Neuropsychology of prefrontal cortex

PubMed Central

Siddiqui, Shazia Veqar; Chatterjee, Ushri; Kumar, Devvarta; Siddiqui, Aleem; Goyal, Nishant

2008-01-01

The history of clinical frontal lobe study is long and rich which provides valuable insights into neuropsychologic determinants of functions of prefrontal cortex (PFC). PFC is often classified as multimodal association cortex as extremely processed information from various sensory modalities is integrated here in a precise fashion to form the physiologic constructs of memory, perception, and diverse cognitive processes. Human neuropsychologic studies also support the notion of different functional operations within the PFC. The specification of the component ‘executive’ processes and their localization to particular regions of PFC have been implicated in a wide variety of psychiatric disorders. PMID:19742233

Interferometric atmospheric refractive-index environmental monitor

NASA Astrophysics Data System (ADS)

Ludman, Jacques E.; Ludman, Jacques J.; Callahan, Heidi; Robinson, John; Davis, Seth; Caulfield, H. John; Watt, David; Sampson, John L.; Hunt, Arlon

1995-06-01

Long, open-path, outdoor interferometric measurement of the index of refraction as a function of wavelength (spectral refractivity) requires a number of innovations. These include active compensation for vibration and turbulence. The use of electronic compensation produces an electronic signal that is ideal for extracting data. This allows the appropriate interpretation of those data and the systematic and fast scanning of the spectrum by the use of bandwidths that are intermediate between lasers (narrow bandwidth) and white light (broad bandwidth). An Environmental Interferometer that incorporates these features should be extremely valuable in both pollutant detection and pollutant identification. Spectral refractivity measurements complement the information available

European national healthy city networks: the impact of an elite epistemic community.

PubMed

Heritage, Zoë; Green, Geoff

2013-10-01

National healthy cities networks (NNs) were created 20 years ago to support the development of healthy cities within the WHO Europe Region. Using the concept of epistemic communities, the evolution and impact of NNs is considered, as is their future development. Healthy cities national networks are providing information, training and support to member cities. In many cases, they are also involved in supporting national public health policy development and disseminating out healthy city principles to other local authorities. National networks are a fragile but an extremely valuable resource for sharing public health knowledge.

Decision strategies for handling the uncertainty of future extreme rainfall under the influence of climate change.

PubMed

Gregersen, I B; Arnbjerg-Nielsen, K

2012-01-01

Several extraordinary rainfall events have occurred in Denmark within the last few years. For each event, problems in urban areas occurred as the capacity of the existing drainage systems were exceeded. Adaptation to climate change is necessary but also very challenging as urban drainage systems are characterized by long technical lifetimes and high, unrecoverable construction costs. One of the most important barriers for the initiation and implementation of the adaptation strategies is therefore the uncertainty when predicting the magnitude of the extreme rainfall in the future. This challenge is explored through the application and discussion of three different theoretical decision support strategies: the precautionary principle, the minimax strategy and Bayesian decision support. The reviewed decision support strategies all proved valuable for addressing the identified uncertainties, at best applied together as they all yield information that improved decision making and thus enabled more robust decisions.

Scene text detection by leveraging multi-channel information and local context

NASA Astrophysics Data System (ADS)

Wang, Runmin; Qian, Shengyou; Yang, Jianfeng; Gao, Changxin

2018-03-01

As an important information carrier, texts play significant roles in many applications. However, text detection in unconstrained scenes is a challenging problem due to cluttered backgrounds, various appearances, uneven illumination, etc.. In this paper, an approach based on multi-channel information and local context is proposed to detect texts in natural scenes. According to character candidate detection plays a vital role in text detection system, Maximally Stable Extremal Regions(MSERs) and Graph-cut based method are integrated to obtain the character candidates by leveraging the multi-channel image information. A cascaded false positive elimination mechanism are constructed from the perspective of the character and the text line respectively. Since the local context information is very valuable for us, these information is utilized to retrieve the missing characters for boosting the text detection performance. Experimental results on two benchmark datasets, i.e., the ICDAR 2011 dataset and the ICDAR 2013 dataset, demonstrate that the proposed method have achieved the state-of-the-art performance.

Flood frequency estimates and documented and potential extreme peak discharges in Oklahoma

USGS Publications Warehouse

Tortorelli, Robert L.; McCabe, Lan P.

2001-01-01

Knowledge of the magnitude and frequency of floods is required for the safe and economical design of highway bridges, culverts, dams, levees, and other structures on or near streams; and for flood plain management programs. Flood frequency estimates for gaged streamflow sites were updated, documented extreme peak discharges for gaged and miscellaneous measurement sites were tabulated, and potential extreme peak discharges for Oklahoma streamflow sites were estimated. Potential extreme peak discharges, derived from the relation between documented extreme peak discharges and contributing drainage areas, can provide valuable information concerning the maximum peak discharge that could be expected at a stream site. Potential extreme peak discharge is useful in conjunction with flood frequency analysis to give the best evaluation of flood risk at a site. Peak discharge and flood frequency for selected recurrence intervals from 2 to 500 years were estimated for 352 gaged streamflow sites. Data through 1999 water year were used from streamflow-gaging stations with at least 8 years of record within Oklahoma or about 25 kilometers into the bordering states of Arkansas, Kansas, Missouri, New Mexico, and Texas. These sites were in unregulated basins, and basins affected by regulation, urbanization, and irrigation. Documented extreme peak discharges and associated data were compiled for 514 sites in and near Oklahoma, 352 with streamflow-gaging stations and 162 at miscellaneous measurements sites or streamflow-gaging stations with short record, with a total of 671 measurements.The sites are fairly well distributed statewide, however many streams, large and small, have never been monitored. Potential extreme peak-discharge curves were developed for streamflow sites in hydrologic regions of the state based on documented extreme peak discharges and the contributing drainage areas. Two hydrologic regions, east and west, were defined using 98 degrees 15 minutes longitude as the dividing line.

Using subseasonal-to-seasonal (S2S) extreme rainfall forecasts for extended-range flood prediction in Australia

NASA Astrophysics Data System (ADS)

White, C. J.; Franks, S. W.; McEvoy, D.

2015-06-01

Meteorological and hydrological centres around the world are looking at ways to improve their capacity to be able to produce and deliver skilful and reliable forecasts of high-impact extreme rainfall and flooding events on a range of prediction timescales (e.g. sub-daily, daily, multi-week, seasonal). Making improvements to extended-range rainfall and flood forecast models, assessing forecast skill and uncertainty, and exploring how to apply flood forecasts and communicate their benefits to decision-makers are significant challenges facing the forecasting and water resources management communities. This paper presents some of the latest science and initiatives from Australia on the development, application and communication of extreme rainfall and flood forecasts on the extended-range "subseasonal-to-seasonal" (S2S) forecasting timescale, with a focus on risk-based decision-making, increasing flood risk awareness and preparedness, capturing uncertainty, understanding human responses to flood forecasts and warnings, and the growing adoption of "climate services". The paper also demonstrates how forecasts of flood events across a range of prediction timescales could be beneficial to a range of sectors and society, most notably for disaster risk reduction (DRR) activities, emergency management and response, and strengthening community resilience. Extended-range S2S extreme flood forecasts, if presented as easily accessible, timely and relevant information are a valuable resource to help society better prepare for, and subsequently cope with, extreme flood events.

Methane clumped isotopes: Progress and potential for a new isotopic tracer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Douglas, Peter M. J.; Stolper, Daniel A.; Eiler, John M.

The isotopic composition of methane is of longstanding geochemical interest, with important implications for understanding hydrocarbon systems, atmospheric greenhouse gas concentrations, the global carbon cycle, and life in extreme environments. Recent analytical developments focusing on multiply substituted isotopologues (‘clumped isotopes’) are opening a potentially valuable new window into methane geochemistry. When methane forms in internal isotopic equilibrium, clumped isotopes can provide a direct record of formation temperature, making this property particularly valuable for identifying different methane origins. However, it has also become clear that in certain settings methane clumped isotope measurements record kinetic rather than equilibrium isotope effects. Here wemore » present a substantially expanded dataset of methane clumped isotope analyses, and provide a synthesis of the current interpretive framework for this parameter. We review different processes affecting methane clumped isotope compositions, describe the relationships between conventional isotope and clumped isotope data, and summarize the types of information that this measurement can provide in different Earth and planetary environments.« less

The Heat Exposure Integrated Deprivation Index (HEIDI): A data-driven approach to quantifying neighborhood risk during extreme hot weather.

PubMed

Krstic, Nikolas; Yuchi, Weiran; Ho, Hung Chak; Walker, Blake B; Knudby, Anders J; Henderson, Sarah B

2017-12-01

Mortality attributable to extreme hot weather is a growing concern in many urban environments, and spatial heat vulnerability indexes are often used to identify areas at relatively higher and lower risk. Three indexes were developed for greater Vancouver, Canada using a pool of 20 potentially predictive variables categorized to reflect social vulnerability, population density, temperature exposure, and urban form. One variable was chosen from each category: an existing deprivation index, senior population density, apparent temperature, and road density, respectively. The three indexes were constructed from these variables using (1) unweighted, (2) weighted, and (3) data-driven Heat Exposure Integrated Deprivation Index (HEIDI) approaches. The performance of each index was assessed using mortality data from 1998-2014, and the maps were compared with respect to spatial patterns identified. The population-weighted spatial correlation between the three indexes ranged from 0.68-0.89. The HEIDI approach produced a graduated map of vulnerability, whereas the other approaches primarily identified areas of highest risk. All indexes performed best under extreme temperatures, but HEIDI was more useful at lower thresholds. Each of the indexes in isolation provides valuable information for public health protection, but combining the HEIDI approach with unweighted and weighted methods provides richer information about areas most vulnerable to heat. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Remote sensing: Snow monitoring tool for today and tomorrow

NASA Technical Reports Server (NTRS)

Rango, A.

1977-01-01

Various types of remote sensing are now available or will be in the future for snowpack monitoring. Aircraft reconnaissance is now used in a conventional manner by various water resources agencies to obtain information on snowlines, depth, and melting of the snowpack for forecasting purposes. The use of earth resources satellites for mapping snowcovered area, snowlines, and changes in snowcover during the spring has increased during the last five years. Gamma ray aircraft flights, although confined to an extremely low altitude, provide a means for obtaining valuable information on snow water equivalent. The most recently developed remote sensing technology for snow, namely, microwave monitoring, has provided initial results that may eventually allow us to infer snow water equivalent or depth, snow wetness, and the hydrologic condition of the underlying soil.

Active and Progressive Exoskeleton Rehabilitation Using Multisource Information Fusion From EMG and Force-Position EPP.

PubMed

Fan, Yuanjie; Yin, Yuehong

2013-12-01

Although exoskeletons have received enormous attention and have been widely used in gait training and walking assistance in recent years, few reports addressed their application during early poststroke rehabilitation. This paper presents a healthcare technology for active and progressive early rehabilitation using multisource information fusion from surface electromyography and force-position extended physiological proprioception. The active-compliance control based on interaction force between patient and exoskeleton is applied to accelerate the recovery of the neuromuscular function, whereby progressive treatment through timely evaluation contributes to an effective and appropriate physical rehabilitation. Moreover, a clinic-oriented rehabilitation system, wherein a lower extremity exoskeleton with active compliance is mounted on a standing bed, is designed to ensure comfortable and secure rehabilitation according to the structure and control requirements. Preliminary experiments and clinical trial demonstrate valuable information on the feasibility, safety, and effectiveness of the progressive exoskeleton-assisted training.

Global surface temperatures and the atmospheric electrical circuit

NASA Technical Reports Server (NTRS)

Price, Colin

1993-01-01

To monitor future global temperature trends, it would be extremely useful if parameters nonlinearly related to surface temperature could be found, thereby amplifying any warming signal that may exist. Evidence that global thunderstorm activity is nonlinearly related to diurnal, seasonal and interannual temperature variations is presented. Since global thunderstorm activity is also well correlated with the earth's ionospheric potential, it appears that variations of ionospheric potential, that can be measured at a single location, may be able to supply valuable information regarding global surface temperature fluctuations. The observations presented enable a prediction that a 1 percent increase in global surface temperatures may result in a 20 percent increase in ionospheric potential.

Magnetic resonance imaging of the pediatric neck: an overview.

PubMed

Shekdar, Karuna V; Mirsky, David M; Kazahaya, Ken; Bilaniuk, Larissa T

2012-08-01

Evaluation of neck lesions in the pediatric population can be a diagnostic challenge, for which magnetic resonance (MR) imaging is extremely valuable. This article provides an overview of the value and utility of MR imaging in the evaluation of pediatric neck lesions, addressing what the referring clinician requires from the radiologist. Concise descriptions and illustrations of MR imaging findings of commonly encountered pathologic entities in the pediatric neck, including abnormalities of the branchial apparatus, thyroglossal duct anomalies, and neoplastic processes, are given. An approach to establishing a differential diagnosis is provided, and critical points of information are summarized. Copyright © 2012 Elsevier Inc. All rights reserved.

Community detection in complex networks using deep auto-encoded extreme learning machine

NASA Astrophysics Data System (ADS)

Wang, Feifan; Zhang, Baihai; Chai, Senchun; Xia, Yuanqing

2018-06-01

Community detection has long been a fascinating topic in complex networks since the community structure usually unveils valuable information of interest. The prevalence and evolution of deep learning and neural networks have been pushing forward the advancement in various research fields and also provide us numerous useful and off the shelf techniques. In this paper, we put the cascaded stacked autoencoders and the unsupervised extreme learning machine (ELM) together in a two-level embedding process and propose a novel community detection algorithm. Extensive comparison experiments in circumstances of both synthetic and real-world networks manifest the advantages of the proposed algorithm. On one hand, it outperforms the k-means clustering in terms of the accuracy and stability thus benefiting from the determinate dimensions of the ELM block and the integration of sparsity restrictions. On the other hand, it endures smaller complexity than the spectral clustering method on account of the shrinkage in time spent on the eigenvalue decomposition procedure.

Current Advances on the Structure, Bioactivity, Synthesis, and Metabolic Regulation of Novel Ubiquinone Derivatives in the Edible and Medicinal Mushroom Antrodia cinnamomea.

PubMed

Zhang, Bo-Bo; Hu, Peng-Fei; Huang, Jing; Hu, Yong-Dan; Chen, Lei; Xu, Gan-Rong

2017-12-06

In recent years, Antrodia cinnamomea has attracted great attention around the world as an extremely precious edible and medicinal mushroom. Ubiquinone derivatives, which are characteristic metabolites of A. cinnamomea, have shown great bioactivities. Some of them have been regarded as promising therapeutic agents and approved into clinical trial by the U.S. Food and Drug Administration. Although some excellent reviews have been published covering different aspects of A. cinnamomea, this review brings, for the first time, complete information about the structure, bioactivity, chemical synthesis, biosynthesis, and metabolic regulation of ubiquinone derivatives in A. cinnamomea. It not only advances our knowledge on the bioactive metabolites, especially the ubiquinone derivatives, in A. cinnamomea but also provides valuable information for the investigation on other edible and medicinal mushrooms.

Adjoint-Based Algorithms for Adaptation and Design Optimizations on Unstructured Grids

NASA Technical Reports Server (NTRS)

Nielsen, Eric J.

2006-01-01

Schemes based on discrete adjoint algorithms present several exciting opportunities for significantly advancing the current state of the art in computational fluid dynamics. Such methods provide an extremely efficient means for obtaining discretely consistent sensitivity information for hundreds of design variables, opening the door to rigorous, automated design optimization of complex aerospace configuration using the Navier-Stokes equation. Moreover, the discrete adjoint formulation provides a mathematically rigorous foundation for mesh adaptation and systematic reduction of spatial discretization error. Error estimates are also an inherent by-product of an adjoint-based approach, valuable information that is virtually non-existent in today's large-scale CFD simulations. An overview of the adjoint-based algorithm work at NASA Langley Research Center is presented, with examples demonstrating the potential impact on complex computational problems related to design optimization as well as mesh adaptation.

Balloon concepts for scientific investigation of Mars and Jupiter

NASA Technical Reports Server (NTRS)

Ash, R. L.

1979-01-01

Opportunities for scientific investigation of the atmospheric planets using buoyant balloons have been explored. Mars and Jupiter were considered in this study because design requirements at those planets bracket nominally the requirements at Venus, and plans are already underway for a joint Russian-French balloon system at Venus. Viking data has provided quantitative information for definition of specific balloon systems at Mars. Free flying balloons appear capable of providing valuable scientific support for more sophisticated Martian surface probes, but tethered and powered aerostats are not attractive. The Jovian environment is so extreme, hot atmosphere balloons may be the only scientific platforms capable of extended operations there. However, the estimated system mass and thermal energy required are very large.

How virtue ethics informs medical professionalism.

PubMed

McCammon, Susan D; Brody, Howard

2012-12-01

We argue that a turn toward virtue ethics as a way of understanding medical professionalism represents both a valuable corrective and a missed opportunity. We look at three ways in which a closer appeal to virtue ethics could help address current problems or issues in professionalism education-first, balancing professionalism training with demands for professional virtues as a prerequisite; second, preventing demands for the demonstrable achievement of competencies from working against ideal professionalism education as lifelong learning; and third, avoiding temptations to dismiss moral distress as a mere "hidden curriculum" problem. As a further demonstration of how best to approach a lifelong practice of medical virtue, we will examine altruism as a mean between the extremes of self-sacrifice and selfishness.

Monitoring volatilization products using Residual Gas Analyzers during MeV ion beam irradiations

NASA Astrophysics Data System (ADS)

Wetteland, C. J.; Kriewaldt, K.; Taylor, L. A.; McSween, H. Y.; Sickafus, K. E.

2018-03-01

The use of Residual Gas Analyzers (RGAs) during irradiation experiments can provide valuable information when incorporated into experimental end-stations. The instruments can track the volatilization products of beam-sensitive materials, which may ultimately aid researchers in selecting appropriate flux values for conducting experiments. Furthermore, the type of gaseous species released during an irradiation can be monitored directly, which may lead to new insights into the radiolysis and/or heating mechanisms responsible for gas evolution. A survey of several classes of materials exposed to extremes in particle flux is presented to show how RGA instrumentation can be incorporated to qualitatively assess ion-solid interactions in a variety of fields.

An application programming interface for extreme precipitation and hazard products

NASA Astrophysics Data System (ADS)

Kirschbaum, D.; Stanley, T.; Cappelaere, P. G.; Reed, J.; Lammers, M.

2016-12-01

Remote sensing data provides situational awareness of extreme events and hazards over large areas in a way that is impossible to achieve with in situ data. However, more valuable than raw data is actionable information based on user needs. This information can take the form of derived products, extraction of a subset of variables in a larger data matrix, or data processing for a specific goal. These products can then stream to the end users, who can use these data to improve local to global decision making. This presentation will outline both the science and methodology of two new data products and tools that can provide relevant climate and hazard data for response and support. The Global Precipitation Measurement (GPM) mission provides near real-time information on rain and snow around the world every thirty minutes. Through a new applications programing interface (API), this data can be freely accessed by consumers to visualize, analyze, and communicate where, when and how much rain is falling worldwide. The second tool is a global landslide model that provides situational awareness of potential landslide activity in near real-time, utilizing several remotely sensed data products. This hazard information is also provided through an API and is being ingested by the emergency response community, international aid organizations, and others around the world. This presentation will highlight lessons learned through the development, implementation, and communication of these products and tools with the goal of enabling better and more effective decision making.

Introduction of a Novel Loss Data Normalization Method for Improved Estimation of Extreme Losses from Natural Catastrophes

NASA Astrophysics Data System (ADS)

Eichner, J. F.; Steuer, M.; Loew, P.

2016-12-01

Past natural catastrophes offer valuable information for present-day risk assessment. To make use of historic loss data one has to find a setting that enables comparison (over place and time) of historic events happening under today's conditions. By means of loss data normalization the influence of socio-economic development, as the fundamental driver in this context, can be eliminated and the data gives way to the deduction of risk-relevant information and allows the study of other driving factors such as influences from climate variability and climate change or changes of vulnerability. Munich Re's NatCatSERVICE database includes for each historic loss event the geographic coordinates of all locations and regions that were affected in a relevant way. These locations form the basis for what is known as the loss footprint of an event. Here we introduce a state of the art and robust method for global loss data normalization. The presented peril-specific loss footprint normalization method adjusts direct economic loss data to the influence of economic growth within each loss footprint (by using gross cell product data as proxy for local economic growth) and makes loss data comparable over time. To achieve a comparative setting for supra-regional economic differences, we categorize the normalized loss values (together with information on fatalities) based on the World Bank income groups into five catastrophe classes, from minor to catastrophic. The data treated in such way allows (a) for studying the influence of improved reporting of small scale loss events over time and (b) for application of standard (stationary) extreme value statistics (here: peaks over threshold method) to compile estimates for extreme and extrapolated loss magnitudes such as a "100 year event" on global scale. Examples of such results will be shown.

Bayes Factors Unmask Highly Variable Information Content, Bias, and Extreme Influence in Phylogenomic Analyses.

PubMed

Brown, Jeremy M; Thomson, Robert C

2017-07-01

As the application of genomic data in phylogenetics has become routine, a number of cases have arisen where alternative data sets strongly support conflicting conclusions. This sensitivity to analytical decisions has prevented firm resolution of some of the most recalcitrant nodes in the tree of life. To better understand the causes and nature of this sensitivity, we analyzed several phylogenomic data sets using an alternative measure of topological support (the Bayes factor) that both demonstrates and averts several limitations of more frequently employed support measures (such as Markov chain Monte Carlo estimates of posterior probabilities). Bayes factors reveal important, previously hidden, differences across six "phylogenomic" data sets collected to resolve the phylogenetic placement of turtles within Amniota. These data sets vary substantially in their support for well-established amniote relationships, particularly in the proportion of genes that contain extreme amounts of information as well as the proportion that strongly reject these uncontroversial relationships. All six data sets contain little information to resolve the phylogenetic placement of turtles relative to other amniotes. Bayes factors also reveal that a very small number of extremely influential genes (less than 1% of genes in a data set) can fundamentally change significant phylogenetic conclusions. In one example, these genes are shown to contain previously unrecognized paralogs. This study demonstrates both that the resolution of difficult phylogenomic problems remains sensitive to seemingly minor analysis details and that Bayes factors are a valuable tool for identifying and solving these challenges. © The Author(s) 2016. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Examining global extreme sea level variations on the coast from in-situ and remote observations

NASA Astrophysics Data System (ADS)

Menendez, Melisa; Benkler, Anna S.

2017-04-01

The estimation of extreme water level values on the coast is a requirement for a wide range of engineering and coastal management applications. In addition, climate variations of extreme sea levels on the coastal area result from a complex interacting of oceanic, atmospheric and terrestrial processes across a wide range of spatial and temporal scales. In this study, variations of extreme sea level return values are investigated from two available sources of information: in-situ tide-gauge records and satellite altimetry data. Long time series of sea level from tide-gauge records are the most valuable observations since they directly measure water level in a specific coastal location. They have however a number of sources of in-homogeneities that may affect the climate description of extremes when this data source is used. Among others, the presence of gaps, historical time in-homogeneities and jumps in the mean sea level signal are factors that can provide uncertainty in the characterization of the extreme sea level behaviour. Moreover, long records from tide-gauges are sparse and there are many coastal areas worldwide without in-situ available information. On the other hand, with the accumulating altimeter records of several satellite missions from the 1990s, approaching 25 recorded years at the time of writing, it is becoming possible the analysis of extreme sea level events from this data source. Aside the well-known issue of altimeter measurements very close to the coast (mainly due to corruption by land, wet troposphere path delay errors and local tide effects on the coastal area), there are other aspects that have to be considered when sea surface height values estimated from satellite are going to be used in a statistical extreme model, such as the use of a multi-mission product to get long observed periods and the selection of the maxima sample, since altimeter observations do not provide values uniform in time and space. Here, we have compared the extreme values of 'still water level' and 'non-tidal-residual' of in-situ records from the GESLA2 dataset (Woodworth et al. 2016) against the novel coastal altimetry datasets (Cipollini et al. 2016). Seasonal patterns, inter-annual variability and long-term trends are analyzed. Then, a time-dependent extreme model (Menendez et al. 2009) is applied to characterize extreme sea level return values and their variability on the coastal area around the world.

IR imaging of blood circulation of patients with vascular disease

NASA Astrophysics Data System (ADS)

Wang, Hsin; Wade, Dwight R., Jr.; Kam, Jack

2004-04-01

We conducted a preliminary IR imaging study of blood circulation in patients with peripheral vascular diseases. Abnormal blood flow is common in older adults, especially those with elevated blood lipids, diabetes, hypertension, and a history of smoking. All of these conditions have a high prevalence in our population, often with more than one condition in the same individual. The differences in blood flow is revealed by temperature differences in areas of the extremities as well as other regions of the body. However, what is needed is an imaging technique that is relatively inexpensive and can reveal the blood flow in real time. The IR imaging can show detailed venous system and small tempearture changes associated with blood flow. Six patients with vascular diseases were tested in a clinic set up. Their legs and feet were imaged. We observed large temperature differences (cooling of more than 10° C) at the foot, especially toes. More valuable information were obtained from the temperature distribution maps. IR thermography is potentially a very valuable tool for medical application, especially for vascular diseases.

Extreme Precipitation and High-Impact Landslides

NASA Technical Reports Server (NTRS)

Kirschbaum, Dalia; Adler, Robert; Huffman, George; Peters-Lidard, Christa

2012-01-01

It is well known that extreme or prolonged rainfall is the dominant trigger of landslides; however, there remain large uncertainties in characterizing the distribution of these hazards and meteorological triggers at the global scale. Researchers have evaluated the spatiotemporal distribution of extreme rainfall and landslides at local and regional scale primarily using in situ data, yet few studies have mapped rainfall-triggered landslide distribution globally due to the dearth of landslide data and consistent precipitation information. This research uses a newly developed Global Landslide Catalog (GLC) and a 13-year satellite-based precipitation record from Tropical Rainfall Measuring Mission (TRMM) data. For the first time, these two unique products provide the foundation to quantitatively evaluate the co-occurence of precipitation and rainfall-triggered landslides globally. The GLC, available from 2007 to the present, contains information on reported rainfall-triggered landslide events around the world using online media reports, disaster databases, etc. When evaluating this database, we observed that 2010 had a large number of high-impact landslide events relative to previous years. This study considers how variations in extreme and prolonged satellite-based rainfall are related to the distribution of landslides over the same time scales for three active landslide areas: Central America, the Himalayan Arc, and central-eastern China. Several test statistics confirm that TRMM rainfall generally scales with the observed increase in landslide reports and fatal events for 2010 and previous years over each region. These findings suggest that the co-occurrence of satellite precipitation and landslide reports may serve as a valuable indicator for characterizing the spatiotemporal distribution of landslide-prone areas in order to establish a global rainfall-triggered landslide climatology. This research also considers the sources for this extreme rainfall, citing teleconnections from ENSO as likely contributors to regional precipitation variability. This work demonstrates the potential for using satellite-based precipitation estimates to identify potentially active landslide areas at the global scale in order to improve landslide cataloging and quantify landslide triggering at daily, monthly and yearly time scales.

Thrombus segmentation by texture dynamics from microscopic image sequences

NASA Astrophysics Data System (ADS)

Brieu, Nicolas; Serbanovic-Canic, Jovana; Cvejic, Ana; Stemple, Derek; Ouwehand, Willem; Navab, Nassir; Groher, Martin

2010-03-01

The genetic factors of thrombosis are commonly explored by microscopically imaging the coagulation of blood cells induced by injuring a vessel of mice or of zebrafish mutants. The latter species is particularly interesting since skin transparency permits to non-invasively acquire microscopic images of the scene with a CCD camera and to estimate the parameters characterizing the thrombus development. These parameters are currently determined by manual outlining, which is both error prone and extremely time consuming. Even though a technique for automatic thrombus extraction would be highly valuable for gene analysts, little work can be found, which is mainly due to very low image contrast and spurious structures. In this work, we propose to semi-automatically segment the thrombus over time from microscopic image sequences of wild-type zebrafish larvae. To compensate the lack of valuable spatial information, our main idea consists of exploiting the temporal information by modeling the variations of the pixel intensities over successive temporal windows with a linear Markov-based dynamic texture formalization. We then derive an image from the estimated model parameters, which represents the probability of a pixel to belong to the thrombus. We employ this probability image to accurately estimate the thrombus position via an active contour segmentation incorporating also prior and spatial information of the underlying intensity images. The performance of our approach is tested on three microscopic image sequences. We show that the thrombus is accurately tracked over time in each sequence if the respective parameters controlling prior influence and contour stiffness are correctly chosen.

Telescience - Concepts and contributions to the Extreme Ultraviolet Explorer mission

NASA Technical Reports Server (NTRS)

Marchant, Will; Dobson, Carl; Chakrabarti, Supriya; Malina, Roger F.

1987-01-01

It is shown how the contradictory goals of low-cost and fast data turnaround characterizing the Extreme Ultraviolet Explorer (EUVE) mission can be achieved via the early use of telescience style transparent tools and simulations. The use of transparent tools reduces the parallel development of capability while ensuring that valuable prelaunch experience is not lost in the operations phase. Efforts made to upgrade the 'EUVE electronics' simulator are described.

Monitoring Change in Temperate Coniferous Forest Ecosystems

NASA Technical Reports Server (NTRS)

Williams, Darrel (Technical Monitor); Woodcock, Curtis E.

2004-01-01

The primary goal of this research was to improve monitoring of temperate forest change using remote sensing. In this context, change includes both clearing of forest due to effects such as fire, logging, or land conversion and forest growth and succession. The Landsat 7 ETM+ proved an extremely valuable research tool in this domain. The Landsat 7 program has generated an extremely valuable transformation in the land remote sensing community by making high quality images available for relatively low cost. In addition, the tremendous improvements in the acquisition strategy greatly improved the overall availability of remote sensing images. I believe that from an historical prespective, the Landsat 7 mission will be considered extremely important as the improved image availability will stimulate the use of multitemporal imagery at resolutions useful for local to regional mapping. Also, Landsat 7 has opened the way to global applications of remote sensing at spatial scales where important surface processes and change can be directly monitored. It has been a wonderful experience to have participated on the Landsat 7 Science Team. The research conducted under this project led to contributions in four general domains: I. Improved understanding of the information content of images as a function of spatial resolution; II. Monitoring Forest Change and Succession; III. Development and Integration of Advanced Analysis Methods; and IV. General support of the remote sensing of forests and environmental change. This report is organized according to these topics. This report does not attempt to provide the complete details of the research conducted with support from this grant. That level of detail is provided in the 16 peer reviewed journal articles, 7 book chapters and 5 conference proceedings papers published as part of this grant. This report attempts to explain how the various publications fit together to improve our understanding of how forests are changing and how to monitor forest change with remote sensing. There were no new inventions that resulted from this grant.

Development of Novel Microsatellite Markers for the BBCC Oryza Genome (Poaceae) Using High-Throughput Sequencing Technology

PubMed Central

Peng, Suotang; Xu, Qun; Yuan, Xiaoping; Feng, Yue; Yu, Hanyong; Wang, Yiping; Wei, Xinghua

2014-01-01

Wild species of Oryza are extremely valuable sources of genetic material that can be used to broaden the genetic background of cultivated rice, and to increase its resistance to abiotic and biotic stresses. Until recently, there was no sequence information for the BBCC Oryza genome; therefore, no special markers had been developed for this genome type. The lack of suitable markers made it difficult to search for valuable genes in the BBCC genome. The aim of this study was to develop microsatellite markers for the BBCC genome. We obtained 13,991 SSR-containing sequences and designed 14,508 primer pairs. The most abundant was hexanuclelotide (31.39%), followed by trinucleotide (27.67%) and dinucleotide (19.04%). 600 markers were selected for validation in 23 accessions of Oryza species with the BBCC genome. A set of 495 markers produced clear amplified fragments of the expected sizes. The average number of alleles per locus (Na) was 2.5, ranging from 1 to 9. The genetic diversity per locus (He) ranged from 0 to 0.844 with a mean of 0.333. The mean polymorphism information content (PIC) was 0.290, and ranged from 0 to 0.825. Of the 495 markers, 12 were only found in the BB genome, 173 were unique to the CC genome, and 198 were also present in the AA genome. These microsatellite markers could be used to evaluate the phylogenetic relationships among different Oryza genomes, and to construct a genetic linkage map for locating and identifying valuable genes in the BBCC genome, and would also for marker-assisted breeding programs that included accessions with the AA genome, especially Oryza sativa. PMID:24632997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Danilovic, S.; Solanki, S. K.; Barthol, P.

Ellerman Bombs are signatures of magnetic reconnection, which is an important physical process in the solar atmosphere. How and where they occur is a subject of debate. In this paper, we analyze Sunrise/IMaX data, along with 3D MHD simulations that aim to reproduce the exact scenario proposed for the formation of these features. Although the observed event seems to be more dynamic and violent than the simulated one, simulations clearly confirm the basic scenario for the production of EBs. The simulations also reveal the full complexity of the underlying process. The simulated observations show that the Fe i 525.02 nm linemore » gives no information on the height where reconnection takes place. It can only give clues about the heating in the aftermath of the reconnection. However, the information on the magnetic field vector and velocity at this spatial resolution is extremely valuable because it shows what numerical models miss and how they can be improved.« less

Documentary evidence of past floods in Europe and their utility in flood frequency estimation

NASA Astrophysics Data System (ADS)

Kjeldsen, T. R.; Macdonald, N.; Lang, M.; Mediero, L.; Albuquerque, T.; Bogdanowicz, E.; Brázdil, R.; Castellarin, A.; David, V.; Fleig, A.; Gül, G. O.; Kriauciuniene, J.; Kohnová, S.; Merz, B.; Nicholson, O.; Roald, L. A.; Salinas, J. L.; Sarauskiene, D.; Šraj, M.; Strupczewski, W.; Szolgay, J.; Toumazis, A.; Vanneuville, W.; Veijalainen, N.; Wilson, D.

2014-09-01

This review outlines the use of documentary evidence of historical flood events in contemporary flood frequency estimation in European countries. The study shows that despite widespread consensus in the scientific literature on the utility of documentary evidence, the actual migration from academic to practical application has been limited. A detailed review of flood frequency estimation guidelines from different countries showed that the value of historical data is generally recognised, but practical methods for systematic and routine inclusion of this type of data into risk analysis are in most cases not available. Studies of historical events were identified in most countries, and good examples of national databases attempting to collate the available information were identified. The conclusion is that there is considerable potential for improving the reliability of the current flood risk assessments by harvesting the valuable information on past extreme events contained in the historical data sets.

Technology architecture guidelines for a health care system.

PubMed

Jones, D T; Duncan, R; Langberg, M L; Shabot, M M

2000-01-01

Although the demand for use of information technology within the healthcare industry is intensifying, relatively little has been written about guidelines to optimize IT investments. A technology architecture is a set of guidelines for technology integration within an enterprise. The architecture is a critical tool in the effort to control information technology (IT) operating costs by constraining the number of technologies supported. A well-designed architecture is also an important aid to integrating disparate applications, data stores and networks. The authors led the development of a thorough, carefully designed technology architecture for a large and rapidly growing health care system. The purpose and design criteria are described, as well as the process for gaining consensus and disseminating the architecture. In addition, the processes for using, maintaining, and handling exceptions are described. The technology architecture is extremely valuable to health care organizations both in controlling costs and promoting integration.

Technology architecture guidelines for a health care system.

PubMed Central

Jones, D. T.; Duncan, R.; Langberg, M. L.; Shabot, M. M.

2000-01-01

Although the demand for use of information technology within the healthcare industry is intensifying, relatively little has been written about guidelines to optimize IT investments. A technology architecture is a set of guidelines for technology integration within an enterprise. The architecture is a critical tool in the effort to control information technology (IT) operating costs by constraining the number of technologies supported. A well-designed architecture is also an important aid to integrating disparate applications, data stores and networks. The authors led the development of a thorough, carefully designed technology architecture for a large and rapidly growing health care system. The purpose and design criteria are described, as well as the process for gaining consensus and disseminating the architecture. In addition, the processes for using, maintaining, and handling exceptions are described. The technology architecture is extremely valuable to health care organizations both in controlling costs and promoting integration. PMID:11079913

Hair: a complementary source of bioanalytical information in forensic toxicology.

PubMed

Barroso, Mário; Gallardo, Eugenia; Vieira, Duarte Nuno; López-Rivadulla, Manuel; Queiroz, João António

2011-01-01

Hair has been used for years in the assessment and documentation of human exposure to drugs, as it presents characteristics that make it extremely valuable for this purpose, namely the fact that sample collection is performed in a noninvasive manner, under close supervision, the possibility of collecting a specimen reflecting a similar timeline in the case of claims or suspicion of a leak in the chain of custody, and the increased window of detection for the drugs. For these reasons, testing for drugs in hair provides unique and useful information in several fields of toxicology, from which the most prominent is the possibility of studying individual drug use histories by means of segmental analysis. This paper will review the unique role of hair as a complementary sample in documenting human exposure to drugs in the fields of clinical and forensic toxicology and workplace drug testing.

North Dakota

USGS Publications Warehouse

,

1999-01-01

North Dakota prairies contain numerous wetlands. The complex functions of these prairie wetlands have been of interest for decades. The hydrology, water chemistry, and biological characteristics of these wetlands are highly variable because of extreme warm/cold and wet/dry conditions. The U.S. Geological Survey (USGS) has been conducting studies (fig. 1) to gain insight into the functions of the prairie wetlands. The USGS Northern Prairie Wildlife Research Center in Jamestown has maintained an active wetland research program since the mid-1960’s. Current work in North Dakota began in 1978, and focuses on the response of biological communities to climate-induced variations in hydrology and chemistry, and on evaluating the success of previously drained wetlands restored under the Conservation Reserve Program (CRP) and on similar lands. The information provided from this long-term study has provided the bulk of our knowledge about prairie wetlands, and has provided land managers with valuable information to manage the Nation’s prairie wetland resource.

Hidden values in bauxite residue (red mud): recovery of metals.

PubMed

Liu, Yanju; Naidu, Ravi

2014-12-01

Bauxite residue (red mud) is a hazardous waste generated from alumina refining industries. Unless managed properly, red mud poses significant risks to the local environment due to its extreme alkalinity and its potential impacts on surface and ground water quality. The ever-increasing generation of red mud poses significant challenges to the aluminium industries from management perspectives given the low proportion that are currently being utilized beneficially. Red mud, in most cases, contains elevated concentrations of iron in addition to aluminium, titanium, sodium and valuable rare earth elements. Given the scarcity of iron supply globally, the iron content of red mud has attracted increasing research interest. This paper presents a critical overview of the current techniques employed for iron recovery from red mud. Information on the recovery of other valuable metals is also reviewed to provide an insight into the full potential usage of red mud as an economic resource rather than a waste. Traditional hydrometallurgy and pyrometallurgy are being investigated continuously. However, in this review several new techniques are introduced that consider the process of iron recovery from red mud. An integrated process which can achieve multiple additional values from red mud is much preferred over the single process methods. The information provided here should help to improve the future management and utilization of red mud. Copyright © 2014 Elsevier Ltd. All rights reserved.

Comprehensive evaluation of transportation projects : a toolkit for sketch planning.

DOT National Transportation Integrated Search

2010-10-01

A quick-response project-planning tool can be extremely valuable in anticipating the congestion, safety, : emissions, and other impacts of large-scale network improvements and policy implementations. This report : identifies the advantages and limita...

The development of a white cane which navigates the visually impaired.

PubMed

Shiizu, Yuriko; Hirahara, Yoshiaki; Yanashima, Kenji; Magatani, Kazushige

2007-01-01

In this paper, we describe about a developed navigation system that supports the independent walking of the visually impaired in the indoor space. This system is composed of colored navigation lines, RFID tags and an intelligent white cane. In our system, some colored marking tapes are set on along the walking route. These lines are called navigation line. And also RFID tags are set on this line at each landmark point. The intelligent white cane can sense a color of navigation line and receive tag information. By vibration of white cane, the system informs the visually impaired that he/she is walking along the navigation line. At the landmark point, the system also notifies area information to him/her by pre-recorded voice. Ten normal subjects who were blind folded with an eye mask were tested with this system. All of them were able to walk along the navigation line. The performance of the area information system was good. Therefore, we have concluded that our system will be extremely valuable in supporting the activities of the visually impaired.

The Astrophysics of Merging Black Holes

NASA Technical Reports Server (NTRS)

Schnittman, Jeremy D.

2011-01-01

When two supermassive black holes (SMBHs) approach within 1-10 mpc, gravitational wave (GW) losses begin to dominate the evolution of the binary, pushing the system to merge in a relatively small time. During this final inspiral regime, the system will emit copious energy in GWs, which should be directly detectable by pulsar timing arrays and space-based interferometers. At the same time, any gas or stars in the immediate vicinity of the merging 5MBHs can get heated and produce bright electromagnetic (EM) counterparts to the GW signals. We present here a number of possible mechanisms by which simultaneous EM and GW signals will yield valuable new information about galaxy evolution, accretion disk dynamics, and fundamental physics in the most extreme gravitational fields.

Electromagnetic Signatures of SMBH Coalescence

NASA Technical Reports Server (NTRS)

Schnittman, Jeremy

2012-01-01

When two supermassive black holes (SMBHs) approach within 1-10 mpc, gravitational wave (GW) losses begin to dominate the evolution of the binary, pushing the system to merge in a relatively small time. During this final inspiral regime, the system will emit copious energy in GWs, which should be directly detectable by pulsar timing arrays and space-based interferometers. At the same time, any gas or stars in the immediate vicinity of the merging 5MBHs can get heated and produce bright electromagnetic (EM) counterparts to the GW signals. We present here a number of possible mechanisms by which simultaneous EM and GW signals will yield valuable new information about galaxy evolution, accretion disk dynamics, and fundamental physics in the most extreme gravitational fields.

Unexpected findings of a female team in Xochimilco, Mexico.

PubMed

Martínez-Salgado, C

1999-01-01

This is a reflection about the methodological circumstances that led the author to certain unexpected information during the course of a qualitative approach to the perception of health problems of a group of poor families in the south of Mexico City. Special attention is paid to the influence of the research team composition (four women with different professional backgrounds, ages, marital statuses, and styles of personal interaction) and the psychoanalytic technique that influenced the study. The inclusion of people of different ages, professions, and personality traits proved extremely valuable both as a means of widening the possibilities for empathetic relations between the research group and the population studied and for increasing the shades of meaning that the team was able to capture.

Multiple scales modelling approaches to social interaction in crowd dynamics and crisis management. Comment on "Human behaviours in evacuation crowd dynamics: From modelling to "big data" toward crisis management" by Nicola Bellomo et al.

NASA Astrophysics Data System (ADS)

Trucu, Dumitru

2016-09-01

In this comprehensive review concerning the modelling of human behaviours in crowd dynamics [3], the authors explore a wide range of mathematical approaches spanning over multiple scales that are suitable to describe emerging crowd behaviours in extreme situations. Focused on deciphering the key aspects leading to emerging crowd patterns evolutions in challenging times such as those requiring an evacuation on a complex venue, the authors address this complex dynamics at both microscale (individual level), mesoscale (probability distributions of interacting individuals), and macroscale (population level), ultimately aiming to gain valuable understanding and knowledge that would inform decision making in managing crisis situations.

Black Hole Coalescence: The Gravitational Wave Driven Phase

NASA Technical Reports Server (NTRS)

Schnittman, Jeremy D.

2011-01-01

When two supermassive black holes (SMBHS) approach within 1-10 mpc, gravitational wave (GW) losses begin to dominate the evolution of the binary, pushing the system to merge in a relatively small time. During this final inspiral regime, the system will emit copious energy in GWs, which should be directly detectable by pulsar timing arrays and space-based interferometers. At the same time, any gas or stars in the immediate vicinity of the merging 5MBHs can get heated and produce bright electromagnetic (EM) counterparts to the GW signals. We present here a number of possible mechanisms by which simultaneous EM and GW signals will yield valuable new information about galaxy evolution, accretion disk dynamics, and fundamental physics in the most extreme gravitational fields.

Integrated quantitative fractal polarimetric analysis of monolayer lung cancer cells

NASA Astrophysics Data System (ADS)

Shrestha, Suman; Zhang, Lin; Quang, Tri; Farrahi, Tannaz; Narayan, Chaya; Deshpande, Aditi; Na, Ying; Blinzler, Adam; Ma, Junyu; Liu, Bo; Giakos, George C.

2014-05-01

Digital diagnostic pathology has become one of the most valuable and convenient advancements in technology over the past years. It allows us to acquire, store and analyze pathological information from the images of histological and immunohistochemical glass slides which are scanned to create digital slides. In this study, efficient fractal, wavelet-based polarimetric techniques for histological analysis of monolayer lung cancer cells will be introduced and different monolayer cancer lines will be studied. The outcome of this study indicates that application of fractal, wavelet polarimetric principles towards the analysis of squamous carcinoma and adenocarcinoma cancer cell lines may be proved extremely useful in discriminating among healthy and lung cancer cells as well as differentiating among different lung cancer cells.

Western scrub-jays allocate longer observation time to more valuable information.

PubMed

Watanabe, Arii; Grodzinski, Uri; Clayton, Nicola S

2014-07-01

When humans mentally reconstruct past events and imagine future scenarios, their subjective experience of mentally time travelling is accompanied by the awareness of doing so. Despite recent popularity of studying episodic memory in animals, such phenomenological consciousness has been extremely difficult to demonstrate without agreed behavioural markers of consciousness in non-linguistic subjects. We presented western scrub-jays (Aphelocoma californica) with a task requiring them to allocate observing time between two peepholes to see food being hidden in either of two compartments, one where observing the hiding location was necessary to later relocate the food, and another where food could easily be found without watching. Jays first separately experienced these consequences of possessing information in each compartment and subsequently, once given a choice, made more looks and spent more time looking into the compartment where information was necessary than into the compartment where it was unnecessary. Thus, the jays can collect information to solve a future problem. Moreover, they can differentiate sources of information according to their potential value and modify behaviour to efficiently collect important, usable information. This is the first evidence of metacognition in a species that passes the behavioural criteria for both retrospective and prospective mental time travel.

The Lake Victoria Intense Storm Early Warning System (VIEWS)

NASA Astrophysics Data System (ADS)

Thiery, Wim; Gudmundsson, Lukas; Bedka, Kristopher; Semazzi, Fredrick; Lhermitte, Stef; Willems, Patrick; van Lipzig, Nicole; Seneviratne, Sonia I.

2017-04-01

Weather extremes have harmful impacts on communities around Lake Victoria in East Africa. Every year, intense nighttime thunderstorms cause numerous boating accidents on the lake, resulting in thousands of deaths among fishermen. Operational storm warning systems are therefore crucial. Here we complement ongoing early warning efforts based on NWP, by presenting a new satellite data-driven storm prediction system, the prototype Lake Victoria Intense storm Early Warning System (VIEWS). VIEWS derives predictability from the correlation between afternoon land storm activity and nighttime storm intensity on Lake Victoria, and relies on logistic regression techniques to forecast extreme thunderstorms from satellite observations. Evaluation of the statistical model reveals that predictive power is high and independent of the input dataset. We then optimise the configuration and show that also false alarms contain valuable information. Our results suggest that regression-based models that are motivated through process understanding have the potential to reduce the vulnerability of local fishing communities around Lake Victoria. The experimental prediction system is publicly available under the MIT licence at http://github.com/wthiery/VIEWS.

Early warnings of hazardous thunderstorms over Lake Victoria

NASA Astrophysics Data System (ADS)

Thiery, Wim; Gudmundsson, Lukas; Bedka, Kristopher; Semazzi, Fredrick H. M.; Lhermitte, Stef; Willems, Patrick; van Lipzig, Nicole P. M.; Seneviratne, Sonia I.

2017-07-01

Weather extremes have harmful impacts on communities around Lake Victoria in East Africa. Every year, intense nighttime thunderstorms cause numerous boating accidents on the lake, resulting in thousands of deaths among fishermen. Operational storm warning systems are therefore crucial. Here we complement ongoing early warning efforts based on numerical weather prediction, by presenting a new satellite data-driven storm prediction system, the prototype Lake Victoria Intense storm Early Warning System (VIEWS). VIEWS derives predictability from the correlation between afternoon land storm activity and nighttime storm intensity on Lake Victoria, and relies on logistic regression techniques to forecast extreme thunderstorms from satellite observations. Evaluation of the statistical model reveals that predictive power is high and independent of the type of input dataset. We then optimise the configuration and show that false alarms also contain valuable information. Our results suggest that regression-based models that are motivated through process understanding have the potential to reduce the vulnerability of local fishing communities around Lake Victoria. The experimental prediction system is publicly available under the MIT licence at http://github.com/wthiery/VIEWS.

ENSO detection and use to inform the operation of large scale water systems

NASA Astrophysics Data System (ADS)

Pham, Vuong; Giuliani, Matteo; Castelletti, Andrea

2016-04-01

El Nino Southern Oscillation (ENSO) is a large-scale, coupled ocean-atmosphere phenomenon occurring in the tropical Pacific Ocean, and is considered one of the most significant factors causing hydro-climatic anomalies throughout the world. Water systems operations could benefit from a better understanding of this global phenomenon, which has the potential for enhancing the accuracy and lead-time of long-range streamflow predictions. In turn, these are key to design interannual water transfers in large scale water systems to contrast increasingly frequent extremes induced by changing climate. Despite the ENSO teleconnection is well defined in some locations such as Western USA and Australia, there is no consensus on how it can be detected and used in other river basins, particularly in Europe, Africa, and Asia. In this work, we contribute a general framework relying on Input Variable Selection techniques for detecting ENSO teleconnection and using this information for improving water reservoir operations. Core of our procedure is the Iterative Input variable Selection (IIS) algorithm, which is employed to find the most relevant determinants of streamflow variability for deriving predictive models based on the selected inputs as well as to find the most valuable information for conditioning operating decisions. Our framework is applied to the multipurpose operations of the Hoa Binh reservoir in the Red River basin (Vietnam), taking into account hydropower production, water supply for irrigation, and flood mitigation during the monsoon season. Numerical results show that our framework is able to quantify the relationship between the ENSO fluctuations and the Red River basin hydrology. Moreover, we demonstrate that such ENSO teleconnection represents valuable information for improving the operations of Hoa Binh reservoir.

A Palaeozoic Puzzle in Cenozoic Science.

ERIC Educational Resources Information Center

Mikkelsen, Tom

1982-01-01

The sword-tailed horseshoe crab (Limulus polyphemus) has developed its own defense against bacteria surrounding it. This defense system, under the name "Limulus test," now provides medicine and hygiene with a valuable means of detecting bacterial endotoxins at extremely low levels. (Author/JN)

Experimental realization of open magnetic shielding

NASA Astrophysics Data System (ADS)

Gu, C.; Chen, S.; Pang, T.; Qu, T.-M.

2017-05-01

The detection of extremely low magnetic fields has various applications in the area of fundamental research, medical diagnosis, and industry. Extracting the valuable signals from noises often requires magnetic shielding facilities. We demonstrated directly from Maxwell's equations that specifically designed superconductor coils can exactly shield the magnetic field to an extremely low value. We experimentally confirmed this effect in the frequency spectrum of 0.01-10 000 Hz and improved the electromagnetic environment in a hospital, a leading hospital in magnetocardiograph study in China.

ANGLICO: Birth, Life, Death and Resurrection

DTIC Science & Technology

2001-01-01

REPORT DATE 3. REPORT TYPE AND DATES COVERED STUDENT RESEARCH PAPER 4. TITLE AND SUBTITLE ANGLICO: BIRTH, LIFE, DEATH AND RESURRECTION. 5...Lieutenant Colonel Bright concerning these working papers were extremely valuable in the writing of this paper, Hearafter cited as the Bright Papaers . 2

HISTOPATHOLOGICAL BIOMARKERS AS INTEGRATORS OF ANTHROPOGENIC AND ENVIRONMENTAL STRESSORS

EPA Science Inventory

Histopathology is an extremely useful tool for assessing effects of exposure to stressors at the level of the individual. Even though the histopathological approach is somewhat qualitative, it is very valuable because the observed lesions represent an integration of cumulative e...

HISTOPATHOLOGICAL BIOMARKERS AS INTEGRATORS OF CHEMICAL CONTAMINANT EXPOSURE AND EFFECTS IN FISH

EPA Science Inventory

Histopathology can be an extremely useful tool for assessing effects of chemical exposure in fish at the level of the individual. Although somewhat qualitative, the histopathological approach is especially valuable because observed lesions represent an integration of cumulative e...

Determination of Differential Emission Measure from Solar Extreme Ultraviolet Images

NASA Astrophysics Data System (ADS)

Su, Yang; Veronig, Astrid M.; Hannah, Iain G.; Cheung, Mark C. M.; Dennis, Brian R.; Holman, Gordon D.; Gan, Weiqun; Li, Youping

2018-03-01

The Atmospheric Imaging Assembly (AIA) on board the Solar Dynamic Observatory (SDO) has been providing high-cadence, high-resolution, full-disk UV-visible/extreme ultraviolet (EUV) images since 2010, with the best time coverage among all the solar missions. A number of codes have been developed to extract plasma differential emission measures (DEMs) from AIA images. Although widely used, they cannot effectively constrain the DEM at flaring temperatures with AIA data alone. This often results in much higher X-ray fluxes than observed. One way to solve the problem is by adding more constraint from other data sets (such as soft X-ray images and fluxes). However, the spatial information of plasma DEMs are lost in many cases. In this Letter, we present a different approach to constrain the DEMs. We tested the sparse inversion code and show that the default settings reproduce X-ray fluxes that could be too high. Based on the tests with both simulated and observed AIA data, we provided recommended settings of basis functions and tolerances. The new DEM solutions derived from AIA images alone are much more consistent with (thermal) X-ray observations, and provide valuable information by mapping the thermal plasma from ∼0.3 to ∼30 MK. Such improvement is a key step in understanding the nature of individual X-ray sources, and particularly important for studies of flare initiation.

Probabilistic seasonal Forecasts to deterministic Farm Leve Decisions: Innovative Approach

NASA Astrophysics Data System (ADS)

Mwangi, M. W.

2015-12-01

Climate change and vulnerability are major challenges in ensuring household food security. Climate information services have the potential to cushion rural households from extreme climate risks. However, most the probabilistic nature of climate information products is not easily understood by majority of smallholder farmers. Despite the probabilistic nature, climate information have proved to be a valuable climate risk adaptation strategy at the farm level. This calls for innovative ways to help farmers understand and apply climate information services to inform their farm level decisions. The study endeavored to co-design and test appropriate innovation systems for climate information services uptake and scale up necessary for achieving climate risk development. In addition it also determined the conditions necessary to support the effective performance of the proposed innovation system. Data and information sources included systematic literature review, secondary sources, government statistics, focused group discussions, household surveys and semi-structured interviews. Data wasanalyzed using both quantitative and qualitative data analysis techniques. Quantitative data was analyzed using the Statistical Package for Social Sciences (SPSS) software. Qualitative data was analyzed using qualitative techniques, which involved establishing the categories and themes, relationships/patterns and conclusions in line with the study objectives. Sustainable livelihood, reduced household poverty and climate change resilience were the impact that resulted from the study.

Disentangling conscious from unconscious cognitive processing with event-related EEG potentials.

PubMed

Rohaut, B; Naccache, L

By looking for properties of consciousness, cognitive neuroscience studies have dramatically enlarged the scope of unconscious cognitive processing. This emerging knowledge inspired the development of new approaches allowing clinicians to probe and disentangle conscious from unconscious cognitive processes in non-communicating brain-injured patients both in terms of behaviour and brain activity. This information is extremely valuable in order to improve diagnosis and prognosis in such patients both at acute and chronic settings. Reciprocally, the growing observations coming from such patients suffering from disorders of consciousness provide valuable constraints to theoretical models of consciousness. In this review we chose to illustrate these recent developments by focusing on brain signals recorded with EEG at bedside in response to auditory stimuli. More precisely, we present the respective EEG markers of unconscious and conscious processing of two classes of auditory stimuli (sounds and words). We show that in both cases, conscious access to the corresponding representation (e.g.: auditory regularity and verbal semantic content) share a similar neural signature (P3b and P600/LPC) that can be distinguished from unconscious processing occurring during an earlier stage (MMN and N400). We propose a two-stage serial model of processing and discuss how unconscious and conscious signatures can be measured at bedside providing relevant informations for both diagnosis and prognosis of consciousness recovery. These two examples emphasize how fruitful can be the bidirectional approach exploring cognition in healthy subjects and in brain-damaged patients. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

INVESTIGATIONS IN PANAMA DURING THE SUMMER OF 1930.

PubMed

Faust, E C

1931-01-09

The material obtained from these investigations has indicated to the writer that the area studied offers extremely valuable opportunities for helminthological and protozoological work. The data obtained will serve as the basis for several important papers which will be published in the near future.

Study of Environmental Data Complexity using Extreme Learning Machine

NASA Astrophysics Data System (ADS)

Leuenberger, Michael; Kanevski, Mikhail

2017-04-01

The main goals of environmental data science using machine learning algorithm deal, in a broad sense, around the calibration, the prediction and the visualization of hidden relationship between input and output variables. In order to optimize the models and to understand the phenomenon under study, the characterization of the complexity (at different levels) should be taken into account. Therefore, the identification of the linear or non-linear behavior between input and output variables adds valuable information for the knowledge of the phenomenon complexity. The present research highlights and investigates the different issues that can occur when identifying the complexity (linear/non-linear) of environmental data using machine learning algorithm. In particular, the main attention is paid to the description of a self-consistent methodology for the use of Extreme Learning Machines (ELM, Huang et al., 2006), which recently gained a great popularity. By applying two ELM models (with linear and non-linear activation functions) and by comparing their efficiency, quantification of the linearity can be evaluated. The considered approach is accompanied by simulated and real high dimensional and multivariate data case studies. In conclusion, the current challenges and future development in complexity quantification using environmental data mining are discussed. References - Huang, G.-B., Zhu, Q.-Y., Siew, C.-K., 2006. Extreme learning machine: theory and applications. Neurocomputing 70 (1-3), 489-501. - Kanevski, M., Pozdnoukhov, A., Timonin, V., 2009. Machine Learning for Spatial Environmental Data. EPFL Press; Lausanne, Switzerland, p.392. - Leuenberger, M., Kanevski, M., 2015. Extreme Learning Machines for spatial environmental data. Computers and Geosciences 85, 64-73.

Global Distribution of Extreme Precipitation and High-Impact Landslides in 2010 Relative to Previous Years

NASA Technical Reports Server (NTRS)

Kirschbaum, Dalia; Adler, Robert; Adler, David; Peters-Lidard, Christa; Huffman, George

2012-01-01

It is well known that extreme or prolonged rainfall is the dominant trigger of landslides worldwide. While research has evaluated the spatiotemporal distribution of extreme rainfall and landslides at local or regional scales using in situ data, few studies have mapped rainfall-triggered landslide distribution globally due to the dearth of landslide data and consistent precipitation information. This study uses a newly developed Global Landslide Catalog (GLC) and a 13-year satellite-based precipitation record from TRMM data. For the first time, these two unique products provide the foundation to quantitatively evaluate the co-occurrence of precipitation and landslides globally. Evaluation of the GLC indicates that 2010 had a large number of high-impact landslide events relative to previous years. This study considers how variations in extreme and prolonged satellite-based rainfall are related to the distribution of landslides over the same time scales for three active landslide areas: Central America, the Himalayan Arc, and central-eastern China. Several test statistics confirm that TRMM rainfall generally scales with the observed increase in landslide reports and fatal events for 2010 and previous years over each region. These findings suggest that the co-occurrence of satellite precipitation and landslide reports may serve as a valuable indicator for characterizing the spatiotemporal distribution of landslide-prone areas in order to establish a global rainfall-triggered landslide climatology. This study characterizes the variability of satellite precipitation data and reported landslide activity at the globally scale in order to improve landslide cataloging, forecasting and quantify potential triggering sources at daily, monthly and yearly time scales.

The IRAF Fabry-Perot analysis package: Ring fitting

NASA Technical Reports Server (NTRS)

Shopbell, P. L.; Bland-Hawthorn, J.; Cecil, G.

1992-01-01

As introduced at ADASSI, a Fabry-Perot analysis package for IRAF is currently under development as a joint effort of ourselves and Frank Valdes of the IRAF group. Although additional portions of the package were also implemented, we report primarily on the development of a robust ring fitting task, useful for fitting the calibration rings obtained in Fabry-Perot observations. The general equation of an ellipse is fit to the shape of the rings, providing information on ring center, ellipticity, and position angle. Such parameters provide valuable information on the wavelength response of the etalon and the geometric stability of the system. Appropriate statistical weighting is applied to the pixels to account for increasing numbers with radius, the Lorentzian cross-section, and uneven illumination. The major problems of incomplete, non-uniform, and multiple rings are addressed with the final task capable of fitting rings regardless of center, cross-section, or completion. The task requires only minimal user intervention, allowing large numbers of rings to be fit in an extremely automated manner.

Standardization of an in vitro Model for Evaluating the Bioavailability of Topically Applied Compounds on Damaged Skin: Application to Sunscreen Analysis.

PubMed

Jacques-Jamin, Carine; Jeanjean-Miquel, Corinne; Domergue, Anaïs; Bessou-Touya, Sandrine; Duplan, Hélène

2017-01-01

Information is lacking on the dermal penetration of topically applied formulations on in vitro skin models, under conditions where the stratum corneum (SC) is damaged. Therefore, we have developed a standardized in vitro barrier-disrupted skin model using tape stripping. Different tape stripping conditions were evaluated using histology, transepidermal water loss, infrared densitometry, and caffeine absorption. The effects of tape stripping were comparable using pig and human skin. Optimized conditions were used to test the effect of SC damage and UV irradiation on the absorption of an UV filter combination present in a sunscreen. The bioavailability of the filters was extremely low regardless of the extent of skin damage, suggesting bioavailability would not be increased if the consumer applied the sunscreen to sun-damaged skin. This standardized in vitro methodology using pig or human skin for damaged skin will add valuable information for the safety assessment of topically applied products. © 2017 S. Karger AG, Basel.

