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Sample records for facet joint syndrome

  1. Lumbar facet syndromes.

    PubMed

    Beresford, Zach M; Kendall, Richard W; Willick, Stuart E

    2010-01-01

    Low back pain is a common presenting complaint to sports medicine providers. The lumbar spine is a complex anatomic structure with multiple potential pain generators. Epidemiologic studies have shown that the intervertebral disc is the most common pain generator in all patients with low back pain. The facet joints may account for 15%-40% of low back pain. It can be challenging at times to establish a firm diagnosis of facet pain. Facet pain can have different presentations, and pain emanating from other lumbopelvic structures can present similarly as facet joint pain. This article reviews the anatomy and biomechanics of the lumbar facet joints, presenting symptoms and physical examination findings seen with facet pain. We also will discuss diagnostic and treatment paradigms that are helpful to the clinician treating low back pain in athletes.

  2. [Septic arthritis of thoracic facet joint].

    PubMed

    Ben Abdelghani, K; Gérard-Dran, D; Combe, B

    2009-08-01

    Septic arthritis of the facet joint is a rare condition. We report a case of septic arthritis of both a thoracic facet joint and a wrist. Clinical manifestations were consistent with a spondylodiscitis. Magnetic resonance imaging of the spine demonstrated infection of facet joints of T1 and T2. A surgical biopsy of the wrist isolated a type B streptococcus. The same organism was found in urine culture. The patient had an uneventful recovery on antibiotics.

  3. Facet joint laser radiation: tissue effects of a new clinical laser application

    NASA Astrophysics Data System (ADS)

    Werkmann, Klaus; Thal, Dietmar R.

    1996-01-01

    Chronic unilateral and bilateral back pain with pseudoradicular symptoms, is a common clinical syndrome, which in many cases can be related to the facet joint syndrome. The pain is caused by mechanical affection of synovial and capsular nerve terminals. Therefore, current therapeutical attempts including physical therapy, intra-articular injection of local anesthetics and steroids and thermocoagulation of the facet joint with a thermocoagulator, are performed. We confirmed laser coagulation of the facet joint. Porcine cadaveric spines were treated immediately after death by intra-articular facet joint laser radiation. With the pulsed Nd:YAG laser (1064 nm) altogether 600 J were applied in three different places 4 mm apart at the top of the facet joint. The results showed that facet joint laser radiation leads to a small (about 1 - 2 mm diameter) lesion restricted to the facet joint cavity and its synovia. Histologically, we found a central carbonization zone and necrosis, including almost the whole cartilage and approximately 0.2 mm of the adjacent bone. These changes are similar to Nd:Yag-laser applications in other skeletal regions. It is suggested that these changes may lead to facet joint denervation by coagulation of the synovial nerve terminals. Cicatration of the laser lesion might cause ankylosis of this joint. In sum, facet joint laser radiation could be an alternative therapeutical tool for lower back pain of the facet joint syndrome type. Therefore, future clinical application of this technique seems to be very promising.

  4. [Interventions on facet joints. Techniques of facet joint injection, medial branch block and radiofrequency ablation].

    PubMed

    Artner, J; Klessinger, S

    2015-10-01

    Fluoroscopy-guided interventions on facet joints have been used for decades for the symptomatic management of pain in spinal disorders. A large number of imaging techniques are used to achieve a precise and safe needle placement in interventional procedures. Pulsed fluoroscopy is one of the most widely used and well-accepted tools for these procedures. This article presents a technical overview of commonly used fluoroscopy-guided interventions on the facet joints of the cervical and lumbar spine, such as facet joint injection, blockade of the medial nerve branches and radiofrequency ablation.

  5. Management of lumbar zygapophysial (facet) joint pain

    PubMed Central

    Manchikanti, Laxmaiah; Hirsch, Joshua A; Falco, Frank JE; Boswell, Mark V

    2016-01-01

    AIM: To investigate the diagnostic validity and therapeutic value of lumbar facet joint interventions in managing chronic low back pain. METHODS: The review process applied systematic evidence-based assessment methodology of controlled trials of diagnostic validity and randomized controlled trials of therapeutic efficacy. Inclusion criteria encompassed all facet joint interventions performed in a controlled fashion. The pain relief of greater than 50% was the outcome measure for diagnostic accuracy assessment of the controlled studies with ability to perform previously painful movements, whereas, for randomized controlled therapeutic efficacy studies, the primary outcome was significant pain relief and the secondary outcome was a positive change in functional status. For the inclusion of the diagnostic controlled studies, all studies must have utilized either placebo controlled facet joint blocks or comparative local anesthetic blocks. In assessing therapeutic interventions, short-term and long-term reliefs were defined as either up to 6 mo or greater than 6 mo of relief. The literature search was extensive utilizing various types of electronic search media including PubMed from 1966 onwards, Cochrane library, National Guideline Clearinghouse, clinicaltrials.gov, along with other sources including previous systematic reviews, non-indexed journals, and abstracts until March 2015. Each manuscript included in the assessment was assessed for methodologic quality or risk of bias assessment utilizing the Quality Appraisal of Reliability Studies checklist for diagnostic interventions, and Cochrane review criteria and the Interventional Pain Management Techniques - Quality Appraisal of Reliability and Risk of Bias Assessment tool for therapeutic interventions. Evidence based on the review of the systematic assessment of controlled studies was graded utilizing a modified schema of qualitative evidence with best evidence synthesis, variable from level I to level V

  6. Three-dimensional evaluation of the facet joints

    NASA Astrophysics Data System (ADS)

    Folio, Les R.

    1990-04-01

    Computerized tomography and magnetic resonance imaging nave revolurionalized analysis of vertebral anatomy and pathology. Further advances with 3-dimensional imaging have recently become an important adjunct for diagnosis and treatment in structural abnormalities. Facets are intimately related to their surrounding musculature and malalignment may cause pain directly or indirectly. High resolution 3-dimensional reformations of CT Scans give us new insight on structure and function of facet joints, since their motion and architecture are ever complex. It is well documented in the literature that facet joint biomecnanics is a partial contributor to the myriad at causes of low back The term "facet Joint syndrome" was coined in 1933 by GhorMley.3 The osteopathic lesion complex is well defined by LeRoy and McCole and comparison of roentgenographic findings before and after manipulation has teen described by Long and Lioyd.4,5 since alterations in facet biamechanics are an important aspect of osteopathic manipulative therapy (OT), 3-dimensional hign resolution imaging will prove to be a great asset in osteopathic research. Rotating the spine allows for different viewing perspectives to provide optimal and consistent measurements of the facet joint. Rotations are performed on the X, Y and 7, axis and measurements pre and post-manipulation are performed and compared on matching axis and perspectives. Rotation about the X, Y and Z axis help appreciate the 3-dimensionality of the vertebral column to project to the viewer a feeling that the spine is floating in space before them. This does give the viewer a 3-D understanding of the object however, only at a perspective at a Lime.

  7. Facet joint disturbance induced by miniscrews in plated cervical laminoplasty

    PubMed Central

    Chen, Hua; Li, Huibo; Wang, Beiyu; Li, Tao; Gong, Quan; Song, Yueming; Liu, Hao

    2016-01-01

    Abstract A retrospective cohort study. Plated cervical laminoplasty is an increasingly common technique. A unique facet joint disturbance induced by lateral mass miniscrews penetrating articular surface was noticed. Facet joints are important to maintain cervical spine stability and kinetic balance. Whether this facet joint disturbance could affect clinical and radiologic results is still unknown. The objective of this study is to investigate the clinical and radiologic outcomes of patients with facet joints disturbance induced by miniscrews in plated cervical laminoplasty. A total of 105 patients who underwent cervical laminoplasty with miniplate fixation between May 2010 and February 2014 were comprised. Postoperative CT images were used to identify whether facet joints destroyed by miniscrews. According to facet joints destroyed number, all the patients were divided into: group A (none facet joint destroyed), group B (1–2 facet joints destroyed), and group C (≥3 facet joints destroyed). Clinical data (JOA, VAS, and NDI scores), radiologic data (anteroposterior diameter and Palov ratio), and complications (axial symptoms and C5 palsy) were evaluated and compared among the groups. There were 38, 40, and 27 patients in group A, B, and C, respectively. The overall facet joints destroyed rate was 30.7%. All groups gained significant JOA and NDI scores improvement postoperatively. The preoperative JOA, VAS, NDI scores, and postoperative JOA scores did not differ significantly among the groups. The group C recorded significant higher postoperative VAS scores than group A (P = 0.002) and B (P = 0.014) and had significant higher postoperative NDI scores than group A (P = 0.002). The pre- and postoperative radiologic data were not significant different among the groups. The group C had a significant higher axial symptoms incidence than group A (12/27 vs 8/38, P = 0.041). Facet joints disturbance caused by miniscrews in plated cervical laminoplasty may not influence

  8. Facet joint changes after application of lumbar nonfusion dynamic stabilization.

    PubMed

    Lee, Soo Eon; Jahng, Tae-Ahn; Kim, Hyun Jib

    2016-01-01

    OBJECTIVE The long-term effects on adjacent-segment pathology after nonfusion dynamic stabilization is unclear, and, in particular, changes at the adjacent facet joints have not been reported in a clinical study. This study aims to compare changes in the adjacent facet joints after lumbar spinal surgery. METHODS Patients who underwent monosegmental surgery at L4-5 with nonfusion dynamic stabilization using the Dynesys system (Dynesys group) or transforaminal lumbar interbody fusion with pedicle screw fixation (fusion group) were retrospectively compared. Facet joint degeneration was evaluated at each segment using the CT grading system. RESULTS The Dynesys group included 15 patients, while the fusion group included 22 patients. The preoperative facet joint degeneration CT grades were not different between the 2 groups. Compared with the preoperative CT grades, 1 side of the facet joints at L3-4 and L4-5 had significantly more degeneration in the Dynesys group. In the fusion group, significant facet joint degeneration developed on both sides at L2-3, L3-4, and L5-S1. The subjective back and leg pain scores were not different between the 2 groups during follow-up, but functional outcome based on the Oswestry Disability Index improved less in the fusion group than in the Dynesys group. CONCLUSIONS Nonfusion dynamic stabilization using the Dynesys system had a greater preventative effect on facet joint degeneration in comparison with that obtained using fusion surgery. The Dynesys system, however, resulted in facet joint degeneration at the instrumented segments and above. An improved physiological nonfusion dynamic stabilization system for lumbar spinal surgery should be developed.

  9. Uncovertebral joint injury in cervical facet dislocation: the headphones sign.

    PubMed

    Palmieri, Francesco; Cassar-Pullicino, Victor N; Dell'Atti, Claudia; Lalam, Radhesh K; Tins, Bernhard J; Tyrrell, Prudencia N M; McCall, Iain W

    2006-06-01

    The purpose of our study is to demonstrate the uncovertebral mal-alignment as a reliable indirect sign of cervical facet joint dislocation. We examined the uncovertebral axial plane alignment of 12 patients with unilateral and bilateral cervical facet joint dislocation (UCFJD and BCFJD, respectively), comparing its frequency to the reverse hamburger bun sign on CT and MR axial images. Of the seven cases with BCFJD, five clearly demonstrated the diagnostic reverse facet joint hamburger bun sign on CT and MR images, but in two cases this sign was not detectable. In the five cases with UCFJD, four demonstrated the reverse hamburger bun sign on both CT and MRI. In one case the reverse hamburger bun sign was not seen adequately with either image modality, but the facet dislocation was identified on sagittal imaging. The uncovertebral mal-alignment was detected in all 12 cases. Normally, the two components of the uncovertebral joint enjoy a concentric relationship that in the axial plane is reminiscent of the relationship of headphones with the wearer's head. We name this appearance the 'headphones' sign. Radiologists should be aware of the headphones sign as a reliable indicator of facet joint dislocation on axial imaging used in the assessment of cervical spine injuries.

  10. Epiduroscopic Removal of a Lumbar Facet Joint Cyst

    PubMed Central

    Jin, Hyun Seung; Bae, Jun Yeol; In, Chi Bum; Choi, Eun Joo; Lee, Pyung Bok

    2015-01-01

    Facet joint synovial cysts are usually associated with osteoarthritis of the adjacent facet joint and/or spondylolisthesis. In between the conservative and operative ends of the treatment spectrum lie minimally invasive techniques such as cyst rupture using epiduroscopy. In this report, we describe an 82-year-old male patient presenting with low back pain radiating to his lower left extremity and associated paresthesia. Magnetic resonance imaging of the lumbar spine revealed a synovial cyst at left L4/5 facet joint. Using epiduroscopy, the cyst was mechanically ruptured by popping it with the tip of the scope. The patient remained symptom-free at his successive visits until 12 months after the procedure, and was opened for desired follow up. PMID:26495082

  11. Lumbar facet injection for the treatment of chronic piriformis myofascial pain syndrome: 52 case studies

    PubMed Central

    Huang, Jen-Ting; Chen, Han-Yu; Hong, Chang-Zern; Lin, Ming-Ta; Chou, Li-Wei; Chen, Hsin-Shui; Tsai, Chien-Tsung; Chang, Wen-Dien

    2014-01-01

    Background and aims The aim of this study was to demonstrate the effectiveness of lumbar facet joint injection for piriformis myofascial pain syndrome. Methods Fifty-two patients with chronic myofascial pain in the piriformis muscle each received a lumbar facet injection into the ipsilateral L5–S1 facet joint region, using the multiple insertion technique. Subjective pain intensity, trunk extension range, and lumbar facet signs were measured before, immediately after, and 2 weeks after injection. Thirty-six patients received follow-up for 6 months. Results Immediately after the injection, 27 patients (51.9%) had complete pain subsidence, 19 patients (36.5%) had pain reduction to a tolerable level, and only 6 patients (11.5%) had no pain relief to a tolerable level. Mean pain intensity was reduced from 7.4±0.9 to 1.6±2.1 after injection (P<0.01). This effectiveness lasted for 2 weeks in 49 patients (94.2%), and lasted for approximately 6 months in 35 (97.2%) of 36 patients. The mean range of motion increased from 13.4±6.8 degrees to 22.1±6.0 degrees immediately after injection, and further increased 2 weeks and 6 months later. Immediately after injection, 45 patients (86.5%) had no facet sign. In addition, 90.4% and 94.4% of patients had no facet sign after 2 weeks and after 6 months, respectively. Conclusions It is important to identify the possible cause of piriformis myofascial pain syndrome. If this pain is related to lumbar facet lesions, lumbar facet joint injection can immediately suppress piriformis myofascial pain symptoms. This effectiveness may last for at least 6 months in most patients. This study further supports the importance of eliminating the underlying etiological lesion for complete and effective relief of myofascial pain syndrome. PMID:25170256

  12. Percutaneous cryodenervation of lumbar facet joints: a prospective clinical trial

    PubMed Central

    Veihelmann, A.; Trouillier, H.; Hausdorf, J.; Devens, C.; Wegener, B.; Jansson, V.; von Schulze Pellengahr, C.

