms of basal area increments (BAI). Our results support the predominant role of Diameter at Breast Height (DHB) as the main growth driver. In terms of climate, NAO and AMO are the most important drivers of tree growth through their control of aridity (via effects of precipitation and temperature, respectively). Furthermore and contrary to current expectations, our findings also support a net positive role of climate warming on growth over the last 50 years and suggest that impacts of climate warming should be evaluated considering multi-annual and multi-decadal periods of local climate defined by atmospheric and oceanic circulation in the North Atlantic. Copyright © 2018 Elsevier B.V. All rights reserved.

Plastic Surgery Challenges in War Wounded I: Flap-Based Extremity Reconstruction

PubMed Central

Sabino, Jennifer M.; Slater, Julia; Valerio, Ian L.

2016-01-01

Scope and Significance: Reconstruction of traumatic injuries requiring tissue transfer begins with aggressive resuscitation and stabilization. Systematic advances in acute casualty care at the point of injury have improved survival and allowed for increasingly complex treatment before definitive reconstruction at tertiary medical facilities outside the combat zone. As a result, the complexity of the limb salvage algorithm has increased over 14 years of combat activities in Iraq and Afghanistan. Problem: Severe poly-extremity trauma in combat casualties has led to a large number of extremity salvage cases. Advanced reconstructive techniques coupled with regenerative medicine applications have played a critical role in the restoration, recovery, and rehabilitation of functional limb salvage. Translational Relevance: The past 14 years of war trauma have increased our understanding of tissue transfer for extremity reconstruction in the treatment of combat casualties. Injury patterns, flap choice, and reconstruction timing are critical variables to consider for optimal outcomes. Clinical Relevance: Subacute reconstruction with specifically chosen flap tissue and donor site location based on individual injuries result in successful tissue transfer, even in critically injured patients. These considerations can be combined with regenerative therapies to optimize massive wound coverage and limb salvage form and function in previously active patients. Summary: Traditional soft tissue reconstruction is integral in the treatment of war extremity trauma. Pedicle and free flaps are a critically important part of the reconstructive ladder for salvaging extreme extremity injuries that are seen as a result of the current practice of war. PMID:27679751

Educating against Extremism: Towards a Critical Politicisation of Young People

ERIC Educational Resources Information Center

Davies, Lynn

2009-01-01

This paper is based on a recently published book, "Educating Against Extremism" (Davies, "Educating Against Extremism," 2008), which explores the potential role of schools in averting the more negative and violent forms of extremism in a country. It examines the nature of extremism; identity formation and radicalisation; religious belief, faith…

Violent Extremism, Community-Based Violence Prevention, and Mental Health Professionals.

PubMed

Weine, Stevan M; Stone, Andrew; Saeed, Aliya; Shanfield, Stephen; Beahrs, John; Gutman, Alisa; Mihajlovic, Aida

2017-01-01

New community-based initiatives being developed to address violent extremism in the United States are utilizing mental health services and leadership. This article reviews current approaches to preventing violent extremism, the contribution that mental illness and psychosocial problems can make to violent extremism, and the rationale for integrating mental health strategies into preventing violent extremism. The authors describe a community-based targeted violence prevention model and the potential roles of mental health professionals. This model consists of a multidisciplinary team that assesses at-risk individuals with comprehensive threat and behavioral evaluations, arranges for ongoing support and treatment, conducts follow-up evaluations, and offers outreach, education, and resources for communities. This model would enable mental health professionals in local communities to play key roles in preventing violent extremism through their practice and leadership.

The Extreme Male Brain Theory and Gender Role Behaviour in Persons with an Autism Spectrum Condition

ERIC Educational Resources Information Center

Stauder, J. E. A.; Cornet, L. J. M.; Ponds, R. W. H. M.

2011-01-01

According to the Extreme Male Brain theory persons with autism possess masculinised cognitive traits. In this study masculinisation of gender role behaviour is evaluated in 25 persons with an autism spectrum condition (ASC) and matched controls with gender role behaviour as part of a shortened version of the Minnesota Multiphasic Personality…

Spatial distribution of precipitation extremes in Norway

NASA Astrophysics Data System (ADS)

Verpe Dyrrdal, Anita; Skaugen, Thomas; Lenkoski, Alex; Thorarinsdottir, Thordis; Stordal, Frode; Førland, Eirik J.

2015-04-01

Estimates of extreme precipitation, in terms of return levels, are crucial in planning and design of important infrastructure. Through two separate studies, we have examined the levels and spatial distribution of daily extreme precipitation over catchments in Norway, and hourly extreme precipitation in a point. The analyses were carried out through the development of two new methods for estimating extreme precipitation in Norway. For daily precipitation we fit the Generalized Extreme Value (GEV) distribution to areal time series from a gridded dataset, consisting of daily precipitation during the period 1957-today with a resolution of 1x1 km². This grid-based method is more objective and less manual and time-consuming compared to the existing method at MET Norway. In addition, estimates in ungauged catchments are easier to obtain, and the GEV approach includes a measure of uncertainty, which is a requirement in climate studies today. Further, we go into depth on the debated GEV shape parameter, which plays an important role for longer return periods. We show that it varies according to dominating precipitation types, having positive values in the southeast and negative values in the southwest. We also find indications that the degree of orographic enhancement might affect the shape parameter. For hourly precipitation, we estimate return levels on a 1x1 km² grid, by linking GEV distributions with latent Gaussian fields in a Bayesian hierarchical model (BHM). Generalized linear models on the GEV parameters, estimated from observations, are able to incorporate location-specific geographic and meteorological information and thereby accommodate these effects on extreme precipitation. Gaussian fields capture additional unexplained spatial heterogeneity and overcome the sparse grid on which observations are collected, while a Bayesian model averaging component directly assesses model uncertainty. We find that mean summer precipitation, mean summer temperature, latitude, longitude, mean annual precipitation and elevation are good covariate candidates for hourly precipitation in our model. Summer indices succeed because hourly precipitation extremes often occur during the convective season. The spatial distribution of hourly and daily precipitation differs in Norway. Daily precipitation extremes are larger along the southwestern coast, where large-scale frontal systems dominate during fall season and the mountain ridge generates strong orographic enhancement. The largest hourly precipitation extremes are mostly produced by intense convective showers during summer, and are thus found along the entire southern coast, including the Oslo-region.

Elaborating on theory with middle managers' experience implementing healthcare innovations in practice.

PubMed

Birken, Sarah A; DiMartino, Lisa D; Kirk, Meredith A; Lee, Shoou-Yih D; McClelland, Mark; Albert, Nancy M

2016-01-04

The theory of middle managers' role in implementing healthcare innovations hypothesized that middle managers influence implementation effectiveness by fulfilling the following four roles: diffusing information, synthesizing information, mediating between strategy and day-to-day activities, and selling innovation implementation. The theory also suggested several activities in which middle managers might engage to fulfill the four roles. The extent to which the theory aligns with middle managers' experience in practice is unclear. We surveyed middle managers (n = 63) who attended a nursing innovation summit to (1) assess alignment between the theory and middle managers' experience in practice and (2) elaborate on the theory with examples from middle managers' experience overseeing innovation implementation in practice. Middle managers rated all of the theory's hypothesized four roles as "extremely important" but ranked diffusing and synthesizing information as the most important and selling innovation implementation as the least important. They reported engaging in several activities that were consistent with the theory's hypothesized roles and activities such as diffusing information via meetings and training. They also reported engaging in activities not described in the theory such as appraising employee performance. Middle managers' experience aligned well with the theory and expanded definitions of the roles and activities that it hypothesized. Future studies should assess the relationship between hypothesized roles and the effectiveness with which innovations are implemented in practice. If evidence supports the theory, the theory should be leveraged to promote the fulfillment of hypothesized roles among middle managers, doing so may promote innovation implementation.

Research on vacuum utraviolet calibration technology

NASA Astrophysics Data System (ADS)

Wang, Jiapeng; Gao, Shumin; Sun, Hongsheng; Chen, Yinghang; Wei, Jianqiang

2014-11-01

Importance of extreme ultraviolet (EUV) and far ultraviolet (FUV) calibration is growing fast as vacuum ultraviolet payloads are wildly used in national space plan. A calibration device is established especially for the requirement of EUV and FUV metrology and measurement. Spectral radiation and detector relative spectral response at EUV and FUV wavelengths can be calibrated with accuracy of 26% and 20%, respectively. The setup of the device, theoretical model and value retroactive method are introduced and measurement of detector relative spectral response from 30 nm to 200 nm is presented in this paper. The calibration device plays an important role in national space research.

Didactic Dissonance: Teacher Roles in Computer Gaming Situations in Kindergartens

ERIC Educational Resources Information Center

Vangsnes, Vigdis; Økland, Nils Tore Gram

2015-01-01

In computer gaming situations in kindergartens, the pre-school teacher's function can be viewed in a continuum. At one extreme is the teacher who takes an intervening role and at the other extreme is the teacher who chooses to restrict herself/himself to an organising or distal role. This study shows that both the intervening position and the…

Integrating Climate Change Into Nursing Curricula.

PubMed

McDermott-Levy, Ruth; Jackman-Murphy, Kathryn P; Leffers, Jeanne M; Jordan, Lisa

2018-03-28

Climate change is a significant threat to human health across the life cycle. Nurses play an important role in mitigation, adaptation, and resilience to climate change. The use of health care resources, air quality and extreme heat, mental health, and natural disasters are major content areas across undergraduate nursing curricula that influence or are influenced by climate change. Teaching strategies and resources are offered to prepare nursing students to address climate change and human health.

Northern Eurasian Heat Waves and Droughts

NASA Technical Reports Server (NTRS)

Schubert, Siegfried; Wang, Hailan; Koster, Randal; Suarez, Max; Groisman, Pavel

2013-01-01

This article reviews our understanding of the characteristics and causes of northern Eurasian summertime heat waves and droughts. Additional insights into the nature of temperature and precipitation variability in Eurasia on monthly to decadal time scales and into the causes and predictability of the most extreme events are gained from the latest generation of reanalyses and from supplemental simulations with the NASA GEOS-5 AGCM. Key new results are: 1) the identification of the important role of summertime stationary Rossby waves in the development of the leading patterns of monthly Eurasian surface temperature and precipitation variability (including the development of extreme events such as the 2010 Russian heat wave), 2) an assessment of the mean temperature and precipitation changes that have occurred over northern Eurasia in the last three decades and their connections to decadal variability and global trends in SST, and 3) the quantification (via a case study) of the predictability of the most extreme simulated heat wave/drought events, with some focus on the role of soil moisture in the development and maintenance of such events. A literature survey indicates a general consensus that the future holds an enhanced probability of heat waves across northern Eurasia, while there is less agreement regarding future drought, reflecting a greater uncertainty in soil moisture and precipitation projections. Substantial uncertainties remain in our understanding of heat waves and drought, including the nature of the interactions between the short-term atmospheric variability associated with such extremes and the longer-term variability and trends associated with soil moisture feedbacks, SST anomalies, and an overall warming world.

The Role of Exercise in Prevention and Treatment of Osteopenia of Prematurity: An Update.

PubMed

Eliakim, Alon; Litmanovitz, Ita; Nemet, Dan

2017-11-01

Premature infants have an increased risk of osteopenia due to limited bone mass accretion in utero and a greater need for bone nutrients. Until recently, most efforts to prevent osteopenia of prematurity focused on nutritional changes. Recent studies indicate that passive range-of-motion exercise of the extremities may lead to beneficial effects on body weight, increased bone mineralization, increased bone formation markers and leptin levels, and attenuation of the natural postnatal decline in bone speed of sound. These results suggest that exercise may play an important role in the prevention and treatment of osteopenia of prematurity. This review summarizes our current knowledge on the role of exercise in the prevention and treatment of osteopenia of prematurity.

Eddy covarianace measurements in a hyper-arid and hyper-saline mangroves ecosystem

NASA Astrophysics Data System (ADS)

Perri, S.; Marpu, P.; Molini, A.; Armstrong, P.

2017-12-01

The natural environment of mangroves provides a number of ecosystem services for improving water quality, supporting healthy fisheries, and protecting the coasts. Also, their carbon storage is larger than any other forest type. Several authors have recognized the importance of mangroves in global carbon cycles. However, energy, water and carbon exchanges between ecosystem and atmosphere are still not completely understood. Eddy covariance measurements are extremely valuable to understand the role of the unique stressors of costal ecosystems in gas exchange. In particular, periodic flooding and elevated soil pore water salinity influence land-atmosphere interactions. Despites the importance of flux measurements in mangroves forests, such in-situ observations are extremely rare. Our research team set up an eddy covariance tower in the Mangrove National Park of Abu Dhabi, UAE. The study site (24.4509° N, 54.4288° E) is located in a dwarf Avicennia marina ecosystem experiencing extremely high temperatures and salinity. CO2 and H2O exchanges are estimated and related to water level and salinity measurements. This unique dataset will shed some light on the net ecosystem exchange (NEE) of carbon dioxide, on energy fluxes and on evapotranspiration rates for a halophyte ecosystem under severe salt-stress and high temperature.

Characterising Atlantic deep waters during the extreme warmth of the early Eocene 'greenhouse'.

NASA Astrophysics Data System (ADS)

Cameron, A.; Sexton, P. F.; Anand, P.; Huck, C. E.; Fehr, M.; Dickson, A.; Scher, H. D.; van de Flierdt, T.; Westerhold, T.; Roehl, U.

2014-12-01

The meridional overturning circulation (MOC) is a planetary-scale oceanic flow that is of direct importance to the climate system because it transports heat, salt and nutrients to high latitudes and regulates the exchange of CO2 with the atmosphere. The Atlantic Ocean plays a strong role in the modern day MOC however, it is unclear what role it may have played during extreme climate conditions such as those found in the early Eocene 'greenhouse'. In order to resolve the Atlantic's role in the MOC during the early/middle Eocene, we present a multi-proxy approach to investigate changes in ocean circulation, water mass geometry, sediment supply to the deep oceans and the physical strength of deep waters from four different IODP drill sites. Neodymium isotopes (ɛNd), REE profiles and cerium anomalies measured in fossilised fish teeth help to characterise geochemical changes to water masses throughout the Atlantic whilst bulk sediment ɛNd and XRF-core scan data documents changes in sediment supply to the region. Sortable silt data provides a physical constraint on the strength of deep-water movements during the extreme climatic conditions of the early Eocene. We utilise expanded and continuous sequences from two sites in the North west Atlantic spanning the early to middle Eocene recently recovered on IODP Exp. 342 (1403, 1409) that are located on the Newfoundland Ridge, directly in the flow path of today's Deep Western Boundary Current. We also present data from equatorial Demerara Rise (IODP site 1258) and from further north at the mouth of the Labrador Sea (ODP Site 647).

The prehistory of the Arabian peninsula: deserts, dispersals, and demography.

PubMed

Groucutt, Huw S; Petraglia, Michael D

2012-05-01

As a geographic connection between Africa and the rest of Eurasia, the Arabian Peninsula occupies a central position in elucidating hominin evolution and dispersals. Arabia has been characterized by extreme environmental fluctuation in the Quaternary, with profound evolutionary and demographic consequences. Despite the importance of the region, Arabia remains understudied. Recent years, however, have seen major developments in environmental studies and archeology, revealing that the region contains important records that should play a significant role in future paleoanthropological narratives.(1-3) The emerging picture of Arabia suggests that numerous dispersals of hominin populations into the region occurred. Populations subsequently followed autochthonous trajectories, creating a distinctive regional archeological record. Debates continue on the respective roles of regional hominin extinctions and population continuity, with the latter suggesting adaptation to arid conditions. Copyright © 2012 Wiley Periodicals, Inc.

The Response of Different Audiences to Place-based Communication about the Role of Climate Change in Extreme Weather Events

NASA Astrophysics Data System (ADS)

Halperin, A.; Walton, P.

2015-12-01

As the science of extreme event attribution grows, there is an increasing need to understand how the public responds to this type of climate change communication. Extreme event attribution has the unprecedented potential to locate the effects of climate change in the here and now, but there is little information about how different facets of the public might respond to these local framings of climate change. Drawing on theories of place attachment and psychological distance, this paper explores how people with different beliefs and values shift their willingness to mitigate and adapt to climate change in response to local or global communication of climate change impacts. Results will be presented from a recent survey of over 600 Californians who were each presented with one of three experimental conditions: 1) a local framing of the role of climate change in the California drought 2) a global framing of climate change and droughts worldwide, or 3) a control condition of no text. Participants were categorized into groups based on their prior beliefs about climate change according to the Six Americas classification scheme (Leiserowitz et al., 2011). The results from the survey in conjunction with qualitative results from follow-up interviews shed insight into the importance of place in communicating climate change for people in each of the Six Americas. Additional results examine the role of gender and political affiliation in mediating responses to climate change communication. Despite research that advocates unequivocally for local framing of climate change, this study offers a more nuanced perspective of under which circumstances extreme event attribution might be an effective tool for changing behaviors. These results could be useful for scientists who wish to gain a better understanding of how their event attribution research is perceived or for educators who want to target their message to audiences where it could have the most impact.

Psychological and Physical Impacts of Extreme Events on Older Adults: Implications for Communications.

PubMed

McClelland, Erin; Amlôt, Richard; Rogers, M Brooke; Rubin, G James; Tesh, John; Pearce, Julia M

2017-02-01

In recent years, a series of large-scale, high-profile natural disasters and terrorist attacks have demonstrated the need for thorough and effective disaster preparedness. While these extreme events affect communities and societies as a whole, they also carry specific risks for particular population groups. Crises such as Hurricane Katrina and the 2011 earthquake and tsunami disaster in Japan have illustrated the risk of significant and disproportionate morbidity and mortality among older adults during disasters. Age does not necessarily equate to vulnerability, but many physical and psychological consequences of the aging process can increase the risk of adverse outcomes. As the older population grows, so too does the need to ensure that adequate, practical, and appropriate measures exist to offset the specific risks from extreme events associated with this subpopulation. Effective risk and crisis communication plays a key role in mitigating the extent to which older adults are differentially affected during extreme events. By identifying the specific issues affecting older adults, this review highlights important areas for action for practitioners and policy-makers, particularly in the realm of crisis communication. (Disaster Med Public Health Preparedness. 2017;11:127-134).

Isolation and characterization of Ferroplasma thermophilum sp. nov., a novel extremely acidophilic, moderately thermophilic archaeon and its role in bioleaching of chalcopyrite.

PubMed

Zhou, H; Zhang, R; Hu, P; Zeng, W; Xie, Y; Wu, C; Qiu, G

2008-08-01

To isolate Ferroplasma thermophilum L1(T) from a low pH environment and to understand its role in bioleaching of chalcopyrite. Using serial dilution method, a moderately thermophilic and acidophilic ferrous iron-oxidizing archaeon, named L1(T), was isolated from a chalcopyrite-leaching bioreactor. The morphological, biochemical and physiological characteristics of strain L1(T) and its role in bioleaching of chalcopyrite were studied. Strain L1(T) was a nonmotile coccus that lacked cell wall. Strain L1(T) had a temperature optimum of 45 degrees C and the optimum pH for growth was 1.0. Strain L1(T) was capable of chemomixotrophic growth on ferrous iron and yeast extract. Results of fatty acid analysis, DNA-DNA hybridization, G+C content, and analysis based on 16S rRNA gene sequence indicated that strain L1(T) should be grouped in the genus Ferroplasma, and represented a new species, Ferroplasma thermophilum. Ferroplasma thermophilum in combination with Acidithiobacillus caldus and Leptospirillum ferriphilum could improve the copper dissolution in bioleaching of chalcopyrite. A novel extremely acidophilic, moderately thermophilic archaeon isolated from a bioleaching reactor has been identified as F. thermophilum that played an important role in bioleaching of chalcopyrite at low pH. This study contributes to understand the characteristics of F. thermophilum L1(T) and its role in bioleaching of sulfide ores.

Characterization of extreme precipitation within atmospheric river events over California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeon, S.; Prabhat,; Byna, S.

Atmospheric rivers (ARs) are large, spatially coherent weather systems with high concentrations of elevated water vapor. These systems often cause severe downpours and flooding over the western coastal United States – and with the availability of more atmospheric moisture in the future under global warming we expect ARs to play an important role as potential causes of extreme precipitation changes. Therefore, we aim to investigate changes in extreme precipitation properties correlated with AR events in a warmer climate, which are large-scale meteorological patterns affecting the weather and climate of California. We have recently developed the TECA (Toolkit for Extreme Climatemore » Analysis) software for automatically identifying and tracking features in climate data sets. Specifically, we can now identify ARs that make landfall on the western coast of North America. Based on this detection procedure, we can investigate the impact of ARs by exploring the spatial extent of AR precipitation using climate model (CMIP5) simulations and characterize spatial patterns of dependence for future projections between AR precipitation extremes under climate change within the statistical framework. Our results show that AR events in the future RCP (Representative Concentration Pathway)8.5 scenario (2076–2100) tend to produce heavier rainfall with higher frequency and longer days than events from the historical run (1981–2005). We also find that the dependence between extreme precipitation events has a shorter spatial range, within localized areas in California, under the high future emissions scenario than under the historical run.« less

Characterization of extreme precipitation within atmospheric river events over California

DOE PAGES

Jeon, S.; Prabhat,; Byna, S.; ...

2015-11-17

Atmospheric rivers (ARs) are large, spatially coherent weather systems with high concentrations of elevated water vapor. These systems often cause severe downpours and flooding over the western coastal United States – and with the availability of more atmospheric moisture in the future under global warming we expect ARs to play an important role as potential causes of extreme precipitation changes. Therefore, we aim to investigate changes in extreme precipitation properties correlated with AR events in a warmer climate, which are large-scale meteorological patterns affecting the weather and climate of California. We have recently developed the TECA (Toolkit for Extreme Climatemore » Analysis) software for automatically identifying and tracking features in climate data sets. Specifically, we can now identify ARs that make landfall on the western coast of North America. Based on this detection procedure, we can investigate the impact of ARs by exploring the spatial extent of AR precipitation using climate model (CMIP5) simulations and characterize spatial patterns of dependence for future projections between AR precipitation extremes under climate change within the statistical framework. Our results show that AR events in the future RCP (Representative Concentration Pathway)8.5 scenario (2076–2100) tend to produce heavier rainfall with higher frequency and longer days than events from the historical run (1981–2005). We also find that the dependence between extreme precipitation events has a shorter spatial range, within localized areas in California, under the high future emissions scenario than under the historical run.« less

Stabilization of nucleic acids by unusual polyamines produced by an extreme thermophile, Thermus thermophilus

PubMed Central

2005-01-01

Extreme thermophiles produce two types of unusual polyamine: long linear polyamines such as caldopentamine and caldohexamine, and branched polyamines such as quaternary ammonium compounds [e.g. tetrakis(3-aminopropyl)ammonium]. To clarify the physiological roles of long linear and branched polyamines in thermophiles, we synthesized them chemically and tested their effects on the stability of ds (double-stranded) and ss (single-stranded) DNAs and tRNA in response to thermal denaturation, as measured by differential scanning calorimetry. Linear polyamines stabilized dsDNA in proportion to the number of amino nitrogen atoms within their molecular structure. We used the empirical results to derive formulae that estimate the melting temperature of dsDNA in the presence of polyamines of a particular molecular composition. ssDNA and tRNA were stabilized more effectively by tetrakis(3-aminopropyl)ammonium than any of the other polyamines tested. We propose that long linear polyamines are effective to stabilize DNA, and tetrakis(3-aminopropyl)ammonium plays important roles in stabilizing RNAs in thermophile cells. PMID:15673283

Advance directives: survey of primary care patients.

PubMed

O'Sullivan, Rory; Mailo, Kevin; Angeles, Ricardo; Agarwal, Gina

2015-04-01

To establish the prevalence of patients with advance directives in a family practice, and to describe patients' perspectives on a family doctor's role in initiating discussions about advance directives. A self-administered patient questionnaire. A busy urban family medicine teaching clinic in Hamilton, Ont. A convenience sample of adult patients attending the clinic over the course of a typical business week. The prevalence of advance directives in the patient population was determined, and the patients' expectations regarding the role of their family doctors were elucidated. The survey population consisted of 800 participants (a response rate of 72.5%) well distributed across age groups; 19.7% had written advance directives and 43.8% had previously discussed the topic of advance directives, but only 4.3% of these discussions had occurred with family doctors. In 5.7% of cases, a family physician had raised the issue; 72.3% of respondents believed patients should initiate the discussion. Patients who considered advance directives extremely important were significantly more likely to want their family doctors to start the conversation (odds ratio 3.98; P < .05). Advance directives were not routinely addressed in the family practice. Most patients preferred to initiate the discussion of advance directives. However, patients who considered the subject extremely important wanted their family doctors to initiate the discussion. Copyright© the College of Family Physicians of Canada.

Sleep in the Intensive Care Unit

PubMed Central

Friese, Randall S.; Gehlbach, Brian K.; Schwab, Richard J.; Weinhouse, Gerald L.; Jones, Shirley F.

2015-01-01

Sleep is an important physiologic process, and lack of sleep is associated with a host of adverse outcomes. Basic and clinical research has documented the important role circadian rhythm plays in biologic function. Critical illness is a time of extreme vulnerability for patients, and the important role sleep may play in recovery for intensive care unit (ICU) patients is just beginning to be explored. This concise clinical review focuses on the current state of research examining sleep in critical illness. We discuss sleep and circadian rhythm abnormalities that occur in ICU patients and the challenges to measuring alterations in circadian rhythm in critical illness and review methods to measure sleep in the ICU, including polysomnography, actigraphy, and questionnaires. We discuss data on the impact of potentially modifiable disruptors to patient sleep, such as noise, light, and patient care activities, and report on potential methods to improve sleep in the setting of critical illness. Finally, we review the latest literature on sleep disturbances that persist or develop after critical illness. PMID:25594808

The Imprint of Extreme Climate Events in Century-Long Time Series of Wood Anatomical Traits in High-Elevation Conifers

PubMed Central

Carrer, Marco; Brunetti, Michele; Castagneri, Daniele

2016-01-01

Extreme climate events are of key importance for forest ecosystems. However, both the inherent infrequency, stochasticity and multiplicity of extreme climate events, and the array of biological responses, challenges investigations. To cope with the long life cycle of trees and the paucity of the extreme events themselves, our inferences should be based on long-term observations. In this context, tree rings and the related xylem anatomical traits represent promising sources of information, due to the wide time perspective and quality of the information they can provide. Here we test, on two high-elevation conifers (Larix decidua and Picea abies sampled at 2100 m a.s.l. in the Eastern Alps), the associations among temperature extremes during the growing season and xylem anatomical traits, specifically the number of cells per ring (CN), cell wall thickness (CWT), and cell diameter (CD). To better track the effect of extreme events over the growing season, tree rings were partitioned in 10 sectors. Climate variability has been reconstructed, for 1800–2011 at monthly resolution and for 1926–2011 at daily resolution, by exploiting the excellent availability of very long and high quality instrumental records available for the surrounding area, and taking into account the relationship between meteorological variables and site topographical settings. Summer temperature influenced anatomical traits of both species, and tree-ring anatomical profiles resulted as being associated to temperature extremes. Most of the extreme values in anatomical traits occurred with warm (positive extremes) or cold (negative) conditions. However, 0–34% of occurrences did not match a temperature extreme event. Specifically, CWT and CN extremes were more clearly associated to climate than CD, which presented a bias to track cold extremes. Dendroanatomical analysis, coupled to high-quality daily-resolved climate records, seems a promising approach to study the effects of extreme events on trees, but further investigations are needed to improve our comprehension of the critical role of such elusive events in forest ecosystems. PMID:27242880

Changes and Attribution of Extreme Precipitation in Climate Models: Subdaily and Daily Scales

NASA Astrophysics Data System (ADS)

Zhang, W.; Villarini, G.; Scoccimarro, E.; Vecchi, G. A.

2017-12-01

Extreme precipitation events are responsible for numerous hazards, including flooding, soil erosion, and landslides. Because of their significant socio-economic impacts, the attribution and projection of these events is of crucial importance to improve our response, mitigation and adaptation strategies. Here we present results from our ongoing work.In terms of attribution, we use idealized experiments [pre-industrial control experiment (PI) and 1% per year increase (1%CO2) in atmospheric CO2] from ten general circulation models produced under the Coupled Model Intercomparison Project Phase 5 (CMIP5) and the fraction of attributable risk to examine the CO2 effects on extreme precipitation at the sub-daily and daily scales. We find that the increased CO2 concentration substantially increases the odds of the occurrence of sub-daily precipitation extremes compared to the daily scale in most areas of the world, with the exception of some regions in the sub-tropics, likely in relation to the subsidence of the Hadley Cell. These results point to the large role that atmospheric CO2 plays in extreme precipitation under an idealized framework. Furthermore, we investigate the changes in extreme precipitation events with the Community Earth System Model (CESM) climate experiments using the scenarios consistent with the 1.5°C and 2°C temperature targets. We find that the frequency of annual extreme precipitation at a global scale increases in both 1.5°C and 2°C scenarios until around 2070, after which the magnitudes of the trend become much weaker or even negative. Overall, the frequency of global annual extreme precipitation is similar between 1.5°C and 2°C for the period 2006-2035, and the changes in extreme precipitation in individual seasons are consistent with those for the entire year. The frequency of extreme precipitation in the 2°C experiments is higher than for the 1.5°C experiment after the late 2030s, particularly for the period 2071-2100.

Western US high June 2015 temperatures and their relation to global warming and soil moisture

NASA Astrophysics Data System (ADS)

Philip, Sjoukje Y.; Kew, Sarah F.; Hauser, Mathias; Guillod, Benoit P.; Teuling, Adriaan J.; Whan, Kirien; Uhe, Peter; Oldenborgh, Geert Jan van

2018-04-01

The Western US states Washington (WA), Oregon (OR) and California (CA) experienced extremely high temperatures in June 2015. The temperature anomalies were so extreme that they cannot be explained with global warming alone. We investigate the hypothesis that soil moisture played an important role as well. We use a land surface model and a large ensemble from the weather@home modelling effort to investigate the coupling between soil moisture and temperature in a warming world. Both models show that May was anomalously dry, satisfying a prerequisite for the extreme heat wave, and they indicate that WA and OR are in a wet-to-dry transitional soil moisture regime. We use two different land surface-atmosphere coupling metrics to show that there was strong coupling between temperature, latent heat flux and the effect of soil moisture deficits on the energy balance in June 2015 in WA and OR. June temperature anomalies conditioned on wet/dry conditions show that both the mean and extreme temperatures become hotter for dry soils, especially in WA and OR. Fitting a Gaussian model to temperatures using soil moisture as a covariate shows that the June 2015 temperature values fit well in the extrapolated empirical temperature/drought lines. The high temperature anomalies in WA and OR are thus to be expected, given the dry soil moisture conditions and that those regions are in the transition from a wet to a dry regime. CA is already in the dry regime and therefore the necessity of taking soil moisture into account is of lower importance.

Stresses associated with career success for women.

PubMed

Whitfield, M D

1978-02-01

In recent years, more women have pursued careers in business and the traditionally male professions. Those that have succeeded live with a high degree of environmental stress. Since some of them are now consulting psychiatrists it is important that the psychiatrist be able to differentiate difficulties which have a cultural basis from those stemming from individual psychodynamics. Cultural stresses have been reviewed under three headings: inaccurate stereotypes; inadequate cultural supports; and role overload. It has been suggested that contact with her peer group is extremely important for this type of woman patient. The peer group provides both support and a frame of reference within which individual problems may be understood.

Accurately Characterizing the Importance of Wave-Particle Interactions in Radiation Belt Dynamics: The Pitfalls of Statistical Wave Representations

NASA Technical Reports Server (NTRS)

Murphy, Kyle R.; Mann, Ian R.; Rae, I. Jonathan; Sibeck, David G.; Watt, Clare E. J.

2016-01-01

Wave-particle interactions play a crucial role in energetic particle dynamics in the Earths radiation belts. However, the relative importance of different wave modes in these dynamics is poorly understood. Typically, this is assessed during geomagnetic storms using statistically averaged empirical wave models as a function of geomagnetic activity in advanced radiation belt simulations. However, statistical averages poorly characterize extreme events such as geomagnetic storms in that storm-time ultralow frequency wave power is typically larger than that derived over a solar cycle and Kp is a poor proxy for storm-time wave power.

Role of the podiatrist in diabetic limb salvage.

PubMed

Kim, Paul J; Attinger, Christopher E; Evans, Karen K; Steinberg, John S

2012-10-01

Podiatrists play an important role in the multidisciplinary team in diabetic limb salvage. Podiatry is a specialty that is licensed in the diagnoses and treatment of pathologies of the foot and ankle. The treatment includes both conservative and surgical modalities. Understanding the biomechanics of the lower extremity is principally emphasized in the education and training of a podiatrist. This is particularly important in the context of the diabetic foot where biomechanical abnormalities often precede ulcer development. Preventive ulcer development strategies employed by a podiatrist include regular monitoring, routine care of calluses, and insert/shoe recommendations. Further, clinic-based ulcer care as well as surgery that include prophylactic and acute intervention can translate to the preservation of a functional limb. Finally, continuous podiatric management can prevent ulcer recurrence through offloading strategies and diabetic foot education. Copyright © 2012 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

The role of interactions along the flood process chain and implications for risk assessment

NASA Astrophysics Data System (ADS)

Vorogushyn, Sergiy; Apel, Heiko; Viet Nguyen, Dung; Guse, Björn; Kreibich, Heidi; Lüdtke, Stefan; Schröter, Kai; Merz, Bruno

2017-04-01

Floods with their manifold characteristics are shaped by various processes along the flood process chain - from triggering meteorological extremes through catchment and river network process down to impacts on societies. In flood risk systems numerous interactions and feedbacks along the process chain may occur which finally shape spatio-temporal flood patterns and determine the ultimate risk. In this talk, we review some important interactions in the atmosphere-catchment, river-dike-floodplain and vulnerability compartments of the flood risk system. We highlight the importance of spatial interactions for flood hazard and risk assessment. For instance, the role of spatial rainfall structure or wave superposition in river networks is elucidated with selected case studies. In conclusion, we show the limits of current methods in assessment of large-scale flooding and outline the approach to more comprehensive risk assessment based on our regional flood risk model (RFM) for Germany.

The Fate and Impact of Internal Waves in Nearshore Ecosystems

NASA Astrophysics Data System (ADS)

Woodson, C. B.

2018-01-01

Internal waves are widespread features of global oceans that play critical roles in mixing and thermohaline circulation. Similarly to surface waves, internal waves can travel long distances, ultimately breaking along continental margins. These breaking waves can transport deep ocean water and associated constituents (nutrients, larvae, and acidic low-oxygen waters) onto the shelf and locally enhance turbulence and mixing, with important effects on nearshore ecosystems. We are only beginning to understand the role internal waves play in shaping nearshore ecosystems. Here, I review the physics of internal waves in shallow waters and identify two commonalities among internal waves in the nearshore: exposure to deep offshore waters and enhanced turbulence and mixing. I relate these phenomena to important ecosystem processes ranging from extreme events to fertilization success to draw general conclusions about the influence of internal waves on ecosystems and the effects of internal waves in a changing climate.

The Fate and Impact of Internal Waves in Nearshore Ecosystems.

PubMed

Woodson, C B

2018-01-03

Internal waves are widespread features of global oceans that play critical roles in mixing and thermohaline circulation. Similarly to surface waves, internal waves can travel long distances, ultimately breaking along continental margins. These breaking waves can transport deep ocean water and associated constituents (nutrients, larvae, and acidic low-oxygen waters) onto the shelf and locally enhance turbulence and mixing, with important effects on nearshore ecosystems. We are only beginning to understand the role internal waves play in shaping nearshore ecosystems. Here, I review the physics of internal waves in shallow waters and identify two commonalities among internal waves in the nearshore: exposure to deep offshore waters and enhanced turbulence and mixing. I relate these phenomena to important ecosystem processes ranging from extreme events to fertilization success to draw general conclusions about the influence of internal waves on ecosystems and the effects of internal waves in a changing climate.

Bias correction method for climate change impact assessment at a basin scale

NASA Astrophysics Data System (ADS)

Nyunt, C.; Jaranilla-sanchez, P. A.; Yamamoto, A.; Nemoto, T.; Kitsuregawa, M.; Koike, T.

2012-12-01

Climate change impact studies are mainly based on the general circulation models GCM and these studies play an important role to define suitable adaptation strategies for resilient environment in a basin scale management. For this purpose, this study summarized how to select appropriate GCM to decrease the certain uncertainty amount in analysis. This was applied to the Pampanga, Angat and Kaliwa rivers in Luzon Island, the main island of Philippine and these three river basins play important roles in irrigation water supply, municipal water source for Metro Manila. According to the GCM scores of both seasonal evolution of Asia summer monsoon and spatial correlation and root mean squared error of atmospheric variables over the region, finally six GCM is chosen. Next, we develop a complete, efficient and comprehensive statistical bias correction scheme covering extremes events, normal rainfall and frequency of dry period. Due to the coarse resolution and parameterization scheme of GCM, extreme rainfall underestimation, too many rain days with low intensity and poor representation of local seasonality have been known as bias of GCM. Extreme rainfall has unusual characteristics and it should be focused specifically. Estimated maximum extreme rainfall is crucial for planning and design of infrastructures in river basin. Developing countries have limited technical, financial and management resources for implementing adaptation measures and they need detailed information of drought and flood for near future. Traditionally, the analysis of extreme has been examined using annual maximum series (AMS) adjusted to a Gumbel or Lognormal distribution. The drawback is the loss of the second, third etc, largest rainfall. Another approach is partial duration series (PDS) constructed using the values above a selected threshold and permit more than one event per year. The generalized Pareto distribution (GPD) has been used to model PDS and it is the series of excess over a threshold. In this study, the lowest value of AMS of observed is selected as threshold and simultaneously same frequency is considered as extremes in corresponding GCM gridded series. After fitting to GP distribution, bias corrected GCM extreme is found by using the inverse function of observed extremes. The results show it can remove bias effectively. For projected climate, the same transfer function between historical observed and GCM was applied. Moreover, frequency analysis of maximum extreme intensity estimation was done for validation and then approximate for near future by using identical function as past. To fix the error in the number of no rain days of GCM, ranking order statistics is used and define in GCM same as the frequency of wet days in observed station. After this rank, GCM output will be zero and identify same threshold for future projection. Normal rainfall is classified as between threshold of extreme and no rain day. We assume monthly normal rainfall follow gamma distribution. Then, we mapped the CDF of GCM normal rainfall to station's one in each month and bias corrected rainfall is available. In summary, bias of GCM have been addressed efficiently and validated at point scale by seasonal climatology and at all stations for evaluating downscaled rainfall performance. The results show bias corrected and downscaled scheme is good enough for climate impact study.

On the Role of SST Forcing in the 2011 and 2012 Extreme U.S. Heat and Drought: A Study in Contrasts

NASA Technical Reports Server (NTRS)

Wang, Hailan; Schubert, Siegfried; Koster, Randal; Ham, Yoo-Geun; Suarez, Max

2013-01-01

This study compares the extreme heat and drought that developed over the United States in 2011 and 2012 with a focus on the role of SST forcing. Experiments with the NASA GEOS-5 atmospheric general circulation model show that the winter/spring response over the U.S. to the Pacific SST is remarkably similar for the two years despite substantial differences in the tropical Pacific SST. As such, the pronounced winter and early spring temperature differences between the two years (warmth confined to the south in 2011 and covering much of the continent in 2012) primarily reflect differences in the contributions from the Atlantic and Indian Oceans, with both acting to cool the east and upper mid-west during 2011, while during 2012 the Indian Ocean reinforced the Pacific-driven continental-wide warming and the Atlantic played a less important role. During late spring and summer of 2011 the tropical Pacific SST force a continued warming and drying over the southern U.S., though considerably weaker than observed. Nevertheless, the observed anomalies fall within the models intra-ensemble spread. In contrast, the rapid development of intense heat and drying over the central U.S. during June and July of 2012 falls outside the models intra-ensemble spread. The response to the SST (a northward expansion of a modest summer warming linked to the Atlantic) gives little indication that 2012 would produce record-breaking precipitation deficits and heat in the central Great Plains. A diagnosis of the 2012 observed circulation anomalies shows that the most extreme heat and drought was tied to the development of a stationary Rossby wave and an associated anomalous upper tropospheric high maintained by weather transients.

Reflections

NASA Astrophysics Data System (ADS)

Greiner, Walter

2012-01-01

This symposium was very special. It was topical: Some of the most outstanding problems in Nuclear Physics were discussed: Superheavy elements; extremely neutron rich elements, as well as nuclei with strangeness and their possible creation in the cosmos and on earth; the nuclear equation of state has to be identified within strongly compressed and hot nuclear matter as it appears in nucleus-nucleus encounters; giant nuclear systems which are short lived (˜ 10-19 - 10-20 seconds) and extremely important for identifying the vacuum decay in overcritical electric fields (this is a very fundamental process - the most fundamental one in Quantum Electrodynamics!); astrophysical centers of extreme high density around which magnificent sun-like objects are Kepler-orbiting are discovered in our Galaxy by R. Genzel and colleagues (these centers are no black holes those don't exist at all because repulsive gravitational forces may play an important role - the pseudocomplex general relativity eliminates the Schwarzschild singularity); network physics for distributing energy (nuclear, wind, sun, tides,...) all over Europe (and over the world) is basic for energy consumption now and even more so in future. We heard wonderful talks and I am grateful to all the friends and speakers (from Russia, America, Europe and India) for coming to Goa. It was a great symposium! Particular thanks go to Professor Bikash Sinha and especially to Professor Debades Bandyopadhyay from Calcutta who had the idea for and organized this Goa-symposium....

Automatic delineation and 3D visualization of the human ventricular system using probabilistic neural networks

NASA Astrophysics Data System (ADS)

Hatfield, Fraser N.; Dehmeshki, Jamshid

1998-09-01

Neurosurgery is an extremely specialized area of medical practice, requiring many years of training. It has been suggested that virtual reality models of the complex structures within the brain may aid in the training of neurosurgeons as well as playing an important role in the preparation for surgery. This paper focuses on the application of a probabilistic neural network to the automatic segmentation of the ventricles from magnetic resonance images of the brain, and their three dimensional visualization.

Bone scanning in the adductor insertion avulsion syndrome.

PubMed

Mahajan, Madhuri Shimpi

2013-05-01

A thigh splint (adductor insertion avulsion syndrome) is a relatively uncommon diagnosis analogous to shin splints. This article reports a 19-year-old female patient NOT a regular athlete who presented with groin pain. Physical examination was non-specific; magnetic resonance imaging pelvis did not reveal any abnormality. Patient referred for whole body bone scan, especially to locate any abnormality in the spine. This study highlights the role of whole body bone scan in the evaluation of groin pain and importance of evaluation of whole lower extremity.

BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".

PubMed

Chen, Deliang; Savidge, Tor

2015-08-28

Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field-dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis. Copyright © 2015, American Association for the Advancement of Science.

EEG and Coma.

PubMed

Ardeshna, Nikesh I

2016-03-01

Coma is defined as a state of extreme unresponsiveness, in which a person exhibits no voluntary movement or behavior even to painful stimuli. The utilization of EEG for patients in coma has increased dramatically over the last few years. In fact, many institutions have set protocols for continuous EEG (cEEG) monitoring for patients in coma due to potential causes such as subarachnoid hemorrhage or cardiac arrest. Consequently, EEG plays an important role in diagnosis, managenent, and in some cases even prognosis of coma patients.

The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential.

PubMed

Adekoya, Olayiwola A; Sylte, Ingebrigt

2009-01-01

Zinc containing peptidases are widely distributed in nature and have important roles in many physiological processes. M4 family comprises numerous zinc-dependent metallopeptidases that hydrolyze peptide bonds. A large number of these enzymes are implicated as virulence factors of the microorganisms that produce them and are therefore potential drug targets. Some enzymes of the family are able to function at the extremes of temperatures, and some function in organic solvents. Thereby enzymes of the thermolysin family have an innovative potential for biotechnological applications.

[Role of multislice computed tomography in the diagnosis of acute rupture of the thoracic aorta and hepatic artery in a patient with severe concomitant injury].

PubMed

Muslimov, R Sh; Sharifullin, F A; Chernaia, N R; Novruzbekov, M S; Kokov, L S

2015-01-01

Acute traumatic aortic rupture is associated with extremely high mortality rates and requires emergency diagnosis and treatment. This clinical example shows the role of multislice spiral computed tomography in the emergency diagnosis of rupture of two large arterial vessels in severe concomitant injury. It presents the benefits of this rapid and noninvasive imaging technique, an algorithm of the study and the semiotics of injuries in patients with suspected traumatic aortic rupture. The paper also shows the importance of this method in defining treatment policy and then in the assessment of the results of the performed correction.

Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.

PubMed

Akiyama, Koichi; Iwaki, Tomoko; Sugimoto, Naoko; Chardwiriyapreecha, Soracom; Kawano, Miyuki; Nishimoto, Sogo; Sugahara, Takuya; Sekito, Takayuki; Kakinuma, Yoshimi

2011-01-01

ATP-binding cassette (ABC) transporter plays an important role for resistance against xenobiotics. There are eleven ABC transporter genes in the genome of fission yeast Schizosaccharomyces pombe. We examined the role of ABC transporter against the toxicity of tributyltin chloride (TBT), a widespread environmental pollutant, in cell growth. Among individual ABC transporter mutants, the growth of a mutant deficient in Bfr1p, a plasma membrane-embedded transporter, was extremely sensitive to TBT. The lethal TBT concentration inducing 50% of cell death (LC(50)) was 25 µM for the parent strain and 10.2 µM for the bfr1∆ mutant. Thus, Bfr1p was responsible for TBT resistance in S. pombe.

Planckian charged black holes in ultraviolet self-complete quantum gravity

NASA Astrophysics Data System (ADS)

Nicolini, Piero

2018-03-01

We present an analysis of the role of the charge within the self-complete quantum gravity paradigm. By studying the classicalization of generic ultraviolet improved charged black hole solutions around the Planck scale, we showed that the charge introduces important differences with respect to the neutral case. First, there exists a family of black hole parameters fulfilling the particle-black hole condition. Second, there is no extremal particle-black hole solution but quasi extremal charged particle-black holes at the best. We showed that the Hawking emission disrupts the condition of particle-black hole. By analyzing the Schwinger pair production mechanism, the charge is quickly shed and the particle-black hole condition can ultimately be restored in a cooling down phase towards a zero temperature configuration, provided non-classical effects are taken into account.

Interpreting the Climatic Effects on Xylem Functional Traits in Two Mediterranean Oak Species: The Role of Extreme Climatic Events.

PubMed

Rita, Angelo; Borghetti, Marco; Todaro, Luigi; Saracino, Antonio

2016-01-01

In the Mediterranean region, the widely predicted rise in temperature, change in the precipitation pattern, and increase in the frequency of extreme climatic events are expected to alter the shape of ecological communities and to affect plant physiological processes that regulate ecosystem functioning. Although change in the mean values are important, there is increasing evidence that plant distribution, survival, and productivity respond to extremes rather than to the average climatic condition. The present study aims to assess the effects of both mean and extreme climatic conditions on radial growth and functional anatomical traits using long-term tree-ring time series of two co-existing Quercus spp. from a drought-prone site in Southern Italy. In particular, this is the first attempt to apply the Generalized Additive Model for Location, Scale, and Shape (GAMLSS) technique and Bayesian modeling procedures to xylem traits data set, with the aim of (i) detecting non-linear long-term responses to climate and (ii) exploring relationships between climate extreme and xylem traits variability in terms of probability of occurrence. This study demonstrates the usefulness of long-term xylem trait chronologies as records of environmental conditions at annual resolution. Statistical analyses revealed that most of the variability in tree-ring width and specific hydraulic conductivity might be explained by cambial age. Additionally, results highlighted appreciable relationships between xylem traits and climate variability more than tree-ring width, supporting also the evidence that the plant hydraulic traits are closely linked to local climate extremes rather than average climatic conditions. We reported that the probability of extreme departure in specific hydraulic conductivity (Ks) rises at extreme values of Standardized Precipitation Index (SPI). Therefore, changing frequency or intensity of extreme events might overcome the adaptive limits of vascular transport, resulting in substantial reduction of hydraulic functionality and, hence increased incidence of xylem dysfunctions.

Interpreting the Climatic Effects on Xylem Functional Traits in Two Mediterranean Oak Species: The Role of Extreme Climatic Events

PubMed Central

Rita, Angelo; Borghetti, Marco; Todaro, Luigi; Saracino, Antonio

2016-01-01

In the Mediterranean region, the widely predicted rise in temperature, change in the precipitation pattern, and increase in the frequency of extreme climatic events are expected to alter the shape of ecological communities and to affect plant physiological processes that regulate ecosystem functioning. Although change in the mean values are important, there is increasing evidence that plant distribution, survival, and productivity respond to extremes rather than to the average climatic condition. The present study aims to assess the effects of both mean and extreme climatic conditions on radial growth and functional anatomical traits using long-term tree-ring time series of two co-existing Quercus spp. from a drought-prone site in Southern Italy. In particular, this is the first attempt to apply the Generalized Additive Model for Location, Scale, and Shape (GAMLSS) technique and Bayesian modeling procedures to xylem traits data set, with the aim of (i) detecting non-linear long-term responses to climate and (ii) exploring relationships between climate extreme and xylem traits variability in terms of probability of occurrence. This study demonstrates the usefulness of long-term xylem trait chronologies as records of environmental conditions at annual resolution. Statistical analyses revealed that most of the variability in tree-ring width and specific hydraulic conductivity might be explained by cambial age. Additionally, results highlighted appreciable relationships between xylem traits and climate variability more than tree-ring width, supporting also the evidence that the plant hydraulic traits are closely linked to local climate extremes rather than average climatic conditions. We reported that the probability of extreme departure in specific hydraulic conductivity (Ks) rises at extreme values of Standardized Precipitation Index (SPI). Therefore, changing frequency or intensity of extreme events might overcome the adaptive limits of vascular transport, resulting in substantial reduction of hydraulic functionality and, hence increased incidence of xylem dysfunctions. PMID:27532008

Environmental risk assessment of Polish wastewater treatment plant activity.

PubMed

Kudłak, Błażej; Wieczerzak, Monika; Yotova, Galina; Tsakovski, Stefan; Simeonov, Vasil; Namieśnik, Jacek

2016-10-01

Wastewater treatment plants (WWTPs) play an extremely important role in shaping modern society's environmental well-being and awareness, however only well operated and supervised systems can be considered as environmentally sustainable. For this reason, an attempt was undertaken to assess the environmental burden posed by WWTPs in major Polish cities by collecting water samples prior to and just after wastewater release points. Both classical and biological methods (Microtox(®), Ostracodtoxkit F™ and comet assay) were utilized to assess environmental impact of given WWTP. Interestingly, in some cases, water quality improvement indicated as a toxicity decrement toward one of the bio-indicating organisms makes water worse for others in the systems. This fact is particularly noticeable in case of Silesian cities where heavy industry and high population density is present. It proves that WWTP should undergo individual evaluation of pollutant removal efficiency and tuned to selectively remove pollutants of highest risk to surrounding regional ecosystems. Biotests again proved to be an extremely important tool to fully assess the impact of environmental stressors on water bodies receiving effluents from WWTPs. Copyright © 2016 Elsevier Ltd. All rights reserved.

Major cause of unprecedented Arctic warming in January 2016: Critical role of an Atlantic windstorm

PubMed Central

Kim, Baek-Min; Hong, Ja-Young; Jun, Sang-Yoon; Zhang, Xiangdong; Kwon, Hataek; Kim, Seong-Joong; Kim, Joo-Hong; Kim, Sang-Woo; Kim, Hyun-Kyung

2017-01-01

In January 2016, the Arctic experienced an extremely anomalous warming event after an extraordinary increase in air temperature at the end of 2015. During this event, a strong intrusion of warm and moist air and an increase in downward longwave radiation, as well as a loss of sea ice in the Barents and Kara seas, were observed. Observational analyses revealed that the abrupt warming was triggered by the entry of a strong Atlantic windstorm into the Arctic in late December 2015, which brought enormous moist and warm air masses to the Arctic. Although the storm terminated at the eastern coast of Greenland in late December, it was followed by a prolonged blocking period in early 2016 that sustained the extreme Arctic warming. Numerical experiments indicate that the warming effect of sea ice loss and associated upward turbulent heat fluxes are relatively minor in this event. This result suggests the importance of the synoptically driven warm and moist air intrusion into the Arctic as a primary contributing factor of this extreme Arctic warming event. PMID:28051170

Overview of Key Results from SDO Extreme ultraviolet Variability Experiment (EVE)

NASA Astrophysics Data System (ADS)

Woods, Tom; Eparvier, Frank; Jones, Andrew; Mason, James; Didkovsky, Leonid; Chamberlin, Phil

2016-10-01

The SDO Extreme ultraviolet Variability Experiment (EVE) includes several channels to observe the solar extreme ultraviolet (EUV) spectral irradiance from 1 to 106 nm. These channels include the Multiple EUV Grating Spectrograph (MEGS) A, B, and P channels from the University of Colorado (CU) and the EUV SpectroPhometer (ESP) channels from the University of Southern California (USC). The solar EUV spectrum is rich in many different emission lines from the corona, transition region, and chromosphere. The EVE full-disk irradiance spectra are important for studying the solar impacts in Earth's ionosphere and thermosphere and are useful for space weather operations. In addition, the EVE observations, with its high spectral resolution of 0.1 nm and in collaboration with AIA solar EUV images, have proven valuable for studying active region evolution and explosive energy release during flares and coronal eruptions. These SDO measurements have revealed interesting results such as understanding the flare variability over all wavelengths, discovering and classifying different flare phases, using coronal dimming measurements to predict CME properties of mass and velocity, and exploring the role of nano-flares in continual heating of active regions.

Neighbourhood green space, physical function and participation in physical activities among elderly men: the Caerphilly Prospective study

PubMed Central

2014-01-01

Background The built environment in which older people live plays an important role in promoting or inhibiting physical activity. Most work on this complex relationship between physical activity and the environment has excluded people with reduced physical function or ignored the difference between groups with different levels of physical function. This study aims to explore the role of neighbourhood green space in determining levels of participation in physical activity among elderly men with different levels of lower extremity physical function. Method Using data collected from the Caerphilly Prospective Study (CaPS) and green space data collected from high resolution Landmap true colour aerial photography, we first investigated the effect of the quantity of neighbourhood green space and the variation in neighbourhood vegetation on participation in physical activity for 1,010 men aged 66 and over in Caerphilly county borough, Wales, UK. Second, we explored whether neighbourhood green space affects groups with different levels of lower extremity physical function in different ways. Results Increasing percentage of green space within a 400 meters radius buffer around the home was significantly associated with more participation in physical activity after adjusting for lower extremity physical function, psychological distress, general health, car ownership, age group, marital status, social class, education level and other environmental factors (OR = 1.21, 95% CI 1.05, 1.41). A statistically significant interaction between the variation in neighbourhood vegetation and lower extremity physical function was observed (OR = 1.92, 95% CI 1.12, 3.28). Conclusion Elderly men living in neighbourhoods with more green space have higher levels of participation in regular physical activity. The association between variation in neighbourhood vegetation and regular physical activity varied according to lower extremity physical function. Subjects reporting poor lower extremity physical function living in neighbourhoods with more homogeneous vegetation (i.e. low variation) were more likely to participate in regular physical activity than those living in neighbourhoods with less homogeneous vegetation (i.e. high variation). Good lower extremity physical function reduced the adverse effect of high variation vegetation on participation in regular physical activity. This provides a basis for the future development of novel interventions that aim to increase levels of physical activity in later life, and has implications for planning policy to design, preserve, facilitate and encourage the use of green space near home. PMID:24646136

Neighbourhood green space, physical function and participation in physical activities among elderly men: the Caerphilly Prospective study.

PubMed

Gong, Yi; Gallacher, John; Palmer, Stephen; Fone, David

2014-03-19

The built environment in which older people live plays an important role in promoting or inhibiting physical activity. Most work on this complex relationship between physical activity and the environment has excluded people with reduced physical function or ignored the difference between groups with different levels of physical function. This study aims to explore the role of neighbourhood green space in determining levels of participation in physical activity among elderly men with different levels of lower extremity physical function. Using data collected from the Caerphilly Prospective Study (CaPS) and green space data collected from high resolution Landmap true colour aerial photography, we first investigated the effect of the quantity of neighbourhood green space and the variation in neighbourhood vegetation on participation in physical activity for 1,010 men aged 66 and over in Caerphilly county borough, Wales, UK. Second, we explored whether neighbourhood green space affects groups with different levels of lower extremity physical function in different ways. Increasing percentage of green space within a 400 meters radius buffer around the home was significantly associated with more participation in physical activity after adjusting for lower extremity physical function, psychological distress, general health, car ownership, age group, marital status, social class, education level and other environmental factors (OR = 1.21, 95% CI 1.05, 1.41). A statistically significant interaction between the variation in neighbourhood vegetation and lower extremity physical function was observed (OR = 1.92, 95% CI 1.12, 3.28). Elderly men living in neighbourhoods with more green space have higher levels of participation in regular physical activity. The association between variation in neighbourhood vegetation and regular physical activity varied according to lower extremity physical function. Subjects reporting poor lower extremity physical function living in neighbourhoods with more homogeneous vegetation (i.e. low variation) were more likely to participate in regular physical activity than those living in neighbourhoods with less homogeneous vegetation (i.e. high variation). Good lower extremity physical function reduced the adverse effect of high variation vegetation on participation in regular physical activity. This provides a basis for the future development of novel interventions that aim to increase levels of physical activity in later life, and has implications for planning policy to design, preserve, facilitate and encourage the use of green space near home.

Symbiont community stability through severe coral bleaching in a thermally extreme lagoon.

PubMed

Smith, E G; Vaughan, G O; Ketchum, R N; McParland, D; Burt, J A

2017-05-25

Coral reefs are threatened by climate change as coral-algal symbioses are currently living close to their upper thermal limits. The resilience of the algal partner plays a key role in determining the thermal tolerance of the coral holobiont and therefore, understanding the acclimatory limits of present day coral-algal symbioses is fundamental to forecasting corals' responses to climate change. This study characterised the symbiont community in a highly variable and thermally extreme (Max = 37.5 °C, Min = 16.8 °C) lagoon located in the southern Persian/Arabian Gulf using next generation sequencing of ITS2 amplicons. Despite experiencing extreme temperatures, severe bleaching and many factors that would be expected to promote the presence of, or transition to clade D dominance, the symbiont communities of the lagoon remain dominated by the C3 variant, Symbiodinium thermophilum. The stability of this symbiosis across multiple genera with different means of symbiont transmission highlights the importance of Symbiodinium thermophilum for corals living at the acclimatory limits of modern day corals. Corals in this extreme environment did not undergo adaptive bleaching, suggesting they are living at the edge of their acclimatory potential and that this valuable source of thermally tolerant genotypes may be lost in the near future under climate change.

A narrative insight into disability pensioners' work experiences in highly gender-segregated occupations.

PubMed

Reinholdt, Sofia; Alexanderson, Kristina

2009-01-01

This study examined some plausible explanations for the higher rates of ill-health seen in extremely gender-segregated occupations. The focus was on the work experiences of disability pensioners with last jobs prior to pensioning characterized by segregated conditions (i.e., less than 10% of the employees of their own sex). Seven interviews were subjected to qualitative content analyses focusing on aspects of health selection, gender differences in work tasks, and in the work situation. The results show a negative health selection into occupations in which the participants constitute an extreme minority. There were some differences in work tasks between the gender in extreme minority and the other gender. Exposure to different stress factors related to the minority status included increased visibility, performance pressure, and harassment. Gender had been of main importance for differences in exposure, for assigning work tasks, and for interaction dynamics between the groups in majority and extreme minority. A combination of negative health selection, gender marking of work tasks, and group interaction dynamics related to group proportions and gender may play a role in cumulative health risks. Additional longitudinal studies are needed to identify mechanisms and interactions in this context in order to better understand possible relationships between occupational gender segregation and increased health risks.

Statistical Modeling of Extreme Values and Evidence of Presence of Dragon King (DK) in Solar Wind

NASA Astrophysics Data System (ADS)

Gomes, T.; Ramos, F.; Rempel, E. L.; Silva, S.; C-L Chian, A.

2017-12-01

The solar wind constitutes a nonlinear dynamical system, presenting intermittent turbulence, multifractality and chaotic dynamics. One characteristic shared by many such complex systems is the presence of extreme events, that play an important role in several Geophysical phenomena and their statistical characterization is a problem of great practical relevance. This work investigates the presence of extreme events in time series of the modulus of the interplanetary magnetic field measured by Cluster spacecraft on February 2, 2002. One of the main results is that the solar wind near the Earth's bow shock can be modeled by the Generalized Pareto (GP) and Generalized Extreme Values (GEV) distributions. Both models present a statistically significant positive shape parameter which implyies a heavy tail in the probability distribution functions and an unbounded growth in return values as return periods become too long. There is evidence that current sheets are the main responsible for positive values of the shape parameter. It is also shown that magnetic reconnection at the interface between two interplanetary magnetic flux ropes in the solar wind can be considered as Dragon Kings (DK), a class of extreme events whose formation mechanisms are fundamentally different from others. As long as magnetic reconnection can be classified as a Dragon King, there is the possibility of its identification and even its prediction. Dragon kings had previously been identified in time series of financial crashes, nuclear power generation accidents, stock market and so on. It is believed that they are associated with the occurrence of extreme events in dynamical systems at phase transition, bifurcation, crises or tipping points.

Evaluation of WRF-based convection-permitting multi-physics ensemble forecasts over China for an extreme rainfall event on 21 July 2012 in Beijing

NASA Astrophysics Data System (ADS)

Zhu, Kefeng; Xue, Ming

2016-11-01

On 21 July 2012, an extreme rainfall event that recorded a maximum rainfall amount over 24 hours of 460 mm, occurred in Beijing, China. Most operational models failed to predict such an extreme amount. In this study, a convective-permitting ensemble forecast system (CEFS), at 4-km grid spacing, covering the entire mainland of China, is applied to this extreme rainfall case. CEFS consists of 22 members and uses multiple physics parameterizations. For the event, the predicted maximum is 415 mm d-1 in the probability-matched ensemble mean. The predicted high-probability heavy rain region is located in southwest Beijing, as was observed. Ensemble-based verification scores are then investigated. For a small verification domain covering Beijing and its surrounding areas, the precipitation rank histogram of CEFS is much flatter than that of a reference global ensemble. CEFS has a lower (higher) Brier score and a higher resolution than the global ensemble for precipitation, indicating more reliable probabilistic forecasting by CEFS. Additionally, forecasts of different ensemble members are compared and discussed. Most of the extreme rainfall comes from convection in the warm sector east of an approaching cold front. A few members of CEFS successfully reproduce such precipitation, and orographic lift of highly moist low-level flows with a significantly southeasterly component is suggested to have played important roles in producing the initial convection. Comparisons between good and bad forecast members indicate a strong sensitivity of the extreme rainfall to the mesoscale environmental conditions, and, to less of an extent, the model physics.

Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release.

PubMed

Guilfoyle, Amy P; Deshpande, Chandrika N; Schenk, Gerhard; Maher, Megan J; Jormakka, Mika

2014-12-12

GDP release from GTPases is usually extremely slow and is in general assisted by external factors, such as association with guanine exchange factors or membrane-embedded GPCRs (G protein-coupled receptors), which accelerate the release of GDP by several orders of magnitude. Intrinsic factors can also play a significant role; a single amino acid substitution in one of the guanine nucleotide recognition motifs, G5, results in a drastically altered GDP release rate, indicating that the sequence composition of this motif plays an important role in spontaneous GDP release. In the present study, we used the GTPase domain from EcNFeoB (Escherichia coli FeoB) as a model and applied biochemical and structural approaches to evaluate the role of all the individual residues in the G5 loop. Our study confirms that several of the residues in the G5 motif have an important role in the intrinsic affinity and release of GDP. In particular, a T151A mutant (third residue of the G5 loop) leads to a reduced nucleotide affinity and provokes a drastically accelerated dissociation of GDP.

The role of the tropical West Pacific in the extreme northern hemisphere winter of 2013/14

NASA Astrophysics Data System (ADS)

Watson, Peter; Weisheimer, Antje; Knight, Jeff; Palmer, Tim

2016-04-01

In the 2013/14 winter, the eastern USA was exceptionally cold, the Bering Strait region was exceptionally warm, California was in the midst of drought and the UK suffered severe flooding. It has been suggested that elevated SSTs in the tropical West Pacific (TWPAC) were partly to blame due to their producing a Rossby wavetrain that propagated into the extratropics. We find that seasonal forecasts with the tropical atmosphere relaxed towards a reanalysis give 2013/14 winter-mean anomalies with strong similarities to those observed in the Northern Hemisphere, indicating that low-latitude anomalies had a role in the development of the extremes. Relaxing just the TWPAC produces a strong wavetrain over the North Pacific and North America in January, but not in the winter-mean. This suggests that anomalies in this region alone had a large influence, but cannot explain the extremes through the whole winter. We also examine the response to applying the observed TWPAC SST anomalies in two atmospheric general circulation models. We find that this does produce winter-mean anomalies in the North Pacific and North America resembling those observed, but that the tropical forcing of Rossby waves due to the applied SST anomalies appears stronger than that in reanalysis, except in January. Therefore both experiments indicate that the TWPAC influence was important, but the true strength of the TWPAC influence is uncertain. None of the experiments indicate a strong systematic impact of the TWPAC anomalies on Europe.

The role of strigolactones and ethylene in disease caused by Pythium irregulare.

PubMed

Blake, Sara N; Barry, Karen M; Gill, Warwick M; Reid, James B; Foo, Eloise

2016-06-01

Plant hormones play key roles in defence against pathogen attack. Recent work has begun to extend this role to encompass not just the traditional disease/stress hormones, such as ethylene, but also growth-promoting hormones. Strigolactones (SLs) are the most recently defined group of plant hormones with important roles in plant-microbe interactions, as well as aspects of plant growth and development, although the knowledge of their role in plant-pathogen interactions is extremely limited. The oomycete Pythium irregulare is a poorly controlled pathogen of many crops. Previous work has indicated an important role for ethylene in defence against this oomycete. We examined the role of ethylene and SLs in response to this pathogen in pea (Pisum sativum L.) at the molecular and whole-plant levels using a set of well-characterized hormone mutants, including an ethylene-insensitive ein2 mutant and SL-deficient and insensitive mutants. We identified a key role for ethylene signalling in specific cell types that reduces pathogen invasion, extending the work carried out in other species. However, we found no evidence that SL biosynthesis or response influences the interaction of pea with P. irregulare or that synthetic SL influences the growth or hyphal branching of the oomycete in vitro. Future work should seek to extend our understanding of the role of SLs in other plant interactions, including with other fungal, bacterial and viral pathogens, nematodes and insect pests. © 2015 BSPP AND JOHN WILEY & SONS LTD.

Is testosterone important in LUT function in men and women? ICI-RS 2015.

PubMed

Badawi, Jasmin Katrin; Bosch, Ruud; Djurhuus, Jens Christian; Hanna-Mitchell, Ann T

2017-04-01

This review article is a collaborative report based upon the Authors' presentations and Group discussion on the role of testosterone (T) in the male and female lower urinary tract (LUT) which took place at the 6th International Consultation on Incontinence Research Society's (ICI-RS) annual meeting, in Bristol, UK (September 8-10, 2015). It comprises overviews and opinions on both the current state of knowledge of the role of T in LUT function and dysfunction in both sexes. Results from animal studies suggest that T treatment may be beneficial for disorders of the LUT in women including urinary incontinence and pelvic organ prolapse. The need for clinical studies to evaluate the effect of T treatment in peri- and post-menopausal women, taking into account the type of applied androgen, the application form, timing and dosage, is especially emphasized. In males, findings on the impact of T on the male external urethral sphincter underscores that there is still much to learn about its role in male LUT physiology. The important topic of the use of T therapy in the treatment of enuresis in the young, both sexes, is also discussed. The importance of understanding the steroidogenic pathways linking T with estradiol is discussed as being of paramount importance in researching the unique actions of T in the LUT. The overall conclusion is that further research into the role of T in LUT function and dysfunction across genders and age groups (young to old) is extremely important. Neurourol. Urodynam. 36:859-862, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Gene expression changes leading extreme alkaline tolerance in Amur ide (Leuciscus waleckii) inhabiting soda lake

PubMed Central

2013-01-01

Background Amur ide (Leuciscus waleckii) is an economically and ecologically important cyprinid species in Northern Asia. The Dali Nor population living in the soda lake Dali Nor can adapt the extremely high alkalinity, providing us a valuable material to understand the adaptation mechanism against extreme environmental stress in teleost. Results In this study, we generated high-throughput RNA-Seq data from three tissues gill, liver and kidney of L. waleckii living in the soda lake Dali Nor and the fresh water lake Ganggeng Nor, then performed parallel comparisons of three tissues. Our results showed that out of assembled 64,603 transcript contigs, 28,391 contigs had been assigned with a known function, corresponding to 20,371 unique protein accessions. We found 477, 2,761 and 3,376 differentially expressed genes (DEGs) in the gill, kidney, and liver, respectively, of Dali Nor population compared to Ganggeng Nor population with FDR ≤ 0.01and fold-change ≥ 2. Further analysis revealed that well-known functional categories of genes and signaling pathway, which are associated with stress response and extreme environment adaptation, have been significantly enriched, including the functional categories of “response to stimulus”, “transferase activity”, “transporter activity” and “oxidoreductase activity”, and signaling pathways of “mTOR signaling”, “EIF2 signaling”, “superpathway of cholesterol biosynthesis”. We also identified significantly DEGs encoding important modulators on stress adaptation and tolerance, including carbonic anhydrases, heat shock proteins, superoxide dismutase, glutathione S-transferases, aminopeptidase N, and aminotransferases. Conclusions Overall, this study demonstrated that transcriptome changes in L. waleckii played a role in adaptation to complicated environmental stress in the highly alkalized Dali Nor lake. The results set a foundation for further analyses on alkaline-responsive candidate genes, which help us understand teleost adaptation under extreme environmental stress and ultimately benefit future breeding for alkaline-tolerant fish strains. PMID:24094069

Viruses and Breast Cancer

PubMed Central

Lawson, James S.; Heng, Benjamin

2010-01-01

Viruses are the accepted cause of many important cancers including cancers of the cervix and anogenital area, the liver, some lymphomas, head and neck cancers and indirectly human immunodeficiency virus associated cancers. For over 50 years, there have been serious attempts to identify viruses which may have a role in breast cancer. Despite these efforts, the establishment of conclusive evidence for such a role has been elusive. However, the development of extremely sophisticated new experimental techniques has allowed the recent development of evidence that human papilloma virus, Epstein-Barr virus, mouse mammary tumor virus and bovine leukemia virus may each have a role in the causation of human breast cancers. This is potentially good news as effective vaccines are already available to prevent infections from carcinogenic strains of human papilloma virus, which causes cancer of the uterine cervix. PMID:24281093

The combined and separate impacts of climate extremes on the current and future US rainfed maize and soybean production under elevated CO 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, Zhenong; Zhuang, Qianlai; Wang, Jiali

Heat and drought stresses are two emerging climatic threats to the US maize and soybean production, yet their impacts on yields are collectively determined by the magnitude of climate change and rising atmospheric CO2 concentration. Here we present a study that quantified the current and future yield responses of US rainfed maize and soybean to climate extremes, and for the first time characterized spatial shifts in the relative importance of temperature, heat and drought stress. Crop yields are simulated using the Agricultural Production Systems sIMulator (APSIM), driven by the high-resolution (12 km) Weather Research and Forecasting (WRF) Model downscaled futuremore » climate scenarios at two time slices (1995-2005 and 2085-2094). Our results show that climatic yield gaps and interannual variability are greater in the core production area than in the remaining US by the late 21st century under both Representative Concentration Pathway (RCP) 4.5 and RCP8.5 scenarios, and the magnitude of change is highly dependent on the current climate sensitivity and vulnerability. Elevated CO2 partially offsets the climatic yield gaps and reduces interannual yield variability, and effect is more prominent in soybean than in maize. We demonstrate that drought will continue to be the largest threat to US rainfed maize and soybean production, although its dominant role gradually gives way to other impacts of heat extremes. We also reveal that shifts in the geographic distributions of dominant stressors are characterized by increases in the concurrent stress, especially for the US Midwest. These findings imply the importance of considering drought and extreme heat simultaneously for future agronomic adaptation and mitigation strategies, particularly for breeding programs and crop management.« less

[Noncovalent cation-π interactions--their role in nature].

PubMed

Fink, Krzysztof; Boratyński, Janusz

2014-11-07

Non-covalent interactions play an extremely important role in organisms. The main non-covalent interactions in nature are: ion-ion interactions, dipole-dipole interactions, hydrogen bonds, and van der Waals interactions. A new kind of intermolecular interactions--cation-π interactions--is gaining increasing attention. These interactions occur between a cation and a π system. The main contributors to cation-π interactions are electrostatic, polarization and, to a lesser extent, dispersion interactions. At first, cation-π interactions were studied in a gas phase, with metal cation-aromatic system complexes. The characteristics of these complexes are as follows: an increase of cation atomic number leads to a decrease of interaction energy, and an increase of cation charge leads to an increase of interaction energy. Aromatic amino acids bind with metal cations mainly through interactions with their main chain. Nevertheless, cation-π interaction with a hydrophobic side chain significantly enhances binding energy. In water solutions most cations preferentially interact with water molecules rather than aromatic systems. Cation-π interactions occur in environments with lower accessibility to a polar solvent. Cation-π interactions can have a stabilizing role on the secondary, tertiary and quaternary structure of proteins. These interactions play an important role in substrate or ligand binding sites in many proteins, which should be taken into consideration when the screening of effective inhibitors for these proteins is carried out. Cation-π interactions are abundant and play an important role in many biological processes.

Importance of Control Groups When Delineating Antibiotic Use as Risk Factors for Carbapenem-Resistance, Extreme-Drug and Pan-Drug Resistance in Acinetobacter baumannii and Pseudomonas aeruginosa: A Systematic Review and Meta-Analysis.

PubMed

Lim, Cheryl Li Ling; Chua, Alvin Qijia; Teo, Jocelyn Qi Min; Cai, Yiying; Lee, Winnie; Kwa, Andrea Lay-Hoon

2018-06-02

Carbapenem-resistant (CR), extreme-drug-resistant (XDR) & pan-drug-resistant (PDR) AB and PA (AB-PA) pose a huge clinical threat. This study reviews the impact of control groups on association of antecedent antibiotic use & acquisition of CR/XDR/PDR AB-PA. Studies investigating the role of antibiotics as risk factor for CR/XDR/PDR AB-PA acquisition in adult hospitalized patients from 1950 to 2016 were identified with databases. These were divided into 2 groups: antibiotic-resistant versus antibiotic-sensitive pathogens (Group I); versus no infection (Group II). A random effects model was performed. Eighty-five studies (46 AB, 38 PA, 1 both) with 22,396 patients were included. CR, XDR & PDR was investigated in 60, 20 and 2 studies respectively. Prior antibiotic exposure was associated with significant acquisition of CR/XDR/PDR AB-PA in both Groups I and II (p <0.05). Antibiotic classes implicated in both groups include aminoglycosides, carbapenems, glycopeptides and penicillins. Cephalosporin use was not associated with resistance in either group. Fluoroquinolones exposure was only associated with resistance in Group I but not Group II. Control groups play an important role in determining magnitudes of risk estimates for risk factor studies, hence careful selection is necessary. Antibiotic exposure increases acquisition of highly-resistant AB-PA, thus appropriate antibiotic use is imperative. Copyright © 2018. Published by Elsevier Ltd.

Projecting climate change impacts on hydrology: the potential role of daily GCM output

NASA Astrophysics Data System (ADS)

Maurer, E. P.; Hidalgo, H. G.; Das, T.; Dettinger, M. D.; Cayan, D.

2008-12-01

A primary challenge facing resource managers in accommodating climate change is determining the range and uncertainty in regional and local climate projections. This is especially important for assessing changes in extreme events, which will drive many of the more severe impacts of a changed climate. Since global climate models (GCMs) produce output at a spatial scale incompatible with local impact assessment, different techniques have evolved to downscale GCM output so locally important climate features are expressed in the projections. We compared skill and hydrologic projections using two statistical downscaling methods and a distributed hydrology model. The downscaling methods are the constructed analogues (CA) and the bias correction and spatial downscaling (BCSD). CA uses daily GCM output, and can thus capture GCM projections for changing extreme event occurrence, while BCSD uses monthly output and statistically generates historical daily sequences. We evaluate the hydrologic impacts projected using downscaled climate (from the NCEP/NCAR reanalysis as a surrogate GCM) for the late 20th century with both methods, comparing skill in projecting soil moisture, snow pack, and streamflow at key locations in the Western United States. We include an assessment of a new method for correcting for GCM biases in a hybrid method combining the most important characteristics of both methods.

1H, 13C, and 15N backbone and side chain resonance assignments of thermophilic Geobacillus kaustophilus cyclophilin-A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holliday, Michael; Zhang, Fengli; Isern, Nancy G.

2014-04-01

Cyclophilins catalyze the reversible peptidyl-prolyl isomerization of their substrates and are present across all kingdoms of life from humans to bacteria. Although numerous biological roles have now been discovered for cyclophilins, their function was initially ascribed to their chaperone-like activity in protein folding where they catalyze the often rate-limiting step of proline isomerization. This chaperone-like activity may be especially important under extreme conditions where cyclophilins are often over expressed, such as in tumors for human cyclophilins {Lee, 2010 #1167}, but also in organisms that thrive under extreme conditions, such as theromophilic bacteria. Moreover, the reversible nature of the peptidyl-prolyl isomerizationmore » reaction catalyzed by cyclophilins has allowed these enzymes to serve as model systems for probing the role of conformational changes during catalytic turnover {Eisenmesser, 2002 #20;Eisenmesser, 2005 #203}. Thus, we present here the resonance assignments of a thermophilic cyclophilin from Geobacillus kaustophilus derived from deep-sea sediment {Takami, 2004 #1384}. This thermophilic cyclophilin may now be studied at a variety of temperatures to provide insight into the comparative structure, dynamics, and catalytic mechanism of cyclophilins.« less

A new supernova light curve modeling program

NASA Astrophysics Data System (ADS)

Jäger, Zoltán; Nagy, Andrea P.; Biro, Barna I.; Vinkó, József

2017-12-01

Supernovae are extremely energetic explosions that highlight the violent deaths of various types of stars. Studying such cosmic explosions may be important because of several reasons. Supernovae play a key role in cosmic nucleosynthesis processes, and they are also the anchors of methods of measuring extragalactic distances. Several exotic physical processes take place in the expanding ejecta produced by the explosion. We have developed a fast and simple semi-analytical code to model the the light curve of core collapse supernovae. This allows the determination of their most important basic physical parameters, like the the radius of the progenitor star, the mass of the ejected envelope, the mass of the radioactive nickel synthesized during the explosion, among others.

Cognitive and behavioral deficits in premature graduates of intensive care.

PubMed

Perlman, Jeffrey M

2002-12-01

A substantial number of VLBW graduates of intensive care develop cognitive and behavioral problems, even in the absence of neuroimaging abnormalities. Although this article has highlighted the potential, important, contributing role of medical and stressful, neonatal, environmental conditions to the development of these deficits, it is not all-encompassing, and there are additional prenatal (ie, in utero stress, drug exposure) and neonatal (ie, infectious) contributing factors. The long-term, outcome data presented in this article are pertinent to the more mature, VLBW infant, and it remains unclear and critically important to delineate the long-term, neurobehavioral outcome of those extremely low birth-weight survivors born at the cutting limit of viability.

Introduction to Stand-up Meetings in Agile Methods

NASA Astrophysics Data System (ADS)

Hasnain, Eisha; Hall, Tracy

2009-05-01

In recent years, agile methods have become more popular in the software industry. Agile methods are a new approach compared to plan-driven approaches. One of the most important shifts in adopting an agile approach is the central focus given to people in the process. This is exemplified by the independence afforded to developers in the development work they do. This work investigates the opinions of practitioners about daily stand-up meetings in the agile methods and the role of developer in that. For our investigation we joined a yahoo group called "Extreme Programming". Our investigation suggests that although trust is an important factor in agile methods. But stand-ups are not the place to build trust.

Effectiveness of Occupational Therapy Interventions for Lower-Extremity Musculoskeletal Disorders: A Systematic Review.

PubMed

Dorsey, Julie; Bradshaw, Michelle

Lower-extremity (LE) musculoskeletal disorders (MSDs) can have a major impact on the ability to carry out daily activities. The effectiveness of interventions must be examined to enable occupational therapy practitioners to deliver the most appropriate services. This systematic review examined the literature published between 1995 and July 2014 that investigated the effectiveness of occupational therapy interventions for LE MSDs. Forty-three articles met the criteria and were reviewed. Occupational therapy interventions varied on the basis of population subgroup: hip fracture, LE joint replacement, LE amputation or limb loss, and nonsurgical osteoarthritis and pain. The results indicate an overall strong role for occupational therapy in treating clients with LE MSDs. Activity pacing is an effective intervention for nonsurgical LE MSDs, and multidisciplinary rehabilitation is effective for LE joint replacement and amputation. Further research on specific occupational therapy interventions in this important area is needed. Copyright © 2017 by the American Occupational Therapy Association, Inc.

A New Stress-Based Model of Political Extremism

PubMed Central

Canetti-Nisim, Daphna; Halperin, Eran; Sharvit, Keren; Hobfoll, Stevan E.

2011-01-01

Does exposure to terrorism lead to hostility toward minorities? Drawing on theories from clinical and social psychology, we propose a stress-based model of political extremism in which psychological distress—which is largely overlooked in political scholarship—and threat perceptions mediate the relationship between exposure to terrorism and attitudes toward minorities. To test the model, a representative sample of 469 Israeli Jewish respondents was interviewed on three occasions at six-month intervals. Structural Equation Modeling indicated that exposure to terrorism predicted psychological distress (t1), which predicted perceived threat from Palestinian citizens of Israel (t2), which, in turn, predicted exclusionist attitudes toward Palestinian citizens of Israel (t3). These findings provide solid evidence and a mechanism for the hypothesis that terrorism introduces nondemocratic attitudes threatening minority rights. It suggests that psychological distress plays an important role in political decision making and should be incorporated in models drawing upon political psychology. PMID:22140275

Spatial variation in extreme winds predicts large wildfire locations in chaparral ecosystems

NASA Astrophysics Data System (ADS)

Moritz, Max A.; Moody, Tadashi J.; Krawchuk, Meg A.; Hughes, Mimi; Hall, Alex

2010-02-01

Fire plays a crucial role in many ecosystems, and a better understanding of different controls on fire activity is needed. Here we analyze spatial variation in fire danger during episodic wind events in coastal southern California, a densely populated Mediterranean-climate region. By reconstructing almost a decade of fire weather patterns through detailed simulations of Santa Ana winds, we produced the first high-resolution map of where these hot, dry winds are consistently most severe and which areas are relatively sheltered. We also analyzed over half a century of mapped fire history in chaparral ecosystems of the region, finding that our models successfully predict where the largest wildfires are most likely to occur. There is a surprising lack of information about extreme wind patterns worldwide, and more quantitative analyses of their spatial variation will be important for effective fire management and sustainable long-term urban development on fire-prone landscapes.

Environmental assessment of mining industry solid pollution in the mercurial district of Azzaba, northeast Algeria.

PubMed

Seklaoui, M'hamed; Boutaleb, Abdelhak; Benali, Hanafi; Alligui, Fadila; Prochaska, Walter

2016-11-01

To date, there have been few detailed studies regarding the impact of mining and metallogenic activities on solid fractions in the Azzaba mercurial district (northeast Algeria) despite its importance and global similarity with large Hg mines. To assess the degree, distribution, and sources of pollution, a physical inventory of apparent pollution was developed, and several samples of mining waste, process waste, sediment, and soil were collected on regional and local scales to determine the concentration of Hg and other metals according to their existing mineralogical association. Several physico-chemical parameters that are known to influence the pollution distribution are realized. The extremely high concentrations of all metals exceed all norms and predominantly characterize the metallurgic and mining areas; the metal concentrations significantly decrease at significant low distances from these sources. The geo-accumulation index, which is the most realistic assessment method, demonstrates that soils and sediments near waste dumps and abandoned Hg mines are extremely polluted by all analyzed metals. The pollution by these metals decreases significantly with distance, which indicates a limited dispersion. The results of a clustering analysis and an integrated pollution index suggest that waste dumps, which are composed of calcine and condensation wastes, are the main source of pollution. Correlations and principal component analysis reveal the important role of hosting carbonate rocks in limiting pollution and differentiating calcine wastes from condensation waste, which has an extremely high Hg concentration (˃1 %).

Losing your edge: climate change and the conservation value of range-edge populations.

PubMed

Rehm, Evan M; Olivas, Paulo; Stroud, James; Feeley, Kenneth J

2015-10-01

Populations occurring at species' range edges can be locally adapted to unique environmental conditions. From a species' perspective, range-edge environments generally have higher severity and frequency of extreme climatic events relative to the range core. Under future climates, extreme climatic events are predicted to become increasingly important in defining species' distributions. Therefore, range-edge genotypes that are better adapted to extreme climates relative to core populations may be essential to species' persistence during periods of rapid climate change. We use relatively simple conceptual models to highlight the importance of locally adapted range-edge populations (leading and trailing edges) for determining the ability of species to persist under future climates. Using trees as an example, we show how locally adapted populations at species' range edges may expand under future climate change and become more common relative to range-core populations. We also highlight how large-scale habitat destruction occurring in some geographic areas where many species range edge converge, such as biome boundaries and ecotones (e.g., the arc of deforestation along the rainforest-cerrado ecotone in the southern Amazonia), can have major implications for global biodiversity. As climate changes, range-edge populations will play key roles in helping species to maintain or expand their geographic distributions. The loss of these locally adapted range-edge populations through anthropogenic disturbance is therefore hypothesized to reduce the ability of species to persist in the face of rapid future climate change.

Loss of ecosystem productivity with repeated drought: a multi-year experiment to assess the role of drought legacy effects

NASA Astrophysics Data System (ADS)

Smith, M. D.; Knapp, A.; Hoover, D. L.; Avolio, M. L.; Felton, A. J.; Slette, I.; Wilcox, K.

2017-12-01

Climate extremes, such as drought, are increasing in frequency and intensity, and the ecological consequences of these extreme events can be substantial and widespread. Yet, little is known about the factors that determine recovery of ecosystem function post-drought. Such knowledge is particularly important because post-drought recovery periods can be protracted depending on drought legacy effects (e.g., loss key plant populations, altered community structure and/or biogeochemical processes). These drought legacies may alter ecosystem function for many years post-drought and may impact future sensitivity to climate extremes. With forecasts of more frequent drought, there is an imperative to understand whether and how post-drought legacies will affect ecosystem response to future drought events. To address this knowledge gap, we experimentally imposed over an eight year period two extreme growing season droughts, each two years in duration followed by a two-year recovery period, in a central US grassland. We found that aboveground net primary productivity (ANPP) declined dramatically with the first drought and was accompanied by a large shift in plant species composition (loss of C3 forb and increase in C4 grasses). This drought legacy - shift in plant composition - persisted two years post-drought. Yet, despite this legacy, ANPP recovered fully. However, we expected that previously-droughted grassland would be less sensitive to a second extreme drought due to the shift in plant composition. Contrary to this expectation, previously droughted grassland experienced a greater loss in ANPP than grassland that had not experienced drought. Furthermore, previously droughted grassland did not fully recover after the second drought. Thus, the legacy of drought - a shift in plant community composition - increased ecosystem sensitivity to a future extreme drought event.

Temporal Clustering of Regional-Scale Extreme Precipitation Events in Southern Switzerland

NASA Astrophysics Data System (ADS)

Barton, Yannick; Giannakaki, Paraskevi; Von Waldow, Harald; Chevalier, Clément; Pfhal, Stephan; Martius, Olivia

2017-04-01

Temporal clustering of extreme precipitation events on subseasonal time scales is a form of compound extremes and is of crucial importance for the formation of large-scale flood events. Here, the temporal clustering of regional-scale extreme precipitation events in southern Switzerland is studied. These precipitation events are relevant for the flooding of lakes in southern Switzerland and northern Italy. This research determines whether temporal clustering is present and then identifies the dynamics that are responsible for the clustering. An observation-based gridded precipitation dataset of Swiss daily rainfall sums and ECMWF reanalysis datasets are used. To analyze the clustering in the precipitation time series a modified version of Ripley's K function is used. It determines the average number of extreme events in a time period, to characterize temporal clustering on subseasonal time scales and to determine the statistical significance of the clustering. Significant clustering of regional-scale precipitation extremes is found on subseasonal time scales during the fall season. Four high-impact clustering episodes are then selected and the dynamics responsible for the clustering are examined. During the four clustering episodes, all heavy precipitation events were associated with an upperlevel breaking Rossby wave over western Europe and in most cases strong diabatic processes upstream over the Atlantic played a role in the amplification of these breaking waves. Atmospheric blocking downstream over eastern Europe supported this wave breaking during two of the clustering episodes. During one of the clustering periods, several extratropical transitions of tropical cyclones in the Atlantic contributed to the formation of high-amplitude ridges over the Atlantic basin and downstream wave breaking. During another event, blocking over Alaska assisted the phase locking of the Rossby waves downstream over the Atlantic.

Management of complex regional pain syndrome type I in upper extremity-evaluation of continuous stellate ganglion block and continuous infraclavicular brachial plexus block: a pilot study.

PubMed

Toshniwal, Gokul; Sunder, Rani; Thomas, Ronald; Dureja, G P

2012-01-01

Interventional pain management techniques play an important role in the multidisciplinary approach to management of complex regional pain syndrome (CRPS). In this preliminary study we compared the efficacy of continuous stellate ganglion (CSG) block with that of continuous infraclavicular brachial plexus (CIBP) block in management of CRPS type I of upper extremity. Thirty-three patients with CRPS type I of upper extremity were randomly assigned to either CSG or CIBP group. Patients were treated for 1 week with continuous infusion of 0.125% bupivacaine at 2and 5mL/h, respectively. Catheter was removed at 1 week and patients were followed up for 4 weeks. The outcome was evaluated in terms of neuropathic pain scale score (NPSS), edema scores (Grades 0-2), and range of motion (ROM) of all upper extremity joints (Grades 0-2). CIBP group showed statistically significant improvement in NPSS compared with CSG group during the first 12 hours after the procedures (P value <0.05). After 12 hours, the NPSS was comparable between the groups. At 4 weeks, both groups showed clinically significant improvement in edema score and ROM of all upper extremity joints when compared with the baseline. This preliminary study suggests that CIBP block and CSG block may be feasible and effective interventional techniques for the management of CRPS type I of upper extremities. Hence, we recommend a larger well-randomized, well-controlled, clinical trial to confirm our findings and determine if any significant difference exists between the groups in terms of long-term pain relief and functional restoration. Wiley Periodicals, Inc.

Drought as a Catalyst for Early Medieval European Subsistence Crises and Violence

NASA Astrophysics Data System (ADS)

Ludlow, Francis; Cook, Edward; Kostick, Conor; McCormick, Michael

2016-04-01

Tree-ring records provide one of most reliable means of reconstructing past climatic conditions, from longer-term multi-decadal fluctuations in temperature and precipitation to inter-annual variability, including years that experienced extreme weather. When combined with written records of past societal behaviour and the incidence of major societal stresses (e.g., famine, disease, and conflict), such records hold the potential to shed new light on historical interactions between climate and society. Recent years have seen the continued development of long dendroclimatic reconstructions, including, most recently the development of the Old World Drought Atlas (OWDA; Cook et al., 2015) which for the first time makes available a robust reconstruction of spring-summer hydroclimatic conditions and extremes for the greater European region, including the entirety of the Dark Ages. In this paper, we examine the association between hydroclimatic extremes identified in the OWDA and well-dated reports of severe drought in early medieval European annals and chronicles, and find a clear statistical correspondence, further confirming the accuracy of the OWDA and its importance as an independent record of hydroclimatic extremes, a resource that can now be drawn upon in both paleoclimatology and studies of climatic impacts on human society. We proceed to examine the association between hydroclimatic extremes identified in the OWDA and the incidence of a range of major societal stresses (scarcity and famine, epidemic disease, and mass human mortality) drawn from an exhaustive survey of early medieval European annals and chronicles. The outcome of this comparison firmly implicates drought as a significant driver of major societal stresses during early medieval times. Using a record of the violent killings of societal elites recorded on a continuous annual basis in medieval Irish monastic annals, we further examine the role of hydroclimatic extremes as triggers in medieval violence and conflict.

Extreme events following bifurcation to spatiotemporal chaos in a spatially extended microcavity laser

NASA Astrophysics Data System (ADS)

Coulibaly, S.; Clerc, M. G.; Selmi, F.; Barbay, S.

2017-02-01

The occurrence of extreme events in a spatially extended microcavity laser has been recently reported [Selmi et al., Phys. Rev. Lett. 116, 013901 (2016), 10.1103/PhysRevLett.116.013901] to be correlated to emergence of spatiotemporal chaos. In this dissipative system, the role of spatial coupling through diffraction is essential to observe the onset of spatiotemporal complexity. We investigate further the formation mechanism of extreme events by comparing the statistical and dynamical analyses. Experimental measurements together with numerical simulations allow us to assign the quasiperiodicity mechanism as the route to spatiotemporal chaos in this system. Moreover, by investigating the fine structure of the maximum Lyapunov exponent, of the Lyapunov spectrum, and of the Kaplan-Yorke dimension of the chaotic attractor, we are able to deduce that intermittency plays a key role in the proportion of extreme events measured. We assign the observed mechanism of generation of extreme events to quasiperiodic extended spatiotemporal intermittency.

LED-technologies for bright light therapy

NASA Astrophysics Data System (ADS)

Kukhta, M. S.; Sidorenko, E. V.; Simutkin, G. G.; Khomushku, O. M.; Glushkov, G. S.

2018-05-01

The significance of the LED-based medical equipment design is caused by the need to make up for the sunshine shortfall in many areas of Russia (Siberia, the Far East, the Extreme North) that will allow reducing dramatically the risk of seasonal affective disorders. The sunshine is the essential synchronizer of the human biological rhythms, the abnormality of which plays an important role in the seasonal affective disorder nature. The study allows proving the object database development able to meet the human demand for a comfortable and high-quality placemaking as well as the health potential recoverability.

Bone Scanning in the Adductor Insertion Avulsion Syndrome

PubMed Central

Mahajan, Madhuri Shimpi

2013-01-01

A thigh splint (adductor insertion avulsion syndrome) is a relatively uncommon diagnosis analogous to shin splints. This article reports a 19-year-old female patient NOT a regular athlete who presented with groin pain. Physical examination was non-specific; magnetic resonance imaging pelvis did not reveal any abnormality. Patient referred for whole body bone scan, especially to locate any abnormality in the spine. This study highlights the role of whole body bone scan in the evaluation of groin pain and importance of evaluation of whole lower extremity. PMID:25126001

Multi-cultural components and keys for European worldwide space programs

NASA Astrophysics Data System (ADS)

Pinotti, Roberto

1991-12-01

The role of different cultures in space missions is considered with regard to NASA and ESA astronauts and Russian cosmonauts. The identification of all the psychological and socio-anthropological components in the behavior of human groups in space is extremely important to understand and solve different problems and obtain the mission's success. In this light, the creation of a multicultural atmosphere aboard is considered a positive aspect for future space programs, and the synthesis of European cultural elements is a definite key to develop morale and productivity.

[Macrophage activation in atherosclerosis. Message 1: Activation of macrophages normally and in atherosclerotic lesions].

PubMed

Nikiforov, N G; Kornienko, V Y; Karagodin, V P; Orekhov, A N

2015-01-01

Macrophages play important role in initiation and progression of inflammation in atherosclerosis. Plaque macrophages were shown to exhibit a phenotypic range that is intermediate between two extremes, M1 (proinflammatory) and M2 (anti-inflammatory). Indeed, in atherosclerosis, macrophages demonstrate phenotypic plasticity to rapidly adjust to changing microenvironmental conditions. In plaque macrophages demonstrate different phenotypes, and besides macrophage phenotypes could be changed. Phenotypes M1, M2, M4, Mhem, HA-mac, M(Hb) u Mox are described in the article. Ability of macrophages change their phenotype also considered.

Iridium-Catalyzed Asymmetric Hydrogenation of Ketones with Accessible and Modular Ferrocene-Based Amino-phosphine Acid (f-Ampha) Ligands.

PubMed

Yu, Jianfei; Long, Jiao; Yang, Yuhong; Wu, Weilong; Xue, Peng; Chung, Lung Wa; Dong, Xiu-Qin; Zhang, Xumu

2017-02-03

A series of tridentate ferrocene-based amino-phosphine acid (f-Ampha) ligands have been successfully developed. The f-Ampha ligands are extremely air stable and exhibited excellent performance in the Ir-catalyzed asymmetric hydrogenation of ketones (full conversions, up to >99% ee, and 500 000 TON). DFT calculations were performed to elucidate the reaction mechanism and the importance of the -COOH group. Control experiments also revealed that the -COOH group played a key role in this reaction.

The analysis of dependence between extreme rainfall and storm surge in the coastal zone

NASA Astrophysics Data System (ADS)

Zheng, F.; Westra, S.

2012-12-01

Flooding in coastal catchments can be caused by runoff generated by an extreme rainfall event, elevated sea levels due to an extreme storm surge event, or the combination of both processes occurring simultaneously or in close succession. Dependence in extreme rainfall and storm surge arises because common meteorological forcings often drive both variables; for example, cyclonic systems may produce extreme rainfall, strong onshore winds and an inverse barometric effect simultaneously, which the former factor influencing catchment discharge and the latter two factors influencing storm surge. Nevertheless there is also the possibility that only one of the variables is extreme at any given time, so that the dependence between rainfall and storm surge is not perfect. Quantification of the strength of dependence between these processes is critical in evaluating the magnitude of flood risk in the coastal zone. This may become more important in the future as the majority of the coastal areas are threatened by the sea level rise due to the climate change. This research uses the most comprehensive record of rainfall and storm surge along the coastline of Australia collected to-date to investigate the strength of dependence between the extreme rainfall and storm surge along the Australia coastline. A bivariate logistic threshold-excess model was employed to this end to carry out the dependence analysis. The strength of the estimated dependence is then evaluated as a function of several factors including: the distance between the tidal gauge and the rain gauge; the lag between the extreme precipitation event and extreme surge event; and the duration of the maximum storm burst. The results show that the dependence between the extreme rainfall and storm surge along the Australia coastline is statistically significant, although some locations clearly exhibit stronger dependence than others. We hypothesize that this is due to a combination of large-scale meteorological effects as well as local scale bathymetry. Additionally, significant dependence can be observed over spatial distances of up to several hundred kilometers, implying that meso-scale meteorological forcings may play an important role in driving the dependence. This is also consistent with the result which shows that significant dependence often remaining for lags of up to one or two days between extremal rainfall and storm surge events. The influence of storm burst duration can also be observed, with rainfall extremes lasting more than several hours typically being more closely associated with storm surge compared with sub-hourly rainfall extremes. These results will have profound implications for how flood risk is evaluated along the coastal zone in Australia, with the strength of dependence varying depending on: (1) the dominant meteorological conditions; (2) the local estuary configuration, influencing the strength of the surge; and (3) the catchment attributes, influencing the duration of the storm burst that will deliver the peak flood events. Although a strong random component remains, we show that the probability of an extreme storm surge during an extreme rainfall event (or vice versa) can be up to ten times greater than under the situation under which there is no dependence, suggesting that failure to account for these interactions can result in a substantial underestimation of flood risk.

A basis set for exploration of sensitivity to prescribed ocean conditions for estimating human contributions to extreme weather in CAM5.1-1degree

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, Dáithí A.; Risser, Mark D.; Angélil, Oliver M.

This paper presents two contributions for research into better understanding the role of anthropogenic warming in extreme weather. The first contribution is the generation of a large number of multi-decadal simulations using a medium-resolution atmospheric climate model, CAM5.1-1degree, under two scenarios of historical climate following the protocols of the C20C+ Detection and Attribution project: the one we have experienced (All-Hist), and one that might have been experienced in the absence of human interference with the climate system (Nat-Hist). These simulations are also specifically designed for understanding extreme weather and atmospheric variability in the context of anthropogenic climate change.The second contributionmore » takes advantage of the duration and size of these simulations in order to identify features of variability in the prescribed ocean conditions that may strongly influence calculated estimates of the role of anthropogenic emissions on extreme weather frequency (event attribution). There is a large amount of uncertainty in how much anthropogenic emissions should warm regional ocean surface temperatures, yet contributions to the C20C+ Detection and Attribution project and similar efforts so far use only one or a limited number of possible estimates of the ocean warming attributable to anthropogenic emissions when generating their Nat-Hist simulations. Thus, the importance of the uncertainty in regional attributable warming estimates to the results of event attribution studies is poorly understood. The identification of features of the anomalous ocean state that seem to strongly influence event attribution estimates should therefore be able to serve as a basis set for effective sampling of other plausible attributable warming patterns. The identification performed in this paper examines monthly temperature and precipitation output from the CAM5.1-1degree simulations averaged over 237 land regions, and compares interannual anomalous variations in the ratio between the frequencies of extremes in the All-Hist and Nat-Hist simulations against variations in ocean temperatures.« less

A basis set for exploration of sensitivity to prescribed ocean conditions for estimating human contributions to extreme weather in CAM5.1-1degree

DOE PAGES

Stone, Dáithí A.; Risser, Mark D.; Angélil, Oliver M.; ...

2018-03-01

This paper presents two contributions for research into better understanding the role of anthropogenic warming in extreme weather. The first contribution is the generation of a large number of multi-decadal simulations using a medium-resolution atmospheric climate model, CAM5.1-1degree, under two scenarios of historical climate following the protocols of the C20C+ Detection and Attribution project: the one we have experienced (All-Hist), and one that might have been experienced in the absence of human interference with the climate system (Nat-Hist). These simulations are also specifically designed for understanding extreme weather and atmospheric variability in the context of anthropogenic climate change.The second contributionmore » takes advantage of the duration and size of these simulations in order to identify features of variability in the prescribed ocean conditions that may strongly influence calculated estimates of the role of anthropogenic emissions on extreme weather frequency (event attribution). There is a large amount of uncertainty in how much anthropogenic emissions should warm regional ocean surface temperatures, yet contributions to the C20C+ Detection and Attribution project and similar efforts so far use only one or a limited number of possible estimates of the ocean warming attributable to anthropogenic emissions when generating their Nat-Hist simulations. Thus, the importance of the uncertainty in regional attributable warming estimates to the results of event attribution studies is poorly understood. The identification of features of the anomalous ocean state that seem to strongly influence event attribution estimates should therefore be able to serve as a basis set for effective sampling of other plausible attributable warming patterns. The identification performed in this paper examines monthly temperature and precipitation output from the CAM5.1-1degree simulations averaged over 237 land regions, and compares interannual anomalous variations in the ratio between the frequencies of extremes in the All-Hist and Nat-Hist simulations against variations in ocean temperatures.« less

A Millennial Challenge: Extremism in Uncertain Times

PubMed Central

Fiske, Susan T.

2014-01-01

This comment highlights the relevance and importance of the uncertainty-extremism topic, both scientifically and societally, identifies common themes, locates this work in a wider scientific and social context, describes what we now know and what we still do not, acknowledges some limitations, foreshadowing future directions, and discusses some potential policy relevance. Common themes emerge around the importance of social justice as sound anti-extremism policy. PMID:24511155

Allelopathic and Bloom-Forming Picocyanobacteria in a Changing World

PubMed Central

Maculewicz, Jakub; Barreiro Felpeto, Aldo; Latała, Adam

2018-01-01

Picocyanobacteria are extremely important organisms in the world’s oceans and freshwater ecosystems. They play an essential role in primary production and their domination in phytoplankton biomass is common in both oligotrophic and eutrophic waters. Their role is expected to become even more relevant with the effect of climate change. However, this group of photoautotrophic organisms still remains insufficiently recognized. Only a few works have focused in detail on the occurrence of massive blooms of picocyanobacteria, their toxicity and allelopathic activity. Filling the gap in our knowledge about the mechanisms involved in the proliferation of these organisms could provide a better understanding of aquatic environments. In this review, we gathered and described recent information about allelopathic activity of picocyanobacteria and occurrence of their massive blooms in many aquatic ecosystems. We also examined the relationships between climate change and representative picocyanobacterial genera from freshwater, brackish and marine ecosystems. This work emphasizes the importance of studying the smallest picoplanktonic fractions of cyanobacteria. PMID:29361682

The niche of an invasive marine microbe in a subtropical freshwater impoundment

PubMed Central

David Hambright, K; Beyer, Jessica E; Easton, James D; Zamor, Richard M; Easton, Anne C; Hallidayschult, Thayer C

2015-01-01

Growing attention in aquatic ecology is focusing on biogeographic patterns in microorganisms and whether these potential patterns can be explained within the framework of general ecology. The long-standing microbiologist's credo ‘Everything is everywhere, but, the environment selects' suggests that dispersal is not limiting for microbes, but that the environment is the primary determining factor in microbial community composition. Advances in molecular techniques have provided new evidence that biogeographic patterns exist in microbes and that dispersal limitation may actually have an important role, yet more recent study using extremely deep sequencing predicts that indeed everything is everywhere. Using a long-term field study of the ‘invasive' marine haptophyte Prymnesium parvum, we characterize the environmental niche of P. parvum in a subtropical impoundment in the southern United States. Our analysis contributes to a growing body of evidence that indicates a primary role for environmental conditions, but not dispersal, in the lake-wide abundances and seasonal bloom patterns in this globally important microbe. PMID:24950108

Proteinuria and Hematuria in the Neonate

PubMed Central

Joseph, Catherine; Gattineni, Jyothsna

2016-01-01

Purpose of Review Neonatal proteinuria and hematuria while not common can have potentially devastating consequences if left undiagnosed and untreated. It is important to distinguish between inherited and acquired causes of proteinuria to initiate appropriate and timely treatment. In regards to hematuria, it is critical to identify true hematuria from pseudo-hematuria in order to balance between thorough investigation and unnecessary laboratory work up. This review provides an overview of the common causes of hematuria and proteinuria in a neonate. Recent Findings Identification of genetic mutations in nephrotic syndrome has improved our understanding of the role of various proteins that play an important role in maintaining the glomerular filtration barrier. With the advancement in our ability to provide care for extreme premature neonates, the incidence of acute kidney injury has increased in these neonates along with proteinuria and hematuria. Summary Persistent proteinuria after neonatal acute kidney injury would be of interest in regards to the risk of developing future chronic kidney disease and hypertension. PMID:26845146

A walk on the tundra: Host-parasite interactions in an extreme environment.

PubMed

Kutz, Susan J; Hoberg, Eric P; Molnár, Péter K; Dobson, Andy; Verocai, Guilherme G

2014-08-01

Climate change is occurring very rapidly in the Arctic, and the processes that have taken millions of years to evolve in this very extreme environment are now changing on timescales as short as decades. These changes are dramatic, subtle and non-linear. In this article, we discuss the evolving insights into host-parasite interactions for wild ungulate species, specifically, muskoxen and caribou, in the North American Arctic. These interactions occur in an environment that is characterized by extremes in temperature, high seasonality, and low host species abundance and diversity. We believe that lessons learned in this system can guide wildlife management and conservation throughout the Arctic, and can also be generalized to more broadly understand host-parasite interactions elsewhere. We specifically examine the impacts of climate change on host-parasite interactions and focus on: (I) the direct temperature effects on parasites; (II) the importance of considering the intricacies of host and parasite ecology for anticipating climate change impacts; and (III) the effect of shifting ecological barriers and corridors. Insights gained from studying the history and ecology of host-parasite systems in the Arctic will be central to understanding the role that climate change is playing in these more complex systems.

Salinity- and population-dependent genome regulatory response during osmotic acclimation in the killifish (Fundulus heteroclitus) gill.

PubMed

Whitehead, Andrew; Roach, Jennifer L; Zhang, Shujun; Galvez, Fernando

2012-04-15

The killifish Fundulus heteroclitus is abundant in osmotically dynamic estuaries and it can quickly adjust to extremes in environmental salinity. We performed a comparative osmotic challenge experiment to track the transcriptomic and physiological responses to two salinities throughout a time course of acclimation, and to explore the genome regulatory mechanisms that enable extreme osmotic acclimation. One southern and one northern coastal population, known to differ in their tolerance to hypo-osmotic exposure, were used as our comparative model. Both populations could maintain osmotic homeostasis when transferred from 32 to 0.4 p.p.t., but diverged in their compensatory abilities when challenged down to 0.1 p.p.t., in parallel with divergent transformation of gill morphology. Genes involved in cell volume regulation, nucleosome maintenance, ion transport, energetics, mitochondrion function, transcriptional regulation and apoptosis showed population- and salinity-dependent patterns of expression during acclimation. Network analysis confirmed the role of cytokine and kinase signaling pathways in coordinating the genome regulatory response to osmotic challenge, and also posited the importance of signaling coordinated through the transcription factor HNF-4α. These genome responses support hypotheses of which regulatory mechanisms are particularly relevant for enabling extreme physiological flexibility.

A walk on the tundra: Host–parasite interactions in an extreme environment

PubMed Central

Kutz, Susan J.; Hoberg, Eric P.; Molnár, Péter K.; Dobson, Andy; Verocai, Guilherme G.

2014-01-01

Climate change is occurring very rapidly in the Arctic, and the processes that have taken millions of years to evolve in this very extreme environment are now changing on timescales as short as decades. These changes are dramatic, subtle and non-linear. In this article, we discuss the evolving insights into host–parasite interactions for wild ungulate species, specifically, muskoxen and caribou, in the North American Arctic. These interactions occur in an environment that is characterized by extremes in temperature, high seasonality, and low host species abundance and diversity. We believe that lessons learned in this system can guide wildlife management and conservation throughout the Arctic, and can also be generalized to more broadly understand host–parasite interactions elsewhere. We specifically examine the impacts of climate change on host–parasite interactions and focus on: (I) the direct temperature effects on parasites; (II) the importance of considering the intricacies of host and parasite ecology for anticipating climate change impacts; and (III) the effect of shifting ecological barriers and corridors. Insights gained from studying the history and ecology of host–parasite systems in the Arctic will be central to understanding the role that climate change is playing in these more complex systems. PMID:25180164

Dolphin social intelligence: complex alliance relationships in bottlenose dolphins and a consideration of selective environments for extreme brain size evolution in mammals.

PubMed

Connor, Richard C

2007-04-29

Bottlenose dolphins in Shark Bay, Australia, live in a large, unbounded society with a fission-fusion grouping pattern. Potential cognitive demands include the need to develop social strategies involving the recognition of a large number of individuals and their relationships with others. Patterns of alliance affiliation among males may be more complex than are currently known for any non-human, with individuals participating in 2-3 levels of shifting alliances. Males mediate alliance relationships with gentle contact behaviours such as petting, but synchrony also plays an important role in affiliative interactions. In general, selection for social intelligence in the context of shifting alliances will depend on the extent to which there are strategic options and risk. Extreme brain size evolution may have occurred more than once in the toothed whales, reaching peaks in the dolphin family and the sperm whale. All three 'peaks' of large brain size evolution in mammals (odontocetes, humans and elephants) shared a common selective environment: extreme mutual dependence based on external threats from predators or conspecific groups. In this context, social competition, and consequently selection for greater cognitive abilities and large brain size, was intense.

Phase transformation in tantalum under extreme laser deformation

DOE PAGES

Lu, C. -H.; Hahn, E. N.; Remington, B. A.; ...

2015-10-19

The structural and mechanical response of metals is intimately connected to phase transformations. For instance, the product of a phase transformation (martensite) is responsible for the extraordinary range of strength and toughness of steel, making it a versatile and important structural material. Although abundant in metals and alloys, the discovery of new phase transformations is not currently a common event and often requires a mix of experimentation, predictive computations, and luck. High-energy pulsed lasers enable the exploration of extreme pressures and temperatures, where such discoveries may lie. The formation of a hexagonal (omega) phase was observed in recovered monocrystalline body-centeredmore » cubic tantalum of four crystallographic orientations subjected to an extreme regime of pressure, temperature, and strain-rate. This was accomplished using high-energy pulsed lasers. The omega phase and twinning were identified by transmission electron microscopy at 70 GPa (determined by a corresponding VISAR experiment). It is proposed that the shear stresses generated by the uniaxial strain state of shock compression play an essential role in the transformation. In conclusion, molecular dynamics simulations show the transformation of small nodules from body-centered cubic to a hexagonal close-packed structure under the same stress state (pressure and shear).« less

Phase Transformation in Tantalum under Extreme Laser Deformation

PubMed Central

Lu, C.-H.; Hahn, E. N.; Remington, B. A.; Maddox, B. R.; Bringa, E. M.; Meyers, M. A.

2015-01-01

The structural and mechanical response of metals is intimately connected to phase transformations. For instance, the product of a phase transformation (martensite) is responsible for the extraordinary range of strength and toughness of steel, making it a versatile and important structural material. Although abundant in metals and alloys, the discovery of new phase transformations is not currently a common event and often requires a mix of experimentation, predictive computations, and luck. High-energy pulsed lasers enable the exploration of extreme pressures and temperatures, where such discoveries may lie. The formation of a hexagonal (omega) phase was observed in recovered monocrystalline body-centered cubic tantalum of four crystallographic orientations subjected to an extreme regime of pressure, temperature, and strain-rate. This was accomplished using high-energy pulsed lasers. The omega phase and twinning were identified by transmission electron microscopy at 70 GPa (determined by a corresponding VISAR experiment). It is proposed that the shear stresses generated by the uniaxial strain state of shock compression play an essential role in the transformation. Molecular dynamics simulations show the transformation of small nodules from body-centered cubic to a hexagonal close-packed structure under the same stress state (pressure and shear). PMID:26478106

Social Mediation of Persuasive Media in Adolescent Substance Prevention

PubMed Central

Crano, William D.; Alvaro, Eusebio M.; Tan, Cara N.; Siegel, Jason T.

2017-01-01

Social commentary about prevention messages may affect their likelihood of acceptance. To investigate this possibility, student participants (N = 663) viewed three anti-marijuana advertisements, each followed immediately by videotaped discussions involving four adults or four adolescents using either extreme or moderate language in their positive commentaries. The commentaries were expected to affect participants’ perceptions of the extent to which the ads were designed to control their behavior (perceived control), which was hypothesized to inhibit persuasion. Two indirect effects analyses were conducted. Marijuana attitudes and usage intentions were the outcome variables. Both analyses revealed statistically significant source by language interactions on participants’ perceived control (both p < .02). Further analyses revealed significant indirect effects of language extremity on attitudes and intentions through perceived control with adult, but not peer sources (both p < .05). These perceptions were associated with more negative marijuana attitudes and diminished usage intentions when adults used moderate (vs. extreme) language in their favorable ad commentaries (both p < .05). The findings may facilitate development of more effective prevention methods that emphasize the importance the role of perceived control in persuasion, and the impact of interpersonal communication variations on acceptance of media-transmitted prevention messages. PMID:28301181

Open mHealth Architecture: A Primer for Tomorrow's Orthopedic Surgeon and Introduction to Its Use in Lower Extremity Arthroplasty.

PubMed

Ramkumar, Prem N; Muschler, George F; Spindler, Kurt P; Harris, Joshua D; McCulloch, Patrick C; Mont, Michael A

2017-04-01

The recent private-public partnership to unlock and utilize all available health data has large-scale implications for public health and personalized medicine, especially within orthopedics. Today, consumer based technologies such as smartphones and "wearables" store tremendous amounts of personal health data (known as "mHealth") that, when processed and contextualized, have the potential to open new windows of insight for the orthopedic surgeon about their patients. In the present report, the landscape, role, and future technical considerations of mHealth and open architecture are defined with particular examples in lower extremity arthroplasty. A limitation of the current mHealth landscape is the fragmentation and lack of interconnectivity between the myriad of available apps. The importance behind the currently lacking open mHealth architecture is underscored by the offer of improved research, increased workflow efficiency, and value capture for the orthopedic surgeon. There exists an opportunity to leverage existing mobile health data for orthopaedic surgeons, particularly those specializing in lower extremity arthroplasty, by transforming patient small data into insightful big data through the implementation of "open" architecture that affords universal data standards and a global interconnected network. Copyright © 2016 Elsevier Inc. All rights reserved.

Postural control in man: the phylogenetic perspective.

PubMed

Gramsbergen, Albert

2005-01-01

Erect posture in man is a recent affordance from an evolutionary perspective. About eight million years ago, the stock from which modern humans derived split off from the ape family, and from around sixty-thousand years ago, modern man developed. Upright gait and manipulations while standing pose intricate cybernetic problems for postural control. The trunk, having an older evolutionary history than the extremities, is innervated by medially descending motor systems and extremity muscles by the more recent, laterally descending systems. Movements obviously require concerted actions from both systems. Research in rats has demonstrated the interdependencies between postural control and the development of fluent walking. Only 15 days after birth, adult-like fluent locomotion emerges and is critically dependent upon postural development. Vesttibular deprivation induces a retardation in postural development and, consequently, a retarded development of adult-like locomotion. The cerebellum obviously has an important role in mutual adjustments in postural control and extremity movements, or, in coupling the phylogenetic older and newer structures. In the human, the cerebellum develops partly after birth and therefore is vulnerable to adverse perinatal influences. Such vulnerability seems to justify focusing our scientific research efforts onto the development of this structure.

Social mediation of persuasive media in adolescent substance prevention.

PubMed

Crano, William D; Alvaro, Eusebio M; Tan, Cara N; Siegel, Jason T

2017-06-01

Social commentary about prevention messages may affect their likelihood of acceptance. To investigate this possibility, student participants (N = 663) viewed 3 antimarijuana advertisements, each followed immediately by videotaped discussions involving 4 adults or 4 adolescents using either extreme or moderate language in their positive commentaries. The commentaries were expected to affect participants' perceptions of the extent to which the ads were designed to control their behavior (perceived control), which was hypothesized to inhibit persuasion. Two indirect effects analyses were conducted. Marijuana attitudes and usage intentions were the outcome variables. Both analyses revealed statistically significant source by language interactions on participants' perceived control (both p < .02). Further analyses revealed significant indirect effects of language extremity on attitudes and intentions through perceived control with adult, but not peer sources (both p < .05). These perceptions were associated with more negative marijuana attitudes and diminished usage intentions when adults used moderate (vs. extreme) language in their favorable ad commentaries (both p < .05). The findings may facilitate development of more effective prevention methods that emphasize the importance of the role of perceived control in persuasion, and the impact of interpersonal communication variations on acceptance of media-transmitted prevention messages. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Analysis of muscle activation in lower extremity for static balance.

PubMed

Chakravarty, Kingshuk; Chatterjee, Debatri; Das, Rajat Kumar; Tripathy, Soumya Ranjan; Sinha, Aniruddha

2017-07-01

Balance plays an important role for human bipedal locomotion. Degeneration of balance control is prominent in stroke patients, elderly adults and even for majority of obese people. Design of personalized balance training program, in order to strengthen muscles, requires the analysis of muscle activation during an activity. In this paper we have proposed an affordable and portable approach to analyze the relationship between the static balance strategy and activation of various lower extremity muscles. To do that we have considered Microsoft Kinect XBox 360 as a motion sensing device and Wii balance board for measuring external force information. For analyzing the muscle activation pattern related to static balance, participants are asked to do the single limb stance (SLS) exercise on the balance board and in front of the Kinect. Static optimization to minimize the overall muscle activation pattern is carried out using OpenSim, which is an open-source musculoskeletal simulation software. The study is done on ten normal and ten obese people, grouped according to body mass index (BMI). Results suggest that the lower extremity muscles like biceps femoris, psoas major, sartorius, iliacus play the major role for both maintaining the balance using one limb as well as maintaining the flexion of the other limb during SLS. Further investigations reveal that the higher muscle activations of the flexed leg for normal group demonstrate higher strength. Moreover, the lower muscle activation of the standing leg for normal group demonstrate more headroom for the biceps femoris-short-head and psoas major to withstand the load and hence have better static balance control.

Changes in temperature and precipitation extremes in western central Africa, Guinea Conakry, and Zimbabwe, 1955-2006

NASA Astrophysics Data System (ADS)

Aguilar, E.; Aziz Barry, A.; Brunet, M.; Ekang, L.; Fernandes, A.; Massoukina, M.; Mbah, J.; Mhanda, A.; Do Nascimento, D. J.; Peterson, T. C.; Thamba Umba, O.; Tomou, M.; Zhang, X.

2009-01-01

Understanding how extremes are changing globally, regionally, and locally is an important first step for planning appropriate adaptation measures, as changes in extremes have major impacts. The Intergovernmental Panel on Climate Change's synthesis of global extremes was not able to say anything about western central Africa, as no analysis of the region was available nor was there an adequate internationally exchanged long-term daily data set available to use for analysis of extremes. This paper presents the first analysis of extremes in this climatically important region along with analysis of Guinea Conakry and Zimbabwe. As per many other parts of the world, the analysis shows a decrease in cold extremes and an increase in warm extremes. However, while the majority of the analyzed world has shown an increase in heavy precipitation over the last half century, central Africa showed a decrease. Furthermore, the companion analysis of Guinea Conakry and Zimbabwe showed no significant increases.

Predicting the solubility of gases in Nitrile Butadiene Rubber in extreme conditions using molecular simulation

NASA Astrophysics Data System (ADS)

Khawaja, Musab; Molinari, Nicola; Sutton, Adrian; Mostofi, Arash

In the oil and gas industry, elastomer seals play an important role in protecting sensitive monitoring equipment from contamination by gases - a problem that is exacerbated by the high pressures and temperatures found down-hole. The ability to predict and prevent such permeative failure has proved elusive to-date. Nitrile butadiene rubber (NBR) is a common choice of elastomer for seals due to its resistance to heat and fuels. In the conditions found in the well it readily absorbs small molecular weight gases. How this behaviour changes quantitatively for different gases as a function of temperature and pressure is not well-understood. In this work a series of fully atomistic simulations are performed to understand the effect of extreme conditions on gas solubility in NBR. Widom particle insertion is used to compute solubilities. The importance of sampling and allowing structural relaxation upon compression are highlighted, and qualitatively reasonable trends reproduced. Finally, while at STP it has previously been shown that the solubility of CO2 is higher than that of He in NBR, we observe that under the right circumstances it is possible to reverse this trend.

[Driving under the influence of benzodiazepines and antidepressants: prescription and abuse].

PubMed

Coutinho, Daniel; Vieira, Duarte Nuno; Teixeira, Helena M

2011-01-01

Benzodiazepines are drugs usually used in anxiety disorders, dyssomnias, convulsions, muscle disorders, alcohol and other drugs detoxification, as well as in preoperative sedation/amnesia. Moreover, antidepressants are mainly indicated in depression and as co-therapeutic drugs in other psychiatric disorders. The use of benzodiazepines and antidepressants is associated with some health and public safety problems. Decreased of attention, concentration, reflexes, visual capacity, motor coordination and reasoning, associated with increased reaction time and lack of awareness of driving impairment among these drug users, contributes to the increased risk on traffic safety linked with these drugs. This risk may further increase with non-compliance of medical prescription, drug abuse or concomitant use of alcohol. The relationship between the use of psychoactive drugs and road traffic safety is, however, an extremely complex subject and has a primordial importance in the clarification of the role of benzodiazepine and antidepressant effects on driving skills. The prevention of driving under the influence of these drugs depends on the awareness, among doctors, of the risks associated with their use. Thus, the consciousness of medical prescription, as well as providing clear information to patients is extremely important.

Rapid formation and evolution of an extreme haze episode in Northern China during winter 2015

PubMed Central

Sun, Yele; Chen, Chen; Zhang, Yingjie; Xu, Weiqi; Zhou, Libo; Cheng, Xueling; Zheng, Haitao; Ji, Dongsheng; Li, Jie; Tang, Xiao; Fu, Pingqing; Wang, Zifa

2016-01-01

We investigate the rapid formation and evolutionary mechanisms of an extremely severe and persistent haze episode that occurred in northern China during winter 2015 using comprehensive ground and vertical measurements, along with receptor and dispersion model analysis. Our results indicate that the life cycle of a severe winter haze episode typically consists of four stages: (1) rapid formation initiated by sudden changes in meteorological parameters and synchronous increases in most aerosol species, (2) persistent evolution with relatively constant variations in secondary inorganic aerosols and secondary organic aerosols, (3) further evolution associated with fog processing and significantly enhanced sulfate levels, and (4) clearing due to dry, cold north-northwesterly winds. Aerosol composition showed substantial changes during the formation and evolution of the haze episode but was generally dominated by regional secondary aerosols (53–67%). Our results demonstrate the important role of regional transport, largely from the southwest but also from the east, and of coal combustion emissions for winter haze formation in Beijing. Also, we observed an important downward mixing pathway during the severe haze in 2015 that can lead to rapid increases in certain aerosol species. PMID:27243909

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.