The earliest drawings of datable auroras and a two-tail comet from the Syriac Chronicle of Zūqnīn

NASA Astrophysics Data System (ADS)

Hayakawa, Hisashi; Mitsuma, Yasuyuki; Fujiwara, Yasunori; Kawamura, Akito Davis; Kataoka, Ryuho; Ebihara, Yusuke; Kosaka, Shunsuke; Iwahashi, Kiyomi; Tamazawa, Harufumi; Isobe, Hiroaki

2017-04-01

People have probably been watching the sky since the beginning of human history. Observers in pre-telescopic ages recorded anomalous events, which now provide uniquely valuable information for modern scientists. Records that include drawings are particularly useful, since the verbal expressions recorded by pre-telescopic observers, who did not know the physical nature of the phenomena, are often ambiguous. However, drawings concerning specific datable events in the historical documents are far fewer than the verbal records. Therefore, in this paper we show the possible earliest drawings of datable auroras and a two-tail comet included in a manuscript of the Chronicle of Zūqnīn, a Syriac chronicle up to 775/776 CE, to interpret their nature. Careful perusing the original Syriac autograph manuscript, MS Vat.Sir.162, provide not only historical facts in the realm around Amida, but also information concerning low-latitude aurora observations due to extreme space weather events and the existence of sun-grazing comets.

Diagnostic Accuracy of Full-Body Linear X-Ray Scanning in Multiple Trauma Patients in Comparison to Computed Tomography.

PubMed

Jöres, A P W; Heverhagen, J T; Bonél, H; Exadaktylos, A; Klink, T

2016-02-01

The purpose of this study was to evaluate the diagnostic accuracy of full-body linear X-ray scanning (LS) in multiple trauma patients in comparison to 128-multislice computed tomography (MSCT). 106 multiple trauma patients (female: 33; male: 73) were retrospectively included in this study. All patients underwent LS of the whole body, including extremities, and MSCT covering the neck, thorax, abdomen, and pelvis. The diagnostic accuracy of LS for the detection of fractures of the truncal skeleton and pneumothoraces was evaluated in comparison to MSCT by two observers in consensus. Extremity fractures detected by LS were documented. The overall sensitivity of LS was 49.2 %, the specificity was 93.3 %, the positive predictive value was 91 %, and the negative predictive value was 57.5 %. The overall sensitivity for vertebral fractures was 16.7 %, and the specificity was 100 %. The sensitivity was 48.7 % and the specificity 98.2 % for all other fractures. Pneumothoraces were detected in 12 patients by CT, but not by LS. 40 extremity fractures were detected by LS, of which 4 fractures were dislocated, and 2 were fully covered by MSCT. The diagnostic accuracy of LS is limited in the evaluation of acute trauma of the truncal skeleton. LS allows fast whole-body X-ray imaging, and may be valuable for detecting extremity fractures in trauma patients in addition to MSCT.  The overall sensitivity of LS for truncal skeleton injuries in multiple-trauma patients was < 50 %. The diagnostic reference standard MSCT is the preferred and reliable imaging modality. LS may be valuable for quick detection of extremity fractures. © Georg Thieme Verlag KG Stuttgart · New York.

A navigation system for the visually impaired using colored navigation lines and RFID tags.

PubMed

Seto, First Tatsuya

2009-01-01

In this paper, we describe about a developed navigation system that supports the independent walking of the visually impaired in the indoor space. Our developed instrument consists of a navigation system and a map information system. These systems are installed on a white cane. Our navigation system can follow a colored navigation line that is set on the floor. In this system, a color sensor installed on the tip of a white cane senses the colored navigation line, and the system informs the visually impaired that he/she is walking along the navigation line by vibration. The color recognition system is controlled by a one-chip microprocessor and this system can discriminate 6 colored navigation lines. RFID tags and a receiver for these tags are used in the map information system. The RFID tags and the RFID tag receiver are also installed on a white cane. The receiver receives tag information and notifies map information to the user by mp3 formatted pre-recorded voice. Three normal subjects who were blindfolded with an eye mask were tested with this system. All of them were able to walk along the navigation line. The performance of the map information system was good. Therefore, our system will be extremely valuable in supporting the activities of the visually impaired.

BIOLOGICAL EFFECTS AND DOSIMETRY OF STATIC AND ELF (EXTREMELY LOW FREQUENCY) ELECTROMAGNETIC FIELDS

EPA Science Inventory

The book offers a good introduction to the research field for students, as well as a valuable overall review for the experienced investigator. The six chapters on interactions provide concise descriptions of physical processes for natural and man-made environmental exposures and ...

Endocrine Regulation of Bone and Energy Metabolism in Hibernating Mammals

PubMed Central

Doherty, Alison H.; Florant, Gregory L.; Donahue, Seth W.

2014-01-01

Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships between bone, fat, reproductive, and brain tissues have come to light. These systems share interconnected regulatory mechanisms of energy metabolism that potentially protect the skeleton during hibernation. This review focuses on the endocrine and neuroendocrine regulation of bone/fat/energy metabolism in hibernators. Hibernators appear to have unique mechanisms that protect musculoskeletal tissues while catabolizing their abundant stores of fat. Furthermore, the bone remodeling processes that normally cause disuse-induced bone loss in non-hibernators are compared to bone remodeling processes in hibernators, and possible adaptations of the bone signaling pathways that protect the skeleton during hibernation are discussed. Understanding the biological mechanisms that allow hibernators to survive the prolonged disuse and fasting associated with extreme environmental challenges will provide critical information regarding the limit of convergence in mammalian systems and of skeletal plasticity, and may contribute valuable insight into the etiology and treatment of human diseases. PMID:24556365

InSAR constraints on soil moisture evolution after the March 2015 extreme precipitation event in Chile.

PubMed

Scott, C P; Lohman, R B; Jordan, T E

2017-07-07

Constraints on soil moisture can guide agricultural practices, act as input into weather, flooding and climate models and inform water resource policies. Space-based interferometric synthetic aperture radar (InSAR) observations provide near-global coverage, even in the presence of clouds, of proxies for soil moisture derived from the amplitude and phase content of radar imagery. We describe results from a 1.5 year-long InSAR time series spanning the March, 2015 extreme precipitation event in the hyperarid Atacama desert of Chile, constraining the immediate increase in soil moisture and drying out over the following months, as well as the response to a later, smaller precipitation event. The inferred temporal evolution of soil moisture is remarkably consistent between independent, overlapping SAR tracks covering a region ~100 km in extent. The unusually large rain event, combined with the extensive spatial and temporal coverage of the SAR dataset, present an unprecedented opportunity to image the time-evolution of soil characteristics over different surface types. Constraints on the timescale of shallow water storage after precipitation events are increasingly valuable as global water resources continue to be stretched to their limits and communities continue to develop in flood-prone areas.

High-throughput genotyping for species identification and diversity assessment in germplasm collections.

PubMed

Mason, Annaliese S; Zhang, Jing; Tollenaere, Reece; Vasquez Teuber, Paula; Dalton-Morgan, Jessica; Hu, Liyong; Yan, Guijun; Edwards, David; Redden, Robert; Batley, Jacqueline

2015-09-01

Germplasm collections provide an extremely valuable resource for breeders and researchers. However, misclassification of accessions by species often hinders the effective use of these collections. We propose that use of high-throughput genotyping tools can provide a fast, efficient and cost-effective way of confirming species in germplasm collections, as well as providing valuable genetic diversity data. We genotyped 180 Brassicaceae samples sourced from the Australian Grains Genebank across the recently released Illumina Infinium Brassica 60K SNP array. Of these, 76 were provided on the basis of suspected misclassification and another 104 were sourced independently from the germplasm collection. Presence of the A- and C-genomes combined with principle components analysis clearly separated Brassica rapa, B. oleracea, B. napus, B. carinata and B. juncea samples into distinct species groups. Several lines were further validated using chromosome counts. Overall, 18% of samples (32/180) were misclassified on the basis of species. Within these 180 samples, 23/76 (30%) supplied on the basis of suspected misclassification were misclassified, and 9/105 (9%) of the samples randomly sourced from the Australian Grains Genebank were misclassified. Surprisingly, several individuals were also found to be the product of interspecific hybridization events. The SNP (single nucleotide polymorphism) array proved effective at confirming species, and provided useful information related to genetic diversity. As similar genomic resources become available for different crops, high-throughput molecular genotyping will offer an efficient and cost-effective method to screen germplasm collections worldwide, facilitating more effective use of these valuable resources by breeders and researchers. © 2015 John Wiley & Sons Ltd.

77 FR 51807 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... Minimum Data Elements (MDEs) for the National Breast and Cervical Cancer Early Detection Program (NBCCEDP... screening and early detection tests for breast and cervical cancer. Mammography is extremely valuable as an early detection tool because it can detect breast cancer well before the woman can feel the lump, when...

Groundwater: Illinois' Buried Treasure. Education Activity Guide.

ERIC Educational Resources Information Center

Environmental Education Association of Illinois, Chicago.

Groundwater is an extremely valuable resource that many feel has been too long neglected and taken for granted. There is growing recognition in Illinois and throughout the United States that comprehensive groundwater protection measures are vital. Illinois embarked on a course in protecting groundwater resources with the passage of the Illinois…

Properties and uses of concrete, appendix B

NASA Technical Reports Server (NTRS)

Corley, Gene

1992-01-01

Concretes that can now be formed have properties which may make them valuable for lunar or space construction. These properties include high compressive strength, good flexural strength (when reinforced), and favorable responses to temperature extremes (even increased strength at low temperatures). These and other properties of concrete are discussed.

Critical thermal maxima of two geographic strains of channel and hybrid catfish

USDA-ARS?s Scientific Manuscript database

Critical thermal maxima have been used extensively to provide physiologically and ecologically valuable reference points that identify early signs of thermal stress. In catfish pond culture, daily temperature maxima up to 36'C and daily fluctuations of as much as 6'Care observed. These extreme condi...

The Wearable Motherboard: a flexible information infrastructure or sensate liner for medical applications.

PubMed

Park, S; Gopalsamy, C; Rajamanickam, R; Jayaraman, S

1999-01-01

Research on the design and development of a Sensate Liner for Combat Casualty Care has led to the realization of the world's first Wearable Motherboard or an "intelligent" garment for the 21st Century. This Georgia Tech Wearable Motherboard (GTWM) provides an extremely versatile framework for the incorporation of sensing, monitoring and information processing devices. The principal advantage of GTWM is that it provides, for the first time, a very systematic way of monitoring the vital signs of humans in an unobtrusive manner. Appropriate sensors have been "plugged" into this motherboard using the developed Interconnection Technology and attached to any part of the individual being monitored, thereby creating a flexible wearable monitoring device. The flexible data bus integrated into the structure transmits the information to monitoring devices such as an EKG Machine, a temperature recorder, a voice recorder, etc. The bus also serves to transmit information to the sensors (and hence, the wearer) from external sources, thus making GTWM a valuable information infrastructure. GTWM is lightweight and can be worn easily by anyone--from infants to senior citizens. GTWM has enormous potential for applications in fields such as telemedicine, monitoring of patients in post-operative recovery, the prevention of SIDS (sudden infant death syndrome), and monitoring of astronauts, athletes, law enforcement personnel and combat soldiers.

Genetic evidence for an East Asian origin of Chinese Muslim populations Dongxiang and Hui

PubMed Central

Yao, Hong-Bing; Wang, Chuan-Chao; Tao, Xiaolan; Shang, Lei; Wen, Shao-Qing; Zhu, Bofeng; Kang, Longli; Jin, Li; Li, Hui

2016-01-01

There is a long-going debate on the genetic origin of Chinese Muslim populations, such as Uygur, Dongxiang, and Hui. However, genetic information for those Muslim populations except Uygur is extremely limited. In this study, we investigated the genetic structure and ancestry of Chinese Muslims by analyzing 15 autosomal short tandem repeats in 652 individuals from Dongxiang, Hui, and Han Chinese populations in Gansu province. Both genetic distance and Bayesian-clustering methods showed significant genetic homogeneity between the two Muslim populations and East Asian populations, suggesting a common genetic ancestry. Our analysis found no evidence of substantial gene flow from Middle East or Europe into Dongxiang and Hui people during their Islamization. The dataset generated in present study are also valuable for forensic identification and paternity tests in China. PMID:27924949

Natural scene logo recognition by joint boosting feature selection in salient regions

NASA Astrophysics Data System (ADS)

Fan, Wei; Sun, Jun; Naoi, Satoshi; Minagawa, Akihiro; Hotta, Yoshinobu

2011-01-01

Logos are considered valuable intellectual properties and a key component of the goodwill of a business. In this paper, we propose a natural scene logo recognition method which is segmentation-free and capable of processing images extremely rapidly and achieving high recognition rates. The classifiers for each logo are trained jointly, rather than independently. In this way, common features can be shared across multiple classes for better generalization. To deal with large range of aspect ratio of different logos, a set of salient regions of interest (ROI) are extracted to describe each class. We ensure the selected ROIs to be both individually informative and two-by-two weakly dependant by a Class Conditional Entropy Maximization criteria. Experimental results on a large logo database demonstrate the effectiveness and efficiency of our proposed method.

Logit-normal mixed model for Indian Monsoon rainfall extremes

NASA Astrophysics Data System (ADS)

Dietz, L. R.; Chatterjee, S.

2014-03-01

Describing the nature and variability of Indian monsoon rainfall extremes is a topic of much debate in the current literature. We suggest the use of a generalized linear mixed model (GLMM), specifically, the logit-normal mixed model, to describe the underlying structure of this complex climatic event. Several GLMM algorithms are described and simulations are performed to vet these algorithms before applying them to the Indian precipitation data procured from the National Climatic Data Center. The logit-normal model was applied with fixed covariates of latitude, longitude, elevation, daily minimum and maximum temperatures with a random intercept by weather station. In general, the estimation methods concurred in their suggestion of a relationship between the El Niño Southern Oscillation (ENSO) and extreme rainfall variability estimates. This work provides a valuable starting point for extending GLMM to incorporate the intricate dependencies in extreme climate events.

Projected changes over western Canada using convection-permitting regional climate model and the pseudo-global warming method

NASA Astrophysics Data System (ADS)

Li, Y.; Kurkute, S.; Chen, L.

2017-12-01

Results from the General Circulation Models (GCMs) suggest more frequent and more severe extreme rain events in a climate warmer than the present. However, current GCMs cannot accurately simulate extreme rainfall events of short duration due to their coarse model resolutions and parameterizations. This limitation makes it difficult to provide the detailed quantitative information for the development of regional adaptation and mitigation strategies. Dynamical downscaling using nested Regional Climate Models (RCMs) are able to capture key regional and local climate processes with an affordable computational cost. Recent studies have demonstrated that the downscaling of GCM results with weather-permitting mesoscale models, such as the pseudo-global warming (PGW) technique, could be a viable and economical approach of obtaining valuable climate change information on regional scales. We have conducted a regional climate 4-km Weather Research and Forecast Model (WRF) simulation with one domain covering the whole western Canada, for a historic run (2000-2015) and a 15-year future run to 2100 and beyond with the PGW forcing. The 4-km resolution allows direct use of microphysics and resolves the convection explicitly, thus providing very convincing spatial detail. With this high-resolution simulation, we are able to study the convective mechanisms, specifically the control of convections over the Prairies, the projected changes of rainfall regimes, and the shift of the convective mechanisms in a warming climate, which has never been examined before numerically at such large scale with such high resolution.

Development of a hybrid microelectronics solid state relay for 2500 volts isolation and minus 120 C to 80 C thermal cycling range

NASA Technical Reports Server (NTRS)

Sater, B. L.; Riley, T. J.; Janssen, W.

1973-01-01

A hybrid microelectronics solid state relay was developed in a TO-116 package for the MINX project. The relay provides 2500 Vdc input to output isolation and operated from a MHTL logic signal to switch a load of 400 Vdc at 2 mA. The relay is designed to operate in space and survive 1000 thermal cycles of 120 C to 80 C. The use of X-rays for failure analysis in small hybrid circuits proved valuable and the applications of vacuum deposited Parylene as a dielectric coating proved extremely valuable.

Hidden values in bauxite residue (red mud): Recovery of metals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yanju; Naidu, Ravi, E-mail: ravi.naidu@unisa.edu.au

Highlights: • Current iron recovery techniques using red mud are depicted. • Advantages and disadvantages exist in different recovering processes. • Economic and environmental friendly integrated usage of red mud is promising. - Abstract: Bauxite residue (red mud) is a hazardous waste generated from alumina refining industries. Unless managed properly, red mud poses significant risks to the local environment due to its extreme alkalinity and its potential impacts on surface and ground water quality. The ever-increasing generation of red mud poses significant challenges to the aluminium industries from management perspectives given the low proportion that are currently being utilized beneficially.more » Red mud, in most cases, contains elevated concentrations of iron in addition to aluminium, titanium, sodium and valuable rare earth elements. Given the scarcity of iron supply globally, the iron content of red mud has attracted increasing research interest. This paper presents a critical overview of the current techniques employed for iron recovery from red mud. Information on the recovery of other valuable metals is also reviewed to provide an insight into the full potential usage of red mud as an economic resource rather than a waste. Traditional hydrometallurgy and pyrometallurgy are being investigated continuously. However, in this review several new techniques are introduced that consider the process of iron recovery from red mud. An integrated process which can achieve multiple additional values from red mud is much preferred over the single process methods. The information provided here should help to improve the future management and utilization of red mud.« less

Iterative and Event-Based Frameworks for University and School District Technology Professional Development Partnerships

ERIC Educational Resources Information Center

Winslow, Joseph; Dickerson, Jeremy; Weaver, Carmen; Josey, Fair

2016-01-01

Forming technology partnerships between universities and public schools in an era of competition and economic difficulty is a challenge. However, when these partnerships are formed and sustained, the benefits for both are extremely valuable. For a university instructional technology graduate program and school partnership to be successful, the…

Ten Time-Saving Tips for Undergraduate Research Mentors

ERIC Educational Resources Information Center

Coker, Jeffrey Scott; Davies, Eric

2006-01-01

Undergraduate research experiences can be extremely valuable for students, but can also be very time-consuming for mentors. A series of surveys were administered to plant biologists during the last 4 years to understand the perspectives of mentors on training undergraduate and high school student researchers. The survey responses provided a wealth…

Opinion Integration and Summarization

ERIC Educational Resources Information Center

Lu, Yue

2011-01-01

As Web 2.0 applications become increasingly popular, more and more people express their opinions on the Web in various ways in real time. Such wide coverage of topics and abundance of users make the Web an extremely valuable source for mining people's opinions about all kinds of topics. However, since the opinions are usually expressed as…

Production of Fatty Acid-Derived Valuable Chemicals in Synthetic Microbes

PubMed Central

Yu, Ai-Qun; Pratomo Juwono, Nina Kurniasih; Leong, Susanna Su Jan; Chang, Matthew Wook

2014-01-01

Fatty acid derivatives, such as hydroxy fatty acids, fatty alcohols, fatty acid methyl/ethyl esters, and fatty alka(e)nes, have a wide range of industrial applications including plastics, lubricants, and fuels. Currently, these chemicals are obtained mainly through chemical synthesis, which is complex and costly, and their availability from natural biological sources is extremely limited. Metabolic engineering of microorganisms has provided a platform for effective production of these valuable biochemicals. Notably, synthetic biology-based metabolic engineering strategies have been extensively applied to refactor microorganisms for improved biochemical production. Here, we reviewed: (i) the current status of metabolic engineering of microbes that produce fatty acid-derived valuable chemicals, and (ii) the recent progress of synthetic biology approaches that assist metabolic engineering, such as mRNA secondary structure engineering, sensor-regulator system, regulatable expression system, ultrasensitive input/output control system, and computer science-based design of complex gene circuits. Furthermore, key challenges and strategies were discussed. Finally, we concluded that synthetic biology provides useful metabolic engineering strategies for economically viable production of fatty acid-derived valuable chemicals in engineered microbes. PMID:25566540

Current and Emerging Technology Approaches in Genomics

PubMed Central

Conley, Yvette P.; Biesecker, Leslie G.; Gonsalves, Stephen; Merkle, Carrie J.; Kirk, Maggie; Aouizerat, Bradley E.

2013-01-01

Purpose To introduce current and emerging approaches that are being utilized in the field of genomics so the reader can conceptually evaluate the literature and appreciate how these approaches are advancing our understanding of health-related issues. Organizing Construct Each approach is described and includes information related to how it is advancing research, its potential clinical utility, exemplars of current uses, challenges related to technologies used for these approaches, and when appropriate information related to understanding the evidence base for clinical utilization of each approach is provided. Web-based resources are included for the reader who would like more in-depth information and to provide opportunity to stay up to date with these approaches and their utility. Conclusions The chosen approaches– genome sequencing, genome-wide association studies, epigenomics, and gene expression– are extremely valuable approaches for collecting research data to help us better understand the pathophysiology of a variety of health-related conditions, but they are also gaining in utility for clinical assessment and testing purposes. Clinical Relevance Our increased understanding of the molecular underpinnings of disease will assist with better development of screening tests, diagnostic tests, tests that allow us to prognosticate, tests that allow for individualized treatments, and tests to facilitate post-treatment surveillance. PMID:23294727

Unified approach for extrapolation and bridging of adult information in early-phase dose-finding paediatric studies.

PubMed

Petit, Caroline; Samson, Adeline; Morita, Satoshi; Ursino, Moreno; Guedj, Jérémie; Jullien, Vincent; Comets, Emmanuelle; Zohar, Sarah

2018-06-01

The number of trials conducted and the number of patients per trial are typically small in paediatric clinical studies. This is due to ethical constraints and the complexity of the medical process for treating children. While incorporating prior knowledge from adults may be extremely valuable, this must be done carefully. In this paper, we propose a unified method for designing and analysing dose-finding trials in paediatrics, while bridging information from adults. The dose-range is calculated under three extrapolation options, linear, allometry and maturation adjustment, using adult pharmacokinetic data. To do this, it is assumed that target exposures are the same in both populations. The working model and prior distribution parameters of the dose-toxicity and dose-efficacy relationships are obtained using early-phase adult toxicity and efficacy data at several dose levels. Priors are integrated into the dose-finding process through Bayesian model selection or adaptive priors. This calibrates the model to adjust for misspecification, if the adult and pediatric data are very different. We performed a simulation study which indicates that incorporating prior adult information in this way may improve dose selection in children.

The essential interactions between understanding climate variability and climate change

NASA Astrophysics Data System (ADS)

Neelin, J. D.

2017-12-01

Global change is sometimes perceived as a field separate from other aspects of atmospheric and oceanic sciences. Despite the long history of communication between the scientific communities studying global change and those studying interannual variability and weather, increasing specialization and conflicting societal demands on the fields can put these interactions at risk. At the same time, current trajectories for greenhouse gas emissions imply substantial adaptation to climate change will be necessary. Instead of simply projecting effects to be avoided, the field is increasingly being asked to provide regional-level information for specific adaptation strategies—with associated requirements for increased precision on projections. For extreme events, challenges include validating models for rare events, especially for events that are unprecedented in the historical record. These factors will be illustrated with examples of information transfer to climate change from work on fundamental climate processes aimed originally at timescales from hours to interannual. Work to understand the effects that control probability distributions of moisture, temperature and precipitation in historical weather can yield new factors to examine for the changes in the extremes of these distributions under climate change. Surprisingly simple process models can give insights into the behavior of vastly more complex climate models. Observation systems and model ensembles aimed at weather and interannual variations prove valuable for global change and vice versa. Work on teleconnections in the climate system, such as the remote impacts of El Niño, is informing analysis of projected regional rainfall change over California. Young scientists need to prepare to work across the full spectrum of climate variability and change, and to communicate their findings, as they and our society head for future that is more interesting than optimal.

Severity of vehicle bumper location in vehicle-to-pedestrian impact accidents.

PubMed

Matsui, Yasuhiro; Hitosugi, Masahito; Mizuno, Koji

2011-10-10

Pedestrian protection is one of the key topics for safety measures in traffic accidents all over the world. To analyze the relation between the collision site of the vehicle bumper and the severity of the lower extremity injuries, we performed biomechanical experiments. We compared the applied external force and the risks of subsequent injuries between the impact of the center and side positions of the front bumper. These comparisons were performed by practical impact tests with eight typical different types of cars which were typical of the current vehicle fleets. The tests were made using the TRL legform impactor which was a mechanical substitute of a pedestrian lower extremity. The TRL impactor is used all over the world for assessing the safety of car bumpers. It was found that the risks of lower extremity injuries in the impacts at the side positions, in front of the vehicle's side member, were significantly higher than those at the center. In the tests, we found that foam materials around the rigid front cross member had a significant effect on reducing the lower extremity injury risks and especially tibia fracture risk against vehicle bumper center collisions, but had little effect at the sides of the bumper over the vehicle's side members where the foam was thinner. We also found that the front shape of the vehicle affected the risk of ligaments injuries. According to these results, the information of impact locations of cars in vehicle-to-pedestrian traffic accidents is valuable for clinicians to diagnose patients with lower extremity injuries in traffic accidents and for forensic pathologists to analyze the accident reconstruction. Furthermore, the results suggest that testing of the bumper area in front of the main longitudinal beams should be included in the car safety legislation to require pedestrian safety. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Linking Teleconnections and Iowa's Climate

NASA Astrophysics Data System (ADS)

Rowe, S. T.; Villarini, G.; Lavers, D. A.; Scoccimarro, E.

2013-12-01

In recent years Iowa and the U.S. Midwest has experienced both extreme drought and flood periods. With a drought in 2012 bounded by major floods in 2011 and 2013, the rapid progression from one extreme to the next is on the forefront of the public mind. Given that Iowa is a major agricultural state, extreme weather conditions can have severe socioeconomic consequences. In this research we investigate the large-scale climate processes that occurred concurrently and before a range of dry/wet and cold/hot periods to improve process understanding of these events. It is essential to understand the large-scale climate processes, as these can then provide valuable insight toward the development of long-term climate forecasts for Iowa. In this study monthly and seasonal surface temperature and precipitation over 1950-2012 across Iowa are used. Precipitation and surface temperature data are retrieved from the Parameter-elevation Regressions on Independent Slopes Model (PRISM) Climate Group at Oregon State University. The large-scale atmospheric fields are obtained from the National Center for Environmental Prediction (NCEP) / National Center for Atmospheric Research (NCAR) Reanalysis 1 Project. Precipitation is stratified according to wet, normal, and dry conditions, while temperature according to hot, average, and cold periods. Different stratification criteria based on the precipitation and temperature distributions are examined. Mean sea-level pressure and sea-surface temperature composite maps for the northern hemisphere are then produced for the wet/dry conditions, and cold/hot conditions. Further analyses include correlation, anomalies, and assessment of large-scale planetary wave activity, shedding light on the differences and similarities among the opposite weather conditions. The results of this work will highlight regional weather patterns that are related to the climate over Iowa, providing valuable insight into the mechanisms controlling the occurrence of potentially extreme weather conditions over this area.

X-ray Reflectivity Study of a Highly Rough Surface: Si Nanowires Grown by Ag Nanoparticle Etching

NASA Astrophysics Data System (ADS)

Kremenak, Jesse; Arendse, Christopher; Cummings, Franscious; Chen, Yiyao; Miceli, Paul

Vertically oriented Si nanowires (SiNWs) formed by Ag-assisted wet chemical etching of a Si(100) substrate was studied by X-ray reflectivity (XRR) in combination with electron microscopy. Si(100) wafers coated with Ag nanoparticles, which serve as a catalyst, were etched for different durations in a HF/H2O2/DI-H2O solution. Because of the extreme roughness of these surfaces, there are challenges for using XRR methods in such systems. Therefore, significant attention is given to the analysis method of the XRR measurements. This sample-average information presents a valuable complement to electron microscopy studies, which focus on small sections of the sample. The present work shows-for the first time-the amount and distribution of Ag during the formation of SiNWs fabricated by Ag-assisted wet chemical etching, which is vital information for understanding the etching mechanisms. Support is gratefully acknowledged from the National Science Foundation (USA) - DGE1069091, the National Research Foundation (RSA) - TTK14052167658, 76568, 92520, and 93212; and the University of Missouri/University of Western Cape Linkage Program.

High speed ultra-broadband amplitude modulators with ultrahigh extinction >65 dB.

PubMed

Liu, S; Cai, H; DeRose, C T; Davids, P; Pomerene, A; Starbuck, A L; Trotter, D C; Camacho, R; Urayama, J; Lentine, A

2017-05-15

We experimentally demonstrate ultrahigh extinction ratio (>65 dB) amplitude modulators (AMs) that can be electrically tuned to operate across a broad spectral range of 160 nm from 1480 - 1640 nm and 95 nm from 1280 - 1375 nm. Our on-chip AMs employ one extra coupler compared with conventional Mach-Zehnder interferometers (MZI), thus form a cascaded MZI (CMZI) structure. Either directional or adiabatic couplers are used to compose the CMZI AMs and experimental comparisons are made between these two different structures. We investigate the performance of CMZI AMs under extreme conditions such as using 95:5 split ratio couplers and unbalanced waveguide losses. Electro-optic phase shifters are also integrated in the CMZI AMs for high-speed operation. Finally, we investigate the output optical phase when the amplitude is modulated, which provides us valuable information when both amplitude and phase are to be controlled. Our demonstration not only paves the road to applications such as quantum information processing that requires high extinction ratio AMs but also significantly alleviates the tight fabrication tolerance needed for large-scale integrated photonics.

Insect symbionts as valuable grist for the biotechnological mill: an alkaliphilic silkworm gut bacterium for efficient lactic acid production.

PubMed

Liang, Xili; Sun, Chao; Chen, Bosheng; Du, Kaiqian; Yu, Ting; Luang-In, Vijitra; Lu, Xingmeng; Shao, Yongqi

2018-06-01

Insects constitute the most abundant and diverse animal class and act as hosts to an extraordinary variety of symbiotic microorganisms. These microbes living inside the insects play critical roles in host biology and are also valuable bioresources. Enterococcus mundtii EMB156, isolated from the larval gut (gut pH >10) of the model organism Bombyx mori (Lepidoptera: Bombycidae), efficiently produces lactic acid, an important metabolite for industrial production of bioplastic materials. E. mundtii EMB156 grows well under alkaline conditions and stably converts various carbon sources into lactic acid, offering advantages in downstream fermentative processes. High-yield lactic acid production can be achieved by the strain EMB156 from renewable biomass substrates under alkaline pretreatments. Single-molecule real-time (SMRT) sequencing technology revealed its 3.01 Mbp whole genome sequence. A total of 2956 protein-coding sequences, 65 tRNA genes, and 6 rRNA operons were predicted in the EMB156 chromosome. Remarkable genomic features responsible for lactic acid fermentation included key enzymes involved in the pentose phosphate (PP)/glycolytic pathway, and an alpha amylase and xylose isomerase were characterized in EMB156. This genomic information coincides with the phenotype of E. mundtii EMB156, reflecting its metabolic flexibility in efficient lactate fermentation, and established a foundation for future biotechnological application. Interestingly, enzyme activities of amylase were quite stable in high-pH broths, indicating a possible mechanism for strong EMB156 growth in an alkaline environment, thereby facilitating lactic acid production. Together, these findings implied that valuable lactic acid-producing bacteria can be discovered efficiently by screening under the extremely alkaline conditions, as exemplified by gut microbial symbionts of Lepidoptera insects.

Geographic clustering of elderly people with above-norm anthropometric measurements and blood chemistry.

PubMed

Mena, Carlos; Fuentes, Eduardo; Ormazábal, Yony; Palomo, Iván

2017-05-11

The global percentage of people over 60 is strongly increasing and estimated to exceed 20% by 20,150, which means that there will be an increase in many pathological conditions related to aging. Mapping of the location of aging people and identification of their needs can be extremely valuable from a social-economic point of view. Participants in this study were 148 randomly selected adults from Talca City, Chile aged 60-74 at baseline. Geographic information systems (GIS) analyses were performed using ArcGIS software through its module Spatial Autocorrelation. In this study, we demonstrated that elderly people show geographic clustering according to above-norm results of anthropometric measurements and blood chemistry. The spatial identifications found would facilitate exploring the impact of treatment programmes in communities where many aging people live, thereby improving their quality of life as well as reducing overall costs.

Significance testing testate amoeba water table reconstructions

NASA Astrophysics Data System (ADS)

Payne, Richard J.; Babeshko, Kirill V.; van Bellen, Simon; Blackford, Jeffrey J.; Booth, Robert K.; Charman, Dan J.; Ellershaw, Megan R.; Gilbert, Daniel; Hughes, Paul D. M.; Jassey, Vincent E. J.; Lamentowicz, Łukasz; Lamentowicz, Mariusz; Malysheva, Elena A.; Mauquoy, Dmitri; Mazei, Yuri; Mitchell, Edward A. D.; Swindles, Graeme T.; Tsyganov, Andrey N.; Turner, T. Edward; Telford, Richard J.

2016-04-01

Transfer functions are valuable tools in palaeoecology, but their output may not always be meaningful. A recently-developed statistical test ('randomTF') offers the potential to distinguish among reconstructions which are more likely to be useful, and those less so. We applied this test to a large number of reconstructions of peatland water table depth based on testate amoebae. Contrary to our expectations, a substantial majority (25 of 30) of these reconstructions gave non-significant results (P > 0.05). The underlying reasons for this outcome are unclear. We found no significant correlation between randomTF P-value and transfer function performance, the properties of the training set and reconstruction, or measures of transfer function fit. These results give cause for concern but we believe it would be extremely premature to discount the results of non-significant reconstructions. We stress the need for more critical assessment of transfer function output, replication of results and ecologically-informed interpretation of palaeoecological data.

Stochastic sensitivity measure for mistuned high-performance turbines

NASA Technical Reports Server (NTRS)

Murthy, Durbha V.; Pierre, Christophe

1992-01-01

A stochastic measure of sensitivity is developed in order to predict the effects of small random blade mistuning on the dynamic aeroelastic response of turbomachinery blade assemblies. This sensitivity measure is based solely on the nominal system design (i.e., on tuned system information), which makes it extremely easy and inexpensive to calculate. The measure has the potential to become a valuable design tool that will enable designers to evaluate mistuning effects at a preliminary design stage and thus assess the need for a full mistuned rotor analysis. The predictive capability of the sensitivity measure is illustrated by examining the effects of mistuning on the aeroelastic modes of the first stage of the oxidizer turbopump in the Space Shuttle Main Engine. Results from a full analysis mistuned systems confirm that the simple stochastic sensitivity measure predicts consistently the drastic changes due to misturning and the localization of aeroelastic vibration to a few blades.

Insights into infectious disease in the era of Hippocrates.

PubMed

Pappas, Georgios; Kiriaze, Ismene J; Falagas, Matthew E

2008-07-01

Hippocrates is traditionally considered the father of modern medicine, still influencing, 25 centuries after his time, various aspects of medical practice and ethics. His collected works include various references to infectious diseases that range from general observations on the nature of infection, hygiene, epidemiology, and the immune response, to detailed descriptions of syndromes such as tuberculous spondylitis, malaria, and tetanus. We sought to evaluate the extent to which this historical information has influenced the modern relevant literature. Associating disease to the disequilibrium of body fluids may seem an ancient and outdated notion nowadays, but many of the clinical descriptions presented in the Corpus Hippocraticum (Hippocratic Collection) are still the archetypes of the natural history of certain infectious diseases and their collective interplay with the environment, climate, and society. For this reason, modern clinicians and researchers continue to be attracted to these 'lessons' from the past - lessons that remain extremely valuable.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nolan, W.E.; Block, S.

Dental roentgenograms are extremely valuable aids to the dentist. Their value must always be considered more important than the expense of a small local dose. However, where it is possible to reduce the exposure with negligible diagnostic sacrifice this must be done. It is strongly urged that corrective educational measures be provided. All accredited dental schools must have, as a required part of their curriculum a course in radiation protection or equivalent. This training could later be imparted to the dental technician. if necessary. In parallel with this act every manufacturer of x-ray machines must make it a point tomore » provide all the aforementioned adaptations on their new equipment. If possible all their past customers should be informed of the potential hazards of their machines and recommended corrections initiated. In any event there should be an enthusiastic drive toward putting an end to the needless excessive exposure given to the unwary public. (auth)« less

Response Functions for the Two-Dimensional Ultracold Fermi Gas: Dynamical BCS Theory and Beyond

NASA Astrophysics Data System (ADS)

Vitali, Ettore; Shi, Hao; Qin, Mingpu; Zhang, Shiwei

2017-12-01

Response functions are central objects in physics. They provide crucial information about the behavior of physical systems, and they can be directly compared with scattering experiments involving particles such as neutrons or photons. Calculations of such functions starting from the many-body Hamiltonian of a physical system are challenging and extremely valuable. In this paper, we focus on the two-dimensional (2D) ultracold Fermi atomic gas which has been realized experimentally. We present an application of the dynamical BCS theory to obtain response functions for different regimes of interaction strengths in the 2D gas with zero-range attractive interaction. We also discuss auxiliary-field quantum Monte Carlo (AFQMC) methods for the calculation of imaginary time correlations in these dilute Fermi gas systems. Illustrative results are given and comparisons are made between AFQMC and dynamical BCS theory results to assess the accuracy of the latter.

Risk assessment of precipitation extremes in northern Xinjiang, China

NASA Astrophysics Data System (ADS)

Yang, Jun; Pei, Ying; Zhang, Yanwei; Ge, Quansheng

2018-05-01

This study was conducted using daily precipitation records gathered at 37 meteorological stations in northern Xinjiang, China, from 1961 to 2010. We used the extreme value theory model, generalized extreme value (GEV) and generalized Pareto distribution (GPD), statistical distribution function to fit outputs of precipitation extremes with different return periods to estimate risks of precipitation extremes and diagnose aridity-humidity environmental variation and corresponding spatial patterns in northern Xinjiang. Spatiotemporal patterns of daily maximum precipitation showed that aridity-humidity conditions of northern Xinjiang could be well represented by the return periods of the precipitation data. Indices of daily maximum precipitation were effective in the prediction of floods in the study area. By analyzing future projections of daily maximum precipitation (2, 5, 10, 30, 50, and 100 years), we conclude that the flood risk will gradually increase in northern Xinjiang. GEV extreme value modeling yielded the best results, proving to be extremely valuable. Through example analysis for extreme precipitation models, the GEV statistical model was superior in terms of favorable analog extreme precipitation. The GPD model calculation results reflect annual precipitation. For most of the estimated sites' 2 and 5-year T for precipitation levels, GPD results were slightly greater than GEV results. The study found that extreme precipitation reaching a certain limit value level will cause a flood disaster. Therefore, predicting future extreme precipitation may aid warnings of flood disaster. A suitable policy concerning effective water resource management is thus urgently required.

Current knowledge and future research directions to link soil health and water conservation in the Ogallala Aquifer region.

USDA-ARS?s Scientific Manuscript database

The Ogallala Aquifer is one of the largest freshwater aquifers in the world. It acts as a valuable resource in agriculture, animal production, and public water supplies across eight Great Plains states. However, with high irrigation demand, low recharge rates across most of the region, and extreme c...

Draft Genome Sequence of a Sphingomonas sp., an Endosymbiotic Bacterium Isolated from an Arctic Lichen Umbilicaria sp.

PubMed Central

Lee, Jungeun; Shin, Seung Chul; Kim, Su Jin; Kim, Bum-Keun; Hong, Soon Gyu; Kim, Eun Hye; Park, Hyun

2012-01-01

Sphingomonas sp. strain PAMC 26617 has been isolated from an Arctic lichen Umbilicaria sp. on the Svalbard Islands. Here we present the draft genome sequence of this strain, which represents a valuable resource for understanding the symbiotic mechanisms between endosymbiotic bacteria and lichens surviving in extreme environments. PMID:22582371

Simple Assessment Techniques for Soil and Water. Environmental Factors in Small Scale Development Projects. Workshops.

ERIC Educational Resources Information Center

Coordination in Development, New York, NY.

This booklet was produced in response to the growing need for reliable environmental assessment techniques that can be applied to small-scale development projects. The suggested techniques emphasize low-technology environmental analysis. Although these techniques may lack precision, they can be extremely valuable in helping to assure the success…

Testing Students with Learning Disabilities. Assessment Brief. Number 6

ERIC Educational Resources Information Center

Dietel, Ron

2004-01-01

A variety of testing methods can be extremely useful in finding out whether children who are experiencing learning difficulties may have one or more learning disabilities. This is an important and valuable role for testing. Another important issue concerns how best to ensure fairness for a learning disabled student when he or she must take a…

Get a winning Oracle upgrade session using the quarterback approach

NASA Technical Reports Server (NTRS)

Anderson, G.

2002-01-01

Upgrades, upgrades... too much customer down time. Find out how we shrunk our production upgrade schedule 40% from our estimate of 10 days 12 hours to 6 days 2 hours using the quarterback approach. So your upgrade is not that complex, come anyway. This approach is scalable to any size project and will be extremely valuable.

OPTIMIZING THROUGH CO-EVOLUTIONARY AVALANCHES

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. BOETTCHER; A. PERCUS

2000-08-01

We explore a new general-purpose heuristic for finding high-quality solutions to hard optimization problems. The method, called extremal optimization, is inspired by ''self-organized critically,'' a concept introduced to describe emergent complexity in many physical systems. In contrast to Genetic Algorithms which operate on an entire ''gene-pool'' of possible solutions, extremal optimization successively replaces extremely undesirable elements of a sub-optimal solution with new, random ones. Large fluctuations, called ''avalanches,'' ensue that efficiently explore many local optima. Drawing upon models used to simulate far-from-equilibrium dynamics, extremal optimization complements approximation methods inspired by equilibrium statistical physics, such as simulated annealing. With only onemore » adjustable parameter, its performance has proved competitive with more elaborate methods, especially near phase transitions. Those phase transitions are found in the parameter space of most optimization problems, and have recently been conjectured to be the origin of some of the hardest instances in computational complexity. We will demonstrate how extremal optimization can be implemented for a variety of combinatorial optimization problems. We believe that extremal optimization will be a useful tool in the investigation of phase transitions in combinatorial optimization problems, hence valuable in elucidating the origin of computational complexity.« less

Relativistic frequency upshift to the extreme ultraviolet regime using self-induced oscillatory flying mirrors

PubMed Central

Kim, I Jong; Pae, Ki Hong; Kim, Chul Min; Kim, Hyung Taek; Yun, Hyeok; Yun, Sang Jae; Sung, Jae Hee; Lee, Seong Ku; Yoon, Jin Woo; Yu, Tae Jun; Jeong, Tae Moon; Nam, Chang Hee; Lee, Jongmin

2012-01-01

Coherent short-wavelength radiation from laser–plasma interactions is of increasing interest in disciplines including ultrafast biomolecular imaging and attosecond physics. Using solid targets instead of atomic gases could enable the generation of coherent extreme ultraviolet radiation with higher energy and more energetic photons. Here we present the generation of extreme ultraviolet radiation through coherent high-harmonic generation from self-induced oscillatory flying mirrors—a new-generation mechanism established in a long underdense plasma on a solid target. Using a 30-fs, 100-TW Ti:sapphire laser, we obtain wavelengths as short as 4.9 nm for an optimized level of amplified spontaneous emission. Particle-in-cell simulations show that oscillatory flying electron nanosheets form in a long underdense plasma, and suggest that the high-harmonic generation is caused by reflection of the laser pulse from electron nanosheets. We expect this extreme ultraviolet radiation to be valuable in realizing a compact X-ray instrument for research in biomolecular imaging and attosecond physics. PMID:23187631

The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophrenia.

PubMed

Durstewitz, Daniel; Seamans, Jeremy K

2008-11-01

There is now general consensus that at least some of the cognitive deficits in schizophrenia are related to dysfunctions in the prefrontal cortex (PFC) dopamine (DA) system. At the cellular and synaptic level, the effects of DA in PFC via D1- and D2-class receptors are highly complex, often apparently opposing, and hence difficult to understand with regard to their functional implications. Biophysically realistic computational models have provided valuable insights into how the effects of DA on PFC neurons and synaptic currents as measured in vitro link up to the neural network and cognitive levels. They suggest the existence of two discrete dynamical regimes, a D1-dominated state characterized by a high energy barrier among different network patterns that favors robust online maintenance of information and a D2-dominated state characterized by a low energy barrier that is beneficial for flexible and fast switching among representational states. These predictions are consistent with a variety of electrophysiological, neuroimaging, and behavioral results in humans and nonhuman species. Moreover, these biophysically based models predict that imbalanced D1:D2 receptor activation causing extremely low or extremely high energy barriers among activity states could lead to the emergence of cognitive, positive, and negative symptoms observed in schizophrenia. Thus, combined experimental and computational approaches hold the promise of allowing a detailed mechanistic understanding of how DA alters information processing in normal and pathological conditions, thereby potentially providing new routes for the development of pharmacological treatments for schizophrenia.

Is greater temperature change within a day associated with increased emergency admissions for schizophrenia?

PubMed

Zhao, Desheng; Zhang, Xulai; Xie, Mingyu; Cheng, Jian; Zhang, Heng; Wang, Shusi; Li, Kesheng; Yang, Huihui; Wen, Liying; Wang, Xu; Su, Hong

2016-10-01

Diurnal temperature range (DTR), as an important index of climate change, has been increasingly used to evaluate the impacts of temperature variability on human health. However, little is known about the effects of DTR on schizophrenia. The present study aims to examine the relationship between DTR and schizophrenia admissions, and further, to explore whether the association varied by individual characteristics and study periods. A Poisson generalized linear regression combined with distributed lag non-linear model (DLNM) was applied to analyze daily DTR and schizophrenia data from Hefei, China during 2005 to 2014, after adjusting for long-term and seasonal trends, mean temperature, relative humidity and other confounding factors. An acute adverse effect of extremely high DTR on schizophrenia was observed, with a 2.7% (95% CI: 1.007-1.047) increase of daily schizophrenia admissions after exposure to extremely high DTR (95th percentile vs. 50th percentile). The risk for schizophrenia onset due to large DTR exposure increased from the first five years (2005-2009) to the second five years (2010-2014). Additionally, the patient aged 15-29 and 50-64years, male patients, patients born in spring/autumn, and married patients appeared to be more vulnerable to DTR effect. However, there was no significant association between moderately high DTR (75th percentile) and schizophrenia. This study suggests that extremely high DTR is a potential trigger for schizophrenia admissions in Hefei, China. Our findings may provide valuable information to decisions-makers and guidance to health practitioners. Copyright © 2016 Elsevier B.V. All rights reserved.

Oral History and American Advertising: How the "Pepsi Generation" Came Alive.

ERIC Educational Resources Information Center

Dreyfus, Carol; Connors, Thomas

1985-01-01

Described is a project in which the Archives Center of the National Museum of American History and the George Meany Memorial Archives analyzed a collection of advertising materials of the Pepsi-Cola USA company and conducted interviews to gather historically valuable information concerning the company. Valuable social history information was…

The Importance of Visit Notes on Patient Portals for Engaging Less Educated or Nonwhite Patients: Survey Study

PubMed Central

Gerard, Macda; Chimowitz, Hannah; Fossa, Alan; Bourgeois, Fabienne; Fernandez, Leonor

2018-01-01

Background OpenNotes, a national initiative to share clinicians’ visit notes with patients, can improve patient engagement, but effects on vulnerable populations are not known very well. Objective Our aim is to examine the importance of visit notes to nonwhite and less educated patients. Methods Patients at an urban academic medical center with an active patient portal account and ≥1 available ambulatory visit note over the prior year were surveyed during June 2016 until September 2016. The survey was designed with patients and families and assessed importance of reading notes (scale 0-10) for (1) understanding health conditions, (2) feeling informed about care, (3) understanding the provider’s thought process, (4) remembering the plan of care, and (5) making decisions about care. We compared the proportion of patients reporting 9-10 (extremely important) for each item stratified by education level, race/ethnicity, and self-reported health. Principal component analysis and correlation measures supported a summary score for the 5 items (Cronbach alpha=.93). We examined factors associated with rating notes as extremely important to engage in care using logistic regression. Results Of 24,722 patients, 6913 (27.96%) completed the survey. The majority (6736/6913, 97.44%) read at least one note. Among note readers, 74.0% (727/982) of patients with ≤high school education, 70.7% (130/184) of black patients, and 69.9% (153/219) of Hispanic/Latino patients reported that notes are extremely important to feel informed about their care. The majority of less educated and nonwhite patients reported notes as extremely important to remember the care plan (62.4%, 613/982 ≤high school education; 62.0%, 114/184 black patients; and 61.6%, 135/219 Hispanic/Latino patients) and to make care decisions (62.3%, 612/982; 59.8%, 110/184; and 58.5%, 128/219, respectively, and P<.003 for all comparisons to more educated and white patients, respectively). Among patients with the poorest self-reported health, 65.9% (499/757) found notes extremely important to be informed and to understand the provider. On multivariable modeling, less educated patients were nearly three times as likely to report notes were extremely important to engage in care compared with the most educated patients (odds ratio [OR] 2.9, 95% CI 2.4-3.3). Nonwhite patients were twice as likely to report the same compared with white patients (OR 2.0, 95% CI 1.5-2.7 [black] and OR 2.2, 95% CI 1.6-2.9 [Hispanic/Latino and Asian], P<.001 for each comparison). Healthier patients, women, older patients, and those who read more notes were more likely to find notes extremely important to engage in care. Conclusions Less educated and nonwhite patients using the portal each assigned higher importance to reading notes for several health behaviors than highly educated and white patients, and may find transparent notes especially valuable for understanding their health and engaging in their care. Facilitating access to notes may improve engagement in health care for some vulnerable populations who have historically been more challenging to reach. PMID:29793900

Computer-aided psychotherapy based on multimodal elicitation, estimation and regulation of emotion.

PubMed

Cosić, Krešimir; Popović, Siniša; Horvat, Marko; Kukolja, Davor; Dropuljić, Branimir; Kovač, Bernard; Jakovljević, Miro

2013-09-01

Contemporary psychiatry is looking at affective sciences to understand human behavior, cognition and the mind in health and disease. Since it has been recognized that emotions have a pivotal role for the human mind, an ever increasing number of laboratories and research centers are interested in affective sciences, affective neuroscience, affective psychology and affective psychopathology. Therefore, this paper presents multidisciplinary research results of Laboratory for Interactive Simulation System at Faculty of Electrical Engineering and Computing, University of Zagreb in the stress resilience. Patient's distortion in emotional processing of multimodal input stimuli is predominantly consequence of his/her cognitive deficit which is result of their individual mental health disorders. These emotional distortions in patient's multimodal physiological, facial, acoustic, and linguistic features related to presented stimulation can be used as indicator of patient's mental illness. Real-time processing and analysis of patient's multimodal response related to annotated input stimuli is based on appropriate machine learning methods from computer science. Comprehensive longitudinal multimodal analysis of patient's emotion, mood, feelings, attention, motivation, decision-making, and working memory in synchronization with multimodal stimuli provides extremely valuable big database for data mining, machine learning and machine reasoning. Presented multimedia stimuli sequence includes personalized images, movies and sounds, as well as semantically congruent narratives. Simultaneously, with stimuli presentation patient provides subjective emotional ratings of presented stimuli in terms of subjective units of discomfort/distress, discrete emotions, or valence and arousal. These subjective emotional ratings of input stimuli and corresponding physiological, speech, and facial output features provides enough information for evaluation of patient's cognitive appraisal deficit. Aggregated real-time visualization of this information provides valuable assistance in patient mental state diagnostics enabling therapist deeper and broader insights into dynamics and progress of the psychotherapy.

Magnetic resonance techniques for investigation of multiple sclerosis

NASA Astrophysics Data System (ADS)

MacKay, Alex; Laule, Cornelia; Li, David K. B.; Meyers, Sandra M.; Russell-Schulz, Bretta; Vavasour, Irene M.

2014-11-01

Multiple sclerosis (MS) is a common neurological disease which can cause loss of vision and balance, muscle weakness, impaired speech, fatigue, cognitive dysfunction and even paralysis. The key pathological processes in MS are inflammation, edema, myelin loss, axonal loss and gliosis. Unfortunately, the cause of MS is still not understood and there is currently no cure. Magnetic resonance imaging (MRI) is an important clinical and research tool for MS. 'Conventional' MRI images of MS brain reveal bright lesions, or plaques, which demark regions of severe tissue damage. Conventional MRI has been extremely valuable for the diagnosis and management of people who have MS and also for the assessment of therapies designed to reduce inflammation and promote repair. While conventional MRI is clearly valuable, it lack pathological specificity and, in some cases, sensitivity to non-lesional pathology. Advanced MR techniques have been developed to provide information that is more sensitive and specific than what is available with clinical scanning. Diffusion tensor imaging and magnetization transfer provide a general but non-specific measure of the pathological state of brain tissue. MR spectroscopy provides concentrations of brain metabolites which can be related to specific pathologies. Myelin water imaging was designed to assess brain myelination and has proved useful for measuring myelin loss in MS. To combat MS, it is crucial that the pharmaceutical industry finds therapies which can reverse the neurodegenerative processes which occur in the disease. The challenge for magnetic resonance researchers is to design imaging techniques which can provide detailed pathological information relating to the mechanisms of MS therapies. This paper briefly describes the pathologies of MS and demonstrates how MS-associated pathologies can be followed using both conventional and advanced MR imaging protocols.

Assessing Secondary and College Students' Implicit Assumptions about the Particulate Nature of Matter: Development and Validation of the Structure and Motion of Matter Survey

ERIC Educational Resources Information Center

Stains, Marilyne; Escriu-Sune, Marta; Alverez de Santizo, Myrna Lisseth Molina; Sevian, Hannah

2011-01-01

Development of learning progressions has been at the forefront of science education for several years. While understanding students' conceptual development toward "big ideas" in science is extremely valuable for researchers, science teachers can also benefit from assessment tools that diagnose their students' trajectories along the learning…

Student Satisfaction Surveys: The Value in Taking an Historical Perspective

ERIC Educational Resources Information Center

Kane, David; Williams, James; Cappuccini-Ansfield, Gillian

2008-01-01

Benchmarking satisfaction over time can be extremely valuable where a consistent feedback cycle is employed. However, the value of benchmarking over a long period of time has not been analysed in depth. What is the value of benchmarking this type of data over time? What does it tell us about a feedback and action cycle? What impact does a study of…

What Is a Good Skeptic to Do? The Case for Skepticism in the Media Violence Discussion.

PubMed

Gentile, Douglas A

2015-09-01

The discussion about violent video games tends to engender extreme positions, each of which are deserving of deep skepticism. Ferguson's (2015, this issue) claim that humans can do something repeatedly with no effect on them should be examined carefully, especially as it violates most established psychological and learning theories. In this commentary, we examine three aspects of Ferguson's claim. First, it is a typical rhetorical trick to sow doubt, but it is valuable to examine the doubting claims. Second, it is good rhetoric to direct attention in only one direction, but it is valuable to examine that direction within its broader outlook. Third, it is good rhetoric to imply bias on the part of one position, but it is valuable to examine the potential biases on all sides. Good science definitely requires skeptics. The problem with the violent video game debate is perhaps that we have not been skeptical enough. © The Author(s) 2015.

Potential pitfalls of strain rate imaging: angle dependency

NASA Technical Reports Server (NTRS)

Castro, P. L.; Greenberg, N. L.; Drinko, J.; Garcia, M. J.; Thomas, J. D.

2000-01-01

Strain Rate Imaging (SRI) is a new echocardiographic technique that allows for the real-time determination of myocardial SR, which may be used for the early and accurate detection of coronary artery disease. We sought to study whether SR is affected by scan line alignment in a computer simulation and an in vivo experiment. Through the computer simulation and the in vivo experiment we generated and validated safe scanning sectors within the ultrasound scan sector and showed that while SRI will be an extremely valuable tool in detecting coronary artery disease there are potential pitfalls for the unwary clinician. Only after accounting for these affects due to angle dependency, can clinicians utilize SRI's potential as a valuable tool in detecting coronary artery disease.

Index for Predicting Insurance Claims from Wind Storms with an Application in France.

PubMed

Mornet, Alexandre; Opitz, Thomas; Luzi, Michel; Loisel, Stéphane

2015-11-01

For insurance companies, wind storms represent a main source of volatility, leading to potentially huge aggregated claim amounts. In this article, we compare different constructions of a storm index allowing us to assess the economic impact of storms on an insurance portfolio by exploiting information from historical wind speed data. Contrary to historical insurance portfolio data, meteorological variables show fewer nonstationarities between years and are easily available with long observation records; hence, they represent a valuable source of additional information for insurers if the relation between observations of claims and wind speeds can be revealed. Since standard correlation measures between raw wind speeds and insurance claims are weak, a storm index focusing on high wind speeds can afford better information. A storm index approach has been applied to yearly aggregated claim amounts in Germany with promising results. Using historical meteorological and insurance data, we assess the consistency of the proposed index constructions with respect to various parameters and weights. Moreover, we are able to place the major insurance events since 1998 on a broader horizon beyond 40 years. Our approach provides a meteorological justification for calculating the return periods of extreme-storm-related insurance events whose magnitude has rarely been reached. © 2015 Society for Risk Analysis.

Assessment of regional climate change and development of climate adaptation decision aids in the Southwestern US

NASA Astrophysics Data System (ADS)

Darmenova, K.; Higgins, G.; Kiley, H.; Apling, D.

2010-12-01

Current General Circulation Models (GCMs) provide a valuable estimate of both natural and anthropogenic climate changes and variability on global scales. At the same time, future climate projections calculated with GCMs are not of sufficient spatial resolution to address regional needs. Many climate impact models require information at scales of 50 km or less, so dynamical downscaling is often used to estimate the smaller-scale information based on larger scale GCM output. To address current deficiencies in local planning and decision making with respect to regional climate change, our research is focused on performing a dynamical downscaling with the Weather Research and Forecasting (WRF) model and developing decision aids that translate the regional climate data into actionable information for users. Our methodology involves development of climatological indices of extreme weather and heating/cooling degree days based on WRF ensemble runs initialized with the NCEP-NCAR reanalysis and the European Center/Hamburg Model (ECHAM5). Results indicate that the downscale simulations provide the necessary detailed output required by state and local governments and the private sector to develop climate adaptation plans. In addition we evaluated the WRF performance in long-term climate simulations over the Southwestern US and validated against observational datasets.

Obtaining parsimonious hydraulic conductivity fields using head and transport observations: A Bayesian geostatistical parameter estimation approach

NASA Astrophysics Data System (ADS)

Fienen, M.; Hunt, R.; Krabbenhoft, D.; Clemo, T.

2009-08-01

Flow path delineation is a valuable tool for interpreting the subsurface hydrogeochemical environment. Different types of data, such as groundwater flow and transport, inform different aspects of hydrogeologic parameter values (hydraulic conductivity in this case) which, in turn, determine flow paths. This work combines flow and transport information to estimate a unified set of hydrogeologic parameters using the Bayesian geostatistical inverse approach. Parameter flexibility is allowed by using a highly parameterized approach with the level of complexity informed by the data. Despite the effort to adhere to the ideal of minimal a priori structure imposed on the problem, extreme contrasts in parameters can result in the need to censor correlation across hydrostratigraphic bounding surfaces. These partitions segregate parameters into facies associations. With an iterative approach in which partitions are based on inspection of initial estimates, flow path interpretation is progressively refined through the inclusion of more types of data. Head observations, stable oxygen isotopes (18O/16O ratios), and tritium are all used to progressively refine flow path delineation on an isthmus between two lakes in the Trout Lake watershed, northern Wisconsin, United States. Despite allowing significant parameter freedom by estimating many distributed parameter values, a smooth field is obtained.

Obtaining parsimonious hydraulic conductivity fields using head and transport observations: A Bayesian geostatistical parameter estimation approach

USGS Publications Warehouse

Fienen, M.; Hunt, R.; Krabbenhoft, D.; Clemo, T.

2009-01-01

Flow path delineation is a valuable tool for interpreting the subsurface hydrogeochemical environment. Different types of data, such as groundwater flow and transport, inform different aspects of hydrogeologic parameter values (hydraulic conductivity in this case) which, in turn, determine flow paths. This work combines flow and transport information to estimate a unified set of hydrogeologic parameters using the Bayesian geostatistical inverse approach. Parameter flexibility is allowed by using a highly parameterized approach with the level of complexity informed by the data. Despite the effort to adhere to the ideal of minimal a priori structure imposed on the problem, extreme contrasts in parameters can result in the need to censor correlation across hydrostratigraphic bounding surfaces. These partitions segregate parameters into facies associations. With an iterative approach in which partitions are based on inspection of initial estimates, flow path interpretation is progressively refined through the inclusion of more types of data. Head observations, stable oxygen isotopes (18O/16O ratios), and tritium are all used to progressively refine flow path delineation on an isthmus between two lakes in the Trout Lake watershed, northern Wisconsin, United States. Despite allowing significant parameter freedom by estimating many distributed parameter values, a smooth field is obtained.

Perspectives on biotechnological applications of archaea

PubMed Central

Schiraldi, Chiara; Giuliano, Mariateresa; De Rosa, Mario

2002-01-01

Many archaea colonize extreme environments. They include hyperthermophiles, sulfur-metabolizing thermophiles, extreme halophiles and methanogens. Because extremophilic microorganisms have unusual properties, they are a potentially valuable resource in the development of novel biotechnological processes. Despite extensive research, however, there are few existing industrial applications of either archaeal biomass or archaeal enzymes. This review summarizes current knowledge about the biotechnological uses of archaea and archaeal enzymes with special attention to potential applications that are the subject of current experimental evaluation. Topics covered include cultivation methods, recent achievements in genomics, which are of key importance for the development of new biotechnological tools, and the application of wild-type biomasses, engineered microorganisms, enzymes and specific metabolites in particular bioprocesses of industrial interest. PMID:15803645

Perspectives on biotechnological applications of archaea.