    2006-01-01

    Facet joint pain is an important aspect of degenerative lumbar spine disease, and radiofrequency medial branch neurotomy remains an established therapy, while cryodenervation has still been poorly examined. This study was undertaken to examine the effects of medial branch cryodenervation in the treatment of lumbar facet joint pain. This was a prospective clinical case series. Patient selection was based on the history, physical examination and positive medial branch blocks. Percutaneous medial branch cryodenervation was performed using a Lloyd Neurostat 2000. Target parameters were low back pain (VAS), limitation of activity (McNab) and overall satisfaction. Fifty patients were recruited, and 46 completed the study. The follow-up time was 1 year. At 6 weeks, 33 patients (72%) were pain free or had major improvement of low back pain; 13 (28%) had no or little improvement. Including failures, mean low back pain decreased significantly from 7.7 preoperatively to 3.2 at 6 weeks, 3.3 at 3 months, 3.0 at 6 months and 4.2 at 12 months (P<0.0001). Limitation of the activities of daily living improved parallel to reduced pain. Our results suggest that medial branch cryodenervation is a safe and effective treatment for lumbar facet joint pain. PMID:16927087

  13. Utilization of Facet Joint and Sacroiliac Joint Interventions in Medicare Population from 2000 to 2014: Explosive Growth Continues!

    PubMed

    Manchikanti, Laxmaiah; Hirsch, Joshua A; Pampati, Vidyasagar; Boswell, Mark V

    2016-10-01

    Increasing utilization of interventional techniques in managing chronic spinal pain, specifically facet joint interventions and sacroiliac joint injections, is a major concern of healthcare policy makers. We analyzed the patterns of utilization of facet and sacroiliac joint interventions in managing chronic spinal pain. The results showed significant increase of facet joint interventions and sacroiliac joint injections from 2000 to 2014 in Medicare FFS service beneficiaries. Overall, the Medicare population increased 35 %, whereas facet joint and sacroiliac joint interventions increased 313.3 % per 100,000 Medicare population with an annual increase of 10.7 %. While the increases were uniform from 2000 to 2014, there were some decreases noted for facet joint interventions in 2007, 2010, and 2013, whereas for sacroiliac joint injections, the decreases were noted in 2007 and 2013. The increases were for cervical and thoracic facet neurolysis at 911.5 % compared to lumbosacral facet neurolysis of 567.8 %, 362.9 % of cervical and thoracic facet joint blocks, 316.9 % of sacroiliac joints injections, and finally 227.3 % of lumbosacral facet joint blocks. PMID:27646014

  14. Percutaneous Facet Screw Fixation in the Treatment of Symptomatic Recurrent Lumbar Facet Joint Cyst: A New Technique.

    PubMed

    Amoretti, Nicolas; Gallo, Giacomo; Bertrand, Anne-Sophie; Bard, Robert L; Kelekis, Alexis

    2016-01-01

    We present a case of percutaneous treatment of symptomatic recurrent lumbar facet joint cyst resistant to all medical treatments including facet joint steroid injection. Percutaneous transfacet fixation was then performed at L4-L5 level with a cannulated screw using CT and fluoroscopy guidance. The procedure time was 30 min. Using the visual analog scale (VAS), pain decreased from 9.5, preoperatively, to 0 after the procedure. At 6-month follow-up, an asymptomatic cystic recurrence was observed, which further reduced at the 1-year follow-up. Pain remained stable (VAS at 0) during all follow-ups. CT- and fluoroscopy-guided percutaneous cyst rupture associated with facet screw fixation could be an alternative to surgery in patients suffering from a symptomatic recurrent lumbar facet joint cyst.

  15. Joint hypermobility syndrome.

    PubMed

    Fikree, Asma; Aziz, Qasim; Grahame, Rodney

    2013-05-01

    Although perceived as a rare condition, joint hypermobility syndrome is common. Its prevalence in rheumatology clinics is extremely high. Early estimates suggest that it may be the most common of all rheumatologic conditions. The problem lies in the general lack of awareness of the syndrome, its means of recognition, and the resultant failure to diagnose it correctly when present. It is a worldwide problem. This article provides an overview of hypermobility and hypermobility syndrome, stressing its multisystemic nature and the negative impact that it may have on quality of life, with particular reference to gastrointestinal involvement. PMID:23597972

  16. Joint hypermobility syndrome pain.

    PubMed

    Grahame, Rodney

    2009-12-01

    Joint hypermobility syndrome (JHS) was initially defined as the occurrence of musculoskeletal symptoms in the presence of joint laxity and hypermobility in otherwise healthy individuals. It is now perceived as a commonly overlooked, underdiagnosed, multifaceted, and multisystemic heritable disorder of connective tissue (HDCT), which shares many of the phenotypic features of other HDCTs such as Marfan syndrome and Ehlers-Danlos syndrome. Whereas the additional flexibility can confer benefits in terms of mobility and agility, adverse effects of tissue laxity and fragility can give rise to clinical consequences that resonate far beyond the confines of the musculoskeletal system. There is hardly a clinical specialty to be found that is not touched in one way or another by JHS. Over the past decade, it has become evident that of all the complications that may arise in JHS, chronic pain is arguably the most menacing and difficult to treat. PMID:19889283

  17. Morphometric Study of Clavicular Facet of Coracoclavicular Joint in Adult Indian Population

    PubMed Central

    Mahajan, Anita; Vasudeva, Neelam

    2016-01-01

    Introduction Anthropologists have used Coracoclavicular Joint (CCJ), a non-metric anatomical variant in population, as a marker for population migration from prehistoric times to present. Aim The aim of this osteological study was to determine the incidence and morphometry of articular facet of CCJ on conoid tubercle of clavicle in Indian population, as Indian studies are scanty and incomplete. Materials and Methods The study was done on 144 adult human clavicles (76 right and 68 left; 93 males and 51 females) collected from osteology museum in Department of Anatomy, Maulana Azad Medical College, New Delhi, India. The presence of articular facet on the conoid tubercle was determined and Maximum Antero-Posterior (MAPD) and maximum transverse diameter (MTD) was measured by digital vernier calliper. The incidence was compared on the basis of sex, side and with other osteological studies in the world. Statistical analysis was done using the Chi-Square test for nominal categorical data and student’s t-test for normally distributed continuous variables in Microsoft Excel 2007 to assess the relationship between the examined variables. Results Articular facet on conoid tubercle was found in 8 cases (5.6%). Seven (9.2%) were present on the right side and one (1.5%) on the left side. Seven cases (7.5%) were present in males and one case (2%) was found in females. The facets were generally oval, with MAPD and MTD of 12.28 and 17.17 mm respectively. A significant side variation was present with right sided facet being more common. The left sided facet was more transversely elongated than right. In males, the facets were more elongated antero-posteriorly than in females. Conclusion The Indian population showed an incidence of 5.6%, which was comparable to other ethnic groups in world population. The morphometric and side differences could be attributed to the occupational factors and range of movements associated with the CCJ. The CCJ should be borne in mind as a differential

  18. Encapsulated Ruffini-like endings in human lumbar facet joints

    PubMed Central

    VANDENABEELE, F.; CREEMERS, J.; LAMBRICHTS, I.; LIPPENS, P.; JANS, M.

    1997-01-01

    The innervation of the human lumbar facet joint capsule was studied by light and electron microscopy. Small numbers of encapsulated corpuscular endings were identified in the dense fibrous layer. Clusters of 2 types of endings were found: small cylindrical corpuscles (type 1) and large fusiform corpuscles (type 2). The corpuscles were classified structurally as Ruffini-type endings. The 1st type was predominant and characterised by a compartmentalised receptor complex, a thin perineurial capsule and a narrow subcapsular space. The 2nd type was characterised by a thicker perineurial capsule, a ‘spindle-like’ receptive complex, and an extensive subcapsular space with capillaries and concentrically oriented fibroblast-like cells. Both types of endings were innervated mainly by thinly myelinated group III (A delta) and unmyelinated group IV (C) nerve fibres that branched and terminated in the receptor complex. Their sensory endings were intimately related to the collagen fibre bundles as multiple enlarged axonal segments (‘beads’) with ultrastructural features which were characteristic of receptive sites: an accumulation of mitochondria and vesicles, and ‘bare’ areas of axolemma lacking a Schwann cell investment but covered by a thin basal lamina. Some beads in the 2nd type of ending contained granular vesicles, 30–60 mm in diameter, resembling sympathetic nerve endings. Small diameter collagen fibrils situated within multilayered basal laminae were found among the multiple receptive sites in the receptive complex in both types of ending. Their possible functional significance in mechanoreception is discussed. Particular attention has been given to their apparent variable orientation to the mechanoreceptive site. PMID:9449076

  19. Material Properties of the Human Lumbar Facet Joint Capsule

    PubMed Central

    Little, Jesse S.; Khalsa, Partap S.

    2005-01-01

    The human facet joint capsule is one of the structures in the lumbar spine that constrains motions of vertebrae during global spine loading (e.g., physiological flexion). Computational models of the spine have not been able to include accurate nonlinear and viscoelastic material properties, as they have not previously been measured. Capsules were tested using a uniaxial ramp-hold protocol or a haversine displacement protocol using a commercially available materials testing device. Plane strain was measured optically. Capsules were tested both parallel and perpendicular to the dominant orientation of the collagen fibers in the capsules. Viscoelastic material properties were determined. Parallel to the dominant orientation of the collagen fibers, the complex modulus of elasticity was E* = 1.63MPa, with a storage modulus of E′ = 1.25MPa and a loss modulus of: E″ = 0.39MPa. The mean stress relaxation rates for static and dynamic loading were best fit with first-order polynomials: B (ɛ) = 0.1110 ɛ − 0.0733 and B (ɛ) = −0.1249ɛ 11794-8181 +0.0190, respectively. Perpendicular to the collagen fiber orientation, the viscous and elastic secant moduli were 1.81 and 1.00 MPa, respectively. The mean stress relaxation rate for static loading was best fit with a first-order polynomial: B (ɛ) = − 0.04ɛ − 0.06. Capsule strength parallel and perpendicular to collagen fiber orientation was 1.90 and 0.95 MPa, respectively, and extensibility was 0.65 and 0.60, respectively. Poisson’s ratio parallel and perpendicular to fiber orientation was 0.299 and 0.488, respectively. The elasticity moduli were nonlinear and anisotropic, and capsule strength was larger aligned parallel to the collagen fibers. The phase lag between stress and strain increased with haversine frequency, but the storage modulus remained large relative to the complex modulus. The stress relaxation rate was strain dependent parallel to the collagen fibers, but was strain independent perpendicularly

  20. Relationships between joint motion and facet joint capsule strain during cat and human lumbar spinal motions

    PubMed Central

    Ianuzzi, Allyson; Pickar, Joel G; Khalsa, Partap S

    2011-01-01

    Objective The lumbar facet joint capsule (FJC) is innervated with mechanically sensitive neurons and is thought to contribute to proprioception and pain. Biomechanical investigations of the FJC have commonly used human cadaveric spines, while combined biomechanical and neurophysiological studies have typically used non-human animal models. The purpose of this study was develop mathematical relationships describing vertebral kinematics and facet joint capsule strain in cat and human lumbar spine specimens during physiological spinal motions in order to facilitate future efforts at understanding the mechanosensory role of the FJC. Methods Cat lumbar spine specimens were tested during extension, flexion and lateral bending. Joint kinematics and FJC principal strain were measured optically. FJC strain-intervertebral angle (IVA) regression relationships were established for the three most caudal lumbar joints using cat (current study) and human (prior study) data. FJC strain-IVA relationships were utilized to estimate cat and human spine kinematics that corresponded to published sensory neuron response thresholds for low threshold mechanoreceptors (5% and 10%). Results Significant linear relationships between IVA and strain were observed for both human and cat during motions that produced tension in the FJCs (p<0.01). During motions that produced tension in the FJCs, the models predicted that FJC strain magnitudes corresponding to published sensory neuron response thresholds would be produced by IVA magnitudes within the physiological range of lumbar motion. Conclusions Data from the current study support the proprioceptive role of lumbar spine FJC and low threshold mechanoreceptive afferents, and can be utilized in interpreting combined neurophysiological and biomechanical studies of cat lumbar spines. PMID:21875516

  1. Osteochondroma arising from a lumbar facet joint in a 16-year-old.

    PubMed

    Hancock, Graeme E; Mariathas, Chrishan; Fernandes, James A; Breakwell, Lee M; Cole, Ashley A; Michael, Antony L R

    2015-05-01

    Osteochondromas are benign tumours of bony or cartilaginous origin, which may be solitary or multiple. They are rare in the axial skeleton and have previously been reported to arise from facet joints only in four cases in the English literature. We report the case of a 16-year-old girl who presented with a palpable bony lump and a short history of back pain. Imaging showed a bony lesion arising from a left-sided facet joint in the lumbar spine. Following excision biopsy, there was complete resolution of symptoms. The literature on the origin and management of spinal osteochondromas is discussed.

  2. Delayed onset of a spinal epidural hematoma after facet joint injection

    PubMed Central

    Velickovic, Mirko; Ballhause, Tobias M

    2016-01-01

    The treatment of chronic back pain is a challenging problem. Facet joint infiltration is an established treatment for chronic low back pain caused by arthrosis of the lumbar facet joints. Due to the increasing number of patients with chronic low back pain, this therapy has become more frequent. We treated a 51-year-old male patient, who developed an epidural hematoma 2 months after infiltration therapy. Our case shows that even a delayed onset of spinal epidural hematoma is possible and should be kept in mind as a possible cause of acute myelopathy after spinal intervention. PMID:27803810

  3. Facet joint disturbance induced by miniscrews in plated cervical laminoplasty: Dose it influence the clinical and radiologic outcomes?