PubMed

Nisar, Shaista; Daly, Martina E; Federici, Augusto B; Artoni, Andrea; Mumford, Andrew D; Watson, Stephen P; Mundell, Stuart J

2011-11-17

The platelet P2Y(12) purinoceptor (P2Y(12)R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y(12)R function is compromised after deletion or mutation of the 4 amino acids at the extreme C-terminus of this receptor (ETPM), a putative postsynaptic density 95/disc large/zonula occludens-1 (PDZ)-binding motif. In cell line models, removal of this sequence or mutation of one of its core residues (P341A), attenuates receptor internalization and receptor recycling back to the membrane, thereby blocking receptor resensitization. The physiologic significance of these findings in the regulation of platelet function is shown by identification of a patient with a heterozygous mutation in the PDZ binding sequence of their P2Y(12)R (P341A) that is associated with reduced expression of the P2Y(12)R on the cell surface. Importantly, platelets from this subject showed significantly compromised P2Y(12)R recycling, emphasizing the importance of the extreme C-terminus of this receptor to ensure correct receptor traffic.

Trends and Projections of Climatic Extremes in the Black Volta Basin, West Africa: Towards Climate Change Adaptation.

NASA Astrophysics Data System (ADS)

Aziz, F.

2015-12-01

The water resources of the Black Volta Basin in West Africa constitute a major resource for the four countries (Burkina Faso, Ghana, Côte d'Ivoire, Mali) that share it. For Burkina Faso and Ghana, the river is the main natural resource around which the development of the diverse sectors of the two economies is built. Whereas Ghana relies heavily on the river for energy, land-locked Burkina Faso continuously develops the water for agricultural purposes. Such important role of the river makes it an element around which there are potential conflicts: either among riparian countries or within the individual countries themselves. This study documents the changes in temperature and precipitation extremes in the Black Volta Basin region for the past (1981-2010) and makes projections for the mid-late 21st century (2051-2080) under two emission scenarios; RCP 2.6 and RCP 8.5. The Expert Team on Climate Change Detection and Indices (ETCCDI) temperature- and precipitation-based indices are computed with the RClimdex software. Observed daily records and downscaled CORDEX data of precipitation and maximum and minimum temperatures are used for historical and future trend analysis respectively. In general low emission scenarios show increases in the cold extremes. The region shows a consistent pattern of trends in hot extremes for the 1990's. An increasing trend in hot extremes is expected in the future under RCP 8.5 while RCP 2.5 shows reductions in hot extremes. Regardless of the emission scenario, projections show more frequent hot nights in the 21st century. Generally, the region shows variability in trends for future extreme precipitation indices with only a few of the trends being statistically significant (5% level). Results obtained provide a basic and first step to understanding how climatic extremes have been changing in the Volta Basin region and gives an idea of what to expect in the future. Such studies will also help in making informed decisions on water management in the basin. The various water users; agriculture, household, industries will be able to prepare adequately and adapt to changes when they have information of the trends of extreme events well ahead of time.

Abrupt shifts in ecosystem function and intensification of global biogeochemical cycle driven by hydroclimatic extremes

NASA Astrophysics Data System (ADS)

Ma, Xuanlong; Huete, Alfredo; Ponce-Campos, Guillermo; Zhang, Yongguang; Xie, Zunyi; Giovannini, Leandro; Cleverly, James; Eamus, Derek

2016-04-01

Amplification of the hydrologic cycle as a consequence of global warming is increasing the frequency, intensity, and spatial extent of extreme climate events globally. The potential influences resulting from amplification of the hydro-climatic cycle, coupled with an accelerating warming trend, pose great concerns on the sustainability of terrestrial ecosystems to sequester carbon, maintain biodiversity, provide ecosystem services, food security, and support human livelihood. Despite the great implications, the magnitude, direction, and carry-over effect of these extreme climate events on ecosystem function, remain largely uncertain. To address these pressing issues, we conducted an observational, interdisciplinary study using satellite retrievals of atmospheric CO2 and photosynthesis (chlorophyll fluorescence), and in-situ flux tower measures of ecosystem-atmosphere carbon exchange, to reveal the shifts in ecosystem function across extreme drought and wet periods. We further determine the factors that govern ecosystem sensitivity to hydroclimatic extremes. We focus on Australia but extended our analyses to other global dryland regions due to their significant role in global biogeochemical cycles. Our results revealed dramatic impacts of drought and wet hydroclimatic extremes on ecosystem function, with abrupt changes in vegetation productivity, carbon uptake, and water-use-efficiency between years. Drought resulted in widespread reductions or collapse in the normal patterns of vegetation growth seasonality such that in many cases there was no detectable phenological cycle during extreme drought years. We further identified a significant increasing trend (p < 0.001) in extreme wet year precipitation amounts over Australia and many other global regions, resulting in an increasing trend in magnitude of the episodic carbon sink pulses coupled to each La Niña-induced wet years. This finding is of global biogeochemical significance, with the consequence of amplifying the global carbon cycle. Lastly, we use landscape measurements of carbon and water fluxes from eddy-covariance towers and field sampling of aboveground net primary productivity from long-term ecological networks to verify the patterns observed by top-down approaches. Our results demonstrate the intensification of hydroclimatic extremes due to global warming is exerting important impacts on ecosystem function, which further have significant implications on global biogeochemical cycles as well as local ecosystem processes.

Landscape dynamics in Mediterranean oak forests under global change: understanding the role of anthropogenic and environmental drivers across forest types.

PubMed

Acácio, Vanda; Dias, Filipe S; Catry, Filipe X; Rocha, Marta; Moreira, Francisco

2017-03-01

The Mediterranean region is projected to be extremely vulnerable to global change, which will affect the distribution of typical forest types such as native oak forests. However, our understanding of Mediterranean oak forest responses to future conditions is still very limited by the lack of knowledge on oak forest dynamics and species-specific responses to multiple drivers. We compared the long-term (1966-2006) forest persistence and land cover change among evergreen (cork oak and holm oak) and deciduous oak forests and evaluated the importance of anthropogenic and environmental drivers on observed changes for Portugal. We used National Forest Inventories to quantify the changes in oak forests and explored the drivers of change using multinomial logistic regression analysis and an information theoretical approach. We found distinct trends among oak forest types, reflecting the differences in oak economic value, protection status and management schemes: cork oak forests were the most persistent (62%), changing mostly to pines and eucalypt; holm oak forests were less persistent (53.2%), changing mostly to agriculture; and deciduous oak forests were the least persistent (45.7%), changing mostly to shrublands. Drivers of change had distinct importance across oak forest types, but drivers from anthropogenic origin (wildfires, population density, and land accessibility) were always among the most important. Climatic extremes were also important predictors of oak forest changes, namely extreme temperatures for evergreen oak forests and deficit of precipitation for deciduous oak forests. Our results indicate that under increasing human pressure and forecasted climate change, evergreen oak forests will continue declining and deciduous oak forests will be replaced by forests dominated by more xeric species. In the long run, multiple disturbances may change competitive dominance from oak forests to pyrophytic shrublands. A better understanding of forest dynamics and the inclusion of anthropogenic drivers on models of vegetation change will improve predicting the future of Mediterranean oak forests. © 2016 John Wiley & Sons Ltd.

Genetics of trehalose biosynthesis in desert-derived Aureobasidium melanogenum and role of trehalose in the adaptation of the yeast to extreme environments.

PubMed

Jiang, Hong; Liu, Guang-Lei; Chi, Zhe; Hu, Zhong; Chi, Zhen-Ming

2018-04-01

Melanin plays an important role in the stress adaptation of Aureobasidium melanogenum XJ5-1 isolated from the Taklimakan desert. A trehalose-6-phosphate synthase gene (TPS1 gene) was cloned from K5, characterized, and then deleted to determine the role of trehalose in the stress adaptation of the albino mutant K5. No stress response element and heat shock element were found in the promoter of the TPS1 gene. Deletion of the TPS1 gene in the albino mutant rendered a strain DT43 unable to synthesize any trehalose, but DT43 still could grow in glucose, suggesting that its hexokinase was insensitive to inhibition by trehalose-6-phosphate. Overexpression of the TPS1 gene enhanced trehalose biosynthesis in strain ET6. DT43 could not grow at 33 °C, whereas K5, ET6, and XJ5-1 could grow well at this temperature. Compared with K5 and ET6, DT43 was highly sensitive to heat shock treatment, high oxidation, and high desiccation, but all the three strains demonstrated the same sensitivity to UV light and high NaCl concentration. Therefore, trehalose played an important role in the adaptation of K5 to heat shock treatment, high oxidation, and high desiccation.

The role of ensemble post-processing for modeling the ensemble tail

NASA Astrophysics Data System (ADS)

Van De Vyver, Hans; Van Schaeybroeck, Bert; Vannitsem, Stéphane

2016-04-01

The past decades the numerical weather prediction community has witnessed a paradigm shift from deterministic to probabilistic forecast and state estimation (Buizza and Leutbecher, 2015; Buizza et al., 2008), in an attempt to quantify the uncertainties associated with initial-condition and model errors. An important benefit of a probabilistic framework is the improved prediction of extreme events. However, one may ask to what extent such model estimates contain information on the occurrence probability of extreme events and how this information can be optimally extracted. Different approaches have been proposed and applied on real-world systems which, based on extreme value theory, allow the estimation of extreme-event probabilities conditional on forecasts and state estimates (Ferro, 2007; Friederichs, 2010). Using ensemble predictions generated with a model of low dimensionality, a thorough investigation is presented quantifying the change of predictability of extreme events associated with ensemble post-processing and other influencing factors including the finite ensemble size, lead time and model assumption and the use of different covariates (ensemble mean, maximum, spread...) for modeling the tail distribution. Tail modeling is performed by deriving extreme-quantile estimates using peak-over-threshold representation (generalized Pareto distribution) or quantile regression. Common ensemble post-processing methods aim to improve mostly the ensemble mean and spread of a raw forecast (Van Schaeybroeck and Vannitsem, 2015). Conditional tail modeling, on the other hand, is a post-processing in itself, focusing on the tails only. Therefore, it is unclear how applying ensemble post-processing prior to conditional tail modeling impacts the skill of extreme-event predictions. This work is investigating this question in details. Buizza, Leutbecher, and Isaksen, 2008: Potential use of an ensemble of analyses in the ECMWF Ensemble Prediction System, Q. J. R. Meteorol. Soc. 134: 2051-2066.Buizza and Leutbecher, 2015: The forecast skill horizon, Q. J. R. Meteorol. Soc. 141: 3366-3382.Ferro, 2007: A probability model for verifying deterministic forecasts of extreme events. Weather and Forecasting 22 (5), 1089-1100.Friederichs, 2010: Statistical downscaling of extreme precipitation events using extreme value theory. Extremes 13, 109-132.Van Schaeybroeck and Vannitsem, 2015: Ensemble post-processing using member-by-member approaches: theoretical aspects. Q.J.R. Meteorol. Soc., 141: 807-818.

Extreme Rainfall from Hurricane Harvey (2017): Intercomparisons of WRF Simulations and Polarimetric Radar Fields

NASA Astrophysics Data System (ADS)

Yang, L.; Smith, J. A.; Liu, M.; Baeck, M. L.; Chaney, M. M.; Su, Y.

2017-12-01

Hurricane Harvey made landfall on 25 August 2017 and produced more than a meter of rain during a four-day period over eastern Texas, making it the wettest tropical cyclone on record in the United States. Extreme rainfall from Harvey was predominantly related to the dynamics and structure of outer rain bands. In this study, we provide details of the extreme rainfall produced by Hurricane Harvey. The principal research questions that motivate this study are: (1) what are the key microphysical properties of extreme rainfall from landfalling tropical cyclones and (2) what are the capabilities and deficiencies of existing bulk microphysics parameterizations from the physical models in capturing them. Our analyses are centered on intercomparisons of high-resolution simulations using the Weather Research and Forecasting (WRF) model and polarimetric radar fields from KHGX (Houston, Texas) WSR-88D. The WRF simulations accurately capture the track and intensity of Hurricane Harvey. Multi-rainband structure and its key evolution features are also well represented in the simulations. Two microphysics parameterizations (WSM6 and WDM6) are tested in this study. Radar reflectivity and differential reflectivity fields simulated by the WRF model are compared with polarimetric radar observations. An important feature for the extreme rainfall from Hurricane Harvey is the sharp boundary of spatial rainfall accumulation along the coast (with torrential rainfall distributed over Houston and its surrounding inland areas). We will examine the role of land-sea contrasts in dictating storm structure and evolution from both WRF simulations and polarimetric radar fields. Implications for improving hurricane rainfall forecasts and estimates will be provided.

Biogeophysical Impacts of Land-Use Change on Climate Extremes in Low-Emission Scenarios: Results From HAPPI-Land

NASA Astrophysics Data System (ADS)

Hirsch, Annette L.; Guillod, Benoit P.; Seneviratne, Sonia I.; Beyerle, Urs; Boysen, Lena R.; Brovkin, Victor; Davin, Edouard L.; Doelman, Jonathan C.; Kim, Hyungjun; Mitchell, Daniel M.; Nitta, Tomoko; Shiogama, Hideo; Sparrow, Sarah; Stehfest, Elke; van Vuuren, Detlef P.; Wilson, Simon

2018-03-01

The impacts of land use have been shown to have considerable influence on regional climate. With the recent international commitment to limit global warming to well below 2°C, emission reductions need to be ambitious and could involve major land-use change (LUC). Land-based mitigation efforts to curb emissions growth include increasing terrestrial carbon sequestration through reforestation, or the adoption of bioenergy crops. These activities influence local climate through biogeophysical feedbacks, however, it is uncertain how important they are for a 1.5° climate target. This was the motivation for HAPPI-Land: the half a degree additional warming, prognosis, and projected impacts—land-use scenario experiment. Using four Earth system models, we present the first multimodel results from HAPPI-Land and demonstrate the critical role of land use for understanding the characteristics of regional climate extremes in low-emission scenarios. In particular, our results show that changes in temperature extremes due to LUC are comparable in magnitude to changes arising from half a degree of global warming. We also demonstrate that LUC contributes to more than 20% of the change in temperature extremes for large land areas concentrated over the Northern Hemisphere. However, we also identify sources of uncertainty that influence the multimodel consensus of our results including how LUC is implemented and the corresponding biogeophysical feedbacks that perturb climate. Therefore, our results highlight the urgent need to resolve the challenges in implementing LUC across models to quantify the impacts and consider how LUC contributes to regional changes in extremes associated with sustainable development pathways.

Biogeophysical Impacts of Land‐Use Change on Climate Extremes in Low‐Emission Scenarios: Results From HAPPI‐Land

PubMed Central

Seneviratne, Sonia I.; Beyerle, Urs; Boysen, Lena R.; Brovkin, Victor; Davin, Edouard L.; Doelman, Jonathan C.; Kim, Hyungjun; Mitchell, Daniel M.; Nitta, Tomoko; Shiogama, Hideo; Sparrow, Sarah; Stehfest, Elke; van Vuuren, Detlef P.; Wilson, Simon

2018-01-01

Abstract The impacts of land use have been shown to have considerable influence on regional climate. With the recent international commitment to limit global warming to well below 2°C, emission reductions need to be ambitious and could involve major land‐use change (LUC). Land‐based mitigation efforts to curb emissions growth include increasing terrestrial carbon sequestration through reforestation, or the adoption of bioenergy crops. These activities influence local climate through biogeophysical feedbacks, however, it is uncertain how important they are for a 1.5° climate target. This was the motivation for HAPPI‐Land: the half a degree additional warming, prognosis, and projected impacts—land‐use scenario experiment. Using four Earth system models, we present the first multimodel results from HAPPI‐Land and demonstrate the critical role of land use for understanding the characteristics of regional climate extremes in low‐emission scenarios. In particular, our results show that changes in temperature extremes due to LUC are comparable in magnitude to changes arising from half a degree of global warming. We also demonstrate that LUC contributes to more than 20% of the change in temperature extremes for large land areas concentrated over the Northern Hemisphere. However, we also identify sources of uncertainty that influence the multimodel consensus of our results including how LUC is implemented and the corresponding biogeophysical feedbacks that perturb climate. Therefore, our results highlight the urgent need to resolve the challenges in implementing LUC across models to quantify the impacts and consider how LUC contributes to regional changes in extremes associated with sustainable development pathways.

Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis

PubMed Central

Wen, Luan; Fu, Liezhen; Guo, Xiaogang; Chen, Yonglong; Shi, Yun-Bo

2015-01-01

Histone methylations have been implicated to play important roles in diverse cellular processes. Of particular interest is the methylation of histone H3K79, which is catalyzed by an evolutionarily conserved methyltransferase, disruptor of telomeric silencing (Dot1)-like (Dot1L). To investigate the role of Dot1L during vertebrate development, we have generated a Dot1L-specific transcription activator-like effector nuclease (TALEN) nuclease to knockdown endogenous Dot1L in Xenopus tropicalis, a diploid species highly related to the well-known developmental model Xenopus laevis, a pseudotetraploid amphibian. We show that the TALEN was extremely efficient in mutating Dot1L when expressed in fertilized eggs, creating essentially Dot1L knockout embryos with little H3K79 methylation. Importantly, we observed that Dot1L knockdown had no apparent effect on embryogenesis because normally feeding tadpoles were formed, consistent with the lack of maternal Dot1L expression. On the other hand, Dot1L knockdown severely retarded the growth of the tadpoles and led to tadpole lethality prior to metamorphosis. These findings suggest that Dot1L and H3K79 methylation play an important role for tadpole growth and development prior to metamorphosis into a frog. Our findings further reveal interesting similarities and differences between Xenopus and mouse development and suggest the existence of 2 separate phases of vertebrate development with distinct requirements for epigenetic modifications.—Wen, L., Fu, L., Guo, X., Chen, Y., Shi, Y.-B. Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis. PMID:25366346

Archaeal Enzymes and Applications in Industrial Biocatalysts.

PubMed

Littlechild, Jennifer A

2015-01-01

Archaeal enzymes are playing an important role in industrial biotechnology. Many representatives of organisms living in "extreme" conditions, the so-called Extremophiles, belong to the archaeal kingdom of life. This paper will review studies carried by the Exeter group and others regarding archaeal enzymes that have important applications in commercial biocatalysis. Some of these biocatalysts are already being used in large scale industrial processes for the production of optically pure drug intermediates and amino acids and their analogues. Other enzymes have been characterised at laboratory scale regarding their substrate specificity and properties for potential industrial application. The increasing availability of DNA sequences from new archaeal species and metagenomes will provide a continuing resource to identify new enzymes of commercial interest using both bioinformatics and screening approaches.

A dependence modelling study of extreme rainfall in Madeira Island

NASA Astrophysics Data System (ADS)

Gouveia-Reis, Délia; Guerreiro Lopes, Luiz; Mendonça, Sandra

2016-08-01

The dependence between variables plays a central role in multivariate extremes. In this paper, spatial dependence of Madeira Island's rainfall data is addressed within an extreme value copula approach through an analysis of maximum annual data. The impact of altitude, slope orientation, distance between rain gauge stations and distance from the stations to the sea are investigated for two different periods of time. The results obtained highlight the influence of the island's complex topography on the spatial distribution of extreme rainfall in Madeira Island.

The importance of range edges for an irruptive species during extreme weather events

USGS Publications Warehouse

Bateman, Brooke L.; Pidgeon, Anna M.; Radeloff, Volker C.; Allstadt, Andrew J.; Akçakaya, H. Resit; Thogmartin, Wayne E.; Vavrus, Stephen J.; Heglund, Patricia J.

2015-01-01

In a changing climate where more frequent extreme weather may be more common, conservation strategies for weather-sensitive species may require consideration of habitat in the edges of species’ ranges, even though non-core areas may be unoccupied in ‘normal’ years. Our results highlight the conservation importance of range edges in providing refuge from extreme events, such as drought, and climate change.

Review of complex networks application in hydroclimatic extremes with an implementation to characterize spatio-temporal drought propagation in continental USA

NASA Astrophysics Data System (ADS)

Konapala, Goutam; Mishra, Ashok

2017-12-01

The quantification of spatio-temporal hydroclimatic extreme events is a key variable in water resources planning, disaster mitigation, and preparing climate resilient society. However, quantification of these extreme events has always been a great challenge, which is further compounded by climate variability and change. Recently complex network theory was applied in earth science community to investigate spatial connections among hydrologic fluxes (e.g., rainfall and streamflow) in water cycle. However, there are limited applications of complex network theory for investigating hydroclimatic extreme events. This article attempts to provide an overview of complex networks and extreme events, event synchronization method, construction of networks, their statistical significance and the associated network evaluation metrics. For illustration purpose, we apply the complex network approach to study the spatio-temporal evolution of droughts in Continental USA (CONUS). A different drought threshold leads to a new drought event as well as different socio-economic implications. Therefore, it would be interesting to explore the role of thresholds on spatio-temporal evolution of drought through network analysis. In this study, long term (1900-2016) Palmer drought severity index (PDSI) was selected for spatio-temporal drought analysis using three network-based metrics (i.e., strength, direction and distance). The results indicate that the drought events propagate differently at different thresholds associated with initiation of drought events. The direction metrics indicated that onset of mild drought events usually propagate in a more spatially clustered and uniform approach compared to onsets of moderate droughts. The distance metric shows that the drought events propagate for longer distance in western part compared to eastern part of CONUS. We believe that the network-aided metrics utilized in this study can be an important tool in advancing our knowledge on drought propagation as well as other hydroclimatic extreme events. Although the propagation of droughts is investigated using the network approach, however process (physics) based approaches is essential to further understand the dynamics of hydroclimatic extreme events.

Impact of Extreme Climatic Events on the Temperature Regimes in Urban Streams

NASA Astrophysics Data System (ADS)

Parchem, C.; Stewart, I. T.

2016-12-01

Urban streams provide important aquatic and riparian habitat close to population centers, as well as other ecosystem services such as flood protection, storm water drainage and recreational functions. Yet, they are already greatly impacted by human action through water management, channel modifications, destruction of riparian habitat, and pollution. This has potentially rendered them more vulnerable to the climatic extremes projected from climatic changes. From 2012 - 2016, California has experienced to date the most severe drought since the beginning of weather recordings. The combination of the resulting extremely low stream flows exacerbated by low precipitation, high evaporation rates, and greater human demand on water, with high temperature have increased the temperature regime in urban streams. However, the extent to which urban stream temperatures are impacted by extreme climatic conditions and what role stream morphology, stream flow characteristics, and riparian vegetation play, are not sufficiently understood. For this project, we monitored stream temperature, dissolved oxygen, and flow depth along a network of 18 sites in the Los Gatos Creek, Guadalupe River, and Coyote Creek, located in the urban regions of the southern San Francisco Bay Area. Monitoring sites were distributed from stream headwaters to flood plains and represented a variety of stream environments. We examined the variation in stream temperature and dissolved oxygen with extreme air temperature, extremely low flow conditions, riparian shading, and channel morphology. Our results show that during the recent drought, hourly stream temperatures rose up to 34°C during summer heat waves for sites in the lower stream reaches without riparian shading. By contrast, shaded sites with deeper flows, and minimally affected by water management were able to maintain lower temperatures by several degrees. Understanding the conditions driving the response of urban streams to climatic extremes can aid in the protection of aquatic ecosystems under climatic change.

Mechanisms of food processing and storage-related stress tolerance in Clostridium botulinum.

PubMed

Dahlsten, Elias; Lindström, Miia; Korkeala, Hannu

2015-05-01

Vegetative cultures of Clostridium botulinum produce the extremely potent botulinum neurotoxin, and may jeopardize the safety of foods unless sufficient measures to prevent growth are applied. Minimal food processing relies on combinations of mild treatments, primarily to avoid deterioration of the sensory qualities of the food. Tolerance of C. botulinum to minimal food processing is well characterized. However, data on effects of successive treatments on robustness towards further processing is lacking. Developments in genetic manipulation tools and the availability of annotated genomes have allowed identification of genetic mechanisms involved in stress tolerance of C. botulinum. Most studies focused on low temperature, and the importance of various regulatory mechanisms in cold tolerance of C. botulinum has been demonstrated. Furthermore, novel roles in cold tolerance were shown for metabolic pathways under the control of these regulators. A role for secondary oxidative stress in tolerance to extreme temperatures has been proposed. Additionally, genetic mechanisms related to tolerance to heat, low pH, and high salinity have been characterized. Data on genetic stress-related mechanisms of psychrotrophic Group II C. botulinum strains are scarce; these mechanisms are of interest for food safety research and should thus be investigated. This minireview encompasses the importance of C. botulinum as a food safety hazard and its central physiological characteristics related to food-processing and storage-related stress. Special attention is given to recent findings considering genetic mechanisms C. botulinum utilizes in detecting and countering these adverse conditions. Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Analysis of genomic rearrangements, horizontal gene transfer and role of plasmids in the evolution of industrial important Thermus species.

PubMed

Kumwenda, Benjamin; Litthauer, Derek; Reva, Oleg

2014-09-25

Bacteria of genus Thermus inhabit both man-made and natural thermal environments. Several Thermus species have shown biotechnological potential such as reduction of heavy metals which is essential for eradication of heavy metal pollution; removing of organic contaminants in water; opening clogged pipes, controlling global warming among many others. Enzymes from thermophilic bacteria have exhibited higher activity and stability than synthetic or enzymes from mesophilic organisms. Using Meiothermus silvanus DSM 9946 as a reference genome, high level of coordinated rearrangements has been observed in extremely thermophilic Thermus that may imply existence of yet unknown evolutionary forces controlling adaptive re-organization of whole genomes of thermo-extremophiles. However, no remarkable differences were observed across species on distribution of functionally related genes on the chromosome suggesting constraints imposed by metabolic networks. The metabolic network exhibit evolutionary pressures similar to levels of rearrangements as measured by the cross-clustering index. Using stratigraphic analysis of donor-recipient, intensive gene exchanges were observed from Meiothermus species and some unknown sources to Thermus species confirming a well established DNA uptake mechanism as previously proposed. Global genome rearrangements were found to play an important role in the evolution of Thermus bacteria at both genomic and metabolic network levels. Relatively higher level of rearrangements was observed in extremely thermophilic Thermus strains in comparison to the thermo-tolerant Thermus scotoductus. Rearrangements did not significantly disrupt operons and functionally related genes. Thermus species appeared to have a developed capability for acquiring DNA through horizontal gene transfer as shown by the donor-recipient stratigraphic analysis.

Prandtl-number Effects in High-Rayleigh-number Spherical Convection

NASA Astrophysics Data System (ADS)

Orvedahl, Ryan J.; Calkins, Michael A.; Featherstone, Nicholas A.; Hindman, Bradley W.

2018-03-01

Convection is the predominant mechanism by which energy and angular momentum are transported in the outer portion of the Sun. The resulting overturning motions are also the primary energy source for the solar magnetic field. An accurate solar dynamo model therefore requires a complete description of the convective motions, but these motions remain poorly understood. Studying stellar convection numerically remains challenging; it occurs within a parameter regime that is extreme by computational standards. The fluid properties of the convection zone are characterized in part by the Prandtl number \\Pr = ν/κ, where ν is the kinematic viscosity and κ is the thermal diffusion; in stars, \\Pr is extremely low, \\Pr ≈ 10‑7. The influence of \\Pr on the convective motions at the heart of the dynamo is not well understood since most numerical studies are limited to using \\Pr ≈ 1. We systematically vary \\Pr and the degree of thermal forcing, characterized through a Rayleigh number, to explore its influence on the convective dynamics. For sufficiently large thermal driving, the simulations reach a so-called convective free-fall state where diffusion no longer plays an important role in the interior dynamics. Simulations with a lower \\Pr generate faster convective flows and broader ranges of scales for equivalent levels of thermal forcing. Characteristics of the spectral distribution of the velocity remain largely insensitive to changes in \\Pr . Importantly, we find that \\Pr plays a key role in determining when the free-fall regime is reached by controlling the thickness of the thermal boundary layer.

Optimizing rehabilitation for adults with visual impairment: attention to life goals and their links to well-being.

PubMed

Boerner, Kathrin; Cimarolli, Verena R

2005-10-01

To examine the importance of different life goals among working-age adults with vision impairment, the extent to which vision impairment interfered with goals, and how rehabilitation addressed these life goals. Cross-sectional descriptive study. Vision rehabilitation agency. Working-age adults with visual impairment. Telephone interviews using structured and open-ended assessments of life goal importance, goal interference due to vision loss, the role of goals in rehabilitation, and indicators of well-being. Eighty-six people participated. The life domains most frequently rated as extremely important were finances (60), residential and domestic arrangements (55), family (51), partner (48), and personal care (48). The extent to which vision loss interferes with these life goals was extreme for finances (46), residential and domestic arrangements (36), partner (27), family (25), and personal care (14). A life goal was addressed in rehabilitation: residential/domestic arrangements (41), work (39), finances (31), leisure/hobbies (28), personal care (24), family (17), partner (16), friends (10), and religion/life philosophy (8). Reports of a life goal being addressed in ineffective ways emerged for functional life goals, but not for relationship and religion/life philosophy goals. Goal interference was significantly correlated with well-being indicators across life domains. In contrast only partner and family relationship importance were significantly linked with well-being indicators. Relationship-related goals were a top priority for this study population, but functional compared to relationship goals were more commonly addressed in vision rehabilitation services.

Thinning of heterogeneous lithosphere: insights from field observations and numerical modelling

NASA Astrophysics Data System (ADS)

Petri, B.; Duretz, T.; Mohn, G.; Schmalholz, S. M.

2017-12-01

The nature and mechanisms of formation of extremely thinned continental crust (< 10 km) and lithosphere during rifting remain debated. Observations from present-day and fossil continental passive margins document the heterogeneous nature of the lithosphere characterized, among others, by lithological variations and structural inheritance. This contribution aims at investigating the mechanisms of extreme lithospheric thinning by exploring in particular the role of initial heterogeneities by coupling field observations from fossil passive margins and numerical models of lithospheric extension. Two field examples from the Alpine Tethys margins outcropping in the Eastern Alps (E Switzerland and N Italy) and in the Southern Alps (N Italy) were selected for their exceptional level of preservation of rift-related structures. This situation enables us to characterize (1) the pre-rift architecture of the continental lithosphere, (2) the localization of rift-related deformation in distinct portion of the lithosphere and (3) the interaction between initial heterogeneities of the lithosphere and rift-related structures. In a second stage, these observations are integrated in high-resolution, two-dimensional thermo-mechanical models taking into account various patterns of initial mechanical heterogeneities. Our results show the importance of initial pre-rift architecture of the continental lithosphere during rifting. Key roles are given to high-angle and low-angle normal faults, anastomosing shear-zones and decoupling horizons. We propose that during the first stages of thinning, deformation is strongly controlled by the complex pre-rift architecture of the lithosphere, localized along major structures responsible for the lateral extrusion of mid to lower crustal levels. This extrusion juxtaposes mechanically stronger levels in the hyper-thinned continental crust, being exhumed by subsequent low-angle normal faults. Altogether, these results highlight the critical role of the extraction of mechanically strong layers of the lithosphere during the extreme thinning of the continental lithosphere and allows to propose a new model for the formation of continental passive margins.

Modeling market mechanism with the minority game

NASA Astrophysics Data System (ADS)

Challet, Damien; Marsili, Matteo; Zhang, Yi-Cheng

2000-01-01

Using the minority game model we study a broad spectrum of problems of market mechanism. We study the role of different types of agents: producers, speculators as well as noise traders. The central issue here is the information flow: producers feed in the information whereas speculators make it away. How well each agent fares in the common game depends on the market conditions, as well as their sophistication. Sometimes there is much to gain with little effort, sometimes great effort virtually brings no more incremental gain. Market impact is also shown to play an important role, a strategy should be judged when it is actually used in play for its quality. Though the minority game is an extremely simplified market model, it allows to ask, analyze and answer many questions which arise in real markets.

Carbohydrate metabolism genes and pathways in insects: insights from the honey bee genome

PubMed Central

Kunieda, T; Fujiyuki, T; Kucharski, R; Foret, S; Ament, S A; Toth, A L; Ohashi, K; Takeuchi, H; Kamikouchi, A; Kage, E; Morioka, M; Beye, M; Kubo, T; Robinson, G E; Maleszka, R

2006-01-01

Carbohydrate-metabolizing enzymes may have particularly interesting roles in the honey bee, Apis mellifera, because this social insect has an extremely carbohydrate-rich diet, and nutrition plays important roles in caste determination and socially mediated behavioural plasticity. We annotated a total of 174 genes encoding carbohydrate-metabolizing enzymes and 28 genes encoding lipid-metabolizing enzymes, based on orthology to their counterparts in the fly, Drosophila melanogaster, and the mosquito, Anopheles gambiae. We found that the number of genes for carbohydrate metabolism appears to be more evolutionarily labile than for lipid metabolism. In particular, we identified striking changes in gene number or genomic organization for genes encoding glycolytic enzymes, cellulase, glucose oxidase and glucose dehydrogenases, glucose-methanol-choline (GMC) oxidoreductases, fucosyltransferases, and lysozymes. PMID:17069632

Significance of vapor phase chemical reactions on CVD rates predicted by chemically frozen and local thermochemical equilibrium boundary layer theories

NASA Technical Reports Server (NTRS)

Gokoglu, Suleyman A.

1988-01-01

This paper investigates the role played by vapor-phase chemical reactions on CVD rates by comparing the results of two extreme theories developed to predict CVD mass transport rates in the absence of interfacial kinetic barrier: one based on chemically frozen boundary layer and the other based on local thermochemical equilibrium. Both theories consider laminar convective-diffusion boundary layers at high Reynolds numbers and include thermal (Soret) diffusion and variable property effects. As an example, Na2SO4 deposition was studied. It was found that gas phase reactions have no important role on Na2SO4 deposition rates and on the predictions of the theories. The implications of the predictions of the two theories to other CVD systems are discussed.

Modeling and Deorphanization of Orphan GPCRs.

PubMed

Diaz, Constantino; Angelloz-Nicoud, Patricia; Pihan, Emilie

2018-01-01

Despite tremendous efforts, approximately 120 GPCRs remain orphan. Their physiological functions and their potential roles in diseases are poorly understood. Orphan GPCRs are extremely important because they may provide novel therapeutic targets for unmet medical needs. As a complement to experimental approaches, molecular modeling and virtual screening are efficient techniques to discover synthetic surrogate ligands which can help to elucidate the role of oGPCRs. Constitutively activated mutants and recently published active structures of GPCRs provide stimulating opportunities for building active molecular models for oGPCRs and identifying activators using virtual screening of compound libraries. We describe the molecular modeling and virtual screening process we have applied in the discovery of surrogate ligands, and provide examples for CCKA, a simulated oGPCR, and for two oGPCRs, GPR52 and GPR34.

The anthropogenic influence on heat and humidity in the US Midwest

NASA Astrophysics Data System (ADS)

Inda Diaz, H. A.; O'Brien, T. A.; Stone, D. A.

2016-12-01

Heatwaves, and extreme temperatures in general, have a wide range of negative impacts on society, and particularly on human health. In addition to temperature, humidity plays a key role in regulating human body temperature, with higher humidities tending to reduce the effectiveness of perspiration. There is recent theoretical and observational evidence that co-occurring extreme heat and humidity can potentially have a much more dramatic impact on human health than either extreme in isolation. There is an abundance of observational evidence indicating that anthropogenic increases in greenhouse gas (GHG) forcing have contributed to an increase in the intensity and frequency of temperature extremes on a global scale. However, aside from purely thermodynamically-driven increases in near-surface humidity, there is a paucity of similar evidence for anthropogenic impacts on humidity. Thermodynamic scaling would suggest that air masses originating from the ocean would be associated with higher specific humidity in a warmer world, and transpiration from irrigated crops could further increase humidity in warm air masses. In order to explore the role of anthropogenic GHG forcing on the co-occurrence of temperature and humidity extremes in the Midwestern United States (US), we evaluate a large ensemble of global climate model simulations with and without anthropogenic GHG forcing. In particular, we examine differences between the probability distributions of near-surface temperature, humidity, wet-bulb temperature, and the joint distribution of temperature and humidity in this ensemble. Finally, we explore augmenting this experimental framework with additional simulations to explore the role of anthropogenic changes in the land surface, and in particular irrigated crops, on co-occurring extreme heat and humidity.

Causing Factors for Extreme Precipitation in the Western Saudi-Arabian Peninsula

NASA Astrophysics Data System (ADS)

Alharbi, M. M.; Leckebusch, G. C.

2015-12-01

In the western coast of Saudi Arabia the climate is in general semi-arid but extreme precipitation events occur on a regular basis: e.g., on 26th November 2009, when 122 people were killed and 350 reported missing in Jeddah following more than 90mm in just four hours. Our investigation will a) analyse major drivers of the generation of extremes and b) investigate major responsible modes of variability for the occurrence of extremes. Firstly, we present a systematic analysis of station based observations of the most relevant extreme events (1985-2013) for 5 stations (Gizan, Makkah, Jeddah, Yenbo and Wejh). Secondly, we investigate the responsible mechanism on the synoptic to large-scale leading to the generation of extremes and will analyse factors for the time variability of extreme event occurrence. Extreme events for each station are identified in the wet season (Nov-Jan): 122 events show intensity above the respective 90th percentile. The most extreme events are systematically investigated with respect to the responsible forcing conditions which we can identify as: The influence of the Soudan Low, active Red-Sea-Trough situations established via interactions with mid-latitude tropospheric wave activity, low pressure systems over the Mediterranean, the influence of the North Africa High, the Arabian Anticyclone and the influence of the Indian monsoon trough. We investigate the role of dynamical forcing factors like the STJ and the upper-troposphere geopotential conditions and the relation to smaller local low-pressure systems. By means of an empirical orthogonal function (EOF) analysis based on MSLP we investigate the possibility to objectively quantify the influence of existing major variability modes and their role for the generation of extreme precipitation events.

Thermospheric Nitric Oxide Response to Shock-led Storms

PubMed Central

Knipp, D. J.; Pette, D. V.; Kilcommons, L. M.; Isaacs, T. L.; Cruz, A. A.; Mlynczak, M. G.; Hunt, L. A.; Lin, C. Y.

2017-01-01

We present a multi-year superposed epoch study of the Sounding of the Atmosphere using Broadband Emission Radiometry nitric oxide (NO) emission data. NO is a trace constituent in the thermosphere that acts as cooling agent via infrared (IR) emissions. The NO cooling competes with storm time thermospheric heating resulting in a thermostat effect. Our study of nearly 200 events reveals that shock-led interplanetary coronal mass ejections (ICMEs) are prone to early and excessive thermospheric NO production and IR emissions. Excess NO emissions can arrest thermospheric expansion by cooling the thermosphere during intense storms. The strongest events curtail the interval of neutral density increase and produce a phenomenon known as thermospheric ‘overcooling’. We use Defense Meteorological Satellite Program particle precipitation data to show that interplanetary shocks and their ICME drivers can more than double the fluxes of precipitating particles that are known to trigger the production of thermospheric NO. Coincident increases in Joule heating likely amplify the effect. In turn, NO emissions more than double. We discuss the roles and features of shock/sheath structures that allow the thermosphere to temper the effects of extreme storm time energy input and explore the implication these structures may have on mesospheric NO. Shock-driven thermospheric NO IR cooling likely plays an important role in satellite drag forecasting challenges during extreme events. PMID:28824340

Thermospheric Nitric Oxide Response to Shock-led Storms.

PubMed

Knipp, D J; Pette, D V; Kilcommons, L M; Isaacs, T L; Cruz, A A; Mlynczak, M G; Hunt, L A; Lin, C Y

2017-02-01

We present a multi-year superposed epoch study of the Sounding of the Atmosphere using Broadband Emission Radiometry nitric oxide (NO) emission data. NO is a trace constituent in the thermosphere that acts as cooling agent via infrared (IR) emissions. The NO cooling competes with storm time thermospheric heating resulting in a thermostat effect. Our study of nearly 200 events reveals that shock-led interplanetary coronal mass ejections (ICMEs) are prone to early and excessive thermospheric NO production and IR emissions. Excess NO emissions can arrest thermospheric expansion by cooling the thermosphere during intense storms. The strongest events curtail the interval of neutral density increase and produce a phenomenon known as thermospheric 'overcooling'. We use Defense Meteorological Satellite Program particle precipitation data to show that interplanetary shocks and their ICME drivers can more than double the fluxes of precipitating particles that are known to trigger the production of thermospheric NO. Coincident increases in Joule heating likely amplify the effect. In turn, NO emissions more than double. We discuss the roles and features of shock/sheath structures that allow the thermosphere to temper the effects of extreme storm time energy input and explore the implication these structures may have on mesospheric NO. Shock-driven thermospheric NO IR cooling likely plays an important role in satellite drag forecasting challenges during extreme events.

Narcissism as a moderator of satisfaction with body image in young women with extreme underweight and obesity.

PubMed

Lipowska, Małgorzata; Lipowski, Mariusz

2015-01-01

Body weight and age constitute main determinants of body image in women. We analyzed the role of narcissism as a moderator of body image in young women representing various extremes of body weight. The study included 325 women between 18 and 35 years, qualified into three BMI categories: obese women (BMI > 30.0, n = 72), severely underweight women who did not satisfy the remaining criteria of anorexia (BMI < 17.5, n = 85), and women with normal body weight (21.7 < "ideal BMI" > 22.7, n = 168). Satisfaction with body image was determined with Multidimensional Body-Self Relations Questionnaire and Body Esteem Scale, while narcissism was measured with Narcissistic Personality Inventory. We revealed that narcissism has significant impact on the body image of women who are extremely underweight or obese. Vanity and Leadership were narcissism dimensions which played significant role in slim women, as compared to Vanity and Self-Sufficiency in obese women. The role of narcissism as a modulator of self-satisfaction with one's body varies depending on BMI level: extremely underweight women and obese individuals constitute groups in which narcissism has the strongest impact on the self-satisfaction with body.

Estimating the Effect of Climate Change on Crop Yields and Farmland Values: The Importance of Extreme Temperatures

EPA Pesticide Factsheets

This is a presentation titled Estimating the Effect of Climate Change on Crop Yields and Farmland Values: The Importance of Extreme Temperatures that was given for the National Center for Environmental Economics

SWH trends and links to large scale teleconnection patterns in the Mediterranean Sea

NASA Astrophysics Data System (ADS)

Lionello, P.; Pino, C.; Galati, M. B.

2010-09-01

This study analyzes the SWH field in the Mediterranean Sea using a multidecadal simulations (1958-2001) carried out using the WAM (WAve Model) forced by the REMO-HIPOCAS wind fields. The simulations are validated against satellite altimeter data. Several mid-latitude patterns are linked to the SWH field in the Mediterranean. Considering the mean monthly SWH values, EA (Eastern Atlantic pattern) exerts the largest influence, while NAO and other patterns have a smaller but comparable effect. Severe SWH conditions have been characterized using the 95percentile of daily SWH maxima. NAO is important mainly for high SWH conditions in winter with significant correlation in December, January and March, but also EA, SCA (SCAndinavian) and EA-WR (Eastern Atlantic-Western Russia) play an important role. In general, both SWH high and mean values are modulated by several patterns, with an important variability in space and at monthly level so that no single pattern can be attributed a dominant role along the whole annual cycle and all the mentioned patterns are important for at least few months in the year. Significant trends of SWH are present only in sparse areas and suggest mostly a minor decrease of storm intensity, The statistics of extremes and high SWH values is substantially steady during the second half of the 20th century.

The Photographic History of Greenland's Glaciers - and how the historical data plays an important role in today's glacier research

NASA Astrophysics Data System (ADS)

Bjork, A. A.; Kjeldsen, K. K.; Korsgaard, N. J.; Aagaard, S.; Andresen, C. S.; Bamber, J. L.; van den Broeke, M.; Colgan, W. T.; Funder, S.; Khan, S. A.; Larsen, N. K.; Machguth, H.; Nuth, C.; Schomacker, A.; Kjaer, K. H.

2015-12-01

As the Greenland Ice Sheet and Greenland's glaciers are continuing to loss mass at high rates, knowledge of their past response to climatic changes is ever important. By harvesting the archives for images, both terrestrial and airborne, we are able to expand the record of glacier observation by several decades, thus supplying crucial knowledge on glacier behavior to important climatic transitions such as the end of the Little Ice Age and the early 20th Century warming. Here we show how a large collection of historical aerial images portray the glacial response to the Little Ice Age deglaciation in Greenland and document frontal change throughout the 20th Century. A detailed story of the LIA-deglaciation is told by supplementing with terrestrial photos that capture the onset of retreat and high resolution aerial images that portray geomorphological evidence of the Little Ice Age maximum extent. This work is the result of several generations of Greenland researches and their efforts to portray and document the state of the glaciers, and highlights that while interpretations and conclusions may be challenged and changed through time, the raw observations remain extremely valuable. Finally, we also show how archival data besides photos may play an important role in future glacier research in Greenland.

Mind over platter: pre-meal planning and the control of meal size in humans.

PubMed

Brunstrom, J M

2014-07-01

It is widely accepted that meal size is governed by psychological and physiological processes that generate fullness towards the end of a meal. However, observations of natural eating behaviour suggest that this preoccupation with within-meal events may be misplaced and that the role of immediate post-ingestive feedback (for example, gastric stretch) has been overstated. This review considers the proposition that the locus of control is more likely to be expressed in decisions about portion size, before a meal begins. Consistent with this idea, we have discovered that people are extremely adept at estimating the 'expected satiety' and 'expected satiation' of different foods. These expectations are learned over time and they are highly correlated with the number of calories that end up on our plate. Indeed, across a range of foods, the large variation in expected satiety/satiation may be a more important determinant of meal size than relatively subtle differences in palatability. Building on related advances, it would also appear that memory for portion size has an important role in generating satiety after a meal has been consumed. Together, these findings expose the importance of planning and episodic memory in the control of appetite and food intake in humans.

The UK water crisis: What actions the government and private sector need to take.

PubMed

Skelton, Emmeline

2015-01-01

The paper discusses why resilience is increasingly important for companies to measure and address, thinking about relevant issues such as climate change and extreme weather. It gives insight on how companies measure their resilience and that it is more than a business continuity issue; indeed, it is a board issue. The paper looks at the role of regulation for companies with national critical infrastructure in putting in resilience guidelines and discusses the benefits of regulation in resilience, presenting a case study of the UK Water Services Regulation Authority resilience guidelines.

Social Case-work in General Practice: An Alternative Approach

PubMed Central

Ratoff, L.; Pearson, Barbara

1970-01-01

During a two-year period a senior case-worker was seconded by a voluntary family case-work agency, the Liverpool Personal Service Society, to work with three general practitioners. The commonest reasons for referral of the 157 new patients to the social worker over this study period were extreme poverty; housing, matrimonial, and psychiatric problems; and problems of fatherless families. The successful and valuable co-operation between the general practitioners, case-worker, and various specialist professional and financial services of the Society have proved that a professional social worker has an important role in the general-practice team. PMID:5420213

An Adult Case of Recurrent Guillain-Barré Syndrome with Anti-galactocerebroside Antibodies

PubMed Central

Takahashi, Hisashi; Kimura, Tadashi; Yuki, Natsuko; Yoshioka, Akira

2017-01-01

A 79-year-old woman with a history of Guillain-Barré syndrome (GBS) developed somnolence and tetraparesis after pneumonia. Based on clinical and laboratory findings, she was diagnosed with complications of acute inflammatory demyelinating polyneuropathy (AIDP) and acute disseminated encephalomyelitis (ADEM). Anti-galactocerebroside (Gal-C) IgG antibodies were detected in her serum. Cases of recurrent GBS in patients who are positive for this antibody are extremely rare. The anti-Gal-C IgG antibodies likely played an important role in the pathogenesis of the AIDP and ADEM. PMID:29093388

Inflight thermodynamic properties

NASA Technical Reports Server (NTRS)

Brown, S. C.; Daniels, G. E.; Johnson, D. L.; Smith, O. E.

1973-01-01

The inflight thermodynamic parameters (temperature, pressure, and density) of the atmosphere are presented. Mean and extreme values of the thermodynamic parameters given here can be used in application of many aerospace problems, such as: (1) research and planning and engineering design of remote earth sensing systems; (2) vehicle design and development; and (3) vehicle trajectory analysis, dealing with vehicle thrust, dynamic pressure, aerodynamic drag, aerodynamic heating, vibration, structural and guidance limitations, and reentry analysis. Atmospheric density plays a very important role in most of the above problems. A subsection on reentry is presented, giving atmospheric models to be used for reentry heating, trajectory, etc., analysis.

Understanding the Role of Air-Sea Interaction on Extreme Rainfall in Aquaplanet and Earth-like CESM2

NASA Astrophysics Data System (ADS)

Benedict, J. J.; Clement, A. C.; Medeiros, B.

2017-12-01

Extreme precipitation events are associated with anomalous, latitudinally dependent dynamical and convective weather systems. For example, plumes of excessive poleward water vapor transport and topographical effects drive extreme precipitation events in the midlatitudes, while intense tropical precipitation is associated with organized convective systems. In both cases, air-sea fluxes have the potential to contribute significantly to the moisture budget of these storms, but the roles of surface fluxes and upper-ocean processes and their impact on precipitation extremes have yet to be explored in sufficient detail. To examine such mechanisms, we implement a climate model hierarchy that encompasses a spectrum of ocean models, from prescribed-SST to fully dynamic, as well as both aquaplanet and Earth-like lower boundary types within version 2 of the Community Earth System Model (CESM2). Using the CESM2 hierarchy and comparing to observations, we identify key moisture processes and related air-sea interactions that drive extreme precipitation events across different latitudes in Earth-like models and then generalize the analyses in aquaplanet configurations to highlight the most salient features. The analyses are applied to both present-day and global warming conditions to investigate how these fundamental mechanisms might change extreme precipitation events in the future climate.

The materials processing research base of the Materials Processing Center. Report for FY 1982

NASA Technical Reports Server (NTRS)

Flemings, M. C.

1983-01-01

The work described, while involving research in the broad field of materials processing, has two common features: the problems are closed related to space precessing of materials and have both practical and fundamental significance. An interesting and important feature of many of the projects is that the interdisciplinary nature of the problem mandates complementary analytical modeling/experimental approaches. An other important aspect of many of the projects is the increasing use of mathematical modeling techniques as one of the research tools. The predictive capability of these models, when tested against measurements, plays a very important role in both the planning of experimental programs and in the rational interpretation of the results. Many of the projects described have a space experiment as their ultimate objective. Mathematical models are proving to be extremely valuable in projecting the findings of ground - based experiments to microgravity conditions.

Structure and functioning of dryland ecosystems in a changing world.

PubMed

Maestre, Fernando T; Eldridge, David J; Soliveres, Santiago; Kéfi, Sonia; Delgado-Baquerizo, Manuel; Bowker, Matthew A; García-Palacios, Pablo; Gaitán, Juan; Gallardo, Antonio; Lázaro, Roberto; Berdugo, Miguel

2016-11-01

Understanding how drylands respond to ongoing environmental change is extremely important for global sustainability. Here we review how biotic attributes, climate, grazing pressure, land cover change and nitrogen deposition affect the functioning of drylands at multiple spatial scales. Our synthesis highlights the importance of biotic attributes (e.g. species richness) in maintaining fundamental ecosystem processes such as primary productivity, illustrate how N deposition and grazing pressure are impacting ecosystem functioning in drylands worldwide, and highlight the importance of the traits of woody species as drivers of their expansion in former grasslands. We also emphasize the role of attributes such as species richness and abundance in controlling the responses of ecosystem functioning to climate change. This knowledge is essential to guide conservation and restoration efforts in drylands, as biotic attributes can be actively managed at the local scale to increase ecosystem resilience to global change.

Structure and functioning of dryland ecosystems in a changing world

PubMed Central

Maestre, Fernando T.; Eldridge, David J.; Soliveres, Santiago; Kéfi, Sonia; Delgado-Baquerizo, Manuel; Bowker, Matthew A.; García-Palacios, Pablo; Gaitán, Juan; Gallardo, Antonio; Lázaro, Roberto; Berdugo, Miguel

2017-01-01

Understanding how drylands respond to ongoing environmental change is extremely important for global sustainability. Here we review how biotic attributes, climate, grazing pressure, land cover change and nitrogen deposition affect the functioning of drylands at multiple spatial scales. Our synthesis highlights the importance of biotic attributes (e.g. species richness) in maintaining fundamental ecosystem processes such as primary productivity, illustrate how N deposition and grazing pressure are impacting ecosystem functioning in drylands worldwide, and highlight the importance of the traits of woody species as drivers of their expansion in former grasslands. We also emphasize the role of attributes such as species richness and abundance in controlling the responses of ecosystem functioning to climate change. This knowledge is essential to guide conservation and restoration efforts in drylands, as biotic attributes can be actively managed at the local scale to increase ecosystem resilience to global change. PMID:28239303

[Aggressive and prosocial behavior in childhood psychopathology].

PubMed

Vida, Péter; Halász, József; Gádoros, Júlia

2013-01-01

Aggressive/attacking and helpful/emphatic/prosocial behaviors are extremely important in human relationships. Both high levels of aggression and deficits of prosociality play important role in the development and conservation of mental disorders. We review the measurement options and clinical importance of aggressive and prosocial behavior. The typical developmental pathways and the genetic and environmental background of these behaviors are presented. The clinical tools used in the measurement of aggression and prosociality are summarized in the present paper, with specific attention on questionnaires applied in Hungarian practice. The connections between diagnostic categories (conduct disorder, oppositional-defiant disorder, attention deficit and hyperactive disorder, autism spectrum disorders) and the two behaviors are evaluated. In the end, we present those additional research projects that explore the cognitive-emotional background of aggressive or prosocial behavior with clinical relevance either in the diagnosis or in the treatment of child psychiatric diseases.

The relative importance among anthropogenic forcings of land use/land cover change in affecting temperature extremes

NASA Astrophysics Data System (ADS)

Chen, Liang; Dirmeyer, Paul A.

2018-05-01

Land use/land cover change (LULCC) exerts significant influence on regional climate extremes, but its relative importance compared with other anthropogenic climate forcings has not been thoroughly investigated. This study compares land use forcing with other forcing agents in explaining the simulated historical temperature extreme changes since preindustrial times in the CESM-Last Millennium Ensemble (LME) project. CESM-LME suggests that the land use forcing has caused an overall cooling in both warm and cold extremes, and has significantly decreased diurnal temperature range (DTR). Due to the competing effects of the GHG and aerosol forcings, the spatial pattern of changes in 1850-2005 climatology of temperature extremes in CESM-LME can be largely explained by the land use forcing, especially for hot extremes and DTR. The dominance of land use forcing is particularly evident over Europe, eastern China, and the central and eastern US. Temporally, the land-use cooling is relatively stable throughout the historical period, while the warming of temperature extremes is mainly influenced by the enhanced GHG forcing, which has gradually dampened the local dominance of the land use effects. Results from the suite of CMIP5 experiments partially agree with the local dominance of the land use forcing in CESM-LME, but inter-model discrepancies exist in the distribution and sign of the LULCC-induced temperature changes. Our results underline the overall importance of LULCC in historical temperature extreme changes, implying land use forcing should be highlighted in future climate projections.

Uncertainty Modeling for Robustness Analysis of Control Upset Prevention and Recovery Systems

NASA Technical Reports Server (NTRS)

Belcastro, Christine M.; Khong, Thuan H.; Shin, Jong-Yeob; Kwatny, Harry; Chang, Bor-Chin; Balas, Gary J.

2005-01-01

Formal robustness analysis of aircraft control upset prevention and recovery systems could play an important role in their validation and ultimate certification. Such systems (developed for failure detection, identification, and reconfiguration, as well as upset recovery) need to be evaluated over broad regions of the flight envelope and under extreme flight conditions, and should include various sources of uncertainty. However, formulation of linear fractional transformation (LFT) models for representing system uncertainty can be very difficult for complex parameter-dependent systems. This paper describes a preliminary LFT modeling software tool which uses a matrix-based computational approach that can be directly applied to parametric uncertainty problems involving multivariate matrix polynomial dependencies. Several examples are presented (including an F-16 at an extreme flight condition, a missile model, and a generic example with numerous crossproduct terms), and comparisons are given with other LFT modeling tools that are currently available. The LFT modeling method and preliminary software tool presented in this paper are shown to compare favorably with these methods.

ADHD among young adults born at extremely low birth weight: the role of fluid intelligence in childhood

PubMed Central

Lahat, Ayelet; Van Lieshout, Ryan J.; Saigal, Saroj; Boyle, Michael H.; Schmidt, Louis A.

2014-01-01

Poor executive function (EF) has been linked to attention-deficit/hyperactivity disorder (ADHD). Children born at extremely low birth weight (ELBW; <1000 g) have been found to show both poor EF, as well as elevated levels of symptoms of ADHD. In the present study, we examined whether fluid intelligence moderates the link between birth weight and later ADHD symptoms by prospectively following a cohort of 179 survivors who were born at ELBW. When participants were 8 years-old, they were matched with 145 normal birth weight (NBW; ≥2500 g) control participants. At age 8, fluid intelligence was measured, and during young adulthood (ages 22–26), participants' self-reported levels of ADHD symptoms were examined. We found that ELBW survivors, who also showed poor fluid intelligence, had the highest rates of ADHD symptoms, and particularly, symptoms of inattention. These findings point to the importance of examining developmental trajectories that contribute to risk for psychopathology in those exposed to intrauterine adversity. PMID:24904465

A New Stress-Based Model of Political Extremism: Personal Exposure to Terrorism, Psychological Distress, and Exclusionist Political Attitudes.

PubMed

Canetti-Nisim, Daphna; Halperin, Eran; Sharvit, Keren; Hobfoll, Stevan E

2009-06-01

Does exposure to terrorism lead to hostility toward minorities? Drawing on theories from clinical and social psychology, we propose a stress-based model of political extremism in which psychological distress-which is largely overlooked in political scholarship-and threat perceptions mediate the relationship between exposure to terrorism and attitudes toward minorities. To test the model, a representative sample of 469 Israeli Jewish respondents was interviewed on three occasions at six-month intervals. Structural Equation Modeling indicated that exposure to terrorism predicted psychological distress (t1), which predicted perceived threat from Palestinian citizens of Israel (t2), which, in turn, predicted exclusionist attitudes toward Palestinian citizens of Israel (t3). These findings provide solid evidence and a mechanism for the hypothesis that terrorism introduces nondemocratic attitudes threatening minority rights. It suggests that psychological distress plays an important role in political decision making and should be incorporated in models drawing upon political psychology.

The role of hydrological initial conditions on Atmospheric River floods in the Russian River basin

NASA Astrophysics Data System (ADS)

Cao, Q.; Mehran, A.; Ralph, M.; Cannon, F.; Lettenmaier, D. P.

2017-12-01

A body of work over the last decade or so has demonstrated that most major floods along the U.S. West Coast are attributable to Atmospheric Rivers (ARs). Antecedent hydrological conditions play an important part in the natural links between precipitation and floods, and this is especially the case in the Pacific Coastal region where precipitation is strongly winter-dominant, and many potentially flood-inducing events occur relatively early in the wet season. The Russian River Basin has these characteristics, the result of which is mostly dry soils at the onset of the fall precipitation season. There is therefore a tradeoff in terms of flood potential between the strength of AR events, and the time history of previous precipitation that has begun to wet soils and raise local water tables. In order to examine flood responses associated with varying precursor hydrological conditions, we first constructed a data set of AR events that were coincident with Peaks Over Threshold (POT) extreme discharge events at selected USGS stream gauges throughout the Russian River basin. We investigated the role of antecedent soil moisture and water table conditions on historical AR flooding, initially using an exploratory data analysis approach. We then implemented the Distributed Hydrology-Soil-Vegetation Model (DHSVM) over the entire basin and conducted modeling experiments for each of the POT events under climatological and extreme antecedent conditions. We reconstructed climatological soil moisture by assimilating in situ observations into long-term soil moisture simulations from the UCLA Western U.S. Drought Monitoring System. We explore an envelope of frequency distributions of floods given a range of AR-related extreme precipitation and various initial hydrologic conditions, which eventually should have implications for flood management decision-making.

Quantitative comparison of the expression of myogenic regulatory factors in flounder ( Paralichthys olivaceus) embryos and adult tissues

NASA Astrophysics Data System (ADS)

Zhang, Yuqing; Tan, Xungang; Xu, Peng; Sun, Wei; Xu, Yongli; Zhang, Peijun

2010-03-01

MyoD, Myf5, and myogenin are myogenic regulatory factors that play important roles during myogenesis. It is thought that MyoD and Myf5 are required for myogenic determination, while myogenin is important for terminal differentiation and lineage maintenance. To better understand the function of myogenic regulatory factors in muscle development of flounder, an important economic fish in Asia, real-time quantitative RT-PCR was used to characterize the expression patterns of MyoD, Myf5, and myogenin at early stages of embryo development, and in different tissues of the adult flounder. The results show that, Myf5 is the first gene to be expressed during the early stages of flounder development, followed by MyoD and myogenin. The expressions of Myf5, yoD, and myogenin at the early stages have a common characteristic: expression gradually increased to a peak level, and then gradually decreased to an extremely low level. In the adult flounder, the expression of the three genes in muscle is much higher than that in other tissues, indicating that they are important for muscle growth and maintenance of grown fish. During embryonic stages, the expression level of MyoD might serve an important role in the balance between muscle cell differentiation and proliferation. When the MyoD expression is over 30% of its highest level, the muscle cells enter the differentiation stage.

Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients.

PubMed

Taubert, H; Würl, P; Greither, T; Kappler, M; Bache, M; Bartel, F; Kehlen, A; Lautenschläger, C; Harris, L C; Kaushal, D; Füssel, S; Meye, A; Böhnke, A; Schmidt, H; Holzhausen, H-J; Hauptmann, S

2007-11-01

Cancer stem cells can play an important role in tumorigenesis and tumor progression. However, it is still difficult to detect and isolate cancer stem cells. An alternative approach is to analyse stem cell-associated gene expression. We investigated the coexpression of three stem cell-associated genes, Hiwi, hTERT and survivin, by quantitative real-time-PCR in 104 primary soft-tissue sarcomas (STS). Multivariate Cox's proportional hazards regression analyses allowed correlating gene expression with overall survival for STS patients. Coexpression of all three stem cell-associated genes resulted in a significantly increased risk of tumor-related death. Importantly, tumors of patients with the poorest prognosis were of all four tumor stages, suggesting that their risk is based upon coexpression of stem cell-associated genes rather than on tumor stage.