PubMed

Schiraldi, Chiara; Giuliano, Mariateresa; De Rosa, Mario

2002-09-01

Many archaea colonize extreme environments. They include hyperthermophiles, sulfur-metabolizing thermophiles, extreme halophiles and methanogens. Because extremophilic microorganisms have unusual properties, they are a potentially valuable resource in the development of novel biotechnological processes. Despite extensive research, however, there are few existing industrial applications of either archaeal biomass or archaeal enzymes. This review summarizes current knowledge about the biotechnological uses of archaea and archaeal enzymes with special attention to potential applications that are the subject of current experimental evaluation. Topics covered include cultivation methods, recent achievements in genomics, which are of key importance for the development of new biotechnological tools, and the application of wild-type biomasses, engineered microorganisms, enzymes and specific metabolites in particular bioprocesses of industrial interest.

Tree grades, yields and values for some Appalachian hardwoods

Treesearch

Robert A. Campbell

1951-01-01

Foresters ahve long recognized the need for a better method of appraising standing timber in terms of quality as well as volume of lumber that trees may be expected to produce. Because the range in price between high-grade lumber and low-grade lumber is extremely wide, a stand of high-quality timber is much more valuable than a low-quality stand. In spite of this,...

Changing stand structure and regional growth reductions in Georgia's natural pine stands: discussion paper response

Treesearch

W.A. Bechtold; G.A. Ruark; F.T. Lloyd

1991-01-01

This paper was submitted for discussion in the expectation that the discussion format would allow maximum coverage of the many issues associated with the valuation of temporal growth patterns over extensive geographic areas. To this end, the input from the discussants and numerous other reviewers has been extremely valuable, and we are sincerely grateful for their many...

Sex Pheromone of Conophthorus ponderosae (Coleoptera: Scolytidae) in a Coastal Stand of Western White Pine (Pinaceae)

Treesearch

Daniel R. Miller; Harold D. Pierce; Peter de Groot; Nicole Jeans-Williams; Robb Bennett; John H. Borden

2000-01-01

An isolated stand of western white pine, Pinus monticola Dougl. ex D. Don, on Texada Island (49°40'N, 124°10'W), British Columbia, is extremely valuable as a seed-production area for progeny resistant to white pine blister rust, Cronartium ribicola J.C. Fisch. (Cronartiaceae). During the past 5 years, cone beetles, ...

A Foundation for Understanding Knowledge Sharing: Organizational Culture, Informal Workplace Learning, Performance Support, and Knowledge Management

ERIC Educational Resources Information Center

Caruso, Shirley J.

2017-01-01

This paper serves as an exploration into some of the ways in which organizations can promote, capture, share, and manage the valuable knowledge of their employees. The problem is that employees typically do not share valuable information, skills, or expertise with other employees or with the entire organization. The author uses research as well as…

Beneficial effects of restoration practices can be thwarted by climate extremes.

PubMed

Maccherini, Simona; Bacaro, Giovanni; Marignani, Michela

2018-06-01

The impacts of climate extremes on species, communities and ecosystems have become critical concerns to science and society. Under a changing climate, how restoration outcomes are affected by extreme climate variables is a largely unknown topic. We analyzed the effects of experimental factors (grazing and sowing of native species), extreme climate events (intense precipitation and extreme temperatures indexes) and their combination on the restoration progress of a dry, calcareous grassland in Tuscany (Italy) with a 1 year before/15 years continuous annual monitoring after, control/impact (BACI) experiment. Grazing had a beneficial effect on the diversity of the grassland, while sowing had a limited impact. The climatic index that most affected the entire plant community composition was the number of very heavy precipitation days. The interaction of grazing and extreme climatic indexes had a significant detrimental effect on restoration outcomes, increasing the cover of synanthropic and Cosmopolitan-Subcosmopolitan generalist species and decreasing the cover of more valuable species such endemic species. In the richest grazed plots, species richness showed a lower sensitivity to the average precipitation per wet day but in grazed site, restoration outcomes can be negatively influenced by the intensification of precipitation and temperature extremes. In a context of progressive tropicalization of the Mediterranean area, to assist managers setting achievable restoration goals, restoration practitioners should consider that climate extremes might interfere with the beneficial effects of restoration practices. Copyright © 2018 Elsevier B.V. All rights reserved.

High speed ultra-broadband amplitude modulators with ultrahigh extinction >65 dB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, S.; Cai, H.; DeRose, C. T.

Here, we experimentally demonstrate ultrahigh extinction ratio (>65 dB) amplitude modulators (AMs) that can be electrically tuned to operate across a broad spectral range of 160 nm from 1480 – 1640 nm and 95 nm from 1280 – 1375 nm. Our on-chip AMs employ one extra coupler compared with conventional Mach-Zehnder interferometers (MZI), thus form a cascaded MZI (CMZI) structure. Either directional or adiabatic couplers are used to compose the CMZI AMs and experimental comparisons are made between these two different structures. Furthermore, we investigate the performance of CMZI AMs under extreme conditions such as using 95:5 split ratio couplersmore » and unbalanced waveguide losses. Electro-optic phase shifters are also integrated in the CMZI AMs for high-speed operation. Finally, we investigate the output optical phase when the amplitude is modulated, which provides us valuable information when both amplitude and phase are to be controlled. This demonstration not only paves the road to applications such as quantum information processing that requires high extinction ratio AMs but also significantly alleviates the tight fabrication tolerance needed for large-scale integrated photonics.« less

High speed ultra-broadband amplitude modulators with ultrahigh extinction >65 dB

DOE PAGES

Liu, S.; Cai, H.; DeRose, C. T.; ...

2017-05-04

Here, we experimentally demonstrate ultrahigh extinction ratio (>65 dB) amplitude modulators (AMs) that can be electrically tuned to operate across a broad spectral range of 160 nm from 1480 – 1640 nm and 95 nm from 1280 – 1375 nm. Our on-chip AMs employ one extra coupler compared with conventional Mach-Zehnder interferometers (MZI), thus form a cascaded MZI (CMZI) structure. Either directional or adiabatic couplers are used to compose the CMZI AMs and experimental comparisons are made between these two different structures. Furthermore, we investigate the performance of CMZI AMs under extreme conditions such as using 95:5 split ratio couplersmore » and unbalanced waveguide losses. Electro-optic phase shifters are also integrated in the CMZI AMs for high-speed operation. Finally, we investigate the output optical phase when the amplitude is modulated, which provides us valuable information when both amplitude and phase are to be controlled. This demonstration not only paves the road to applications such as quantum information processing that requires high extinction ratio AMs but also significantly alleviates the tight fabrication tolerance needed for large-scale integrated photonics.« less

Knowledge discovery through games and game theory

NASA Astrophysics Data System (ADS)

Smith, James F., III; Rhyne, Robert D.

2001-03-01

A fuzzy logic based expert system has been developed that automatically allocates electronic attack (EA) resources in real-time over many dissimilar platforms. The platforms can be very general, e.g., ships, planes, robots, land based facilities, etc. Potential foes the platforms deal with can also be general. The initial version of the algorithm was optimized using a genetic algorithm employing fitness functions constructed based on expertise. A new approach is being explored that involves embedding the resource manager in a electronic game environment. The game allows a human expert to play against the resource manager in a simulated battlespace with each of the defending platforms being exclusively directed by the fuzzy resource manager and the attacking platforms being controlled by the human expert or operating autonomously under their own logic. This approach automates the data mining problem. The game automatically creates a database reflecting the domain expert's knowledge, it calls a data mining function, a genetic algorithm, for data mining of the database as required. The game allows easy evaluation of the information mined in the second step. The measure of effectiveness (MOE) for re-optimization is discussed. The mined information is extremely valuable as shown through demanding scenarios.

Psychophysical experiments on the PicHunter image retrieval system

NASA Astrophysics Data System (ADS)

Papathomas, Thomas V.; Cox, Ingemar J.; Yianilos, Peter N.; Miller, Matt L.; Minka, Thomas P.; Conway, Tiffany E.; Ghosn, Joumana

2001-01-01

Psychophysical experiments were conducted on PicHunter, a content-based image retrieval (CBIR) experimental prototype with the following properties: (1) Based on a model of how users respond, it uses Bayes's rule to predict what target users want, given their actions. (2) It possesses an extremely simple user interface. (3) It employs an entropy- based scheme to improve convergence. (4) It introduces a paradigm for assessing the performance of CBIR systems. Experiments 1-3 studied human judgment of image similarity to obtain data for the model. Experiment 4 studied the importance of using: (a) semantic information, (b) memory of earlier input, and (c) relative and absolute judgments of similarity. Experiment 5 tested an approach that we propose for comparing performances of CBIR systems objectively. Finally, experiment 6 evaluated the most informative display-updating scheme that is based on entropy minimization, and confirmed earlier simulation results. These experiments represent one of the first attempts to quantify CBIR performance based on psychophysical studies, and they provide valuable data for improving CBIR algorithms. Even though they were designed with PicHunter in mind, their results can be applied to any CBIR system and, more generally, to any system that involves judgment of image similarity by humans.

Comparative Variable Temperature Studies of Polyamide II with a Benchtop Fourier Transform and a Miniature Handheld Near-Infrared Spectrometer Using 2D-COS and PCMW-2D Analysis.

PubMed

Unger, Miriam; Pfeifer, Frank; Siesler, Heinz W

2016-07-01

The main objective of this communication is to compare the performance of a miniaturized handheld near-infrared (NIR) spectrometer with a benchtop Fourier transform near-infrared (FT-NIR) spectrometer. Generally, NIR spectroscopy is an extremely powerful analytical tool to study hydrogen-bonding changes of amide functionalities in solid and liquid materials and therefore variable temperature NIR measurements of polyamide II (PAII) have been selected as a case study. The information content of the measurement data has been further enhanced by exploiting the potential of two-dimensional correlation spectroscopy (2D-COS) and the perturbation correlation moving window two-dimensional (PCMW2D) evaluation technique. The data provide valuable insights not only into the changes of the hydrogen-bonding structure and the recrystallization of the hydrocarbon segments of the investigated PAII but also in their sequential order. Furthermore, it has been demonstrated that the 2D-COS and PCMW2D results derived from the spectra measured with the miniaturized NIR instrument are equivalent to the information extracted from the data obtained with the high-performance FT-NIR instrument. © The Author(s) 2016.

Clinical application of metabolomics in neonatology.

PubMed

Fanos, Vassilios; Antonucci, Roberto; Barberini, Luigi; Noto, Antonio; Atzori, Luigi

2012-04-01

The youngest and more rapidly increasing "omic" discipline, called metabolomics, is the process of describing the phenotype of a cell, tissue or organism through the full complement of metabolites present. Metabolomics measure global sets of low molecular weight metabolites (including amino acids, organic acids, sugars, fatty acids, lipids, steroids, small peptides, vitamins, etc.), thus providing a "snapshot" of the metabolic status of a cell, tissue or organism in relation to genetic variations or external stimuli. The use of metabolomics appears to be a promising tool in neonatology. The management of sick newborns might improve if more information on perinatal/neonatal maturational processes and their metabolic background were available. Urine ("a window on the organism") is a biofluid particularly suitable for metabolomic analysis in neonatology because it may be collected by using simple, noninvasive techniques and because it may provide valuable diagnostic information. In this review, the authors report the few literature data on neonatal metabolomics, including their personal experience, in the following fields: intrauterine growth restriction, perinatal transition, asphyxia, brain injury and hypothermia, maternal milk evaluation, postnatal maturation, bronchiolitis, sepsis, patent ductus arteriosus, respiratory distress syndrome, nephrouropathies, metabolic diseases, antibiotic treatment, perinatal programming and long-term outcome in extremely low birth-weight infants.

A Fast Monte Carlo Simulation for the International Linear Collider Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furse, D.; /Georgia Tech

2005-12-15

The following paper contains details concerning the motivation for, implementation and performance of a Java-based fast Monte Carlo simulation for a detector designed to be used in the International Linear Collider. This simulation, presently included in the SLAC ILC group's org.lcsim package, reads in standard model or SUSY events in STDHEP file format, stochastically simulates the blurring in physics measurements caused by intrinsic detector error, and writes out an LCIO format file containing a set of final particles statistically similar to those that would have found by a full Monte Carlo simulation. In addition to the reconstructed particles themselves, descriptionsmore » of the calorimeter hit clusters and tracks that these particles would have produced are also included in the LCIO output. These output files can then be put through various analysis codes in order to characterize the effectiveness of a hypothetical detector at extracting relevant physical information about an event. Such a tool is extremely useful in preliminary detector research and development, as full simulations are extremely cumbersome and taxing on processor resources; a fast, efficient Monte Carlo can facilitate and even make possible detector physics studies that would be very impractical with the full simulation by sacrificing what is in many cases inappropriate attention to detail for valuable gains in time required for results.« less

Making an Impact: Stories with Data, Tips, and Lessons Learned from Collaborating With and Across Communities

NASA Astrophysics Data System (ADS)

Drapkin, J. K.; Ramamurthy, P.; Vant-Hull, B.; Mazumdar, S.; Glenn, A.; Jusino, C.; Corbin, C.; Brooke, H.; Keefe, J.; Schuerman, M.

2016-12-01

Those most at risk during heat waves and floods - are often the socio-economically vulnerable. Yet very few studies exist of indoor temperatures during heat waves or of standing water events at the neighborhood level during extreme events. ISeeChange, a community weather and climate journal, is developing tools and testing techniques in a series of community pilots in Harlem and New Orleans to assess if a combination of citizen science and journalism can bridge the gap. Our consortium of media (WNYC,Adapt NYC, ISeeChange), scientists (CUNY, CoCoRaHS, NASAJPL), and community partners (WE ACT for Environmental Justice, tenant, and neighborhood associations) are collaborating to engage with residents, report radio stories, as well as develop scientifically valuable information for decision-making. Community volunteers place temperature and humidity sensors inside residences (Harlem) or photograph standing water using specific methodologies (New Orleans). Sensor data, photographs, and text documenting the impacts of extreme weather on residents are posted on the ISeeChange platform via mobile app or community ambassadors. Preliminary results of the Harlem pilot show that indoor temperatures are far more stable than outdoor temperatures, so can be both cooler during the day but warmer at night; preliminary work on the New Orleans pilot is set to begin in fall 2016. A full analysis of the Harlem pilot will be presented along with preliminary results of the New Orleans pilot.

Lessons from a Space Analog on Adaptation for Long-Duration Exploration Missions.

PubMed

Anglin, Katlin M; Kring, Jason P

2016-04-01

Exploration missions to asteroids and Mars will bring new challenges associated with communication delays and more autonomy for crews. Mission safety and success will rely on how well the entire system, from technology to the human elements, is adaptable and resilient to disruptive, novel, or potentially catastrophic events. The recent NASA Extreme Environment Missions Operations (NEEMO) 20 mission highlighted this need and produced valuable "lessons learned" that will inform future research on team adaptation and resilience. A team of NASA, industry, and academic members used an iterative process to design a tripod shaped structure, called the CORAL Tower, for two astronauts to assemble underwater with minimal tools. The team also developed assembly procedures, administered training to the crew, and provided support during the mission. During the design, training, and assembly of the Tower, the team learned first-hand how adaptation in extreme environments depends on incremental testing, thorough procedures and contingency plans that predict possible failure scenarios, and effective team adaptation and resiliency for the crew and support personnel. Findings from NEEMO 20 provide direction on the design and testing process for future space systems and crews to maximize adaptation. This experience also underscored the need for more research on team adaptation, particularly how input and process factors affect adaption outcomes, the team adaptation iterative process, and new ways to measure the adaptation process.

Application of short-data methods on extreme surge levels

NASA Astrophysics Data System (ADS)

Feng, X.

2014-12-01

Tropical cyclone-induced storm surges are among the most destructive natural hazards that impact the United States. Unfortunately for academic research, the available time series for extreme surge analysis are very short. The limited data introduces uncertainty and affects the accuracy of statistical analyses of extreme surge levels. This study deals with techniques applicable to data sets less than 20 years, including simulation modelling and methods based on the parameters of the parent distribution. The verified water levels from water gauges spread along the Southwest and Southeast Florida Coast, as well as the Florida Keys, are used in this study. Methods to calculate extreme storm surges are described and reviewed, including 'classical' methods based on the generalized extreme value (GEV) distribution and the generalized Pareto distribution (GPD), and approaches designed specifically to deal with short data sets. Incorporating global-warming influence, the statistical analysis reveals enhanced extreme surge magnitudes and frequencies during warm years, while reduced levels of extreme surge activity are observed in the same study domain during cold years. Furthermore, a non-stationary GEV distribution is applied to predict the extreme surge levels with warming sea surface temperatures. The non-stationary GEV distribution indicates that with 1 Celsius degree warming in sea surface temperature from the baseline climate, the 100-year return surge level in Southwest and Southeast Florida will increase by up to 40 centimeters. The considered statistical approaches for extreme surge estimation based on short data sets will be valuable to coastal stakeholders, including urban planners, emergency managers, and the hurricane and storm surge forecasting and warning system.

Replicating research in ecology and evolution: feasibility, incentives, and the cost-benefit conundrum.

PubMed

Nakagawa, Shinichi; Parker, Timothy H

2015-10-28

We believe that replicating studies in ecology and evolution is extremely valuable, but replication within species and systems is troublingly rare, and even 'quasi-replications' in different systems are often insufficient. We make a case for supporting multiple types of replications and point out that the current incentive structure needs to change if ecologists and evolutionary biologist are to value scientific replication sufficiently.

Using FIA data to assess current and potential future tree species importance values in the eastern United States

Treesearch

Louis Iverson; Anantha Prasad; Anantha Prasad

2003-01-01

FIA data are extremely valuable for evaluating regional variation in forest distribution. We have processed and summarized FIA data to show four patterns across the Eastern United States: 1) the number and density of FIA forested plots by state, 2) current importance values and frequencies for several species within 20 x 20 km blocks, 3) tree diversity by block, and 4...

Using FIA data to assess current and potential future tree species importance values in the eastern United States

Treesearch

Louis Iverson; Anantha Prasad

2002-01-01

FIA data are extremely valuable for evaluating regional variation in forest distribution. We have processed and summarized FIA data to show four patterns across the Eastern United States: 1) the number and density of FIA forested plots by state, 2) current importance values and frequencies for several species within 20 x 20 km blocks, 3) tree diversity by block, and 4...

Preventing academic difficulties in preterm children: a randomised controlled trial of an adaptive working memory training intervention - IMPRINT study.

PubMed

Pascoe, Leona; Roberts, Gehan; Doyle, Lex W; Lee, Katherine J; Thompson, Deanne K; Seal, Marc L; Josev, Elisha K; Nosarti, Chiara; Gathercole, Susan; Anderson, Peter J

2013-09-16

Very preterm children exhibit difficulties in working memory, a key cognitive ability vital to learning information and the development of academic skills. Previous research suggests that an adaptive working memory training intervention (Cogmed) may improve working memory and other cognitive and behavioural domains, although further randomised controlled trials employing long-term outcomes are needed, and with populations at risk for working memory deficits, such as children born preterm.In a cohort of extremely preterm (<28 weeks' gestation)/extremely low birthweight (<1000 g) 7-year-olds, we will assess the effectiveness of Cogmed in improving academic functioning 2 years' post-intervention. Secondary objectives are to assess the effectiveness of Cogmed in improving working memory and attention 2 weeks', 12 months' and 24 months' post-intervention, and to investigate training related neuroplasticity in working memory neural networks 2 weeks' post-intervention. This double-blind, placebo-controlled, randomised controlled trial aims to recruit 126 extremely preterm/extremely low birthweight 7-year-old children. Children attending mainstream school without major intellectual, sensory or physical impairments will be eligible. Participating children will undergo an extensive baseline cognitive assessment before being randomised to either an adaptive or placebo (non-adaptive) version of Cogmed. Cogmed is a computerised working memory training program consisting of 25 sessions completed over a 5 to 7 week period. Each training session takes approximately 35 minutes and will be completed in the child's home. Structural, diffusion and functional Magnetic Resonance Imaging, which is optional for participants, will be completed prior to and 2 weeks following the training period. Follow-up assessments focusing on academic skills (primary outcome), working memory and attention (secondary outcomes) will be conducted at 2 weeks', 12 months' and 24 months' post-intervention. To our knowledge, this study will be the first randomised controlled trial to (a) assess the effectiveness of Cogmed in school-aged extremely preterm/extremely low birthweight children, while incorporating advanced imaging techniques to investigate neural changes associated with adaptive working memory training, and (b) employ long-term follow-up to assess the potential benefit of improved working memory on academic functioning. If effective, Cogmed would serve as a valuable, available intervention for improving developmental outcomes for this population. Australian New Zealand Clinical Trials Registry ACTRN12612000124831.

Mitochondria in anthropology and forensic medicine.

PubMed

Grzybowski, Tomasz; Rogalla, Urszula

2012-01-01

Mitochondria's role in crucial metabolic pathways is probably the first answer which comes to our minds for the question: what do these tiny organelles serve for? However, specific features of their DNA made them extremely useful also in the field of anthropology and forensics. MtDNA analyses became a milestone in the complex task of unraveling earliest human migrations. Evidence provided by these experiments left no doubts on modern humans origins pointing to Africa being our cradle. It also contributed to interpretation of putative ways of our dispersal around Asia and Americas thousands years ago. On the other hand, analysis of mtDNA is well established and valuable tool in forensic genetics. When other definitely more popular markers give no answer on identity, it is the time to employ information carried by mitochondria. This chapter summarizes not only current reports on the role of mitochondria in forensics and reconstruction of modern humans phylogeny, but also calls one's attention to a broad range of difficulties and constraints associated with mtDNA analyses.

Lymphangiography

PubMed Central

Kadin, Michael R.; Thompson, Ronald W.

1974-01-01

Since the introduction of “staging laparotomy” (to determine the disease's stage) in assessing Hodgkin's disease, some observers have argued that lymphangiography could be safely omitted in the initial diagnostic evaluation. To test these opinions a series of 75 patients with Hodgkin's disease who had a staging laparotomy and histological correlation with lymphangiograms was reviewed. Of 16 examinations with positive results, one proved to be a false positive. Of the 14 examinations with equivocal results, one proved histologically positive. In the remaining 45 lymphangiograms, five were falsely negative. In all five of these patients abdominal lymph nodes were involved, but in areas that do not routinely opacify on lower extremity lymphangiography. The overall accuracy was 90 percent. Therapeutically, the lymphangiogram permits accurate planning for treatment by radiation therapy so that all known disease is treated and yet bone marrow is not excessively irradiated. Changes in lymph node architecture after therapy provide valuable information as to regression of the disease or signs of its early recurrence. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7. PMID:4816398

Specific adsorption of cadmium on surface-engineered biocompatible organoclay under metal-phenanthrene mixed-contamination.

PubMed

Biswas, Bhabananda; Sarkar, Binoy; Mandal, Asit; Naidu, Ravi

2016-11-01

Bioremediation of polycyclic aromatic hydrocarbons (PAHs) is extremely challenging when they coexist with heavy metals. This constrain has led to adsorption-based techniques that help immobilize the metals and reduce toxicity. However, the adsorbents can also non-selectively bind the organic compounds, which reduces their bioavailability. In this study we developed a surface-engineered organoclay (Arquad ® 2HT-75-bentonite-palmitic acid) which enhanced bacterial proliferation and adsorbed cadmium, but elevated phenanthrene bioavailability. Adsorption models of single and binary solutes revealed that the raw bentonite adsorbed cadmium and phenanthrene non-selectively at the same binding sites and sequestrated phenanthrene. In contrast, cadmium selectively bound to the deprotonated state of carboxyl groups in the organoclay and phenanthrene on the outer surface of the adsorbent led to a microbially congenial microenvironment with a higher phenanthrene bioavailability. This study provided valuable information which would be highly important for developing a novel clay-modulated bioremediation technology for cleaning up PAHs under mixed-contaminated situations. Copyright © 2016 Elsevier Ltd. All rights reserved.

A New Paradigm in Earth Environmental Monitoring with the CYGNSS Small Satellite Constellation

NASA Technical Reports Server (NTRS)

Ruf, C. S.; Chew, C.; Lang, T.; Morris, M. G.; Kyle, K.; Ridley, A.; Balasubramaniam, R.

2018-01-01

A constellation of small, low-cost satellites is able to make scientifically valuable measurements of the Earth which can be used for weather forecasting, disaster monitoring, and climate studies. Eight CYGNSS satellites were launched into low Earth orbit on December 15, 2016. Each satellite carries a science radar receiver which measures GPS signals reflected from the Earth surface. The signals contain information about the surface, including wind speed over ocean and soil moisture and flooding over land. The satellites are distributed around the globe so that measurements can be made more often to capture extreme weather events. Innovative engineering approaches are used to reduce per satellite cost, increase the number in the constellation, and improve temporal sampling. These include the use of differential drag rather than propulsion to adjust the spacing between satellites and the use of existing GPS signals as the science radars’ transmitter. Initial on-orbit results demonstrate the scientific utility of the CYGNSS observations, and suggest that a new paradigm in spaceborne Earth environmental monitoring is possible.

New Mars meteorite fall in Morocco: collecting observations and determining the spatial distribution in the strewnfield

NASA Astrophysics Data System (ADS)

Ibhi, Abderrahmane

2013-01-01

The existence of Martian meteorites in the region of Tissint (Tata, Morocco) dropped by a very bright fireball on July 18, 2011, had been notified to a group of scientists of the Ibn Zohr University of Agadir, Morocco, at the beginning of January 2012, by a nomad of Tata who had found a small fragment in the region. As soon as a scientific expedition arrived at the place of the meteorite fall, the members of the laboratory of Geo-heritage and Geo-materials Science started gathering information and collecting the debris of this Martian meteorite. The Tissint fireball has been observed and reported by numerous witnesses across the southeastern Morocco. The event was extremely valuable to the scientific community: it was the brightest and most comprehensively observed fireball in Morocco's known astronomical history. We are now in a position to draw the distribution ellipse of the fall, which starts at Jbel Al Gallab and continues in east-southeastern direction, above big rocky plateaus.

The Updated Multiple Star Catalog

NASA Astrophysics Data System (ADS)

Tokovinin, Andrei

2018-03-01

The catalog of hierarchical stellar systems with three or more components is an update of the original 1997 version. For 2000 hierarchies, the new Multiple Star Catalog (MSC) provides distances, component masses and periods, and supplementary information (astrometry, photometry, identifiers, orbits, notes). The MSC content and format are explained, and its incompleteness and strong observational selection are stressed. Nevertheless, the MSC can be used for statistical studies and is a valuable source for planning observations of multiple stars. Rare classes of stellar hierarchies found in the MSC (with six or seven components, extremely eccentric orbits, planar and possibly resonant orbits, hosting planets) are briefly presented. High-order hierarchies have smaller velocity dispersion compared to triples and are often associated with moving groups. The paper concludes with an analysis of the ratio of periods and separations between inner and outer subsystems. In wide hierarchies, the ratio of semimajor axes, estimated statistically, is distributed between 3 and 300, with no evidence of dynamically unstable systems.

Phase correlation imaging of unlabeled cell dynamics

NASA Astrophysics Data System (ADS)

Ma, Lihong; Rajshekhar, Gannavarpu; Wang, Ru; Bhaduri, Basanta; Sridharan, Shamira; Mir, Mustafa; Chakraborty, Arindam; Iyer, Rajashekar; Prasanth, Supriya; Millet, Larry; Gillette, Martha U.; Popescu, Gabriel

2016-09-01

We present phase correlation imaging (PCI) as a novel approach to study cell dynamics in a spatially-resolved manner. PCI relies on quantitative phase imaging time-lapse data and, as such, functions in label-free mode, without the limitations associated with exogenous markers. The correlation time map outputted in PCI informs on the dynamics of the intracellular mass transport. Specifically, we show that PCI can extract quantitatively the diffusion coefficient map associated with live cells, as well as standard Brownian particles. Due to its high sensitivity to mass transport, PCI can be applied to studying the integrity of actin polymerization dynamics. Our results indicate that the cyto-D treatment blocking the actin polymerization has a dominant effect at the large spatial scales, in the region surrounding the cell. We found that PCI can distinguish between senescent and quiescent cells, which is extremely difficult without using specific markers currently. We anticipate that PCI will be used alongside established, fluorescence-based techniques to enable valuable new studies of cell function.

Arcjet Testing of Micro-Meteoroid Impacted Thermal Protection Materials

NASA Technical Reports Server (NTRS)

Agrawal, Parul; Munk, Michelle M.; Glaab, Louis J.

2013-01-01

There are several harsh space environments that could affect thermal protection systems and in turn pose risks to the atmospheric entry vehicles. These environments include micrometeoroid impact, extreme cold temperatures, and ionizing radiation during deep space cruise, all followed by atmospheric entry heating. To mitigate these risks, different thermal protection material samples were subjected to multiple tests, including hyper velocity impact, cold soak, irradiation, and arcjet testing, at various NASA facilities that simulated these environments. The materials included a variety of honeycomb packed ablative materials as well as carbon-based non-ablative thermal protection systems. The present paper describes the results of the multiple test campaign with a focus on arcjet testing of thermal protection materials. The tests showed promising results for ablative materials. However, the carbon-based non-ablative system presented some concerns regarding the potential risks to an entry vehicle. This study provides valuable information regarding the capability of various thermal protection materials to withstand harsh space environments, which is critical to sample return and planetary entry missions.

Structural Framework for Flight: NASA's Role in Development of Advanced Composite Materials for Aircraft and Space Structures

NASA Technical Reports Server (NTRS)

Tenney, Darrel R.; Davis, John G., Jr.; Johnston, Norman J.; Pipes, R. Byron; McGuire, Jack F.

2011-01-01

This serves as a source of collated information on Composite Research over the past four decades at NASA Langley Research Center, and is a key reference for readers wishing to grasp the underlying principles and challenges associated with developing and applying advanced composite materials to new aerospace vehicle concepts. Second, it identifies the major obstacles encountered in developing and applying composites on advanced flight vehicles, as well as lessons learned in overcoming these obstacles. Third, it points out current barriers and challenges to further application of composites on future vehicles. This is extremely valuable for steering research in the future, when new breakthroughs in materials or processing science may eliminate/minimize some of the barriers that have traditionally blocked the expanded application of composite to new structural or revolutionary vehicle concepts. Finally, a review of past work and identification of future challenges will hopefully inspire new research opportunities and development of revolutionary materials and structural concepts to revolutionize future flight vehicles.

Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.

PubMed

Meloche, S; Beatty, B G; Pellerin, J

1996-10-03

We report the cloning and characterization of a human cDNA encoding a novel homolog of rat extracellular signal-regulated kinase 3 (ERK3). The cDNA encodes a predicted protein of 721 amino acids which shares 92% amino acid identity with rat ERK3 over their shared length. Interestingly, the human protein contains a unique extension of 178 amino acids at its carboxy terminal extremity. The human ERK3 protein also displays various degrees of homology to other members of the MAP kinases family, but does not contain the typical TXY regulatory motif between subdomains VII and VIII. Northern blot analysis revealed that ERK3 mRNA is widely distributed in human tissues, with the highest expression detected in skeletal muscle. The human ERK3 gene was mapped by fluorescence in situ hybridization to chromosome 15q21, a region associated with chromosomal abnormalities in acute nonlymphoblastic leukemias. This information should prove valuable in designing studies to define the cellular function of the ERK3 protein kinase.

Bottom-up perspectives of extreme event and climate change threats to water quality: Drinking water utilities in California

NASA Astrophysics Data System (ADS)

Ekstrom, J.; Klasic, M.; Fencl, A.; Lubell, M.; Bedsworth, L. W.; Baker, E.

2016-12-01

Extreme events impact water quality, which pose serious challenges for drinking water systems. Such extreme events, including wildfire, storm surge, and other weather-related extremes, are projected to increase under a changing climate. It remains unclear what climate change information can support water managers in preparing for more extreme events. Exploring this topic requires understanding the larger question: What is the role of scientific information in adapting to climate change? We present two parts of a three-year study geared to understand whether, where, why and in what way climate information (or the lack of) is used or needed to support long term water quality planning for extreme events. In 2015 we surveyed California drinking water utilities and found a wide range of extreme event/water quality issues, perspectives on the severity of climate change threats, drought impacts and trusted information sources relating to water quality concerns. Approximately 70% of 259 respondents had recently experienced extreme weather-related events that worsen or trigger water quality. Survey results informed development of a case study analysis to gain a more in-depth understanding of what type of - or when - extreme events information could support climate adaptation. Projections of extreme events are often not in a form that is useable for water quality planning. Relative to supply-related projections, water quality has received much less scientific attention, leaving it an assumed scientific information gap and need for management. The question remains whether filling this gap would help adaptation, whom it would help, and in what way. Based on interviews with water systems in Summer 2016, our case study analyses reinforce that extreme events threaten water quality in many ways; largely as secondary impacts of climate change. Secondary impacts involve disinfection byproducts, increasing salinity in the Delta, and the use of lower quality sources. The most common barriers impeding effective adaptation were not related to information. Instead, respondents frequently expressed the obstacles of external institutions not coordinating with their needs. This demonstrates why climate adaptation must simultaneously occur at multiple levels of governance in order for water systems to successfully advance.

Extreme precipitation depths for Texas, excluding the Trans-Pecos region

USGS Publications Warehouse

Lanning-Rush, Jennifer; Asquith, William H.; Slade, Raymond M.

1998-01-01

Storm durations of 1, 2, 3, 4, 5, and 6 days were investigated for this report. The extreme precipitation depth for a particular area is estimated from an “extreme precipitation curve” (an upper limit or envelope curve developed from graphs of extreme precipitation depths for each climatic region). The extreme precipitation curves were determined using precipitation depth-duration information from a subset (24 “extreme” storms) of 213 “notable” storms documented throughout Texas. The extreme precipitation curves can be used to estimate extreme precipitation depth for a particular area. The extreme precipitation depth represents a limiting depth, which can provide useful comparative information for more quantitative analyses.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Ai-Qun; Pratomo Juwono, Nina Kurniasih; Synthetic Biology Research Program, National University of Singapore, Singapore

Fatty acid derivatives, such as hydroxy fatty acids, fatty alcohols, fatty acid methyl/ethyl esters, and fatty alka(e)nes, have a wide range of industrial applications including plastics, lubricants, and fuels. Currently, these chemicals are obtained mainly through chemical synthesis, which is complex and costly, and their availability from natural biological sources is extremely limited. Metabolic engineering of microorganisms has provided a platform for effective production of these valuable biochemicals. Notably, synthetic biology-based metabolic engineering strategies have been extensively applied to refactor microorganisms for improved biochemical production. Here, we reviewed: (i) the current status of metabolic engineering of microbes that produce fattymore » acid-derived valuable chemicals, and (ii) the recent progress of synthetic biology approaches that assist metabolic engineering, such as mRNA secondary structure engineering, sensor-regulator system, regulatable expression system, ultrasensitive input/output control system, and computer science-based design of complex gene circuits. Furthermore, key challenges and strategies were discussed. Finally, we concluded that synthetic biology provides useful metabolic engineering strategies for economically viable production of fatty acid-derived valuable chemicals in engineered microbes.« less

Highly Thermal Conductive Nanocomposites

NASA Technical Reports Server (NTRS)

Sun, Ya-Ping (Inventor); Connell, John W. (Inventor); Veca, Lucia Monica (Inventor)

2015-01-01

Disclosed are methods for forming carbon-based fillers as may be utilized in forming highly thermal conductive nanocomposite materials. Formation methods include treatment of an expanded graphite with an alcohol/water mixture followed by further exfoliation of the graphite to form extremely thin carbon nanosheets that are on the order of between about 2 and about 10 nanometers in thickness. Disclosed carbon nanosheets can be functionalized and/or can be incorporated in nanocomposites with extremely high thermal conductivities. Disclosed methods and materials can prove highly valuable in many technological applications including, for instance, in formation of heat management materials for protective clothing and as may be useful in space exploration or in others that require efficient yet light-weight and flexible thermal management solutions.

Highly Thermal Conductive Nanocomposites

NASA Technical Reports Server (NTRS)

Sun, Ya-Ping (Inventor); Connell, John W. (Inventor); Veca, Lucia Monica (Inventor)

2017-01-01

Disclosed are methods for forming carbon-based fillers as may be utilized in forming highly thermal conductive nanocomposite materials. Formation methods include treatment of an expanded graphite with an alcohol/water mixture followed by further exfoliation of the graphite to form extremely thin carbon nanosheets that are on the order of between about 2 and about 10 nanometers in thickness. Disclosed carbon nanosheets can be functionalized and/or can be incorporated in nanocomposites with extremely high thermal conductivities. Disclosed methods and materials can prove highly valuable in many technological applications including, for instance, in formation of heat management materials for protective clothing and as may be useful in space exploration or in others that require efficient yet light-weight and flexible thermal management solutions.

The quality of visual information about the lower extremities influences visuomotor coordination during virtual obstacle negotiation.

PubMed

Kim, Aram; Kretch, Kari S; Zhou, Zixuan; Finley, James M

2018-05-09

Successful negotiation of obstacles during walking relies on the integration of visual information about the environment with ongoing locomotor commands. When information about the body and environment are removed through occlusion of the lower visual field, individuals increase downward head pitch angle, reduce foot placement precision, and increase safety margins during crossing. However, whether these effects are mediated by loss of visual information about the lower extremities, the obstacle, or both remains to be seen. Here, we used a fully immersive, virtual obstacle negotiation task to investigate how visual information about the lower extremities is integrated with information about the environment to facilitate skillful obstacle negotiation. Participants stepped over virtual obstacles while walking on a treadmill with one of three types of visual feedback about the lower extremities: no feedback, end-point feedback, or a link-segment model. We found that absence of visual information about the lower extremities led to an increase in the variability of leading foot placement after crossing. The presence of a visual representation of the lower extremities promoted greater downward head pitch angle during the approach to and subsequent crossing of an obstacle. In addition, having greater downward head pitch was associated with closer placement of the trailing foot to the obstacle, further placement of the leading foot after the obstacle, and higher trailing foot clearance. These results demonstrate that the fidelity of visual information about the lower extremities influences both feed-forward and feedback aspects of visuomotor coordination during obstacle negotiation.

Mapping Extreme Heat Vulnerability and Health Outcomes to inform the District of Columbia's Climate Adaptation Plan

NASA Astrophysics Data System (ADS)

Declet-Barreto, J.; Wilhelmi, O.; Goggans, A.

2016-12-01

In this collaborative engagement, scientists are partnering with the District of Columbia (DC) to develop an extreme heat vulnerability assessment. To do so, we map socio-demographic and built environment indicators of extreme heat vulnerability in Census Tracts in DC neighborhoods. In order to provide information useful for DC public health and urban planning practitioners, we aggregate the indicators into an index of extreme heat vulnerability. We compare the index against heat-related call data from DC's 911 system to better understand the socio-spatial distribution of extreme heat-related health outcomes. Our assessment can help inform the District's Climate Adaptation Plan as well as increase public engagement in reducing vulnerability to extreme heat.

Field trial of the enhanced data authentication system (EDAS)

DOE PAGES

Thomas, Maikael A.; Hymel, Ross W.; Baldwin, George; ...

2016-11-01

The Enhanced Data Authentication System (EDAS) is means to securely branch information from an existing measurement system or data stream to a secondary observer. In an international nuclear safeguards context, the EDAS connects to operator instrumentation, and provides a cryptographically secure copy of the information for a safeguards inspectorate. However, this novel capability could be a valuable complement to inspector-owned safeguards instrumentation, offering context that is valuable for anomaly resolution and contingency.

Selectively Distracted: Divided Attention and Memory for Important Information.

PubMed

Middlebrooks, Catherine D; Kerr, Tyson; Castel, Alan D

2017-08-01

Distractions and multitasking are generally detrimental to learning and memory. Nevertheless, people often study while listening to music, sitting in noisy coffee shops, or intermittently checking their e-mail. The current experiments examined how distractions and divided attention influence one's ability to selectively remember valuable information. Participants studied lists of words that ranged in value from 1 to 10 points while completing a digit-detection task, while listening to music, or without distractions. Though participants recalled fewer words following digit detection than in the other conditions, there were no significant differences between conditions in terms of selectively remembering the most valuable words. Similar results were obtained across a variety of divided-attention tasks that stressed attention and working memory to different degrees, which suggests that people may compensate for divided-attention costs by selectively attending to the most valuable items and that factors that worsen memory do not necessarily impair the ability to selectively remember important information.

Medicare: Better Controls Needed for Peer Review Organizations’ Evaluations.

DTIC Science & Technology

1987-10-01

reflected significant uncertainties (percent of cases reviewed and cost per case). The national funding model utilized to develop the Goverrnent estimates...differences. As GAO stated, HCFA’s funding model was based on data from HCFA’s actuary, the Departnent of Labor, professional medical associations and... funding model extremely valuable in negotiating PRO contracts. The conclusion reached by GAO that the overall average cost contracted per review was less

Final Report: Air Purification: Nanostructured Media for Individual Protection

DTIC Science & Technology

2016-06-27

conventional adsorbents such as zeolites and activated carbon. Since that first article in 2012, we published a series of papers on water adsorption in a...of conventional adsorbents such as zeolites and activated carbons. This work will be extremely valuable for both the MOF community and the broader...adsorbents such as activated carbons and zeolites . The objective of this portion of work in this area has been to develop an engineered material that is

The Spacecraft Materials Selector: An Artificial Intelligence System for Preliminary Design Trade Studies, Materials Assessments, and Estimates of Environments Present

NASA Technical Reports Server (NTRS)

Pippin, H. G.; Woll, S. L. B.

2000-01-01

Institutions need ways to retain valuable information even as experienced individuals leave an organization. Modern electronic systems have enough capacity to retain large quantities of information that can mitigate the loss of experience. Performance information for long-term space applications is relatively scarce and specific information (typically held by a few individuals within a single project) is often rather narrowly distributed. Spacecraft operate under severe conditions and the consequences of hardware and/or system failures, in terms of cost, loss of information, and time required to replace the loss, are extreme. These risk factors place a premium on appropriate choice of materials and components for space applications. An expert system is a very cost-effective method for sharing valuable and scarce information about spacecraft performance. Boeing has an artificial intelligence software package, called the Boeing Expert System Tool (BEST), to construct and operate knowledge bases to selectively recall and distribute information about specific subjects. A specific knowledge base to evaluate the on-orbit performance of selected materials on spacecraft has been developed under contract to the NASA SEE program. The performance capabilities of the Spacecraft Materials Selector (SMS) knowledge base are described. The knowledge base is a backward-chaining, rule-based system. The user answers a sequence of questions, and the expert system provides estimates of optical and mechanical performance of selected materials under specific environmental conditions. The initial operating capability of the system will include data for Kapton, silverized Teflon, selected paints, silicone-based materials, and certain metals. For situations where a mission profile (launch date, orbital parameters, mission duration, spacecraft orientation) is not precisely defined, the knowledge base still attempts to provide qualitative observations about materials performance and likely exposures. Prior to the NASA contract, a knowledge base, the Spacecraft Environments Assistant (SEA,) was initially developed by Boeing to estimate the environmental factors important for a specific spacecraft mission profile. The NASA SEE program has funded specific enhancements to the capability of this knowledge base. The SEA qualitatively identifies over 25 environmental factors that may influence the performance of a spacecraft during its operational lifetime. For cases where sufficiently detailed answers are provided to questions asked by the knowledge base, atomic oxygen fluence levels, proton and/or electron fluence and dose levels, and solar exposure hours are calculated. The SMS knowledge base incorporates the previously developed SEA knowledge base. A case history for previous flight experiment will be shown as an example, and capabilities and limitations of the system will be discussed.

Atmospheric rivers and past hydrometeorological extremes: Challenges and opportunities

NASA Astrophysics Data System (ADS)

Sodemann, Harald

2017-04-01

Atmospheric rivers are a key term for describing water vapour transport in extratropical regions. The concept has become particularly valuable for linking meteorological process understanding with research focused on the impacts of heavy precipitation. Atmospheric rivers are narrow, elongated features of high integrated water vapour and water vapour flux can lead to severe precipitation and flooding if moisture is extracted efficiently. The orographic rises at the West Coast of the United States and Western Norway are regions where Atmospheric Rivers are one of the prime mechanisms for moisture delivery and precipitation extremes in the present climate. Due to the small horizontal scales of some of the processes climate models are challenged to represent this important transport process between mid-latitudes and the subtropics faithfully. Recent aircraft data and regional tracer model studies provide new insight into the formation and moisture transport mechanisms. In this study I review the concept and pertinent processes of Atmospheric Rivers, thereby focusing on caveats, challenges and opportunities for understanding past hydrometeorological extremes.

Genomics and Metagenomics of Extreme Acidophiles in Biomining Environments

NASA Astrophysics Data System (ADS)

Holmes, D. S.

2015-12-01

Over 160 draft or complete genomes of extreme acidophiles (pH < 3) have been published, many of which are from bioleaching and other biomining environments, or are closely related to such microorganisms. In addition, there are over 20 metagenomic studies of such environments. This provides a rich source of latent data that can be exploited for understanding the biology of biomining environments and for advancing biotechnological applications. Genomic and metagenomic data are already yielding valuable insights into cellular processes, including carbon and nitrogen management, heavy metal and acid resistance, iron and sulfur oxido-reduction, linking biogeochemical processes to organismal physiology. The data also allow the construction of useful models of the ecophysiology of biomining environments and provide insight into the gene and genome evolution of extreme acidophiles. Additionally, since most of these acidophiles are also chemoautolithotrophs that use minerals as energy sources or electron sinks, their genomes can be plundered for clues about the evolution of cellular metabolism and bioenergetic pathways during the Archaean abiotic/biotic transition on early Earth. Acknowledgements: Fondecyt 1130683.

Social and content aware One-Class recommendation of papers in scientific social networks.

PubMed

Wang, Gang; He, XiRan; Ishuga, Carolyne Isigi

2017-01-01

With the rapid development of information technology, scientific social networks (SSNs) have become the fastest and most convenient way for researchers to communicate with each other. Many published papers are shared via SSNs every day, resulting in the problem of information overload. How to appropriately recommend personalized and highly valuable papers for researchers is becoming more urgent. However, when recommending papers in SSNs, only a small amount of positive instances are available, leaving a vast amount of unlabelled data, in which negative instances and potential unseen positive instances are mixed together, which naturally belongs to One-Class Collaborative Filtering (OCCF) problem. Therefore, considering the extreme data imbalance and data sparsity of this OCCF problem, a hybrid approach of Social and Content aware One-class Recommendation of Papers in SSNs, termed SCORP, is proposed in this study. Unlike previous approaches recommended to address the OCCF problem, social information, which has been proved playing a significant role in performing recommendations in many domains, is applied in both the profiling of content-based filtering and the collaborative filtering to achieve superior recommendations. To verify the effectiveness of the proposed SCORP approach, a real-life dataset from CiteULike was employed. The experimental results demonstrate that the proposed approach is superior to all of the compared approaches, thus providing a more effective method for recommending papers in SSNs.

Social and content aware One-Class recommendation of papers in scientific social networks

PubMed Central

Wang, Gang; He, XiRan

2017-01-01

With the rapid development of information technology, scientific social networks (SSNs) have become the fastest and most convenient way for researchers to communicate with each other. Many published papers are shared via SSNs every day, resulting in the problem of information overload. How to appropriately recommend personalized and highly valuable papers for researchers is becoming more urgent. However, when recommending papers in SSNs, only a small amount of positive instances are available, leaving a vast amount of unlabelled data, in which negative instances and potential unseen positive instances are mixed together, which naturally belongs to One-Class Collaborative Filtering (OCCF) problem. Therefore, considering the extreme data imbalance and data sparsity of this OCCF problem, a hybrid approach of Social and Content aware One-class Recommendation of Papers in SSNs, termed SCORP, is proposed in this study. Unlike previous approaches recommended to address the OCCF problem, social information, which has been proved playing a significant role in performing recommendations in many domains, is applied in both the profiling of content-based filtering and the collaborative filtering to achieve superior recommendations. To verify the effectiveness of the proposed SCORP approach, a real-life dataset from CiteULike was employed. The experimental results demonstrate that the proposed approach is superior to all of the compared approaches, thus providing a more effective method for recommending papers in SSNs. PMID:28771495

Review: Diversity of Microorganisms in Global Fermented Foods and Beverages

PubMed Central

Tamang, Jyoti P.; Watanabe, Koichi; Holzapfel, Wilhelm H.

2016-01-01

Culturalable and non-culturable microorganisms naturally ferment majority of global fermented foods and beverages. Traditional food fermentation represents an extremely valuable cultural heritage in most regions, and harbors a huge genetic potential of valuable but hitherto undiscovered strains. Holistic approaches for identification and complete profiling of both culturalable and non-culturable microorganisms in global fermented foods are of interest to food microbiologists. The application of culture-independent technique has thrown new light on the diversity of a number of hitherto unknown and non-cultural microorganisms in naturally fermented foods. Functional bacterial groups (“phylotypes”) may be reflected by their mRNA expression in a particular substrate and not by mere DNA-level detection. An attempt has been made to review the microbiology of some fermented foods and alcoholic beverages of the world. PMID:27047484

HISTORICAL ANALYSIS, A VALUABLE TOOL IN COMMUNITY-BASED ENVIRONMENTAL PROTECTION

EPA Science Inventory

A historical analysis of the ecological consequences of development can be a valuable tool in community-based environmental protection. These studies can engage the public in environmental issues and lead to informed decision making. Historical studies provide an understanding of...

Water shortages and extreme events: a call for research.

PubMed

Carmichael, Catriona; Odams, Sue; Murray, Virginia; Sellick, Matthew; Colbourne, Jeni

2013-09-01

Water shortages as a result of extreme weather events, such as flooding and severe cold, have the potential to affect significant numbers of people. Therefore, the need to build robust, coordinated plans based on scientific evidence is crucial. The literature review outlined in this short communication was conducted as part of a joint Drinking Water Inspectorate and Health Protection Agency (now Public Health England) report which aimed to review the scientific evidence base on extreme events, water shortages and the resulting health impacts. A systematic literature review was undertaken to identify published literature from both peer-reviewed and grey literature sources. The retrieved literature was then assessed using the Scottish Intercollegiate Guidelines Network quality assessment. The authors found very few scientific studies. However, a great deal of valuable grey literature was retrieved and used by the research team. In total, six main themes of importance that were identified by the review and discussed included health impacts, water quantity and quality, alternative supplies, vulnerable groups, communication with those affected and the emergency response. The authors conclude that more research needs to be conducted on health impacts and extreme events water shortages in order to build the future knowledge base and development of resilience.

Local-scale changes in mean and heavy precipitation in Western Europe, climate change or internal variability?

NASA Astrophysics Data System (ADS)

Aalbers, Emma E.; Lenderink, Geert; van Meijgaard, Erik; van den Hurk, Bart J. J. M.

2018-06-01

High-resolution climate information provided by e.g. regional climate models (RCMs) is valuable for exploring the changing weather under global warming, and assessing the local impact of climate change. While there is generally more confidence in the representativeness of simulated processes at higher resolutions, internal variability of the climate system—`noise', intrinsic to the chaotic nature of atmospheric and oceanic processes—is larger at smaller spatial scales as well, limiting the predictability of the climate signal. To quantify the internal variability and robustly estimate the climate signal, large initial-condition ensembles of climate simulations conducted with a single model provide essential information. We analyze a regional downscaling of a 16-member initial-condition ensemble over western Europe and the Alps at 0.11° resolution, similar to the highest resolution EURO-CORDEX simulations. We examine the strength of the forced climate response (signal) in mean and extreme daily precipitation with respect to noise due to internal variability, and find robust small-scale geographical features in the forced response, indicating regional differences in changes in the probability of events. However, individual ensemble members provide only limited information on the forced climate response, even for high levels of global warming. Although the results are based on a single RCM-GCM chain, we believe that they have general value in providing insight in the fraction of the uncertainty in high-resolution climate information that is irreducible, and can assist in the correct interpretation of fine-scale information in multi-model ensembles in terms of a forced response and noise due to internal variability.

A navigation system for the visually impaired an intelligent white cane.

PubMed

Fukasawa, A Jin; Magatani, Kazusihge

2012-01-01

In this paper, we describe about a developed navigation system that supports the independent walking of the visually impaired in the indoor space. Our developed instrument consists of a navigation system and a map information system. These systems are installed on a white cane. Our navigation system can follow a colored navigation line that is set on the floor. In this system, a color sensor installed on the tip of a white cane, this sensor senses a color of navigation line and the system informs the visually impaired that he/she is walking along the navigation line by vibration. This color recognition system is controlled by a one-chip microprocessor. RFID tags and a receiver for these tags are used in the map information system. RFID tags are set on the colored navigation line. An antenna for RFID tags and a tag receiver are also installed on a white cane. The receiver receives the area information as a tag-number and notifies map information to the user by mp3 formatted pre-recorded voice. And now, we developed the direction identification technique. Using this technique, we can detect a user's walking direction. A triaxiality acceleration sensor is used in this system. Three normal subjects who were blindfolded with an eye mask were tested with our developed navigation system. All of them were able to walk along the navigation line perfectly. We think that the performance of the system is good. Therefore, our system will be extremely valuable in supporting the activities of the visually impaired.

Local-scale changes in mean and heavy precipitation in Western Europe, climate change or internal variability?

NASA Astrophysics Data System (ADS)

Aalbers, Emma E.; Lenderink, Geert; van Meijgaard, Erik; van den Hurk, Bart J. J. M.

2017-09-01

High-resolution climate information provided by e.g. regional climate models (RCMs) is valuable for exploring the changing weather under global warming, and assessing the local impact of climate change. While there is generally more confidence in the representativeness of simulated processes at higher resolutions, internal variability of the climate system—`noise', intrinsic to the chaotic nature of atmospheric and oceanic processes—is larger at smaller spatial scales as well, limiting the predictability of the climate signal. To quantify the internal variability and robustly estimate the climate signal, large initial-condition ensembles of climate simulations conducted with a single model provide essential information. We analyze a regional downscaling of a 16-member initial-condition ensemble over western Europe and the Alps at 0.11° resolution, similar to the highest resolution EURO-CORDEX simulations. We examine the strength of the forced climate response (signal) in mean and extreme daily precipitation with respect to noise due to internal variability, and find robust small-scale geographical features in the forced response, indicating regional differences in changes in the probability of events. However, individual ensemble members provide only limited information on the forced climate response, even for high levels of global warming. Although the results are based on a single RCM-GCM chain, we believe that they have general value in providing insight in the fraction of the uncertainty in high-resolution climate information that is irreducible, and can assist in the correct interpretation of fine-scale information in multi-model ensembles in terms of a forced response and noise due to internal variability.

Making the MagIC (Magnetics Information Consortium) Web Application Accessible to New Users and Useful to Experts

NASA Astrophysics Data System (ADS)

Minnett, R.; Koppers, A.; Jarboe, N.; Tauxe, L.; Constable, C.; Jonestrask, L.

2017-12-01

Challenges are faced by both new and experienced users interested in contributing their data to community repositories, in data discovery, or engaged in potentially transformative science. The Magnetics Information Consortium (https://earthref.org/MagIC) has recently simplified its data model and developed a new containerized web application to reduce the friction in contributing, exploring, and combining valuable and complex datasets for the paleo-, geo-, and rock magnetic scientific community. The new data model more closely reflects the hierarchical workflow in paleomagnetic experiments to enable adequate annotation of scientific results and ensure reproducibility. The new open-source (https://github.com/earthref/MagIC) application includes an upload tool that is integrated with the data model to provide early data validation feedback and ease the friction of contributing and updating datasets. The search interface provides a powerful full text search of contributions indexed by ElasticSearch and a wide array of filters, including specific geographic and geological timescale filtering, to support both novice users exploring the database and experts interested in compiling new datasets with specific criteria across thousands of studies and millions of measurements. The datasets are not large, but they are complex, with many results from evolving experimental and analytical approaches. These data are also extremely valuable due to the cost in collecting or creating physical samples and the, often, destructive nature of the experiments. MagIC is heavily invested in encouraging young scientists as well as established labs to cultivate workflows that facilitate contributing their data in a consistent format. This eLightning presentation includes a live demonstration of the MagIC web application, developed as a configurable container hosting an isomorphic Meteor JavaScript application, MongoDB database, and ElasticSearch search engine. Visitors can explore the MagIC Database through maps and image or plot galleries or search and filter the raw measurements and their derived hierarchy of analytical interpretations.

Hemodynamic exercise testing. A valuable tool in the selection of cardiac transplantation candidates.

PubMed

Chomsky, D B; Lang, C C; Rayos, G H; Shyr, Y; Yeoh, T K; Pierson, R N; Davis, S F; Wilson, J R

1996-12-15

Peak exercise oxygen consumption (Vo2), a noninvasive index of peak exercise cardiac output (CO), is widely used to select candidates for heart transplantation. However, peak exercise Vo2 can be influenced by noncardiac factors such as deconditioning, motivation, or body composition and may yield misleading prognostic information. Direct measurement of the CO response to exercise may avoid this problem and more accurately predict prognosis. Hemodynamic and ventilatory responses to maximal treadmill exercise were measured in 185 ambulatory patients with chronic heart failure who had been referred for cardiac transplantation (mean left ventricular ejection fraction, 22 +/- 7%; mean peak Vo2, 12.9 +/- 3.0 mL. min-1.kg-1). CO response to exercise was normal in 83 patients and reduced in 102. By univariate analysis, patients with normal CO responses had a better 1-year survival rate (95%) than did those with reduced CO responses (72%) (P < .0001). Survival in patients with peak Vo2 of > 14 mL.min-1.kg-1 (88%) was not different from that of patients with peak Vo2 of < or = 14 mL.min-1.kg-1 (79%) (P = NS). However, survival was worse in patients with peak Vo2 of < or = 10 mL.min-1.kg-1 (52%) versus those with peak Vo2 of > 10 mL.min-1.kg-1 (89%) (P < .0001). By Cox regression analysis, exercise CO response was the strongest independent predictor of survival (risk ratio, 4.3), with peak Vo2 dichotomized at 10 mL. min-1.kg-1 (risk ratio, 3.3) as the only other independent predictor. Patients with reduced CO responses and peak Vo2 of < or = 10 mL.min-1.kg-1 had an extremely poor 1-year survival rate (38%). Both CO response to exercise and peak exercise Vo2 provide valuable independent prognostic information in ambulatory patients with heart failure. These variables should be used in combination to select potential heart transplantation candidates.

Loaded Questions: Internet Commenters’ Opinions on Physician-Patient Firearm Safety Conversations

PubMed Central

Knoepke, Christopher E.; Allen, Amanda; Ranney, Megan L.; Wintemute, Garen J.; Matlock, Daniel D.; Betz, Marian E.

2017-01-01

Introduction Medical and public health societies advocate that healthcare providers (HCPs) counsel at-risk patients to reduce firearm injury risk. Anonymous online media comments often contain extreme viewpoints and may therefore help in understanding challenges of firearm safety counseling. To help inform injury prevention efforts, we sought to examine commenters’ stated opinions regarding firearm safety counseling HCPs. Methods Qualitative descriptive analysis of online comments posted following news items (in May–June, 2016) about a peer-reviewed publication addressing when and how HCPs should counsel patients regarding firearms. Results Among 871 comments posted by 522 individuals, most (57%) were generally negative toward firearm discussions, 17% were positive, and 26% were neutral/unclear. Two major categories and multiple themes emerged. “Areas of agreement” included that discussions may be valuable (1) when addressing risk of harm to self or others, (2) in pediatric injury prevention, and (3) as general safety education (without direct questioning), and that (4) HCPs lack gun safety and cultural knowledge. “Areas of tension” included whether (1) firearms are a public health issue, (2) counseling is effective prevention practice, (3) suicide could/should be prevented, and (4) firearm safety counseling is within HCPs’ purview. Conclusion Among this set of commenters with likely extreme viewpoints, opinions were generally negative toward firearm safety conversations, but with some support in specific situations. Providing education, counseling, or materials without asking about firearm ownership was encouraged. Engaging firearm advocates when developing materials may enhance the acceptability of prevention activities. PMID:28874943

Interpreting Mammalian Evolution using Fugu Genome Comparisons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stubbs, L; Ovcharenko, I; Loots, G G

2004-04-02

Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.

Reflections on Don Juan and on the utility of the unhappy love affair.

PubMed

Bergel, Ernest

2011-12-01

Based on an unusual clinical experience of a teenage boy in child psychotherapy, two conclusions are proposed: (1) that the extremely unhappy, early love affairs that occur in most men's lives serve a valuable function in helping them separate from their mothers sufficiently to be able to realistically relate to appropriate marriage partners, and (2) that some Don Juans start new relationships in order to break them off, rather than the reverse.

Data Mining of Extremely Large Ad-Hoc Data Sets to Produce Reverse Web-Link Graphs

DTIC Science & Technology

2017-03-01

in most of the MR cases. From these studies , we also learned that computing -optimized instances should be chosen for serialized/compressed input data...maximum 200 words) Data mining can be a valuable tool, particularly in the acquisition of military intelligence. As the second study within a larger Naval...open web crawler data set Common Crawl. Similar to previous studies , this research employs MapReduce (MR) for sorting and categorizing output value

Gray Matter Heterotopia, Mental Retardation, Developmental Delay, Microcephaly, and Facial Dysmorphisms in a Boy with Ring Chromosome 6: A 10-Year Follow-Up and Literature Review.