    PubMed

    Chen, Hua; Li, Huibo; Wang, Beiyu; Li, Tao; Gong, Quan; Song, Yueming; Liu, Hao

    2016-09-01

    A retrospective cohort study. Plated cervical laminoplasty is an increasingly common technique. A unique facet joint disturbance induced by lateral mass miniscrews penetrating articular surface was noticed. Facet joints are important to maintain cervical spine stability and kinetic balance. Whether this facet joint disturbance could affect clinical and radiologic results is still unknown. The objective of this study is to investigate the clinical and radiologic outcomes of patients with facet joints disturbance induced by miniscrews in plated cervical laminoplasty.A total of 105 patients who underwent cervical laminoplasty with miniplate fixation between May 2010 and February 2014 were comprised. Postoperative CT images were used to identify whether facet joints destroyed by miniscrews. According to facet joints destroyed number, all the patients were divided into: group A (none facet joint destroyed), group B (1-2 facet joints destroyed), and group C (≥3 facet joints destroyed). Clinical data (JOA, VAS, and NDI scores), radiologic data (anteroposterior diameter and Palov ratio), and complications (axial symptoms and C5 palsy) were evaluated and compared among the groups.There were 38, 40, and 27 patients in group A, B, and C, respectively. The overall facet joints destroyed rate was 30.7%. All groups gained significant JOA and NDI scores improvement postoperatively. The preoperative JOA, VAS, NDI scores, and postoperative JOA scores did not differ significantly among the groups. The group C recorded significant higher postoperative VAS scores than group A (P = 0.002) and B (P = 0.014) and had significant higher postoperative NDI scores than group A (P = 0.002). The pre- and postoperative radiologic data were not significant different among the groups. The group C had a significant higher axial symptoms incidence than group A (12/27 vs 8/38, P = 0.041).Facet joints disturbance caused by miniscrews in plated cervical laminoplasty may not influence neurological

  4. Talocalcaneal Joint Middle Facet Coalition Resection With Interposition of a Juvenile Hyaline Cartilage Graft.

    PubMed

    Tower, Dyane E; Wood, Ryan W; Vaardahl, Michael D

    2015-01-01

    Talocalcaneal joint middle facet coalition is the most common tarsal coalition, occurring in ≤2% of the population. Fewer than 50% of involved feet obtain lasting relief of symptoms after nonoperative treatment, and surgical intervention is commonly used to relieve symptoms, increase the range of motion, improve function, reconstruct concomitant pes planovalgus, and prevent future arthrosis from occurring at the surrounding joints. Several approaches to surgical intervention are available for patients with middle facet coalitions, ranging from resection to hindfoot arthrodesis. We present a series of 4 cases, in 3 adolescent patients, of talocalcaneal joint middle facet coalition resection with interposition of a particulate juvenile hyaline cartilaginous allograft (DeNovo(®) NT Natural Tissue Graft, Zimmer, Inc., Warsaw, IN). With a mean follow-up period of 42.8 ± 2.9 (range 41 to 47) months, the 3 adolescent patients in the present series were doing well with improved subtalar joint motion and decreased pain, and 1 foot showed no bony regrowth on a follow-up computed tomography scan. The use of a particulate juvenile hyaline cartilaginous allograft as interposition material after talocalcaneal middle facet coalition resection combined with adjunct procedures to address concomitant pes planovalgus resulted in good short-term outcomes in 4 feet in 3 adolescent patients. PMID:25922335

  5. Chronic unilateral locked facet joint with spinal cord injury in a 26-month-old child: A case report

    PubMed Central

    Wu, Ai-Min; Wang, Xiang-Yang; Luo, Peng; Xu, Hua-Zi; Chi, Yong-Long

    2015-01-01

    Objectives This study presents the successful posterior surgical reduction and fusion on a 26-month-old child with chronic unilateral locked facet joint and spinal cord injury (SCI). Methods A 26-month-old child with chronic unilateral locked facet joint and SCI treated by posterior surgical reduction and fusion. Plaster external fixation was applied and rehabilitation exercise was trained post-operatively. Results Chronic unilateral locked facet joint was reduced successfully and bone fusion of C4/5 was achieved 3 months after surgery. The function of both lower limbs was improved 1 year after surgery, aided with physical rehabilitation. Conclusion Unilateral locked facet joint in pediatric population is rare. Few clinical experiences were found in the literature. Non-surgical treatment has advantages of not being invasive and is preferred for acute patients; however, it may not be suitable for chronic unilateral locked facet joint with SCI, in which surgical intervention is needed. PMID:24673578

  6. Navigated Pin-Point Approach to Osteoid Osteoma Adjacent to the Facet Joint of Spine

    PubMed Central

    Neo, Masashi; Takemoto, Mitsuru; Nishizawa, Kazuya; Imai, Shinji

    2016-01-01

    Osteoid osteoma (OO) is a benign osteoblastic tumor. Its curative treatment is complete removal of the nidus, where intraoperative localization of the nidus governs clinical results. However, treatment can be difficult since the lesion is often invisible over the bony surface. Accordingly, establishment of an ideal less invasive surgical strategy for spinal OO remains yet unsettled. We illustrate the efficacy of a computed tomography (CT)-based navigation system in excising OO located adjacent to the facet joint of spine. In our 2 cases, complete and pin-point removal of the nidus located close to the facet joint was successfully achieved, without excessive removal of the bone potentially leading to spinal instability and possible damage of nearby neurovascular structures. We advocate a less invasive approach to spinal OO, particularly in an environment with an available CT-based navigation system. PMID:26949472

  7. Biomechanical, Biochemical, and Histological Characterization of Canine Lumbar Facet Joint Cartilage

    PubMed Central

    Elder, Benjamin D.; Vigneswaran, Krishanthan; Athanasiou, Kyriacos A.; Kim, Daniel H.

    2011-01-01

    Object Tissue engineering appears to be a promising strategy for articular cartilage regeneration as a treatment for facet joint arthritis. Prior to the commencement of tissue engineering approaches, design criteria must be established to determine the required functional properties of the replacement tissue. As characterization of functional properties of facet joint cartilage has not been performed previously, the objective of this study was to determine the biomechanical, biochemical, and histological properties of facet joint cartilage. Methods The in vitro testing was conducted using four lumbar spinal segments obtained from skeletally mature canines. In each specimen, articular cartilage was obtained from the superior surface of the L3–L4 and L4–L5 facet joints. Creep indentation was used to determine the compressive biomechanical properties, while uniaxial tensile testing yielded the Young’s modulus and ultimate tensile strength of the tissue. Additionally, biochemical assessments included determinations of cellularity, GAG content, and collagen content, as well as ELISAs for collagen I and II production. Finally, histological characterization included H&E staining, as well as staining for collagen and GAG distributions. Results The mean ± standard deviation values were determined. There were no differences between the two levels for any of the assessed properties. Averaged over both levels, the thickness was 0.49±0.10 mm and the hydration was 74.7±1.7%. Additionally, the cells/WW ratio was 6.26±2.66 × 104 cells/mg and the cells/DW ratio was 2.51±1.21 × 105 cells/mg. The GAG/WW was 0.038±0.013 and the GAG/DW was 0.149±0.049 mg/mg, while the collagen/WW was 0.168±0.026 and collagen/DW was 0.681±0.154 mg/mg. Finally, the aggregate modulus was 554±133 kPa, the Young’s modulus was 10.08±8.07 MPa, and the ultimate tensile strength was 4.44±2.40 MPa. Conclusions To the best of our knowledge, this study is the first to provide a functional

  8. Lateral facet syndrome of the patella. Lateral restraint analysis and use of lateral resection.

    PubMed

    Johnson, R P

    1989-01-01

    Thirty-eight knees in 34 patients with an average age of 22 years were diagnosed as having lateral facet syndrome (LFS), a painful compressive arthropathy of the lateral facet of the patella. This diagnosis was based on the physical findings of tenderness at the lateral patellofemoral joint line, tenderness over the vastus lateralis obliquus (VLO) tendon just above the patella, a positive medial apprehension test, and marked resistance to medial patellar displacement with the knee flexed 30 degrees. The most common complaints were patellar pain with activity, pain with prolonged knee flexion, intermittent knee swelling, and giving way. At surgery, the VLO, the lateral retinaculum (LR), and the anterior fibers of the iliotibial tract (ITT) were sequentially divided from the lateral border of the patella. Each was temporarily reattached to a cuff of soft tissue left on the patella using surgical clamps to determine its contribution to lateral restraint. The VLO was found to be the primary restraint in one-half of the knees. In one-third of the knees, all three of the structures contributed equally. In six knees, the primary restraint was the anterior fibers of the ITT, whereas the LR was the primary restraint in only two. The distal ends of these three structures were then resected to prevent rescarring and retethering. At a minimum follow-up period of two years, 87% had satisfactory relief of their patellar pain, had returned to normal activities, and had no or minimal physical findings of LFS. The procedure is recommended for patients who have failed other procedures and in those whose symptoms cannot be controlled by activity modification, exercises, bracing, or medication. PMID:2910595

  9. Does therapist’s attitude affect clinical outcome of lumbar facet joint injections?

    PubMed Central

    Middendorp, Marcus; Kollias, Konstantinos; Ackermann, Hanns; Splettstößer, Annina; Vogl, Thomas J; Khan, M Fawad; Maataoui, Adel

    2016-01-01

    AIM: To investigate if the clinical outcome of intra-articular lumbar facet joint injections is affected by the therapist’s attitude. METHODS: A total of 40 patients with facet joint-associated chronic low back pain were randomly divided into two groups. All patients received computed tomography-guided, monosegmental intra-articular facet joint injections. Following the therapeutic procedure, the patients of the experimental group (EG) held a conversation with the radiologist in a comfortable atmosphere. During the dialog, the patients were encouraged to ask questions and were shown four images. The patients of the control group (CG) left the clinic without any further contact with the radiologist. Outcome was assessed using a pain-based Verbal Numeric Scale at baseline, at 1 wk and at 1, 3, and 6 mo after first treatment. RESULTS: The patient demographics showed no differences between the groups. The patients of the EG received 57 interventional procedures in total, while the patients of the CG received 70 interventional procedures. In both groups, the pain scores decreased significantly over the entire observation period. Compared to the CG, the EG showed a statistically significant reduction of pain at 1 wk and 1 mo post-treatment, while at 3 and 6 mo after treatment, there were no significant differences between both groups. CONCLUSION: Our results show a significant effect on pain relief during the early post-interventional period in the EG as compared to the CG. The basic principle behind the higher efficacy might be the phenomenon of hetero-suggestion. PMID:27358691

  10. Idiopathic septic arthritis of a lumbar facet joint associated with paraspinal abscess.

    PubMed

    Kitova-John, Margarita Borislavova; Azim-Araghi, Ali; Sheikh, Faraz Tariq; Kitov, Borislav Dimitrov

    2015-08-13

    A 48-year-old woman presented with a 1-month history of severe lower back pain on a background of 24 h of mild fever and general tiredness with an associated right-sided foot drop. Five weeks after the onset and with no improvement in symptoms in spite of analgesia and physiotherapy, the patient had a lumbar spine MRI which demonstrated a collection extending from the facet joints of L5 and L6 to the iliacus muscle on the right. A CT-guided aspiration was performed with a lengthy hospital stay for intravenous antibiotic treatment. The culture and sensitivity study of the aspirate isolated Streptococcus pneumoniae.

  11. The Variation in the Lumbar Facet Joint Orientation in an Adult Asian Population and Its Relationship with the Cross-Sectional Area of the Multifidus and Erector Spinae

    PubMed Central

    Katayose, Masaki; Watanabe, Kota

    2016-01-01

    Study Design Cross-sectional study of healthy volunteers. Purpose We aimed to investigate the variation in the lumbar facet joint orientation in an adult Asian population. The relationship between the facet joint orientation and muscle cross-sectional area (CSA) of multifidus and erector spinae was also clarified. Overview of Literature Several studies have reported that lumbar pathologies, such as lumbar spondylolysis and degenerative spondylolisthesis, were related to the horizontally shaped lumbar facet joint orientation at the lower lumbar level. However, data regarding variations in the facet joint orientation in asymptomatic subjects have not been well documented. Methods In 31 healthy male adult Asian volunteers, the facet joint orientation and CSA of multifidus and erector spinae were measured using magnetic resonance imaging at the L4–5 and L5–S1 levels. Variation in the facet joint orientation was examined using coefficients of variation (CV). Pearson's product-moment coefficient was used to investigate the relationship between the facet joint orientation and CSA of multifidus and erector spinae. Results Lumbar facet joint orientation had a wider range of variation at L5–S1 (CV=0.30) than at L4–5 (CV=0.18). The L4–5 facet joint orientation had a weak but significant correlation with the CSA of erector spinae (r=0.40; p=0.031). The CSA of the multifidus had no relationship with the facet joint orientation at the L4–5 (r=0.19; p=0.314) and the L5–S1 level (r=0.19; p=0.312). Conclusions The lumbar facet joint orientation was found to have a wide variation, particularly at the L5–S1 in the Asian adult population, and the facet joint orientation had a relationship with the CSA of the erector spinae at the L4–5. PMID:27790316

  12. Third-degree burn from cooled radiofrequency ablation of medial branch nerves for treatment of thoracic facet syndrome.

    PubMed

    Walega, David; Roussis, Christiana

    2014-07-01

    Radiofrequency ablation of medial branch nerves is considered a safe and effective treatment for chronic facet joint pain in the cervical, thoracic, and lumbosacral spine. Cooled radiofrequency ablation (C-RFA) is gaining popularity over conventional thermal radiofrequency ablation (RFA) in pain management. However, complications of C-RFA have not been reported in the literature. We present a first report of third-degree skin burn resulting from C-RFA electrode use for the treatment of facet syndrome. A 61-year-old woman (BMI of 21.8 kg/m(2) ) with thoracic facet syndrome underwent C-RFA of the T1-4 medial branch nerves (Thoracool System, Baylis Medical Company, Montreal, QC, Canada). Lesioning at the superior-lateral aspect of the thoracic transverse processes at each level was performed. During lesioning of the T2 MBN on the T3 transverse process, skin blanching 15 mm in diameter was noted around the introducer needle with patient complaints of severe, localized pain. Postprocedurally the skin injury at this level worsened in appearance, with a 20 mm × 4 mm skin defect, which took nearly 5 months to heal. With C-RFA, internally cooled electrodes are capable of creating large volume spherical lesions, a size advantage over conventional RFA. Although C-RFA lesion size may overcome the anatomic variability of target nerve location and potentially improve pain outcomes, added vigilance is required in thin patients and in anatomic regions of minimal subcutaneous tissue between the lesion target and the dermis. Skin burns at the site of the RF electrode are a potential risk under such conditions. PMID:24796394

  13. Internal morphology of human facet joints: comparing cervical and lumbar spine with regard to age, gender and the vertebral core

    PubMed Central

    Wilke, Hans-Joachim; Zanker, Daniel; Wolfram, Uwe

    2012-01-01

    Back pain constitutes a major problem in modern societies. Facet joints are increasingly recognised as a source of such pain. Knowledge about the internal morphology and its changes with age may make it possible to include the facets more in therapeutic strategies, for instance joint replacements or immobilisation. In total, 168 facets from C6/7 and L4/5 segments were scanned in a micro-computed tomography. Image analysis was used to investigate the internal morphology with regard to donor age and gender. Additional data from trabecular bone of the vertebral core allowed a semi-quantitative comparison of the morphology of the vertebral core and the facets. Porosity and pore spacing of the cortical sub-chondral bone does not appear to change with age for either males or females. In contrast, bone volume fraction decreases in females from approximately 0.4 to 0.2 , whereas it is constant in males. Trabecular thickness decreases during the ageing process in females and stays constant in males , whereas trabecular separation increases during the ageing process in both genders. The results of this study may help to improve the understanding of pathophysiological changes in the facet joints. Such results could be of value for understanding back pain and its treatment. PMID:22257304

  14. Ultrasound guided, painful electrical stimulation of lumbar facet joint structures: an experimental model of acute low back pain.

    PubMed

    O'Neill, Søren; Graven-Nielsen, Thomas; Manniche, Claus; Arendt-Nielsen, Lars

    2009-07-01

    Quantitative sensory testing has indicated generalized muscle hyperalgesia in patients with chronic low back pain. The temporal development of such hyperalgesia is not well understood. The aim of the present study was to demonstrate whether generalized muscle hyperalgesia can develop within minutes of acute low back pain using a new experimental model of lumbar facet joint pain. Thirteen healthy volunteers were included and baseline pressure pain thresholds were assessed at eight separate sites, outside the area of evoked low back and referred pain. Using ultrasonography, two electrode needles were placed either side of a lumbar facet joint (right L3-4) and used to induce experimental low back pain for 10 min with continuous stimulation. Thresholds, stimulus-response relationships, distribution and quality of the electrically induced pain were recorded. Electrical facet joint stimulation induced low back pain and pain referral into the anterior leg, ipsilaterally, proximal to the knee, similar to what is observed clinically. Pressure pain thresholds did not change significantly before, during and after facet joint stimulation. In conclusion, we describe a novel model of acute experimental low back pain and demonstrate that generalized hyperalgesia did not develop within minutes of acute low back pain. PMID:19376652

  15. Fine structure of vesiculated nerve profiles in the human lumbar facet joint.

    PubMed Central

    Vandenabeele, F; Creemers, J; Lambrichts, I; Robberechts, W

    1995-01-01

    The ultrastructural features of vesiculated nerve profiles were examined within a perivascular plexus of unmyelinated nerve fibres around small arteries and arterioles in the posterior facet joint capsule. Such profiles were exclusively observed in the dense fibrous layer and the adjacent part of the subintimal layer. The ligamentum flavum lacked any type of innervation. The vesiculated nerve profiles were tentatively classified on the basis of the fine structural appearances of their vesicular content. Two major types of nerve profiles could readily be distinguished in the capsular tissue. Both displayed a variable number of mitochondria, neurotubules and neurofilaments. The first type, containing predominantly small vesicles with an electron-dense granule or core, was frequently encountered and considered to be adrenergic in function. Profiles similar in morphology were also observed in the synovial plical tissue. A second type of profile, found in the joint capsule, contained varying proportions of small agranular (clear) vesicles and mitochondria. Some of these profiles exhibited an accumulation of mitochondria and were considered to be sensory in function. Nerve profiles filled with predominantly small flattened vesicles were occasionally encountered. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:8586567

  16. A review of percutaneous techniques for low back pain and neuralgia: current trends in epidural infiltrations, intervertebral disk and facet joint therapies.