Physiology and toxicity of fluoride.

PubMed

Dhar, Vineet; Bhatnagar, Maheep

2009-01-01

Fluoride has been described as an essential element needed for normal development and growth of animals and extremely useful for human beings. Fluoride is abundant in the environment and the main source of fluoride to humans is drinking water. It has been proved to be beneficial in recommended doses, and at the same time its toxicity at higher levels has also been well established. Fluoride gets accumulated in hard tissues of the body and has been know to play an important role in mineralization of bone and teeth. At high levels it has been known to cause dental and skeletal fluorosis. There are suggested effects of very high levels of fluoride on various body organs and genetic material. The purpose of this paper is to review the various aspects of fluoride and its importance in human life.

Ethical principles in federal regulations: the case of children and research risks.

PubMed

Williams, P C

1996-04-01

Ethical principles play an important part not only in the promulgation of regulations but also in their application, i.e., enforcement and adjudication. while traditional ethical principles--promotion of welfare, freedom, and fairness--play an important role in both elements of regulation, some other kinds of ethical principles are significant as well. Principles governing the structure of decision processes should shape the structure and actions of agencies; principles of wise application should govern the work of those whose responsibility it is to apply regulatory language to particular situations. These points are demonstrated by investigating a case study: federal regulations designed to protect children involved in scientific research applied to a placebo study of the effects of recombinant human growth hormone on children of extremely short stature.

Rejection of Bromide and Bromate Ions by a Ceramic Membrane.

PubMed

Moslemi, Mohammadreza; Davies, Simon H; Masten, Susan J

2012-12-01

Effects of pH and the addition of calcium chloride (CaCl(2)) on bromate (BrO(3) (-)) and bromide (Br(-)) rejection by a ceramic membrane were investigated. Rejection of both ions increased with pH. At pH 8, the rejection of BrO(3) (-) and Br(-) was 68% and 63%, respectively. Donnan exclusion appears to play an important role in determining rejection of BrO(3) (-) and Br(-). In the presence of CaCl(2), rejection of BrO(3) (-) and Br(-) ions was greatly reduced, confirming the importance of electrostatic interactions in determining rejection of BrO(3) (-) and Br(-). The effect of Ca(2+) is so pronounced that in most natural waters, rejection of both BrO(3) (-) and Br(-) by the membrane would be extremely small.

Attributing extreme precipitation in the Black Sea region to sea surface warming

NASA Astrophysics Data System (ADS)

Meredith, Edmund; Semenov, Vladimir; Maraun, Douglas; Park, Wonsun; Chernokulsky, Alexander

2016-04-01

Higher sea surface temperatures (SSTs) warm and moisten the overlying atmosphere, increasing the low-level atmospheric instability, the moisture available to precipitating systems and, hence, the potential for intense convective systems. Both the Mediterranean and Black Sea regions have seen a steady increase in summertime SSTs since the early 1980s, by over 2 K in places. This raises the question of how this SST increase has affected convective precipitation extremes in the region, and through which mechanisms any effects are manifested. In particular, the Black Sea town of Krymsk suffered an unprecedented precipitation extreme in July 2012, which may have been influenced by Black Sea warming, causing over 170 deaths. To address this question, we adopt two distinct modelling approaches to event attribution and compare their relative merits. In the first, we use the traditional probabilistic event attribution approach involving global climate model ensembles representative of the present and a counterfactual past climate where regional SSTs have not increased. In the second, we use the conditional event attribution approach, taking the 2012 Krymsk precipitation extreme as a showcase example. Under the second approach, we carry out ensemble sensitivity experiments of the Krymsk event at convection-permitting resolution with the WRF regional model, and test the sensitivity of the event to a range of SST forcings. Both experiments show the crucial role of recent Black Sea warming in amplifying the 2012 Krymsk precipitation extreme. In the conditional event attribution approach, though, the explicit simulation of convective processes provides detailed insight into the physical mechanisms behind the extremeness of the event, revealing the dominant role of dynamical (i.e. static stability and vertical motions) over thermodynamical (i.e. increased atmospheric moisture) changes. Additionally, the wide range of SST states tested in the regional setup, which would be infeasible under the global modelling approach, reveal that the intensity of the Krymsk event responds highly nonlinearly to Black Sea warming and suggests a role for regional SST thresholds in more intense coastal convective extremes.

Ecosystem-scale VOC fluxes during an extreme drought in a ...

EPA Pesticide Factsheets

Considerable amounts and varieties of biogenic volatile organic compounds (BVOCs) are exchanged between vegetation and the surrounding air. These BVOCs play key ecological and atmospheric roles that must be adequately represented for accurately modeling the coupled biosphere-atmosphere-climate Earth system. One key uncertainty in existing models is the response of BVOC fluxes to an important global change process: drought. We describe the diurnal and seasonal variation in isoprene, monoterpene and methanol fluxes from a temperate forest ecosystem before, during, and after an extreme 2012 drought event in the Ozark region of the central USA. BVOC fluxes were dominated by isoprene, which attained high emission rates of up to 35.4 mg m-2 h-1 at midday. Methanol fluxes were characterized by net deposition in the morning, changing to a net emission flux through the rest of the daylight hours. Net flux of CO2 reached its seasonal maximum approximately a month earlier than isoprenoid fluxes, which highlights the differential response of photosynthesis and isoprenoid emissions to progressing drought conditions. Nevertheless, both processes were strongly suppressed under extreme drought, although isoprene fluxes remained relatively high compared to reported fluxes from other ecosystems. Methanol exchange was less affected by drought throughout the season, confirming the complex processes driving biogenic methanol fluxes. The fraction of daytime (7-17 h) assimilated carbo

Bactericidal effects of low-intensity extremely high frequency electromagnetic field: an overview with phenomenon, mechanisms, targets and consequences.

PubMed

Torgomyan, Heghine; Trchounian, Armen

2013-02-01

Low-intensity electromagnetic field (EMF) of extremely high frequencies is a widespread environmental factor. This field is used in telecommunication systems, therapeutic practices and food protection. Particularly, in medicine and food industries EMF is used for its bactericidal effects. The significant targets of cellular mechanisms for EMF effects at resonant frequencies in bacteria could be water (H(2)O), cell membrane and genome. The changes in H(2)O cluster structure and properties might be leading to increase of chemical activity or hydration of proteins and other cellular structures. These effects are likely to be specific and long-term. Moreover, cell membrane with its surface characteristics, substance transport and energy-conversing processes is also altered. Then, the genome is affected because the conformational changes in DNA and the transition of bacterial pro-phages from lysogenic to lytic state have been detected. The consequences for EMF interaction with bacteria are the changes in their sensitivity to different chemicals, including antibiotics. These effects are important to understand distinguishing role of bacteria in environment, leading to changed metabolic pathways in bacteria and their antibiotic resistance. This EMF may also affect the cell-to-cell interactions in bacterial populations, since bacteria might interact with each other through EMF of sub-extremely high frequency range.

The response of zooplankton communities to the 2016 extreme hydrological cycle in floodplain lakes connected to the Yangtze River in China.

PubMed

Zhang, Kun; Xu, Mei; Wu, Qili; Lin, Zhi; Jiang, Fangyuan; Chen, Huan; Zhou, Zhongze

2018-06-04

The Huayanghe Lakes play an important role in the Yangtze floodplain in China and had extremely high water levels during the summer of 2016. Monitoring data was collected in an effort to understand the impact of this change on the crustacean zooplankton composition and abundance and the biomass variation in the Huayanghe Lakes between a regular hydrological cycle (RHC) and an extreme hydrological cycle (EHC). The crustacean zooplankton community composition, abundance, and biomass in the floodplain lakes were markedly affected by the water-level disturbance. The number of species was lower in the RHC, but the mean density and biomass decreased from 93.84 ± 13.29 ind./L and 6.11 ± 0.89 mg/L, respectively, in the RHC to 66.62 ± 10.88 ind./L and 1.22 ± 0.26 mg/L, respectively, in the EHC. Pearson correlations and redundancy analyses revealed the environmental factors with the most significant impact on the crustacean zooplankton community differed between the RHC and EHC cycles. Little previous information exists on the zooplankton in these lakes, and the present study provides data on the zooplankton composition, abundance, and biomass, both at baseline and in response to hydrological changes.

Storms or cold fronts? What is really responsible for the extreme waves regime in the Colombian Caribbean coast

NASA Astrophysics Data System (ADS)

Otero, L. J.; Ortiz-Royero, J. C.; Ruiz-Merchan, J. K.; Higgins, A. E.; Henriquez, S. A.

2015-05-01

On Friday, 7 March 2009, a 200 m-long section of the tourist pier in Puerto Colombia collapsed under the impact of the waves generated by a cold front in the area. The aim of this study is to determine the contribution and importance of cold fronts and storms on extreme waves in different areas of the Colombian Caribbean to determine the degree of the threat posed by the flood processes to which these coastal populations are exposed and the actions to which coastal engineering constructions should be subject. In the calculation of maritime constructions, the most important parameter is the wave's height; therefore, it is necessary to definitively know the design wave height to which a coastal engineering structure should be resistant. This wave height varies according to the return period considered. Using Gumbel's extreme value methodology, the significant height values for the study area were calculated. The methodology was evaluated using data from the re-analysis of the spectral NOAA Wavewatch III (WW3) model for 15 points along the 1600 km of the Colombia Caribbean coast (continental and insular) of the last 15 years. The results demonstrated that the extreme waves caused by tropical cyclones and cold fronts have different effects along the Colombian Caribbean coast. Storms and hurricanes are of greater importance in the Guajira Peninsula (Alta Guajira). In the central area formed by Baja Guajira, Santa Marta, Barranquilla, and Cartagena, the strong influence of cold fronts on extreme waves is evident. On the other hand, in the southern region of the Colombian Caribbean coast, from the Gulf of Morrosquillo to the Gulf of Urabá, even though extreme waves are lower than in the previous regions, extreme waves are dominated mainly by the passage of cold fronts. Extreme waves in the San Andrés and Providencia insular region present a different dynamic from that in the continental area due to its geographic location. The wave heights in the extreme regime are similar in magnitude to those found in Alta Guajira, but the extreme waves associated with the passage of cold fronts in this region have lower return periods than the extreme waves associated with hurricane season. These results are of great importance when evaluating the threat of extreme waves in the coastal and port infrastructure, for purposes of the design of new constructions, and in the coastal flood processes due to run-up because, according to the site of interest in the coast, the forces that shape extreme waves are not the same.

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

PubMed Central

Hummitzsch, Katja; Anderson, Richard A.; Wilhelm, Dagmar; Wu, Ji; Telfer, Evelyn E.; Russell, Darryl L.; Robertson, Sarah A.

2015-01-01

Exploring stem cells in the mammalian ovary has unleashed a Pandora's box of new insights and questions. Recent evidence supports the existence of stem cells of a number of the different cell types within the ovary. The evidence for a stem cell model producing mural granulosa cells and cumulus cells is strong, despite a limited number of reports. The recent identification of a precursor granulosa cell, the gonadal ridge epithelial-like cell, is exciting and novel. The identification of female germline (oogonial) stem cells is still very new and is currently limited to just a few species. Their origins and physiological roles, if any, are unknown, and their potential to produce oocytes and contribute to follicle formation in vivo lacks robust evidence. The precursor of thecal cells remains elusive, and more compelling data are needed. Similarly, claims of very small embryonic-like cells are also preliminary. Surface epithelial cells originating from gonadal ridge epithelial-like cells and from the mesonephric epithelium at the hilum of the ovary have also been proposed. Another important issue is the role of the stroma in guiding the formation of the ovary, ovigerous cords, follicles, and surface epithelium. Immune cells may also play key roles in developmental patterning, given their critical roles in corpora lutea formation and regression. Thus, while the cellular biology of the ovary is extremely important for its major endocrine and fertility roles, there is much still to be discovered. This review draws together the current evidence and perspectives on this topic. PMID:25541635

NAD and the aging process: Role in life, death and everything in between.

PubMed

Chini, Claudia C S; Tarragó, Mariana G; Chini, Eduardo N

2017-11-05

Life as we know it cannot exist without the nucleotide nicotinamide adenine dinucleotide (NAD). From the simplest organism, such as bacteria, to the most complex multicellular organisms, NAD is a key cellular component. NAD is extremely abundant in most living cells and has traditionally been described to be a cofactor in electron transfer during oxidation-reduction reactions. In addition to participating in these reactions, NAD has also been shown to play a key role in cell signaling, regulating several pathways from intracellular calcium transients to the epigenetic status of chromatin. Thus, NAD is a molecule that provides an important link between signaling and metabolism, and serves as a key molecule in cellular metabolic sensoring pathways. Importantly, it has now been clearly demonstrated that cellular NAD levels decline during chronological aging. This decline appears to play a crucial role in the development of metabolic dysfunction and age-related diseases. In this review we will discuss the molecular mechanisms responsible for the decrease in NAD levels during aging. Since other reviews on this subject have been recently published, we will concentrate on presenting a critical appraisal of the current status of the literature and will highlight some controversial topics in the field. In particular, we will discuss the potential role of the NADase CD38 as a driver of age-related NAD decline. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The Unfolded Protein Response in Chronic Obstructive Pulmonary Disease

PubMed Central

2016-01-01

Accumulation of nonfunctional and potentially cytotoxic, misfolded proteins in chronic obstructive pulmonary disease (COPD) is believed to contribute to lung cell apoptosis, inflammation, and autophagy. Because of its fundamental role as a quality control system in protein metabolism, the “unfolded protein response” (UPR) is of potential importance in the pathogenesis of COPD. The UPR comprises a series of transcriptional, translational, and post-translational processes that decrease protein synthesis while enhancing protein folding capacity and protein degradation. Several studies have suggested that the UPR contributes to lung cell apoptosis and lung inflammation in at least some subjects with human COPD. However, information on the prevalence of the UPR in subjects with COPD, the lung cells that manifest a UPR, and the role of the UPR in the pathogenesis of COPD is extremely limited and requires additional study. PMID:27115948

The Unfolded Protein Response in Chronic Obstructive Pulmonary Disease.

PubMed

Kelsen, Steven G

2016-04-01

Accumulation of nonfunctional and potentially cytotoxic, misfolded proteins in chronic obstructive pulmonary disease (COPD) is believed to contribute to lung cell apoptosis, inflammation, and autophagy. Because of its fundamental role as a quality control system in protein metabolism, the "unfolded protein response" (UPR) is of potential importance in the pathogenesis of COPD. The UPR comprises a series of transcriptional, translational, and post-translational processes that decrease protein synthesis while enhancing protein folding capacity and protein degradation. Several studies have suggested that the UPR contributes to lung cell apoptosis and lung inflammation in at least some subjects with human COPD. However, information on the prevalence of the UPR in subjects with COPD, the lung cells that manifest a UPR, and the role of the UPR in the pathogenesis of COPD is extremely limited and requires additional study.

Population variation revealed high-altitude adaptation of Tibetan mastiffs.

PubMed

Li, Yan; Wu, Dong-Dong; Boyko, Adam R; Wang, Guo-Dong; Wu, Shi-Fang; Irwin, David M; Zhang, Ya-Ping

2014-05-01

With the assistance of their human companions, dogs have dispersed into new environments during the expansion of human civilization. Tibetan Mastiff (TM), a native of the Tibetan Plateau, was derived from the domesticated Chinese native dog and, like Tibetans, has adapted to the extreme environment of high altitude. Here, we genotyped genome-wide single-nucleotide polymorphisms (SNPs) from 32 TMs and compared them with SNPs from 20 Chinese native dogs and 14 gray wolves (Canis lupus). We identified 16 genes with signals of positive selection in the TM, with 12 of these candidate genes associated with functions that have roles in adaptation to high-altitude adaptation, such as EPAS1, SIRT7, PLXNA4, and MAFG that have roles in responses to hypoxia. This study provides important information on the genetic diversity of the TM and potential mechanisms for adaptation to hypoxia.

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets

PubMed Central

Nisar, Shaista; Daly, Martina E.; Federici, Augusto B.; Artoni, Andrea; Mumford, Andrew D.; Watson, Stephen P.

2011-01-01

The platelet P2Y12 purinoceptor (P2Y12R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y12R function is compromised after deletion or mutation of the 4 amino acids at the extreme C-terminus of this receptor (ETPM), a putative postsynaptic density 95/disc large/zonula occludens-1 (PDZ)–binding motif. In cell line models, removal of this sequence or mutation of one of its core residues (P341A), attenuates receptor internalization and receptor recycling back to the membrane, thereby blocking receptor resensitization. The physiologic significance of these findings in the regulation of platelet function is shown by identification of a patient with a heterozygous mutation in the PDZ binding sequence of their P2Y12R (P341A) that is associated with reduced expression of the P2Y12R on the cell surface. Importantly, platelets from this subject showed significantly compromised P2Y12R recycling, emphasizing the importance of the extreme C-terminus of this receptor to ensure correct receptor traffic. PMID:21937696

Mangrove species' responses to winter air temperature extremes in China

USGS Publications Warehouse

Chen, Luzhen; Wang, Wenqing; Li, Qingshun Q.; Zhang, Yihui; Yang, Shengchang; Osland, Michael J.; Huang, Jinliang; Peng, Congjiao

2017-01-01

The global distribution and diversity of mangrove forests is greatly influenced by the frequency and intensity of winter air temperature extremes. However, our understanding of how different mangrove species respond to winter temperature extremes has been lacking because extreme freezing and chilling events are, by definition, relatively uncommon and also difficult to replicate experimentally. In this study, we investigated species-specific variation in mangrove responses to winter temperature extremes in China. In 10 sites that span a latitudinal gradient, we quantified species-specific damage and recovery following a chilling event, for mangrove species within and outside of their natural range (i.e., native and non-native species, respectively). To characterize plant stress, we measured tree defoliation and chlorophyll fluorescence approximately one month following the chilling event. To quantify recovery, we measured chlorophyll fluorescence approximately nine months after the chilling event. Our results show high variation in the geographic- and species-specific responses of mangroves to winter temperature extremes. While many species were sensitive to the chilling temperatures (e.g., Bruguiera sexangula and species in the Sonneratia and Rhizophora genera), the temperatures during this event were not cold enough to affect certain species (e.g., Kandelia obovata, Aegiceras corniculatum, Avicennia marina, and Bruguiera gymnorrhiza). As expected, non-native species were less tolerant of winter temperature extremes than native species. Interestingly, tidal inundation modulated the effects of chilling. In comparison with other temperature-controlled mangrove range limits across the world, the mangrove range limit in China is unique due to the combination of the following three factors: (1) Mangrove species diversity is comparatively high; (2) winter air temperature extremes, rather than means, are particularly intense and play an important ecological role; and (3) due to afforestation and restoration efforts, several species of non-native mangroves have been introduced beyond their natural range limits. Hence, from a global perspective, mangroves in China provide valuable opportunities to advance understanding of the effects of freezing and chilling temperatures on mangroves. Within the context of climate change, our findings provide a foundation for better understanding and preparing for mangrove species-specific responses to future changes in the duration and intensity of winter temperature extremes.

Facile and rapid synthesis of Pd nanodendrites for electrocatalysis and surface-enhanced Raman scattering applications

NASA Astrophysics Data System (ADS)

Kannan, Palanisamy; Dolinska, Joanna; Maiyalagan, Thandavarayan; Opallo, Marcin

2014-09-01

Numerous properties from metal nanostructures can be tuned by controlling both their size and shape. In particular, the latter is extremely important because the type of crystalline surface affects the surface electronic density. This paper describes a simple approach to the synthesis of highly-structured, anisotropic palladium nanostructured dendrites. They were obtained using an eco-friendly biomolecule 5-hydroxytryptophan, which acts as both a reducing and stabilizing agent. The growth mechanism is proposed for the evolution of dendrites morphology. It was found that the concentration of 5-hydroxytryptophan played a vital role on the morphology of the nanostructured Pd dendrites. This nanomaterial shows enhanced electrocatalytic performance towards the oxidation of formic acid, and it exhibits surface-enhanced Raman scattering properties towards the prostate specific antigen. These properties may be explored in fuel cells and biosensors, respectively.Numerous properties from metal nanostructures can be tuned by controlling both their size and shape. In particular, the latter is extremely important because the type of crystalline surface affects the surface electronic density. This paper describes a simple approach to the synthesis of highly-structured, anisotropic palladium nanostructured dendrites. They were obtained using an eco-friendly biomolecule 5-hydroxytryptophan, which acts as both a reducing and stabilizing agent. The growth mechanism is proposed for the evolution of dendrites morphology. It was found that the concentration of 5-hydroxytryptophan played a vital role on the morphology of the nanostructured Pd dendrites. This nanomaterial shows enhanced electrocatalytic performance towards the oxidation of formic acid, and it exhibits surface-enhanced Raman scattering properties towards the prostate specific antigen. These properties may be explored in fuel cells and biosensors, respectively. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr02896a

The Role of Authigenic Volcanic Ash in Marine Sediment

NASA Astrophysics Data System (ADS)

Scudder, R.; McKinley, C. C.; Thomas, D. J.; Murray, R. W.

2016-12-01

Marine sediments are a fundamental archive of the history of weathering and erosion, biological productivity, volcanic activity, patterns of deep-water formation and circulation, and a multitude of other earth, ocean, and atmosphere processes. In particular, the record and consequences of volcanic eruptions have long fascinated humanity. Volcanic ash layers are often visually stunning, and can have thicknesses of 10s of cm or more. While the ash layer records are of great importance by themselves, we are missing a key piece of information-that of the very fined grained size fractions. Dispersed ash is the very fine grained-component that has either been mixed into the bulk sediment by bioturbation, or is deposited from subaqueous eruptions, erosion of terrestrial deposits, general input during time periods of elevated global volcanism, or other mechanisms, plays an important role in the marine sediment. The presence of dispersed ash in the marine record has previously been relatively over-looked as it is difficult to identify petrographically due to its commonly extremely fine grain size and/or alteration to authigenic clay. The dispersed ash, either altered or unaltered, is extremely difficult to differentiate from detrital/terrigenous/authigenic clay, as they are all "aluminosilicates". Here we apply a combined geochemical, isotopic, and statistical technique that enables us to resolve volcanic from detrital terrigenous inputs at DSDP/ODP/IODP sites from both the Brazil Margin and the Northwest Pacific Oceans. Incorporating the combined geochemical/statistical techniques with radiogenic isotope records allows us to address paleoceanographic questions in addition to studies of the effect of sediment fluxes on carbon cycling, the relationship between volcanic ash and biological productivity of the open ocean and nutrient availability for subseafloor microbial life.

Narcissism as a Moderator of Satisfaction with Body Image in Young Women with Extreme Underweight and Obesity

PubMed Central

Lipowska, Małgorzata; Lipowski, Mariusz

2015-01-01

Objective Body weight and age constitute main determinants of body image in women. We analyzed the role of narcissism as a moderator of body image in young women representing various extremes of body weight. Methods The study included 325 women between 18 and 35 years, qualified into three BMI categories: obese women (BMI > 30.0, n = 72), severely underweight women who did not satisfy the remaining criteria of anorexia (BMI < 17.5, n = 85), and women with normal body weight (21.7 < “ideal BMI” > 22.7, n = 168). Satisfaction with body image was determined with Multidimensional Body-Self Relations Questionnaire and Body Esteem Scale, while narcissism was measured with Narcissistic Personality Inventory. Principal Findings We revealed that narcissism has significant impact on the body image of women who are extremely underweight or obese. Vanity and Leadership were narcissism dimensions which played significant role in slim women, as compared to Vanity and Self-Sufficiency in obese women. Conclusion The role of narcissism as a modulator of self-satisfaction with one’s body varies depending on BMI level: extremely underweight women and obese individuals constitute groups in which narcissism has the strongest impact on the self-satisfaction with body. PMID:25961302

Protecting muscle ATP: positive roles for peripheral defense mechanisms-introduction.

PubMed

Myburgh, Kathryn H

2004-01-01

Skeletal muscle has evolved an impressive array of mechanisms for peripherally mediated control of ATP homeostasis. Some of these mechanisms are intracellular, and others are extracellular and include influences on the cross-bridge cycle itself and substrate supply. This paper introduces three distinctly different topics that nevertheless all have ATP defense in common. The role of ADP in fatigue is controversial but has recently been more clearly delineated so that an effect on alleviating force declines during extreme fatigue is plausible. AMP plays its role by activating the protein-kinase, AMPK, which is a key sensor of cellular energy stress. AMPK has different isoforms, is not uniformly distributed in the cell, and its activation is carefully controlled. It has multiple effects including improvements in substrate supply for the metabolic pathways producing ATP and inhibition of anabolic processes to further spare ATP. Red blood cells have the capacity to sense hypoxia and to release vasodilators where there is a locally increased demand for blood supply. The papers in this series emphasize the important positive roles of metabolites and sensors of fatigue in the balance between ATP supply and demand.

Personality disorders and culture: contemporary clinical views (Part B).

PubMed

Alarcón, R D; Foulks, E F

1995-01-01

This article reviews the basic concepts surrounding the clinical relationships between culture and personality disorders (PDs). Part A of this article, which appeared in Cultural Diversity and Mental Health, Vol. 1, No. 1, pp 3-17 (1995), examined the interpretive/explanatory and pathogenic/ pathoplastic roles of culture. Herein, culture's role as a diagnostic/nosological factor is discussed through the use of measurement instruments and the cultural formulation included in DSM-IV (American Psychiatric Association, 1994). In addition to these three roles, some authors would also consider a therapeutic/protective function for cultured in PDs. Following a critique of the biological perspective, a research model based on the definition of the cultural profile and the estimation of the cultural distance between clinical examiners and populations is proposed. It is important to reject both biological reductionism and the extremes of cultural determinism, in order to better assess the intraethnic distribution of psychopathology, and interethnic variations represented by the notion of cultural relativism.

The roles of ebolavirus glycoproteins in viral pathogenesis.

PubMed

Ning, Yun-Jia; Deng, Fei; Hu, Zhihong; Wang, Hualin

2017-02-01

Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against EVD. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics. Ebolavirus encodes several forms of glycoproteins (GPs), which have some interesting characteristics, including the transcriptional editing coding strategy and extensive O-glycosylation modification, clustered in the mucin-like domain of GP1, full-length GP (GP 1,2 ), and shed GP. In addition to the canonical role of the spike protein, GP 1,2 , in viral entry, ebolavirus GPs appear to have multiple additional functions, likely contributing to the complex pathogenesis of the virus. Here, we review the roles of ebolavirus GPs in viral pathogenesis.

Cell Cycle Control in the Early Embryonic Development of Aquatic Animal Species

PubMed Central

Siefert, Joseph C.; Clowdus, Emily A.; Sansam, Christopher L.

2016-01-01

The cell cycle is integrated with many aspects of embryonic development. Not only is proper control over the pace of cell proliferation important, but also the timing of cell cycle progression is coordinated with transcription, cell migration, and cell differentiation. Due to the ease with which the embryos of aquatic organisms can be observed and manipulated, they have been a popular choice for embryologists throughout history. In the cell cycle field, aquatic organisms have been extremely important because they have played a major role in the discovery and analysis of key regulators of the cell cycle. In particular, the frog Xenopus laevis has been instrumental for understanding how the basic embryonic cell cycle is regulated. More recently, the zebrafish has been used to understand how the cell cycle is remodeled during vertebrate development and how it is regulated during morphogenesis. This review describes how some of the unique strengths of aquatic species have been leveraged for cell cycle research and suggests how species such as Xenopus and zebrafish will continue to reveal the roles of the cell cycle in human biology and disease. PMID:26475527

The role of fission in Supernovae r-process nucleosynthesis

NASA Astrophysics Data System (ADS)

Otsuki, Kaori; Kajino, Toshitaka; Sumiyoshi, Kosuke; Ohta, Masahisa; Mathews, J. Grant

2001-10-01

The r-process elements are presumed to be produced in an explosive environment with short timescale at high entropy, like type-II supernova explosion. Intensive flux of free neutrons are absorbed successively by seed elements to form the nuclear reaction flow on extremely unstable nuclei on the neutron rich side. It would probe our knowledge of the properties of nulei far from the beta stability. It is also important in astronomy since this process forms the long-lived nuclear chronometers Thorium and Uranium that are utilised dating the age of the Milky Way. In our previous work, we showed that the succesful r-process nucleosynthesis can occure above young, hot protoneutron star. Although these long-lived heavy elements are produced comparable amounts to observation in several supernova models which we constructed, fission and alpha-decay were not included there. The fission products could play an important role in setting actinide yields which are used as cosmochronometers. In this talk, we report an infulence of fission on actinide yields and on estimate of Galactic age as well. We also discuss fission yields at lighter elements (Z ~ 50).

The Halophile protein database.

PubMed

Sharma, Naveen; Farooqi, Mohammad Samir; Chaturvedi, Krishna Kumar; Lal, Shashi Bhushan; Grover, Monendra; Rai, Anil; Pandey, Pankaj

2014-01-01

Halophilic archaea/bacteria adapt to different salt concentration, namely extreme, moderate and low. These type of adaptations may occur as a result of modification of protein structure and other changes in different cell organelles. Thus proteins may play an important role in the adaptation of halophilic archaea/bacteria to saline conditions. The Halophile protein database (HProtDB) is a systematic attempt to document the biochemical and biophysical properties of proteins from halophilic archaea/bacteria which may be involved in adaptation of these organisms to saline conditions. In this database, various physicochemical properties such as molecular weight, theoretical pI, amino acid composition, atomic composition, estimated half-life, instability index, aliphatic index and grand average of hydropathicity (Gravy) have been listed. These physicochemical properties play an important role in identifying the protein structure, bonding pattern and function of the specific proteins. This database is comprehensive, manually curated, non-redundant catalogue of proteins. The database currently contains 59 897 proteins properties extracted from 21 different strains of halophilic archaea/bacteria. The database can be accessed through link. Database URL: http://webapp.cabgrid.res.in/protein/ © The Author(s) 2014. Published by Oxford University Press.

Interactions between drugs and polymers influencing hot melt extrusion.

PubMed

Li, Yongcheng; Pang, Huishi; Guo, Zhefei; Lin, Ling; Dong, Yixuan; Li, Ge; Lu, Ming; Wu, Chuangbin

2014-02-01

Hot melt extrusion (HME) as a technique for producing amorphous solid dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge for the application of HME is the thermal degradation of drug, poor physical stability of ASD and precipitation of drug during dissolution. Interactions between drugs and polymers may play an important role in overcoming these barriers. In this review, influence of drug-polymer interactions on HME and the methods for characterizing the drug-polymer interactions were reviewed. Strong drug-polymer interactions, especially ionic interactions and hydrogen bonds, are helpful to improving the thermal stability of drug during HME, enhancing the physical stability of ASD during storage and maintaining supersaturated solution after dissolution in gastrointestinal tract. The interactions can be quantitatively and qualitatively characterized by many analysing methods. As many factors collectively determine the properties of HME products, drug-polymer interactions play an extremely important role. However, the action mechanisms of drug-polymer interactions need intensive investigation to provide more useful information for optimizing the formulation and the process parameters of HME. © 2013 Royal Pharmaceutical Society.

Hip abductor function and lower extremity landing kinematics: sex differences.

PubMed

Jacobs, Cale A; Uhl, Timothy L; Mattacola, Carl G; Shapiro, Robert; Rayens, William S

2007-01-01

Rapid deceleration during sporting activities, such as landing from a jump, has been identified as a common mechanism of acute knee injury. Research into the role of potential sex differences in hip abductor function with lower extremity kinematics when landing from a jump is limited. To evaluate sex differences in hip abductor function in relation to lower extremity landing kinematics. 2 x 2 mixed-model factorial design using a between-subjects factor (sex) and a repeated factor (test). University laboratory. A sample of convenience consisting of 30 healthy adults (15 women, 15 men) with no history of lower extremity surgery and no lower extremity injuries within 6 months of testing. Landing kinematics were assessed as subjects performed 3 pre-exercise landing trials that required them to hop from 2 legs and land on a single leg. Isometric peak torque (PT) of the hip abductors was measured, followed by an endurance test during which subjects maintained 50% of their PT to the limits of endurance. After a 15-minute rest period, subjects completed a 30-second bout of isometric hip abduction, from which we calculated the percentage of endurance capacity (%E). Immediately after exercise, subjects completed 3 postexercise landing trials. PT, %E, and peak joint displacement (PJD) of the hip and knee in all 3 planes of motion. Women demonstrated lower PT values (5.8 +/- 1.2% normalized to body weight and height) than did their male counterparts (7.2 +/- 1.5% normalized to body weight and height, P = .009). However, no sex differences were seen in %E. Women also demonstrated larger knee valgus PJD (7.26 degrees +/- 6.61 degrees) than did men (3.29 degrees +/- 3.54 degrees, P = .04). Women's PT was moderately correlated with hip flexion, adduction, and knee valgus PJD; however, PT did not significantly correlate with men's landing kinematics. Regardless of sex, hip flexion (P = .002) and hip adduction (P = .001) were significantly increased following the 30-second bout of exercise. Women demonstrated lower hip abductor PT and increased knee valgus PJD when landing from a jump, potentially increasing the risk of acute knee injury. Furthermore, correlations between hip abductor strength and landing kinematics were generally larger for women than for men, suggesting that hip abductor strength may play a more important role in neuromuscular control of the knee for women.

Extreme Programming in a Research Environment

NASA Technical Reports Server (NTRS)

Wood, William A.; Kleb, William L.

2002-01-01

This article explores the applicability of Extreme Programming in a scientific research context. The cultural environment at a government research center differs from the customer-centric business view. The chief theoretical difficulty lies in defining the customer to developer relationship. Specifically, can Extreme Programming be utilized when the developer and customer are the same person? Eight of Extreme Programming's 12 practices are perceived to be incompatible with the existing research culture. Further, six of the nine 'environments that I know don't do well with XP' apply. A pilot project explores the use of Extreme Programming in scientific research. The applicability issues are addressed and it is concluded that Extreme Programming can function successfully in situations for which it appears to be ill-suited. A strong discipline for mentally separating the customer and developer roles is found to be key for applying Extreme Programming in a field that lacks a clear distinction between the customer and the developer.

Insertion sequences enrichment in extreme Red sea brine pool vent.

PubMed

Elbehery, Ali H A; Aziz, Ramy K; Siam, Rania

2017-03-01

Mobile genetic elements are major agents of genome diversification and evolution. Limited studies addressed their characteristics, including abundance, and role in extreme habitats. One of the rare natural habitats exposed to multiple-extreme conditions, including high temperature, salinity and concentration of heavy metals, are the Red Sea brine pools. We assessed the abundance and distribution of different mobile genetic elements in four Red Sea brine pools including the world's largest known multiple-extreme deep-sea environment, the Red Sea Atlantis II Deep. We report a gradient in the abundance of mobile genetic elements, dramatically increasing in the harshest environment of the pool. Additionally, we identified a strong association between the abundance of insertion sequences and extreme conditions, being highest in the harshest and deepest layer of the Red Sea Atlantis II Deep. Our comparative analyses of mobile genetic elements in secluded, extreme and relatively non-extreme environments, suggest that insertion sequences predominantly contribute to polyextremophiles genome plasticity.

The role of atmospheric diagnosis and Big Data science in improving hydroclimatic extreme prediction and the merits of climate informed prediction for future water resources management

NASA Astrophysics Data System (ADS)

Lu, Mengqian; Lall, Upmanu

2017-04-01

The threats that hydroclimatic extremes pose to sustainable development, safety and operation of infrastructure are both severe and growing. Recent heavy precipitation triggered flood events in many regions and increasing frequency and intensity of extreme precipitation suggested by various climate projections highlight the importance of understanding the associated hydrometeorological patterns and space-time variability of such extreme events, and developing a new approach to improve predictability with a better estimation of uncertainty. This clear objective requires the optimal utility of Big Data analytics on multi-source datasets to extract informative predictors from the complex ocean-atmosphere coupled system and develop a statistical and physical based framework. The proposed presentation includes the essence of our selected works in the past two years, as part of our Global Floods Initiatives. Our approach for an improved extreme prediction begins with a better understanding of the associated atmospheric circulation patterns, under the influence and regulation of slowly changing oceanic boundary conditions [Lu et al., 2013, 2016a; Lu and Lall, 2016]. The study of the associated atmospheric circulation pattern and the regulation of teleconnected climate signals adopted data science techniques and statistical modeling recognizing the nonstationarity and nonlinearity of the system, as the underlying statistical assumptions of the classical extreme value frequency analysis are challenged in hydroclimatic studies. There are two main factors that are considered important for understanding how future flood risk will change. One is the consideration of moisture holding capacity as a function of temperature, as suggested by Clausius-Clapeyron equation. The other is the strength of the convergence or convection associated with extreme precipitation. As convergence or convection gets stronger, rain rates can be expected to increase if the moisture is available. For extreme rainfall events in the mid-latitudes, tropical moisture sources related to strong convection from equatorial oceans were identified together with atmospheric circulation conditions that in favor of consistent transport and convergence of moisture [Lu et al., 2013; Lu and Lall, 2016]. Further, [Lu et al., 2016a] linked the influence of the slowly changing oceanic boundary conditions with the development of the global atmospheric circulation and showed that (1) strong convection over the oceans and the atmospheric moisture transport and flow convergence indicated by atmospheric pressure fields can determine where and when extreme precipitation occurs; and (2) the time-lagged spatial relationship between teleconnected oceanic signals and synoptic atmospheric circulations can improve the predictability of extreme precipitation globally over the next 30 days; such a forecast would be potentially very useful for flood preparation at a lead time that is well beyond the lead time of meteorological forecasts, and it corresponds to a gap in the predictability between quantitative precipitation forecasts and seasonal-to-interannual climate prediction. Lastly, we will demonstrate our most recent results showing the merits of utilizing climate informed forecasts for water resources management, considering irrigation supply, hydropower and flood control, with marked-based financial instruments [Lu et al., 2016b].

Multi-scale gyrokinetic simulations of an Alcator C-Mod, ELM-y H-mode plasma

NASA Astrophysics Data System (ADS)

Howard, N. T.; Holland, C.; White, A. E.; Greenwald, M.; Rodriguez-Fernandez, P.; Candy, J.; Creely, A. J.

2018-01-01

High fidelity, multi-scale gyrokinetic simulations capable of capturing both ion ({k}θ {ρ }s∼ { O }(1.0)) and electron-scale ({k}θ {ρ }e∼ { O }(1.0)) turbulence were performed in the core of an Alcator C-Mod ELM-y H-mode discharge which exhibits reactor-relevant characteristics. These simulations, performed with all experimental inputs and realistic ion to electron mass ratio ({({m}i/{m}e)}1/2=60.0) provide insight into the physics fidelity that may be needed for accurate simulation of the core of fusion reactor discharges. Three multi-scale simulations and series of separate ion and electron-scale simulations performed using the GYRO code (Candy and Waltz 2003 J. Comput. Phys. 186 545) are presented. As with earlier multi-scale results in L-mode conditions (Howard et al 2016 Nucl. Fusion 56 014004), both ion and multi-scale simulations results are compared with experimentally inferred ion and electron heat fluxes, as well as the measured values of electron incremental thermal diffusivities—indicative of the experimental electron temperature profile stiffness. Consistent with the L-mode results, cross-scale coupling is found to play an important role in the simulation of these H-mode conditions. Extremely stiff ion-scale transport is observed in these high-performance conditions which is shown to likely play and important role in the reproduction of measurements of perturbative transport. These results provide important insight into the role of multi-scale plasma turbulence in the core of reactor-relevant plasmas and establish important constraints on the the fidelity of models needed for predictive simulations.

Magnetic Resonance Imaging Evaluation of Cardiac Masses

PubMed Central

Braggion-Santos, Maria Fernanda; Koenigkam-Santos, Marcel; Teixeira, Sara Reis; Volpe, Gustavo Jardim; Trad, Henrique Simão; Schmidt, André

2013-01-01

Background Cardiac tumors are extremely rare; however, when there is clinical suspicion, proper diagnostic evaluation is necessary to plan the most appropriate treatment. In this context, cardiovascular magnetic resonance imaging (CMRI) plays an important role, allowing a comprehensive characterization of such lesions. Objective To review cases referred to a CMRI Department for investigation of cardiac and paracardiac masses. To describe the positive case series with a brief review of the literature for each type of lesion and the role of cardiovascular magnetic resonance imaging in evaluation. Methods Between August 2008 and December 2011, all cases referred for CMRI with suspicion of tumor involving the heart were reviewed. Cases with positive histopathological diagnosis, clinical evolution or therapeutic response compatible with the clinical suspicion and imaging findings were selected. Results Among the 13 cases included in our study, eight (62%) had histopathological confirmation. We describe five benign tumors (myxomas, rhabdomyoma and fibromas), five malignancies (sarcoma, lymphoma, Richter syndrome involving the heart and metastatic disease) and three non-neoplastic lesions (pericardial cyst, intracardiac thrombus and infectious vegetation). Conclusion CMRI plays an important role in the evaluation of cardiac masses of non-neoplastic and neoplastic origin, contributing to a more accurate diagnosis in a noninvasive manner and assisting in treatment planning, allowing safe clinical follow-up with good reproducibility. PMID:23887734

NARROW-LINE-WIDTH UV BURSTS IN THE TRANSITION REGION ABOVE SUNSPOTS OBSERVED BY IRIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hou, Zhenyong; Huang, Zhenghua; Xia, Lidong

Various small-scale structures abound in the solar atmosphere above active regions, playing an important role in the dynamics and evolution therein. We report on a new class of small-scale transition region structures in active regions, characterized by strong emissions but extremely narrow Si iv line profiles as found in observations taken with the Interface Region Imaging Spectrograph (IRIS). Tentatively named as narrow-line-width UV bursts (NUBs), these structures are located above sunspots and comprise one or multiple compact bright cores at sub-arcsecond scales. We found six NUBs in two data sets (a raster and a sit-and-stare data set). Among these, fourmore » events are short-lived with a duration of ∼10 minutes, while two last for more than 36 minutes. All NUBs have Doppler shifts of 15–18 km s{sup −1}, while the NUB found in sit-and-stare data possesses an additional component at ∼50 km s{sup −1} found only in the C ii and Mg ii lines. Given that these events are found to play a role in the local dynamics, it is important to further investigate the physical mechanisms that generate these phenomena and their role in the mass transport in sunspots.« less

Biological Hydropersulfides and Related Polysulfides: A New Concept and Perspective in Redox Biology.

PubMed

Fukuto, Jon M; Ignarro, Louis J; Nagy, Peter; Wink, David A; Kevil, Christopher G; Feelisch, Martin; Cortese-Krott, Miriam M; Bianco, Christopher L; Kumagai, Yoshito; Hobbs, Adrian J; Lin, Joseph; Ida, Tomoaki; Akaike, Takaaki

2018-05-12

The chemical biology of thiols (RSH, e.g., cysteine and cysteine containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS n H, RSS n R, n > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSS n H. RSSH of cysteine (Cys-SSH) has been found to be prevalent in mammalian systems along with Cys-SSH-containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys-SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Association between SCO2 mutation and extreme myopia in Japanese patients.

PubMed

Wakazono, Tomotaka; Miyake, Masahiro; Yamashiro, Kenji; Yoshikawa, Munemitsu; Yoshimura, Nagahisa

2016-07-01

To investigate the role of SCO2 in extreme myopia of Japanese patients. In total, 101 Japanese patients with extreme myopia (axial length of ≥30 mm) OU at the Kyoto University Hospital were included in this study. Exon 2 of SCO2 was sequenced by conventional Sanger sequencing. The detected variants were assessed using in silico prediction programs: SIFT, PolyPhen-2 and MutationTaster. To determine the frequency of the mutations in normal subjects, we referred to the 1000 Genomes Project data and the Human Genetic Variation Database (HGVD) in the Human Genetic Variation Browser. The average age of the participants was 62.9 ± 12.7 years. There were 31 males (30.7 %) and 70 females. Axial lengths were 31.76 ± 1.17 mm OD and 31.40 ± 1.07 mm OS, and 176 eyes (87.6 %) out of 201 eyes had myopic maculopathy of grade 2 or more. Among the 101 extremely myopic patients, one mutation (c.290 C > T;p.Ala97Val) in SCO2 was detected. This mutation was not found in the 1000 Genomes Project data or HGVD data. Variant type of the mutation was nonsynonymous. Although the SIFT prediction score was 0.350, the PolyPhen-2 probability was 0.846, thus predicting its pathogenicity to be possibly damaging. MutationTaster PhyloP was 1.268, suggesting that the mutation is conserved. We identified one novel possibility of an extreme myopia-causing mutation in SCO2. No other disease-causing mutation was found in 101 extremely myopic Japanese patients, suggesting that SCO2 plays a limited role in Japanese extreme myopia. Further investigation is required for better understanding of extreme myopia.

IPCC Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation

NASA Astrophysics Data System (ADS)

Field, C. B.; Stocker, T. F.; Barros, V. R.; Qin, D.; Ebi, K. L.; Midgley, P. M.

2011-12-01

The Summary for Policy Makers of the IPCC Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation will be approved by the world governments in November 2011. The focus of the Special Report is on climate change and its role in altering the frequency, severity, and impact of extreme events or disasters, and on the costs of both impacts and the actions taken to prepare for, respond to, and recover from extreme events and disasters. The emphasis is on understanding the factors that make people and infrastructure vulnerable to extreme events, on recent and future changes in the relationship between climate change and extremes, and on managing the risks of disasters over a wide range of spatial and temporal scales. The assessment considers a broad suite of adaptations and explores the limits to adaptation. The assessment was designed to build durable links and foundations for partnerships between the stakeholder communities focused on climate change and those focused on disaster risk reduction. The Special Report begins with material that frames the issues, followed by an assessment of the reasons that communities are vulnerable. Two chapters assess the role of past and future climate change in altering extremes and the impact of these on the physical environment and human systems. Three chapters assess available knowledge on impacts and adaptation, with separate chapters considering the literature, stakeholder relationships, and potential policy tools relevant to the local, national, and international scales. Longer-term components of adaptation to weather and climate extremes and disasters are assessed in the context of moving toward sustainability. The final chapter provides case studies that integrate themes across several chapters or are so unique that they need to be considered separately.

Educational Adventure Games.

ERIC Educational Resources Information Center

Williams, Fred D.

An adventure game is a role-playing game that usually, but not always, has some fantasy aspect. The role-playing aspect is the key element because players become personally involved when they assume a role, and defeat becomes personal and less acceptable than in other types of games. Computer-based role-playing games are extremely popular because…

Psychosocial burden among offshore drilling platform employees.

PubMed

Leszczyńska, Irena; Jeżewska, Maria

2010-01-01

Conditions of work on offshore drilling platforms are particularly hard due to extreme environmental situations created both by nature and technological processes. Oil drilling workers employed on the open sea are potentially exposed to permanently high stress. Apart from the obvious objective factors affecting drilling platform employees, a great role in the general work-related stress level is played by the working conditions and work-related psychosocial factors, defined according to Karask's concept as demands, control, and social support. A total of 184 drill platform workers were examined using objective and subjective research methods. The level of subjective stress among drilling platform workers is lower than the level of objective stress and the stress resulting from prognoses related with specificity of work in extremely hard conditions (audit). The examinations of drilling platform workers reveal a positive role of stress in psychological adaptation, being a special case of the "work ethos" and attachment to the firm. In such investigations of work-related stress on drilling platforms, which are very specific workplaces, a multi-aspect character, sociological and economic aspects, organizational culture conditions in the firm, and a tendency to conceal ailments and the stress experienced should be taken into account. It is important to apply measures referring to at least three different types of evidence (objective demands, subjective stress, health problems reported). Otherwise, the result reflecting work-related stress may not be objective and far from the truth.

Microsurgery within reconstructive surgery of extremities.

PubMed

Pheradze, I; Pheradze, T; Tsilosani, G; Goginashvili, Z; Mosiava, T

2006-05-01

Reconstructive surgery of extremities is an object of a special attention of surgeons. Vessel and nerve damages, deficiency of soft tissue, bone, associated with infection results in a complete loss of extremity function, it also raises a question of amputation. The goal of the study was to improve the role of microsurgery in reconstructive surgery of limbs. We operated on 294 patients with various diseases and damages of extremities: pathology of nerves, vessels, tissue loss. An original method of treatment of large simultaneous functional defects of limbs has been used. Good functional and aesthetic results were obtained. Results of reconstructive operations on extremities might be improved by using of microsurgery methods. Microsurgery is deemed as a method of choice for extremities' reconstructive surgery as far as outcomes achieved through application of microsurgical technique significantly surpass the outcomes obtained through the use of routine surgical methods.

Imaging of upper extremity stress fractures in the athlete.

PubMed

Anderson, Mark W

2006-07-01

Although it is much less common than injuries in the lower extremities, an upper extremity stress injury can have a significant impact on an athlete. If an accurate and timely diagnosis is to be made, the clinician must have a high index of suspicion of a stress fracture in any athlete who is involved in a throwing, weightlifting, or upper extremity weight-bearing sport and presents with chronic pain in the upper extremity. Imaging should play an integral role in the work-up of these patients; if initial radiographs are unrevealing, further cross-sectional imaging should be strongly considered. Although a three-phase bone scan is highly sensitive in this regard, MRI has become the study of choice at most centers.

The Role of Ambient Ozone in Epidemiologic Studies of Heat-Related Mortality

PubMed Central

Snowden, Jonathan M.; Kontgis, Caitlin; Tager, Ira B.

2012-01-01

Background: A large and growing literature investigating the role of extreme heat on mortality has conceptualized the role of ambient ozone in various ways, sometimes treating it as a confounder, sometimes as an effect modifier, and sometimes as a co-exposure. Thus, there is a lack of consensus about the roles that temperature and ozone together play in causing mortality. Objectives: We applied directed acyclic graphs (DAGs) to the topic of heat-related mortality to graphically represent the subject matter behind the research questions and to provide insight on the analytical options available. Discussion: On the basis of the subject matter encoded in the graphs, we assert that the role of ozone in studies of temperature and mortality is a causal intermediate that is affected by temperature and that can also affect mortality, rather than a confounder. Conclusions: We discuss possible questions of interest implied by this causal structure and propose areas of future work to further clarify the role of air pollutants in epidemiologic studies of extreme temperature. PMID:22899622

Cutaneous manifestations associated with adult-onset Still's disease: important diagnostic values.

PubMed

Yamamoto, Toshiyuki

2012-08-01

Adult-onset Still's disease (AOSD) is a systemic inflammatory condition, characterized by a high spiking fever, leukocytosis with neutrophilia, arthralgia, and skin rash. Typical skin rash is an evanescent, salmon-pink erythema predominantly involving extremities, which is included as one of the diagnostic criteria; however, recent findings show that not only typical evanescent rash but also various skin lesions are associated with AOSD. The representative characteristic skin lesion among the non-classical skin rash is called persistent pruritic papules and plaques, which presents erythematous, slightly scaly papules with linear configuration on the trunk. Interestingly, persistent pruritic papules and plaques show unique histological features such as peculiar, distinctive distribution of dyskeratotic keratinocytes in the cornified layers as well as in the epidermis. Other non-classical skin lesions include urticaria. Current insights suggest that several inflammatory cytokines such as interleukin-1 (IL-1), IL-6, IL-18, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) play a pathogenic role in AOSD. In particular, IL-18 is suggested to play a crucial role in activating macrophages, favoring Th1 type cytokine production. IL-18 induces IFN-γ, IL-17, and TNF-α, which may play an important pathogenic role in AOSD. It is important to recognize the common and/or uncommon skin conditions of AOSD for early correct diagnosis. In this review, various skin lesions are introduced, and the complication with histiocytic necrotizing lymphadenitis (Kikuchi disease) is further discussed.

Detection and attribution of extreme weather disasters

NASA Astrophysics Data System (ADS)

Huggel, Christian; Stone, Dáithí; Hansen, Gerrit

2014-05-01

Single disasters related to extreme weather events have caused loss and damage on the order of up to tens of billions US dollars over the past years. Recent disasters fueled the debate about whether and to what extent these events are related to climate change. In international climate negotiations disaster loss and damage is now high on the agenda, and related policy mechanisms have been discussed or are being implemented. In view of funding allocation and effective risk reduction strategies detection and attribution to climate change of extreme weather events and disasters is a key issue. Different avenues have so far been taken to address detection and attribution in this context. Physical climate sciences have developed approaches, among others, where variables that are reasonably sampled over climatically relevant time periods and related to the meteorological characteristics of the extreme event are examined. Trends in these variables (e.g. air or sea surface temperatures) are compared between observations and climate simulations with and without anthropogenic forcing. Generally, progress has been made in recent years in attribution of changes in the chance of some single extreme weather events to anthropogenic climate change but there remain important challenges. A different line of research is primarily concerned with losses related to the extreme weather events over time, using disaster databases. A growing consensus is that the increase in asset values and in exposure are main drivers of the strong increase of economic losses over the past several decades, and only a limited number of studies have found trends consistent with expectations from climate change. Here we propose a better integration of existing lines of research in detection and attribution of extreme weather events and disasters by applying a risk framework. Risk is thereby defined as a function of the probability of occurrence of an extreme weather event, and the associated consequences, with consequences being a function of the intensity of the physical weather event, the exposure and value of assets, and vulnerabilities. We have examined selected major extreme events and disasters, including superstorm Sandy in 2012, the Pakistan floods and the heat wave in Russia in 2010, the 2010 floods in Colombia and the 2011 floods in Australia. We systematically analyzed to what extent (anthropogenic) climate change may have contributed to intensity and frequency of the event, along with changes in the other risk variables, to eventually reach a more comprehensive understanding of the relative role of climate change in recent loss and damage of extreme weather events.

Risk attitudes and birth order.

PubMed

Krause, Philipp; Heindl, Johannes; Jung, Andreas; Langguth, Berthold; Hajak, Göran; Sand, Philipp G

2014-07-01

Risk attitudes play important roles in health behavior and everyday decision making. It is unclear, however, whether these attitudes can be predicted from birth order. We investigated 200 mostly male volunteers from two distinct settings. After correcting for multiple comparisons, for the number of siblings and for confounding by gender, ordinal position predicted perception of health-related risks among participants in extreme sports (p < .01). However, the direction of the effect contradicted Adlerian theory. Except for alcohol consumption, these findings extended to self-reported risk behavior. Together, the data call for a cautious stand on the impact of birth order on risk attitudes. © The Author(s) 2013.

Genome sequencing of a single tardigrade Hypsibius dujardini individual

PubMed Central

Arakawa, Kazuharu; Yoshida, Yuki; Tomita, Masaru

2016-01-01

Tardigrades are ubiquitous microscopic animals that play an important role in the study of metazoan phylogeny. Most terrestrial tardigrades can withstand extreme environments by entering an ametabolic desiccated state termed anhydrobiosis. Due to their small size and the non-axenic nature of laboratory cultures, molecular studies of tardigrades are prone to contamination. To minimize the possibility of microbial contaminations and to obtain high-quality genomic information, we have developed an ultra-low input library sequencing protocol to enable the genome sequencing of a single tardigrade Hypsibius dujardini individual. Here, we describe the details of our sequencing data and the ultra-low input library preparation methodologies. PMID:27529330

Genome sequencing of a single tardigrade Hypsibius dujardini individual.

PubMed

Arakawa, Kazuharu; Yoshida, Yuki; Tomita, Masaru

2016-08-16

Tardigrades are ubiquitous microscopic animals that play an important role in the study of metazoan phylogeny. Most terrestrial tardigrades can withstand extreme environments by entering an ametabolic desiccated state termed anhydrobiosis. Due to their small size and the non-axenic nature of laboratory cultures, molecular studies of tardigrades are prone to contamination. To minimize the possibility of microbial contaminations and to obtain high-quality genomic information, we have developed an ultra-low input library sequencing protocol to enable the genome sequencing of a single tardigrade Hypsibius dujardini individual. Here, we describe the details of our sequencing data and the ultra-low input library preparation methodologies.

Evanescent field Sensors Based on Tantalum Pentoxide Waveguides – A Review

PubMed Central

Schmitt, Katrin; Oehse, Kerstin; Sulz, Gerd; Hoffmann, Christian

2008-01-01

Evanescent field sensors based on waveguide surfaces play an important role where high sensitivity is required. Particularly tantalum pentoxide (Ta2O5) is a suitable material for thin-film waveguides due to its high refractive index and low attenuation. Many label-free biosensor systems such as grating couplers and interferometric sensors as well as fluorescence-based systems benefit from this waveguide material leading to extremely high sensitivity. Some biosensor systems based on Ta2O5 waveguides already took the step into commercialization. This report reviews the various detection systems in terms of limit of detection, the applications, and the suitable surface chemistry. PMID:27879731

[Refeeding syndrome in geriatric patients : A frequently overlooked complication].

PubMed

Wirth, Rainer; Diekmann, Rebecca; Fleiter, Olga; Fricke, Leonhardt; Kreilkamp, Annika; Modreker, Mirja Katrin; Marburger, Christian; Nels, Stefan; Schaefer, Rolf; Willschrei, Heinz-Peter; Volkert, Dorothee

2018-01-01

The refeeding syndrome is a life-threatening complication that can occur after initiation of a nutrition therapy in malnourished patients. If the risk factors and pathophysiology are known, the refeeding syndrome can effectively be prevented and treated, if recognized early. A slow increase of food intake and the close monitoring of serum electrolyte levels play an important role. Because the refeeding syndrome is not well known and the symptoms may vary extremely, this complication is poorly recognized, especially against the background of geriatric multimorbidity. This overview is intended to increase the awareness of the refeeding syndrome in the risk group of geriatric patients.

Ghrelin as a Survival Hormone.

PubMed

Mani, Bharath K; Zigman, Jeffrey M

2017-12-01

Ghrelin administration induces food intake and body weight gain. Based on these actions, the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using genetic mouse models have raised doubts about the role of the endogenous ghrelin system in mediating body weight homeostasis or obesity. However, this is not to say that the endogenous ghrelin system is not important metabolically or otherwise. Here we review an emerging concept in which the endogenous ghrelin system serves an essential function during extreme nutritional and psychological challenges to defend blood glucose, protect body weight, avoid exaggerated depression, and ultimately allow survival. Copyright © 2017 Elsevier Ltd. All rights reserved.

The pathogenesis of Ebola hemorrhagic fever.

PubMed

Takada, A; Kawaoka, Y

2001-10-01

Ebola virus causes lethal hemorrhagic disease in humans, yet there are still no satisfactory biological explanations to account for its extreme virulence. This review focuses on recent findings relevant to understanding the pathogenesis of Ebola virus infection and developing vaccines and effective therapy. The available data suggest that the envelope glycoprotein and the interaction of some viral proteins with the immune system are likely to play important roles in the extraordinary pathogenicity of this virus. There are also indications that genetically engineered vaccines, including plasmid DNA and viral vectors expressing Ebola virus proteins, and passive transfer of neutralizing antibodies could be feasible options for the control of Ebola virus-associated disease.

Measurement of trace stratospheric constituents with a balloon borne laser radar

NASA Technical Reports Server (NTRS)

Heaps, William S.; Mcgee, Thomas J.

1990-01-01

The objective of this research was to measure the concentration of the stratospheric hydroxyl radical and related chemical species as a function of altitude, season, and time of day. Although hydroxyl plays a very important role in the chemistry controlling stratospheric ozone, little is known about its behavior because it has been a difficult species to measure. The instrument employed in this program was a laser radar, employing the technique of remote laser induced fluorescence. This instrument offers a number of attractive features including extreme specificity and sensitivity, a straightforward relationship between observed quantity and the desired concentration, and immunity to self-contamination.

Purulent Pericarditis with Salmonella enterica Subspecies arizona in a Patient with Type 2 Diabetes Mellitus

PubMed Central

Suzuki, Ai; Tanaka, Takamitsu; Ohba, Kenji; Ito, Naomi; Sakai, Yuki; Kaneko, Akane; Machii, Masashi; Nonaka, Daishi; Goto, Yoshie; Takase, Hiroyuki

2017-01-01

Purulent pericarditis is a life-threatening disorder, even in the modern antibiotic era. Although diabetes mellitus is known to be associated with an increased risk of multiple types of infections, purulent pericarditis is extremely rare. We herein report an unusual case of pericarditis caused by Salmonella enterica subspecies arizona that was not associated with any evident underlying immunosuppressive disorder apart from uncontrolled type 2 diabetes mellitus. Because a pet snake was suspected as being the source of infection in the present case, patient education and a detailed review of exposure history could play an important role in treating patients with diabetes mellitus. PMID:28781305

The Power to Detect Linkage Disequilibrium with Quantitative Traits in Selected Samples

PubMed Central

Abecasis, Gonçalo R.; Cookson, William O. C.; Cardon, Lon R.

2001-01-01

Results from power studies for linkage detection have led to many ongoing and planned collections of phenotypically extreme nuclear families. Given the great expense of collecting these families and the imminent availability of a dense diallelic marker map, the families are likely to be used in allelic-association as well as linkage studies. However, optimal selection strategies for linkage may not be equally powerful for association. We examine the power to detect linkage disequilibrium for quantitative traits after phenotypic selection. The results encompass six selection strategies that are in widespread use, including single selection (two designs), affected sib pairs, concordant and discordant pairs, and the extreme-concordant and -discordant design. Selection of sibships on the basis of one extreme proband with high or low trait scores provides as much power as discordant sib pairs but requires the screening and phenotyping of substantially fewer initial families from which to select. Analysis of the role of allele frequencies within each selection design indicates that common trait alleles generally offer the most power, but similarities between the marker- and trait-allele frequencies are much more important than the trait-locus frequency alone. Some of the most widespread selection designs, such as single selection, yield power gains only when both the marker and quantitative trait loci (QTL) are relatively rare in the population. In contrast, discordant pairs and the extreme-proband design provide power for the broadest range of QTL–marker-allele frequency differences. Overall, proband selection from either tail provides the best balance of power, robustness, and simplicity of ascertainment for family-based association analysis. PMID:11349228

Effect of mirror therapy with tDCS on functional recovery of the upper extremity of stroke patients.