PubMed

Liu, Shu; Wang, Zhiqing; Wei, Sisi; Liang, Jinqun; Chen, Nuan; OuYang, Haimei; Zeng, Weihong; Chen, Liying; Xie, Xunjie; Jiang, Jianhui

2018-04-14

Ring chromosome 6, r(6), is an extremely rare cytogenetic abnormality with clinical heterogeneity which arises typically de novo. The phenotypes of r(6) can be highly variable, ranging from almost normal to severe malformations and neurological defects. Up to now, only 33 cases have been reported in the literature. In this 10-year follow-up study, we report a case presenting distinctive facial features, severe developmental delay, and gray matter heterotopia with r(6) and terminal deletions of 6p25.3 (115426-384174, 268 kb) and 6q26-27 (168697778-170732033, 2.03 Mb) encompassing 2 and 15 candidate genes, respectively, which were detected using G-banding karyotyping, FISH, and chromosomal microarray analysis. We also analyzed the available information on the clinical features of the reported r(6) cases in order to provide more valuable information on genotype-phenotype correlations. To the best of our knowledge, this is the first report of gray matter heterotopia manifested in a patient with r(6) in China, and the deletions of 6p and 6q in our case are the smallest with the precise size of euchromatic material loss currently known. © 2018 S. Karger AG, Basel.

Long-term monitoring on environmental disasters using multi-source remote sensing technique

NASA Astrophysics Data System (ADS)

Kuo, Y. C.; Chen, C. F.

2017-12-01

Environmental disasters are extreme events within the earth's system that cause deaths and injuries to humans, as well as causing damages and losses of valuable assets, such as buildings, communication systems, farmlands, forest and etc. In disaster management, a large amount of multi-temporal spatial data is required. Multi-source remote sensing data with different spatial, spectral and temporal resolutions is widely applied on environmental disaster monitoring. With multi-source and multi-temporal high resolution images, we conduct rapid, systematic and seriate observations regarding to economic damages and environmental disasters on earth. It is based on three monitoring platforms: remote sensing, UAS (Unmanned Aircraft Systems) and ground investigation. The advantages of using UAS technology include great mobility and availability in real-time rapid and more flexible weather conditions. The system can produce long-term spatial distribution information from environmental disasters, obtaining high-resolution remote sensing data and field verification data in key monitoring areas. It also supports the prevention and control on ocean pollutions, illegally disposed wastes and pine pests in different scales. Meanwhile, digital photogrammetry can be applied on the camera inside and outside the position parameters to produce Digital Surface Model (DSM) data. The latest terrain environment information is simulated by using DSM data, and can be used as references in disaster recovery in the future.

Analysis and interpretation of satellite fragmentation data

NASA Technical Reports Server (NTRS)

Tan, Arjun

1987-01-01

The velocity perturbations of the fragments of a satellite can shed valuable information regarding the nature and intensity of the fragmentation. A feasibility study on calculating the velocity perturbations from existing equations was carried out by analyzing 23 major documented fragmentation events. It was found that whereas the calculated values of the radial components of the velocity change were often unusually high, those in the two other orthogonal directions were mostly reasonable. Since the uncertainties in the radial component necessarily translate into uncertainties in the total velocity change, it is suggested that alternative expressions for the radial component of velocity be sought for the purpose of determining the cause of the fragmentation from the total velocity change. The calculated variances in the velocity perturbations in the two directions orthogonal to the radial vector indicate that they have the smallest values for collision induced breakups and the largest values for low-intensity explosion induced breakups. The corresponding variances for high-intensity explosion induced breakups generally have values intermediate between those of the two extreme categories. A three-dimensional plot of the variances in the two orthogonal velocity perturbations and the plane change angle shows a clear separation between the three major types of breakups. This information is used to reclassify a number of satellite fragmentation events of unknown category.

A place-based model for assessing the coherence of the flash floods and socio-economic vulnerability across the Contiguous United States (CONUS)

NASA Astrophysics Data System (ADS)

Khajehei, S.; Moradkhani, H.

2017-12-01

Understanding socio-economic characteristics involving natural hazards potential, vulnerability, and resilience is necessary to address the damages to economy and loss of life from extreme natural hazards. The vulnerability to flash floods is dependent on both biophysical and socio-economic factors. Although the biophysical characteristics (e.g. climate, vegetation, and land use) are informative and useful for predicting spatial and temporal extent of flash floods, they have minimal bearing on predicting when and where flash floods are likely to influence people or damage valuable assets and resources. The socio-economic factors determine spatial and temporal scales of the regions affected by flash floods. In this study, we quantify the socio-economic vulnerability to flash floods across the Contiguous United States (CONUS). A socio-economic vulnerability index was developed, employing Bayesian principal components for each state in the CONUS. For this purpose, extensive sets of social and economic variables from US Census and the Bureau of Economic Analysis were used. We developed maps presenting the coincidence of socio-economic vulnerability and the flash floods records. This product can help inform flash flood prevention, mitigation and recovery planning, as well as reducing the flash flood hazards affecting vulnerable places and population.

Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Huang, Yong; Tong, Dedi; Zhu, Shan; Wu, Lehao; Ibrahim, Zuhaib; Lee, WP Andrew; Brandacher, Gerald; Kang, Jin U.

2014-03-01

Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical coherence tomography (OCT) is a non-invasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. Phaseresolved Doppler OCT that explores the phase information of OCT signals has been shown to be capable of characterizing dynamic blood flow clinically. In this work, we explore the capability of Fourier domain Doppler OCT as an evaluation tool to detect commonly encountered post-operative complications that will cause surgical failure and to confirm positive result with surgeon's observation. Both suture and cuff based techniques were evaluated on the femoral artery and vein in the rodent model.

Characteristics, perceptions, and other factors influencing physical therapist assistant program directors in 2001.

PubMed

Page, Catherine G

2003-01-01

Little is known about program directors in physical therapist assistant (PTA) programs. This study describes the characteristics of program directors in PTA programs, such as time spent on responsibilities, influences on decision making, perceptions of current working relationships, and satisfaction with decision making. Program directors of 153 (57.5%) accredited PTA programs responded to the survey. The self-reported data were generated by a mail survey developed by the investigator that included 32 demographic items and 58 Likert-scale items to meet the purpose of the study. The data suggest that PTA program directors have average to extremely good levels of satisfaction with their positions and spend more time on student-related and accreditation/long range planning activities than they do on other activities. Information on years of experience and types of degrees suggest that respondents have a great deal of physical therapy experience but much less experience in teaching and administration within community colleges. This information may be valuable for people who seek, or who are recruited for, PTA program director positions. It provides a foundational database for periodic studies of PTA program directors. As enrollments and new programs stabilize and as new program directors are appointed, their impact on physical therapy education and the profession must be reevaluated.

Variation in contents of main active components and antioxidant activity in leaves of different pigeon pea cultivars during growth.

PubMed

Wei, Zuo-Fu; Jin, Shuang; Luo, Meng; Pan, You-Zhi; Li, Ting-Ting; Qi, Xiao-Lin; Efferth, Thomas; Fu, Yu-Jie; Zu, Yuan-Gang

2013-10-23

Pigeon pea is an important and multiuse grain legume crop, and its leaves are a very valuable natural resource. To obtain a high-quality biological resource, it is necessary to choose the excellent cultivar and determine the appropriate harvest time. In this study, the variation in contents of main active components and antioxidant activity in leaves of six pigeon pea cultivars during growth were investigated. The level of each individual active component significantly varied during growth, but with a different pattern, and this variation was different among cultivars. Flavonoid glycosides orientin, vitexin, and apigenin-6,8-di-C-α-L-arabinopyranoside showed two peak values at mid-late and final stages of growth in most cases. Pinostrobin chalcone, longistyline C, and cajaninstilbene acid showed remarkablely higher values at the mid-late stage of growth than at other stages. Pinostrobin had an extremely different variation pattern compared to other active components. Its content was the highest at the earlier stage of growth. Principal component analysis (PCA) revealed that vitexin and apigenin-6,8-di-C-α-L-arabinopyranoside were mainly responsible for distinguishing cultivars analyzed. In a comprehensive consideration, the leaves should preferentially be harvested at the 135th day after sowing when the level of active components and antioxidant activity reached higher values. Cultivars ICP 13092, ICPL 87091, and ICPL 96053 were considered to be excellent cultivars with high antioxidant activity. Our findings can provide valuable information for producing a high-quality pigeon pea resource.

All-Direction Random Routing for Source-Location Privacy Protecting against Parasitic Sensor Networks.

PubMed

Wang, Na; Zeng, Jiwen

2017-03-17

Wireless sensor networks are deployed to monitor the surrounding physical environments and they also act as the physical environments of parasitic sensor networks, whose purpose is analyzing the contextual privacy and obtaining valuable information from the original wireless sensor networks. Recently, contextual privacy issues associated with wireless communication in open spaces have not been thoroughly addressed and one of the most important challenges is protecting the source locations of the valuable packages. In this paper, we design an all-direction random routing algorithm (ARR) for source-location protecting against parasitic sensor networks. For each package, the routing process of ARR is divided into three stages, i.e., selecting a proper agent node, delivering the package to the agent node from the source node, and sending it to the final destination from the agent node. In ARR, the agent nodes are randomly chosen in all directions by the source nodes using only local decisions, rather than knowing the whole topology of the networks. ARR can control the distributions of the routing paths in a very flexible way and it can guarantee that the routing paths with the same source and destination are totally different from each other. Therefore, it is extremely difficult for the parasitic sensor nodes to trace the packages back to the source nodes. Simulation results illustrate that ARR perfectly confuses the parasitic nodes and obviously outperforms traditional routing-based schemes in protecting source-location privacy, with a marginal increase in the communication overhead and energy consumption. In addition, ARR also requires much less energy than the cloud-based source-location privacy protection schemes.

76 FR 7121 - Privacy Act of 1974; Proposed Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

... identity of confidential sources and the nature of the information supplied by informants as well as... the information. Confidential sources and informers might refuse to provide valuable information... nature of the information they supplied. Loss of access to such sources would seriously impair the...

Water Cycle Extremes: from Observations to Decisions

NASA Astrophysics Data System (ADS)

Lawford, R. G.; Unninayar, S.; Berod, D.

2015-12-01

Extremes in the water cycle (droughts and floods) pose major challenges for water resource managers and emergency services. These challenges arise from observational and prediction systems, advisory services, impact reduction strategies, and cleanup and recovery operations. The Group on Earth Observations (GEO) through its Water Strategy ("GEOSS Water Strategy: from observations to decisions") is seeking to provide systems that will enable its members to more effectively meet their information needs prior to and during an extreme event. This presentation reviews the wide range of impacts that arise from extremes in the water cycle and the types of data and information needed to plan for and respond to these extreme events. It identifies the capabilities and limitations of current observational and analysis systems in defining the scale, timing, intensity and impacts of water cycle extremes and in directing society's response to them. This summary represents an early preliminary assessment of the global and regional information needs of water resource managers and begins to outline a strategy within GEO for using Earth Observations and ancillary information to address these needs.

E-oncology and health portals: instructions and standards for the evaluation, production organisation and use.

PubMed

Cognetti, G; Cecere, L

2003-12-01

In 2002 the Italian Ministry of Health promoted the institution of a network and a web portal, E-oncology (2), for the seven NHS research institutions specialising in oncology (Istituti di Ricovero e Cura a Carattere Scientifico-IRCCS). One of the aims was to gather and provide information on tumoral pathologies to operators and the public. For an optimum organisation of a health web site it is necessary to comply with the standards internationally used. The World Wide Web Consortium (W3C) has developed guidelines for accessibility and usability of the sites, implemented in Italy through governmental issues. Many international organisations adopt rules and codes of conduct to validate biomedical information and have organised quality portals such as NLM, OMNI, MEDCIRCLE, HON etc. Some terminological standards, such as the MESH thesaurus and UMLS, have been produced by the libraries for a correct management and an effective information retrieval, and are currently used by the most important biomedical web sites. The Dublin Core, metadata standard for the integration of information deriving from heterogeneous archives, has also been developed by the libraries. The easy access to information dims the complex architecture necessary for the construction of a web site. The contribution of different professionals is necessary to guarantee the production of quality medical/health web sites, among them librarians have always been involved with the management of knowledge and their skills are extremely valuable. Furthermore, the libraries' network is essential in order to guarantee universal access to health information, mostly still against payment, and to contribute to overcoming the 'digital divide' and 'second-level digital divide'.

454-pyrosequencing: A tool for discovery and biomarker development

USDA-ARS?s Scientific Manuscript database

The Roche GS-FLX (454) sequencer has made possible what was thought impossible just a few years ago: sequence >1 million high-quality nucleotide reads (mean 400 bp) in less than 12 h. This technology provides valuable species-specific sequence information, and is a valuable tool to discover and und...

EEG - A Valuable Biomarker of Brain Injury in Preterm Infants.

PubMed

Pavlidis, Elena; Lloyd, Rhodri O; Boylan, Geraldine B

2017-01-01

This review focuses on the role of electroencephalography (EEG) in monitoring abnormalities of preterm brain function. EEG features of the most common developmental brain injuries in preterm infants, including intraventricular haemorrhage, periventricular leukomalacia, and perinatal asphyxia, are described. We outline the most common EEG biomarkers associated with these injuries, namely seizures, positive rolandic sharp waves, EEG suppression/increased interburst intervals, mechanical delta brush activity, and other deformed EEG waveforms, asymmetries, and asynchronies. The increasing survival rate of preterm infants, in particular those that are very and extremely preterm, has led to a growing demand for a specific and shared characterization of the patterns related to adverse outcome in this unique population. This review includes abundant high-quality images of the EEG patterns seen in premature infants and will provide a valuable resource for everyone working in developmental neuroscience. © 2017 S. Karger AG, Basel.

The role of space borne imaging radars in environmental monitoring: Some shuttle imaging radar results in Asia

NASA Technical Reports Server (NTRS)

Imhoff, M.; Vermillion, C.

1986-01-01

The synoptic view afforded by orbiting Earth sensors can be extremely valuable for resource evaluation, environmental monitoring and development planning. For many regions of the world, however, cloud cover has prevented the acquisition of remotely sensed data during the most environmentally stressful periods of the year. This paper discusses how synthetic aperture imaging radar can be used to provide valuable data about the condition of the Earth's surface during periods of bad weather. Examples are given of applications using data from the Shuttle Imaging Radars (SIR) A and B for agriculture land use and crop condition assessment, monsoon flood boundary and flood damage assessment, water resource monitoring and terrain modeling, coastal forest mapping and vegetation penetration, and coastal development monitoring. Recent SIR-B results in Bangladesh are emphasized, radar system basics are reviewed and future SAR systems discussed.

The role of space borne imaging radars in environmental monitoring: Some shuttle imaging radar results in Asia

NASA Technical Reports Server (NTRS)

Imhoff, Marc L.; Vermillion, C. H.

1986-01-01

The synoptic view afforded by orbiting Earth sensors can be extremely valuable for resource evaluation, environmental monitoring and development planning. For many regions of the world, however, cloud cover has prevented the acquisition of remotely sensed data during the most environmentally stressful periods of the year. How synthetic aperture imaging radar can be used to provide valuable data about the condition of the Earth's surface during periods of bad weather is discussed. Examples are given of applications using data from the Shuttle Imaging Radars (SIR) A and B for agricultural land use and crop condition assessment, monsoon flood boundary and flood damage assessment, water resource monitoring and terrain modeling, coastal forest mapping and vegetation penetration, and coastal development monitoring. Recent SIR-B results in Bangladesh are emphasized, radar system basics are reviewed and future SAR systems are discussed.

Effect of censoring trace-level water-quality data on trend-detection capability

USGS Publications Warehouse

Gilliom, R.J.; Hirsch, R.M.; Gilroy, E.J.

1984-01-01

Monte Carlo experiments were used to evaluate whether trace-level water-quality data that are routinely censored (not reported) contain valuable information for trend detection. Measurements are commonly censored if they fall below a level associated with some minimum acceptable level of reliability (detection limit). Trace-level organic data were simulated with best- and worst-case estimates of measurement uncertainty, various concentrations and degrees of linear trend, and different censoring rules. The resulting classes of data were subjected to a nonparametric statistical test for trend. For all classes of data evaluated, trends were most effectively detected in uncensored data as compared to censored data even when the data censored were highly unreliable. Thus, censoring data at any concentration level may eliminate valuable information. Whether or not valuable information for trend analysis is, in fact, eliminated by censoring of actual rather than simulated data depends on whether the analytical process is in statistical control and bias is predictable for a particular type of chemical analyses.

At War in the Shadow of Vietnam: United States Military Aid to the Royal LAO Government 1955-75

DTIC Science & Technology

1991-05-01

number of other people interrupted their busy schedules to read drafts of this dissertation. Professor William M. iv Leary, University of Georgia... busy schedule to talk with me about the activities of the CIA and Air America in Laos. His comments on guerilla warfare were extremely vi valuable...Vietnam and the Mekong valley. These features have also given the plain an important strategic value. For centuries, armies have crossed through the

The anthropology of Carl Jung: Implications for pastoral care.

PubMed

Hunt-Meeks, S

1983-09-01

This article examines the basic tenets of Carl Jung's anthropology, including intrapsychic structure, relationships, society, and the process of individuation. It then turns to his ideas about God and religion. Jung builds his understanding of God from his work in psychology, and because of that method, there are several major problems with his theologizing. Nevertheless, his insights are extremely valuable to the field of pastoral care, and ministers would do very well to appreciate his contribution, though always with a critical eye to its limitation.

The Theory of Canonical Perturbations Applied to Attitude Dynamics and to the Earth Rotation. Osculating and Nonosculating Andoyer Variables

DTIC Science & Technology

2007-06-21

Hiroshi Kinoshita for his extremely valuable consultations on some subtleties of his theory. ME is also grateful to Pini Gurfil , George Kaplan, Jean...that the Andoyer elements are introduced 20 It can be shown ( Gurfil et al. 2007) that the body-frame-related components gi of the angular momentum are...oblate precessing planet. Astron. J. 70, 5–9 (1965) Goldstein, H.: Classical Mechanics. 2nd ed. Addison-Wesley, Reading MA (1981) Gurfil , P., Elipe

Microbial copper resistance: importance in biohydrometallurgy.

PubMed

Martínez-Bussenius, Cristóbal; Navarro, Claudio A; Jerez, Carlos A

2017-03-01

Industrial biomining has been extensively used for many years to recover valuable metals such as copper, gold, uranium and others. Furthermore, microorganisms involved in these processes can also be used to bioremediate places contaminated with acid and metals. These uses are possible due to the great metal resistance that these extreme acidophilic microorganisms possess. In this review, the most recent findings related to copper resistance mechanisms of bacteria and archaea related to biohydrometallurgy are described. The recent search for novel metal resistance determinants is not only of scientific interest but also of industrial importance, as reflected by the genomic sequencing of microorganisms present in mining operations and the search of those bacteria with extreme metal resistance to improve the extraction processes used by the biomining companies. © 2016 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

Modeling Effects of Annealing on Coal Char Reactivity to O 2 and CO 2 , Based on Preparation Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holland, Troy; Bhat, Sham; Marcy, Peter

Oxy-fired coal combustion is a promising potential carbon capture technology. Predictive computational fluid dynamics (CFD) simulations are valuable tools in evaluating and deploying oxyfuel and other carbon capture technologies, either as retrofit technologies or for new construction. However, accurate predictive combustor simulations require physically realistic submodels with low computational requirements. A recent sensitivity analysis of a detailed char conversion model (Char Conversion Kinetics (CCK)) found thermal annealing to be an extremely sensitive submodel. In the present work, further analysis of the previous annealing model revealed significant disagreement with numerous datasets from experiments performed after that annealing model was developed. Themore » annealing model was accordingly extended to reflect experimentally observed reactivity loss, because of the thermal annealing of a variety of coals under diverse char preparation conditions. The model extension was informed by a Bayesian calibration analysis. In addition, since oxyfuel conditions include extraordinarily high levels of CO 2, the development of a first-ever CO 2 reactivity loss model due to annealing is presented.« less

Modeling Effects of Annealing on Coal Char Reactivity to O 2 and CO 2 , Based on Preparation Conditions

DOE PAGES

Holland, Troy; Bhat, Sham; Marcy, Peter; ...

2017-08-25

Oxy-fired coal combustion is a promising potential carbon capture technology. Predictive computational fluid dynamics (CFD) simulations are valuable tools in evaluating and deploying oxyfuel and other carbon capture technologies, either as retrofit technologies or for new construction. However, accurate predictive combustor simulations require physically realistic submodels with low computational requirements. A recent sensitivity analysis of a detailed char conversion model (Char Conversion Kinetics (CCK)) found thermal annealing to be an extremely sensitive submodel. In the present work, further analysis of the previous annealing model revealed significant disagreement with numerous datasets from experiments performed after that annealing model was developed. Themore » annealing model was accordingly extended to reflect experimentally observed reactivity loss, because of the thermal annealing of a variety of coals under diverse char preparation conditions. The model extension was informed by a Bayesian calibration analysis. In addition, since oxyfuel conditions include extraordinarily high levels of CO 2, the development of a first-ever CO 2 reactivity loss model due to annealing is presented.« less

A New Paradigm in Earth Environmental Monitoring with the CYGNSS Small Satellite Constellation.

PubMed

Ruf, Christopher S; Chew, Clara; Lang, Timothy; Morris, Mary G; Nave, Kyle; Ridley, Aaron; Balasubramaniam, Rajeswari

2018-06-08

A constellation of small, low-cost satellites is able to make scientifically valuable measurements of the Earth which can be used for weather forecasting, disaster monitoring, and climate studies. Eight CYGNSS satellites were launched into low Earth orbit on December 15, 2016. Each satellite carries a science radar receiver which measures GPS signals reflected from the Earth surface. The signals contain information about the surface, including wind speed over ocean, and soil moisture and flooding over land. The satellites are distributed around their orbit plane so that measurements can be made more often to capture extreme weather events. Innovative engineering approaches are used to reduce per satellite cost, increase the number in the constellation, and improve temporal sampling. These include the use of differential drag rather than propulsion to adjust the spacing between satellites and the use of existing GPS signals as the science radars' transmitter. Initial on-orbit results demonstrate the scientific utility of the CYGNSS observations, and suggest that a new paradigm in spaceborne Earth environmental monitoring is possible.

Tracing origins of complex pharmaceutical preparations using surface desorption atmospheric pressure chemical ionization mass spectrometry.

PubMed

Zhang, Xinglei; Jia, Bin; Huang, Keke; Hu, Bin; Chen, Rong; Chen, Huanwen

2010-10-01

A novel strategy to trace the origins of commercial pharmaceutical products has been developed based on the direct chemical profiling of the pharmaceutical products by surface desorption atmospheric pressure chemical ionization mass spectrometry (DAPCI-MS). Besides the unambiguous identification of active drug components, various compounds present in the matrixes are simultaneously detected without sample pretreatment, providing valuable information for drug quality control and origin differentiation. Four sources of commercial amoxicillin products made by different manufacturers have been successfully differentiated. This strategy has been extended to secerning six sources of Liuwei Dihuang Teapills, which are herbal medicine preparations with extremely complex matrixes. The photolysis status of chemical drug products and the inferior natural herd medicine products prepared with different processes (e.g., extra heating) were also screened using the method reported here. The limit of detection achieved in the MS/MS experiments was estimated to be 1 ng/g for amoxicillin inside the capsule product. Our experimental data demonstrate that DAPCI-MS is a useful tool for rapid pharmaceutical analysis, showing promising perspectives for tracking the entire pharmaceutical supply chain to prevent counterfeit intrusions.

Integrating Crystallography into Early Metabolism Studies

NASA Astrophysics Data System (ADS)

Cruciani, Gabriele; Aristei, Yasmin; Goracci, Laura; Carosati, Emanuele

Since bioavailability, activity, toxicity, distribution, and final elimination all depend on metabolic biotransformations, it would be extremely advantageous if this information to be produced early in the discovery phase. Once obtained, researchers can judge whether or not a potential candidate should be eliminated from the pipeline, or modified to improve chemical stability or safety. The use of in silico methods to predict the site of metabolism in Phase I cytochrome-mediated reactions is a starting point in any metabolic pathway prediction. This paper presents a new method, which provides the site of metabolism for any CYP-mediated reaction acting on unknown substrates. The methodology can be applied automatically to all the cytochromes whose Xray 3D structure is known, but can be also applied to homology model 3D structures. The fully automated procedure can be used to detect positions that should be protected in order to avoid metabolic degradation, or to check the suitability of a new scaffold or pro-drug. Therefore the procedure is also a valuable new tool in early ADME-Tox, where drug-safety and metabolic profile patterns must be evaluated as soon, and as early, as possible.

Computational imaging of light in flight

NASA Astrophysics Data System (ADS)

Hullin, Matthias B.

2014-10-01

Many computer vision tasks are hindered by image formation itself, a process that is governed by the so-called plenoptic integral. By averaging light falling into the lens over space, angle, wavelength and time, a great deal of information is irreversibly lost. The emerging idea of transient imaging operates on a time resolution fast enough to resolve non-stationary light distributions in real-world scenes. It enables the discrimination of light contributions by the optical path length from light source to receiver, a dimension unavailable in mainstream imaging to date. Until recently, such measurements used to require high-end optical equipment and could only be acquired under extremely restricted lab conditions. To address this challenge, we introduced a family of computational imaging techniques operating on standard time-of-flight image sensors, for the first time allowing the user to "film" light in flight in an affordable, practical and portable way. Just as impulse responses have proven a valuable tool in almost every branch of science and engineering, we expect light-in-flight analysis to impact a wide variety of applications in computer vision and beyond.

New psychoactive substance α-PVP in a traffic accident case.

PubMed

Rojek, Sebastian; Kula, Karol; Maciów-Głąb, Martyna; Kłys, Małgorzata

The problems of new psychoactive substances (NPSs), especially related to drivers, constitute an open research area. In this case report, we present a traffic accident case, in which two passengers of five individuals died instantly, while the other three persons survived the accident with minor injuries only. From the blood samples of the driver and the passengers, α-pyrrolidinovalerophenone (α-PVP), an NPS belonging to the category of cathinone derivatives, was disclosed. Therefore, we established a detailed procedure for analysis of α-PVP in blood samples by liquid chromatography-tandem mass spectrometry. After careful validation tests of this method, α-PVP concentration in blood samples from the surviving driver and passengers, and from the two deceased, were measured. The concentrations varied from 20 to 650 ng/mL. Access to detailed information originating from the court files and from explanations provided by the driver and eye witnesses revealed extremely valuable illustrative details addressing the symptoms and pharmacological effects of α-PVP on the human organism, thus contributing to enriching the body of knowledge of α-PVP abuse.

Numerical modeling of hydrodynamics and sediment transport—an integrated approach

NASA Astrophysics Data System (ADS)

Gic-Grusza, Gabriela; Dudkowska, Aleksandra

2017-10-01

Point measurement-based estimation of bedload transport in the coastal zone is very difficult. The only way to assess the magnitude and direction of bedload transport in larger areas, particularly those characterized by complex bottom topography and hydrodynamics, is to use a holistic approach. This requires modeling of waves, currents, and the critical bed shear stress and bedload transport magnitude, with a due consideration to the realistic bathymetry and distribution of surface sediment types. Such a holistic approach is presented in this paper which describes modeling of bedload transport in the Gulf of Gdańsk. Extreme storm conditions defined based on 138-year NOAA data were assumed. The SWAN model (Booij et al. 1999) was used to define wind-wave fields, whereas wave-induced currents were calculated using the Kołodko and Gic-Grusza (2015) model, and the magnitude of bedload transport was estimated using the modified Meyer-Peter and Müller (1948) formula. The calculations were performed using a GIS model. The results obtained are innovative. The approach presented appears to be a valuable source of information on bedload transport in the coastal zone.

A New ɛNd Record Covering Termination II

NASA Astrophysics Data System (ADS)

Deaney, E. L.; Thornalley, D. J.; van de Flierdt, T.; Kreissig, K.; Barker, S.

2014-12-01

The 143Nd/144Nd ratio (ɛNd) of seawater is used as a quasi-conservative tracer to examine past changes in water mass composition of the deep ocean. Records of ɛNd across the last deglaciation (Termination 1, T1) provide valuable information about water mass mixing that has improved our understanding of the ocean dynamics relevant to the process of deglaciation. However, questions remain concerning end-member source characteristics and regional hydrographic processes. Here we present a high resolution record of ɛNd derived from fish debris from ODP site 1063 across Termination 2. The different external and internal forcing (e.g. insolation versus freshwater) applicable to T2 make this a useful comparator for studies focused on T1. Accordingly we find large (up to 4 ɛNd units) fluctuations across T2 that can be related to high latitude climate changes as recorded by ice cores and other high resolution climate archives. We also identify periods of extremely negative values that require new explanations for changing end-member compositions. Our results have important implications for understanding North Atlantic deep water formation processes during critical climate transitions.

Exploring the Microbiome of Callinectes sapidus (Maryland Blue Crab)

PubMed Central

Reed, Elizabeth; Ottesen, Andrea

2018-01-01

ABSTRACT The Maryland blue crab (Callinectes sapidus) is a treasured food, especially in areas surrounding the Chesapeake Bay. It has huge economic impact on commerce, and thus, understanding the bacterial, fungal, and viral constituents of its microbiome provides valuable information to safely manage aquaculture, handling, and cooking of this valuable commodity. PMID:29853506

A view from above: use of satellite imagery to enhance our understanding of potential impacts of climate change on human health in the Arctic.

PubMed

Maynard, Nancy G; Conway, George A

2007-01-01

Provide an overview and examples of some of the remote sensing technologies presently or potentially available, which could be used to address environmental health problems in the Arctic. The vulnerability of Arctic populations to health impacts from environmental, weather, and climate-related factors underscores the need for increased applications of technologies such as remote sensing, Geographic Information Systems (GIS), and global positioning systems (GPS) for empowering local health officials and decision-makers to better predict environment-related health problems, decrease vulnerabilities, take preventative measures, and improve community response actions as well as increase community health literacy. These increased capabilities for monitoring, risk mapping, information sharing, communications, and surveillance of environmental parameters are powerful tools for addressing such environmentally-related health problems as thermal stress; extreme weather; contaminant transport and deposition into oceans, atmosphere, and ice; air and water quality; built environment impacts; ultraviolet radiation (UV); and infectious and vector-borne diseases. For example, systems are now in place, which can observe ocean parameters, providing information on algal blooms, pollutants and pathogens as well as storm assessments and sea level rise. Space-based systems in place can contribute valuable information through monitoring the processes of long-range transport of pollutants to the Arctic, where accumulation in animals and plants can occur. It is well-known that biomagnification up the food chain and ultimate consumption as traditional foods by indigenous peoples have resulted in some of the highest exposures in the world to certain contaminants.

Recent Weather Extremes and Impacts on Agricultural Production and Vector-Borne Disease Outbreak Patterns

NASA Technical Reports Server (NTRS)

Anyamba, Assaf; Small, Jennifer L.; Britch, Seth C.; Tucker, Compton J.; Pak, Edwin W.; Reynolds, Curt A.; Crutchfield, James; Linthicum, Kenneth J.

2014-01-01

We document significant worldwide weather anomalies that affected agriculture and vector-borne disease outbreaks during the 2010-2012 period. We utilized 2000-2012 vegetation index and land surface temperature data from NASA's satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to map the magnitude and extent of these anomalies for diverse regions including the continental United States, Russia, East Africa, Southern Africa, and Australia. We demonstrate that shifts in temperature and/or precipitation have significant impacts on vegetation patterns with attendant consequences for agriculture and public health. Weather extremes resulted in excessive rainfall and flooding as well as severe drought, which caused,10 to 80% variation in major agricultural commodity production (including wheat, corn, cotton, sorghum) and created exceptional conditions for extensive mosquito-borne disease outbreaks of dengue, Rift Valley fever, Murray Valley encephalitis, and West Nile virus disease. Analysis of MODIS data provided a standardized method for quantifying the extreme weather anomalies observed during this period. Assessments of land surface conditions from satellite-based systems such as MODIS can be a valuable tool in national, regional, and global weather impact determinations.

Long-lasting Extreme Magnetic Storm Activities in 1770 Found in Historical Documents

NASA Astrophysics Data System (ADS)

Hayakawa, Hisashi; Iwahashi, Kiyomi; Ebihara, Yusuke; Tamazawa, Harufumi; Shibata, Kazunari; Knipp, Delores J.; Kawamura, Akito D.; Hattori, Kentaro; Mase, Kumiko; Nakanishi, Ichiro; Isobe, Hiroaki

2017-12-01

Dim red aurora at low magnetic latitudes is a visual and recognized manifestation of magnetic storms. The great low-latitude auroral displays seen throughout East Asia on 1770 September 16-18 are considered to manifest one of the greatest storms. Recently found, 111 historical documents in East Asia attest that these low-latitude auroral displays appeared in succession for almost nine nights during 1770 September 10-19 in low magnetic latitude areas (<30°). This suggests that the duration of the great magnetic storm is much longer than usual. Sunspot drawings from 1770 reveal that the sunspot areas were twice as large as those observed in another great storm of 1859, which substantiates these unusual storm activities in 1770. These spots likely ejected several huge, sequential magnetic structures in short duration into interplanetary space, resulting in spectacular worldwide aurorae in mid-September of 1770. These findings provide new insight into the history, duration, and effects of extreme magnetic storms that may be valuable for those who need to mitigate against extreme events.

Recent weather extremes and impacts on agricultural production and vector-borne disease outbreak patterns.

PubMed

Anyamba, Assaf; Small, Jennifer L; Britch, Seth C; Tucker, Compton J; Pak, Edwin W; Reynolds, Curt A; Crutchfield, James; Linthicum, Kenneth J

2014-01-01

We document significant worldwide weather anomalies that affected agriculture and vector-borne disease outbreaks during the 2010-2012 period. We utilized 2000-2012 vegetation index and land surface temperature data from NASA's satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to map the magnitude and extent of these anomalies for diverse regions including the continental United States, Russia, East Africa, Southern Africa, and Australia. We demonstrate that shifts in temperature and/or precipitation have significant impacts on vegetation patterns with attendant consequences for agriculture and public health. Weather extremes resulted in excessive rainfall and flooding as well as severe drought, which caused ∼10 to 80% variation in major agricultural commodity production (including wheat, corn, cotton, sorghum) and created exceptional conditions for extensive mosquito-borne disease outbreaks of dengue, Rift Valley fever, Murray Valley encephalitis, and West Nile virus disease. Analysis of MODIS data provided a standardized method for quantifying the extreme weather anomalies observed during this period. Assessments of land surface conditions from satellite-based systems such as MODIS can be a valuable tool in national, regional, and global weather impact determinations.

Overview of Key Results from SDO Extreme ultraviolet Variability Experiment (EVE)

NASA Astrophysics Data System (ADS)

Woods, Tom; Eparvier, Frank; Jones, Andrew; Mason, James; Didkovsky, Leonid; Chamberlin, Phil

2016-10-01

The SDO Extreme ultraviolet Variability Experiment (EVE) includes several channels to observe the solar extreme ultraviolet (EUV) spectral irradiance from 1 to 106 nm. These channels include the Multiple EUV Grating Spectrograph (MEGS) A, B, and P channels from the University of Colorado (CU) and the EUV SpectroPhometer (ESP) channels from the University of Southern California (USC). The solar EUV spectrum is rich in many different emission lines from the corona, transition region, and chromosphere. The EVE full-disk irradiance spectra are important for studying the solar impacts in Earth's ionosphere and thermosphere and are useful for space weather operations. In addition, the EVE observations, with its high spectral resolution of 0.1 nm and in collaboration with AIA solar EUV images, have proven valuable for studying active region evolution and explosive energy release during flares and coronal eruptions. These SDO measurements have revealed interesting results such as understanding the flare variability over all wavelengths, discovering and classifying different flare phases, using coronal dimming measurements to predict CME properties of mass and velocity, and exploring the role of nano-flares in continual heating of active regions.

Force Field Accelerated Density Functional Theory Molecular Dynamics for Simulation of Reactive Systems at Extreme Conditions

NASA Astrophysics Data System (ADS)

Lindsey, Rebecca; Goldman, Nir; Fried, Laurence

Understanding chemistry at extreme conditions is crucial in fields including geochemistry, astrobiology, and alternative energy. First principles methods can provide valuable microscopic insights into such systems while circumventing the risks of physical experiments, however the time and length scales associated with chemistry at extreme conditions (ns and μm, respectively) largely preclude extension of such models to molecular dynamics. In this work, we develop a simulation approach that retains the accuracy of density functional theory (DFT) while decreasing computational effort by several orders of magnitude. We generate n-body descriptions for atomic interactions by mapping forces arising from short density functional theory (DFT) trajectories on to simple Chebyshev polynomial series. We examine the importance of including greater than 2-body interactions, model transferability to different state points, and discuss approaches to ensure smooth and reasonable model shape outside of the distance domain sampled by the DFT training set. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Text mining approach to predict hospital admissions using early medical records from the emergency department.

PubMed

Lucini, Filipe R; S Fogliatto, Flavio; C da Silveira, Giovani J; L Neyeloff, Jeruza; Anzanello, Michel J; de S Kuchenbecker, Ricardo; D Schaan, Beatriz

2017-04-01

Emergency department (ED) overcrowding is a serious issue for hospitals. Early information on short-term inward bed demand from patients receiving care at the ED may reduce the overcrowding problem, and optimize the use of hospital resources. In this study, we use text mining methods to process data from early ED patient records using the SOAP framework, and predict future hospitalizations and discharges. We try different approaches for pre-processing of text records and to predict hospitalization. Sets-of-words are obtained via binary representation, term frequency, and term frequency-inverse document frequency. Unigrams, bigrams and trigrams are tested for feature formation. Feature selection is based on χ 2 and F-score metrics. In the prediction module, eight text mining methods are tested: Decision Tree, Random Forest, Extremely Randomized Tree, AdaBoost, Logistic Regression, Multinomial Naïve Bayes, Support Vector Machine (Kernel linear) and Nu-Support Vector Machine (Kernel linear). Prediction performance is evaluated by F1-scores. Precision and Recall values are also informed for all text mining methods tested. Nu-Support Vector Machine was the text mining method with the best overall performance. Its average F1-score in predicting hospitalization was 77.70%, with a standard deviation (SD) of 0.66%. The method could be used to manage daily routines in EDs such as capacity planning and resource allocation. Text mining could provide valuable information and facilitate decision-making by inward bed management teams. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Symbiont community stability through severe coral bleaching in a thermally extreme lagoon.

PubMed

Smith, E G; Vaughan, G O; Ketchum, R N; McParland, D; Burt, J A

2017-05-25

Coral reefs are threatened by climate change as coral-algal symbioses are currently living close to their upper thermal limits. The resilience of the algal partner plays a key role in determining the thermal tolerance of the coral holobiont and therefore, understanding the acclimatory limits of present day coral-algal symbioses is fundamental to forecasting corals' responses to climate change. This study characterised the symbiont community in a highly variable and thermally extreme (Max = 37.5 °C, Min = 16.8 °C) lagoon located in the southern Persian/Arabian Gulf using next generation sequencing of ITS2 amplicons. Despite experiencing extreme temperatures, severe bleaching and many factors that would be expected to promote the presence of, or transition to clade D dominance, the symbiont communities of the lagoon remain dominated by the C3 variant, Symbiodinium thermophilum. The stability of this symbiosis across multiple genera with different means of symbiont transmission highlights the importance of Symbiodinium thermophilum for corals living at the acclimatory limits of modern day corals. Corals in this extreme environment did not undergo adaptive bleaching, suggesting they are living at the edge of their acclimatory potential and that this valuable source of thermally tolerant genotypes may be lost in the near future under climate change.

Professional musicians with craniomandibular dysfunctions treated with oral splints.

PubMed

Steinmetz, Anke; Ridder, Paul H; Methfessel, Götz; Muche, Burkhard

2009-10-01

Craniomandibular dysfunction (CMD) symptoms occur frequently in violin/viola and wind players and can be associated with pain in the neck, shoulders and arm. In the current study, the effect of oral splint treatment of CMD on reducing pain and symptoms especially in these areas was investigated. Thirty (30) musicians undergoing CMD treatment with oral splints participated in this study. They completed a questionnaire that addressed CMD symptoms, localization of pain, and subjective changes in symptoms. Pain in the shoulder and/or upper extremity was the most frequent symptom reported by 83% of subjects, followed by neck pain (80%) and pain in the teeth/TMJ regions (63%). Treatment with oral splints contributed to a significant decrease in neck pain in 91%, teeth/TMJ pain in 83%, and shoulder and upper extremity pain in 76% of the musicians. Eighty percent (80%) of the patients reported improvement of their predominant symptoms. CMD can be a potential cause for pain in the neck, shoulders, and upper extremities of musicians. It is paramount that musicians with musculoskeletal problems be examined for CMD symptoms. Treatment with oral splints seems to be valuable. Further prospective, randomized controlled studies are necessary to confirm efficacy of oral splint treatment in CMD-associated pain and problems in the neck, shoulder, and the upper extremities in musicians.

A Novel Denitrifying Extreme Halophile That Grows in a Simple Mineral Salts Medium

NASA Technical Reports Server (NTRS)

Hochstein, L. I.; Oremland, R. S.; Gherna, R.; Cote, R.; Chang, Sherwood (Technical Monitor)

1995-01-01

An extremely halophilic bacterium (strain CH-1) was isolated from a saltern adjacent to San Francisco Bay. It grew in a mineral salts medium with ammonium and glucose as sole sources of nitrogen and carbon as well as energy, respectively Cells lysed at less than 10% NaCl and growth was most rapid in medium containing 20% NaCl. Cells were pieomorphic ranging from disc to ovoid-shaved and used a variety of carbohydrates as sole carbon sources. the utilization of certain carbon sources was controlled by temperature with some used at 37 degrees but not 45 C. CH-1 grew between 30 degrees and 50 C with the optimum at 45 C in the presence of 20% NaCl. CH-1 contained 2,3-di-O-isoprenyl glcerol diethers and was sensitive to aphidicofin. The major polar lipid was glucosyl-mannosyl-alucosyl diether, which is diagnostic of the Haloarcula. Thus CH-1 is an extreme halophile and a member of this genus. Among the novel characteristics of this organism was its ability to grow anaerobically in synthetic medium when nitrate was present which was only reduced to nitrous oxide. This organism should prove useful for studying denitrification and carbohydrate metabolism in the extreme halophiles; and to be a valuable resource for generic studies.

Efficacy of a 3 month training program on the jump-landing technique in jump-landing sports. Design of a cluster randomized controlled trial

PubMed Central

2010-01-01

Background With the relatively high rate of injuries to the lower extremity due to jump-landing movement patterns and the accompanied high costs, there is need for determining potential preventive programs. A program on the intervention of jump-landing technique is possibly an important preventative measure since it appeared to reduce the incidence of lower extremity injuries. In real life situations, amateur sports lack the infrastructure and funds to have a sports physician or therapist permanently supervising such a program. Therefore the current prevention program is designed so that it could be implemented by coaches alone. Objective The objective of this randomized controlled trial is to evaluate the effect of a coach supervised intervention program targeting jump-landing technique on the incidence of lower extremity injuries. Methods Of the 110 Flemish teams of the elite division, 24 teams are included and equally randomized to two study groups. An equal selection of female and male teams with allocation to intervention and control group is obtained. The program is a modification of other prevention programs previously proven to be effective. All exercises in the current program are adjusted so that a more progressive development in the exercise is presented. Both the control and intervention group continue with their normal training routine, while the intervention group carries out the program on jump-landing technique. The full intervention program has a duration of three months and is performed 2 times a week during warm-up (5-10 min). Injuries are registered during the entire season. Discussion The results of this study can give valuable information on the effect of a coach supervised intervention program on jump-landing technique and injury occurrence. Results will become available in 2011. Trial registration Trial registration number: NTR2560 PMID:21144030

The Total Ozone Series of Arosa: History, Homogenization and new results using statistical extreme value theory

NASA Astrophysics Data System (ADS)

Staehelin, J.; Rieder, H. E.; Maeder, J. A.; Ribatet, M.; Davison, A. C.; Stübi, R.

2009-04-01

Atmospheric ozone protects the biota living at the Earth's surface from harmful solar UV-B and UV-C radiation. The global ozone shield is expected to gradually recover from the anthropogenic disturbance of ozone depleting substances (ODS) in the coming decades. The stratospheric ozone layer at extratropics might significantly increase above the thickness of the chemically undisturbed atmosphere which might enhance ozone concentrations at the tropopause altitude where ozone is an important greenhouse gas. At Arosa, a resort village in the Swiss Alps, total ozone measurements started in 1926 leading to the longest total ozone series of the world. One Fery spectrograph and seven Dobson spectrophotometers were operated at Arosa and the method used to homogenize the series will be presented. Due to its unique length the series allows studying total ozone in the chemically undisturbed as well as in the ODS loaded stratosphere. The series is particularly valuable to study natural variability in the period prior to 1970, when ODS started to affect stratospheric ozone. Concepts developed by extreme value statistics allow objective definitions of "ozone extreme high" and "ozone extreme low" values by fitting the (daily mean) time series using the Generalized Pareto Distribution (GPD). Extreme high ozone events can be attributed to effects of ElNino and/or NAO, whereas in the chemically disturbed stratosphere high frequencies of extreme low total ozone values simultaneously occur with periods of strong polar ozone depletion (identified by statistical modeling with Equivalent Stratospheric Chlorine times Volume of Stratospheric Polar Clouds) and volcanic eruptions (such as El Chichon and Pinatubo).

Prevention of AIDS and living together with an HIV-infected patient.

PubMed

Fahik, F T; Reichert, M C; Gabriel, R; Marin, H F

1995-01-01

In Brazil, approximately 45 thousand cases had been reported until the end of 1993, with an estimated 50% underreport. According to the Ministry of Health, until the year 2,000 from 2 to 8 million Brazilians citizens will be infected with HIV. The basic aspect of the educational campaigns regarding AIDS does not refer only to information on forms of transmission and prevention measures, but also attempts to fight against the mystification and the enormous resistance of the public to definitely accept the fact that transmission does not occur by simple means such as having a drink from the same glass, independently of its socioeconomic and cultural level. In addition to the lack of information, prejudice and discrimination appear strongly rooted in the population to the point of a tendency of social and effective rejection of the HIV-infected patient. Fighting against prejudice, against which there is also no vaccine, is a task as gigantic as fighting against the virus. For both, investments in education of and information to the population in general, is very important. Development of a software which would fulfill the function of explaining, and providing the correct information about AIDS, would be extremely valuable for any part of the society and could also be used as a complementary element by health professionals. The objective was to develop an interactive software in order to demonstrate prevention measures and universal precaution in AIDS; to inform about the necessary care to people that are living together an HIV-infected patient. To develop this software with animation and elucidating text regarding AIDS for the general population, we are using the Storyboard live to be run in Windows environment.

The use of semi-structured interviews for collection of qualitative and quantitative data in hydrological studies

NASA Astrophysics Data System (ADS)

O'Keeffe, Jimmy; Buytaert, Wouter; Mijic, Ana; Brozovic, Nicholas

2015-04-01

To build an accurate, robust understanding of the environment, it is important to not only collect information describing its physical characteristics, but also the drivers which influence it. As environmental change, from increasing CO2 levels to decreasing water levels, is often heavily influenced by human activity, gathering information on anthropogenic as well as environmental variables is extremely important. This can mean collecting qualitative, as well as quantitative information. In reality studies are often bound by financial and time constraints, limiting the depth and detail of the research. It is up to the researcher to determine what the best methodology to answer the research questions is likely to be. Here we present a methodology of collecting qualitative and quantitative information in tandem for hydrological studies through the use of semi-structured interviews. This is applied to a case study in two districts of Uttar Pradesh, North India, one of the most intensely irrigated areas of the world. Here, decreasing water levels exacerbated by unchecked water abstraction, an expanding population and government subsidies, have put the long term resilience of the farming population in doubt. Through random selection of study locations, combined with convenience sampling of the participants therein, we show how the data collected can provide valuable insight into the drivers which have led to the current water scenario. We also show how reliable quantitative information can, using the same methodology, be effectively and efficiently extracted for modelling purposes, which along with developing an understanding of the characteristics of the environment is vital in coming up with realistic and sustainable solutions for water resource management in the future.

International use of an academic nephrology World Wide Web site: from medical information resource to business tool.

PubMed

Abbott, Kevin C; Oliver, David K; Boal, Thomas R; Gadiyak, Grigorii; Boocks, Carl; Yuan, Christina M; Welch, Paul G; Poropatich, Ronald K

2002-04-01

Studies of the use of the World Wide Web to obtain medical knowledge have largely focused on patients. In particular, neither the international use of academic nephrology World Wide Web sites (websites) as primary information sources nor the use of search engines (and search strategies) to obtain medical information have been described. Visits ("hits") to the Walter Reed Army Medical Center (WRAMC) Nephrology Service website from April 30, 2000, to March 14, 2001, were analyzed for the location of originating source using Webtrends, and search engines (Google, Lycos, etc.) were analyzed manually for search strategies used. From April 30, 2000 to March 14, 2001, the WRAMC Nephrology Service website received 1,007,103 hits and 12,175 visits. These visits were from 33 different countries, and the most frequent regions were Western Europe, Asia, Australia, the Middle East, Pacific Islands, and South America. The most frequent organization using the site was the military Internet system, followed by America Online and automated search programs of online search engines, most commonly Google. The online lecture series was the most frequently visited section of the website. Search strategies used in search engines were extremely technical. The use of "robots" by standard Internet search engines to locate websites, which may be blocked by mandatory registration, has allowed users worldwide to access the WRAMC Nephrology Service website to answer very technical questions. This suggests that it is being used as an alternative to other primary sources of medical information and that the use of mandatory registration may hinder users from finding valuable sites. With current Internet technology, even a single service can become a worldwide information resource without sacrificing its primary customers.

The impact of real-time and predictive traffic information on travelers' behavior on the I-4 corridor. Final report.

DOT National Transportation Integrated Search

2003-07-01

Real time and predicted traffic information plays a key role in the successful implementation of advanced traveler information systems (ATIS) and advance traffic management systems (ATMS). Traffic information is essentially valuable to both transport...

Tradeoffs in Risk and Return of Financial Hedging Solutions to Mitigate Drought-Related Financial Risks for Water Utilities

NASA Astrophysics Data System (ADS)

Baum, R.; Characklis, G. W.

2016-12-01

Financial hedging solutions have been examined as tools for effectively mitigating water scarcity related financial risks for water utilities, and have become more prevalent as conservation (resulting in reduced revenues) and water transfers (resulting in increased costs) play larger roles in drought management. Individualized financial contracts (i.e. designed for a single utility) provide evidence of the potential benefits of financial hedging. However, individualized contracts require substantial time and information to develop, limiting their widespread implementation. More generalized contracts have also shown promise, and would allow the benefits of risk pooling to be more effectively realized, resulting in less expensive contracts. Risk pooling reduces the probability of an insurer making payouts that deviate significantly from the mean, but given that the financial risks of drought are spatially correlated amongst utilities, these more extreme "fat tail" risks remain. Any group offering these hedging contracts, whether a third-party insurer or a "mutual" comprised of many utilities, will need to balance the costs (i.e. additional risk) and benefits (i.e. returns) of alternative approaches to managing the extreme risks (e.g. through insurance layers). The balance of these different approaches will vary depending on the risk pool being considered, including the number, size and exposure of the participating utilities. This work first establishes a baseline of the tradeoffs between risk and expected return in insuring against the financial risks of water scarcity without alternative hedging approaches for water utilities across all climate divisions of the United States. Then various scenarios are analyzed to provide insight into how to maximize returns for risk pooling portfolios at various risk levels through balancing different insurance layers and hedging approaches. This analysis will provide valuable information for designing optimal financial risk management strategies for water utilities across the United States.

Forensic Disaster Analysis in Near-real Time

NASA Astrophysics Data System (ADS)

Kunz, Michael; Zschau, Jochen; Wenzel, Friedemann; Khazai, Bijan; Kunz-Plapp, Tina; Trieselmann, Werner

2014-05-01

The impacts of extreme hydro-meteorological and geophysical events are controlled by various factors including severity of the event (intensity, duration, spatial extent), amplification with other phenomena (multihazard or cascading effects), interdependencies of technical systems and infrastructure, preparedness and resilience of the society. The Center for Disaster Management and Risk Reduction Technology (CEDIM) has adopted the comprehensive understanding of disasters and develops methodologies of near real-time FDA as a complementing component of the FORIN program of IRDR. The new research strategy 'Near Real-Time Forensic Disaster Analysis (FDA)' aims at scrutinizing disasters closely with a multi-disciplinary approach in order to assess the various aspects of disasters and to identify mechanisms most relevant for an extreme event to become a disaster (e.g., causal loss analysis). Recent technology developments - which have opened unprecedented opportunities for real-time hazard, vulnerability and loss assessment - are used for analyzing disasters and their impacts in combination with databases of historical events. The former covers modern empirical and analytical methods available in engineering and remote sensing for rapid impact assessments, rapid information extraction from crowd sourcing as well as rapid assessments of socio-economic impacts and economic losses. The event-driven science-based assessments of CEDIM are compiled based on interdisciplinary expertise and include the critical evaluation, assessment, validation, and quantification of an event. An important component of CEDIM's FDA is the near real-time approach which is expected to significantly speed up our understanding of natural disasters and be used to provide timely, relevant and valuable information to various user groups within their respective contexts. Currently, CEDIM has developed models and methodologies to assess different types of hazard. These approaches were applied to several disasters including, for example, Super Typhoon Haiyan/Yolanda (Nov. 2013), Central European Floods (June 2013), Hurricane Sandy (Oct. 2012), US Droughts (Summer 2012), or Typhoon Saola in Taiwan and Philippines (July 2012).

76 FR 23540 - Proposed Information Collection; Comment Request; Annual Survey of Manufactures

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... provides valuable information to private companies, research organizations, and trade associations... DEPARTMENT OF COMMERCE Census Bureau Proposed Information Collection; Comment Request; Annual... information collections, as required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506...

Overcorrection for Social-Categorization Information Moderates Impact Bias in Affective Forecasting.

PubMed

Lau, Tatiana; Morewedge, Carey K; Cikara, Mina

2016-10-01

Plural societies require individuals to forecast how others-both in-group and out-group members-will respond to gains and setbacks. Typically, correcting affective forecasts to include more relevant information improves their accuracy by reducing their extremity. In contrast, we found that providing affective forecasters with social-category information about their targets made their forecasts more extreme and therefore less accurate. In both political and sports contexts, forecasters across five experiments exhibited greater impact bias for both in-group and out-group members (e.g., a Democrat or Republican) than for unspecified targets when predicting experiencers' responses to positive and negative events. Inducing time pressure reduced the extremity of forecasts for group-labeled but not unspecified targets, which suggests that the increased impact bias was due to overcorrection for social-category information, not different intuitive predictions for identified targets. Finally, overcorrection was better accounted for by stereotypes than by spontaneous retrieval of extreme group exemplars.

In praise of middle managers.

PubMed

Huy, Q N

2001-09-01

Middle managers have often been cast as dinosaurs. Has-beens. Mediocre managers and intermediaries who defend the status quo instead of supporting others' attempts to change organizations for the better. An INSEAD professor has examined this interesting breed of manager--in particular, middle managers' roles during periods of radical organizational change. His findings will surprise many. Middle managers, it turns out, make valuable contributions to the realization of radical change at companies--contributions that go largely unrecognized by most senior executives. Quy Nguyen Huy says these contributions occur in four major areas. First, middle managers often have good entrepreneurial ideas that they are able and willing to realize--if only they can get a hearing. Second, they're far better than most senior executives at leveraging the informal networks at companies that make substantive, lasting change. Because they've worked their way up the corporate ladder, middle managers' networks run deep. Third, they stay attuned to employees' emotional needs during organizational change, thereby maintaining the transformation's momentum. And finally, they manage the tension between continuity and change--they keep the organization from falling into extreme inertia or extreme chaos. The author examines each of these strengths, citing real-world examples culled from his research. Of course, not every middle manager in an organization is a paragon of entrepreneurial vigor and energy, Huy acknowledges. But cavalierly dismissing the roles that middle managers play--and carelessly reducing their ranks--will drastically diminish senior managers' chances of realizing radical change at their companies. Indeed, middle managers may be the most effective allies of corner office executives when it's time to make major changes in businesses.

Halophilic Bacteria as a Source of Novel Hydrolytic Enzymes

PubMed Central

de Lourdes Moreno, María; Pérez, Dolores; García, María Teresa; Mellado, Encarnación

2013-01-01

Hydrolases constitute a class of enzymes widely distributed in nature from bacteria to higher eukaryotes. The halotolerance of many enzymes derived from halophilic bacteria can be exploited wherever enzymatic transformations are required to function under physical and chemical conditions, such as in the presence of organic solvents and extremes in temperature and salt content. In recent years, different screening programs have been performed in saline habitats in order to isolate and characterize novel enzymatic activities with different properties to those of conventional enzymes. Several halophilic hydrolases have been described, including amylases, lipases and proteases, and then used for biotechnological applications. Moreover, the discovery of biopolymer-degrading enzymes offers a new solution for the treatment of oilfield waste, where high temperature and salinity are typically found, while providing valuable information about heterotrophic processes in saline environments. In this work, we describe the results obtained in different screening programs specially focused on the diversity of halophiles showing hydrolytic activities in saline and hypersaline habitats, including the description of enzymes with special biochemical properties. The intracellular lipolytic enzyme LipBL, produced by the moderately halophilic bacterium Marinobacter lipolyticus, showed advantages over other lipases, being an enzyme active over a wide range of pH values and temperatures. The immobilized LipBL derivatives obtained and tested in regio- and enantioselective reactions, showed an excellent behavior in the production of free polyunsaturated fatty acids (PUFAs). On the other hand, the extremely halophilic bacterium, Salicola marasensis sp. IC10 showing lipase and protease activities, was studied for its ability to produce promising enzymes in terms of its resistance to temperature and salinity. PMID:25371331

Digital PCR analysis of circulating nucleic acids.

PubMed

Hudecova, Irena

2015-10-01

Detection of plasma circulating nucleic acids (CNAs) requires the use of extremely sensitive and precise methods. The commonly used quantitative real-time polymerase chain reaction (PCR) poses certain technical limitations in relation to the precise measurement of CNAs whereas the costs of massively parallel sequencing are still relatively high. Digital PCR (dPCR) now represents an affordable and powerful single molecule counting strategy to detect minute amounts of genetic material with performance surpassing many quantitative methods. Microfluidic (chip) and emulsion (droplet)-based technologies have already been integrated into platforms offering hundreds to millions of nanoliter- or even picoliter-scale reaction partitions. The compelling observations reported in the field of cancer research, prenatal testing, transplantation medicine and virology support translation of this technology into routine use. Extremely sensitive plasma detection of rare mutations originating from tumor or placental cells among a large background of homologous sequences facilitates unraveling of the early stages of cancer or the detection of fetal mutations. Digital measurement of quantitative changes in plasma CNAs associated with cancer or graft rejection provides valuable information on the monitoring of disease burden or the recipient's immune response and subsequent therapy treatment. Furthermore, careful quantitative assessment of the viral load offers great value for effective monitoring of antiviral therapy for immunosuppressed or transplant patients. The present review describes the inherent features of dPCR that make it exceptionally robust in precise and sensitive quantification of CNAs. Moreover, I provide an insight into the types of potential clinical applications that have been developed by researchers to date. Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Information Superiority generated through proper application of Geoinformatics

NASA Astrophysics Data System (ADS)

Teichmann, F.

2012-04-01

Information Superiority generated through proper application of Geoinformatics Information management and especially geoscience information delivery is a very delicate task. If it is carried out successfully, geoscientific data will provide the main foundation of Information Superiority. However, improper implementation of geodata generation, assimilation, distribution or storage will not only waste valuable resources like manpower or money, but could also give rise to crucial deficiency in knowledge and might lead to potentially extremely harmful disasters or wrong decisions. Comprehensive Approach, Effect Based Operations and Network Enabled Capabilities are the current buzz terms in the security regime. However, they also apply to various interdisciplinary tasks like catastrophe relief missions, civil task operations or even in day to day business operations where geo-science data is used. Based on experience in the application of geoscience data for defence applications the following procedure or tool box for generating geodata should lead to the desired information superiority: 1. Understand and analyse the mission, the task and the environment for which the geodata is needed 2. Carry out a Information Exchange Requirement between the user or customer and the geodata provider 3. Implementation of current interoperability standards and a coherent metadata structure 4. Execute innovative data generation, data provision, data assimilation and data storage 5. Apply a cost-effective and reasonable data life cycle 6. Implement IT security by focusing of the three pillar concepts Integrity, Availability and Confidentiality of the critical data 7. Draft and execute a service level agreement or a memorandum of understanding between the involved parties 8. Execute a Continuous Improvement Cycle These ideas from the IT world should be transferred into the geoscience community and applied in a wide set of scenarios. A standardized approach of how to generate, provide, handle, distribute and store geodata will can reduce costs, strengthen the ties between service costumer and geodata provider and improve the contribution geoscience can make for achieving information superiority for decision makers.

Test Expectancy and Memory for Important Information

PubMed Central

Middlebrooks, Catherine D.; Murayama, Kou; Castel, Alan D.

