F-region neutral winds from ionosonde measurements of h/sub mF2/ at low-latitude magnetic conjugate regions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bittencourt, J.A.

1977-08-01

The behavior of the F2-peak height difference, delta h/sub F2/, between low-latitude magnetic conjugate points, is known to be governed by thermospheric winds blowing along the magnetic meridian. Ground-based ionosonde measurement of h/sub m F2/, at two pairs of magnetic conjugate stations, were analyzed in conjunction with the results of a realistic dynamic computer model of the tropical ionospheric F-region, to determine thermospheric wind velocities. The behavior of monthly average values of the sun, at conjugate points, of the thermospheric horizontal wind velocity component in the magnetic meridian, at low latitudes, is inferred for months of solstice and equinox, asmore » well as for periods of low and high solar activity.« less

Plasma Drift Rates During and Preceding Equatorial Spread F Inferred by the HF Doppler Technique

NASA Astrophysics Data System (ADS)

Miller, E. S.; Hilton, A. J.; Chartier, A.

2017-12-01

The quiet time afternoon and evening equatorial and low-latitude ionosphere is characterized by increasing vertical drift and sharpening plasma density gradient in the lower F region. This combination of effects leads to the plasma instability cascade known imprecisely as "equatorial spread F." In this work, we utilize a simple transequatorial HF Doppler observation to infer the vertical and horizontal plasma drifts preceding and during spread-F conditions. The data exhibit three behavior regimes indicative of three different processes: The first is a slow vertical drift that may be due to either increasing vertical plasma drifts or recombination of the bottomside. The second is an explosive spread Doppler signature (indicating relative velocities of 600 m/s or more) that is associated with the initiation of the spread-F depletions. Finally, the third is a structure that represents a changing HF propagation channel as radio rays propagate through the regions of depleted-but still unstable-plasma. Observations of the March 2016 Pacific total solar eclipse will also be included as a test case for the effects of vertical drifts versus recombination.

Photoelectron energy loss and spectral features deduced by the plasma line technique. [in topside F region

NASA Technical Reports Server (NTRS)

Abreu, V. J.; Carlson, H. C.

1977-01-01

Plasma line data gathered at the Arecibo Observatory are used to examine relative variations in topside F region differential photoelectron fluxes in the 5- to 20-eV range. A spectral feature not found in present theoretically calculated spectra is noted near 15 eV. A new approach to the interpretation of the measured spectra is taken, which allows a qualitative estimate of the relative importance of different energy loss mechanisms. The altitude variation of the observed photoelectron flux energy spectra at the higher altitudes (above 350 km) and the lower energies (less than 10 eV) agrees quantitatively with the expected variation of the spectrum.

C_7F_16/He rf plasma CVD of a-C:F films

NASA Astrophysics Data System (ADS)

Hokoi, Kohji; Akazawa, Masamichi; Sugawara, Hirotake; Sakai, Yosuke

2000-10-01

Fluorinated carbon is one of the most promissing materials with low dielectric constant ɛr and high dielectric strength V_b. We have deposited a-C:F films by rf (13.56 MHz) plasma enhanced CVD method using the following liquid materials; C_7F_16, (C_3F_7)_3N/(C_4F_9)_3N and C_8F_18/C_8F_16O.(C. P. Lungu et al.), Jpn. J. Appl. Phys. 38, L1544--6 (1999) The films showed ɛr values in a range of 1.9--3.0 and V_b>2 MV/cm. In this work, we added He (3 Pa) to C_7F_16 (60 Pa) plasmas, expecting that He atoms in the metastable excited state (He*, 19.8 eV) would promote C_7F_16 decomposition in gas phase or activation of the film surface during deposition. The films with the thickness up to 2300 nm were deposited on unheated Si substrate with an rf power of 100 W. The deposition rate derived from the film thickness measurement by SEM and ellipsometry was about 230 nm/min. This value is roughly two times as large as that of the films deposited by C_7F_16 (60 Pa) plasmas without He. We discuss the mechanism that leads to such a significant increase in the deposition rate.

Pre-storm NmF2 enhancements at middle latitudes: delusion or reality?

NASA Astrophysics Data System (ADS)

Mikhailov, A. V.; Perrone, L.

2009-03-01

A critical analysis of recent publications devoted to the NmF2 pre-storm enhancements is performed. There are no convincing arguments that the observed cases of NmF2 enhancements at middle and sub-auroral latitudes bear a relation to the following magnetic storms. In all cases considered the NmF2 pre-storm enhancements were due to previous geomagnetic storms, moderate auroral activity or they presented the class of positive quiet time events (Q-disturbances). Therefore, it is possible to conclude that there is no such an effect as the pre-storm NmF2 enhancement as a phenomenon inalienably related to the following magnetic storm. The observed nighttime NmF2 enhancements at sub-auroral latitudes may result from plasma transfer from the plasma ring area by meridional thermospheric wind. Enhanced plasmaspheric fluxes into the nighttime F2-region resulted from westward substorm-associated electric fields is another possible source of nighttime NmF2 enhancements. Daytime positive Q-disturbances occurring under very low geomagnetic activity level may be related to the dayside cusp activity.

VLF and HF Plasma Waves Associated with Spread-F Plasma Depletions Observed on the C/NOFS Satellite

NASA Technical Reports Server (NTRS)

Pfaff, Robert; Freudenreich, H.; Schuck, P.; Klenzing, J.

2011-01-01

The C/NOFS spacecraft frequently encounters structured plasma depletions associated with equatorial spread-F along its trajectory that varies between 401 km perigee and 867 km apogee in the low latitude ionosphere. We report two classes of plasma waves detected with the Vector Electric Field Investigation (VEFI) that appear when the plasma frequency is less than the electron gyro frequency, as is common in spread-F depletions where the plasma number density typically decreases below 10(exp 4)/cu cm. In these conditions, both broadband VLF waves with a clear cutoff at the lower hybrid frequency and broadband HF waves with a clear cutoff at the plasma frequency are observed. We interpret these waves as "hiss-type" emissions possibly associated with the flow of suprathermal electrons within the inter-hemispherical magnetic flux tubes. We also report evidence of enhanced wave "transients" sometimes embedded in the broader band emissions that are associated with lightning sferics detected within the depleted plasma regions that appear in both the VLF and HF data. Theoretical implications of these observations are discussed.

Distribution of Region 1 and 2 currents in the quietand substorm time plasma sheetfrom THEMIS observations

NASA Astrophysics Data System (ADS)

Liu, J.; Angelopoulos, V.; Chu, X.; McPherron, R. L.

2016-12-01

Although Earth's Region 1 and 2 currents are related to activities such as substorm initiation, their magnetospheric origin remains unclear. Utilizing the triangular configuration of THEMIS probes at 8-12 RE downtail, we seek the origin of nightside Region 1 and 2 currents. The triangular configuration allows a curlometer-like technique which do not rely on active-time boundary crossings, so we can examine the current distribution in quiet times as well as active times. Our statistical study reveals that both Region 1 and 2 currents exist in the plasma sheet during quiet and active times. Especially, this is the first unequivocal, in-situ evidence of the existence of Region 2 currents in the plasma sheet. Farther away from the neutral sheet than the Region 2 currents lie the Region 1 currents which extend at least to the plasma sheet boundary layer. At geomagnetic quiet times, the separation between the two currents is located 2.5 RE from the neutral sheet. These findings suggest that the plasma sheet is a source of Region 1 and 2 currents regardless of geomagnetic activity level. During substorms, the separation between Region 1 and 2 currents migrates toward (away from) the neutral sheet as the plasma sheet thins (thickens). This migration indicates that the deformation of Region 1 and 2 currents is associated with redistribution of FAC sources in the magnetotail. In some substorms when the THEMIS probes encounter a dipolarization, a substorm current wedge (SCW) can be inferred from our technique, and it shows a distinctively larger current density than the pre-existing Region 1 currents. This difference suggests that the SCW is not just an enhancement of the pre-existing Region 1 current; the SCW and the Region 1 currents have different sources.

Decomposed Fragment Identification in C_8F_18 RF Plasma for a-C:F Film Production

NASA Astrophysics Data System (ADS)

Sakai, Yosuke; Tazawa, Shota; Bratescu, Maria; Suda, Yoshiyuki; Sugawara, Hirotake

2004-09-01

Amorphous fluorocarbon polymer (a-C:F) film shows excellent insulation properties such as low dielectric constant (<2.5), high dielectric strength (>2 MV/cm), low surface energy, and chemical inertness. Therefore, we have studied this film for a purpose of an additional insulator to enhance the breakdown voltage in an alternative to a SF6 gas insulation system. The films are prepared using a C_8F_18 vapor RF plasma. When per-fluorocarbon, such as C_8F_18 as source gases, then the deposition rate becomes roughly two orders of magnitude higher than that obtained from conventional low molecular-weight source monomers (CF_4, C_2F_6, C_3F_6, and C_4F_8) [1]. The breakdown voltage (V_s) of N_2, Ar and He gases between the a-C:F film coated Al sphere-sphere electrodes for a gas pressure (p) times gap length (d), pd=0.1-100 Torr¥cm, was studied as well. Then, Vs between the a-C:F film coated electrodes was a several times higher than that between the Al electrodes in the present pd range[2]. In this work, the decomposed species of C_8F_18 in the plasma were identified using emission spectra from the plasma and Quadra-pole mass spectrograph, and the reason why the high deposition rate was obtained was discussed. The physical and chemical properties of a-C:F film was analyzed. [1] C.P.Lungu, et.al., Jpn. J. Appl. Phys. 38 (12B) L1544 - L1546 (1999) [2] C.Biloiu, et.al., Jpn. J. Appl. Phys. 42 (2B) L 201- L203 (2003) Work supported by Grant-in-Aid for Scientific Research (B), JSPS.

Anti-adhesive characteristics of CHF{sub 3}/O{sub 2} and C{sub 4}F{sub 8}/O{sub 2} plasma-modified silicon molds for nanoimprint lithography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Jaemin; Lee, Junmyung; Lee, Hyun Woo

The anti-adhesive characteristics of a plasma-modified silicon mold surface for nanoimprint lithography are presented. Both CHF{sub 3}/O{sub 2} and C{sub 4}F{sub 8}/O{sub 2} plasma were used to form an anti-adhesive layer on silicon mold surfaces. The gas mixing ratios of CHF{sub 3}/O{sub 2} and C{sub 4}F{sub 8}/O{sub 2} were experimentally changed between 0% and 80% to optimize the plasma conditions to obtain a low surface energy of the silicon mold. The plasma characteristics were examined by optical emission spectroscopy (OES). In order to investigate the changes in surface energy and surface chemistry of the anti-adhesive layer during repeated demolding cycles,more » contact angle measurements and X-ray photoelectron spectroscopy (XPS) were performed on the plasma-modified silicon mold surface. Simultaneously, the surface morphology of the demolded resists was evaluated by field-emission scanning electron microscope (FE-SEM) in order to examine the effect of the anti-adhesive layers on the duplicated patterns of the resists. It was observed that the anti-adhesive layer formed by CHF{sub 3}/O{sub 2} plasma treatment was worn out more easily during repeated demolding cycles than the film formed by C{sub 4}F{sub 8}/O{sub 2} plasma treatment, because CHF{sub 3}/O{sub 2} gas plasma formed a thinner plasma-polymerized film over the same plasma treatment time.« less

Plasma 8-iso-Prostaglandin F2α, a possible prognostic marker in aneurysmal subarachnoid hemorrhage.

PubMed

Pan, De-Sheng; Yan, Min; Hassan, Muhammad; Fang, Ze-Bin; Chen, Man-Tao

2017-06-01

8-iso-Prostaglandin F2α (8-iso-PGF2α) is a potential biomarker of oxidative stress. This study clarified whether plasma 8-iso-PGF2α concentrations were affected and its underlying relevance to prognosis in aneurysmal subarachnoid hemorrhage (aSAH). In this prospective, observational study, a total of 170 controls and 170 aSAH patients were enrolled. Plasma 8-iso-PGF2α concentrations were detected using an ELISA. Severity was assessed by World Federation of Neurological Surgeons (WFNS) scale and modified Fisher grading scale. Clinical outcomes included 6-month mortality and poor outcome referred to as Glasgow outcome scale score of 1-3. As compared to controls, admission plasma 8-iso-PGF2α concentrations were significantly enhanced. Increased concentrations of plasma 8-iso-PGF2α correlated with WFNS scores and modified Fisher scores. 8-iso-PGF2α in plasma was an independent predictor for clinical outcomes. Under ROC curve, the predictive values of 8-iso-PGF2α concentrations resembled those of WFNS scores and modified Fisher scores for clinical outcomes. An elevation in plasma 8-iso-PGF2α concentrations is associated with the severity and poor outcome after aSAH, substantializing 8-iso-PGF2α as a potential prognostic biomarker of aSAH. Copyright © 2017. Published by Elsevier B.V.

Increased F3-Isoprostanes in the Canadian Inuit Population Could Be Cardioprotective by Limiting F2-Isoprostane Production.

PubMed

Alkazemi, Dalal; Jackson, Robert L; Chan, Hing Man; Kubow, Stan

2016-09-01

F3-isoprostanes (F3-IsoPs), derived from peroxidation of eicosapentaenoic acid (C20:5n-3), could be cardioprotective by limiting production of F2-isoprostanes (F2-IsoPs), a cardiovascular disease risk factor. The objective of the study was to determine whether the n-3-polyunsaturated (PUFA)-rich Inuit diet is associated with a lower plasma ratio of F2-IsoPs to F3-IsoPs. This was a cross-sectional observational study. The study was conducted in 36 Canadian Arctic Inuit communities. Participants included a random subset (n = 233) of Inuit adults taken from a population-based survey. Plasma F2-IsoPs and F3-IsoPs, cardiometabolic risk factors (blood lipids, C-reactive protein, blood pressure, fasting glucose) and markers of dietary exposure (erythrocyte n-3 and n-6 PUFA, blood levels of Se, mercury, polychlorinated biphenyls) were measured. Inuit aged 40 years old and older vs younger Inuit showed higher concentrations of plasma F3-IsoPs and erythrocyte n-3 PUFA and lower plasma F2-IsoPs concentrations despite having higher blood lipids, fasting glucose, systolic blood pressure, and percentage body fat. Plasma F3-IsoPs were not associated with any cardiometabolic measures. When subjects were categorized into tertiles according to total n-3 PUFA erythrocyte concentrations, F3-IsoPs increased with increasing tertiles, whereas the F2-IsoP to F3-IsoP ratio was lowest at the highest n-3 tertile. The F2-IsoP to F3-IsoP ratio was significantly predicted by C20:5n-3 (β= -.365, P = .002); C20:4n-6:C20:5n-3 (β = .056, P = .006), blood mercury (β = -.812, P =.015), blood Se (β = -1.95, P = .015), and smoking (β = .745, P = .025). Plasma F3-IsoPs were not associated with cardiometabolic risk factors previously seen with F2-IsoPs. Higher n-3 fatty acid status was associated with lower plasma F2-IsoPs and higher plasma F3-IsoPs, which provides partial explanation to the cardioprotective effects of the n-3 PUFA-rich Inuit diet.

Volatile organic compounds emission control in industrial pollution source using plasma technology coupled with F-TiO2/γ-Al2O3.

PubMed

Zhu, Tao; Chen, Rui; Xia, Ni; Li, Xiaoyang; He, Xianxian; Zhao, Wenjuan; Carr, Tim

2015-01-01

Volatile organic compounds' (VOCs) effluents, which come from many industries, are triggering serious environmental problems. As an emerging technology, non-thermal plasma (NTP) technology is a potential technology for VOCs emission control. NTP coupled with F-TiO2/γ-Al2O3 is used for toluene removal from a gaseous influent at normal temperature and atmospheric pressure. NTP is generated by dielectric barrier discharge, and F-TiO2/γ-Al2O3 can be prepared by sol-gel method in the laboratory. In the experiment, the different packed materials were packed into the plasma reactor, including γ-Al2O3, TiO2/γ-Al2O3 and F-TiO2/γ-Al2O3. Through a series of characterization methods such as X-ray diffraction, scanning electronic microscopy and Brunner-Emmet-Teller measurements, the results show that the particle size distribution of F-TiO2 is relatively smaller than that of TiO2, and the pore distribution of F-TiO2 is more uniformly distributed than that of TiO2. The relationships among toluene removal efficiency, reactor input energy density, and the equivalent capacitances of air gap and dielectric barrier layer were investigated. The results show that the synergistic technology NTP with F-TiO2/γ-Al2O3 resulted in greater enhancement of toluene removal efficiency and energy efficiency. Especially, when packing with F-TiO2/γ-Al2O3 in NTP reactor, toluene removal efficiency reaches 99% and higher. Based on the data analysis of Fourier Transform Infrared Spectroscopy, the experimental results showed that NTP reactor packed with F-TiO2/γ-Al2O3 resulted in a better inhibition for by-products formation effectively in the gas exhaust.

Clinical significance of plasma apolipoprotein F in Japanese healthy and hypertriglyceridemic subjects.

PubMed

Kujiraoka, Takeshi; Nakamoto, Takaaki; Sugimura, Hiroyuki; Iwasaki, Tadao; Ishihara, Mitsuaki; Hoshi, Toshiyasu; Horie, Yasuto; Ogawa, Kazuyuki; Todoroki, Masakatsu; Nakatani, Yuki; Banba, Nobuyuki; Yasu, Takanori; Hattori, Hiroaki

2013-01-01

Apolipoprotein F (apo F), also known as lipid transfer inhibitory protein (LTIP), is a protein component of plasma lipoprotein classes including HDL and functions to inhibit lipid transfer between lipoproteins in vitro. To study the role of plasma apo F, a reliable and sensitive tool for the quantification would be needed. We have developed a sandwich ELISA using two monoclonal antibodies for human plasma apo F, and analyzed apo F concentration in 397 Japanese healthy and 221 hypertriglyceridemic subjects. Our ELISA enables apo F to be assayed in the range of 0.6-25 µg/mL with intra- and inter-assay coefficients of variation less than 3.8% and 7.8%, respectively. In healthy subjects, plasma apo F concentration was 12.5±2.9 µg/mL (mean±SD), and was significantly higher in females than in males (p<0.05). By linear regression analysis in healthy subjects, plasma apo F concentration correlated positively with HDL cholesterol and apo A-I levels, and in males but not in females, negatively with apo B and triglyceride levels. It also correlated negatively with intrinsic CETP activity measured using intrinsic apo B-containing lipoprotein as an acceptor, and positively with PLTP mass and apo J levels. Apo F concentration in hypertriglyceridemic patients (10.3±3.1 µg/mL) was lower than in healthy controls (p<0.0001) and correlated positively with PLTP mass. Our ELISA is reliable and sensitive for the quantification of plasma apo F concentration. This system can be applicable for clinical significance in lipoprotein metabolism and reverse cholesterol transport.

High-affinity dopamine D2/D3 PET radioligands 18F-fallypride and 11C-FLB457: A comparison of kinetics in extrastriatal regions using a multiple-injection protocol

PubMed Central

Vandehey, Nicholas T; Moirano, Jeffrey M; Converse, Alexander K; Holden, James E; Mukherjee, Jogesh; Murali, Dhanabalan; Nickles, R Jerry; Davidson, Richard J; Schneider, Mary L; Christian, Bradley T

2010-01-01

18F-Fallypride and 11C-FLB457 are commonly used PET radioligands for imaging extrastriatal dopamine D2/D3 receptors, but differences in their in vivo kinetics may affect the sensitivity for measuring subtle changes in receptor binding. Focusing on regions of low binding, a direct comparison of the kinetics of 18F-fallypride and 11C-FLB457 was made using a MI protocol. Injection protocols were designed to estimate K1, k2, fNDkon, Bmax, and koff in the midbrain and cortical regions of the rhesus monkey. 11C-FLB457 cleared from the arterial plasma faster and yielded a ND space distribution volume (K1/k2) that is three times higher than 18F-fallypride, primarily due to a slower k2 (FAL:FLB; k2=0.54 min−1:0.18 min−1). The dissociation rate constant, koff, was slower for 11C-FLB457, resulting in a lower KDapp than 18F-fallypride (FAL:FLB; 0.39 nM:0.13 nM). Specific D2/D3 binding could be detected in the cerebellum for 11C-FLB457 but not 18F-fallypride. Both radioligands can be used to image extrastriatal D2/D3 receptors, with 11C-FLB457 providing greater sensitivity to subtle changes in low-receptor-density cortical regions and 18F-fallypride being more sensitive to endogenous dopamine displacement in medium-to-high-receptor-density regions. In the presence of specific D2/D3 binding in the cerebellum, reference region analysis methods will give a greater bias in BPND with 11C-FLB457 than with 18F-fallypride. PMID:20040928

Analysis of laser produced plasmas of gold in the 1-7 nm region

NASA Astrophysics Data System (ADS)

Li, Bowen; Higashiguchi, Takeshi; Otsuka, Takamitsu; Yugami, Noboru; Dunne, Padraig; Kilbane, Deirdre; Sokell, Emma; O'Sullivan, Gerry

2014-04-01

Extreme ultraviolet (EUV) spectra from gold laser produced plasmas were recorded in the 1-7 nm region using two Nd:YAG lasers with pulse lengths of 150 ps and 10 ns, respectively, operating at a range of power densities. The maximum focused peak power density was 9.5 × 1013 W cm-2 for the former and 5.3 × 1012 W cm-2 for the latter. Two intense quasicontinuous intensity bands resulting from n = 4-n = 4 and n = 4-n = 5 unresolved transition arrays dominate the 4-5.5 and 1.5-3.6 nm regions of both spectra. Comparison with atomic structure calculations performed with the Cowan suite of atomic structure codes as well as consideration of previous experimental and theoretical results aided identification of the most prominent features in the spectra. For the ns spectrum, the highest ion stage that could be identified from the n = 4-n = 5 arrays was Au28+ while for the ps plasma the presence of significantly higher stages was deduced and lines due to 4d104f-4d94f2 transitions in Ag-like Au32+ give rise to the strongest observed features within the n = 4-n = 4 array while in the n = 4-n = 5 array it was possible to identify a number of previously unidentified spectral features as resulting from 4f-5g transitions in the spectra of Au XX to Au XXXIII.

Morphology of ionospheric F2 region variability associated with sudden stratospheric warmings

NASA Astrophysics Data System (ADS)

Gupta, Sumedha; Upadhayaya, A. K.

2017-07-01

The effect of sudden stratospheric warming (SSW) on the F2 region ionosphere has been extensively analyzed for the major event of year 2009, apart from a few reports on other major and minor events. Morphology of ionospheric responses during SSW can be better comprehended by analyzing such warming events under different solar, geomagnetic, and meteorological conditions. We investigate the features of F2 region variability following the SSW events of 2010, 2011, 2012, 2013, 2014, 2015, and 2016, using ionosonde data from the Asian region covering a broad latitudinal range from 26.6°N to 45.1°N. We find perceptible ionospheric variations in electron densities during these warming events which is accompanied by a large variation of 117% within enhancements, as compared to a meagre variation of 11% within depressions, during these events. We also examine 6 months data at these latitudes and longitudes and find that the maximum and minimum variations in F2 layer critical frequency are observed during each SSW period. The influence of quasi-stationary 16 day planetary waves is seen during these SSW events. Further, a recently proposed parameter "SSW integrated strength" by Vieira et al. (2017) to characterize SSW event with respect to ionosphere is also examined. It is seen that it does not fit well for these seven SSW events at these latitudes and longitudes.

Observation of F region irregularities near a northern equatorial anomaly crest during solar minimum using ionosonde, GPS receiver, and satellites

NASA Astrophysics Data System (ADS)

Lee, C.-C.; Chen, W. S.; Chu, F. D.

2013-06-01

For solar minimum, the spread F, GPS phase fluctuations, and plasma bubbles near the crest of equatorial ionization anomaly (EIA) are simultaneously analyzed to investigate F region irregularities for the first time. The data were observed using the Chungli ionosonde, YMSM GPS receiver, and DMSP satellites during 1996. It is found that in the observed ionograms, the frequency spread F (FSF) usually comes after the range spread F (RSF) in a series of nighttime spread F events. This results in that the maximum occurrence of RSF appears before that of FSF in the nighttime variations in occurrence probabilities. Moreover, the seasonal variation for RSF is close to that for FSF. Both have a board maximum in the J-months and a secondary maximum in December. These indicate that RSF and FSF should be regarded as one type of spread F, which is the all spread F (ASF) in this study. Because the equatorial plasma bubbles occur infrequently during solar minimum, the F region irregularities forming ASF are not related to the equatorial spread F. On the other hand, the similarity in seasonal occurrence between ASF and medium-scale traveling ionospheric disturbances (MSTIDs) demonstrates that the F region irregularities near the EIA crest are mainly generated by the gradient drift instability driven by MSTIDs. The irregularities, generated by MSTIDs, mostly occur in the bottom side of the F region. Consequently, the events of significant GPS phase fluctuations and plasma bubble near the EIA crest are rare during 1996.

Disturbance dynamo effects over low-latitude F region: A study by network of VHF spaced receivers

NASA Astrophysics Data System (ADS)

Kakad, B.; Surve, G.; Tiwari, P.; Yadav, V.; Bhattacharyya, A.

2017-05-01

Generation of equatorial spread F (ESF) irregularities resulting from magnetic disturbance is known for past few decades. However, better prediction models for this phenomenon are still lacking. Magnetic storms also affects the F region plasma drifts. In this work we examined variability in (i) occurrence of such freshly generated ESF and (ii) low-latitude F region zonal plasma drifts over Indian longitude. For this purpose simultaneous observations of amplitude scintillations on 251 MHz signal, recorded by a network of spaced receivers located at low-latitude stations, are utilized. Observational stations are situated such that it longitudinally (latitudinally) covers an area of 5.6° (13°). Here effect of disturbance dynamo (DD) electric field at low-latitude F region and its variability are studied for three magnetic storms occurring in 2011. These magnetic storms are having nearly similar type characteristics except their start time. We find that as time difference (i.e., ΔT) between local sunset and start of magnetic activity decreases, the DD effects seen at low-latitude F region zonal irregularity drift around midnight becomes stronger. For a given magnetic storm the DD effect on F region zonal irregularity drifts is found to be only marginally stronger at dip equator in comparison to off-equatorial stations. Although effect of DD on F region zonal irregularity drifts are felt simultaneously, generation of fresh ESF is variable within a smaller longitudinal belt of 5.6°. It is attributed to the presence of LSWS at the bottomside of F region, as initiation of ESF is highly likely (unlikely) in the vicinity of crest (trough) of such LSWS.

Modeling of Tracer Transport Delays for Improved Quantification of Regional Pulmonary 18F-FDG Kinetics, Vascular Transit Times, and Perfusion

PubMed Central

Wellman, Tyler J.; Winkler, Tilo; Vidal Melo, Marcos F.

2015-01-01

18F-FDG-PET is increasingly used to assess pulmonary inflammatory cell activity. However, current models of pulmonary 18F-FDG kinetics do not account for delays in 18F-FDG transport between the plasma sampling site and the lungs. We developed a three-compartment model of 18F-FDG kinetics that includes a delay between the right heart and the local capillary blood pool, and used this model to estimate regional pulmonary perfusion. We acquired dynamic 18F-FDG scans in 12 mechanically ventilated sheep divided into control and lung injury groups (n=6 each). The model was fit to tracer kinetics in three isogravitational regions-of-interest to estimate regional lung transport delays and regional perfusion. 13NN bolus infusion scans were acquired during a period of apnea to measure regional perfusion using an established reference method. The delayed input function model improved description of 18F-FDG kinetics (lower Akaike Information Criterion) in 98% of studied regions. Local transport delays ranged from 2.0–13.6s, averaging 6.4±2.9s, and were highest in non-dependent regions. Estimates of regional perfusion derived from model parameters were highly correlated with perfusion measurements based on 13NN-PET (R2=0.92, p<0.001). By incorporating local vascular transports delays, this model of pulmonary 18F-FDG kinetics allows for simultaneous assessment of regional lung perfusion, transit times, and inflammation. PMID:25940652

Spectroscopy Study of Ar + CO2 Plasmas in ASTRAL.

NASA Astrophysics Data System (ADS)

Munoz, Jorge; Boivin, Robert; Kamar, Ola; Loch, Stuart; Ballance, Connor

2006-10-01

A spectroscopy study of the ASTRAL (Auburn Steady sTate Research fAciLity) helicon plasma source running Ar + CO2 gas mix is presented. ASTRAL produces Ar plasmas: ne = 10^10 to 10^13 cm-3, Te = 2 to 10 eV and Ti = 0.03 to 0.5 eV. A series of 7 large coils produce an axial magnetic field up to 1.3 kGauss. A fractional helix antenna is used to introduce rf power up to 2 kWatt. A spectrometer which features a 0.33 m Criss-Cross monochromator and a CCD camera is used for this study. Very different plasmas are produced following the relative importance of CO2 in the gas mixture. At low CO2 concentration, the plasmas are similar to those obtained with pure Ar with weak CO2, CO2^+, CO and CO^+ bands. The usual blue plasma core associated with intense Ar II transitions is observed with however a significant white glow coming from the outer plasma regions. At higher CO2 concentration, the plasma becomes essentially molecular and can be described as an intense white plasma column. Molecular dissociative processes associated with the production of strong C and O atomic lines are observed under specific plasma conditions. The atomic spectral lines are compared with ADAS modeling results. This study indicates the possible advantages of using a helicon source to control the CO2 plasma chemistry for industrial applications.

In-situ studies of plasma irregularities in high latitude ionosphere with the ICI-2 sounding rocket within the 4DSpace project

NASA Astrophysics Data System (ADS)

Miloch, Wojciech; Moen, Joran; Spicher, Andres

Ionospheric plasma is often characterized by irregularities, instabilities, and turbulence. Two regions of the ionospheric F-layer are of particular interest: low-latitudes for the equatorial anomaly and electrojet, and high-latitude regions where the most dynamic phenomena occur due to magnetic field lines coupling to the magnetosphere and the solar wind. The spectra of plasma fluctuations in the low-latitude F-layer usually exhibit a power law with a steeper slope at high frequencies [1]. Until recently, there was no clear evidence of the corresponding double slope spectra for plasma fluctuations in the high latitude ionospheric F-layer, and this difference was not well understood. We report the first direct observations of the double slope power spectra for plasma irregularities in the F-layer of the polar ionosphere [2]. The ICI-2 sounding rocket, which intersected enhanced plasma density regions with decameter scale irregularities in the cusp region, measured the electron density with unprecedented high resolution. This allowed for a detailed study of the plasma irregularities down to kinetic scales. Spectral analysis reveals double slope power spectra for regions of enhanced fluctuations associated mainly with density gradients, with the steepening of the spectra occurring close to the oxygen gyro-frequency. The double slope spectra are further supported by the results from the ICI-3 sounding rocket. Double slope spectra were not resolved in previous works presumably due to limited resolution of instruments. The study is a part of the 4DSpace initiative for integrated studies of the ionospheric plasma turbulence with multi-point, multi-scale in-situ studies by sounding rockets and satellites, and numerical and analytical models. A brief overview of the 4DSpace initiative is given. [1] M.C. Kelley, The Earth’s Ionosphere Plasma Physics and Electrodynamics (Elsevier, Amsterdam 2009). [2] A. Spicher, W. J. Miloch, and J. I. Moen, Geophys. Res. Lett. 40, (in

Auroral E-region Plasma Irregularities and their Control by the Plasma Convection in the Southern Hemisphere

NASA Astrophysics Data System (ADS)

Forsythe, V. V.; Makarevich, R. A.

2016-12-01

Small-scale ionospheric plasma irregularities in the high-latitude E region and their control by F-region plasma convection are investigated using Super Dual Auroral Network (SuperDARN) observations at high southern latitudes over a 1-year period. Significant asymmetries are found in the velocity occurrence distribution due to the clustering of the high-velocity echoes of a particular velocity polarity. Statistical analysis of convection showed that some radars observe predominantly negative bias in the convection component within their short, E-region ranges, while others have a predominantly positive bias. A hypothesis that this bias is caused by asymmetric sectoring of the high-latitude plasma convection pattern is investigated. A new algorithm is developed that samples the plasma convection map and evaluates the convection pattern asymmetry along the particular latitude that corresponds to the radar location. It is demonstrated that the convection asymmetry has a particular seasonal and diurnal pattern, which is different for the polar and auroral radars. Possible causes for the observed convection pattern asymmetry are discussed. It is further proposed that the statistical occurrence of high-velocity E-region echoes generated by the Farley-Buneman instability (FBI) is highly sensitive to small changes in the convection pattern, which is consistent with the electric field threshold for the FBI onset being perhaps sharper and lower than previously thought.

Effect of the chamber wall on fluorocarbon-assisted atomic layer etching of SiO2 using cyclic Ar/C4F8 plasma

PubMed Central

Kawakami, Masatoshi; Metzler, Dominik; Li, Chen; Oehrlein, Gottlieb S.

2016-01-01

The authors studied the effect of the temperature and chemical state of the chamber wall on process performance for atomic layer etching of SiO2 using a steady-state Ar plasma, periodic injection of a defined number of C4F8 molecules, and synchronized plasma-based Ar+ ion bombardment. To evaluate these effects, the authors measured the quartz coupling window temperature. The plasma gas phase chemistry was characterized using optical emission spectroscopy. It was found that although the thickness of the polymer film deposited in each cycle is constant, the etching behavior changed, which is likely related to a change in the plasma gas phase chemistry. The authors found that the main gas phase changes occur after C4F8 injection. The C4F8 and the quartz window react and generate SiF and CO. The emission intensity changes with wall surface state and temperature. Therefore, changes in the plasma gas species generation can lead to a shift in etching performance during processing. During initial cycles, minimal etching is observed, while etching gradually increases with cycle number. PMID:27375342

F2 region response to geomagnetic disturbances across Indian latitudes: O(1S) dayglow emission

NASA Astrophysics Data System (ADS)

Upadhayaya, A. K.; Gupta, Sumedha; Brahmanandam, P. S.

2016-03-01

The morphology of ionospheric storms has been investigated across equatorial and low latitudes of Indian region. The deviation in F2 region characteristic parameters (foF2 and h'F) along with modeled green line dayglow emission intensities is examined at equatorial station Thiruvananthapuram (8.5°N, 76.8°E, 0.63°S geomagnetic latitude) and low-latitude station Delhi (28.6°N, 77.2°E,19.2°N geomagnetic latitude) during five geomagnetic storm events. Both positive and negative phases have been noticed in this study. The positive storm phase over equatorial station is found to be more frequent, while the drop in ionization in most of the cases was observed at low-latitude station. It is concluded that the reaction as seen at different ionospheric stations may be quite different during the same storm depending on both the geographic and geomagnetic coordinates of the station, storm intensity, and the storm onset time. Modulation in the F2 layer critical frequency at low and equatorial stations during geomagnetic disturbance of 20-23 November 2003 was caused by the storm-induced changes in O/N2. It is also found that International Reference Ionosphere 2012 model predicts the F2 layer characteristic (foF2 and h'F) parameters at both the low and equatorial stations during disturbed days quite reasonably. A simulative approach in GLOW model developed by Solomon is further used to estimate the changes in the volume emission rate of green line dayglow emission under quiet and strong geomagnetic conditions. It is found that the O(1S) dayglow thermospheric emission peak responds to varying geomagnetic conditions.

Measurements of Electron Density Profiles of Plasmas Produced by Nike KrF Laser for Laser Plasma Instability (LPI) Research

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Obenschain, S. P.; Schmitt, A. J.; Kehne, D. M.; Karasik, M.; Chan, L.-Y.; Serlin, V.; Phillips, L.

2013-10-01

Knowing spatial profiles of electron density (ne) in the underdense coronal region (n plasma is essential to understanding LPI initiation in inertial confinement fusion research. In the recent Nike LPI experiment, a side-on grid imaging refractometer (GIR) was deployed for measuring the underdense plasma profiles. Plasmas were produced from flat CH targets illuminated by Nike KrF laser with total energies up to 1 kJ of 0.5 ~ 1 nsec FWHM pulses. The GIR resolved ne up to 3 ×1021 /cm3 in space taking 2D snapshot images of probe laser (λ = 263 nm, Δt = 10 ps) beamlets (50 μm spacing) refracted by the plasma at a selected time during the laser illumination. The individual beamlet transmittances were also measured for Te estimation. Time-resolved spectrometers with an absolute-intensity-calibrated photodiode array and a streak camera simultaneously detected light emission from the plasma in spectral ranges relevant to Raman (SRS) and two plasmon decay instabilities. The measured spatial profiles are compared with simulation results from the FAST3D radiation hydrocode and their effects on the LPI observations are investigated. Work supported by DoE/NNSA and performed at Naval Research Laboratory.

Modeling of Tracer Transport Delays for Improved Quantification of Regional Pulmonary ¹⁸F-FDG Kinetics, Vascular Transit Times, and Perfusion.

PubMed

Wellman, Tyler J; Winkler, Tilo; Vidal Melo, Marcos F

2015-11-01

¹⁸F-FDG-PET is increasingly used to assess pulmonary inflammatory cell activity. However, current models of pulmonary ¹⁸F-FDG kinetics do not account for delays in ¹⁸F-FDG transport between the plasma sampling site and the lungs. We developed a three-compartment model of ¹⁸F-FDG kinetics that includes a delay between the right heart and the local capillary blood pool, and used this model to estimate regional pulmonary perfusion. We acquired dynamic ¹⁸F-FDG scans in 12 mechanically ventilated sheep divided into control and lung injury groups (n = 6 each). The model was fit to tracer kinetics in three isogravitational regions-of-interest to estimate regional lung transport delays and regional perfusion. ¹³NN bolus infusion scans were acquired during a period of apnea to measure regional perfusion using an established reference method. The delayed input function model improved description of ¹⁸F-FDG kinetics (lower Akaike Information Criterion) in 98% of studied regions. Local transport delays ranged from 2.0 to 13.6 s, averaging 6.4 ± 2.9 s, and were highest in non-dependent regions. Estimates of regional perfusion derived from model parameters were highly correlated with perfusion measurements based on ¹³NN-PET (R² = 0.92, p < 0.001). By incorporating local vascular transports delays, this model of pulmonary ¹⁸F-FDG kinetics allows for simultaneous assessment of regional lung perfusion, transit times, and inflammation.

Features of the Electromagnetic and Plasma Disturbances Induced at the Altitudes of the Earth's Outer Ionosphere by Modification of the Ionospheric F 2 Region Using High-Power Radio Waves Radiated by the SURA Heating Facility

NASA Astrophysics Data System (ADS)

Frolov, V. L.; Rapoport, V. O.; Schorokhova, E. A.; Belov, A. S.; Parrot, M.; Rauch, J.-L.

2016-08-01

In this paper we systematize the results of studying the characteristics of the plasma-density ducts, which was conducted in 2005-2010 during the DEMETER-satellite operation. The ducts are formed at altitudes of about 700 km as a result of the ionospheric F 2 region modification by high-power high-frequency radio waves radiated by the midlatitude SURA heating facility. All the performed measurements are used as the basis for determining the formation conditions for such ducts, the duct characteristics are studied, and the opportunities for the duct influence on the ionosphere-magnetosphere coupling and propagation of radio waves of various frequency ranges are demonstrated. The results of numerical simulation of the formation of such ducts are presented.

Measurements of Electron Temperature and Density Profiles of Plasmas Produced by Nike KrF Laser for Laser Plasma Instability (LPI) Research

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Obenschain, S. P.; Schmitt, A. J.; Kehne, D. M.; Karasik, M.; Chan, L.-Y.; Serlin, V.; Phillips, L.

2012-10-01

ExperimentsfootnotetextJ. Oh, et al, GO5.4, APS DPP (2010).^,footnotetextJ. L. Weaver, et al, GO5.3, APS DPP (2010). using Nike KrF laser observed LPI signatures from CH plasmas at the laser intensities above ˜1x10^15 W/cm^2. Knowing spatial profiles of temperature (Te) and density (ne) in the underdense coronal region (0 < n < nc/4) of the plasma is essential to understanding the LPI observation. However, numerical simulation was the only way to access the profiles for the previous experiments. In the current Nike LPI experiment, a side-on grid imaging refractometer (GIR)footnotetextR. S. Craxton, et al, Phys. Fluids B 5, 4419 (1993). is being deployed for measuring the underdense plasma profiles. The GIR will resolve Te and ne in space taking a 2D snapshot of probe laser (λ= 263 nm, δt = 10 psec) beamlets (50μm spacing) refracted by the plasma at a selected time during the laser illumination. Time-resolved spectrometers with an absolute-intensity-calibrated photodiode array and a streak camera will simultaneously monitor light emission from the plasma in spectral ranges relevant to Raman (SRS) and two plasmon decay (TDP) instabilities. The experimental study of effects of the plasma profiles on the LPI initiation will be presented.

Relationship between ionospheric plasma bubble occurrence and lightning strikes over the Amazon region

NASA Astrophysics Data System (ADS)

Sousasantos, Jonas; Sobral, José Humberto Andrade; Alam Kherani, Esfhan; Magalhães Fares Saba, Marcelo; Rodolfo de Campos, Diovane

2018-03-01

The vertical coupling between the troposphere and the ionosphere presents some remarkable features. Under intense tropospheric convection, gravity waves may be generated, and once they reach the ionosphere, these waves may seed instabilities and spread F and equatorial plasma bubble events may take place. Additionally, there is a close association between severe tropospheric convection and lightning strikes. In this work an investigation covering an equinox period (September-October) during the deep solar minimum (2009) presents the relation between lightning strike activity and spread F (equatorial plasma bubble) detected over a low-latitude Brazilian region. The results show a considerable correlation between these two phenomena. The common element in the center of this conformity seems to be the gravity waves. Once gravity waves and lightning strikes share the same source (intense tropospheric convection) and the effects of such gravity waves in the ionosphere include the seeding of instabilities according to the gravity waves magnitude, the monitoring of the lightning strike activity seems to offer some information about the subsequent development of spread F over the equatorial region.

Plasma flow in peripheral region of detached plasma in linear plasma device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayashi, Y., E-mail: hayashi-yuki13@ees.nagoya-u.ac.jp; Ohno, N.; Kajita, S.

2016-01-15

A plasma flow structure is investigated using a Mach probe under detached plasma condition in a linear plasma device NAGDIS-II. A reverse flow along the magnetic field is observed in a steady-state at far-peripheral region of the plasma column in the upstream side from the recombination front. These experimental results indicate that plasma near the recombination front should strongly diffuse across the magnetic field, and it should be transported along the magnetic field in the reverse flow direction. Furthermore, bursty plasma density fluctuations associated with intermittent convective plasma transport are observed in the far-peripheral region of the plasma column inmore » both upstream and downstream sides from the recombination front. Such a nondiffusive transport can contribute to the intermittent reverse plasma flow, and the experimental results indicate that intermittent transports are frequently produced near the recombination front.« less

Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages.

PubMed

Nagasawa, Masahiro; Nakagawa, Yuko; Tanaka, Shigeyasu; Kojima, Itaru

2007-03-01

The present study was conducted to characterize the regulation and function of TRPV2 in macrophages. Among six members of the TRPV family channels, only the expression of TRPV2 was detected in macrophages. We then determined localization of TRPV2 using TtT/M87 macrophages transfected with TRPV2-EGFP. In serum-free condition, most of the TRPV2 signal was located in the cytoplasm and colocalized with the endoplasmic reticulum marker. Treatment with serum induced translocation of some of the TRPV2-EGFP to the plasma membrane. Serum-induced translocation was blocked by transfection of short-form TRPV2 (s-TRPV2) lacking a pore-forming region and the sixth transmembrane domain. Addition of a chemotactic peptide formyl Met-Leu-Phe (fMLP) also induced translocation of TRPV2-EGFP to the plasma membrane. The fMLP-induced translocation was blocked by an inhibitor of PI 3-kinase, LY294002, and pertussis toxin. Whole-cell patch clamp analysis showed a Cs+ current in the TtT/M87 cell, which was blocked by an addition of ruthenium red and transfection of either s-TRPV2 or siRNA for TRPV2. fMLP increased the Cs+ current. fMLP induced a rapid and sustained elevation of cytoplasmic Ca2+ ([Ca2+]C), the sustained phase of which was abolished by removal of extracellular calcium. The sustained elevation of [Ca2+]C was also blocked by ruthenium red, and transfection of either s-TRPV2 or siRNA. Finally, fMLP-induced migration of macrophage was blocked by ruthenium red or transfection of s-TRPV2. These results suggest that fMLP induces translocation of TRPV2 from intracellular compartment to the plasma membrane, and this translocation is critical for fMLP-induced calcium entry. Copyright 2006 Wiley-Liss, Inc.

Ionospheric research. [E region, F region, D region

NASA Technical Reports Server (NTRS)

1975-01-01

Progress is reported in the following areas: D-region theory; E and F-region; wave propagation; mass spectrometer measurements; and atmospheric reactions. Various supporting operations are included: design and construction of instrumentation; and programming.

Modeling polar cap F-region patches using time varying convection

NASA Technical Reports Server (NTRS)

Sojka, J. J.; Bowline, M. D.; Schunk, R. W.; Decker, D. T.; Valladares, C. E.; Sheehan, R.; Anderson, D. N.; Heelis, R. A.

1993-01-01

Creation of polar cap F-region patches are simulated for the first time using two independent physical models of the high latitude ionosphere. The patch formation is achieved by temporally varying the magnetospheric electric field (ionospheric convection) input to the models. The imposed convection variations are comparable to changes in the convection that result from changes in the B(y) IMF component for southward IMF. Solar maximum-winter simulations show that simple changes in the convection pattern lead to significant changes in the polar cap plasma structuring. Specifically, in winter, as enhanced dayside plasma convects into the polar cap to form the classic tongue-of-ionization the convection changes produce density structures that are indistinguishable from the observed patches.

Measurement and analysis of x-ray absorption in Al and MgF2 plasmas heated by Z-pinch radiation.

PubMed

Rochau, Gregory A; Bailey, J E; Macfarlane, J J

2005-12-01

High-power Z pinches on Sandia National Laboratories' Z facility can be used in a variety of experiments to radiatively heat samples placed some distance away from the Z-pinch plasma. In such experiments, the heating radiation spectrum is influenced by both the Z-pinch emission and the re-emission of radiation from the high-Z surfaces that make up the Z-pinch diode. To test the understanding of the amplitude and spectral distribution of the heating radiation, thin foils containing both Al and MgF2 were heated by a 100-130 TW Z pinch. The heating of these samples was studied through the ionization distribution in each material as measured by x-ray absorption spectra. The resulting plasma conditions are inferred from a least-squares comparison between the measured spectra and calculations of the Al and Mg 1s-->2p absorption over a large range of temperatures and densities. These plasma conditions are then compared to radiation-hydrodynamics simulations of the sample dynamics and are found to agree within 1sigma to the best-fit conditions. This agreement indicates that both the driving radiation spectrum and the heating of the Al and MgF2 samples is understood within the accuracy of the spectroscopic method.

Two novel nonlinear optical carbonates in the deep-ultraviolet region: KBeCO3F and RbAlCO3F2

PubMed Central

Kang, Lei; Lin, Zheshuai; Qin, Jingui; Chen, Chuangtian

2013-01-01

With the rapid developments of the all-solid-state deep-ultraviolet (deep-UV) lasers, the good nonlinear optical (NLO) crystal applied in this spectral region is currently lacking. Here, we design two novel NLO carbonates KBeCO3F and RbAlCO3F2 from the first-principles theory implemented in the molecular engineering expert system especially for NLO crystals. Both structurally stable crystals possess very large energy band gaps and optical anisotropy, so they would become the very promising deep-UV NLO crystals alternative to KBBF. Recent experimental results on MNCO3F (M = K, Rb, Cs; N = Ca, Sr, Ba) not only confirm our calculations, but also suggest that the synthesis of the KBeCO3F and RbAlCO3F2 crystals is feasible. PMID:23455618

Electrostatic Fluxes and Plasma Rotation in the Edge Region of EXTRAP-T2R

NASA Astrophysics Data System (ADS)

Serianni, G.; Antoni, V.; Bergsåker, H.; Brunsell, P.; Drake, J. R.; Spolaore, M.; Sätherblom, H. E.; Vianello, N.