PubMed

Cho, Hyuk-Shin; Cha, Hyun-Gyu

2015-04-01

[Purpose] This study aimed to determine the effect of mirror therapy (MT) with transcranial direct current stimulation (tDCS) on the recovery of the upper extremity function of chronic stroke patients. [Subjects] Twenty-seven patients at least 6 months after stroke onset were divided randomly into an experimental group (14 patients) and a control group (13 patients). [Methods] All subjects received tDCS for 20 min followed by a 5 min rest. Then the experimental group received MT while the control group conducted the same exercises as the experimental group using a mirror that did not show the non-paretic upper extremity. The groups performed the same exercises for 20 min. All subjects received this intervention for 45-min three times a week for 6 weeks. [Results] After the intervention, the experimental group showed significant improvements in the box and block test (BBT), grip strength, and the Fugl-Meyer assessment (FMA), and a significant decrease in the Jebsen-Taylor test. The control group showed a significant increase in grip strength after the intervention, and a significant decrease in the Jebsen-Taylor test. Comparison of the result after the intervention revealed that the experimental group showed more significant increases in the BBT and grip strength than the control group. [Conclusion] These results show that MT with tDCS has a positive effect on the functional recovery of the upper extremity of stroke patients, through activating motor regions in the brain, and thus plays an important role in recovery of neuroplasticity.

Terminal Investment Strategies and Male Mate choice: Extreme Tests of Bateman.

PubMed

Andrade, Maydianne C B; Kasumovic, Michael M

2005-11-01

Bateman's principle predicts the intensity of sexual selection depends on rates of increase of fecundity with mating success for each sex (Bateman slopes). The sex with the steeper increase (usually males) is under more intense sexual selection and is expected to compete for access to the sex under less intense sexual selection (usually females). Under Bateman and modern refinements of his ideas, differences in parental investment are key to defining Bateman slopes and thus sex roles. Other theories predict sex differences in mating investment, or any expenditures that reduce male potential reproductive rate, can also control sex roles. We focus on sexual behaviour in systems where males have low paternal investment but frequently mate only once in their lifetimes, after which they are often killed by the female. Mating effort (=terminal investment) is high for these males, and many forms of investment theory might predict sex role reversal. We find no qualitative evidence for sex role reversal in a sample of spiders that show this extreme male investment pattern. We also present new data for terminally-investing redback spiders (Latrodectus hasselti). Bateman slopes are relatively steep for male redbacks, and, as predicted by Bateman, there is little evidence for role reversal. Instead, males are competitive and show limited choosiness despite wide variation in female reproductive value. This study supports the proposal that high male mating investment coupled with low parental investment may predispose males to choosiness but will not lead to role reversal. We support the utility of using Bateman slopes to predict sex roles, even in systems with extreme male mating investment.

Analysis of the dependence of extreme rainfalls

NASA Astrophysics Data System (ADS)

Padoan, Simone; Ancey, Christophe; Parlange, Marc

2010-05-01

The aim of spatial analysis is to quantitatively describe the behavior of environmental phenomena such as precipitation levels, wind speed or daily temperatures. A number of generic approaches to spatial modeling have been developed[1], but these are not necessarily ideal for handling extremal aspects given their focus on mean process levels. The areal modelling of the extremes of a natural process observed at points in space is important in environmental statistics; for example, understanding extremal spatial rainfall is crucial in flood protection. In light of recent concerns over climate change, the use of robust mathematical and statistical methods for such analyses has grown in importance. Multivariate extreme value models and the class of maxstable processes [2] have a similar asymptotic motivation to the univariate Generalized Extreme Value (GEV) distribution , but providing a general approach to modeling extreme processes incorporating temporal or spatial dependence. Statistical methods for max-stable processes and data analyses of practical problems are discussed by [3] and [4]. This work illustrates methods to the statistical modelling of spatial extremes and gives examples of their use by means of a real extremal data analysis of Switzerland precipitation levels. [1] Cressie, N. A. C. (1993). Statistics for Spatial Data. Wiley, New York. [2] de Haan, L and Ferreria A. (2006). Extreme Value Theory An Introduction. Springer, USA. [3] Padoan, S. A., Ribatet, M and Sisson, S. A. (2009). Likelihood-Based Inference for Max-Stable Processes. Journal of the American Statistical Association, Theory & Methods. In press. [4] Davison, A. C. and Gholamrezaee, M. (2009), Geostatistics of extremes. Journal of the Royal Statistical Society, Series B. To appear.

Bioactive Micronutrients in Coffee: Recent Analytical Approaches for Characterization and Quantification

PubMed Central

2014-01-01

Production of coffee beans is an important lifeline for the economy of several countries in Latin America, Africa, and Asia. The brew from this well sought for cash crop is readily consumed due to its good sensory qualities owing to the presence of many micronutrients. Some of these chemical compounds possess biological activities, including antiproliferative, antioxidant, and antimicrobial effects. Four representative groups of these micronutrients, namely, caffeine, chlorogenic acid, diterpenes, and trigonelline, play key roles in these bioactive effects of coffee. In order to guarantee the quality of coffee products and to protect consumer interest and safeguard their well-being, it is extremely important to employ sensitive and accurate analytical methods in the characterization and quantitative determination of these bioactive constituents. This review aims to present recent applications in this regard. PMID:24967266

Rejection of Bromide and Bromate Ions by a Ceramic Membrane

PubMed Central

Moslemi, Mohammadreza; Davies, Simon H.; Masten, Susan J.

2012-01-01

Abstract Effects of pH and the addition of calcium chloride (CaCl2) on bromate (BrO3−) and bromide (Br−) rejection by a ceramic membrane were investigated. Rejection of both ions increased with pH. At pH 8, the rejection of BrO3− and Br− was 68% and 63%, respectively. Donnan exclusion appears to play an important role in determining rejection of BrO3− and Br−. In the presence of CaCl2, rejection of BrO3− and Br− ions was greatly reduced, confirming the importance of electrostatic interactions in determining rejection of BrO3− and Br−. The effect of Ca2+ is so pronounced that in most natural waters, rejection of both BrO3− and Br− by the membrane would be extremely small. PMID:23236251

Climate Risk Management in the Anthropocene: From Basic Science to Decisionmaking and Back.

NASA Astrophysics Data System (ADS)

King, A.; Karoly, D. J.

2014-12-01

In this talk I will discuss studies our group has conducted to investigate the role of anthropogenic climate change in the heavy rains of 2010-2012 and the heat and drought of 2013. Using a range of methodologies based on coupled climate models from the CMIP5 archive and very large atmosphere-only ensembles from the Weather@Home Australia-New Zealand ensemble we have found increases in the likelihood of hot extremes, such as the summer of 2012/13 and individual record-breaking hot days within that summer. In contrast, studies of the precipitation extremes that occurred in the summer of 2011/12 found limited evidence for a substantial anthropogenic role in these events. I will also present briefly on avenues of research we are currently pursuing in the Australian community. These include investigating whether anthropogenic climate change has altered the likelihood of weather associated with bushfires and the implementation of perturbed physics in the Weather@Home ensemble to allow us to study the potential role of human-induced climate change on extreme rainfall events.

The CAULDRON game: Helping decision makers understand extreme weather event attribution

NASA Astrophysics Data System (ADS)

Walton, P.; Otto, F. E. L.

2014-12-01

There is a recognition from academics and stakeholders that climate science has a fundamental role to play in the decision making process, but too frequently there is still uncertainty about what, when, how and why to use it. Stakeholders suggest that it is because the science is presented in an inaccessible manner, while academics suggest it is because the stakeholders do not have the scientific knowledge to understand and apply the science appropriately. What is apparent is that stakeholders need support, and that there is an onus on academia to provide it. This support is even more important with recent developments in climate science, such as extreme weather event attribution. We are already seeing the impacts of extreme weather events around the world causing lost of life and damage to property and infrastructure with current research suggesting that these events could become more frequent and more intense. If this is to be the case then a better understanding of the science will be vital in developing robust adaptation and business planning. The use of games, role playing and simulations to aid learning has long been understood in education but less so as a tool to support stakeholder understanding of climate science. Providing a 'safe' space where participants can actively engage with concepts, ideas and often emotions, can lead to deep understanding that is not possible through more passive mechanisms such as papers and web sites. This paper reports on a game that was developed through a collaboration led by the Red Cross/Red Crescent, University of Oxford and University of Reading to help stakeholders understand the role of weather event attribution in the decision making process. The game has already been played successfully at a number of high profile events including COP 19 and the African Climate Conference. It has also been used with students as part of a postgraduate environmental management course. As well as describing the design principles of the game, the paper also evaluates the success of the game as well as future developments.

The importance of taste on dietary choice, behaviour and intake in a group of young adults.

PubMed

Kourouniotis, S; Keast, R S J; Riddell, L J; Lacy, K; Thorpe, M G; Cicerale, S

2016-08-01

The 'taste of food' plays an important role in food choice. Furthermore, foods high in fat, sugar and salt are highly palatable and associated with increased food consumption. Research exploring taste importance on dietary choice, behaviour and intake is limited, particularly in young adults. Therefore, in this study a total of 1306 Australian university students completed questionnaires assessing dietary behaviors (such as how important taste was on food choice) and frequency of food consumption over the prior month. Diet quality was also assessed using a dietary guideline index. Participants had a mean age of 20 ± 5 years, Body Mass Index (BMI) of 22 ± 3 kg/m(2), 79% were female and 84% Australian. Taste was rated as being a very or extremely important factor for food choice by 82% of participants. Participants who rated taste as highly important, had a poorer diet quality (p = 0.001) and were more likely to consume less fruit (p = 0.03) and vegetables (p = 0.05). Furthermore, they were significantly more likely to consume foods high in fat, sugar and salt, including chocolate and confectionary, cakes and puddings, sweet pastries, biscuits, meat pies, pizza, hot chips, potato chips, takeaway meals, soft drink, cordial and fruit juice (p = 0.001-0.02). They were also more likely to consider avoiding adding salt to cooking (p = 0.02) and adding sugar to tea or coffee (p = 0.01) as less important for health. These findings suggest that the importance individuals place on taste plays an important role in influencing food choice, dietary behaviors and intake. Copyright © 2016 Elsevier Ltd. All rights reserved.

Competencies of front-line managers in supported accommodation: issues for practice and future research.

PubMed

Clement, Tim; Bigby, Christine

2012-06-01

Front-line managers of supported accommodation for people with intellectual disability are assumed to have a key role in the realisation of outcomes for service users. Yet, their job has been little researched. A job analysis from Minnesota that identified 142 competencies required of effective front-line managers was used to examine what was expected of the equivalent position in Victoria, Australia. These competencies formed the basis of semistructured interviews with an extreme sample of 16 high-performing house supervisors and 5 more senior managers. Ninety-two percent of the original competences were retained, with changes in language and terminology to reflect the local context. Emergent findings highlighted the importance of house supervisors' "orientations." The findings support the proposition that the front-line manager's job is underpinned by core competencies and that the role merits further study. Issues of wider significance for human service organisations and researchers are discussed.

Prebiotic coordination chemistry: The potential role of transition-metal complexes in the chemical evolution

NASA Technical Reports Server (NTRS)

Beck, M.

1979-01-01

In approaching the extremely involved and complex problem of the origin of life, consideration of the coordination chemistry appeared not only as a possibility but as a necessity. The first model experiments appear to be promising because of prebiotic-type synthesis by means of transition-metal complexes. It is especially significant that in some instances various types of vitally important substances (nucleic bases, amino acids) are formed simultaneously. There is ground to hope that systematic studies in this field will clarify the role of transition-metal complexes in the organizatorial phase of chemical evolution. It is obvious that researchers working in the fields of the chemistry of cyano and carbonyl complexes, and of the catalytic effect of transition-metal complexes are best suited to study these aspects of the attractive and interesting problem of the origin of life.

Effects of alcohol on c-Myc protein in the brain

PubMed Central

Akinyeke, Tunde; Weber, Sydney J; Davenport, April T; Baker, Erich J; Daunais, James B; Raber, Jacob

2018-01-01

Alcoholism is a disorder categorized by significant impairment that is directly related to persistent and extreme use of alcohol. The effects of alcoholism on c-Myc protein expression in the brain have been scarcely studied. This is the first study to investigate the role of different characteristics of alcoholism in c-Myc protein levels in the brain. We analyzed c-Myc protein in the hypothalamus and amygdala from four different animal models of alcohol abuse. c-Myc protein was increased following alcohol exposure in acute, chronic and withdrawal models. We also observed increases in c-Myc protein exposure in animals that are genetically predisposed to alcohol and methamphetamine abuse. Lastly, c-Myc protein was increased in animals that were acutely exposed to methamphetamine when compared to control treated animals. These results suggest that in substance abuse c-Myc plays an important role in the brain’s response. PMID:27832980

Evidence for effects of weight on reproduction in women.

PubMed

Davies, Michael J

2006-05-01

Body weight, and its constituent components of fat mass and lean tissue, plays an important role modulating reproductive development and functioning. Body weight influences the timing of menarche and the capacity to achieve a pregnancy. The nature of this relationship appears to be some variant on a 'U' shape. Extremes in body weight are associated with infertility and a range of adverse outcomes for both mother and baby across the course of pregnancy and perinatal period. Whereas underweight is associated with poor fetal growth and elevated pregnancy loss, overweight is more strongly associated with diseases in pregnancy, pregnancy loss and stillbirth and high birth weight. An emerging area of interest is the role of obesity on fertility, and the intergenerational 'tracking' of high maternal body weight into the second and subsequent generations, resulting not only in an increased risk of metabolic disease, but also perturbed reproductive functioning in the offspring.

Shadow Labor: Work and Wages among Immigrant Hispanic Women in Durham, North Carolina.

PubMed

Flippen, Chenoa A

2016-07-01

Drawing on data collected in Durham, NC, this paper examines the forces shaping the labor supply and wages of immigrant Hispanic women in new destinations. The analysis evaluates the role of human capital and immigration characteristics (including legal status), family structure, and immigrant-specific labor market conditions, such as subcontracting, in shaping labor market outcomes. Findings indicate that the main determinants of labor supply among immigrant Hispanic women in Durham relate to family structure, with human capital playing a relatively minor role. Important variation is observed, however, in the degree of work-family conflict across occupations. For wages, human capital and immigration characteristics (including documentation) are more determinant than family structure. Results highlight the extremely precarious position of immigrant Hispanic women in Durham's low wage labor market, and multiple, overlapping sources of disadvantage, particularly relating to legal status and family structure.

Patellofemoral anatomy and biomechanics: current concepts

PubMed Central

ZAFFAGNINI, STEFANO; DEJOUR, DAVID; GRASSI, ALBERTO; BONANZINGA, TOMMASO; MUCCIOLI, GIULIO MARIA MARCHEGGIANI; COLLE, FRANCESCA; RAGGI, FEDERICO; BENZI, ANDREA; MARCACCI, MAURILIO

2013-01-01

The patellofemoral joint, due to its particular bone anatomy and the numerous capsuloligamentous structures and muscles that act dynamically on the patella, is considered one of the most complex joints in the human body from the biomechanical point of view. The medial patellofemoral ligament (MPFL) has been demonstrated to contribute 60% of the force that opposes lateral displacement of the patella, and MPFL injury results in an approximately 50% reduction in the force needed to dislocate the patella laterally with the knee extended. For this reason, recent years have seen a growing interest in the study of this important anatomical structure, whose aponeurotic nature has thus been demonstrated. The MPFL acts as a restraint during motion, playing an active role under conditions of laterally applied stress, but an only marginal role during natural knee flexion. However, it remains extremely difficult to clearly define the anatomy of the MPFL and its relationships with other anatomical structures. PMID:25606512

Shadow Labor: Work and Wages among Immigrant Hispanic Women in Durham, North Carolina

PubMed Central

Flippen, Chenoa A.

2017-01-01

Drawing on data collected in Durham, NC, this paper examines the forces shaping the labor supply and wages of immigrant Hispanic women in new destinations. The analysis evaluates the role of human capital and immigration characteristics (including legal status), family structure, and immigrant-specific labor market conditions, such as subcontracting, in shaping labor market outcomes. Findings indicate that the main determinants of labor supply among immigrant Hispanic women in Durham relate to family structure, with human capital playing a relatively minor role. Important variation is observed, however, in the degree of work-family conflict across occupations. For wages, human capital and immigration characteristics (including documentation) are more determinant than family structure. Results highlight the extremely precarious position of immigrant Hispanic women in Durham’s low wage labor market, and multiple, overlapping sources of disadvantage, particularly relating to legal status and family structure. PMID:28603290

The Role of Intrinsic Motivation and the Satisfaction of Basic Psychological Needs Under Conditions of Severe Resource Scarcity.

PubMed

van Egmond, Marieke Christina; Navarrete Berges, Andrés; Omarshah, Tariq; Benton, Jennifer

2017-06-01

An emerging field of research is beginning to examine the ways in which socioeconomic disparities affect emotional, cognitive, and social processes. In this study, we took a two-step approach to examining the role that resource scarcity plays in the predictive power of intrinsic motivation on school attendance, as well as its influence on the precursors of intrinsic motivation: the psychological needs of relatedness, autonomy, and competence. Results revealed that intrinsic motivation predicts school attendance even under conditions of extreme adversity. The satisfaction of the basic needs is more important for participants who are exposed to severe rather than mild levels of deprivation. Our findings illustrate ecological effects on the mechanism underlying goal-directed behavior. They provide evidence in favor of self-determination theory's depiction of humans as active, growth-oriented organisms and for the potential of psychological interventions to reduce poverty.

The role of fine needle aspiration cytology in medical-surgical missions.

PubMed

Reyes, Cesar V; Reyes, Elisa A

2009-01-01

To relate a 6-year, short-term experience of utilizing fine needle aspiration cytology (FNAC) during medical-surgical missions in the impoverished areas of the Philippines. FNAC is a simple, accurate, fast and economical procedure and requires the simplest devices to implement. During medical-surgical missions to the poorest areas in the Third World countries, where there is almost complete lack of tissue processing and frozen section evaluation, and scarcity of laboratory testing, FNAC becomes a practical technique to use. FNAC in these situations plays an important role as an alternative diagnostic modality to surgery. Our week-long mission experience for 6 different years of successful application of FNAC is described. While the mission volunteers have gained extremely rewarding experience in these limited mission works, FNAC has proven to be a very useful adjunct in the delivery of short-term health care during medical-surgical treatment even in a less-than-ideal setting.

Building community resilience to violent extremism through genuine partnerships.

PubMed

Ellis, B Heidi; Abdi, Saida

2017-04-01

What is community resilience in relation to violent extremism, and how can we build it? This article explores strategies to harness community assets that may contribute to preventing youth from embracing violent extremism, drawing from models of community resilience as defined in relation to disaster preparedness. Research suggests that social connection is at the heart of resilient communities and any strategy to increase community resilience must both harness and enhance existing social connections, and endeavor to not damage or diminish them. First, the role of social connection within and between communities is explored. Specifically, the ways in which social bonding and social bridging can diminish risk for violence, including violent extremism, is examined. Second, research on the role of social connection between communities and institutions or governing bodies (termed social linking) is described. This research is discussed in terms of how the process of government partnering with community members can both provide systems for early intervention for violent extremism, as well as strengthen bonding and bridging social networks and in this way contribute broadly to building community resilience. Finally, community-based participatory research, a model of community engagement and partnership in research, is presented as a road map for building true partnerships and community engagement. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Application of RFID technology-upper extremity rehabilitation training.

PubMed

Chen, Chih-Chen; Chen, Yu-Luen; Chen, Shih-Ching

2016-01-01

[Purpose] Upper extremity rehabilitation after an injury is very important. This study proposes radio frequency identification (RFID) technology to improve and enhance the effectiveness of the upper extremity rehabilitation. [Subjects and Methods] People use their upper extremities to conduct daily activities. When recovering from injuries, many patients neglect the importance of rehabilitation, which results in degraded function. This study recorded the training process using the traditional rehabilitation hand gliding cart with a RFID reader, RFID tags in the panel, and a servo host computer. [Results] Clinical evidence, time taken to achieve a full score, counts of missing the specified spots, and Brunnstrom stage of aided recovery, the proximal part of the upper extremity show that the RFID-based upper extremity training significantly and reduce negative impacts of the disability in daily life and activities. [Conclusion] This study combined a hand-gliding cart with an RFID reader, and when patients moved the cart, the movement could be observed via the activated RFID tags. The training data was collected and quantified for a better understanding of the recovery status of the patients. Each of the participating patients made progress as expected.

Climatic extremes improve predictions of spatial patterns of tree species

USGS Publications Warehouse

Zimmermann, N.E.; Yoccoz, N.G.; Edwards, T.C.; Meier, E.S.; Thuiller, W.; Guisan, Antoine; Schmatz, D.R.; Pearman, P.B.

2009-01-01

Understanding niche evolution, dynamics, and the response of species to climate change requires knowledge of the determinants of the environmental niche and species range limits. Mean values of climatic variables are often used in such analyses. In contrast, the increasing frequency of climate extremes suggests the importance of understanding their additional influence on range limits. Here, we assess how measures representing climate extremes (i.e., interannual variability in climate parameters) explain and predict spatial patterns of 11 tree species in Switzerland. We find clear, although comparably small, improvement (+20% in adjusted D2, +8% and +3% in cross-validated True Skill Statistic and area under the receiver operating characteristics curve values) in models that use measures of extremes in addition to means. The primary effect of including information on climate extremes is a correction of local overprediction and underprediction. Our results demonstrate that measures of climate extremes are important for understanding the climatic limits of tree species and assessing species niche characteristics. The inclusion of climate variability likely will improve models of species range limits under future conditions, where changes in mean climate and increased variability are expected.

Black swans, power laws, and dragon-kings: Earthquakes, volcanic eruptions, landslides, wildfires, floods, and SOC models

NASA Astrophysics Data System (ADS)

Sachs, M. K.; Yoder, M. R.; Turcotte, D. L.; Rundle, J. B.; Malamud, B. D.

2012-05-01

Extreme events that change global society have been characterized as black swans. The frequency-size distributions of many natural phenomena are often well approximated by power-law (fractal) distributions. An important question is whether the probability of extreme events can be estimated by extrapolating the power-law distributions. Events that exceed these extrapolations have been characterized as dragon-kings. In this paper we consider extreme events for earthquakes, volcanic eruptions, wildfires, landslides and floods. We also consider the extreme event behavior of three models that exhibit self-organized criticality (SOC): the slider-block, forest-fire, and sand-pile models. Since extrapolations using power-laws are widely used in probabilistic hazard assessment, the occurrence of dragon-king events have important practical implications.

Towards Increased Engagement of Geoscientists in Global Development Frameworks

NASA Astrophysics Data System (ADS)

Gill, Joel

2016-04-01

Geoscientists have the potential to make a significant contribution to tackling some of the major socio-environmental challenges of today, including extreme poverty, sustainable development, disaster risk reduction and climate change. This presentation explores the importance and social responsibility of geoscientists to engage in such work through understanding and supporting key global development frameworks. During 2015 the international community agreed three important agendas for change. Each framework relates to the intersection of environmental processes with human activities and behaviours, addressing significant challenges affecting society. The frameworks are (i) the UN Global Goals for Sustainable Development, (ii) the Sendai Framework for Disaster Risk Reduction 2015-2030, and (iii) subject to final confirmation at the time of writing, an agreement on climate change at the Paris Conference of the Parties - COP21. The UN Global Goals for Sustainable Development, for example, includes 17 goals aiming to end extreme poverty, fight inequality and ensure environmental sustainability. Specific goals relate to clean water and sanitation, clean and affordable energy, the development of resilient infrastructure, and the need for climate action. Given this context, here (i) a synthesis is presented of the role of geoscience in successfully achieving these major global development frameworks agreed in 2015, (ii) the ethical and social understanding that underpins effective engagement by geoscientists in the science-policy-practice interface is discussed, and (iii) this required ethical understanding is placed into the context of geoscience training and development needs. This approach demonstrates the importance of geoscientists from across all sectors and specialisms, engaging in the implementation, monitoring and evaluation of global development frameworks. It highlights the importance of a greater awareness and consideration of our ethical responsibilities in order to better support efforts to tackle major societal challenges.

Comparative evaluation of the IPCC AR5 CMIP5 versus the AR4 CMIP3 model ensembles for regional precipitation and their extremes over South America

NASA Astrophysics Data System (ADS)

Tolen, J.; Kodra, E. A.; Ganguly, A. R.

2011-12-01

The assertion that higher-resolution experiments or more sophisticated process models within the IPCC AR5 CMIP5 suite of global climate model ensembles improves precipitation projections over the IPCC AR4 CMIP3 suite remains a hypothesis that needs to be rigorously tested. The questions are particularly important for local to regional assessments at scales relevant for the management of critical infrastructures and key resources, particularly for the attributes of sever precipitation events, for example, the intensity, frequency and duration of extreme precipitation. Our case study is South America, where precipitation and their extremes play a central role in sustaining natural, built and human systems. To test the hypothesis that CMIP5 improves over CMIP3 in this regard, spatial and temporal measures of prediction skill are constructed and computed by comparing climate model hindcasts with the NCEP-II reanalysis data, considered here as surrogate observations, for the entire globe and for South America. In addition, gridded precipitation observations over South America based on rain gage measurements are considered. The results suggest that the utility of the next-generation of global climate models over the current generation needs to be carefully evaluated on a case-by-case basis before communicating to resource managers and policy makers.

White matter anisotropy in the ventral language pathway predicts sound-to-word learning success

PubMed Central

Wong, Francis C. K.; Chandrasekaran, Bharath; Garibaldi, Kyla; Wong, Patrick C. M.

2011-01-01

According to the dual stream model of auditory language processing, the dorsal stream is responsible for mapping sound to articulation while the ventral stream plays the role of mapping sound to meaning. Most researchers agree that the arcuate fasciculus (AF) is the neuroanatomical correlate of the dorsal steam, however, less is known about what constitutes the ventral one. Nevertheless two hypotheses exist, one suggests that the segment of the AF that terminates in middle temporal gyrus corresponds to the ventral stream and the other suggests that it is the extreme capsule that underlies this sound to meaning pathway. The goal of this study is to evaluate these two competing hypotheses. We trained participants with a sound-to-word learning paradigm in which they learned to use a foreign phonetic contrast for signaling word meaning. Using diffusion tensor imaging (DTI), a brain imaging tool to investigate white matter connectivity in humans, we found that fractional anisotropy in the left parietal-temporal region positively correlated with the performance in sound-to-word learning. In addition, fiber tracking revealed a ventral pathway, composed of the extreme capsule and the inferior longitudinal fasciculus, that mediated auditory comprehension. Our findings provide converging evidence supporting the importance of the ventral steam, an extreme capsule system, in the frontal-temporal language network. Implications for current models of speech processing will also be discussed. PMID:21677162

The role of land-climate interactions for the regional amplification of temperature extremes in climate projections

NASA Astrophysics Data System (ADS)

Seneviratne, S. I.; Vogel, M.; Zscheischler, J.; Schwingshackl, C.; Davin, E.; Gudmundsson, L.; Guillod, B.; Hauser, M.; Hirsch, A.; Hirschi, M.; Humphrey, V.; Thiery, W.

2017-12-01

Regional hot extremes are projected to increase more strongly than the global mean temperature, with substantially larger changes than 2°C even if global warming is limited to this level (Seneviratne et al. 2016). This presentation will highlight the processes underlying this behavior, which is strongly related to land-climate feedbacks (Vogel et al. 2017). The identified feedbacks are also affecting the occurrence probability of compound drought and heat events (Zscheischler and Seneviratne 2017), with high relevance for impacts on forest fire and agriculture production. Moreover, the responsible land processes strongly contribute to the inter-model spread in the projections, and can thus be used to derive observations-based constraints to reduce the uncertainty of projected changes in climate extremes. Finally, we will also discuss the role of soil moisture effects on carbon uptake and their relevance for projections, as well as the role of land use changes in affecting the identified feedbacks and projected changes in climate extremes. References: Seneviratne, S.I., M. Donat, A.J. Pitman, R. Knutti, and R.L. Wilby, 2016: Allowable CO2 emissions based on regional and impact-related climate targets. Nature, 529, 477-483, doi:10.1038/nature16542. Vogel, M.M., R. Orth, F. Cheruy, S. Hagemann, R. Lorenz, B.J.J.M. Hurk, and S.I. Seneviratne, 2017: Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks. Geophysical Research Letters, 44(3), 1511-1519, doi:10.1002/2016GL071235. Zscheischler, J., and S.I. Seneviratne, 2017: Dependence of drivers affects risks associated with compound events. Science Advances, 3(6), doi: 10.1126/sciadv.1700263

The role of extreme orbits in the global organization of periodic regions in parameter space for one dimensional maps

NASA Astrophysics Data System (ADS)

da Costa, Diogo Ricardo; Hansen, Matheus; Guarise, Gustavo; Medrano-T, Rene O.; Leonel, Edson D.

2016-04-01

We show that extreme orbits, trajectories that connect local maximum and minimum values of one dimensional maps, play a major role in the parameter space of dissipative systems dictating the organization for the windows of periodicity, hence producing sets of shrimp-like structures. Here we solve three fundamental problems regarding the distribution of these sets and give: (i) their precise localization in the parameter space, even for sets of very high periods; (ii) their local and global distributions along cascades; and (iii) the association of these cascades to complicate sets of periodicity. The extreme orbits are proved to be a powerful indicator to investigate the organization of windows of periodicity in parameter planes. As applications of the theory, we obtain some results for the circle map and perturbed logistic map. The formalism presented here can be extended to many other different nonlinear and dissipative systems.

Non-Gaussian statistics of extreme events in stimulated Raman scattering: The role of coherent memory and source noise

NASA Astrophysics Data System (ADS)

Monfared, Yashar E.; Ponomarenko, Sergey A.

2017-10-01

We explore theoretically and numerically extreme event excitation in stimulated Raman scattering in gases. We consider gas-filled hollow-core photonic crystal fibers as a particular system realization. We show that moderate amplitude pump fluctuations obeying Gaussian statistics lead to the emergence of heavy-tailed non-Gaussian statistics as coherent seed Stokes pulses are amplified on propagation along the fiber. We reveal the crucial role that coherent memory effects play in causing non-Gaussian statistics of the system. We discover that extreme events can occur even at the initial stage of stimulated Raman scattering when one can neglect energy depletion of an intense, strongly fluctuating Gaussian pump source. Our analytical results in the undepleted pump approximation explicitly illustrate power-law probability density generation as the input pump noise is transferred to the output Stokes pulses.

Hatching delays in great tits and blue tits in response to an extreme cold spell: a long-term study

NASA Astrophysics Data System (ADS)

Glądalski, Michał; Bańbura, Mirosława; Kaliński, Adam; Markowski, Marcin; Skwarska, Joanna; Wawrzyniak, Jarosław; Zieliński, Piotr; Bańbura, Jerzy

2018-04-01

Variation in ambient temperature affects various life stages of organisms. It has been suggested that climate change not only implies higher global temperatures but also more unpredictable weather and more frequent extreme weather events. Temperature has a major influence on the optimal laying-incubation-hatching dates of insectivorous passerines, because it poses energetic constraints and affects the timing of food abundance. We have been studying breeding characteristics of great tits Parus major and blue tits Cyanistes caeruleus in two areas, an urban parkland and a deciduous forest, around the city of Łódź since 2002. During the egg-laying period in 2017, both tit species at both study areas faced an unusual cold spell as reflected by a sudden decrease in the mean ambient temperature to ca. 2-3 °C for about 5 days, which caused mean hatching delays of up to 6 days. Since flexibility of behavior plays a major role in adjusting to unpredictable weather conditions, examining its limits may be an important goal for future research.

Extreme low temperature tolerance in woody plants

PubMed Central

Strimbeck, G. Richard; Schaberg, Paul G.; Fossdal, Carl G.; Schröder, Wolfgang P.; Kjellsen, Trygve D.

2015-01-01

Woody plants in boreal to arctic environments and high mountains survive prolonged exposure to temperatures below -40°C and minimum temperatures below -60°C, and laboratory tests show that many of these species can also survive immersion in liquid nitrogen at -196°C. Studies of biochemical changes that occur during acclimation, including recent proteomic and metabolomic studies, have identified changes in carbohydrate and compatible solute concentrations, membrane lipid composition, and proteins, notably dehydrins, that may have important roles in survival at extreme low temperature (ELT). Consideration of the biophysical mechanisms of membrane stress and strain lead to the following hypotheses for cellular and molecular mechanisms of survival at ELT: (1) Changes in lipid composition stabilize membranes at temperatures above the lipid phase transition temperature (-20 to -30°C), preventing phase changes that result in irreversible injury. (2) High concentrations of oligosaccharides promote vitrification or high viscosity in the cytoplasm in freeze-dehydrated cells, which would prevent deleterious interactions between membranes. (3) Dehydrins bind membranes and further promote vitrification or act stearically to prevent membrane–membrane interactions. PMID:26539202

The pH of chemistry assays plays an important role in monoclonal immunoglobulin interferences.

PubMed

Alberti, Michael O; Drake, Thomas A; Song, Lu

2015-12-01

Immunoglobulin paraproteins can interfere with multiple chemistry assays. We want to investigate the mechanisms of immunoglobulin interference. Serum samples containing paraproteins from the index patient and eight additional patients were used to investigate the interference with the creatinine and total protein assays on the Beckman Coulter AU5400/2700 analyzer, and to determine the effects of pH and ionic strength on the precipitation of different immunoglobulins in these patient samples. The paraprotein interference with the creatinine and total protein assays was caused by the precipitation of IgM paraprotein in the index patient's samples under alkaline assay conditions. At extremely high pH (12-13) and extremely low pH (1-2) and low ionic strength, paraprotein formed large aggregates in samples from the index patient but not from other patients. The pH and ionic strength are the key factors that contribute to protein aggregation and precipitation which interfere with the creatinine and total protein measurements on AU5400/2700. The different amino acid sequence of each monoclonal paraprotein will determine the pH and ionic strength at which the paraprotein will precipitate.

Thermally activated TRP channels: molecular sensors for temperature detection.

PubMed

Castillo, Karen; Diaz-Franulic, Ignacio; Canan, Jonathan; Gonzalez-Nilo, Fernando; Latorre, Ramon

2018-01-24

Temperature sensing is one of the oldest capabilities of living organisms, and is essential for sustaining life, because failure to avoid extreme noxious temperatures can result in tissue damage or death. A subset of members of the transient receptor potential (TRP) ion channel family is finely tuned to detect temperatures ranging from extreme cold to noxious heat, giving rise to thermoTRP channels. Structural and functional experiments have shown that thermoTRP channels are allosteric proteins, containing different domains that sense changes in temperature, among other stimuli, triggering pore opening. Although temperature-dependence is well characterized in thermoTRP channels, the molecular nature of temperature-sensing elements remains unknown. Importantly, thermoTRP channels are involved in pain sensation, related to pathological conditions. Here, we provide an overview of thermoTRP channel activation. We also discuss the structural and functional evidence supporting the existence of an intrinsic temperature sensor in this class of channels, and we explore the basic thermodynamic principles for channel activation. Finally, we give a view of their role in painful pathophysiological conditions.

Extreme Pressure Synergistic Mechanism of Bismuth Naphthenate and Sulfurized Isobutene Additives

NASA Astrophysics Data System (ADS)

Xu, Xin; Hu, Jianqiang; Yang, Shizhao; Xie, Feng; Guo, Li

A four-ball tester was used to evaluate the tribological performances of bismuth naphthenate (BiNap), sulfurized isobutene (VSB), and their combinations. The results show that the antiwear properties of BiNap and VSB are not very visible, but they possess good extreme pressure (EP) properties, particularly sulfur containing bismuth additives. Synergistic EP properties of BiNap with various sulfur-containing additives were investigated. The results indicate that BiNap exhibits good EP synergism with sulfur-containing additives. The surface analytical tools, such as X-ray photoelectron spectrometer (XPS) scanning electron microscope (SEM) and energy dispersive X-ray (EDX), were used to investigate the topography, composition contents, and depth profile of some typical elements on the rubbing surface. Smooth topography of wear scar further confirms that the additive showed good EP capacities, and XPS and EDX analyzes indicate that tribochemical mixed protective films composed of bismuth, bismuth oxides, sulfides, and sulfates are formed on the rubbing surface, which improves the tribological properties of lubricants. In particular, a large number of bismuth atoms and bismuth sulfides play an important role in improving the EP properties of oils.

Diversity in transcripts and translational pattern of stress proteins in marine extremophiles.

PubMed

Ambily Nath, I V; Loka Bharathi, P A

2011-03-01

Extremophiles occur in a diverse range of habitats, from the frigid waters of Antarctic to the superheated plumes of hydrothermal vents. Their in-depth study could provide important insights into the biochemical, ecological and evolutionary aspects of marine microbes. The cellular machinery of such extreme-lovers could be highly flexible to cope with such harsh environments. Extreme conditions of temperature, pressure, salinity, pH, oxidative stress, radiation, etc., above the physiological tolerance level can disrupt the natural conformation of proteins in the cell. The induction of stress proteins (heat/cold shock proteins/salt stress proteins/pressure-induced proteins) plays a vital role in the acclimatization of extremophiles. The present review focuses on the in vitro studies conducted on the transcripts and translational pattern of stress proteins in extremophiles. Though some proteins are unique, a commonality in stress resistance mechanism has been observed, for example, the universal occurrence of HSP60, 70 and the expression of metabolic and DNA repair proteins. The review highlights that among all the stressful conditions, salt/osmotic stress evokes the expression of highest number of transcripts/proteins while psychrophilic condition the least.

Reaction of Basaltic Materials under High-Fidelity Venus Surface Conditions using the Glenn Extreme Environment Rig: First Results

NASA Technical Reports Server (NTRS)

Radoman-Shaw, Brandon; Harvey, Ralph; Costa, Gustavo; Nakley, Leah Michelle; Jacobson, Nathan S.

2016-01-01

Both historical and current investigations of Venus suggest that atmosphererock interactions play a critical role in the evolution of its atmosphere and crust. We have begun a series of systematic experiments designed to further our understanding of atmosphere-driven weathering and secondary mineralization of basaltic materials that may be occurring on Venus today. Our experiments expose representative igneous phases (mineral, glasses and rocks) to a high-fidelity simulation of Venus surface conditions using the NASA Glenn Extreme Environment Rig (GEER) located at the NASA Glenn Research Center in Cleveland, Ohio. GEER is a very large (800L) vessel capable of producing a long-term, high fidelity simulation of both the physical conditions (750 K and 92 bar) and atmospheric chemistry (down to the ppb-level) asso-ciated with the Venusian surface. As of this writing we have just finished the first of several planned experiments: a 42-day exposure of selected mineral, rocks and volcanic glasses. Our goal is to identify and prioritize the reactions taking place and better our understanding of their importance in Venus' climate history.

Extremely high intracellular concentration of glucose-6-phosphate and NAD(H) in Deinococcus radiodurans.

PubMed

Yamashiro, Takumi; Murata, Kousaku; Kawai, Shigeyuki

2017-03-01

Deinococcus radiodurans is highly resistant to ionizing radiation and UV radiation, and oxidative stress caused by such radiations. NADP(H) seems to be important for this resistance (Slade and Radman, Microbiol Mol Biol Rev 75:133-191; Slade, Radman, Microbiol Mol Biol Rev 75:133-191, 2011), but the mechanism underlying the generation of NADP(H) or NAD(H) in D. radiodurans has not fully been addressed. Intracellular concentrations of NAD + , NADH, NADP + , and NADPH in D. radiodurans are also not determined yet. We found that cell extracts of D. radiodurans catalyzed reduction of NAD(P) + in vitro, indicating that D. radiodurans cells contain both enzymes and a high concentration of substrates for this activity. The enzyme and the substrate were attributed to glucose-6-phosphate dehydrogenase and glucose-6-phosphate of which intracellular concentration was extremely high. Unexpectedly, the intracellular concentration of NAD(H) was also much greater than that of NADP(H), suggesting some significant roles of NADH. These unusual features of this bacterium would shed light on a new aspect of physiology of this bacterium.

Local Climate Experts: The Influence of Local TV Weather Information on Climate Change Perceptions

PubMed Central

Bloodhart, Brittany; Maibach, Edward; Myers, Teresa; Zhao, Xiaoquan

2015-01-01

Individuals who identify changes in their local climate are also more likely to report that they have personally experienced global climate change. One way that people may come to recognize that their local climate is changing is through information provided by local TV weather forecasters. Using random digit dialing, 2,000 adult local TV news viewers in Virginia were surveyed to determine whether routine exposure to local TV weather forecasts influences their perceptions of extreme weather in Virginia, and their perceptions about climate change more generally. Results indicate that paying attention to TV weather forecasts is associated with beliefs that extreme weather is becoming more frequent in Virginia, which in turn is associated with stronger beliefs and concerns about climate change. These associations were strongest for individuals who trust their local TV weathercaster as a source of information about climate change, and for those who identify as politically conservative or moderate. The findings add support to the literature suggesting that TV weathercasters can play an important role in educating the public about climate change. PMID:26551357

Local Climate Experts: The Influence of Local TV Weather Information on Climate Change Perceptions.

PubMed

Bloodhart, Brittany; Maibach, Edward; Myers, Teresa; Zhao, Xiaoquan

2015-01-01

Individuals who identify changes in their local climate are also more likely to report that they have personally experienced global climate change. One way that people may come to recognize that their local climate is changing is through information provided by local TV weather forecasters. Using random digit dialing, 2,000 adult local TV news viewers in Virginia were surveyed to determine whether routine exposure to local TV weather forecasts influences their perceptions of extreme weather in Virginia, and their perceptions about climate change more generally. Results indicate that paying attention to TV weather forecasts is associated with beliefs that extreme weather is becoming more frequent in Virginia, which in turn is associated with stronger beliefs and concerns about climate change. These associations were strongest for individuals who trust their local TV weathercaster as a source of information about climate change, and for those who identify as politically conservative or moderate. The findings add support to the literature suggesting that TV weathercasters can play an important role in educating the public about climate change.

High Energy Interactions in Massive Binaries: An Application to a Most Mysterious Binary

NASA Technical Reports Server (NTRS)

Corcoran, Michael

2013-01-01

Extremely massive stars (50M and above) are exceedingly rare in the local Universe but are believed to have composed the entire first generation of stars, which lived fast, died young and left behind the first generation of black holes and set the stage for the formation of lower mass stars suitable to support life. There are significant uncertainties about how this happened (and how it still happens), mostly due to our poor knowledge of how stars change mass as they evolve. Extremely massive stars give mass back to the ISM via strong radiatively-driven winds and sometimes through sporadic eruptions of the most massive and brightest stars. Such mass loss plays an important role in the chemical and dynamical evolution of the local interstellar medium prior to the supernova explosion. Below we discuss how high energy thermal (and, in some cases, non-thermal) emission, along with modern simulations in 2 and 3 dimensions, can be used to help determine a physically realistic picture of mass loss in a well-studied, mysterious system.

An Investigation of Bomb Cyclogenesis in NCEP's CFS Model

NASA Astrophysics Data System (ADS)

Alvarez, F. M.; Eichler, T.; Gottschalck, J.

2008-12-01

With the concerns, impacts and consequences of climate change increasing, the need for climate models to simulate daily weather is very important. Given the improvements in resolution and physical parameterizations, climate models are becoming capable of resolving extreme weather events. A particular type of extreme event which has large impacts on transportation, industry and the general public is a rapidly intensifying cyclone referred to as a "bomb." In this study, bombs are investigated using the National Center for Environmental Prediction's (NCEP) Climate Forecast System (CFS) model. We generate storm tracks based on 6-hourly sea-level pressure (SLP) from long-term climate runs of the CFS model. Investigation of this dataset has revealed that the CFS model is capable of producing bombs. We show a case study of a bomb in the CFS model and demonstrate that it has characteristics similar to the observed. Since the CFS model is capable of producing bombs, future work will focus on trends in their frequency and intensity so that an assessment of the potential role of the bomb in climate change can be assessed.

Extreme events of perceived temperature over Europe: a projected northward extension of dangerous areas

NASA Astrophysics Data System (ADS)

Scoccimarro, Enrico; Fogli, Pier Giuseppe; Gualdi, Silvio

2017-04-01

It is well known that an increase of temperature over Europe, both in terms of averages and extremes, is expected within the current century. In order to consider health impacts under warm conditions, it is important to take into account the combined effect of temperature and humidity on the human body. To this aim a basic index - the humindex - representative of the perceived temperature, under different scenarios and periods, has been investigated in this study. A very low concomitance of extreme temperature events and extreme humindex events is found over the present climate, reinforcing the importance to investigate not only extreme temperature and relative humidity future projections but also the combination of the two parameters. A set of 10-km resolution regional climate simulations provided within the EUR-11 EURO-CORDEX multi-model effort, demonstrates ability in representing the intense and extreme events of the humindex over the present climate and to be eligible as a tool to quantify future changes in geographical patterns of exposed areas over Europe. An enlargement of the domain subject to dangerous conditions is found since the middle of the current century, reaching 60 degrees North when considering really extreme events. The most significant increase in humindex extreme events is found when comparing the 2066-2095 projections under rcp8.5 scenario, to the 1966-2005 period: bearing in mind that changes in relative humidity may either amplify or offset the health effects of temperature extremes, a less pronounced projected reduction of relative humidity intensity in the Northern part of the European domain, associated to extreme temperature and humindex, makes Northern Europe the most prone region to a local increase of the humindex extremes.

Upper Extremity Amputations and Prosthetics

PubMed Central

Ovadia, Steven A.; Askari, Morad

2015-01-01

Upper extremity amputations are most frequently indicated by severe traumatic injuries. The location of the injury will determine the level of amputation. Preservation of extremity length is often a goal. The amputation site will have important implications on the functional status of the patient and options for prosthetic reconstruction. Advances in amputation techniques and prosthetic reconstructions promote improved quality of life. In this article, the authors review the principles of upper extremity amputation, including techniques, amputation sites, and prosthetic reconstructions. PMID:25685104

The Contribution of SPECT/CT in the Diagnosis of Stress Fracture of the Proximal Tibia.

PubMed

Okudan, Berna; Coşkun, Nazım; Arıcan, Pelin

2018-02-01

Stress fractures are injuries most commonly seen in the lower limbs and are usually caused by repetitive stress. While the distal and middle third of the tibia is the most frequent site for stress fractures (almost 50%), stress fractures of the proximal tibia is relatively rare and could be confused with other types of tibial fractures, thus altering management plans for the clinician. Early diagnosis of stress fractures is also important to avoid complications. Imaging plays an important role in the diagnosis of stress fractures, especially bone scan. Combined with single-photon emission computed tomography/computed tomography (SPECT/CT) it is an important imaging technique for stress fractures in both upper and lower extremities, and is widely preferred over other imaging techniques. In this case, we present the case of a 39-year-old male patient diagnosed with stress fracture of the proximal tibia and demonstrate the contribution of CT scan fused with SPECT imaging in the early diagnosis of stress fracture prior to other imaging modalities.

Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?

PubMed

Gewin, Leslie S

2018-01-24

Wnt/β-catenin signaling is extremely important for proper kidney development. This pathway is also upregulated in injured renal tubular epithelia, both in acute kidney injury and chronic kidney disease. The renal tubular epithelium is an important target of kidney injury, and its response (repair versus persistent injury) is critical for determining whether tubulointerstitial fibrosis, the hallmark of chronic kidney disease, develops. This review discusses how Wnt/β-catenin signaling in the injured tubular epithelia promotes either repair or fibrosis after kidney injury. There is data suggesting that epithelial Wnt/β-catenin signaling is beneficial in acute kidney injury and important in tubular progenitors responsible for epithelial repair. The role of Wnt/β-catenin signaling in chronically injured epithelia is less clear. There is convincing data that Wnt/β-catenin signaling in interstitial fibroblasts and pericytes contributes to the extracellular matrix accumulation that defines fibrosis. However, some recent studies question whether Wnt/β-catenin signaling in chronically injured epithelia actually promotes fibrosis or repair.

Study on fracture identification of shale reservoir based on electrical imaging logging

NASA Astrophysics Data System (ADS)

Yu, Zhou; Lai, Fuqiang; Xu, Lei; Liu, Lin; Yu, Tong; Chen, Junyu; Zhu, Yuantong

2017-05-01

In recent years, shale gas exploration has made important development, access to a major breakthrough, in which the study of mud shale fractures is extremely important. The development of fractures has an important role in the development of gas reservoirs. Based on the core observation and the analysis of laboratory flakes and laboratory materials, this paper divides the lithology of the shale reservoirs of the XX well in Zhanhua Depression. Based on the response of the mudstone fractures in the logging curve, the fracture development and logging Response to the relationship between the conventional logging and electrical imaging logging to identify the fractures in the work, the final completion of the type of fractures in the area to determine and quantify the calculation of fractures. It is concluded that the fracture type of the study area is high and the microstructures are developed from the analysis of the XX wells in Zhanhua Depression. The shape of the fractures can be clearly seen by imaging logging technology to determine its type.

Delivery of growth factors for tissue regeneration and wound healing.

PubMed

Koria, Piyush

2012-06-01

Growth factors are soluble secreted proteins capable of affecting a variety of cellular processes important for tissue regeneration. Consequently, the self-healing capacity of patients can be augmented by artificially enhancing one or more processes important for healing through the application of growth factors. However, their application in clinics remains limited due to lack of robust delivery systems and biomaterial carriers. Interestingly, all clinically approved therapies involving growth factors utilize some sort of a biomaterial carrier for growth factor delivery. This suggests that biomaterial delivery systems are extremely important for successful usage of growth factors in regenerative medicine. This review outlines the role of growth factors in tissue regeneration, and their application in both pre-clinical animal models of regeneration and clinical trials is discussed. Additionally, current status of biomaterial substrates and sophisticated delivery systems such as nanoparticles for delivery of exogenous growth factors and peptides in humans are reviewed. Finally, issues and possible future research directions for growth factor therapy in regenerative medicine are discussed.

Computational discovery of small open reading frames in Bacillus lehensis

NASA Astrophysics Data System (ADS)

Zainuddin, Nurhafizhoh; Illias, Rosli Md.; Mahadi, Nor Muhammad; Firdaus-Raih, Mohd

2015-09-01

Bacillus lehensis is a Gram-positive and endospore-forming alkalitolerant bacterial strain. In recent years there has been increasing interest in alkaliphilic bacteria and their ability to grow under extreme conditions as well as their ability to serve various important functions in industrial biology especially enzyme production. Small open reading frames (sORFs) have emerged as important regulators in various biological roles such as tumor progression, hormone signalling and stress response. Over the past decade, many biocomputational tools have been developed to predict genes in bacterial genomes. In this study, three softwares were used to predict sORF (≤ 80 aa) in B. lehensis by using whole genome sequence. We used comparative analysis to identify the sORFs in B. lehensis that conserved across all other bacterial genomes. We extended the analysis by doing the homology analysis against protein database. This study established the sORFs in B. lehensis that are conserved across bacteria which might has important biological function which still remain elusive in biological field.

Are recent severe floods in Xiang River basin of China linked with the increase extreme precipitation?

NASA Astrophysics Data System (ADS)

Cheng, L.; Du, J.

2015-12-01

The Xiang River, a main tributary of the Yangtze River, is subjected to high floods frequently in recent twenty years. Climate change, including abrupt shifts and fluctuations in precipitation is an important factor influencing hydrological extreme conditions. In addition, human activities are widely recognized as another reasons leading to high flood risk. With the effects of climate change and human interventions on hydrological cycle, there are several questions that need to be addressed. Are floods in the Xiang River basin getting worse? Whether the extreme streamflow shows an increasing tendency? If so, is it because the extreme rainfall events have predominant effect on floods? To answer these questions, the article detected existing trends in extreme precipitation and discharge using Mann-Kendall test. Continuous wavelet transform method was employed to identify the consistency of changes in extreme precipitation and discharge. The Pearson correlation analysis was applied to investigate how much degree of variations in extreme discharge can be explained by climate change. The results indicate that slightly upward trends can be detected in both extreme rainfalls and discharge in the upper region of Xiang River basin. For the most area of middle and lower river basin, the extreme rainfalls show significant positive trends, but the extreme discharge displays slightly upward trends with no significance at 90% confidence level. Wavelet transform analysis results illustrate that highly similar patterns of signal changes can be seen between extreme precipitation and discharge in upper section of the basin, while the changes in extreme precipitation for the middle and lower reaches do not always coincide with the extreme streamflow. The correlation coefficients of the wavelet transforms for the precipitation and discharge signals in most area of the basin pass the significance test. The conclusion may be drawn that floods in recent years are not getting worse in Xiang River basin. The similar signal patterns and positive correlation between extreme discharge and precipitation indicate that the variability of extreme precipitation has an important effect on extreme discharge of flood, although the intensity of human impacts in lower section of Xiang River basin has increased markedly.

Semistable extremal ground states for nonlinear evolution equations in unbounded domains

NASA Astrophysics Data System (ADS)

Rodríguez-Bernal, Aníbal; Vidal-López, Alejandro

2008-02-01

In this paper we show that dissipative reaction-diffusion equations in unbounded domains posses extremal semistable ground states equilibria, which bound asymptotically the global dynamics. Uniqueness of such positive ground state and their approximation by extremal equilibria in bounded domains is also studied. The results are then applied to the important case of logistic equations.

Spatial Tourist and Functional Diversity on the Volcanic Island of Gran Canaria

NASA Astrophysics Data System (ADS)

Gonda-Soroczyńska, Eleonora; Olczyk, Hanna

2017-10-01

The conducted research is focused on spatial, functional and landscape diversity, the existing tourist potential and the possibilities for further development of a small, volcanic island of Gran Canaria. The discussed island was compared against other islands of the Canarian archipelago (Lanzarote, Fuerteventura, Tenerife, La Palma, El Hierro). Similarly to the remaining Canary Islands, the economy of Gran Canaria is predominantly based on tourism (approx. 4,5-5,0 million tourists visit the Canary Island annually and approx. 2,8 million come to Gran Canaria). Additionally, Puerto de la Luz transhipment centre in Las Palmas plays a very important role because of the goods imported from overseas. It is one of the largest ports in Spain (it reloads almost 2 million containers per year) also being an important Atlantic refuelling station. Apart from tourism, an important role is played here by agriculture, primarily the cultivation of bananas and tomatoes, which represent the most significant export good of the archipelago. The conducted spatial research showed an extensive diversity. This situation is, to a great extent, influenced by the climate. The northern part is cooler and dominated by agriculture, whereas the southern one is much warmer and characterized by a well-developed tourism infrastructure. Site inspections performed out along the outer contour of the island resembling a circle. Numerous architectural and urban sketches, urban analyses and photographic documentation were made. Community surveys were carried out. For a researcher, it was extremely interesting to answer the questions whether Gran Canaria is different from the other Canary Islands, especially in the functional and landscape context, and if so what exactly these differences consist of. What is Gran Canaria in particular characterized by and what kind of role it plays in the economic sector of Spain?

Toying with Lives: The Scandalous Plight of China's Toy Workers.

ERIC Educational Resources Information Center

Senser, Robert A.

2002-01-01

Notes that about half of U.S. toys are made in China, mainly by young women who work extremely long shifts, 7 days a week, "amid sickening vapors and under draconian rules." Describes corporate codes of conduct, the role consumers can play in changing extremely poor working conditions, and the impact of international trade reforms.…

Extreme Response Style in Recurrent and Chronically Depressed Patients: Change with Antidepressant Administration and Stability during Continuation Treatment

ERIC Educational Resources Information Center

Peterson, Timothy J.; Feldman, Greg; Harley, Rebecca; Fresco, David M.; Graves, Lesley; Holmes, Avram; Bogdan, Ryan; Papakostas, George I.; Bohn, Laurie; Lury, R. Alana; Fava, Maurizio; Segal, Zindel V.

2007-01-01

The authors examined extreme response style in recurrently and chronically depressed patients, assessing its role in therapeutic outcome. During the acute phase, outpatients with major depressive disorder (N = 384) were treated with fluoxetine for 8 weeks. Remitted patients (n = 132) entered a continuation phase during which their fluoxetine dose…

On alternative q-Weibull and q-extreme value distributions: Properties and applications

NASA Astrophysics Data System (ADS)

Zhang, Fode; Ng, Hon Keung Tony; Shi, Yimin

2018-01-01

Tsallis statistics and Tsallis distributions have been attracting a significant amount of research work in recent years. Importantly, the Tsallis statistics, q-distributions have been applied in different disciplines. Yet, a relationship between some existing q-Weibull distributions and q-extreme value distributions that is parallel to the well-established relationship between the conventional Weibull and extreme value distributions through a logarithmic transformation has not be established. In this paper, we proposed an alternative q-Weibull distribution that leads to a q-extreme value distribution via the q-logarithm transformation. Some important properties of the proposed q-Weibull and q-extreme value distributions are studied. Maximum likelihood and least squares estimation methods are used to estimate the parameters of q-Weibull distribution and their performances are investigated through a Monte Carlo simulation study. The methodologies and the usefulness of the proposed distributions are illustrated by fitting the 2014 traffic fatalities data from The National Highway Traffic Safety Administration.

Failed Endotracheal Intubation and Adverse Outcomes Among Extremely Low Birth Weight Infants

PubMed Central

Wallenstein, Matthew B.; Birnie, Krista L.; Arain, Yassar H.; Yang, Wei; Yamada, Nicole K.; Huffman, Lynne C.; Palma, Jonathan P.; Chock, Valerie Y.; Shaw, Gary M.; Stevenson, David K.

2015-01-01

OBJECTIVE To quantify the importance of successful endotracheal intubation on the first attempt among extremely low birth weight (ELBW) infants who require resuscitation after delivery. STUDY DESIGN A retrospective chart review was conducted for all ELBW infants ≤1000 g born between January 2007 and May 2014 at a level IV neonatal intensive care unit. Infants were included if intubation was attempted during the first five minutes of life, or if intubation was attempted during the first 10 minutes of life with heart rate < 100. The primary outcome was death or neurodevelopmental impairment. The association between successful intubation on the first attempt and the primary outcome was assessed using multivariable logistic regression with adjustment for birth weight, gestational age, gender, and antenatal steroids. RESULTS The study sample included 88 ELBW infants. Forty-percent were intubated on the first attempt and 60% required multiple intubation attempts. Death or neurodevelopmental impairment occurred in 29% of infants intubated on the first attempt, compared to 53% of infants that required multiple attempts, adjusted odds ratio 0.4 (95% confidence interval 0.1 - 1.0), p < 0.05. CONCLUSION Successful intubation on the first attempt is associated with improved neurodevelopmental outcomes among ELBW infants. This study confirms the importance of rapid establishment of a stable airway in ELBW infants requiring resuscitation after birth and has implications for personnel selection and role assignment in the delivery room. PMID:26540244

Cobalamin Protection against Oxidative Stress in the Acidophilic Iron-oxidizing Bacterium Leptospirillum Group II CF-1

PubMed Central

Ferrer, Alonso; Rivera, Javier; Zapata, Claudia; Norambuena, Javiera; Sandoval, Álvaro; Chávez, Renato; Orellana, Omar; Levicán, Gloria

2016-01-01

Members of the genus Leptospirillum are aerobic iron-oxidizing bacteria belonging to the phylum Nitrospira. They are important members of microbial communities that catalyze the biomining of sulfidic ores, thereby solubilizing metal ions. These microorganisms live under extremely acidic and metal-loaded environments and thus must tolerate high concentrations of reactive oxygen species (ROS). Cobalamin (vitamin B12) is a cobalt-containing tetrapyrrole cofactor involved in intramolecular rearrangement reactions and has recently been suggested to be an intracellular antioxidant. In this work, we investigated the effect of the exogenous addition of cobalamin on oxidative stress parameters in Leptospirillum group II strain CF-1. Our results revealed that the external supplementation of cobalamin reduces the levels of intracellular ROSs and the damage to biomolecules, and also stimulates the growth and survival of cells exposed to oxidative stress exerted by ferric ion, hydrogen peroxide, chromate and diamide. Furthermore, exposure of strain CF-1 to oxidative stress elicitors resulted in the transcriptional activation of the cbiA gene encoding CbiA of the cobalamin biosynthetic pathway. Altogether, these data suggest that cobalamin plays an important role in redox protection of Leptospirillum strain CF-1, supporting survival of this microorganism under extremely oxidative environmental conditions. Understanding the mechanisms underlying the protective effect of cobalamin against oxidative stress may help to develop strategies to make biomining processes more effective. PMID:27242761

Cobalamin Protection against Oxidative Stress in the Acidophilic Iron-oxidizing Bacterium Leptospirillum Group II CF-1.

PubMed

Ferrer, Alonso; Rivera, Javier; Zapata, Claudia; Norambuena, Javiera; Sandoval, Álvaro; Chávez, Renato; Orellana, Omar; Levicán, Gloria

2016-01-01

Members of the genus Leptospirillum are aerobic iron-oxidizing bacteria belonging to the phylum Nitrospira. They are important members of microbial communities that catalyze the biomining of sulfidic ores, thereby solubilizing metal ions. These microorganisms live under extremely acidic and metal-loaded environments and thus must tolerate high concentrations of reactive oxygen species (ROS). Cobalamin (vitamin B12) is a cobalt-containing tetrapyrrole cofactor involved in intramolecular rearrangement reactions and has recently been suggested to be an intracellular antioxidant. In this work, we investigated the effect of the exogenous addition of cobalamin on oxidative stress parameters in Leptospirillum group II strain CF-1. Our results revealed that the external supplementation of cobalamin reduces the levels of intracellular ROSs and the damage to biomolecules, and also stimulates the growth and survival of cells exposed to oxidative stress exerted by ferric ion, hydrogen peroxide, chromate and diamide. Furthermore, exposure of strain CF-1 to oxidative stress elicitors resulted in the transcriptional activation of the cbiA gene encoding CbiA of the cobalamin biosynthetic pathway. Altogether, these data suggest that cobalamin plays an important role in redox protection of Leptospirillum strain CF-1, supporting survival of this microorganism under extremely oxidative environmental conditions. Understanding the mechanisms underlying the protective effect of cobalamin against oxidative stress may help to develop strategies to make biomining processes more effective.

Direct volume estimation without segmentation

NASA Astrophysics Data System (ADS)

Zhen, X.; Wang, Z.; Islam, A.; Bhaduri, M.; Chan, I.; Li, S.