2016-01-01

Prior research suggests that learners study and remember information differently depending upon the type of test they expect to later receive. The current experiments investigate how testing expectations impact the study of and memory for valuable information. Participants studied lists of words ranging in value from 1–10 points with the goal being to maximize their score on a later memory test. Half of the participants were told to expect a recognition test after each list, while the other half were told to expect a recall test. After several lists of receiving tests congruent with expectations, participants studying for a recognition test instead received an unexpected recall test. In Experiment 1, participants who had studied for a recognition test recalled less of the valuable information than participants anticipating the recall format. These participants continued to attend less to item value on future (expected) recall tests than participants who had only ever experienced recall testing. When the recognition tests were made more demanding in Experiment 2, value-based recall improved relative to Experiment 1: though memory for the valuable information remained superior when participants studied with the expectation of having to recall the information, there were no longer significant differences after accounting for recall testing experience. Thus, recall-based testing encouraged strategic, value-based encoding and enhanced retrieval of important information, while recognition testing in some cases limited value-based study and memory. These results extend prior work concerning the impact of testing expectations on memory, offering further insight into how people study important information. PMID:28095010

All-Direction Random Routing for Source-Location Privacy Protecting against Parasitic Sensor Networks

PubMed Central

Wang, Na; Zeng, Jiwen

2017-01-01

Wireless sensor networks are deployed to monitor the surrounding physical environments and they also act as the physical environments of parasitic sensor networks, whose purpose is analyzing the contextual privacy and obtaining valuable information from the original wireless sensor networks. Recently, contextual privacy issues associated with wireless communication in open spaces have not been thoroughly addressed and one of the most important challenges is protecting the source locations of the valuable packages. In this paper, we design an all-direction random routing algorithm (ARR) for source-location protecting against parasitic sensor networks. For each package, the routing process of ARR is divided into three stages, i.e., selecting a proper agent node, delivering the package to the agent node from the source node, and sending it to the final destination from the agent node. In ARR, the agent nodes are randomly chosen in all directions by the source nodes using only local decisions, rather than knowing the whole topology of the networks. ARR can control the distributions of the routing paths in a very flexible way and it can guarantee that the routing paths with the same source and destination are totally different from each other. Therefore, it is extremely difficult for the parasitic sensor nodes to trace the packages back to the source nodes. Simulation results illustrate that ARR perfectly confuses the parasitic nodes and obviously outperforms traditional routing-based schemes in protecting source-location privacy, with a marginal increase in the communication overhead and energy consumption. In addition, ARR also requires much less energy than the cloud-based source-location privacy protection schemes. PMID:28304367

Quantifying highly efficient incoherent energy transfer in perylene-based multichromophore arrays.

PubMed

Webb, James E A; Chen, Kai; Prasad, Shyamal K K; Wojciechowski, Jonathan P; Falber, Alexander; Thordarson, Pall; Hodgkiss, Justin M

2016-01-21

Multichromophore perylene arrays were designed and synthesized to have extremely efficient resonance energy transfer. Using broadband ultrafast photoluminescence and transient absorption spectroscopies, transfer timescales of approximately 1 picosecond were resolved, corresponding to efficiencies of up to 99.98%. The broadband measurements also revealed spectra corresponding to incoherent transfer between localized states. Polarization resolved spectroscopy was used to measure the dipolar angles between donor and acceptor chromophores, thereby enabling geometric factors to be fixed when assessing the validity of Förster theory in this regime. Förster theory was found to predict the correct magnitude of transfer rates, with measured ∼2-fold deviations consistent with the breakdown of the point-dipole approximation at close approach. The materials presented, along with the novel methods for quantifying ultrahigh energy transfer efficiencies, will be valuable for applications demanding extremely efficient energy transfer, including fluorescent solar concentrators, optical gain, and photonic logic devices.

Foundations of Full Text Electronic Information Delivery Systems. Implications for Information Professionals.

ERIC Educational Resources Information Center

Kibirige, Harry M.

Information has become an increasingly valuable commodity. Access to full-text information, containing text, images, and in some cases, sound, is becoming vital to decision-making for organizations as well as individuals. The book covers the following topics: (1) the information marketplace in a cyberculture; (2) the telecommunications foundation…

Analyzing jobs for redesign decisions.

PubMed

Conn, V S; Davis, N K; Occena, L G

1996-01-01

Job analysis, the collection and interpretation of information that describes job behaviors and activities performed by occupants of jobs, can provide nurse administrators with valuable information for redesigning effective and efficient systems of care.

Use of Remote Sensing Products for the SERVIR Project

NASA Technical Reports Server (NTRS)

Policelli, Frederick S.

2010-01-01

The United Nations University (UNU) estimates that floods presently impacts greater than 520 million people per year worldwide, resulting in up to 25,000 annual deaths, extensive homelessness, disaster-induced disease, crop and livestock damage, famine, and other serious harm. Meanwhile, aid agencies such as the International Federation of Red Cross and Red Crescent Societies (IFRC) are increasingly seeking better information concerning flood hazards in order to plan for and help mitigate the effects of damaging floods. There is fertile ground to continue development of better remote sensing and modeling techniques to help manage flood related disasters. Disaster management and humanitarian aid organizations need accurate and timely information for making decisions regarding deployment of relief teams and emergency supplies during major floods. Flood maps based on the use of satellite data have proven extremely valuable to such organizations for identifying the location, extent, and severity of these events. However, despite extraordinary efforts on the part of remote sensing data providers to rapidly deliver such maps, there is typically a delay of several days or even weeks from the on-set of flooding until such maps are available to the disaster management community. This paper summarizes efforts at NASA to address this problem through development of an integrated and automated process of a) flood forecasting b) flood detection, c) satellite data acquisition, d) rapid flood mapping and distribution, and e) validation of flood forecasting and detection products.

Neutron Scattering in Chemistry: Experiments, Models and Statistical Description of Physical Phenomena

NASA Astrophysics Data System (ADS)

Ramirez Cuesta, Timmy

Incoherent inelastic neutron scattering spectroscopy is a very powerful technique that requires the use of ab-initio models to interpret the experimental data. Albeit not exact the information obtained from the models gives very valuable insight into the dynamics of atoms in solids and molecules, that, in turn, provides unique access to the vibrational density of states. It is extremely sensitive to hydrogen since the neutron cross section of hydrogen is the largest of all chemical elements. Hydrogen, being the lightest element highlights quantum effects more pronounced than the rest of the elements.In the case of non-crystalline or disordered materials, the models provide partial information and only a reduced sampling of possible configurations can be done at the present. With very large computing power, as exascale computing will provide, a new opportunity arises to study these systems and introduce a description of statistical configurations including energetics and dynamics characterization of configurational entropy. As part of the ICE-MAN project, we are developing the tools to manage the workflows, visualize and analyze the results. To use state of the art computational methods and most neutron scattering that using atomistic models for interpretation of experimental data This work is supported by the Laboratory Directed Research and Development (LDRD 8237) program of the UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy.

Pseudonymisation of radiology data for research purposes

NASA Astrophysics Data System (ADS)

Noumeir, Rita; Lemay, Alain; Lina, Jean-Marc

2005-04-01

Medical image processing methods and algorithms, developed by researchers, need to be validated and tested. Test data should ideally be real clinical data especially when that clinical data is varied and exists in large volume. In nowadays, clinical data is accessible electronically and has important value for researchers. However, the usage of clinical data for research purposes should respect data confidentiality, patient right to privacy and the patient consent. In fact, clinical data is nominative given that it contains information about the patient such as name, age and identification number. Evidently, clinical data should be de-identified to be exported to research databases. However, the same patient is usually followed during a long period of time. The disease progression and the diagnostic evolution represent extremely valuable information for researchers, as well. Our objective is to build a research database from de-identified clinical data while enabling the database to be easily incremented by exporting new pseudonymous data, acquired over a long period of time. Pseudonymisation is data de-identification such that data belonging to the same individual in the clinical environment bear the same relation to each other in the de-identified research version. In this paper, we propose a software architecture that enables the implementation of a research database that can be incremented in time. We also evaluate its security and discuss its security pitfalls.

Water quality modelling of Jadro spring.

PubMed

Margeta, J; Fistanic, I

2004-01-01

Management of water quality in karst is a specific problem. Water generally moves very fast by infiltration processes but far more by concentrated flows through fissures and openings in karst. This enables the entire surface pollution to be transferred fast and without filtration into groundwater springs. A typical example is the Jadro spring. Changes in water quality at the spring are sudden, but short. Turbidity as a major water quality problem for the karst springs regularly exceeds allowable standards. Former practice in problem solving has been reduced to intensive water disinfection in periods of great turbidity without analyses of disinfection by-products risks for water users. The main prerequisite for water quality control and an optimization of water disinfection is the knowledge of raw water quality and nature of occurrence. The analysis of monitoring data and their functional relationship with hydrological parameters enables establishment of a stochastic model that will help obtain better information on turbidity in different periods of the year. Using the model a great number of average monthly and extreme daily values are generated. By statistical analyses of these data possibility of occurrence of high turbidity in certain months is obtained. This information can be used for designing expert system for water quality management of karst springs. Thus, the time series model becomes a valuable tool in management of drinking water quality of the Jadro spring.

Analysis of extreme precipitation characteristics in low mountain areas based on three-dimensional copulas—taking Kuandian County as an example

NASA Astrophysics Data System (ADS)

Wang, Cailin; Ren, Xuehui; Li, Ying

2017-04-01

We defined the threshold of extreme precipitation using detrended fluctuation analysis based on daily precipitation during 1955-2013 in Kuandian County, Liaoning Province. Three-dimensional copulas were introduced to analyze the characteristics of four extreme precipitation factors: the annual extreme precipitation day, extreme precipitation amount, annual average extreme precipitation intensity, and extreme precipitation rate of contribution. The results show that (1) the threshold is 95.0 mm, extreme precipitation events generally occur 1-2 times a year, the average extreme precipitation intensity is 100-150 mm, and the extreme precipitation amount is 100-270 mm accounting for 10 to 37 % of annual precipitation. (2) The generalized extreme value distribution, extreme value distribution, and generalized Pareto distribution are suitable for fitting the distribution function for each element of extreme precipitation. The Ali-Mikhail-Haq (AMH) copula function reflects the joint characteristics of extreme precipitation factors. (3) The return period of the three types has significant synchronicity, and the joint return period and co-occurrence return period have long delay when the return period of the single factor is long. This reflects the inalienability of extreme precipitation factors. The co-occurrence return period is longer than that of the single factor and joint return period. (4) The single factor fitting only reflects single factor information of extreme precipitation but is unrelated to the relationship between factors. Three-dimensional copulas represent the internal information of extreme precipitation factors and are closer to the actual. The copula function is potentially widely applicable for the multiple factors of extreme precipitation.

ERTS program of the US Army Corps of Engineers. [water resources

NASA Technical Reports Server (NTRS)

Jarman, J. W.

1974-01-01

The Army Corps of Engineers research and development efforts associated with the ERTS Program are confined to applications of investigation, design, construction, operation, and maintenance of water resource projects. Problems investigated covered: (1) resource inventory; (2) environmental impact; (3) pollution monitoring; (4) water circulation; (5) sediment transport; (6) data collection systems; (7) engineering; and (8) model verification. These problem areas were investigated in relation to bays, reservoirs, lakes, rivers, coasts, and regions. ERTS-1 imagery has been extremely valuable in developing techniques and is now being used in everyday applications.

Rehabilitation centers: marketing analysis and future challenges.

PubMed

Chandra, Ashish; Stroube, William B; Willis, William K

2014-01-01

A rehabilitation center is another form of health care organization that specializes in providing care for particular conditions of patients. Patients admitted in rehab centers range from being accident victims to those suffering with a specific illness. These organizations are becoming extremely valuable in providing patient care services. However, they have not marketed themselves as aggressively as other health care organizations. This article provides an insight regarding rehab centers and examines marketing issues using a SWOT (strengths, weaknesses, opportunities, and threats) analysis. It further provides some future prospects and challenges for marketers of these organizations.

Flood damage assessment using computer-assisted analysis of color infrared photography

USGS Publications Warehouse

Anderson, William H.

1978-01-01

Use of digitized aerial photographs for flood damage assessment in agriculture is new and largely untested. However, under flooding circumstances similar to the 1975 Red River Valley flood, computer-assisted techniques can be extremely useful, especially if detailed crop damage estimates are needed within a relatively short period of time.Airphoto interpretation techniques, manual or computer-assisted, are not intended to replace conventional ground survey and sampling procedures. But their use should be considered a valuable addition to the tools currently available for assessing agricultural flood damage.

The post-stroke rehabilitation outcomes project.

PubMed

Jette, Alan M

2005-12-01

Jette AM. The Post-Stroke Rehabilitation Outcomes Project. The Post-Stroke Rehabilitation Outcomes Project (PSROP) provides an important example of the value of observational study designs in rehabilitation. The strength of the PSROP lies in the extensive, in-depth data collected on the specific rehabilitation interventions provided to patients and their relationship to short-term outcomes as well as the wide generalizability of the study's findings. Although providing valuable insights, one has to be extremely cautious in drawing direct practice recommendations from the PSROP given several internal validity threats inherent in the PSROP design.

[Ultrasound scattering properties of Albunex microspheres].

PubMed

Takamoto, T; Shiina, T

1998-04-01

In Japan, clinical and basic investigations of Albunex were started from 1989, and was firstly approved by the government as a commercially available contrast agent for the cardiovascular disorders. Although it has recently evacuated from the market, its acoustic properties proven by the many investigators were valuable for preparation of the second generation of contrast agents. Therefore, we summarized our data of the ultrasonic properties of Albunex both in vitro and experimental dog studies using RF signals. In conclusion, Albunex was a extremely sensitive blood flow tracer in evaluating intracardiac blood flow as well as intramyocardial perfusion.

Assessing Regional Scale Variability in Extreme Value Statistics Under Altered Climate Scenarios

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brunsell, Nathaniel; Mechem, David; Ma, Chunsheng

Recent studies have suggested that low-frequency modes of climate variability can significantly influence regional climate. The climatology associated with extreme events has been shown to be particularly sensitive. This has profound implications for droughts, heat waves, and food production. We propose to examine regional climate simulations conducted over the continental United States by applying a recently developed technique which combines wavelet multi–resolution analysis with information theory metrics. This research is motivated by two fundamental questions concerning the spatial and temporal structure of extreme events. These questions are 1) what temporal scales of the extreme value distributions are most sensitive tomore » alteration by low-frequency climate forcings and 2) what is the nature of the spatial structure of variation in these timescales? The primary objective is to assess to what extent information theory metrics can be useful in characterizing the nature of extreme weather phenomena. Specifically, we hypothesize that (1) changes in the nature of extreme events will impact the temporal probability density functions and that information theory metrics will be sensitive these changes and (2) via a wavelet multi–resolution analysis, we will be able to characterize the relative contribution of different timescales on the stochastic nature of extreme events. In order to address these hypotheses, we propose a unique combination of an established regional climate modeling approach and advanced statistical techniques to assess the effects of low-frequency modes on climate extremes over North America. The behavior of climate extremes in RCM simulations for the 20th century will be compared with statistics calculated from the United States Historical Climatology Network (USHCN) and simulations from the North American Regional Climate Change Assessment Program (NARCCAP). This effort will serve to establish the baseline behavior of climate extremes, the validity of an innovative multi–resolution information theory approach, and the ability of the RCM modeling framework to represent the low-frequency modulation of extreme climate events. Once the skill of the modeling and analysis methodology has been established, we will apply the same approach for the AR5 (IPCC Fifth Assessment Report) climate change scenarios in order to assess how climate extremes and the the influence of lowfrequency variability on climate extremes might vary under changing climate. The research specifically addresses the DOE focus area 2. Simulation of climate extremes under a changing climate. Specific results will include (1) a better understanding of the spatial and temporal structure of extreme events, (2) a thorough quantification of how extreme values are impacted by low-frequency climate teleconnections, (3) increased knowledge of current regional climate models ability to ascertain these influences, and (4) a detailed examination of the how the distribution of extreme events are likely to change under different climate change scenarios. In addition, this research will assess the ability of the innovative wavelet information theory approach to characterize extreme events. Any and all of these results will greatly enhance society’s ability to understand and mitigate the regional ramifications of future global climate change.« less

76 FR 38360 - Workshop-Monitoring Changes in Extreme Storm Statistics: State of Knowledge; Notice of Open...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... Changes in Extreme Storm Statistics: State of Knowledge; Notice of Open Public Workshop AGENCY: National... .) SUPPLEMENTARY INFORMATION: This workshop will provide an update to the climate science surrounding extreme... storms. Specific topics include: Severe Thunderstorms (and associated hail and winds), tornadoes, extreme...

Will Biomedical Enhancements Undermine Solidarity, Responsibility, Equality and Autonomy?

PubMed Central

Lev, Ori

2009-01-01

Prominent thinkers such as Jurgen Habermas and Michael Sandel are warning that biomedical enhancements will undermine fundamental political values. Yet, whether biomedical enhancements will undermine such values depends on how biomedical enhancements will function, how they will be administered and to whom. Since only few enhancements are obtainable, it is difficult to tell whether their predictions are sound. Nevertheless, such warnings are extremely valuable. As a society we must, at the very least, be aware of developments that could have harmful consequences. Indeed, if important values would be jeopardized, we should take appropriate measures to protect them. This paper focuses on four central values: solidarity, personal responsibility, equality and autonomy. It delineates the conditions under which biomedical enhancements would undermine these values. It also details the circumstances under which these values would be unaffected by enhancements as well as those under which they would be promoted. Specifying these conditions is valuable; it would enable society to prepare appropriate ethical guidelines and policy responses in advance. PMID:20002073

D.E.E.P. Learning: Promoting Informal STEM Learning through a Popular Gaming Platform

NASA Astrophysics Data System (ADS)

Simms, E.; Rohrlick, D.; Layman, C.; Peach, C. L.; Orcutt, J. A.

2011-12-01

The research and development of educational games, and the study of the educational value of interactive games in general, have lagged far behind efforts for games created for the purpose of entertainment. But evidence suggests that digital simulations and games have the "potential to advance multiple science learning goals, including motivation to learn science, conceptual understanding, science process skills, understanding of the nature of science, scientific discourse and argumentation, and identification with science and science learning." (NRC, 2011). It is also generally recognized that interactive digital games have the potential to promote the development of valuable learning and life skills, including data processing, decision-making, critical thinking, planning, communication and collaboration (Kirriemuir and MacFarlane, 2006). Video games are now played in 67% of American households (ESA, 2010), and across a broad range of ages, making them a potentially valuable tool for Science, Technology, Engineering and Mathematics (STEM) learning among the diverse audiences associated with informal science education institutions (ISEIs; e.g., aquariums, museums, science centers). We are attempting to capitalize on this potential by developing games based on the popular Microsoft Xbox360 gaming platform and the free Microsoft XNA game development kit. The games, collectively known as Deep-sea Extreme Environment Pilot (D.E.E.P.), engage ISEI visitors in the exploration and understanding of the otherwise remote deep-sea environment. Players assume the role of piloting a remotely-operated vehicle (ROV) to explore ocean observing systems and hydrothermal vent environments, and are challenged to complete science-based objectives in order to earn points under timed conditions. The current games are intended to be relatively brief visitor experiences (on the order of several minutes) that support complementary exhibits and programming, and promote interactive visitor experiences. In addition to creating a unique educational product, our efforts are intended to inform the broader understanding of the key elements of a successful STEM-based game experience at an ISEI. Which characteristics of the ISEI environment (e.g., age and cultural diversity, limited time of engagement) are conducive or inhibitive to learning via digital gaming? Which aspects of game design (e.g., challenge, curiosity, fantasy, personal recognition) are most effective at maximizing both learning and enjoyment? We will share our progress and assessment results to date, and discuss the potential benefits and challenges to interactive gaming as a tool to support STEM literacy at ISEIs.

Use of Remote Sensing Data to Enhance NWS Storm Damage Toolkit

NASA Technical Reports Server (NTRS)

Jedlove, Gary J.; Molthan, Andrew L.; White, Kris; Burks, Jason; Stellman, Keith; Smith, Mathew

2012-01-01

In the wake of a natural disaster such as a tornado, the National Weather Service (NWS) is required to provide a very detailed and timely storm damage assessment to local, state and federal homeland security officials. The Post ]Storm Data Acquisition (PSDA) procedure involves the acquisition and assembly of highly perishable data necessary for accurate post ]event analysis and potential integration into a geographic information system (GIS) available to its end users and associated decision makers. Information gained from the process also enables the NWS to increase its knowledge of extreme events, learn how to better use existing equipment, improve NWS warning programs, and provide accurate storm intensity and damage information to the news media and academia. To help collect and manage all of this information, forecasters in NWS Southern Region are currently developing a Storm Damage Assessment Toolkit (SDAT), which incorporates GIS ]capable phones and laptops into the PSDA process by tagging damage photography, location, and storm damage details with GPS coordinates for aggregation within the GIS database. However, this tool alone does not fully integrate radar and ground based storm damage reports nor does it help to identify undetected storm damage regions. In many cases, information on storm damage location (beginning and ending points, swath width, etc.) from ground surveys is incomplete or difficult to obtain. Geographic factors (terrain and limited roads in rural areas), manpower limitations, and other logistical constraints often prevent the gathering of a comprehensive picture of tornado or hail damage, and may allow damage regions to go undetected. Molthan et al. (2011) have shown that high resolution satellite data can provide additional valuable information on storm damage tracks to augment this database. This paper presents initial development to integrate satellitederived damage track information into the SDAT for near real ]time use by forecasters and decision makers.

Use of Remote Sensing Data to Enhance NWS Storm Damage Toolkit

NASA Astrophysics Data System (ADS)

Jedlovec, G.; Molthan, A.; White, K.; Burks, J.; Stellman, K.; Smith, M. R.

2012-12-01

In the wake of a natural disaster such as a tornado, the National Weather Service (NWS) is required to provide a very detailed and timely storm damage assessment to local, state and federal homeland security officials. The Post-Storm Data Acquisition (PSDA) procedure involves the acquisition and assembly of highly perishable data necessary for accurate post-event analysis and potential integration into a geographic information system (GIS) available to its end users and associated decision makers. Information gained from the process also enables the NWS to increase its knowledge of extreme events, learn how to better use existing equipment, improve NWS warning programs, and provide accurate storm intensity and damage information to the news media and academia. To help collect and manage all of this information, forecasters in NWS Southern Region are currently developing a Storm Damage Assessment Toolkit (SDAT), which incorporates GIS-capable phones and laptops into the PSDA process by tagging damage photography, location, and storm damage details with GPS coordinates for aggregation within the GIS database. However, this tool alone does not fully integrate radar and ground based storm damage reports nor does it help to identify undetected storm damage regions. In many cases, information on storm damage location (beginning and ending points, swath width, etc.) from ground surveys is incomplete or difficult to obtain. Geographic factors (terrain and limited roads in rural areas), manpower limitations, and other logistical constraints often prevent the gathering of a comprehensive picture of tornado or hail damage, and may allow damage regions to go undetected. Molthan et al. (2011) have shown that high resolution satellite data can provide additional valuable information on storm damage tracks to augment this database. This paper presents initial development to integrate satellite-derived damage track information into the SDAT for near real-time use by forecasters and decision makers.

A Proprietary Information Dissemination and Education System.

ERIC Educational Resources Information Center

Rollins, Timothy J.; Golden, Kerry

1994-01-01

In focus group interviews, 14 Pennsylvania Crop Management Association technicians identified their primary role as information providers and consultants, felt the need for better communication skills and training as nonformal adult educators, considered human resources the most valuable information sources, and believed farmers participated only…

Applying Customized Climate Advisory Information to Translate Extreme Rainfall Events into Farming Options in the Sudan-Sahel of West Africa

NASA Astrophysics Data System (ADS)

Salack, S.; Worou, N. O.; Sanfo, S.; Nikiema, M. P.; Boubacar, I.; Paturel, J. E.; Tondoh, E. J.

2017-12-01

In West Africa, the risk of food insecurity linked to the low productivity of small holder farming increases as a result of rainfall extremes. In its recent evolution, the rainy season in the Sudan-Sahel zone presents mixed patterns of extreme climatic events. In addition to intense rain events, the distribution of events is associated with pockets of intra-seasonal long dry spells. The negative consequences of these mixed patterns are obvious on the farm: soil water logging, erosion of arable land, dwartness and dessication of crops, and loss in production. The capacity of local farming communities to respond accordingly to rainfall extreme events is often constrained by lack of access to climate information and advisory on smart crop management practices that can help translate extreme rainfall events into farming options. The objective of this work is to expose the framework and the pre-liminary results of a scheme that customizes climate-advisory information package delivery to subsistence farmers in Bakel (Senegal), Ouahigouya & Dano (Burkina Faso) and Bolgatanga (Ghana) for sustainable family agriculture. The package is based on the provision of timely climate information (48-hours, dekadal & seasonal) embedded with smart crop management practices to explore and exploite the potential advantage of intense rainfall and extreme dry spells in millet, maize, sorghum and cowpea farming communities. It is sent via mobile phones and used on selected farms (i.e agro-climatic farm schools) on which some small on-farm infrastructure were built to alleviate negative impacts of weather. Results provide prominent insight on how co-production of weather/climate information, customized access and guidiance on its use can induce fast learning (capacity building of actors), motivation for adaptation, sustainability, potential changes in cropping system, yields and family income in the face of a rainfall extremes at local scales of Sudan-Sahel of West Africa. Keywords: Climate Information, Smart Practices, Farming Options, Agro-Climatic Farm Schools, Sudan-Sahel

HIV-AIDS Patients' Evaluation of Health Information on the Internet: The Digital Divide and Vulnerability to Fraudulent Claims

ERIC Educational Resources Information Center

Benotsch, Eric G.; Kalichman, Seth; Weinhardt, Lance S.

2004-01-01

Access to health information on the Internet has revolutionized how medical patients learn about their illnesses. Valuable information can be found online; however, many health Web sites contain inaccurate or misleading information. The authors surveyed 324 adults with HIV concerning their Internet use for obtaining health information. Health…

Assessing the features of extreme smog in China and the differentiated treatment strategy

NASA Astrophysics Data System (ADS)

Deng, Lu; Zhang, Zhengjun

2018-01-01

Extreme smog can have potentially harmful effects on human health, the economy and daily life. However, the average (mean) values do not provide strategically useful information on the hazard analysis and control of extreme smog. This article investigates China's smog extremes by applying extreme value analysis to hourly PM2.5 data from 2014 to 2016 obtained from monitoring stations across China. By fitting a generalized extreme value (GEV) distribution to exceedances over a station-specific extreme smog level at each monitoring location, all study stations are grouped into eight different categories based on the estimated mean and shape parameter values of fitted GEV distributions. The extreme features characterized by the mean of the fitted extreme value distribution, the maximum frequency and the tail index of extreme smog at each location are analysed. These features can provide useful information for central/local government to conduct differentiated treatments in cities within different categories and conduct similar prevention goals and control strategies among those cities belonging to the same category in a range of areas. Furthermore, hazardous hours, breaking probability and the 1-year return level of each station are demonstrated by category, based on which the future control and reduction targets of extreme smog are proposed for the cities of Beijing, Tianjin and Hebei as an example.

Development of a prototype geotechnical report.

DOT National Transportation Integrated Search

2014-12-01

Archive geotechnical reports in the department contain valuable information such as site maps, : photographs, borehole data, laboratory and field test data, and design analyses. A proper use of the : information may bring significant cost saving for ...

The use of Mohs micrographic surgery (MMS) for melanoma in situ (MIS) of the trunk and proximal extremities.

PubMed

Stigall, Landon E; Brodland, David G; Zitelli, John A

2016-11-01

Evaluation of the entire surgical margin results in high rates of complete excision, low local recurrence rates, and maximal tissue conservation. Although well recognized for melanoma of the head and neck, few studies have focused exclusively on the trunk and proximal extremities. We sought to evaluate the efficacy of Mohs micrographic surgery for melanoma in situ (MIS) of the trunk and proximal extremities, and determine adequate excision margins for MIS when total margin evaluation is not used. Long-term outcomes in 882 cases of MIS treated with Mohs micrographic surgery were analyzed and compared with historical controls. Rates of complete excision were determined for increasing surgical margin intervals. One local recurrence occurred in our cohort (0.1%). Only 83% of MIS were excised with a 6-mm margin. Margins of 9 mm were needed to excise 97% of MIS, statistically equivalent to thin melanomas. We used a nonrandomized, single-institution, retrospective design. Mohs micrographic surgery may cure the 17% of MIS that exceed traditional excision margins of 5 mm and is a valuable option for these patients. Surgical margins of at least 0.9 cm should be considered for MIS of the trunk and extremities when total margin evaluation is not used. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Science project

NASA Image and Video Library

2012-08-23

Once tethered in place in Gulf Coast waters, a DRIFTER sensor device is able to transmit valuable information about water temperature and conductivity. The Applied Science and Technology Project Office at Stennis Space Center designed the DRIFTER as an inexpensive device that can be used for science projects in local schools. Two of the devices, deployed in coastal waters, survived Hurricane Isaac, continuing to transmit valuable data regarding the storm.

Countering Internet Extremism

DTIC Science & Technology

2009-01-01

early stages of the conflict, and secure an information warfare victory. Extremists’ use of the Internet has developed rapidly since the Chechen...activities Countering Internet Extremism By Mr. Timothy L. Thomas Editorial Abstract: The author examines the modern informational environment, and...spite of all of these resources—plus all of the money the west has thrown into information (read Internet ) security—an individual known as Irhabi

The International Space Station: A Low-Earth Orbit (LEO) Test Bed for Advancements in Space and Environmental Medicine

NASA Technical Reports Server (NTRS)

Ruttley, Tara M.; Robinson, Julie A.

2010-01-01

Ground-based space analog projects such as the NASA Extreme Environment Mission Operations (NEEMO) can be valuable test beds for evaluation of experimental design and hardware feasibility before actually being implemented on orbit. The International Space Station (ISS) is an closed-system laboratory that orbits 240 miles above the Earth, and is the ultimate extreme environment. Its inhabitants spend hours performing research that spans from fluid physics to human physiology, yielding results that have implications for Earth-based improvements in medicine and health, as well as those that will help facilitate the mitigation of risks to the human body associated with exploration-class space missions. ISS health and medical experiments focus on pre-flight and in-flight prevention, in-flight treatment, and postflight recovery of health problems associated with space flight. Such experiments include those on enhanced medical monitoring, bone and muscle loss prevention, cardiovascular health, immunology, radiation and behavior. Lessons learned from ISS experiments may not only be applicable to other extreme environments that face similar capability limitations, but also serve to enhance standards of care for everyday use on Earth.

Recent Weather Extremes and Impacts on Agricultural Production and Vector-Borne Disease Outbreak Patterns

PubMed Central

Anyamba, Assaf; Small, Jennifer L.; Britch, Seth C.; Tucker, Compton J.; Pak, Edwin W.; Reynolds, Curt A.; Crutchfield, James; Linthicum, Kenneth J.

2014-01-01

We document significant worldwide weather anomalies that affected agriculture and vector-borne disease outbreaks during the 2010–2012 period. We utilized 2000–2012 vegetation index and land surface temperature data from NASA's satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) to map the magnitude and extent of these anomalies for diverse regions including the continental United States, Russia, East Africa, Southern Africa, and Australia. We demonstrate that shifts in temperature and/or precipitation have significant impacts on vegetation patterns with attendant consequences for agriculture and public health. Weather extremes resulted in excessive rainfall and flooding as well as severe drought, which caused ∼10 to 80% variation in major agricultural commodity production (including wheat, corn, cotton, sorghum) and created exceptional conditions for extensive mosquito-borne disease outbreaks of dengue, Rift Valley fever, Murray Valley encephalitis, and West Nile virus disease. Analysis of MODIS data provided a standardized method for quantifying the extreme weather anomalies observed during this period. Assessments of land surface conditions from satellite-based systems such as MODIS can be a valuable tool in national, regional, and global weather impact determinations. PMID:24658301

Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations.

PubMed

Kim, Dae-Hyeong; Song, Jizhou; Choi, Won Mook; Kim, Hoon-Sik; Kim, Rak-Hwan; Liu, Zhuangjian; Huang, Yonggang Y; Hwang, Keh-Chih; Zhang, Yong-wei; Rogers, John A

2008-12-02

Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable new biomedical devices and other applications whose requirements are impossible to satisfy with conventional wafer-based technologies or even with those that offer simple bendability. This article introduces materials and mechanical design strategies for classes of electronic circuits that offer extremely high stretchability, enabling them to accommodate even demanding configurations such as corkscrew twists with tight pitch (e.g., 90 degrees in approximately 1 cm) and linear stretching to "rubber-band" levels of strain (e.g., up to approximately 140%). The use of single crystalline silicon nanomaterials for the semiconductor provides performance in stretchable complementary metal-oxide-semiconductor (CMOS) integrated circuits approaching that of conventional devices with comparable feature sizes formed on silicon wafers. Comprehensive theoretical studies of the mechanics reveal the way in which the structural designs enable these extreme mechanical properties without fracturing the intrinsically brittle active materials or even inducing significant changes in their electrical properties. The results, as demonstrated through electrical measurements of arrays of transistors, CMOS inverters, ring oscillators, and differential amplifiers, suggest a valuable route to high-performance stretchable electronics.

Online Health Information Seeking in Hand and Upper Extremity Surgery.

PubMed

Özkan, Sezai; Mellema, Jos J; Nazzal, Adam; Lee, Sang-Gil; Ring, David

2016-12-01

Information gathering is a key component of shared decision making and has a measurable effect on treatment decisions. Access to health information might improve quality of care in hand surgery. Our purpose was to identify socio-demographic, condition-related, and psychosocial factors associated with online information-seeking behavior in patients with hand and upper-extremity conditions. From June 2015 to February 2016, we enrolled 134 patients with an upper-extremity condition who presented to an outpatient hand surgery office at an urban level I trauma center in this cross-sectional study. Participants provided socio-demographic information and completed online questionnaires assessing their online information-seeking behavior, pain intensity, symptoms of depression, and pain interference, and an upper extremity-specific, patient-reported outcome measure. A total of 57 patients (43%) sought information regarding their condition online before their visit. Compared with patients with no online information-seeking behavior, patients who sought information online were more educated. Psychosocial and condition-related factors were not associated with online information seeking. In multivariable analysis, education in years and involvement of the dominant upper limb were independently associated with online information-seeking behavior. Education in years and involvement of the dominant upper limb were independently associated with online information-seeking behavior but psychosocial and condition-related factors were not. As health information seeking is becoming an integral part of the modern day clinical experience, efforts to make online information more appealing and useful to people of all education levels are merited. Copyright © 2016 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Seasonal and Non-Seasonal Generalized Pareto Distribution to Estimate Extreme Significant Wave Height in The Banda Sea

NASA Astrophysics Data System (ADS)

Nursamsiah; Nugroho Sugianto, Denny; Suprijanto, Jusup; Munasik; Yulianto, Bambang

2018-02-01

The information of extreme wave height return level was required for maritime planning and management. The recommendation methods in analyzing extreme wave were better distributed by Generalized Pareto Distribution (GPD). Seasonal variation was often considered in the extreme wave model. This research aims to identify the best model of GPD by considering a seasonal variation of the extreme wave. By using percentile 95 % as the threshold of extreme significant wave height, the seasonal GPD and non-seasonal GPD fitted. The Kolmogorov-Smirnov test was applied to identify the goodness of fit of the GPD model. The return value from seasonal and non-seasonal GPD was compared with the definition of return value as criteria. The Kolmogorov-Smirnov test result shows that GPD fits data very well both seasonal and non-seasonal model. The seasonal return value gives better information about the wave height characteristics.

The biological roots of political extremism.

PubMed

Keene, Justin Robert; Shoenberger, Heather; Berke, Collin K; Bolls, Paul D

2017-01-01

Recent research has revealed the complex origins of political identification and the possible effects of this identification on social and political behavior. This article reports the results of a structural equation analysis of national survey data that attempts to replicate the finding that an individual's negativity bias predicts conservative ideology. The analysis employs the Motivational Activation Measure (MAM) as an index of an individual's positivity offset and negativity bias. In addition, information-seeking behavior is assessed in relation to traditional and interactive media sources of political information. Results show that although MAM does not consistently predict political identification, it can be used to predict extremeness of political views. Specifically, high negativity bias was associated with extreme conservatism, whereas low negativity bias was associated with extreme liberalism. In addition, political identification was found to moderate the relationship between motivational traits and information-seeking behavior.

Memorandum for the Heads of Executive Departments and Agencies: Open Data Policy--Managing Information as an Asset

DOT National Transportation Integrated Search

2013-05-09

Information is a valuable national resource and a strategic asset to the Federal Government, its partners, and the public. In order to ensure that the Federal Government is taking full advantage of its information resources, executive departments and...

Student Technology Use for Powerful Learning

ERIC Educational Resources Information Center

Heidenrich, Carol

2013-01-01

Technology has evolved as a valuable information and communication tool. In our knowledge and information society, students with information and communication technology (ICT) competence will be prepared for success. Teacher pedagogy and student learning have to change to fully integrate technology into the curriculum. Students may not have…

Climate Change Extreme Events: Meeting the Information Needs of Water Resource Managers

NASA Astrophysics Data System (ADS)

Quay, R.; Garfin, G. M.; Dominguez, F.; Hirschboeck, K. K.; Woodhouse, C. A.; Guido, Z.; White, D. D.

2013-12-01

Information about climate has long been used by water managers to develop short term and long term plans and strategies for regional and local water resources. Inherent within longer term forecasts is an element of uncertainty, which is particularly evident in Global Climate model results for precipitation. For example in the southwest estimates in the flow of the Colorado River based on GCM results indicate changes from 120% or current flow to 60%. Many water resource managers are now using global climate model down scaled estimates results as indications of potential climate change as part of that planning. They are addressing the uncertainty within these estimates by using an anticipatory planning approach looking at a range of possible futures. One aspect of climate that is important for such planning are estimates of future extreme storm (short term) and drought (long term) events. However, the climate science of future possible changes in extreme events is less mature than general climate change science. At a recent workshop among climate scientists and water managers in the southwest, it was concluded the science of climate change extreme events is at least a decade away from being robust enough to be useful for water managers in their water resource management activities. However, it was proposed that there are existing estimates and records of past flooding and drought events that could be combined with general climate change science to create possible future events. These derived events could be of sufficient detail to be used by water resource managers until such time that the science of extreme events is able to provide more detailed estimates. Based on the results of this workshop and other work being done by the Decision Center for a Desert City at Arizona State University and the Climate Assessment for the Southwest center at University of Arizona., this article will 1) review what are the extreme event data needs of Water Resource Managers in the southwest, 2) review of the current state of extreme event climate science, 3) review what information is available about past extreme events in the southwest, 4) report the results of the 2012 workshop on climate change and extreme events, and 5) propose a method for combining this past information with current climate science information to produce estimates of possible future extreme events in sufficient detail to be useful to water resource managers.

Detection and characterizacion of Colombian wetlands using Alos Palsar and MODIS imagery

NASA Astrophysics Data System (ADS)

Estupinan-Suarez, L. M.; Florez-Ayala, C.; Quinones, M. J.; Pacheco, A. M.; Santos, A. C.

2015-04-01

Wetlands regulate the flow of water and play a key role in risk management of extreme flooding and drought. In Colombia, wetland conservation has been a priority for the government. However, there is an information gap neither an inventory nor a national baseline map exists. In this paper, we present a method that combines a wetlands thematic map with remote sensing derived data, and hydrometeorological stations data in order to characterize the Colombian wetlands. Following the adopted definition of wetlands, available spatial data on land forms, soils and vegetation was integrated in order to characterize spatially the occurrence of wetlands. This data was then complemented with remote sensing derived data from active and passive sensors. A flood frequency map derived from dense time series analysis of the ALOS PALSAR FBD /FBS data (2007-2010) at 50m resolution was used to analyse the recurrence of flooding. In this map, flooding under the canopy and open water classes could be mapped due to the capabilities of the L-band radar. In addition, MODIS NDVI profiles (2007-2012) were used to characterize temporally water mirrors and vegetation, founding different patterns at basin levels. Moreover, the Colombian main basins were analysed and typified based on hydroperiods, highlighting different hydrological regimes within each basin. The combination of thematic maps, SAR data, optical imagery and hydrological data provided information on the spatial and temporal dynamics of wetlands at regional scales. Our results provide the first validated baseline wetland map for Colombia, this way providing valuable information for ecosystem management.

Assessing Flood Risk Under Sea Level Rise and Extreme Sea Levels Scenarios: Application to the Ebro Delta (Spain)

NASA Astrophysics Data System (ADS)

Sayol, J. M.; Marcos, M.

2018-02-01

This study presents a novel methodology to estimate the impact of local sea level rise and extreme surges and waves in coastal areas under climate change scenarios. The methodology is applied to the Ebro Delta, a valuable and vulnerable low-lying wetland located in the northwestern Mediterranean Sea. Projections of local sea level accounting for all contributions to mean sea level changes, including thermal expansion, dynamic changes, fresh water addition and glacial isostatic adjustment, have been obtained from regionalized sea level projections during the 21st century. Particular attention has been paid to the uncertainties, which have been derived from the spread of the multi-model ensemble combined with seasonal/inter-annual sea level variability from local tide gauge observations. Besides vertical land movements have also been integrated to estimate local relative sea level rise. On the other hand, regional projections over the Mediterranean basin of storm surges and wind-waves have been used to evaluate changes in extreme events. The compound effects of surges and extreme waves have been quantified using their joint probability distributions. Finally, offshore sea level projections from extreme events superimposed to mean sea level have been propagated onto a high resolution digital elevation model of the study region in order to construct flood hazards maps for mid and end of the 21st century and under two different climate change scenarios. The effect of each contribution has been evaluated in terms of percentage of the area exposed to coastal hazards, which will help to design more efficient protection and adaptation measures.

Phantom radiculitis effectively treated by fluoroscopically guided transforaminal epidural steroid injections.

PubMed

DeGregoris, Gerard; Diwan, Sudhir

2010-01-01

Lower back and extremity pain in the amputee patient can be challenging to classify and treat. Radicular compression in a patient with lower limb amputation may present as or be superimposed upon phantom limb pain, creating diagnostic difficulties. Both patients and physicians classically find it difficult to discern phantom sensation from phantom limb pain and stump pain; radicular compression is often not considered. Many studies have shown back pain to be a significant cause of pain in lower limb amputees, but sciatica has been rarely reported in amputees. We present a case of L4/5 radiculitis in an above-knee amputee presenting as phantom radiculitis. Our patient is a 67 year old gentleman with new onset 10/10 pain in a phantom extremity superimposed upon a 40 year history of previously stable phantom limb pain. MRI showed a central disc herniation at L4/5 with compression of the traversing left L4 nerve root. Two fluoroscopically guided left transforaminal epidural steroid injections at the level of the L4 and L5 spinal nerve roots totally alleviated his new onset pain. At one year post injection, his phantom radiculitis pain was completely gone, though his underlying phantom limb pain remained. Lumbar radiculitis in lower extremity amputee patients may be difficult to differentiate from baseline phantom limb pain. When conservative techniques fail, fluoroscopically guided spinal nerve injection may be valuable in determining the etiology of lower extremity pain. Our experience supports the notion that epidural steroid injections can effectively treat phantom lumbar radiculitis in lower extremity amputees.

Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments

PubMed Central

Yang, Ji; Li, Wen-Rong; Lv, Feng-Hua; He, San-Gang; Tian, Shi-Lin; Peng, Wei-Feng; Sun, Ya-Wei; Zhao, Yong-Xin; Tu, Xiao-Long; Zhang, Min; Xie, Xing-Long; Wang, Yu-Tao; Li, Jin-Quan; Liu, Yong-Gang; Shen, Zhi-Qiang; Wang, Feng; Liu, Guang-Jian; Lu, Hong-Feng; Kantanen, Juha; Han, Jian-Lin; Li, Meng-Hua; Liu, Ming-Jun

2016-01-01

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8–9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. PMID:27401233

Phenotypic landscape of non-conventional yeast species for different stress tolerance traits desirable in bioethanol fermentation.

PubMed

Mukherjee, Vaskar; Radecka, Dorota; Aerts, Guido; Verstrepen, Kevin J; Lievens, Bart; Thevelein, Johan M

2017-01-01

Non-conventional yeasts present a huge, yet barely exploited, resource of yeast biodiversity for industrial applications. This presents a great opportunity to explore alternative ethanol-fermenting yeasts that are more adapted to some of the stress factors present in the harsh environmental conditions in second-generation (2G) bioethanol fermentation. Extremely tolerant yeast species are interesting candidates to investigate the underlying tolerance mechanisms and to identify genes that when transferred to existing industrial strains could help to design more stress-tolerant cell factories. For this purpose, we performed a high-throughput phenotypic evaluation of a large collection of non-conventional yeast species to identify the tolerance limits of the different yeast species for desirable stress tolerance traits in 2G bioethanol production. Next, 12 multi-tolerant strains were selected and used in fermentations under different stressful conditions. Five strains out of which, showing desirable fermentation characteristics, were then evaluated in small-scale, semi-anaerobic fermentations with lignocellulose hydrolysates. Our results revealed the phenotypic landscape of many non-conventional yeast species which have not been previously characterized for tolerance to stress conditions relevant for bioethanol production. This has identified for each stress condition evaluated several extremely tolerant non- Saccharomyces yeasts. It also revealed multi-tolerance in several yeast species, which makes those species good candidates to investigate the molecular basis of a robust general stress tolerance. The results showed that some non-conventional yeast species have similar or even better fermentation efficiency compared to S. cerevisiae in the presence of certain stressful conditions. Prior to this study, our knowledge on extreme stress-tolerant phenotypes in non-conventional yeasts was limited to only few species. Our work has now revealed in a systematic way the potential of non- Saccharomyces species to emerge either as alternative host species or as a source of valuable genetic information for construction of more robust industrial S. serevisiae bioethanol production yeasts. Striking examples include yeast species like Pichia kudriavzevii and Wickerhamomyces anomalus that show very high tolerance to diverse stress factors. This large-scale phenotypic analysis has yielded a detailed database useful as a resource for future studies to understand and benefit from the molecular mechanisms underlying the extreme phenotypes of non-conventional yeast species.

A Study of Personal Information Management Strategies for Online Faculty

ERIC Educational Resources Information Center

Kearns, Lorna R.; Frey, Barbara A.; Tomer, Christinger; Alman, Susan

2014-01-01

The literature suggests that personal information management is a serious challenge for many computer users. Online faculty are especially challenged because of the large number of electronic files necessitated by teaching online. Those who have experience in this environment may offer valuable insights regarding information management challenges…

Mathematics Framework for the 2013 National Assessment of Educational Progress

ERIC Educational Resources Information Center

National Assessment Governing Board, 2012

2012-01-01

Since 1973, the National Assessment of Educational Progress (NAEP) has gathered information about student achievement in mathematics. Results of these periodic assessments, produced in print and web-based formats, provide valuable information to a wide variety of audiences. They inform citizens about the nature of students' comprehension of the…

48 CFR 915.207-70 - Handling proposals and information during evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... information (data) before decision as to the award of a contract, or the transfer of valuable and sensitive information between competing offerors during the competitive phase of the acquisition process, would seriously disrupt the Government's decision-making process and undermine the integrity of the competitive...

77 FR 50711 - Notice of Proposed Information Collection for Public Comment: Pre-Purchase Homeownership...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... Information Collection for Public Comment: Pre-Purchase Homeownership Counseling Demonstration and Impact... homeownership counseling. The evaluation will produce valuable information about the impact of pre- purchase homeownership counseling on a range of outcomes for low- to moderate-income, first-time home buyers. This is the...

Moving in extreme environments: what's extreme and who decides?

PubMed

Cotter, James David; Tipton, Michael J

2014-01-01

Humans work, rest and play in immensely varied extreme environments. The term 'extreme' typically refers to insufficiency or excess of one or more stressors, such as thermal energy or gravity. Individuals' behavioural and physiological capacity to endure and enjoy such environments varies immensely. Adverse effects of acute exposure to these environments are readily identifiable (e.g. heat stroke or bone fracture), whereas adverse effects of chronic exposure (e.g. stress fractures or osteoporosis) may be as important but much less discernable. Modern societies have increasingly sought to protect people from such stressors and, in that way, minimise their adverse effects. Regulations are thus established, and advice is provided on what is 'acceptable' exposure. Examples include work/rest cycles in the heat, hydration regimes, rates of ascent to and duration of stay at altitude and diving depth. While usually valuable and well intentioned, it is important to realise the breadth and importance of limitations associated with such guidelines. Regulations and advisories leave less room for self-determination, learning and perhaps adaptation. Regulations based on stress (e.g. work/rest cycles relative to WBGT) are more practical but less direct than those based on strain (e.g. core temperature), but even the latter can be substantively limited (e.g. by lack of criterion validation and allowance for behavioural regulation in the research on which they are based). Extreme Physiology & Medicine is publishing a series of reviews aimed at critically examining the issues involved with self- versus regulation-controlled human movement acutely and chronically in extreme environments. These papers, arising from a research symposium in 2013, are about the impact of people engaging in such environments and the effect of rules and guidelines on their safety, enjoyment, autonomy and productivity. The reviews will cover occupational heat stress, sporting heat stress, hydration, diving, extreme loading, chronic unloading and high altitude. Ramifications include factors such as health and safety, productivity, enjoyment and autonomy, acute and chronic protection and optimising adaptation.

Undergraduate Students' Use of Online Information in World Geography: Source Types and Selection Criteria

ERIC Educational Resources Information Center

Hong, Jung Eun; Jo, Injeong

2017-01-01

Offering up-to-date information and diverse perspectives on issues, online information can be a valuable resource that supplements traditional course materials like textbooks. In this paper, the source types that students' use for a course assignment and the criteria they apply to determine usefulness of the online information are examined.…

A trough for improved SFG spectroscopy of lipid monolayers.

PubMed

Franz, Johannes; van Zadel, Marc-Jan; Weidner, Tobias

2017-05-01

Lipid monolayers are indispensable model systems for biological membranes. The main advantage over bilayer model systems is that the surface pressure within the layer can be directly and reliably controlled. The sensitive interplay between surface pressure and temperature determines the molecular order within a model membrane and consequently determines the membrane phase behavior. The lipid phase is of crucial importance for a range of membrane functions such as protein interactions and membrane permeability. A very reliable method to probe the structure of lipid monolayers is sum frequency generation (SFG) vibrational spectroscopy. Not only is SFG extremely surface sensitive but it can also directly access critical parameters such as lipid order and orientation, and it can provide valuable information about protein interactions along with interfacial hydration. However, recent studies have shown that temperature gradients caused by high power laser beams perturb the lipid layers and potentially obscure the spectroscopic results. Here we demonstrate how the local heating problem can be effectively reduced by spatially distributing the laser pulses on the sample surface using a translating Langmuir trough for SFG experiments at lipid monolayers. The efficiency of the trough is illustrated by the detection of enhanced molecular order due to reduced heat load.

A trough for improved SFG spectroscopy of lipid monolayers

NASA Astrophysics Data System (ADS)

Franz, Johannes; van Zadel, Marc-Jan; Weidner, Tobias

2017-05-01

Lipid monolayers are indispensable model systems for biological membranes. The main advantage over bilayer model systems is that the surface pressure within the layer can be directly and reliably controlled. The sensitive interplay between surface pressure and temperature determines the molecular order within a model membrane and consequently determines the membrane phase behavior. The lipid phase is of crucial importance for a range of membrane functions such as protein interactions and membrane permeability. A very reliable method to probe the structure of lipid monolayers is sum frequency generation (SFG) vibrational spectroscopy. Not only is SFG extremely surface sensitive but it can also directly access critical parameters such as lipid order and orientation, and it can provide valuable information about protein interactions along with interfacial hydration. However, recent studies have shown that temperature gradients caused by high power laser beams perturb the lipid layers and potentially obscure the spectroscopic results. Here we demonstrate how the local heating problem can be effectively reduced by spatially distributing the laser pulses on the sample surface using a translating Langmuir trough for SFG experiments at lipid monolayers. The efficiency of the trough is illustrated by the detection of enhanced molecular order due to reduced heat load.

Research: increasing value, reducing waste 2

PubMed Central

Ioannidis, John P A; Greenland, Sander; Hlatky, Mark A; Khoury, Muin J; Macleod, Malcolm R; Moher, David; Schulz, Kenneth F; Tibshirani, Robert

2015-01-01

Correctable weaknesses in the design, conduct, and analysis of biomedical and public health research studies can produce misleading results and waste valuable resources. Small effects can be difficult to distinguish from bias introduced by study design and analyses. An absence of detailed written protocols and poor documentation of research is common. Information obtained might not be useful or important, and statistical precision or power is often too low or used in a misleading way. Insufficient consideration might be given to both previous and continuing studies. Arbitrary choice of analyses and an overemphasis on random extremes might affect the reported findings. Several problems relate to the research workforce, including failure to involve experienced statisticians and methodologists, failure to train clinical researchers and laboratory scientists in research methods and design, and the involvement of stakeholders with conflicts of interest. Inadequate emphasis is placed on recording of research decisions and on reproducibility of research. Finally, reward systems incentivise quantity more than quality, and novelty more than reliability. We propose potential solutions for these problems, including improvements in protocols and documentation, consideration of evidence from studies in progress, standardisation of research efforts, optimisation and training of an experienced and non-conflicted scientific workforce, and reconsideration of scientific reward systems. PMID:24411645

Utility of Thermal Infrared Satellite Data For Urban Landscapes

NASA Astrophysics Data System (ADS)

Xian, G.; Crane, M.; Granneman, B.

2006-12-01

Urban landscapes are comprised of a variety of surfaces that are characterized by contrasting radiative, thermal, aerodynamic, and moisture properties. These different surfaces possess diverse physical and thermal attributes that directly influence surface energy balance and our ability to determine surface characteristics in urban areas. Reflectance properties obtained from satellite imagery have proven useful for mapping urban land use and land cover change, as well as ecosystem health. Landsat reflectance bands are commonly used in regression tree models to generate linear equations that correspond to distinct land surface materials. However, urban land cover is generally a heterogeneous mix of bare soil, vegetation, rock, and anthropogenic impervious surfaces. Surface temperature obtained from satellite thermal infrared bands provides valuable information about surface biophysical properties and radiant thermal characteristics of land cover elements, especially for urban environments. This study demonstrates the improved characterization of land cover conditions for Seattle, Washington, and Las Vegas, Nevada, that were achieved by using both the reflectance and thermal bands of Landsat Enhanced Thematic Mapper Plus (ETM+) data. Including the thermal band in the image analysis increased the accuracy of discriminating cover types in heterogeneous landscapes with extreme contrasts, especially for mixed pixels at the urban interface.

DNA barcoding of freshwater ichthyoplankton in the Neotropics as a tool for ecological monitoring.

PubMed

Frantine-Silva, W; Sofia, S H; Orsi, M L; Almeida, F S

2015-09-01

Quantifying and classifying ichthyoplankton is one of the most effective ways of monitoring the recruitment process in fishes. However, correctly identifying the fish based on morphological characters is extremely difficult, especially in the early stages of development. We examined ichthyoplankton from tributaries and reservoirs along the middle stretch of the Paranapanema River, one of the areas most impacted by hydroelectric projects in the Neotropics. Matching DNA sequences of the COI gene (628-648 bp) allowed us to identify 99.25% of 536 samples of eggs (293) and larvae (243) subjected to BOLD-IDS similarity analysis with a species-level threshold of 1.3%. The results revealed 37 species in 27 genera, 15 families and four orders, some 23.8% of documented fish species in the Paranapanema River. Molecular identification meant that we could include data from egg samples that accounted for about 30% of the species richness observed. The results in this study confirm the efficacy of DNA barcoding in identifying Neotropical ichthyoplankton and show how the data produced provide valuable information for preparing plans for conserving and managing inland waters. © 2015 John Wiley & Sons Ltd.

Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

NASA Astrophysics Data System (ADS)

Patil, Ajeetkumar; Unnikrishnan V., K.; Ongole, Ravikiran; Pai, Keerthilatha M.; Kartha, V. B.; Chidangil, Santhosh

2015-07-01

Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where "tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions" and "current techniques detect malignant change too late" [3], and "biopsies are not representative of the whole premalignant lesion". [4

The Vital Infrared to X-ray Link in the Sgr A* Accretion Flow

NASA Astrophysics Data System (ADS)

Fazio, Giovanni; Ashby, Matthew; Baganoff, Frederick; Becklin, Eric; Boyce, Hope; Carey, Sean; Gammie, Charles; Ghez, Andrea; Glaccum, William; Gurwell, Mark; Haggard, Daryl; Herrero-Illana, Ruben; Hora, Joseph; Ingalls, James; Lowrance, Patrick; Markoff, Sera; Marrone, Daniel; Morris, Mark; Narayan, Ramesh; Neilsen, Joseph; Ponti, Gabriele; Smith, Howard; Willner, Steven; Witzel, Gunther

2018-05-01

Black hole accretion drives extreme astrophysical phenomena in the universe. Sgr A*, the radiating counterpart of the nearest supermassive black hole, is highly variable, but sparse data and short observations have left its emission physics in question. Despite enormous advances in accretion models, physical description of the interacting radiation mechanisms is incomplete. The X-ray emission mechanism in particular remains unknown. Because the necessary information is contained in the time-dependent relation between X-ray and infrared emission, we have begun monitoring Sgr A* simultaneously with Chandra in X-rays and with Spitzer in the infrared. Defining the X-ray to infrared flux density ratio will allow the entire energy distribution to be understood. We therefore request two new 24-hour epochs of Spitzer monitoring at 4.5 microns simultaneous with Chandra time already approved. This will increase the exposure time for X-ray flares where the NIR state is known, moving us out of the realm of small-number statistics and enabling diagnostics of the true X-ray/IR ratio. Under current NASA plans, this will be the last chance for these valuable Spitzer+Chandra observations.

Ethical guidance in the era of managed care: an analysis of the American College of Healthcare Executives' Code of Ethics.

PubMed

Higgins, W

2000-01-01

Market competition and the rise of managed care are transforming the healthcare system from a physician-dominated cottage industry into a manager-dominated corporate enterprise. The managed care revolution is also undermining the safe-guards offered by medical ethics and raising serious public concerns. These trends highlight the growing importance of ethical standards for managers. The most comprehensive ethical guidance for health service managers is contained in the American College of Healthcare Executives' (ACHE) Code of Ethics. An analysis of the ACHE Code suggests that it does not adequately address several ethical concerns associated with managed care. The ACHE may wish to develop a supplemental statement regarding ethical issues in managed care. A supplemental statement that provides more specific guidance in the areas of financial incentives to reduce utilization, social mission, consumer/patient information, and the health service manager's responsibility to patients could be extremely valuable in today's complex and rapidly changing environment. More specific ethical guidelines would not ensure individual or organizational compliance. However, they would provide professional standards that could guide decision making and help managers evaluate performance in managed care settings.

Thermal Transport in Graphene Oxide – From Ballistic Extreme to Amorphous Limit

PubMed Central

Mu, Xin; Wu, Xufei; Zhang, Teng; Go, David B.; Luo, Tengfei

2014-01-01

Graphene oxide is being used in energy, optical, electronic and sensor devices due to its unique properties. However, unlike its counterpart – graphene – the thermal transport properties of graphene oxide remain unknown. In this work, we use large-scale molecular dynamics simulations with reactive potentials to systematically study the role of oxygen adatoms on the thermal transport in graphene oxide. For pristine graphene, highly ballistic thermal transport is observed. As the oxygen coverage increases, the thermal conductivity is significantly reduced. An oxygen coverage of 5% can reduce the graphene thermal conductivity by ~90% and a coverage of 20% lower it to ~8.8 W/mK. This value is even lower than the calculated amorphous limit (~11.6 W/mK for graphene), which is usually regarded as the minimal possible thermal conductivity of a solid. Analyses show that the large reduction in thermal conductivity is due to the significantly enhanced phonon scattering induced by the oxygen defects which introduce dramatic structural deformations. These results provide important insight to the thermal transport physics in graphene oxide and offer valuable information for the design of graphene oxide-based materials and devices. PMID:24468660

Transcriptome sequencing for identification of diapause-associated genes in fall webworm, Hyphantria cunea Drury.

PubMed

Deng, Yu; Li, Fei; Rieske, Lynne K; Sun, Li-Li; Sun, Shou-Hui

2018-08-20

Fall webworm, Hyphantria cunea Drury (Lepidoptera: Arctiidae) is extremely adaptable and highly invasive in China as a defoliator of ornamental and forest trees. Both voltinism and diapause strategies of fall webworm in China are variable, and this variability contributes to it invasiveness. Little is known about molecular regulation of diapause in fall webworm. To gain insight into possible mechanisms of diapause induction, high-throughput RNA-seq data were generated from non-diapause pupae (NDP) and diapause pupae (DP). A total of 58,151 unigenes were assembled and researched against nine public databases. In total, 29,013 up-regulated and 3451 down-regulated unigenes were differentially expressed by DP when compared with those of NDP. Genes encoding proteins such as UDP-glycosyl transferase (UGT), cytochrome P450 and Hsp70 were predicted to be involved in diapause. Moreover, GO function and KEGG pathway enrichments were performed on all differentially expressed genes (DEGs) and showed that cell cycle and insulin signaling pathways may be related to the diapause of the fall webworm. This study provides valuable information about the fall webworm transcriptome for future gene function research, especially as it relates to diapause. Copyright © 2018 Elsevier B.V. All rights reserved.

Foster carer experience in Spain: Analysis of the vulnerabilities of a permanent model.

PubMed

López López, Mónica; Del Valle, Jorge F

2016-05-01

The voice of foster families is a valuable tool in the development and improvement of foster family services. Regularly evaluating the satisfaction of foster carers can facilitate the early identification of a range of problems that might pose a risk to the placement. This article reports the experience of 200 Spanish foster families (kinship and non-kinship) with foster services in relation to motivation for becoming foster carers, sources of stress and reward, satisfaction with the services and needs. Semi-structured interviews were performed. The aims of the research are principally of a descriptive character, so each group of variables was examined using frequency analysis. The foster carers interviewed demonstrated a high degree of satisfaction with the foster programs, although some areas seem more problematic, such as financial compensation, information provided about the fostered child, contact with the birth family and the sensitivity of professionals. This study reveals several differences with regard to international literature, that are related to particularities of the Spanish child care system. The results may be extremely useful for the implementation of policy changes which could contribute to raised levels of satisfaction for the foster carers, and increased effectiveness of the programs.