2001-10-01

The EXTRAP-T2 reversed field pinch has undergone a significant reconstruction into the new T2R device. This paper reports the first measurements performed with Langmuir probes in the edge region of EXTRAP-T2R. The radial profiles of plasma parameters like electron density and temperature, plasma potential, electrical fields and electrostatic turbulence-driven particle flux are presented. These profiles are interpreted in a momentum balance model where finite Larmor radius losses occur over a distance of about two Larmor radii from the limiter position. The double shear layer of the E×B drift velocity is discussed in terms of the Biglari-Diamond-Terry theory of turbulence decorrelation.

A Conserved Region in the F2 Subunit of Paramyxovirus Fusion Proteins Is Involved In Fusion Regulation▿

PubMed Central

Gardner, Amanda E.; Dutch, Rebecca E.

2007-01-01

Paramyxoviruses utilize both an attachment protein and a fusion (F) protein to drive virus-cell and cell-cell fusion. F exists functionally as a trimer of two disulfide-linked subunits: F1 and F2. Alignment and analysis of a set of paramyxovirus F protein sequences identified three conserved blocks (CB): one in the fusion peptide/heptad repeat A domain, known to play important roles in fusion promotion, one in the region between the heptad repeats of F1 (CBF1) (A. E. Gardner, K. L. Martin, and R. E. Dutch, Biochemistry 46:5094-5105, 2007), and one in the F2 subunit (CBF2). To analyze the functions of CBF2, alanine substitutions at conserved positions were created in both the simian virus 5 (SV5) and Hendra virus F proteins. A number of the CBF2 mutations resulted in folding and expression defects. However, the CBF2 mutants that were properly expressed and trafficked had altered fusion promotion activity. The Hendra virus CBF2 Y79A and P89A mutants showed significantly decreased levels of fusion, whereas the SV5 CBF2 I49A mutant exhibited greatly increased cell-cell fusion relative to that for wild-type F. Additional substitutions at SV5 F I49 suggest that both side chain volume and hydrophobicity at this position are important in the folding of the metastable, prefusion state and the subsequent triggering of membrane fusion. The recently published prefusogenic structure of parainfluenza virus 5/SV5 F (H. S. Yin et al., Nature 439:38-44, 2006) places CBF2 in direct contact with heptad repeat A. Our data therefore indicate that this conserved region plays a critical role in stabilizing the prefusion state, likely through interactions with heptad repeat A, and in triggering membrane fusion. PMID:17507474

Stochastic Lagrangian dynamics for charged flows in the E-F regions of ionosphere

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang Wenbo; Mahalov, Alex

2013-03-15

We develop a three-dimensional numerical model for the E-F region ionosphere and study the Lagrangian dynamics for plasma flows in this region. Our interest rests on the charge-neutral interactions and the statistics associated with stochastic Lagrangian motion. In particular, we examine the organizing mixing patterns for plasma flows due to polarized gravity wave excitations in the neutral field, using Lagrangian coherent structures (LCS). LCS objectively depict the flow topology-the extracted attractors indicate generation of ionospheric density gradients, due to accumulation of plasma. Using Lagrangian measures such as the finite-time Lyapunov exponents, we locate the Lagrangian skeletons for mixing in plasma,more » hence where charged fronts are expected to appear. With polarized neutral wind, we find that the corresponding plasma velocity is also polarized. Moreover, the polarized velocity alone, coupled with stochastic Lagrangian motion, may give rise to polarized density fronts in plasma. Statistics of these trajectories indicate high level of non-Gaussianity. This includes clear signatures of variance, skewness, and kurtosis of displacements taking polarized structures aligned with the gravity waves, and being anisotropic.« less

Quantitative trait loci that control plasma lipid levels in an F2 intercross between C57BL/6J and DDD.Cg-A(y) inbred mouse strains.

PubMed

Suto, Jun-ichi

2012-04-01

The objectives of this study were to characterize plasma lipid phenotypes and dissect the genetic basis of plasma lipid levels in an obese DDD.Cg-A(y) mouse strain. Plasma triglyceride (TG) levels were significantly higher in the DDD.Cg-A(y) strain than in the B6.Cg-A(y) strain. In contrast, plasma total-cholesterol (CHO) levels did not substantially differ between the two strains. As a rule, the A(y) allele significantly increased TG levels, but did not increase CHO levels. Quantitative trait locus (QTL) analyses for plasma TG and CHO levels were performed in two types of F(2) female mice [F(2)A(y) (F(2) mice carrying the A(y) allele) and F(2) non- A(y) mice (F(2) mice without the A(y) allele)] produced by crossing C57BL/6J females and DDD.Cg-A(y) males. Single QTL scan identified one significant QTL for TG levels on chromosome 1, and two significant QTLs for CHO levels on chromosomes 1 and 8. When the marker nearest to the QTL on chromosome 1 was used as covariates, four additional significant QTLs for CHO levels were identified on chromosomes 5, 6, and 17 (two loci). In contrast, consideration of the agouti locus genotype as covariates did not detect additional QTLs. DDD.Cg-A(y) showed a low CHO level, although it had Apoa2(b), which was a CHO-increasing allele at the Apoa2 locus. This may have been partly due to the presence of multiple QTLs, which were associated with decreased CHO levels, on chromosome 8.

Wide band antireflective coatings Al2O3 / HfO2 / MgF2 for UV region

NASA Astrophysics Data System (ADS)

Winkowski, P.; Marszałek, Konstanty W.

2013-07-01

Deposition technology of the three layers antireflective coatings consists of hafnium compound are presented in this paper. Oxide films were deposited by means of e-gun evaporation in vacuum of 5x10-5 mbar in presence of oxygen and fluoride films by thermal evaporation. Substrate temperature was 250°C. Coatings were deposited onto optical lenses made from quartz glass (Corning HPFS). Thickness and deposition rate were controlled by thickness measuring system Inficon XTC/2. Simulations leading to optimization of thickness and experimental results of optical measurements carried during and after deposition process were presented. Physical thickness measurements were made during deposition process and were equal to 43 nm/74 nm/51 nm for Al2O3 / HfO2 / MgF2 respectively. Optimization was carried out for ultraviolet region from 230nm to the beginning of visible region 400 nm. In this region the average reflectance of the antireflective coating was less than 0.5% in the whole range of application.

African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels.

PubMed

Annor, Francis; Goodman, Michael; Thyagarajan, Bharat; Okosun, Ike; Doumatey, Ayo; Gower, Barbara A; Il'yasova, Dora

2017-01-01

Context . Low levels of systemic F 2 -isoprostanes (F 2 -IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F 2 -IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective . To examine differences in plasma F 2 -IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design . Cross-sectional study. Setting . Georgia residents recruited from church communities. Participants . 218 males and females 25-74 years of age, who are self-identified as NHW ( n = 83), AA ( n = 56), or WAI ( n = 79). Main Outcome Measure(s) . Plasma F 2 -IsoPs quantified by gas chromatography-mass spectrometry. Results . After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F 2 -IsoP than AA (beta-coefficient = -9.8, p < 0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p < 0.001). Similarly, among healthy nonobese participants, F 2 -IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion . Plasma F 2 -IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F 2 -IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.

N,N-dimethyl-2-(2-amino-4-(18)F-fluorophenylthio)-benzylamine (4-(18)F-ADAM): an improved PET radioligand for serotonin transporters.

PubMed

Shiue, Grace G; Choi, Seok-Rye; Fang, Ping; Hou, Catherine; Acton, Paul D; Cardi, Chris; Saffer, Janet R; Greenberg, Joel H; Karp, Joel S; Kung, Hank F; Shiue, Chyng-Yann

2003-12-01

rat brain (>96% of radioactivity was recovered as parent compound at 1 h after injection). However, it metabolized rapidly in the blood. Less than 7% of the radioactivity recovered from plasma was the parent compound, with the majority of radioactivity in the plasma not extractable by ethyl acetate. Blocking studies showed significant decreases in the uptake of 4-(18)F-ADAM in the brain regions (hypothalamus, hippocampus, and striatum) where SERT concentrations are high when rats were pretreated with (+)McN5652 (2 mg/kg 5 min before intravenous injection of 4-(18)F-ADAM). However, changes in the uptake of 4-(18)F-ADAM in these brain regions were less significant when rats were pretreated with either methylphenidate or nisoxetine. The baboon study showed that uptake of 4-(18)F-ADAM in the midbrain peaked at approximately 1 h after injection and then declined slowly. The ratios of the radioactivity in the midbrain to that in the cerebellum (where the concentration of SERT is low) at 2 and 3 h after injection were 3.2 and 4.2, respectively. 4-(18)F-ADAM is suitable as a PET radioligand for studying SERT in the living brain. Further characterization of this new radioligand in humans is warranted.

E and F region study of the evening sector auroral oval - A Chatanika/Dynamics Explorer 2/NOAA 6 comparison

NASA Technical Reports Server (NTRS)

Senior, C.; Sharber, J. R.; Winningham, J. D.; De La Beaujardiere, O.; Heelis, R. A.; Evans, D. S.; Sugiura, M.; Hoegy, W. R.

1987-01-01

Simultaneous data from the Chatanika radar and the DE 2 and NOAA 6 satellites are used to study the typical behavior of the winter evening-sector auroral plasma during moderate and steady magnetic activity. The equatorward edge of the auroral E layer, of the region 2 field-aligned currents, and of the region of intense convection are colocated. The auroral E layer extends several degrees south of the equatorward edge of the keV electron precipitation from the CPS. Although the main trough and ionization channel are embedded in a region of intense electric field where the plasma flows sunward at high speed, the flux tubes associated with these two features have different time histories. The midlatitude trough is located south of the region of electron precipitation, above a proton aurora. The ionization channel marks the poleward edge of the main trough and is colocated with the equatorward boundary of the electron precipitation from the central plasma sheet.

Laser plasma instability experiments with KrF lasersa)

NASA Astrophysics Data System (ADS)

Weaver, J. L.; Oh, J.; Afeyan, B.; Phillips, L.; Seely, J.; Feldman, U.; Brown, C.; Karasik, M.; Serlin, V.; Aglitskiy, Y.; Mostovych, A. N.; Holland, G.; Obenschain, S.; Chan, L.-Y.; Kehne, D.; Lehmberg, R. H.; Schmitt, A. J.; Colombant, D.; Velikovich, A.

2007-05-01

Deleterious effects of laser-plasma instability (LPI) may limit the maximum laser irradiation that can be used for inertial confinement fusion. The short wavelength (248nm), large bandwidth, and very uniform illumination available with krypton-fluoride (KrF) lasers should increase the maximum usable intensity by suppressing LPI. The concomitant increase in ablation pressure would allow implosion of low-aspect-ratio pellets to ignition with substantial gain (>20) at much reduced laser energy. The proposed KrF-laser-based Fusion Test Facility (FTF) would exploit this strategy to achieve significant fusion power (150MW) with a rep-rate system that has a per pulse laser energy well below 1 MJ. Measurements of LPI using the Nike KrF laser are presented at and above intensities needed for the FTF (I˜2×1015W/cm2). The results to date indicate that LPI is indeed suppressed. With overlapped beam intensity above the planar, single beam intensity threshold for the two-plasmon decay instability, no evidence of instability was observed via measurements of 3/2ωo and 1/2ωo harmonic emissions.

Vacuum ultraviolet thin films. I - Optical constants of BaF2, CaF2, LaF3, MgF2, Al2O3, HfO2, and SiO2 thin films. II - Vacuum ultraviolet all-dielectric narrowband filters

NASA Technical Reports Server (NTRS)

Zukic, Muamer; Torr, Douglas G.; Spann, James F.; Torr, Marsha R.

1990-01-01

An iteration process matching calculated and measured reflectance and transmittance values in the 120-230 nm VUV region is presently used to ascertain the optical constants of bulk MgF2, as well as films of BaF2, CaF2, LaF3, MgF2, Al2O3, HfO2, and SiO2 deposited on MgF2 substrates. In the second part of this work, a design concept is demonstrated for two filters, employing rapidly changing extinction coefficients, centered at 135 nm for BaF2 and 141 nm for SiO2. These filters are shown to yield excellent narrowband spectral performance in combination with narrowband reflection filters.

Measurement of droplet size distribution in core region of high-speed spray by micro-probe L2F

NASA Astrophysics Data System (ADS)

Sakaguchi, Daisaku; Le Amida, Oluwo; Ueki, Hironobu; Ishida, Masahiro

2008-03-01

In order to investigate the distribution of droplet sizes in the core region of diesel fuel spray, instantaneous measurement of droplet sizes was conducted by an advanced laser 2-focus velocimeter (L2F). The micro-scale probe of the L2F is made up of two foci and the distance between them is 36 µm. The tested nozzle had a 0.2 mm diameter single-hole. The measurements of injection pressure, needle lift, and crank angle were synchronized with the measurement by the L2F at the position 10 mm downstream from the nozzle exit. It is clearly shown that the droplet near the spray axis is larger than that in the off-axis region under the needle full lift condition and that the spatial distribution of droplet sizes varies temporally. It is found that the probability density distribution of droplet sizes in the spray core region can be fitted to the Nukiyama-Tanasawa distribution in most injection periods.

African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels

PubMed Central

Annor, Francis; Okosun, Ike; Gower, Barbara A.

2017-01-01

Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25–74 years of age, who are self-identified as NHW (n = 83), AA (n = 56), or WAI (n = 79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = −9.8, p < 0.001) and AA had lower levels than NHW (beta-coefficient = −30.3, p < 0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment. PMID:28250893

Measurement and analysis of x-ray absorption in Al and MgF2 plasmas heated by Z-pinch radiation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

MacFarlane, Joseph John; Rochau, Gregory Alan; Bailey, James E.

2005-06-01

High-power Z pinches on Sandia National Laboratories Z facility can be used in a variety of experiments to radiatively heat samples placed some distance away from the Z-pinch plasma. In such experiments, the heating radiation spectrum is influenced by both the Z-pinch emission and the re-emission of radiation from the high-Z surfaces that make up the Z-pinch diode. To test the understanding of the amplitude and spectral distribution of the heating radiation, thin foils containing both Al and MgF{sub 2} were heated by a 100-130 TW Z pinch. The heating of these samples was studied through the ionization distribution inmore » each material as measured by x-ray absorption spectra. The resulting plasma conditions are inferred from a least-squares comparison between the measured spectra and calculations of the Al and Mg 1s {yields} 2p absorption over a large range of temperatures and densities. These plasma conditions are then compared to radiation-hydrodynamics simulations of the sample dynamics and are found to agree within 1{sigma} to the best-fit conditions. This agreement indicates that both the driving radiation spectrum and the heating of the Al and MgF{sub 2} samples is understood within the accuracy of the spectroscopic method.« less

Etching Enhancement Followed by Nitridation on Low-k SiOCH Film in Ar/C5F10O Plasma

NASA Astrophysics Data System (ADS)

Miyawaki, Yudai; Shibata, Emi; Kondo, Yusuke; Takeda, Keigo; Kondo, Hiroki; Ishikawa, Kenji; Okamoto, Hidekazu; Sekine, Makoto; Hori, Masaru

2013-02-01

The etching rates of low-dielectric-constant (low-k), porous SiOCH (p-SiOCH) films were increased by nitrogen-added Ar/C5F10O plasma etching in dual-frequency (60 MHz/2 MHz)-excited parallel plate capacitively coupled plasma. Previously, perfluoropropyl vinyl ether [C5F10O] provided a very high density of CF3+ ions [Nagai et al.: Jpn. J. Appl. Phys. 45 (2006) 7100]. Surface nitridation on the p-SiOCH surface exposed to Ar/N2 plasma led to the etching of larger amounts of p-SiOCH in Ar/C5F10O plasma, which depended on the formation of bonds such as =C(sp2)=N(sp2)- and -C(sp)≡N(sp).

Plasma turbulence and coherent structures in the polar cap observed by the ICI-2 sounding rocket

NASA Astrophysics Data System (ADS)

Spicher, A.; Miloch, W. J.; Clausen, L. B. N.; Moen, J. I.

2015-12-01

The electron density data from the ICI-2 sounding rocket experiment in the high-latitude F region ionosphere are analyzed using the higher-order spectra and higher-order statistics. Two regions of enhanced fluctuations are chosen for detailed analysis: the trailing edge of a polar cap patch and an electron density enhancement associated with particle precipitation. While these two regions exhibit similar power spectra, our analysis reveals that their internal structures are significantly different. The structures on the edge of the polar cap patch are likely due to nonlinear wave interactions since this region is characterized by intermittency and significant coherent mode coupling. The plasma enhancement subjected to precipitation, however, exhibits stronger random characteristics with uncorrelated phases of density fluctuations. These results suggest that particle precipitation plays a fundamental role in ionospheric plasma structuring creating turbulent-like structures. We discuss the physical mechanisms that cause plasma structuring as well as the possible processes for the low-frequency part of the spectrum in terms of plasma instabilities.

Electron induced ionization of plasma processing gases: C4F x (x  =  1–8) and the isomers of C4F6 and C4F8

NASA Astrophysics Data System (ADS)

Gupta, Dhanoj; Choi, Heechol; Kwon, Deuk-Chul; Yoon, Jung-Sik; Song, Mi-Young

2018-04-01

The total ionization cross section (Q ion) for C4F x (x  =  1–8) fluorocarbons and the isomers of C4F6 and C4F8 molecules are calculated from ionization threshold to 5 keV using the binary-encounter bethe method. The targets are fully optimized using the Hartree–Fock (HF) method and density function theory (DFT) for their minimum energy structure and orbital parameters. The present Q ion with HF parameters showed good agreement with the experimental data for 1,3-C4F6, 2-C4F6, 2-C4F8 and 1-C4F8. On the other hand, the Q ion with DFT parameters are in good accordance with the recent theoretical results for 1,3-C4F6 and 2-C4F6. The Q ion for c-C4F8 showed much variation among the various results. The isomer effect in Q ion is negligible for the isomers of C4F6 and C4F8 molecules. The calculation of Q ion for C4F, C4F2, C4F3, C4F4, C4F5, c-C4F6, C4F7 and iso-C4F8 is a maiden attempt. The present cross section data are important quantities for low temperature plasma modeling especially related to the fluorocarbon plasmas.

Effects of admixture gas on the production of (18)F radioisotope in plasma focus devices.

PubMed

Talaei, Ahmad; Sadat Kiai, S M; Zaeem, A A

2010-12-01

In this article, the effect of admixture gas on the heating and cooling of pinched plasma directly related to the enhancement or reduction of (18)F production through the (16)O((3)He, p)(18)F is considered in the plasma focus devices. It is shown that by controlling the velocity of added Oxygen particles mixed with the working helium gas into the plasma focus chamber, one can increase the current and decrease the confinement time (plasma heating) or vice verse (plasma cooling). The highest level of nuclear activities of (18)F was found around 16% of the Oxygen admixture participation and was about 0.35 MBq in the conditions of 20 kJ, 0.1 Hz and after 2 min operating of Dena PF. However, in the same condition, but for the frequency of 1 Hz, the level of activity increased up to 3.4 MBq. Copyright 2010 Elsevier Ltd. All rights reserved.

Diamagnetic region(s): structure of the unmagnetized plasma around Comet 67P/CG

NASA Astrophysics Data System (ADS)

Henri, P.; Vallières, X.; Hajra, R.; Goetz, C.; Richter, I.; Glassmeier, K.-H.; Galand, M.; Rubin, M.; Eriksson, A. I.; Nemeth, Z.; Vigren, E.; Beth, A.; Burch, J. L.; Carr, C.; Nilsson, H.; Tsurutani, B.; Wattieaux, G.

2017-07-01

The ESA's comet chaser Rosetta has monitored the evolution of the ionized atmosphere of comet 67P/Churyumov-Gerasimenko (67P/CG) and its interaction with the solar wind, during more than 2 yr. Around perihelion, while the cometary outgassing rate was highest, Rosetta crossed hundreds of unmagnetized regions, but did not seem to have crossed a large-scale diamagnetic cavity as anticipated. Using in situ Rosetta observations, we characterize the structure of the unmagnetized plasma found around comet 67P/CG. Plasma density measurements from RPC-MIP are analysed in the unmagnetized regions identified with RPC-MAG. The plasma observations are discussed in the context of the cometary escaping neutral atmosphere, observed by ROSINA/COPS. The plasma density in the different diamagnetic regions crossed by Rosetta ranges from ˜100 to ˜1500 cm-3. They exhibit a remarkably systematic behaviour that essentially depends on the comet activity and the cometary ionosphere expansion. An effective total ionization frequency is obtained from in situ observations during the high outgassing activity phase of comet 67P/CG. Although several diamagnetic regions have been crossed over a large range of distances to the comet nucleus (from 50 to 400 km) and to the Sun (1.25-2.4 au), in situ observations give strong evidence for a single diamagnetic region, located close to the electron exobase. Moreover, the observations are consistent with an unstable contact surface that can locally extend up to about 10 times the electron exobase.

Effect of the chamber wall on fluorocarbon-assisted atomic layer etching of SiO{sub 2} using cyclic Ar/C{sub 4}F{sub 8} plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawakami, Masatoshi; Metzler, Dominik; Oehrlein, Gottlieb S., E-mail: oehrlein@umd.edu

2016-07-15

The authors studied the effect of the temperature and chemical state of the chamber wall on process performance for atomic layer etching of SiO{sub 2} using a steady-state Ar plasma, periodic injection of a defined number of C{sub 4}F{sub 8} molecules, and synchronized plasma-based Ar{sup +} ion bombardment. To evaluate these effects, the authors measured the quartz coupling window temperature. The plasma gas phase chemistry was characterized using optical emission spectroscopy. It was found that although the thickness of the polymer film deposited in each cycle is constant, the etching behavior changed, which is likely related to a change inmore » the plasma gas phase chemistry. The authors found that the main gas phase changes occur after C{sub 4}F{sub 8} injection. The C{sub 4}F{sub 8} and the quartz window react and generate SiF and CO. The emission intensity changes with wall surface state and temperature. Therefore, changes in the plasma gas species generation can lead to a shift in etching performance during processing. During initial cycles, minimal etching is observed, while etching gradually increases with cycle number.« less

Physical vs. photolithographic patterning of plasma polymers: an investigation by ToF-SSIMS and multivariate analysis

PubMed Central

Mishra, Gautam; Easton, Christopher D.; McArthur, Sally L.

2009-01-01

Physical and photolithographic techniques are commonly used to create chemical patterns for a range of technologies including cell culture studies, bioarrays and other biomedical applications. In this paper, we describe the fabrication of chemical micropatterns from commonly used plasma polymers. Atomic force microcopy (AFM) imaging, Time-of-Flight Static Secondary Ion Mass Spectrometry (ToF-SSIMS) imaging and multivariate analysis have been employed to visualize the chemical boundaries created by these patterning techniques and assess the spatial and chemical resolution of the patterns. ToF-SSIMS analysis demonstrated that well defined chemical and spatial boundaries were obtained from photolithographic patterning, while the resolution of physical patterning via a transmission electron microscopy (TEM) grid varied depending on the properties of the plasma system including the substrate material. In general, physical masking allowed diffusion of the plasma species below the mask and bleeding of the surface chemistries. Multivariate analysis techniques including Principal Component Analysis (PCA) and Region of Interest (ROI) assessment were used to investigate the ToF-SSIMS images of a range of different plasma polymer patterns. In the most challenging case, where two strongly reacting polymers, allylamine and acrylic acid were deposited, PCA confirmed the fabrication of micropatterns with defined spatial resolution. ROI analysis allowed for the identification of an interface between the two plasma polymers for patterns fabricated using the photolithographic technique which has been previously overlooked. This study clearly demonstrated the versatility of photolithographic patterning for the production of multichemistry plasma polymer arrays and highlighted the need for complimentary characterization and analytical techniques during the fabrication plasma polymer micropatterns. PMID:19950941

Ionospheric foF2 at EIA region: comparison between observations and IRI model

NASA Astrophysics Data System (ADS)

Chuo, Y. J.; Lee, C. C.

We have used data from an equatorial ionization anomaly area station in the western Pacific region to study the monthly variability of foF2 Diurnal seasonal and solar activity effects were investigated The data established by this study are proposed as valid input values for the development of URSI and CCIR options for the International Reference Ionosphere

Effects of annealing on the optical, structural, and chemical properties of TiO2 and MgF2 thin films prepared by plasma ion-assisted deposition.

PubMed

Woo, Seouk-Hoon; Hwangbo, Chang Kwon

2006-03-01

Effects of thermal annealing at 400 degrees C on the optical, structural, and chemical properties of TiO2 single-layer, MgF2 single-layer, and TiO2/MgF2 narrow-bandpass filters deposited by conventional electron-beam evaporation (CE) and plasma ion-assisted deposition (PIAD) were investigated. In the case of TiO2 films, the results show that the annealing of both CE and PIAD TiO2 films increases the refractive index slightly and the extinction coefficient and surface roughness greatly. Annealing decreases the thickness of CE TiO2 films drastically, whereas it does not vary that of PIAD TiO2 films. For PIAD MgF2 films, annealing increases the refractive index and decreases the extinction coefficient drastically. An x-ray photoelectron spectroscopy analysis suggests that an increase in the refractive index and a decrease in the extinction coefficient for PIAD MgF2 films after annealing may be related to the enhanced concentration of MgO in the annealed PIAD MgF2 films and the changes in the chemical bonding states of Mg 2p, F 1s, and O is. It is found that (TiO2/MgF2) multilayer filters, consisting of PIAD TiO2 and CE MgF2 films, are as deposited without microcracks and are also thermally stable after annealing.

Simulation and analysis of Au-MgF2 structure in plasmonic sensor in near infrared spectral region

NASA Astrophysics Data System (ADS)

Sharma, Anuj K.

2018-05-01

Plasmonic sensor based on metal-dielectric combination of gold and MgF2 layers is studied in near infrared (NIR) spectral region. An emphasis is given on the effect of variable thickness of MgF2 layer in combination with operating wavelength and gold layer thickness on the sensor's performance in NIR. It is established that the variation in MgF2 thickness in connection with plasmon penetration depth leads to significant variation in sensor's performance. The analysis leads to a conclusion that taking smaller values of MgF2 layer thickness and operating at longer NIR wavelength leads to enhanced sensing performance. Also, fluoride glass can provide better sensing performance than chalcogenide glass and silicon substrate.

A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [(18)F]PBR102 and [(18)F]PBR111, in rat and primate plasma.

PubMed

Katsifis, Andrew; Loc'h, Christian; Henderson, David; Bourdier, Thomas; Pham, Tien; Greguric, Ivan; Lam, Peter; Callaghan, Paul; Mattner, Filomena; Eberl, Stefan; Fulham, Michael

2011-01-01

To develop a rapid and reliable method for estimating non-metabolised PBR ligands fluoroethoxy ([(18)F]PBR102)- and fluoropropoxy ([(18)F]PBR111)-substituted 2-(6-chloro-2-phenyl)imidazo[1,2-a]pyridine-3-yl)-N,N-diethylacetamides in plasma. Rats and baboons were imaged with PET up to 2 h postinjection of [(18)F]PBR102 and [(18)F]PBR111 under baseline conditions, after pre-blocking or displacement with PK11195. Arterial plasma samples were directly analysed by reverse-phase solid-phase extraction (RP-SPE) and RP-HPLC and by normal-phase TLC. SPE cartridges were successively washed with acetonitrile/water mixtures. SPE eluant radioactivity was measured in a γ-counter to determine the parent compound fraction and then analysed by HPLC and TLC for validation. In SPE, hydrophilic and lipophilic radiolabelled metabolites were eluted in water and 20% acetonitrile/water. All non-metabolised [(18)F]PBR102 and [(18)F]PBR111 were in SPE acetonitrile fraction as confirmed by HPLC and TLC analysis. Unchanged (%) [(18)F]PBR102 and [(18)F]PBR111 from SPE analysis in rat and baboon plasma agreed with those from HPLC and TLC analysis. In rats and baboons, the fraction of unchanged tracer followed a bi-exponential decrease, with half-lives of 7 to 10 min for the fast component and >80 min for the slow component for both tracers. Direct plasma SPE analysis of [(18)F]PBR102 and [(18)F]PBR111 can reliably estimate parent compound fraction. SPE was superior to HPLC for samples with low activity; it allows rapid and accurate metabolite analysis of a large number of plasma samples for improved estimation of metabolite-corrected input function during quantitative PET imaging studies. Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.

Ionospheric variations over Chinese EIA region using foF2 and comparison with IRI-2016 model

NASA Astrophysics Data System (ADS)

Rao, S. S.; Chakraborty, Monti; Pandey, R.

2018-07-01

In the present work, we have analyzed data of critical frequency of the F2 region (foF2) for the period, 2008-2013 over low latitude Chinese station Guangzhou (Geog. Lat. 23.10°N, Geog. Long. 113.40°E, dip, Lat. 13.49°N) and results thereof have been compared with IRI-2016 model. foF2 data set of the present study encompasses period of unusual and extended solar minimum, i.e., the years 2008-2009 and rising phase of solar cycle 24. IRI data have been obtained by choosing topside electron density profile IRI-NeQuick for two F peak models, CCIR and URSI. It is found that the general trend of variation in foF2 closely follows the trend of the solar flux during the period of study. A linear regression analysis gave a correlation coefficient of 0.98 which shows strong dependence of foF2 variation over solar flux variation. Semi-annual and annual oscillations are clearly brought out in the foF2 data using the Lomb-Scargle periodogram. A presence of semiannual and winter anomaly in observed as well as modeled foF2 at Guangzhou have found to be consistent throughout the period 2008-2013 irrespective of the phases of the solar activity. Our results also show the stronger presence of winter anomaly during the years of higher solar flux and it has been confirmed by normalizing the difference of winter to summer foF2 values for each year. Comparative results of ionosonde observation and IRI-2016 model show a significant discrepancy with regard to values of foF2 in different seasons and local time variations. IRI 2016 model underestimates the foF2 values in winter and equinoxes and overestimates foF2 values in summer. IRI modeled foF2 values using CCIR and URSI F peak models were found greater during forenoon hours and smaller during afternoon hours than the observed foF2 values throughout the period 2008-2013.

Measurement of the deuteron structure function F2 in the resonance region and evaluation of its moments

NASA Astrophysics Data System (ADS)

Osipenko, M.; Ricco, G.; Simula, S.; Battaglieri, M.; Ripani, M.; Adams, G.; Ambrozewicz, P.; Anghinolfi, M.; Asavapibhop, B.; Asryan, G.; Audit, G.; Avakian, H.; Bagdasaryan, H.; Baillie, N.; Ball, J. P.; Baltzell, N. A.; Barrow, S.; Batourine, V.; Beard, K.; Bedlinskiy, I.; Bektasoglu, M.; Bellis, M.; Benmouna, N.; Biselli, A. S.; Bonner, B. E.; Bouchigny, S.; Boiarinov, S.; Bradford, R.; Branford, D.; Brooks, W. K.; Bültmann, S.; Burkert, V. D.; Butuceanu, C.; Calarco, J. R.; Careccia, S. L.; Carman, D. S.; Cazes, A.; Chen, S.; Cole, P. L.; Coleman, A.; Coltharp, P.; Cords, D.; Corvisiero, P.; Crabb, D.; Cummings, J. P.; de Sanctis, E.; Devita, R.; Degtyarenko, P. V.; Denizli, H.; Dennis, L.; Deur, A.; Dharmawardane, K. V.; Djalali, C.; Dodge, G. E.; Donnelly, J.; Doughty, D.; Dragovitsch, P.; Dugger, M.; Dytman, S.; Dzyubak, O. P.; Egiyan, H.; Egiyan, K. S.; Elouadrhiri, L.; Empl, A.; Eugenio, P.; Fatemi, R.; Fedotov, G.; Feuerbach, R. J.; Forest, T. A.; Funsten, H.; Garçon, M.; Gavalian, G.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gordon, C. I. O.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guillo, M.; Guler, N.; Guo, L.; Gyurjyan, V.; Hadjidakis, C.; Hakobyan, R. S.; Hardie, J.; Heddle, D.; Hersman, F. W.; Hicks, K.; Hleiqawi, I.; Holtrop, M.; Hu, J.; Huertas, M.; Hyde-Wright, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Ito, M. M.; Jenkins, D.; Jo, H. S.; Joo, K.; Juengst, H. G.; Kellie, J. D.; Khandaker, M.; Kim, K. Y.; Kim, K.; Kim, W.; Klein, A.; Klein, F. J.; Klimenko, A. V.; Klusman, M.; Kossov, M.; Kramer, L. H.; Kubarovsky, V.; Kuhn, J.; Kuhn, S. E.; Lachniet, J.; Laget, J. M.; Langheinrich, J.; Lawrence, D.; Lee, T.; Li, Ji; Lima, A. C. S.; Livingston, K.; Lukashin, K.; Manak, J. J.; Marchand, C.; McAleer, S.; McKinnon, B.; McNabb, J. W. C.; Mecking, B. A.; Mehrabyan, S.; Melone, J. J.; Mestayer, M. D.; Meyer, C. A.; Mikhailov, K.; Minehart, R.; Mirazita, M.; Miskimen, R.; Mokeev, V.; Morand, L.; Morrow, S. A.; Mueller, J.; Mutchler, G. S.; Nadel-Turonski, P.; Napolitano, J.; Nasseripour, R.; Nefedov, G.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niczyporuk, B. B.; Niyazov, R. A.; Nozar, M.; O'Rielly, G. V.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Philips, S. A.; Pierce, J.; Pivnyuk, N.; Pocanic, D.; Pogorelko, O.; Polli, E.; Pozdniakov, S.; Preedom, B. M.; Price, J. W.; Prok, Y.; Protopopescu, D.; Qin, L. M.; Raue, B. A.; Riccardi, G.; Ritchie, B. G.; Ronchetti, F.; Rosner, G.; Rossi, P.; Rowntree, D.; Rubin, P. D.; Sabatié, F.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Schumacher, R. A.; Serov, V. S.; Sharabian, Y. G.; Shaw, J.; Skabelin, A. V.; Smith, E. S.; Smith, L. C.; Sober, D. I.; Stavinsky, A.; Stepanyan, S. S.; Stepanyan, S.; Stokes, B. E.; Stoler, P.; Strauch, S.; Suleiman, R.; Taiuti, M.; Taylor, S.; Tedeschi, D. J.; Thoma, U.; Thompson, R.; Tkabladze, A.; Todor, L.; Tur, C.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Weinstein, L. B.; Weygand, D. P.; Williams, M.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Yun, J.; Zana, L.; Zhang, J.

2006-04-01

Inclusive electron scattering off the deuteron has been measured to extract the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement covers the entire resonance region from the quasielastic peak up to the invariant mass of the final-state hadronic system W≃2.7 GeV with four-momentum transfers Q2 from 0.4 to 6 (GeV/c)2. These data are complementary to previous measurements of the proton structure function F2 and cover a similar two-dimensional region of Q2 and Bjorken variable x. Determination of the deuteron F2 over a large x interval including the quasielastic peak as a function of Q2, together with the other world data, permit a direct evaluation of the structure function moments for the first time. By fitting the Q2 evolution of these moments with an OPE-based twist expansion we have obtained a separation of the leading twist and higher twist terms. The observed Q2 behavior of the higher twist contribution suggests a partial cancelation of different higher twists entering into the expansion with opposite signs. This cancelation, found also in the proton moments, is a manifestation of the “duality” phenomenon in the F2 structure function.

Plasma mirrors for short pulse KrF lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilicze, Barnabás; Szatmári, Sándor; Barna, Angéla

2016-08-15

It is demonstrated for the first time that plasma mirrors can be successfully applied for KrF laser systems. High reflectivity up to 70% is achieved by optimization of the beam quality on the plasma mirror. The modest spectral shift and the good reflected beam quality allow its applicability for high power laser systems for which a new arrangement is suggested.

Correlations among body temperature, plasma progesterone, cortisol and prostaglandin F2alpha of the periparturient bitch.

PubMed

Veronesi, M C; Battocchio, M; Marinelli, L; Faustini, M; Kindahl, H; Cairoli, F

2002-06-01

The results of this study suggest that, besides the irrelevant role of body temperature measurement to predict the impending parturition in the bitch, progesterone and 15-ketodihydroprostaglandin F2alpha plasma level records could be more suitable to detect the approaching whelping in this species. More interesting was the statistically significant substantial increase in body temperature beginning 12 h after the onset of parturition. Therefore, if any significant increase in body temperature is recorded at the end of pregnancy without the beginning of the expulsion of fetuses, it could indicate problems at parturition. In this study, cortisol levels increased significantly at the time of delivery and remained high 12 h after the beginning of parturition, decreasing within 36 h after the onset of whelping. 15-ketodihydro-prostaglandin F2alpha levels increased significantly 24 h before parturition and again at the onset of whelping. Progesterone levels decreased significantly, starting 24 h before the onset of whelping and remained low after delivery.

Fluorocarbon assisted atomic layer etching of SiO 2 and Si using cyclic Ar/C 4F 8 and Ar/CHF 3 plasma

DOE PAGES

Metzler, Dominik; Li, Chen; Engelmann, Sebastian; ...

2015-11-11

The need for atomic layer etching (ALE) is steadily increasing as smaller critical dimensions and pitches are required in device patterning. A flux-control based cyclic Ar/C 4F 8 ALE based on steady-state Ar plasma in conjunction with periodic, precise C 4F 8 injection and synchronized plasma-based low energy Ar + ion bombardment has been established for SiO 2. 1 In this work, the cyclic process is further characterized and extended to ALE of silicon under similar process conditions. The use of CHF 3 as a precursor is examined and compared to C 4F 8. CHF 3 is shown to enablemore » selective SiO 2/Si etching using a fluorocarbon (FC) film build up. Other critical process parameters investigated are the FC film thickness deposited per cycle, the ion energy, and the etch step length. Etching behavior and mechanisms are studied using in situ real time ellipsometry and X-ray photoelectron spectroscopy. Silicon ALE shows less self-limitation than silicon oxide due to higher physical sputtering rates for the maximum ion energies used in this work, ranged from 20 to 30 eV. The surface chemistry is found to contain fluorinated silicon oxide during the etching of silicon. As a result, plasma parameters during ALE are studied using a Langmuir probe and establish the impact of precursor addition on plasma properties.« less

Study of midlatitude ionospheric irregularities and E- and F-region coupling based on rocket and radar observations from Japan

NASA Astrophysics Data System (ADS)

Yamamoto, M.

2015-12-01

We have been studying ionspheric irregularities in mid-latitude region by using radars, sounding rockets, etc. The mid-latitude ionosphere was considered much stable than those in the equatorial or polar region in the past, but our studies for years have revealed that there are much active variabilities. We found variety of wave-like structures that are specific in the mid-latitudes. One of the phenomena is quasi-periodic echoes (QP echoes) first observed by the MU radar that reflects horizontal plasma-density structures associated to sporadic-E layers. Another phenomenon is medium-scale traveling ionospheric disturbance (MSTID) in the F-region. In the generation mechanism we think that Ionospheric E- and F-region coupling process is important. In this presentation, we will discuss nature of mid-latitude ionosphere based on our observations; the MU radar, sounding rocket campaigns of SEEK-1/2, and recent MSTID rocket experiment from JAXA Uchinoura Space Center in July 2013.

F2-isoprostanes and F4-neuroprostanes as markers of intracranial aneurysm development.

PubMed

Syta-Krzyżanowska, Anna; Jarocka-Karpowicz, Iwona; Kochanowicz, Jan; Turek, Grzegorz; Rutkowski, Robert; Gorbacz, Krzysztof; Mariak, Zenon; Skrzydlewska, Elżbieta

2018-04-24

Intracranial aneurysms are common, occurring in about 1-2% of the population. Saccular aneurysm is a pouch-like pathological dilatation of an intracranial artery that develops when the cerebral artery wall becomes too weak to resist hemodynamic pressure and distends. The aim of this study was to determine whether the development of intracranial aneurysms and subarachnoid hemorrhage (SAH) affects neuronal phospholipid metabolism, and what influence different invasive treatments have on brain free radical phospholipid metabolism. The level of polyunsaturated fatty acid (PUFA) cyclization products - F2-isoprostanes and F4-neuroprostanes - was examined using liquid chromatography - mass spectrometry (LC-MS) in the plasma of patients with brain aneurysm and resulting subarachnoid hemorrhage. It was revealed that an aneurysm leads to the enhancement of lipid peroxidation with a significant increase in plasma F2-isoprostanes and F4-neuroprostanes (more than 3-fold and 11-fold, respectively) in comparison to healthy subjects. The rupture of an aneurysm results in hemorrhage and an additional increase in examined prostaglandin derivatives. The embolization and clipping of aneurysms contribute to a gradual restoration of metabolic homeostasis in brain cells, which is visible in the decrease in PUFA cyclization products. The results indicate that aneurysm development is associated with enhanced inflammation and oxidative stress, factors which favor lipid peroxidation, particularly in neurons, whose membranes are rich in docosahexaenoic acid, a precursor of F4-neuroprostanes.

Observations on the Daytime F-region Irregularities in Two Magnetic Quiet Days Using Hainan Coherent Scatter Phased Array Radar (HCOPAR)

NASA Astrophysics Data System (ADS)

Jin, H.; Chen, G.

2017-12-01

In the magnetic quiet afternoon on 22 July 2013 and noon on 23 May 2016 , Hainan coherent scatter phased array radar (HCOPAR) located at low latitude of China has recorded two cases of the extremely rare daytime F region irregularities. The field-aligned irregularities (FAIs) appeared in the topside F2 layer with small Doppler velocities and narrow spectral widths. The time sequence of the fan sector maps shows the FAIs of 2016 moved northward with almost no zonal drift velocity. The Kp and DST indexes indicate that the irregularities emerged in the magnetic quiet days, so the irregularities were irrelevant to the storm-induced eastward electric field as other daytime cases. More than 2 h after the emergency of the daytime irregularities over Hainan, the Shaoyang digisonde situated 870 km north to the HCOPAR recorded the spread-F in ionospheric F1 layer. According to the echo altitudes, the spread-F may connect the daytime bubbles via magnetic field line. It is difficult for F-region irregularities to survive in the sunlit ionosphere due to the strong photoionization after sunrise. Consequently, the daytime FAIs over Hainan may travel from higher altitudes in the south along the geomagnetic field and are most likely the remnant of postsunset/postmidnight plasma bubbles.

The Association of Myosin IB with Actin Waves in Dictyostelium Requires Both the Plasma Membrane-Binding Site and Actin-Binding Region in the Myosin Tail

PubMed Central

Brzeska, Hanna; Pridham, Kevin; Chery, Godefroy; Titus, Margaret A.; Korn, Edward D.

2014-01-01

F-actin structures and their distribution are important determinants of the dynamic shapes and functions of eukaryotic cells. Actin waves are F-actin formations that move along the ventral cell membrane driven by actin polymerization. Dictyostelium myosin IB is associated with actin waves but its role in the wave is unknown. Myosin IB is a monomeric, non-filamentous myosin with a globular head that binds to F-actin and has motor activity, and a non-helical tail comprising a basic region, a glycine-proline-glutamine-rich region and an SH3-domain. The basic region binds to acidic phospholipids in the plasma membrane through a short basic-hydrophobic site and the Gly-Pro-Gln region binds F-actin. In the current work we found that both the basic-hydrophobic site in the basic region and the Gly-Pro-Gln region of the tail are required for the association of myosin IB with actin waves. This is the first evidence that the Gly-Pro-Gln region is required for localization of myosin IB to a specific actin structure in situ. The head is not required for myosin IB association with actin waves but binding of the head to F-actin strengthens the association of myosin IB with waves and stabilizes waves. Neither the SH3-domain nor motor activity is required for association of myosin IB with actin waves. We conclude that myosin IB contributes to anchoring actin waves to the plasma membranes by binding of the basic-hydrophobic site to acidic phospholipids in the plasma membrane and binding of the Gly-Pro-Gln region to F-actin in the wave. PMID:24747353

Bottomside sinusoidal irregularities in the equatorial F region. II - Cross-correlation and spectral analysis

NASA Technical Reports Server (NTRS)

Cragin, B. L.; Hanson, W. B.; Mcclure, J. P.; Valladares, C. E.

1985-01-01

Equatorial bottomside sinusoidal (BSS) irregularities have been studied by applying techniques of cross-correlation and spectral analysis to the Atmosphere Explorer data set. The phase of the cross-correlations of the plasma number density is discussed and the two drift velocity components observed using the retarding potential analyzer and ion drift meter on the satellite are discussed. Morphology is addressed, presenting the geographical distributions of the occurrence of BSS events for the equinoxes and solstices. Physical processes including the ion Larmor flux, interhemispheric plasma flows, and variations in the lower F region Pedersen conductivity are invoked to explain the findings.

Properties of C4F7N–CO2 thermal plasmas: thermodynamic properties, transport coefficients and emission coefficients

NASA Astrophysics Data System (ADS)

Wu, Yi; Wang, Chunlin; Sun, Hao; Murphy, Anthony B.; Rong, Mingzhe; Yang, Fei; Chen, Zhexin; Niu, Chunpin; Wang, Xiaohua

2018-04-01

The thermophysical properties, including composition, thermodynamic properties, transport coefficients and net emission coefficients, of thermal plasmas formed from pure iso-C4 perfluoronitrile C4F7N and C4F7N–CO2 mixtures are calculated for temperatures from 300 to 30 000 K and pressures from 0.1 to 20 atm. These gases have received much attention as alternatives to SF6 for use in circuit breakers, due to the low global warming potential and good dielectric properties of C4F7N. Since the parameters of the large molecules formed in the dissociation of C4F7N are unavailable, the partition function and enthalpy of formation were calculated using computational chemistry methods. From the equilibrium composition calculations, it was found that when C4F7N is mixed with CO2, CO2 can capture C atoms from C4F7N, producing CO, since the system consisting of small molecules such as CF4 and CO has lower energy at room temperature. This is in agreement with previous experimental results, which show that CO dominates the decomposition products of C4F7N–CO2 mixtures; it could limit the repeated breaking performance of C4F7N. From the point of view of chemical stability, the mixing ratio of CO2 should therefore be chosen carefully. Through comparison with common arc quenching gases (including SF6, CF3I and C5F10O), it is found that for the temperature range for which electrical conductivity remains low, pure C4F7N has similar ρC p (product of mass density and specific heat) properties to SF6, and higher radiative emission coefficient, properties that are correlated with good arc extinguishing capability. For C4F7N–CO2 mixtures, the electrical conductivity is very close to that of SF6 while the ρC p peak at 7000 K caused by decomposition of CO implies inferior interruption capability to that of SF6. The calculated properties will be useful in arc simulations.

The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane.