    PubMed

    Filippiadis, Dimitrios K; Kelekis, Alexis

    2016-01-01

    Low back pain and neuralgia due to spinal pathology are very common symptoms debilitating numerous patients with peak prevalence at ages between 45 and 60 years. Intervertebral discs and facet joints act as pain sources in the vast majority of the cases. Diagnosis is based on the combination of clinical examination and imaging studies. Therapeutic armamentarium for low back pain and neuralgia due to intervertebral discs and/or facet joints includes conservative therapy, injections, percutaneous therapeutic techniques and surgical options. Percutaneous, therapeutic techniques are imaging-guided, minimally invasive treatments which can be performed as outpatient procedures. In cases of facet joint syndrome, they include, apart from injections, neurolysis with radiofrequency/cryoablation, MR-guided high-intensity focused ultrasound and percutaneous fixation techniques. In case of discogenic pain, apart from infiltrations, therapeutic techniques can be classified in to two main categories: decompression (mechanical, thermal, chemical) techniques and biomaterials implantation/disc cell therapies. Strict sterility measures are a prerequisite and should include extensive local sterility and antibiotic prophylaxis. This article will report clinical and imaging findings for each pathology type and the association with treatment decision. In addition, we will describe in detail all possible treatment techniques for low back pain and neuralgia, and we will report recently published results of these techniques summarizing the data concerning safety and effectiveness as well as the level of evidence. Finally, we will try to provide a rational approach for the therapy of low back pain and neuralgia by means of minimally invasive imaging-guided percutaneous techniques.

  17. Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity

    PubMed Central

    Dong, Ling; Quindlen, Julia C.; Lipschutz, Daniel E.; Winkelstein, Beth A.

    2012-01-01

    The cervical facet joint and its capsule are a common source of neck pain from whiplash. Mechanical hyperalgesia elicited by painful facet joint distraction is associated with spinal neuronal hyperexcitability that can be induced by transmitter/receptor systems that potentiate the synaptic activation of neurons. This study investigated the temporal response of a glutamate receptor and transporters in the dorsal root ganglia (DRG) and spinal cord. Bilateral C6/C7 facet joint distractions were imposed in the rat either to produce behavioral sensitivity or without inducing any sensitivity. Neuronal metabotropic glutamate receptor-5 (mGluR5) and protein kinase C-epsilon (PKCε) expression in the DRG and spinal cord were evaluated on days 1 and 7. Spinal expression of a glutamate transporter, excitatory amino acid carrier 1 (EAAC1), was also quantified at both time points. Painful distraction produced immediate behavioral hypersensitivity that was sustained for 7 days. Increased expression of mGluR5 and PKCε in the DRG was not evident until day 7 and only following painful distraction; this increase was observed in small-diameter neurons. Only painful facet joint distraction produced a significant increase (p<0.001) in neuronal mGluR5 over time, and this increase also was significantly elevated (p ≤ 0.05) over responses in the other groups at day 7. However, there were no differences in spinal PKCε expression on either day or between groups. Spinal EAAC1 expression was significantly increased (p<0.03) only in the nonpainful groups on day 7. Results from this study suggest spinal glutamatergic plasticity is selectively modulated in association with facet-mediated pain. PMID:22578356

  18. Explosive growth of facet joint interventions in the medicare population in the United States: a comparative evaluation of 1997, 2002, and 2006 data

    PubMed Central

    2010-01-01

    Background The Office of Inspector General of the Department of Health and Human Services (OIG-DHHS) issued a report which showed explosive growth and also raised questions of lack of medical necessity and/or indications for facet joint injection services in 2006. The purpose of the study was to determine trends of frequency and cost of facet joint interventions in managing spinal pain. Methods This analysis was performed to determine trends of frequency and cost of facet joint Interventions in managing spinal pain, utilizing the annual 5% national sample of the Centers for Medicare and Medicaid Services (CMS) for 1997, 2002, and 2006. Outcome measures included overall characteristics of Medicare beneficiaries receiving facet joint interventions, utilization of facet joint interventions by place of service, by specialty, reimbursement characteristics, and other variables. Results From 1997 to 2006, the number of patients receiving facet joint interventions per 100,000 Medicare population increased 386%, facet joint visits increased 446%, and facet joint interventions increased 543%. The increases were higher in patients aged less than 65 years compared to those 65 or older with patients increasing 504% vs. 355%, visits increasing 587% vs. 404%, and services increasing 683% vs. 498%. Total expenditures for facet joint interventions in the Medicare population increased from over $229 million in 2002 to over $511 million in 2006, with an overall increase of 123%. In 2006, there was a 26.8-fold difference in utilization of facet joint intervention services in Florida compared to the state with the lowest utilization - Hawaii. There was an annual increase of 277.3% in the utilization of facet joint interventions by general physicians, whereas a 99.5% annual increase was seen for nurse practitioners (NPs) and certified registered nurse anesthetists (CRNAs) from 2002 to 2006. Further, in Florida, 47% of facet joint interventions were performed by general physicians

  19. Systematic review of tests to identify the disc, SIJ or facet joint as the source of low back pain

    PubMed Central

    Maher, C. G.; Latimer, J.; Spindler, M. F.; McAuley, J. H.; Laslett, M.; Bogduk, N.

    2007-01-01

    Clinical practice guidelines state that the tissue source of low back pain cannot be specified in the majority of patients. However, there has been no systematic review of the accuracy of diagnostic tests used to identify the source of low back pain. The aim of this systematic review was therefore to determine the diagnostic accuracy of tests available to clinicians to identify the disc, facet joint or sacroiliac joint (SIJ) as the source of low back pain. MEDLINE, EMBASE and CINAHL were searched up to February 2006 with citation tracking of eligible studies. Eligible studies compared index tests with an appropriate reference test (discography, facet joint or SIJ blocks or medial branch blocks) in patients with low back pain. Positive likelihood ratios (+LR) > 2 or negative likelihood ratios (-LR) < 0.5 were considered informative. Forty-one studies of moderate quality were included; 28 investigated the disc, 8 the facet joint and 7 the SIJ. Various features observed on MRI (high intensity zone, endplate changes and disc degeneration) produced informative +LR (> 2) in the majority of studies increasing the probability of the disc being the low back pain source. However, heterogeneity of the data prevented pooling. +LR ranged from 1.5 to 5.9, 1.6 to 4.0, and 0.6 to 5.9 for high intensity zone, disc degeneration and endplate changes, respectively. Centralisation was the only clinical feature found to increase the likelihood of the disc as the source of pain: +LR = 2.8 (95%CI 1.4–5.3). Absence of degeneration on MRI was the only test found to reduce the likelihood of the disc as the source of pain: −LR = 0.21 (95%CI 0.12–0.35). While single manual tests of the SIJ were uninformative, their use in combination was informative with +LR of 3.2 (95%CI 2.3–4.4) and −LR of 0.29 (95%CI 0.12–0.35). None of the tests for facet joint pain were found to be informative. The results of this review demonstrate that tests do exist that change the probability of the

  20. [Concomitant diseases in primary joint hypermobility syndrome].

    PubMed

    Skoumal, Martin; Haberhauer, Günther; Mayr, Hans

    2004-10-15

    The primary joint hypermobility syndrome (pJH) is an overlap disorder of connective-tissue dysplasias, which incorporates features seen in the Marfan syndromes (MFS), Ehlers-Danlos syndromes (EDS), and osteogenesis imperfecta. Patients with pJH usually present arthralgia, back pain, soft-tissue lesions, recurrent joint dislocation, or subluxation. Extraarticular features may include, e. g., striae cutis, keratoconus, easy bruising, mitral valve prolapse, aortic incompetence, aneurysms, pneumothorax, hernia, urinary incontinence, and pelvic floor prolapse. Due to the high frequency of critical dissection and rupture, the early recognition of rare life-threatening complications such as dilatation of the aortic root and aneurysms is important. Therefore, patients (and their family members) with pJH should also be examined for life-threatening features seen in MFS and EDS. PMID:15490074

  1. Effect of changing lumbar stiffness by single facet joint dysfunction on the responsiveness of lumbar muscle spindles to vertebral movement

    PubMed Central

    Reed, William R.; Pickar, Joel G.; Long, Cynthia R.

    2014-01-01

    Objective: Individuals experiencing low back pain often present clinically with intervertebral joint dysfunction. The purpose of this study was to determine whether relative changes in stiffness at a single spinal joint alters neural responsiveness of lumbar muscle spindles to either vertebral movement or position. Methods: Muscle spindle discharge was recorded in response to 1mm L6 ramp and hold movements (0.5mm/s) in the same animal for lumbar laminectomy-only (n=23), laminectomy & L5/6 facet screw (n=19), laminectomy & L5/6 facetectomy (n=5) conditions. Mean instantaneous frequency (MIF) was calculated for the ramp-up, hold, ramp-down and post-ramp phases during each joint condition. Results: Mean MIFs were not significantly different between the laminectomy-only and the other two types of joint dysfunction for the ramp-up, hold, ramp-down, or post-ramp phases. Conclusion: Stiffness changes caused by single facet joint dysfunction failed to alter spindle responses during slow 1mm ramp and hold movements of the L6 vertebra. PMID:24932020

  2. 18F-Sodium Fluoride PET-CT Hybrid Imaging of the Lumbar Facet Joints: Tracer Uptake and Degree of Correlation to CT-graded Arthropathy

    PubMed Central

    Mabray, Marc C.; Brus-Ramer, Marcel; Behr, Spencer C.; Pampaloni, Miguel H.; Majumdar, Sharmila; Dillon, William P.; Talbott, Jason F.

    2016-01-01

    We aim to evaluate 18F-NaF uptake by facet joints with hybrid PET-CT technique. Specifically, we evaluate NaF uptake in the facet joints of the lower lumbar spine, and correlate with the morphologic grade of facet arthropathy on CT. 30 consecutive patients who underwent standard vertex to toes NaF PET-CT for re-staging of primary neoplastic disease without measurable or documented bony metastases were identified. Maximum (SUVmax) and average (SUVavg) standardized uptake values were calculated for each L3-4, L4-5, and L5-S1 facet joint (n = 180) and normalized to average uptake in the non-diseased femur. A Pathria grade (0-3) was assigned to each facet based upon the CT morphology. Spearman's rank correlation was performed for normalized SUVmax and SUVavg with Pathria grade. ANOVA was performed with Tukey-Kramer pairwise tests to evaluate differences in uptake between Pathria groups. Facet normalized SUVmax (r = 0.31, P < 0.001) and SUVavg (r = 0.28, P < 0.001) demonstrated a mild positive correlation with CT Pathria grade. There was a wide range of uptake values within each Pathria grade subgroup with statistically significant differences in uptake only between Pathria grade 3 as compared to grades 0, 1, and 2. In conclusion, NaF uptake and morphologic changes of the facet joint on CT are weakly correlated. Physiologic information provided by NaF uptake is often discrepant with structural findings on CT suggesting NaF PET may supplement conventional structural imaging for identification of pain generating facet joints. Prospective investigation into the relationship of facet joint NaF uptake with pain and response to pain interventions is warranted. PMID:27134557

  3. Soft tissue strain and facet face interaction in the lumbar intervertebral joint--Part II: Calculated results and comparison with experimental data.

    PubMed

    Tencer, A F; Mayer, T G

    1983-08-01

    A numerical simulation of soft-tissue strain and facet face interaction in the lumbar intervertebral joint under load was performed. The results, compared with a previous experimental sectioning study, showed that disk fiber strain was the main mechanism in shear resistance, except posterior shear, where the facets were main load bearing members. In axial compression, compression of the annulus was found, with a significant decrease in compressive strain resulting from annulus bulging, but no contact was found in the facet joints. The posterior ligaments, except for the facet capsules and ligamentum flavum, were found to be active only in flexion and lateral bending, while the facets and the disk both played major roles in resisting axial torsion moments. PMID:6632823

  4. Percutaneous Resolution of Lumbar Facet Joint Cysts as an Alternative Treatment to Surgery: A Meta-Analysis

    PubMed Central

    Shuang, Feng; Hou, Shu-Xun; Zhu, Jia-Liang; Ren, Dong-Feng; Cao, Zheng; Tang, Jia-Guang

    2014-01-01

    Purpose A comprehensive review of the literature in order to analyze data about the success rate of percutaneous resolution of the lumbar facet joint cysts as a conservative management strategy. Methods A systematic search for relevant articles published during 1980 to May 2014 was performed in several electronic databases by using the specific MeSH terms and keywords. Most relevant data was captured and pooled for the meta-analysis to achieve overall effect size of treatment along with 95% confidence intervals. Results 29 studies were included in the meta-analysis. Follow-up duration as mean ± sd (range) was 16±10.2 (5 days to 5.7 years). Overall the satisfactory results (after short- or long-term follow-up) were achieved in 55.8 [49.5, 62.08] % (pooled mean and 95% CI) of the 544 patients subjected to percutaneous lumbar facet joint cyst resolution procedures. 38.67 [33.3, 43.95] % of this population underwent surgery subsequently to achieve durable relief. There existed no linear relationship between the increasing average duration of follow-up period of individual studies and percent satisfaction from the percutaneous resolutions procedure. Conclusion Results shows that the percutaneous cyst resolution procedures have potential to be an alternative to surgical interventions but identification of suitable subjects requires further research. PMID:25389771

  5. Biomechanical analysis of press-extension technique on degenerative lumbar with disc herniation and staggered facet joint.

    PubMed

    Du, Hong-Gen; Liao, Sheng-Hui; Jiang, Zhong; Huang, Huan-Ming; Ning, Xi-Tao; Jiang, Neng-Yi; Pei, Jian-Wei; Huang, Qin; Wei, Hui

    2016-05-01

    This study investigates the effect of a new Chinese massage technique named "press-extension" on degenerative lumbar with disc herniation and facet joint dislocation, and provides a biomechanical explanation of this massage technique. Self-developed biomechanical software was used to establish a normal L1-S1 lumbar 3D FE model, which integrated the spine CT and MRI data-based anatomical structure. Then graphic technique is utilized to build a degenerative lumbar FE model with disc herniation and facet joint dislocation. According to the actual press-extension experiments, mechanic parameters are collected to set boundary condition for FE analysis. The result demonstrated that press-extension techniques bring the annuli fibrosi obvious induction effect, making the central nucleus pulposus forward close, increasing the pressure in front part. Study concludes that finite element modelling for lumbar spine is suitable for the analysis of press-extension technique impact on lumbar intervertebral disc biomechanics, to provide the basis for the disease mechanism of intervertebral disc herniation using press-extension technique. PMID:27275119

  6. [Burning mouth syndrome - a joint biopsychosocial approach].