2015-03-01

Volume estimation plays an important role in clinical diagnosis. For example, cardiac ventricular volumes including left ventricle (LV) and right ventricle (RV) are important clinical indicators of cardiac functions. Accurate and automatic estimation of the ventricular volumes is essential to the assessment of cardiac functions and diagnosis of heart diseases. Conventional methods are dependent on an intermediate segmentation step which is obtained either manually or automatically. However, manual segmentation is extremely time-consuming, subjective and highly non-reproducible; automatic segmentation is still challenging, computationally expensive, and completely unsolved for the RV. Towards accurate and efficient direct volume estimation, our group has been researching on learning based methods without segmentation by leveraging state-of-the-art machine learning techniques. Our direct estimation methods remove the accessional step of segmentation and can naturally deal with various volume estimation tasks. Moreover, they are extremely flexible to be used for volume estimation of either joint bi-ventricles (LV and RV) or individual LV/RV. We comparatively study the performance of direct methods on cardiac ventricular volume estimation by comparing with segmentation based methods. Experimental results show that direct estimation methods provide more accurate estimation of cardiac ventricular volumes than segmentation based methods. This indicates that direct estimation methods not only provide a convenient and mature clinical tool for cardiac volume estimation but also enables diagnosis of cardiac diseases to be conducted in a more efficient and reliable way.

Complex Evolutionary Dynamics of Massively Expanded Chemosensory Receptor Families in an Extreme Generalist Chelicerate Herbivore.

PubMed

Ngoc, Phuong Cao Thi; Greenhalgh, Robert; Dermauw, Wannes; Rombauts, Stephane; Bajda, Sabina; Zhurov, Vladimir; Grbić, Miodrag; Van de Peer, Yves; Van Leeuwen, Thomas; Rouzé, Pierre; Clark, Richard M

2016-12-14

While mechanisms to detoxify plant produced, anti-herbivore compounds have been associated with plant host use by herbivores, less is known about the role of chemosensory perception in their life histories. This is especially true for generalists, including chelicerate herbivores that evolved herbivory independently from the more studied insect lineages. To shed light on chemosensory perception in a generalist herbivore, we characterized the chemosensory receptors (CRs) of the chelicerate two-spotted spider mite, Tetranychus urticae, an extreme generalist. Strikingly, T. urticae has more CRs than reported in any other arthropod to date. Including pseudogenes, 689 gustatory receptors were identified, as were 136 degenerin/Epithelial Na+ Channels (ENaCs) that have also been implicated as CRs in insects. The genomic distribution of T. urticae gustatory receptors indicates recurring bursts of lineage-specific proliferations, with the extent of receptor clusters reminiscent of those observed in the CR-rich genomes of vertebrates or C. elegans Although pseudogenization of many gustatory receptors within clusters suggests relaxed selection, a subset of receptors is expressed. Consistent with functions as CRs, the genomic distribution and expression of ENaCs in lineage-specific T. urticae expansions mirrors that observed for gustatory receptors. The expansion of ENaCs in T. urticae to > 3-fold that reported in other animals was unexpected, raising the possibility that ENaCs in T. urticae have been co-opted to fulfill a major role performed by unrelated CRs in other animals. More broadly, our findings suggest an elaborate role for chemosensory perception in generalist herbivores that are of key ecological and agricultural importance. © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Freshwater bacteria are stoichiometrically flexible with a nutrient composition similar to seston

USGS Publications Warehouse

Cotner, James B.; Hall, Edward K.; Scott, J. Thad; Heldal, Mikal

2010-01-01

Although aquatic bacteria are assumed to be nutrient-rich, they out-compete other foodweb osmotrophs for nitrogen (N) and phosphorus (P) an apparent contradiction to resource ratio theory. This paradox could be resolved if aquatic bacteria were demonstrated to be nutrient-poor relative other portions of the planktonic food web. In a survey of >120 lakes in the upper Midwest of the USA, the nutrient content of bacteria was lower than previously reported and very similar to the Redfield ratio, with a mean biomass composition of 102:12:1 (C:N:P). Individual freshwater bacterial isolates grown under P-limiting and P-replete conditions had even higher C:P and N:P ratios with a mean community biomass composition ratio of 875C:179N:1P suggesting that individual strains can be extremely nutrient-poor, especially with respect to P. Cell-specific measurements of individual cells from one lake confirmed that low P content could be observed at the community level in natural systems with a mean biomass composition of 259C:69N:1P. Variability in bacterial stoichiometry is typically not recognized in the literature as most studies assume constant and nutrient-rich bacterial biomass composition. We present evidence that bacteria can be extremely P-poor in individual systems and in culture, suggesting that bacteria in freshwater ecosystems can either play a role as regenerators or consumers of inorganic nutrients and that this role could switch depending on the relationship between bacterial biomass stoichiometry and resource stoichiometry. This ability to switch roles between nutrient retention and regeneration likely facilitates processing of terrestrial organic matter in lakes and rivers and has important implications for a wide range of bacterially mediated biogeochemical processes.

The role of the subtropical North Atlantic water cycle in recent US extreme precipitation events

NASA Astrophysics Data System (ADS)

Li, Laifang; Schmitt, Raymond W.; Ummenhofer, Caroline C.

2018-02-01

The role of the oceanic water cycle in the record-breaking 2015 warm-season precipitation in the US is analyzed. The extreme precipitation started in the Southern US in the spring and propagated northward to the Midwest and the Great Lakes in the summer of 2015. This seasonal evolution of precipitation anomalies represents a typical mode of variability of US warm-season precipitation. Analysis of the atmospheric moisture flux suggests that such a rainfall mode is associated with moisture export from the subtropical North Atlantic. In the spring, excessive precipitation in the Southern US is attributable to increased moisture flux from the northwestern portion of the subtropical North Atlantic. The North Atlantic moisture flux interacts with local soil moisture which enables the US Midwest to draw more moisture from the Gulf of Mexico in the summer. Further analysis shows that the relationship between the rainfall mode and the North Atlantic water cycle has become more significant in recent decades, indicating an increased likelihood of extremes like the 2015 case. Indeed, two record-high warm-season precipitation events, the 1993 and 2008 cases, both occurred in the more recent decades of the 66 year analysis period. The export of water from the North Atlantic leaves a marked surface salinity signature. The salinity signature appeared in the spring preceding all three extreme precipitation events analyzed in this study, i.e. a saltier-than-normal subtropical North Atlantic in spring followed by extreme Midwest precipitation in summer. Compared to the various sea surface temperature anomaly patterns among the 1993, 2008, and 2015 cases, the spatial distribution of salinity anomalies was much more consistent during these extreme flood years. Thus, our study suggests that preseason salinity patterns can be used for improved seasonal prediction of extreme precipitation in the Midwest.

Survival in an extreme habitat: the roles of behaviour and energy limitation

NASA Astrophysics Data System (ADS)

Plath, Martin; Tobler, Michael; Riesch, Rüdiger; García de León, Francisco J.; Giere, Olav; Schlupp, Ingo

2007-12-01

Extreme habitats challenge animals with highly adverse conditions, like extreme temperatures or toxic substances. In this paper, we report of a fish ( Poecilia mexicana) inhabiting a limestone cave in Mexico. Several springs inside the cave are rich in toxic H2S. We demonstrate that a behavioural adaptation, aquatic surface respiration (ASR), allows for the survival of P. mexicana in this extreme, sulphidic habitat. Without the possibility to perform ASR, the survival rate of P. mexicana was low even at comparatively low H2S concentrations. Furthermore, we show that food limitation affects the survival of P. mexicana pointing to energetically costly physiological adaptations to detoxify H2S.

Lower extremity joint kinetics and lumbar curvature during squat and stoop lifting

PubMed Central

Hwang, Seonhong; Kim, Youngeun; Kim, Youngho

2009-01-01

Background In this study, kinematics and kinetics of the lower extremity joint and the lumbar lordosis during two different symmetrical lifting techniques(squat and stoop) were examined using the three-dimensional motion analysis. Methods Twenty-six young male volunteers were selected for the subjects in this study. While they lifted boxes weighing 5, 10 and 15 kg by both squat and stoop lifting techniques, their motions were captured and analyzed using the 3D motion analysis system which was synchronized with two forceplates and the electromyographic system. Joint kinematics was determined by the forty-three reflective markers which were attached on the anatomical locations based on the VICON Plug-in-Gait marker placement protocol. Joint kinetics was analyzed by using the inverse dynamics. Paired t-test and Kruskal-Wallis test was used to compare the differences of variables between two techniques, and among three different weights. Correlation coefficient was calculated to explain the role of lower limb joint motion in relation to the lumbar lordosis. Results There were not significant differences in maximum lumbar joint moments between two techniques. The hip and ankle contributed the most part of the support moment during squat lifting, and the knee flexion moment played an important role in stoop lifting. The hip, ankle and lumbar joints generated power and only the knee joint absorbed power in the squat lifting. The knee and ankle joints absorbed power, the hip and lumbar joints generated power in the stoop lifting. The bi-articular antagonist muscles' co-contraction around the knee joint during the squat lifting and the eccentric co-contraction of the gastrocnemius and the biceps femoris were found important for maintaining the straight leg during the stoop lifting. At the time of lordotic curvature appearance in the squat lifting, there were significant correlations in all three lower extremity joint moments with the lumbar joint. Differently, only the hip moment had significant correlation with the lumbar joint in the stoop lifting. Conclusion In conclusion, the knee extension which is prominent kinematics during the squat lifting was produced by the contributions of the kinetic factors from the hip and ankle joints(extensor moment and power generation) and the lumbar extension which is prominent kinematics during the stoop lifting could be produced by the contributions of the knee joint kinetic factors(flexor moment, power absorption, bi-articular muscle function). PMID:19183507

Lower extremity joint kinetics and lumbar curvature during squat and stoop lifting.

PubMed

Hwang, Seonhong; Kim, Youngeun; Kim, Youngho

2009-02-02

In this study, kinematics and kinetics of the lower extremity joint and the lumbar lordosis during two different symmetrical lifting techniques(squat and stoop) were examined using the three-dimensional motion analysis. Twenty-six young male volunteers were selected for the subjects in this study. While they lifted boxes weighing 5, 10 and 15 kg by both squat and stoop lifting techniques, their motions were captured and analyzed using the 3D motion analysis system which was synchronized with two forceplates and the electromyographic system. Joint kinematics was determined by the forty-three reflective markers which were attached on the anatomical locations based on the VICON Plug-in-Gait marker placement protocol. Joint kinetics was analyzed by using the inverse dynamics. Paired t-test and Kruskal-Wallis test was used to compare the differences of variables between two techniques, and among three different weights. Correlation coefficient was calculated to explain the role of lower limb joint motion in relation to the lumbar lordosis. There were not significant differences in maximum lumbar joint moments between two techniques. The hip and ankle contributed the most part of the support moment during squat lifting, and the knee flexion moment played an important role in stoop lifting. The hip, ankle and lumbar joints generated power and only the knee joint absorbed power in the squat lifting. The knee and ankle joints absorbed power, the hip and lumbar joints generated power in the stoop lifting. The bi-articular antagonist muscles' co-contraction around the knee joint during the squat lifting and the eccentric co-contraction of the gastrocnemius and the biceps femoris were found important for maintaining the straight leg during the stoop lifting. At the time of lordotic curvature appearance in the squat lifting, there were significant correlations in all three lower extremity joint moments with the lumbar joint. Differently, only the hip moment had significant correlation with the lumbar joint in the stoop lifting. In conclusion, the knee extension which is prominent kinematics during the squat lifting was produced by the contributions of the kinetic factors from the hip and ankle joints(extensor moment and power generation) and the lumbar extension which is prominent kinematics during the stoop lifting could be produced by the contributions of the knee joint kinetic factors(flexor moment, power absorption, bi-articular muscle function).

Using ensembles in water management: forecasting dry and wet episodes

NASA Astrophysics Data System (ADS)

van het Schip-Haverkamp, Tessa; van den Berg, Wim; van de Beek, Remco

2015-04-01

Extreme weather situations as droughts and extensive precipitation are becoming more frequent, which makes it more important to obtain accurate weather forecasts for the short and long term. Ensembles can provide a solution in terms of scenario forecasts. MeteoGroup uses ensembles in a new forecasting technique which presents a number of weather scenarios for a dynamical water management project, called Water-Rijk, in which water storage and water retention plays a large role. The Water-Rijk is part of Park Lingezegen, which is located between Arnhem and Nijmegen in the Netherlands. In collaboration with the University of Wageningen, Alterra and Eijkelkamp a forecasting system is developed for this area which can provide water boards with a number of weather and hydrology scenarios in order to assist in the decision whether or not water retention or water storage is necessary in the near future. In order to make a forecast for drought and extensive precipitation, the difference 'precipitation- evaporation' is used as a measurement of drought in the weather forecasts. In case of an upcoming drought this difference will take larger negative values. In case of a wet episode, this difference will be positive. The Makkink potential evaporation is used which gives the most accurate potential evaporation values during the summer, when evaporation plays an important role in the availability of surface water. Scenarios are determined by reducing the large number of forecasts in the ensemble to a number of averaged members with each its own likelihood of occurrence. For the Water-Rijk project 5 scenario forecasts are calculated: extreme dry, dry, normal, wet and extreme wet. These scenarios are constructed for two forecasting periods, each using its own ensemble technique: up to 48 hours ahead and up to 15 days ahead. The 48-hour forecast uses an ensemble constructed from forecasts of multiple high-resolution regional models: UKMO's Euro4 model,the ECMWF model, WRF and Hirlam. Using multiple model runs and additional post processing, an ensemble can be created from non-ensemble models. The 15-day forecast uses the ECMWF Ensemble Prediction System forecast from which scenarios can be deduced directly. A combination of the ensembles from the two forecasting periods is used in order to have the highest possible resolution of the forecast for the first 48 hours followed by the lower resolution long term forecast.

Sexuality and gender role in autism spectrum disorder: a case control study.

PubMed

Bejerot, Susanne; Eriksson, Jonna M

2014-01-01

The 'extreme male brain theory of autism' describes an extreme male pattern of cognitive traits defined as strong systemising abilities paired with empathising weaknesses in autism spectrum disorder. However, beyond these cognitive traits, clinical observations have suggested an ambiguous gender-typed pattern regarding several sexually dimorphic traits. The aim of the present study was to investigate if patterns of non-cognitive sexually dimorphic traits differed between the autism spectrum disorder and control groups. Fifty adults with autism spectrum disorder and intelligence within the normal range, and 53 neurotypical controls responded to questions on gender role, self-perceived gender typicality and gender identity, as well as sexuality. Measures used were a Swedish modification of the Bem Sex Role Inventory and questions on sexuality and gender designed for the purpose of this study. Our results showed that one common gender role emerged in the autism spectrum disorder group. Masculinity (e.g. assertiveness, leadership and competitiveness) was weaker in the autism spectrum disorder group than in the controls, across men and women. Self-perceived gender typicality did not differ between the groups but tomboyism and bisexuality were overrepresented amongst women with autism spectrum disorder. Lower libido was reported amongst both male and female participants with autism spectrum disorder compared with controls. We conclude that the extreme male patterns of cognitive functions in the autistic brain do not seem to extend to gender role and sexuality. A gender-atypical pattern for these types of characteristics is suggested in autism spectrum disorder.

Sexuality and Gender Role in Autism Spectrum Disorder: A Case Control Study

PubMed Central

Bejerot, Susanne; Eriksson, Jonna M.

2014-01-01

The ‘extreme male brain theory of autism’ describes an extreme male pattern of cognitive traits defined as strong systemising abilities paired with empathising weaknesses in autism spectrum disorder. However, beyond these cognitive traits, clinical observations have suggested an ambiguous gender-typed pattern regarding several sexually dimorphic traits. The aim of the present study was to investigate if patterns of non-cognitive sexually dimorphic traits differed between the autism spectrum disorder and control groups. Fifty adults with autism spectrum disorder and intelligence within the normal range, and 53 neurotypical controls responded to questions on gender role, self-perceived gender typicality and gender identity, as well as sexuality. Measures used were a Swedish modification of the Bem Sex Role Inventory and questions on sexuality and gender designed for the purpose of this study. Our results showed that one common gender role emerged in the autism spectrum disorder group. Masculinity (e.g. assertiveness, leadership and competitiveness) was weaker in the autism spectrum disorder group than in the controls, across men and women. Self-perceived gender typicality did not differ between the groups but tomboyism and bisexuality were overrepresented amongst women with autism spectrum disorder. Lower libido was reported amongst both male and female participants with autism spectrum disorder compared with controls. We conclude that the extreme male patterns of cognitive functions in the autistic brain do not seem to extend to gender role and sexuality. A gender-atypical pattern for these types of characteristics is suggested in autism spectrum disorder. PMID:24498228

Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores.

PubMed

Gómez-Sánchez, Rubén; Rose, Jaqueline; Guimarães, Rodrigo; Mari, Muriel; Papinski, Daniel; Rieter, Ester; Geerts, Willie J; Hardenberg, Ralph; Kraft, Claudine; Ungermann, Christian; Reggiori, Fulvio

2018-05-30

The autophagy-related (Atg) proteins play a key role in the formation of autophagosomes, the hallmark of autophagy. The function of the cluster composed by Atg2, Atg18, and transmembrane Atg9 is completely unknown despite their importance in autophagy. In this study, we provide insights into the molecular role of these proteins by identifying and characterizing Atg2 point mutants impaired in Atg9 binding. We show that Atg2 associates to autophagosomal membranes through lipid binding and independently from Atg9. Its interaction with Atg9, however, is key for Atg2 confinement to the growing phagophore extremities and subsequent association of Atg18. Assembly of the Atg9-Atg2-Atg18 complex is important to establish phagophore-endoplasmic reticulum (ER) contact sites. In turn, disruption of the Atg2-Atg9 interaction leads to an aberrant topological distribution of both Atg2 and ER contact sites on forming phagophores, which severely impairs autophagy. Altogether, our data shed light in the interrelationship between Atg9, Atg2, and Atg18 and highlight the possible functional relevance of the phagophore-ER contact sites in phagophore expansion. © 2018 Gómez-Sánchez et al.

Vision rehabilitation for visual-vestibular dysfunction: the role of the neuro-optometrist.

PubMed

Cohen, Allen H

2013-01-01

This article discusses, in a clinically relevant format, the importance of including a neuro-optometrist as a member of the management team for patients with balance disorders. To review the importance of vision and visual processing for maintaining a sense of balance and equilibrium and the role of the neuro-optometrist in the overall rehabilitation of patients with balance disorders Dizziness, balance problems and the sensation that the space world is moving (vertigo) are one of the most commonly reported problems in general medical practice. Persons with a central nervous system injury or other idiopathic causes of visual processing problems or who have functional vision problems that are not adequately managed, often experience extreme difficulty with balance and movement, as well as with their perception of space. Consequently, the patient often experiences difficulty functioning in an environment with excessive visual stimulation such as a grocery store or shopping mall. Symptoms of disequilibrium, vestibular and balance problems are commonly a result of VOR disturbance secondary to an inner ear problem and an unstable binocularity. The combination of neuro-optomertic rehabilitative therapy and balance therapy will result in a is an effective treatment for reducing or resolving these symptoms.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warnecke, Falk; Warnecke, Falk; Luginbuhl, Peter

From the standpoints of both basic research and biotechnology, there is considerable interest in reaching a clearer understanding of the diversity of biological mechanisms employed during lignocellulose degradation. Globally, termites are an extremely successful group of wood-degrading organisms and are therefore important both for their roles in carbon turnover in the environment and as potential sources of biochemical catalysts for efforts aimed at converting wood into biofuels. Only recently have data supported any direct role for the symbiotic bacteria in the gut of the termite in cellulose and xylan hydrolysis. Here we use a metagenomic analysis of the bacterial communitymore » resident in the hindgut paunch of a wood-feeding Nasutitermes species to show the presence of a large, diverse set of bacterial genes for cellulose and xylan hydrolysis. Many of these genes were expressed in vivo or had cellulase activity in vitro, and further analyses implicate spirochete and fibrobacter species in gut lignocellulose degradation. New insights into other important symbiotic functions including H{sub 2} metabolism, CO{sub 2}-reductive acetogenesis and N{sub 2} fixation are also provided by this first system-wide gene analysis of a microbial community specialized towards plant lignocellulose degradation. Our results underscore how complex even a 1-{micro}l environment can be.« less

The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions

PubMed Central

Sacco, Antonio; Fenotti, Adriano; Affò, Loredana; Bazzana, Stefano; Russo, Domenico; Presta, Marco; Malagola, Michele; Anastasia, Antonella; Motta, Marina; Patterson, Christopher J.; Rossi, Giuseppe; Imberti, Luisa; Treon, Steven P.; Ghobrial, Irene M.; Roccaro, Aldo M.

2017-01-01

The Literature has recently reported on the importance of genomics in the field of hematologic malignancies, including B-cell lymphoproliferative disorders such as Waldenström's Macrolgobulinemia (WM). Particularly, whole exome sequencing has led to the identification of the MYD88L265P and CXCR4C1013G somatic variants in WM, occurring in about 90% and 30% of the patients, respectively. Subsequently, functional studies have demonstrated their functional role in supporting WM pathogenesis and disease progression, both in vitro and in vivo, thus providing the pre-clinical evidences for extremely attractive targets for novel therapeutic interventions in WM. Of note, recent evidences have also approached and defined the transcriptome profiling of WM cells, revealing a signature that mirrors the somatic aberrations demonstrated within the tumor clone. A parallel research field has also reported on microRNAs (miRNAs), highlighting the oncogenic role of miRNA-155 in WM. In the present review, we focus on the latest reports on genomics and miRNAs in WM, providing an overview of the clinical relevance of the latest acquired knowledge about genomics and miRNA aberrations in WM. PMID:28423722

The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions.

PubMed

Sacco, Antonio; Fenotti, Adriano; Affò, Loredana; Bazzana, Stefano; Russo, Domenico; Presta, Marco; Malagola, Michele; Anastasia, Antonella; Motta, Marina; Patterson, Christopher J; Rossi, Giuseppe; Imberti, Luisa; Treon, Steven P; Ghobrial, Irene M; Roccaro, Aldo M

2017-05-23

The Literature has recently reported on the importance of genomics in the field of hematologic malignancies, including B-cell lymphoproliferative disorders such as Waldenström's Macrolgobulinemia (WM). Particularly, whole exome sequencing has led to the identification of the MYD88L265P and CXCR4C1013G somatic variants in WM, occurring in about 90% and 30% of the patients, respectively. Subsequently, functional studies have demonstrated their functional role in supporting WM pathogenesis and disease progression, both in vitro and in vivo, thus providing the pre-clinical evidences for extremely attractive targets for novel therapeutic interventions in WM. Of note, recent evidences have also approached and defined the transcriptome profiling of WM cells, revealing a signature that mirrors the somatic aberrations demonstrated within the tumor clone. A parallel research field has also reported on microRNAs (miRNAs), highlighting the oncogenic role of miRNA-155 in WM. In the present review, we focus on the latest reports on genomics and miRNAs in WM, providing an overview of the clinical relevance of the latest acquired knowledge about genomics and miRNA aberrations in WM.

Theoretical study on the structure and stabilities of molecular clusters of oxalic acid with water.

PubMed

Weber, Kevin H; Morales, Francisco J; Tao, Fu-Ming

2012-11-29

The importance of aerosols to humankind is well-known, playing an integral role in determining Earth's climate and influencing human health. Despite this fact, much remains unknown about the initial events of nucleation. In this work, the molecular properties of common organic atmospheric pollutant oxalic acid and its gas phase interactions with water have been thoroughly examined. Local minima single-point energies for the monomer conformations were calculated at the B3LYP and MP2 level of theory with both 6-311++G(d,p) and aug-cc-pVDZ basis sets and are compared with previous works. Optimized geometries, relative energies, and free energy changes for the stable clusters of oxalic acid conformers with up to six waters were then obtained from B3LYP calculations with 6-31+G(d) and 6-311++G(d,p) basis sets. Initially, cooperative binding is predicted to be the most important factor in nucleation, but as the clusters grow, dipole cancellations are found to play a pivotal role. The clusters of oxalic acid hydrated purely with water tend to produce extremely stable and neutral core systems. Free energies of formation and atmospheric implications are discussed.

Quality versus quantity: The complexities of quality of life determinations for neonatal nurses.

PubMed

Green, Janet; Darbyshire, Philip; Adams, Anne; Jackson, Debra

2017-11-01

The ability to save the life of an extremely premature baby has increased substantially over the last decade. This survival, however, can be associated with unfavourable outcomes for both baby and family. Questions are now being asked about quality of life for survivors of extreme prematurity. Quality of life is rightly deemed to be an important consideration in high technology neonatal care; yet, it is notoriously difficult to determine or predict. How does one define and operationalise what is considered to be in the best interest of a surviving extremely premature baby, especially when the full extent of the outcomes might not be known for several years? The research investigates the caregiving dilemmas often faced by neonatal nurses when caring for extremely premature babies. This article explores the issues arising for neonatal nurses when they considered the philosophical and ethical questions about quality of life in babies ≤24 weeks gestation. Data were collected via a questionnaire to Australian neonatal nurses and semi-structured interviews with 24 neonatal nurses in New South Wales, Australia. Ethical considerations: Ethical processes and procedures have been adhered to by the researchers. A qualitative approach was used to analyse the data. The theme 'difficult choices' was generated which comprised three sub-themes: 'damaged through survival', 'the importance of the brain' and 'families are important'. The results show that neonatal nurses believed that quality of life was an important consideration; yet they experienced significant inner conflict and uncertainty when asked to define or suggest specific elements of quality of life, or to suggest how it might be determined. It was even more difficult for the nurses to say when an extremely premature baby's life possessed quality. Their previous clinical and personal experiences led the nurses to believe that the quality of the family's life was important, and possibly more so than the quality of life of the surviving baby. This finding contrasts markedly with much of the existing literature in this field. Quality of life for extremely premature babies was an important consideration for neonatal nurses; however, they experienced difficulty deciding how to operationalise such considerations in their everyday clinical practice.

Dependence of present and future European heat waves and cold spells on the location of atmospheric blocking

NASA Astrophysics Data System (ADS)

Brunner, L.; Schaller, N.; Sillmann, J.; Steiner, A. K.

2017-12-01

Atmospheric blocking describes stationary anti-cyclones, which weaken or reverse the climatological flow at mid-latitudes. In the northern hemisphere one of the main blocking regions is located over the North Atlantic and Northern Europe. The link between blocking and European temperature extremes, such as heat waves and cold spells, strongly depends on several aspects like season, longitudinal location of the block, and location of the extremes (particularly Northern Europe versus Southern Europe). We use a 50-member ensemble of the Canadian CanESM2 model to investigate historical (1981-2010) and future (2070-2099) blocking cases and their relationship with European temperature extremes. For the historical period the model results are also compared to those from the ERA-Interim reanalysis. Atmospheric blocking is detected on a daily basis in different 30° longitude windows between 60°W and 60°E, using a standard geopotential height-based detection index. Temperature extremes are defined by the daily Heat/Cold Wave Magnitude Index (HWMId/CWMId). The role of cold advection is found particularly important in winter conditions leading to a more than threefold increase in cold wave occurrence during blocking between 60°W and 0°. During blocking over Northern Europe (0° to 60°E) a split relationship is found with cold wave occurrence being strongly increased in Southern Europe, while it is decreased in Northern Europe. Direct, radiative effects dominate in summer, therefore blocking westward of Europe has a weaker effect, while blocking over Northern Europe leads to an increase of heat waves by at least a factor three at the location of the block and a decrease in cold wave occurrence in almost all of Europe. Comparing the historical and future period we find the link between blocking and temperature extremes in Europe to be robust, even though blocking frequency and temperatures are changing.

Extreme hydrometeorological events in the Peruvian Central Andes during austral summer and their relationship with the large-scale circulation

NASA Astrophysics Data System (ADS)

Sulca, Juan C.

In this Master's dissertation, atmospheric circulation patterns associated with extreme hydrometeorological events in the Mantaro Basin, Peruvian Central Andes, and their teleconnections during the austral summer (December-January-February-March) are addressed. Extreme rainfall events in the Mantaro basin are related to variations of the large-scale circulation as indicated by the changing strength of the Bolivian High-Nordeste Low (BH-NL) system. Dry (wet) spells are associated with a weakening (strengthening) of the BH-NL system and reduced (enhanced) influx of moist air from the lowlands to the east due to strengthened westerly (easterly) wind anomalies at mid- and upper-tropospheric levels. At the same time extreme rainfall events of the opposite sign occur over northeastern Brazil (NEB) due to enhanced (inhibited) convective activity in conjunction with a strengthened (weakened) Nordeste Low. Cold episodes in the Mantaro Basin are grouped in three types: weak, strong and extraordinary cold episodes. Weak and strong cold episodes in the MB are mainly associated with a weakening of the BH-NL system due to tropical-extratropical interactions. Both types of cold episodes are associated with westerly wind anomalies at mid- and upper-tropospheric levels aloft the Peruvian Central Andes, which inhibit the influx of humid air masses from the lowlands to the east and hence limit the potential for development of convective cloud cover. The resulting clear sky conditions cause nighttime temperatures to drop, leading to cold extremes below the 10-percentile. Extraordinary cold episodes in the MB are associated with cold and dry polar air advection at all tropospheric levels toward the central Peruvian Andes. Therefore, weak and strong cold episodes in the MB appear to be caused by radiative cooling associated with reduced cloudiness, rather than cold air advection, while the latter plays an important role for extraordinary cold episodes only.

European temperature responses to blocking and ridge regional patterns

NASA Astrophysics Data System (ADS)

Sousa, Pedro M.; Trigo, Ricardo M.; Barriopedro, David; Soares, Pedro M. M.; Santos, João A.

2018-01-01

Blocking occurrence and its impacts on European temperature have been studied in the last decade. However, most previous studies on blocking impacts have focused on winter only, disregarding its fingerprint in summer and differences with other synoptic patterns that also trigger temperature extremes. In this work, we provide a clear distinction between high-latitude blocking and sub-tropical ridges occurring in three sectors of the Euro-Atlantic region, describing their climatology and consequent impacts on European temperature during both winter and summer. Winter blocks (ridges) are generally associated to colder (warmer) than average conditions over large regions of Europe, in some areas with anomalies larger than 5 °C, particularly for the patterns occurring in the Atlantic and Central European sectors. During summer, there is a more regional response characterized by above average temperature for both blocking and ridge patterns, especially those occurring in continental areas, although negative temperature anomalies persist in southernmost areas during blocking. An objective analysis of the different forcing mechanisms associated to each considered weather regime has been performed, quantifying the importance of the following processes in causing the temperature anomalies: horizontal advection, vertical advection and diabatic heating. While during winter advection processes tend to be more relevant to explain temperature responses, in summer radiative heating under enhanced insolation plays a crucial role for both blocking and ridges. Finally, the changes in the distributions of seasonal temperature and in the frequencies of extreme temperature indices were also examined for specific areas of Europe. Winter blocking and ridge patterns are key drivers in the occurrence of regional cold and warm extreme temperatures, respectively. In summer, they are associated with substantial changes in the frequency of extremely warm days, but with different signatures in southern Europe. We conclude that there has been some misusage of the traditional blocking definition in the attribution of extreme events.

Free and total thyroid hormones in humans at extreme altitude

NASA Astrophysics Data System (ADS)

Basu, Minakshi; Pal, K.; Malhotra, A. S.; Prasad, R.; Sawhney, R. C.

1995-03-01

Alterations in circulatory levels of total T4 (TT4), total T3 (TT3), free T4 (FT4), free T3 (FT3), thyrotropin (TSH) and T3 uptake (T3U) were studied in male and female sea-level residents (SLR) at sea level, in Armed forces personnel staying at high altitude (3750 m) for prolonged duration (acclimatized lowlanders, ALL) and in high-altitude natives (HAN). Identical studies were also performed on male ALL who trekked to an extreme altitude of 5080 m and stayed at an altitude of more than 6300 m for about 6 months. The total as well as free thyroid hormones were found to be significantly higher in ALL and HAN as compared to SLR values. Both male as well as female HAN had higher levels of thyroid hormones. The rise in hormone levels in different ALL ethnic groups drawn from amongst the southern and northern parts of the country was more or less identical. In both HAN and ALL a decline in FT3 and FT4 occurred when these subjects trekked at subzero temperatures to extreme altitude of 5080 m but the levels were found to be higher in ALL who stayed at 6300 m for a prolonged duration. Plasma TSH did not show any appreciable change at lower altitudes but was found to be decreased at extreme altitude. The increase in thyroid hormones at high altitude was not due to an increase in hormone binding proteins, since T3U was found to be higher at high altitudes. A decline in TSH and hormone binding proteins and an increase in the free moiety of the hormones is indicative of a subtle degree of tissue hyperthyroidism which may be playing an important role in combating the extreme cold and hypoxic environment of high altitudes.

Spatially explicit scenario analysis for hydrologic services in an urbanizing agricultural watershed

NASA Astrophysics Data System (ADS)

Qiu, J.; Booth, E.; Carpenter, S. R.; Turner, M.

2013-12-01

The sustainability of hydrologic services (benefits to people generated by terrestrial ecosystem effects on freshwater) is challenged by changes in climate and land use. Despite the importance of hydrologic services, few studies have investigated how the provision of ecosystem services related to freshwater quantity and quality may vary in magnitude and spatial pattern for alternative future trajectories. Such analyses may provide useful information for sustaining freshwater resources in the face of a complex and uncertain future. We analyzed the supply of multiple hydrologic services from 2010 to 2070 across a large urbanizing agricultural watershed in the Upper Midwest of the United States, and asked the following: (i) What are the potential trajectories for the supply of hydrologic services under contrasting but plausible future scenarios? (ii) Where on the landscape is the delivery of hydrologic services most vulnerable to future changes? The Nested Watershed scenario represents extreme climate change (warmer temperatures and more frequent extreme events) and a concerted response from institutions, whereas in the Investment in Innovation scenario, climate change is less severe and technological innovations play a major role. Despite more extreme climate in the Nested Watershed scenario, all hydrologic services (i.e., freshwater supply, surface water quality, flood regulation) were maintained or enhanced (~30%) compared to the 2010 baseline, by strict government interventions that prioritized freshwater resources. Despite less extreme climate in the Investment in Innovation scenario and advances in green technology, only surface water quality and flood regulation were maintained or increased (~80%); freshwater supply declined by 25%, indicating a potential future tradeoff between water quality and quantity. Spatially, the locations of greatest vulnerability (i.e., decline) differed by service and among scenarios. In the Nested Watershed scenario, although freshwater supply and surface water quality were sustained or enhanced overall, these hydrologic services declined in ~60% and 20% of the landscape, respectively. The greatest improvement for most hydrologic services corresponded to areas of restored wetland, forest and perennial crops, which were less vulnerable to future degradation. In the Investment in Innovation scenario, freshwater supply declined in almost the entire watershed; improvement of surface water quality and flood regulation occurred mainly in urban areas, where highly engineered systems made them less vulnerable. Overall, our results indicated that hydrologic services will respond differently to future climate and land-use change, and sustaining one may involve tradeoffs of another. Technological progress can conserve particular services but might not be the panacea for the future. How society reacts in the face of changes can have an important role in determining the pathways to the future and the provision and spatial patterns of ecosystem services.

Educating Against Extremism: Towards a Critical Politicisation of Young People

NASA Astrophysics Data System (ADS)

Davies, Lynn

2009-05-01

This paper is based on a recently published book, Educating Against Extremism (Davies, Educating Against Extremism, 2008), which explores the potential role of schools in averting the more negative and violent forms of extremism in a country. It examines the nature of extremism; identity formation and radicalisation; religious belief, faith schools and the myth of equal value; justice, revenge and honour; and free speech, humour and satire. The paper argues that religious fundamentalism, as well as state terrorism, needs to be addressed in schools. The argument in the book is for a greater politicisation of young people through the forging of critical (dis)respect and the use of a secular basis of human rights. Specific forms of citizenship education are needed, which provide skills to analyse the media and political or religious messages, but also enable critical idealism to be fostered.

Emergence of Leadership within a Homogeneous Group

PubMed Central

Eskridge, Brent E.; Valle, Elizabeth; Schlupp, Ingo

2015-01-01

Large scale coordination without dominant, consistent leadership is frequent in nature. How individuals emerge from within the group as leaders, however transitory this position may be, has become an increasingly common question asked. This question is further complicated by the fact that in many of these aggregations, differences between individuals are minor and the group is largely considered to be homogeneous. In the simulations presented here, we investigate the emergence of leadership in the extreme situation in which all individuals are initially identical. Using a mathematical model developed using observations of natural systems, we show that the addition of a simple concept of leadership tendencies which is inspired by observations of natural systems and is affected by experience can produce distinct leaders and followers using a nonlinear feedback loop. Most importantly, our results show that small differences in experience can promote the rapid emergence of stable roles for leaders and followers. Our findings have implications for our understanding of adaptive behaviors in initially homogeneous groups, the role experience can play in shaping leadership tendencies, and the use of self-assessment in adapting behavior and, ultimately, self-role-assignment. PMID:26226381

Emergence of Leadership within a Homogeneous Group.

PubMed

Eskridge, Brent E; Valle, Elizabeth; Schlupp, Ingo

2015-01-01

Large scale coordination without dominant, consistent leadership is frequent in nature. How individuals emerge from within the group as leaders, however transitory this position may be, has become an increasingly common question asked. This question is further complicated by the fact that in many of these aggregations, differences between individuals are minor and the group is largely considered to be homogeneous. In the simulations presented here, we investigate the emergence of leadership in the extreme situation in which all individuals are initially identical. Using a mathematical model developed using observations of natural systems, we show that the addition of a simple concept of leadership tendencies which is inspired by observations of natural systems and is affected by experience can produce distinct leaders and followers using a nonlinear feedback loop. Most importantly, our results show that small differences in experience can promote the rapid emergence of stable roles for leaders and followers. Our findings have implications for our understanding of adaptive behaviors in initially homogeneous groups, the role experience can play in shaping leadership tendencies, and the use of self-assessment in adapting behavior and, ultimately, self-role-assignment.

Prostanoids and their receptors that modulate dendritic cell-mediated immunity.

PubMed

Gualde, Norbert; Harizi, Hedi

2004-08-01

Dendritic cells (DC) are essential for the initiation of immune responses by capturing, processing and presenting antigens to T cells. In addition to their important role as professional APC, they are able to produce immunosuppressive and pro-inflammatory prostanoids from arachidonic acid (AA) by the action of cyclooxygenase (COX) enzymes. In an autocrine and paracrine fashion, the secreted lipid mediators subsequently modulate the maturation, cytokine production, Th-cell polarizing ability, chemokine receptor expression, migration, and apoptosis of these extremely versatile APC. The biological actions of prostanoids, including their effects on APC-mediated immunity and acute inflammatory responses, are exerted by G protein-coupled receptors on plasma membrane. Some COX metabolites act as anti-inflammatory lipid mediators by binding to nuclear receptors and modulating DC functions. Although the role of cytokines in DC function has been studied extensively, the effects of prostanoids on DC biology have only recently become the focus of investigation. This review summarizes the current knowledge about the role of prostanoids and their receptors in modulating DC function and the subsequent immune responses.

Atmospheric River Importance to Extratropical Climate and Hydrology

NASA Astrophysics Data System (ADS)

Nash, D.; Waliser, D. E.; Guan, B.; Ye, H.; Ralph, F. M.

2017-12-01

Atmospheric Rivers (ARs) are narrow, long, water vapor rich corridors of the atmosphere that are responsible for over 90% of the poleward moisture transport across mid-latitudes and into high latitudes. This suggests a crucial role for ARs in helping establish the extra-tropical atmospheric water budget and hydroclimate variability. However, the contribution of ARs to the extra-tropical atmospheric water budget has yet to be quantified, including impacts on water vapor transport and storage, and precipitation. This study characterizes the roles of AR related atmospheric transport on combined and individual atmospheric water budget variables over extratropical regions of both hemispheres based on MERRA2 reanalysis products during 1997-2014. Results show that poleward water vapor transport related to ARs is strongly related to changes in water vapor storage and especially precipitation in higher latitudes in both hemispheres, with the relationship dependent on averaging period. For example, for the annual cycle climatology, both AR transport and local evaporation support the variation in precipitation. However, on monthly time scales, the water budget at higher latitudes tends to be dominated by the balance between AR transport and precipitation. On pentad and daily time scales, AR transport is related to both precipitation and water vapor storage changes. These results indicate the important role of the episodic, extreme moisture transports associated with ARs in helping establish the high latitude water and energy cycles, and associated hydroclimate.

Multiaxial and thermomechanical fatigue considerations in damage tolerant design

NASA Technical Reports Server (NTRS)

Leese, G. E.; Bill, R. C.

1985-01-01

In considering damage tolerant design concepts for gas turbine hot section components, several challenging concerns arise: Complex multiaxial loading situations are encountered; Thermomechanical fatigue loading involving very wide temperature ranges is imposed on components; Some hot section materials are extremely anisotropic; and coatings and environmental interactions play an important role in crack propagation. The effects of multiaxiality and thermomechanical fatigue are considered from the standpoint of their impact on damage tolerant design concepts. Recently obtained research results as well as results from the open literature are examined and their implications for damage tolerant design are discussed. Three important needs required to advance analytical capabilities in support of damage tolerant design become readily apparent: (1) a theoretical basis to account for the effect of nonproportional loading (mechanical and mechanical/thermal); (2) the development of practical crack growth parameters that are applicable to thermomechanical fatigue situations; and (3) the development of crack growth models that address multiple crack failures.

Tunable cytotoxicity of rhodamine 6G via anion variations.

PubMed

Magut, Paul K S; Das, Susmita; Fernand, Vivian E; Losso, Jack; McDonough, Karen; Naylor, Brittni M; Aggarwal, Sita; Warner, Isiah M

2013-10-23

Chemotherapeutic agents with low toxicity to normal tissues are a major goal in cancer research. In this regard, the therapeutic activities of cationic dyes, such as rhodamine 6G, toward cancer cells have been studied for decades with observed toxicities toward normal and cancer cells. Herein, we report rhodamine 6G-based organic salts with varying counteranions that are stable under physiological conditions, display excellent fluorescence photostability, and more importantly have tunable chemotherapeutic properties. Our in vitro studies indicate that the hydrophobic compounds of this series allow production of nanoparticles which are nontoxic to normal cells and toxic to cancer cells. Furthermore, the anions, in combination with cations such as sodium, were observed to be nontoxic to both normal and cancer cells. To the best of our knowledge, this is the first demonstration that both the cation and anion play an extremely important and cooperative role in the antitumor properties of these compounds.

[Diversity of arbuscular mycorrhizal fungi in special habitats: a review].

PubMed

Li, Su-Mei; Wang, Yin-Qiao; Liu, Run-Jin

2013-11-01

Arbuscular mycorrhizal fungi (AMF) are one of the important components in ecosystems, which not only have the diversity in genetics, species composition, and function, but also have the diversity in distribution and habitat. AMF infect plant root, form mycorrhiza, and nourish as obligate biotroph symbiont, with strong ecological adaptability. They not only distribute in forest, prairie, and farm land, but also distribute in the special habitats with less plant species diversity, such as commercial greenhouse soil, saline-alkali soil, mining pollution land, petroleum-contaminated land, pesticide-polluted soil, desert, dry land, wetland, marsh, plateau, volcanic, cooler, and arctic tundra, composing a unique community structure and playing an important irreplaceable role in the physiological and ecological functions. This paper summarized the species diversity and mycorrhizal morphological features of AMF in special habitats, aimed to provide essential information for the further studies on the AMF in these special habitats and extreme environments.

Hemostasis and malignancy.

PubMed

Francis, J L; Biggerstaff, J; Amirkhosravi, A

1998-01-01

There is considerable evidence that the hemostatic system is involved in the growth and spread of malignant disease. There is an increased incidence of thromboembolic disease in patients with cancers and hemostatic abnormalities are extremely common in such patients. Antihemostatic agents have been successfully used to treat a variety of experimental tumors, and several clinical trials in humans have been initiated. Although metastasis is undoubtedly multifactorial, intravascular coagulation activation and peritumor fibrin deposition seem to be important. The mechanisms by which hemostatic activation facilitates the malignant process remain to be completely elucidated. Of central importance may be the presence on malignant cells of tissue factor and urokinase receptor. Recent studies have suggested that these proteins, and others, may be involved at several stages of metastasis, including the key event of neovascularization. Tissue factor, the principal initiator of coagulation, may have additional roles, outside of fibrin formation, that are central to the biology of some solid tumors.

[Adherence: definitions and measurement methods: characteristics of adherence to topical treatments].

PubMed

Halioua, B

2012-01-01

Taking into account topical treatment compliance is extremely important given its fundamental place in the dermatologist's armamentarium. After reviewing the definition of compliance, adherence, alliance, and clinical inertia, the direct methods used to measure compliance with a topical treatment (counting tubes administered, MEMS system performance, measuring circulating blood or urine rate of a medication or its metabolite, and observation of medication intake by a third party) and indirect methods (questioning the patient, the dermatologist's opinion) will be reviewed. The question of frequency, more important than compliance in cases of topical treatments compared to systemic treatments, has given rise to controversial opinions. Six factors related to topical treatment that play a role in therapeutic compliance can be cited: the perception of efficacy, the feeling of harmlessness, the treatment's simplicity, the treatment's duration, the galenic formulation, and the cost. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Examining personal values in extreme environment contexts: Revisiting the question of generalizability

NASA Astrophysics Data System (ADS)

Smith, N.; Sandal, G. M.; Leon, G. R.; Kjærgaard, A.

2017-08-01

Land-based extreme environments (e.g. polar expeditions, Antarctic research stations, confinement chambers) have often been used as analog settings for spaceflight. These settings share similarities with the conditions experienced during space missions, including confinement, isolation and limited possibilities for evacuation. To determine the utility of analog settings for understanding human spaceflight, researchers have examined the extent to which the individual characteristics (e.g., personality) of people operating in extreme environments can be generalized across contexts (Sandal, 2000) [1]. Building on previous work, and utilising new and pre-existing data, the present study examined the extent to which personal value motives could be generalized across extreme environments. Four populations were assessed; mountaineers (N =59), military personnel (N = 25), Antarctic over-winterers (N = 21) and Mars simulation participants (N = 12). All participants completed the Portrait Values Questionnaire (PVQ; Schwartz; 2) capturing information on 10 personal values. Rank scores suggest that all groups identified Self-direction, Stimulation, Universalism and Benevolence as important values and acknowledged Power and Tradition as being low priorities. Results from difference testing suggest the extreme environment groups were most comparable on Self-direction, Stimulation, Benevolence, Tradition and Security. There were significant between-group differences on five of the ten values. Overall, findings pinpointed specific values that may be important for functioning in challenging environments. However, the differences that emerged on certain values highlight the importance of considering the specific population when comparing results across extreme settings. We recommend that further research examine the impact of personal value motives on indicators of adjustment, group working, and performance. Information from such studies could then be used to aid selection and training processes for personnel operating in extreme settings, and in space.

Subcellular localization based comparative study on radioresistant bacteria: A novel approach to mine proteins involve in radioresistance.

PubMed

Vishambra, Divya; Srivastava, Malay; Dev, Kamal; Jaiswal, Varun

2017-08-01

Radioresistant bacteria (RRB) are among the most radioresistant organisms and has a unique role in evolution. Along with the evolutionary role, radioresistant organisms play important role in paper industries, bioremediation, vaccine development and possibility in anti-aging and anti-cancer treatment. The study of radiation resistance in RRB was mainly focused on cytosolic mechanisms such as DNA repair mechanism, cell cleansing activity and high antioxidant activity. Although it was known that protein localized on outer areas of cell play role in resistance towards extreme condition but the mechanisms/proteins localized on the outer area of cells are not studied for radioresistance. Considering the fact that outer part of cell is more exposed to radiations and proteins present in outer area of the cell may have role in radioresistance. Localization based comparative study of proteome from RRB and non-radio resistant bacteria was carried out. In RRB 20 unique proteins have been identified. Further domain, structural, and pathway analysis of selected proteins were carried out. Out of 20 proteins, 8 proteins were direct involvement in radioresistance and literature study strengthens this, however, 1 proteins had assumed relation in radioresistance. Selected radioresistant proteins may be helpful for optimal use of RRB in industry and health care. Copyright © 2017 Elsevier Ltd. All rights reserved.

Adjusting skewness and maximum 0.5 hour intensity in CLIGEN to improve extreme event and sub-daily intensity generation for assessing climate change impacts

USDA-ARS?s Scientific Manuscript database

Both measured data and GCM/RCM projections show an general increasing trend in extreme rainfall events as temperature rises in US. Proper simulation of extreme events is particularly important for assessing climate change impacts on soil erosion and hydrology. The objective of this paper is to fin...

Ethnic/racial misidentification in death: a problem which may distort suicide statistics.

PubMed

Andres, V R

1977-01-01

Since the majority of suicide studies are ex post facto studies of demographic data collected by pathologists anc coroner's investigators, the role of the forensic scientist in determining the accuracy of statistical analyses of death is extremely important. This paper discusses how two salient features of a decedent, surname and residence location, can be misleading in determining the ethnic/racial classification of the decreased. Because many Southern California Indians have Spanish Surnames and most do not reside on an Indian reservation it is shown that the suicide statistics may represent an over-estimation of actual Mexican-American suicidal deaths while simultaneously representing an under-estimation of the suicides among American Indians of the region.

Is ideology a risk factor for PTSD symptom severity among Israeli political evacuees?

PubMed

Oren, Lior; Possick, Chaya

2010-08-01

To study the role of ideology in situations of extreme stress, a research questionnaire, measuring posttraumatic stress disorder (PTSD), settlement ideology (the importance of Jewish settlement in Gaza), and type of evacuation was administered to 326 Jewish residents who were evacuated from Gaza settlements by the Israeli government. Forty percent of the participants met the criteria of probable PTSD. Forcibly evicted individuals reported higher levels of settlement ideology and higher levels of PTSD symptom severity compared to voluntarily evacuated individuals. Contrary to previous studies, ideology was found to be positively associated with PTSD symptom severity. The results are explained by the conservation of resources and terror management theories. Theoretical and practical implications are discussed.

Selenium contents in tobacco and main stream cigarette smoke determined using neutron activation analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sorak-Pokrajac, M.; Dermelj, M.; Slejkovec, Z.

In the domain of the essential trace elements, the role of selenium is extremely important. As one of the volatile elements it can be partly absorbed through the pulmonary system during smoking and transported to different organs of the body. Thus a knowledge of its concentration levels in various sorts of tobacco and in the smoke of commercial cigarettes, as well as in the same type of cigarettes from plants treated with selenium, is of interest for various research fields. The purpose of this contribution is to present reliable quantitative data on selenium contents in tobacco, soil, and main streammore » cigarette smoke, obtained by destructive neutron activation analysis.« less

Enemy deterrence in the recruitment strategy of a termite: Soldier-organized foraging in Nasutitermes costalis

PubMed Central

Traniello, James F. A.

1981-01-01

The nasute soldiers of the neotropical termite Nasutitermes costalis function as scouts by exploring new terrain for food in advance of the worker caste and regulate foraging activity by laying trails composed of sternal gland pheromone. Additional soldiers are at first recruited in large numbers, and subsequently workers appear as the pheromone concentration increases. The role of the nasutes in the organization of foraging is extremely unusual for the soldier caste in social insects and appears to be a component of a foraging/defense system that controls the recruitment of foragers and effectively deters attacks by ants, the most fierce and important predators of termites. PMID:16592995

[Packaging: the guarantee of medicinal quality].

PubMed

Chaumeil, J-C

2003-01-01

Primary packaging guarantees the pharmaceutical quality of the medicinal preparation received by the patient. Glass bottles containing parenteral solutions for example ensure that sterility, quality and optimal stability are preserved until administration. Recent innovations in materials research has lead to improvements in parenteral infusions. Multicompartmental bags, allowing extemporaneous mixtures without opening the container, constitute an extremely beneficial advance for the patient, allowing administration of mixtures with solutions and emulsions which would be unstable if stored. Metered dose pressurized inhalers are an excellent example of drug administration devices designed specifically to ensure quality and bioavailability. These examples illustrate the important role of primary packaging and demonstrate the usefulness of research and development in this area.

Chiral reagents in glycosylation and modification of carbohydrates.

PubMed

Wang, Hao-Yuan; Blaszczyk, Stephanie A; Xiao, Guozhi; Tang, Weiping

2018-02-05

Carbohydrates play a significant role in numerous biological events, and the chemical synthesis of carbohydrates is vital for further studies to understand their various biological functions. Due to the structural complexity of carbohydrates, the stereoselective formation of glycosidic linkages and the site-selective modification of hydroxyl groups are very challenging and at the same time extremely important. In recent years, the rapid development of chiral reagents including both chiral auxiliaries and chiral catalysts has significantly improved the stereoselectivity for glycosylation reactions and the site-selectivity for the modification of carbohydrates. These new tools will greatly facilitate the efficient synthesis of oligosaccharides, polysaccharides, and glycoconjugates. In this tutorial review, we will summarize these advances and highlight the most recent examples.

Possibility of pain reduction by dietary intervention in patients with advanced cancer.

PubMed

Kapała, Aleksandra; Lange, Ewa

2013-01-01

Pain in advanced cancer can have many causes, and they are not necessarily associated with the presence of cancer. Invalid daily food rations in terms of energy, nutritional value, and cooking techniques used can significantly impair quality of life, increase patients' pain and other somatic symptoms and aggravate malnutrition and cachexia. Basic dietary factors affecting the quality of life and severity of somatic symptoms are the nutritional value of the diet, the frequency of meals and their consistency, the presence of fiber, fat, sugars, lactose, gluten and nutraceuticals. Extremely important is the role of a team of specialists, that offers professional nutritional advice to the patients and their carers.

A Bright Future for Evolutionary Methods in Drug Design.

PubMed

Le, Tu C; Winkler, David A

2015-08-01

Most medicinal chemists understand that chemical space is extremely large, essentially infinite. Although high-throughput experimental methods allow exploration of drug-like space more rapidly, they are still insufficient to fully exploit the opportunities that such large chemical space offers. Evolutionary methods can synergistically blend automated synthesis and characterization methods with computational design to identify promising regions of chemical space more efficiently. We describe how evolutionary methods are implemented, and provide examples of published drug development research in which these methods have generated molecules with increased efficacy. We anticipate that evolutionary methods will play an important role in future drug discovery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Diagnostic Dilemmas and Cultural Diversity in Emergency Rooms

PubMed Central

Weaver, Charlotte; Sklar, David

1980-01-01

Language and cultural beliefs play an extremely important role in the interaction between patients from diverse cultural groups and physicians. Especially in emergency rooms, there are many dangers in missed communications. A patient from a foreign culture, especially one who does not speak English, often expresses symptoms in ways that are unfamiliar to many American physicians. Specific areas of cultural vulnerability can be identified for the major ethnic groups in the United States as they interact with the scientific medical system. A short review of folk medical beliefs and recommendations for improving diagnostic accuracy and treatment may assist emergency room staffs in offering care that is culturally acceptable to patients of diverse ethnic backgrounds. PMID:7347053

[Roles of sialic acids in sperm maturation and capacitation and sperm-egg recognition].

PubMed

Feng, Ying; Wang, Lin; Wu, Yi-Lun; Liu, Hong-Hua; Ma, Fang

2016-10-01

Sialic acids are a subset of nine-carbon alpha-keto aldonic acids involved in various biological functions. Sialic acid on the sperm surface is closely related to sperm maturation and capacitation and sperm-egg recognition, which makes sperm negatively charged to avoid accumulation and covers some antigenic determinants there to increase the survival rate of sperm in the female reproductive tract. The loss of sialic acids is an important factor mediating sperm capacitation. Moreover, the sialic acid at the extremity of the protein polymer is involved in signal identification in sperm-egg recognition. Here, we review the current understanding of sialic acids in sperm maturation and capacitation and sperm-egg recognition.

Plasma radome designed for the EMP effects defense

NASA Astrophysics Data System (ADS)

Li, Zhigang; Wang, Jiachun; Cheng, Li; Wang, Qichao

2016-11-01

Radar, as the main detection means, plays an extremely important role in modern warfare. However, it is easily attacked by the electromagnetic pulse (EMP) weapon. In order to defense the threat, a radome formed by plasma is designed. The plasma radome is used to protect the radar systems against EMP coupling through both `front door' and `back door'. What's more, the damage effects of EMP to the radar systems are analyzed, and the protection mechanism of plasma to EMP weapon is discussed. In addition, a simulation experiment is carried out to verify the feasibility of the plasma radome to defense against EMP. The results indicate that the structure performs well, which makes it a new method against EMP weapon.

Urine Cytology: Collection, Film Preparation, and Evaluation.

PubMed

Vap, Linda M; Shropshire, Sarah B

2017-01-01

Cytologic examination of the urine sediment in animals suspected of having urinary tract disease or lower urinary tract masses is one of the best means of distinguishing inflammation, infection, and neoplasia and can help determine if a positive dipstick result for hemoglobin/blood is due to hemorrhage or blood contamination. The quality of the specimen collection and handling plays an important role in the quality of results, the validity of interpretations, and selection of appropriate course of action. The method of sample collection aids localization of pathology. Air dry but do not heat fix, freeze, or expose films to formalin fumes, temperature extremes, or condensation. Copyright © 2016 Elsevier Inc. All rights reserved.

The Green Ocean Over the Amazon: Implications for Cloud Electrification

NASA Technical Reports Server (NTRS)

Williams, E.; Blakeslee, R.; Boccippio, D.; Arnold, James E. (Technical Monitor)

2001-01-01

A convective regime with distinct maritime characteristics (weak updraft, low CCN, prevalent coalescence and rainout, weak mixed phase reflectivity, low glaciation temperature, and little if any lightning) is documented over the Amazon basin of the South American continent, and dubbed the "green ocean". Radar, lightning, thermodynamic and AVHRR satellite observations are examined to shed light on the roles of updraft and aerosol in providing departures from the green ocean regime toward continental behavior. Extreme case studies are identified in which the updraft control is dominant and in which the aerosol control is dominant. The tentative conclusion gives importance to both updrafts and aerosol in shaping the electrification of tropical convection.

Identification of Atmospheric Blocking Events and its Influence on Temperature and Precipitation Extremes in Europe

NASA Astrophysics Data System (ADS)

Richling, Andy; Rust, Henning W.; Bissolli, Peter; Ulbrich, Uwe

2017-04-01

Atmospheric blocking plays a crucial role in climate variability in the mid-latitudes. Especially meteorological extremes like heatwaves, cold spells and droughts are often related to persistent and stationary blocking events. For climate monitoring it is important to identify and characterise such blocking events as well as to analyse the relationship between blockings and meteorological extremes in a quantitative way. In this study we identify atmospheric blocking events and analyse the influence on temperature and precipitation extremes with statistical models. For the detection of atmospheric blocking events, we apply modified 2-dimensional versions of commonly used blocking indices suggested by Tibaldi and Molteni (1990) as well as Masato et al. (2013) on daily fields of 500hPa geopotential heights of the Era-Interim reanalysis dataset. A result is a list of blocking events with a multidimensional index characterising area, intensity, location and duration and maps of these parameters, which are intended to be used operationally for regular climate diagnostics at the German Meteorological Service. In addition, relationships between grid-point-base blocking frequency, intensity and location parameters and the number of daily temperature/precipitation extremes based on the E-OBS gridded dataset are investigated using general linear models on a monthly time scale. The number of counts as well as probabilities of occurrence of daily extremes within a certain calendar month will be analysed in this framework. G. Masato, B. J. Hoskins, and T. Woollings. Winter and Summer Northern Hemisphere Blocking in CMIP5 Models. J. Climate, 26:7044-7059, 2013a. doi: http://dx.doi.org/10.1175/JCLI-D- 12-00466.1. G. Masato, B. J. Hoskins, and T. Woollings. Wave-Breaking Characteristics of Northern Hemi- sphere Winter Blocking: A Two-Dimensional Approach. J. Climate, 26:4535-4549, 2013b. doi: http://dx.doi.org/10.1175/JCLI-D-12-00240.1. S. Tibaldi and F. Molteni. On the operational predictability of blocking. Tellus, 42A:343-365, 1990. doi: 10.1034/j.1600-0870.1990.t01-2-00003.x.

Attribution of extreme events in the western US to human activities

NASA Astrophysics Data System (ADS)

Mera, R. J.

2015-12-01

A project to investigate the role of human activities on the changing nature of extreme events in the western US began as part of a CLIVAR-sponsored Postdocs Applying Climate Expertise (PACE) project. The climate institution was the Oregon State University and the application partner was the Oregon Department of Land Conservation and Development (DLCD). DLCD was interested in the changes in weather extremes in the Pacific Northwest, specifically extreme rainfall, flooding, and droughts. The project employs very large ensembles of regional model simulations through volunteer computing resources and allows for probabilistic event attribution (PEA), an important climate research technique. The model was found to have good representation of atmospheric rivers, a major source of extreme precipitation in the Pacific Northwest. The model domain also encompasses California and Nevada. One of the studies focused on attribution of extreme heat in relation to vulnerable populations in California's Central Valley, where heat waves have become progressively more severe due to increasing nighttime temperatures. Specifically, we found that that (1) simulations of the hottest summer days during the 2000s were twice as likely to occur using observed levels of greenhouse gases than in a counterfactual world without major human activities, (2) detrimental impacts of heat on public health-relevant variables, such as the number of days above 40°C, can be quantified and attributed to human activities using PEA, and (3) PEA can serve as a tool for addressing climate justice concerns of populations within developed nations. The research conducted through the PACE program has also provided a framework for a pioneering climate attribution study at the Union of Concerned Scientists (UCS). The UCS project takes advantage of new research that shows that nearly two-thirds of carbon pollution released into the atmosphere, reported as carbon dioxide equivalent with hundred-year global warming potentials, can be traced to carbon extracted from the Earth by a subset of producers of coal, oil, natural gas, and cement manufacturers. The approach for this study is to use superensembles of regional model simulations to explore the specific fractional attribution to emissions traceable to 90 major industrial carbon producers.

Are Extremes of Consumption in Eating Disorders Related to an Altered Balance between Reward and Inhibition?