PubMed

Fort, Joana; de la Ballina, Laura R; Burghardt, Hans E; Ferrer-Costa, Carles; Turnay, Javier; Ferrer-Orta, Cristina; Usón, Isabel; Zorzano, Antonio; Fernández-Recio, Juan; Orozco, Modesto; Lizarbe, María Antonia; Fita, Ignacio; Palacín, Manuel

2007-10-26

4F2hc (CD98hc) is a multifunctional type II membrane glycoprotein involved in amino acid transport and cell fusion, adhesion, and transformation. The structure of the ectodomain of human 4F2hc has been solved using monoclinic (Protein Data Bank code 2DH2) and orthorhombic (Protein Data Bank code 2DH3) crystal forms at 2.1 and 2.8 A, respectively. It is composed of a (betaalpha)(8) barrel and an antiparallel beta(8) sandwich related to bacterial alpha-glycosidases, although lacking key catalytic residues and consequently catalytic activity. 2DH3 is a dimer with Zn(2+) coordination at the interface. Human 4F2hc expressed in several cell types resulted in cell surface and Cys(109) disulfide bridge-linked homodimers with major architectural features of the crystal dimer, as demonstrated by cross-linking experiments. 4F2hc has no significant hydrophobic patches at the surface. Monomer and homodimer have a polarized charged surface. The N terminus of the solved structure, including the position of Cys(109) residue located four residues apart from the transmembrane domain, is adjacent to the positive face of the ectodomain. This location of the N terminus and the Cys(109)-intervening disulfide bridge imposes space restrictions sufficient to support a model for electrostatic interaction of the 4F2hc ectodomain with membrane phospholipids. These results provide the first crystal structure of heteromeric amino acid transporters and suggest a dynamic interaction of the 4F2hc ectodomain with the plasma membrane.

Scintillations associated with bottomside sinusoidal irregularities in the equatorial F region

NASA Technical Reports Server (NTRS)

Basu, S.; Basu, S.; Valladares, C. E.; Dasgupta, A.; Whitney, H. E.

1986-01-01

Multisatellite scintillation observations and spaced receiver drift measurements are presented for a category of equatorial F region plasma irregularities characterized by nearly sinusoidal waveforms in the ion number density. The observations were made at Huancayo, Peru, and the measurements at Ancon, Peru, associated with irregularities observed by the Atmospheric-Explorer-E satellite on a few nights in December 1979. Utilizing ray paths to various geostationary satellites, it was found that the irregularities grow and decay almost simultaneously in long-lived patches extending at least 1000 km in the east-west direction.

Composite films prepared by plasma ion-assisted deposition (IAD) for design and fabrication of antireflection coatings in visible and near-infrared spectral regions

NASA Astrophysics Data System (ADS)

Tsai, Rung-Ywan; Ho, Fang C.

1994-11-01

Ion-assisted deposition (IAD) processes configured with a well-controlled plasma source at the center base of a vacuum chamber, which accommodates two independent e-gun sources, is used to deposition TiO2MgF2 and TiO2-SiO2 composite films of selected component ratios. Films prepared by this technology are found durable, uniform, and nonabsorbing in visible and near-IR regions. Single- and multilayer antireflection coatings with refractive index from 1.38 to 2.36 at (lambda) equals 550 nm are presented. Methods of enhancement in optical performance of these coatings are studied. The advantages of AR coatings formed by TiO2-MgF2 composite films over those similar systems consisting of TiO2-SiO2 composite films in both visible and near-IR regions are also presented.

Detection of F-region electron density irregularities using incoherent-scatter radar

NASA Astrophysics Data System (ADS)

Gudivada, Krishna Prasad

Incoherent-scatter radar data from Poker Flat, Alaska has been used to determine size distributions of electron density structures in the evening time sector of the auroral zone. At high latitudes ionospheric plasma typically moves east-west with speeds of several hundred meters per second. Density irregularities that rapidly move through the radar beam are therefore observed as time-varying power fluctuations. The new phased array radar used for this study has been operated with several antenna directions with successive pulses transmitted in each direction. It is therefore possible to observe plasma Doppler velocities in multiple directions and determine the vector direction of the plasma motion. This near-simultaneous observation of the plasma velocity in conjunction with the electron density height profile data enable a new technique to determine the scale sizes of electron density fluctuations that move horizontally through the radar beam. The study focuses on the collision-less F-region ionosphere where the plasma drift is approximately constant with altitude. The experimental technique limits the range of scale sizes that may be studied to relatively large-scale sizes (i.e. greater than few tens of km). Results show that during magnetically disturbed conditions (Kp ≥ 4) when westward plasma velocities are relatively high (500-1000 m/s) the scale sizes of irregularities (often called plasma blobs) are in the range of 100-300 km and predominantly originate from the polar cap and are transported over long distances (˜1000 km) due to the long chemical recombination times (30-90 minutes). Some irregularities are caused by local auroral particle precipitation and have been identified with associated electron temperature enhancements. For cases of low magnetic activity (Kp ≤ 1), when the radar is located in a region of low plasma velocities (100-500 m/s) well south of the auroral oval (essentially a mid-latitude type ionosphere), the density distribution is

C/NOFS Satellite Electric Field and Plasma Density Observations of Plasma Instabilities Below the Equatorial F-Peak -- Evidence for Approximately 500 km-Scale Spread-F "Precursor" Waves Driven by Zonal Shear Flow and km-Scale, Narrow-Banded Irregularities

NASA Technical Reports Server (NTRS)

Pfaff, R.; Freudenreich, H.; Klenzing, J.; Liebrecht, C.; Valladares, C.

2011-01-01

As solar activity has increased, the ionosphere F-peak has been elevated on numerous occasions above the C/NOFS satellite perigee of 400km. In particular, during the month of April, 2011, the satellite consistently journeyed below the F-peak whenever the orbit was in the region of the South Atlantic anomaly after sunset. During these passes, data from the electric field and plasma density probes on the satellite have revealed two types of instabilities which had not previously been observed in the C/NOFS data set (to our knowledge): The first is evidence for 400-500km-scale bottomside "undulations" that appear in the density and electric field data. In one case, these large scale waves are associated with a strong shear in the zonal E x B flow, as evidenced by variations in the meridional (outward) electric fields observed above and below the F-peak. These undulations are devoid of smaller scale structures in the early evening, yet appear at later local times along the same orbit associated with fully-developed spread-F with smaller scale structures. This suggests that they may be precursor waves for spread-F, driven by a collisional shear instability, following ideas advanced previously by researchers using data from the Jicamarca radar. A second new result (for C/NOFS) is the appearance of km-scale irregularities that are a common feature in the electric field and plasma density data that also appear when the satellite is below the F -peak at night. The vector electric field instrument on C/NOFS clearly shows that the electric field component of these waves is strongest in the zonal direction. These waves are strongly correlated with simultaneous observations of plasma density oscillations and appear both with, and without, evidence of larger-scale spread-F depletions. These km-scale, quasi-coherent waves strongly resemble the bottomside, sinusoidal irregularities reported in the Atmosphere Explorer satellite data set by Valladares et al. [JGR, 88, 8025, 1983

Studies of ionospheric F-region response in the Latin American sector during the geomagnetic storm of 21-22 January 2005

NASA Astrophysics Data System (ADS)

Sahai, Y.; Fagundes, P. R.; de Jesus, R.; de Abreu, A. J.; Crowley, G.; Kikuchi, T.; Huang, C.-S.; Pillat, V. G.; Guarnieri, F. L.; Abalde, J. R.; Bittencourt, J. A.

2011-05-01

In the present investigation, we have studied the response of the ionospheric F-region in the Latin American sector during the intense geomagnetic storm of 21-22 January 2005. This geomagnetic storm has been considered "anomalous" (minimum Dst reached -105 nT at 07:00 UT on 22 January) because the main storm phase occurred during the northward excursion of the Bz component of interplanetary magnetic fields (IMFs). The monthly mean F10.7 solar flux for the month of January 2005 was 99.0 sfu. The F-region parameters observed by ionosondes at Ramey (RAM; 18.5° N, 67.1° W), Puerto Rico, Jicamarca (JIC; 12.0° S, 76.8° W), Peru, Manaus (MAN; 2.9° S, 60.0° W), and São José dos Campos (SJC; 23.2° S, 45.9° W), Brazil, during 21-22 January (geomagnetically disturbed) and 25 January (geomagnetically quiet) have been analyzed. Both JIC and MAN, the equatorial stations, show unusually rapid uplifting of the F-region peak heights (hpF2/hmF2) and a decrease in the NmF2 coincident with the time of storm sudden commencement (SSC). The observed variations in the F-region ionospheric parameters are compared with the TIMEGCM model run for 21-22 January and the model results show both similarities and differences from the observed results. Average GPS-TEC (21, 22 and 25 January) and phase fluctuations (21, 22, 25, 26 January) observed at Belem (BELE; 1.5° S, 48.5° W), Brasilia (BRAZ; 15.9° S, 47.9° W), Presidente Prudente (UEPP; 22.3° S, 51.4° W), and Porto Alegre (POAL; 30.1° S, 51.1° W), Brazil, are also presented. These GPS stations belong to the RBMC/IBGE network of Brazil. A few hours after the onset of the storm, large enhancements in the VTEC and NmF2 between about 20:00 and 24:00 UT on 21 January were observed at all the stations. However, the increase in VTEC was greatest at the near equatorial station (BELE) and enhancements in VTEC decreased with latitude. It should be pointed out that no phase fluctuations or spread-F were observed in the Latin American

Equatorial plasma bubbles/range spread F irregularities and the QBO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, P.R.

1993-11-05

This paper reports on a study of plasma bubbles or spread F irregularities, observed at equatorial observation stations, looked at in conjunction with measures of the quasi biennial oscillation (QBO) of the mean lower stratospheric winds. Plasma bubbles and spread F irregularities are thought to be different manifestations of the same basic event, distinguished mainly by the observational method. For the case of range spread F events, ionosonde data has revealed in the past daily and seasonal variations, effects due to the solar cycle, and dependence upon the geomagnetic field and longitudinal location. These relationships have been shown to bemore » statistical in nature, so the authors have looked for other relationships which might be more relational in nature. When correlation with QBO phase variations are investigated, there is an observed increase or decrease in the range spread F, dependent upon whether the QBO is in an easterly or westerly phase, and observed in the American sector or Indian/East African sector.« less

An investigation of ionospheric F region response in the Brazilian sector to the super geomagnetic storm of May 2005

NASA Astrophysics Data System (ADS)

de Abreu, A. J.; Sahai, Y.; Fagundes, P. R.; de Jesus, R.; Bittencourt, J. A.; Pillat, V. G.

2011-10-01

In this paper, we have investigated the responses of the ionospheric F region at equatorial and low latitude regions in the Brazilian sector during the super geomagnetic storm on 15-16 May 2005. The geomagnetic storm reached a minimum Dst of -263 nT at 0900 UT on 15 May. In this paper, we present vertical total electron content (vTEC) and phase fluctuations (in TECU/min) from Global Positioning System (GPS) observations obtained at Belém, Brasília, Presidente Prudente, and Porto Alegre, Brazil, during the period 14-17 May 2005. Also, we present ionospheric parameters h'F, hpF2, and foF2, using the Canadian Advanced Digital Ionosonde (CADI) obtained at Palmas and São José dos Campos, Brazil, for the same period. The super geomagnetic storm has fast decrease in the Dst index soon after SSC at 0239 UT on 15 May. It is a good possibility of prompt penetration of electric field of magnetospheric origin resulting in uplifting of the F region. The vTEC observations show a trough at BELE and a crest above UEPP, soon after SSC, indicating strengthening of nighttime equatorial anomaly. During the daytime on 15 and 16 May, in the recovery phase, the variations in foF2 at SJC and the vTEC observations, particularly at BRAZ, UEPP, and POAL, show large positive ionospheric storm. There is ESF on the all nights at PAL, in the post-midnight (UT) sector, and phase fluctuations only on the night of 14-15 May at BRAZ, after the SSC. No phase fluctuations are observed at the equatorial station BELE and low latitude stations (BRAZ, UEPP, and POAL) at all other times. This indicates that the plasma bubbles are generated and confined on this magnetically disturbed night only up to the low magnetic latitude and drifted possibly to west.

Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis.

PubMed

Takeda, Tetsuya; Robinson, Iain M; Savoian, Matthew M; Griffiths, John R; Whetton, Anthony D; McMahon, Harvey T; Glover, David M

2013-08-07

Cytokinesis is a highly ordered cellular process driven by interactions between central spindle microtubules and the actomyosin contractile ring linked to the dynamic remodelling of the plasma membrane. The mechanisms responsible for reorganizing the plasma membrane at the cell equator and its coupling to the contractile ring in cytokinesis are poorly understood. We report here that Syndapin, a protein containing an F-BAR domain required for membrane curvature, contributes to the remodelling of the plasma membrane around the contractile ring for cytokinesis. Syndapin colocalizes with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) at the cleavage furrow, where it directly interacts with a contractile ring component, Anillin. Accordingly, Anillin is mislocalized during cytokinesis in Syndapin mutants. Elevated or diminished expression of Syndapin leads to cytokinesis defects with abnormal cortical dynamics. The minimal segment of Syndapin, which is able to localize to the cleavage furrow and induce cytokinesis defects, is the F-BAR domain and its immediate C-terminal sequences. Phosphorylation of this region prevents this functional interaction, resulting in reduced ability of Syndapin to bind to and deform membranes. Thus, the dephosphorylated form of Syndapin mediates both remodelling of the plasma membrane and its proper coupling to the cytokinetic machinery.

Observations of unusual pre-dawn response of the equatorial F-region during geomagnetic disturbances

NASA Astrophysics Data System (ADS)

Lima, W.; Becker-Guedes, F.; Fagundes, P.; Sahai, Y.; Abalde, J.; Pillat, V.

It is known that the disturbed solar wind-magnetosphere interactions have important effects on equatorial and low-latitude ionospheric electrodynamics. The response of equatorial ionosphere during storm-time is an important aspect of space weather studies. It has been observed that during geomagnetic disturbances both suppression as well as generation of equatorial spread-F (ESF) or plasma irregularities takes place. However, the mechanism(s) associated with the generation of ESF still needs further investigations. This work reports some unusual events of pre-dawn occurrence of ionospheric F-region satellite traces followed by spread-F and cusp-like spread-F from ionospheric sounding observations carried out by a Canadian Advanced Digital Ionosonde (CADI) localized at Palmas (10.2°, 48.2°W, dip latitude 5.7°S), Brazil during 2002, every 5 minutes. For the present work we have scaled and analyzed the ionospheric sounding data for three events (April 20, September 04 and 08, 2002), which are associated with geomagnetic disturbances. In the events studied, the ionograms show the occurrence of satellite trace followed by cusp-like spread. The cusp like features move up in frequency and height and finally attain the F-layer peak value (foF2) and then disappear. They had duration of about 30 min and always occurred in the early morning hours. Our studies involved seven geomagnetic disturbances as well as quiet days during the year 2002, but only on these three occasions we observed these features. We present and discuss these observations in this paper and suggest possible mechanisms for the occurrence of these unusual features.

Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in C57BL/6J x RR F2 mice.

PubMed

Suto, Jun-ichi; Takahashi, Yuji; Sekikawa, Kenji

2004-10-01

A highly significant cholesterol quantitative trait locus (QTL) (Cq6) was identified on chromosome 1 in C57BL/6J x RR F2 mice. The Cq6 was located over the gene for apolipoprotein A-Il (Apoa2), and the RR allele was associated with increased plasma cholesterol. C57BL/6J has Apoa2a alleles and RR has Apoa2b alleles. Three different Apoa2 alleles are known on the basis of amino acid substitutions at four residues. Analysis with partial Apoa2 congenic strains possessing Apoa2a, Apoa2b, and Apoa2C alleles revealed that the Apoa2b allele is unique in the ability to increase cholesterol among the three Apoa2 alleles, and that the Ala-to-Val substitution at residue 61 may be crucial as far as cholesterol metabolism is concerned. We also investigated the question of whether the Apoa1 gene is responsible for the cholesterol QTLs (Cq4 and Cq5) that had been identified previously on chromosome 9 in C57BL/6J x KK-Ay/a F2 and in KK x RR F2, but not in C57BL/6J x RR F2 mice. Similar to Apoa2 alleles, three different Apoal alleles with two successive amino acid substitutions were revealed among the strains. However, we could not correlate Apoal polymorphisms with the occurrence of QTLs in these three sets of F2 mice.

Effects of glucose, insulin, and insulin resistance on cerebral 18F-FDG distribution in cognitively normal older subjects

PubMed Central

Onishi, Airin; Fujiwara, Yoshinori; Ishiwata, Kiichi; Ishii, Kenji

2017-01-01

Background Increasing plasma glucose levels and insulin resistance can alter the distribution pattern of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) in the brain and relatively reduce 18F-FDG uptake in Alzheimer's disease (AD)-related hypometabolic regions, leading to the appearance of an AD-like pattern. However, its relationship with plasma insulin levels is unclear. We aimed to compare the effects of plasma glucose levels, plasma insulin levels and insulin resistance on the appearance of the AD-like pattern in 18F-FDG images. Methods Fifty-nine cognitively normal older subjects (age = 75.7 ± 6.4 years) underwent 18F-FDG positron emission tomography along with measurement of plasma glucose and insulin levels. As an index of insulin resistance, the Homeostasis model assessment of Insulin Resistance (HOMA-IR) was calculated. Results Plasma glucose levels, plasma insulin levels, and HOMA-IR were 102.2 ± 8.1 mg/dL, 4.1 ± 1.9 μU/mL, and 1.0 ± 0.5, respectively. Whole-brain voxelwise analysis showed a negative correlation of 18F-FDG uptake with plasma glucose levels in the precuneus and lateral parietotemporal regions (cluster-corrected p < 0.05), and no correlation with plasma insulin levels or HOMA-IR. In the significant cluster, 18F-FDG uptake decreased by approximately 4–5% when plasma glucose levels increased by 20 mg/dL. In the precuneus region, volume-of-interest analysis confirmed a negative correlation of 18F-FDG uptake with plasma glucose levels (r = -0.376, p = 0.002), and no correlation with plasma insulin levels (r = 0.156, p = 0.12) or HOMA-IR (r = 0.096, p = 0.24). Conclusion This study suggests that, of the three parameters, plasma glucose levels have the greatest effect on the appearance of the AD-like pattern in 18F-FDG images. PMID:28715453

Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride.

PubMed

Riccardi, Patrizia; Baldwin, Ron; Salomon, Ronald; Anderson, Sharlet; Ansari, Mohammad S; Li, Rui; Dawant, Benoit; Bauernfeind, Amy; Schmidt, Dennis; Kessler, Robert

2008-01-15

This study examined whether positron emission tomography (PET) studies with [18F] fallypride performed before and after alpha-methyl-para-tyrosine (AMPT) administration can be used to estimate baseline dopamine (DA) D2 receptor occupancy in striatal and extrastriatal regions. Six normal subjects underwent PET with [18 F] fallypride before and after administration of AMPT. The DA D2 receptor binding potentials (bp) were calculated with the reference region method. Percent changes in bp in striatal and extrastriatal regions were calculated with both region-of-interest analysis and on a voxel by voxel basis with parametric images of DA D2 receptor levels. The results of the current study indicate that AMPT treatment significantly increased the bp in the caudate, putamen, ventral striatum, and substantia nigra. A trend level increase was seen in the medial thalamus. This study demonstrates that PET with [18F] fallypride can be used to estimate baseline DA D2 receptor occupancy in striatal and extrastriatal regions.

Observation of parametric instabilities in the quarter critical density region driven by the Nike KrF laser

NASA Astrophysics Data System (ADS)

Weaver, J. L.; Oh, J.; Phillips, L.; Afeyan, B.; Seely, J.; Kehne, D.; Brown, C. M.; Obenschain, S. P.; Serlin, V.; Schmitt, A. J.; Feldman, U.; Lehmberg, R. H.; Mclean, E.; Manka, C.

2013-02-01

The krypton-fluoride (KrF) laser is an attractive choice for inertial confinement fusion due to its combination of short wavelength (λ =248 nm), large bandwidth (up to 3 THz), and superior beam smoothing by induced spatial incoherence. These qualities improve the overall hydrodynamics of directly driven pellet implosions and should allow use of increased laser intensity due to higher thresholds for laser plasma instabilities when compared to frequency tripled Nd:glass lasers (λ =351 nm). Here, we report the first observations of the two-plasmon decay instability using a KrF laser. The experiments utilized the Nike laser facility to irradiate solid plastic planar targets over a range of pulse lengths (0.35 ns≤τ≤1.25 ns) and intensities (up to 2×1015 W/cm2). Variation of the laser pulse created different combinations of electron temperature and electron density scale length. The observed onset of instability growth was consistent with the expected scaling that KrF lasers have a higher intensity threshold for instabilities in the quarter critical density region.

Measurement of the Structure Function Ratio $$F^{\\eta}_2$$ /$$ F^p_2$$ in Muon - Nucleon Scattering at Low $x$ and $$Q^{2}$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spentzouris, Panagiotis

1994-12-01

The ratio of the neutron to proton structure functions,more » $$F^{\\eta}_2$$ / $$F^p_2$$, from scattering of 470 GeV muons on liquid hydrogen and deuterium targets, is measured at very small-x and $Q^2$ , using the Fermilab E665 spectrometer. The results presented cover the region 0.000004 < x < 0.3 and $Q^2$ > 0.001 $GeV^2$ , three orders of magnitude lower in z than previous fixed-target experiments, and with higher average Q2 in the overlap region....« less

Medium-scale gravity wave activity in the bottomside F region in tropical regions

NASA Astrophysics Data System (ADS)

Liu, Huixin; Pedatella, Nicholas; Hocke, Klemens

2017-07-01

Thermospheric gravity waves (GWs) in the bottomside F region have been proposed to play a key role in the generation of equatorial plasma bubbles (EPBs). However, direct observations of such waves are scarce. This study provides a systematic survey of medium-scale (<620 km) neutral atmosphere perturbations at this critical altitude in the tropics, using 4 years of in situ Gravity Field and Steady-State Ocean Circulation Explorer satellite measurements of thermospheric density and zonal wind. The analysis reveals pronounced features on their global distribution and seasonal variability: (1) A prominent three-peak longitudinal structure exists in all seasons, with stronger perturbations over continents than over oceans. (2) Their seasonal variation consists of a primary semiannual oscillations (SAO) and a secondary annual oscillation (AO). The SAO component maximizes around solstices and minimizes around equinoxes, while the AO component maximizes around June solstice. These GW features resemble those of EPBs in spatial distribution but show opposite trend in climatological variations. This may imply that stronger medium-scale GW activity does not always lead to more EPBs. Possible origins of the bottomside GWs are discussed, among which tropical deep convection appears to be most plausible.

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans.

PubMed

Patt, Marianne; Becker, Georg A; Grossmann, Udo; Habermann, Bernd; Schildan, Andreas; Wilke, Stephan; Deuther-Conrad, Winnie; Graef, Susanne; Fischer, Steffen; Smits, René; Hoepping, Alexander; Wagenknecht, Gudrun; Steinbach, Jörg; Gertz, Hermann-Josef; Hesse, Swen; Schönknecht, Peter; Brust, Peter; Sabri, Osama

2014-07-01

(-)-[(18)F]Flubatine is a PET tracer with high affinity and selectivity for the nicotinic acetylcholine α4β2 receptor subtype. A clinical trial assessing the availability of this subtype of nAChRs was performed. From a total participant number of 21 Alzheimer's disease (AD) patients and 20 healthy controls (HCs), the following parameters were determined: plasma protein binding, metabolism and activity distribution between plasma and whole blood. Plasma protein binding and fraction of unchanged parent compound were assessed by ultracentrifugation and HPLC, respectively. The distribution of radioactivity (parent compound+metabolites) between plasma and whole blood was determined ex vivo at different time-points after injection by gamma counting after separation of whole blood by centrifugation into the cellular and non-cellular components. In additional experiments in vitro, tracer distribution between these blood components was assessed for up to 90min. A fraction of 15%±2% of (-)-[(18)F]Flubatine was found to be bound to plasma proteins. Metabolic degradation of (-)-[(18)F]Flubatine was very low, resulting in almost 90% unchanged parent compound at 90min p.i. with no significant difference between AD and HC. The radioactivity distribution between plasma and whole blood changed in vivo only slightly over time from 0.82±0.03 at 3min p.i. to 0.87±0.03 at 270min p.i. indicating the contribution of only a small amount of metabolites. In vitro studies revealed that (-)-[(18)F]Flubatine was instantaneously distributed between cellular and non-cellular blood parts. (-)-[(18)F]Flubatine exhibits very favourable characteristics for a PET radiotracer such as slow metabolic degradation and moderate plasma protein binding. Equilibrium of radioactivity distribution between plasma and whole blood is reached instantaneously and remains almost constant over time allowing both convenient sample handling and facilitated fractional blood volume contribution assessment. Copyright

Space Weather Effects on the Dynamics of Equatorial F Region Irregularities

NASA Astrophysics Data System (ADS)

Bhattacharyya, A.; Basu, S.; Groves, K.; Valladares, C.; Sheehan, R.

Space weather effects on transionospheric radio waves used for navigation and communication may be divided into two categories depending on the spatial scale size of the ionospheric perturbation produced by such effects. For large-scale (> 10 km) perturbations in the ionospheric plasma density, there are changes in the excess time delay for a radio wave signal, which propagates through the ionosphere, while small scale (< 1 m) structures or irregularities in the ionosphere may give rise tok amplitude and phase scintillations on UHF/L-band radio waves, resulting in loss of data, cycle slips and loss of phase lock for signals used in communication/navigation systems. In the equatorial region, where such effects may be severe, space weather effects on the dynamics of equatorial spread F (ESF) irregularities are studied from two different angles. The first one deals with the effect of magnetic activity on the generation of ESF irregularities by helping or hindering the growth of the Rayleigh Taylor (R-T) instability in the post-sunset equatorial F region. For this purpose, spaced receiver observations of scintillations on a UHF signal transmitted from a geostationary satellite and recorded near the dip equator, are used to establish the `age' of the irregularities. This is necessary because the occurrence of scintillations, particularly in the post midnight period, may also be due to irregularities which drift into the path of the radio wave signal, after having been generated more than 3 hours before the actual observation of scintillations. In order to associate the generation of irregularities with major changes in space weather, a parameter that is a measure of random variations in irregularity drift speed is computed from spaced receiver scintillation data. A large value of this parameter is usually a signature of random variations in irregularity drift due to polarization electric fields associated with freshly generated irregularities. Once these electric fields

Reconstruction of F-Region Electric Current Densities from more than 2 Years of Swarm Satellite Magnetic data

NASA Astrophysics Data System (ADS)

Tozzi, R.; Pezzopane, M.; De Michelis, P.; Pignalberi, A.; Siciliano, F.

2016-12-01

The constellation geometry adopted by ESA for Swarm satellites has opened the way to new investigations based on magnetic data. An example is the curl-B technique that allows reconstructing F-region electric current density in terms of its radial, meridional, and zonal components based on data from two satellites of Swarm constellation (Swarm A and B) which fly at different altitudes. Here, we apply this technique to more than 2 years of Swarm magnetic vector data and investigate the average large scale behaviour of F-region current densities as a function of local time, season and different interplanetary conditions (different strength and direction of the three IMF components and/or geomagnetic activity levels).

Temporal and spatial deviation in F2 peak parameters derived from FORMOSAT-3/COSMIC

NASA Astrophysics Data System (ADS)

Kumar, Sanjay; Singh, R. P.; Tan, Eng Leong; Singh, A. K.; Ghodpage, R. N.; Siingh, Devendraa

2016-06-01

The plasma frequency profiles derived from the Constellation of Observing System for Meteorology, Ionosphere and Climate (COSMIC) radio occultation measurements are compared with ground-based ionosonde data during the year 2013. Equatorial and midlatitude five stations located in the Northern and Southern Hemisphere are considered: Jicamarca, Jeju, Darwin, Learmonth, and Juliusruh. The aim is to validate the COSMIC-derived data with ground-based measurements and to estimate the difference in plasma frequency (which represents electron density) and height of F2 layer peak during the daytime/nighttime and during different seasons by comparing the two data sets. Analysis showed that the nighttime data are better correlated than the daytime, and the maximum difference occurs at the equatorial ionospheric anomaly (EIA) station as compared to lower and midlatitude stations during the equinox months. The difference between daytime and nighttime correlations becomes insignificant at midlatitude stations. The statistical analysis of computed errors in foF2 (hmF2) showed Gaussian nature with the most probable error range of ±15% (±10%) at the equatorial and EIA stations, ±9% (±7%) outside the EIA region which reduced to ±8% (±6%) at midlatitude stations. The reduction in error at midlatitudes is attributed to the decrease in latitudinal electron density gradients. Comparing the analyzed data during the three geomagnetic storms and quiet days of the same months, it is observed that the differences are significantly enhanced during storm periods and the magnitude of difference in foF2 increases with the intensity of geomagnetic storm.

Response of nighttime equatorial and low latitude F-region to the geomagnetic storm of August 18, 2003, in the Brazilian sector

NASA Astrophysics Data System (ADS)

Sahai, Y.; Becker-Guedes, F.; Fagundes, P. R.; Lima, W. L. C.; Otsuka, Y.; Huang, C.-S.; Espinoza, E. S.; Pi, X.; de Abreu, A. J.; Bolzan, M. J. A.; Pillat, V. G.; Abalde, J. R.; Pimenta, A. A.; Bittencourt, J. A.

This paper presents an investigation of geomagnetic storm effects in the equatorial and low latitude F-region in the Brazilian sector during the intense geomagnetic storm on 18 August, 2003 (SSC 14:21 UT on 17/08; ΣKp = 52+; Ap = 108; ∣Dst∣ max = 168 at 1600 UT on 18/08). Simultaneous ionospheric sounding measurements from two stations, viz., Palmas (10.2°S, 48.2°W; dip latitude 5.7°S) and Sao Jose dos Campos (23.2°S, 45.9°W; dip latitude 17.6°S), Brazil, are presented for the nights of 16-17, 17-18 and 18-19 August, 2003 (quiet, disturbed and recovery phases). Both stations are equipped with the Canadian Advanced Digital Ionosonde (CADI). Quiet and disturbed conditions of the F-region ionosphere are compared using data collected from the two stations. The relationship between magnetospheric disturbance and low-latitude ionospheric dynamics, and generation of ionospheric irregularities are discussed. On the disturbed nights (17-18 and 18-19 August), the low latitude station S. J. Campos showed strong enhancements in the F-region critical frequency (foF2), whereas the near equatorial station Palmas showed strong uplifting of the F-layer about 1 h earlier. Normally during the June solstice months (May-August) in the Brazilian sector, large-scale ionospheric irregularities in form of plasma bubbles are rarely observed. On the night of 17-18 August, ionsospheric sounding observations at Palmas showed the presence of bottomside spread-F, whereas on the night of 18-19 August, the observations at Palmas and S. J. Campos showed the presence of plasma bubbles when the storm recovery phase had just started. The complementary GPS data available from several stations in the "Rede Brasileira de Monitoramento Continuo de GPS (Brazilian Network for Continuous GPS Monitoring)" are used to obtain the vertical total electron content (VTEC) and the rate of change of TEC per minute on UT days 18 and 19 August, 2003 and presented. Also, several global ionospheric TEC maps

Postoperative plasma 8-iso-prostaglandin F2α levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery.

PubMed

Zheng, Yuan-Bo; Ruan, Guo-Mo; Fu, Jia-Xing; Su, Zhong-Liang; Cheng, Peng; Lu, Jian-Zuo

2016-04-01

Oxidative stress may be involved in occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD). 8-iso-Prostaglandin F2α (8-iso-PGF2α), an isoprostane derived from arachidonic acid via lipid peroxidation, is considered a gold standard for measuring oxidative stress. The present study aimed to investigate the ability of postoperative plasma 8-iso-PGF2α levels to predict POD and POCD in elderly patients undergoing hip fracture surgery. Postoperative plasma 8-iso-PGF2α levels of 182 patients were measured by an enzyme-linked immunosorbent assay. We assessed the relationships between plasma 8-iso-PGF2α levels and the risk of POD and POCD using a multivariate analysis. Plasma 8-iso-PGF2α levels and age were identified as the independent predictors for POD and POCD. Based on areas under receiver operating characteristic curve, the predictive values of 8-iso-PGF2α were obviously higher than those of age for POD and POCD. In a combined logistic-regression model, 8-iso-PGF2α significantly enhanced the areas under curve of age for prediction of POD and POCD. Postoperative plasma 8-iso-PGF2α levels may have the potential to predict POD and POCD in elder patients undergoing hip fracture surgery. Copyright © 2016 Elsevier B.V. All rights reserved.

Infrared spectroscopy of solid normal hydrogen doped with CH3F and O2 at 4.2 K: CH3F:O2 complex and CH3F migration

NASA Astrophysics Data System (ADS)

Abouaf-Marguin, L.; Vasserot, A.-M.

2011-04-01

Double doping of solid normal hydrogen with CH3F and O2 at about 4.2 K gives evidence of (ortho-H2)n:CH3F clusters and of O2:CH3F complex formation. FTIR analysis of the time evolution of the spectra in the region of the v3 C-F stretching mode indicates that these clusters behave very differently from (ortho-H2)n:H2O clusters. The main point is the observed migration of CH3F molecules in solid para-H2 at 4.2 K which differs from that of H2O under identical experimental conditions. This is confirmed by an increase over time of the integrated intensity of the CH3F:O2 complex with a rate constant K = 2.7(2) . 10-4 s-1.

Finite time step and spatial grid effects in δf simulation of warm plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sturdevant, Benjamin J., E-mail: benjamin.j.sturdevant@gmail.com; Department of Applied Mathematics, University of Colorado at Boulder, Boulder, CO 80309; Parker, Scott E.

2016-01-15

This paper introduces a technique for analyzing time integration methods used with the particle weight equations in δf method particle-in-cell (PIC) schemes. The analysis applies to the simulation of warm, uniform, periodic or infinite plasmas in the linear regime and considers the collective behavior similar to the analysis performed by Langdon for full-f PIC schemes [1,2]. We perform both a time integration analysis and spatial grid analysis for a kinetic ion, adiabatic electron model of ion acoustic waves. An implicit time integration scheme is studied in detail for δf simulations using our weight equation analysis and for full-f simulations usingmore » the method of Langdon. It is found that the δf method exhibits a CFL-like stability condition for low temperature ions, which is independent of the parameter characterizing the implicitness of the scheme. The accuracy of the real frequency and damping rate due to the discrete time and spatial schemes is also derived using a perturbative method. The theoretical analysis of numerical error presented here may be useful for the verification of simulations and for providing intuition for the design of new implicit time integration schemes for the δf method, as well as understanding differences between δf and full-f approaches to plasma simulation.« less

Simulated East-west differences in F-region peak electron density at Far East mid-latitude region

NASA Astrophysics Data System (ADS)

Ren, Zhipeng; Zhao, Biqiang; Wan, Weixing; Liu, Libo

2017-04-01

In the present work, using Three-Dimensional Theoretical Ionospheric Model of the Earth in Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME3D-IGGCAS), we simulated the east-west differences in Fregion peak electron density (NmF2) at Far East mid-latitude region.We found that, after removing the longitudinal variations of neutral parameters, TIME3D-IGGCAS can better represent the observed relative east-west difference (Rew) features. Rew is mainly negative (West NmF2 > East NmF2) at noon and positive (East NmF2 >West NmF2) at evening-night. The magnitude of daytime negative Rew is weak at local winter and strong at local summer, and the daytime Rew show two negative peaks around two equinoxes. With the increasing of solar flux level, the magnitude of Rew mainly become larger, and two daytime negative peaks slight shifts to June Solstice. With the decreasing of geographical latitude, Rew mainly become positive, and two daytime negative peaks slight shifts to June Solstice. Our simulation also suggested that the thermospheric zonal wind combined with the geomagnetic field configuration play a pivotal role in the formation of the ionospheric east-west differences at Far East midlatitude region.

Simulated East-west differences in F-region peak electron density at Far East mid-latitude region

NASA Astrophysics Data System (ADS)

Ren, Z.; Wan, W.

2017-12-01

In the present work, using Three-Dimensional Theoretical Ionospheric Model of the Earth in Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME3D-IGGCAS), we simulated the east-west differences in Fregion peak electron density (NmF2) at Far East mid-latitude region.We found that, after removing the longitudinal variations of neutral parameters, TIME3D-IGGCAS can better represent the observed relative east-west difference (Rew) features. Rew is mainly negative (West NmF2 > East NmF2) at noon and positive (East NmF2 >West NmF2) at evening-night. The magnitude of daytime negative Rew is weak at local winter and strong at local summer, and the daytime Rew show two negative peaks around two equinoxes. With the increasing of solar flux level, the magnitude of Rew mainly become larger, and two daytime negative peaks slight shifts to June Solstice. With the decreasing of geographical latitude, Rew mainly become positive, and two daytime negative peaks slight shifts to June Solstice. Our simulation also suggested that the thermospheric zonal wind combined with the geomagnetic field configuration play a pivotal role in the formation of the ionospheric east-west differences at Far East midlatitude region.

Postpartum levels of 8-iso-prostaglandin F2α in plasma and milk phospholipid fractions as biomarker of oxidative stress in first-lactating dairy cows.

PubMed

Vernunft, A; Viergutz, T; Plinski, C; Weitzel, J M

2014-08-01

F2-isoprostanes such as 8-iso-prostaglandin F2 (8-iso-PGF2α) are formed by free radical-catalyzed mechanisms from membrane phospholipids and from low density lipoproteins through peroxidation of arachidonic acid. Esterified 8-iso-PGF2α is cleaved by phospholipases, circulates in blood and is excreted as putatively harmful oxidatively modified lipid via the kidney into urine. In this study we demonstrate that 8-iso-PGF2α concentrations in plasma samples from heifers are higher (p<0.005) compared to those from first-lactating dairy cows at 71 days postpartum. Furthermore, plasma 8-iso-PGF2α concentrations vary with ovarian activity and differ in response to luteolytic initiation as well as activation of the hypothalamic-pituitary-gonadal axis between heifers and first-lactating cows. Sustainable concentrations of 8-iso-PGF2α (50-150 pg/ml) are detectable in the phospholipid fraction of milk, suggesting milk as an additional excretion route for 8-isoprostanes. Plasma levels largely paralleled levels in milk (p<0.001). Plasma phospholipid 8-iso-PGF2α concentrations in cyclic cows decreased (p<0.05) from day 38 to day 71 postpartum, whereas milk phospholipid 8-iso-PGF2α rather increased (p<0.05). Cyclic cows tend to have higher 8-isoprostane levels compared to acyclic animals. In contrast to lipohydroperoxides, concentration of 8-iso-PGF2α were not correlated with milk yield (p>0.05). Our data indicate 8-iso-PGF2α may be a novel biomarker of oxidative stress in dairy cow, which is detectable in blood as well as in milk. Copyright © 2014 Elsevier Inc. All rights reserved.

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.

PubMed

Kowenz-Leutz, Elisabeth; Schuetz, Anja; Liu, Qingbin; Knoblich, Maria; Heinemann, Udo; Leutz, Achim

2016-07-01

The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) regulates cell cycle arrest and terminal differentiation of neutrophils and adipocytes. Mutations in the basic leucine zipper domain (bZip) of C/EBPα are associated with acute myeloid leukemia. A widely used murine transforming C/EBPα basic region mutant (BRM2) entails two bZip point mutations (I294A/R297A). BRM2 has been discordantly described as defective for DNA binding or defective for interaction with E2F. We have separated the two BRM2 mutations to shed light on the intertwined reciprocity between C/EBPα-E2F-DNA interactions. Both, C/EBPα I294A and R297A retain transactivation capacity and interaction with E2F-DP. The C/EBPα R297A mutation destabilized DNA binding, whereas the C/EBPα I294A mutation enhanced binding to DNA. The C/EBPα R297A mutant, like BRM2, displayed enhanced interaction with E2F-DP but failed to repress E2F-dependent transactivation although both mutants were readily suppressed by E2F1 for transcription through C/EBP cis-regulatory sites. In contrast, the DNA binding enhanced C/EBPα I294A mutant displayed increased repression of E2F-DP mediated transactivation and resisted E2F-DP mediated repression. Thus, the efficient repression of E2F dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBPα. Copyright © 2016 Elsevier B.V. All rights reserved.

Characterization of Electron Temperature and Density Profiles of Plasmas Produced by Nike KrF Laser for Laser Plasma Instability (LPI) Research

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Phillips, L.; Obenschain, S. P.; Schmitt, A. J.; Kehne, D. M.; Chan, L.-Y.; Serlin, V.

2011-10-01

Previous experiments with Nike KrF laser (λ = 248 nm , Δν ~ 1 THz) observed LPI signatures near quarter critical density (nc / 4) in CH plasmas, however, detailed measurement of the temperature (Te) and density (ne) profiles was missing. The current Nike LPI campaign will perform experimental determination of the plasma profiles. A side-on grid imaging refractometer (GIR) is the main diagnostic to resolve Te and ne in space taking 2D snapshots of probe laser (λ = 266 nm , Δt = 8 psec) beamlets (50 μm spacing) refracted by the plasma at laser peak time. Ray tracing of the beamlets through hydrodynamically simulated (FASTRAD3D) plasma profiles estimates the refractometer may access densities up to ~ 0 . 2nc . With the measured Te and ne profiles in the plasma corona, we will discuss analysis of light data radiated from the plasmas in spectral ranges relevant to two plasmon decay and convective Raman instabilities. Validity of the (Te ,ne) data will also be discussed for the thermal transport study. Work supported by DoE/NNSA and ONR and performed at NRL.

Relationship between vertical ExB drift and F2-layer characteristics in the equatorial ionosphere at solar minimum conditions

NASA Astrophysics Data System (ADS)

Oyekola, Oyedemi S.

2012-07-01

Equatorial and low-latitude electrodynamics plays a dominant role in determining the structure and dynamics of the equatorial and low-latitude ionospheric F-region. Thus, they constitute essential input parameters for quantitative global and regional modeling studies. In this work, hourly median value of ionosonde measurements namely, peak height F2-layer (hmF2), F2-layer critical frequency (foF2) and propagation factor M(3000)F2 made at near equatorial dip latitude, Ouagadougou, Burkina Faso (12oN, 1.5oW; dip: 1.5oN) and relevant F2-layer parameters such as thickness parameter (Bo), electron temperature (Te), ion temperature (Ti), total electron content (TEC) and electron density (Ne, at the fixed altitude of 300 km) provided by the International Reference Ionosphere (IRI) model for the longitude of Ouagadougou are contrasted with the IRI vertical drift model to explore in detail the monthly climatological behavior of equatorial ionosphere and the effects of equatorial vertical plasma drift velocities on the diurnal structure of F2-layer parameters. The analysis period covers four months representative of solstitial and equinoctial seasonal periods during solar minimum year of 1987 for geomagnetically quiet-day. We show that month-by-month morphological patterns between vertical E×B drifts and F2-layer parameters range from worst to reasonably good and are largely seasonally dependent. A cross-correlation analysis conducted between equatorial drift and F2-layer characteristics yield statistically significant correlations for equatorial vertical drift and IRI-Bo, IRI-Te and IRI-TEC, whereas little or no acceptable correlation is obtained with observational evidence. Assessment of the association between measured foF2, hmF2 and M(3000)F2 illustrates consistent much more smaller correlation coefficients with no systematic linkage. In general, our research indicates strong departure from simple electrodynamically controlled behavior.

Dusty plasma sheath-like structure in the region of lunar terminator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popel, S. I.; Zelenyi, L. M.; Atamaniuk, B.

2015-12-15

The main properties of the dusty plasma layer near the surface over the illuminated and dark parts of the Moon are described. They are used to realize dusty plasma behaviour and to determine electric fields over the terminator region. Possibility of the existence of a dusty plasma sheath-like structure in the region of lunar terminator is shown. The electric fields excited in the terminator region are demonstrated to be on the order of 300 V/m. These electric fields can result in rise of dust particles of the size of 2–3 μm up to an altitude of about 30 cm over the lunar surfacemore » that explains the effect of “horizon glow” observed at the terminator by Surveyor lunar lander.« less

Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon.

PubMed

Shukla, H P; Mason, R P; Bansal, N; Antich, P P

1996-06-01

A novel noninvasive method of measuring local myocardial oxygen tension (pO2) in the perfused rat heart using 19F MRI is demonstrated. Tissue pO2 was determined on the basis of the 19F spin-lattice relaxation rate (R1) of perflubron (perfluorooctyl bromide) sequestered in the heart after IV infusion of an emulsion. Spectroscopic measurement of R1 was previously used to measure a global weighted average of oxygen status. 19F MRI now provides 3D spatial resolution indicating local cardiac pO2 under normally perfused, globally ischemic, and regionally ischemic conditions.

Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys.

PubMed

Gallezot, Jean-Dominique; Esterlis, Irina; Bois, Frederic; Zheng, Ming-Qiang; Lin, Shu-Fei; Kloczynski, Tracy; Krystal, John H; Huang, Yiyun; Sabri, Osama; Carson, Richard E; Cosgrove, Kelly P

2014-11-01

18F-(-)-NCFHEB (also known as 18F-(-)-Flubatine) is a new radioligand to image α4β2* nicotinic acetylcholine receptors in vivo with positron emission tomography (PET), with faster kinetics than previous radioligands such as 18F-2-F-A85380. The goal of this study was to assess the sensitivity of 18F-(-)-NCFHEB-PET to increases in synaptic acetylcholine concentration induced by acetylcholinesterase inhibitors. Two rhesus monkeys were scanned four times each on a Focus 220 scanner: first at baseline, then during two bolus plus infusions of physostigmine (0.06-0.28 mg/kg), and finally following a bolus injection of donepezil (0.25 mg/kg). The arterial input function and the plasma free fraction fP were measured. 18F-(-)-NCFHEB volume of distribution VT was estimated using the multilinear analysis MA1 and then normalized by plasma free fraction fP . 18F-(-)-NCFHEB fP was 0.89±0.04. At baseline, 18F-(-)-NCFHEB VT /fP ranged from 7.9±1.3 mL plasma/cm3 tissue in the cerebellum to 34.3±8.4 mL plasma/cm3 tissue in the thalamus. Physostigmine induced a dose-dependent reduction of 18F-(-)-NCFHEB VT /fP of 34±9% in the putamen, 32±8% in the thalamus, 25±8% in the cortex, and 23±10% in the hippocampus. With donepezil, 18F-(-)-NCFHEB VT /fP was reduced by 24±2%, 14+3% and 14±5%, 10±6% in the same regions. 18F-(-)-NCFHEB can be used to detect changes in synaptic acetylcholine concentration and is a promising tracer to study acetylcholine dynamics with shorter scan durations than previous radioligands. © 2014 Wiley Periodicals, Inc.

Angular dependence of etch rates in the etching of poly-Si and fluorocarbon polymer using SF6, C4F8, and O2 plasmas

NASA Astrophysics Data System (ADS)

Min, Jae-Ho; Lee, Gyeo-Re; Lee, Jin-Kwan; Moon, Sang Heup; Kim, Chang-Koo

2004-05-01

The dependences of etch rates on the angle of ions incident on the substrate surface in four plasma/substrate systems that constitute the advanced Bosch process were investigated using a Faraday cage designed for the accurate control of the ion-incident angle. The four systems, established by combining discharge gases and substrates, were a SF6/poly-Si, a SF6/fluorocarbon polymer, an O2/fluorocarbon polymer, and a C4F8/Si. In the case of SF6/poly-Si, the normalized etch rates (NERs), defined as the etch rates normalized by the rate on the horizontal surface, were higher at all angles than values predicted from the cosine of the ion-incident angle. This characteristic curve shape was independent of changes in process variables including the source power and bias voltage. Contrary to the earlier case, the NERs for the O2/polymer decreased and eventually reached much lower values than the cosine values at angles between 30° and 70° when the source power was increased and the bias voltage was decreased. On the other hand, the NERs for the SF6/polymer showed a weak dependence on the process variables. In the case of C4F8/Si, which is used in the Bosch process for depositing a fluorocarbon layer on the substrate surface, the deposition rate varied with the ion incident angle, showing an S-shaped curve. These characteristic deposition rate curves, which were highly dependent on the process conditions, could be divided into four distinct regions: a Si sputtering region, an ion-suppressed polymer deposition region, an ion-enhanced polymer deposition region, and an ion-free polymer deposition region. Based on the earlier characteristic angular dependences of the etch (or deposition) rates in the individual systems, ideal process conditions for obtaining an anisotropic etch profile in the advanced Bosch process are proposed. .