Statistical Analysis Aiming at Predicting Respiratory Tract Disease Hospital Admissions from Environmental Variables in the City of São Paulo

PubMed Central

de Sousa Zanotti Stagliorio Coêlho, Micheline; Luiz Teixeira Gonçalves, Fabio; do Rosário Dias de Oliveira Latorre, Maria

2010-01-01

This study is aimed at creating a stochastic model, named Brazilian Climate and Health Model (BCHM), through Poisson regression, in order to predict the occurrence of hospital respiratory admissions (for children under thirteen years of age) as a function of air pollutants, meteorological variables, and thermal comfort indices (effective temperatures, ET). The data used in this study were obtained from the city of São Paulo, Brazil, between 1997 and 2000. The respiratory tract diseases were divided into three categories: URI (Upper Respiratory tract diseases), LRI (Lower Respiratory tract diseases), and IP (Influenza and Pneumonia). The overall results of URI, LRI, and IP show clear correlation with SO2 and CO, PM10 and O3, and PM10, respectively, and the ETw4 (Effective Temperature) for all the three disease groups. It is extremely important to warn the government of the most populated city in Brazil about the outcome of this study, providing it with valuable information in order to help it better manage its resources on behalf of the whole population of the city of Sao Paulo, especially those with low incomes. PMID:20706674

Exploratory investigations of hypervelocity intact capture spectroscopy

NASA Technical Reports Server (NTRS)

Tsou, P.; Griffiths, D. J.

1993-01-01

The ability to capture hypervelocity projectiles intact opens a new technique available for hypervelocity research. A determination of the reactions taking place between the projectile and the capture medium during the process of intact capture is extremely important to an understanding of the intact capture phenomenon, to improving the capture technique, and to developing a theory describing the phenomenon. The intact capture of hypervelocity projectiles by underdense media generates spectra, characteristic of the material species of projectile and capture medium involved. Initial exploratory results into real-time characterization of hypervelocity intact capture techniques by spectroscopy include ultra-violet and visible spectra obtained by use of reflecting gratings, transmitting gratings, and prisms, and recorded by photographic and electronic means. Spectrometry proved to be a valuable real-time diagnostic tool for hypervelocity intact capture events, offering understanding of the interactions of the projectile and the capture medium during the initial period and providing information not obtainable by other characterizations. Preliminary results and analyses of spectra produced by the intact capture of hypervelocity aluminum spheres in polyethylene (PE), polystyrene (PS), and polyurethane (PU) foams are presented. Included are tentative emission species identifications, as well as gray body temperatures produced in the intact capture process.

NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases

PubMed Central

Wang, Jianjian; Cao, Yuze; Zhang, Huixue; Wang, Tianfeng; Tian, Qinghua; Lu, Xiaoyu; Lu, Xiaoyan; Kong, Xiaotong; Liu, Zhaojun; Wang, Ning; Zhang, Shuai; Ma, Heping; Ning, Shangwei; Wang, Lihua

2017-01-01

The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD–ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD–ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs. PMID:27899613

Introducing Bayesian thinking to high-throughput screening for false-negative rate estimation.

PubMed

Wei, Xin; Gao, Lin; Zhang, Xiaolei; Qian, Hong; Rowan, Karen; Mark, David; Peng, Zhengwei; Huang, Kuo-Sen

2013-10-01

High-throughput screening (HTS) has been widely used to identify active compounds (hits) that bind to biological targets. Because of cost concerns, the comprehensive screening of millions of compounds is typically conducted without replication. Real hits that fail to exhibit measurable activity in the primary screen due to random experimental errors will be lost as false-negatives. Conceivably, the projected false-negative rate is a parameter that reflects screening quality. Furthermore, it can be used to guide the selection of optimal numbers of compounds for hit confirmation. Therefore, a method that predicts false-negative rates from the primary screening data is extremely valuable. In this article, we describe the implementation of a pilot screen on a representative fraction (1%) of the screening library in order to obtain information about assay variability as well as a preliminary hit activity distribution profile. Using this training data set, we then developed an algorithm based on Bayesian logic and Monte Carlo simulation to estimate the number of true active compounds and potential missed hits from the full library screen. We have applied this strategy to five screening projects. The results demonstrate that this method produces useful predictions on the numbers of false negatives.

Paleo-event data standards for dendrochronology

Treesearch

Elaine Kennedy Sutherland; P. Brewer; W. Gross

2017-01-01

Extreme environmental events, such as storm winds, landslides, insect infestations, and wildfire, cause loss of life, resources, and human infrastructure. Disaster riskreduction analysis can be improved with information about past frequency, intensity, and spatial patterns of extreme events. Tree-ring analyses can provide such information: tree rings reflect events as...

Informing Mechanistic Toxicology with Computational Molecular Models

EPA Science Inventory

Computational molecular models of chemicals interacting with biomolecular targets provides toxicologists a valuable, affordable, and sustainable source of in silico molecular level information that augments, enriches, and complements in vitro and in vivo effo...

[The informative value of the functional step test for the purpose of computed optical topography in the children presenting with the functional disorders of the musculoskeletal system].

PubMed

Trukhmanov, I M; Suslova, G A; Ponomarenko, G N

This paper is devoted to the characteristic of the informative value of the functional step test with the application of the heel cushions in the children for the purpose of differential diagnostics of anatomic and functional differences in the length of the lower extremities. A total of 85 schoolchildren with different length of the lower extremities have been examined. The comparative evaluation of the results of clinical and instrumental examinations was undertaken. The data obtained with the help of the functional step test give evidence of its very high sensitivity, specificity, and clinical significant as a tool for the examination of the children with different length of the low extremities. It is concluded that the test is one of the most informative predictors of the effectiveness of rehabilitation in the children with different length of the lower extremities.

Genetic Structure of Pacific Trout at the Extreme Southern End of Their Native Range

PubMed Central

Abadía-Cardoso, Alicia; Garza, John Carlos; Mayden, Richard L.; García de León, Francisco Javier

2015-01-01

Salmonid fishes are cold water piscivores with a native distribution spanning nearly the entire temperate and subarctic northern hemisphere. Trout in the genus Oncorhynchus are the most widespread salmonid fishes and are among the most important fish species in the world, due to their extensive use in aquaculture and valuable fisheries. Trout that inhabit northwestern Mexico are the southernmost native salmonid populations in the world, and the least studied in North America. They are unfortunately also facing threats to their continued existence. Previous work has described one endemic species, the Mexican golden trout (O. chrysogaster), and one endemic subspecies, Nelson’s trout (O. mykiss nelsoni), in Mexico, but previous work indicated that there is vastly more biodiversity in this group than formally described. Here we conducted a comprehensive genetic analysis of this important group of fishes using novel genetic markers and techniques to elucidate the biodiversity of trout inhabiting northwestern Mexico, examine genetic population structure of Mexican trout and their relationships to other species of Pacific trout, and measure introgression from non-native hatchery rainbow trout. We confirmed substantial genetic diversity and extremely strong genetic differentiation present in the Mexican trout complex, not only between basins but also between some locations within basins, with at least four species-level taxa present. We also revealed significant divergence between Mexican trout and other trout species and found that introgression from non-native rainbow trout is present but limited, and that the genetic integrity of native trout is still maintained in most locations. This information will help to guide effective conservation strategies for this important group of fishes. PMID:26509445

HST Imaging of the Eye of Horus, a Double Source Plane Gravitational Lens

NASA Astrophysics Data System (ADS)

Wong, Kenneth

2017-08-01

Double source plane (DSP) gravitational lenses are extremely rare alignments of a massive lens galaxy with two background sources at distinct redshifts. The presence of two source planes provides important constraints on cosmology and galaxy structure beyond that of typical lens systems by breaking degeneracies between parameters that vary with source redshift. While these systems are extremely valuable, only a handful are known. We have discovered the first DSP lens, the Eye of Horus, in the Hyper Suprime-Cam survey and have confirmed both source redshifts with follow-up spectroscopy, making this the only known DSP lens with both source redshifts measured. Furthermore, the brightest image of the most distant source (S2) is split into a pair of images by a mass component that is undetected in our ground-based data, suggesting the presence of a satellite or line-of-sight galaxy causing this splitting. In order to better understand this system and use it for cosmology and galaxy studies, we must construct an accurate lens model, accounting for the lensing effects of both the main lens galaxy and the intermediate source. Only with deep, high-resolution imaging from HST/ACS can we accurately model this system. Our proposed multiband imaging will clearly separate out the two sources by their distinct colors, allowing us to use their extended surface brightness distributions as constraints on our lens model. These data may also reveal the satellite galaxy responsible for the splitting of the brightest image of S2. With these observations, we will be able to take full advantage of the wealth of information provided by this system.

Beyond Coordination: Joint Planning and Program Execution. The IHPRPT Materials Working Group

NASA Technical Reports Server (NTRS)

Stropki, Michael A.; Cleyrat, Danial A.; Clinton, Raymond G., Jr.; Rogacki, John R. (Technical Monitor)

2000-01-01

"Partnership is more than just coordination," stated then-Commander of the Air Force Research Laboratory (AFRL), Major General Dick Paul (USAF-Ret), at this year's National Space and Missile Materials Symposium. His comment referred to the example of the joint planning and program execution provided by the Integrated High Payoff Rocket Propulsion Technology (IHPRPT) Materials Working Group (IMWG). Most people agree that fiscal pressures imposed by shrinking budgets have made it extremely difficult to build upon our existing technical capabilities. In times of sufficient budgets, building advanced systems poses no major difficulties. However, with today's budgets, realizing enhanced capabilities and developing advanced systems often comes at an unaffordable cost. Overcoming this problem represents both a challenge and an opportunity to develop new business practices that allow us to develop advanced technologies within the restrictions imposed by current funding levels. Coordination of technology developments between different government agencies and organizations is a valuable tool for technology transfer. However, rarely do the newly developed technologies have direct applicability to other ongoing programs. Technology requirements are typically determined up-front during the program planning stage so that schedule risk can be minimized. The problem with this process is that the costs associated with the technology development are often borne by a single program. Additionally, the potential exists for duplication of technical effort. Changing this paradigm is a difficult process but one that can be extremely worthwhile should the right opportunity arise. The IMWG is one such example where NASA, the DoD, and industry have developed joint requirements that are intended to satisfy multiple program needs. More than mere coordination, the organizations comprising the group come together as partners, sharing information and resources, proceeding from a joint roadmap.

Social Case-work in General Practice: An Alternative Approach

PubMed Central

Ratoff, L.; Pearson, Barbara

1970-01-01

During a two-year period a senior case-worker was seconded by a voluntary family case-work agency, the Liverpool Personal Service Society, to work with three general practitioners. The commonest reasons for referral of the 157 new patients to the social worker over this study period were extreme poverty; housing, matrimonial, and psychiatric problems; and problems of fatherless families. The successful and valuable co-operation between the general practitioners, case-worker, and various specialist professional and financial services of the Society have proved that a professional social worker has an important role in the general-practice team. PMID:5420213

Gravity and Magnetic Anomalies of the Sierra Madera, Texas, "Dome".

PubMed

Van Lopik, J R; Geyer, R A

1963-10-04

A geophysical traverse across the Sierra Madera "Dome" indicates a negative gravity anomaly of 1(1/2) milligals over the zone of brecciation in the center and a residual positive anomaly of (1/2) milligal associated with a positive magnetic anomaly of 25 x 10(-5) oersted to the southeast of the zone of brecciation. Areal surveys are needed before any definite conclusions can be drawn concerning the origin of Sierra Madera. However, gravity and magnetic data can be extremely valuable in establishing criteria for classifying terrestrial and lunar features according to meteoritic and cryptovolcanic origin.

Why I think Computational Physics has been the most valuable part of my undergraduate physics education

NASA Astrophysics Data System (ADS)

Parsons, Matthew

2015-04-01

Computational physics is a rich and vibrant field in its own right, but often not given the attention that it should receive in the typical undergraduate physics curriculum. It appears that the partisan theorist vs. experimentalist view is still pervasive in academia, or at least still portrayed to students, while in fact there is a continuous spectrum of opportunities in between these two extremes. As a case study, I'll give my perspective as a graduating physics student with examples of computational coursework at Drexel University and research opportunities that this experience has led to.

Recent trends and important developments in propolis research

PubMed Central

2005-01-01

The newest developments in propolis pharmacological research are summarized. The problem regarding biological studies, caused by the chemical variability of propolis, is discussed. The most important trends and developments in recent propolis research are outlined: biological studies performed with chemically characterized samples, bioassay-guided studies of active principles and comparative biological studies of propolis of different origin and chemical composition. These types of studies are extremely valuable with respect to propolis standardization and practical applications in therapy. They will allow scientists to connect a particular chemical propolis type to a specific type of biological activity and formulate recommendations for practitioners. PMID:15841275

Fast and accurate modeling of nonlinear pulse propagation in graded-index multimode fibers.

PubMed

Conforti, Matteo; Mas Arabi, Carlos; Mussot, Arnaud; Kudlinski, Alexandre

2017-10-01

We develop a model for the description of nonlinear pulse propagation in multimode optical fibers with a parabolic refractive index profile. It consists of a 1+1D generalized nonlinear Schrödinger equation with a periodic nonlinear coefficient, which can be solved in an extremely fast and efficient way. The model is able to quantitatively reproduce recently observed phenomena like geometric parametric instability and broadband dispersive wave emission. We envisage that our equation will represent a valuable tool for the study of spatiotemporal nonlinear dynamics in the growing field of multimode fiber optics.

Matrices pattern using FIB; 'Out-of-the-box' way of thinking.

PubMed

Fleger, Y; Gotlib-Vainshtein, K; Talyosef, Y

2017-03-01

Focused ion beam (FIB) is an extremely valuable tool in nanopatterning and nanofabrication for potentially high-resolution patterning, especially when refers to He ion beam microscopy. The work presented here demonstrates an 'out-of-the-box' method of writing using FIB, which enables creating very large matrices, up to the beam-shift limitation, in short times and with high accuracy unachievable by any other writing technique. The new method allows combining different shapes in nanometric dimensions and high resolutions for wide ranges. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Quantifying crowd size with mobile phone and Twitter data

PubMed Central

Botta, Federico; Moat, Helen Susannah; Preis, Tobias

2015-01-01

Being able to infer the number of people in a specific area is of extreme importance for the avoidance of crowd disasters and to facilitate emergency evacuations. Here, using a football stadium and an airport as case studies, we present evidence of a strong relationship between the number of people in restricted areas and activity recorded by mobile phone providers and the online service Twitter. Our findings suggest that data generated through our interactions with mobile phone networks and the Internet may allow us to gain valuable measurements of the current state of society. PMID:26064667

Test Expectancy and Memory for Important Information

ERIC Educational Resources Information Center

Middlebrooks, Catherine D.; Murayama, Kou; Castel, Alan D.

2017-01-01

Prior research suggests that learners study and remember information differently depending upon the type of test they expect to later receive. The current experiments investigate how testing expectations impact the study of and memory for valuable information. Participants studied lists of words ranging in value from 1 to 10 points with the goal…

Application of data on climate extremes for the southwestern United States

NASA Astrophysics Data System (ADS)

Redmond, K. T.; Fleishman, E.; Cayan, D. R.; Daudert, B.; Gershunov, A.

2015-12-01

We are improving the scientific capacity to evaluate responses of natural resources to climate extremes. We also are enhancing a platform for derivation of and access to customized climate information for the full extent or any subset of the southwestern United States. Extreme climate can have substantial effects on species, ecological and evolutionary processes, and the health of visitors to public lands. We are working with federal and state managers and with researchers who collaborate with decision-makers to use data on climate extremes to inform resource management. Current applications include sudden oak death, estuarine management, and fine-resolution manipulation of montane vegetation. To facilitate practical use of data on climate extremes, we are screening global climate models on the basis of their realism in representing natural regional patterns and extremes of temperature and precipitation, including those driven by El Niño and La Niña. We are assessing how well each model represents different climate elements. We also are delivering point and gridded observations and downscaled model projections, all at daily and 6 km resolution, on past and future climate extremes. Additionally, we are using the downscaled outputs to drive a hydrologic model and derive multiple probabilistic measures of water availability, flood, and drought. Moreover, we are extending the capacity of the Southwest Climate and Environmental Information Collaborative (SCENIC; wrcc.dri.edu/csc/scenic), a product developed by the Western Regional Climate Center, to provide access to diverse observed and simulated data on regional weather and climate, particularly on extremes.

System Analysis and Design of a Low-Cost Micromechanical Seeker System

DTIC Science & Technology

2008-06-01

reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching...who devoted a valuable amount of time to advising me with academic coursework as well as thesis research. Dan, your attention to detail and ability...never have come to be. Many thanks to Sean George, who sacrificed his valuable time to guide me through constructing the projectile flight simulation

Characterizing the growth to detonation in HNS with small-scale PDV "cutback" experiments

NASA Astrophysics Data System (ADS)

Wixom, Ryan R.; Yarrington, Cole D.; Knepper, Robert; Tappan, Alexander S.; Olles, Joseph D.; Damm, David L.

2017-01-01

For many decades, cutback experiments have been used to characterize the equation of state and growth to steady detonation in explosive formulations. More recently, embedded gauges have been used to capture the growth to steady detonation in gas-gun impacted samples. Data resulting from these experiments are extremely valuable for parameterizing equation of state and reaction models used in hydrocode simulations. Due to the extremely fast growth to detonation in typical detonator explosives, cutback and embedded gauge experiments are particularly difficult, if not impossible. Using frequency shifted photonic Doppler velocimetry (PDV) we have measured particle velocity histories from vapor-deposited explosive films impacted with electrically driven flyers. By varying the sample thickness and impact conditions we were able to capture the growth from inert shock to full detonation pressure within distances as short as 100 µm. These data are being used to assess and improve burn-model parameterization and equations of state for simulating shock initiation.

Porosity estimation by semi-supervised learning with sparsely available labeled samples

NASA Astrophysics Data System (ADS)

Lima, Luiz Alberto; Görnitz, Nico; Varella, Luiz Eduardo; Vellasco, Marley; Müller, Klaus-Robert; Nakajima, Shinichi

2017-09-01

This paper addresses the porosity estimation problem from seismic impedance volumes and porosity samples located in a small group of exploratory wells. Regression methods, trained on the impedance as inputs and the porosity as output labels, generally suffer from extremely expensive (and hence sparsely available) porosity samples. To optimally make use of the valuable porosity data, a semi-supervised machine learning method was proposed, Transductive Conditional Random Field Regression (TCRFR), showing good performance (Görnitz et al., 2017). TCRFR, however, still requires more labeled data than those usually available, which creates a gap when applying the method to the porosity estimation problem in realistic situations. In this paper, we aim to fill this gap by introducing two graph-based preprocessing techniques, which adapt the original TCRFR for extremely weakly supervised scenarios. Our new method outperforms the previous automatic estimation methods on synthetic data and provides a comparable result to the manual labored, time-consuming geostatistics approach on real data, proving its potential as a practical industrial tool.

Preventing Terrorism Using Information Sharing Networks

DTIC Science & Technology

2006-09-01

in fusing information and providing valuable intelligence that thwarted a terrorist attack at Disneyland . A videotape was received that contained a...creditable threat of a Sarin gas attack at Disneyland . The LA TEW conducted the initial analysis of the tape and the initial investigation that

Can Computers Create?

ERIC Educational Resources Information Center

Hausman, Carl R.

1985-01-01

To be creative, an act must have as its outcome something new in the way it is intelligible and valuable. Computers have restricted contexts of information and have no ability to weigh bits of information. Computer optimists presuppose either determinism or indeterminism, either of which abandons creativity. (MT)

Extracting meaning from astronomical telegrams

NASA Astrophysics Data System (ADS)

Graham, Matthew; Conwill, L.; Djorgovski, S. G.; Mahabal, A.; Donalek, C.; Drake, A.

2011-01-01

The rapidly emerging field of time domain astronomy is one of the most exciting and vibrant new research frontiers, ranging in scientific scope from studies of the Solar System to extreme relativistic astrophysics and cosmology. It is being enabled by a new generation of large synoptic digital sky surveys - LSST, PanStarrs, CRTS - that cover large areas of sky repeatedly, looking for transient objects and phenomena. One of the biggest challenges facing these is the automated classification of transient events, a process that needs machine-processible astronomical knowledge. Semantic technologies enable the formal representation of concepts and relations within a particular domain. ATELs (http://www.astronomerstelegram.org) are a commonly-used means for reporting and commenting upon new astronomical observations of transient sources (supernovae, stellar outbursts, blazar flares, etc). However, they are loose and unstructured and employ scientific natural language for description: this makes automated processing of them - a necessity within the next decade with petascale data rates - a challenge. Nevertheless they represent a potentially rich corpus of information that could lead to new and valuable insights into transient phenomena. This project lies in the cutting-edge field of astrosemantics, a branch of astroinformatics, which applies semantic technologies to astronomy. The ATELs have been used to develop an appropriate concept scheme - a representation of the information they contain - for transient astronomy using aspects of natural language processing. We demonstrate that it is possible to infer the subject of an ATEL from the vocabulary used and to identify previously unassociated reports.

Current State of Climate Education in the United States: Are Graduate Students being Adequately Prepared to Address Climate Issues?

NASA Astrophysics Data System (ADS)

Kuster, E.; Fox, G.

2016-12-01

Climate change is happening; scientists have already observed changes in sea level, increases in atmospheric carbon dioxide, and declining polar ice. The students of today are the leaders of tomorrow, and it is our duty to make sure they are well equipped and they understand the implications of climate change as part of their research and professional careers. Graduate students, in particular, are gaining valuable and necessary research, leadership, and critical thinking skills, but we need to ensure that they are receiving the appropriate climate education in their graduate training. Previous studies have primarily focused on capturing the K-12, college level, and general publics' knowledge of the climate system, concluding with recommendations on how to improve climate literacy in the classroom. While this is extremely important to study, very few studies have captured the current perception that graduate students hold regarding the amount of climate education being offered to them. This information is important to capture, as it can inform future curriculum development. We developed and distributed a nationwide survey (495 respondents) for graduate students to capture their perception on the level of climate system education being offered and their view on the importance of having climate education. We also investigated differences in the responses based on either geographic area or discipline. We compared how important graduate students felt it was to include climate education in their own discipline versus outside disciplines. The authors will discuss key findings from this ongoing research.

Automated delineation of radiotherapy volumes: are we going in the right direction?

PubMed Central

Whitfield, G A; Price, P; Price, G J; Moore, C J

2013-01-01

ABSTRACT. Rapid and accurate delineation of target volumes and multiple organs at risk, within the enduring International Commission on Radiation Units and Measurement framework, is now hugely important in radiotherapy, owing to the rapid proliferation of intensity-modulated radiotherapy and the advent of four-dimensional image-guided adaption. Nevertheless, delineation is still generally clinically performed with little if any machine assistance, even though it is both time-consuming and prone to interobserver variation. Currently available segmentation tools include those based on image greyscale interrogation, statistical shape modelling and body atlas-based methods. However, all too often these are not able to match the accuracy of the expert clinician, which remains the universally acknowledged gold standard. In this article we suggest that current methods are fundamentally limited by their lack of ability to incorporate essential human clinical decision-making into the underlying models. Hybrid techniques that utilise prior knowledge, make sophisticated use of greyscale information and allow clinical expertise to be integrated are needed. This may require a change in focus from automated segmentation to machine-assisted delineation. Similarly, new metrics of image quality reflecting fitness for purpose would be extremely valuable. We conclude that methods need to be developed to take account of the clinician's expertise and honed visual processing capabilities as much as the underlying, clinically meaningful information content of the image data being interrogated. We illustrate our observations and suggestions through our own experiences with two software tools developed as part of research council-funded projects. PMID:23239689

Comparing SMAP to Macro-scale and Hyper-resolution Land Surface Models over Continental U. S.

NASA Astrophysics Data System (ADS)

Pan, Ming; Cai, Xitian; Chaney, Nathaniel; Wood, Eric

2016-04-01

SMAP sensors collect moisture information in top soil at the spatial resolution of ~40 km (radiometer) and ~1 to 3 km (radar, before its failure in July 2015). Such information is extremely valuable for understanding various terrestrial hydrologic processes and their implications on human life. At the same time, soil moisture is a joint consequence of numerous physical processes (precipitation, temperature, radiation, topography, crop/vegetation dynamics, soil properties, etc.) that happen at a wide range of scales from tens of kilometers down to tens of meters. Therefore, a full and thorough analysis/exploration of SMAP data products calls for investigations at multiple spatial scales - from regional, to catchment, and to field scales. Here we first compare the SMAP retrievals to the Variable Infiltration Capacity (VIC) macro-scale land surface model simulations over the continental U. S. region at 3 km resolution. The forcing inputs to the model are merged/downscaled from a suite of best available data products including the NLDAS-2 forcing, Stage IV and Stage II precipitation, GOES Surface and Insolation Products, and fine elevation data. The near real time VIC simulation is intended to provide a source of large scale comparisons at the active sensor resolution. Beyond the VIC model scale, we perform comparisons at 30 m resolution against the recently developed HydroBloks hyper-resolution land surface model over several densely gauged USDA experimental watersheds. Comparisons are also made against in-situ point-scale observations from various SMAP Cal/Val and field campaign sites.

Putting Citizen-Collected Observations to Work -- The Community Collaborative Rain, Hail and Snow Network (CoCoRaHS)

NASA Astrophysics Data System (ADS)

Doesken, N.

2015-12-01

When CoCoRaHS was born (1998), climate-relevant information was far from our minds. We were simply enlisting volunteers to help capture, display and communicate the nature of small scale variability within northern Colorado storms. Climate change was talked about then, but not with the sense of concern and urgency as today. Now, many years later, the simple back-yard precipitation measurements being taken by thousands of volunteers across much of North America are creating valuable and easily-accessible data and information serving many and varied purposes from federal and state climate monitoring to drought and extreme storm analysis and research. Many volunteers have been with the project now for a decade or longer and have contributed literally thousands of individual observations and reports. Long-time participants along with recent recruits of all ages are seeing first-hand how day by day observations of weather conditions combine - over time and space -- to define and describe key elements of our climate and its variations. The fact that the data from volunteers are frequently used and applied by scientists and decision makers is one of the key factors in retaining long-term volunteers. Examples will be presented of volunteer precipitation data being used both independently and in combination with data from federal monitoring systems. Challenges of maintaining a large volunteer network will be discussed along with some plans and opportunities for the future.

Modeling α- and β-diversity in a tropical forest from remotely sensed and spatial data

NASA Astrophysics Data System (ADS)

Hernández-Stefanoni, J. Luis; Gallardo-Cruz, J. Alberto; Meave, Jorge A.; Rocchini, Duccio; Bello-Pineda, Javier; López-Martínez, J. Omar

2012-10-01

Comprehensive information on species distribution and species composition patterns of plant communities is required for effective conservation and management of biodiversity. Remote sensing offers an inexpensive means of attaining complete spatial coverage for large areas, at regular time intervals, and can therefore be extremely useful for estimating both species richness and spatial variation of species composition (α- and β-diversity). An essential step to map such attributes is to identify and understand their main drivers. We used remotely sensed data as a surrogate of plant productivity and habitat structure variables for explaining α- and β-diversity, and evaluated the relative roles of productivity-habitat structure and spatial variables in explaining observed patterns of α- and β-diversity by using a Principal Coordinates of Neighbor Matrices analysis. We also examined the relationship between remotely sensed and field data, in order to map α- and β-diversity at the landscape-level in the Yucatan Peninsula, using a regression kriging procedure. These two procedures integrate the relationship of species richness and spatial species turnover both with remotely sensed data and spatial structure. The empirical models so obtained can be used to predict species richness and variation in species composition, and they can be regarded as valuable tools not only for identifying areas with high local species richness (α-diversity), but also areas with high species turnover (β-diversity). Ultimately, information obtained in this way can help maximize the number of species preserved in a landscape.

Water quality, isoscapes and stoichioscapes of seagrasses indicate general P limitation and unique N cycling in shallow water benthos of Bermuda

NASA Astrophysics Data System (ADS)

Fourqurean, J. W.; Manuel, S. A.; Coates, K. A.; Kenworthy, W. J.; Boyer, J. N.

2015-07-01

Striking spatial patterns in stable isotope ratios (isoscapes) and elemental ratios (stoichioscapes) of seagrass leaves and the water column nutrients indicate general P-limitation of both water column and benthic primary productivity on the Bermuda Platform, and they highlight the role of the Bermuda Islands as a source of N and P. We found consistent differences among the four seagrass species (Syringodium filiforme, Thalassia testudinum, Halodule sp. and Halophila decipiens) in the N, P, δ13C and δ15N of leaf tissues. The δ15N of seagrass leaves was especially variable, with values from -10.1 to 8.8‰, greatly expanding the reported range of values for all seagrass species globally. Spatial patterns from both the water column and the seagrass leaves indicated that P availability was higher near shore, and δ15N values suggest this was likely a result of human waste disposal. Spatially-contiguous areas of extremely depleted seagrass δ15N suggest unique N sources and cycling compared to other seagrass-dominated environments. Seagrass N : P values were not as far from the stoichiometric balance between N and P availability as in the water column, and there were no strong relationships between the water column N : P and the seagrass N : P. Such isoscapes and stoichioscapes provide valuable ecogeochemical tools to infer ecosystem processes as well as provide information that can inform food web and animal movement studies.

Water quality, isoscapes and stoichioscapes of seagrasses indicate general P limitation and unique N cycling in shallow water benthos of Bermuda

NASA Astrophysics Data System (ADS)

Fourqurean, J. W.; Manuel, S. A.; Coates, K. A.; Kenworthy, W. J.; Boyer, J. N.

2015-10-01

Striking spatial patterns in stable isotope ratios (isoscapes) and elemental ratios (stoichioscapes) of seagrass leaves and the water column nutrients indicate general P-limitation of both water column and benthic primary productivity on the Bermuda Platform, and they highlight the role of the Bermuda Islands as a source of N and P. We found consistent differences among the four seagrass species (Syringodium filiforme, Thalassia testudinum, Halodule sp. and Halophila decipiens) in the N, P, δ13C and δ15N of leaf tissues. The δ15N of seagrass leaves was especially variable, with values from -10.1 to 8.8 ‰, greatly expanding the reported range of values for all seagrass species globally. Spatial patterns from both the water column and the seagrass leaves indicated that P availability was higher near shore, and δ15N values suggest this was likely a result of human waste disposal. Spatially contiguous areas of extremely depleted seagrass 15N suggest unique N sources and cycling compared to other seagrass-dominated environments. Seagrass N : P values were not as far from the stoichiometric balance between N and P availability as in the water column, and there were no strong relationships between the water column N : P and the seagrass N : P. Such isoscapes and stoichioscapes provide valuable ecogeochemical tools to infer ecosystem processes as well as provide information that can inform food web and animal movement studies.

Anthropogenic influences on the Preservation of Ancient Tsunami Deposits

NASA Astrophysics Data System (ADS)

Goodman-Tchernov, Beverly

2017-04-01

Deposits and damage on the landscape immediately following a tsunami event are subject to a range of post-depositional alterations driven by natural and anthropogenic processes, ultimately ending in extremely differential preservation that complicates efforts to find and interpret ancient and paleotsunami remains. Along the Israeli Mediterranean coastline, offshore tsunami sediment research has offered a reconstruction of multiple events, but the onshore record has proved challenging due to post-event clean-up, coastal development, and natural erosion. Archaeological excavations in the last half century have also removed a large portion of sediments that might have assisted in the effort. Archival photographs, field descriptions, and newly excavated areas were investigated in light of the offshore and historical evidence for tsunamis. Unique deposits from those records and from newly exposed areas present new information that illustrate circumstances in which a deposit is well-preserved and where it is not. A trend is apparent in which areas which are under heavy use at the time of the event are more likely to be renovated, rebuilt, or otherwise changed post-event; leaving less fingerprint behind, while better preservation of the deposit is present in already neglected or less functioning areas. Also, in some cases field evidence that is seemingly contradictory to the presence of a disaster is, in fact, an acute marker of the event. Worldwide, past tsunami deposit field evidence is a valuable database for better informing estimates and models of potential future events; and therefore such improvements in field identification are important.

Terrestrial ecology of semi-aquatic giant gartersnakes (Thamnophis gigas)

USGS Publications Warehouse

Halstead, Brian J.; Skalos, Shannon M.; Wylie, Glenn D.; Casazza, Michael L.

2015-01-01

Wetlands are a vital component of habitat for semiaquatic herpetofauna, but for most species adjacent terrestrial habitats are also essential. We examined the use of terrestrial environments by Giant Gartersnakes (Thamnophis gigas) to provide behavioral information relevant to conservation of this state and federally listed threatened species. We used radio telemetry data collected 1995–2011 from adults at several sites throughout the Sacramento Valley, California, USA, to examine Giant Gartersnake use of the terrestrial environment. We found Giant Gartersnakes in terrestrial environments more than half the time during the summer, with the use of terrestrial habitats increasing to nearly 100% during brumation. While in terrestrial habitats, we found Giant Gartersnakes underground more than half the time in the early afternoon during summer, and the probability of being underground increased to nearly 100% of the time at all hours during brumation. Extreme temperatures also increased the probability that we would find Giant Gartersnakes underground. Under most conditions, we found Giant Gartersnakes to be within 10 m of water at 95% of observations. For females during brumation and individuals that we found underground, however, the average individual had a 10% probability of being located > 20 m from water. Individual variation in each of the response variables was extensive; therefore, predicting the behavior of an individual was fraught with uncertainty. Nonetheless, our estimates provide resource managers with valuable information about the importance of protecting and carefully managing terrestrial habitats for conserving a rare semiaquatic snake.

Validation of extremes within the Perfect-Predictor Experiment of the COST Action VALUE

NASA Astrophysics Data System (ADS)

Hertig, Elke; Maraun, Douglas; Wibig, Joanna; Vrac, Mathieu; Soares, Pedro; Bartholy, Judith; Pongracz, Rita; Mares, Ileana; Gutierrez, Jose Manuel; Casanueva, Ana; Alzbutas, Robertas

2016-04-01

Extreme events are of widespread concern due to their damaging consequences on natural and anthropogenic systems. From science to applications the statistical attributes of rare and infrequent occurrence and low probability become connected with the socio-economic aspect of strong impact. Specific end-user needs regarding information about extreme events depend on the type of application, but as a joining element there is always the request for easily accessible climate change information with a clear description of their uncertainties and limitations. Within the Perfect-Predictor Experiment of the COST Action VALUE extreme indices modelled from a wide range of downscaling methods are compared to reference indices calculated from observational data. The experiment uses reference data from a selection of 86 weather stations representative of the different climates in Europe. Results are presented for temperature and precipitation extremes and include aspects of the marginal distribution as well as spell-length related aspects.

Reclaiming the past: Using hierarchical Bayesian analysis to fill missing values in the tide gauge mean sea level record, with application to extreme value analysis

NASA Astrophysics Data System (ADS)

Piecuch, C. G.; Huybers, P. J.; Tingley, M.

2015-12-01

Tide gauge records of mean sea level are some of the most valuable instrumental time series of oceanic variability and change. Yet these time series sometimes have short record lengths and intermittently missing values. Such issues can limit the utility of the data, for example, precluding rigorous analyses of return periods of extreme mean sea level events and whether they are unprecedented. With a view to filling gaps in the tide gauge mean sea level time series, we describe a hierarchical Bayesian modeling approach. The model, which is predicated on the notion of conditional probabilities, comprises three levels: a process level, which casts mean sea level as a field with spatiotemporal covariance; a data level, which represents tide gauge observations as noisy, biased versions of the true process; and a prior level, which gives prior functional forms to model parameters. Using Bayes' rule, this technique gives estimates of the posterior probability of the process and the parameters given the observations. To demonstrate the approach, we apply it to 2,967 station-years of annual mean sea level observations over 1856-2013 from 70 tide gauges along the United States East Coast from Florida to Maine (i.e., 26.8% record completeness). The model overcomes the data paucity by sharing information across space and time. The result is an ensemble of realizations, each member of which is a possible history of sea level changes at these locations over this period, which is consistent with and equally likely given the tide gauge data and underlying model assumptions. Using the ensemble of histories furnished by the Bayesian model, we identify extreme events of mean sea level change in the tide gauge time series. Specifically, we use the model to address the particular hypothesis (with rigorous uncertainty quantification) that a recently reported interannual sea level rise during 2008-2010 was unprecedented in the instrumental record along the northeast coast of North America, and that it had a return period of 850 years. Preliminary analysis suggests that this event was likely unprecedented on the coast of Maine in the last century.

A 2000-year palaeoflood record from northwest England from lake sediments

NASA Astrophysics Data System (ADS)

Schillereff, Daniel; Chiverrell, Richard; Macdonald, Neil; Hooke, Janet

2014-05-01

Greater insight into the relationship between climatic fluctuations and the frequency and magnitude of precipitation events over recent centuries is crucial in the context of future warming and projected intensification of hydrological extremes. However, the detection of trends in flood frequency and intensity is not a straightforward task as conventional flood series derived from instrumental sources rarely span sufficiently long timescales to capture the most extreme events. Usefully, the geomorphic effects of extreme hydrological events can be effectively recorded in upland lake basins as efficient sediment trapping preserves discharge-related proxy indicators (e.g., particle size). Provided distinct sedimentary signatures of historic floods are discernable and the sediment sequence can be well-constrained in time, these lacustrine archives offer a valuable data resource. We demonstrate that a series of sediment cores (3 - 5 m length) from Brotherswater, northwest England, contain numerous coarse-grained laminations, discerned by applying high-resolution (0.5 cm) laser granulometry, which are interpreted as reflecting a palaeoflood record extending to ~2000 yr BP. The presence of thick facies which exhibit inverse grading underlying normal grading, most likely reflecting the waxing and waning of flood-induced hyperpycnal flows, supports our palaeoflood interpretation. Data from an on-going sediment trapping protocol at Brotherswater that shows a relationship between river discharge (recorded via short-term lake level change representing flood events) and the calibre of particles captured in the traps lends further support to our interpretation. Well-constrained chronologies were constructed for the cores through integrating radionuclide (210Pb, 137Cs, 241Am, 14C) dating within a Bayesian age-depth modelling protocol. Geochemical markers of known-age that reflect phases of local point-source lead (Pb) mining were used to resolve time periods where radiocarbon dates returned multiple possible age solutions. We subsequently build a regression model using the time-window where recorded river discharge and the sedimentary record overlap (1961-2013) in order to reconstruct discharge estimates for the palaeoflood laminations. These quantitative palaeoflood data can thus be inserted into statistical flood frequency analyses and compared with outputs using instrumental data and regional flood information.

Lower extremity finite element model for crash simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schauer, D.A.; Perfect, S.A.

1996-03-01

A lower extremity model has been developed to study occupant injury mechanisms of the major bones and ligamentous soft tissues resulting from vehicle collisions. The model is based on anatomically correct digitized bone surfaces of the pelvis, femur, patella and the tibia. Many muscles, tendons and ligaments were incrementally added to the basic bone model. We have simulated two types of occupant loading that occur in a crash environment using a non-linear large deformation finite element code. The modeling approach assumed that the leg was passive during its response to the excitation, that is, no active muscular contraction and thereforemore » no active change in limb stiffness. The approach recognized that the most important contributions of the muscles to the lower extremity response are their ability to define and modify the impedance of the limb. When nonlinear material behavior in a component of the leg model was deemed important to response, a nonlinear constitutive model was incorporated. The accuracy of these assumptions can be verified only through a review of analysis results and careful comparison with test data. As currently defined, the model meets the objective for which it was created. Much work remains to be done, both from modeling and analysis perspectives, before the model can be considered complete. The model implements a modeling philosophy that can accurately capture both kinematic and kinetic response of the lower limb. We have demonstrated that the lower extremity model is a valuable tool for understanding the injury processes and mechanisms. We are now in a position to extend the computer simulation to investigate the clinical fracture patterns observed in actual crashes. Additional experience with this model will enable us to make a statement on what measures are needed to significantly reduce lower extremity injuries in vehicle crashes. 6 refs.« less

Sensory stimulation augments the effects of massed practice training in persons with tetraplegia.

PubMed

Beekhuizen, Kristina S; Field-Fote, Edelle C

2008-04-01

To compare functional changes and cortical neuroplasticity associated with hand and upper extremity use after massed (repetitive task-oriented practice) training, somatosensory stimulation, massed practice training combined with somatosensory stimulation, or no intervention, in persons with chronic incomplete tetraplegia. Participants were randomly assigned to 1 of 4 groups: massed practice training combined with somatosensory peripheral nerve stimulation (MP+SS), somatosensory peripheral nerve stimulation only (SS), massed practice training only (MP), and no intervention (control). University medical school setting. Twenty-four subjects with chronic incomplete tetraplegia. Intervention sessions were 2 hours per session, 5 days a week for 3 weeks. Massed practice training consisted of repetitive practice of functional tasks requiring skilled hand and upper-extremity use. Somatosensory stimulation consisted of median nerve stimulation with intensity set below motor threshold. Pre- and post-testing assessed changes in functional hand use (Jebsen-Taylor Hand Function Test), functional upper-extremity use (Wolf Motor Function Test), pinch grip strength (key pinch force), sensory function (monofilament testing), and changes in cortical excitation (motor evoked potential threshold). The 3 groups showed significant improvements in hand function after training. The MP+SS and SS groups had significant improvements in upper-extremity function and pinch strength compared with the control group, but only the MP+SS group had a significant change in sensory scores compared with the control group. The MP+SS and MP groups had greater change in threshold measures of cortical excitability. People with chronic incomplete tetraplegia obtain functional benefits from massed practice of task-oriented skills. Somatosensory stimulation appears to be a valuable adjunct to training programs designed to improve hand and upper-extremity function in these subjects.

The effect of asymmetrical body orientation during simulated forward falls on the distal upper extremity impact response of healthy people.

PubMed

Burkhart, Timothy A; Brydges, Evan; Stefanczyk, Jennifer; Andrews, David M

2017-04-01

The occurrence of distal upper extremity injuries resulting from forward falls (approximately 165,000 per year) has remained relatively constant for over 20years. Previous work has provided valuable insight into fall arrest strategies, but only symmetric falls in body postures that do not represent actual fall scenarios closely have been evaluated. This study quantified the effect of asymmetric loading and body postures on distal upper extremity response to simulated forward falls. Twenty participants were suspended from the Propelled Upper Limb fall ARest Impact System (PULARIS) in different torso and leg postures relative to the ground and to the sagittal plane (0°, 30° and 45°). When released from PULARIS (hands 10cm above surface, velocity 1m/s), participants landed on two force platforms, one for each hand. Right forearm impact response was measured with distal (radial styloid) and proximal (olecranon) tri-axial accelerometers and bipolar EMG from seven muscles. Overall, the relative height of the torso and legs had little effect on the forces, or forearm response variables. Muscle activation patterns consistently increased from the start to the peak activation levels after impact for all muscles, followed by a rapid decline after peak. The impact forces and accelerations suggest that the distal upper extremity is loaded more medial-laterally during asymmetric falls than symmetric falls. Altering the direction of the impact force in this way (volar-dorsal to medial-lateral) may help reduce distal extremity injuries caused when landing occurs symmetrically in the sagittal plane as it has been shown that volar-dorsal forces increase the risk of injury. Copyright © 2017 Elsevier Ltd. All rights reserved.

Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments.

PubMed

Yang, Ji; Li, Wen-Rong; Lv, Feng-Hua; He, San-Gang; Tian, Shi-Lin; Peng, Wei-Feng; Sun, Ya-Wei; Zhao, Yong-Xin; Tu, Xiao-Long; Zhang, Min; Xie, Xing-Long; Wang, Yu-Tao; Li, Jin-Quan; Liu, Yong-Gang; Shen, Zhi-Qiang; Wang, Feng; Liu, Guang-Jian; Lu, Hong-Feng; Kantanen, Juha; Han, Jian-Lin; Li, Meng-Hua; Liu, Ming-Jun

2016-10-01

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8-9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Web Based Information System for Job Training Activities Using Personal Extreme Programming (PXP)

NASA Astrophysics Data System (ADS)

Asri, S. A.; Sunaya, I. G. A. M.; Rudiastari, E.; Setiawan, W.

2018-01-01

Job training is one of the subjects in university or polytechnic that involves many users and reporting activities. Time and distance became problems for users to reporting and to do obligations tasks during job training due to the location where the job training took place. This research tried to develop a web based information system of job training to overcome the problems. This system was developed using Personal Extreme Programming (PXP). PXP is one of the agile methods is combination of Extreme Programming (XP) and Personal Software Process (PSP). The information system that has developed and tested which are 24% of users are strongly agree, 74% are agree, 1% disagree and 0% strongly disagree about system functionality.

Terrestrial environment (Climatic) criteria guidelines for use in aerospace vehicle development, 1977 revision

NASA Technical Reports Server (NTRS)

Kaufman, J. W. (Editor)

1977-01-01

Guidelines are provided on terrestrial environment data specifically applicable for NASA aerospace vehicles and associated equipment development. Information is included on the general distribution of natural environment extremes in the conterminous United States that may be needed to specify design criteria in the transportation of space vehicle subsystems and components. Atmospheric attenuation was investigated since certain earth orbital experiment missions are influenced by the earth's atmosphere. A summary of climatic extremes for worldwide operational needs is also included. The latest available information on probable climatic extremes is presented with information on atmospheric chemistry, seismic criteria, and on a mathematical model to predict atmospheric dispersion of aerospace engine exhaust cloud rise and growth. Cloud phenomena are also considered.

Shuttle Imaging Radar (SIR-B) investigations of the Canadian shield - Initial Report

NASA Technical Reports Server (NTRS)

Lowman, Paul D., Jr.; Harris, Jeff; Masuoka, Penny M.; Singhroy, Vernon H.; Slaney, Vernon Roy

1987-01-01

Two of the 43 Shuttle Imaging Radar (SIR-B) experiments carried out from the 41-G shuttle mission in 1984 involved a 2600-km swath across the Canadian Shield, with the objectives of studying the structure of province boundaries and developing techniques for the geologic use of orbital radar. Despite degraded single incidence angle imagery resulting from system problems, valuable experience has been obtained with data over a test site near Bancroft, Ontario. It has been found that even subdued glaciated topography can be effectively imaged, variations in backscatter being caused by variations in local incidence angle rather than shadowing. It has been demonstrated that small incidence angles are more sensitive to topography than large angles. Backscatter is extremely sensitive to look direction, topographic features nearly normal to the illumination being highlighted, and those nearly parallel to it being suppressed. It is concluded that orbital radar can provide a valuable tool for geologic studies of the Canadian Shield and similar areas, if suitable look angles and at least two look directions can be utilized for each area.

Advanced eddy current test signal analysis for steam generator tube defect classification and characterization

NASA Astrophysics Data System (ADS)

McClanahan, James Patrick

Eddy Current Testing (ECT) is a Non-Destructive Examination (NDE) technique that is widely used in power generating plants (both nuclear and fossil) to test the integrity of heat exchanger (HX) and steam generator (SG) tubing. Specifically for this research, laboratory-generated, flawed tubing data were examined. The purpose of this dissertation is to develop and implement an automated method for the classification and an advanced characterization of defects in HX and SG tubing. These two improvements enhanced the robustness of characterization as compared to traditional bobbin-coil ECT data analysis methods. A more robust classification and characterization of the tube flaw in-situ (while the SG is on-line but not when the plant is operating), should provide valuable information to the power industry. The following are the conclusions reached from this research. A feature extraction program acquiring relevant information from both the mixed, absolute and differential data was successfully implemented. The CWT was utilized to extract more information from the mixed, complex differential data. Image Processing techniques used to extract the information contained in the generated CWT, classified the data with a high success rate. The data were accurately classified, utilizing the compressed feature vector and using a Bayes classification system. An estimation of the upper bound for the probability of error, using the Bhattacharyya distance, was successfully applied to the Bayesian classification. The classified data were separated according to flaw-type (classification) to enhance characterization. The characterization routine used dedicated, flaw-type specific ANNs that made the characterization of the tube flaw more robust. The inclusion of outliers may help complete the feature space so that classification accuracy is increased. Given that the eddy current test signals appear very similar, there may not be sufficient information to make an extremely accurate (>95%) classification or an advanced characterization using this system. It is necessary to have a larger database fore more accurate system learning.

Fluorometric prediction of successful amputation level in the ischemic limb.

PubMed

Silverman, D G; Rubin, S M; Reilly, C A; Brousseau, D A; Norton, K J; Wolf, G L

1985-01-01

The present study was undertaken to compare fluorometric documentation of fluorescein dye delivery with the standard means of determining the level at which an amputation should be performed in the dysvascular extremity. Thirty-nine patients underwent lower-extremity amputation at the level determined by the surgeon based upon physical examination, angiography, segmental pressure indices, and/or pulse volume recordings. In addition, fiberoptic fluorometry was performed preoperatively. After intravenous administration of sodium fluorescein (4-8 mg/kg), fluorometric readings were obtained by placing the fluorometer's light guide on 126 reading sites. Fluorometric findings were evaluated retrospectively, and therefore did not influence the surgeon's decision. Of the 39 amputations performed overall, only 26 healed. The accuracy of the standard criteria was lowest for the 20 below-ankle amputations, where only 12 cases healed. Alternatively, fluorometric indices separated healing from nonhealing sites in 36 of the 39 cases and in 18 of the 20 below-ankle amputations. Overall, healing sites averaged 94 percent of the fluorescence of the healthy reference area, while nonhealing sites averaged only 29 percent. We conclude that fluorometry should prove to be a valuable adjunct in the assessment of the dysvascular extremity. It uses a low dose of dye, is easy to perform, and is readily repeatable.

Eddy covarianace measurements in a hyper-arid and hyper-saline mangroves ecosystem

NASA Astrophysics Data System (ADS)

Perri, S.; Marpu, P.; Molini, A.; Armstrong, P.

2017-12-01

The natural environment of mangroves provides a number of ecosystem services for improving water quality, supporting healthy fisheries, and protecting the coasts. Also, their carbon storage is larger than any other forest type. Several authors have recognized the importance of mangroves in global carbon cycles. However, energy, water and carbon exchanges between ecosystem and atmosphere are still not completely understood. Eddy covariance measurements are extremely valuable to understand the role of the unique stressors of costal ecosystems in gas exchange. In particular, periodic flooding and elevated soil pore water salinity influence land-atmosphere interactions. Despites the importance of flux measurements in mangroves forests, such in-situ observations are extremely rare. Our research team set up an eddy covariance tower in the Mangrove National Park of Abu Dhabi, UAE. The study site (24.4509° N, 54.4288° E) is located in a dwarf Avicennia marina ecosystem experiencing extremely high temperatures and salinity. CO2 and H2O exchanges are estimated and related to water level and salinity measurements. This unique dataset will shed some light on the net ecosystem exchange (NEE) of carbon dioxide, on energy fluxes and on evapotranspiration rates for a halophyte ecosystem under severe salt-stress and high temperature.

Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations

PubMed Central

Kim, Dae-Hyeong; Song, Jizhou; Choi, Won Mook; Kim, Hoon-Sik; Kim, Rak-Hwan; Liu, Zhuangjian; Huang, Yonggang Y.; Hwang, Keh-Chih; Zhang, Yong-wei; Rogers, John A.

2008-01-01

Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable new biomedical devices and other applications whose requirements are impossible to satisfy with conventional wafer-based technologies or even with those that offer simple bendability. This article introduces materials and mechanical design strategies for classes of electronic circuits that offer extremely high stretchability, enabling them to accommodate even demanding configurations such as corkscrew twists with tight pitch (e.g., 90° in ≈1 cm) and linear stretching to “rubber-band” levels of strain (e.g., up to ≈140%). The use of single crystalline silicon nanomaterials for the semiconductor provides performance in stretchable complementary metal-oxide-semiconductor (CMOS) integrated circuits approaching that of conventional devices with comparable feature sizes formed on silicon wafers. Comprehensive theoretical studies of the mechanics reveal the way in which the structural designs enable these extreme mechanical properties without fracturing the intrinsically brittle active materials or even inducing significant changes in their electrical properties. The results, as demonstrated through electrical measurements of arrays of transistors, CMOS inverters, ring oscillators, and differential amplifiers, suggest a valuable route to high-performance stretchable electronics. PMID:19015528

Using Scaled Visual Texture for Autonomous Rock Clustering

NASA Technical Reports Server (NTRS)

Anderson, R. C.; Castano, R.; Stough, T.; Gor, V.; Mjolsness, E.

2001-01-01

To maximize the return on future planetary missions, it will be critical that rovers have the capability to analyze information onboard and select and return data that is most likely to yield valuable scientific discoveries. Additional information is contained in the original extended abstract.

Competitive Intelligence on the Internet-Going for the Gold.

ERIC Educational Resources Information Center

Kassler, Helene

2000-01-01

Discussion of competitive intelligence (CI) focuses on recent Web sties and several search techniques that provide valuable CI information. Highlights include links that display business relationships; information from vendors; general business sites; search engine strategies; local business newspapers; job postings; patent and trademark…

A Thermal-based Two-Source Energy Balance Model for Estimating Evapotranspiration over Complex Canopies

USDA-ARS?s Scientific Manuscript database

Land surface temperature (LST) provides valuable information for quantifying root-zone water availability, evapotranspiration (ET) and crop condition as well as providing useful information for constraining prognostic land surface models. This presentation describes a robust but relatively simple LS...

Assessing Website Quality in Context: Retrieving Information about Genetically Modified Food on the Web

ERIC Educational Resources Information Center

McInerney, Claire R.; Bird, Nora J.

2005-01-01

Introduction: Knowing the credibility of information about genetically modified food on the Internet is critical to the everyday life information seeking of consumers as they form opinions about this nascent agricultural technology. The Website Quality Evaluation Tool (WQET) is a valuable instrument that can be used to determine the credibility of…

The Use of Information from Wrong Responses in Measuring Students' Achievement.

ERIC Educational Resources Information Center

Birenbaum, Menucha; Tatsuoka, Kikumi K.

Much valuable information can be gained by analyzing the students' wrong responses. When a student answers a free response item she/he gives the response which she/he considers to be the correct one. Therefore, diagnosing the algorithm that led the student to his/her answer provides an important source of information for assessing his/her…

Propagation of Valuable North Sumatera Benzoin Trees (Styrax Sp) Using Macrocutting Technique

NASA Astrophysics Data System (ADS)

Susilowati, A.; Hartini, K. S.; Rachmat, H. H.; Alvaroby, M.

2017-03-01

Kemenyan known as Sumatran benzoin is North Sumatera local species that produce high valuable rosin and prospective export comodities. However, sustainability of Sumatran benzoin production has many constraints such as instability of resin production, lack information of propagation technique and traditional management system. Until now, comprehensive information for Sumatran benzoin propagation system still not determined yet. The objectives of this research were (1) to get information about propagation technique of Sumatran benzoin and its suitable growing medium and 2) to get information on adventitious root formation in Sumatran benzoin cuttings. Cutting materials (Toba benzoin and Durame benzoin) were originated from 1 year old seedling propagated by seed. Media used were combination of sand : rice husk (1:0 v/v; 1/1 v/v). Results showed that interaction between media and benzoin species significantly affected primer and secondary root lenght. While planting medium significantly improved secondary root length and number. Benzoin species significantly affected primary and secondary root lenght, and secondary root number.

Year-round record of Dry Valley soil CO2 flux provides insights into Antarctic soil dynamics

NASA Astrophysics Data System (ADS)

Risk, D. A.; Lee, C.; Macintyre, C. M.; Cary, C.

2012-12-01

The McMurdo Dry Valleys of Antarctica host extreme soil microbial communities that have been extensively studied within the past decade. Activity of microbial communities is routinely measured via soil CO2 flux, and some useful Antarctic measurements have been made during short Austral summers. These studies are mostly spatial in nature, but temporal patterns are also valuable and may provide insights into critical thresholds and the interplay between various mechanisms that drive CO2 flux and its variation. New membrane-based Forced Diffusion (FD) soil efflux techniques offer promise for this application. The purpose of this study was to use a specially designed FD instrument in Hidden Valley of the Antarctic Dry Valleys to evaluate hardware performance in year-round deployments, and to identify features of interest with respect to soil CO2 flux variation. Overall, the deployment was successful. Small but sustained positive fluxes were present only twice during the year. The first such event was small but consistent and of long duration, occurring in the Austral winter. The second was more volatile and likely of microbial origin, and appeared for roughly a month at the end of the calendar year within the Austral summer. The observed patterns suggest that Hidden Valley soil CO2 fluxes are not solely biological in nature, but likely modulated by a combination of biological, geological, and physical processes, which will be discussed in this presentation. In future studies, additional measurement locations, and simultaneous subsurface and lower atmospheric gradient concentration measurements (power-permitting) would be extremely valuable for interpreting measured fluxes, to help identify advective depletion events, the depth source of fluxes, and changes in soil and atmospheric diffusivities.

U.S. Air Force School of Aerospace Medicine Laboratory Sampling and Analysis Guide

DTIC Science & Technology

2016-11-15

valuable information during the environmental health risk assessment.  EPA Integrated Risk Information System (IRIS). IRIS is a human health assessment...information for more than 550 chemical substances containing information on human health effects that may result from exposure to various substances in the...Crystalyn E. Brown November 2016 Air Force Research Laboratory 711th Human Performance Wing School of Aerospace Medicine

The Economics of Information: A Guide to Economic and Cost-Benefit Analysis for Information Professionals. Library and Information Science Text Series.

ERIC Educational Resources Information Center

Kingma, Bruce R.

This book provides readers with an introduction to economics and cost-benefit analysis and will be particularly valuable to individuals who are, or plan to be, managers of information services in academic, public, or special libraries. Part 1 provides a rational for economic studies in librarianship, specifically, gaining understanding of consumer…

Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability.

PubMed

Heye, Anna K; Thrippleton, Michael J; Armitage, Paul A; Valdés Hernández, Maria Del C; Makin, Stephen D; Glatz, Andreas; Sakka, Eleni; Wardlaw, Joanna M

2016-01-15

There is evidence that subtle breakdown of the blood-brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel disease and some dementias. Dynamic contrast-enhanced MRI (DCE-MRI) combined with tracer kinetic modelling is widely used for assessing permeability and perfusion in brain tumours and body tissues where contrast agents readily accumulate in the extracellular space. However, in diseases where leakage is subtle, the optimal approach for measuring BBB integrity is likely to differ since the magnitude and rate of enhancement caused by leakage are extremely low; several methods have been reported in the literature, yielding a wide range of parameters even in healthy subjects. We hypothesised that the Patlak model is a suitable approach for measuring low-level BBB permeability with low temporal resolution and high spatial resolution and brain coverage, and that normal levels of scanner instability would influence permeability measurements. DCE-MRI was performed in a cohort of mild stroke patients (n=201) with a range of cerebral small vessel disease severity. We fitted these data to a set of nested tracer kinetic models, ranking their performance according to the Akaike information criterion. To assess the influence of scanner drift, we scanned 15 healthy volunteers that underwent a "sham" DCE-MRI procedure without administration of contrast agent. Numerical simulations were performed to investigate model validity and the effect of scanner drift. The Patlak model was found to be most appropriate for fitting low-permeability data, and the simulations showed vp and K(Trans) estimates to be reasonably robust to the model assumptions. However, signal drift (measured at approximately 0.1% per minute and comparable to literature reports in other settings) led to systematic errors in calculated tracer kinetic parameters, particularly at low permeabilities. Our findings justify the growing use of the Patlak model in low-permeability states, which has the potential to provide valuable information regarding BBB integrity in a range of diseases. However, absolute values of the resulting tracer kinetic parameters should be interpreted with extreme caution, and the size and influence of signal drift should be measured where possible. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability

PubMed Central

Heye, Anna K.; Thrippleton, Michael J.; Armitage, Paul A.; Valdés Hernández, Maria del C.; Makin, Stephen D.; Glatz, Andreas; Sakka, Eleni; Wardlaw, Joanna M.

2016-01-01

There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel disease and some dementias. Dynamic contrast-enhanced MRI (DCE-MRI) combined with tracer kinetic modelling is widely used for assessing permeability and perfusion in brain tumours and body tissues where contrast agents readily accumulate in the extracellular space. However, in diseases where leakage is subtle, the optimal approach for measuring BBB integrity is likely to differ since the magnitude and rate of enhancement caused by leakage are extremely low; several methods have been reported in the literature, yielding a wide range of parameters even in healthy subjects. We hypothesised that the Patlak model is a suitable approach for measuring low-level BBB permeability with low temporal resolution and high spatial resolution and brain coverage, and that normal levels of scanner instability would influence permeability measurements. DCE-MRI was performed in a cohort of mild stroke patients (n = 201) with a range of cerebral small vessel disease severity. We fitted these data to a set of nested tracer kinetic models, ranking their performance according to the Akaike information criterion. To assess the influence of scanner drift, we scanned 15 healthy volunteers that underwent a “sham” DCE-MRI procedure without administration of contrast agent. Numerical simulations were performed to investigate model validity and the effect of scanner drift. The Patlak model was found to be most appropriate for fitting low-permeability data, and the simulations showed vp and KTrans estimates to be reasonably robust to the model assumptions. However, signal drift (measured at approximately 0.1% per minute and comparable to literature reports in other settings) led to systematic errors in calculated tracer kinetic parameters, particularly at low permeabilities. Our findings justify the growing use of the Patlak model in low-permeability states, which has the potential to provide valuable information regarding BBB integrity in a range of diseases. However, absolute values of the resulting tracer kinetic parameters should be interpreted with extreme caution, and the size and influence of signal drift should be measured where possible. PMID:26477653

Gaining the Patient Reported Outcomes Measurement Information System (PROMIS) Perspective in Chronic Kidney Disease: a Midwest Pediatric Nephrology Consortium study

PubMed Central

Selewski, David T.; Massengill, Susan F.; Troost, Jonathan P.; Wickman, Larysa; Messer, Kassandra L.; Herreshoff, Emily; Bowers, Corinna; Ferris, Maria E.; Mahan, John D.; Greenbaum, Larry A.; MacHardy, Jackie; Kapur, Gaurav; Chand, Deepa H.; Goebel, Jens; Barletta, Gina Marie; Geary, Denis; Kershaw, David B.; Pan, Cynthia G.; Gbadegesin, Rasheed; Hidalgo, Guillermo; Lane, Jerome C.; Leiser, Jeffrey D.; Song, Peter X.; Thissen, David; Liu, Yang; Gross, Heather E.; DeWalt, Darren A.; Gipson, Debbie S.