    PubMed

    Arpone, Francesca; Combremont, Florian; Weber, Kerstin; Scolozzi, Paolo

    2016-02-10

    Burning mouth syndrome (BMS) is a medical condition that is often refractory to conventional diagnostic and therapeutic methods. Patients suffering from BMS can benefit from a biopsychosocial approach in a joint, medical-psychological consultation model. Such a consultation exists at Geneva University Hospitals, involving the collaboration of the maxillo-facial and oral surgery division and the division of liaison psychiatry and crisis intervention, in order to take into account the multiple factors involved in BMS onset and persistence. This article will describe BMS clinical presentation, and present an integrate approach to treat these patients. PMID:27039444

  7. Addressing the confounding role of joint hypermobility syndrome and gastrointestinal involvement in postural orthostatic tachycardia syndrome.

    PubMed

    Farmer, Adam D; Fikree, Asma; Aziz, Qasim

    2014-06-01

    Quantitative and qualitative abnormalities in visceral function have been demonstrated in postural orthostatic tachycardia syndrome. Joint hypermobility is frequently associated with both postural orthostatic tachycardia syndrome and gastrointestinal symptoms. Future studies in this area should appropriately and systematically control for the presence of joint hypermobility syndrome.

  8. Evaluation of a Robotic Assistance-System For Percutaneous Computed Tomography-Guided (CT-Guided) Facet Joint Injection: A Phantom Study

    PubMed Central

    Beyer, Lukas Philipp; Michalik, Katharina; Niessen, Christoph; da Silva, Natascha Platz Batista; Wiesinger, Isabell; Stroszczynski, Christian; Wiggermann, Philipp

    2016-01-01

    Background The aim of this study was to compare robotic assisted and freehand facet joint puncture on a phantom model in regards to time requirements and puncture accuracy. Material/Methods Forty facet joints were punctured, 20 using a robotic guidance system and 20 using a freehand procedure. Side and height of the facet joints were randomized and identical for both groups. Procedural accuracy, defined as axial and sagittal deviation, as well as the number of corrections were assessed. Procedure times for each step were documented and time requirements for pre-positioning, reconstruction, planning, and total intervention were calculated. Results Total procedure time for robotic guidance was 259±111 seconds versus 119±77 seconds for freehand procedure (p=1.0). Procedural accuracy for robotic guidance was significantly higher with 0 corrections versus 1.3 corrections for freehand procedure (p=0.02). Needle deviation in the robotics arm was 0.35±1.1 mm in the axial and 2.15±1.2 mm in the sagittal reconstruction. Conclusions Robotic assisted puncture of the facet joint allowed accurate positioning of the needle with a lower number of needle readjustments. Higher procedural accuracy was marginally offset by a slightly longer intervention time. PMID:27648509

  9. Evaluation of a Robotic Assistance-System For Percutaneous Computed Tomography-Guided (CT-Guided) Facet Joint Injection: A Phantom Study.

    PubMed

    Beyer, Lukas Philipp; Michalik, Katharina; Niessen, Christoph; Platz Batista da Silva, Natascha; Wiesinger, Isabell; Stroszczynski, Christian; Wiggermann, Philipp

    2016-09-20

    BACKGROUND The aim of this study was to compare robotic assisted and freehand facet joint puncture on a phantom model in regards to time requirements and puncture accuracy. MATERIAL AND METHODS Forty facet joints were punctured, 20 using a robotic guidance system and 20 using a freehand procedure. Side and height of the facet joints were randomized and identical for both groups. Procedural accuracy, defined as axial and sagittal deviation, as well as the number of corrections were assessed. Procedure times for each step were documented and time requirements for pre-positioning, reconstruction, planning, and total intervention were calculated. RESULTS Total procedure time for robotic guidance was 259±111 seconds versus 119±77 seconds for freehand procedure (p=1.0). Procedural accuracy for robotic guidance was significantly higher with 0 corrections versus 1.3 corrections for freehand procedure (p=0.02). Needle deviation in the robotics arm was 0.35±1.1 mm in the axial and 2.15±1.2 mm in the sagittal reconstruction. CONCLUSIONS Robotic assisted puncture of the facet joint allowed accurate positioning of the needle with a lower number of needle readjustments. Higher procedural accuracy was marginally offset by a slightly longer intervention time.

  10. Evaluation of a Robotic Assistance-System For Percutaneous Computed Tomography-Guided (CT-Guided) Facet Joint Injection: A Phantom Study.

    PubMed

    Beyer, Lukas Philipp; Michalik, Katharina; Niessen, Christoph; Platz Batista da Silva, Natascha; Wiesinger, Isabell; Stroszczynski, Christian; Wiggermann, Philipp

    2016-01-01

    BACKGROUND The aim of this study was to compare robotic assisted and freehand facet joint puncture on a phantom model in regards to time requirements and puncture accuracy. MATERIAL AND METHODS Forty facet joints were punctured, 20 using a robotic guidance system and 20 using a freehand procedure. Side and height of the facet joints were randomized and identical for both groups. Procedural accuracy, defined as axial and sagittal deviation, as well as the number of corrections were assessed. Procedure times for each step were documented and time requirements for pre-positioning, reconstruction, planning, and total intervention were calculated. RESULTS Total procedure time for robotic guidance was 259±111 seconds versus 119±77 seconds for freehand procedure (p=1.0). Procedural accuracy for robotic guidance was significantly higher with 0 corrections versus 1.3 corrections for freehand procedure (p=0.02). Needle deviation in the robotics arm was 0.35±1.1 mm in the axial and 2.15±1.2 mm in the sagittal reconstruction. CONCLUSIONS Robotic assisted puncture of the facet joint allowed accurate positioning of the needle with a lower number of needle readjustments. Higher procedural accuracy was marginally offset by a slightly longer intervention time. PMID:27648509

  11. Indian Hedgehog signaling pathway members are associated with magnetic resonance imaging manifestations and pathological scores in lumbar facet joint osteoarthritis.

    PubMed

    Shuang, Feng; Zhou, Ying; Hou, Shu-Xun; Zhu, Jia-Liang; Liu, Yan; Zhang, Chun-Li; Tang, Jia-Guang

    2015-01-01

    Indian Hedgehog (HH) has been shown to be involved in osteoarthritis (OA) in articular joints, where there is evidence that Indian HH blockade could ameliorate OA. It seems to play a prominent role in development of the intervertebral disc (IVD) and in postnatal maintenance. There is little work on IHH in the IVD. Hence the aim of the current study was to investigate the role of Indian Hedgehog in the pathology of facet joint (FJ) OA. 24 patients diagnosed with lumbar intervertebral disk herniation or degenerative spinal stenosis were included. Preoperative magnetic resonance imaging (MRI) and Osteoarthritis Research Society International (OARSI) histopathology grading system was correlated to the mRNA levels of GLI1, PTCH1, and HHIP in the FJs. The Weishaupt grading and OARSI scores showed high positive correlation (r = 0.894) (P < 0.01). MRI Weishaupt grades showed positive correlation with GLI1 (r = 0.491), PTCH1 (r = 0.444), and HHIP (r = 0.654) mRNA levels (P < 0.05 in each case). OARSI scores were also positively correlated with GLI1 (r = 0. 646), PTCH1 (r = 0. 518), and HHIP (r = 0.762) mRNA levels (P < 0.01 in each case). Cumulatively our findings indicate that Indian HH signaling is increased in OA and is perhaps a key component in OA pathogenesis and progression. PMID:25992955

  12. Indian Hedgehog signaling pathway members are associated with magnetic resonance imaging manifestations and pathological scores in lumbar facet joint osteoarthritis.

    PubMed

    Shuang, Feng; Zhou, Ying; Hou, Shu-Xun; Zhu, Jia-Liang; Liu, Yan; Zhang, Chun-Li; Tang, Jia-Guang

    2015-01-01

    Indian Hedgehog (HH) has been shown to be involved in osteoarthritis (OA) in articular joints, where there is evidence that Indian HH blockade could ameliorate OA. It seems to play a prominent role in development of the intervertebral disc (IVD) and in postnatal maintenance. There is little work on IHH in the IVD. Hence the aim of the current study was to investigate the role of Indian Hedgehog in the pathology of facet joint (FJ) OA. 24 patients diagnosed with lumbar intervertebral disk herniation or degenerative spinal stenosis were included. Preoperative magnetic resonance imaging (MRI) and Osteoarthritis Research Society International (OARSI) histopathology grading system was correlated to the mRNA levels of GLI1, PTCH1, and HHIP in the FJs. The Weishaupt grading and OARSI scores showed high positive correlation (r = 0.894) (P < 0.01). MRI Weishaupt grades showed positive correlation with GLI1 (r = 0.491), PTCH1 (r = 0.444), and HHIP (r = 0.654) mRNA levels (P < 0.05 in each case). OARSI scores were also positively correlated with GLI1 (r = 0. 646), PTCH1 (r = 0. 518), and HHIP (r = 0.762) mRNA levels (P < 0.01 in each case). Cumulatively our findings indicate that Indian HH signaling is increased in OA and is perhaps a key component in OA pathogenesis and progression.

  13. Indian Hedgehog signaling pathway members are associated with magnetic resonance imaging manifestations and pathological scores in lumbar facet joint osteoarthritis

    NASA Astrophysics Data System (ADS)

    Shuang, Feng; Zhou, Ying; Hou, Shu-Xun; Zhu, Jia-Liang; Liu, Yan; Zhang, Chun-Li; Tang, Jia-Guang

    2015-05-01

    Indian Hedgehog (HH) has been shown to be involved in osteoarthritis (OA) in articular joints, where there is evidence that Indian HH blockade could ameliorate OA. It seems to play a prominent role in development of the intervertebral disc (IVD) and in postnatal maintenance. There is little work on IHH in the IVD. Hence the aim of the current study was to investigate the role of Indian Hedgehog in the pathology of facet joint (FJ) OA. 24 patients diagnosed with lumbar intervertebral disk herniation or degenerative spinal stenosis were included. Preoperative magnetic resonance imaging (MRI) and Osteoarthritis Research Society International (OARSI) histopathology grading system was correlated to the mRNA levels of GLI1, PTCH1, and HHIP in the FJs. The Weishaupt grading and OARSI scores showed high positive correlation (r = 0.894) (P < 0.01). MRI Weishaupt grades showed positive correlation with GLI1 (r = 0.491), PTCH1 (r = 0.444), and HHIP (r = 0.654) mRNA levels (P < 0.05 in each case). OARSI scores were also positively correlated with GLI1 (r = 0. 646), PTCH1 (r = 0. 518), and HHIP (r = 0.762) mRNA levels (P < 0.01 in each case). Cumulatively our findings indicate that Indian HH signaling is increased in OA and is perhaps a key component in OA pathogenesis and progression.

  14. Generalized joint hypermobility, joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Castori, Marco; Colombi, Marina

    2015-03-01

    This issue of the American Journal of Medical Genetics Seminar Series Part C is dedicated to generalized joint hypermobility (gJHM), joint hypermobility syndrome (JHS), and Ehlers-Danlos syndrome, hypermobility type (EDS-HT). gJHM is the best known clinical manifestation of inherited defects of the connective tissue. On the other side, JHS and EDS-HT are actually considered one and the same from a clinical perspective by most practitioners and researchers (i.e., JHS/EDS-HT), and their molecular basis remains unknown. For decades, "non-syndromic" gJHM and JHS/EDS-HT have been thought to be simple clinical curiosities or an asset for the "affected" individual. In recent years, the attention on these partially overlapping phenotypes has increased, as they are now recognized risk factors for a series of non-communicable diseases and long-term disabilities. This series consists of 10 papers focused on three main topics, namely (i) assessment and differential diagnosis of children and adults with gJHM, (ii) systematic presentation of selected key non-articular manifestations of JHS/EDS-HT and actual perception of physiotherapy as the best therapeutic resource for this condition, and (iii) exploration of the available knowledge relating "congenital laxity of tissues" to various dysfunctions of the nervous system during development and adulthood. The contributors hope that this collection raises attention to this fascinating field of knowledge, which seems to have ramifications in virtually all medical disciplines.

  15. Generalized joint hypermobility, joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Castori, Marco; Colombi, Marina

    2015-03-01

    This issue of the American Journal of Medical Genetics Seminar Series Part C is dedicated to generalized joint hypermobility (gJHM), joint hypermobility syndrome (JHS), and Ehlers-Danlos syndrome, hypermobility type (EDS-HT). gJHM is the best known clinical manifestation of inherited defects of the connective tissue. On the other side, JHS and EDS-HT are actually considered one and the same from a clinical perspective by most practitioners and researchers (i.e., JHS/EDS-HT), and their molecular basis remains unknown. For decades, "non-syndromic" gJHM and JHS/EDS-HT have been thought to be simple clinical curiosities or an asset for the "affected" individual. In recent years, the attention on these partially overlapping phenotypes has increased, as they are now recognized risk factors for a series of non-communicable diseases and long-term disabilities. This series consists of 10 papers focused on three main topics, namely (i) assessment and differential diagnosis of children and adults with gJHM, (ii) systematic presentation of selected key non-articular manifestations of JHS/EDS-HT and actual perception of physiotherapy as the best therapeutic resource for this condition, and (iii) exploration of the available knowledge relating "congenital laxity of tissues" to various dysfunctions of the nervous system during development and adulthood. The contributors hope that this collection raises attention to this fascinating field of knowledge, which seems to have ramifications in virtually all medical disciplines. PMID:25821089

  16. Cervical Facet Joint Infection and Associated Epidural Abscess with Streptococcus intermedius from a Dental Infection Origin A Case Report and Review.

    PubMed

    Kaye, Ian David; Protopsaltis, Themistocles S

    2016-09-01

    Pyogenic cervical facet joint infections are rare and such infections from a dental origin are even less common. Of these few cases, none have described infection with Streptococcus intermedius as the pathogen. A 65-year-old orthopaedic surgeon complained of fevers, right-sided radiating neck pain, stiffness, swelling, erythema, and right upper extremity weakness one month after he had broken a crown over his right mandibular premolar, a continued source of pain. Imaging of the cervical spine showed a right C4-C5 facet inflammatory arthropathy and a small epidural abscess that was cultured and initially treated with intravenous antibiotics. The oral maxillofacial surgery team performed an extraction of the infected, symptomatic tooth. For continued right upper extremity weakness, the patient underwent C4-C5 laminoforaminotomy and irrigation and debridement of the right C4-C5 facet joint. After 6 weeks of intravenous antibiotics, the patient's infectious and inflammatory markers had normalized. By 4 months, he had regained full strength at his upper extremity and a painless and full range of motion of his cervical spine.Pyogenic cervical facet joint infection is very rare and potentially dangerous. A high clinical suspicion and appropriate imaging, including magnetic resonance imaging, are important for correct diagnosis. Prompt medical and surgical treatment may avert complications, and although the patient presented made a complete recovery, patients may be left with neurological compromise.

  17. Cervical Facet Joint Infection and Associated Epidural Abscess with Streptococcus intermedius from a Dental Infection Origin A Case Report and Review.