Experiments Using Local Helicity Injectors in the Lower Divertor Region as the Majority Current Drive in a Tokamak Plasma

NASA Astrophysics Data System (ADS)

Perry, Justin M.

Local helicity injection (LHI) is a non-solenoidal current drive capable of achieving high-Ip tokamak startup with a relatively compact and non-invasive array of current injectors in the plasma scrape-off layer. The choice of injector location within the edge region is flexible, but has a profound influence on the nature of the current drive in LHI discharges. Past experiments on the Pegasus ST with injection on the low-field-side near the outboard midplane produced plasmas dominated by inductive drive resulting primarily from plasma geometry evolution over the discharge. Recent experiments with injection on the high-field- side in the lower divertor region produce plasmas dominated by helicity injection current drive, with relatively static plasma geometry, and thus negligible inductive drive. Plasma current up to 200 kA is driven with helicity injection as the dominant current drive using a pair of 4 cm2 area injectors sourcing 8 kA of total injected current. Steady sustainment with LHI current drive alone is demonstrated, with 100 kA sustained for 18 ms. Maximum achievable plasma current is found to scale approximately linearly with a plasma-geometry- normalized form of the effective loop voltage from LHI, Vnorm = AinjVinj/Rinj, where A inj is the total injector area, Vinj is the injector bias voltage, and Rinj is the major radius of the injectors. A newly-discovered MHD regime for LHI-driven plasmas is described, in which the large-amplitude n = 1 fluctuations at 20-50 kHz which are generally dominant during LHI are abruptly reduced by an order of magnitude on the outboard side. High frequency fluctuations ( f > 400 kHz) increase inside the plasma edge at the same time. This regime results in improved plasma current and pervasive changes to plasma behavior, and may suggest short wavelength turbulence as a current drive mechanism during LHI.

The Osmium(VIII) Oxofluoro Cations OsO(2)F(3)(+) and F(cis-OsO(2)F(3))(2)(+): Syntheses, Characterization by (19)F NMR Spectroscopy and Raman Spectroscopy, X-ray Crystal Structure of F(cis-OsO(2)F(3))(2)(+)Sb(2)F(11)(-), and Density Functional Theory Calculations of OsO(2)F(3)(+), ReO(2)F(3), and F(cis-OsO(2)F(3))(2)(+).

PubMed

Casteel, William J.; Dixon, David A.; Mercier, Hélène P. A.; Schrobilgen, Gary J.

1996-07-17

Osmium dioxide tetrafluoride, cis-OsO(2)F(4), reacts with the strong fluoride ion acceptors AsF(5) and SbF(5) in anhydrous HF and SbF(5) solutions to form orange salts. Raman spectra are consistent with the formation of the fluorine-bridged diosmium cation F(cis-OsO(2)F(3))(2)(+), as the AsF(6)(-) and Sb(2)F(11)(-) salts, respectively. The (19)F NMR spectra of the salts in HF solution are exchange-averaged singlets occurring at higher frequency than those of the fluorine environments of cis-OsO(2)F(4). The F(cis-OsO(2)F(3))(2)(+)Sb(2)F(11)(-) salt crystallizes in the orthorhombic space group Imma. At -107 degrees C, a = 12.838(3) Å, b = 10.667(2) Å, c = 11.323(2) Å, V = 1550.7(8) Å(3), and Z = 4. Refinement converged with R = 0.0469 [R(w) = 0.0500]. The crystal structure consists of discrete fluorine-bridged F(cis-OsO(2)F(3))(2)(+) and Sb(2)F(11)(-) ions in which the fluorine bridge of the F(cis-OsO(2)F(3))(2)(+) cation is trans to an oxygen atom (Os-O 1.676 Å) of each OsO(2)F(3) group. The angle at the bridge is 155.2(8) degrees with a bridging Os---F(b) distance of 2.086(3) Å. Two terminal fluorine atoms (Os-F 1.821 Å) are cis to the two oxygen atoms (Os-O 1.750 Å), and two terminal fluorine atoms of the OsO(2)F(3) group are trans to one another (1.813 Å). The OsO(2)F(3)(+) cation was characterized by (19)F NMR and by Raman spectroscopy in neat SbF(5) solution but was not isolable in the solid state. The NMR and Raman spectroscopic findings are consistent with a trigonal bipyramidal cation in which the oxygen atoms and a fluorine atom occupy the equatorial plane and two fluorine atoms are in axial positions. Density functional theory calculations show that the crystallographic structure of F(cis-OsO(2)F(3))(2)(+) is the energy-minimized structure and the energy-minimized structures of the OsO(2)F(3)(+) cation and ReO(2)F(3) are trigonal bipyramidal having C(2)(v)() point symmetry. Attempts to prepare the OsOF(5)(+) cation by oxidative fluorination of cis

Scintillation and storage luminescence properties of MgF2 transparent ceramics doped with Ce3+

NASA Astrophysics Data System (ADS)

Nakamura, Fumiya; Kato, Takumi; Okada, Go; Kawaguchi, Noriaki; Fukuda, Kentaro; Yanagida, Takayuki

2017-10-01

In this paper, we report basic optical properties and scintillation and storage luminescence properties of MgF2:Ce transparent ceramics with different doping concentrations of Ce (0.01, 0.1 and 1%) synthesized by spark plasma sintering (SPS). In scintillation, thermally-stimulated luminescence (TSL) and optically-stimulated luminescence (OSL), the dominant emissions were due to the 5d-4f transitions of Ce3+ which appeared in the near-UV region peaking around 320 and 360 nm. The scintillation was evaluated by X-ray irradiation while OSL was observed under 540 nm stimulation. In particular, the TSL sensitivity was high and showed a good linearity from 0.1 mGy to 1000 mGy.

Behaviors of Absolute Densities of N, H, and NH3 at Remote Region of High-Density Radical Source Employing N2-H2 Mixture Plasmas

NASA Astrophysics Data System (ADS)

Chen, Shang; Kondo, Hiroki; Ishikawa, Kenji; Takeda, Keigo; Sekine, Makoto; Kano, Hiroyuki; Den, Shoji; Hori, Masaru

2011-01-01

For an innovation of molecular-beam-epitaxial (MBE) growth of gallium nitride (GaN), the measurements of absolute densities of N, H, and NH3 at the remote region of the radical source excited by plasmas have become absolutely imperative. By vacuum ultraviolet absorption spectroscopy (VUVAS) at a relatively low pressure of about 1 Pa, we obtained a N atom density of 9×1012 cm-3 for a pure nitrogen gas used, a H atom density of 7×1012 cm-3 for a gas composition of 80% hydrogen mixed with nitrogen gas were measured. The maximum density 2×1013 cm-3 of NH3 was measured by quadruple mass spectrometry (QMS) at H2/(N2+H2)=60%. Moreover, we found that N atom density was considerably affected by processing history, where the characteristic instability was observed during the pure nitrogen plasma discharge sequentially after the hydrogen-containing plasma discharge. These results indicate imply the importance of establishing radical-based processes to control precisely the absolute densities of N, H, and NH3 at the remote region of the radical source.

Reflection and backscattering of microwaves under doubling of the plasma density and displacement of the gyroresonance region during electron cyclotron resonance heating of plasma in the l-2M stellarator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batanov, G. M.; Borzosekov, V. D.; Vasilkov, D. G.

Reflection and backscattering of high-power (400 kW) gyrotron radiation creating and heating plasma at the second harmonic of the electronic cyclotron frequency in the L-2M stellarator have been investigated experimentally. The effect of the displacement of the gyroresonance region from the axis of the plasma column under doubling of the plasma density on the processes of reflection and backscattering of microwave radiation has been examined. A near doubling of short-wavelength (k{sub ⊥} ≈ 30 cm{sup –1}) turbulent density fluctuations squared is observed. The change in the energy confinement time under variations of plasma parameters and characteristics of short-wavelength turbulence ismore » discussed. A discrepancy between the measured values of the reflection coefficient from the electron cyclotron resonance heating region and predictions of the one-dimensional model is revealed.« less

Molecular formation in the stagnation region of colliding laser-produced plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Shboul, K. F.; Hassan, S. M.; Harilal, S. S.

2016-10-27

The laser-produced colliding plasmas have numerous attractive applications and stagnation layer formed during collisions between plasmas is a useful system for understanding particle collisions and molecular formation in a controlled way. In this article, we explore carbon dimer formation and its evolutionary paths in a stagnation layer formed during the interaction of two laser-produced plasmas. Colliding laser produced plasmas are generated by splitting a laser beam into two sub-beams and then focus them into either a single flat (laterally colliding plasmas) or a V-shaped graphite targets (orthogonally colliding plasmas). The C2 formation in the stagnation region of both colliding plasmamore » schemes is investigated using optical spectroscopic means and compared with emission features from single seed plasma. Our results show that the collisions among the plasmas followed by the stagnation layer formation lead to rapid cooling causing enhanced carbon dimer formation. In addition, plasma electron temperature, density and C2 molecular temperature were measured for the stagnation zone and compared with seed plasma.« less

On Spatial Structuring of the F2 Layer Studied by the Satellite Radio Sounding of the Ionosphere Disturbed by High-Power HF Radio Waves

NASA Astrophysics Data System (ADS)

Tereshchenko, E. D.; Turyansky, V. A.; Khudukon, B. Z.; Yurik, R. Yu.; Frolov, V. L.

2018-01-01

We present the results of studying the characteristics of the artificial plasma structures excited in the ionospheric F2 region modified by high-power HF radio waves. The experiments were carried out at the Sura heating facility using satellite radio sounding of the ionosphere. The plasma density profile was reconstructed with the highest possible spatial resolution for today, about 4 km. In a direction close to the magnetic zenith of the pump wave, the following phenomena were observed: the formation of a cavity with a 15% lower plasma density at the altitudes of the F2 layer and below; the formation of an area with plasma density increased by 12% at altitudes greater than 400 km. With a long-term quasiperiodic impact of the pump wave on the ionosphere, wavy large-scale electron-density perturbations (the meridional scale λx ≈ 130 km and the vertical scale λz ≈ 440 km) are also formed above the Sura facility. These perturbations can be due to the plasma density modulation by an artificial acoustic-gravity wave with a period of 10.6 m, which was formed by the heat source inside a large-scale cavity with low plasma density; there is generation of the electron density irregularities for the electrons with ΔNe/Ne ≈ 3% in the form of layers having the sizes 10-12 km along and about 24 km across the geomagnetic field, which are found both below and above the F2-layer maximum. The mechanisms of the formation of these plasma structures are discussed.

Spherical ion acoustic waves in pair ion plasmas with nonthermal electrons

NASA Astrophysics Data System (ADS)

Selim, M. M.

2016-04-01

Propagation of nonplanar ion acoustic waves in a plasma composed of negative and positive ions and nonthermally distributed electrons is investigated using reductive perturbation theory. The spherical Kadomtsev-Petviashvili (SKP) equation which describes the dynamics of the nonlinear spherical ion acoustic waves is derived. It is found that compressive and rarefactive ion-acoustic solitary wave characteristics significantly depend on the density and mass ratios of the positive to negative ions, the nonthermal electron parameter, and the geometry factor. The possible regions for the existence of spherical ion acoustic waves are defined precisely for typical parameters of (H+, O2 -) and (H+, H-) plasmas in the D and F-regions of the Earth's ionosphere, as well as for laboratory plasma (Ar+, F-).

Detection of Hearing Loss Using 2f2-f1 and 2f1-f2 Distortion-Product Otoacoustic Emissions

ERIC Educational Resources Information Center

Fitzgerald, Tracy S.; Prieve, Beth A.

2005-01-01

Although many distortion-product otoacoustic emissions (DPOAEs) may be measured in the ear canal in response to 2 pure tone stimuli, the majority of clinical studies have focused exclusively on the DPOAE at the frequency 2f1-f2. This study investigated another DPOAE, 2f2-f1, in an attempt to determine the following: (a) the optimal stimulus…

Bulk plasma fragmentation in a C4F8 inductively coupled plasma: A hybrid modeling study

NASA Astrophysics Data System (ADS)

Zhao, Shu-Xia; Zhang, Yu-Ru; Gao, Fei; Wang, You-Nian; Bogaerts, Annemie

2015-06-01

A hybrid model is used to investigate the fragmentation of C4F8 inductive discharges. Indeed, the resulting reactive species are crucial for the optimization of the Si-based etching process, since they determine the mechanisms of fluorination, polymerization, and sputtering. In this paper, we present the dissociation degree, the density ratio of F vs. CxFy (i.e., fluorocarbon (fc) neutrals), the neutral vs. positive ion density ratio, details on the neutral and ion components, and fractions of various fc neutrals (or ions) in the total fc neutral (or ion) density in a C4F8 inductively coupled plasma source, as well as the effect of pressure and power on these results. To analyze the fragmentation behavior, the electron density and temperature and electron energy probability function (EEPF) are investigated. Moreover, the main electron-impact generation sources for all considered neutrals and ions are determined from the complicated C4F8 reaction set used in the model. The C4F8 plasma fragmentation is explained, taking into account many factors, such as the EEPF characteristics, the dominance of primary and secondary processes, and the thresholds of dissociation and ionization. The simulation results are compared with experiments from literature, and reasonable agreement is obtained. Some discrepancies are observed, which can probably be attributed to the simplified polymer surface kinetics assumed in the model.

Atmospheric-pressure plasma jet characterization and applications on melanoma cancer treatment (B/16-F10)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mashayekh, Shahriar; Rajaee, Hajar; Hassan, Zuhir M.

2015-09-15

A new approach in medicine is the use of cold plasma for various applications such as sterilization blood coagulation and cancer cell treatment. In this paper, a pin-to-hole plasma jet for biological applications has been designed and manufactured and characterized. The characterization includes power consumption via Lissajous method, thermal behavior of atmospheric-pressure plasma jet by using Infra-red camera as a novel method and using Speicair software to determine vibrational and transitional temperatures, and optical emission spectroscopy to determine the generated species. Treatment of Melanoma cancer cells (B16/F10) was also implemented, and tetrazolium salt dye (MTT assay) and flow cytometry weremore » used to evaluate viability. Effect of ultraviolet photons on cancerous cells was also observed using an MgF{sub 2} crystal with MTT assay. Finally, in-vivo studies on C57 type mice were also done in order to have a better understanding of the effects in real conditions.« less

The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently

PubMed Central

Coutinho-Budd, Jaeda; Ghukasyan, Vladimir; Zylka, Mark J.; Polleux, Franck

2012-01-01

Summary Coordination of membrane deformation and cytoskeletal dynamics lies at the heart of many biological processes critical for cell polarity, motility and morphogenesis. We have recently shown that Slit-Robo GTPase-activating protein 2 (srGAP2) regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation. Here, we demonstrate that the F-BAR domains of two closely related family members, srGAP1 and srGAP3 [designated F-BAR(1) and F-BAR(3), respectively] display significantly different membrane deformation properties in non-neuronal COS7 cells and in cortical neurons. F-BAR(3) induces filopodia in both cell types, though less potently than F-BAR(2), whereas F-BAR(1) prevents filopodia formation in cortical neurons and reduces plasma membrane dynamics. These three F-BAR domains can heterodimerize, and they act synergistically towards filopodia induction in COS7 cells. As measured by fluorescence recovery after photobleaching, F-BAR(2) displays faster molecular dynamics than F-BAR(3) and F-BAR(1) at the plasma membrane, which correlates well with its increased potency to induce filopodia. We also show that the molecular dynamic properties of F-BAR(2) at the membrane are partially dependent on F-Actin. Interestingly, acute phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] depletion in cells does not interfere with plasma membrane localization of F-BAR(2), which is compatible with our result showing that F-BAR(2) binds to a broad range of negatively-charged phospholipids present at the plasma membrane, including phosphatidylserine (PtdSer). Overall, our results provide novel insights into the functional diversity of the membrane deformation properties of this subclass of F-BAR-domains required for cell morphogenesis. PMID:22467852

Ionospheric modification - An initial report on artificially created equatorial Spread F

NASA Technical Reports Server (NTRS)

Ossakow, S. L.; Zalesak, S. T.; Mcdonald, B. E.

1978-01-01

A numerical simulation code for investigating equatorial Spread F in the collisional Rayleigh-Taylor regime is utilized to follow the evolution of artificial plasma density depletions injected into the bottomside nighttime equatorial F region. The 70 km diameter hole rapidly rises and steepens, forming plasma density enhancements at altitudes below the rising hole. The distribution of enhancements and depletions is similar to natural equatorial Spread F phenomena, except it occurs on a much faster time scale. These predictions warrant carrying out artificial injection experiments in the nighttime equatorial F region.

Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography.

PubMed

Toyama, Hiroshi; Ichise, Masanori; Liow, Jeih-San; Modell, Kendra J; Vines, Douglass C; Esaki, Takanori; Cook, Michelle; Seidel, Jurgen; Sokoloff, Louis; Green, Michael V; Innis, Robert B

2004-08-01

The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMR(glc)) in mice by use of (18)F-FDG and a small animal PET scanner. rCMR(glc) determined with (18)F-FDG PET was compared with values determined simultaneously by the autoradiographic 2-(14)C-DG method. In addition, we compared the rCMR(glc) values under isoflurane, ketamine and xylazine anesthesia, and awake states. Immediately after injection of (18)F-FDG and 2-(14)C-DG into mice, timed arterial samples were drawn over 45 min to determine the time courses of (18)F-FDG and 2-(14)C-DG. Animals were euthanized at 45 min and their brain was imaged with the PET scanner. The brains were then processed for 2-(14)C-DG autoradiography. Regions of interest were manually placed over cortical regions on corresponding coronal (18)F-FDG PET and 2-(14)C-DG autoradiographic images. rCMR(glc) values were calculated for both tracers by the autoradiographic 2-(14)C-DG method with modifications for the different rate and lumped constants for the 2 tracers. Average rCMR(glc) values in cerebral cortex with (18)F-FDG PET under normoglycemic conditions (isoflurane and awake) were generally lower (by 8.3%) but strongly correlated with those of 2-(14)C-DG (r(2) = 0.95). On the other hand, under hyperglycemic conditions (ketamine/xylazine) average cortical rCMR(glc) values with (18)F-FDG PET were higher (by 17.3%) than those with 2-(14)C-DG. Values for rCMR(glc) and uptake (percentage injected dose per gram [%ID/g]) with (18)F-FDG PET were significantly lower under both isoflurane and ketamine/xylazine anesthesia than in the awake mice. However, the reductions of rCMR(glc) were markedly greater under isoflurane (by 57%) than under ketamine and xylazine (by 19%), whereas more marked reductions of %ID/g were observed with ketamine/xylazine (by 54%) than with isoflurane (by 37%). These reverse differences between isoflurane and ketamine/xylazine may be due to

Saturn's E, G, and F rings - Modulated by the plasma sheet?

NASA Technical Reports Server (NTRS)

Morfill, G. E.; Gruen, E.; Johnson, T. V.

1983-01-01

Saturn's broad E ring, the narrow G ring, and the structured and apparently time-variable F ring(s) contain many micron and submicron-sized particles, which make up the 'visible' component. These rings (or ring systems) are in direct contact with magnetospheric plasma. Fluctuations in the plasma density and/or mean energy, due to magnetospheric and solar wind processes, may induce stochastic charge variations on the dust particles, which in turn lead to an orbit perturbation and spatial diffusion. In addition, Coulomb drag forces may be important, in particular for the E ring. The possibility that electromagnetic effects may play a role in determining the F ring structure and its possible time variations is critically examined. Sputtering of micron-sized dust particles in the E ring by magnetospheric ions yields lifetimes of 100 to 10,000 years. This effect as well as the plasma induced transport processes require an active source for the E ring, probably Enceladus.

Oxidative stress in Complex Regional Pain Syndrome (CRPS): no systemically elevated levels of malondialdehyde, F2-isoprostanes and 8OHdG in a selected sample of patients.

PubMed

Fischer, Sigrid G L; Perez, Roberto S G M; Nouta, Jan; Zuurmond, Wouter W A; Scheffer, Peter G

2013-04-10

Exaggerated inflammation and oxidative stress are involved in the pathogenesis of Complex Regional Pain Syndrome (CRPS). However, studies assessing markers for oxidative stress in CRPS patients are limited. In this study, markers for lipid peroxidation (malondialdehyde and F2-isoprostanes) and DNA damage (8-hydroxy-2-deoxyguanosine) were measured in nine patients (mean age 50.1 ± 17.1 years) with short term CRPS-1 (median 3 months) and nine age and sex matched healthy volunteers (mean age 49.3 ± 16.8 years) to assess and compare the level of oxidative stress. No differences were found in plasma between CRPS patients and healthy volunteers for malondialdehyde (5.2 ± 0.9 µmol/L vs. 5.4 ± 0.5 µmol/L) F2-isoprostanes (83.9 ± 18.7 pg/mL vs. 80.5 ± 12.3 pg/mL) and 8-hydroxy-2-deoxyguanosine (92.6 ± 25.5 pmol/L vs. 86.9 ± 19.0 pmol/L). Likewise, in urine, no differences were observed between CRPS patients and healthy volunteers for F2-isoprostanes (117 ng/mmol, IQR 54.5-124.3 vs. 85 ng/mmol, IQR 55.5-110) and 8-hydroxy-2-deoxyguanosine (1.4 ± 0.7 nmol/mmol vs. 1.4 ± 0.5 nmol/mmol). Our data show no elevation of systemic markers of oxidative stress in CRPS patients compared to matched healthy volunteers. Future research should focus on local sampling methods of oxidative stress with adequate patient selection based on CRPS phenotype and lifestyle.

Correcting (18)F-fluoride PET static scan measurements of skeletal plasma clearance for tracer efflux from bone.

PubMed

Siddique, Musib; Frost, Michelle L; Moore, Amelia E B; Fogelman, Ignac; Blake, Glen M

2014-03-01

The aim of the study was to examine whether (18)F-fluoride PET ((18)F-PET) static scan measurements of bone plasma clearance (Ki) can be corrected for tracer efflux from bone from the time of injection. The efflux of tracer from bone mineral to plasma was described by a first-order rate constant kloss. A modified Patlak analysis was applied to 60-min dynamic (18)F-PET scans of the spine and hip acquired during trials on the bone anabolic agent teriparatide to find the best-fit values of kloss at the lumbar spine, total hip and femoral shaft. The resulting values of kloss were used to extrapolate the modified Patlak plots to 120 min after injection and derive a sequence of static scan estimates of Ki at 4-min intervals that were compared with the Patlak Ki values from the 60-min dynamic scans. A comparison was made with the results of the standard static scan analysis, which assumes kloss=0. The best-fit values of kloss for the spine and hip regions of interest averaged 0.006/min and did not change when patients were treated with teriparatide. Static scan values of Ki calculated using the modified analysis with kloss=0.006/min were independent of time between 10 and 120 min after injection and were in close agreement with findings from the dynamic scans. In contrast, by 2 h after injection the static scan Ki values calculated using the standard analysis underestimated the dynamic scan results by 20%. Using a modified analysis that corrects for F efflux from bone, estimates of Ki from static PET scans can be corrected for time up to 2 h after injection. This simplified approach may obviate the need to perform dynamic scans and hence shorten the scanning procedure for the patient and reduce the cost of studies. It also enables reliable estimates of Ki to be obtained from multiple skeletal sites with a single injection of tracer.

Fluorine Kα X-Ray Emission Spectra of MgF2, CaF2, SrF2 and BaF2

NASA Astrophysics Data System (ADS)

Sugiura, Chikara; Konishi, Wataru; Shoji, Shizuko; Kojima, Shinjiro

1990-11-01

The fluorine Kα emission spectra in fluorescence from a series of alkaline-earth fluorides MF2 (M=Mg, Ca, Sr and Ba) are measured with a high-resolution two-crystal vacuum spectrometer. An anomalously low intensity of the K1L1 satellite peak arising from 1s-1(2s2p)-1 initial states is observed for SrF2. The measured emission spectra are presented along with the UPS spectra of the F- 2p valence bands obtained by Poole et al. and the fluorine K absorption-edge spectra by Oizumi et al. By using these spectra, the first peak or shoulder in the fluorine K absorption-edge spectra is identified as being due to a core exciton which is formed below the bottom of the conduction band. The binding energy of the exciton is estimated to be 1.3(± 0.3), 1.1(± 0.2), 1.0(± 0.2) and 1.7(± 0.2) eV for MgF2, CaF2, SrF2 and BaF2, respectively.

Critical frequencies of the ionospheric F1 and F2 layers during the last four solar cycles: Sunspot group type dependencies

NASA Astrophysics Data System (ADS)

Yiǧit, Erdal; Kilcik, Ali; Elias, Ana Georgina; Dönmez, Burçin; Ozguc, Atila; Yurchshyn, Vasyl; Rozelot, Jean-Pierre

2018-06-01

The long term solar activity dependencies of ionospheric F1 and F2 regions' critical frequencies (f0F1 and f0F2) are analyzed for the last four solar cycles (1976-2015). We show that the ionospheric F1 and F2 regions have different solar activity dependencies in terms of the sunspot group (SG) numbers: F1 region critical frequency (f0F1) peaks at the same time with the small SG numbers, while the f0F2 reaches its maximum at the same time with the large SG numbers, especially during the solar cycle 23. The observed differences in the sensitivity of ionospheric critical frequencies to sunspot group (SG) numbers provide a new insight into the solar activity effects on the ionosphere and space weather. While the F1 layer is influenced by the slow solar wind, which is largely associated with small SGs, the ionospheric F2 layer is more sensitive to Coronal Mass Ejections (CMEs) and fast solar winds, which are mainly produced by large SGs and coronal holes. The SG numbers maximize during of peak of the solar cycle and the number of coronal holes peaks during the sunspot declining phase. During solar minimum there are relatively less large SGs, hence reduced CME and flare activity. These results provide a new perspective for assessing how the different regions of the ionosphere respond to space weather effects.

Highly efficient continuous-wave laser operation of LD-pumped Nd,Gd:CaF2 and Nd,Y:CaF2 crystals

NASA Astrophysics Data System (ADS)

Pang, Siyuan; Ma, Fengkai; Yu, Hao; Qian, Xiaobo; Jiang, Dapeng; Wu, Yongjing; Zhang, Feng; Liu, Jie; Xu, Jiayue; Su, Liangbi

2018-05-01

Spectroscopic properties of Nd:CaF2 crystals are investigated. The photoluminescence intensity in the near infrared region is drastically enhanced by co-doping Gd3+ ions and Y3+ in Nd:CaF2 crystals. Preliminary laser experiments are carried out with 0.3%Nd,5%Gd:CaF2 and 0.3%Nd,5%Y:CaF2 crystals under laser diode pumping; true continuous wave laser operation is achieved with slope efficiencies of 42% and 39%, respectively, and the maximum output power reaches 1.188 W.

Elevated plasma 8-iso-prostaglandin F2α levels in human smokers originate primarily from enzymatic instead of non-enzymatic lipid peroxidation.

PubMed

van 't Erve, Thomas J; Lih, Fred B; Kadiiska, Maria B; Deterding, Leesa J; Mason, Ronald P

2018-02-01

It is widely accepted that free radicals in tobacco smoke lead to oxidative stress and generate the popular lipid peroxidation biomarker 8-iso-prostaglandin F 2α (8-iso-PGF 2α ). However, 8-iso-PGF 2α can simultaneously be produced in vivo by the prostaglandin-endoperoxide synthases (PGHS) induced by inflammation. This inflammation-dependent mechanism has never been considered as a source of elevated 8-iso-PGF 2α in tobacco smokers. The goal of this study is to quantify the distribution of chemical- and PGHS-dependent 8-iso-PGF 2α formation in the plasma of tobacco smokers and non-smokers. The influences of gender and hormonal contraceptive use were accounted for. The distribution was determined by measuring the 8-iso-PGF 2α /prostaglandin F 2α (PGF 2α ) ratio. When comparing smokers (n = 28) against non-smokers (n = 30), there was a statistically significant increase in the 8-iso-PGF 2α concentration. The source of this increased 8-iso-PGF 2α was primarily from PGHS. When stratifying for gender, the increase in 8-iso-PGF 2α in male smokers (n = 9) was primarily from PGHS. Interestingly, female smokers on hormonal contraceptives had increased 8-iso-PGF 2α in both pathways, whereas those not on hormonal contraceptives did not have increased 8-iso-PGF 2α . In conclusion, increased plasma 8-iso-PGF 2α in tobacco smokers has complex origins, with PGHS-dependent formation as the primary source. Accounting for both pathways provides a definitive measurement of both oxidative stress and inflammation. Published by Elsevier Inc.

Characteristics of laser produced plasmas of hafnium and tantalum in the 1-7 nm region

NASA Astrophysics Data System (ADS)

Li, Bowen; Otsuka, Takamitsu; Sokell, Emma; Dunne, Padraig; O'Sullivan, Gerry; Hara, Hiroyuki; Arai, Goki; Tamura, Toshiki; Ono, Yuichi; Dinh, Thanh-Hung; Higashiguchi, Takeshi

2017-11-01

Soft X-ray (SXR) spectra from hafnium and tantalum laser produced plasmas were recorded in the 1-7 nm region using two Nd:YAG lasers with pulse lengths of 170 ps and 10 ns, respectively, operating at a range of power densities. The maximum focused peak power density was 2. 3 × 1014 W cm-2 for 170 ps pulses and 1. 8 × 1012 W cm-2 for 10 ns pulses, respectively. Two intense quasicontinuous intensity bands resulting from n = 4 - n = 4 and n = 4 - n = 5 unresolved transition arrays (UTAs) dominate both sets of experimental spectra. Comparison with calculations performed with the Cowan suite of atomic structure codes as well as consideration of previous experimental and theoretical results aided identification of the most prominent features in the spectra. For the 10 ns spectrum, the highest ion stage that could be identified from the n = 4 - n = 5 arrays were lower than silver-like Hf25+ and Ta26+ (which has a 4 d 104 f ground configuration) indicating that the plasma temperature attained was too low to produce ions with an outermost 4 d subshell, while for the 170 ps plasmas the presence of significantly higher stages was deduced and lines due to 4 d-5 p transitions were clearly evident. Furthermore, we show an enhancement of emission from tantalum using dual laser irradiation, and the effect of pre-pulse durations and delay times between two pulses are demonstrated.

Hollow Cathode and Keeper-region Plasma Measurements Using Ultra-fast Miniature Scanning Probes

NASA Technical Reports Server (NTRS)

Goebel, Dan M.; Jameson, Kristina K.; Watkins, Ron M.; Katz, Ira

2004-01-01

In order to support the development of comprehensive performance and life models for future deep space missions that will utilize ion thrusters, we have undertaken a study of the plasma structure in hollow cathodes using an new pneumatic scanning probe diagnostic. This device is designed to insert a miniature probe directly into the hollow cathode orifice from either the upstream insert region in the interior of the hollow cathode, or from the downstream keeper-plasma region at the exit of the hollow cathode, to provide complete axial profiles of the discharge plasma parameters. Previous attempts to diagnose this region with probes was Limited by the melting of small probes in the intense discharge near the orifice, or caused significant perturbation of the plasma by probes large enough to survive. Our new probe is extremely compact, and when configured as a single Langmuir probe, the ceramic tube insulator is only 0.5mm in diameter and the current collecting conductor has a total area of 0.002 cm2. A series of current-voltage characteristics are obtained by applying a rapid sawtooth voltage waveform to the probe as it is scanned by the pneumatic actuator into and out of the plasma region, The bellow-sealed pneumatic drive scans the probe 4 cm in the cathode insert region and 10 cm in the anode/keeper plasmas region at average speeds of about 1 mm/msec, and the residence time at the end of the insertion stroke in the densest part of the plasma near the orifice is measured to be only 10 msec. Since the voltage sweep time is fast compared to the motion of the probe, axial profiles of the plasma density, temperature and potential with reasonable spatial resolution are obtained. Measurements of the internal cathode pressures and the axial plasma-parameter profiles for a hollow cathode operating at discharge currents of up to 35 A in xenon will be presented.

Diurnal evolution of the F region electron density local time gradient at low and middle latitudes resolved by the Swarm constellation

NASA Astrophysics Data System (ADS)

Xiong, Chao; Zhou, Yun-Liang; Lühr, Hermann; Ma, Shu-Ying

2016-09-01

In this study we have provided new insights into the local time gradient of F region electron density (ΔNe) derived from the lower pair of Swarm satellites flying side by side. Our result shows that the electron density (Ne) increase starts just at sunrise, around 06:00 LT, simultaneously at low and middle latitudes due to the increased photoionization. At equatorial latitudes the increase in electron density gets even steeper after 07:00 LT, and the steepest increase of electron density (about 3 · 1010 m-3 within 6 min) occurs around 09:00 LT. We suggest that the upward vertical plasma drift in connection with the buildup of the equatorial fountain effect plays a major role. We also found that the local time variations of the equatorial ionization anomaly (EIA) crest electron density during daytime are similar to the respective evolutions at the equator, but about 1-2 h delayed. We relate this delay to the response time between the equatorial electric field and the buildup of the plasma fountain. At equinox months a fast decrease of the F region electron density is seen at the EIA trough region during the prereversal enhancement, while an increase is found meanwhile at crest regions. Afterward, a fast decrease of the EIA crest electron density occurs between 19:00 and 23:00 LT, with seasonal dependence. The local time gradient between Swarm A and C shows also prominent longitudinal wave-4 pattern around August months, and the phase of DE3 in ΔNe is found to be delayed by 6 h compared to that in Ne.

Influence of the St. Patrick's Day geomagnetic storm on the mid-latitude E and F regions.

NASA Astrophysics Data System (ADS)

Garnett Marques Brum, C.; Raizada, S.; Hajra, R.; Echer, E.

2016-12-01

We will discuss the impact of St. Patrick's Day geomagnetic storm that occurred between 17 -19 March 2015 on the E and F-region of the ionosphere. During the initial phase of this event the foF2 increases about 3 MHz in respect to the quiet period followed by a sharp decrease in foF2 values of about 10 MHz, reaching -6 MHz in the end of the main phase (Dst dropped to -225 nT on 17th March) as observed using Incoherent Scatter Radar and ionosonde located in Puerto Rico. However, during the rest of the disturbance, the F-region showed an increase in the electron concentration, in particular during the nighttime periods. Large fluctuations were observed in hmF2 with variations up to 150 km relative to quiet time period. This paper will also investigate the coupling between high and mid latitudes along with E and F region of the ionosphere over Arecibo.

2.4 μm diode-pumped Dy2+:CaF2 laser

NASA Astrophysics Data System (ADS)

Švejkar, Richard; Papashvili, Alexander G.; Šulc, Jan; Němec, Michal; Jelínková, Helena; Doroshenko, Maxim E.; Batygov, Sergei H.; Osiko, Vyacheslav V.

2018-01-01

In this work, a cryogenic cooled, longitudinal diode-pumped Dy2+ :CaF2 laser was investigated for the first time. The temperature dependence of the spectroscopy and the laser properties of Dy2+ :CaF2 are presented. The tested Dy2+ :CaF2 crystal was a longitudinal pump in a near-IR region (926 nm) by laser diode radiation. The maximal mean output power and slope efficiency at 78 K during the pulse regime of the laser were 57.5 mW and 7%, respectively. Furthermore, the CW regime was successfully tested and a maximum output power of 0.37 W was obtained for the absorbed pumping power 5.7 W. The emission laser wavelength was 2367 nm.

Does High Plasma-β Dynamics ``Load'' Active Regions?

NASA Astrophysics Data System (ADS)

McIntosh, Scott W.

2007-03-01

Using long-duration observations in the He II 304 Å passband of SOHO EIT, we investigate the spatial and temporal appearance of impulsive intensity fluctuations in the pixel light curves. These passband intensity fluctuations come from plasma emitting in the chromosphere, in the transition region, and in the lowest portions of the corona. We see that they are spatially tied to the supergranular scale and that their rate of occurrence is tied to the unsigned imbalance of the magnetic field in which they are observed. The signature of the fluctuations (in space and time) is consistent with their creation by magnetoconvection-forced reconnection, which is driven by the flow field in the high-β plasma. The signature of the intensity fluctuations around an active region suggests that the bulk of the mass and energy going into the active region complex observed in the hotter coronal plasma is supplied by this process, dynamically forcing the looped structure from beneath.

Surface Phenomena During Plasma-Assisted Atomic Layer Etching of SiO2.

PubMed

Gasvoda, Ryan J; van de Steeg, Alex W; Bhowmick, Ranadeep; Hudson, Eric A; Agarwal, Sumit

2017-09-13

Surface phenomena during atomic layer etching (ALE) of SiO 2 were studied during sequential half-cycles of plasma-assisted fluorocarbon (CF x ) film deposition and Ar plasma activation of the CF x film using in situ surface infrared spectroscopy and ellipsometry. Infrared spectra of the surface after the CF x deposition half-cycle from a C 4 F 8 /Ar plasma show that an atomically thin mixing layer is formed between the deposited CF x layer and the underlying SiO 2 film. Etching during the Ar plasma cycle is activated by Ar + bombardment of the CF x layer, which results in the simultaneous removal of surface CF x and the underlying SiO 2 film. The interfacial mixing layer in ALE is atomically thin due to the low ion energy during CF x deposition, which combined with an ultrathin CF x layer ensures an etch rate of a few monolayers per cycle. In situ ellipsometry shows that for a ∼4 Å thick CF x film, ∼3-4 Å of SiO 2 was etched per cycle. However, during the Ar plasma half-cycle, etching proceeds beyond complete removal of the surface CF x layer as F-containing radicals are slowly released into the plasma from the reactor walls. Buildup of CF x on reactor walls leads to a gradual increase in the etch per cycle.

Photoluminescence properties of Eu3+ doped HfO2 coatings formed by plasma electrolytic oxidation of hafnium

NASA Astrophysics Data System (ADS)

Stojadinović, Stevan; Tadić, Nenad; Ćirić, Aleksandar; Vasilić, Rastko

2018-03-01

Plasma electrolytic oxidation was used for synthesis of Eu3+ doped monoclinic HfO2 coatings on hafnium substrate. Results of photoluminescence (PL) measurements show the existence of two distinct regions: one that is related to the blue emission originating from oxygen vacancy defects in HfO2 and the other one characterized with a series of sharp orange-red emission peaks related to f-f transitions of Eu3+ from excited level 5D0 to lower levels 7FJ (J = 0, 1, 2, 3, and 4). PL peaks appearing in excitation spectra of obtained coatings are attributed either to charge transfer state of Eu3+ or to direct excitation of the Eu3+ ground state 7F0 into higher levels of the 4f-manifold. PL of formed coatings increases with PEO time due to an increase of oxygen vacancy defects and the content of Eu3+. Acquired experimental data suggest that hypersensitive electrical dipole transition is much more intense than the magnetic dipole transition, indicating that Eu3+ ions occupy a non-inversion symmetry sites.

The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis

PubMed Central

Marlowe, Jennifer L.; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S.; Xia, Ying

2008-01-01

Cellular stress by DNA damage induces checkpoint kinase-2 (CHK2)-mediated phosphorylation and stabilization of the E2F1 transcription factor, leading to induction of apoptosis by activation of a subset of proapoptotic E2F1 target genes, including Apaf1 and p73. This report characterizes an interaction between the aryl hydrocarbon (Ah) receptor (AHR), a ligand-activated transcription factor, and E2F1 that results in the attenuation of E2F1-mediated apoptosis. In Ahr−/− fibroblasts stably transfected with a doxycycline-regulated AHR expression vector, inhibition of AHR expression causes a significant elevation of oxidative stress, γH2A.X histone phosphorylation, and E2F1-dependent apoptosis, which can be blocked by small interfering RNA-mediated knockdown of E2F1 expression. In contrast, ligand-dependent AHR activation protects these cells from etoposide-induced cell death. In cells expressing both proteins, AHR and E2F1 interact independently of the retinoblastoma protein (RB), because AHR and E2F1 coimmunoprecipitate from extracts of RB-negative cells. Additionally, chromatin immunoprecipitation assays indicate that AHR and E2F1 bind to the Apaf1 promoter at a region containing a consensus E2F1 binding site but no AHR binding sites. AHR activation represses Apaf1 and TAp73 mRNA induction by a constitutively active CHK2 expression vector. Furthermore, AHR overexpression blocks the transcriptional induction of Apaf1 and p73 and the accumulation of sub-G0/G1 cells resulting from ectopic overexpression of E2F1. These results point to a proproliferative, antiapoptotic function of the Ah receptor that likely plays a role in tumor progression. PMID:18524851

F region above Kauai - Measurement, model, modification

NASA Technical Reports Server (NTRS)

Johnson, C. Y.; Sjolander, G. W.; Oran, E. S.; Young, T. R.; Bernhardt, P. A.; Da Rosa, A. V.

1980-01-01

Results of the Lagopedo II experiment conducted from Kauai, Hawaii to investigate the ionospheric modification that occurs when rocket combustion products are introduced into the O(+)-rich F region are presented. The experiment involved the detonation of a chemical explosion in the F2 peak accompanied by rocket-borne measurements of ion composition and electron content in the vicinity of the explosion. The experimental data is found to be in good agreement with the predictions of a model of the nighttime ion densities in the midlatitude laminar ionosphere, with the exception of N2(+) densities before the explosion. H2O(+) and H3O(+) currents produced by considerable H2O outgassing from the rocket are used to determine a H3O(+)/H2O(+) dissociative recombination rate averaging 1.6 to 1.08, depending on model assumptions. At the time of the explosion, an ionic void 1 km in radius is observed, the boundary of which is characterized by a steep gradient in ionic densities. Evidence of variations in the concentrations of ambient ion species, new reactant species and ionic depletion by sweeping is also obtained.

Measurement of cytoplasmic Ca2+ concentration in Saccharomyces cerevisiae induced by air cold plasma

NASA Astrophysics Data System (ADS)

Xiaoyu, DONG

2018-03-01

In this study, a novel approach to measure the absolute cytoplasmic Ca2+ concentration ([Ca2+]cyt) using the Ca2+ indicator fluo-3 AM was established. The parameters associated with the probe fluo-3 AM were optimized to accurately determine fluorescence intensity from the Ca2+-bound probe. Using three optimized parameters (final concentration of 6 mM probe, incubation time of 135 min, loading probe before plasma treatment), the maximum fluorescence intensity (F max = 527.8 a.u.) and the minimum fluorescence intensity (F min = 63.8 a.u.) were obtained in a saturated Ca2+ solution or a solution of lacking Ca2+. Correspondingly, the maximum [Ca2+]cyt induced by cold plasma was 1232.5 nM. Therefore, the Ca2+ indicator fluo-3 AM was successfully applied to measure the absolute [Ca2+]cyt in Saccharomyces cerevisiae stimulated by cold plasma at atmospheric air pressure.

Relation Between Magnetospheric State Parameters and the Occurrence of Plasma Depletion Events in the Nighttime Midlatitude F Region

NASA Technical Reports Server (NTRS)

Seker, Ilgin; Fung, Shing F.; Mathews, John D.

2011-01-01

Studies using all-sky imagers have revealed the presence of various ionospheric irregularities in the nighttime midlatitude F region. The most prevalent and well known of these are the medium-scale traveling ionospheric disturbances (MSTIDs) that usually occur when the geomagnetic activity is low and midlatitude spread F plumes that are often observed when the geomagnetic activity is high. The inverse and direct relations between geomagnetic activity and the occurrence rate of MSTIDs and midlatitude plumes, respectively, have been observed by several studies using different instruments; however, most of them focus on MSTIDs only and use only Kp to characterize geomagnetic activity. In order to understand the underlying causes of these two relations and to distinguish between MSTIDs and plumes, it is illuminating to better characterize the occurrence of MSTIDs and plumes using multiple magnetospheric state parameters. Here we statistically compare multiple geomagnetic driver and response parameters (such as Kp, AE, Dst, and solar wind parameters) with the occurrence rates of nighttime MSTIDs and plumes observed using an all ]sky imager at Arecibo Observatory (AO) between 2003 and 2008. We also present seasonal and annual variations of MSTIDs and plumes at AO. The results not only allow us to better distinguish MSTIDs and plumes, but also to shed further light on the generation mechanism and electrodynamics of these two different phenomena occurring at nighttime in the midlatitude F region.

Measurement of Laser Plasma Instability (LPI) Driven Light Scattering from Plasmas Produced by Nike KrF Laser

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Phillips, L.; Obenschain, S. P.; Schmitt, A. J.; Kehne, D. M.; Serlin, V.; Lehmberg, R. H.; McLean, E. A.; Manka, C. K.

2010-11-01

With short wavelength (248 nm), large bandwidth (1˜3 THz), and ISI beam smoothing, Nike KrF laser provides unique research opportunities and potential for direct-drive inertial confinement fusion. Previous Nike experiments observed two plasmon decay (TPD) driven signals from CH plasmas at the laser intensities above ˜2x10^15 W/cm^2 with total laser energies up to 1 kJ of ˜350 ps FWHM pulses. We have performed a further experiment with longer laser pulses (0.5˜4.0 ns FWHM) and will present combined results of the experiments focusing on light emission data in spectral ranges relevant to the Raman (SRS) and TPD instabilities. Time- or space-resolved spectral features of TPD were detected at different viewing angles and the absolute intensity calibrated spectra of thermal background were used to obtain blackbody temperatures in the plasma corona. The wave vector distribution in k-space of the participating TPD plasmons will be also discussed. These results show promise for the proposed direct-drive designs.

Aspect sensitive E- and F-region SPEAR-enhanced incoherent backscatter observed by the EISCAT Svalbard radar

NASA Astrophysics Data System (ADS)

Dhillon, R. S.; Robinson, T. R.; Yeoman, T. K.

2009-01-01

Previous studies of the aspect sensitivity of heater-enhanced incoherent radar backscatter in the high-latitude ionosphere have demonstrated the directional dependence of incoherent scatter signatures corresponding to artificially excited electrostatic waves, together with consistent field-aligned signatures that may be related to the presence of artificial field-aligned irregularities. These earlier high-latitude results have provided motivation for repeating the investigation in the different geophysical conditions that obtain in the polar cap ionosphere. The Space Plasma Exploration by Active Radar (SPEAR) facility is located within the polar cap and has provided observations of RF-enhanced ion and plasma line spectra recorded by the EISCAT Svalbard UHF incoherent scatter radar system (ESR), which is collocated with SPEAR. In this paper, we present observations of aspect sensitive E- and F-region SPEAR-induced ion and plasma line enhancements that indicate excitation of both the purely growing mode and the parametric decay instability, together with sporadic E-layer results that may indicate the presence of cavitons. We note consistent enhancements from field-aligned, vertical and also from 5° south of field-aligned. We attribute the prevalence of vertical scatter to the importance of the Spitze region, and of that from field-aligned to possible wave/irregularity coupling.

Plasma observations near saturn: initial results from voyager 2.