2014-01-01

Background and Objectives Chronic kidney disease is a persistent chronic health condition commonly seen in pediatric nephrology programs. Our study aims to evaluate the sensitivity of the Patient Reported Outcomes Measurement Information System (PROMIS) pediatric instrument to indicators of disease severity and activity in pediatric chronic kidney disease. Methods This cross sectional study included 233 children 8–17 years old with chronic kidney disease from 16 participating institutions in North America. Disease activity indicators, including hospitalization in the previous 6 months, edema, and number of medications consumed daily, as well as disease severity indicators of kidney function and coexisting medical conditions were captured. PROMIS domains, including depression, anxiety, social-peer relationships, pain interference, fatigue, mobility, and upper extremity function, were administered via web-based questionnaires. Absolute effect sizes (AES) were generated to demonstrate the impact of disease on domain scores. Four children were excluded because of missing GFR estimations. Results 221 of the 229 children included in the final analysis completed the entire PROMIS questionnaire. Unadjusted PROMIS domains were responsive to chronic kidney disease activity indicators and number of coexisting conditions. PROMIS domain scores were worse in the presence of recent hospitalizations (depression AES 0.33, anxiety AES 0.42, pain interference AES 0.46, fatigue AES 0.50, mobility AES 0.49), edema (depression AES 0.50, anxiety AES 0.60, pain interference AES 0.77, mobility AES 0.54) and coexisting medical conditions (social peer-relationships AES 0.66, fatigue AES 0.83, mobility AES 0.60, upper extremity function AES 0.48). Conclusions The PROMIS pediatric domains of depression, anxiety, social-peer relationships, pain interference, and mobility were sensitive to the clinical status of children with chronic kidney disease in this multi-center cross sectional study. We demonstrated that a number of important clinical characteristics including recent history of hospitalization and edema affected patient perceptions of depression, anxiety, pain interference, fatigue and mobility. The PROMIS instruments provide a potentially valuable tool to study the impact of chronic kidney disease. Additional studies will be required to assess responsiveness in PROMIS score with changes in disease status over time. PMID:24908324

Lens proteome map and alpha-crystallin profile of the catfish Rita rita.

PubMed

Mohanty, Bimal Prasanna; Bhattacharjee, Soma; Das, Manas Kumar

2011-02-01

Crystallins are a diverse group of proteins that constitute nearly 90% of the total soluble proteins of the vertebrate eye lens and these tightly packed crystallins are responsible for transparency of the lens. These proteins have been studied in different model and non-model species for understanding the modifications they undergo with ageing that lead to cataract, a disease of protein aggregation. In the present investigation, we studied the lens crystallin profile of the tropical freshwater catfish Rita rita. Profiles of lens crystallins were analyzed and crystallin proteome maps of Rita rita were generated for the first time. alphaA-crystallins, member of the alpha-crystallin family, which are molecular chaperons and play crucial role in maintaining lens transparency were identified by 1- and 2-D immunoblot analysis with anti-alphaA-crystallin antibody. Two protein bands of 19-20 kDa were identified as alphaA-crystallins on 1-D immunoblots and these bands separated into 10 discrete spots on 2-D immunoblot. However, anti-alphaB-crystallin and antiphospho-alphaB-crystallin antibodies were not able to detect any immunoreactive bands on 1- and 2-D immunoblots, indicating alphaB-crystallin was either absent or present in extremely low concentration in Rita rita lens. Thus, Rita rita alpha-crystallins are more like that of the catfish Clarias batrachus and the mammal kangaroo in its alphaA- and alphaB-crystallin content (contain low amount from 5-9% of alphaB-crystallin) and unlike the dogfish, zebrafish, human, bovine and mouse alpha-crystallins (contain higher amount of alphaB-crystallin from 25% in mouse and bovine to 85% in dogfish). Results of the present study can be the baseline information for stimulating further investigation on Rita rita lens crystallins for comparative lens proteomics. Comparing and contrasting the alpha-crystallins of the dogfish and Rita rita may provide valuable information on the functional attributes of alphaA- and alphaB-isoforms, as they are at the two extremes in terms of alphaA-and alphaB-crystallin content.

Evaluation of the best fit distribution for partial duration series of daily rainfall in Madinah, western Saudi Arabia

NASA Astrophysics Data System (ADS)

Alahmadi, F.; Rahman, N. A.; Abdulrazzak, M.

2014-09-01

Rainfall frequency analysis is an essential tool for the design of water related infrastructure. It can be used to predict future flood magnitudes for a given magnitude and frequency of extreme rainfall events. This study analyses the application of rainfall partial duration series (PDS) in the vast growing urban Madinah city located in the western part of Saudi Arabia. Different statistical distributions were applied (i.e. Normal, Log Normal, Extreme Value type I, Generalized Extreme Value, Pearson Type III, Log Pearson Type III) and their distribution parameters were estimated using L-moments methods. Also, different selection criteria models are applied, e.g. Akaike Information Criterion (AIC), Corrected Akaike Information Criterion (AICc), Bayesian Information Criterion (BIC) and Anderson-Darling Criterion (ADC). The analysis indicated the advantage of Generalized Extreme Value as the best fit statistical distribution for Madinah partial duration daily rainfall series. The outcome of such an evaluation can contribute toward better design criteria for flood management, especially flood protection measures.

Early Amyloidogenic Oligomerization Studied through Fluorescence Lifetime Correlation Spectroscopy

PubMed Central

Paredes, Jose M.; Casares, Salvador; Ruedas-Rama, Maria J.; Fernandez, Elena; Castello, Fabio; Varela, Lorena; Orte, Angel

2012-01-01

Amyloidogenic protein aggregation is a persistent biomedical problem. Despite active research in disease-related aggregation, the need for multidisciplinary approaches to the problem is evident. Recent advances in single-molecule fluorescence spectroscopy are valuable for examining heterogenic biomolecular systems. In this work, we have explored the initial stages of amyloidogenic aggregation by employing fluorescence lifetime correlation spectroscopy (FLCS), an advanced modification of conventional fluorescence correlation spectroscopy (FCS) that utilizes time-resolved information. FLCS provides size distributions and kinetics for the oligomer growth of the SH3 domain of α-spectrin, whose N47A mutant forms amyloid fibrils at pH 3.2 and 37 °C in the presence of salt. The combination of FCS with additional fluorescence lifetime information provides an exciting approach to focus on the initial aggregation stages, allowing a better understanding of the fibrillization process, by providing multidimensional information, valuable in combination with other conventional methodologies. PMID:22949804

Electro-triggering and electrochemical monitoring of dopamine exocytosis from a single cell by using ultrathin electrodes based on Au nanowires

NASA Astrophysics Data System (ADS)

Kang, Mijeong; Yoo, Seung Min; Gwak, Raekeun; Eom, Gayoung; Kim, Jihwan; Lee, Sang Yup; Kim, Bongsoo

2015-12-01

A sophisticated set of an Au nanowire (NW) stimulator-Au NW detector system is developed for electrical cell stimulation and electrochemical analysis of subsequent exocytosis with very high spatial resolution. Dopamine release from a rat pheochromocytoma cell is more stimulated by a more negative voltage pulse. This system could help to improve the therapeutic efficacy of electrotherapies by providing valuable information on their healing mechanism.A sophisticated set of an Au nanowire (NW) stimulator-Au NW detector system is developed for electrical cell stimulation and electrochemical analysis of subsequent exocytosis with very high spatial resolution. Dopamine release from a rat pheochromocytoma cell is more stimulated by a more negative voltage pulse. This system could help to improve the therapeutic efficacy of electrotherapies by providing valuable information on their healing mechanism. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr06021d

Drivers behind widespread informal payments in the Romanian public health care system: From tolerance to corruption to socio-economic and spatial patterns.

PubMed

Horodnic, Adrian V; Mazilu, Sorin; Oprea, Liviu

2018-03-15

In order to explain informal payments in public health care services in Romania, this paper evaluates the relationship between extra payments or valuable gifts (apart from official fees) and the level of tolerance to corruption, as well as the socio-economic and spatial patterns across those individuals offering informal payments. To evaluate this, a survey undertaken in 2013 is reported. Using logistic regression analysis, the findings are that patients with a high tolerance to corruption, high socio-economic risk (those divorced, separated, or with other form of marital status, and those not working), and located in rural or less affluent areas are more likely to offer (apart from official fees) extra payments or valuable gifts for health care services. The paper concludes by discussing the health policy implications. Copyright © 2018 John Wiley & Sons, Ltd.

Automated Weld Characterization Using the Thermoelectric Method

NASA Technical Reports Server (NTRS)

Fulton, J. P.; Wincheski, B.; Namkung, M.

1992-01-01

The effective assessment of the integrity of welds is a complicated NDE problem that continues to be a challenge. To be able to completely characterize a weld, detailed knowledge of its tensile strength, ductility, hardness, microstructure, macrostructure, and chemical composition is needed. NDE techniques which can provide information on any of these features are extremely important. In this paper, we examine a seldom used approach based on the thermoelectric (TE) effect for characterizing welds and their associated heat affected zone (HAZ). The thermoelectric method monitors the thermoelectric power which is sensitive to small changes in the kinetics of the conduction electrons near the Fermi surface that can be caused by changes in the local microstructure. The technique has been applied to metal sorting, quality testing, flaw detection, thickness gauging of layers, and microscopic structural analysis. To demonstrate the effectiveness of the technique for characterizing welds, a series of tungsten-inert-gas welded Inconel-718 samples were scanned with a computer controlled TE probe. The samples were then analyzed using a scanning electron microscope and Rockwell hardness tests to characterize the weld and the associated HAZ. We then correlated the results with the TE measurements to provide quantitative information on the size of the HAZ and the degree of hardness of the material in the weld region. This provides potentially valuable information on the strength and fatigue life of the weld. We begin the paper by providing a brief review of the TE technique and then highlight some of the factors that can effect the measurements. Next, we provide an overview of the experimental procedure and discuss the results. Finally, we summarize our findings and consider areas for future research.

Antiretroviral Therapy Program Expansion in Zambézia Province, Mozambique: Geospatial Mapping of Community-Based and Health Facility Data for Integrated Health Planning

PubMed Central

Moon, Troy D.; Ossemane, Ezequiel B.; Green, Ann F.; Ndatimana, Elisée; José, Eurico; Buehler, Charlotte P.; Wester, C. William; Vermund, Sten H.; Olupona, Omo

2014-01-01

Objective To generate maps reflecting the intersection of community-based Voluntary Counseling and Testing (VCT) delivery points with facility-based HIV program demographic information collected at the district level in three districts (Ile, Maganja da Costa and Chinde) of Zambézia Province, Mozambique; in order to guide planning decisions about antiretroviral therapy (ART) program expansion. Methods Program information was harvested from two separate open source databases maintained for community-based VCT and facility-based HIV care and treatment monitoring from October 2011 to September 2012. Maps were created using ArcGIS 10.1. Travel distance by foot within a 10 km radius is generally considered a tolerable distance in Mozambique for purposes of adherence and retention planning. Results Community-based VCT activities in each of three districts were clustered within geographic proximity to clinics providing ART, within communities with easier transportation access, and/or near the homes of VCT volunteers. Community HIV testing results yielded HIV seropositivity rates in some regions that were incongruent with the Ministry of Health’s estimates for the entire district (2–13% vs. 2% in Ile, 2–54% vs. 11.5% in Maganja da Costa, and 23–43% vs. 14.4% in Chinde). All 3 districts revealed gaps in regional disbursement of community-based VCT activities as well as access to clinics offering ART. Conclusions Use of geospatial mapping in the context of program planning and monitoring allowed for characterizing the location and size of each district’s HIV population. In extremely resource limited and logistically challenging settings, maps are valuable tools for informing evidence-based decisions in planning program expansion, including ART. PMID:25329169

Toxicity tests aiming to protect Brazilian aquatic systems: current status and implications for management.

PubMed

Martins, Samantha Eslava; Bianchini, Adalto

2011-07-01

The current status of toxicological tests performed with Brazilian native species was evaluated through a survey of the scientific data available in the literature. The information gathered was processed and an electronic toxicology database (http://www.inct-ta.furg.br/bd_toxicologico.php) was generated. This database provides valuable information for researchers to select sensitive and tolerant aquatic species to a large variety of aquatic pollutants. Furthermore, the toxicology database allows researchers to select species representative of an ecosystem of interest. Analysis of the toxicology database showed that ecotoxicological assays have significantly improved in Brazil over the last decade, in spite of the still relatively low number of tests performed and the restricted number of native species tested. This is because most of the research is developed in a few laboratories concentrated in certain regions of Brazil, especially in Southern and Southeast regions. Considering the extremely rich biodiversity and the large variety of aquatic ecosystems in Brazil, this finding points to the urgent need for the development of ecotoxicological studies with other groups of aquatic animals, such as insects, foraminifera, cnidarians, worms, amphibians, among others. This would help to derive more realistic water quality criteria (WQC) values, which would better protect the different aquatic ecosystems in Brazil. Finally, the toxicology database generated presents solid and science based information, which can encourage and drive the Environmental Regulatory Agencies in Brazil to derive WQC based on native species. In this context, the present paper discusses the historical evolution of ecotoxicological studies in Brazil, and how they have contributed to the improvement of the Brazilian Federal and Regional regulations for environment.

Mangrove species' responses to winter air temperature extremes in China

USGS Publications Warehouse

Chen, Luzhen; Wang, Wenqing; Li, Qingshun Q.; Zhang, Yihui; Yang, Shengchang; Osland, Michael J.; Huang, Jinliang; Peng, Congjiao

2017-01-01

The global distribution and diversity of mangrove forests is greatly influenced by the frequency and intensity of winter air temperature extremes. However, our understanding of how different mangrove species respond to winter temperature extremes has been lacking because extreme freezing and chilling events are, by definition, relatively uncommon and also difficult to replicate experimentally. In this study, we investigated species-specific variation in mangrove responses to winter temperature extremes in China. In 10 sites that span a latitudinal gradient, we quantified species-specific damage and recovery following a chilling event, for mangrove species within and outside of their natural range (i.e., native and non-native species, respectively). To characterize plant stress, we measured tree defoliation and chlorophyll fluorescence approximately one month following the chilling event. To quantify recovery, we measured chlorophyll fluorescence approximately nine months after the chilling event. Our results show high variation in the geographic- and species-specific responses of mangroves to winter temperature extremes. While many species were sensitive to the chilling temperatures (e.g., Bruguiera sexangula and species in the Sonneratia and Rhizophora genera), the temperatures during this event were not cold enough to affect certain species (e.g., Kandelia obovata, Aegiceras corniculatum, Avicennia marina, and Bruguiera gymnorrhiza). As expected, non-native species were less tolerant of winter temperature extremes than native species. Interestingly, tidal inundation modulated the effects of chilling. In comparison with other temperature-controlled mangrove range limits across the world, the mangrove range limit in China is unique due to the combination of the following three factors: (1) Mangrove species diversity is comparatively high; (2) winter air temperature extremes, rather than means, are particularly intense and play an important ecological role; and (3) due to afforestation and restoration efforts, several species of non-native mangroves have been introduced beyond their natural range limits. Hence, from a global perspective, mangroves in China provide valuable opportunities to advance understanding of the effects of freezing and chilling temperatures on mangroves. Within the context of climate change, our findings provide a foundation for better understanding and preparing for mangrove species-specific responses to future changes in the duration and intensity of winter temperature extremes.

A thermal-based remote sensing modeling system for estimating daily evapotranspiration from field to global scales

USDA-ARS?s Scientific Manuscript database

Thermal-infrared (TIR) remote sensing of land surface temperature (LST) provides valuable information for quantifying root-zone water availability, evapotranspiration (ET) and crop condition as well as providing useful information for constraining prognostic land surface models. This presentation d...

Six Wishes of a Public Service Librarian.

ERIC Educational Resources Information Center

Fescemyer, Kathy

2001-01-01

Suggests concepts related to information that would be valuable to library users, including the expenses related to information; unique qualities and characteristics of databases; limits of the Web; understanding differences between magazines and scholarly journals; search engine differences; and an appreciation for the amount and variety of…

Lessons from Personal Photography: The Digital Disruption of Selectivity and Reflection

ERIC Educational Resources Information Center

Fawns, Tim

2015-01-01

Recent technological, cultural and economic factors have shifted the balance between recalling and reconstructing internalised information and accessing externalised information. While digital artefacts constitute an enormous and valuable set of resources, human engagement and reflection are important to the meaningful synthesis and application of…

Technical summary : Travtek operational test evaluation : final reports

DOT National Transportation Integrated Search

2009-01-01

This guide is packed with useful information. It focuses on some of the less well-known safety messages the road offers you. It is designed to be kept in your glove compartment after it has been read so that you will have its valuable information at ...

76 FR 74776 - Forum-Trends in Extreme Winds, Waves, and Extratropical Storms Along the Coasts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... Winds, Waves, and Extratropical Storms Along the Coasts AGENCY: National Environmental Satellite, Data... information, please check the forum Web site at https://sites.google.com/a/noaa.gov/extreme-winds-waves.../noaa.gov/extreme-winds-waves-extratropical-storms/home . Topics To Be Addressed This forum will address...

Developing Effective Communications about Extreme Weather Risks.

NASA Astrophysics Data System (ADS)

Bruine de Bruin, W.

2014-12-01

Members of the general public often face complex decisions about the risks that they face, including those associated with extreme weather and climate change adaptation. Scientific experts may be asked to develop communications with the goal of improving people's understanding of weather and climate risks, and informing people's decisions about how to protect against these risks. Unfortunately, scientific experts' communication efforts may fail if they lack information about what people need or want to know to make more informed decisions or what wording people prefer use to describe relevant concepts. This presentation provides general principles for developing effective risk communication materials that aim for widespread dissemination, such as brochures and websites. After a brief review of the social science evidence on how to design effective risk communication materials, examples will focus on communications about extreme weather events and climate change. Specifically, data will be presented from ongoing projects on flood risk perception, public preparedness for heat waves, and public perceptions of climate change. The presentation will end with specific recommendations about how to improve recipients' understanding about risks and inform decisions. These recommendations should be useful to scientific experts who aim to communicate about extreme weather, climate change, or other risks.

Regional trends in short-duration precipitation extremes: a flexible multivariate monotone quantile regression approach

NASA Astrophysics Data System (ADS)

Cannon, Alex

2017-04-01

Estimating historical trends in short-duration rainfall extremes at regional and local scales is challenging due to low signal-to-noise ratios and the limited availability of homogenized observational data. In addition to being of scientific interest, trends in rainfall extremes are of practical importance, as their presence calls into question the stationarity assumptions that underpin traditional engineering and infrastructure design practice. Even with these fundamental challenges, increasingly complex questions are being asked about time series of extremes. For instance, users may not only want to know whether or not rainfall extremes have changed over time, they may also want information on the modulation of trends by large-scale climate modes or on the nonstationarity of trends (e.g., identifying hiatus periods or periods of accelerating positive trends). Efforts have thus been devoted to the development and application of more robust and powerful statistical estimators for regional and local scale trends. While a standard nonparametric method like the regional Mann-Kendall test, which tests for the presence of monotonic trends (i.e., strictly non-decreasing or non-increasing changes), makes fewer assumptions than parametric methods and pools information from stations within a region, it is not designed to visualize detected trends, include information from covariates, or answer questions about the rate of change in trends. As a remedy, monotone quantile regression (MQR) has been developed as a nonparametric alternative that can be used to estimate a common monotonic trend in extremes at multiple stations. Quantile regression makes efficient use of data by directly estimating conditional quantiles based on information from all rainfall data in a region, i.e., without having to precompute the sample quantiles. The MQR method is also flexible and can be used to visualize and analyze the nonlinearity of the detected trend. However, it is fundamentally a univariate technique, and cannot incorporate information from additional covariates, for example ENSO state or physiographic controls on extreme rainfall within a region. Here, the univariate MQR model is extended to allow the use of multiple covariates. Multivariate monotone quantile regression (MMQR) is based on a single hidden-layer feedforward network with the quantile regression error function and partial monotonicity constraints. The MMQR model is demonstrated via Monte Carlo simulations and the estimation and visualization of regional trends in moderate rainfall extremes based on homogenized sub-daily precipitation data at stations in Canada.

A Lessons Learned Knowledge Warehouse to Support the Army Knowledge Management Command-Centric

DTIC Science & Technology

2004-03-01

Warehouse to Support the Army Knowledge Management Command-Centric increase the quality and availability of information in context ( knowledge ) to the... information , geographical information , knowledge base, Intelligence data (HUMINT, SIGINT, etc.); and • • Human Computer Interaction (HCI): allows...the Data Fusion Process from the HCI point of view? Can the LL Knowledge Base provide any valuable information to achieve better estimates of the

How Source Information Shapes Lay Interpretations of Science Conflicts: Interplay between Sourcing, Conflict Explanation, Source Evaluation, and Claim Evaluation

ERIC Educational Resources Information Center

Thomm, Eva; Bromme, Rainer

2016-01-01

When laypeople read controversial scientific information in order to make a personally relevant decision, information on the source is a valuable resource with which to evaluate multiple, competing claims. Due to their bounded understanding, laypeople rely on the expertise of others and need to identify whether sources are credible. The present…

The Invisible Web: Uncovering Information Sources Search Engines Can't See.

ERIC Educational Resources Information Center

Sherman, Chris; Price, Gary

This book takes a detailed look at the nature and extent of the Invisible Web, and offers pathfinders for accessing the valuable information it contains. It is designed to fit the needs of both novice and advanced Web searchers. Chapter One traces the development of the Internet and many of the early tools used to locate and share information via…

The Trade-Off: Consumer Privacy for Technology Products and Services

ERIC Educational Resources Information Center

Scibelli, David B.

2013-01-01

With the Internet advancements of information systems and social media channels, consumer data has become a valuable source for companies and social networking communities. These Internet businesses are allowed to use and share their customers' information, with minimal regulatory intervention other than in health and financial areas. This…

Numbers Are Not Enough. Why e-Learning Analytics Failed to Inform an Institutional Strategic Plan

ERIC Educational Resources Information Center

Macfadyen, Leah P.; Dawson, Shane

2012-01-01

Learning analytics offers higher education valuable insights that can inform strategic decision-making regarding resource allocation for educational excellence. Research demonstrates that learning management systems (LMSs) can increase student sense of community, support learning communities and enhance student engagement and success, and LMSs…

An energy balance approach for mapping crop waterstress and yield impacts over the Czech Republic

USDA-ARS?s Scientific Manuscript database

There is a growing demand for timely, spatially distributed information regarding crop condition and water use to inform agricultural decision making and yield forecasting efforts. Remote sensing of land-surface temperature has proven valuable for mapping evapotranspiration (ET) and crop stress from...

Key Facts about Higher Education in Washington: 2009-10

ERIC Educational Resources Information Center

Washington Higher Education Coordinating Board, 2010

2010-01-01

First published in 2002, "Key Facts about Higher Education in Washington" provides valuable information on the ways higher education serves the state and its people. The most current data and information available is presented throughout this report to highlight the "Key Facts" about Washington's postsecondary institutions,…

Land Use Planning Exercise Using Geographic Information Systems and Digital Soil Surveys

ERIC Educational Resources Information Center

Stout, Heidi M.; Lee, Brad D.

2004-01-01

Geographic information system (GIS) technology has become a valuable tool for environmental science professionals. By incorporating GIS into college-level course curricula, agricultural students become better qualified for employment opportunities. We have developed a case study-based laboratory exercise that introduces students to GIS and the…

Creating Better Library Information Systems: The Road to FRBR-Land

ERIC Educational Resources Information Center

Mercun, Tanja; Švab, Katarina; Harej, Viktor; Žumer, Maja

2013-01-01

Introduction: To provide valuable services in the future, libraries will need to create better information systems and set up an infrastructure more in line with the current technologies. The "Functional Requirements for Bibliographic Records" conceptual model provides a basis for this transformation, but there are still a number of…

IsoBank – Stable isotope ecology in the age of ‘Big Data’

USDA-ARS?s Scientific Manuscript database

Stable isotopes ratios provide valuable information to fish biologists working in a diverse range of fields: e.g. ecologists, population biologists and fishery managers. Ecologists take advantage of stable isotope ratios to provide information on the diet and migration history of consumers or when a...

Synthesis Can Take Many Forms

ERIC Educational Resources Information Center

Darrow, Rob

2005-01-01

Synthesis can take many forms at the high school level and from a Big6 perspective. Synthesis means purposeful, valuable and interesting assignments. It is very important for a classroom teacher to recognize that students can synthesize information several times during a project and that there are many different ways to present information.

The International Performance of the South African Academic Institutions: A Citation Assessment

ERIC Educational Resources Information Center

Pouris, Anastassios

2007-01-01

This article reports the results of an investigation to identify the disciplinary strengths and the international standing of the higher education institutions in South Africa. Even though comparative assessments provide valuable information for research administrations, researchers and students such information is not available in South Africa…

Decoding tree DNA

Treesearch

M. Thompson Conkle

1986-01-01

Check the laboratory reports after your next physical. You'll find information on a number of biochemical processes. Procedures like those used in the medical sciences are yielding valuable information about genetic differences among trees and tree pests. New procedures that provide ways to isolate and move genes are advancing progress in tree improvement. These...

76 FR 42471 - Premerger Notification; Reporting and Waiting Period Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... reach those Confidential Information Memoranda, as stated in Comment 1, received by ``any employee... of seeking an engagement.'' These materials are sometimes also known informally as ``bankers' books... as valuable to staff. Whether developed by a third party for the purpose of seeking an engagement or...

Quantitative Analysis of Non-Financial Motivators and Job Satisfaction of Information Technology Professionals

ERIC Educational Resources Information Center

Mieszczak, Gina L.

2013-01-01

Organizations depend extensively on Information Technology professionals to drive and deliver technology solutions quickly, efficiently, and effectively to achieve business goals and profitability. It has been demonstrated that professionals with experience specific to the company are valuable assets, and their departure puts technology projects…

A Cross-Cultural Journey into Literacy Research

ERIC Educational Resources Information Center

Tour, Ekaterina

2012-01-01

A significant body of literacy and language research over the last two decades has been informed by a sociocultural perspective and an associated qualitative design, which are often seen as valuable and appropriate for researching literacy. As an emergent researcher, whose understanding of language education was mostly informed by individualistic…

The Complete Learning Disabilities Directory. 2017 Edition

ERIC Educational Resources Information Center

Grey House Publishing, 2016

2016-01-01

Published for over a decade, this directory continues to be a successful, sought-after resource, providing valuable information to professionals, families, and individuals in the learning disabilities community. Supported by the National Center for Learning Disabilities, this 2017 edition brings together the most up-to-date information on LD…

Mining Social Media Data for Understanding Students' Learning Experiences

ERIC Educational Resources Information Center

Chen, Xin; Vorvoreanu, Mihaela; Madhavan, Krishna

2014-01-01

Students' informal conversations on social media (e.g., Twitter, Facebook) shed light into their educational experiences--opinions, feelings, and concerns about the learning process. Data from such uninstrumented environments can provide valuable knowledge to inform student learning. Analyzing such data, however, can be challenging. The complexity…

Social Argumentation in Online Synchronous Communication

ERIC Educational Resources Information Center

Alagoz, Esra

2013-01-01

The ability to argue well is a valuable skill for students in both formal and informal learning environments. While many studies have explored the argumentative practices in formal environments and some researchers have developed tools to enhance the argumentative skills, the social argumentation that is occurring in informal spaces has yet to be…

Free Recall Test Experience Potentiates Strategy-Driven Effects of Value on Memory

ERIC Educational Resources Information Center

Cohen, Michael S.; Rissman, Jesse; Hovhannisyan, Mariam; Castel, Alan D.; Knowlton, Barbara J.

2017-01-01

People tend to show better memory for information that is deemed valuable or important. By one mechanism, individuals selectively engage deeper, semantic encoding strategies for high value items (Cohen, Rissman, Suthana, Castel, & Knowlton, 2014). By another mechanism, information paired with value or reward is automatically strengthened in…

The Complete Learning Disabilities Directory. 2011 Edition

ERIC Educational Resources Information Center

Grey House Publishing, 2010

2010-01-01

Published for over a decade, this directory continues to be a successful, sought-after resource, providing valuable information to professionals, families, and individuals in the learning disabilities community. Supported by the National Center for Learning Disabilities, this 2011 edition brings together the most up-to-date information on LD…

Mathematics Framework for the 2011 National Assessment of Educational Progress

ERIC Educational Resources Information Center

National Assessment Governing Board, 2010

2010-01-01

Since 1973, the National Assessment of Educational Progress (NAEP) has gathered information about student achievement in mathematics. Results of these periodic assessments, produced in print and web-based formats, provide valuable information to a wide variety of audiences. The NAEP Assessment in mathematics has two components that differ in…

The Marketing of Information Analysis Center Products and Services.

ERIC Educational Resources Information Center

Veazie, Walter H., Jr.; Connolly, Thomas F.

Information analysis centers (IACs) represent a valuable national resource which has not been fully utilized, often because their products and services are not widely known. Recent Government economy measures demand consideration of increased marketability of these products and services and the institution of service charges as a possible source…

Using Community Assessments to Improve 4-H Youth Development Programming Efforts

ERIC Educational Resources Information Center

Teuteberg, Dan; Cummins, Melissa M.

2017-01-01

Understanding resources available in a community is essential before any 4-H youth development professional can begin addressing local needs. Conducting a community assessment generates valuable information about the unique components and resources of a specific community. This information then provides a foundation for identifying specific…

Ownership of Traditional Information: Moral and Legal Obligations to Compensate for Taking.

ERIC Educational Resources Information Center

McNeil, Richard J.; McNeil, Michael J.

1989-01-01

Argues that "indigenous" people transferring cultural information to other, more "developed" people should have legal protection from unfair transactions. Presents ethical and legal bases for such protection. Examples involve the knowledge of rain-forest tribes that has been used to produce valuable pharmaceutical products from…

EGFR gene overexpression retained in an invasive xenograft model by solid orthotopic transplantation of human glioblastoma multiforme into nude mice.

PubMed

Yi, Diao; Hua, Tian Xin; Lin, Huang Yan

2011-03-01

Orthotopic xenograft animal model from human glioblastoma multiforme (GBM) cell lines often do not recapitulate an extremely important aspect of invasive growth and epidermal growth factor receptor (EGFR) gene overexpression of human GBM. We developed an orthotopic xenograft model by solid transplantation of human GBM into the brain of nude mouse. The orthotopic xenografts sharing the same histopathological features with their original human GBMs were highly invasive and retained the overexpression of EGFR gene. The murine orthotopic GBM models constitute a valuable in vivo system for preclinical studies to test novel therapies for human GBM.

Shock Waves in Supernova Ejecta

NASA Astrophysics Data System (ADS)

Raymond, J. C.

2018-02-01

Astrophysical shock waves are a major mechanism for dissipating energy, and by heating and ionizing the gas they produce emission spectra that provide valuable diagnostics for the shock parameters, for the physics of collisionless shocks, and for the composition of the shocked material. Shocks in SN ejecta in which H and He have been burned to heavier elements behave differently than shocks in ordinary astrophysical gas because of their very large radiative cooling rates. In particular, extreme departures from thermal equilibrium among ions and electrons and from ionization equilibrium may arise. This paper discusses the consequences of the enhanced metal abundances for the structure and emission spectra of those shocks.

Dose mapping using MCNP code and experiment for SVST-Co-60/B irradiator in Vietnam.

PubMed

Tran, Van Hung; Tran, Khac An

2010-06-01

By using MCNP code and ethanol-chlorobenzene (ECB) dosimeters the simulations and measurements of absorbed dose distribution in a tote-box of the Cobalt-60 irradiator, SVST-Co60/B at VINAGAMMA have been done. Based on the results Dose Uniformity Ratios (DUR), positions and values of minimum and maximum dose extremes in a tote-box, and efficiency of the irradiator for the different dummy densities have been gained. There is a good agreement between simulation and experimental results in comparison and they have valuable meanings for operation of the irradiator. Copyright 2010 Elsevier Ltd. All rights reserved.

Analysis of the quality of image data acquired by the LANDSAT-4 thematic mapper and multispectral scanners. [Central Valley, California

NASA Technical Reports Server (NTRS)

Colwell, R. N. (Principal Investigator)

1983-01-01

Image products and numeric data were extracted from both TM and MSS data in an effort to evaluate the quality of these data for interpreting major agricultural resources and conditions in California's Central Valley. The utility of TM data appears excellent for meeting most of the inventory objectives of the agricultural resource specialist. These data should be extremely valuable for crop type and area proportion estimation, for updating agricultural land use survey maps at 1:24,000-scale and smaller, for field boundary definition, and for determining the size and location of individual farmsteads.

Lunar Simulation in the Lunar Dust Adhesion Bell Jar

NASA Technical Reports Server (NTRS)

Gaier, James R.; Sechkar, Edward A.

2007-01-01

The Lunar Dust Adhesion Bell Jar has been assembled at the NASA Glenn Research Center to provide a high fidelity lunar simulation facility to test the interactions of lunar dust and lunar dust simulant with candidate aerospace materials and coatings. It has a sophisticated design which enables it to treat dust in a way that will remove adsorbed gases and create a chemically reactive surface. It can simulate the vacuum, thermal, and radiation environments of the Moon, including proximate areas of illuminated heat and extremely cold shadow. It is expected to be a valuable tool in the development of dust repellant and cleaning technologies for lunar surface systems.

Communication path for extreme environments

NASA Technical Reports Server (NTRS)

Jorgensen, Charles C. (Inventor); Betts, Bradley J. (Inventor)

2010-01-01

Methods and systems for using one or more radio frequency identification devices (RFIDs), or other suitable signal transmitters and/or receivers, to provide a sensor information communication path, to provide location and/or spatial orientation information for an emergency service worker (ESW), to provide an ESW escape route, to indicate a direction from an ESW to an ES appliance, to provide updated information on a region or structure that presents an extreme environment (fire, hazardous fluid leak, underwater, nuclear, etc.) in which an ESW works, and to provide accumulated thermal load or thermal breakdown information on one or more locations in the region.

Representing Extremes in Agricultural Models

NASA Technical Reports Server (NTRS)

Ruane, Alex

2015-01-01

AgMIP and related projects are conducting several activities to understand and improve crop model response to extreme events. This involves crop model studies as well as the generation of climate datasets and scenarios more capable of capturing extremes. Models are typically less responsive to extreme events than we observe, and miss several forms of extreme events. Models also can capture interactive effects between climate change and climate extremes. Additional work is needed to understand response of markets and economic systems to food shocks. AgMIP is planning a Coordinated Global and Regional Assessment of Climate Change Impacts on Agricultural Production and Food Security with an aim to inform the IPCC Sixth Assessment Report.

Development of the Electron Drift Instrument (EDI) for Cluster

NASA Technical Reports Server (NTRS)

Quinn, Jack; Christensen, John L. (Technical Monitor)

2001-01-01

The Electron Drift Instrument (EDI) is a new technique for measuring electric fields in space by detecting the effect on weak beams of test electrons. This U.S. portions of the technique, flight hardware, and flight software were developed for the Cluster mission under this contract. Dr. Goetz Paschmann of the Max Planck Institute in Garching, Germany, was the Principle Investigator for Cluster EDI. Hardware for Cluster was developed in the U.S. at the University of New Hampshire, Lockheed Palo Alto Research Laboratory, and University of California, San Diego. The Cluster satellites carrying the original EDI instruments were lost in the catastrophic launch failure of first flight of the Arianne-V rocket in 1996. Following that loss, NASA and ESA approved a rebuild of the Cluster mission, for which all four satellites were successfully launched in the Summer of 2000. Limited operations of EDI were also obtained on the Equator-S satellite, which was launched in December, 1997. A satellite failure caused a loss of the Equator-S mission after only 5 months, but these operations were extremely valuable in learning about the characteristics and operations of the complex EDI instrument. The Cluster mission, satellites, and instruments underwent an extensive on-orbit commissioning phase in the Fall of 2000, carrying over through January 2001. During this period all elements of the instruments were checked and careful measurements of inter-experiments interferences were made. EDI is currently working exceptionally well in orbit. Initial results verify that all aspects of the instrument are working as planned, and returning highly valuable scientific information. The first two papers describing EDI on-orbit results have been submitted for publication in April, 2001. The principles of the EDI technique, and its implementation on Cluster are described in two papers by Paschmann et al., attached as Appendices A and B. The EDI presentation at the formal Cluster Commissioning Review, held at ESA Headquarters in Paris, is attached as Appendix C.

A cricket Gene Index: a genomic resource for studying neurobiology, speciation, and molecular evolution

PubMed Central

Danley, Patrick D; Mullen, Sean P; Liu, Fenglong; Nene, Vishvanath; Quackenbush, John; Shaw, Kerry L

2007-01-01

Background As the developmental costs of genomic tools decline, genomic approaches to non-model systems are becoming more feasible. Many of these systems may lack advanced genetic tools but are extremely valuable models in other biological fields. Here we report the development of expressed sequence tags (EST's) in an orthopteroid insect, a model for the study of neurobiology, speciation, and evolution. Results We report the sequencing of 14,502 EST's from clones derived from a nerve cord cDNA library, and the subsequent construction of a Gene Index from these sequences, from the Hawaiian trigonidiine cricket Laupala kohalensis. The Gene Index contains 8607 unique sequences comprised of 2575 tentative consensus (TC) sequences and 6032 singletons. For each of the unique sequences, an attempt was made to assign a provisional annotation and to categorize its function using a Gene Ontology-based classification through a sequence-based comparison to known proteins. In addition, a set of unique 70 base pair oligomers that can be used for DNA microarrays was developed. All Gene Index information is posted at the DFCI Gene Indices web page Conclusion Orthopterans are models used to understand the neurophysiological basis of complex motor patterns such as flight and stridulation. The sequences presented in the cricket Gene Index will provide neurophysiologists with many genetic tools that have been largely absent in this field. The cricket Gene Index is one of only two gene indices to be developed in an evolutionary model system. Species within the genus Laupala have speciated recently, rapidly, and extensively. Therefore, the genes identified in the cricket Gene Index can be used to study the genomics of speciation. Furthermore, this gene index represents a significant EST resources for basal insects. As such, this resource is a valuable comparative tool for the understanding of invertebrate molecular evolution. The sequences presented here will provide much needed genomic resources for three distinct but overlapping fields of inquiry: neurobiology, speciation, and molecular evolution. PMID:17459168

Rare Diseases on the Internet: An Assessment of the Quality of Online Information.

PubMed

Pauer, Frédéric; Litzkendorf, Svenja; Göbel, Jens; Storf, Holger; Zeidler, Jan; Graf von der Schulenburg, Johann-Matthias

2017-01-18

The importance of the Internet as a medium for publishing and sharing health and medical information has increased considerably during the last decade. Nonetheless, comprehensive knowledge and information are scarce and difficult to find, especially for rare diseases. Additionally, the quality of health or medical information about rare diseases is frequently difficult to assess for the patients and their family members. The aim of this study is to assess the quality of information on the Internet about rare diseases. Additionally, the study aims to evaluate if the quality of information on rare diseases varies between different information supplier categories. A total of 13 quality criteria for websites providing medical information about rare diseases were transferred to a self-disclosure questionnaire. Identified providers of information on the Internet about rare diseases were invited to fill out the questionnaire. The questionnaire contained questions about the information provider in general (eg, supplier category, information category, language, use of quality certificates, and target group) and about quality aspects that reflect the 13 quality criteria. Differences in subgroup analyses were performed using t tests. We identified 693 websites containing information about rare diseases. A total of 123 questionnaires (17.7%) were completely filled out by the information suppliers. For the remaining identified suppliers (570/693, 82.3%), the questionnaires were filled out by the authors based on the information available on their website. In many cases, the quality of websites was proportionally low. Furthermore, subgroup analysis showed no statistically significant differences between the quality of information provided by support group/patient organization compared to medical institution (P=.19). The quality of information by individuals (patient/relative) was significantly lower compared to information provided by support group/patient organization (P=.001), medical institution (P=.009), and other associations and sponsoring bodies (P=.001) as well. Overall, the quality of information on the Internet about rare diseases is low. Quality certificates are rarely used and important quality criteria are often not fulfilled completely. Additionally, some information categories are underrepresented (eg, information about psychosocial counseling, social-legal advice, and family planning). Nevertheless, due to the high amount of information provided by support groups, this study shows that these are extremely valuable sources of information for patients suffering from a rare disease and their relatives. ©Frédéric Pauer, Svenja Litzkendorf, Jens Göbel, Holger Storf, Jan Zeidler, Johann-Matthias Graf von der Schulenburg. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 18.01.2017.

Combining Radar and Daily Precipitation Data to Estimate Meaningful Sub-daily Precipitation Extremes

NASA Astrophysics Data System (ADS)

Pegram, G. G. S.; Bardossy, A.

2016-12-01

Short duration extreme rainfalls are important for design. The purpose of this presentation is not to improve the day by day estimation of precipitation, but to obtain reasonable statistics for the subdaily extremes at gauge locations. We are interested specifically in daily and sub-daily extreme values of precipitation at gauge locations. We do not employ the common procedure of using time series of control station to determine the missing data values in a target. We are interested in individual rare events, not sequences. The idea is to use radar to disaggregate daily totals to sub-daily amounts. In South Arica, an S-band radar operated relatively continuously at Bethlehem from 1998 to 2003, whose scan at 1.5 km above ground [CAPPI] overlapped a dense (10 km spacing) set of 45 pluviometers recording in the same 6-year period. Using this valuable set of data, we are only interested in rare extremes, therefore small to medium values of rainfall depth were neglected, leaving 12 days of ranked daily maxima in each set per year, whose sum typically comprised about 50% of each annual rainfall total. The method presented here uses radar for disaggregating daily gauge totals in subdaily intervals down to 15 minutes in order to extract the maxima of sub-hourly through to daily rainfall at each of 37 selected radar pixels [1 km square in plan] which contained one of the 45 pluviometers not masked out by the radar foot-print. The pluviometer data were aggregated to daily totals, to act as if they were daily read gauges; their only other task was to help in the cross-validation exercise. The extrema were obtained as quantiles by ordering the 12 daily maxima of each interval per year. The unusual and novel goal was not to obtain the reproduction of the precipitation matching in space and time, but to obtain frequency distributions of the gauge and radar extremes, by matching their ranks, which we found to be stable and meaningful in cross-validation tests. We provide and compare a range of different methodologies to enable reasonable estimation of subdaily extremes using radar and daily precipitation observations.

Manipulating the fidelity of lower extremity visual feedback to identify obstacle negotiation strategies in immersive virtual reality.

PubMed

Kim, Aram; Zhou, Zixuan; Kretch, Kari S; Finley, James M

2017-07-01

The ability to successfully navigate obstacles in our environment requires integration of visual information about the environment with estimates of our body's state. Previous studies have used partial occlusion of the visual field to explore how information about the body and impending obstacles are integrated to mediate a successful clearance strategy. However, because these manipulations often remove information about both the body and obstacle, it remains to be seen how information about the lower extremities alone is utilized during obstacle crossing. Here, we used an immersive virtual reality (VR) interface to explore how visual feedback of the lower extremities influences obstacle crossing performance. Participants wore a head-mounted display while walking on treadmill and were instructed to step over obstacles in a virtual corridor in four different feedback trials. The trials involved: (1) No visual feedback of the lower extremities, (2) an endpoint-only model, (3) a link-segment model, and (4) a volumetric multi-segment model. We found that the volumetric model improved success rate, placed their trailing foot before crossing and leading foot after crossing more consistently, and placed their leading foot closer to the obstacle after crossing compared to no model. This knowledge is critical for the design of obstacle negotiation tasks in immersive virtual environments as it may provide information about the fidelity necessary to reproduce ecologically valid practice environments.

Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding.

PubMed

Andrew, Audra L; Card, Daren C; Ruggiero, Robert P; Schield, Drew R; Adams, Richard H; Pollock, David D; Secor, Stephen M; Castoe, Todd A

2015-05-01

Snakes provide a unique and valuable model system for studying the extremes of physiological remodeling because of the ability of some species to rapidly upregulate organ form and function upon feeding. The predominant model species used to study such extreme responses has been the Burmese python because of the extreme nature of postfeeding response in this species. We analyzed the Burmese python intestine across a time series, before, during, and after feeding to understand the patterns and timing of changes in gene expression and their relationship to changes in intestinal form and function upon feeding. Our results indicate that >2,000 genes show significant changes in expression in the small intestine following feeding, including genes involved in intestinal morphology and function (e.g., hydrolases, microvillus proteins, trafficking and transport proteins), as well as genes involved in cell division and apoptosis. Extensive changes in gene expression occur surprisingly rapidly, within the first 6 h of feeding, coincide with changes in intestinal morphology, and effectively return to prefeeding levels within 10 days. Collectively, our results provide an unprecedented portrait of parallel changes in gene expression and intestinal morphology and physiology on a scale that is extreme both in the magnitude of changes, as well as in the incredibly short time frame of these changes, with up- and downregulation of expression and function occurring in the span of 10 days. Our results also identify conserved vertebrate signaling pathways that modulate these responses, which may suggest pathways for therapeutic modulation of intestinal function in humans. Copyright © 2015 the American Physiological Society.

Total and Lower Extremity Lean Mass Percentage Positively Correlates With Jump Performance.

PubMed

Stephenson, Mitchell L; Smith, Derek T; Heinbaugh, Erika M; Moynes, Rebecca C; Rockey, Shawn S; Thomas, Joi J; Dai, Boyi

2015-08-01

Strength and power have been identified as valuable components in both athletic performance and daily function. A major component of strength and power is the muscle mass, which can be assessed with dual-energy x-ray absorptiometry (DXA). The primary purpose of this study was to quantify the relationship between total body lean mass percentage (TBLM%) and lower extremity lean mass percentage (LELM%) and lower extremity force/power production during a countermovement jump (CMJ) in a general population. Researchers performed a DXA analysis on 40 younger participants aged 18-35 years, 28 middle-aged participants aged 36-55 years, and 34 older participants aged 56-75 years. Participants performed 3 CMJ on force platforms. Correlations revealed significant and strong relationships between TBLM% and LELM% compared with CMJ normalized peak vertical ground reaction force (p < 0.001, r = 0.59), normalized peak vertical power (p < 0.001, r = 0.73), and jump height (p < 0.001, r = 0.74) for the combined age groups. Most relationships were also strong within each age group, with some relationships being relatively weaker in the middle-aged and older groups. Minimal difference was found between correlation coefficients of TBLM% and LELM%. Coefficients of determination were all below 0.6 for the combined group, indicating that between-participant variability in CMJ measures cannot be completely explained by lean mass percentages. The findings have implications in including DXA-assessed lean mass percentage as a component for evaluating lower extremity strength and power. A paired DXA analysis and CMJ jump test may be useful for identifying neuromuscular deficits that limit performance.

Effects of power-line construction on wetland vegetation in Massachusetts, USA

NASA Astrophysics Data System (ADS)

Nickerson, Norton H.; Dobberteen, Ross A.; Jarman, Nancy M.

1989-07-01

Utility rights-of-way corridors through wetland areas generate long-term impacts from construction activities to these valuable ecosystems. Changes to and recovery of the vegetation communities of a cattail marsh, wooded swamp, and shrub/bog wetland were documented through measurements made each growing season for two years prior, five years following, and again on the tenth year after construction of a 345-kV transmission line. While both the cattail marsh and wooded swamp recovered within a few years, measures of plant community composition in the shrub/bog wetland were still lower, compared to controls, after ten years. Long-term investigations such as the one reported here help decrease uncertainty and provide valuable information for future decision making regarding construction of power utility lines through valuable and dwindling wetland resources.

Transcriptomic analysis of Crassostrea sikamea × Crassostrea angulata hybrids in response to low salinity stress.

PubMed

Yan, Lulu; Su, Jiaqi; Wang, Zhaoping; Yan, Xiwu; Yu, Ruihai; Ma, Peizhen; Li, Yangchun; Du, Junpeng

2017-01-01

Hybrid oysters often show heterosis in growth rate, weight, survival and adaptability to extremes of salinity. Oysters have also been used as model organisms to study the evolution of host-defense system. To gain comprehensive knowledge about various physiological processes in hybrid oysters under low salinity stress, we performed transcriptomic analysis of gill tissue of Crassostrea sikamea ♀ × Crassostrea angulata♂ hybrid using the deep-sequencing platform Illumina HiSeq. We exploited the high-throughput technique to delineate differentially expressed genes (DEGs) in oysters maintained in hypotonic conditions. A total of 199,391 high quality unigenes, with average length of 644 bp, were generated. Of these 35 and 31 genes showed up- and down-regulation, respectively. Functional categorization and pathway analysis of these DEGs revealed enrichment for immune mechanism, apoptosis, energy metabolism and osmoregulation under low salinity stress. The expression patterns of 41 DEGs in hybrids and their parental species were further analyzed by quantitative real-time PCR (qRT-PCR). This study will serve as a platform for subsequent gene expression analysis regarding environmental stress. Our findings will also provide valuable information about gene expression to better understand the immune mechanism, apoptosis, energy metabolism and osmoregulation in hybrid oysters under low salinity stress.

The effect of genome-wide association scan quality control on imputation outcome for common variants.

PubMed

Southam, Lorraine; Panoutsopoulou, Kalliope; Rayner, N William; Chapman, Kay; Durrant, Caroline; Ferreira, Teresa; Arden, Nigel; Carr, Andrew; Deloukas, Panos; Doherty, Michael; Loughlin, John; McCaskie, Andrew; Ollier, William E R; Ralston, Stuart; Spector, Timothy D; Valdes, Ana M; Wallis, Gillian A; Wilkinson, J Mark; Marchini, Jonathan; Zeggini, Eleftheria

2011-05-01

Imputation is an extremely valuable tool in conducting and synthesising genome-wide association studies (GWASs). Directly typed SNP quality control (QC) is thought to affect imputation quality. It is, therefore, common practise to use quality-controlled (QCed) data as an input for imputing genotypes. This study aims to determine the effect of commonly applied QC steps on imputation outcomes. We performed several iterations of imputing SNPs across chromosome 22 in a dataset consisting of 3177 samples with Illumina 610 k (Illumina, San Diego, CA, USA) GWAS data, applying different QC steps each time. The imputed genotypes were compared with the directly typed genotypes. In addition, we investigated the correlation between alternatively QCed data. We also applied a series of post-imputation QC steps balancing elimination of poorly imputed SNPs and information loss. We found that the difference between the unQCed data and the fully QCed data on imputation outcome was minimal. Our study shows that imputation of common variants is generally very accurate and robust to GWAS QC, which is not a major factor affecting imputation outcome. A minority of common-frequency SNPs with particular properties cannot be accurately imputed regardless of QC stringency. These findings may not generalise to the imputation of low frequency and rare variants.

Trail impacts in Sagarmatha (Mt. Everest) National Park, Nepal: a logistic regression analysis.

PubMed

Nepal, S K

2003-09-01

A trail study was conducted in the Sagarmatha (Mt. Everest) National Park, Nepal, during 1997-1998. Based on that study, this paper examines the spatial variability of trail conditions and analyzes factors that influence trail conditions. Logistic regression (multinomial logit model) is applied to examine the influence of use and environmental factors on trail conditions. The assessment of trail conditions is based on a four-class rating system: (class I, very little damaged; class II, moderately damaged, class III, heavily damaged; and class IV, severely damaged). Wald statistics and a model classification table have been used for data interpretation. Results indicate that altitude, trail gradient, hazard potential, and vegetation type are positively associated with trail condition. Trails are more degraded at higher altitude, on steep gradients, in areas with natural hazard potential, and within shrub/grassland zones. Strong correlations between high levels of trail degradation and higher frequencies of visitors and lodges were found. A detailed analysis of environmental and use factors could provide valuable information to park managers in their decisions about trail design, layout and maintenance, and efficient and effective visitor management strategies. Comparable studies on high alpine environments are needed to predict precisely the effects of topographic and climatic extremes. More refined approaches and experimental methods are necessary to control the effects of environmental factors.

Integrated ecological risk assessment of pesticides in tropical ecosystems: a case study with carbofuran in Brazil.

PubMed

Chelinho, Sónia; Lopes, Isabel; Natal-da-Luz, Tiago; Domene, Xaxier; Nunes, Maria Edna Tenorio; Espíndola, Evaldo L G; Ribeiro, Rui; Sousa, Jose P

2012-02-01

The aim of the present study is to contribute an ecologically relevant assessment of the ecotoxicological effects of pesticide applications in agricultural areas in the tropics, using an integrated approach with information gathered from soil and aquatic compartments. Carbofuran, an insecticide/nematicide used widely on sugarcane crops, was selected as a model substance. To evaluate the toxic effects of pesticide spraying for soil biota, as well as the potential indirect effects on aquatic biota resulting from surface runoff and/or leaching, field and laboratory (using a cost-effective simulator of pesticide applications) trials were performed. Standard ecotoxicological tests were performed with soil (Eisenia andrei, Folsomia candida, and Enchytraeus crypticus) and aquatic (Ceriodaphnia silvestrii) organisms, using serial dilutions of soil, eluate, leachate, and runoff samples. Among soil organisms, sensitivity was found to be E. crypticus < E. andrei < F. candida. Among the aqueous extracts, mortality of C. silvestrii was extreme in runoff samples, whereas eluates were by far the least toxic samples. A generally higher toxicity was found in the bioassays performed with samples from the field trial, indicating the need for improvements in the laboratory simulator. However, the tool developed proved to be valuable in evaluating the toxic effects of pesticide spraying in soils and the potential risks for aquatic compartments. Copyright © 2011 SETAC.

Visual receptive field properties of cells in the optic tectum of the archer fish.

PubMed

Ben-Tov, Mor; Kopilevich, Ivgeny; Donchin, Opher; Ben-Shahar, Ohad; Giladi, Chen; Segev, Ronen

2013-08-01

The archer fish is well known for its extreme visual behavior in shooting water jets at prey hanging on vegetation above water. This fish is a promising model in the study of visual system function because it can be trained to respond to artificial targets and thus to provide valuable psychophysical data. Although much behavioral data have indeed been collected over the past two decades, little is known about the functional organization of the main visual area supporting this visual behavior, namely, the fish optic tectum. In this article we focus on a fundamental aspect of this functional organization and provide a detailed analysis of receptive field properties of cells in the archer fish optic tectum. Using extracellular measurements to record activities of single cells, we first measure their retinotectal mapping. We then determine their receptive field properties such as size, selectivity for stimulus direction and orientation, tuning for spatial frequency, and tuning for temporal frequency. Finally, on the basis of all these measurements, we demonstrate that optic tectum cells can be classified into three categories: orientation-tuned cells, direction-tuned cells, and direction-agnostic cells. Our results provide an essential basis for future investigations of information processing in the archer fish visual system.

Increasing value and reducing waste in research design, conduct, and analysis.

PubMed

Ioannidis, John P A; Greenland, Sander; Hlatky, Mark A; Khoury, Muin J; Macleod, Malcolm R; Moher, David; Schulz, Kenneth F; Tibshirani, Robert

2014-01-11

Correctable weaknesses in the design, conduct, and analysis of biomedical and public health research studies can produce misleading results and waste valuable resources. Small effects can be difficult to distinguish from bias introduced by study design and analyses. An absence of detailed written protocols and poor documentation of research is common. Information obtained might not be useful or important, and statistical precision or power is often too low or used in a misleading way. Insufficient consideration might be given to both previous and continuing studies. Arbitrary choice of analyses and an overemphasis on random extremes might affect the reported findings. Several problems relate to the research workforce, including failure to involve experienced statisticians and methodologists, failure to train clinical researchers and laboratory scientists in research methods and design, and the involvement of stakeholders with conflicts of interest. Inadequate emphasis is placed on recording of research decisions and on reproducibility of research. Finally, reward systems incentivise quantity more than quality, and novelty more than reliability. We propose potential solutions for these problems, including improvements in protocols and documentation, consideration of evidence from studies in progress, standardisation of research efforts, optimisation and training of an experienced and non-conflicted scientific workforce, and reconsideration of scientific reward systems. Copyright © 2014 Elsevier Ltd. All rights reserved.

High-resolution near real-time drought monitoring in South Asia

NASA Astrophysics Data System (ADS)

Aadhar, Saran; Mishra, Vimal

2017-10-01

Drought in South Asia affect food and water security and pose challenges for millions of people. For policy-making, planning, and management of water resources at sub-basin or administrative levels, high-resolution datasets of precipitation and air temperature are required in near-real time. We develop a high-resolution (0.05°) bias-corrected precipitation and temperature data that can be used to monitor near real-time drought conditions over South Asia. Moreover, the dataset can be used to monitor climatic extremes (heat and cold waves, dry and wet anomalies) in South Asia. A distribution mapping method was applied to correct bias in precipitation and air temperature, which performed well compared to the other bias correction method based on linear scaling. Bias-corrected precipitation and temperature data were used to estimate Standardized precipitation index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI) to assess the historical and current drought conditions in South Asia. We evaluated drought severity and extent against the satellite-based Normalized Difference Vegetation Index (NDVI) anomalies and satellite-driven Drought Severity Index (DSI) at 0.05°. The bias-corrected high-resolution data can effectively capture observed drought conditions as shown by the satellite-based drought estimates. High resolution near real-time dataset can provide valuable information for decision-making at district and sub-basin levels.

Transcriptomic analysis of Crassostrea sikamea × Crassostrea angulata hybrids in response to low salinity stress

PubMed Central

Yan, Lulu; Su, Jiaqi; Wang, Zhaoping; Yan, Xiwu; Yu, Ruihai; Ma, Peizhen; Li, Yangchun; Du, Junpeng

2017-01-01

Hybrid oysters often show heterosis in growth rate, weight, survival and adaptability to extremes of salinity. Oysters have also been used as model organisms to study the evolution of host-defense system. To gain comprehensive knowledge about various physiological processes in hybrid oysters under low salinity stress, we performed transcriptomic analysis of gill tissue of Crassostrea sikamea ♀ × Crassostrea angulata♂ hybrid using the deep-sequencing platform Illumina HiSeq. We exploited the high-throughput technique to delineate differentially expressed genes (DEGs) in oysters maintained in hypotonic conditions. A total of 199,391 high quality unigenes, with average length of 644 bp, were generated. Of these 35 and 31 genes showed up- and down-regulation, respectively. Functional categorization and pathway analysis of these DEGs revealed enrichment for immune mechanism, apoptosis, energy metabolism and osmoregulation under low salinity stress. The expression patterns of 41 DEGs in hybrids and their parental species were further analyzed by quantitative real-time PCR (qRT-PCR). This study will serve as a platform for subsequent gene expression analysis regarding environmental stress. Our findings will also provide valuable information about gene expression to better understand the immune mechanism, apoptosis, energy metabolism and osmoregulation in hybrid oysters under low salinity stress. PMID:28182701

Regional assessment of lake ecological states using Landsat: A classification scheme for alkaline-saline, flamingo lakes in the East African Rift Valley

NASA Astrophysics Data System (ADS)

Tebbs, E. J.; Remedios, J. J.; Avery, S. T.; Rowland, C. S.; Harper, D. M.

2015-08-01

In situ reflectance measurements and Landsat satellite imagery were combined to develop an optical classification scheme for alkaline-saline lakes in the Eastern Rift Valley. The classification allows the ecological state and consequent value, in this case to Lesser Flamingos, to be determined using Landsat satellite imagery. Lesser Flamingos depend on a network of 15 alkaline-saline lakes in East African Rift Valley, where they feed by filtering cyanobacteria and benthic diatoms from the lakes' waters. The classification developed here was based on a decision tree which used the reflectance in Landsat ETM+ bands 2-4 to assign one of six classes: low phytoplankton biomass; suspended sediment-dominated; microphytobenthos; high cyanobacterial biomass; cyanobacterial scum and bleached cyanobacterial scum. The classification accuracy was 77% when verified against in situ measurements. Classified imagery and timeseries were produced for selected lakes, which show the different ecological behaviours of these complex systems. The results have highlighted the importance to flamingos of the food resources offered by the extremely remote Lake Logipi. This study has demonstrated the potential of high spatial resolution, low spectral resolution sensors for providing ecologically valuable information at a regional scale, for alkaline-saline lakes and similar hypereutrophic inland waters.

Structure simulation into a lamellar supramolecular network and calculation of the metal ions/ligands ratio

PubMed Central

2012-01-01

Background Research interest in phosphonates metal organic frameworks (MOF) has increased extremely in the last two decades, because of theirs fascinating and complex topology and structural flexibility. In this paper we present a mathematical model for ligand/metal ion ratio of an octahedral (Oh) network of cobalt vinylphosphonate (Co(vP)·H2O). Results A recurrent relationship of the ratio between the number of ligands and the number of metal ions in a lamellar octahedral (Oh) network Co(vP)·H2O, has been deducted by building the 3D network step by step using HyperChem 7.52 package. The mathematical relationship has been validated using X ray analysis, experimental thermogravimetric and elemental analysis data. Conclusions Based on deducted recurrence relationship, we can conclude prior to perform X ray analysis, that in the case of a thermogravimetric analysis pointing a ratio between the number of metal ions and ligands number around 1, the 3D network will have a central metal ion that corresponds to a single ligand. This relation is valid for every type of supramolecular network with divalent metal central ion Oh coordinated and bring valuable information with low effort and cost. PMID:22932493

Analysis strategies for high-resolution UHF-fMRI data.