PubMed

Wierenga, Christina E; Ely, Alice; Bischoff-Grethe, Amanda; Bailer, Ursula F; Simmons, Alan N; Kaye, Walter H

2014-01-01

The primary defining characteristic of a diagnosis of an eating disorder (ED) is the "disturbance of eating or eating-related behavior that results in the altered consumption or absorption of food" (DSM V; American Psychiatric Association, 2013). There is a spectrum, ranging from those who severely restrict eating and become emaciated on one end to those who binge and overconsume, usually accompanied by some form of compensatory behaviors, on the other. How can we understand reasons for such extremes of food consummatory behaviors? Recent work on obesity and substance use disorders has identified behaviors and neural pathways that play a powerful role in human consummatory behaviors. That is, corticostriatal limbic and dorsal cognitive neural circuitry can make drugs and food rewarding, but also engage self-control mechanisms that may inhibit their use. Importantly, there is considerable evidence that alterations of these systems also occur in ED. This paper explores the hypothesis that an altered balance of reward and inhibition contributes to altered extremes of response to salient stimuli, such as food. We will review recent studies that show altered sensitivity to reward and punishment in ED, with evidence of altered activity in corticostriatal and insula processes with respect to monetary gains or losses, and tastes of palatable foods. We will also discuss evidence for a spectrum of extremes of inhibition and dysregulation behaviors in ED supported by studies suggesting that this is related to top-down self-control mechanisms. The lack of a mechanistic understanding of ED has thwarted efforts for evidence-based approaches to develop interventions. Understanding how ED behavior is encoded in neural circuits would provide a foundation for developing more specific and effective treatment approaches.

[Effect of extremely low frequency magnetic field on glutathione in rat muscles].

PubMed

Ciejka, Elzbieta; Jakubowska, Ewa; Zelechowska, Paulina; Huk-Kolega, Halina; Kowalczyk, Agata; Goraca, Anna

2014-01-01

Free radicals (FR) are atoms, molecules or their fragments. Their excess leads to the development of oxidizing stress, the cause of many neoplastic, neurodegenerative and inflammatory diseases, and aging of the organism. Industrial pollution, tobacco smoke, ionizing radiation, ultrasound and magnetic field are the major FR exogenous sources. The low frequency magnetic field is still more commonly applied in the physical therapy. The aim of the presented study was to evaluate the effect of extremely low frequency magnetic field used in the magnetotherapy on the level of total glutathione, oxidized and reduced, and the redox state of the skeletal muscle cells, depending on the duration of exposure to magnetic field. The male rats, weight of 280-300 g, were randomly devided into 3 experimental groups: controls (group I) and treatment groups exposed to extremely low frequency magnetic field (ELF-MF) (group II exposed to 40 Hz, 7 mT for 0.5 h/day for 14 days and group III exposed to 40 Hz, 7 mT for 1 h/day for 14 days). Control rats were kept in a separate room not exposed to extremely low frequency magnetic field. Immediately after the last exposure, part of muscles was taken under pentobarbital anesthesia. Total glutathione, oxidized and reduced, and the redox state in the muscle tissue of animals were determined after exposure to magnetic fields. Exposure to low magnetic field: 40 Hz, 7 mT for 30 min/day and 60 min/day for 2 weeks significantly increased the total glutathione levels in the skeletal muscle compared to the control group (p < 0.001). Exposure to magnetic fields used in the magnetic therapy plays an important role in the development of adaptive mechanisms responsible for maintaining the oxidation-reduction balance in the body and depends on exposure duration.

Extreme storm surge modelling in the North Sea. The role of the sea state, forcing frequency and spatial forcing resolution

NASA Astrophysics Data System (ADS)

Ridder, Nina; de Vries, Hylke; Drijfhout, Sybren; van den Brink, Henk; van Meijgaard, Erik; de Vries, Hans

2018-02-01

This study shows that storm surge model performance in the North Sea is mostly unaffected by the application of temporal variations of surface drag due to changes in sea state provided the choice of a suitable constant Charnock parameter in the sea-state-independent case. Including essential meteorological features on smaller scales and minimising interpolation errors by increasing forcing data resolution are shown to be more important for the improvement of model performance particularly at the high tail of the probability distribution. This is found in a modelling study using WAQUA/DCSMv5 by evaluating the influence of a realistic air-sea momentum transfer parameterization and comparing it to the influence of changes in the spatial and temporal resolution of the applied forcing fields in an effort to support the improvement of impact and climate analysis studies. Particular attention is given to the representation of extreme water levels over the past decades based on the example of the Netherlands. For this, WAQUA/DCSMv5 is forced with ERA-Interim reanalysis data. Model results are obtained from a set of different forcing fields, which either (i) include a wave-state-dependent Charnock parameter or (ii) apply a constant Charnock parameter ( α C h = 0.032) tuned for young sea states in the North Sea, but differ in their spatial and/or temporal resolution. Increasing forcing field resolution from roughly 79 to 12 km through dynamically downscaling can reduce the modelled low bias, depending on coastal station, by up to 0.25 m for the modelled extreme water levels with a 1-year return period and between 0.1 m and 0.5 m for extreme surge heights.

Growth and stable isotope signals associated with drought-related mortality in saplings of two coexisting pine species.

PubMed

Herrero, Asier; Castro, Jorge; Zamora, Regino; Delgado-Huertas, Antonio; Querejeta, José I

2013-12-01

Drought-induced events of massive tree mortality appear to be increasing worldwide. Species-specific vulnerability to drought mortality may alter patterns of species diversity and affect future forest composition. We have explored the consequences of the extreme drought of 2005, which caused high sapling mortality (approx. 50 %) among 10-year-old saplings of two coexisting pine species in the Mediterranean mountains of Sierra Nevada (Spain): boreo-alpine Pinus sylvestris and Mediterranean P. nigra. Sapling height growth, leaf δ(13)C and δ(18)O, and foliar nitrogen concentration in the four most recent leaf cohorts were measured in dead and surviving saplings. The foliar isotopic composition of dead saplings (which reflects time-integrated leaf gas-exchange until mortality) displayed sharp increases in both δ(13)C and δ(18)O during the extreme drought of 2005, suggesting an important role of stomatal conductance (g(s)) reduction and diffusional limitations to photosynthesis in mortality. While P. nigra showed decreased growth in 2005 compared to the previous wetter year, P. sylvestris maintained similar growth levels in both years. Decreased growth, coupled with a sharper increase in foliar δ(18)O during extreme drought in dead saplings, indicate a more conservative water use strategy for P. nigra. The different physiological behavior of the two pine species in response to drought (further supported by data from surviving saplings) may have influenced 2005 mortality rates, which contributed to 2.4-fold greater survival for P. nigra over the lifespan of the saplings. This species-specific vulnerability to extreme drought could lead to changes in dominance and distribution of pine species in Mediterranean mountain forests.

Evolution of the core and pan-genome of Streptococcus: positive selection, recombination, and genome composition

PubMed Central

Lefébure, Tristan; Stanhope, Michael J

2007-01-01

Background The genus Streptococcus is one of the most diverse and important human and agricultural pathogens. This study employs comparative evolutionary analyses of 26 Streptococcus genomes to yield an improved understanding of the relative roles of recombination and positive selection in pathogen adaptation to their hosts. Results Streptococcus genomes exhibit extreme levels of evolutionary plasticity, with high levels of gene gain and loss during species and strain evolution. S. agalactiae has a large pan-genome, with little recombination in its core-genome, while S. pyogenes has a smaller pan-genome and much more recombination of its core-genome, perhaps reflecting the greater habitat, and gene pool, diversity for S. agalactiae compared to S. pyogenes. Core-genome recombination was evident in all lineages (18% to 37% of the core-genome judged to be recombinant), while positive selection was mainly observed during species differentiation (from 11% to 34% of the core-genome). Positive selection pressure was unevenly distributed across lineages and biochemical main role categories. S. suis was the lineage with the greatest level of positive selection pressure, the largest number of unique loci selected, and the largest amount of gene gain and loss. Conclusion Recombination is an important evolutionary force in shaping Streptococcus genomes, not only in the acquisition of significant portions of the genome as lineage specific loci, but also in facilitating rapid evolution of the core-genome. Positive selection, although undoubtedly a slower process, has nonetheless played an important role in adaptation of the core-genome of different Streptococcus species to different hosts. PMID:17475002

Seasonal temperature acclimatization in a semi-fossorial mammal and the role of burrows as thermal refuges

PubMed Central

Rachlow, Janet L.; Chappell, Mark A.; Camp, Meghan J.; Johnson, Timothy R.; Shipley, Lisa A.; Paul, David R.; Forbey, Jennifer S.

2018-01-01

Small mammals in habitats with strong seasonal variation in the thermal environment often exhibit physiological and behavioral adaptations for coping with thermal extremes and reducing thermoregulatory costs. Burrows are especially important for providing thermal refuge when above-ground temperatures require high regulatory costs (e.g., water or energy) or exceed the physiological tolerances of an organism. Our objective was to explore the role of burrows as thermal refuges for a small endotherm, the pygmy rabbit (Brachylagus idahoensis), during the summer and winter by quantifying energetic costs associated with resting above and below ground. We used indirect calorimetry to determine the relationship between energy expenditure and ambient temperature over a range of temperatures that pygmy rabbits experience in their natural habitat. We also measured the temperature of above- and below-ground rest sites used by pygmy rabbits in eastern Idaho, USA, during summer and winter and estimated the seasonal thermoregulatory costs of resting in the two microsites. Although pygmy rabbits demonstrated seasonal physiological acclimatization, the burrow was an important thermal refuge, especially in winter. Thermoregulatory costs were lower inside the burrow than in above-ground rest sites for more than 50% of the winter season. In contrast, thermal heterogeneity provided by above-ground rest sites during summer reduced the role of burrows as a thermal refuge during all but the hottest periods of the afternoon. Our findings contribute to an understanding of the ecology of small mammals in seasonal environments and demonstrate the importance of burrows as thermal refuge for pygmy rabbits. PMID:29576977

Integrating new indicators of predictors that shape the public's perception of local extreme temperature in China.

PubMed

Ban, Jie; Huang, Lei; Chen, Chen; Guo, Yuming; He, Mike Z; Li, Tiantian

2017-02-01

The public's risk perception of local extreme heat or cold plays a critical role in community health and prevention under climate change. However, there is limited evidence on such issues in China where extreme weather is occurring more frequently due to climate change. Here, a total of 2500 residents were selected using a three-step sampling method and investigated by a questionnaire in two representative cities. We investigated risk perception of extreme heat in Beijing and extreme cold in Harbin in 2013, aiming to examine their possible correlations with multiple epidemiological factors. We found that exposure, vulnerability, and adaptive ability were significant predictors in shaping public risk perceptions of local extreme temperature. In particular, a 1°C increase in daily temperature resulted in an increased odds of perceiving serious extreme heat in Beijing (OR=1.091; 95% CI: 1.032, 1.153), while a 1°C increase in daily temperature resulted in a decreased odds of perceiving serious extreme cold in Harbin (OR=0.965; 95% CI: 0.939, 0.992). Therefore for both extreme heat and cold, frequent local extreme temperature exposure may amplify a stronger communication. Health interventions for extreme temperature should consider exposure, vulnerability, and adaptive ability factors. This will help improve the public's perception of climatic changes and their willingness to balance adaption and mitigation appropriately. Copyright © 2016 Elsevier B.V. All rights reserved.

Precipitation trends in the Canary Islands

NASA Astrophysics Data System (ADS)

García-Herrera, Ricardo; Gallego, David; Hernández, Emiliano; Gimeno, Luis; Ribera, Pedro; Calvo, Natalia

2003-02-01

A strong decreasing trend in the Canary Islands' precipitation is detected by studying daily rainfall time series for the second half of the 20th century. An analysis of the extreme events shows that this trend is due mainly to a decrease in the upper percentiles of the precipitation distribution. The results suggest that local factors play a fundamental role on extreme event behaviour.

Structure, Function and Floristic Relationships of Plant Communities in Stressful Habitats Marginal to the Brazilian Atlantic Rainforest

PubMed Central

SCARANO, FABIO R.

2002-01-01

The Brazilian Atlantic rainforest consists of a typical tropical rainforest on mountain slopes, and stands out as a biodiversity hotspot for its high species richness and high level of species endemism. This forest is bordered by plant communities with lower species diversity, due mostly to more extreme environmental conditions than those found in the mesic rainforest. Between the mountain slopes and the sea, the coastal plains have swamp forests, dry semi‐deciduous forests and open thicket vegetation on marine sand deposits. At the other extreme, on top of the mountains (>2000 m a.s.l.), the rainforest is substituted by high altitude fields and open thicket vegetation on rocky outcrops. Thus, the plant communities that are marginal to the rainforest are subjected either to flooding, drought, oceanicity or cold winter temperatures. It was found that positive interactions among plants play an important role in the structuring and functioning of a swamp forest, a coastal sandy vegetation and a cold, high altitude vegetation in the state of Rio de Janeiro. Moreover, only a few species seem to adopt this positive role and, therefore, the functioning of these entire systems may rely on them. Curiously, these nurse plants are often epiphytes in the rainforest, and at the study sites are typically terrestrial. Many exhibit crassulacean acid metabolism. Conservation initiatives must treat the Atlantic coastal vegetation as a complex rather than a rainforest alone. PMID:12324276

Descriptive analysis of kinematics and kinetics of catchers throwing to second base from their knees.

PubMed

Plummer, Hillary A; Oliver, Gretchen D

2016-08-01

In order to decrease the amount of time that it takes the catcher to throw the ball, a catcher may chose to throw from the knees. Upper extremity kinematics may play a significant role in the kinetics about the elbow observed in catchers throwing from the knees. If relationships between kinematics and kinetics exist then the development of training and coaching instruction may help in reduced upper extremity injury risk. Twenty-two baseball and softball catchers (14.36±3.86years; 165.11±17.54cm; 65.67±20.60kg) volunteered. The catchers exhibited a less trunk rotation (5.6±16.2°), greater elbow flexion (87.9±21.4°) and decreased humeral elevation (71.1±12.3°) at the event of maximum shoulder external rotation as compared to what has previously reported in catchers. These variables are important, as they have previously been established as potential injury risk factors in pitchers, however it is not yet clear the role these variables play in catchers' risk of injury. A positive relationship between elbow varus torque during the deceleration phase and elbow flexion at MIR was observed (r=0.609; p=0.003). Throwing from the knees reduces a catcher's ability to utilize the proximal kinetic chain and this may help to explain why their kinematics and kinetics differ from what has previously been presented in the literature. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Essential Role of the Deinococcus radiodurans ssb Gene in Cell Survival and Radiation Tolerance

PubMed Central

Lockhart, J. Scott; DeVeaux, Linda C.

2013-01-01

Recent evidence has implicated single-stranded DNA-binding protein (SSB) expression level as an important factor in microbial radiation resistance. The genome of the extremely radiation resistant bacterium Deinococcus radiodurans contains genes for two SSB homologs: the homodimeric, canonical Ssb, encoded by the gene ssb, and a novel pentameric protein encoded by the gene ddrB. ddrB is highly induced upon exposure to radiation, and deletions result in decreased radiation-resistance, suggesting an integral role of the protein in the extreme resistance exhibited by this organism. Although expression of ssb is also induced after irradiation, Ssb is thought to be involved primarily in replication. In this study, we demonstrate that Ssb in D. radiodurans is essential for cell survival. The lethality of an ssb deletion cannot be complemented by providing ddrB in trans. In addition, the radiation-sensitive phenotype conferred by a ddrB deletion is not alleviated by providing ssb in trans. By altering expression of the ssb gene, we also show that lower levels of transcription are required for optimal growth than are necessary for high radiation resistance. When expression is reduced to that of E. coli, ionizing radiation resistance is similarly reduced. UV resistance is also decreased under low ssb transcript levels where growth is unimpaired. These results indicate that the expression of ssb is a key component of both normal cellular metabolism as well as pathways responsible for the high radiation tolerance of D. radiodurans. PMID:23951213

Evaluation of Potential Climate Change Impacts on Particle Movement in Open Channel Flow

NASA Astrophysics Data System (ADS)

Lin, E.; Tsai, C.

2014-12-01

It is important to develop a forecast model to predict the trajectory of sediment particles when extreme flow events occur. In extreme flow environments, the stochastic jump diffusion particle tracking model (SJD-PTM) can be used to model the movement of sediment particles in response to extreme events. This proposed SJD-PTM can be separated into three main parts — a drift motion, a turbulence term and a jump term due to random occurrences of extreme flow events. The study is intended to modify the jump term, which models the abrupt changes of particle position in the extreme flow environments. The frequency of extreme flow occurrences might change due to many uncertain factors such as climate change. The study attempts to use the concept of the logistic regression and the parameter of odds ratio, namely the trend magnitude to investigate the frequency change of extreme flow event occurrences and its impact on sediment particle movement. With the SJD-PTM, the ensemble mean and variance of particle trajectory can be quantified via simulations. The results show that by taking the effect of the trend magnitude into consideration, the particle position and its uncertainty may undergo a significant increase. Such findings will have many important implications to the environmental and hydraulic engineering design and planning. For instance, when the frequency of the occurrence of flow events with higher extremity increases, particles can travel further and faster downstream. It is observed that flow events with higher extremity can induce a higher degree of entrainment and particle resuspension, and consequently more significant bed and bank erosion.

Soil Bacterial and Fungal Communities Show Distinct Recovery Patterns during Forest Ecosystem Restoration

PubMed Central

Li, Song; Avera, Bethany N.; Strahm, Brian D.; Badgley, Brian D.

2017-01-01

ABSTRACT Bacteria and fungi are important mediators of biogeochemical processes and play essential roles in the establishment of plant communities, which makes knowledge about their recovery after extreme disturbances valuable for understanding ecosystem development. However, broad ecological differences between bacterial and fungal organisms, such as growth rates, stress tolerance, and substrate utilization, suggest they could follow distinct trajectories and show contrasting dynamics during recovery. In this study, we analyzed both the intra-annual variability and decade-scale recovery of bacterial and fungal communities in a chronosequence of reclaimed mined soils using next-generation sequencing to quantify their abundance, richness, β-diversity, taxonomic composition, and cooccurrence network properties. Bacterial communities shifted gradually, with overlapping β-diversity patterns across chronosequence ages, while shifts in fungal communities were more distinct among different ages. In addition, the magnitude of intra-annual variability in bacterial β-diversity was comparable to the changes across decades of chronosequence age, while fungal communities changed minimally across months. Finally, the complexity of bacterial cooccurrence networks increased with chronosequence age, while fungal networks did not show clear age-related trends. We hypothesize that these contrasting dynamics of bacteria and fungi in the chronosequence result from (i) higher growth rates for bacteria, leading to higher intra-annual variability; (ii) higher tolerance to environmental changes for fungi; and (iii) stronger influence of vegetation on fungal communities. IMPORTANCE Both bacteria and fungi play essential roles in ecosystem functions, and information about their recovery after extreme disturbances is important for understanding whole-ecosystem development. Given their many differences in phenotype, phylogeny, and life history, a comparison of different bacterial and fungal recovery patterns improves the understanding of how different components of the soil microbiota respond to ecosystem recovery. In this study, we highlight key differences between soil bacteria and fungi during the restoration of reclaimed mine soils in the form of long-term diversity patterns, intra-annual variability, and potential interaction networks. Cooccurrence networks revealed increasingly complex bacterial community interactions during recovery, in contrast to much simpler and more isolated fungal network patterns. This study compares bacterial and fungal cooccurrence networks and reveals cooccurrences persisting through successional ages. PMID:28476769

Soil Bacterial and Fungal Communities Show Distinct Recovery Patterns during Forest Ecosystem Restoration.

PubMed

Sun, Shan; Li, Song; Avera, Bethany N; Strahm, Brian D; Badgley, Brian D

2017-07-15

Bacteria and fungi are important mediators of biogeochemical processes and play essential roles in the establishment of plant communities, which makes knowledge about their recovery after extreme disturbances valuable for understanding ecosystem development. However, broad ecological differences between bacterial and fungal organisms, such as growth rates, stress tolerance, and substrate utilization, suggest they could follow distinct trajectories and show contrasting dynamics during recovery. In this study, we analyzed both the intra-annual variability and decade-scale recovery of bacterial and fungal communities in a chronosequence of reclaimed mined soils using next-generation sequencing to quantify their abundance, richness, β-diversity, taxonomic composition, and cooccurrence network properties. Bacterial communities shifted gradually, with overlapping β-diversity patterns across chronosequence ages, while shifts in fungal communities were more distinct among different ages. In addition, the magnitude of intra-annual variability in bacterial β-diversity was comparable to the changes across decades of chronosequence age, while fungal communities changed minimally across months. Finally, the complexity of bacterial cooccurrence networks increased with chronosequence age, while fungal networks did not show clear age-related trends. We hypothesize that these contrasting dynamics of bacteria and fungi in the chronosequence result from (i) higher growth rates for bacteria, leading to higher intra-annual variability; (ii) higher tolerance to environmental changes for fungi; and (iii) stronger influence of vegetation on fungal communities. IMPORTANCE Both bacteria and fungi play essential roles in ecosystem functions, and information about their recovery after extreme disturbances is important for understanding whole-ecosystem development. Given their many differences in phenotype, phylogeny, and life history, a comparison of different bacterial and fungal recovery patterns improves the understanding of how different components of the soil microbiota respond to ecosystem recovery. In this study, we highlight key differences between soil bacteria and fungi during the restoration of reclaimed mine soils in the form of long-term diversity patterns, intra-annual variability, and potential interaction networks. Cooccurrence networks revealed increasingly complex bacterial community interactions during recovery, in contrast to much simpler and more isolated fungal network patterns. This study compares bacterial and fungal cooccurrence networks and reveals cooccurrences persisting through successional ages. Copyright © 2017 American Society for Microbiology.

Weak linkage between the heaviest rainfall and tallest storms.

PubMed

Hamada, Atsushi; Takayabu, Yukari N; Liu, Chuntao; Zipser, Edward J

2015-02-24

Conventionally, the heaviest rainfall has been linked to the tallest, most intense convective storms. However, the global picture of the linkage between extreme rainfall and convection remains unclear. Here we analyse an 11-year record of spaceborne precipitation radar observations and establish that a relatively small fraction of extreme convective events produces extreme rainfall rates in any region of the tropics and subtropics. Robust differences between extreme rainfall and convective events are found in the rainfall characteristics and environmental conditions, irrespective of region; most extreme rainfall events are characterized by less intense convection with intense radar echoes not extending to extremely high altitudes. Rainfall characteristics and environmental conditions both indicate the importance of warm-rain processes in producing extreme rainfall rates. Our results demonstrate that, even in regions where severe convective storms are representative extreme weather events, the heaviest rainfall events are mostly associated with less intense convection.

Functional analysis of the Glucan Degradation Locus (GDL) in Caldicellulosiruptor bescii reveals essential roles of component glycoside hydrolases in plant biomass deconstruction.

PubMed

Conway, Jonathan M; McKinley, Bennett S; Seals, Nathaniel L; Hernandez, Diana; Khatibi, Piyum A; Poudel, Suresh; Giannone, Richard J; Hettich, Robert L; Williams-Rhaesa, Amanda M; Lipscomb, Gina L; Adams, Michael W W; Kelly, Robert M

2017-10-06

The ability to hydrolyze microcrystalline cellulose is an uncommon feature in the microbial world, but one that can be exploited for conversion of lignocellulosic feedstocks into bio-based fuels and chemicals. Understanding the physiological and biochemical mechanisms by which microorganisms deconstruct cellulosic material is key to achieving this objective. The Glucan Degradation Locus (GDL) in the genomes of extremely thermophilic Caldicellulosiruptor species encodes polysaccharide lyases (PLs), unique cellulose binding proteins (tāpirins), and putative post-translational modifying enzymes, in addition to multi-domain, multi-functional glycoside hydrolases (GHs), thereby representing an alternative paradigm for plant biomass degradation, as compared to fungal or cellulosomal systems. To examine the individual and collective in vivo roles of the glycolytic enzymes, the six GHs in the GDL of Caldicellulosiruptor bescii were systematically deleted, and the extent to which the resulting mutant strains could solubilize microcrystalline cellulose (Avicel) and plant biomasses (switchgrass or poplar) was examined. Three of the GDL enzymes, Athe_1867 (CelA) (GH9-CBM3-CBM3-CBM3-GH48), Athe_1859 (GH5-CBM3-CBM3-GH44), and Athe_1857 (GH10-CBM3-CBM3-GH48), acted synergistically in vivo and accounted for 92% of naked microcellulose (Avicel) degradation. However, the relative importance of the GDL GHs varied for the plant biomass substrates tested. Furthermore, mixed cultures of mutant strains showed switchgrass solubilization depended on the secretome-bound enzymes collectively produced by the culture and not on the specific strain from which they came. These results demonstrate that certain GDL GHs are primarily responsible for the degradation of microcrystalline-containing substrates by C. bescii and provide new insights into the workings of a novel microbial mechanism for lignocellulose utilization. Importance The efficient and extensive degradation of complex polysaccharides in lignocellulosic biomass, particularly microcrystalline cellulose, remains a major barrier to its use as a renewable feedstock for the production of fuels and chemicals. Extremely thermophilic bacteria from the genus Caldicellulosiruptor rapidly degrade plant biomass to fermentable sugars at temperatures between 70-78°C, although the specific mechanism by which this occurs is not clear. Previous comparative genomic studies identified a genomic locus found only in certain Caldicellulosiruptor species that was hypothesized to be mainly responsible for microcrystalline cellulose degradation. By systematically deleting genes in this locus in Caldicellulosiruptor bescii , the nuanced, substrate-specific, in vivo roles of glycolytic enzymes in deconstructing crystalline cellulose and plant biomasses could be discerned. The results here point to synergism of three multi-domain cellulases in C. bescii , working in conjunction with the aggregate, secreted enzyme inventory, as the key to the plant biomass degradation ability by this extreme thermophile. Copyright © 2017 American Society for Microbiology.

Functional Analysis of the Glucan Degradation Locus in Caldicellulosiruptor bescii Reveals Essential Roles of Component Glycoside Hydrolases in Plant Biomass Deconstruction

PubMed Central

Conway, Jonathan M.; McKinley, Bennett S.; Seals, Nathaniel L.; Hernandez, Diana; Khatibi, Piyum A.; Poudel, Suresh; Giannone, Richard J.; Hettich, Robert L.; Williams-Rhaesa, Amanda M.; Lipscomb, Gina L.; Adams, Michael W. W.

2017-01-01

ABSTRACT The ability to hydrolyze microcrystalline cellulose is an uncommon feature in the microbial world, but it can be exploited for conversion of lignocellulosic feedstocks into biobased fuels and chemicals. Understanding the physiological and biochemical mechanisms by which microorganisms deconstruct cellulosic material is key to achieving this objective. The glucan degradation locus (GDL) in the genomes of extremely thermophilic Caldicellulosiruptor species encodes polysaccharide lyases (PLs), unique cellulose binding proteins (tāpirins), and putative posttranslational modifying enzymes, in addition to multidomain, multifunctional glycoside hydrolases (GHs), thereby representing an alternative paradigm for plant biomass degradation compared to fungal or cellulosomal systems. To examine the individual and collective in vivo roles of the glycolytic enzymes, the six GH genes in the GDL of Caldicellulosiruptor bescii were systematically deleted, and the extents to which the resulting mutant strains could solubilize microcrystalline cellulose (Avicel) and plant biomass (switchgrass or poplar) were examined. Three of the GDL enzymes, Athe_1867 (CelA) (GH9-CBM3-CBM3-CBM3-GH48), Athe_1859 (GH5-CBM3-CBM3-GH44), and Athe_1857 (GH10-CBM3-CBM3-GH48), acted synergistically in vivo and accounted for 92% of naked microcrystalline cellulose (Avicel) degradation. However, the relative importance of the GDL GHs varied for the plant biomass substrates tested. Furthermore, mixed cultures of mutant strains showed that switchgrass solubilization depended on the secretome-bound enzymes collectively produced by the culture, not on the specific strain from which they came. These results demonstrate that certain GDL GHs are primarily responsible for the degradation of microcrystalline cellulose-containing substrates by C. bescii and provide new insights into the workings of a novel microbial mechanism for lignocellulose utilization. IMPORTANCE The efficient and extensive degradation of complex polysaccharides in lignocellulosic biomass, particularly microcrystalline cellulose, remains a major barrier to its use as a renewable feedstock for the production of fuels and chemicals. Extremely thermophilic bacteria from the genus Caldicellulosiruptor rapidly degrade plant biomass to fermentable sugars at temperatures of 70 to 78°C, although the specific mechanism by which this occurs is not clear. Previous comparative genomic studies identified a genomic locus found only in certain Caldicellulosiruptor species that was hypothesized to be mainly responsible for microcrystalline cellulose degradation. By systematically deleting genes in this locus in Caldicellulosiruptor bescii, the nuanced, substrate-specific in vivo roles of glycolytic enzymes in deconstructing crystalline cellulose and plant biomasses could be discerned. The results here point to synergism of three multidomain cellulases in C. bescii, working in conjunction with the aggregate secreted enzyme inventory, as the key to the plant biomass degradation ability of this extreme thermophile. PMID:28986379

Impact of realistic soil moisture initialization on the representation of extreme events in the western Mediterranean

NASA Astrophysics Data System (ADS)

Helgert, Sebastian; Khodayar, Samiro

2017-04-01

In a warmer Mediterranean climate an increase in the intensity and frequency of extreme events like floods, droughts and extreme heat is expected. The ability to predict such events is still a great challenge and exhibits many uncertainties in the weather forecast and climate predictions. Thereby the missing knowledge about soil moisture-atmosphere interactions and their representation in models is identified as one of the main sources of uncertainty. In this context the soil moisture(SM) plays an important role in the partitioning of sensible and latent heat fluxes on the surface and consequently influences the boundary-layer stability and the precipitation formation. The aim of this research work is to assess the influence of soil moisture-atmosphere interactions on the initiation and development of extreme events in the western Mediterranean (WMED). In this respect the impact of realistic SM initialization on the model representation of extreme events is investigated. High-resolution simulations of different regions in the WMED, including various climate zones from moderate to arid climate, are conducted with the atmospheric COSMO (Consortium for Small-scale Modeling) model in the numerical weather prediction and climate mode. A multiscale temporal and spatial approach is used (days to years, 7km to 2.8km grid spacing). Observational data provided by the framework of the HYdrological cycle in the Mediterranean EXperiment (HyMeX) as well as satellite data such as precipitation from CMORPH (CPC MORPHing technique), evapotranspiration from Land Surface Analysis Satellite Applications Facility (LSA-SAF) and atmospheric moisture from MODIS (Moderate Resolution Imaging Spectroradiometer) are used for process understanding and model validation. To select extreme dry and wet periods the Effective Drought Index (EDI) is calculated. In these periods sensitivity studies of extreme SM initialization scenarios are performed to prove a possible impact of soil moisture on precipitation in the WMED. For the realistic SM initialization different state-of-art high-resolution SM products (25km up to 1km grid spacing) of the Soil Moisture Ocean Salinity mission (SMOS) are examined. A CDF-matching method is applied to reduce the bias between model and SMOS-satellite observation. Moreover, techniques to estimate the initial soil moisture profile from satellite data are tested.

The Extreme Flooding of July 2012 in Krymsk, Russia, from a Climate Perspective

NASA Astrophysics Data System (ADS)

Meredith, Edmund; Semenov, Vladimir; Maraun, Douglas; Park, Wonsun

2014-05-01

One of the most devastating meteorological extremes during recent years has been the extreme precipitation event along Russia's Black Sea coast, near the town of Krymsk, during the 6th and 7th of July 2012. The town was inundated by the ensuing downslope deluge; torrents of water caused widespread destruction and lead to over 170 deaths. The extreme precipitation was caused by a low pressure system that advected warm and moist air north-eastwards from the Black Sea. Whether global warming contributed to the unprecedented magnitude of this event remains unclear. Sea surface temperatures in the Black Sea have exhibited a strong and continuous upward trend over the last decades, with warming exceeding 2K in some regions. As the Black Sea served as the principal moisture source for the observed extreme precipitation, we investigate the impact of the increased SSTs on the properties of the cyclone and the resultant magnitude of the precipitation. This is done by employing ensemble sensitivity simulations with the WRF regional model, in both nudged and unnudged mode. The model is run for an eastern Black Sea domain using multiply nested sub-domains increasing up to very high, convection resolving, resolution to simulate the observed event. The model's ability to reproduce the extreme event is first verified. The simulations are then repeated with reduced SST, characteristic of the last decades of the 20th century. Our results suggest that such an extreme event would not have been possible without the current warmed SSTs. We find that the increased SSTs played an important role in amplifying the precipitation experienced near Krymsk, facilitating enhanced moisture fluxes and increasing instability within the planetary boundary layer (PBL). While the location of the heaviest precipitation remains broadly similar, the magnitude of the simulated precipitation caused by the same cyclone passing over the cooler SSTs was reduced, on average, by a factor of three or more in most places. Likewise, surface evaporation from the Black Sea is decreased by a factor of three to four over much of the eastern Black Sea, giving reduced moisture advection towards the coastal hills surrounding Krymsk. An analogous decrease in surface latent heat fluxes adds stability to the PBL through reduced moisture and heat, the latter indicated by a more than twofold decrease in PBL heights.

Controlling extreme events on complex networks

NASA Astrophysics Data System (ADS)

Chen, Yu-Zhong; Huang, Zi-Gang; Lai, Ying-Cheng

2014-08-01

Extreme events, a type of collective behavior in complex networked dynamical systems, often can have catastrophic consequences. To develop effective strategies to control extreme events is of fundamental importance and practical interest. Utilizing transportation dynamics on complex networks as a prototypical setting, we find that making the network ``mobile'' can effectively suppress extreme events. A striking, resonance-like phenomenon is uncovered, where an optimal degree of mobility exists for which the probability of extreme events is minimized. We derive an analytic theory to understand the mechanism of control at a detailed and quantitative level, and validate the theory numerically. Implications of our finding to current areas such as cybersecurity are discussed.

The Importance of Visit Notes on Patient Portals for Engaging Less Educated or Nonwhite Patients: Survey Study

PubMed Central

Gerard, Macda; Chimowitz, Hannah; Fossa, Alan; Bourgeois, Fabienne; Fernandez, Leonor

2018-01-01

Background OpenNotes, a national initiative to share clinicians’ visit notes with patients, can improve patient engagement, but effects on vulnerable populations are not known very well. Objective Our aim is to examine the importance of visit notes to nonwhite and less educated patients. Methods Patients at an urban academic medical center with an active patient portal account and ≥1 available ambulatory visit note over the prior year were surveyed during June 2016 until September 2016. The survey was designed with patients and families and assessed importance of reading notes (scale 0-10) for (1) understanding health conditions, (2) feeling informed about care, (3) understanding the provider’s thought process, (4) remembering the plan of care, and (5) making decisions about care. We compared the proportion of patients reporting 9-10 (extremely important) for each item stratified by education level, race/ethnicity, and self-reported health. Principal component analysis and correlation measures supported a summary score for the 5 items (Cronbach alpha=.93). We examined factors associated with rating notes as extremely important to engage in care using logistic regression. Results Of 24,722 patients, 6913 (27.96%) completed the survey. The majority (6736/6913, 97.44%) read at least one note. Among note readers, 74.0% (727/982) of patients with ≤high school education, 70.7% (130/184) of black patients, and 69.9% (153/219) of Hispanic/Latino patients reported that notes are extremely important to feel informed about their care. The majority of less educated and nonwhite patients reported notes as extremely important to remember the care plan (62.4%, 613/982 ≤high school education; 62.0%, 114/184 black patients; and 61.6%, 135/219 Hispanic/Latino patients) and to make care decisions (62.3%, 612/982; 59.8%, 110/184; and 58.5%, 128/219, respectively, and P<.003 for all comparisons to more educated and white patients, respectively). Among patients with the poorest self-reported health, 65.9% (499/757) found notes extremely important to be informed and to understand the provider. On multivariable modeling, less educated patients were nearly three times as likely to report notes were extremely important to engage in care compared with the most educated patients (odds ratio [OR] 2.9, 95% CI 2.4-3.3). Nonwhite patients were twice as likely to report the same compared with white patients (OR 2.0, 95% CI 1.5-2.7 [black] and OR 2.2, 95% CI 1.6-2.9 [Hispanic/Latino and Asian], P<.001 for each comparison). Healthier patients, women, older patients, and those who read more notes were more likely to find notes extremely important to engage in care. Conclusions Less educated and nonwhite patients using the portal each assigned higher importance to reading notes for several health behaviors than highly educated and white patients, and may find transparent notes especially valuable for understanding their health and engaging in their care. Facilitating access to notes may improve engagement in health care for some vulnerable populations who have historically been more challenging to reach. PMID:29793900

The world at 1.5°C: Understanding its regional dimensions and driving processes

NASA Astrophysics Data System (ADS)

Seneviratne, S. I.; Wartenburger, R.; Vogel, M.; Hirsch, A.; Guillod, B.; Donat, M.; Pitman, A. J.; Davin, E.; Greve, P.; Hirschi, M.

2017-12-01

This presentation reviews the available evidence regarding projected regional changes in climate extremes at 1.5°C vs higher levels of warming based on recent analyses (Seneviratne et al. 2016; Wartenburger et al., submitted; Greve et al., submitted). In several regions, significant differences in the occurrence of climate extremes can be identified already for half a degree of warming when assessing changes at 1.5°C vs 2°C global warming. An important feature is the much stronger warming of hot extremes in several continental regions compared to the global mean warming, which implies that temperature extremes can warm regionally by much more than 1.5°C, even if global temperature warming is stabilized at this level (e.g. up to 6°C for certain models in the Arctic). This feature is due to a combination of feedbacks and internal climate variability. We highlight in particular the importance of land-climate feedbacks for projected changes in hot extremes in mid-latitude regions (Vogel et al. 2017). Because of the strong effects of land processes on regional changes in temperature extremes, changes in land surface properties, including land use changes, are found to be particularly important for projections in low-emissions scenarios (Hirsch et al. 2017; Guillod et al., submitted). References: Greve, P., et al.: Regional scaling of annual mean precipitation and water availability with global temperature change. Submitted. Guillod, B.P., et al.: Land use in low climate warming targets critical for hot extreme projections. Submitted. Hirsch, A.L., et al., 2017: Can climate-effective land management reduce regional warming? J. Geophys. Res. Atmos., 122, 2269-2288, doi:10.1002/2016JD026125. Seneviratne, S.I., et al., 2016: Allowable CO2 emissions based on regional and impact-related climate targets. Nature, 529, 477-483, doi:10.1038/nature16542. Vogel, M.M., et al., 2017: Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks. Geophysical Research Letters, 44(3), 1511-1519. Wartenburger, R., et al.: Changes in regional climate extremes as a function of global mean temperature: an interactive plotting framework. Geosci. Model Dev. - Submitt.,

Changing roles of propagule, climate, and land use during extralimital colonization of a rose chafer beetle

NASA Astrophysics Data System (ADS)

Horak, Jakub; Hui, Cang; Roura-Pascual, Núria; Romportl, Dusan

2013-04-01

Regardless of their ecosystem functions, some insects are threatened when facing environmental changes and disturbances, while others become extremely successful. It is crucial for successful conservation to differentiate factors supporting species' current distributions from those triggering range dynamics. Here, we studied the sudden extralimital colonization of the rose chafer beetle, Oxythyrea funesta, in the Czech Republic. Specifically, we depicted the range expansion using accumulated historical records of first known occurrences and then explained the colonization events using five transformed indices depicting changes in local propagule pressure (LPP), climate, land use, elevation, and landscape structure. The slow occupancy increase of O. funesta before 1990 changed to a phase of rapid occupancy increase after 1990, driven not only by changes in the environment (climate and land use) but also by the spatial accumulation of LPP. Climate was also found to play a significant role but only during the niche-filling stage before 1990, while land use became important during the phase of rapid expansion after 1990. Inland waters (e.g., riparian corridors) also contributed substantially to the spread in the Czech Republic. Our method of using spatially transformed variables to explain the colonization events provides a novel way of detecting factors triggering range dynamics. The results highlight the importance of LPP in driving sudden occupancy increase of extralimital species and recommend the use of LPP as an important predictor for modeling range dynamics.

Extreme weather caused by concurrent cyclone, front and thunderstorm occurrences

PubMed Central

Dowdy, Andrew J.; Catto, Jennifer L.

2017-01-01

Phenomena such as cyclones, fronts and thunderstorms can cause extreme weather in various regions throughout the world. Although these phenomena have been examined in numerous studies, they have not all been systematically examined in combination with each other, including in relation to extreme precipitation and extreme winds throughout the world. Consequently, the combined influence of these phenomena represents a substantial gap in the current understanding of the causes of extreme weather events. Here we present a systematic analysis of cyclones, fronts and thunderstorms in combination with each other, as represented by seven different types of storm combinations. Our results highlight the storm combinations that most frequently cause extreme weather in various regions of the world. The highest risk of extreme precipitation and extreme wind speeds is found to be associated with a triple storm type characterized by concurrent cyclone, front and thunderstorm occurrences. Our findings reveal new insight on the relationships between cyclones, fronts and thunderstorms and clearly demonstrate the importance of concurrent phenomena in causing extreme weather. PMID:28074909

Large-scale drivers of local precipitation extremes in convection-permitting climate simulations

NASA Astrophysics Data System (ADS)

Chan, Steven C.; Kendon, Elizabeth J.; Roberts, Nigel M.; Fowler, Hayley J.; Blenkinsop, Stephen

2016-04-01

The Met Office 1.5-km UKV convective-permitting models (CPM) is used to downscale present-climate and RCP8.5 60-km HadGEM3 GCM simulations. Extreme UK hourly precipitation intensities increase with local near-surface temperatures and humidity; for temperature, the simulated increase rate for the present-climate simulation is about 6.5% K**-1, which is consistent with observations and theoretical expectations. While extreme intensities are higher in the RCP8.5 simulation as higher temperatures are sampled, there is a decline at the highest temperatures due to circulation and relative humidity changes. Extending the analysis to the broader synoptic scale, it is found that circulation patterns, as diagnosed by MSLP or circulation type, play an increased role in the probability of extreme precipitation in the RCP8.5 simulation. Nevertheless for both CPM simulations, vertical instability is the principal driver for extreme precipitation.

Multimodality management of soft tissue tumors in the extremity

PubMed Central

Crago, Aimee M.; Lee, Ann Y.

2016-01-01

Most extremity soft tissue sarcomas present as a painless mass. Workup should generally involve cross-sectional imaging with MRI, as well as a core biopsy for pathologic diagnosis. Limb-sparing surgery is the standard of care, and may be supplemented with radiation for histologic subtypes at higher risk for local recurrence and chemotherapy for those at higher risk for distant metastases. This article reviews the work-up and surgical approach to extremity soft tissue sarcomas, as well as the role for radiation and chemotherapy, with particular attention given to the distinguishing characteristics of some of the most common subtypes. PMID:27542637

Early neurodevelopmental outcomes of extremely preterm infants.

PubMed

Rogers, Elizabeth E; Hintz, Susan R

2016-12-01

Infants born at extreme preterm gestation are at risk for both death and disability. Although rates of survival have improved for this population, and some evidence suggests a trend toward decreased neuromotor impairment over the past decades, a significant improvement in overall early neurodevelopmental outcome has not yet been realized. This review will examine the rates and types of neurodevelopmental impairment seen after extremely preterm birth, including neurosensory, motor, cognitive, and behavioral outcomes. We focus on early outcomes in the first 18-36 months of life, as the majority of large neonatal studies examining neurodevelopmental outcomes stop at this age. However, this early age is clearly just a first glimpse into lifetime outcomes; the neurodevelopmental effects of extreme prematurity may last through school age, adolescence, and beyond. Importantly, prematurity appears to be an independent risk factor for adverse development, but this population demonstrates considerable variability in the types and severity of impairments. Understanding both the nature and prevalence of neurodevelopmental impairment among extremely preterm infants is important because it can lead to targeted interventions that in turn may lead to improved outcomes. Copyright © 2016 Elsevier Inc. All rights reserved.

Tales from the Paleoclimate Underground: Lessons Learned from Reconstructing Extreme Events

NASA Astrophysics Data System (ADS)

Frappier, A. E.

2017-12-01

Tracing patterns of paleoclimate extremes over the past two millennia is becoming ever more important in the effort to understand and predict costly weather hazards and their varied societal impacts. I present three paleoclimate vignettes from the past ten years of different paleotempestology projects I have worked on closely, illustrating our collective challenges and productive pathways in reconstructing rainfall extremes: temporal, spatial, and combining information from disparate proxies. Finally, I aim to share new results from modeling multiple extremes and hazards in Yucatan, a climate change hotspot.

Use of Evidence-Based Practice Among Athletic Training Educators, Clinicians, and Students, Part 1: Perceived Importance, Knowledge, and Confidence

PubMed Central

Hankemeier, Dorice A.; Walter, Jessica M.; McCarty, Cailee W.; Newton, Eric J.; Walker, Stacy E.; Pribesh, Shana L.; Jamali, Beth E.; Manspeaker, Sarah A.; Van Lunen, Bonnie L.

2013-01-01

Context: Although evidence-based practice (EBP) has become more prevalent, athletic trainers' perceptions of importance and knowledge of these concepts and their confidence in EBP are largely unknown. Objective: To assess perceived importance and knowledge of and confidence in EBP concepts in athletic trainers in various roles and with different degree levels. Design: Cross-sectional study. Setting: Online survey instrument. Patients or Other Participants: The survey was sent to 6702 athletic training educators, clinicians, and postprofessional students. A total of 1209 completed the survey, for a response rate of 18.04%. Main Outcome Measure(s): Demographic information and perceived importance and knowledge of and confidence in the steps of EBP were obtained. One-way analysis of variance, a Kruskal-Wallis test, and an independent-samples t test were used to determine differences in scores among the demographic variables. Results: Athletic trainers demonstrated low knowledge scores (64.2% ± 1.29%) and mild to moderate confidence (2.71 ± 0.55 out of 4.0). They valued EBP as moderately to extremely important (3.49 ± 0.41 out of 4.0). Perceived importance scores differed among roles (clinicians unaffiliated with an education program scored lower than postprofessional educators, P = .001) and highest educational degree attained (athletic trainers with terminal degrees scored higher than those with bachelor's or master's degrees, P < .001). Postprofessional athletic training students demonstrated the highest total EBP knowledge scores (4.65 ± 0.91), whereas clinicians demonstrated the lowest scores (3.62 ± 1.35). Individuals with terminal degrees had higher (P < .001) total knowledge scores (4.31 ± 1.24) than those with bachelor's (3.78 ± 1.2) or master's degrees (3.76 ± 1.35). Postprofessional educators demonstrated greater confidence in knowledge scores (3.36 ± 0.40 out of 4.0) than did those in all other athletic training roles (P < .001). Conclusions: Overall knowledge of the basic EBP steps remained low across the various athletic trainers' roles. The higher level of importance indicated that athletic trainers valued EBP, but this value was not reflected in the knowledge of EBP concepts. Individuals with a terminal degree possessed higher knowledge scores than those with other educational preparations; however, EBP knowledge needs to increase across all demographics of the profession. PMID:23675799

What Role for Law, Human Rights, and Bioethics in an Age of Big Data, Consortia Science, and Consortia Ethics? The Importance of Trustworthiness.

PubMed

Dove, Edward S; Özdemir, Vural

2015-09-01

The global bioeconomy is generating new paradigm-shifting practices of knowledge co-production, such as collective innovation; large-scale, data-driven global consortia science (Big Science); and consortia ethics (Big Ethics). These bioeconomic and sociotechnical practices can be forces for progressive social change, but they can also raise predicaments at the interface of law, human rights, and bioethics. In this article, we examine one such double-edged practice: the growing, multivariate exploitation of Big Data in the health sector, particularly by the private sector. Commercial exploitation of health data for knowledge-based products is a key aspect of the bioeconomy and is also a topic of concern among publics around the world. It is exacerbated in the current age of globally interconnected consortia science and consortia ethics, which is characterized by accumulating epistemic proximity, diminished academic independence, "extreme centrism", and conflicted/competing interests among innovation actors. Extreme centrism is of particular importance as a new ideology emerging from consortia science and consortia ethics; this relates to invariably taking a middle-of-the-road populist stance, even in the event of human rights breaches, so as to sustain the populist support needed for consortia building and collective innovation. What role do law, human rights, and bioethics-separate and together-have to play in addressing these predicaments and opportunities in early 21st century science and society? One answer we propose is an intertwined ethico-legal normative construct, namely trustworthiness . By considering trustworthiness as a central pillar at the intersection of law, human rights, and bioethics, we enable others to trust us, which in turns allows different actors (both nonprofit and for-profit) to operate more justly in consortia science and ethics, as well as to access and responsibly use health data for public benefit.

What Role for Law, Human Rights, and Bioethics in an Age of Big Data, Consortia Science, and Consortia Ethics? The Importance of Trustworthiness

PubMed Central

Dove, Edward S.; Özdemir, Vural

2015-01-01

The global bioeconomy is generating new paradigm-shifting practices of knowledge co-production, such as collective innovation; large-scale, data-driven global consortia science (Big Science); and consortia ethics (Big Ethics). These bioeconomic and sociotechnical practices can be forces for progressive social change, but they can also raise predicaments at the interface of law, human rights, and bioethics. In this article, we examine one such double-edged practice: the growing, multivariate exploitation of Big Data in the health sector, particularly by the private sector. Commercial exploitation of health data for knowledge-based products is a key aspect of the bioeconomy and is also a topic of concern among publics around the world. It is exacerbated in the current age of globally interconnected consortia science and consortia ethics, which is characterized by accumulating epistemic proximity, diminished academic independence, “extreme centrism”, and conflicted/competing interests among innovation actors. Extreme centrism is of particular importance as a new ideology emerging from consortia science and consortia ethics; this relates to invariably taking a middle-of-the-road populist stance, even in the event of human rights breaches, so as to sustain the populist support needed for consortia building and collective innovation. What role do law, human rights, and bioethics—separate and together—have to play in addressing these predicaments and opportunities in early 21st century science and society? One answer we propose is an intertwined ethico-legal normative construct, namely trustworthiness. By considering trustworthiness as a central pillar at the intersection of law, human rights, and bioethics, we enable others to trust us, which in turns allows different actors (both nonprofit and for-profit) to operate more justly in consortia science and ethics, as well as to access and responsibly use health data for public benefit. PMID:26345196

Role of adrenals in the mobilization of carbohydrate and fat resources after overstimulation of rats

NASA Technical Reports Server (NTRS)

Khechninashvili, G. G.

1980-01-01

The role of the cortical and cerebral layers of the adrenal glands in mobilizing carbohydrate and fatty resources in response to the effect of an extreme stimulant was investigated. It is shown that following adrenodemedullation and adrenalectomy, the leading role is played by the secretion of the adrenal medullary layer, whereas the role of suprarenals in the mobilization of fats is only slightly pronounced.

Possible future changes in extreme events over Northern Eurasia

NASA Astrophysics Data System (ADS)

Monier, Erwan; Sokolov, Andrei; Scott, Jeffery

2013-04-01

In this study, we investigate possible future climate change over Northern Eurasia and its impact on extreme events. Northern Eurasia is a major player in the global carbon budget because of boreal forests and peatlands. Circumpolar boreal forests alone contain more than five times the amount of carbon of temperate forests and almost double the amount of carbon of the world's tropical forests. Furthermore, severe permafrost degradation associated with climate change could result in peatlands releasing large amounts of carbon dioxide and methane. Meanwhile, changes in the frequency and magnitude of extreme events, such as extreme precipitation, heat waves or frost days are likely to have substantial impacts on Northern Eurasia ecosystems. For this reason, it is very important to quantify the possible climate change over Northern Eurasia under different emissions scenarios, while accounting for the uncertainty in the climate response and changes in extreme events. For several decades, the Massachusetts Institute of Technology (MIT) Joint Program on the Science and Policy of Global Change has been investigating uncertainty in climate change using the MIT Integrated Global System Model (IGSM) framework, an integrated assessment model that couples an earth system model of intermediate complexity (with a 2D zonal-mean atmosphere) to a human activity model. In this study, regional change is investigated using the MIT IGSM-CAM framework that links the IGSM to the National Center for Atmospheric Research (NCAR) Community Atmosphere Model (CAM). New modules were developed and implemented in CAM to allow climate parameters to be changed to match those of the IGSM. The simulations presented in this paper were carried out for two emission scenarios, a "business as usual" scenario and a 660 ppm of CO2-equivalent stabilization, which are similar to, respectively, the Representative Concentration Pathways RCP8.5 and RCP4.5 scenarios. Values of climate sensitivity and net aerosol forcing used in the simulations within the IGSM-CAM framework provide a good approximation for the median, and the lower and upper bound of 90% probability distribution of 21st century climate change. Five member ensembles were carried out for each choice of parameters using different initial conditions. With these simulations, we investigate the role of emissions scenarios (climate policies), the global climate response (climate sensitivity) and natural variability (initial conditions) on the uncertainty in future climate changes over Northern Eurasia. A particular emphasis is made on future changes in extreme events, including frost days, extreme summer temperature and extreme summer and winter precipitation.

What We Can Learn about Strategies, Language Learning, and Life from Two Extreme Cases: The Role of Well-Being Theory

ERIC Educational Resources Information Center

Oxford, Rebecca L.

2014-01-01

This article presents two foreign or second language (L2) learner histories representing the extreme ends of the spectrum of learner well-being. One story reflects the very positive learning experiences of a highly strategic learner, while the other story focuses on a less strategic learner's negative, long-lasting responses to a single traumatic…

Roy's Adaptation Model-Guided Education and Promoting the Adaptation of Veterans With Lower Extremities Amputation.

PubMed

Azarmi, Somayeh; Farsi, Zahra

2015-10-01

Any defect in extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on promoting the adaptation of veterans with lower extremities amputation. In a randomized clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of veterans clinic in Tehran, Iran, were recruited with convenience method and were randomly assigned to intervention and control groups during 2013 - 2014. For data collection, Roy's adaptation model questionnaire was used. After completing the questionnaires in both groups, maladaptive behaviors were determined in the intervention group and an education program based on Roy's adaptation model was implemented. After two months, both groups completed the questionnaires again. Data was analyzed with SPSS software. Independent t-test showed statistically significant differences between the two groups in the post-test stage in terms of the total score of adaptation (P = 0.001) as well as physiologic (P = 0.0001) and role function modes (P = 0.004). The total score of adaptation (139.43 ± 5.45 to 127.54 ± 14.55, P = 0.006) as well as the scores of physiologic (60.26 ± 5.45 to 53.73 ± 7.79, P = 0.001) and role function (20.30 ± 2.42 to 18.13 ± 3.18, P = 0.01) modes in the intervention group significantly increased, whereas the scores of self-concept (42.10 ± 4.71 to 39.40 ± 5.67, P = 0.21) and interdependence (16.76 ± 2.22 to 16.30 ± 2.57, P = 0.44) modes in the two stages did not have a significant difference. Findings of this research indicated that the Roy's adaptation model-guided education promoted the adaptation level of physiologic and role function modes in veterans with lower extremities amputation. However, this intervention could not promote adaptation in self-concept and interdependence modes. More intervention is advised based on Roy's adaptation model for improving the adaptation of veterans with lower extremities.

Characteristics of atmospheric circulation patterns associated with extreme temperatures over North America in observations and climate models

NASA Astrophysics Data System (ADS)

Loikith, Paul C.

Motivated by a desire to understand the physical mechanisms involved in future anthropogenic changes in extreme temperature events, the key atmospheric circulation patterns associated with extreme daily temperatures over North America in the current climate are identified. Several novel metrics are used to systematically identify and describe these patterns for the entire continent. The orientation, physical characteristics, and spatial scale of these circulation patterns vary based on latitude, season, and proximity to important geographic features (i.e., mountains, coastlines). The anomaly patterns associated with extreme cold events tend to be similar to, but opposite in sign of, those associated with extreme warm events, especially within the westerlies, and tend to scale with temperature in the same locations. The influence of the Pacific North American (PNA) pattern, the Northern Annular Mode (NAM), and the El Niño-Southern Oscillation (ENSO) on extreme temperature days and months shows that associations between extreme temperatures and the PNA and NAM are stronger than associations with ENSO. In general, the association with extremes tends to be stronger on monthly than daily time scales. Extreme temperatures are associated with the PNA and NAM in locations typically influenced by these circulation patterns; however many extremes still occur on days when the amplitude and polarity of these patterns do not favor their occurrence. In winter, synoptic-scale, transient weather disturbances are important drivers of extreme temperature days; however these smaller-scale events are often concurrent with amplified PNA or NAM patterns. Associations are weaker in summer when other physical mechanisms affecting the surface energy balance, such as anomalous soil moisture content, are associated with extreme temperatures. Analysis of historical runs from seventeen climate models from the CMIP5 database suggests that most models simulate realistic circulation patterns associated with extreme temperature days in most places. Model-simulated patterns tend to resemble observed patterns better in the winter than the summer and at 500 hPa than at the surface. There is substantial variability among the suite of models analyzed and most models simulate circulation patterns more realistically away from influential features such as large bodies of water and complex topography.

The Influence of the Madden-Julian Oscillation (mjo) on Extreme Rainfall Over the Central and Southern Peruvian Andes

NASA Astrophysics Data System (ADS)

Heidinger, H.; Jones, C.; Carvalho, L. V.

2015-12-01

Extreme rainfall is important for the Andean region because of the large contribution of these events to the seasonal totals and consequent impacts on water resources for agriculture, water consumption, industry and hydropower generation, as well as the occurrence of floods and landslides. Over Central and Southern Peruvian Andes (CSPA), rainfall exceeding the 90th percentile contributed between 44 to 100% to the total Nov-Mar 1979-2010 rainfall. Additionally, precipitation from a large majority of stations in the CSPA exhibits statistically significant spectral peaks on intraseasonal time-scales (20 to 70 days). The Madden-Julian Oscillation (MJO) is the most important intraseasonal mode of atmospheric circulation and moist convection in the tropics and the occurrence of extreme weather events worldwide. Mechanisms explaining the relationships between the MJO and precipitation in the Peruvian Andes have not been properly described yet. The present study examines the relationships between the activity and phases of the MJO and the occurrence of extreme rainfall over the CSPA. We found that the frequency of extreme rainfall events increase in the CSPA when the MJO is active. MJO phases 5, 6 and 7 contribute to the overall occurrence of extreme rainfall events over the CSPA. However, how the MJO phases modulate extreme rainfall depends on the location of the stations. For instance, extreme precipitation (above the 90th percentile) in stations in the Amazon basin are slightly more sensitive to phases 2, 3 and 4; the frequency of extremes in stations in the Pacific basin increases in phases 5, 6 and 7 whereas phase 2, 3 and 7 modulates extreme precipitation in stations in the Titicaca basin. Greater variability among stations is observed when using the 95th and 99th percentiles to identify extremes. Among the main mechanisms that explain the increase in extreme rainfall events in the Peruvian Andes is the intensification of the easterly moisture flux anomalies, which are favored during certain phases of the MJO. Here dynamical mechanisms linking the MJO to the occurrence of extreme rainfall in stations in the Peruvian Andes are investigated using composites of integrated moisture flux and geopotential height anomalies.

Cognitive development in 7- to 24-month-old extremely/very-to-moderately/late preterm and full-term born infants: The mediating role of focused attention.

PubMed

Reuner, Gitta; Weinschenk, Andrea; Pauen, Sabina; Pietz, Joachim

2015-01-01

The present study analyzed the links between prematurity, attention, and global cognitive performance in infancy and early childhood. At 7 months, focused attention (FA) was examined with an object examination task in 93 preterm infants (39 of them born extremely/very preterm, 54 born moderately/late preterm, and 38 infants born full-term). Global cognition was assessed at 7 and 24 months with the Bayley-II cognitive scale. Groups did not differ with respect to global cognitive performance but FA of infants born extremely/very preterm was significantly lower than in infants born moderately/late preterm. FA correlated significantly with both prematurity and cognitive performance at 7 months of age but not with global cognition in childhood. Findings point to a subtle adverse effect of prematurity on early attention and reveal evidence for the mediating role of FA on the effect of prematurity on cognition.

Arctic daily temperature and precipitation extremes: Observed and simulated physical behavior

NASA Astrophysics Data System (ADS)

Glisan, Justin Michael

Simulations using a six-member ensemble of Pan-Arctic WRF (PAW) were produced on two Arctic domains with 50-km resolution to analyze precipitation and temperature extremes for various periods. The first study used a domain developed for the Regional Arctic Climate Model (RACM). Initial simulations revealed deep atmospheric circulation biases over the northern Pacific Ocean, manifested in pressure, geopotential height, and temperature fields. Possible remedies to correct these large biases, such as modifying the physical domain or using different initial/boundary conditions, were unsuccessful. Spectral (interior) nudging was introduced as a way of constraining the model to be more consistent with observed behavior. However, such control over numerical model behavior raises concerns over how much nudging may affect unforced variability and extremes. Strong nudging may reduce or filter out extreme events, since the nudging pushes the model toward a relatively smooth, large-scale state. The question then becomes---what is the minimum spectral nudging needed to correct biases while not limiting the simulation of extreme events? To determine this, we use varying degrees of spectral nudging, using WRF's standard nudging as a reference point during January and July 2007. Results suggest that there is a marked lack of sensitivity to varying degrees of nudging. Moreover, given that nudging is an artificial forcing applied in the model, an important outcome of this work is that nudging strength apparently can be considerably smaller than WRF's standard strength and still produce reliable simulations. In the remaining studies, we used the same PAW setup to analyze daily precipitation extremes simulated over a 19-year period on the CORDEX Arctic domain for winter and summer. We defined these seasons as the three-month period leading up to and including the climatological sea ice maximum and minimum, respectively. Analysis focused on four North American regions defined using climatological records, regional weather patterns, and geographical/topographical features. We compared simulated extremes with those occurring at corresponding observing stations in the U.S. National Climate Data Center's (NCDC's) Global Summary of the Day. Our analysis focused on variations in features of the extremes such as magnitudes, spatial scales, and temporal regimes. Using composites of extreme events, we also analyzed the processes producing these extremes, comparing circulation, pressure, temperature and humidity fields from the ERA-Interim reanalysis and the model output. The analysis revealed the importance of atmospheric convection in the Arctic for some extreme precipitation events and the overall importance of topographic precipitation. The analysis established the physical credibility of the simulations for extreme behavior, laying a foundation for examining projected changes in extreme precipitation. It also highlighted the utility of the model for extracting behavior that one cannot discern directly from the observations, such as summer convective precipitation.

Generalized extreme gust wind speeds distributions

USGS Publications Warehouse

Cheng, E.; Yeung, C.