PubMed

Bridge, H S; Bagenal, F; Belcher, J W; Lazarus, A J; McNutt, R L; Sullivan, J D; Gazis, P R; Hartle, R E; Ogilvie, K W; Scudder, J D; Sittler, E C; Eviatar, A; Siscoe, G L; Goertz, C K; Vasyliunas, V M

1982-01-29

Results of measurements of plasma electrons and poitive ions made during the Voyager 2 encounter with Saturn have been combined with measurements from Voyager 1 and Pioneer 11 to define more clearly the configuration of plasma in the Saturnian magnetosphere. The general morphology is well represented by four regions: (i) the shocked solar wind plasma in the magnetosheath, observed between about 30 and 22 Saturn radii (RS) near the noon meridian; (ii) a variable density region between approximately 17 RS and the magnetopause; (iii) an extended thick plasma sheet between approximately 17 and approximately 7 RS symmetrical with respect to Saturn's equatorial plane and rotation axis; and (iv) an inner plasma torus that probably originates from local sources and extends inward from L approximately 7 to less than L approximately 2.7 (L is the magnetic shell parameter). In general, the heavy ions, probably O(+), are more closely confined to the equatorial plane than H(+), so that the ratio of heavy to light ions varies along the trajectory according to the distance of the spacecraft from the equatorial plane. The general configuration of the plasma sheet at Saturn found by Voyager 1 is confirmed, with some notable differences and additions. The "extended plasma sheet," observed between L approximately 7 and L approximately 15 by Voyager 1 is considerably thicker as observed by Voyager 2. Inward of L approximately 4, the plasma sheet collapses to a thin region about the equatorial plane. At the ring plane crossing, L approximately 2.7, the observations are consistent with a density of O(+) of approximately 100 per cubic centimeter, with a temperature of approximately 10 electron volts. The location of the bow shock and magnetopause crossings were consistent with those previously observed. The entire magnetosphere was larger during the outbound passage of Voyager 2 than had been previously observed; however, a magnetosphere of this size or larger is expected approximately 3

Investigation of the 2f1-f2 and 2f2-f1 distortion product otoacoustic emissions using a computational model of the gerbil ear.

PubMed

Wen, Haiqi; Bowling, Thomas; Meaud, Julien

2018-05-19

In this work, a three-dimensional computational model of the gerbil ear is used to investigate the generation of the 2f 1 -f 2 and 2f 2 -f 1 distortion product otoacoustic emissions (DPOAEs). In order to predict both the distortion and reflection sources, cochlear roughness is modeled by introducing random inhomogeneities in the outer hair cell properties. The model was used to simulate the generation of DPOAEs in response to a two-tone stimulus for various primary stimulus levels and frequency ratios. As in published experiments, the 2f 1 -f 2 DPOAEs are mostly dominated by the distortion component while the 2f 2 -f 1 DPOAEs are dominated by the reflection component; furthermore, the influence of the levels and frequency ratio of the primaries are consistent with measurements. Analysis of the intracochlear response shows that the distortion component has the highest magnitude at all longitudinal locations for the 2f 1 -f 2 distortion product (DP) while the distortion component only dominates close to the DP best place in the case of the 2f 2 -f 1 DP. Decomposition of the intracochlear DPs into forward and reverse waves demonstrates that the 2f 1 -f 2 DP generates reverse waves for both the distortion and reflection components; however, a reverse wave is only generated for the reflection component in the case of the 2f 2 -f 1 DP. As in experiments in the gerbil, the group delay of the reflection component of the DPOAE is between 1× and 2× the forward group delay, which is consistent with the propagation of DP towards the stapes as slow reverse waves. Copyright © 2018 Elsevier B.V. All rights reserved.

Proton irradiation of [18O]O2: production of [18F]F2 and [18F]F2 + [18F] OF2.

PubMed

Bishop, A; Satyamurthy, N; Bida, G; Hendry, G; Phelps, M; Barrio, J R

1996-04-01

The production of 18F electrophilic reagents via the 18O(p,n)18F reaction has been investigated in small-volume target bodies made of aluminum, copper, gold-plated copper and nickel, having straight or conical bore shapes. Three irradiation protocols-single-step, two-step and modified two-step-were used for the recovery of the 18F activity. The single-step irradiation protocol was tested in all the target bodies. Based on the single-step performance, aluminum targets were utilized extensively in the investigation of the two-step and modified two-step irradiation protocols. With an 11-MeV cyclotron and using the two-step irradiation protocol, > 1Ci [18F]F2 was recovered reproducibly from an aluminum target body. Probable radical mechanisms for the formation of OF2 and FONO2 (fluorine nitrate) in the single-step and modified two-step targets are proposed based on the amount of ozone generated and the nitrogen impurity present in the target gases, respectively.

Auroral kilometric radiation: Wave modes, harmonic and source region electron density structures

NASA Technical Reports Server (NTRS)

Benson, R. F.

1984-01-01

A change from extraordinary (X) mode to ordinary (0) mode dominance is observed in the auroral kilometric radiation (AKR) detected on ISIS 1 topside sounder ionograms as the source region plasma to gyrofrequency ratio fN/fH varies from 0.1 to 1.3. The X and 0 mode AKR, Z (the slow branch of the X mode) and whistler (W) mode are also observed. The Z mode is typically slightly less intense than the 0-mode. Thw W-mode is confined to frequencies less than fH/2, suggesting that it is the result of field aligned ducted signals reaching the satellite from a source at lower altitudes. Harmonic AKR bands are commonly observed and the 2nd harmonic appears to be due to propagating signals. The deduced (fN/fH) at the bottom of the AKR source region is always less than 0.4 and is typically less than 0.2 during the generation of X-mode AKR, but approaches 0.9 for 0-mode AKR. No large density enhancements were observed within AKR source region density cavities. It is suggested that the observed INTENSE AKR IS cyclotron X-mode radiation rather than plasma frequency 0-mode radiation.

Plasma currents and anisotropy in the tail-dipole transition region

NASA Astrophysics Data System (ADS)

Artemyev, A.; Zhang, X. J.; Angelopoulos, V.; Runov, A.

2017-12-01

Using conjugated THEMIS and Van Allen Probes observations in the nightside magnetosphere, we examine statistically plasma and magnetic field characteristics at multiple locations simultaneously across the 3-10 RE region (i.e., across the tail-dipole transition region, whose location depends on tail flux loading and the strength of global convection). We find that the spatial distributions of ion and electron anisotropies vary significantly but systematically with radial distance and geomagnetic activity. For low Kp (<2), ions are transversely anisotropic near Earth but isotropic in the tail, whereas electrons are isotropic closer to Earth but field-aligned in tail. For large Kp (>4), the anisotropy profiles for ions and electrons reverse: ions are isotropic closer to the Earth and field-aligned in the tail, whereas electrons are transversely anisotropic closer to Earth but isotropic in the tail. Using the measured plasma anisotropy radial profiles we estimate the currents from curvature drifts and compare them with diamagnetic currents. We also discuss the implications of the observed plasma anisotropies for the presence and spatial distribution of field-aligned electric fields.

The response of plasma density to breaking inertial gravity wave in the lower regions of ionosphere

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, Wenbo, E-mail: Wenbo.Tang@asu.edu; Mahalov, Alex, E-mail: Alex.Mahalov@asu.edu

2014-04-15

We present a three-dimensional numerical study for the E and lower F region ionosphere coupled with the neutral atmosphere dynamics. This model is developed based on a previous ionospheric model that examines the transport patterns of plasma density given a prescribed neutral atmospheric flow. Inclusion of neutral dynamics in the model allows us to examine the charge-neutral interactions over the full evolution cycle of an inertial gravity wave when the background flow spins up from rest, saturates and eventually breaks. Using Lagrangian analyses, we show the mixing patterns of the ionospheric responses and the formation of ionospheric layers. The correspondingmore » plasma density in this flow develops complex wave structures and small-scale patches during the gravity wave breaking event.« less

Semiannual and solar activity variations of daytime plasma observed by DEMETER in the ionosphere-plasmasphere transition region

NASA Astrophysics Data System (ADS)

Li, L. Y.; Cao, J. B.; Yang, J. Y.; Berthelier, J. J.; Lebreton, J.-P.

2015-12-01

Using the plasma data of Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions (DEMETER) satellite and the NRLMSISE-00 atmospheric model, we examined the semiannual and solar activity variations of the daytime plasma and neutral composition densities in the ionosphere-plasmasphere transition region (~670-710 km). The results demonstrate that the semiannually latitudinal variation of the daytime oxygen ions (O+) is basically controlled by that of neutral atomic oxygen (O), whereas the latitude distributions of the helium and hydrogen ions (He+ and H+) do not fully depend on the neutral atomic helium (He) and hydrogen (H). The summer enhancement of the heavy oxygen ions is consistent with the neutral O enhancement in the summer hemisphere, and the oxygen ion density has significantly the summer-dense and winter-tenuous hemispheric asymmetry with respect to the dip equator. Although the winter enhancements of the lighter He+ and H+ ions are also associated with the neutral He and H enhancements in the winter hemisphere, the high-density light ions (He+ and H+) and electrons (e-) mainly appear at the low and middle magnetic latitudes (|λ| < 50°). The equatorial accumulations of the light plasma species indicate that the light charged particles (He+, H+, and e-) are easily transported by some equatorward forces (e.g., the magnetic mirror force and centrifugal force). The frequent Coulomb collisions between the charged particles probably lead to the particle trappings at different latitudes. Moreover, the neutral composition densities also influence their ion concentrations during different solar activities. From the low-F10.7 year (2007-2008) to the high-F10.7 year (2004-2005), the daytime oxygen ions and electrons increase with the increasing neutral atomic oxygen, whereas the daytime hydrogen ions tend to decrease with the decreasing neutral atomic hydrogen. The helium ion density has no obvious solar activity variation, suggesting that the

Changes in regional plasma extravasation in rats following endotoxin infusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

van Lambalgen, A.A.; van den Bos, G.C.; Thijs, L.G.

Regional differences in plasma extravasation during endotoxin shock in rats and a possible relationship with changes in regional blood flow were studied with radioactive isotopes (/sup 125/I-HSA, 51Cr-labeled red blood cells, microspheres) in anesthetized rats (pentobarbital). Shock was induced by intravenous infusion of endotoxin (Eschericia coli; 10 mg X kg-1) for 60 min (starting at t = 0); at t = 120 min, the experiments were terminated. These rats (n = 8) were compared with time-matched control rats (n = 8). A third group (rats killed 7.5 min after injection of /sup 125/I-HSA, i.e., no extravasation; n = 8) servedmore » as baseline. The amount of plasma extravasated in 2 hr of endotoxin shock was significantly increased over control values in skin (by 67%), colon (88%), skeletal muscle (105%), stomach (230%), pancreas (300%), and diaphragm (1300%). Losses of /sup 125/I-HSA into intestinal lumen and peritoneal cavity had also increased over control values by 146 and 380%, respectively. Blood flow was compromised in most organs except heart and diaphragm. Extravasation when normalized for total plasma supply was correlated with total blood supply; the more the blood supply decreased, the higher the normalized extravasation. In the diaphragm, however, blood supply and plasma leakage increased together. Decreased blood supply and plasma extravasation may be related but they could also be simultaneously occurring independent phenomena with a common origin.« less

Presurgical language fMRI: Mapping of six critical regions

PubMed Central

Walshaw, Patricia D.; Hale, Kayleigh; Gaillard, William D.; Baxter, Leslie C.; Berl, Madison M.; Polczynska, Monika; Noble, Stephanie; Alkawadri, Rafeed; Hirsch, Lawrence J.; Constable, R. Todd; Bookheimer, Susan Y.

2017-01-01

Abstract Language mapping is a key goal in neurosurgical planning. fMRI mapping typically proceeds with a focus on Broca's and Wernicke's areas, although multiple other language‐critical areas are now well‐known. We evaluated whether clinicians could use a novel approach, including clinician‐driven individualized thresholding, to reliably identify six language regions, including Broca's Area, Wernicke's Area (inferior, superior), Exner's Area, Supplementary Speech Area, Angular Gyrus, and Basal Temporal Language Area. We studied 22 epilepsy and tumor patients who received Wada and fMRI (age 36.4[12.5]; Wada language left/right/mixed in 18/3/1). fMRI tasks (two × three tasks) were analyzed by two clinical neuropsychologists who flexibly thresholded and combined these to identify the six regions. The resulting maps were compared to fixed threshold maps. Clinicians generated maps that overlapped significantly, and were highly consistent, when at least one task came from the same set. Cases diverged when clinicians prioritized different language regions or addressed noise differently. Language laterality closely mirrored Wada data (85% accuracy). Activation consistent with all six language regions was consistently identified. In blind review, three external, independent clinicians rated the individualized fMRI language maps as superior to fixed threshold maps; identified the majority of regions significantly more frequently; and judged language laterality to mirror Wada lateralization more often. These data provide initial validation of a novel, clinician‐based approach to localizing language cortex. They also demonstrate clinical fMRI is superior when analyzed by an experienced clinician and that when fMRI data is of low quality judgments of laterality are unreliable and should be withheld. Hum Brain Mapp 38:4239–4255, 2017. © 2017 Wiley Periodicals, Inc. PMID:28544168

Magnetospheric convection and the high-latitude F2 ionosphere

NASA Technical Reports Server (NTRS)

Knudsen, W. C.

1974-01-01

Behavior of the polar ionospheric F layer as it is convected through the cleft, over the polar cap, and through the nightside F layer trough zone is investigated. Passage through the cleft adds approximately 200,000 ions per cu cm in the vicinity of the F2 peak and redistributes the ionization above approximately 400-km altitude to conform with an increased electron temperature. The redistribution of ionization above 400-km altitude forms the 'averaged' plasma ring seen at 1000-km altitude. The F layer is also raised by approximately 20 km in altitude by the convection electric field. The time required for passage across the polar cap (25 deg) is about the same as that required for the F layer peak concentration to decay by e. The F layer response to passage through the nightside soft electron precipitation zone should be similar to but less than its response to passage through the cleft.

Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.

PubMed

Belsky, Justin B; Morris, Daniel C; Bouchebl, Ralph; Filbin, Michael R; Bobbitt, Kevin R; Jaehne, Anja K; Rivers, Emanuel P

2016-01-01

To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls. F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay's lowest detection range (78 ng/ml). F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock.

Analytical variables affecting analysis of F2-isoprostanes and F4-neuroprostanes in human cerebrospinal fluid by gas chromatography/mass spectrometry.

PubMed

Yen, Hsiu-Chuan; Wei, Hsing-Ju; Chen, Ting-Wei

2013-01-01

F2-isoprostanes (F2-IsoPs) are a gold marker of lipid peroxidation in vivo, whereas F4-neuroprostanes (F4-NPs) measured in cerebrospinal fluid (CSF) or brain tissue selectively indicate neuronal oxidative damage. Gas chromatography/negative-ion chemical-ionization mass spectrometry (GC/NICI-MS) is the most sensitive and robust method for quantifying these compounds, which is essential for CSF samples because abundance of these compounds in CSF is very low. The present study revealed potential interferences on the analysis of F2-IsoPs and F4-NPs in CSF by GC/NICI-MS due to the use of improper analytical methods that have been employed in the literature. First, simultaneous quantification of F2-IsoPs and F4-NPs in CSF samples processed for F4-NPs analysis could cause poor chromatographic separation and falsely higher F2-IsoPs values for CSF samples with high levels of F2-IsoPs and F4-NPs. Second, retention of unknown substances in GC columns from CSF samples during F4-NPs analysis and from plasma samples during F2-IsoPs analysis might interfere with F4-NPs analysis of subsequent runs, which could be solved by holding columns at a high temperature for a period of time after data acquisition. Therefore, these special issues should be taken into consideration when performing analysis of F2-IsoPs and F4-NPs in CSF to avoid misleading results.

Analytical Variables Affecting Analysis of F2-Isoprostanes and F4-Neuroprostanes in Human Cerebrospinal Fluid by Gas Chromatography/Mass Spectrometry

PubMed Central

Yen, Hsiu-Chuan; Wei, Hsing-Ju; Chen, Ting-Wei

2013-01-01

F2-isoprostanes (F2-IsoPs) are a gold marker of lipid peroxidation in vivo, whereas F4-neuroprostanes (F4-NPs) measured in cerebrospinal fluid (CSF) or brain tissue selectively indicate neuronal oxidative damage. Gas chromatography/negative-ion chemical-ionization mass spectrometry (GC/NICI-MS) is the most sensitive and robust method for quantifying these compounds, which is essential for CSF samples because abundance of these compounds in CSF is very low. The present study revealed potential interferences on the analysis of F2-IsoPs and F4-NPs in CSF by GC/NICI-MS due to the use of improper analytical methods that have been employed in the literature. First, simultaneous quantification of F2-IsoPs and F4-NPs in CSF samples processed for F4-NPs analysis could cause poor chromatographic separation and falsely higher F2-IsoPs values for CSF samples with high levels of F2-IsoPs and F4-NPs. Second, retention of unknown substances in GC columns from CSF samples during F4-NPs analysis and from plasma samples during F2-IsoPs analysis might interfere with F4-NPs analysis of subsequent runs, which could be solved by holding columns at a high temperature for a period of time after data acquisition. Therefore, these special issues should be taken into consideration when performing analysis of F2-IsoPs and F4-NPs in CSF to avoid misleading results. PMID:23957004

Geomagnetic conjugate observations of plasma bubbles and thermospheric neutral winds at equatorial latitudes

NASA Astrophysics Data System (ADS)

Fukushima, D.; Shiokawa, K.; Otsuka, Y.; Nishioka, M.; Kubota, M.; Tsugawa, T.; Nagatsuma, T.

2012-12-01

Plasma bubbles are plasma-density depletion which is developed by the Rayleigh-Taylor instability on the sunset terminator at equatorial latitudes. They usually propagate eastward after the sunset. The eastward propagation of the plasma bubbles is considered to be controlled by background eastward neutral winds in the thermosphere through the F-region dynamo effect. However, it is not clear how the F-region dynamo effect contributes to the propagation of the plasma bubbles, because plasma bubbles and background neutral winds have not been simultaneously observed at geomagnetic conjugate points in the northern and southern hemispheres. In this study, geomagnetic conjugate observations of the plasma bubbles at low latitudes with thermospheric neutral winds were reported. The plasma bubbles were observed at Kototabang (0.2S, 100.3E, geomagnetic latitude (MLAT): 10.0S), Indonesia and at Chiang Mai (18.8N, 98.9E, MLAT: 8.9N), Thailand, which are geomagnetic conjugate stations, on 5 April, 2011 from 13 to 22 UT (from 20 to 05 LT). These plasma bubbles were observed in the 630-nm airglow images taken by using highly-sensitive all-sky airglow imagers at both stations. They propagated eastward with horizontal velocities of about 100-125 m/s. Background thermospheric neutral winds were also observed at both stations by using two Fabry-Perot interferometers (FPIs). The eastward wind velocities were about 70-130 m/s at Kototabang, and about 50-90 m/s at Chiang Mai. We estimated ion drift velocities by using these neutral winds observed by FPIs and conductivities calculated from the IRI and MSIS models. The estimated velocities were about 60-90 % of the drift velocities of plasma bubbles. This result shows that most of the plasma bubble drift can be explained by the F-region dynamo effect, and additional electric field effect may come in to play.

a Case Study of Plasma Blob Associated with Plasma Bubble in Low Latitude Region in the Brazilian Sector Using All-Sky Images and DMSP Satellite

NASA Astrophysics Data System (ADS)

Tardelli, F. C.; Abalde, J. R.; Pimenta, A. A.; Kavutarapu, V.; Tardelli, A.

2016-12-01

Using optical techniques and satellite data a plasma blob case was observed on February 23, 2007, in São José dos Campos (SJC) (23.21°S, 45.86°O; dip. Lat. 17.6°S) in the Brazilian sector. This is the first observation of plasma blob in SJC region using data from optical techniques and satellite measurements. The plasma blob is the enhancements in plasma density by a factor of 2 or more above background plasma. Simultaneous all-sky images were used to map the spatial extent of plasma blob. DMSP satellite data were used to confirm the enhancements in plasma density in the ionosphere, which provides important parameters of the ionospheric behavior during the event. During the night of present study, the plasma blob was associated with a plasma bubble and the average zonal drift velocities are 61±6 m-s and 74±8 m-s, respectively. The average North/South and East/West extension of the blob were 591 km and 328 km, respectively. Furthermore, the average longitudinal drift velocity was 85±13 m-s. In this work plasma density is found to be enhanced by a factor of 2 compared to the background plasma. We report for the first time plasma blob in SJC at low latitude region associated with plasma bubble and present important features of their behavior.

Syntheses, Raman spectra, and X-ray crystal structures of [XeF(5)][mu-F(OsO(3)F(2))(2)] and [M][OsO(3)F(3)] (M = XeF(5)(+), Xe(2)F(11)(+)).

PubMed

Hughes, Michael J; Mercier, Hélène P A; Schrobilgen, Gary J

2010-04-05

Stoichiometric amounts of XeF(6) and (OsO(3)F(2))(infinity) react at 25-50 degrees C to form salts of the known XeF(5)(+) and Xe(2)F(11)(+) cations, namely, [XeF(5)][mu-F(OsO(3)F(2))(2)], [XeF(5)][OsO(3)F(3)], and [Xe(2)F(11)][OsO(3)F(3)]. Although XeF(6) is oxophilic toward a number of transition metal and main-group oxides and oxide fluorides, fluoride/oxide metathesis was not observed. The series provides the first examples of noble-gas cations that are stabilized by metal oxide fluoride anions and the first example of a mu-F(OsO(3)F(2))(2)(-) salt. Both [XeF(5)][mu-F(OsO(3)F(2))(2)] and [Xe(2)F(11)][OsO(3)F(3)] are orange solids at room temperature. The [XeF(5)][OsO(3)F(3)] salt is an orange liquid at room temperature that solidifies at 5-0 degrees C. When the salts are heated at 50 degrees C under 1 atm of N(2) for more than 2 h, significant XeF(6) loss occurs. The X-ray crystal structures (-173 degrees C) show that the salts exist as discrete ion pairs and that the osmium coordination spheres in OsO(3)F(3)(-) and mu-F(OsO(3)F(2))(2)(-) are pseudo-octahedral OsO(3)F(3)-units having facial arrangements of oxygen and fluorine atoms. The mu-F(OsO(3)F(2))(2)(-) anion is comprised of two symmetry-related OsO(3)F(2)-groups that are fluorine-bridged to one another. Ion pairing results from secondary bonding interactions between the fluorine/oxygen atoms of the anions and the xenon atom of the cation, with the Xe...F/O contacts occurring opposite the axial fluorine and from beneath the equatorial XeF(4)-planes of the XeF(5)(+) and Xe(2)F(11)(+) cations so as to avoid the free valence electron lone pairs of the xenon atoms. The xenon atoms of [XeF(5)][mu-F(OsO(3)F(2))(2)] and [Xe(2)F(11)][OsO(3)F(3)] are nine-coordinate and the xenon atom of [XeF(5)][OsO(3)F(3)] is eight-coordinate. Quantum-chemical calculations at SVWN and B3LYP levels of theory were used to obtain the gas-phase geometries, vibrational frequencies, and NBO bond orders, valencies, and NPA charges of

Possible antigravity regions in F(R) theory?

NASA Astrophysics Data System (ADS)

Bamba, Kazuharu; Nojiri, Shin'ichi; Odintsov, Sergei D.; Sáez-Gómez, Diego

2014-03-01

We construct an F(R) gravity theory corresponding to the Weyl invariant two scalar field theory. We investigate whether such F(R) gravity can have the antigravity regions where the Weyl curvature invariant does not diverge at the Big Bang and Big Crunch singularities. It is revealed that the divergence cannot be evaded completely but can be much milder than that in the original Weyl invariant two scalar field theory.

Equilibrium modeling of 5-HT(2A) receptors with [18F]deuteroaltanserin and PET: feasibility of a constant infusion paradigm.

PubMed

van Dyck, C H; Soares, J C; Tan, P Z; Staley, J K; Baldwin, R M; Amici, L A; Fu, X; Garg, P K; Seibyl, J P; Charney, D S; Innis, R B

2000-11-01

[(18)F]Altanserin has emerged as a promising positron emission tomography (PET) ligand for serotonin-2A (5-HT(2A)) receptors. The deuterium substitution of both of the 2'-hydrogens of altanserin ([(18)F]deuteroaltanserin) yields a metabolically more stable radiotracer with higher ratios of parent tracer to radiometabolites and increased specific brain uptake than [(18)F]altanserin. The slower metabolism of the deuterated analog might preclude the possibility of achieving stable plasma and brain activities with a bolus plus constant infusion within a reasonable time frame for an (18)F-labeled tracer (T(1/2) 110 min). Thus, the purpose of this study was to test the feasibility in human subjects of a constant infusion paradigm for equilibrium modeling of [(18)F]deuteroaltanserin with PET. Seven healthy male subjects were injected with [(18)F]deuteroaltanserin as a bolus plus constant infusion lasting 10 h postinjection. PET acquisitions and venous blood sampling were performed throughout the infusion period. Linear regression analysis revealed that time-activity curves for both specific brain uptake and plasma [(18)F]deuteroaltanserin concentration stabilized after about 5 h. This permitted equilibrium modeling and estimation of V(')(3) (ratio of specific uptake to total plasma parent concentration) and the binding potential V(3) (ratio of specific uptake to free plasma parent concentration). Cortical/cerebellar ratios were increased by 26% relative to those we previously observed with [(18)F]altanserin using similar methodology in a somewhat older subject sample. These results demonstrate feasibility of equilibrium imaging with [(18)F]deuteroaltanserin and suggest that it may be superior to [(18)F]altanserin as a PET radioligand.

Electron impact elastic and excitation cross-sections of the isomers of C4F6 molecule for plasma modeling

NASA Astrophysics Data System (ADS)

Gupta, Dhanoj; Song, Mi-Young; Baluja, K. L.; Choi, Heechol; Yoon, Jung-Sik

2018-06-01

We report the calculations of elastic (along with its symmetry components) and electronic excitation cross sections by electron impact of the three isomers of C4F6, namely, hexafluoro-1,3-butadiene (1,3-C4F6), hexafluoro-2-butyne (2-C4F6), and hexafluorocyclobutene (c-C4F6) belonging to the point groups C2, D3d, and C2v, respectively, using the R-matrix approach. The electron energy range is from 0.01 eV to 12 eV. We have employed the cc-pVTZ basis set for C and F atoms to generate self-consistent field molecular orbitals to construct the target states for all the isomers included in our calculations. All the target states are constructed by including correlation effects in a configuration interaction (CI) approach. The target properties such as vertical excitation energies and dipole moment of all the isomers are in reasonable agreement with the literature values. Differences in the cross sections of these isomers are strongly influenced by the effect of correlation and polarization effects and their geometrical extent. We have included the ground state and many excited states of each isomer in the trial wave function of the entire scattering system. The resulting elastic cross sections are compared with the available experimental results. The agreement is reasonably good for energies above 5 eV. The shape resonances detected at 2.57, 2.95, and 3.20 eV for c-C4F6, 1,3-C4F6, and 2-C4F6 isomers are associated with the negative anion formation of C3F3- as observed in the mass spectrometry experiments. We have also performed 1-state CI calculation for all the isomers that include only the correlated ground state. The position of resonances shifts to lower energies as the number of target states is increased compared to 1-state calculation for all the isomers. The elastic cross section for 2-C4F6 isomer is larger than the other isomers because of its larger spatial extent. The present cross section data are important for plasma simulation and modeling, especially

Cloning and characterization of two duplicated interleukin-17A/F2 genes in common carp (Cyprinus carpio L.): Transcripts expression and bioactivity of recombinant IL-17A/F2.

PubMed

Li, Hongxia; Yu, Juhua; Li, Jianlin; Tang, Yongkai; Yu, Fan; Zhou, Jie; Yu, Wenjuan

2016-04-01

Interleukin-17 (IL-17) plays an important role in inflammation and host defense in mammals. In this study, we identified two duplicated IL-17A/F2 genes in the common carp (Cyprinus carpio) (ccIL-17A/F2a and ccIL-17A/F2b), putative encoded proteins contain 140 amino acids (aa) with conserved IL-17 family motifs. Expression analysis revealed high constitutive expression of ccIL-17A/F2s in mucosal tissues, including gill, skin and intestine, their expression could be induced by Aeromonas hydrophila, suggesting a potential role in mucosal immunity. Recombinant ccIL-17A/F2a protein (rccIL-17A/F2a) produced in Escherichia coli could induce the expression of proinflammatory cytokines (IL-1β) and the antimicrobial peptides S100A1, S100A10a and S100A10b in the primary kidney in a dose- and time-dependent manner. Above findings suggest that ccIL-17A/F2 plays an important role in both proinflammatory and innate immunity. Two duplicated ccIL-17A/F2s showed different expression level with ccIL-17A/F2a higher than b, comparison of two 5' regulatory regions indicated the length from anticipated promoter to transcriptional start site (TSS) and putative transcription factor binding site (TFBS) were different. Promoter activity of ccIL-17A/F2a was 2.5 times of ccIL-17A/F2b which consistent with expression results of two genes. These suggest mutations in 5'regulatory region contributed to the differentiation of duplicated genes. To our knowledge, this is the first report to analyze 5'regulatory region of piscine IL-17 family genes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study.

PubMed

Sorger, Dietlind; Becker, Georg A; Patt, Marianne; Schildan, Andreas; Grossmann, Udo; Schliebs, Reinhard; Seese, Anita; Kendziorra, Kai; Kluge, Magnus; Brust, Peter; Mukhin, Alexey G; Sabri, Osama

2007-04-01

2-[(18)F]fluoro-A-85380 (2-[(18)F]FA) is a new radioligand for noninvasive imaging of alpha4beta2* nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET) in human brain. In most cases, quantification of 2-[(18)F]FA receptor binding involves measurement of free nonmetabolized radioligand concentration in blood. This requires an efficient and reliable method to separate radioactive metabolites from the parent compound. In the present study, three analytical methods, thin layer chromatography (TLC), high-performance liquid chromatography (HPLC) and solid phase extraction (SPE) have been tested. Reversed-phase TLC of deproteinized aqueous samples of plasma provides good estimates of 2-[(18)F]FA and its metabolites. However, because of the decreased radioactivity in plasma samples, this method can be used in humans over the first 2 h after radioligand injection only. Reliable quantification of the parent radioligand and its main metabolites was obtained using reversed-phase HPLC, followed by counting of eluted fractions in a well gamma counter. Three main and five minor metabolites of 2-[(18)F]FA were detected in human blood using this method. On average, the unchanged 2-[(18)F]FA fraction in plasma of healthy volunteers measured at 14, 60, 120, 240 and 420 min after radioligand injection was 87.3+/-2.2%, 74.4+/-3%, 68.8+/-5%, 62.3+/-8% and 61.0+/-8%, respectively. In patients with neurodegenerative disorders, the values corresponding to the three last time points were significantly lower. The fraction of nonmetabolized 2-[(18)F]FA in plasma determined using SPE did not differ significantly from that obtained by HPLC (+gamma counting) (n=73, r=.95). Since SPE is less time-consuming than HPLC and provides comparable results, we conclude that SPE appears to be the most suitable method for measurement of 2-[(18)F]FA parent fraction during PET investigations.

Guest investigator program study: Physics of equatorial plasma bubbles

NASA Technical Reports Server (NTRS)

Tsunoda, Roland T.

1994-01-01

Plasma bubbles are large-scale (10 to 100 km) depletions in plasma density found in the night-time equatorial ionosphere. Their formation has been found to entail the upward transport of plasma over hundreds of kilometers in altitude, suggesting that bubbles play significant roles in the physics of many of the diverse and unique features found in the low-latitude ionosphere. In the simplest scenario, plasma bubbles appear first as perturbations in the bottomside F layer, which is linearly unstable to the gravitationally driven Rayleigh-Taylor instability. Once initiated, bubbles develop upward through the peak of the F layer into its topside (sometimes to altitudes in excess of 1000 km), a behavior predicted by the nonlinear form of the same instability. While good general agreement has been found between theory and observations, little is known about the detailed physics associated with plasma bubbles. Our research activity centered around two topics: the shape of plasma bubbles and associated electric fields, and the day-to-day variability in the occurrence of plasma bubbles. The first topic was pursued because of a divergence in view regarding the nonlinear physics associated with plasma bubble development. While the development of perturbations in isodensity contours in the bottomside F layer into plasma bubbles is well accepted, some believed bubbles to be cylinder-like closed regions of depleted plasma density that floated upward leaving a turbulent wake behind them (e.g., Woodman and LaHoz, 1976; Ott, 1978; Kelley and Ott, 1978). Our results, summarized in a paper submitted to the Journal of Geophysical Research, consisted of incoherent scatter radar measurements that showed unambiguously that the depleted region is wedgelike and not cylinderlike, and a case study and modeling of SM-D electric field instrument (EFI) measurements that showed that the absence of electric-field perturbations outside the plasma-depleted region is a distinct signature of wedge

The variable rotation period of the inner region of Saturn's plasma disk.

PubMed

Gurnett, D A; Persoon, A M; Kurth, W S; Groene, J B; Averkamp, T F; Dougherty, M K; Southwood, D J

2007-04-20

We show that the plasma and magnetic fields in the inner region of Saturn's plasma disk rotate in synchronism with the time-variable modulation period of Saturn's kilometric radio emission. This relation suggests that the radio modulation has its origins in the inner region of the plasma disk, most likely from a centrifugally driven convective instability and an associated plasma outflow that slowly slips in phase relative to Saturn's internal rotation. The slippage rate is determined by the electrodynamic coupling of the plasma disk to Saturn and by the drag force exerted by its interaction with the Enceladus neutral gas torus.

Comparison of ionospheric F2 peak parameters foF2 and hmF2 with IRI2001 at Hainan

NASA Astrophysics Data System (ADS)

Wang, X.; Shi, J. K.; Wang, G. J.; Gong, Y.

2009-06-01

Monthly median values of foF2, hmF2 and M(3000)F2 parameters, with quarter-hourly time interval resolution for the diurnal variation, obtained with DPS4 digisonde at Hainan (19.5°N, 109.1°E; Geomagnetic coordinates: 178.95°E, 8.1°N) are used to investigate the low-latitude ionospheric variations and comparisons with the International Reference Ionosphere (IRI) model predictions. The data used for the present study covers the period from February 2002 to April 2007, which is characterized by a wide range of solar activity, ranging from high solar activity (2002) to low solar activity (2007). The results show that (1) Generally, IRI predictions follow well the diurnal and seasonal variation patterns of the experimental values of foF2, especially in the summer of 2002. However, there are systematic deviation between experimental values and IRI predictions with either CCIR or URSI coefficients. Generally IRI model greatly underestimate the values of foF2 from about noon to sunrise of next day, especially in the afternoon, and slightly overestimate them from sunrise to about noon. It seems that there are bigger deviations between IRI Model predictions and the experimental observations for the moderate solar activity. (2) Generally the IRI-predicted hmF2 values using CCIR M(3000)F2 option shows a poor agreement with the experimental results, but there is a relatively good agreement in summer at low solar activity. The deviation between the IRI-predicted hmF2 using CCIR M(3000)F2 and observed hmF2 is bigger from noon to sunset and around sunrise especially at high solar activity. The occurrence time of hmF2 peak (about 1200 LT) of the IRI model predictions is earlier than that of observations (around 1500 LT). The agreement between the IRI hmF2 obtained with the measured M(3000)F2 and the observed hmF2 is very good except that IRI overestimates slightly hmF2 in the daytime in summer at high solar activity and underestimates it in the nighttime with lower values near

Plasma waves near the magnetopause

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, R.R.; Haravey, C.C.; Hoppe, M.M.

1982-04-01

Plasma waves associated with the magnetopause, from the magnetosheath to the outer magnetosphere, are examined with an emphasis on high time resolution data and the comparison between measurements by using different antenna systems. An early ISEE crossing of the magnetopause region, including passage through two well-defined flux transfer events, the magentopause current layer, and boundary plasma, is studied in detail. The waves in these regions are compared and contrasted with the waves in the adjoining magnetosheath and outer magnetosphere. Four types of plamsa wave emissions are characteristic of the nominal magnetosheat: (1) a very low frequency continuum, (2) short wavelengthmore » spikes, (3) 'festoon-shaped' emissions below about 2 kHz, and (4) 'lion roars'. The latter two emissions are well correlated with ultra-low frequency magnetic field fluctuations. The dominant plasma wave features during flux transfer events are (1) an intense low-frequency continuum, which includes a substantial electromagnetic component, (2) a dramatic increase in the frequency of occurrence of the spikes, (3) quasi-periodic electron cyclotron harmonics correlated with approx.1-Hz magnetic field fluctuations, and (4) enhanced electron plasma oscillations. The plasma wave characteristics in the current layer and in the boundary layer are quite similar to the features in the flux transfer events. Upon entry into the outer magnetosphere, the plasma wave spectra are dominated by intense electromagnetic chorus bursts and electrosatic (n+1/2)f/sup -//sub g/ emissions. Wavelength determinations made by comparing the various antenna responses and polarization measurements for the different waves are also presented.« less

Plasma electron analysis: Voyager plasma science experiment

NASA Technical Reports Server (NTRS)

Sittler, E. C., Jr.

1983-01-01

The Plasma Science Experiment (PLS) on the Voyager spacecraft provide data on the plasma ions and electrons in the interplanetary medium and the magnetospheres of the giant planets Jupiter and Saturn. A description of the analysis used to obtain electron parameters (density, temperature, etc.) from the plasma science experiment PLS electron measurements which cover the energy range from 10 eV to 5950 eV is presented. The electron sensor (D cup) and its transmission characteristics are described. A derivation of the fundamental analytical expression of the reduced distribution function F(e) is given. The electron distribution function F(e), used in the moment integrations, can be derived from F(e). Positive ions produce a correction current (ion feedthrough) to the measured electron current, which can be important to the measurements of the suprathermal electron component. In the case of Saturn, this correction current, which can either add to or subtract from the measured electron current, is less than 20% of the measured signal at all times. Comments about the corrections introduced by spacecraft charging to the Saturn encounter data, which can be important in regions of high density and shadow when the spacecraft can become negatively charged are introduced.

Relationship between ionospheric F2-layer critical frequency, F10.7, and F10.7P around African EIA trough

NASA Astrophysics Data System (ADS)

Ikubanni, S. O.; Adeniyi, J. O.

2017-02-01

Improved ionospheric modeling requires a better understanding of the relationship between ionospheric parameters and their influencing solar and geomagnetic sources. Published reports of the validation of the International Reference Ionosphere (IRI) for quiet-time revealed either underestimation or overestimation at a greater magnitude during high solar fluxes, especially at low latitude. With daily foF2 data from Ouagadougou (geor. 12.4°N, 1.5°W) covering a solar cycle, we have presented preliminary results from the analysis of solar dependence of six different classifications of the data: (i) daily values, (ii) monthly mean, (iii) daily quiet values (with Ap ⩽ 20), (iv) monthly-quiet-mean values, (v) monthly median, and (vi) monthly-quiet-median values. All six classifications show good nonlinear relationship with both F10.7 and F10.7P, however, the differences between the dependence of classes (i) and (iii) of foF2 on the two solar indices is more substantial than those of classes (ii), (iv), (v), and (vi). Of all the six classes, the monthly averages are best related to both solar activity indices. Further analysis shows that magnetic disturbances are non-influential in the variations of the monthly mean of both solar activity indices; this makes both good indices for quiet-time modeling. Likewise, F10.7 and F10.7P are indistinguishable for long-term modeling around the African EIA trough region. While monthly median values may be best for mid-latitude region, either the mean/median values could be used for low-latitude region. However, it could be worthwhile to examine the distribution of the data from the station under consideration.

Dietary fats and F2-isoprostanes: A review of the clinical evidence.

PubMed

Da Silva, Marine S; Bilodeau, Jean-François; Julien, Pierre; Rudkowska, Iwona

2017-12-12

Evidence supports that a high dietary fat intake increases oxidative stress and the risk of diet-induced metabolic disorders such as obesity, diabetes and cardiovascular diseases. F 2 -isoprostanes (F 2 -isoP) are formed by the non-enzymatic oxidation of arachidonic acid and are widely used as reliable biomarkers of oxidative stress in clinical studies. Dietary fats may influence F 2 -isoP levels, as they (1) are metabolic substrates for their formation, (2) modify the lipid composition of tissues, and (3) affect the plasma lipoprotein concentrations which are involved in F 2 -isoP transport. This review examined the latest clinical evidence on how dietary fats can affect blood circulation and excretion of F 2 -isoP in individuals with healthy or deteriorated metabolic profiles. Clinical studies reported that saturated or monounsaturated fat-rich diets did not affect F 2 -isoP levels in adults with healthy or deteriorated metabolic profiles. Though, ω-3 polyunsaturated fatty acids decreased F 2 -isoP levels in numerous studies, whereas trans-fatty acids raised F 2 -isoP excretion. Yet, the reported heterogeneous results reveal important considerations, such as the health status of the participants, the biological fluids used to determine F 2 -isoP, the analytical methods employed and the specific F 2 -isoP isomers detected. Therefore, future clinical studies should be designed in order to consider these issues in the studies of the effects of fat intake on oxidative stress.

Oxidation of laser-induced plasma species in different background conditions

NASA Astrophysics Data System (ADS)

Bator, Matthias; Schneider, Christof W.; Lippert, Thomas; Wokaun, Alexander

2013-08-01

The evolution of Lu and LuO species in a laser ablation plasma from different targets has been investigated by simultaneously performing mass spectrometry and plasma imaging. Ablation was achieved with a 248 nm KrF laser from a Lu, a Lu2O5 and a LuMnO3 target under different background gas conditions. Mass spectrometry measurements show very similar intensities and ratios for the respective species for all three targets under the same ablation conditions. This indicates only a small influence of the target on the final Lu and LuO contents in the plasma, with the major influence coming from collisions with the background gas. Furthermore, spatially, timely and spectrally resolved plasma imaging was utilized to clearly identify the shockwave at the plasma front as the main region for Lu oxidation. A strong decrease of Lu intensities together with a directly correlated increase of LuO was observed toward the outer regions of the plasma.

A Monte Carlo Sensitivity Analysis of CF2 and CF Radical Densities in a c-C4F8 Plasma

NASA Technical Reports Server (NTRS)

Bose, Deepak; Rauf, Shahid; Hash, D. B.; Govindan, T. R.; Meyyappan, M.

2004-01-01

A Monte Carlo sensitivity analysis is used to build a plasma chemistry model for octacyclofluorobutane (c-C4F8) which is commonly used in dielectric etch. Experimental data are used both quantitatively and quantitatively to analyze the gas phase and gas surface reactions for neutral radical chemistry. The sensitivity data of the resulting model identifies a few critical gas phase and surface aided reactions that account for most of the uncertainty in the CF2 and CF radical densities. Electron impact dissociation of small radicals (CF2 and CF) and their surface recombination reactions are found to be the rate-limiting steps in the neutral radical chemistry. The relative rates for these electron impact dissociation and surface recombination reactions are also suggested. The resulting mechanism is able to explain the measurements of CF2 and CF densities available in the literature and also their hollow spatial density profiles.

In vivo assessment and dosimetry of 2 novel PDE10A PET radiotracers in humans: 18F-MNI-659 and 18F-MNI-654.

PubMed

Barret, Olivier; Thomae, David; Tavares, Adriana; Alagille, David; Papin, Caroline; Waterhouse, Rikki; McCarthy, Timothy; Jennings, Danna; Marek, Ken; Russell, David; Seibyl, John; Tamagnan, Gilles

2014-08-01

Phosphodiesterase (PDE) 10A is an enzyme involved in the regulation of cyclic adenosine monophosphate and cyclic guanosine monophosphate and is highly expressed in medium-sized spiny neurons of the striatum, making it an attractive target for novel therapies for a variety of neurologic and psychiatric disorders that involve striatal function. Potential ligands for PET imaging of PDE10A have been reported. Here, we report the first-in-human characterization of 2 new PDE10A radioligands, 2-(2-(3-(1-(2-fluoroethyl)-1H-indazol-6-yl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ((18)F-MNI-654) and 2-(2-(3-(4-(2-fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ((18)F-MNI-659), with the goal of selecting the best one for use in future studies interrogating pathophysiologic changes in neuropsychiatric disorders and aiding pharmaceutical development targeting PDE10A. Eleven healthy volunteers participated in this study ((18)F-MNI-654 test-retest, 2 men; (18)F-MNI-659 test-retest, 4 men and 1 woman; (18)F-MNI-659 dosimetry, 2 men and 2 women). Brain PET images were acquired over 5.5 h for (18)F-MNI-654 and over 3.5 h for (18)F-MNI-659, and pharmacokinetic modeling with plasma- and reference-region (cerebellar cortex)-based methods was performed. Whole-body PET images were acquired over 6 h for (18)F-MNI-659 and radiation dosimetry estimated with OLINDA. Both radiotracers were similarly metabolized, with about 20% of intact parent remaining at 120 min after injection. PET time-activity data demonstrated that (18)F-MNI-654 kinetics were much slower than (18)F-MNI-659 kinetics. For (18)F-MNI-659, there was good agreement between the Logan and simplified reference tissue models for nondisplaceable binding potential (BPND), supporting noninvasive quantification, with test-retest variability less than 10% and intraclass correlation greater than 0.9. The (18)F-MNI-659 effective dose was

Twinned or not twinned, that is the question: crystallization and preliminary crystallographic analysis of the 2F1(3)F1 module pair of human fibronectin.

PubMed

Rudiño-Piñera, Enrique; Schwarz-Linek, Ulrich; Potts, Jennifer R; Garman, Elspeth F

2004-07-01

Human fibronectin (Fn) is a large multidomain protein found in the extracellular matrix and plasma. It is involved in many cellular processes, including cell adhesion and migration during embryogenesis and wound healing. The ability to bind Fn is a characteristic that has been demonstrated for a number of pathogens. For Staphylococcus aureus and Streptococcus pyogenes in particular, Fn-binding bacterial proteins (FnBPs) have been shown to mediate not only bacterial adhesion to host cells but also the uptake of bacteria by the cells. FnBPs interact with the amino-terminal region of Fn, where five type I ((1-5)F1) Fn modules are located. Although the structures of two F1 module pairs have been determined by NMR, no X-ray structures have been reported. To explore the conformational interactions between modules and the binding properties of FnBPs, the (2)F1(3)F1 module pair was crystallized using the vapour-diffusion method at 298 K. 12 X-ray diffraction data sets have been collected: six on an in-house rotating anode (three native, one Pt derivative and two peptide-bound) and six at synchrotron-radiation sources (two native and four derivative). Following analysis of these data, some of which have very high multiplicity (up to 50), probable space-group assignments were made (P42(1)2, P4(1)2(1)2 or P4(3)2(1)2) and the possibly twinned nature of the crystals was investigated using six different tests. The results presented here suggest that the crystals are not twinned.

Synthesis and X-ray crystal structure of (OsO(3)F(2))(2)2XeOF(4) and the Raman spectra of (OsO(3)F(2))(infinity), (OsO(3)F(2))(2), and (OsO(3)F(2))(2)2XeOF(4).