    PubMed

    Kaye, Ian David; Protopsaltis, Themistocles S

    2016-09-01

    Pyogenic cervical facet joint infections are rare and such infections from a dental origin are even less common. Of these few cases, none have described infection with Streptococcus intermedius as the pathogen. A 65-year-old orthopaedic surgeon complained of fevers, right-sided radiating neck pain, stiffness, swelling, erythema, and right upper extremity weakness one month after he had broken a crown over his right mandibular premolar, a continued source of pain. Imaging of the cervical spine showed a right C4-C5 facet inflammatory arthropathy and a small epidural abscess that was cultured and initially treated with intravenous antibiotics. The oral maxillofacial surgery team performed an extraction of the infected, symptomatic tooth. For continued right upper extremity weakness, the patient underwent C4-C5 laminoforaminotomy and irrigation and debridement of the right C4-C5 facet joint. After 6 weeks of intravenous antibiotics, the patient's infectious and inflammatory markers had normalized. By 4 months, he had regained full strength at his upper extremity and a painless and full range of motion of his cervical spine.Pyogenic cervical facet joint infection is very rare and potentially dangerous. A high clinical suspicion and appropriate imaging, including magnetic resonance imaging, are important for correct diagnosis. Prompt medical and surgical treatment may avert complications, and although the patient presented made a complete recovery, patients may be left with neurological compromise. PMID:27620549

  18. Differences Regarding Branded HA in Italy, Part 2: Data from Clinical Studies on Knee, Hip, Shoulder, Ankle, Temporomandibular Joint, Vertebral Facets, and Carpometacarpal Joint

    PubMed Central

    Migliore, A.; Bizzi, E.; De Lucia, O.; Delle Sedie, A.; Tropea, S.; Bentivegna, M.; Mahmoud, A.; Foti, C.

    2016-01-01

    OBJECTIVES The aim of the current study is to collect scientific data on all branded hyaluronic acid (HA) products in Italy that are in use for intra-articular (IA) injection in osteoarthritis (OA) compared with that reported in the leaflet. METHODS An extensive literature research was performed for all articles reporting data on the IA use of HA in OA. Selected studies were taken into consideration only if they are related to products based on HAs that are currently marketed in Italy with the specific joint indication for IA use in patients affected by OA. RESULTS Sixty-two HA products are marketed in Italy: 30 products are indicated for the knee but only 8 were proved with some efficacy; 9 products were effective for the hip but only 6 had hip indication; 7 products proved to be effective for the shoulder but only 3 had the indication; 5 products proved effective for the ankle but only one had the indication; 6 products were effective for the temporomandibular joint but only 2 had the indication; only 2 proved effective for vertebral facet joints but only 1 had the indication; and 5 products proved effective for the carpometacarpal joint but only 2 had the indication. CONCLUSIONS There are only a few products with some evidences, while the majority of products remain without proof. Clinicians and regulators should request postmarketing studies from pharmaceuticals to corroborate with that reported in the leaflet and to gather more data, allowing the clinicians to choose the adequate product for the patient. PMID:27279754

  19. 3D visualization of the lumbar facet joint after degeneration using propagation phase contrast micro-tomography

    PubMed Central

    Cao, Yong; Zhang, Yi; Yin, Xianzheng; Lu, Hongbin; Hu, Jianzhong; Duan, Chunyue

    2016-01-01

    Lumbar facet joint (LFJ) degeneration is believed to be an important cause of low back pain (LBP). Identifying the morphological changes of the LFJ in the degeneration process at a high-resolution level could be meaningful for our better understanding of the possible mechanisms underlying this process. In the present study, we determined the 3D morphology of the LFJ using propagation phase contrast micro-tomography (PPCT) in rats to assess the subtle changes that occur during the degeneration process. PPCT provides vivid 3D images of micromorphological changes in the LFJ during its degeneration process, and the changes in the subchondral bone occurred earlier than in the cartilage during the early stage of degeneration of the LFJ. The delineation of this alteration was similar to that with the histological method. Our findings demonstrated that PPCT could serve as a valuable tool for 3D visualization of the morphology of the LFJ by providing comprehensive information about the cartilage and the underlying subchondral bone and their changes during degeneration processes. It might also have great potential for providing effective diagnostic tools to track changes in the cartilage and to evaluate the effects of therapeutic interventions for LFJ degeneration in preclinical studies. PMID:26907889

  20. Isolated septic facet joint arthritis as a rare cause of acute and chronic low back pain – a case report and literature review

    PubMed Central

    Klekot, Dominika; Zimny, Anna; Czapiga, Bogdan; Sąsiadek, Marek

    2012-01-01

    Summary Background: The most common cause of low back pain is degenerative disease of the intervertebral disc and other structures of the lumbar spine. However, in some cases other less frequent causes of such pain can be seen, for example septic facet joint arthritis. Until now, only 40 cases of such inflammatory changes within the spine have been reported in the literature. The disease is probably underestimated due to improper diagnostic pathway. Case Report: The authors describe a case of a 53-year-old woman who was repeatedly hospitalized during a five-month period because of an acute, severe low back pain, with sphincter dysfunction, partially resembling sciatic symptoms. Physical examinations revealed also focal tenderness in the area of the lumbar spine. Inflammatory markers (ESR – erythrocyte sedimentation rate, CRP – C-reactive protein) were elevated. Conservative analgetic treatment brought only partial and temporary relief of the pain and symptoms. The final accurate diagnosis of isolated septic facet joint arthritis at the level of L5/S1 was established after several months from the onset of the first symptoms, after performing various imaging examinations, including bone scintigraphy as well as CT and MRI of the lumbosacral spine. The patient fully recovered after antibiotic therapy and surgery, which was proven in several follow-up examinations showing no relevant pathology of the lumbar spine. The authors broadly describe the etiology and clinical symptoms of the septic facet joint arthritis as well as the significant role of imaging methods, especially MRI, in diagnostic process. The authors also discuss currently available treatment options, both conservative and surgical. Conclusions: The diagnostic procedure of septic facet joint arthritis requires several steps to be taken. Establishing a correct diagnosis may be difficult, that is why it is important to remember about rare causes of low back pain and to perform detailed physical

  1. Limited joint mobility syndrome in diabetes mellitus: A minireview

    PubMed Central

    Gerrits, Esther G; Landman, Gijs W; Nijenhuis-Rosien, Leonie; Bilo, Henk J

    2015-01-01

    Limited joint mobility syndrome (LJMS) or diabetic cheiroarthropathy is a long term complication of diabetes mellitus. The diagnosis of LJMS is based on clinical features: progression of painless stiffness of hands and fingers, fixed flexion contractures of the small hand and foot joints, impairment of fine motion and impaired grip strength in the hands. As the syndrome progresses, it can also affect other joints. It is important to properly diagnose such a complication as LJMS. Moreover, it is important to diagnose LJMS because it is known that the presence of LJMS is associated with micro- and macrovascular complications of diabetes. Due to the lack of curative treatment options, the suggested method to prevent or decelerate the development of LJMS is improving or maintaining good glycemic control. Daily stretching excercises of joints aim to prevent or delay progression of joint stiffness, may reduce the risk of inadvertent falls and will add to maintain quality of life. PMID:26265997

  2. Clinical effects of computed tomography-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs.

    PubMed

    Liotta, Annalisa P; Girod, Maud; Peeters, Dominique; Sandersen, Charlotte; Couvreur, Thierry; Bolen, Géraldine

    2016-10-01

    OBJECTIVE To determine clinical effects of CT-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs. ANIMALS 15 healthy Beagles. PROCEDURES Dogs were randomly assigned to 3 groups (5 dogs/group) and received a single CT-guided lumbosacral facet joint, transforaminal epidural, or translaminar epidural injection of methylprednisolone acetate (0.1 mg/kg). Contrast medium was injected prior to injection of methylprednisolone to verify needle placement. Neurologic examinations were performed 1, 3, 7, and 10 days after the injection. In dogs with neurologic abnormalities, a final neurologic examination was performed 24 days after the procedure. RESULTS Methylprednisolone injections were successfully performed in 14 of the 15 dogs. In 1 dog, vascular puncture occurred, and the methylprednisolone injection was not performed. No major or minor complications were identified during or immediately after the procedure, other than mild transient hyperthermia. During follow-up neurologic examinations, no motor, sensory, or postural deficits were identified, other than mild alterations in the patellar, withdrawal, cranial tibial, and perineal reflexes in some dogs. Overall, altered reflexes were observed in 11 of the 14 dogs, during 27 of 65 neurologic examinations. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that CT-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate were associated with few complications in healthy dogs. However, the number of dogs evaluated was small, and additional studies are needed to assess clinical efficacy and safety of these procedures. PMID:27668585

  3. Evaluation of lower limb disability in joint hypermobility syndrome.

    PubMed

    Celletti, Claudia; Castori, Marco; Grammatico, Paola; Camerota, Filippo

    2012-08-01

    The aim of this study is to evaluate degree and possible major determinants of lower limb disability in joint hypermobility syndrome. Forty patients with joint hypermobility syndrome were studied. Lower limb function was evaluated with the lower limb functional scale (LEFS). Intensity of pain was estimated by the numeric rating scale. Rough results were compared with previously published data for osteoarthritis patients. Within the studied population, comparisons were performed by age, sex, numeric rating scale and Beighton scores. In joint hypermobility syndrome, LEFS score was similar to osteoarthritis, but in the former, comparable values were observed with a ~10 year earlier onset. LEFS scores resulted significantly related to age, pain intensity and Beighton score. No correlation with sex was observed. This study demonstrated that, in joint hypermobility syndrome, disability of lower limbs is remarkable and related to the increase in pain and age and to the decrease in residual joint hypermobility. These preliminary results may be relevant for the identification of more efficient and tailored treatment programs. PMID:21792643

  4. Joint hypermobility syndrome: problems that require psychological intervention.

    PubMed

    Baeza-Velasco, C; Gély-Nargeot, M C; Bulbena Vilarrasa, A; Bravo, J F

    2011-09-01

    Joint hypermobility syndrome (JHS), also known as Ehlers-Danlos III, is an inherited disorder of connective tissue, characterised by an exceptional increase in the joint's mobility and the presence of musculoskeletal and other symptoms. It is a benign syndrome if compared with the other types of Ehlers-Danlos, but it can become disabling particularly because it is a significant source of pain and distress. The purpose of this work is to describe some common problems in JHS that render psychological intervention in their overall management relevant. Chronic pain, associated psychopathological factors such as anxiety, depression and somatosensory amplification, and problems arising from a lack of recognition and knowledge of the syndrome, are frequent among those affected, having a negative impact on their quality of life. We emphasise the relevance of addressing JHS from a biopsychosocial approach. PMID:21373784

  5. Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis: An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium

    PubMed Central

    Samartzis, Dino; Cheung, Jason Pui Yin; Rajasekaran, Shanmuganathan; Kawaguchi, Yoshiharu; Acharya, Shankar; Kawakami, Mamoru; Satoh, Shigenobu; Chen, Wen-Jer; Park, Chun-Kun; Lee, Chong-Suh; Foocharoen, Thanit; Nagashima, Hideki; Kuh, Sunguk; Zheng, Zhaomin; Condor, Richard; Ito, Manabu; Iwasaki, Motoki; Jeong, Je Hoon; Luk, Keith D. K.; Prijambodo, Bambang; Rege, Amol; Jahng, Tae-Ahn; Luo, Zhuojing; Tassanawipas, Warat; Acharya, Narayana; Pokharel, Rohit; Shen, Yong; Ito, Takui; Zhang, Zhihai; Aithala P, Janardhana; Kumar, Gomatam Vijay; Jabir, Rahyussalim Ahmad; Basu, Saumyajit; Li, Baojun; Moudgil, Vishal; Goss, Ben; Sham, Phoebe; Williams, Richard

    2015-01-01

    Study Design  An international, multicenter cross-sectional image-based study performed in 33 institutions in the Asia Pacific region. Objective  The study addressed the role of facet joint angulation and tropism in relation to L4–L5 degenerative spondylolisthesis (DS). Methods  The study included 349 patients (63% females; mean age: 61.8 years) with single-level DS; 82 had no L4–L5 DS (group A) and 267 had L4–L5 DS (group B). Axial computed tomography and magnetic resonance imaging were utilized to assess facet joint angulations and tropism (i.e., asymmetry between facet joint angulations) between groups. Results  There was a statistically significant difference between group A (left mean: 46.1 degrees; right mean: 48.2 degrees) and group B (left mean: 55.4 degrees; right mean: 57.5 degrees) in relation to bilateral L4–L5 facet joint angulations (p < 0.001). The mean bilateral angulation difference was 7.4 and 9.6 degrees in groups A and B, respectively (p = 0.025). A critical value of 58 degrees or greater significantly increased the likelihood of DS if unilateral (adjusted OR: 2.5; 95% CI: 1.2 to 5.5; p = 0.021) or bilateral facets (adjusted OR: 5.9; 95% CI: 2.7 to 13.2; p < 0.001) were involved. Facet joint tropism was found to be relevant between 16 and 24 degrees angulation difference (adjusted OR: 5.6; 95% CI: 1.2 to 26.1; p = 0.027). Conclusions  In one of the largest studies assessing facet joint orientation in patients with DS, greater sagittal facet joint angulation was associated with L4-L5 DS, with a critical value of 58 degrees or greater increasing the likelihood of the condition for unilateral and bilateral facet joint involvement. Specific facet joint tropism categories were noted to be associated with DS. PMID:27433424

  6. Reduction of radiation dose during facet joint injection using the new image guidance system SabreSource™: a prospective study in 60 patients

    PubMed Central

    Proschek, Dirk; Kafchitsas, K.; Rauschmann, M. A.; Kurth, A. A.; Vogl, T. J.

    2008-01-01

    Interventional procedures are associated with high radiation doses for both patients and surgeons. To reduce the risk from ionizing radiation, it is essential to minimize radiation dose. This prospective study was performed to evaluate the effectiveness in reducing radiation dose during facet joint injection in the lumbar spine and to evaluate the feasibility and possibilities of the new real time image guidance system SabreSource™. A total of 60 patients, treated with a standardized injection therapy of the facet joints L4–L5 or L5–S1, were included in this study. A total of 30 patients were treated by fluoroscopy guidance alone, the following 30 patients were treated using the new SabreSource™ system. Thus a total of 120 injections to the facet joints were performed. Pain, according to the visual analogue scale (VAS), was documented before and 6 h after the intervention. Radiation dose, time of radiation and the number of exposures needed to place the needle were recorded. No significant differences concerning age (mean age 60.5 years, range 51–69), body mass index (mean BMI 26.2, range 22.2–29.9) and preoperative pain (VAS 7.9, range 6–10) were found between the two groups. There was no difference in pain reduction between the two groups (60 vs. 61.5%; P = 0.001) but the radiation dose was significantly smaller with the new SabreSource™ system (reduction of radiation dose 32.7%, P = 0.01; reduction of mean entrance surface dose 32.3%, P = 0.01). The SabreSource™ System significantly reduced the radiation dose received during the injection therapy of the lumbar facet joints. With minimal effort for the setup at the beginning of a session, the system is easy to handle and can be helpful for other injection therapies (e.g. nerve root block therapies). PMID:19082641

  7. An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific: A Study from the AOSpine Asia Pacific Research Collaboration Consortium

    PubMed Central

    Williams, Richard; Cheung, Jason Pui Yin; Goss, Ben; Rajasekaran, Shanmuganathan; Kawaguchi, Yoshiharu; Acharya, Shankar; Kawakami, Mamoru; Satoh, Shigenobu; Chen, Wen-Jer; Park, Chun-Kun; Lee, Chong-Suh; Foocharoen, Thanit; Nagashima, Hideki; Kuh, Sunguk; Zheng, Zhaomin; Condor, Richard; Ito, Manabu; Iwasaki, Motoki; Jeong, Je Hoon; Luk, Keith D. K.; Prijambodo, Bambang; Rege, Amol; Jahng, Tae-Ahn; Luo, Zhuojing; Tassanawipas, Warat; Acharya, Narayana; Pokharel, Rohit; Shen, Yong; Ito, Takui; Zhang, Zhihai; Aithala P, Janardhana; Kumar, Gomatam Vijay; Jabir, Rahyussalim Ahmad; Basu, Saumyajit; Li, Baojun; Moudgil, Vishal; Sham, Phoebe; Samartzis, Dino

    2015-01-01

    Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3–S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64% males, 36% females). The mean BMI was 25.6 kg/m2. The level of DS was most prevalent at L4–L5 (74.7%). There were 28.8% Indian, 28.6% Japanese, 18.1% Chinese, 8.6% Korean, 6.5% Thai, 4.9% Caucasian, 2.7% Filipino, and 1.9% Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3–L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5–S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in

  8. An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific: A Study from the AOSpine Asia Pacific Research Collaboration Consortium.