PubMed

Polimeni, Jonathan R; Renvall, Ville; Zaretskaya, Natalia; Fischl, Bruce

2018-03-01

Functional MRI (fMRI) benefits from both increased sensitivity and specificity with increasing magnetic field strength, making it a key application for Ultra-High Field (UHF) MRI scanners. Most UHF-fMRI studies utilize the dramatic increases in sensitivity and specificity to acquire high-resolution data reaching sub-millimeter scales, which enable new classes of experiments to probe the functional organization of the human brain. This review article surveys advanced data analysis strategies developed for high-resolution fMRI at UHF. These include strategies designed to mitigate distortion and artifacts associated with higher fields in ways that attempt to preserve spatial resolution of the fMRI data, as well as recently introduced analysis techniques that are enabled by these extremely high-resolution data. Particular focus is placed on anatomically-informed analyses, including cortical surface-based analysis, which are powerful techniques that can guide each step of the analysis from preprocessing to statistical analysis to interpretation and visualization. New intracortical analysis techniques for laminar and columnar fMRI are also reviewed and discussed. Prospects for single-subject individualized analyses are also presented and discussed. Altogether, there are both specific challenges and opportunities presented by UHF-fMRI, and the use of proper analysis strategies can help these valuable data reach their full potential. Copyright © 2017 Elsevier Inc. All rights reserved.

Space research on organs and tissues

NASA Technical Reports Server (NTRS)

Tischler, Marc E.; Morey-Holton, Emily

1993-01-01

Studies in space on various physiological systems have and will continue to provide valuable information on how they adapt to reduced gravitational conditions, and how living in a 1 g (gravity) environment has guided their development. Muscle and bone are the most notable tissues that respond to unweighting caused by lack of gravity. The function of specific muscles and bones relates directly to mechanical loading, so that removal of 'normal forces' in space, or in bedridden patients, causes dramatic loss of tissue mass. The cardiovascular system is also markedly affected by reduced gravity. Adaptation includes decreased blood flow to the lower extremities, thus decreasing the heart output requirement. Return to 1 g is associated with a period of reconditioning due to the deconditioning that occurs in space. Changes in the cardiovascular system are also related to responses of the kidney and certain endocrine (hormone-producing) organs. Changes in respiratory function may also occur, suggesting an effect on the lungs, though this adaptation is poorly understood. The neurovestibular system, including the brain and organs of the inner ear, must adapt to the disorientation caused by lack of gravity. Preliminary findings have been reported for liver. Additionally, endocrine organs responsible for release of hormones such as insulin, growth hormone, glucocorticoids, and thyroid hormone may respond to spaceflight.

Classification accuracy of claims-based methods for identifying providers failing to meet performance targets.

PubMed

Hubbard, Rebecca A; Benjamin-Johnson, Rhondee; Onega, Tracy; Smith-Bindman, Rebecca; Zhu, Weiwei; Fenton, Joshua J

2015-01-15

Quality assessment is critical for healthcare reform, but data sources are lacking for measurement of many important healthcare outcomes. With over 49 million people covered by Medicare as of 2010, Medicare claims data offer a potentially valuable source that could be used in targeted health care quality improvement efforts. However, little is known about the operating characteristics of provider profiling methods using claims-based outcome measures that may estimate provider performance with error. Motivated by the example of screening mammography performance, we compared approaches to identifying providers failing to meet guideline targets using Medicare claims data. We used data from the Breast Cancer Surveillance Consortium and linked Medicare claims to compare claims-based and clinical estimates of cancer detection rate. We then demonstrated the performance of claim-based estimates across a broad range of operating characteristics using simulation studies. We found that identification of poor performing providers was extremely sensitive to algorithm specificity, with no approach identifying more than 65% of poor performing providers when claims-based measures had specificity of 0.995 or less. We conclude that claims have the potential to contribute important information on healthcare outcomes to quality improvement efforts. However, to achieve this potential, development of highly accurate claims-based outcome measures should remain a priority. Copyright © 2014 John Wiley & Sons, Ltd.

Observations on military exploitation of explosives detection technologies

NASA Astrophysics Data System (ADS)

Faust, Anthony A.; de Ruiter, C. J.; Ehlerding, Anneli; McFee, John E.; Svinsås, Eirik; van Rheenen, Arthur D.

2011-06-01

Accurate and timely detection of explosives, energetic materials, and their associated compounds would provide valuable information to military commanders in a wide range of military operations: protection of fast moving convoys from mobile or static IED threats; more deliberate countermine and counter-IED operations during route or area clearance; and static roles such as hasty or deliberate checkpoints, critical infrastructure protection and support to public security. The detection of hidden explosive hazards is an extremely challenging problem, as evidenced by the fact that related research has been ongoing in many countries for at least seven decades and no general purpose solution has yet been found. Technologies investigated have spanned all major scientific fields, with emphasis on the physical sciences, life sciences, engineering, robotics, computer technology and mathematics. This paper will present a limited, operationally-focused overview of the current status of detection technologies. Emphasis will be on those technologies that directly detect the explosive hazard, as opposed to those that detect secondary properties of the threat, such as the casing, associated wires or electronics. Technologies that detect explosives include those based on nuclear radiation and terahertz radiation, as well as trace and biological detection techniques. Current research areas of the authors will be used to illustrate the practical applications.

NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.

PubMed

Wang, Jianjian; Cao, Yuze; Zhang, Huixue; Wang, Tianfeng; Tian, Qinghua; Lu, Xiaoyu; Lu, Xiaoyan; Kong, Xiaotong; Liu, Zhaojun; Wang, Ning; Zhang, Shuai; Ma, Heping; Ning, Shangwei; Wang, Lihua

2017-01-04

The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD-ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD-ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Intelligent route surveillance

NASA Astrophysics Data System (ADS)

Schoemaker, Robin; Sandbrink, Rody; van Voorthuijsen, Graeme

2009-05-01

Intelligence on abnormal and suspicious behaviour along roads in operational domains is extremely valuable for countering the IED (Improvised Explosive Device) threat. Local sensor networks at strategic spots can gather data for continuous monitoring of daily vehicle activity. Unattended intelligent ground sensor networks use simple sensing nodes, e.g. seismic, magnetic, radar, or acoustic, or combinations of these in one housing. The nodes deliver rudimentary data at any time to be processed with software that filters out the required information. At TNO (Netherlands Organisation for Applied Scientific Research) research has started on how to equip a sensor network with data analysis software to determine whether behaviour is suspicious or not. Furthermore, the nodes should be expendable, if necessary, and be small in size such that they are hard to detect by adversaries. The network should be self-configuring and self-sustaining and should be reliable, efficient, and effective during operational tasks - especially route surveillance - as well as robust in time and space. If data from these networks are combined with data from other remote sensing devices (e.g. UAVs (Unmanned Aerial Vehicles)/aerostats), an even more accurate assessment of the tactical situation is possible. This paper shall focus on the concepts of operation towards a working intelligent route surveillance (IRS) research demonstrator network for monitoring suspicious behaviour in IED sensitive domains.

Statistical physics of crime: a review.

PubMed

D'Orsogna, Maria R; Perc, Matjaž

2015-03-01

Containing the spread of crime in urban societies remains a major challenge. Empirical evidence suggests that, if left unchecked, crimes may be recurrent and proliferate. On the other hand, eradicating a culture of crime may be difficult, especially under extreme social circumstances that impair the creation of a shared sense of social responsibility. Although our understanding of the mechanisms that drive the emergence and diffusion of crime is still incomplete, recent research highlights applied mathematics and methods of statistical physics as valuable theoretical resources that may help us better understand criminal activity. We review different approaches aimed at modeling and improving our understanding of crime, focusing on the nucleation of crime hotspots using partial differential equations, self-exciting point process and agent-based modeling, adversarial evolutionary games, and the network science behind the formation of gangs and large-scale organized crime. We emphasize that statistical physics of crime can relevantly inform the design of successful crime prevention strategies, as well as improve the accuracy of expectations about how different policing interventions should impact malicious human activity that deviates from social norms. We also outline possible directions for future research, related to the effects of social and coevolving networks and to the hierarchical growth of criminal structures due to self-organization. Copyright © 2014 Elsevier B.V. All rights reserved.

An important Norwegian contribution to the study of the bursae of the upper and lower extremities.

PubMed

Musil, Vladimir; Selnes, Christoffer V; Falck, Aleksander T; Sandve, Lars; Shekarchi, Siamek; O'Donnell, Bruce; Kachlik, David

2010-10-01

We present a critical analysis of the monograph of A.S.D. Synnestvedt (1869) “En anatomisk beskrivelse af de paa over- og underestremiteterne forekommende Bursae mucosae”. The analysis was completed using anatomical information from the historically oldest publications dealing with the bursae of the extremities: Albinus (1734) , Monro (1788) , Rosenmüller (1799) . We are of the opinion that Synnestvedt's publication is important, not only historically but also as a source of information for recent medical practitioners. Synnestvedt's monograph has a wealth of literary citations, unambiguous opinions of seasoned anatomists regarding the structure and function of the synovial membrane, and detailed descriptions of dissections he performed on fetal and adult cadavers. The information in this publication may enhance the diagnosis of bursopathies and enthesopathies of the extremities.

An important Norwegian contribution to the study of the bursae of the upper and lower extremities

PubMed Central

2010-01-01

We present a critical analysis of the monograph of A.S.D. Synnestvedt (1869) “En anatomisk beskrivelse af de paa over- og underestremiteterne forekommende Bursae mucosae”. The analysis was completed using anatomical information from the historically oldest publications dealing with the bursae of the extremities: Albinus (1734), Monro (1788), Rosenmüller (1799). We are of the opinion that Synnestvedt's publication is important, not only historically but also as a source of information for recent medical practitioners. Synnestvedt's monograph has a wealth of literary citations, unambiguous opinions of seasoned anatomists regarding the structure and function of the synovial membrane, and detailed descriptions of dissections he performed on fetal and adult cadavers. The information in this publication may enhance the diagnosis of bursopathies and enthesopathies of the extremities. PMID:20860444

Living with extreme weather events - perspectives from climatology, geomorphological analysis, chronicles and opinion polls

NASA Astrophysics Data System (ADS)

Auer, I.; Kirchengast, A.; Proske, H.

2009-09-01

The ongoing climate change debate focuses more and more on changing extreme events. Information on past events can be derived from a number of sources, such as instrumental data, residual impacts in the landscape, but also chronicles and people's memories. A project called "A Tale of Two Valleys” within the framework of the research program "proVision” allowed to study past extreme events in two inner-alpine valleys from the sources mentioned before. Instrumental climate time series provided information for the past 200 years, however great attention had to be given to the homogeneity of the series. To derive homogenized time series of selected climate change indices methods like HOCLIS and Vincent have been applied. Trend analyses of climate change indices inform about increase or decrease of extreme events. Traces of major geomorphodynamic processes of the past (e.g. rockfalls, landslides, debris flows) which were triggered or affected by extreme weather events are still apparent in the landscape and could be evaluated by geomorphological analysis using remote sensing and field data. Regional chronicles provided additional knowledge and covered longer periods back in time, however compared to meteorological time series they enclose a high degree of subjectivity and intermittent recordings cannot be obviated. Finally, questionnaires and oral history complemented our picture of past extreme weather events. People were differently affected and have different memories of it. The joint analyses of these four data sources showed agreement to some extent, however also showed some reasonable differences: meteorological data are point measurements only with a sometimes too coarse temporal resolution. Due to land-use changes and improved constructional measures the impact of an extreme meteorological event may be different today compared to earlier times.

Skill of a global seasonal ensemble streamflow forecasting system

NASA Astrophysics Data System (ADS)

Candogan Yossef, Naze; Winsemius, Hessel; Weerts, Albrecht; van Beek, Rens; Bierkens, Marc

2013-04-01

Forecasting of water availability and scarcity is a prerequisite for managing the risks and opportunities caused by the inter-annual variability of streamflow. Reliable seasonal streamflow forecasts are necessary to prepare for an appropriate response in disaster relief, management of hydropower reservoirs, water supply, agriculture and navigation. Seasonal hydrological forecasting on a global scale could be valuable especially for developing regions of the world, where effective hydrological forecasting systems are scarce. In this study, we investigate the forecasting skill of the global seasonal streamflow forecasting system FEWS-World, using the global hydrological model PCR-GLOBWB. FEWS-World has been setup within the European Commission 7th Framework Programme project Global Water Scarcity Information Service (GLOWASIS). Skill is assessed in historical simulation mode as well as retroactive forecasting mode. The assessment in historical simulation mode used a meteorological forcing based on observations from the Climate Research Unit of the University of East Anglia and the ERA-40 reanalysis of the European Center for Medium-Range Weather Forecasts (ECMWF). We assessed the skill of the global hydrological model PCR-GLOBWB in reproducing past discharge extremes in 20 large rivers of the world. This preliminary assessment concluded that the prospects for seasonal forecasting with PCR-GLOBWB or comparable models are positive. However this assessment did not include actual meteorological forecasts. Thus the meteorological forcing errors were not assessed. Yet, in a forecasting setup, the predictive skill of a hydrological forecasting system is affected by errors due to uncertainty from numerical weather prediction models. For the assessment in retroactive forecasting mode, the model is forced with actual ensemble forecasts from the seasonal forecast archives of ECMWF. Skill is assessed at 78 stations on large river basins across the globe, for all the months of the year and for lead times up to 6 months. The forecasted discharges are compared with observed monthly streamflow records using the ensemble verification measures Brier Skill Score (BSS) and Continuous Ranked Probability Score (CRPS). The eventual goal is to transfer FEWS-World to operational forecasting mode, where the system will use operational seasonal forecasts from ECMWF. The results will be disseminated on the internet, and hopefully provide information that is valuable for users in data and model-poor regions of the world.

NASA's Contribution to Water Research, Applications and Capacity Building in the America's

NASA Astrophysics Data System (ADS)

Toll, D. L.; Searby, N. D.; Doorn, B.; Lawford, R. G.; Entin, J. K.; Mohr, K. I.; Lee, C.; NASA International Water Team

2013-05-01

NASA's water research, applications and capacity building activities use satellites and models to contribute to regional water information and solutions for the Americas. Free and open exchange of Earth data observations and products helps engage and improve integrated observation networks and enables national and multi-national regional water cycle research and applications. NASA satellite and modeling products provide a huge volume of valuable data extending back over 50 years across a broad range of spatial (local to global) and temporal (hourly to decadal) scales and include many products that are available in near real time (see earthdata.nasa.gov). In addition, NASA's work in hydrologic predictions are valuable for: 1) short-term and hourly data that is critical for flood and landslide warnings; 2) mid-term predictions of days to weeks useful for reservoir planning and water allocation, and 3) long term seasonal to decadal forecasts helpful for agricultural and irrigation planning, land use planning, and water infrastructure development and planning. To further accomplish these objectives NASA works to actively partner with public and private groups (e.g. federal agencies, universities, NGO's, and industry) in the U.S. and internationally to ensure the broadest use of its satellites and related information and products and to collaborate with regional end users who know the regions and their needs best. Through these data, policy and partnering activities, NASA addresses numerous water issues including water scarcity, the extreme events of drought and floods, and water quality so critical to the Americas. This presentation will outline and describe NASA's water related research, applications and capacity building programs' efforts to address the Americas' critical water challenges. This will specifically include water activities in NASA's programs in Terrestrial Hydrology (e.g., land-atmosphere feedbacks and improved stream flow estimation), Water Resources (e.g., drought, snow-pack and agriculture projects), and Disasters (e.g., flooding and landslides), and Capacity Building (e.g., 'SERVIR' science visualizations and environmental monitoring). The presentation will also demonstrate how NASA is a major contributor to water tasks and activities in GEOSS (Global Earth Observing System of Systems) in the Americas as well as USGEO and the international GEO (Group on Earth Observations) activities and to global environmental change research.

Organ dose measurements from multiple-detector computed tomography using a commercial dosimetry system and tomographic, physical phantoms

NASA Astrophysics Data System (ADS)

Lavoie, Lindsey K.

The technology of computed tomography (CT) imaging has soared over the last decade with the use of multi-detector CT (MDCT) scanners that are capable of performing studies in a matter of seconds. While the diagnostic information obtained from MDCT imaging is extremely valuable, it is important to ensure that the radiation doses resulting from these studies are at acceptably safe levels. This research project focused on the measurement of organ doses resulting from modern MDCT scanners. A commercially-available dosimetry system was used to measure organ doses. Small dosimeters made of optically-stimulated luminescent (OSL) material were analyzed with a portable OSL reader. Detailed verification of this system was performed. Characteristics studied include energy, scatter, and angular responses; dose linearity, ability to erase the exposed dose and ability to reuse dosimeters multiple times. The results of this verification process were positive. While small correction factors needed to be applied to the dose reported by the OSL reader, these factors were small and expected. Physical, tomographic pediatric and adult phantoms were used to measure organ doses. These phantoms were developed from CT images and are composed of tissue-equivalent materials. Because the adult phantom is comprised of numerous segments, dosimeters were placed in the phantom at several organ locations, and doses to select organs were measured using three clinical protocols: pediatric craniosynostosis, adult brain perfusion and adult cardiac CT angiography (CTA). A wide-beam, 320-slice, volumetric CT scanner and a 64-slice, MDCT scanner were used for organ dose measurements. Doses ranged from 1 to 26 mGy for the pediatric protocol, 1 to 1241 mGy for the brain perfusion protocol, and 2-100 mGy for the cardiac protocol. In most cases, the doses measured on the 64-slice scanner were higher than those on the 320-slice scanner. A methodology to measure organ doses with OSL dosimeters received from CT imaging has been presented. These measurements are especially important in keeping with the ALARA (as low as reasonably achievable) principle. While diagnostic information from CT imaging is valuable and necessary, the dose to patients is always a consideration. This methodology aids in this important task. (Full text of this dissertation may be available via the University of Florida Libraries web site. Please check http://www.uflib.ufl.edu/etd.html)

USACE Extreme Sea levels

DTIC Science & Technology

2014-03-14

with expected changes due to climate change. (tropicals and extra-tropicals) Ivan provided some good information on work being done on tropical...Pattiaratchi, C., Jensen, J., 2013. Estimating extreme water level probabilities: a comparison of the direct methods and recommendations for best practise ...sites: site-by-site analyses. Proudman Oceanographic Laboratory , Internal Document, No. 65, 229pp. Dixon, M.J., Tawn, J.A. (1995) Extreme sea-levels

Case Study: The Transfer of Tacit Knowledge from Community College Full-Time to Adjunct Faculty

ERIC Educational Resources Information Center

Guzzo, Linda R.

2013-01-01

Knowledge is a valuable resource that fosters innovation and growth in organizations. There are two forms of knowledge: explicit knowledge or documented information and tacit knowledge or undocumented information which resides in individuals' minds. There is heightened interest in knowledge management and specifically the transfer of tacit…

The Mentor inside You

ERIC Educational Resources Information Center

Kerlin, Christine

2016-01-01

Mentoring occurs in formal and informal ways. While formal mentoring programs are valuable, the majority of people are likely to have opportunities for informal mentoring in their workplace and in their communities. The author makes the point that mentors are all around us, and each of us may have the capacity to mentor or to be mentored, whether…

The Value of School Librarian Support in the Digital World

ERIC Educational Resources Information Center

Ballew, Linda M.

2014-01-01

The mission of school librarians in the digital age of information gathering and messaging has not undergone any real change of focus. Even though the tools and methods available for accessing information have significantly altered the way people now use library services, school libraries remain a constant place to make valuable discoveries. The…

76 FR 77236 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... provide valuable information on the effects of these programs on parents and children. This includes... time of the child's first birthday. These data will include a one-hour interview with the parent and 30-minutes of observed interactions between the parent and child. This notice does not seek comment on these...

Surveillance in the Information Age: Text Quantification, Anomaly Detection, and Empirical Evaluation

ERIC Educational Resources Information Center

Lu, Hsin-Min

2010-01-01

Deep penetration of personal computers, data communication networks, and the Internet has created a massive platform for data collection, dissemination, storage, and retrieval. Large amounts of textual data are now available at a very low cost. Valuable information, such as consumer preferences, new product developments, trends, and opportunities,…

Opt-Outs: What Is Lost When Students Do Not Test. Issue Brief

ERIC Educational Resources Information Center

Croft, Michelle

2015-01-01

Scores on annual statewide achievement tests can provide parents, students, educators, and policymakers with valuable information--but only if students participate. This issue brief provides the background about recent increases in (and efforts to expand) the number of students opting out of statewide assessments, describes the information and…

The Pursuit of Equality: Retaining Women in Information Technology

ERIC Educational Resources Information Center

Ehlert, Teresa

2017-01-01

This qualitative study employed a three-iteration classical Delphi design to determine consensus regarding retention strategies of women in the IT industry. There is a call for the information technology (IT) industry to hire and retain more women. Retaining such a valuable educated source would help fill the ever-rising need for skilled workers…

Vermont hospital's web site focuses on valuable healthcare information.

PubMed

Rees, Tom

2005-01-01

Brattleboro Memorial Hospital's web site celebrates a century of caring in the region of Brattleboro, Vt. The web site, bmhvt.org, is loaded with information, including a local links page that enables site visitors to hook up with the Brattleboro Chamber of Commerce, the Area Health Education Council, Lifeline Personal Response Service, and more.

DNA fingerprinting sets for four southern pines

Treesearch

Craig Echt; Sedley Josserand

2018-01-01

DNA markers can provide valuable genetic information for forest tree research, breeding, conservation, and restoration programs. When properly evaluated, selected sets of DNA markers can be used to efficiently get information about genetic diversity in regions, forests, or stands, or in seed lots and orchards. Selected markers also can be used to determine parentage or...

Level of Agreement between Self and Spouse in the Assessment of Personality Pathology

ERIC Educational Resources Information Center

South, Susan C.; Oltmanns, Thomas F.; Johnson, Jarrod; Turkheimer, Eric

2011-01-01

Informant reports can provide important information regarding the presence of pathological personality traits, and they can serve as useful supplements to self-report instruments. Ratings from a spouse may be a particularly valuable source of personality assessment because spouses are very well acquainted with the target person, have typically…

Communication Processes in the Field Research Interview Setting: A Case Study.

ERIC Educational Resources Information Center

Mason, Susan A.

For those involved in research of any type, the gathering of complete, relevant, and untainted information is the ultimate goal. The collection of valuable information is particularly challenging in the social sciences, which often call for qualitative field research. The effective field research interviewer must not only be knowledgeable of the…

The Necessity of Environmental Scanning Prior to Long-Range Planning Activities at Higher Education Institutions.

ERIC Educational Resources Information Center

Handy, Ty J.

Formal environmental scanning procedures can provide key administrators of higher education institutions with valuable external information regarding both the probability and impact of external trends and forces. Such information may then be used in various strategic planning stages including scenario development, institutional mission and goals…

The Big Read: Case Studies

ERIC Educational Resources Information Center

National Endowment for the Arts, 2009

2009-01-01

The Big Read evaluation included a series of 35 case studies designed to gather more in-depth information on the program's implementation and impact. The case studies gave readers a valuable first-hand look at The Big Read in context. Both formal and informal interviews, focus groups, attendance at a wide range of events--all showed how…

Microbial profiling, neural network and semantic web: an integrated information system for human pathogen risk management, prevention and surveillance in food safety

USDA-ARS?s Scientific Manuscript database

It is estimated that food-borne pathogens cause approximately 76 million cases of gastrointestinal illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States annually. Genomic, proteomic, and metabolomic studies, particularly, genome sequencing projects are providing valuable inform...

Business Intelligence Applied to the ALMA Software Integration Process

NASA Astrophysics Data System (ADS)

Zambrano, M.; Recabarren, C.; González, V.; Hoffstadt, A.; Soto, R.; Shen, T.-C.

2012-09-01

Software quality assurance and planning of an astronomy project is a complex task, specially if it is a distributed collaborative project such as ALMA, where the development centers are spread across the globe. When you execute a software project there is much valuable information about this process itself that you might be able to collect. One of the ways you can receive this input is via an issue tracking system that will gather the problem reports relative to software bugs captured during the testing of the software, during the integration of the different components or even worst, problems occurred during production time. Usually, there is little time spent on analyzing them but with some multidimensional processing you can extract valuable information from them and it might help you on the long term planning and resources allocation. We present an analysis of the information collected at ALMA from a collection of key unbiased indicators. We describe here the extraction, transformation and load process and how the data was processed. The main goal is to assess a software process and get insights from this information.

Extreme Rainfall Analysis using Bayesian Hierarchical Modeling in the Willamette River Basin, Oregon

NASA Astrophysics Data System (ADS)

Love, C. A.; Skahill, B. E.; AghaKouchak, A.; Karlovits, G. S.; England, J. F.; Duren, A. M.

2016-12-01

We present preliminary results of ongoing research directed at evaluating the worth of including various covariate data to support extreme rainfall analysis in the Willamette River basin using Bayesian hierarchical modeling (BHM). We also compare the BHM derived extreme rainfall estimates with their respective counterparts obtained from a traditional regional frequency analysis (RFA) using the same set of rain gage extreme rainfall data. The U.S. Army Corps of Engineers (USACE) Portland District operates thirteen dams in the 11,478 square mile Willamette River basin (WRB) located in northwestern Oregon, a major tributary of the Columbia River whose 187 miles long main stem, the Willamette River, flows northward between the Coastal and Cascade Ranges. The WRB contains approximately two-thirds of Oregon's population and 20 of the 25 most populous cities in the state. Extreme rainfall estimates are required to support risk-informed hydrologic analyses for these projects as part of the USACE Dam Safety Program. We analyze daily annual rainfall maxima data for the WRB utilizing the spatial BHM R package "spatial.gev.bma", which has been shown to be efficient in developing coherent maps of extreme rainfall by return level. Our intent is to profile for the USACE an alternate methodology to a RFA which was developed in 2008 due to the lack of an official NOAA Atlas 14 update for the state of Oregon. Unlike RFA, the advantage of a BHM-based analysis of hydrometeorological extremes is its ability to account for non-stationarity while providing robust estimates of uncertainty. BHM also allows for the inclusion of geographical and climatological factors which we show for the WRB influence regional rainfall extremes. Moreover, the Bayesian framework permits one to combine additional data types into the analysis; for example, information derived via elicitation and causal information expansion data, both being additional opportunities for future related research.

Upper-extremity and mobility subdomains from the Patient-Reported Outcomes Measurement Information System (PROMIS) adult physical functioning item bank.

PubMed

Hays, Ron D; Spritzer, Karen L; Amtmann, Dagmar; Lai, Jin-Shei; Dewitt, Esi Morgan; Rothrock, Nan; Dewalt, Darren A; Riley, William T; Fries, James F; Krishnan, Eswar

2013-11-01

To create upper-extremity and mobility subdomain scores from the Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning adult item bank. Expert reviews were used to identify upper-extremity and mobility items from the PROMIS item bank. Psychometric analyses were conducted to assess empirical support for scoring upper-extremity and mobility subdomains. Data were collected from the U.S. general population and multiple disease groups via self-administered surveys. The sample (N=21,773) included 21,133 English-speaking adults who participated in the PROMIS wave 1 data collection and 640 Spanish-speaking Latino adults recruited separately. Not applicable. We used English- and Spanish-language data and existing PROMIS item parameters for the physical functioning item bank to estimate upper-extremity and mobility scores. In addition, we fit graded response models to calibrate the upper-extremity items and mobility items separately, compare separate to combined calibrations, and produce subdomain scores. After eliminating items because of local dependency, 16 items remained to assess upper extremity and 17 items to assess mobility. The estimated correlation between upper extremity and mobility was .59 using existing PROMIS physical functioning item parameters (r=.60 using parameters calibrated separately for upper-extremity and mobility items). Upper-extremity and mobility subdomains shared about 35% of the variance in common, and produced comparable scores whether calibrated separately or together. The identification of the subset of items tapping these 2 aspects of physical functioning and scored using the existing PROMIS parameters provides the option of scoring these subdomains in addition to the overall physical functioning score. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Constructing Concept Schemes From Astronomical Telegrams Via Natural Language Clustering

NASA Astrophysics Data System (ADS)

Graham, Matthew; Zhang, M.; Djorgovski, S. G.; Donalek, C.; Drake, A. J.; Mahabal, A.

2012-01-01

The rapidly emerging field of time domain astronomy is one of the most exciting and vibrant new research frontiers, ranging in scientific scope from studies of the Solar System to extreme relativistic astrophysics and cosmology. It is being enabled by a new generation of large synoptic digital sky surveys - LSST, PanStarrs, CRTS - that cover large areas of sky repeatedly, looking for transient objects and phenomena. One of the biggest challenges facing these is the automated classification of transient events, a process that needs machine-processible astronomical knowledge. Semantic technologies enable the formal representation of concepts and relations within a particular domain. ATELs (http://www.astronomerstelegram.org) are a commonly-used means for reporting and commenting upon new astronomical observations of transient sources (supernovae, stellar outbursts, blazar flares, etc). However, they are loose and unstructured and employ scientific natural language for description: this makes automated processing of them - a necessity within the next decade with petascale data rates - a challenge. Nevertheless they represent a potentially rich corpus of information that could lead to new and valuable insights into transient phenomena. This project lies in the cutting-edge field of astrosemantics, a branch of astroinformatics, which applies semantic technologies to astronomy. The ATELs have been used to develop an appropriate concept scheme - a representation of the information they contain - for transient astronomy using hierarchical clustering of processed natural language. This allows us to automatically organize ATELs based on the vocabulary used. We conclude that we can use simple algorithms to process and extract meaning from astronomical textual data.

Homicidal deaths by firearms in Peshawar: an autopsy study.

PubMed

Hussain, Zahid; Shah, Mian Mujahid; Afridi, Hakim Khan; Arif, Muhammad

2006-01-01

Medico legal autopsies can be valuable sources of information about the distribution of causes of reported deaths, particularly in homicidal cases. The present study provides information regarding the homicidal deaths due to firearm injuries in the district of Peshawar, NWFP, Pakistan. This descriptive study was conducted over the period of the year 2004. Data were collected from the autopsy records of the Department of Forensic Medicine, Khyber Medical College Peshawar and included all reported unnatural deaths from urban and rural areas of district Peshawar on whom autopsies were conducted in the department. Homicidal deaths constituted 77.7% (492/633) of all autopsies for the year 2004. Of 492 homicidal deaths, a vast majority of 452 (91.87%) were caused by firearm injuries. Among these, the male to female ratio was 5.5:1. The most common firearm weapon (418/452, 92.5%) were high velocity rifled weapons (Kalashnikov, rifles, pistols), followed by low velocity rifled weapons (18/452, 3.98%) and shotguns (16/452, 3.54%). A total of 956 injuries were found in various body areas, giving an average of over two injuries per person. The head, face and neck sustained the highest injuries (257, 26.9%), followed by the chest (248, 25.9%) and abdomen (149, 15.6%); the extremities, buttocks and genitalia together sustained 302 (31.6%) injuries. The vast majority of reported homicides in Peshawar are caused by firearm injuries, which bring up issues related to possession of firearms and changes in cultural attitudes towards use of firearms, if a decrease in firearm-related homicides is desired.

Modeling flows and concentrations of nine engineered nanomaterials in the Danish environment.

PubMed

Gottschalk, Fadri; Lassen, Carsten; Kjoelholt, Jesper; Christensen, Frans; Nowack, Bernd

2015-05-22

Predictions of environmental concentrations of engineered nanomaterials (ENM) are needed for their environmental risk assessment. Because analytical data on ENM-concentrations in the environment are not yet available, exposure modeling represents the only source of information on ENM exposure in the environment. This work provides material flow data and environmental concentrations of nine ENM in Denmark. It represents the first study that distinguishes between photostable TiO₂ (as used in sunscreens) and photocatalytic TiO₂ (as used in self-cleaning surfaces). It also provides first exposure estimates for quantum dots, carbon black and CuCO₃. Other ENM that are covered are ZnO, Ag, CNT and CeO₂. The modeling is based for all ENM on probability distributions of production, use, environmental release and transfer between compartments, always considering the complete life-cycle of products containing the ENM. The magnitude of flows and concentrations of the various ENM depends on the one hand on the production volume but also on the type of products they are used in and the life-cycles of these products and their potential for release. The results reveal that in aquatic systems the highest concentrations are expected for carbon black and photostable TiO₂, followed by CuCO₃ (under the assumption that the use as wood preservative becomes important). In sludge-treated soil highest concentrations are expected for CeO₂ and TiO₂. Transformation during water treatments results in extremely low concentrations of ZnO and Ag in the environment. The results of this study provide valuable environmental exposure information for future risk assessments of these ENM.

Cornea and anterior eye assessment with placido-disc keratoscopy, slit scanning evaluation topography and scheimpflug imaging tomography

PubMed Central

Martin, Raul

2018-01-01

Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple and several devices and technologies allow to explore and to manage patients. The purpose of this special issue is to present and also to update in the evaluation of cornea and ocular surface and this second part, reviews a description of the corneal topography and tomography techniques, providing updated information of the clinical recommendations of these techniques in eye care practice. Placido-based topographers started an exciting anterior corneal surface analysis that allows the development of current corneal tomographers that provide a full three-dimensional reconstruction of the cornea including elevation, curvature, and pachymetry data of anterior and posterior corneal surfaces. Although, there is not an accepted reference standard technology for corneal topography description and it is not possible to determine which device produces the most accurate topographic measurements, placido-based topographers are a valuable technology to be used in primary eye care and corneal tomograhers expanding the possibilities to explore cornea and anterior eye facilitating diagnosis and follow-up in several situations, raising patient follow-up, and improving the knowledge regarding to the corneal anatomy. Main disadvantages of placido-based topographers include the absence of information about the posterior corneal surface and limited corneal surface coverage without data from the para-central and/or peripheral corneal surface. However, corneal tomographers show repeatable anterior and posterior corneal surfaces measurements, providing full corneal thickness data improving cornea, and anterior surface assessment. However, differences between devices suggest that they are not interchangeable in clinical practice. PMID:29480244

Cornea and anterior eye assessment with placido-disc keratoscopy, slit scanning evaluation topography and scheimpflug imaging tomography.

PubMed

Martin, Raul

2018-03-01

Current corneal assessment technologies make the process of corneal evaluation extremely fast and simple and several devices and technologies allow to explore and to manage patients. The purpose of this special issue is to present and also to update in the evaluation of cornea and ocular surface and this second part, reviews a description of the corneal topography and tomography techniques, providing updated information of the clinical recommendations of these techniques in eye care practice. Placido-based topographers started an exciting anterior corneal surface analysis that allows the development of current corneal tomographers that provide a full three-dimensional reconstruction of the cornea including elevation, curvature, and pachymetry data of anterior and posterior corneal surfaces. Although, there is not an accepted reference standard technology for corneal topography description and it is not possible to determine which device produces the most accurate topographic measurements, placido-based topographers are a valuable technology to be used in primary eye care and corneal tomograhers expanding the possibilities to explore cornea and anterior eye facilitating diagnosis and follow-up in several situations, raising patient follow-up, and improving the knowledge regarding to the corneal anatomy. Main disadvantages of placido-based topographers include the absence of information about the posterior corneal surface and limited corneal surface coverage without data from the para-central and/or peripheral corneal surface. However, corneal tomographers show repeatable anterior and posterior corneal surfaces measurements, providing full corneal thickness data improving cornea, and anterior surface assessment. However, differences between devices suggest that they are not interchangeable in clinical practice.

Measuring the intangibles: a metrics for the economic complexity of countries and products.

PubMed

Cristelli, Matthieu; Gabrielli, Andrea; Tacchella, Andrea; Caldarelli, Guido; Pietronero, Luciano

2013-01-01

We investigate a recent methodology we have proposed to extract valuable information on the competitiveness of countries and complexity of products from trade data. Standard economic theories predict a high level of specialization of countries in specific industrial sectors. However, a direct analysis of the official databases of exported products by all countries shows that the actual situation is very different. Countries commonly considered as developed ones are extremely diversified, exporting a large variety of products from very simple to very complex. At the same time countries generally considered as less developed export only the products also exported by the majority of countries. This situation calls for the introduction of a non-monetary and non-income-based measure for country economy complexity which uncovers the hidden potential for development and growth. The statistical approach we present here consists of coupled non-linear maps relating the competitiveness/fitness of countries to the complexity of their products. The fixed point of this transformation defines a metrics for the fitness of countries and the complexity of products. We argue that the key point to properly extract the economic information is the non-linearity of the map which is necessary to bound the complexity of products by the fitness of the less competitive countries exporting them. We present a detailed comparison of the results of this approach directly with those of the Method of Reflections by Hidalgo and Hausmann, showing the better performance of our method and a more solid economic, scientific and consistent foundation.

Measuring the Intangibles: A Metrics for the Economic Complexity of Countries and Products

PubMed Central

Cristelli, Matthieu; Gabrielli, Andrea; Tacchella, Andrea; Caldarelli, Guido; Pietronero, Luciano

2013-01-01

We investigate a recent methodology we have proposed to extract valuable information on the competitiveness of countries and complexity of products from trade data. Standard economic theories predict a high level of specialization of countries in specific industrial sectors. However, a direct analysis of the official databases of exported products by all countries shows that the actual situation is very different. Countries commonly considered as developed ones are extremely diversified, exporting a large variety of products from very simple to very complex. At the same time countries generally considered as less developed export only the products also exported by the majority of countries. This situation calls for the introduction of a non-monetary and non-income-based measure for country economy complexity which uncovers the hidden potential for development and growth. The statistical approach we present here consists of coupled non-linear maps relating the competitiveness/fitness of countries to the complexity of their products. The fixed point of this transformation defines a metrics for the fitness of countries and the complexity of products. We argue that the key point to properly extract the economic information is the non-linearity of the map which is necessary to bound the complexity of products by the fitness of the less competitive countries exporting them. We present a detailed comparison of the results of this approach directly with those of the Method of Reflections by Hidalgo and Hausmann, showing the better performance of our method and a more solid economic, scientific and consistent foundation. PMID:23940633

Ancient bacterial endosymbionts of insects: Genomes as sources of insight and springboards for inquiry.

PubMed

Wernegreen, Jennifer J

2017-09-15

Ancient associations between insects and bacteria provide models to study intimate host-microbe interactions. Currently, a wealth of genome sequence data for long-term, obligately intracellular (primary) endosymbionts of insects reveals profound genomic consequences of this specialized bacterial lifestyle. Those consequences include severe genome reduction and extreme base compositions. This minireview highlights the utility of genome sequence data to understand how, and why, endosymbionts have been pushed to such extremes, and to illuminate the functional consequences of such extensive genome change. While the static snapshots provided by individual endosymbiont genomes are valuable, comparative analyses of multiple genomes have shed light on evolutionary mechanisms. Namely, genome comparisons have told us that selection is important in fine-tuning gene content, but at the same time, mutational pressure and genetic drift contribute to genome degradation. Examples from Blochmannia, the primary endosymbiont of the ant tribe Camponotini, illustrate the value and constraints of genome sequence data, and exemplify how genomes can serve as a springboard for further comparative and experimental inquiry. Copyright © 2017. Published by Elsevier Inc.

Telescience - Concepts And Contributions To The Extreme Ultraviolet Explorer Mission

NASA Astrophysics Data System (ADS)

Marchant, Will; Dobson, Carl; Chakrabarti, Supriya; Malina, Roger F.

1987-10-01

A goal of the telescience concept is to allow scientists to use remotely located instruments as they would in their laboratory. Another goal is to increase reliability and scientific return of these instruments. In this paper we discuss the role of transparent software tools in development, integration, and postlaunch environments to achieve hands on access to the instrument. The use of transparent tools helps to reduce the parallel development of capability and to assure that valuable pre-launch experience is not lost in the operations phase. We also discuss the use of simulation as a rapid prototyping technique. Rapid prototyping provides a cost-effective means of using an iterative approach to instrument design. By allowing inexpensive produc-tion of testbeds, scientists can quickly tune the instrument to produce the desired scientific data. Using portions of the Extreme Ultraviolet Explorer (EUVE) system, we examine some of the results of preliminary tests in the use of simulation and tran-sparent tools. Additionally, we discuss our efforts to upgrade our software "EUVE electronics" simulator to emulate a full instrument, and give the pros and cons of the simulation facilities we have developed.

Carbon nanotube transistor based high-frequency electronics

NASA Astrophysics Data System (ADS)

Schroter, Michael

At the nanoscale carbon nanotubes (CNTs) have higher carrier mobility and carrier velocity than most incumbent semiconductors. Thus CNT based field-effect transistors (FETs) are being considered as strong candidates for replacing existing MOSFETs in digital applications. In addition, the predicted high intrinsic transit frequency and the more recent finding of ways to achieve highly linear transfer characteristics have inspired investigations on analog high-frequency (HF) applications. High linearity is extremely valuable for an energy efficient usage of the frequency spectrum, particularly in mobile communications. Compared to digital applications, the much more relaxed constraints for CNT placement and lithography combined with already achieved operating frequencies of at least 10 GHz for fabricated devices make an early entry in the low GHz HF market more feasible than in large-scale digital circuits. Such a market entry would be extremely beneficial for funding the development of production CNTFET based process technology. This talk will provide an overview on the present status and feasibility of HF CNTFET technology will be given from an engineering point of view, including device modeling, experimental results, and existing roadblocks. Carbon nanotube transistor based high-frequency electronics.

Carbon nanotube transistor based high-frequency electronics

NASA Astrophysics Data System (ADS)

Schroter, Michael

At the nanoscale carbon nanotubes (CNTs) have higher carrier mobility and carrier velocity than most incumbent semiconductors. Thus CNT based field-effect transistors (FETs) are being considered as strong candidates for replacing existing MOSFETs in digital applications. In addition, the predicted high intrinsic transit frequency and the more recent finding of ways to achieve highly linear transfer characteristics have inspired investigations on analog high-frequency (HF) applications. High linearity is extremely valuable for an energy efficient usage of the frequency spectrum, particularly in mobile communications. Compared to digital applications, the much more relaxed constraints for CNT placement and lithography combined with already achieved operating frequencies of at least 10 GHz for fabricated devices make an early entry in the low GHz HF market more feasible than in large-scale digital circuits. Such a market entry would be extremely beneficial for funding the development of production CNTFET based process technology. This talk will provide an overview on the present status and feasibility of HF CNTFET technology will be given from an engineering point of view, including device modeling, experimental results, and existing roadblocks.

Proteomics of vitamin B12 processing.

PubMed

Hannibal, Luciana; DiBello, Patricia M; Jacobsen, Donald W

2013-03-01

The causes of cobalamin (B12, Cbl) deficiency are multifactorial. Whether nutritional due to poor dietary intake, or functional due to impairments in absorption or intracellular processing and trafficking events, the major symptoms of Cbl deficiency include megaloblastic anemia, neurological deterioration and in extreme cases, failure to thrive and death. The common biomarkers of Cbl deficiency (hyperhomocysteinemia and methylmalonic acidemia) are extremely valuable diagnostic indicators of the condition, but little is known about the changes that occur at the protein level. A mechanistic explanation bridging the physiological changes associated with functional B12 deficiency with its intracellular processers and carriers is lacking. In this article, we will cover the effects of B12 deficiency in a cblC-disrupted background (also referred to as MMACHC) as a model of functional Cbl deficiency. As will be shown, major protein changes involve the cytoskeleton, the neurological system as well as signaling and detoxification pathways. Supplementation of cultured MMACHC-mutant cells with hydroxocobalamin (HOCbl) failed to restore these variants to the normal phenotype, suggesting that a defective Cbl processing pathway produces irreversible changes at the protein level.

Cyanobacteria and microalgae: a renewable source of bioactive compounds and other chemicals.

PubMed

Encarnação, Telma; Pais, Alberto A C C; Campos, Maria G; Burrows, Hugh D

2015-01-01

Microalgae and cyanobacteria are rich sources of many valuable compounds, including important bioactive and biotechnologically relevant chemicals. Their enormous biodiversity, and the consequent variability in the respective biochemical composition, make microalgae cultivations a promising resource for many novel chemically and biologically active molecules and compounds of high commercial value such as lipids and dyes. The nature of the chemicals produced can be manipulated by changing the cultivation media and conditions. Algae are extremely versatile because they can be adapted to a variety of cell culture conditions. They do not require arable land, can be cultivated on saline water and wastewaters, and require much less water than plants. They possess an extremely high growth rate making these microorganisms very attractive for use in biofuel production--some species of algae can achieve around 100 times more oil than oil seeds. In addition, microalgae and cyanobacteria can accumulate various biotoxins and can contribute to mitigate greenhouse gases since they produce biomass through carbon dioxide fixation. In this review, we provide an overview of the application of microalgae in the production of bioactive and other chemicals.

Genetics Home Reference: paroxysmal extreme pain disorder

MedlinePlus

... extreme pain disorder is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which ... Page National Institute of Neurological Disorders and Stroke: Peripheral Neuropathy Information Page Educational Resources (6 links) Disease InfoSearch: ...

A simple scaling approach to produce climate scenarios of local precipitation extremes for the Netherlands

NASA Astrophysics Data System (ADS)

Lenderink, Geert; Attema, Jisk

2015-08-01

Scenarios of future changes in small scale precipitation extremes for the Netherlands are presented. These scenarios are based on a new approach whereby changes in precipitation extremes are set proportional to the change in water vapor amount near the surface as measured by the 2m dew point temperature. This simple scaling framework allows the integration of information derived from: (i) observations, (ii) a new unprecedentedly large 16 member ensemble of simulations with the regional climate model RACMO2 driven by EC-Earth, and (iii) short term integrations with a non-hydrostatic model Harmonie. Scaling constants are based on subjective weighting (expert judgement) of the three different information sources taking also into account previously published work. In all scenarios local precipitation extremes increase with warming, yet with broad uncertainty ranges expressing incomplete knowledge of how convective clouds and the atmospheric mesoscale circulation will react to climate change.

How Historical Information Can Improve Extreme Value Analysis of Coastal Water Levels

NASA Astrophysics Data System (ADS)

Le Cozannet, G.; Bulteau, T.; Idier, D.; Lambert, J.; Garcin, M.

2016-12-01

The knowledge of extreme coastal water levels is useful for coastal flooding studies or the design of coastal defences. While deriving such extremes with standard analyses using tide gauge measurements, one often needs to deal with limited effective duration of observation which can result in large statistical uncertainties. This is even truer when one faces outliers, those particularly extreme values distant from the others. In a recent work (Bulteau et al., 2015), we investigated how historical information of past events reported in archives can reduce statistical uncertainties and relativize such outlying observations. We adapted a Bayesian Markov Chain Monte Carlo method, initially developed in the hydrology field (Reis and Stedinger, 2005), to the specific case of coastal water levels. We applied this method to the site of La Rochelle (France), where the storm Xynthia in 2010 generated a water level considered so far as an outlier. Based on 30 years of tide gauge measurements and 8 historical events since 1890, the results showed a significant decrease in statistical uncertainties on return levels when historical information is used. Also, Xynthia's water level no longer appeared as an outlier and we could have reasonably predicted the annual exceedance probability of that level beforehand (predictive probability for 2010 based on data until the end of 2009 of the same order of magnitude as the standard estimative probability using data until the end of 2010). Such results illustrate the usefulness of historical information in extreme value analyses of coastal water levels, as well as the relevance of the proposed method to integrate heterogeneous data in such analyses.

A UK medical devices regulator's perspective on registries.

PubMed

Wilkinson, John; Crosbie, Andy

2016-04-01

Registries are powerful tools to support manufacturers in the fulfilment of their obligations to perform post-market surveillance and post-market clinical follow-up of implantable medical devices. They are also a valuable resource for regulators in support of regulatory action as well as in providing information around the safety of new and innovative technologies. Registries can provide valuable information on the relative performance of both generic types and manufacturer's individual products and they complement other sources of information about device performance such as post-market clinical studies and adverse incident reporting. This paper describes the experience of the UK medical device regulator - the Medicines and Healthcare Products Regulatory Agency (MHRA) - of working with registries to monitor the safety and performance of medical devices. Based upon this experience, the authors identify a number of attributes for a registry which they consider to be key if the registry is to contribute effectively to the work of regulators on patient safety monitoring and medical device regulation.

Information based universal feature extraction

NASA Astrophysics Data System (ADS)

Amiri, Mohammad; Brause, Rüdiger

2015-02-01

In many real world image based pattern recognition tasks, the extraction and usage of task-relevant features are the most crucial part of the diagnosis. In the standard approach, they mostly remain task-specific, although humans who perform such a task always use the same image features, trained in early childhood. It seems that universal feature sets exist, but they are not yet systematically found. In our contribution, we tried to find those universal image feature sets that are valuable for most image related tasks. In our approach, we trained a neural network by natural and non-natural images of objects and background, using a Shannon information-based algorithm and learning constraints. The goal was to extract those features that give the most valuable information for classification of visual objects hand-written digits. This will give a good start and performance increase for all other image learning tasks, implementing a transfer learning approach. As result, in our case we found that we could indeed extract features which are valid in all three kinds of tasks.

Image-Based 3d Reconstruction Data as AN Analysis and Documentation Tool for Architects: the Case of Plaka Bridge in Greece

NASA Astrophysics Data System (ADS)

Kouimtzoglou, T.; Stathopoulou, E. K.; Agrafiotis, P.; Georgopoulos, A.

2017-02-01

Μodern advances in the field of image-based 3D reconstruction of complex architectures are valuable tools that may offer the researchers great possibilities integrating the use of such procedures in their studies. In the same way that photogrammetry was a well-known useful tool among the cultural heritage community for years, the state of the art reconstruction techniques generate complete and easy to use 3D data, thus enabling engineers, architects and other cultural heritage experts to approach their case studies in an exhaustive and efficient way. The generated data can be a valuable and accurate basis upon which further plans and studies will be drafted. These and other aspects of the use of image-based 3D data for architectural studies are to be presented and analysed in this paper, based on the experience gained from a specific case study, the Plaka Bridge. This historic structure is of particular interest, as it was recently lost due to extreme weather conditions and serves as a strong proof that preventive actions are of utmost importance in order to preserve our common past.

Hydrometeorological extremes and their impacts derived from taxation records for south-eastern Moravia (Czech Republic) in the period 1751-1900

NASA Astrophysics Data System (ADS)

Chromá, K.; Brázdil, R.; Valášek, H.; Dolák, L.

2012-04-01

Hydrometeorological extremes always influenced human activities and caused great material damage or even loss of human lives. In the Czech Lands (recently the Czech Republic), systematic meteorological and hydrological observations started generally in the latter half of the 19th century. In order to create long-term series of hydrometeorological extremes, it is necessary to search for other sources of information for their study before 1850. In this study, written records associated with tax relief at ten estates located in south-eastern Moravia are used for the study of hydrometeorological extremes and their impacts during the period 1751-1900. The taxation system in Moravia allowed farmers to request tax relief if their crop yields had been negatively affected by hydrological and meteorological extremes. The documentation involved contains information about the type of extreme event and the date of its occurrence, and the impacts on crops may often be derived. A total of 175 extreme events resulting in some kind of damage is documented for 1751-1900, with the highest concentration between 1811 and 1860. The nature of events leading to damage (of a possible 272 types) include hailstorm (25.7%), torrential rain (21.7%), and flood (21.0%), followed by thunderstorm, flash flood, late frost and windstorm. The four most outstanding events, affecting the highest number of settlements, were thunderstorms with hailstorms (25 June 1825, 20 May 1847 and 29 June 1890) and flooding of the River Morava (mid-June 1847). Hydrometeorological extremes in the 1816-1855 period are compared with those occurring during the recent 1961-2000 period. The results obtained are inevitably influenced by uncertainties related to taxation records, such as their temporal and spatial incompleteness, the limits of the period of outside agricultural work (i.e. mainly May-August) and the purpose for which they were originally collected (primarily tax alleviation, i.e. information about hydrometeorological extremes was of secondary importance). Taxation records represent an important source of data for historical climatology and historical hydrology and have a great potential for use.

Rethinking Intelligence to Integrate Counterterrorism into the Local Law Enforcement Mission

DTIC Science & Technology

2007-03-01

a needle in the haystack problem. Also referred to as the wheat versus the chaff problem, valuable information must be separated from unimportant...information and processed before analysts can yield any useful intelligence.25 3. Processing and Exploitation To address the wheat -versus-chaff...93 Despite the perception that Chicago is an aging Rust Belt city, some experts report that it has the largest high technology and information

Does a Formal Wiki Event Contribute to the Formation of a Network of Practice? A Social Capital Perspective on the Potential for Informal Learning

ERIC Educational Resources Information Center

Rehm, Martin; Littlejohn, Allison; Rienties, Bart

2018-01-01

Informal learning in blended and online settings plays an increasingly important role in the continuous professional development of individuals. Yet, how do individuals engage into these types of activities? We argue that social capital theory can provide valuable insights into how people behave and decide to take part in (in)formal learning.…

Public Health System Response to Extreme Weather Events.

PubMed

Hunter, Mark D; Hunter, Jennifer C; Yang, Jane E; Crawley, Adam W; Aragón, Tomás J

2016-01-01

Extreme weather events, unpredictable and often far-reaching, constitute a persistent challenge for public health preparedness. The goal of this research is to inform public health systems improvement through examination of extreme weather events, comparing across cases to identify recurring patterns in event and response characteristics. Structured telephone-based interviews were conducted with representatives from health departments to assess characteristics of recent extreme weather events and agencies' responses. Response activities were assessed using the Centers for Disease Control and Prevention Public Health Emergency Preparedness Capabilities framework. Challenges that are typical of this response environment are reported. Forty-five local health departments in 20 US states. Respondents described public health system responses to 45 events involving tornadoes, flooding, wildfires, winter weather, hurricanes, and other storms. Events of similar scale were infrequent for a majority (62%) of the communities involved; disruption to critical infrastructure was universal. Public Health Emergency Preparedness Capabilities considered most essential involved environmental health investigations, mass care and sheltering, surveillance and epidemiology, information sharing, and public information and warning. Unanticipated response activities or operational constraints were common. We characterize extreme weather events as a "quadruple threat" because (1) direct threats to population health are accompanied by damage to public health protective and community infrastructure, (2) event characteristics often impose novel and pervasive burdens on communities, (3) responses rely on critical infrastructures whose failure both creates new burdens and diminishes response capacity, and (4) their infrequency and scale further compromise response capacity. Given the challenges associated with extreme weather events, we suggest opportunities for organizational learning and preparedness improvements.

Project X: competitive intelligence data mining and analysis

NASA Astrophysics Data System (ADS)

Gilmore, John F.; Pagels, Michael A.; Palk, Justin

2001-03-01

Competitive Intelligence (CI) is a systematic and ethical program for gathering and analyzing information about your competitors' activities and general business trends to further your own company's goals. CI allows companies to gather extensive information on their competitors and to analyze what the competition is doing in order to maintain or gain a competitive edge. In commercial business this potentially translates into millions of dollars in annual savings or losses. The Internet provides an overwhelming portal of information for CI analysis. The problem is how a company can automate the translation of voluminous information into valuable and actionable knowledge. This paper describes Project X, an agent-based data mining system specifically developed for extracting and analyzing competitive information from the Internet. Project X gathers CI information from a variety of sources including online newspapers, corporate websites, industry sector reporting sites, speech archiving sites, video news casts, stock news sites, weather sites, and rumor sites. It uses individual industry specific (e.g., pharmaceutical, financial, aerospace, etc.) commercial sector ontologies to form the knowledge filtering and discovery structures/content required to filter and identify valuable competitive knowledge. Project X is described in detail and an example competitive intelligence case is shown demonstrating the system's performance and utility for business intelligence.

Hydrometeorological extremes at the Veselí nad Moravou estate (Czech Republic) in the period 1794-1850 derived from documentary evidence of the economic character

NASA Astrophysics Data System (ADS)

Chromá, Kateřina

2010-05-01

Hydrometeorological extremes influenced always human activities (agriculture, forestry, water management) and caused losses of human lives and great material damage. Systematic meteorological and hydrological observations in the Czech Lands (recent Czech Republic) started generally in the latter half of the 19th century. In order to create long-term series of hydrometeorological extremes, it is necessary to search for other sources of information for their study before 1850. Such direct and indirect information about hydrometeorological extremes is included in documentary evidence (e.g. chronicles, memoirs, diaries, early visual weather observations, newspapers, economic sources etc.). Documentary evidence of economic character belongs to the most important sources, especially documents related to taxation records. Damage to agricultural crops on the fields or damage to hay on meadows due to the hydrological and meteorological phenomena has been a good reason for the abatement of tax duty. Based on the official correspondence of the estate of Veselí nad Moravou (southern Moravia), archival information about taxation from the Moravian Land Archives in Brno was excerpted. Based on it, 46 hydrometeorological extremes which occurred between the years 1794 and 1850 were selected and further analysed. Because of fields and meadows of the above estate were located along the Morava River, reports of damage due to floods were the most frequent, followed by damage due to torrential rains and hailstorms.

Bayesian species delimitation in Pleophylla chafers (Coleoptera) - the importance of prior choice and morphology.

PubMed

Eberle, Jonas; Warnock, Rachel C M; Ahrens, Dirk

2016-05-05

Defining species units can be challenging, especially during the earliest stages of speciation, when phylogenetic inference and delimitation methods may be compromised by incomplete lineage sorting (ILS) or secondary gene flow. Integrative approaches to taxonomy, which combine molecular and morphological evidence, have the potential to be valuable in such cases. In this study we investigated the South African scarab beetle genus Pleophylla using data collected from 110 individuals of eight putative morphospecies. The dataset included four molecular markers (cox1, 16S, rrnL, ITS1) and morphometric data based on male genital morphology. We applied a suite of molecular and morphological approaches to species delimitation, and implemented a novel Bayesian approach in the software iBPP, which enables continuous morphological trait and molecular data to be combined. Traditional morphology-based species assignments were supported quantitatively by morphometric analyses of the male genitalia (eigenshape analysis, CVA, LDA). While the ITS1-based delineation was also broadly congruent with the morphospecies, the cox1 data resulted in over-splitting (GMYC modelling, haplotype networks, PTP, ABGD). In the most extreme case morphospecies shared identical haplotypes, which may be attributable to ILS based on statistical tests performed using the software JML. We found the strongest support for putative morphospecies based on phylogenetic evidence using the combined approach implemented in iBPP. However, support for putative species was sensitive to the use of alternative guide trees and alternative combinations of priors on the population size (θ) and rootage (τ 0 ) parameters, especially when the analysis was based on molecular or morphological data alone. We demonstrate that continuous morphological trait data can be extremely valuable in assessing competing hypotheses to species delimitation. In particular, we show that the inclusion of morphological data in an integrative Bayesian framework can improve the resolution of inferred species units. However, we also demonstrate that this approach is extremely sensitive to guide tree and prior parameter choice. These parameters should be chosen with caution - if possible - based on independent empirical evidence, or careful sensitivity analyses should be performed to assess the robustness of results. Young species provide exemplars for investigating the mechanisms of speciation and for assessing the performance of tools used to delimit species on the basis of molecular and/or morphological evidence.

The limits for life under multiple extremes.

PubMed

Harrison, Jesse P; Gheeraert, Nicolas; Tsigelnitskiy, Dmitry; Cockell, Charles S

2013-04-01

Life on Earth is limited by physical and chemical extremes that define the 'habitable space' within which it operates. Aside from its requirement for liquid water, no definite limits have been established for life under any extreme. Here, we employ growth data published for 67 prokaryotic strains to explore the limitations for microbial life under combined extremes of temperature, pH, salt (NaCl) concentrations, and pressure. Our review reveals a fundamental lack of information on the tolerance of microorganisms to multiple extremes that impedes several areas of science, ranging from environmental and industrial microbiology to the search for extraterrestrial life. Copyright © 2013 Elsevier Ltd. All rights reserved.

Porting Extremely Lightweight Intrusion Detection (ELIDe) to Android

DTIC Science & Technology

2015-10-01

ARL-TN-0681 ● OCT 2015 US Army Research Laboratory Porting Extremely Lightweight Intrusion Detection (ELIDe) to Android by...Lightweight Intrusion Detection (ELIDe) to Android by Ken F Yu and Garret S Payer Computational and Information Sciences Directorate, ARL...

Shallow-water brittle stars (Echinodermata: Ophiuroidea) from Araçá Bay (Southeastern Brazil), with spatial distribution considerations.

PubMed

Alitto, Renata A S; Bueno, Maristela L; Guilherme, Pablo D B; Di Domenico, Maikon; Christensen, Ana Beardsley; Borges, Michela

2018-04-05

The detailed study of arm ossicles, particularly the lateral arm plates, is providing valuable information in the elucidation of ophiuroid taxonomy. The present study describes in detail 16 species of brittle stars from Araçá Bay, Brazil. This information is used to construct the first interactive electronic key, providing a valuable resource for a broad range of researchers. Brittle stars families were divided into three groups based on their spatial distribution: i) infaunal species of intertidal and shallow subtidal belonging to Amphiuridae and Ophiactidae, ii) epizoic species belonging to Amphiuridae, Ophiactidae, and Ophiotrichidae and, iii) epifaunal species of the subtidal belonging to Ophiodermatidae and Hemieuryalidae. In the global context of recent revisions of ophiuroid taxonomy, the present work provides additional characters for use in future phylogenetic studies.

Fine resolution probabilistic land cover classification of landscapes in the southeastern United States

Treesearch

Joseph St. Peter; John Hogland; Nathaniel Anderson; Jason Drake; Paul Medley

2018-01-01

Land cover classification provides valuable information for prioritizing management and conservation operations across large landscapes. Current regional scale land cover geospatial products within the United States have a spatial resolution that is too coarse to provide the necessary information for operations at the local and project scales. This paper describes a...

Tapping into Alumni as a Source of Authentic Information and Advice on Careers in Psychology

ERIC Educational Resources Information Center

Lawson, Timothy J.

2018-01-01

This article describes how my psychology department utilizes our alumni to educate current and prospective students about careers in psychology. I explain how we developed an alumni careers website and on-campus alumni careers sessions for students. High school students and our psychology majors reported that they found this information valuable,…