PubMed

Hughes, Michael J; Mercier, Hélène P A; Schrobilgen, Gary J

2009-05-18

The adduct, (OsO(3)F(2))(2)2XeOF(4), was synthesized by dissolution of the infinite chain polymer, (OsO(3)F(2))(infinity), in XeOF(4) solvent at room temperature followed by removal of excess XeOF(4) under dynamic vacuum at 0 degrees C. Continued pumping at 0 degrees C resulted in removal of associated XeOF(4), yielding (OsO(3)F(2))(2), a new low-temperature phase of OsO(3)F(2). Upon standing at 25 degrees C for 1(1)/(2) h, (OsO(3)F(2))(2) underwent a phase transition to the known monoclinic phase, (OsO(3)F(2))(infinity). The title compounds, (OsO(3)F(2))(infinity), (OsO(3)F(2))(2), and (OsO(3)F(2))(2)2XeOF(4) have been characterized by low-temperature (-150 degrees C) Raman spectroscopy. Crystallization of (OsO(3)F(2))(2)2XeOF(4) from XeOF(4) solution at 0 degrees C yielded crystals suitable for X-ray structure determination. The structural unit contains the (OsO(3)F(2))(2) dimer in which the OsO(3)F(3) units are joined by two Os---F---Os bridges having fluorine bridge atoms that are equidistant from the osmium centers (2.117(5) and 2.107(4) A). The dimer coordinates to two XeOF(4) molecules through Os-F...Xe bridges in which the Xe...F distances (2.757(5) A) are significantly less than the sum of the Xe and F van der Waals radii (3.63 A). The (OsO(3)F(2))(2) dimer has C(i) symmetry in which each pseudo-octahedral OsO(3)F(3) unit has a facial arrangement of oxygen ligands with XeOF(4) molecules that are only slightly distorted from their gas-phase C(4v) symmetry. Quantum-chemical calculations using SVWN and B3LYP methods were employed to calculate the gas-phase geometries, natural bond orbital analyses, and vibrational frequencies of (OsO(3)F(2))(2), (OsO(3)F(2))(2)2XeOF(4), XeOF(4), OsO(2)F(4), and (mu-FOsO(3)F(2))(2)OsO(3)F(-) to aid in the assignment of the experimental vibrational frequencies of (OsO(3)F(2))(2), (OsO(3)F(2))(2)2XeOF(4), and (OsO(3)F(2))(infinity). The vibrational modes of the low-temperature polymeric phase, (OsO(3)F(2))(infinity), have been

Investigation of the relationship between ionospheric foF2 and earthquakes

NASA Astrophysics Data System (ADS)

Karaboga, Tuba; Canyilmaz, Murat; Ozcan, Osman

2018-04-01

Variations of the ionospheric F2 region critical frequency (foF2) have been investigated statistically before earthquakes during 1980-2008 periods in Japan area. Ionosonde data was taken from Kokubunji station which is in the earthquake preparation zone for all earthquakes. Standard Deviations and Inter-Quartile Range methods are applied to the foF2 data. It is observed that there are anomalous variations in foF2 before earthquakes. These variations can be regarded as ionospheric precursors and may be used for earthquake prediction.

Variational electric fields at low latitudes and their relation to spread F and plasma irregularities

NASA Technical Reports Server (NTRS)

Holtet, J. A.; Maynard, N. C.; Heppner, J. P.

1976-01-01

Recordings from OGO 6 show that electric field irregularities are frequently present between + or - 35 deg geomagnetic latitude in the 2000 - 0600 local time sector. The signatures are very clear, and are easily distinguished from the normal AC background noise, and whistler and emission activity. The spectral appearance of the fields makes it meaningful to distinguish between 3 different types of irregularities: strong irregularities, weak irregularities, and weak irregularities with a rising spectrum. Strong irregularities seem most likely to occur in regions where gradients in ionization are present. Changes in plasma composition, resulting in an increase in the mean ion mass, are also often observed in the irregularity regions. Comparison with ground based ionosondes indicates a connection between strong irregularities and low latitude spread F. A good correlation is also present between strong fields and small scale fluctuations in ionization, delta N/N 1 percent. From the data it appears as if a gradient driven instability is the most likely source of the strong irregularities.

Dusty plasma sheath-like structure in the lunar terminator region

NASA Astrophysics Data System (ADS)

Popel, Sergey; Zelenyi, Lev; Atamaniuk, Barbara

2016-07-01

The main properties of the dusty plasma layer near the surface over the illuminated and dark parts of the Moon are described. They are used to realize dusty plasma behaviour and to determine electric fields over the terminator region. Possibility of the existence of a dusty plasma sheath-like structure [1] in the region of lunar terminator is shown. The electric fields excited in the terminator region are demonstrated to be on the order of 300 V/m. These electric fields can result in rise of dust particles of the size of a few micrometers up to an altitude of about 30 cm over the lunar surface that explains the effect of ``horizon glow" observed at the terminator by Surveyor lunar lander. This work was supported in part by the Presidium of the Russian Academy of Sciences (under Fundamental Research Program No. 7, ``Experimental and Theoretical Study of the Solar System Objects and Stellar Planet Systems. Transient Explosion Processes in Astrophysics" and the Russian Foundation for Basic Research (Project No. 15-02-05627-a). [1] S. I. Popel, L. M. Zelenyi, and B. Atamaniuk, Phys. Plasmas 22, 123701 (2015); doi: 10.1063/1.4937368.

Pressure-induced photoluminescence in Mn2+-doped BaF2 and SrF2 fluorites

NASA Astrophysics Data System (ADS)

Hernández, Ignacio; Rodríguez, Fernando

2003-01-01

This work reports an effective way for inducing room temperature photoluminescence (PL) in Mn2+-doped BaF2 and SrF2 using high-pressure techniques. The aim is to understand the surprising PL behavior exhibited by Mn2+ at the cubal site of the fluorite structure. While Mn2+-doped CaF2 shows a green PL with quantum yield close to 1 at room temperature, Mn2+-doped MF2 (M=Ba,Sr) is not PL either at room temperature (SrF2) or at any temperature (BaF2) at ambient pressure. We associate the loss of Mn2+ PL on passing from CaF2 to SrF2 or BaF2 with nonradiative multiphonon relaxation whose thermal activation energy decreases along the series CaF2→SrF2→BaF2. A salient feature of this work deals with the increase of activation energy induced by pressure. It leads to a quantum yield enhancement, which favors PL recovery. Furthermore, the activation energy mainly depends on the crystal volume per molecule irrespective of the crystal structure or the local symmetry around the impurity. In this way, the relevance of the fluorite-to-cotunnite phase transition is analyzed in connection with the PL properties of the investigated compounds. The PL spectrum and the corresponding lifetime are reported for both structural phases as a function of pressure.

Reflection polarizers for the vacuum ultraviolet using Al + MgF2 mirrors and an MgF2 plate

NASA Technical Reports Server (NTRS)

Hass, G.; Hunter, W. R.

1978-01-01

Consideration is given to the design and operation of a three-mirror reflecting polarizer where one of the reflecting surfaces is an MgF2 plate, the other surfaces are Al + MgF2 coatings, and one reflection occurs at or near the true Brewster angle. It is found that the polarizer is most efficient in the 1200-2000 A wavelength region, and that by optimum selection of the angle of incidence on the MgF2 plate, polarization values of 100 and over are yielded from 900 to 3000 A. The polarizer may be used at wavelengths as short as 500 A, although it is observed that at such wavelengths the polarization value decreases to about 10. It is noted that all reflecting polarizers operating in the vacuum ultraviolet wavelength may manifest changing characteristics as their mirrors become contaminated, and that polarization must therefore be occasionally remeasured.

Parameters to Maximize 2f2-f1 Distortion Product Otoacoustic Emission Levels

ERIC Educational Resources Information Center

Horn, Jennifer H.; Pratt, Shiela R.; Durrant, John D.

2008-01-01

Purpose: Past research has established parameters for the 2f1-f2 distortion product otoacoustic emissions (DPOAEs) that enhance response levels (e.g., L1 - L2 = 10 dB; f2/f1 = 1.22; L1, L2 = 65, 55 dB SPL). These same parameters do not optimize 2f2-f1 DPOAEs. Therefore, this study was conducted to evaluate more completely those parameters that…

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

PubMed Central

Bandara, L R; Buck, V M; Zamanian, M; Johnston, L H; La Thangue, N B

1993-01-01

It is widely believed that the cellular transcription factor DRTF1/E2F integrates cell cycle events with the transcription apparatus because during cell cycle progression in mammalian cells it interacts with molecules that are important regulators of cellular proliferation, such as the retinoblastoma tumour suppressor gene product (pRb), p107, cyclins and cyclin-dependent kinases. Thus, pRb, which negatively regulates early cell cycle progression and is frequently mutated in tumour cells, and the Rb-related protein p107, bind to and repress the transcriptional activity of DRTF1/E2F. Viral oncoproteins, such as adenovirus E1a and SV40 large T antigen, overcome such repression by sequestering pRb and p107 and in so doing are likely to activate genes regulated by DRTF1/E2F, such as cdc2, c-myc and DHFR. Two sequence-specific DNA binding proteins, E2F-1 and DP-1, which bind to the E2F site, contain a small region of similarity. The functional relationship between them has, however, been unclear. We report here that DP-1 and E2F-1 exist in a DNA binding complex in vivo and that they bind efficiently and preferentially as a heterodimer to the E2F site. Moreover, studies in yeast and Drosophila cells indicate that DP-1 and E2F-1 interact synergistically in E2F site-dependent transcriptional activation. Images PMID:8223441

Latitudinal Variations Of The F3 Layer Observed From The SEALION Ionosonde Network

NASA Astrophysics Data System (ADS)

Uemoto, J.; Ono, T.; Maruyama, T.; Saito, S.; Iizima, M.; Kumamoto, A.

2006-12-01

latitudinal difference can be explained by considering that (1) the magnetic field line at the F2 peak which moved upward by the E x B drift (corresponding to the F3 peak or subsequently ionization ledge peak) in the vicinity of the dip equator is also crossing at that in the low dip latitude region and (2) a dip latitudinal difference of field aligned plasma diffusion effects; In the vicinity of the dip equator, since plasma at the upward drifted peak altitude diffuses aligned magnetic field line to higher altitude, plasma density at upward drifted peak decreases and becomes smaller immediately than the F2 peak existing at the usual altitude, then double peak structure is observable from the ground with shorter duration time and the ionization ledge structure might be formed in earlier local time. On the other hand, in the low latitude region, since plasma are transported from the vicinity of the dip equator, plasma density at upward drifted peak altitude is retained denser than that at usual F2 peak altitude for a longer time. Then double peak structure is observable from the ground with longer duration time.

Analysis of extreme ultraviolet spectra from laser produced rhenium plasmas

NASA Astrophysics Data System (ADS)

Wu, Tao; Higashiguchi, Takeshi; Li, Bowen; Suzuki, Yuhei; Arai, Goki; Dinh, Thanh-Hung; Dunne, Padraig; O'Reilly, Fergal; Sokell, Emma; Liu, Luning; O'Sullivan, Gerry

2015-08-01

Extreme ultraviolet spectra of highly-charged rhenium ions were observed in the 1-7 nm region using two Nd:YAG lasers with pulse lengths of 150 ps and 10 ns, respectively, operating at a number of laser power densities. The maximum focused peak power density was 2.6 × 1014 W cm-2 for the former and 5.5 × 1012 W cm-2 for the latter. The Cowan suite of atomic structure codes and unresolved transition array (UTA) approach were used to calculate and interpret the emission properties of the different spectra obtained. The results show that n = 4-n = 4 and n = 4-n = 5 UTAs lead to two intense quasi-continuous emission bands in the 4.3-6.3 nm and 1.5-4.3 nm spectral regions. As a result of the different ion stage distributions in the plasmas induced by ps and ns laser irradiation the 1.5-4.3 nm UTA peak moves to shorter wavelength in the ps laser produced plasma spectra. For the ns spectrum, the most populated ion stage during the lifetime of this plasma that could be identified from the n = 4-n = 5 transitions was Re23+ while for the ps plasma the presence of significantly higher stages was demonstrated. For the n = 4-n = 4 4p64dN-4p54dN+1 + 4p64dN-14f transitions, the 4d-4f transitions contribute mainly in the most intense 4.7-5.5 nm region while the 4p-4d subgroup gives rise to a weaker feature in the 4.3-4.7 nm region. A number of previously unidentified spectral features produced by n = 4-n = 5 transitions in the spectra of Re XVI to Re XXXIX are identified.

Understanding the amorphous-to-microcrystalline silicon transition in SiF{sub 4}/H{sub 2}/Ar gas mixtures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dornstetter, Jean-Christophe; LPICM-CNRS, Ecole Polytechnique, 91128 Palaiseau; Bruneau, Bastien

2014-06-21

We report on the growth of microcrystalline silicon films from the dissociation of SiF{sub 4}/H{sub 2}/Ar gas mixtures. For this growth chemistry, the formation of HF molecules provides a clear signature of the amorphous to microcrystalline growth transition. Depositing films from silicon tetrafluoride requires the removal of F produced by SiF{sub 4} dissociation, and this removal is promoted by the addition of H{sub 2} which strongly reacts with F to form HF molecules. At low H{sub 2} flow rates, the films grow amorphous as all the available hydrogen is consumed to form HF. Above a critical flow rate, corresponding tomore » the full removal of F, microcrystalline films are produced as there is an excess of atomic hydrogen in the plasma. A simple yet accurate phenomenological model is proposed to explain the SiF{sub 4}/H{sub 2} plasma chemistry in accordance with experimental data. This model provides some rules of thumb to achieve high deposition rates for microcrystalline silicon, namely, that increased RF power must be balanced by an increased H{sub 2} flow rate.« less

A comparison of the C III, O V, F VI, and Ne VII Delta n = 0 (2-2) line emissions from a laboratory plasma with theoretical predictions and astrophysical observations

NASA Technical Reports Server (NTRS)

Finkenthal, M.; Yu, . L.; Lippmann, S.; Huang, L. K.; Moos, H. W.; Stratton, B. C.; Bhatia, A. K.

1987-01-01

Spectra of the Delta n = 0 (2-2) transitions of Be I-like ions, C III, O V, F VI, and Ne VII emitted from the TEXT tokamak, were measured with photometrically calibrated instrumentation and compared to the predictions of several models which differ in their treatment of electron impact excitation, using either the distorted wave or R-matrix approach. It was found that the ions from C III to Ne VII were located near the edge of the plasma, at densities between 10 to the 12th and 13th/cu cm. The experimental line ratios were compared with several sets of computations. Agreement is obtained between the experimental data and computations by using the R-matrix technique. This leads to the conclusion that the effect resonances must be included in collision strength calculations, particularly at low nuclear charge. The results show that the line ratios studied may be used with confidence as electron density diagnostics for laboratory or astrophysical plasmas.

Measurements of electron density and temperature profiles in plasma produced by Nike KrF laser for laser plasma instability research

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Karasik, M.; Chan, L. Y.

2015-08-01

A grid image refractometer (GIR) has been implemented at the Nike krypton fluoride laser facility of the Naval Research Laboratory. This instrument simultaneously measures propagation angles and transmissions of UV probe rays (λ = 263 nm, Δt = 10 ps) refracted through plasma. We report results of the first Nike-GIR measurement on a CH plasma produced by the Nike laser pulse (˜1 ns FWHM) with the intensity of 1.1 × 1015 W/cm2. The measured angles and transmissions were processed to construct spatial profiles of electron density (ne) and temperature (Te) in the underdense coronal region of the plasma. Using an inversion algorithm developed for the strongly refracted rays, the deployed GIR system probed electron densities up to 4 × 1021 cm-3 with the density scale length of 120 μm along the plasma symmetry axis. The resulting ne and Te profiles are verified to be self-consistent with the measured quantities of the refracted probe light.

Measurements of electron density and temperature profiles in plasma produced by Nike KrF laser for laser plasma instability research.

PubMed

Oh, Jaechul; Weaver, J L; Karasik, M; Chan, L Y

2015-08-01

A grid image refractometer (GIR) has been implemented at the Nike krypton fluoride laser facility of the Naval Research Laboratory. This instrument simultaneously measures propagation angles and transmissions of UV probe rays (λ = 263 nm, Δt = 10 ps) refracted through plasma. We report results of the first Nike-GIR measurement on a CH plasma produced by the Nike laser pulse (∼1 ns FWHM) with the intensity of 1.1 × 10(15) W/cm(2). The measured angles and transmissions were processed to construct spatial profiles of electron density (ne) and temperature (Te) in the underdense coronal region of the plasma. Using an inversion algorithm developed for the strongly refracted rays, the deployed GIR system probed electron densities up to 4 × 10(21) cm(-3) with the density scale length of 120 μm along the plasma symmetry axis. The resulting n(e) and T(e) profiles are verified to be self-consistent with the measured quantities of the refracted probe light.

Observations of high-plasma density region in the inner coma of 67P/Churyumov-Gerasimenko during early activity

NASA Astrophysics Data System (ADS)

Yang, Lei; Paulsson, J. J. P.; Wedlund, C. Simon; Odelstad, E.; Edberg, N. J. T.; Koenders, C.; Eriksson, A. I.; Miloch, W. J.

2016-11-01

In 2014 September, as Rosetta transitioned to close bound orbits at 30 km from comet 67P/Churyumov-Gerasimenko, the Rosetta Plasma Consortium Langmuir probe (RPC-LAP) data showed large systematic fluctuations in both the spacecraft potential and the collected currents. We analyse the potential bias sweeps from RPC-LAP, from which we extract three sets of parameters: (1) knee potential, that we relate to the spacecraft potential, (2) the ion attraction current, which is composed of the photoelectron emission current from the probe as well as contributions from local ions, secondary emission, and low-energy electrons, and (3) an electron current whose variation is, in turn, an estimate of the electron density variation. We study the evolution of these parameters between 4 and 3.2 au in heliocentric and cometocentric frames. We find on September 9 a transition into a high-density plasma region characterized by increased knee potential fluctuations and plasma currents to the probe. In conjunction with previous studies, the early cometary plasma can be seen as composed of two regions: an outer region characterized by solar wind plasma, and small quantities of pick-up ions, and an inner region with enhanced plasma densities. This conclusion is in agreement with other RPC instruments such as RPC-MAG, RPC-IES and RPC-ICA, and numerical simulations.

Plasma density behavior with new graphite limiters in the Hefei Tokamak-7

DOE Office of Scientific and Technical Information (OSTI.GOV)

Asif, M.; Gao, X.; Li, J.

A new set of actively cooled toroidal double-ring graphite limiters has been developed in the Hefei Tokamak-7 (HT-7) [X. Gao et al., Phys. Plasmas 7, 2933 (2000)] for long pulse operation. The extension of operational region and density behavior with graphite (C) limiters have been studied in this paper. Extended high-density region at the high plasma current low-q{sub a} was obtained. The density profile with the C limiter was studied to compare with the previous molybdenum (Mo) limiter. The critical density of multifaceted asymmetric radiation from the edge (MARFE) onset is observed in the region of Z{sub eff}{sup 1/2}f{sub GW}=0.9{approx}1.2,more » where f{sub GW}=n{sub e}/n{sub GW}. (Here n{sub e} is the maximum line average electron density and n{sub GW} is the Greenwald density.) Under the same injected power, the critical density of MARFE onset with the new C limiter is much higher than the previous Mo limiter.« less

Moessbauer spectroscopy study on the corrosion resistance of plasma nitrided ASTM F138 stainless steel in chloride solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Souza, S.D. de; Olzon-Dionysio, M., E-mail: dmod@df.ufscar.br; Basso, R.L.O.

2010-10-15

Plasma nitriding of ASTM F138 stainless steel samples has been carried out using dc glow discharge under 80% H{sub 2}-20% N{sub 2} gas mixture, at 673 K, and 2, 4, and 7 h time intervals, in order to investigate the influence of treatment time on the microstructure and the corrosion resistance properties. The samples were characterized by scanning electron microscopy, glancing angle X-ray diffraction and conversion electron Moessbauer spectroscopy, besides electrochemical tests in NaCl aerated solution. A modified layer of about 6 {mu}m was observed for all the nitrided samples, independent of nitriding time. The X-ray diffraction analysis shows broadmore » {gamma}{sub N} phase peaks, signifying a great degree of nitrogen supersaturation. Besides {gamma}{sub N,} the Moessbauer spectroscopy results indicated the occurrence of {gamma}' and {epsilon} phases, as well as some other less important phases. Corrosion measurements demonstrate that the plasma nitriding time affects the corrosion resistance and the best performance is reached at 4 h treatment. It seems that the {epsilon}/{gamma}' fraction ratio plays an important role on the resistance corrosion. Additionally, the Moessbauer spectroscopy was decisive in this study, since it was able to identify and quantify the iron phases that influence the corrosion resistance of plasma nitrided ASTM F138 samples.« less

The effect of FeF2 on the magneto-optic response in FeF2/Fe/FeF2 sandwiches

NASA Astrophysics Data System (ADS)

Pištora, J.; Lesňák, M.; Lišková, E.; Višňovský, Š.; Harward, I.; Maslankiewicz, P.; Balin, K.; Celinski, Z.; Mistrík, J.; Yamaguchi, T.; Lopusnik, R.; Vlček, J.

2010-04-01

The room temperature optical constants n and k of MBE grown FeF2 films are reported. Because of poor chemical stability, FeF2 had to be coated with a protective Au layer. Reflection spectral ellipsometry in the photon energy range between 1.3 and 5.2 eV was performed on structures with a typical profile Au(0.5 nm)/FeF2(120 nm)/Au(30 nm)/Ag(20 nm)/Fe(0.6 nm) grown on GaAs(0 0 1) substrate. The spectra of n and k in FeF2 were subsequently employed in the design of FeF2/Fe/FeF2 sandwiches considered as magneto-optic (MO) sensors for weak microwave currents. Their MO response was evaluated using reflection MO (Kerr) spectroscopy at polar magnetization. The present results may be of interest in MO studies of magnetic nanostructures with Fe/FeF2/Fe, including MO magnetometry and MO magnetic domain imaging.

An EEG Finger-Print of fMRI deep regional activation.

PubMed

Meir-Hasson, Yehudit; Kinreich, Sivan; Podlipsky, Ilana; Hendler, Talma; Intrator, Nathan

2014-11-15

This work introduces a general framework for producing an EEG Finger-Print (EFP) which can be used to predict specific brain activity as measured by fMRI at a given deep region. This new approach allows for improved EEG spatial resolution based on simultaneous fMRI activity measurements. Advanced signal processing and machine learning methods were applied on EEG data acquired simultaneously with fMRI during relaxation training guided by on-line continuous feedback on changing alpha/theta EEG measure. We focused on demonstrating improved EEG prediction of activation in sub-cortical regions such as the amygdala. Our analysis shows that a ridge regression model that is based on time/frequency representation of EEG data from a single electrode, can predict the amygdala related activity significantly better than a traditional theta/alpha activity sampled from the best electrode and about 1/3 of the times, significantly better than a linear combination of frequencies with a pre-defined delay. The far-reaching goal of our approach is to be able to reduce the need for fMRI scanning for probing specific sub-cortical regions such as the amygdala as the basis for brain-training procedures. On the other hand, activity in those regions can be characterized with higher temporal resolution than is obtained by fMRI alone thus revealing additional information about their processing mode. Copyright © 2013 Elsevier Inc. All rights reserved.

Modeling electronegative plasma discharge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lichtenberg, A.J.; Lieberman, M.A.

Macroscopic analytic models for a three-component electronegative gas discharge are developed. Assuming the negative ions to be in Boltzmann equilibrium, a positive ion ambipolar diffusion equation is derived. The discharge consists of an electronegative core and electropositive edges. The electron density in the core is nearly uniform, allowing a parabolic approximation to the plasma profile to be employed. The resulting equilibrium equations are solved analytically and matched to a constant mobility transport model of an electropositive edge plasma. The solutions are compared to a simulation of a parallel-plane r.f. driven oxygen plasma for p = 50 mTorr and n{sub eo}=more » 2.4 x 10{sup 15} m{sup -3}. The ratio {alpha}{sub o} of central negative ion density to electron density, and the electron temperature T{sub e}, found in the simulation, are in reasonable agreement with the values calculated from the model. The model is extended to: (1) low pressures, where a variable mobility model is used in the electropositive edge region; and (2) high {alpha}{sub o} in which the edge region disappears. The inclusion of a second positive ion species, which can be very important in describing electronegative discharges used for materials processing, is a possible extension of the model.« less

Seasonal and Solar Activity Variations of f3 Layer and StF-4 F-Layer Quadruple Stratification) Near the Equatorial Region

NASA Astrophysics Data System (ADS)

Tardelli, A.; Fagundes, P. R.; Pezzopane, M.; Kavutarapu, V.

2016-12-01

The ionospheric F-layer shape and electron density peak variations depend on local time, latitude, longitude, season, solar cycle, geomagnetic activity, and electrodynamic conditions. In particular, the equatorial and low latitude F-layer may change its shape and peak height in a few minutes due to electric fields induced by propagation of medium-scale traveling ionospheric disturbances (MSTIDs) or thermospheric - ionospheric coupling. This F-layer electrodynamics feature characterizing the low latitudes is one of the most remarkable ionospheric physics research field. The study of multiple-stratification of the F-layer has the initial records in the mid of the 20th century. Since then, many studies were focused on F3 layer. The diurnal, seasonal and solar activity variations of the F3 layer characteristics have been investigated by several researchers. Recently, investigations on multiple-stratifications of F-layer received an important boost after the quadruple stratification (StF-4) was observed at Palmas (10.3°S, 48.3°W; dip latitude 5.5°S - near equatorial region), Brazil (Tardelli & Fagundes, JGR, 2015). This study present the latest findings related with the seasonal and solar activity characteristics of the F3 layer and StF-4 near the equatorial region during the period from 2002 to 2006. A significant connection between StF-4 and F3 layer has been noticed, since the StF-4 is always preceded and followed by an F3 layer appearance. However, the F3 layer and StF-4 present different seasonal and solar cycle variations. At a near equatorial station Palmas, the F3 layer shows the maximum and minimum occurrence during summer and winter seasons respectively. On the contrary, the StF-4 presents the maximum and minimum occurrence during winter and summer seasons respectively. While the F3 layer occurrence is not affected by solar cycle, the StF-4 appearance is instead more frequent during High Solar Activity (HSA).

Molecular Dynamic Simulation Reveals Damaging Impact of RAC1 F28L Mutation in the Switch I Region

PubMed Central

Sethumadhavan, Rao; Purohit, Rituraj

2013-01-01

Ras-related C3 botulinum toxin substrate 1 (RAC1) is a plasma membrane-associated small GTPase which cycles between the active GTP-bound and inactive GDP-bound states. There is wide range of evidences indicating its active participation in inducing cancer-associated phenotypes. RAC1 F28L mutation (RACF28L) is a fast recycling mutation which has been implicated in several cancer associated cases. In this work we have performed molecular docking and molecular dynamics simulation (~0.3 μs) to investigate the conformational changes occurring in the mutant protein. The RMSD, RMSF and NHbonds results strongly suggested that the loss of native conformation in the Switch I region in RAC1 mutant protein could be the reason behind its oncogenic transformation. The overall results suggested that the mutant protein attained compact conformation as compared to the native. The major impact of mutation was observed in the Switch I region which might be the crucial reason behind the loss of interaction between the guanine ring and F28 residue. PMID:24146998

CLAES CH4, N2O and CCL2F2 (F12) global data. [Cryogenic Array Etalon Spectrometer

NASA Technical Reports Server (NTRS)

Kumer, J. B.; Mergenthaler, J. L.; Roche, A. E.

1993-01-01

Zonal mean comparisons of CH4 (for altitude regions above the 1.35 ppmv contour), of N2O (above the 210 ppbv contour), and of F12 (above the 360 pptv contour) with UARS prelaunch climatology and with recent models shows reasonable agreement, and some interesting differences in the details of equatorial uplift and descent near the winter poles, including apparent north-south differences. Prominent features such as the double peaked uplift structure in the April-May SAMS data are clearly evident in all three CLAES tracers. Contours of SAMS CH4 and N2O occur mostly at higher pressures than in the CLAES data, presumably due in part to increased tropospheric content of these gases, and/or perhaps some dynamic difference associated with the 15 years time difference between the data sets. The CLAES F12 are the first long time base global data sets. These show more tropical uplift than climatology or models. This might suggest a somewhat shorter lifetime of F12 in the stratosphere than is currently accepted.

M2-F2 on ramp

NASA Image and Video Library

1966-02-24

The M2-F2 Lifting Body is seen here on the ramp at the NASA Dryden Flight Research Center. The success of Dryden's M2-F1 program led to NASA's development and construction of two heavyweight lifting bodies based on studies at NASA's Ames and Langley research centers -- the M2-F2 and the HL-10, both built by the Northrop Corporation. The "M" refers to "manned" and "F" refers to "flight" version. "HL" comes from "horizontal landing" and 10 is for the tenth lifting body model to be investigated by Langley. The first flight of the M2-F2 -- which looked much like the "F1" -- was on July 12, 1966. Milt Thompson was the pilot. By then, the same B-52 used to air launch the famed X-15 rocket research aircraft was modified to also carry the lifting bodies. Thompson was dropped from the B-52's wing pylon mount at an altitude of 45,000 feet on that maiden glide flight. The M2-F2 weighed 4,620 pounds, was 22 feet long, and had a width of about 10 feet. On May 10, 1967, during the sixteenth glide flight leading up to powered flight, a landing accident severely damaged the vehicle and seriously injured the NASA pilot, Bruce Peterson. NASA pilots and researchers realized the M2-F2 had lateral control problems, even though it had a stability augmentation control system. When the M2-F2 was rebuilt at Dryden and redesignated the M2-F3, it was modified with an additional third vertical fin -- centered between the tip fins -- to improve control characteristics. The M2-F2/F3 was the first of the heavy-weight, entry-configuration lifting bodies. Its successful development as a research test vehicle answered many of the generic questions about these vehicles. NASA donated the M2-F3 vehicle to the Smithsonian Institute in December 1973. It is currently hanging in the Air and Space Museum along with the X-15 aircraft number 1, which was its hangar partner at Dryden from 1965 to 1969.

First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430

PubMed Central

Waterhouse, Rikki N.; Nabulsi, Nabeel; Lin, Shu-Fei; Labaree, David; Ropchan, Jim; Tarabar, Sanela; DeMartinis, Nicholas; Ogden, Adam; Banerjee, Anindita; Huang, Yiyun; Carson, Richard E.

2016-01-01

This was a first-in-human study of the novel phosphodiesterase-2A (PDE2A) PET ligand 18F-PF-05270430. The primary goals were to determine the appropriate tracer kinetic model to quantify brain uptake and to examine the within-subject test–retest variability. Methods: In advance of human studies, radiation dosimetry was determined in nonhuman primates. Six healthy male subjects participated in a test–retest protocol with dynamic scans and metabolite-corrected input functions. Nine brain regions of interest were studied, including the striatum, white matter, neocortical regions, and cerebellum. Multiple modeling methods were applied to calculate volume of distribution (VT) and binding potentials relative to the nondisplaceable tracer in tissue (BPND), concentration of tracer in plasma (BPP), and free tracer in tissue (BPF). The cerebellum was selected as a reference region to calculate binding potentials. Results: The dosimetry study provided an effective dose of less than 0.30 mSv/MBq, with the gallbladder as the critical organ; the human target dose was 185 MBq. There were no adverse events or clinically detectable pharmacologic effects reported. Tracer uptake was highest in the striatum, followed by neocortical regions and white matter, and lowest in the cerebellum. Regional time–activity curves were well fit by multilinear analysis-1, and a 70-min scan duration was sufficient to quantify VT and the binding potentials. BPND, with mean values ranging from 0.3 to 0.8, showed the best intrasubject and intersubject variability and reliability. Test–retest variability in the whole brain (excluding the cerebellum) of VT, BPND, and BPP were 8%, 16%, and 17%, respectively. Conclusion: 18F-PF-05270430 shows promise as a PDE2A PET ligand, albeit with low binding potential values. PMID:27103022

Influence of electron injection into 27 cm audio plasma cell on the plasma diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haleem, N. A.; Ragheb, M. S.; Zakhary, S. G.

2013-08-15

In this article, the plasma is created in a Pyrex tube (L = 27 cm, φ= 4 cm) as a single cell, by a capacitive audio frequency (AF) discharge (f = 10–100 kHz), at a definite pressure of ∼0.2 Torr. A couple of tube linear and deviating arrangements show plasma characteristic conformity. The applied AF plasma and the injection of electrons into two gas mediums Ar and N{sub 2} revealed the increase of electron density at distinct tube regions by one order to attain 10{sup 13}/cm{sup 3}. The electrons temperature and density strengths are in contrast to each other. Whilemore » their distributions differ along the plasma tube length, they show a decaying sinusoidal shape where their peaks position varies by the gas type. The electrons injection moderates electron temperature and expands their density. The later highest peak holds for the N{sub 2} gas, at electrons injection it changes to hold for the Ar. The sinusoidal decaying density behavior generates electric fields depending on the gas used and independent of tube geometry. The effect of the injected electrons performs a responsive impact on electrons density not attributed to the gas discharge. Analytical tools investigate the interaction of the plasma, the discharge current, and the gas used on the electrodes. It points to the emigration of atoms from each one but for greater majority they behave to a preferred direction. Meanwhile, only in the linear regime, small percentage of atoms still moves in reverse direction. Traces of gas atoms revealed on both electrodes due to sheath regions denote lack of their participation in the discharge current. In addition, atoms travel from one electrode to the other by overcoming the sheaths regions occurring transportation of particles agglomeration from one electrode to the other. The electrons injection has contributed to increase the plasma electron density peaks. These electrons populations have raised the generated electrostatic fields assisting the elemental ions

Measurement of the proton structure function F2 ( x, Q2) in the low- x region at HERA

NASA Astrophysics Data System (ADS)

Abt, I.; Ahmed, T.; Andreev, V.; Andrieu, B.; Appuhn, R.-D.; Arpagaus, M.; Babaev, A.; Bärwolff, H.; Bán, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Bassler, U.; Beck, H. P.; Behrend, H.-J.; Belousov, A.; Berger, Ch.; Bergstein, H.; Bernardi, G.; Bernet, R.; Bertrand-Coremans, G.; Besançon, M.; Biddulph, P.; Binder, E.; Bischoff, A.; Bizot, J. C.; Blobel, V.; Borras, K.; Bosetti, P. C.; Boudry, V.; Bourdarios, C.; Brasse, F.; Braun, U.; Braunschweig, W.; Brisson, V.; Bruncko, D.; Büngener, L.; Bürger, J.; Büsser, F. W.; Buniatian, A.; Burke, S.; Buschhorn, G.; Campbell, A. J.; Carli, T.; Charles, F.; Clarke, D.; Clegg, A. B.; Colombo, M.; Coughlan, J. A.; Courau, A.; Coutures, Ch.; Cozzika, G.; Criegee, L.; Cvach, J.; Dagoret, S.; Dainton, J. B.; Danilov, M.; Dann, A. W. E.; Dau, W. D.; David, M.; Deffur, E.; Delcourt, B.; Del Buono, L.; Devel, M.; De Roeck, A.; Dingus, P.; Dollfus, C.; Dowell, J. D.; Dreis, H. B.; Drescher, A.; Duboc, J.; Düllmann, D.; Dünger, O.; Duhm, H.; Ebbinghaus, R.; Eberle, M.; Ebert, J.; Ebert, T. R.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichenberger, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellis, N. N.; Ellison, R. J.; Elsen, E.; Erdmann, M.; Evrard, E.; Favart, L.; Fedotov, A.; Feeken, D.; Felst, R.; Feltesse, J.; Fensome, I. F.; Ferencei, J.; Ferrarotto, F.; Flamm, K.; Flauger, W.; Fleischer, M.; Flügge, G.; Fomenko, A.; Fominykh, B.; Forbush, M.; Formánek, J.; Foster, J. M.; Franke, G.; Fretwurst, E.; Fuhrmann, P.; Gabathuler, E.; Gamerdinger, K.; Garvey, J.; Gayler, J.; Gellrich, A.; Gennis, M.; Genzel, H.; Gerhards, R.; Godfrey, L.; Goerlach, U.; Goerlich, L.; Goldberg, M.; Goodall, A. M.; Gorelov, I.; Goritchev, P.; Grab, C.; Grässler, H.; Grässler, R.; Greenshaw, T.; Greif, H.; Grindhammer, G.; Gruber, C.; Haack, J.; Haidt, D.; Hajduk, L.; Hamon, O.; Handschuh, D.; Hanlon, E. M.; Hapke, M.; Harjes, J.; Haydar, R.; Haynes, W. J.; Heatherington, J.; Hedberg, V.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Herma, R.; Herynek, I.; Hildesheim, W.; Hill, P.; Hilton, C. D.; Hladký, J.; Hoeger, K. C.; Huet, Ph.; Hufnagel, H.; Huot, N.; Ibbotson, M.; Itterbeck, H.; Jabiol, M.-A.; Jacholkowska, A.; Jacobsson, C.; Jaffre, M.; Jansen, T.; Jönsson, L.; Johannsen, K.; Johnson, D. P.; Johnson, L.; Jung, H.; Kalmus, P. I. P.; Kasarian, S.; Kaschowitz, R.; Kasselmann, P.; Kathage, U.; Kaufmann, H. H.; Kenyon, I. R.; Kermiche, S.; Keuker, C.; Kiesling, C.; Klein, M.; Kleinwort, C.; Knies, G.; Ko, W.; Köhler, T.; Kolanoski, H.; Kole, F.; Kolya, S. D.; Korbel, V.; Korn, M.; Kotska, P.; Kotelnikov, S. K.; Krasny, M. W.; Krehbiel, H.; Krücker, D.; Krüger, U.; Kubenka, J. P.; Küster, H.; Kuhlen, M.; Kurča, T.; Kurzhöfer, J.; Kuznik, B.; Lamarche, F.; Lander, R.; Landon, M. P. J.; Lange, W.; Langkau, R.; Lanius, P.; Laporte, J. F.; Lebedev, A.; Leuschner, A.; Leverenz, C.; Levonian, S.; Lewin, D.; Ley, Ch.; Lindner, A.; Lindström, G.; Linsel, F.; Lipinski, J.; Loch, P.; Lohmander, H.; Lopez, G. C.; Lüers, D.; Magnussen, N.; Malinovski, E.; Mani, S.; Marage, P.; Marks, J.; Marshall, R.; Martens, J.; Martin, R.; Martyn, H.-U.; Martyniak, J.; Masson, S.; Mavroidis, A.; Maxfield, S. J.; McMahon, S. J.; Mehta, A.; Meier, K.; Mercer, D.; Merz, T.; Meyer, C. A.; Meyer, H.; Meyer, J.; Mikocki, S.; Milone, V.; Monnier, E.; Moreau, F.; Moreels, J.; Morris, J. V.; Müller, K.; Murín, P.; Murray, S. A.; Nagovizin, V.; Naroska, B.; Naumann, Th.; Newton, D.; Neyret, D.; Nguyen, H. K.; Niebergall, F.; Nisius, R.; Nowak, G.; Noyes, G. W.; Nyberg, M.; Oberlack, H.; Obrock, U.; Olsson, J. E.; Orenstein, S.; Ould-Saada, F.; Pascaud, C.; Patel, G. D.; Peppel, E.; Peters, S.; Phillips, H. T.; Phillips, J. P.; Pichler, Ch.; Pilgram, W.; Pitzl, D.; Prell, S.; Prosi, R.; Rädel, G.; Raupach, F.; Rauschnabel, K.; Reimer, P.; Reinshagen, S.; Ribarics, P.; Riech, V.; Riedlberger, J.; Riess, S.; Rietz, M.; Robertson, S. M.; Robmann, P.; Roosen, R.; Rostovtsev, A.; Royon, C.; Rudowicz, M.; Ruffer, M.; Rusakov, S.; Rybicki, K.; Sahlmann, N.; Sanchez, E.; Sankey, D. P. C.; Savitsky, M.; Schacht, P.; Schleper, P.; von Schlippe, W.; Schmidt, C.; Schmidt, D.; Schmitz, W.; Schröder, V.; Schulz, M.; Schwab, B.; Schwind, A.; Scobel, W.; Seehausen, U.; Sell, R.; Semenov, A.; Shekelyan, V.; Sheviakov, I.; Shooshtari, H.; Shtarkov, L. N.; Siegmon, G.; Siewert, U.; Sirois, Y.; Skillicorn, I. O.; Smirnov, P.; Smith, J. R.; Smolik, L.; Soloviev, Y.; Spitzer, H.; Staroba, P.; Steenbock, M.; Steffen, P.; Steinberg, R.; Stella, B.; Stephens, K.; Stier, J.; Stösslein, U.; Strachota, J.; Straumann, U.; Struczinski, W.; Sutton, J. P.; Taylor, R. E.; Tchernyshov, V.; Thiebaux, C.; Thompson, G.; Tichomirov, I.; Truöl, P.; Turnau, J.; Tutas, J.; Urban, L.; Usik, A.; Valkar, S.; Valkarova, A.; Vallée, C.; van Esch, P.; Vartapetian, A.; Vazdik, Y.; Vecko, M.; Verrecchia, P.; Vick, R.; Villet, G.; Vogel, E.; Wacker, K.; Walker, I. W.; Walther, A.; Weber, G.; Wegener, D.; Wegner, A.; Wellisch, H. P.; Willard, S.; Winde, M.; Winter, G.-G.; Wolff, Th.; Womersley, L. A.; Wright, A. E.; Wulff, N.; Yiou, T. P.; Žáček, J.; Závada, P.; Zeitnitz, C.; Ziaeepour, H.; Zimmer, M.; Zimmermann, W.; Zomer, F.; H1 Collaboration

1993-10-01

A measurement of the proton structure function F2 ( x, Q2) is presented with about 1000 neutral current deep inelastic scattering events for Bjorken x in the range x ⋍ 10 -2 - 10 -4and Q 2 > 5 GeV2. The measurement is based on an integrated luminosity of 22.5 nb -1 recorded by the H1 detector in the first year of HERA operation. The structure function F2 ( x, Q2) shows a significant rise with decreasing x.

Interaction of cw CO2 laser radiation with plasma near-metallic substrate surface

NASA Astrophysics Data System (ADS)

Azharonok, V. V.; Astapchik, S. A.; Zabelin, Alexandre M.; Golubev, Vladimir S.; Golubev, V. S.; Grezev, A. N.; Filatov, Igor V.; Chubrik, N. I.; Shimanovich, V. D.

2000-07-01

Optical and spectroscopic methods were used in studying near-surface plasma that is formed under the effect CW CO2 laser of (2- 5)x106W/cm2 power density upon stainless steel in He and Ar shielding gases. The variation of plume spatial structure with time has been studied, the outflow of gas-vapor jets from the interaction area has been characterized. The spectra of plasma plume pulsations have been obtained for the frequency range Δf = 0-1 MHz. The temperature and electron concentration of plasma plume have been found under radiation effect upon the target of stainless steel. Consideration has been given to the most probable mechanisms of CW laser radiation-metal non-stationary interaction.

Reconsideration of F-layer seismic model in the south polar region

NASA Astrophysics Data System (ADS)

Ohtaki, T.; Kaneshima, S.

2017-12-01

Previously, we analyzed the seismic structure near the inner core boundary beneath Antarctica (Ohtaki et al., 2012). In the study, we determined the velocity of the lowermost outer core (F-layer) using amplitude ratio observations between the inner-core phase (PKIKP) and the inner-core grazing/diffracted phase (PKPbc/c-diff). Because the observations are not so sensitive to the F-layer structure, a constant velocity is assumed in the layer to simplify the model. The obtained model (SPR) has a flat velocity zone with a 75 km thick on the inner core boundary. With this F-layer structure and using travel times of these phases as well as the phase that reflects at the boundary, we determined the seismic structure of the inner core in the south polar region. However, a constant velocity layer is unrealistic, although it is reasonable assumption.Recently, we determined F-layer velocity structures more accurately using the combined observations of PKiKP-PKPbc differential travel times and of PKPbc/c-diff dispersion (Ohtaki et al., 2015, 2016). The former observation is sensitive to average velocity in the F-layer; the latter to velocity gradient in the layer. By analyzing these two observations together, we can determine the detailed velocity structure in the F-layer. The surveyed areas are beneath the Northeast Pacific and Australia. The seismic velocity models obtained are quite different between the two regions. Thus our results require laterally heterogeneous F-layer, and show that F-layer is more complicated than we ever imagined.Then there is one question; which structure is that of the south polar region close to? Unfortunately, the seismic waveforms that we analyzed in the previous study may not have quality high enough to analyze the PKiKP-PKPbc or PKPbc dispersion. However, it would be meaningful to reanalyze the amplitude data and reconsider the F-layer velocity there. And we also estimate how large slope of velocity can be acceptable for the F-layer velocity

CO2 Pulsed Laser Damage Mechanism and Plasma Effects (Focused Beam)

DTIC Science & Technology

1986-12-01

sensitive detection methods or large amounts of bombardment have to be used. For the energy ranges and materials associated with 14 nuclear fusion (this...F^ Introduction to Plasma Physics and Controlled Fussion , v 1, 2nd edition. Plenum Press, 1984. 20. Naval Postgraduate School Report NPS-61-82-002

Combined Raman and SEM study on CaF2 formed on/in enamel by APF treatments.

PubMed

Tsuda, H; Jongebloed, W L; Stokroos, I; Arends, J

1993-01-01

Raman spectra containing the distinct band at 322 cm-1 due to CaF2 or CaF2-like material formed in/on fluoridated bovine enamel were recorded using a micro-Raman spectrograph. Due to increasing levels of background fluorescence with increasing thickness of enamel, the Raman measurements were carried out on thin regions of wedged enamel sections. The distribution of the CaF2 or CaF2-like material was estimated using a simple model. The results indicate that 1/3 of the total CaF2 was concentrated within the narrow depth < 2 microns with high CaF2 concentrations (> 10 wt%), and that the majority of the CaF2 was distributed over the depths up to 26 microns (1 wt% CaF2). SEM observations on fractured fluoridated enamel confirmed that morphological changes were present in the depth range comparable to that of the high CaF2 concentration region expected from the Raman analysis. In deeper regions where lower concentration (< 10%) but a large amount of CaF2 was still expected, the SEM images failed to distinguish between the normal and fluoridated enamel. After KOH treatment, the Raman spectra did not show evidence of the CaF2 peak and the SEM micrographs also confirmed the removal of globules. The peak position of the Raman band of the CaF2 formed by the fluoridation was identical to that of pure CaF2. However, the linewidth was 23 cm-1 (FWHM) and a factor of 2 broader than that of pure CaF2 (12 cm-1). This implies that the lattice dynamics of the CaF2 formed by fluoridation is different from of pure CaF2, and that the material formed is 'CaF2-like' or 'disordered CaF2'.

The Relation Between Magnetospheric State Parameters and the Occurrence of Plasma Depletion Events in the Night-Time Mid-Latitude F-Region

NASA Technical Reports Server (NTRS)

Seker, Ilgin; Fung, Shing F.; Mathews, John D.

2010-01-01

Studies using all-sky imagers have revealed the presence of various ionospheric irregularities in the night-time mid-latitude F-region. The most prevalent and well known of these are the Medium Scale Traveling Ionospheric Disturbances (MSTIDs) that usually occur when the geomagnetic activity is low, and mid-latitude spread-F plumes that are often observed when the geomagnetic activity is high. The inverse and direct relations between geomagnetic activity (particularly Kp) and the occurrence rate of MSTIDs and midlatitude plumes, respectively, have been observed by several studies using different instruments. In order to understand the underlying causes of these two relations, it is illuminating to better characterize the occurrence of MSTIDs and plumes using multiple magnetospheric state parameters. Here we statistically compare multiple geomagnetic driver and response parameters (such as Kp, AE, Dst, and solar wind parameters) with the occurrence rates of night-time MSTIDs and plumes observed using an all-sky imager at Arecibo Observatory (AO) between 2003 and 2008. The results not only allow us to better distinguish MSTIDs and plumes, but also shed further light on the generation mechanism and electrodynamics of these two different phenomena occurring at night-time in the mid-latitude F-region.