    PubMed

    Williams, Richard; Cheung, Jason Pui Yin; Goss, Ben; Rajasekaran, Shanmuganathan; Kawaguchi, Yoshiharu; Acharya, Shankar; Kawakami, Mamoru; Satoh, Shigenobu; Chen, Wen-Jer; Park, Chun-Kun; Lee, Chong-Suh; Foocharoen, Thanit; Nagashima, Hideki; Kuh, Sunguk; Zheng, Zhaomin; Condor, Richard; Ito, Manabu; Iwasaki, Motoki; Jeong, Je Hoon; Luk, Keith D K; Prijambodo, Bambang; Rege, Amol; Jahng, Tae-Ahn; Luo, Zhuojing; Tassanawipas, Warat; Acharya, Narayana; Pokharel, Rohit; Shen, Yong; Ito, Takui; Zhang, Zhihai; Aithala P, Janardhana; Kumar, Gomatam Vijay; Jabir, Rahyussalim Ahmad; Basu, Saumyajit; Li, Baojun; Moudgil, Vishal; Sham, Phoebe; Samartzis, Dino

    2016-02-01

    Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3-S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64% males, 36% females). The mean BMI was 25.6 kg/m(2). The level of DS was most prevalent at L4-L5 (74.7%). There were 28.8% Indian, 28.6% Japanese, 18.1% Chinese, 8.6% Korean, 6.5% Thai, 4.9% Caucasian, 2.7% Filipino, and 1.9% Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3-L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5-S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in facet

  9. An International Multicenter Study Assessing the Role of Ethnicity on Variation of Lumbar Facet Joint Orientation and the Occurrence of Degenerative Spondylolisthesis in Asia Pacific: A Study from the AOSpine Asia Pacific Research Collaboration Consortium.

    PubMed

    Williams, Richard; Cheung, Jason Pui Yin; Goss, Ben; Rajasekaran, Shanmuganathan; Kawaguchi, Yoshiharu; Acharya, Shankar; Kawakami, Mamoru; Satoh, Shigenobu; Chen, Wen-Jer; Park, Chun-Kun; Lee, Chong-Suh; Foocharoen, Thanit; Nagashima, Hideki; Kuh, Sunguk; Zheng, Zhaomin; Condor, Richard; Ito, Manabu; Iwasaki, Motoki; Jeong, Je Hoon; Luk, Keith D K; Prijambodo, Bambang; Rege, Amol; Jahng, Tae-Ahn; Luo, Zhuojing; Tassanawipas, Warat; Acharya, Narayana; Pokharel, Rohit; Shen, Yong; Ito, Takui; Zhang, Zhihai; Aithala P, Janardhana; Kumar, Gomatam Vijay; Jabir, Rahyussalim Ahmad; Basu, Saumyajit; Li, Baojun; Moudgil, Vishal; Sham, Phoebe; Samartzis, Dino

    2016-02-01

    Study Design A multinational, multiethnic, cross-sectional image-based study was performed in 33 institutions, representing 10 countries, which were part of the AOSpine Asia Pacific Research Collaboration Consortium. Objective Lumbar facet joint orientation has been reported to be associated with the development of degenerative spondylolisthesis (DS). The role of ethnicity regarding facet joint orientation remains uncertain. As such, the following study was performed across a wide-ranging population base to assess the role of ethnicity in facet joint orientation in patients with DS in the Asia Pacific region. Methods Lateral standing X-rays and axial magnetic resonance imaging scans were obtained for patients with lumbar DS. The DS parameters and facet joint angulations were assessed from L3-S1. Sex, age, body mass index (BMI), and ethnicity were also noted. Results The study included 371 patients with known ethnic origin (mean age: 62.0 years; 64% males, 36% females). The mean BMI was 25.6 kg/m(2). The level of DS was most prevalent at L4-L5 (74.7%). There were 28.8% Indian, 28.6% Japanese, 18.1% Chinese, 8.6% Korean, 6.5% Thai, 4.9% Caucasian, 2.7% Filipino, and 1.9% Malay patients. Variations in facet joint angulations were noted from L3 to S1 and between patients with and without DS (p < 0.05). No differences were noted with regards to sex and overall BMI to facet joint angulations (p > 0.05); however, increasing age was found to increase the degree of angulation throughout the lumbar spine (p < 0.05). Accounting for age and the presence or absence of DS at each level, no statistically significant differences between ethnicity and degree of facet joint angulations from L3-L5 were noted (p > 0.05). Ethnic variations were noted in non-DS L5-S1 facet joint angulations, predominantly between Caucasian, Chinese, and Indian ethnicities (p < 0.05). Conclusions This study is the first to suggest that ethnicity may not play a role in facet

  10. Relationship between Fatigue and Gait Abnormality in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type

    ERIC Educational Resources Information Center

    Celletti, Claudia; Galli, Manuela; Cimolin, Veronica; Castori, Marco; Albertini, Giorgio; Camerota, Filippo

    2012-01-01

    Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterised by joint hypermobility, skin hyperextensibility and tissue fragility. It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom. The…

  11. Progressive hip joint subluxation in Saul-Wilson syndrome.

    PubMed

    Chinen, Yasutsugu; Kaneshi, Takuya; Kamiya, Takeshi; Hata, Kenichiro; Nishimura, Gen; Kaname, Tadashi

    2015-11-01

    Saul-Wilson syndrome (SWS) is a rare congenital skeletal syndrome characterized by postnatal onset of short stature, relative microcephaly, frontal bossing, prominent eyes with shallow orbits, midface hypoplasia, cataract, and generalized skeletal changes, including spondylar dysplasia, overtubulation of the long bones with metaphyseal flaring and megaepiphyses, coxa valga, elbow deformity, and brachydactyly. We describe a boy with the overall clinical and radiological features fitting the characteristics of SWS, although cataract, elbow deformity, and overt brachydactyly were not seen. He presented with painful hip joint due to hip subluxation in late childhood, which exacerbated with age and ultimately, required surgical intervention. Awareness of this orthopedic complication in SWS is essential in the management of patients with SWS. PMID:26239279

  12. Management of Temporomandibular Joint Reankylosis in Syndromic Patients Corrected with Joint Prostheses: Surgical and Rehabilitation Protocols

    PubMed Central

    Clauser, Luigi C.; Consorti, Giuseppe; Elia, Giovanni; Tieghi, Riccardo; Galiè, Manlio

    2013-01-01

    Temporomandibular joint ankylosis (TMJA) is a severe disorder described as an intracapsular union of the disc-condyle complex to the temporal articular surface with bony fusion. The management of this disability is challenging and rarely based on surgical and rehabilitation protocols. We describe the treatment in two young adults affected by Goldenhar syndrome and Pierre Robin sequence with reankylosis after previous surgical treatments. There are three main surgical procedures for the treatment of TMJA: gap arthroplasty, interpositional arthroplasty, and joint reconstruction. Various authors have described reankylosis as a frequent event after treatment. Treatment failure could be associated with surgical errors and/or inadequate intensive postoperative physiotherapy. Surgical treatment should be individually tailored and adequate postoperative physiotherapy protocol is mandatory for success. PMID:24624260

  13. Neurodevelopmental attributes of joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type: Update and perspectives.

    PubMed

    Ghibellini, Giulia; Brancati, Francesco; Castori, Marco

    2015-03-01

    In the last decade, increasing attention has been devoted to the extra-articular and extra-cutaneous manifestations of joint hypermobility syndrome, also termed Ehlers-Danlos syndrome, hypermobility type (i.e., JHS/EDS-HT). Despite the fact that the current diagnostic criteria for both disorders remain focused on joint hypermobility, musculoskeletal pain and skin changes, medical practice and research have started investigating a wide spectrum of visceral, neurological and developmental complications, which represent major burdens for affected individuals. In particular, children with generalized joint hypermobility often present with various neurodevelopmental issues and can be referred for neurological consultation. It is common that investigations in these patients yield negative or inconsistent results, eventually leading to the exclusion of any structural neurological or muscle disorder. In the context of specialized clinics for connective tissue disorders, a clear relationship between generalized joint hypermobility and a characteristic neurodevelopmental profile affecting coordination is emerging. The clinical features of these patients tend to overlap with those of developmental coordination disorder and can be associated with learning and other disabilities. Physical and psychological consequences of these additional difficulties add to the chief manifestations of the pre-existing connective tissue disorder, affecting the well-being and development of children and their families. In this review, particular attention is devoted to the nature of the link between joint hypermobility, coordination difficulties and neurodevelopmental issues in children. Presumed pathogenesis and management issues are explored in order to attract more attention on this association and nurture future clinical research. PMID:25654988

  14. Neurodevelopmental attributes of joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type: Update and perspectives.

    PubMed

    Ghibellini, Giulia; Brancati, Francesco; Castori, Marco

    2015-03-01

    In the last decade, increasing attention has been devoted to the extra-articular and extra-cutaneous manifestations of joint hypermobility syndrome, also termed Ehlers-Danlos syndrome, hypermobility type (i.e., JHS/EDS-HT). Despite the fact that the current diagnostic criteria for both disorders remain focused on joint hypermobility, musculoskeletal pain and skin changes, medical practice and research have started investigating a wide spectrum of visceral, neurological and developmental complications, which represent major burdens for affected individuals. In particular, children with generalized joint hypermobility often present with various neurodevelopmental issues and can be referred for neurological consultation. It is common that investigations in these patients yield negative or inconsistent results, eventually leading to the exclusion of any structural neurological or muscle disorder. In the context of specialized clinics for connective tissue disorders, a clear relationship between generalized joint hypermobility and a characteristic neurodevelopmental profile affecting coordination is emerging. The clinical features of these patients tend to overlap with those of developmental coordination disorder and can be associated with learning and other disabilities. Physical and psychological consequences of these additional difficulties add to the chief manifestations of the pre-existing connective tissue disorder, affecting the well-being and development of children and their families. In this review, particular attention is devoted to the nature of the link between joint hypermobility, coordination difficulties and neurodevelopmental issues in children. Presumed pathogenesis and management issues are explored in order to attract more attention on this association and nurture future clinical research.

  15. Difficulty eating and significant weight loss in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Baeza-Velasco, Carolina; Van den Bossche, Thomas; Grossin, Daniel; Hamonet, Claude

    2016-06-01

    Joint Hypermobility Syndrome, also known as Ehlers-Danlos Syndrome Hypermobility Type (JHS/EDS-HT), is a heritable disorder of connective tissue, common but poorly known by the medical community. Although generalized joint hypermobility and fragility of tissues have been described as core features, recent research highlights the multisystemic nature of JHS/EDS-HT, which presents with a wide range of articular and extra-articular symptoms. Among these, gastrointestinal problems, temporomandibular disorders, and smell and taste abnormalities are common among those affected, having significant implications for eating. The present work reviews the literature linking JHS/EDS-HT and eating problems. Two illustrative case reports, in which JHS/EDS-HT manifestations contribute to developing and maintaining disturbed eating behaviors and significant weight loss, are presented.

  16. Difficulty eating and significant weight loss in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Baeza-Velasco, Carolina; Van den Bossche, Thomas; Grossin, Daniel; Hamonet, Claude

    2016-06-01

    Joint Hypermobility Syndrome, also known as Ehlers-Danlos Syndrome Hypermobility Type (JHS/EDS-HT), is a heritable disorder of connective tissue, common but poorly known by the medical community. Although generalized joint hypermobility and fragility of tissues have been described as core features, recent research highlights the multisystemic nature of JHS/EDS-HT, which presents with a wide range of articular and extra-articular symptoms. Among these, gastrointestinal problems, temporomandibular disorders, and smell and taste abnormalities are common among those affected, having significant implications for eating. The present work reviews the literature linking JHS/EDS-HT and eating problems. Two illustrative case reports, in which JHS/EDS-HT manifestations contribute to developing and maintaining disturbed eating behaviors and significant weight loss, are presented. PMID:26506923

  17. Parallel Syndromes: Two Dimensions of Narcissism and the Facets of Psychopathic Personality in Criminally-Involved Individuals

    PubMed Central

    2012-01-01

    Little research has examined different dimensions of narcissism that may parallel psychopathy facets in criminally-involved individuals. The present study examined the pattern of relationships between grandiose and vulnerable narcissism, assessed using the Narcissistic Personality Inventory-16 and the Hypersensitive Narcissism Scale, respectively, and the four facets of psychopathy (interpersonal, affective, lifestyle, and antisocial) assessed via the Psychopathy Checklist: Screening Version (PCL:SV). As predicted, grandiose and vulnerable narcissism showed differential relationships to psychopathy facets, with grandiose narcissism relating positively to the interpersonal facet of psychopathy and vulnerable narcissism relating positively to the lifestyle facet of psychopathy. Paralleling existing psychopathy research, vulnerable narcissism showed stronger associations than grandiose narcissism to 1) other forms of psychopathology, including internalizing and substance use disorders, and 2) self- and other-directed aggression, measured using the Life History of Aggression and the Forms of Aggression Questionnaire. Grandiose narcissism was nonetheless associated with social dysfunction marked by a manipulative and deceitful interpersonal style and unprovoked aggression. Potentially important implications for uncovering etiological pathways and developing treatment interventions for these disorders in externalizing adults are discussed. PMID:22448731

  18. Torsional syndromes about the knee joint in classical ballet

    PubMed Central

    Burkett, Donald G.; Kinsman, John G.

    1982-01-01

    Dance-related pain of the lower limb is often treated symptomatically, without consideration of the chronic strains placed on the joints due to improper technique and alignment. Three pathomechanical syndromes of the knee which produce knee, ankle and foot pain are described. Clinical therapeutic approaches are proposed which emphasize the biomechanical nature of the etiology. Much information in regards to the basis of dance-related pain need be elicited before the pain-producing phenomena and its treatment can be definitively described. This paper makes no attempt to outline proper ballet technique but rather to make the chiropractor aware that insufficiencies in dance technique can and do lead to problems in the dancer. ImagesFigure 1aFigure 1bFigure 2aFigure 2bFigure 5aFigure 5bFigure 6Figure 7Figures 7c-7d

  19. Correlations Between General Joint Hypermobility and Joint Hypermobility Syndrome and Injury in Contemporary Dance Students.