2002-01-01

Since summer 1996, the US wind engineers are using the extreme gust (or 3-s gust) as the basic wind speed to quantify the destruction of extreme winds. In order to better understand these destructive wind forces, it is important to know the appropriate representations of these extreme gust wind speeds. Therefore, the purpose of this study is to determine the most suitable extreme value distributions for the annual extreme gust wind speeds recorded in large selected areas. To achieve this objective, we are using the generalized Pareto distribution as the diagnostic tool for determining the types of extreme gust wind speed distributions. The three-parameter generalized extreme value distribution function is, thus, reduced to either Type I Gumbel, Type II Frechet or Type III reverse Weibull distribution function for the annual extreme gust wind speeds recorded at a specific site.With the considerations of the quality and homogeneity of gust wind data collected at more than 750 weather stations throughout the United States, annual extreme gust wind speeds at selected 143 stations in the contiguous United States were used in the study. ?? 2002 Elsevier Science Ltd. All rights reserved.

Core stability: implications for dance injuries.

PubMed

Rickman, Ashley M; Ambegaonkar, Jatin P; Cortes, Nelson

2012-09-01

Dancers experience a high incidence of injury due to the extreme physical demands of dancing. The majority of dance injuries are chronic in nature and occur in the lower extremities and low back. Researchers have indicated decreased core stability (CS) as a risk factor for these injuries. Although decreased CS is suggested to negatively affect lower extremity joint motion and lumbar control during activity, this relationship has not been extensively discussed in previous dance literature. Understanding the relationship between CS and injury risk is important to help reduce dance injury incidence and improve performance. The purposes of this review were to discuss: 1. the core and components of CS, 2. the relationship between CS and injury, 3. CS assessment techniques, and 4. future dance CS research areas. CS is the integration of passive (non-contractile), active (contractile), and neural structures to minimize the effects of external forces and maintain stability. CS is maintained by a combination of muscle power, strength, endurance, and sensory-motor control of the lumbopelvic-hip complex. CS assessments include measuring muscle strength and power using maximal voluntary isometric and isokinetic contractions and measuring endurance using the Biering-Sorensen, plank, and lateral plank tests. Measuring sensory-motor control requires specialized equipment (e.g., balance platforms). Overall, limited research has comprehensively examined all components of CS together and their relationships to injury. Rather, previous researchers have separately examined core power, strength, endurance, or sensory-motor control. Future researchers should explore the multifactorial role of CS in reducing injury risk and enhancing performance in dancers.

Quantifying the influence of global warming on unprecedented extreme climate events

PubMed Central

Singh, Deepti; Horton, Daniel E.; Swain, Daniel L.; Touma, Danielle; Charland, Allison; Liu, Yunjie; Haugen, Matz; Tsiang, Michael; Rajaratnam, Bala

2017-01-01

Efforts to understand the influence of historical global warming on individual extreme climate events have increased over the past decade. However, despite substantial progress, events that are unprecedented in the local observational record remain a persistent challenge. Leveraging observations and a large climate model ensemble, we quantify uncertainty in the influence of global warming on the severity and probability of the historically hottest month, hottest day, driest year, and wettest 5-d period for different areas of the globe. We find that historical warming has increased the severity and probability of the hottest month and hottest day of the year at >80% of the available observational area. Our framework also suggests that the historical climate forcing has increased the probability of the driest year and wettest 5-d period at 57% and 41% of the observed area, respectively, although we note important caveats. For the most protracted hot and dry events, the strongest and most widespread contributions of anthropogenic climate forcing occur in the tropics, including increases in probability of at least a factor of 4 for the hottest month and at least a factor of 2 for the driest year. We also demonstrate the ability of our framework to systematically evaluate the role of dynamic and thermodynamic factors such as atmospheric circulation patterns and atmospheric water vapor, and find extremely high statistical confidence that anthropogenic forcing increased the probability of record-low Arctic sea ice extent. PMID:28439005

Thermoregulatory value of cracking-clay soil shelters for small vertebrates during extreme desert conditions.

PubMed

Waudby, Helen P; Petit, Sophie

2017-05-01

Deserts exhibit extreme climatic conditions. Small desert-dwelling vertebrates have physiological and behavioral adaptations to cope with these conditions, including the ability to seek shelter. We investigated the temperature (T) and relative humidity (RH) regulating properties of the soil cracks that characterize the extensive cracking-clay landscapes of arid Australia, and the extent of their use by 2 small marsupial species: fat-tailed and stripe-faced dunnarts (Sminthopsis crassicaudata and Sminthopsis macroura). We measured hourly (over 24-h periods) the T and RH of randomly-selected soil cracks compared to outside conditions, during 2 summers and 2 winters. We tracked 17 dunnarts (8 Sminthopsis crassicaudata and 9 Sminthopsis macroura) to quantify their use of cracks. Cracks consistently moderated microclimate, providing more stable conditions than available from non-crack points, which often displayed comparatively dramatic fluctuations in T and RH. Both dunnart species used crack shelters extensively. Cracks constitute important shelter for small animals during extreme conditions by providing a stable microclimate, which is typically cooler than outside conditions in summer and warmer in winter. Cracks likely play a fundamental sheltering role by sustaining the physiological needs of small mammal populations. Globally, cracking-clay areas are dominated by agricultural land uses, including livestock grazing. Management of these systems should focus not only on vegetation condition, but also on soil integrity, to maintain shelter resources for ground-dwelling fauna. © 2016 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

The Limits of Life in the Deep Subsurface - Implications for the Origin of Life

NASA Astrophysics Data System (ADS)

Baross, John

2013-06-01

There are very few environments on Earth where life is absent. Microbial life has proliferated into habitats that span nearly every imaginable physico-chemical variable. Only the availability of liquid water and temperature are known to prevent the growth of organisms. The other extreme physical and chemical variables, such as pH, pressure, high concentrations of solutes, damaging radiation, and toxic metals, are life-prohibiting factors for most organisms but not for all. The deep subsurface environments span all of the extreme conditions encountered by life including habitat conditions not yet explored, such as those that combine high temperature, high and low pH and extreme pressures. Some of the ``extremophile'' microorganisms inhabiting the deep subsurface environments have been shown to be among the most ``ancient'' of extant life. Their genomes and physiologies have led to a broader understanding of the geological settings of early life, the most ancient energy pathways, and the importance of water/rock interactions and tectonics in the origin and early evolution of life. The case can now be made that deep subsurface environments contributed to life's origin and provided the habitat(s) for the earliest microbial communities. However, there is much more to be done to further our understanding on the role of moderate to high pressures and temperatures on the chemical and biochemical ``steps'' leading to life, and on the evolution and physiology of both ancient and present-day subsurface microbial communities.

Quantifying the influence of global warming on unprecedented extreme climate events.

PubMed

Diffenbaugh, Noah S; Singh, Deepti; Mankin, Justin S; Horton, Daniel E; Swain, Daniel L; Touma, Danielle; Charland, Allison; Liu, Yunjie; Haugen, Matz; Tsiang, Michael; Rajaratnam, Bala

2017-05-09

Efforts to understand the influence of historical global warming on individual extreme climate events have increased over the past decade. However, despite substantial progress, events that are unprecedented in the local observational record remain a persistent challenge. Leveraging observations and a large climate model ensemble, we quantify uncertainty in the influence of global warming on the severity and probability of the historically hottest month, hottest day, driest year, and wettest 5-d period for different areas of the globe. We find that historical warming has increased the severity and probability of the hottest month and hottest day of the year at >80% of the available observational area. Our framework also suggests that the historical climate forcing has increased the probability of the driest year and wettest 5-d period at 57% and 41% of the observed area, respectively, although we note important caveats. For the most protracted hot and dry events, the strongest and most widespread contributions of anthropogenic climate forcing occur in the tropics, including increases in probability of at least a factor of 4 for the hottest month and at least a factor of 2 for the driest year. We also demonstrate the ability of our framework to systematically evaluate the role of dynamic and thermodynamic factors such as atmospheric circulation patterns and atmospheric water vapor, and find extremely high statistical confidence that anthropogenic forcing increased the probability of record-low Arctic sea ice extent.

Quantifying the Influence of Global Warming on Unprecedented Extreme Climate Events

NASA Technical Reports Server (NTRS)

Diffenbaugh, Noah S.; Singh, Deepti; Mankin, Justin S.; Horton, Daniel E.; Swain, Daniel L.; Touma, Danielle; Charland, Allison; Liu, Yunjie; Haugen, Matz; Tsiang, Michael;

Preface: Impacts of extreme climate events and disturbances on carbon dynamics

USGS Publications Warehouse

Xiao, Jingfeng; Liu, Shuguang; Stoy, Paul C.

2016-01-01

The impacts of extreme climate events and disturbances (ECE&D) on the carbon cycle have received growing attention in recent years. This special issue showcases a collection of recent advances in understanding the impacts of ECE&D on carbon cycling. Notable advances include quantifying how harvesting activities impact forest structure, carbon pool dynamics, and recovery processes; observed drastic increases of the concentrations of dissolved organic carbon and dissolved methane in thermokarst lakes in western Siberia during a summer warming event; disentangling the roles of herbivores and fire on forest carbon dioxide flux; direct and indirect impacts of fire on the global carbon balance; and improved atmospheric inversion of regional carbon sources and sinks by incorporating disturbances. Combined, studies herein indicate several major research needs. First, disturbances and extreme events can interact with one another, and it is important to understand their overall impacts and also disentangle their effects on the carbon cycle. Second, current ecosystem models are not skillful enough to correctly simulate the underlying processes and impacts of ECE&D (e.g., tree mortality and carbon consequences). Third, benchmark data characterizing the timing, location, type, and magnitude of disturbances must be systematically created to improve our ability to quantify carbon dynamics over large areas. Finally, improving the representation of ECE&D in regional climate/earth system models and accounting for the resulting feedbacks to climate are essential for understanding the interactions between climate and ecosystem dynamics.

A Novel, Extremely Elongated, and Endocellular Bacterial Symbiont Supports Cuticle Formation of a Grain Pest Beetle.

PubMed

Hirota, Bin; Okude, Genta; Anbutsu, Hisashi; Futahashi, Ryo; Moriyama, Minoru; Meng, Xian-Ying; Nikoh, Naruo; Koga, Ryuichi; Fukatsu, Takema

2017-09-26

The saw-toothed grain beetle, Oryzaephilus surinamensis (Silvanidae), is a cosmopolitan stored-product pest. Early studies on O. surinamensis in the 1930s described the presence of peculiar bacteriomes harboring endosymbiotic bacteria in the abdomen. Since then, however, the microbiological nature of the symbiont has been elusive. Here we investigated the endosymbiotic system of O. surinamensis in detail. In the abdomen of adults, pupae, and larvae, four oval bacteriomes were consistently identified, whose cytoplasm was full of extremely elongated tubular bacterial cells several micrometers wide and several hundred micrometers long. Molecular phylogenetic analysis identified the symbiont as a member of the Bacteroidetes , in which the symbiont was the most closely related to the endosymbiont of a grain pest beetle, Rhyzopertha dominica (Bostrichidae). The symbiont was detected in developing embryos, corroborating vertical symbiont transmission through host generations. The symbiont gene showed AT-biased nucleotide composition and accelerated molecular evolution, plausibly reflecting degenerative evolution of the symbiont genome. When the symbiont infection was experimentally removed, the aposymbiotic insects grew and reproduced normally, but exhibited a slightly but significantly more reddish cuticle and lighter body mass. These results indicate that the symbiont of O. surinamensis is not essential for the host's growth and reproduction but contributes to the host's cuticle formation. Symbiont genome sequencing and detailed comparison of fitness parameters between symbiotic and aposymbiotic insects under various environmental conditions will provide further insights into the symbiont's biological roles for the stored-product pest. IMPORTANCE Some beetles notorious as stored-product pests possess well-developed symbiotic organs called bacteriomes for harboring specific symbiotic bacteria, although their biological roles have been poorly understood. Here we report a peculiar endosymbiotic system of a grain pest beetle, Oryzaephilus surinamensis , in which four oval bacteriomes in the abdomen are full of extremely elongated tubular bacterial cells. Experimental symbiont elimination did not hinder the host's growth and reproduction, but resulted in emergence of reddish beetles, uncovering the symbiont's involvement in host's cuticle formation. We speculate that the extremely elongated symbiont cell morphology might be due to the degenerative symbiont genome deficient in bacterial cell division and/or cell wall formation, which highlights an evolutionary consequence of intimate host-symbiont coevolution. Copyright © 2017 Hirota et al.

Kinematic and Kinetic Profiles of Trunk and Lower Limbs during Baseball Pitching in Collegiate Pitchers

PubMed Central

Kageyama, Masahiro; Sugiyama, Takashi; Takai, Yohei; Kanehisa, Hiroaki; Maeda, Akira

2014-01-01

The purpose of this study was to clarify differences in the kinematic and kinetic profiles of the trunk and lower extremities during baseball pitching in collegiate baseball pitchers, in relation to differences in the pitched ball velocity. The subjects were 30 collegiate baseball pitchers aged 18 to 22 yrs, who were assigned to high- (HG, 37.4 ± 0.8 m·s-1) and low-pitched-ball-velocity groups (LG, 33.3 ± 0.8 m·s-1). Three-dimensional motion analysis with a comprehensive lower-extremity model was used to evaluate kinematic and kinetic parameters during baseball pitching. The ground-reaction forces (GRF) of the pivot and stride legs during pitching were determined using two multicomponent force plates. The joint torques of hip, knee, and ankle were calculated using inverse-dynamics computation of a musculoskeletal human model. To eliminate any effect of variation in body size, kinetic and GRF data were normalized by dividing them by body mass. The maxima and minima of GRF (Fy, Fz, and resultant forces) on the pivot and stride leg were significantly greater in the HG than in the LG (p < 0.05). Furthermore, Fy, Fz, and resultant forces on the stride leg at maximum shoulder external rotation and ball release were significantly greater in the HG than in the LG (p < 0.05). The hip abduction, hip internal rotation and knee extension torques of the pivot leg and the hip adduction torque of the stride leg when it contacted the ground were significantly greater in the HG than in the LG (p < 0.05). These results indicate that, compared with low-ball-velocity pitchers, high-ball-velocity pitchers can generate greater momentum of the lower limbs during baseball pitching. Key points High-ball-velocity pitchers are characterized by greater momentum of the lower limbs during pitching motion. For high-pitched-ball velocity, stabilizing lower limbs during pitching plays an important role in order to increase the rotation and forward motion of the trunk. Computation of the lower-extremity kinetics and measurement of lower-extremity strength may help clarify the role of muscle strength in determining knee and hip function in baseball pitching. PMID:25435765

Modelling Precipitation and Temperature Extremes: The Importance of Horizontal Resolution

NASA Astrophysics Data System (ADS)

Shields, C. A.; Kiehl, J. T.; Meehl, G. A.

2013-12-01

Understanding Earth's water cycle on a warming planet is of critical importance in society's ability to adapt to climate change. Extreme weather events, such as floods, heat waves, and drought will likely change with the water cycle as greenhouse gases continue to rise. Location, duration, and intensity of extreme events can be studied using complex earth system models. Here, we employ the fully coupled Community Earth System Model (CESM1.0) to evaluate extreme event impacts for different possible future forcing scenarios. Simulations applying the Representative Concentration Pathway (RCP) scenarios 2.6 and 8.5 were chosen to bracket the range of model responses. Because extreme weather events happen on a regional scale, there is a tendency to favor using higher resolution models, i.e. models that can represent regional features with greater accuracy. Within the CESM1.0 framework, we evaluate both the standard 1 degree resolution (1 degree atmosphere/land coupled to 1 degree ocean/sea ice), and the higher 0.5 degree resolution version (0.5 degree atmosphere/land coupled to 1 degree ocean/sea ice), focusing on extreme precipitation events, heat waves, and droughts. We analyze a variety of geographical regions, but generally find that benefits from increased horizontal resolution are most significant on the regional scale.

Sex-Role Attitude Change of Young Women: Influential Factors from a Panel Study.

ERIC Educational Resources Information Center

Tallichet, Suzanne E.; Willits, Fern K.

A panel of 294 non-metropolitan Pennsylvania women was studied first in 1970 when they were high school sophomores and again in 1981 to assess the relationship between traditional and nontraditional role behaviors and changes in sex-role attitudes. As adolescents in 1970, the women were either extremely liberal or traditional. As young adults in…

Extreme Geohazards: Reducing Disaster Risk and Increasing Resilience

NASA Astrophysics Data System (ADS)

Plag, Hans-Peter; Stein, Seth; Brocklebank, Sean; Jules-Plag, Shelley; Campus, Paola

2014-05-01

Extreme natural hazards have the potential to cause global disasters and to lead to an escalation of the global sustainability crisis. Floods and droughts pose threats that could reach planetary extent, particularly through secondary economic and social impacts. Earthquakes and tsunamis cause disasters that could exceed the immediate coping capacity of the global economy, particularly in hazardous areas containing megacities, that can be particularly vulnerable to natural hazards if proper emergency protocols and infrastructures are not set in place. Recent events illustrate the destruction extreme hazards can inflict, both directly and indirectly, through domino effects resulting from the interaction with the built environment. Unfortunately, the more humanity learns to cope with relatively frequent (50 to 100 years) natural hazard events, the less concerns remain about the low-probability (one in a few hundred or more years) high-impact events. As a consequence, threats from low-probability extreme floods, droughts, and volcanic eruptions are not appropriately accounted for in Disaster Risk Reduction (DRR) discussions. With the support of the European Science Foundation (ESF), the Geohazards Community of Practice (GHCP) of the Group on Earth Observations (GEO) has developed a White Paper (WP) on the risk associated with low-probability, high-impact geohazards. These events are insufficiently addressed in risk management, although their potential impacts are comparable to those of a large asteroid impact, a global pandemic, or an extreme drought. The WP aims to increase awareness of the risk associated with these events as a basis for a comprehensive risk management. Extreme geohazards have occurred regularly throughout the past, but mostly did not cause major disasters because the exposure of human assets to such hazards and the global population density were much lower than today. The most extreme events during the last 2,000 years would cause today unparalleled damage on a global scale for a globally connected and stressed society. In particular, large volcanic eruptions could impact climate, damage anthropogenic infrastructure and interrupt resource supplies on a global scale. The occurrence of one or more of the largest volcanic eruptions that took place during the last 2,000 years under today's conditions would likely cause global disasters or catastrophes challenging civilization. Integration of these low-probability, high-impact events in DRR requires an approach focused on resilience and antifragility, as well as the ability to cope with, and recover from failure of infrastructures and social systems. Resilience results from social capital even more than from the robustness of infrastructure. While it is important to understand the hazards through the contribution of geosciences, it is equally important to understand through the contribution of social sciences and engineering the societal processes involved with coping with hazards or leading to failure. For comprehensive development of resilience to natural hazards and, in particular, extreme geohazards, synergy between geosciences, engineering and social sciences, jointed to an improved science-policy relationship is key to success. For example, a simple cost-benefit analysis shows that a comprehensive monitoring system that could identify the onset of an extreme volcanic eruption with sufficient lead time to allow for a globally coordinated preparation makes economic sense. The WP recommends implementation of such a monitoring system with global coverage, assesses the existing assets in current monitoring systems, and illustrates many benefits, besides providing early warning for extreme volcanic eruptions. However, such a monitoring system can provide resilience only via the capability of the global community to react to early warnings. The WP recommends achieving this through the establishment of a global coordination platform comparable to IPCC's role in addressing climate-change related issues to assess knowledge and related adaptive capabilities for disasters due to extreme geohazards.

Identifying and Clarifying Organizational Values.

ERIC Educational Resources Information Center

Seevers, Brenda S.

2000-01-01

Of the 14 organizational values ranked by a majority of 146 New Mexico Cooperative Extension educators as extremely valued, 9 were extremely evident in organizational policies and procedures. A values audit such as this forms an important initial step in strategic planning. (SK)

A dynamical systems approach to studying midlatitude weather extremes

NASA Astrophysics Data System (ADS)

Messori, Gabriele; Caballero, Rodrigo; Faranda, Davide

2017-04-01

Extreme weather occurrences carry enormous social and economic costs and routinely garner widespread scientific and media coverage. The ability to predict these events is therefore a topic of crucial importance. Here we propose a novel predictability pathway for extreme events, by building upon recent advances in dynamical systems theory. We show that simple dynamical systems metrics can be used to identify sets of large-scale atmospheric flow patterns with similar spatial structure and temporal evolution on time scales of several days to a week. In regions where these patterns favor extreme weather, they afford a particularly good predictability of the extremes. We specifically test this technique on the atmospheric circulation in the North Atlantic region, where it provides predictability of large-scale wintertime surface temperature extremes in Europe up to 1 week in advance.

Summary of presentation for research on social structure, agreement, and conflict in groups in extreme and isolated environments

NASA Technical Reports Server (NTRS)

1990-01-01

Despite a vast amount of research, little is known concerning the effect of group structure, and individuals' understanding of that structure, on conflict in Antarctic groups. The overall objective of the research discussed is to determine the interrelationships of group structure, social cognition, and group function and conflict in isolated and extreme environments. In the two decades following WWII, a large body of research focused on the physiological, psychological, and social psychological factors affecting the functioning of individuals and groups in a variety of extreme and isolated environments in both the Arctic and Antarctic. There are two primary reasons for further research of this type. First, Antarctic polar stations are considered to be natural laboratories for the social and behavioral sciences and provide an opportunity to address certain theoretical and empirical questions concerned with agreement and conflict in social groups in general and group behavior in extreme, isolated environments in particular. Recent advances in the analysis of social networks and intracultural variation have improved the methods and have shifted the theoretical questions. The research is motivated by three classes of questions: (1) What are the characteristics of the social relations among individuals working and living together in extreme and isolated environments?; (2) What do individuals understand about their group, how does that understanding develop, and how is it socially distributed?; and (3) What is the relationship between that understanding and the functioning of the social group? Answers to these questions are important if we are to advance our knowledge of how individuals and groups adapt to extreme environments. Second, although Antarctic winter-over candidates may be evaluated as qualified on the basis of individual characteristics, they may fail to adapt because of certain characteristics of the social group. Consequently, the ability of winter-over-groups to adapt to these extreme conditions has varied dramatically from year to year. In the past, differences in personality, background, and social status have led to conflicts between individuals or cliques precipitating, in turn, an overall decline in morale, failure to accomplish work tasks, and increases in insomnia, depression, anxiety, and alcohol abuse. A better understanding of the role of group structure and social cognition in processes of group adaptation and conflict in Antarctica would contribute towards the revision of existing screening methods, potentially leading to a reduction of group conflict and improved performance of scientific research and support activities. An improved screening protocol for the Antarctic would also have applications for other isolated environments such as scientific outposts and the proposed NASA space station. In sum, this research will (1) contribute significantly to our theoretical understanding of the role of social structure and cognition in the functioning of groups in isolation; (2) complement current work on health and adaptation in polar environments; and (3) provide for models of the formation of group structure that will aid in the development of improved procedures for assembling groups for the Antarctic and other isolated environments (e.g., space stations).

Global meteorological influences on the record UK rainfall of winter 2013-14

NASA Astrophysics Data System (ADS)

Knight, Jeff R.; Maidens, Anna; Watson, Peter A. G.; Andrews, Martin; Belcher, Stephen; Brunet, Gilbert; Fereday, David; Folland, Chris K.; Scaife, Adam A.; Slingo, Julia

2017-07-01

The UK experienced record average rainfall in winter 2013-14, leading to widespread and prolonged flooding. The immediate cause of this exceptional rainfall was a very strong and persistent cyclonic atmospheric circulation over the North East Atlantic Ocean. This was related to a very strong North Atlantic jet stream which resulted in numerous damaging wind storms. These exceptional meteorological conditions have led to renewed questions about whether anthropogenic climate change is noticeably influencing extreme weather. The regional weather pattern responsible for the extreme UK winter coincided with highly anomalous conditions across the globe. We assess the contributions from various possible remote forcing regions using sets of ocean-atmosphere model relaxation experiments, where winds and temperatures are constrained to be similar to those observed in winter 2013-14 within specified atmospheric domains. We find that influences from the tropics were likely to have played a significant role in the development of the unusual extra-tropical circulation, including a role for the tropical Atlantic sector. Additionally, a stronger and more stable stratospheric polar vortex, likely associated with a strong westerly phase of the stratospheric Quasi-Biennial Oscillation (QBO), appears to have contributed to the extreme conditions. While intrinsic climatic variability clearly has the largest effect on the generation of extremes, results from an analysis which segregates circulation-related and residual rainfall variability suggest that emerging climate change signals made a secondary contribution to extreme rainfall in winter 2013-14.

Effects of extreme spring temperatures on phenology: a case study from Munich and Ingolstadt

NASA Astrophysics Data System (ADS)

Jochner, Susanne; Menzel, Annette

2010-05-01

Extreme events - e.g. warm spells or heavy precipitation events - are likely to increase in the future both in frequency and intensity. Therefore, research on extreme events gains new importance; also in terms of plant development which is mostly triggered by temperatures. An arising question is how plants respond to an extreme warm spell when following an extreme cold winter season. This situation could be studied in spring 2009 in the greater area of Munich and Ingolstadt by phenological observations of flowering and leaf unfolding of birch (Betula pendula L.) and flowering of horse chestnut (Aesculus hippocastanum L.). The long chilling period of winter 2008 and spring 2009 was followed by an immediate strong forcing of flowering and leaf unfolding, especially for birch. This extreme weather situation diminished the difference between urban and rural dates of onset. Another important fact that could be observed in the proceeding period of December 2008 to April 2009 was the reduced temperature difference among urban and rural sites (urban heat island effect). Long-term observations (1951-2008) of the phenological network of the German Meteorological Service (DWD) were used to identify years with reduced urban-rural differences between onset times in the greater area of Munich in the past. Statistical analyses were conducted in order to answer the question whether the sequence of extreme warm and cold events leads to a decreased difference in phenological onset times or if this behaviour can be attributed to extreme warm springs themselves or to the decreased urban heat island effect which is mostly affected by general atmospheric circulation patterns.

Scene text detection by leveraging multi-channel information and local context

NASA Astrophysics Data System (ADS)

Wang, Runmin; Qian, Shengyou; Yang, Jianfeng; Gao, Changxin

2018-03-01

As an important information carrier, texts play significant roles in many applications. However, text detection in unconstrained scenes is a challenging problem due to cluttered backgrounds, various appearances, uneven illumination, etc.. In this paper, an approach based on multi-channel information and local context is proposed to detect texts in natural scenes. According to character candidate detection plays a vital role in text detection system, Maximally Stable Extremal Regions(MSERs) and Graph-cut based method are integrated to obtain the character candidates by leveraging the multi-channel image information. A cascaded false positive elimination mechanism are constructed from the perspective of the character and the text line respectively. Since the local context information is very valuable for us, these information is utilized to retrieve the missing characters for boosting the text detection performance. Experimental results on two benchmark datasets, i.e., the ICDAR 2011 dataset and the ICDAR 2013 dataset, demonstrate that the proposed method have achieved the state-of-the-art performance.

Exploring the causal machinery behind sex ratios at birth: does hepatitis B play a role?

PubMed

Hamoudi, Amar

2010-01-01

The causal machinery underlying sex determination is directly relevant to many questions relating gender and family composition to social and economic outcomes. In recent work, Oster highlighted a correlation between parental hepatitis B carrier status and sex of the child. One of her analyses went further, speaking directly to causality. That analysis appeared to have answered an important question that had remained unresolved in medical and biological literatures—namely, does chronic infection with hepatitis B cause male‐skewed sex ratios at birth? Oster’s creative empirical analysis appeared to suggest that it does; however, in this article I reassess the result and present evidence that, at the very least, the question remains open. Further investigation into questions around the causal machinery of sex determination is warranted in the social science literature, as well as in that of biology and medicine. However, my results suggest that it is extremely unlikely that chronic hepatitis B infection plays a biologically significant role.

Biofilms in Endodontics-Current Status and Future Directions.

PubMed

Neelakantan, Prasanna; Romero, Monica; Vera, Jorge; Daood, Umer; Khan, Asad U; Yan, Aixin; Cheung, Gary Shun Pan

2017-08-11

Microbiota are found in highly organized and complex entities, known as biofilms, the characteristics of which are fundamentally different from microbes in planktonic suspensions. Root canal infections are biofilm mediated. The complexity and variability of the root canal system, together with the multi-species nature of biofilms, make disinfection of this system extremely challenging. Microbial persistence appears to be the most important factor for failure of root canal treatment and this could further have an impact on pain and quality of life. Biofilm removal is accomplished by a chemo-mechanical process, using specific instruments and disinfecting chemicals in the form of irrigants and/or intracanal medicaments. Endodontic research has focused on the characterization of root canal biofilms and the clinical methods to disrupt the biofilms in addition to achieving microbial killing. In this narrative review, we discuss the role of microbial biofilms in endodontics and review the literature on the role of root canal disinfectants and disinfectant-activating methods on biofilm removal.

On the role of ozone feedback in the ENSO amplitude response under global warming.

PubMed

Nowack, Peer J; Braesicke, Peter; Luke Abraham, N; Pyle, John A

2017-04-28

The El Niño-Southern Oscillation (ENSO) in the tropical Pacific Ocean is of key importance to global climate and weather. However, state-of-the-art climate models still disagree on the ENSO's response under climate change. The potential role of atmospheric ozone changes in this context has not been explored before. Here we show that differences between typical model representations of ozone can have a first-order impact on ENSO amplitude projections in climate sensitivity simulations. The vertical temperature gradient of the tropical middle-to-upper troposphere adjusts to ozone changes in the upper troposphere and lower stratosphere, modifying the Walker circulation and consequently tropical Pacific surface temperature gradients. We show that neglecting ozone changes thus results in a significant increase in the number of extreme ENSO events in our model. Climate modeling studies of the ENSO often neglect changes in ozone. We therefore highlight the need to understand better the coupling between ozone, the tropospheric circulation, and climate variability.

Induction and function of virus-specific CD4+ T cell responses

PubMed Central

Whitmire, Jason K.

2010-01-01

CD4+ T cells -- often referred to as T-helper cells -- play a central role in immune defense and pathogenesis. Virus infections and vaccines stimulate and expand populations of antigen-specific CD4+ T cells in mice and in man. These virus-specific CD4+ T cells are extremely important in antiviral protection: deficiencies in CD4+ T cells are associated with virus reactivation, generalized susceptibility to opportunistic infections, and poor vaccine efficacy. As described below, CD4+ T cells influence effector and memory CD8+ T cell responses, humoral immunity, and the antimicrobial activity of macrophages and are involved in recruiting cells to sites of infection. This review summarizes a few key points about the dynamics of the CD4+ T cell response to virus infection, the positive role of pro-inflammatory cytokines in the differentiation of virus-specific CD4+ T cells, and new areas of investigation to improve vaccines against virus infection. PMID:21236461

Biophysical properties of the human finger for touch comprehension: influences of ageing and gender

PubMed Central

Djaghloul, M.; Thieulin, C.; Vargiolu, R.; Pailler-Mattei, C. ; Zahouani, H.

2017-01-01

The human finger plays an extremely important role in tactile perception, but little is known about how age and gender affect its biophysical properties and their role in tactile perception. We combined studies on contact characteristics, mechanical properties and surface topography to understand age and gender effects on the human finger. The values obtained regarding contact characteristics (i.e. adhesive force) were significantly higher for women than for men. As for mechanical properties (i.e. Young's modulus E), a significant and positive correlation with age was observed and found to be higher for women. A positive correlation was observed between age and the arithmetic mean of surface roughness for men. However, an inverse age effect was highlighted for women. The age and gender effects obtained have never been reported previously in the literature. These results open new perspectives for understanding the weakening of tactile perception across ages and how it differs between men and women. PMID:28878982

Biofilms in Endodontics—Current Status and Future Directions

PubMed Central

Neelakantan, Prasanna; Romero, Monica; Vera, Jorge; Daood, Umer; Khan, Asad U.; Yan, Aixin; Cheung, Gary Shun Pan

2017-01-01

Microbiota are found in highly organized and complex entities, known as biofilms, the characteristics of which are fundamentally different from microbes in planktonic suspensions. Root canal infections are biofilm mediated. The complexity and variability of the root canal system, together with the multi-species nature of biofilms, make disinfection of this system extremely challenging. Microbial persistence appears to be the most important factor for failure of root canal treatment and this could further have an impact on pain and quality of life. Biofilm removal is accomplished by a chemo-mechanical process, using specific instruments and disinfecting chemicals in the form of irrigants and/or intracanal medicaments. Endodontic research has focused on the characterization of root canal biofilms and the clinical methods to disrupt the biofilms in addition to achieving microbial killing. In this narrative review, we discuss the role of microbial biofilms in endodontics and review the literature on the role of root canal disinfectants and disinfectant-activating methods on biofilm removal. PMID:28800075

1999 Bioastronomy Meeting

NASA Technical Reports Server (NTRS)

Meech, Karen J.; Caroff, Lawrence J. (Technical Monitor)

2001-01-01

The 6th Bioastronomy Conference, Bioastronomy '99: A New Era in Bioastronomy, was held at the Hapuna Prince Beach hotel on the Big Island of Hawaii from August 2-6, 1999. The series of previous Bioastronomy meetings have played an important role in integrating the broader interests and techniques of both astronomy and biology to understand the origin and evolution of living systems in the universe, and to generating a context for exploration in our solar system and in extrasolar planetary systems. The scope of these interdisciplinary fields is captured in the topics discussed at the meeting: organic molecules in interstellar and interplanetary space; origin and evolution of planetary systems; comets, asteroids, and other small bodies and their role in the origin and evolution of life; Earth as a living planet; extreme environments on Earth; origin of life; transport of life between planets; evolution of life and intelligence; detection and characterization of extrasolar planets; search for extraterrestrial technology and life; future missions; and public acceptance and support of scientific studies of life in the universe.

The photochemical reaction of hydrocarbons under extreme thermobaric conditions

NASA Astrophysics Data System (ADS)

Serovaiskii, Aleksandr; Kolesnikov, Anton; Mukhina, Elena; Kutcherov, Vladimir

2017-10-01

The photochemical reaction of hydrocarbons was found to play an important role in the experiments with the synthetic petroleum conducted in Diamond Anvil Cell (DAC). Raman spectroscopy with a green laser (514.5 nm) was used for in situ sample analysis. This photochemical effect was investigated in the pressure range of 0.7-5 GPa, in the temperature interval from the ambient conditions to 450°C. The power of laser used in these experiment series was from 0.05 W to 0.6 W. The chemical transformation was observed when the necessary threshold pressure (~2.8 GPa) was reached. This transformation correlated with the luminescence appearance on the Raman spectra and a black opaque spot in the sample was observed in the place where the laser focus was forwarded. The exposure time and laser power (at least in the 0.1-0.5 W range) did not play a role in the 0.1-0.5 GPa range.

Source selection problem of competitive power plants under government intervention: a game theory approach

NASA Astrophysics Data System (ADS)

Mahmoudi, Reza; Hafezalkotob, Ashkan; Makui, Ahmad

2014-06-01

Pollution and environmental protection in the present century are extremely significant global problems. Power plants as the largest pollution emitting industry have been the cause of a great deal of scientific researches. The fuel or source type used to generate electricity by the power plants plays an important role in the amount of pollution produced. Governments should take visible actions to promote green fuel. These actions are often called the governmental financial interventions that include legislations such as green subsidiaries and taxes. In this paper, by considering the government role in the competition of two power plants, we propose a game theoretical model that will help the government to determine the optimal taxes and subsidies. The numerical examples demonstrate how government could intervene in a competitive market of electricity to achieve the environmental objectives and how power plants maximize their utilities in each energy source. The results also reveal that the government's taxes and subsidiaries effectively influence the selected fuel types of power plants in the competitive market.

Adapting to extreme events related to natural variability and climate change: the imperative of coupling technology with strong regulation and governance.

PubMed

Kythreotis, A P; Mercer, T G; Frostick, L E

2013-09-03

In recent years there has been an increase in extreme events related to natural variability (such as earthquakes, tsunamis and hurricanes) and climate change (such as flooding and more extreme weather). Developing innovative technologies is crucial in making society more resilient to such events. However, little emphasis has been placed on the role of human decision-making in maximizing the positive impacts of technological developments. This is exacerbated by the lack of appropriate adaptation options and the privatization of existing infrastructure, which can leave people exposed to increasing risk. This work examines the need for more robust government regulation and legislation to complement developments and innovations in technology in order to protect communities against such extreme events.

Life in hot acid: Pathway analyses in extremely thermoacidophilic archaea

PubMed Central

Auernik, Kathryne S.; Cooper, Charlotte R.; Kelly, Robert M.

2013-01-01

SUMMARY The extremely thermoacidophilic archaea are a particularly intriguing group of microorganisms that must simultaneously cope with biologically extreme pHs (≤ 4) and temperatures (Topt ≥ 60°C) in their natural environments. Their expandi ng biotechnological significance relates to their role in biomining of base and precious metals and their unique mechanisms of survival in hot acid, at both the cellular and biomolecular levels. Recent developments, such as advances in understanding of heavy metal tolerance mechanisms, implementation of a genetic system, and discovery of a new carbon fixation pathway, have been facilitated by availability of genome sequence data and molecular genetic systems. As a result, new insights into the metabolic pathways and physiological features that define extreme thermoacidophily have been obtained, in some cases suggesting prospects for biotechnological opportunities. PMID:18760359

Microrefugia and Shifts of Hippophae tibetana (Elaeagnaceae) on the north side of Mt. Qomolangma (Mt. Everest) during the last 25000 years.

PubMed

Xu, Lu; Wang, Hao; La, Qiong; Lu, Fan; Sun, Kun; Fang, Yang; Yang, Mei; Zhong, Yang; Wu, Qianhong; Chen, Jiakuan; Birks, H John B; Zhang, Wenju

2014-01-01

Microrefugia at high altitudes or high latitudes are thought to play an important role in the post-glacial colonization of species. However, how populations in such microrefugia have responded to climate changes in alternating cold glacial and warm interglacial stages remain unclear. Here we present evidence to indicate the Rongbuk Valley of the Mt. Qomolangma (Mt. Everest) area, the highest region on earth, had microrefugia for Hippophae tibetana and discuss how this low shrub was adapted to the extreme climate fluctuations of the last 25,000 years by shifts. By integrating geological, glaciological, meteorological, and genetic information, we found that the Rongbuk Valley was not only a glacial microrefugium but also an interglacial microrefugium for H. tibetana: the former was located on the riverbank below 4800 m above sea level (asl) or lower area and the latter at ∼ 5000 m asl. Our results show that after the Last Glacial Maximum (LGM), H. tibetana in the valley has undergone upward and downward migrations around ∼ 5000 m driven by climate fluctuations and the population in the glacial microrefugium has suffered extinction or extreme contraction. Moreover, with the rise of temperature in the last four decades, the upper limit of H. tibetana has shifted at least 30 m upward. Combining population history and recent range shift of this species is important in predicting the fate of this endemic species to future climate changes.

Microrefugia and Shifts of Hippophae tibetana (Elaeagnaceae) on the North Side of Mt. Qomolangma (Mt. Everest) during the Last 25000 Years

PubMed Central

Lu, Fan; Sun, Kun; Fang, Yang; Yang, Mei; Zhong, Yang; Wu, Qianhong; Chen, Jiakuan; Birks, H. John B.; Zhang, Wenju

2014-01-01

Microrefugia at high altitudes or high latitudes are thought to play an important role in the post-glacial colonization of species. However, how populations in such microrefugia have responded to climate changes in alternating cold glacial and warm interglacial stages remain unclear. Here we present evidence to indicate the Rongbuk Valley of the Mt. Qomolangma (Mt. Everest) area, the highest region on earth, had microrefugia for Hippophae tibetana and discuss how this low shrub was adapted to the extreme climate fluctuations of the last 25,000 years by shifts. By integrating geological, glaciological, meteorological, and genetic information, we found that the Rongbuk Valley was not only a glacial microrefugium but also an interglacial microrefugium for H. tibetana: the former was located on the riverbank below 4800 m above sea level (asl) or lower area and the latter at ∼5000 m asl. Our results show that after the Last Glacial Maximum (LGM), H. tibetana in the valley has undergone upward and downward migrations around ∼5000 m driven by climate fluctuations and the population in the glacial microrefugium has suffered extinction or extreme contraction. Moreover, with the rise of temperature in the last four decades, the upper limit of H. tibetana has shifted at least 30 m upward. Combining population history and recent range shift of this species is important in predicting the fate of this endemic species to future climate changes. PMID:24841004

Obstetrics and gynaecology chief resident attitudes toward teaching junior residents under normal working conditions.

PubMed

Gil, Karen M; Savitski, Jennifer L; Bazan, Sara; Patterson, Laurene R; Kirven, Melissa

2009-09-01

This study aimed to identify factors that chief residents believe impact the teaching of junior residents under normal working conditions and the areas in which they believe education on the role of resident as teacher would be beneficial. Obstetrics and gynaecology (O&G) chief residents were asked to rate the importance of teaching various skills, how often conflict situations arose, and to identify training that would be helpful through a national web-based survey. An e-mail was sent to coordinators of the Residency Review Committee (RRC) O&G residency programmes with a request that they forward the link to their chief residents three times from January through March 2006. Responses were received from 204 postgraduate Year 4 (PGY4) residents (18% of all PGY4 residents) from 133 programmes (54% of all residency programmes) and 33 states. Teaching junior residents how to prioritise patient care and obtain critical information in an emergent situation was considered very to extremely important by 97%. Conflict situations with junior residents were reported to occur between one and five times by 41-58%; an additional 26-28% reported that these situations occurred six or more times. Residents felt it would be helpful to extremely helpful to have training in resolving conflicts that involved patient care (48-59%), as well as in resolving conflict among junior residents, communicating effectively with them and becoming an effective leader (65-78%). The skills that chief residents considered most important to teach junior residents involved direct patient care. Chief residents would like training in how to resolve conflict with, and among, junior residents, and in how to become an effective leader.

Tolerance to high temperature extremes in an invasive lace bug, Corythucha ciliata (Hemiptera: Tingidae), in subtropical China.

PubMed

Ju, Rui-Ting; Gao, Lei; Zhou, Xu-Hui; Li, Bo

2013-01-01

Biological invasions are predicted to be more frequent as climate change is increasing its positive impact on the prevalence of invasive exotic species. Success of insect invaders in different temperature zones is closely related to their tolerance to temperature extremes. In this study, we used an exotic lace bug (Corythucha ciliata) as the study organism to address the hypotheses that an insect species invading a subtropical zone from temperate regions has a high capacity to survive and adapt to high temperatures, and that its thermal tolerance plays an important role in determining its seasonal abundance and geographic distribution. To test these hypotheses, the effects of heat shock on the survival and reproduction of C. ciliata adults were assessed in the laboratory. Adults were exposed to 26 (control), 35, 37, 39, 41, 43, and 45°C for 2 h, and then were transferred to 26°C. Heat-shock temperatures ranging from 35 to 41°C did not significantly affect survival pattern, longevity, and fecundity of adults, but heat shock at 43 and 45°C significantly reduced these traits. Exposing parent females to heat-shock treatments from 35 to 41°C did not significantly affect the hatching rate of their eggs, survival of the nymphs, and the proportion of female F(1) progeny, while no progeny were produced with treatments of 43 and 45°C. The results indicate that C. ciliata can tolerate high temperatures less than 41°C, which may contribute to its expansion into the lower latitudes in China where its hosts (Platanus trees) are widely planted. Our findings have important implications for predicting seasonal abundance and understanding invasion mechanisms of this important urban invader under climate change.

Crystal structures of native and xylosaccharide-bound alkali thermostable xylanase from an alkalophilic Bacillus sp. NG-27: Structural insights into alkalophilicity and implications for adaptation to polyextreme conditions

PubMed Central

Manikandan, Karuppasamy; Bhardwaj, Amit; Gupta, Naveen; Lokanath, Neratur K.; Ghosh, Amit; Reddy, Vanga Siva; Ramakumar, Suryanarayanarao

2006-01-01

Crystal structures are known for several glycosyl hydrolase family 10 (GH10) xylanases. However, none of them is from an alkalophilic organism that can grow in alkaline conditions. We have determined the crystal structures at 2.2 Å of a GH10 extracellular endoxylanase (BSX) from an alkalophilic Bacillus sp. NG-27, for the native and the complex enzyme with xylosaccharides. The industrially important enzyme is optimally active and stable at 343 K and at a pH of 8.4. Comparison of the structure of BSX with those of other thermostable GH10 xylanases optimally active at acidic or close to neutral pH showed that the solvent-exposed acidic amino acids, Asp and Glu, are markedly enhanced in BSX, while solvent-exposed Asn was noticeably depleted. The BSX crystal structure when compared with putative three-dimensional homology models of other extracellular alkalophilic GH10 xylanases from alkalophilic organisms suggests that a protein surface rich in acidic residues may be an important feature common to these alkali thermostable enzymes. A comparison of the surface features of BSX and of halophilic proteins allowed us to predict the activity of BSX at high salt concentrations, which we verified through experiments. This offered us important lessons in the polyextremophilicity of proteins, where understanding the structural features of a protein stable in one set of extreme conditions provided clues about the activity of the protein in other extreme conditions. The work brings to the fore the role of the nature and composition of solvent-exposed residues in the adaptation of enzymes to polyextreme conditions, as in BSX. PMID:16823036

Microbes in subglacial environments: Significant biogeochemical agents?

NASA Astrophysics Data System (ADS)

Lanoil, B.; Gaidos, E.; Anderson, S.

2003-04-01

Recent studies have demonstrated the presence of abundant microbes in several subglacial environments, including alpine and polar glaciers and the giant Antarctic subglacial lake, Lake Vostok. Some indirect isotopic and geochemical evidence indicate that microbial communities may be active in these cold, dark, extreme environments. We have been using molecular biology, microbiology, and geochemistry tools to correlate the identity of microbes in subglacial systems with important geochemical parameters. Our studies have focused on several sites, including a subglacial volcanic caldera lake in Iceland (Grímsvötn; GI), a temperate alpine valley glacier in Alaska (Bench Glacier; BG), and a polythermal Arctic valley glacier in Nunavut, Canada (John Evans Glacier; JEG). Our preliminary data indicate the presence of some similar microbial groups in BG and JEG, perhaps reflecting a selection for organisms which are capable of growth under extreme physical conditions. However, there is also a large fraction of the communities which differ between the Alaskan and Canadian sites. The predicted physiologies of the variable community components appear to correlate well with the geochemistry of the BG and JEG. We have also detected C-fixation and heterotrophic activities at near in situ conditions in intact samples and/or in bacteria isolated from all three sites. Furthermore, subglacial pelagic and sediment-attached microbial communities at GI are significantly different than snow or ice communities, indicating that the subglacial community may be endemic to the caldera lake. Based on these data, we predict that microbes play important roles in chemical weathering processes, organic carbon turnover, and other (bio)geochemical processes in subglacial environments. Our results may have important implications for biogeochemical cycles, especially during periods in earth history when there was significant ice cover, e.g. the Quaternary and Neoproterozoic “Snowball Earth” events and may provide insights into habitats on other planets.

Tolerance to High Temperature Extremes in an Invasive Lace Bug, Corythucha ciliata (Hemiptera: Tingidae), in Subtropical China

PubMed Central

Ju, Rui-Ting; Gao, Lei; Zhou, Xu-Hui; Li, Bo

2013-01-01

Biological invasions are predicted to be more frequent as climate change is increasing its positive impact on the prevalence of invasive exotic species. Success of insect invaders in different temperature zones is closely related to their tolerance to temperature extremes. In this study, we used an exotic lace bug (Corythucha ciliata) as the study organism to address the hypotheses that an insect species invading a subtropical zone from temperate regions has a high capacity to survive and adapt to high temperatures, and that its thermal tolerance plays an important role in determining its seasonal abundance and geographic distribution. To test these hypotheses, the effects of heat shock on the survival and reproduction of C. ciliata adults were assessed in the laboratory. Adults were exposed to 26 (control), 35, 37, 39, 41, 43, and 45°C for 2 h, and then were transferred to 26°C. Heat-shock temperatures ranging from 35 to 41°C did not significantly affect survival pattern, longevity, and fecundity of adults, but heat shock at 43 and 45°C significantly reduced these traits. Exposing parent females to heat-shock treatments from 35 to 41°C did not significantly affect the hatching rate of their eggs, survival of the nymphs, and the proportion of female F 1 progeny, while no progeny were produced with treatments of 43 and 45°C. The results indicate that C. ciliata can tolerate high temperatures less than 41°C, which may contribute to its expansion into the lower latitudes in China where its hosts (Platanus trees) are widely planted. Our findings have important implications for predicting seasonal abundance and understanding invasion mechanisms of this important urban invader under climate change. PMID:23365664

How do you think she feels? Vulnerability in empathy and the role of attention in school-aged children born extremely preterm.

PubMed

Campbell, Catherine; Horlin, Chiara; Reid, Corinne; McMichael, Judy; Forrest, Laura; Brydges, Chris; French, Noel; Anderson, Mike

2015-09-01

The aim of this study was to examine empathic competence in children born extremely preterm (EP, <28 weeks) given vulnerabilities in social relationships. Empathy in typically developing children is mediated by executive functions. Executive functioning is also impaired in preterm children. Of particular interest in this study are the attentional components of executive functioning as mediators of empathic development. Thirty-two 7-year-old EP children and 40 age-matched term children participated in the Project K.I.D.S program and completed the Kids Empathy Development Scale (KEDS), Wechsler Intelligence Scale for Children (WISC-IV), and Test of Everyday Attention for Children (TEA-Ch). Children born extremely preterm exhibited poorer performance on all measures. The mediating role of attention in empathy competence was not supported by mediation modelling when FSIQ was controlled. As predicted, the EP group showed weaker empathic development relative to typically developing children. They also showed poorer attentional abilities. However, the effect of preterm birth on empathy was not mediated by executive-level attention. The cognitive mechanisms underpinning poor empathy competence in EP children remain unclear. Future research needs to examine the role of inhibition, social-emotional recognition, and regulation. © 2015 The British Psychological Society.

Complicated Lower Extremity Wound Caused by Immune Thrombocytopenic Purpura Leading to Hypercoagulable State: A Team Approach for Limb Salvage

PubMed Central

Simman, Richard; Haluschak, John; Jackson, Sarah

2010-01-01

This article describes a complicated lower extremity wound due to hypercoagulable state caused by immune thrombocytopenic purpura. A team approach was important to limb salvage. A literature review is included. PMID:24527141

Familial correlates of social anxiety in children and adolescents.

PubMed

Bögels, S M; van Oosten, A; Muris, P; Smulders, D

2001-03-01

Retrospective studies suggest a relationship between parental rearing practices and social phobia. The present study investigated whether socially anxious children perceive their current parental rearing as rejecting, overprotective, and lacking emotional warmth, and as emphasizing the importance of other's opinion, and de-emphasizing social initiatives and family sociability. Furthermore, we examined whether parents of socially anxious children report to rely on such rearing practices, and suffer themselves from social fears. A regression analysis as well as extreme group comparisons were applied. Little support was found for the presumed role of the assessed family rearing aspects in the development of social anxiety in children. Solely family sociability (children's and mothers' report) and children's perception of overprotection of the mother predicted social anxiety in the regression analysis. Given the influence of the mentioned rearing practices, social anxiety of the mother still significantly predicted social anxiety of the child. In the extreme group comparisons, differences in the expected direction were found between socially anxious and normal children on parental rejection, emotional warmth, and family sociability. However, the lack of differences between socially anxious and clinical control children suggests that these variables do not form a specific pathway to social fears.

The future of genomics in polar and alpine cyanobacteria

PubMed Central

Anesio, Alexandre M; Sánchez-Baracaldo, Patricia

2018-01-01

Abstract In recent years, genomic analyses have arisen as an exciting way of investigating the functional capacity and environmental adaptations of numerous micro-organisms of global relevance, including cyanobacteria. In the extreme cold of Arctic, Antarctic and alpine environments, cyanobacteria are of fundamental ecological importance as primary producers and ecosystem engineers. While their role in biogeochemical cycles is well appreciated, little is known about the genomic makeup of polar and alpine cyanobacteria. In this article, we present ways that genomic techniques might be used to further our understanding of cyanobacteria in cold environments in terms of their evolution and ecology. Existing examples from other environments (e.g. marine/hot springs) are used to discuss how methods developed there might be used to investigate specific questions in the cryosphere. Phylogenomics, comparative genomics and population genomics are identified as methods for understanding the evolution and biogeography of polar and alpine cyanobacteria. Transcriptomics will allow us to investigate gene expression under extreme environmental conditions, and metagenomics can be used to complement tradition amplicon-based methods of community profiling. Finally, new techniques such as single cell genomics and metagenome assembled genomes will also help to expand our understanding of polar and alpine cyanobacteria that cannot readily be cultured. PMID:29506259

Contrasting behavior of covalent and molecular carbon allotropes exposed to extreme ultraviolet and soft x-ray free-electron laser radiation

NASA Astrophysics Data System (ADS)

Toufarová, M.; Hájková, V.; Chalupský, J.; Burian, T.; Vacík, J.; Vorlíček, V.; Vyšín, L.; Gaudin, J.; Medvedev, N.; Ziaja, B.; Nagasono, M.; Yabashi, M.; Sobierajski, R.; Krzywinski, J.; Sinn, H.; Störmer, M.; Koláček, K.; Tiedtke, K.; Toleikis, S.; Juha, L.

2017-12-01

All carbon materials, e.g., amorphous carbon (a-C) coatings and C60 fullerene thin films, play an important role in short-wavelength free-electron laser (FEL) research motivated by FEL optics development and prospective nanotechnology applications. Responses of a-C and C60 layers to the extreme ultraviolet (SPring-8 Compact SASE Source in Japan) and soft x-ray (free-electron laser in Hamburg) free-electron laser radiation are investigated by Raman spectroscopy, differential interference contrast, and atomic force microscopy. A remarkable difference in the behavior of covalent (a-C) and molecular (C60) carbonaceous solids is demonstrated under these irradiation conditions. Low thresholds for ablation of a fullerene crystal (estimated to be around 0.15 eV/atom for C60 vs 0.9 eV/atom for a-C in terms of the absorbed dose) are caused by a low cohesive energy of fullerene crystals. An efficient mechanism of the removal of intact C60 molecules from the irradiated crystal due to Coulomb repulsion of fullerene-cage cation radicals formed by the ionizing radiation is revealed by a detailed modeling.

Contrasting behavior of covalent and molecular carbon allotropes exposed to extreme ultraviolet and soft x-ray free-electron laser radiation

DOE PAGES

Toufarová, M.; Hájková, V.; Chalupský, J.; ...

2017-12-04

All carbon materials, e.g., amorphous carbon (a-C) coatings and C 60 fullerene thin films, play an important role in short-wavelength free-electron laser (FEL) research motivated by FEL optics development and prospective nanotechnology applications. We investigate responses of a-C and C 60 layers to the extreme ultraviolet (SPring-8 Compact SASE Source in Japan) and soft x-ray (free-electron laser in Hamburg) free-electron laser radiation by Raman spectroscopy, differential interference contrast, and atomic force microscopy. A remarkable difference in the behavior of covalent (a-C) and molecular ( C 60 ) carbonaceous solids is demonstrated under these irradiation conditions. Low thresholds for ablation ofmore » a fullerene crystal (estimated to be around 0.15 eV/atom for C 60 vs 0.9 eV/atom for a-C in terms of the absorbed dose) are caused by a low cohesive energy of fullerene crystals. An efficient mechanism of the removal of intact C 60 molecules from the irradiated crystal due to Coulomb repulsion of fullerene-cage cation radicals formed by the ionizing radiation is revealed by a detailed modeling.« less

Protein Sequence Classification with Improved Extreme Learning Machine Algorithms

PubMed Central

2014-01-01

Precisely classifying a protein sequence from a large biological protein sequences database plays an important role for developing competitive pharmacological products. Comparing the unseen sequence with all the identified protein sequences and returning the category index with the highest similarity scored protein, conventional methods are usually time-consuming. Therefore, it is urgent and necessary to build an efficient protein sequence classification system. In this paper, we study the performance of protein sequence classification using SLFNs. The recent efficient extreme learning machine (ELM) and its invariants are utilized as the training algorithms. The optimal pruned ELM is first employed for protein sequence classification in this paper. To further enhance the performance, the ensemble based SLFNs structure is constructed where multiple SLFNs with the same number of hidden nodes and the same activation function are used as ensembles. For each ensemble, the same training algorithm is adopted. The final category index is derived using the majority voting method. Two approaches, namely, the basic ELM and the OP-ELM, are adopted for the ensemble based SLFNs. The performance is analyzed and compared with several existing methods using datasets obtained from the Protein Information Resource center. The experimental results show the priority of the proposed algorithms. PMID:24795876

Oxygen Profile of a Thermo-Haliophilic Community in the Badwater Salt Flat

NASA Technical Reports Server (NTRS)

Smith, H. D.; McKay, C. P.; Rainey, F.; Bebout, B.; Carpenter, S.

2004-01-01

Badwater is the lowest, saltiest, and hottest, place in North America. This extreme environment is 86 meters (282 feet) below sea level surrounded by four mountain ranges. Due to the geographical location Badwater does not receive moisture from the prevailing winds, this intern results in a hot, arid, and salty environment. Despite these extreme living conditions, microbes manage to flourish within the salt flat. The salt acts as an insulator making life just beneath the surface more comfortable In this paper, we compare the microbial population versus oxygen concentration; and the importance of and the role of oxygen in metabolic functions by these thermo-haliophiles. Furthermore a model of the oxygen profile will also provide an insight to the oxygen cycle in salty environments. This research has implications for the limits of life on Earth and Mars. Recent results from the MER rovers show that water on Mars was very salty. Measuring the oxygen profile in these salty environments on Earth provides a framework within which potential life on Mars can be evaluated. The use of an oxygen profile could also be used as a search criteria for life.

Contrasting behavior of covalent and molecular carbon allotropes exposed to extreme ultraviolet and soft x-ray free-electron laser radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toufarová, M.; Hájková, V.; Chalupský, J.

All carbon materials, e.g., amorphous carbon (a-C) coatings and C 60 fullerene thin films, play an important role in short-wavelength free-electron laser (FEL) research motivated by FEL optics development and prospective nanotechnology applications. We investigate responses of a-C and C 60 layers to the extreme ultraviolet (SPring-8 Compact SASE Source in Japan) and soft x-ray (free-electron laser in Hamburg) free-electron laser radiation by Raman spectroscopy, differential interference contrast, and atomic force microscopy. A remarkable difference in the behavior of covalent (a-C) and molecular ( C 60 ) carbonaceous solids is demonstrated under these irradiation conditions. Low thresholds for ablation ofmore » a fullerene crystal (estimated to be around 0.15 eV/atom for C 60 vs 0.9 eV/atom for a-C in terms of the absorbed dose) are caused by a low cohesive energy of fullerene crystals. An efficient mechanism of the removal of intact C 60 molecules from the irradiated crystal due to Coulomb repulsion of fullerene-cage cation radicals formed by the ionizing radiation is revealed by a detailed modeling.« less

Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer.

PubMed

Yamasaki, Akio; Nakayama, Kazunori; Imaizumi, Akira; Kawamoto, Makoto; Fujimura, Akiko; Oyama, Yasuhiro; Nagai, Shuntaro; Yanai, Kosuke; Onishi, Hideya

2017-12-01

In pancreatic cancer, where the microenvironment is extremely hypoxic, analyzing signal transduction under hypoxia is thought to be significantly important. By investigating microarray analysis of pancreatic cancer cells cultured under both normoxia and hypoxia, we found that the expression of leukocyte common antigen-related (LAR)-interacting protein (liprin)-α4 was extremely increased under hypoxia compared to under normoxia. In the present study, the biological significance of liprin-α4 in pancreatic cancer was investigated and whether liprin-α4 has potential as a therapeutic target for pancreatic cancer was estimated. Suppression of liprin-α4 reduced proliferation of pancreatic cancer cells both in vitro and in vivo. Inhibition of liprin-α4 also reduced invasiveness through the suppression of endothelial-mesenchymal transition. Stimulation by liprin-α4 was through phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways. Liprin-α4 plays a pivotal role in inducing malignant phenotypes such as increased proliferation and invasion in pancreatic cancer, and that liprin-α4 could be a new effective therapeutic target for pancreatic cancer. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Secrets of virtuoso: neuromuscular attributes of motor virtuosity in expert musicians

PubMed Central

Furuya, Shinichi; Oku, Takanori; Miyazaki, Fumio; Kinoshita, Hiroshi

2015-01-01

Musical performance requires extremely fast and dexterous limb movements. The underlying biological mechanisms have been an object of interest among scientists and non-scientists for centuries. Numerous studies of musicians and non-musicians have demonstrated that neuroplastic adaptations through early and deliberate musical training endowed superior motor skill. However, little has been unveiled about what makes inter-individual differences in motor skills among musicians. Here we determined the attributes of inter-individual differences in the maximum rate of repetitive piano keystrokes in twenty-four pianists. Among various representative factors of neuromuscular functions, anatomical characteristics, and training history, a stepwise multiple regression analysis and generalized linear model identified two predominant predictors of the maximum rate of repetitive piano keystrokes; finger tapping rate and muscular strength of the elbow extensor. These results suggest a non-uniform role of individual limb muscles in the production of extremely fast repetitive multi-joint movements. Neither age of musical training initiation nor the amount of extensive musical training before age twenty was a predictor. Power grip strength was negatively related to the maximum rate of piano keystrokes only during the smallest tone production. These findings highlight the importance of innate biological nature and explicit training for motor virtuosity. PMID:26502770

Response styles, bipolar risk, and mood in students: The Behaviours Checklist.

PubMed

Fisk, Claire; Dodd, Alyson L; Collins, Alan

2015-12-01

An Integrative Cognitive Model of mood swings and bipolar disorder proposes that extreme positive and negative appraisals about internal states trigger ascent and descent behaviours, contributing to the onset and maintenance of mood swings. This study investigated the reliability and validity of a new inventory, the Behaviours Checklist (BC), by measuring associations with appraisals, response styles to positive and negative affect, bipolar risk, mania, and depression. Correlational analogue study. Students (N = 134) completed the BC alongside measures of appraisals, response styles to positive and negative mood, mania, depression, and hypomanic personality (bipolar risk). The BC was of adequate reliability and showed good validity. Ascent behaviours and appraisals predicted bipolar risk, whereas descent behaviours and appraisals were associated with depression. Appraisals, ascent, and descent behaviours may play an important role in the development and maintenance of mood swings. Limitations and research recommendations are outlined. Extreme positive and negative appraisals of internal states, and subsequent behavioural responses (ascent and descent behaviours), are associated with bipolar risk and bipolar mood symptoms in a student sample. These processes are involved with mood dysregulation in clinical populations as well as bipolar risk in students, with implications for mood management. © 2015 The British Psychological Society.