Effect of source frequency and pulsing on the SiO2 etching characteristics of dual-frequency capacitive coupled plasma

NASA Astrophysics Data System (ADS)

Kim, Hoe Jun; Jeon, Min Hwan; Mishra, Anurag Kumar; Kim, In Jun; Sin, Tae Ho; Yeom, Geun Young

2015-01-01

A SiO2 layer masked with an amorphous carbon layer (ACL) has been etched in an Ar/C4F8 gas mixture with dual frequency capacitively coupled plasmas under variable frequency (13.56-60 MHz)/pulsed rf source power and 2 MHz continuous wave (CW) rf bias power, the effects of the frequency and pulsing of the source rf power on the SiO2 etch characteristics were investigated. By pulsing the rf power, an increased SiO2 etch selectivity was observed with decreasing SiO2 etch rate. However, when the rf power frequency was increased, not only a higher SiO2 etch rate but also higher SiO2 etch selectivity was observed for both CW and pulse modes. A higher CF2/F ratio and lower electron temperature were observed for both a higher source frequency mode and a pulsed plasma mode. Therefore, when the C 1s binding states of the etched SiO2 surfaces were investigated using X-ray photoelectron spectroscopy (XPS), the increase of C-Fx bonding on the SiO2 surface was observed for a higher source frequency operation similar to a pulsed plasma condition indicating the increase of SiO2 etch selectivity over the ACL. The increase of the SiO2 etch rate with increasing etch selectivity for the higher source frequency operation appears to be related to the increase of the total plasma density with increasing CF2/F ratio in the plasma. The SiO2 etch profile was also improved not only by using the pulsed plasma but also by increasing the source frequency.

Role of plasma-induced defects in the generation of 1/f noise in graphene

NASA Astrophysics Data System (ADS)

Cultrera, Alessandro; Callegaro, Luca; Marzano, Martina; Ortolano, Massimo; Amato, Giampiero

2018-02-01

It has already been reported that 1/f noise in graphene can be dominated by fluctuations of charge carrier mobility. We show here that the increasing damage induced by oxygen plasma on graphene samples result in two trends: at low doses, the magnitude of the 1/f noise increases with the dose; and at high doses, it decreases with the dose. This behaviour is interpreted in the framework of 1/f noise generated by carrier mobility fluctuations where the concentration of mobility fluctuation centers and the mean free path of the carriers are competing factors.

Prediction of plasma-induced damage distribution during silicon nitride etching using advanced three-dimensional voxel model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuboi, Nobuyuki, E-mail: Nobuyuki.Kuboi@jp.sony.com; Tatsumi, Tetsuya; Kinoshita, Takashi

2015-11-15

The authors modeled SiN film etching with hydrofluorocarbon (CH{sub x}F{sub y}/Ar/O{sub 2}) plasma considering physical (ion bombardment) and chemical reactions in detail, including the reactivity of radicals (C, F, O, N, and H), the area ratio of Si dangling bonds, the outflux of N and H, the dependence of the H/N ratio on the polymer layer, and generation of by-products (HCN, C{sub 2}N{sub 2}, NH, HF, OH, and CH, in addition to CO, CF{sub 2}, SiF{sub 2}, and SiF{sub 4}) as ion assistance process parameters for the first time. The model was consistent with the measured C-F polymer layer thickness,more » etch rate, and selectivity dependence on process variation for SiN, SiO{sub 2}, and Si film etching. To analyze the three-dimensional (3D) damage distribution affected by the etched profile, the authors developed an advanced 3D voxel model that can predict the time-evolution of the etched profile and damage distribution. The model includes some new concepts for gas transportation in the pattern using a fluid model and the property of voxels called “smart voxels,” which contain details of the history of the etching situation. Using this 3D model, the authors demonstrated metal–oxide–semiconductor field-effect transistor SiN side-wall etching that consisted of the main-etch step with CF{sub 4}/Ar/O{sub 2} plasma and an over-etch step with CH{sub 3}F/Ar/O{sub 2} plasma under the assumption of a realistic process and pattern size. A large amount of Si damage induced by irradiated hydrogen occurred in the source/drain region, a Si recess depth of 5 nm was generated, and the dislocated Si was distributed in a 10 nm deeper region than the Si recess, which was consistent with experimental data for a capacitively coupled plasma. An especially large amount of Si damage was also found at the bottom edge region of the metal–oxide–semiconductor field-effect transistors. Furthermore, our simulation results for bulk fin-type field-effect transistor side

Sustainment Study of Flipped Spherical Torus Plasmas on HIST

NASA Astrophysics Data System (ADS)

Takamiya, T.; Nagata, M.; Kawami, K.; Hasegawa, H.; Fukumoto, N.; Uyama, T.; Masamune, S.; Iida, M.; Katsurai, M.

2003-10-01

We have discovered that helicity-driven ST plasmas relax toward the flipped state by decreasing the external toroidal field and reversing its sign in time [1]. From the viewpoint of coaxial helicity injection (CHI) current drive, it is conceivable that the flipped ST (F-ST), which consists of only closed flux surfaces, compares favorably with the normal ST. We have investigated the sustainment mechanism of the F-ST plasma. The helicity-driven relaxed theory shows that there exist the mixed states of ST and F-ST in the flux conserver. Helicity is transferred to F-ST through the ST with coupling with gun electrodes. It has been found that magnetic reconnection between the toroidal magnetic field plays important role in the sustainment of the F-ST. The magnetic field in the outer edge region shows regular oscillations which have a large amplitude of the n=1 mode. The core region of the F-ST seems to be relatively stable. [1] M. Nagata, et al., Phys. Rev. Lett. 90, 225001 (2003)

Formation of metal nanoparticles in MgF2, CaF2 and BaF2 crystals under the electron beam irradiation

NASA Astrophysics Data System (ADS)

Bochkareva, Elizaveta S.; Sidorov, Alexander I.; Yurina, Uliana V.; Podsvirov, Oleg A.

2017-07-01

It is shown experimentally that electron beam action with electrons energies of 50 and 70 keV on MgF2, CaF2 and BaF2 crystals results in local formation in the crystal near-surface layer of Mg, Ca or Ba nanoparticles which possess plasmon resonance. In the case of MgF2 spheroidal nanoparticles are formed, in the cases of CaF2 and BaF2 - spherical. The formation of metal nanoparticles is confirmed by computer simulation in dipole quasistatic approximation. The dependence of absorption via electron irradiation dose is non-linear. It is caused by the increase of nanoparticles concentration and by the increase of nanoparticles sizes during irradiation. In the irradiated zones of MgF2 crystals, for irradiation doses less than 80 mC/cm2, the intense luminescence in a visible range appears. The practical application of fabricated composite materials for multilevel optical information recording is discussed.

Dusty plasma in the region of the lunar terminator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popel, S. I., E-mail: popel@iki.rssi.ru; Zelenyi, L. M.; Atamaniuk, B.

2016-05-15

Dusty plasma in the region of the lunar terminator is considered. It is shown that, in this region, a structure resembling a plasma sheath forms near the lunar surface. This sheath creates a potential barrier, due to which electrons over the illuminated part of the Moon are confined by electrostatic forces. The width of the sheath-like structure is on the order of the ion Debye length. In this structure, significant (about several hundred V/m) electric fields arise, which lift charged micron-size dust grains to heights of several tens of centimeters. The suggested effect may be used to explain the glowmore » observed by the Surveyor spacecraft over the lunar terminator.« less

Plasma observations near Saturn - Initial results from Voyager 2

NASA Technical Reports Server (NTRS)

Bridge, H. S.; Bagenal, F.; Belcher, J. W.; Lazarus, A. J.; Mcnutt, R. L.; Sullivan, J. D.; Gazis, P. R.; Hartle, R. E.; Ogilvie, K. W.; Scudder, J. D.

1982-01-01

Results of plasma measurements made by Voyager 2 in the vicinity of Saturn are discussed and compared with those made by Pioneer 11 and Voyager 1 in a more limited range of latitudes. The initial bow shock crossing on the inbound trajectory closely agreed with the shock position inferred from the external ram pressure in the solar wind, although boundaries on the outbound pass were much further out than expected. Magnetospheric plasma observations reveal the presence of (1) shocked solar wind plasma in the magnetosheath between 30 and 22 Saturn radii; (2) a variable density region between 17 Saturn radii and the magnetopause; (3) an extended thick plasma sheet between 17 and 7 Saturn radii; and (4) an inner plasma torus probably originating from local sources. The ratio of heavy to light ions was observed to vary with distance to the equatorial plane in the dayside magnetosphere, with the heavy ions, probably O(+), more closely confined to the equatorial plane. The plasma data also account for the observed inner boundary of the neutral hydrogen torus discovered by Voyager 1.

ITO-MgF2 Film Development for PowerSphere Polymer Surface Protection

NASA Technical Reports Server (NTRS)

Hambourger, Paul D.; Kerslake, Thomas W.; Waters, Deborah L.

2004-01-01

Multi-kilogram class microsatellites with a PowerSphere electric power system are attractive for fulfilling a variety of potential NASA missions. However, PowerSphere polymer surfaces must be coated with a film that has suitable electrical sheet resistivity for electrostatic discharge control, be resistant to atomic oxygen attack, be transparent to ultraviolet light for composite structure curing and resist ultraviolet light induced darkening for efficient photovoltaic cell operation. In addition, the film must be tolerant of polymer layer folding associated with launch stowage of PowerSphere inflatable structures. An excellent film material candidate to meet these requirements is co-sputtered, indium oxide (In2O3) - tin oxide (SnO2), known as 'ITO', and magnesium fluoride (MgF2). While basic ITO-MgF2 film properties have been the subject of research over the last decade, further research is required in the areas of film durability for space-inflatable applications and precise film property control for large scale commercial production. In this paper, the authors present film durability results for a folded polymer substrate and film resistance to vacuum UV darkening. The authors discuss methods and results in the area of film sheet resistivity measurement and active control, particularly dual-channel, plasma emission line measurement of ITO and MgF2 plasma sources. ITO-MgF2 film polymer coupon preparation is described as well as film deposition equipment, procedures and film characterization. Durability testing methods are also described. The pre- and post-test condition of the films is assessed microscopically and electrically. Results show that an approx. 500A ITO-18vol% MgF2 film is a promising candidate to protect PowerSphere polymer surfaces for Earth orbit missions. Preliminary data also indicate that in situ film measurement methods are promising for active film resistivity control in future large scale production. Future film research plans are also

Plasma characteristics in the discharge region of a 20 A emission current hollow cathode

NASA Astrophysics Data System (ADS)

Mingming, SUN; Tianping, ZHANG; Xiaodong, WEN; Weilong, GUO; Jiayao, SONG

2018-02-01

Numerical calculation and fluid simulation methods were used to obtain the plasma characteristics in the discharge region of the LIPS-300 ion thruster’s 20 A emission current hollow cathode and to verify the structural design of the emitter. The results of the two methods indicated that the highest plasma density and electron temperature, which improved significantly in the orifice region, were located in the discharge region of the hollow cathode. The magnitude of plasma density was about 1021 m-3 in the emitter and orifice regions, as obtained by numerical calculations, but decreased exponentially in the plume region with the distance from the orifice exit. Meanwhile, compared to the emitter region, the electron temperature and current improved by about 36% in the orifice region. The hollow cathode performance test results were in good agreement with the numerical calculation results, which proved that that the structural design of the emitter and the orifice met the requirements of a 20 A emission current. The numerical calculation method can be used to estimate plasma characteristics in the preliminary design stage of hollow cathodes.

Uncertainties in estimates of fAPAR for photosynthesis (fAPARPSN) in tropical, Arctic/boreal, coastal, and wetland-dominant regions when approximated with fAPARcanopy and NDVI

NASA Astrophysics Data System (ADS)

Zhang, Q.; Yao, T.

2016-12-01

The climate is affected by the land surface through regulating the exchange of mass and energy with the atmosphere. The energy that reaches the land surface has three pathways: (1) reflected into atmosphere; (2) absorbed for photosynthesis; and (3) discarded as latent and sensible heat or emitted as fluorescence. Vegetation removes CO2 from the atmosphere during the process of photosynthesis, but also releases CO2 back into the atmosphere through the process of respiration. The complex set of vegetation-soil-atmosphere interactions requires that a realistic land-surface parameterization be included in any climate model or general circulation model (GCM) to accurately simulate canopy photosynthesis and stomatal conductance.We retrieve fraction of PAR absorbed by chlorophyll (fAPARchl) with an advanced canopy-leaf-soil-snow-water coupled radiative transfer model. Most ecological models and land-surface models that simulate vegetation GPP with remote sensing data utilize fraction of PAR absorbed by the whole canopy (fAPARcanopy). However, only the PAR absorbed by chlorophyll is potentially available for photosynthesis since the PAR absorbed by non-photosynthetic vegetation section (NPV) of the canopy is not used for photosynthesis. Therefore, fAPARchl (rather than fAPARcanopy) should be utilized to estimate fAPAR for photosynthesis (fAPARPSN), and thus in GPP simulation. Globally selected sites include those sites in tropical, Arctic/boreal, coastal, and wetland-dominant regions. The fAPARchl and fAPARcanopy products for a surrounding area 50 km x 50 km of each site are mapped. The fAPARchl is utilized to estimate GPP, and compared to tower flux GPP for validation. The GPP estimation performance with fAPARchl is also compared with the GPP estimation performance with MOD15A2 FPAR. The fAPARchl product is further implemented into ecological models and land-surface models to simulate vegetation GPP. NDVI is the other proxy of fAPARPSN in GPP estimation. We quantify the

Detection of RSV Antibodies in Human Plasma by Enzyme Immunoassays.

PubMed

Jadhao, Samadhan J; Anderson, Larry J

2016-01-01

Enzyme immunoassays (EIAs) to detect and quantify antibodies against respiratory syncytial virus (RSV) and RSV proteins in human plasma or sera are described. The first EIA uses RSV lysate antigens produced in HEp-2 cell line. The second EIA uses RSV F or G gene-expressed antigen in HEp-2 cells. The third EIA uses 30-amino acid synthetic peptides from central conserved region of G protein of RSV A2 or RSV B1 virus and a peptide from the SARS CoV nucleoprotein as a negative control peptide. All three EIAs have been evaluated for detecting and quantifying the respective antibodies in human sera or plasma.

A region of intense plasma wave turbulence on auroral field lines

NASA Technical Reports Server (NTRS)

Gurnett, D. A.; Frank, L. A.

1976-01-01

This report presents a detailed study of the plasma wave turbulence observed by HAWKEYE-1 and IMP-6 on high latitude auroral field lines and investigates the relationship of this turbulence to magnetic field and plasma measurements obtained in the same region.

Fabrication and Characterization of Plasma-Sprayed Carbon-Fiber-Reinforced Aluminum Composites

NASA Astrophysics Data System (ADS)

Xiong, Jiang-tao; Zhang, Hao; Peng, Yu; Li, Jing-long; Zhang, Fu-sheng

2018-04-01

Carbon fiber ( C f)/Al specimens were fabricated by plasma-spraying aluminum powder on unidirectional carbon fiber bundles (CFBs) layer by layer, followed by a densification heat treatment process. The microstructure and chemical composition of the C f/Al composites were examined by scanning electron microscopy and energy-dispersive spectrometry. The CFBs were completely enveloped by aluminum matrix, and the peripheral regions of the CFBs were wetted by aluminum. In the wetted region, no significant Al4C3 reaction layer was found at the interface between the carbon fibers and aluminum matrix. The mechanical properties of the C f/Al specimens were evaluated. When the carbon fiber volume fraction (CFVF) was 9.2%, the ultimate tensile strength (UTS) of the C f/Al composites reached 138.3 MPa with elongation of 4.7%, 2.2 times the UTS of the Al matrix (i.e., 63 MPa). This strength ratio (between the UTS of C f/Al and the Al matrix) is higher than for most C f/Al composites fabricated by the commonly used method of liquid-based processing at the same CFVF level.

The collisional drift mode in a partially ionized plasma. [in the F region

NASA Technical Reports Server (NTRS)

Hudson, M. K.; Kennel, C. F.

1974-01-01

The structure of the drift instability was examined in several density regimes. Let sub e be the total electron mean free path, k sub z the wave-vector component along the magnetic field, and the ratio of perpendicular ion diffusion to parallel electron streaming rates. At low densities (k sub z lambda 1) the drift mode is isothermal and should be treated kineticly. In the finite heat conduction regime square root of m/M k sub z Lambda sub 1) the drift instability threshold is reduced at low densities and increased at high densities as compared to the isothermal threshold. Finally, in the energy transfer limit (k sub z kambda sub e square root of m/M) the drift instability behaves adiabatically in a fully ionized plasma and isothermally in a partially ionized plasma for an ion-neutral to Coulomb collision frequency ratio.

Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice.

PubMed

Iglesias, Ainhoa; Murga, Matilde; Laresgoiti, Usua; Skoudy, Anouchka; Bernales, Irantzu; Fullaondo, Asier; Moreno, Bernardino; Lloreta, José; Field, Seth J; Real, Francisco X; Zubiaga, Ana M

2004-05-01

E2F transcription factors are thought to be key regulators of cell growth control. Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo. E2F1/E2F2 compound-mutant mice develop nonautoimmune insulin-deficient diabetes and exocrine pancreatic dysfunction characterized by endocrine and exocrine cell dysplasia, a reduction in the number and size of acini and islets, and their replacement by ductal structures and adipose tissue. Mutant pancreatic cells exhibit increased rates of DNA replication but also of apoptosis, resulting in severe pancreatic atrophy. The expression of genes involved in DNA replication and cell cycle control was upregulated in the E2F1/E2F2 compound-mutant pancreas, suggesting that their expression is repressed by E2F1/E2F2 activities and that the inappropriate cell cycle found in the mutant pancreas is likely the result of the deregulated expression of these genes. Interestingly, the expression of ductal cell and adipocyte differentiation marker genes was also upregulated, whereas expression of pancreatic cell marker genes were downregulated. These results suggest that E2F1/E2F2 activity negatively controls growth of mature pancreatic cells and is necessary for the maintenance of differentiated pancreatic phenotypes in the adult.

Growth of electron plasma waves above and below f(p) in the electron foreshock

NASA Technical Reports Server (NTRS)

Cairns, Iver H.; Fung, Shing F.

1988-01-01

This paper investigates the conditions required for electron beams to drive wave growth significantly above and below the electron plasma frequency, f(p), by numerically solving the linear dispersion equation. It is shown that kinetic growth well below f(p) may occur over a broad range of frequencies due to the beam instability, when the electron beam is slow, dilute, and relatively cold. Alternatively, a cold or sharp feature at low parallel velocities in the distribution function may drive kinetic growth significantly below f(p). Kinetic broadband growth significantly above f(p) is explained in terms of faster warmer beams. A unified qualitative theory for the narrow-band and broad-band waves is proposed.

Plasma Profile Measurements for Laser Fusion Research with the Nike KrF Laser

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Serlin, V.; Obenschain, S. P.

2015-11-01

The grid image refractometer of the Nike laser facility (Nike-GIR) has demonstrated the capability of simultaneously measuring electron density (ne) and temperature (Te) profiles of coronal plasma. For laser plasma instability (LPI) research, the first Nike-GIR experiment successfully measured the plasma profiles in density regions up to ne ~ 4 ×1021 cm-3 (22% of the critical density for 248 nm light of Nike) using an ultraviolet probe laser (λp = 263 nm). The probe laser has been recently replaced with a shorter wavelength laser (λp = 213 nm, a 5th harmonic of the Nd:YAG laser) to diagnose a higher density region. The Nike-GIR system is being further extended to measure plasma profiles in the on-going experiment using 135°-separated Nike beam arrays for the cross-beam energy transfer (CBET) studies. We present an overview of the extended Nike-GIR arrangements and a new numerical algorithm to extract self-consistant plasma profiles with the measured quantities. Work supported by DoE/NNSA.

VUV Spectra observed in C-2 FRC plasma

NASA Astrophysics Data System (ADS)

Osin, Dmitry; Douglass, Jon; Tuszewski, Michel; TAE Team

2014-10-01

A grazing incidence flat-field spectrometer was installed for observation of vuv-spectra in C-2 FRC experiment. Wavelength calibration was done by observing spectra of six different gases produced by a hollow-cathode discharge lamp . In addition, in-situ calibration and alignment were performed utilizing neutral-beam heated gases. Wavelength regions between 16 nm and 170 nm was investigated with accuracy of about 0.02 nm. VUV-spectral lines of the most abundant impurity ions were identified both for Plasma Gun and C-2 plasmas. In addition to D spectrum, strong lines of O III-VI, N IV-V, C II-III, and Fe II ions were observed during the plasma lifetime. VUV radiative power losses within energy range from 7.3 eV to 81 eV were estimated based on the calculated FRC dimensions.

Study of structure and antireflective properties of LaF3/HfO2/SiO2 and LaF3/HfO2/MgF2 trilayers for UV applications

NASA Astrophysics Data System (ADS)

Marszalek, K.; Jaglarz, J.; Sahraoui, B.; Winkowski, P.; Kanak, J.

2015-01-01

The aim of this paper is to study antireflective properties of the tree-layer systems LaF3/HfO2/SiO2 and LaF3/HfO2/MgF2 deposited on heated optical glass substrates. The films were evaporated by the use two deposition techniques. In first method oxide films were prepared by means of e-gun evaporation in vacuum of 5 × 10-5 mbar in the presence of oxygen. The second was used for the deposition of fluoride films. They were obtained by means of thermal source evaporation. Simulation of reflectance was performed for 1M2H1L (Quarter Wavelength Optical Thickness) film stack on an optical quartz glass with the refractive index n = 1.46. The layer thickness was optimized to achieve the lowest light scattering from glass surface covered with dioxide and fluoride films. The values of the interface roughness were determined through atomic force microscopy measurements. The essence of performed calculation was to find minimum reflectance of light in wide ultraviolet region. The spectral dispersion of the refractive index needed for calculations was determined from ellipsometric measurements using the spectroscopic ellipsometer M2000. Additionally, the total reflectance measurements in integrating sphere coupled with Perkin Elmer 900 spectrophotometer were performed. These investigations allowed to determine the influence of such film features like surface and interface roughness on light scattering.

Plasma diagnostics package. Volume 2: Spacelab 2 section, part A

NASA Technical Reports Server (NTRS)

Pickett, Jolene S. (Compiler); Frank, L. A. (Compiler); Kurth, W. S. (Compiler)

1988-01-01

This volume (2), which consists of two parts (A and B), of the Plasma Diagnostics Package (PDP) Final Science Report contains a summary of all of the data reduction and scientific analyses which were performed using PDP data obtained on STS-51F as a part of the Spacelab 2 (SL-2) payload. This work was performed during the period of launch, July 29, l985, through June 30, l988. During this period the primary data reduction effort consisted of processing summary plots of the data received by 12 of the 14 instruments located on the PDP and submitting these data to the National Space Science Data Center (NSSDC). The scientific analyses during the performance period consisted of follow-up studies of shuttle orbiter environment and orbiter/ionosphere interactions and various plasma particle and wave studies which dealt with data taken when the PDP was on the Remote Manipulator System (RMS) arm and when the PDP was in free flight. Of particular interest during the RMS operations and free flight were the orbiter wake studies and joint studies of beam/plasma interactions with the SL-2 Fast Pulse Electron Generator (FPEG) of the Vehicle Charging and Potential Investigation (VCAP). Internal reports, published papers and presentations which involve PDP/SL-2 data are listed in Sections 3 and 4. A PDP/SL-2 scientific results meeting was held at the University of Iowa on June 10, l986. This meeting was attended by most of the PDP and VCAP investigators and provided a forum for discussing and comparing the various results, particularly with regard to the PDP free flight.

Hot coronal plasma phenomena disclosed, classified and studied in the SPIRIT experiment on CORONAS-F mission

NASA Astrophysics Data System (ADS)

Urnov, Alexander; Kuzin, Sergey; Bogachev, Sergey; Goryaev, Farid; Dennis, Brian; Reva, Anton; Shestov, Sergey; Soloviev, Alexander; Zhitnik, Igor

The advent of XUV full-Sun monochromatic imaging spectroscopy in the SPIRIT experiment on CORONAS-F (2001-2005) helped to reveal highly dynamic 4 -20 MK coronal plasma structures characterized by various sizes from 6" through 0.3 solar radius and lifetimes from several minutes to several days. Due to the high dynamic range (more than four orders of magnitude) of the X-Ray detector, the monochromatic images in the Mg XII ion line at 8.42 ˚ allowed the A whole Sun light curves of the GOES 1-8˚ channel to be decomposed over the temporal flux A profiles of individual X-Ray sources. Thus, the GOES background emission was shown to be the result of a superposition of a series of low intensity "elemental bursts" each lasting for 10-20 min and recurring at different locations on the solar disk. A new phenomenon of small size, short-lived X-ray "hot spots" (hot X-ray bright points, HXBP) has been disclosed in addition to the previously reported giant post-eruptive sources ("spiders"). The classification has been proposed of hot plasma phenomena by their spatial and temporal properties being the "markers" of energy storage and release sites for all observable X-ray sources. It was also shown that these sources are characterized by complex topology rather than by the strength of the magnetic field since they associated only with active region loop systems comprising of more than two spots. Diagnostic techniques developed on the basis of monochromatic and broad band data simultaneously measured on CORONAS-F, GOES, and RHESSI were used to obtain space-time dynamics of the temperature and density content for hot coronal plasma structures in the range logT=6.0 -7.2. A theoretical description of the spider phenomena based on long-duration recurrently flaring giant magneto-plasma formations, is given using the Chandrasekhar-Prendergast model of a spherical magnetic vortex, generalized to account for density perturbations. This model presents a sequence of magnetic toroidal

Diagnostic techniques in thermal plasma processing, part 2, volume 2

NASA Astrophysics Data System (ADS)

Boulos, M.; Fauchais, P.; Pfender, E.

1986-02-01

Techniques for diagnostics for thermal plasmas are discussed. These include both optical techniques and in-flight measurements of particulate matter. In the core of the plasma, collisional excitation of the various chemical species is so strong that the population of the corresponding quantum levels becomes high enough for net emission from the plasma. In that case, the classical methods of emission spectroscopy may be applied. But in the regions where the temperatures are below 4000K (these regions are of primary importance for plasma processing), the emission from the plasma is no longer sufficient for emission spectroscopy. In this situation, the population of excited levels must be increased by the absorption of the light from an external source. Such sources, as for example pulsed tunable dye lasers, are now commercially available. The use of such new devices leads to various techniques such as laser induced fluorescence (LIF) or Coherent Anti Stockes Raman Spectroscopy (CARS) that can be used for analyzing plasmas. Particle velocity measurements can be achieved by photography and laser Doppler anemometry. Particle flux measurements are typically achieved by collecting particles on a substrate. Particle size measurements are based on intensity of scattered light.

On the application of CaF2:Eu and SrF2:Eu phosphors in LED based phototherapy lamp

NASA Astrophysics Data System (ADS)

Belsare, P. D.; Moharil, S. V.; Joshi, C. P.; Omanwar, S. K.

2013-06-01

In the last few years the interest of scientific community has been increased towards solid state lighting based on LEDs because of their superior advantages over the conventional fluorescent lamps. As the GaN based LEDs are easily available efforts of the researchers are now on making the new phosphors which are excitable in the near UV region (360-400nm) for solid state lighting. This paper reports the photoluminescence characteristics of CaF2:Eu and SrF2:Eu phosphor prepared by wet chemical method. The violet emission of these phosphors with near UV excitation can be useful in making a phototherapy lamp based on LEDs for treating various skin diseases like acne vulgaris and hyperbilirubinemia.

Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself1234

PubMed Central

Dorjgochoo, Tsogzolmaa; Gao, Yu-Tang; Chow, Wong-Ho; Shu, Xiao-ou; Yang, Gong; Cai, Qiuyin; Rothman, Nathaniel; Cai, Hui; Li, Honglan; Deng, Xinqing; Franke, Adrian; Roberts, L Jackson; Milne, Ginger; Zheng, Wei; Dai, Qi

2012-01-01

Background: There is limited literature on the contributors to isoprostane metabolite 2,3-dinor-5,6-dihydro-15-F2t-isoprostane (15-F2t-IsoP-M) compared with F2-isoprostanes (F2-IsoPs) as an oxidative stress biomarker. Objective: The objective of this study was to investigate whether plasma concentrations of antioxidants, urinary excretion rates of polyphenols, and antioxidants in food and dietary supplements are attributable to both urinary F2-IsoP and 15-F2t-IsoP-M concentrations. Design: Dietary intake information and blood and urine samples were obtained from 845 healthy middle-aged and elderly female participants of the Shanghai Women's Health Study. Urinary isoprostanes (F2-IsoPs and 15-F2t-IsoP-M) were measured and adjusted for creatinine concentrations. Results: Urinary 15-F2t-IsoP-M and F2-IsoP concentrations were lower in subjects who used a multivitamin. Lower F2-IsoP concentrations were observed in ginseng users, whereas lower concentrations of 15-F2t-IsoP-M were shown in subjects who used a vitamin E supplement. Plasma concentrations of several antioxidants (ie, β-carotenes, both trans and cis β-carotenes, lycopene other than trans, 5-cis and 7-cis isomers, cis anhydrolutein, and cis β-cryptoxanthin) were inversely associated with 15-F2t-IsoP-M but not with F2-IsoPs, whereas β-, γ-, and δ-tocopherols were positively associated with 15-F2t-IsoP-M but not with F2-IsoPs. Urinary polyphenol quercetin was positively associated with both F2-IsoPs and 15-F2t-IsoP-M. Conclusion: The results suggest that the F2-IsoP major metabolite 15-F2t-IsoP-M may be a more sensitive marker of endogenous oxidative stress status than are F2-IsoPs in the assessment of effects of antioxidants on age-related diseases. PMID:22760572

Scale size and life time of energy conversion regions observed by Cluster in the plasma sheet

NASA Astrophysics Data System (ADS)

Hamrin, M.; Norqvist, P.; Marghitu, O.; Vaivads, A.; Klecker, B.; Kistler, L. M.; Dandouras, I.

2009-11-01

In this article, and in a companion paper by Hamrin et al. (2009) [Occurrence and location of concentrated load and generator regions observed by Cluster in the plasma sheet], we investigate localized energy conversion regions (ECRs) in Earth's plasma sheet. From more than 80 Cluster plasma sheet crossings (660 h data) at the altitude of about 15-20 RE in the summer and fall of 2001, we have identified 116 Concentrated Load Regions (CLRs) and 35 Concentrated Generator Regions (CGRs). By examining variations in the power density, E·J, where E is the electric field and J is the current density obtained by Cluster, we have estimated typical values of the scale size and life time of the CLRs and the CGRs. We find that a majority of the observed ECRs are rather stationary in space, but varying in time. Assuming that the ECRs are cylindrically shaped and equal in size, we conclude that the typical scale size of the ECRs is 2 RE≲ΔSECR≲5 RE. The ECRs hence occupy a significant portion of the mid altitude plasma sheet. Moreover, the CLRs appear to be somewhat larger than the CGRs. The life time of the ECRs are of the order of 1-10 min, consistent with the large scale magnetotail MHD simulations of Birn and Hesse (2005). The life time of the CGRs is somewhat shorter than for the CLRs. On time scales of 1-10 min, we believe that ECRs rise and vanish in significant regions of the plasma sheet, possibly oscillating between load and generator character. It is probable that at least some of the observed ECRs oscillate energy back and forth in the plasma sheet instead of channeling it to the ionosphere.

Effect of concentration variation on 2.0 µm emission of Ho3+-doped SiO2-Al2O3-Na2CO3-SrF2-CaF2 oxyfluorosilicate glasses

NASA Astrophysics Data System (ADS)

Gelija, Devarajulu; Borelli, Deva Prasad Raju

2018-02-01

The concentration variation of Ho3+ ion-doped SiO2-Al2O3-Na2CO3-SrF2-CaF2 glasses has been prepared by conventional melt quenching method. The thermal stability of 1 mol % of Ho3+-doped oxyfluorosilicate glass has been calculated using the differential thermal analysis (DTA) spectra. The phenomenological Judd-Ofelt intensity parameters Ωλ ( λ = 2, 4 and 6) were calculated for all concentrations of Ho3+ ions. The luminescence spectra in visible region of Ho3+ ion-doped glasses were recorded under the excitation wavelength of 452 nm. The spectra consists of several intense emission bands (5F4, 5S2) → 5I8 (547 nm), 5F3 → 5I8 (647 nm), 5F5 → 5I7 (660 nm) and (5F4, 5S2) → 5I7 (750 nm) in the range 500-780 nm. The fluorescence emission at ˜2.0 µm (5I7 → 5I8) was observed under the excitation of 488 nm Ar-ion laser. The stimulated emission cross section for 5I7 → 5I8 transition (˜2.0 µm) varies from 8.46 to 9.52 × 10-21 cm2, as calculated by the Fuchtbauer-Ladenburg (FL) theory. However, Mc-Cumber theory was used to calculate emission cross section values about 4.24-5.75 × 10-21 cm2 for the 5I7 → 5I8 transition in all concentrations of Ho3+-doped oxyfluorosilicate glasses. Therefore, these results reveal that the 0.5 mol % of Ho3+-doped oxyfluorosilicate glasses, exhibiting higher emission cross section, has potentially been used for laser applications at ˜ 2.0 µm.

Potential Electrostatic Interactions in Multiple Regions Affect Human Metapneumovirus F-Mediated Membrane Fusion

PubMed Central

Chang, Andres; Hackett, Brent A.; Winter, Christine C.; Buchholz, Ursula J.

2012-01-01

The recently identified human metapneumovirus (HMPV) is a worldwide respiratory virus affecting all age groups and causing pneumonia and bronchiolitis in severe cases. Despite its clinical significance, no specific antiviral agents have been approved for treatment of HMPV infection. Unlike the case for most paramyxoviruses, the fusion proteins (F) of a number of strains, including the clinical isolate CAN97-83, can be triggered by low pH. We recently reported that residue H435 in the HRB linker domain acts as a pH sensor for HMPV CAN97-83 F, likely through electrostatic repulsion forces between a protonated H435 and its surrounding basic residues, K295, R396, and K438, at low pH. Through site-directed mutagenesis, we demonstrated that a positive charge at position 435 is required but not sufficient for F-mediated membrane fusion. Arginine or lysine substitution at position 435 resulted in a hyperfusogenic F protein, while replacement with aspartate or glutamate abolished fusion activity. Studies with recombinant viruses carrying mutations in this region confirmed its importance. Furthermore, a second region within the F2 domain identified as being rich in charged residues was found to modulate fusion activity of HMPV F. Loss of charge at residues E51, D54, and E56 altered local folding and overall stability of the F protein, with dramatic consequences for fusion activity. As a whole, these studies implicate charged residues and potential electrostatic interactions in function, pH sensing, and overall stability of HMPV F. PMID:22761366

(18)F-FDG dynamic PET/CT in patients with multiple myeloma: patterns of tracer uptake and correlation with bone marrow plasma cell infiltration rate.

PubMed

Sachpekidis, Christos; Mai, Elias K; Goldschmidt, Hartmut; Hillengass, Jens; Hose, Dirk; Pan, Leyun; Haberkorn, Uwe; Dimitrakopoulou-Strauss, Antonia

2015-06-01

The value of F-FDG PET in the diagnostic approach of multiple myeloma (MM) remains incompletely elicited. Little is known about the kinetics of F-FDG in the bone marrow and extramedullary sites in MM. This study aimed to evaluate quantitative data on kinetics and distribution patterns of F-FDG in MM patients with regard to pelvic bone marrow plasma cell infiltration. The study included 40 patients with primary MM. Dynamic PET/CT scanning of the lower lumbar spine and pelvis was performed after the administration of F-FDG. Whole-body PET/CT studies were performed. Sites of focal increased tracer uptake were considered as highly suggestive of myelomatous involvement after taking into account the patient history and CT findings. Bone marrow of the os ilium without pathologic tracer accumulation served as reference. The evaluation of dynamic PET/CT studies was based in addition to the conventional visual (qualitative) assessment, on semiquantitative (SUV) calculations, as well as on absolute quantitative estimations after application of a 2-tissue compartment model and a noncompartmental approach. F-FDG quantitative information and corresponding distribution patterns were correlated with pelvic bone marrow plasma cell infiltration. Fifty-two myelomatous lesions were detected in the pelvis. All parameters in suspected MM lesions ranged in significantly higher levels than in reference tissue (P < 0.01). Correlative analyses revealed that bone marrow plasma cell infiltration rate correlated significantly with SUVaverage, SUVmax, and the parameters K1, influx, and fractal dimension of F-FDG in reference bone marrow (P < 0.01). In addition, whole-body static PET/CT imaging demonstrated 4 patterns of tracer uptake; these are as follows: negative, focal, diffuse, and mixed (focal/diffuse) tracer uptake. Patients with a mixed pattern of radiotracer uptake had the highest mean plasma cell infiltration rate in their bone marrow, whereas those with negative PET/CT scans

Ion Energy and Ion Flux Distributions of CF4/Ar/O2 Inductively Coupled Plasmas in a GEC Cell

NASA Technical Reports Server (NTRS)

Rao, M. V. V. S.; Cruden, Brett; Sharma, Surendra; Meyyappan, Meyya

2001-01-01

Knowledge of ion kinetics in plasma processing gas mixtures, such as CF4:Ar:O2, is important for understanding plasma assisted etching and deposition of materials. Ion energies and ion fluxes were measured in this mixture for 80:10:10, 60:20:20, and 40:30:30 mixture ratios in the pressure range of 10-50 mTorr, and at 200 and 300 W of RF power. Ions from plasma, sampled through a 10 micron orifice in the center of the lower plane electrode, were energy and mass analyzed by a combination of electrostatic energy and quadrupole mass filters. CFx(+) (x = 1 - 3), F2(+), F(+), C(+) from CF4, Ar(+) from Ar, and O2(+) and O(+) from O2, and by-product ions SiFx(+)(x = 1 - 3) from etching of quartz coupling window, COFx(+)(x = 1 - 3), CO(+), CO2(+), and OF(+) were detected. In all conditions ion flux decreases with increase of pressure but increase with increase of RF power. Ar(+) signal decreases with increase of pressure while CF3(+), which is the dominant ion at all conditions, increases with increase in pressure. The loss mechanism for Ar(+) and increase of CF3(+) is due to large cross section for Ar(+) + CF4 yields Ar + CF3(+) + F. Ion energies, which range from 15-25 eV depending on plasma operating conditions, are nearly Gaussian. By-product ion signals are higher at lower pressures indicating stronger plasma interaction with quartz window.

Calculation of thermodynamic properties and transport coefficients of C5F10O-CO2 thermal plasmas

NASA Astrophysics Data System (ADS)

Li, Xingwen; Guo, Xiaoxue; Murphy, Anthony B.; Zhao, Hu; Wu, Jian; Guo, Ze

2017-10-01

The thermodynamic properties and transport coefficients of C5F10O-CO2 gas mixtures, which are being considered as substitutes for SF6 in circuit breaker applications, are calculated for the temperature range from 300 K to 30 000 K and the pressure range from 0.05 MPa to 1.6 MPa. Special attention is paid on investigating the evolution of thermophysical properties of C5F10O-CO2 mixtures with different mixing ratios and with different pressures; both the mixing ratio and pressure significantly affect the properties. This is explained mainly in terms of the changes in the temperatures at which the dissociation and ionization reactions take place. Comparisons of different thermophysical properties of C5F10O-CO2 mixtures with those of SF6 are also carried out. It is found that most of the thermophysical properties of the C5F10O-CO2 mixtures, such as thermal conductivity, viscosity, and electrical conductivity, become closer to those of SF6 as the C5F10O concentration increases. The composition and thermophysical properties of pure C5F10O in the temperature range from 300 K to 2000 K based on the decomposition pathway are also given. The calculation results provide a basis for further study of the insulation and arc-quenching capability of C5F10O-CO2 gas mixtures as substitutes for SF6.

Thermodynamic assessment of the LiF-NaF-BeF2-ThF4-UF4 system

NASA Astrophysics Data System (ADS)

Capelli, E.; Beneš, O.; Konings, R. J. M.

2014-06-01

The present study describes the full thermodynamic assessment of the LiF-NaF-BeF2-ThF4-UF4 system which is one of the key systems considered for a molten salt reactor fuel. The work is an extension of the previously assessed LiF-NaF-ThF4-UF4 system with addition of BeF2 which is characterized by very low neutron capture cross section and a relatively low melting point. To extend the database the binary BeF2-ThF4 and BeF2-UF4 systems were optimized and the novel data were used for the thermodynamic assessment of BeF2 containing ternary systems for which experimental data exist in the literature. The obtained database is used to optimize the molten salt reactor fuel composition and to assess its properties with the emphasis on the melting behaviour.

Manganese Vanadate Chemistry in Hydrothermal BaF 2 Brines: Ba 3 Mn 2 (V 2 O 7 ) 2 F 2 and Ba 7 Mn 8 O 2 (VO 4 ) 2 F 23

DOE PAGES

Sanjeewa, Liurukara D.; McMillen, Colin D.; McGuire, Michael A.; ...

2016-12-05

We synthesized manganese vanadate fluorides using high-temperature hydrothermal techniques with BaF 2 as a mineralizer. Ba 3Mn 2(V 2O 7) 2F 2 crystallizes in space group C2/c and consists of dimers built from edge-sharing MnO 4F 2 trigonal prisms with linking V 2O 7 groups. Ba 7Mn 8O 2(VO 4) 2F 23 crystallizes in space group Cmmm, with a manganese oxyfluoride network built from edge- and corner-sharing Mn 2+/3+(O,F) 6 octahedra. The resulting octahedra form alternating Mn 2+ and Mn 2+/3+ layers separated by VO 4 tetrahedra. This latter compound exhibits a canted antiferromagnetic order below TN = 25 K.

RECONNECTION-DRIVEN DOUBLE LAYERS IN THE STRATIFIED PLASMA OF THE SOLAR TRANSITION REGION: SUPPLY OF HOT PLASMA INTO THE CORONA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Nagendra

A novel mechanism for the supply of hot plasma into the corona from the chromosphere is suggested here; the mechanism involves collisionless magnetic reconnection (CMR) in the transition region (TR) followed by double layer (DL) formation in the enhanced expansion of the chromospheric cold plasma mixed with CMR-heated hot electrons. It is well known that (i) the CMR produces energetic electrons and (ii) DLs naturally form in expanding dense plasmas containing a minor population of hot electrons. We apply these plasma physics facts to the dynamics of stratified plasma in the TR. In the TR where densities fall below ∼10{supmore » 16} m{sup −3}, all collisional mean-free paths, electron–ion, ion–neutral, and electron–neutral, become long enough to render plasma collisionless at kinetic scale lengths, making CMR and DL formation possible. The DLs accelerate the chromospheric cold ions to energies comparable to the energy of the hot electrons. When the upflowing energized ions neutralized by the escaping hot electrons thermalize, the resulting hot tenuous plasma supplies an energy flux ∼3 × 10{sup 5} erg cm{sup −2} s{sup −1} = 3 × 10{sup 2} J m{sup −2} s{sup −1} into the corona. The CMR–DL mechanism introduces sudden transitions in the TR as microstructures in both density and energy. The global transition in the TR could be a fractal structure containing such microscopic features. If not impossible, it is difficult to measure such microstructures, but it seems that the coronal heating begins in the nearly collisionless TR by CMR and DL formation.« less

M2-F2 cockpit instrument panels

NASA Image and Video Library

1966-03-27

This photo shows the right side cockpit instrumentation panel of the M2-F2 Lifting Body. The success of Dryden's M2-F1 program led to NASA's development and construction of two heavyweight lifting bodies based on studies at NASA's Ames and Langley research centers -- the M2-F2 and the HL-10, both built by the Northrop Corporation. The "M" refers to "manned" and "F" refers to "flight" version. "HL" comes from "horizontal landing" and 10 is for the tenth lifting body model to be investigated by Langley. The first flight of the M2-F2 -- which looked much like the "F1" -- was on July 12, 1966. Milt Thompson was the pilot. By then, the same B-52 used to air launch the famed X-15 rocket research aircraft was modified to also carry the lifting bodies. Thompson was dropped from the B-52's wing pylon mount at an altitude of 45,000 feet on that maiden glide flight. The M2-F2 weighed 4,620 pounds, was 22 feet long, and had a width of about 10 feet. On May 10, 1967, during the sixteenth glide flight leading up to powered flight, a landing accident severely damaged the vehicle and seriously injured the NASA pilot, Bruce Peterson. NASA pilots and researchers realized the M2-F2 had lateral control problems, even though it had a stability augmentation control system. When the M2-F2 was rebuilt at Dryden and redesignated the M2-F3, it was modified with an additional third vertical fin -- centered between the tip fins -- to improve control characteristics. The M2-F2/F3 was the first of the heavy-weight, entry-configuration lifting bodies. Its successful development as a research test vehicle answered many of the generic questions about these vehicles. NASA donated the M2-F3 vehicle to the Smithsonian Institute in December 1973. It is currently hanging in the Air and Space Museum along with the X-15 aircraft number 1, which was its hangar partner at Dryden from 1965 to 1969.

M2-F2 cockpit instrument panels

NASA Image and Video Library

1966-03-27

This photo shows the left side cockpit instrumentation panel of the M2-F2 Lifting Body. The success of Dryden's M2-F1 program led to NASA's development and construction of two heavyweight lifting bodies based on studies at NASA's Ames and Langley research centers -- the M2-F2 and the HL-10, both built by the Northrop Corporation. The "M" refers to "manned" and "F" refers to "flight" version. "HL" comes from "horizontal landing" and 10 is for the tenth lifting body model to be investigated by Langley. The first flight of the M2-F2 -- which looked much like the "F1" -- was on July 12, 1966. Milt Thompson was the pilot. By then, the same B-52 used to air launch the famed X-15 rocket research aircraft was modified to also carry the lifting bodies. Thompson was dropped from the B-52's wing pylon mount at an altitude of 45,000 feet on that maiden glide flight. The M2-F2 weighed 4,620 pounds, was 22 feet long, and had a width of about 10 feet. On May 10, 1967, during the sixteenth glide flight leading up to powered flight, a landing accident severely damaged the vehicle and seriously injured the NASA pilot, Bruce Peterson. NASA pilots and researchers realized the M2-F2 had lateral control problems, even though it had a stability augmentation control system. When the M2-F2 was rebuilt at Dryden and redesignated the M2-F3, it was modified with an additional third vertical fin -- centered between the tip fins -- to improve control characteristics. The M2-F2/F3 was the first of the heavy-weight, entry-configuration lifting bodies. Its successful development as a research test vehicle answered many of the generic questions about these vehicles. NASA donated the M2-F3 vehicle to the Smithsonian Institute in December 1973. It is currently hanging in the Air and Space Museum along with the X-15 aircraft number 1, which was its hangar partner at Dryden from 1965 to 1969.

Magnetic conjugate observation of the F3 layer using the SEALION ionosonde network

NASA Astrophysics Data System (ADS)

Uemoto, Jyunpei; Ono, Takayuki; Maruyama, Takashi; Saito, Susumu; Iizima, Masahide; Kumamoto, Atsushi

2007-01-01

Results from the meridional ionosonde network located in Southeast Asia (SEALION) demonstrate the interesting nature of the F 3 layer, showing its generation mechanism. Ionograms obtained on 16 November 2004 and 31 March 2005 at Chiang Mai (CMU; geographic latitude 18.8°N, geographic longitude 98.9°E, and magnetic latitude 13.2°N), Chumphon (CPN; 10.7°N, 99.4°E, and 3.2°N) and Kototabang (KTB; 0.2°S, 100.3°E, and 10.1°S) showed significant differences between CPN near the magnetic equator, and CMU and KTB in the magnetic low-latitude region. The simultaneous magnetic conjugate observations of the F 3 layer achieved using the SEALION ionosonde network data showed clear dependences of the F 3 layer on the magnetic latitude. It is suggested that these magnetic latitude dependences of the F 3 layer can be explained by considering the plasma diffusion effects along the magnetic field lines in the magnetic low-latitude region.

NaF-assisted combustion synthesis of MoSi2 nanoparticles and their densification behavior

NASA Astrophysics Data System (ADS)

Nersisyan, Hayk H.; Lee, Tae Hyuk; Ri, Vladislav; Lee, Jong Hyeon; Suh, Hoyoung; Kim, Jin-Gyu; Son, Hyeon Taek; Kim, Yong-Ho

2017-03-01

The exothermic reduction of oxides mixture (MoO3+2SiO2) by magnesium in NaF melt enables the synthesis of nanocrystalline MoSi2 powders in near-quantitative yields. The combustion wave with temperature of about 1000-1200 °C was recorded in highly diluted by NaF starting mixtures. The by-products of combustion reaction (NaF and MgO) were subsequently removed by leaching with acid and washing with water. The as-prepared MoSi2 nanopowder composed of spherical and dendritic shape particles was consolidated using the spark plasma sintering method at 1200-1500 °C and 50 MPa for 10 min. The result was dense compacts (98.6% theoretical density) possessing submicron grains and exhibiting hardness of 8.74-12.92 GPa.

Microcrystalline silicon thin films deposited by matrix-distributed electron cyclotron resonance plasma enhanced chemical vapor deposition using an SiF4 /H2 chemistry

NASA Astrophysics Data System (ADS)

Wang, Junkang; Bulkin, Pavel; Florea, Ileana; Maurice, Jean-Luc; Johnson, Erik

2016-07-01

For the growth of hydrogenated microcrystalline silicon (μc-Si:H) thin films by low temperature plasma-enhanced chemical vapor deposition (PECVD), silicon tetrafluoride (SiF4) has recently attracted interest as a precursor due to the resilient optoelectronic performance of the resulting material and devices. In this work, μc-Si:H films are deposited at high rates (7 Å s-1) from a SiF4 and hydrogen (H2) gas mixture by matrix-distributed electron cyclotron resonance PECVD (MDECR-PECVD). Increased substrate temperature and moderate ion bombardment energy (IBE) are demonstrated to be of vital importance to achieve high quality μc-Si:H films under such low process pressure and high plasma density conditions, presumably due to thermally-induced and ion-induced enhancement of surface species migration. Two well-defined IBE thresholds at 12 eV and 43 eV, corresponding respectively to SiF+ ion-induced surface and bulk atomic displacement, are found to be determinant to the final film properties, namely the surface roughness, feature size and crystalline content. Moreover, a study of the growth dynamics shows that the primary challenge to producing highly crystallized μc-Si:H films by MDECR-PECVD appears to be the nucleation step. By employing a two-step method to first prepare a highly crystallized seed layer, μc-Si:H films lacking any amorphous incubation layer have been obtained. A crystalline volume fraction of 68% is achieved with a substrate temperature as low as 120 °C, which is of great interest to broaden the process window for solar cell applications.

Heterogeneous processes in CF4/O2 plasmas probed using laser-induced fluorescence of CF2

NASA Astrophysics Data System (ADS)

Hansen, S. G.; Luckman, G.; Nieman, George C.; Colson, Steven D.

1990-09-01

Laser-induced fluorescence of CF2 is used to monitor heterogeneous processes in ≊300 mTorr CF4/O2 plasmas. CF2 is rapidly removed at fluorinated copper and silver surfaces in 13.56-MHz rf discharges as judged by a distinct dip in its spatial distribution. These metals, when employed as etch masks, are known to accelerate plasma etching of silicon, and the present results suggest catalytic dehalogenation of CF2 is involved in this process. In contrast, aluminum and silicon dioxide exhibit negligible reactivity with CF2, which suggests that aluminum masks will not appreciably accelerate silicon etching and that ground state CF2 does not efficiently etch silicon dioxide. Measurement of CF2 decay in a pulsed discharge coupled with direct laser sputtering of metal into the gas phase indicates the interaction between CF2 and the active metals is purely heterogeneous. Aluminum does, however, exhibit homogeneous reactivity with CF2. Redistribution of active metal by plasma sputtering readily occurs; silicon etch rates may also be enhanced by the metal's presence on the silicon surface. Polymers contribute CF2 to the plasma as they etch. The observation of an induction period suggests fluorination of the polymer surface is the first step in its degradation. Polymeric etch masks can therefore depress the silicon etch rate by removal of F atoms, the primary etchants.

Further study on the solar activity variation of daytime NmF2

NASA Astrophysics Data System (ADS)

Chen, Yiding; Liu, Libo

2010-12-01

The ionosonde observations in the East Asia-Australia sector are collected to further investigate the solar activity variation of daytime (0800 ˜ 1600 LT) NmF2. The linear increase rate of NmF2 with F10.7 at lower solar activity levels is remarkably dependent on latitude, season, and local time. The rate is largest in equinoxes (with an equinoctial asymmetry) and higher in the morning (afternoon) in local winter (summer) at geomagnetic midlatitudes; particularly, the maximum rates in local winter are obviously larger than those in local summer at northern midlatitudes. In the equatorial ionization anomaly (EIA) crest regions, the rates in equinoxes and December (June) solstice are remarkably higher than those in June (December) solstice at the northern (southern) EIA crest, and the rate grows from the morning sector to the afternoon sector. The variation trend of NmF2 with F10.7 also shows latitudinal, seasonal, and local time dependences. The saturation effect dominates in all seasons in the EIA regions; at midlatitudes, NmF2 nearly increases linearly with F10.7 in local winter so that a linear fit is a good approximation for NmF2 modeling, while the saturation effect still dominates in other seasons. The saturation effect is more significant in the afternoon, and the strongest saturation effect appears at the EIA crest latitudes in equinox afternoon. Discussions indicate that the variations of neutral atmosphere and hmF2 are responsible for the seasonal and local time dependences of the linear increase rate of NmF2 with F10.7 at midlatitudes, and the seasonal variation of neutral atmosphere is the primary reason for the seasonal dependence of the variation trend of NmF2 with F10.7, while dynamics processes are the more important factors controlling the linear increase rate and the variation trend of NmF2 with F10.7 at low latitudes. Furthermore, dynamics processes are important for the saturation effect, and the fountain effect is related to the strongest

The cathode plasma simulation

NASA Astrophysics Data System (ADS)

Suksila, Thada

Since its invention at the University of Stuttgart, Germany in the mid-1960, scientists have been trying to understand and explain the mechanism of the plasma interaction inside the magnetoplasmadynamics (MPD) thruster. Because this thruster creates a larger level of efficiency than combustion thrusters, this MPD thruster is the primary cadidate thruster for a long duration (planetary) spacecraft. However, the complexity of this thruster make it difficult to fully understand the plasma interaction in an MPD thruster while operating the device. That is, there is a great deal of physics involved: the fluid dynamics, the electromagnetics, the plasma dynamics, and the thermodynamics. All of these physics must be included when an MPD thruster operates. In recent years, a computer simulation helped scientists to simulate the experiments by programing the physics theories and comparing the simulation results with the experimental data. Many MPD thruster simulations have been conducted: E. Niewood et al.[5], C. K. J. Hulston et al.[6], K. D. Goodfellow[3], J Rossignol et al.[7]. All of these MPD computer simulations helped the scientists to see how quickly the system responds to the new design parameters. For this work, a 1D MPD thruster simulation was developed to find the voltage drop between the cathode and the plasma regions. Also, the properties such as thermal conductivity, electrical conductivity and heat capacity are temperature and pressure dependent. These two conductivity and heat capacity are usually definded as constant values in many other models. However, this 1D and 2D cylindrical symmetry MPD thruster simulations include both temperature and pressure effects to the electrical, thermal conductivities and heat capacity values interpolated from W. F. Ahtye [4]. Eventhough, the pressure effect is also significant; however, in this study the pressure at 66 Pa was set as a baseline. The 1D MPD thruster simulation includes the sheath region, which is the

Convection of Plasmaspheric Plasma into the Outer Magnetosphere and Boundary Layer Region: Initial Results

NASA Technical Reports Server (NTRS)

Ober, Daniel M.; Horwitz, J. L.

1998-01-01

We present initial results on the modeling of the circulation of plasmaspheric-origin plasma into the outer magnetosphere and low-latitude boundary layer (LLBL), using a dynamic global core plasma model (DGCPM). The DGCPM includes the influences of spatially and temporally varying convection and refilling processes to calculate the equatorial core plasma density distribution throughout the magnetosphere. We have developed an initial description of the electric and magnetic field structures in the outer magnetosphere region. The purpose of this paper is to examine both the losses of plasmaspheric-origin plasma into the magnetopause boundary layer and the convection of this plasma that remains trapped on closed magnetic field lines. For the LLBL electric and magnetic structures we have adopted here, the plasmaspheric plasma reaching the outer magnetosphere is diverted anti-sunward primarily along the dusk flank. These plasmas reach X= -15 R(sub E) in the LLBL approximately 3.2 hours after the initial enhancement of convection and continues to populate the LLBL for 12 hours as the convection electric field diminishes.

Effects of feedstock availability on the negative ion behavior in a C{sub 4}F{sub 8} inductively coupled plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Shu-Xia; Research group PLASMANT, Dept. Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp; Gao, Fei

2015-07-21

In this paper, the negative ion behavior in a C{sub 4}F{sub 8} inductively coupled plasma (ICP) is investigated using a hybrid model. The model predicts a non-monotonic variation of the total negative ion density with power at low pressure (10–30 mTorr), and this trend agrees well with experiments that were carried out in many fluorocarbon (fc) ICP sources, like C{sub 2}F{sub 6}, CHF{sub 3}, and C{sub 4}F{sub 8}. This behavior is explained by the availability of feedstock C{sub 4}F{sub 8} gas as a source of the negative ions, as well as by the presence of low energy electrons due tomore » vibrational excitation at low power. The maximum of the negative ion density shifts to low power values upon decreasing pressure, because of the more pronounced depletion of C{sub 4}F{sub 8} molecules, and at high pressure (∼50 mTorr), the anion density continuously increases with power, which is similar to fc CCP sources. Furthermore, the negative ion composition is identified in this paper. Our work demonstrates that for a clear understanding of the negative ion behavior in radio frequency C{sub 4}F{sub 8} plasma sources, one needs to take into account many factors, like the attachment characteristics, the anion composition, the spatial profiles, and the reactor configuration. Finally, a detailed comparison of our simulation results with experiments is conducted.« less

Regional differences in the lateral mobility of plasma membrane lipids in a molluscan embryo.

PubMed

Speksnijder, J E; Dohmen, M R; Tertoolen, L G; de Laat, S W

1985-07-01

Regional and temporal differences in plasma membrane lipid mobility have been analyzed during the first three cleavage cycles of the embryo of the polar-lobe-forming mollusc Nassarius reticulatus by the fluorescence photobleaching recovery (FPR) method, using 1,1'-ditetradecyl 3,3,3',3'-tetramethylindocarbocyanine iodide (C14diI) as a fluorescent lipid probe. During this period of development the lateral diffusion coefficient of membrane lipids is consistently greater in the vegetal polar lobe area as compared to the animal plasma membrane area (on average 30%), demonstrating the existence of an animal-vegetal polarity in plasma membrane properties. At third cleavage, the differences between animal and vegetal plasma membrane region become even more pronounced; in the four animal micromeres the diffusion coefficient (D) and mobile fraction (MF) are 2.9 +/- 0.2 X 10(-9) cm2/sec and 51 +/- 2%, respectively, while in the four vegetal macromeres D = 5.0 +/- 0.3 X 10(-9) cm2/sec and MF = 78 +/- 2%. Superimposed upon the observed animal-vegetal polarity, the lateral diffusion in the polar lobe membrane area shows a cell-cycle-dependent modulation. The highest mean values for D are reached during the S phase (ranging from 7.0 to 7.8 X 10(-9) cm2/sec in the three cycles measured), while at the end of G2 phase and during early mitosis mean values for D have decreased significantly (ranging from 5.0 to 5.9 X 10(-9) cm2/sec). Diffusion rates in the animal membranes of the embryo are constant during the three successive cell cycles (D = 4.3-5.0 X 10(-9) cm2/sec), except for a peak at the S phase of the first cell cycle (D = 6.0 X 10(-9) cm2/sec). These results are discussed in relation with previously observed ultrastructural heterogeneities in the Nassarius egg plasma membrane. It is speculated that the observed animal-vegetal polarity in the organization of the egg membrane might play an important role in the process of cell diversification during early development.

Regional Variability of Lifestyle Factors and Hypertension with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus: The Population-Based KORA-F4 and SHIP-TREND Studies in Germany.

PubMed

Stöckl, Doris; Rückert-Eheberg, Ina-Maria; Heier, Margit; Peters, Annette; Schipf, Sabine; Krabbe, Christine; Völzke, Henry; Tamayo, Teresa; Rathmann, Wolfgang; Meisinger, Christa

2016-01-01

Type 2 diabetes mellitus (T2D) shows regional differences in Germany. The purpose of the project was to compare the prevalence of prediabetes and undiagnosed T2D in two regions in Germany, the Northeast and the South, and to evaluate their associations with regional variations in lifestyle factors and hypertension. Data from the KORA-F4 study (South Germany, 2006-2008) and the SHIP-TREND study (Northeast Germany, 2008-2012) were used. Participants aged 35-79 years without T2D with an overnight fasting of more than 8 hours and an oral glucose tolerance test were included: KORA-F4: n = 2,616 and SHIP-TREND: n = 1,968. The prevalence of prediabetes/newly diagnosed T2D was especially high in men (about 60%) and women (about 50%) in the Northeast, followed by men (about 50%) and women (about 30%) in the South. Lifestyle factors associated with T2D varied between the regions: more participants in the Northeast were active smokers and the percentages of people with overweight or obesity were greater than in their southern counterparts. However, these differences could not explain the striking disparity in prediabetes/newly diagnosed T2D. The frequency of hypertension was also distinctly higher in the Northeast than in the South and clearly associated with prediabetes/newly diagnosed T2D. Especially in men living in the Northeast, screening individuals with blood pressure ≥ 140/90mmHg might reveal up to 70% of those with prediabetes/newly diagnosed T2D. Knowledge about regional variability in T2D and related risk factors is important for the planning of diabetes prevention programs. In our analyses, common lifestyle factors did not nearly explain these variations between the northern SHIP-TREND and the southern KORA-F4 studies. Further examinations of regional socioeconomic, political, environmental and other aspects are needed. Meanwhile, targeted diabetes prevention strategies with a special focus on men living in the northern parts of Germany are reasonable.

Regional Variability of Lifestyle Factors and Hypertension with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus: The Population-Based KORA-F4 and SHIP-TREND Studies in Germany

PubMed Central

Heier, Margit; Peters, Annette; Schipf, Sabine; Krabbe, Christine; Völzke, Henry; Tamayo, Teresa; Rathmann, Wolfgang; Meisinger, Christa

2016-01-01

Objective Type 2 diabetes mellitus (T2D) shows regional differences in Germany. The purpose of the project was to compare the prevalence of prediabetes and undiagnosed T2D in two regions in Germany, the Northeast and the South, and to evaluate their associations with regional variations in lifestyle factors and hypertension. Methods Data from the KORA-F4 study (South Germany, 2006–2008) and the SHIP-TREND study (Northeast Germany, 2008–2012) were used. Participants aged 35–79 years without T2D with an overnight fasting of more than 8 hours and an oral glucose tolerance test were included: KORA-F4: n = 2,616 and SHIP-TREND: n = 1,968. Results The prevalence of prediabetes/newly diagnosed T2D was especially high in men (about 60%) and women (about 50%) in the Northeast, followed by men (about 50%) and women (about 30%) in the South. Lifestyle factors associated with T2D varied between the regions: more participants in the Northeast were active smokers and the percentages of people with overweight or obesity were greater than in their southern counterparts. However, these differences could not explain the striking disparity in prediabetes/newly diagnosed T2D. The frequency of hypertension was also distinctly higher in the Northeast than in the South and clearly associated with prediabetes/newly diagnosed T2D. Especially in men living in the Northeast, screening individuals with blood pressure ≥ 140/90mmHg might reveal up to 70% of those with prediabetes/newly diagnosed T2D. Conclusions Knowledge about regional variability in T2D and related risk factors is important for the planning of diabetes prevention programs. In our analyses, common lifestyle factors did not nearly explain these variations between the northern SHIP-TREND and the southern KORA-F4 studies. Further examinations of regional socioeconomic, political, environmental and other aspects are needed. Meanwhile, targeted diabetes prevention strategies with a special focus on men living in the

Fine structure in plasma waves and radiation near the plasma frequency in Earth's foreshock

NASA Technical Reports Server (NTRS)

Cairns, Iver H.

1994-01-01

Novel observations are presented of intrunsic fine structure in the frequency spectrum of electomagnetic (EM) radiation and plasma waves near the electron plasma frequency f(sub p) during a period of unusually high interplanetary magnetic field strength. Measured using the wideband receiver on the International Sun-Earth Explorer (ISEE) 1 spacecraft, fine-structured emissions are observed both in the solar wind and the foreshock, The fine structure is shown to correspond to emissions spaced above f(sub p) near half harmonies of the electon cyclotron frequency f(sub ce), i.e., near f(sub p) + nf(sub ce)/2. These appear to be the first space physics observations of emissions spaced by f(sub ce)/2. Indirect but strong arguments are used to discriminate between EM and electrostatic (ES) signals, to identify whether ISEE 1 is in the solar wind or the foreshock, and to determine the relative frequencies of the emissions and the local f(sub p). The data are consistent with generation of the ES and EM emissions in the foreshock, with subsequent propagation of the EM emissions into the solar wind. It remains possible that some emissions currently identified as ES have significant EM character. The ES and EM emisions often merge into one another with minimal changes in frequency, arguing that their source regions and generation mechanisms are related and imposing significant constraints on theories. The f(sub ce)/2 ES and EM fine structures observed may be intrinsic to the emission mechanisms or to superposition of two series of signals with f(sub ce) spacing that differ in starting frequency by f(sub ce)/2. Present theories for nonlinear wave coupling processes, cyclotron maser emission, and other linear instability processes are all unable to explain multiple EM and/or ES components spaced by approximately f(sub ce)/2 above f(sub p) for f(sub p)/f(sub ce) much greater than 1 and typical for shock beams parameters. Suitable avenues for further theoretical research are

First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine.

PubMed

Sabri, Osama; Becker, Georg-Alexander; Meyer, Philipp M; Hesse, Swen; Wilke, Stephan; Graef, Susanne; Patt, Marianne; Luthardt, Julia; Wagenknecht, Gudrun; Hoepping, Alexander; Smits, René; Franke, Annegret; Sattler, Bernhard; Habermann, Bernd; Neuhaus, Petra; Fischer, Steffen; Tiepolt, Solveig; Deuther-Conrad, Winnie; Barthel, Henryk; Schönknecht, Peter; Brust, Peter

2015-09-01

α4β2* nicotinic receptors (α4β2* nAChRs) could provide a biomarker in neuropsychiatric disorders (e.g., Alzheimer's and Parkinson's diseases, depressive disorders, and nicotine addiction). However, there is a lack of α4β2* nAChR specific PET radioligands with kinetics fast enough to enable quantification of nAChR within a reasonable time frame. Following on from promising preclinical results, the aim of the present study was to evaluate for the first time in humans the novel PET radioligand (-)-[(18)F]Flubatine, formerly known as (-)-[(18)F]NCFHEB, as a tool for α4β2* nAChR imaging and in vivo quantification. Dynamic PET emission recordings lasting 270min were acquired on an ECAT EXACT HR+ scanner in 12 healthy male non-smoking subjects (71.0±5.0years) following the intravenous injection of 353.7±9.4MBq of (-)-[(18)F]Flubatine. Individual magnetic resonance imaging (MRI) was performed for co-registration. PET frames were motion-corrected, before the kinetics in 29 brain regions were characterized using 1- and 2-tissue compartment models (1TCM, 2TCM). Given the low amounts of metabolite present in plasma, we tested arterial input functions with and without metabolite corrections. In addition, pixel-based graphical analysis (Logan plot) was used. The model's goodness of fit, with and without metabolite correction was assessed by Akaike's information criterion. Model parameters of interest were the total distribution volume VT (mL/cm(3)), and the binding potential BPND relative to the corpus callosum, which served as a reference region. The tracer proved to have high stability in vivo, with 90% of the plasma radioactivity remaining as untransformed parent compound at 90min, fast brain kinetics with rapid uptake and equilibration between free and receptor-bound tracer. Adequate fits of brain TACs were obtained with the 1TCM. VT could be reliably estimated within 90min for all regions investigated, and within 30min for low-binding regions such as the cerebral

NiF2/NaF:CaF2/Ca Solid-State High-Temperature Battery Cells

NASA Technical Reports Server (NTRS)

West, William; Whitacre, Jay; DelCastillo, Linda

2009-01-01

Experiments and theoretical study have demonstrated the promise of all-solid-state, high-temperature electrochemical battery cells based on NiF2 as the active cathode material, CaF2 doped with NaF as the electrolyte material, and Ca as the active anode material. These and other all-solid-state cells have been investigated in a continuing effort to develop batteries for instruments that must operate in environments much hotter than can be withstood by ordinary commercially available batteries. Batteries of this type are needed for exploration of Venus (where the mean surface temperature is about 450 C), and could be used on Earth for such applications as measuring physical and chemical conditions in geothermal wells and oil wells. All-solid-state high-temperature power cells are sought as alternatives to other high-temperature power cells based, variously, on molten anodes and cathodes or molten eutectic salt electrolytes. Among the all-solid-state predecessors of the present NiF2/NaF:CaF2/Ca cells are those described in "Solid-State High-Temperature Power Cells" (NPO-44396), NASA Tech Briefs, Vol. 32, No. 5 (May 2008), page 40. In those cells, the active cathode material is FeS2, the electrolyte material is a crystalline solid solution of equimolar amounts of Li3PO4 and LiSiO4, and the active anode material is Li contained within an alloy that remains solid in the intended high operational temperature range.

Feature Profile Evolution of SiO2 Trenches In Fluorocarbon Plasmas

NASA Technical Reports Server (NTRS)

Hwang, Helen; Govindan, T. R.; Meyyappan, M.; Arunachalam, Valli; Rauf, Shahid; Coronell, Dan; Carroll, Carol W. (Technical Monitor)

1999-01-01

Etching of silicon microstructures for semiconductor manufacturing in chlorine plasmas has been well characterized. The etching proceeds in a two-part process, where the chlorine neutrals passivate the Si surface and then the ions etch away SiClx. However, etching in more complicated gas mixtures and materials, such as etching of SiO2 in Ar/C4F8, requires knowledge of the ion and neutral distribution functions as a function of angle and velocity, in addition to modeling the gas surface reactions. In order to address these needs, we have developed and integrated a suite of models to simulate the etching process from the plasma reactor level to the feature profile evolution level. This arrangement allows for a better understanding, control, and prediction of the influence of equipment level process parameters on feature profile evolution. We are currently using the HPEM (Hybrid Plasma Equipment Model) and PCMCM (Plasma Chemistry Monte Carlo Model) to generate plasma properties and ion and neutral distribution functions for argon/fluorocarbon discharges in a GEC Reference Cell. These quantities are then input to the feature scale model, Simulation of Profile Evolution by Level Sets (SPELS). A surface chemistry model is used to determine the interaction of the incoming species with the substrate material and simulate the evolution of the trench profile. The impact of change of gas pressure and inductive power on the relative flux of CFx and F to the wafer, the etch and polymerization rates, and feature profiles will be examined. Comparisons to experimental profiles will also be presented.

Simultaneous prenoon and postnoon observations of three field-aligned current systems from Viking and DMSP-F7

NASA Technical Reports Server (NTRS)

Ohtani, S.; Potemra, T. A.; Newell, P. T.; Zanetti, L. J.; Iijima, T.; Watanabe, M.; Yamauchi, M.; Elphinstone, R. D.; De La Beauijardie, O.; Blomberg, L. G.

1995-01-01

The spatial structure of dayside large-scale field-aligned current (FAC) systems is examined by using Viking and Defense Meteorological Satellite Program-F7 (DMSP-F7) data. We focus on four events in which the satellites simultaneously observed postnoon and prenoon three FAC systems: the region 2, the region 1, and the mantle (referred to as midday region O) systems, from equatorward to poleward. These events provide the most solid evidence to date that the midday region O system is a separate and unique FAC system, and is not an extension of the region 1 system from other local times. The events are examined comprehensively by making use of a mulit-instrumental data set, which includes magnetic field, particle flux, electric field, auroral UV image data from the satellites, and the Sondrestrom convection data. The results are summarized as follows: (1) Region 2 currents flow mostly in the central plasma sheet (CPS) precipitation region, often overlapping with the boundary plasma sheet (BPD) at their poleward edge. (2) The region 1 system is located in the core part of the auroral oval and is confined in a relatively narrow range in latitude which includes the convection reversal. The low-latitude boundary layer, possibly including the outer part of the plasma sheet, and the external cusp are the major source regions of dayside region 1 currents. (2) Midday region O currents flow on open field lines and are collocated with the shear of antisunward convection flows with velocites decreasing poleward. On the basis of these results we support the view that both prenoon and postnoon current systems consist of the three-sheet structure when the disctortion ofthe convection pattern associated with interplanetary magnetic field (IMF) B(sub Y) is small and both morningside and eveningside convection cells are crescent-shaped. We also propose that the midday region O and a part of the region 1 systems are closely coupled to the same source.

Spectrophotometer properties of vein blood plasma in UF-region patients with sharp surgical pathology of abdominal region organs

NASA Astrophysics Data System (ADS)

Guminestskij, S. G.; Polianski, I. J.; Motrich, A. V.; Grunchuk, F. W.

2006-05-01

It is set that there are two maximums in UF- region absorption of vein blood plasma of a man: at λ = 235 nm and at λ = 280 nm. It is shown that there are the substantial changes of values of the optical density D comparative with controls (for donors) exactly in a maximum at development of sharp surgical diseases of organs of abdominal region λ = 280 nm, in that time as maximum at λ = 235 nm in this plan is not informing. Resulted results of researches of dynamics of changes of optical properties of vein blood plasma in UF- region of patients with pathology of abdominal region organs in after operating period (sharp appendicitis, sharp pancreatitis, intestinal impassability and others like that), which can have the diagnostic value.

Three-dimensional reduced-graphene/MnO2 prepared by plasma treatment as high-performance supercapacitor electrodes

NASA Astrophysics Data System (ADS)

Liu, Runru; Wen, Dongdong; Zhang, Xueyu; Wang, Dejun; Yang, Qiang; Yuan, Beilei; Lü, Wei

2018-06-01

In this work, three-Dimensional nitrogen-doped graphene/MnO2 (NG/MnO2) was prepared by plasma treatment, which provides a high specific surface area due to porous structure and exhibits enhanced supercapacitor performance. The advantage of NG/MnO2 electrode was obvious compared with reduced graphene oxide/MnO2 (RGO/MnO2) which was prepared by traditional hydrothermal method, such as improved electrochemical property and better cycling stability. The specific capacitance of NG/MnO2 at the scan rate of 5 mV s‑1 (393 F g‑1) is higher than that of RGO/MnO2 (260 F g‑1). In addition, NG/MnO2 showed higher durability with 90.2% capacitance retention than that of RGO/MnO2 (82%) after 5000 cycles. Such cheap and high-performance supercapacitor electrodes are available by our feasible plasma treatment, which give promise in large-scale commercial energy storage devices.

Infrared spectra of MF2, MF2+, MF4-, MF3, and M2F6 molecules (M = Sc, Y, La) in solid argon.

PubMed

Wang, Xuefeng; Andrews, Lester

2010-02-18

Reactions of laser-ablated Sc, Y and La atoms with F(2) in excess argon gave new absorptions in the M-F stretching region, which are assigned to metal fluoride neutral species MF(2) and MF(3) and ions MF(2)(+) and MF(4)(-). Dibridged MF(3) dimers, M(2)F(6), were also identified through terminal M-F and bridge M-F-M stretching modes. Density functional theory (DFT) calculations substantiated the experimental assignments. Mulliken and natural charge distributions indicate significant electron transfer from metal d orbitals to F ligands that increase from Sc to La, suggesting that strong participation of La 5d orbital hybridization drives the F-La-F bond angle below 120 degrees.

"Hot" Non-flaring Plasmas in Active Region Cores Heated by Single Nanoflares

NASA Astrophysics Data System (ADS)

Barnes, Will Thomas; Cargill, Peter; Bradshaw, Stephen

2016-05-01

We use hydrodynamic modeling tools, including a two-fluid development of the EBTEL code, to investigate the properties expected of "hot" (i.e. between 106.7 and 107.2 K) non-flaring plasmas due to nanoflare heating in active regions. Here we focus on single nanoflares and show that while simple models predict an emission measure distribution extending well above 10 MK that is consistent with cooling by thermal conduction, many other effects are likely to limit the existence and detectability of such plasmas. These include: differential heating between electrons and ions, ionization non-equilibrium and, for short nanoflares, the time taken for the coronal density to increase. The most useful temperature range to look for this plasma, often called the "smoking gun" of nanoflare heating, lies between 1 MK and 10 MK. Signatures of the actual heating may be detectable in some instances.

Theoretical study of the ionospheric plasma cave in the equatorial ionization anomaly region

NASA Astrophysics Data System (ADS)

Chen, Yu-Tsung; Lin, C. H.; Chen, C. H.; Liu, J. Y.; Huba, J. D.; Chang, L. C.; Liu, H.-L.; Lin, J. T.; Rajesh, P. K.

2014-12-01

This paper investigates the physical mechanism of an unusual equatorial electron density structure, plasma cave, located underneath the equatorial ionization anomaly by using theoretical simulations. The simulation results provide important new understanding of the dynamics of the equatorial ionosphere. It has been suggested previously that unusual E>⇀×B>⇀ drifts might be responsible for the observed plasma cave structure, but model simulations in this paper suggest that the more likely cause is latitudinal meridional neutral wind variations. The neutral winds are featured by two divergent wind regions at off-equator latitudes and a convergent wind region around the magnetic equator, resulting in plasma divergences and convergence, respectively, to form the plasma caves structure. The tidal-decomposition analysis further suggests that the cave related meridional neutral winds and the intensity of plasma cave are highly associated with the migrating terdiurnal tidal component of the neutral winds.

Heavily doped n-type a-IGZO by F plasma treatment and its thermal stability up to 600 °C

NASA Astrophysics Data System (ADS)

Um, Jae Gwang; Jang, Jin

2018-04-01

We report the electrical properties and thermal stability of heavily doped, amorphous indium-gallium-zinc-oxide (a-IGZO) treated with fluorine (F) plasma. When the F doping concentration in a-IGZO is 17.51 × 1021/cm-3, the a-IGZO exhibits a carrier concentration of 6 × 1019 cm-3, a resistivity of 3 × 10-3 Ω cm, and a Hall mobility of 20 cm2/V s. This indicates that F is a suitable n-type dopant in a-IGZO. The similarity of the ionic radius of F to that of oxygen (O) allows substitutional doping by replacing O with F or the occupation of the oxygen vacancy (VO) site by F and consequent reduction in defect density. The semiconducting property of a-IGZO can change into metallic behavior by F doping. The defect passivation by F incorporation is confirmed by the XPS depth profile, which reveals the significant reduction in the VO concentration due to the formation of In-F bonds. The heavily doped a-IGZO exhibits thermally stable conductivity up to 600 °C annealing and thus can be widely used for the ohmic contact of a-IGZO devices.

Constraining hot plasma in a non-flaring solar active region with FOXSI hard X-ray observations

NASA Astrophysics Data System (ADS)

Ishikawa, Shin-nosuke; Glesener, Lindsay; Christe, Steven; Ishibashi, Kazunori; Brooks, David H.; Williams, David R.; Shimojo, Masumi; Sako, Nobuharu; Krucker, Säm

2014-12-01

We present new constraints on the high-temperature emission measure of a non-flaring solar active region using observations from the recently flown Focusing Optics X-ray Solar Imager (FOXSI) sounding rocket payload. FOXSI has performed the first focused hard X-ray (HXR) observation of the Sun in its first successful flight on 2012 November 2. Focusing optics, combined with small strip detectors, enable high-sensitivity observations with respect to previous indirect imagers. This capability, along with the sensitivity of the HXR regime to high-temperature emission, offers the potential to better characterize high-temperature plasma in the corona as predicted by nanoflare heating models. We present a joint analysis of the differential emission measure (DEM) of active region 11602 using coordinated observations by FOXSI, Hinode/XRT, and Hinode/EIS. The Hinode-derived DEM predicts significant emission measure between 1 MK and 3 MK, with a peak in the DEM predicted at 2.0-2.5 MK. The combined XRT and EIS DEM also shows emission from a smaller population of plasma above 8 MK. This is contradicted by FOXSI observations that significantly constrain emission above 8 MK. This suggests that the Hinode DEM analysis has larger uncertainties at higher temperatures and that > 8 MK plasma above an emission measure of 3 × 1044 cm-3 is excluded in this active region.

Initial Results of the Spread F Experiment (SpreadFEx): Overview and Evidence of Possible Gravity Wave Excitation of Equatorial Plasma Bubbles

NASA Astrophysics Data System (ADS)

Fritts, D. C.

2007-05-01

The Spread F Experiment (SpreadFEx) was performed in Brazil by Brazilian and U.S. researchers during two ~20- day periods extending from September to November 2005. We employed extensive ground-based and space- based observations of gravity waves, plasma structures, electron densities, and mean atmospheric and ionospheric conditions using airglow, digisonde, VHF and meteor radar, balloon, GPS and satellite instrumentation at multiple sites in Brazil and with GUVI aboard the TIMED satellite. These measurements focused on deep convection, gravity waves, and plasma bubble structures. This comprehensive data set has provided the first promising indications of the specific roles of gravity waves arising from deep convection and other sources in contributing to the seeding of equatorial spread F and plasma bubbles extending to high altitudes. This talk will summarize the campaign results related to possible neutral atmosphere seeding of spread F and plasma bubbles during these observations. Specifically, our measurements have revealed significant neutral density (and related wind and temperature) perturbations extending from ~80 km well into the thermosphere and ionosphere. Many of these appear to arise from deep convection over the Amazon basin. Others occurring at larger scales under magnetically-disturbed conditions may have auroral or other higher-latitude sources. Both appear to lead, on occasion, to sufficiently large perturbations of the bottomside F layer to trigger plasma bubbles extending to much higher altitudes thereafter. Upon completion of our analyses, we believe that these observations will yield the first persuasive evidence of the role of neutral atmosphere gravity waves in the seeding of equatorial plasma bubbles.

Fluoride ion donor properties of cis-OsO(2)F(4): synthesis, raman spectroscopic study, and X-ray crystal structure of [OsO(2)F(3)][Sb(2)F(11)].

PubMed

Hughes, Michael J; Mercier, Hélène P A; Schrobilgen, Gary J

2010-01-04

The salt, [OsO(2)F(3)][Sb(2)F(11)], has been synthesized by dissolution of cis-OsO(2)F(4) in liquid SbF(5), followed by removal of excess SbF(5) at 0 degrees C to yield orange, crystalline [OsO(2)F(3)][Sb(2)F(11)]. The X-ray crystal structure (-173 degrees C) consists of an OsO(2)F(3)(+) cation fluorine bridged to an Sb(2)F(11)(-) anion. The light atoms of OsO(2)F(3)(+) and the bridging fluorine atom form a distorted octahedron around osmium in which the osmium atom is displaced from its center toward an oxygen atom and away from the trans-fluorine bridge atom. As in other transition metal dioxofluorides, the oxygen ligands are cis to one another and the fluorine bridge atom is trans to an oxygen ligand and cis to the remaining oxygen ligand. The Raman spectrum (-150 degrees C) of solid [OsO(2)F(3)][Sb(2)F(11)] was assigned on the basis of the ion pair observed in the low-temperature crystal structure. Under dynamic vacuum, [OsO(2)F(3)][Sb(2)F(11)] loses SbF(5), yielding the known [mu-F(OsO(2)F(3))(2)][Sb(2)F(11)] salt with no evidence for [OsO(2)F(3)][SbF(6)] formation. Attempts to synthesize [OsO(2)F(3)][SbF(6)] by the reaction of [OsO(2)F(3)][Sb(2)F(11)] with an equimolar amount of cis-OsO(2)F(4) or by a 1:1 stoichiometric reaction of cis-OsO(2)F(4) with SbF(5) in anhydrous HF yielded only [mu-F(OsO(2)F(3))(2)][Sb(2)F(11)]. Quantum-chemical calculations at the SVWN and B3LYP levels of theory and natural bond orbital analyses were used to calculate the gas-phase geometries, vibrational frequencies, natural population analysis charges, bond orders, and valencies of OsO(2)F(3)(+), [OsO(2)F(3)][Sb(2)F(11)], [OsO(2)F(3)][SbF(6)], and Sb(2)F(11)(-). The relative thermochemical stabilities of [OsO(2)F(3)][SbF(6)], [OsO(2)F(3)][Sb(2)F(11)], [OsO(2)F(3)][AsF(6)], [mu-F(OsO(2)F(3))(2)][SbF(6)], [mu-F(OsO(2)F(3))(2)][Sb(2)F(11)], and [mu-F(OsO(2)F(3))(2)][AsF(6)] were assessed using the appropriate Born-Haber cycles to account for the preference for [mu-F(OsO(2)F(3))(2

Time-Varying Seismogenic Coulomb Electric Fields as a Probable Source for Pre-Earthquake Variation in the Ionospheric F2-Layer

NASA Astrophysics Data System (ADS)

Kim, Vitaly P.; Hegai, Valery V.; Liu, Jann Yenq; Ryu, Kwangsun; Chung, Jong-Kyun

2017-12-01

The electric coupling between the lithosphere and the ionosphere is examined. The electric field is considered as a time- varying irregular vertical Coulomb field presumably produced on the Earth’s surface before an earthquake within its epicentral zone by some micro-processes in the lithosphere. It is shown that the Fourier component of this electric field with a frequency of 500 Hz and a horizontal scale-size of 100 km produces in the nighttime ionosphere of high and middle latitudes a transverse electric field with a magnitude of 20 mV/m if the peak value of the amplitude of this Fourier component is just 30 V/m. The time-varying vertical Coulomb field with a frequency of 500 Hz penetrates from the ground into the ionosphere by a factor of 7×105 more efficient than a time independent vertical electrostatic field of the same scale size. The transverse electric field with amplitude of 20 mV/m will cause perturbations in the nighttime F region electron density through heating the F region plasma resulting in a reduction of the downward plasma flux from the protonosphere and an excitation of acoustic gravity waves.

Divalent europium doped CaF 2 and BaF 2 nanocrystals from ionic liquids

DOE PAGES

Anghel, Sergiu; Golbert, Sebastian; Meijerink, Andries; ...

2016-10-11

A new, facile and quick synthesis method for Eu 2+ doped the alkaline earth fluorides was developed using ionic liquids as solvent, precursor and capping agent. Reductive atmosphere and very high temperatures were avoided, while still attaining the desired structure, small particle sizes and divalent oxidation state of the lanthanide. Here, this opens the door for the development of new Ln 2+ doped nanomaterials. Here, the successful Eu 2+ incorporation was proven by optical spectroscopic measurements which showed the spin and parity allowed f-d transitions of Eu 2+ in CaF 2:Eu 2+/BaF 2:Eu 2+. 4f 7-4f 7 transitions could bemore » observed at low temperatures (7 K).« less

Magnetosheath-ionspheric plasma interactions in the cusp/cleft. 2: Mesoscale particle simulations

NASA Technical Reports Server (NTRS)

Winglee, R. M.; Menietti, J. D.; Lin, C. S.

1993-01-01

Ionospheric plasma flowing out from the cusp can be an important source of plasma to the magnetosphere. One source of free energy that can drive this outflow is the injection of magnetosheath plasma into the cusp. Two-dimensional (three velocity) mesoscale particle simulations are used to investigate the particle dynamics in the cusp during southward interplanetary magnetic field. This mesoscale model self-consistently incorporates (1) global influences such as the convection of plasma across the cusp, the action of the mirror force, and the injection of the magnetosheath plasma, and (2) wave-particle interactions which produce the actual coupling between the magnetosheath and ionospheric plasmas. It is shown that, because the thermal speed of the electrons is higher than the bulk motion of the magnetosheath plasma, an upward current is formed on the equatorward edge of the injection region with return currents on either side. However, the poleward return currents are the stronger due to the convection and mirroring of many of the magnetosheath electrons. The electron distribution in this latter region evolves from upward directed streams to single-sided loss cones or possibly electron conics. The ion distribution also shows a variety of distinct features that are produced by spatial and/or temporal effects associated with varying convection patterns and wave-particle interactions. On the equatorward edge the distribution has a downflowing magnetosheath component and an upflowing cold ionospheric component due to continuous convection of ionospheric plasma into the region. In the center of the magnetosheath region, heating from the development of an ion-ion streaming instability causes the suppression of the cold ionospheric component and the formation of downward ionospheric streams. Further poleward there is velocity filtering of ions with low pitch angles, so that the magnetosheath ions develop a ring-beam distribution and the ensuing wave instabilities generate

Optical properties of Ni2+ and radiation defects in MgF sub 2 and MnF sub 2

NASA Astrophysics Data System (ADS)

Feuerhelm, L. N.

1980-03-01

The radiation defects in pure MgF2 were made by observating the polarized absorption, luminescence, and excitation spectra in electron-irradiated MgF2. Additionally, studies of the absorption, emission, excitation, and temperature dependence of the lifetimes of transitions in nickel-doped MgF2 and MnF2 were accomplished, as well as the observation of radiation effects on these crystals. The absorption band at about 320 nm in irradiated MgF2 is identified to be due to the F2(D2b) center, and to have an emission at about 450 nm. Analysis of the temperature dependence of this band indicates a dominant phonon mode of 255 cm(-1) for the excited state. The F2(C1) center is identified with an absorption of about 360 nm and an emission of 410 nm. An absorption peak at 300 nm, for which no corresponding emission was found, is tentatively identified to be the F3-center, and to have a dominant phonon mode of 255 cm(-1). The temperature dependence of the lifetimes of transitions in nickel-doped MgF2 is analyzed by the quantum mechanical single configuration coordinate model of Struck and Fonger, and a complete configuration coordinate model is made for this crystal. Similar studies are made in MnF2:Ni.

Investigations of electron attachment to the perfluorocarbon molecules c-C4F8, 2-C4F8, 1,3 C4F6, and c-C5F8

NASA Astrophysics Data System (ADS)

Feil, Stefan; Märk, Tilmann D.; Mauracher, Andreas; Scheier, Paul; Mayhew, Chris A.

2008-11-01

Non-dissociative and dissociative electron attachment to a series of gas-phase perfluorocarbons (PFCs), namely octafluorocyclobutane, c-C4F8, octafluorobut-2-ene (perfluoro-2-butene), 2-C4F8, hexafluorobuta-1,3-diene (1,3 perfluorobutadiene), 1,3 C4F6, and octafluorocyclopentene (perfluorocyclopentene), c-C5F8, of importance to technological plasmas, have been investigated using two different, but complimentary, instruments available in Innsbruck over the electron energy range 0-20 eV. Anion yields as a function of electron energy have been recorded, with the positions and intensities of the electron attachment resonances being determined. One of these instruments is a double focusing sector field mass spectrometer (VG-ZAB-2SEQ), which has been used for measurements requiring high sensitivity and for obtaining accurate relative anion yields. It has also been used to determine the electron detachment lifetimes of the parent anions under various accelerating voltages, and these results are also presented. The second instrument (CELIA) is a trochoidal electron monochromator coupled to a quadrupole mass filter with a pulse counting system for detecting product anionic species. This provides a much higher energy resolution than the VG-ZAB, which makes it a better instrument to investigate narrow energy resonances close to 0 eV. The results of anion yields, peak positions and the relative intensities presented in this paper are compared with previous data of electron attachment to the above PFCs, including investigations by Professor Eugen Illenberger.

Cluster size resolving analysis of CH3F-(ortho-H2)n in solid para-hydrogen using FTIR absorption spectroscopy at 3 μm region.

PubMed

Miyamoto, Yuki; Momose, Takamasa; Kanamori, Hideto

2012-11-21

Infrared absorption spectra of methyl fluoride with ortho-hydrogen (ortho-H(2)) clusters in a solid para-hydrogen (para-H(2)) crystal at 3.6 K were studied in the C-H stretching fundamental region (~3000 cm(-1)) using an FTIR spectrometer. As shown previously, the ν(3) C-F stretching fundamental band of CH(3)F-(ortho-H(2))(n) (n = 0, 1, 2, ...) clusters at 1040 cm(-1) shows a series of n discrete absorption lines, which correspond to different-sized clusters. We observed three unresolved broad peaks in the C-H stretching region and applied this cluster model to them assuming the same intensity distribution function as the ν(3) band. A fitting analysis successfully gave us the linewidth and lineshift of the components in each vibrational band. It was found that the separately determined linewidth, matrix shift of the band origin, and cluster shift are dependent on the vibrational mode. From the transition intensities of the monomer component derived from the fitting analysis, we discuss the mixing ratio of the vibrational modes due to Fermi resonance.

Equatorial F region neutral winds and shears near sunset measured with chemical release techniques

NASA Astrophysics Data System (ADS)

Kiene, A.; Larsen, M. F.; Kudeki, E.

2015-10-01

The period near sunset is a dynamic and critical time for the daily development of the equatorial nighttime ionosphere and the instabilities that occur there. It is during these hours that the preconditions necessary for the later development of Equatorial Spread F (ESF) plasma instabilities occur. The neutral dynamics of the sunset ionosphere are also of critical importance to the generation of currents and electric fields; however, the behavior of the neutrals is experimentally understood primarily through very limited single-altitude measurements or measurements that provide weighted altitude means of the winds as a function of time. To date, there have been very few vertically resolved neutral wind measurements in the F region at sunset. We present two sets of sounding rocket chemical release measurements, one from a launch in the Marshall Islands on Kwajalein atoll and one from Alcantara, Brazil. Analysis of the release motions has yielded vertically resolved neutral wind profiles that show both the mean horizontal winds and the vertical shears in the winds. In both experiments, we observe significant vertical gradients in the zonal wind that are unexpected by classical assumptions about the behavior of the neutral wind at these altitudes at sunset near the geomagnetic equator.

Infrared absorption spectra of N(CxF2x+1)3, x = 2-5 perfluoroamines

NASA Astrophysics Data System (ADS)

Bernard, François; Papanastasiou, Dimitrios K.; Papadimitriou, Vassileios C.; Burkholder, James B.

2018-05-01

Infrared absorption spectra of the perfluoroamines (N(C2F5)3, N(C3F7)3, N(C4F9)3, and N(C5F11)3) were measured over the 500-4000 cm-1 spectral region at 294 K using Fourier transform infrared (FTIR) spectroscopy at 1 cm-1 resolution. Spectral measurements were performed using static measurements of dilute perfluoroamines mixtures and by infusion of the pure compound into a calibrated gas flow. The perfluoroamines absorb strongly in the "atmospheric window" with integrated band strengths (10-17 cm2 molecule-1 cm-1) between 570 and 1500 cm-1 of 59.9, 74.9, 88.9, and 98.7 for N(C2F5)3, N(C3F7)3, N(C4F9)3, and N(C5F11)3, respectively. Radiative efficiencies (RE) for the perfluoroamines were estimated to be 0.61, 0.75, 0.87, and 0.95 W m-2 ppb-1 for atmospherically well-mixed conditions and including a +10% stratospheric temperature correction for N(C2F5)3, N(C3F7)3, N(C4F9)3, and N(C5F11)3, respectively. Theoretical calculations of the perfluoroamines were performed at the B97-1/6-311++G(2df,2p) level of theory and optimized perfluoroamine geometries, vibrational band positions, and band strengths are reported. The theoretically calculated infrared spectra are in good agreement with the experimental spectra, while comparison of individual bands was not attempted due to the significant overlap of vibrational bands in the experimental spectra.

Thermal response of the F region ionosphere in artificial modification experiments by HF radio waves

NASA Technical Reports Server (NTRS)