    PubMed

    Ruemper, Alia; Watkins, Katherine

    2012-12-01

    The first objective of this study was to ascertain the prevalence of general joint hypermobility (GJH) and joint hypermobility syndrome (JHS) in BA Dance Theatre 1st and 3rd year students at a contemporary dance conservatory. The second objective was to determine the statistical correlation between GJH, JHS, and injury in this population. A total of 85 (female, N = 78; male, N = 7) contemporary dance students participated in the study. The Beighton score (with a forward flexion test modification) was used to determine GJH, and the Brighton criteria were used to verify JHS. Participants completed a self-reported injury questionnaire that included type of injury (physical complaint, medical diagnosis, or time-loss) and injury frequency. Statistical analysis (Pearson correlation) was used to correlate GJH, JHS, and frequency-of-injury scores. Overall, 69% of the students were found to have GJH, and 33% had JHS. A statistical correlation of r = + 0.331 (p < 0.01) was found between JHS and injury. No significant correlation was found between GJH and injury. This is the first study to look at these correlations in contemporary dance students and suggests that screening programs should include the Brighton criteria to identify JHS in these dancers. Subsequent injury tracking and injury prevention programs would then provide data for further research in this area.

  20. The effectiveness of ridetherapy in children with benign joint hypermobility syndrome during articulatory changes in the knee joint.

    PubMed

    Mosulishvili, T; Loria, M

    2013-02-01

    Taking into account the biomechanical peculiarities of ridetherapy, the specific methodology of ridetherapy developed by us is given in this paper, also the data of treatment have been studied in the dynamics. Based on the results obtained the reliable advantage of ridetherapy method is determined as compared with therapeutic exercises. It has been established that in children with benign joint hypermobility syndrome during articulatory changes in the knee the use of ridetherapy provides an increase in muscle strength, to a certain degree their hypertrophy, the development of joint-muscular perception, the increase of proprioreception, the minimizing of excessive joint movement, the antinociceptive effect and the avoidance of secondary developed complications.

  1. The effectiveness of ridetherapy in children with benign joint hypermobility syndrome during articulatory changes in the knee joint.

    PubMed

    Mosulishvili, T; Loria, M

    2013-02-01

    Taking into account the biomechanical peculiarities of ridetherapy, the specific methodology of ridetherapy developed by us is given in this paper, also the data of treatment have been studied in the dynamics. Based on the results obtained the reliable advantage of ridetherapy method is determined as compared with therapeutic exercises. It has been established that in children with benign joint hypermobility syndrome during articulatory changes in the knee the use of ridetherapy provides an increase in muscle strength, to a certain degree their hypertrophy, the development of joint-muscular perception, the increase of proprioreception, the minimizing of excessive joint movement, the antinociceptive effect and the avoidance of secondary developed complications. PMID:23482367

  2. A new syndrome of short stature, joint limitation and muscle hypertrophy.

    PubMed

    Soljak, M A; Aftimos, S; Gluckman, P D

    1983-06-01

    A further case is presented of a new growth deficiency syndrome first reported by Myre et al. in 1981. The major clinical features are mental retardation, growth deficiency, muscular hypertrophy, joint limitation and abnormal skeletal radiography. PMID:6684009

  3. Gastrointestinal and nutritional issues in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Castori, Marco; Morlino, Silvia; Pascolini, Giulia; Blundo, Carlo; Grammatico, Paola

    2015-03-01

    Gastrointestinal involvement is a well known complication of Ehlers-Danlos syndromes (EDSs), mainly in form of abdominal emergencies due to intestinal/abdominal vessels rupture in vascular EDS. In the last decade, a growing number of works investigated the relationship between a wide spectrum of chronic gastrointestinal complaints and various EDS forms, among which the hypermobility type (a.k.a. joint hypermobility syndrome; JHS/EDS-HT) was the most studied. The emerging findings depict a major role for gastrointestinal involvement in the health status and, consequently, management of JHS/EDS-HT patients. Nevertheless, fragmentation of knowledge limits its impact on practice within the boundaries of highly specialized clinics. In this paper, literature review on gastrointestinal manifestations in JHS/EDS-HT was carried out and identified papers categorized as (i) case-control/cohort studies associating (apparently non-syndromic) joint hypermobility and gastrointestinal involvement, (ii) case-control/cohort studies associating JHS/EDS-HT and gastrointestinal involvement, (iii) case reports/series on various gastrointestinal complications in (presumed) JHS/EDS-HT, and (iv) studies reporting gastrointestinal features in heterogeneous EDS patients' cohorts. Gastrointestinal manifestations of JHS/EDS-HT were organized and discussed in two categories, including structural anomalies (i.e., abdominal/diaphragmatic hernias, internal organ/pelvic prolapses, intestinal intussusceptions) and functional features (i.e., dysphagia, gastro-esophageal reflux, dyspepsia, recurrent abdominal pain, constipation/diarrhea), with emphasis on practice and future implications. In the second part of this paper, a summary of possible nutritional interventions in JHS/EDS-HT was presented. Supplementation strategies were borrowed from data available for general population with minor modifications in the light of recent discoveries in the pathogenesis of selected JHS/EDS-HT features.

  4. Gastrointestinal and nutritional issues in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Castori, Marco; Morlino, Silvia; Pascolini, Giulia; Blundo, Carlo; Grammatico, Paola

    2015-03-01

    Gastrointestinal involvement is a well known complication of Ehlers-Danlos syndromes (EDSs), mainly in form of abdominal emergencies due to intestinal/abdominal vessels rupture in vascular EDS. In the last decade, a growing number of works investigated the relationship between a wide spectrum of chronic gastrointestinal complaints and various EDS forms, among which the hypermobility type (a.k.a. joint hypermobility syndrome; JHS/EDS-HT) was the most studied. The emerging findings depict a major role for gastrointestinal involvement in the health status and, consequently, management of JHS/EDS-HT patients. Nevertheless, fragmentation of knowledge limits its impact on practice within the boundaries of highly specialized clinics. In this paper, literature review on gastrointestinal manifestations in JHS/EDS-HT was carried out and identified papers categorized as (i) case-control/cohort studies associating (apparently non-syndromic) joint hypermobility and gastrointestinal involvement, (ii) case-control/cohort studies associating JHS/EDS-HT and gastrointestinal involvement, (iii) case reports/series on various gastrointestinal complications in (presumed) JHS/EDS-HT, and (iv) studies reporting gastrointestinal features in heterogeneous EDS patients' cohorts. Gastrointestinal manifestations of JHS/EDS-HT were organized and discussed in two categories, including structural anomalies (i.e., abdominal/diaphragmatic hernias, internal organ/pelvic prolapses, intestinal intussusceptions) and functional features (i.e., dysphagia, gastro-esophageal reflux, dyspepsia, recurrent abdominal pain, constipation/diarrhea), with emphasis on practice and future implications. In the second part of this paper, a summary of possible nutritional interventions in JHS/EDS-HT was presented. Supplementation strategies were borrowed from data available for general population with minor modifications in the light of recent discoveries in the pathogenesis of selected JHS/EDS-HT features. PMID

  5. Joint Engagement and the Emergence of Language in Children with Autism and Down Syndrome

    ERIC Educational Resources Information Center

    Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Romski, MaryAnn

    2009-01-01

    Systematic longitudinal observations were made as typically developing toddlers and young children with autism and with Down syndrome interacted with their caregivers in order to document how joint engagement developed over a year-long period and how variations in joint engagement experiences predicted language outcome. Children with autism…

  6. Kinematic and Electromyographic Characteristics of Single-Joint Movements of Individuals with Down Syndrome.

    ERIC Educational Resources Information Center

    Latash, M. L.; Corcos, D. M.

    1991-01-01

    This study of single-joint elbow flexion movements by 10 subjects with Down's syndrome (ages 14-19) and 6 control subjects concluded that there are no major qualitative deficits in the motor control mechanisms of individuals with Down's syndrome, but there might be problems with proper modulation of motor commands. (Author/JDD)

  7. Benign joint hypermobility syndrome in soldiers; what is the effect of military training courses on associated joint instabilities?

    PubMed Central

    Azma, Kamran; Mottaghi, Peyman; Hosseini, Alireza; Abadi, Hossein Hassan; Nouraei, Mohammad Hadi

    2014-01-01

    Background: Hypermobile joints are joints with beyond normal range of motion and may be associated with joint derangements. This study aimed to evaluate the prevalence of benign joint hypermobility syndrome (BJHS) among soldiers and effect of training courses on related joint instabilities. Materials and Methods: In a prospective cohort study on 721 soldiers of Iran Army in Isfahan in 2013 the prevalence of joint hypermobility was obtained by using Beighton criteria. Soldiers divided in two groups of healthy and suffered based on their scores. The prevalence of ankle sprain, shoulder and temporomandibular joint (TMJ) dislocations identified before beginning service by history-taking and reviewing paraclinical documents. After 3 months of military training, a recent occurrence of mentioned diseases was revaluated in two groups. The collected data were analyzed using SPSS-20 software using Independent-T and Chi-square tests. Results: The frequency of BJHS before military training was 29.4%. After passing military training period, the incidence of ankle sprain was significantly higher in suffered group achieving the minimum Beighton score (BS) of 4 (4.3%, P = 0.03), 5 (5.5%, P = 0.005) and also 6 out of 9 (6.5%, P = 0.01). The incidence of TMJ dislocation was not significantly different based on a minimum score of 4, while it was higher in suffered group when considering the score of 5 (2.1%) and 6 (2.6%) for discrimination of two groups (P = 0.03). There was no significant difference between two groups in case of shoulder dislocation anyway. Conclusion: Military training can increase the incidence of ankle sprains and TMJ dislocations in hypermobility persons with higher BS in comparison with healthy people. Therefore, screening of joint hypermobility may be useful in identifying individuals at increased risk for joint instabilities. PMID:25364364

  8. Interventional radiology in bone and joint

    SciTech Connect

    Bard, M.; Laredo, J.D.

    1988-01-01

    Recent radiologic procedures in bone and joints, some of which eliminate the need for surgery are exposed, including: trephine biopsies of the thoracic and lumbar spine, sacro-iliac joints, peripheral bones synovial membrane and soft tissues, using either fluoroscopic echographic or CT guidance - chemonucleolysis - vascular embolization of skeletal tumors and management of vertebral hemangiomas - selective steroid injection in a broad spectrum of diseases including vertebral facet syndrome, cervicobrachial nerve root pain, rotator cuff calcium deposit, bone cysts.

  9. The effect of different design concepts in lumbar total disc arthroplasty on the range of motion, facet joint forces and instantaneous center of rotation of a L4-5 segment

    PubMed Central

    Midderhoff, Stefan; Adkins, Kyle; Wilke, Hans-Joachim

    2009-01-01

    Although both unconstrained and constrained core lumbar artificial disc designs are in clinical use, the effect of their design on the range of motion, center of rotations, and facet joint forces is not well understood. It is assumed that the constrained configuration causes a fixed center of rotation with high facet forces, while the unconstrained configuration leads to a moving center of rotation with lower loaded facets. The authors disagree with both assumptions and hypothesized that the two different designs do not lead to substantial differences in the results. For the different implant designs, a three-dimensional finite element model was created and subsequently inserted into a validated model of a L4-5 lumbar spinal segment. The unconstrained design was represented by two implants, the Charité® disc and a newly developed disc prosthesis: Slide-Disc®. The constrained design was obtained by a modification of the Slide-Disc® whereby the inner core was rigidly connected to the lower metallic endplate. The models were exposed to an axial compression preload of 1,000 N. Pure unconstrained moments of 7.5 Nm were subsequently applied to the three anatomical main planes. Except for extension, the models predicted only small and moderate inter-implant differences. The calculated values were close to those of the intact segment. For extension, a large difference of about 45% was calculated between both Slide-Disc designs and the Charité® disc. The models predicted higher facet forces for the implants with an unconstrained core compared to an implant with a constrained core. All implants caused a moving center of rotation. Except for axial rotation, the unconstrained and constrained configurations mimicked the intact situation. In axial rotation, only the Slide-Disc® with mobile core reproduced the intact behavior. Results partially support our hypothesis and imply that different implant designs do not lead to strong differences in the range of motion and the

  10. Assessing Joint Attention Responding and Initiation in Children with Angelman Syndrome

    ERIC Educational Resources Information Center

    Summers, Jane; Impey, Julie

    2011-01-01

    Background: Angelman syndrome (AS) is a rare neurogenetic disorder that overlaps with autism and is associated with severe cognitive, speech and motor impairments. Communication and social deficits are found among children with AS, both of which may be linked to impairments in joint attention. Methods: The participants in this study were four…

  11. Thumb Carpometacarpal Joint Stabilization in Ehlers-Danlos Syndrome--Case Report.

    PubMed

    Breahna, Anca Nicoleta; Meads, Bryce Maurice

    2015-10-01

    We report the case of an 18-years-old patient with thumb carpometacarpal ligament laxity due to Ehlers-Danlos syndrome who was treated with trapezial opening wedge osteotomy combined with volar ligaments reconstruction. Two years postoperatively she is pain free and the thumb carpometacarpal joint is stable.

  12. Joint Attention Behaviours and Vocabulary Development in Children with Down Syndrome

    ERIC Educational Resources Information Center

    Zampini, L.; Salvi, A.; D'Odorico, L.

    2015-01-01

    Background: Because of their difficulties in language development, various studies have focussed on the precursors of linguistic skills in children with Down syndrome. However, data on the predictive role of joint attention on language development in this population are inconsistent. The present study aimed to analyse attention behaviours in a…

  13. Early Interests and Joint Engagement in Typical Development, Autism, and Down Syndrome

    ERIC Educational Resources Information Center

    Adamson, Lauren B.; Deckner, Deborah F.; Bakeman, Roger

    2010-01-01

    This study examines how spontaneous interests in people and in objects relate to joint engagement in typically developing toddlers and young children with autism or Down syndrome. Ratings of interests were made repeatedly during intermissions in a laboratory-based protocol focused on caregiver-child interactions. Interests were moderated by…

  14. Thumb Carpometacarpal Joint Stabilization in Ehlers-Danlos Syndrome--Case Report.

    PubMed

    Breahna, Anca Nicoleta; Meads, Bryce Maurice

    2015-10-01

    We report the case of an 18-years-old patient with thumb carpometacarpal ligament laxity due to Ehlers-Danlos syndrome who was treated with trapezial opening wedge osteotomy combined with volar ligaments reconstruction. Two years postoperatively she is pain free and the thumb carpometacarpal joint is stable. PMID:26388011

  15. Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised.

    PubMed

    Sinibaldi, Lorenzo; Ursini, Gianluca; Castori, Marco

    2015-03-01

    Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers-Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome - JHS/EDS-HT), and significantly contributes to the quality of life of affected individuals. Most published articles dealt with the link between gJHM (or JHS/EDS-HT) and anxiety-related conditions, and a novel generation of studies is emerging aimed at investigating the psychopathologic background of such an association. In this paper, literature review was carried out with a semi-systematic approach spanning the entire spectrum of psychopathological findings in gJHM and JHS/EDS-HT. Interestingly, in addition to the confirmation of a tight link between anxiety and gJHM, preliminary connections with depression, attention deficit (and hyperactivity) disorder, autism spectrum disorders, and obsessive-compulsive personality disorder were also found. Few papers investigated the relationship with schizophrenia with contrasting results. The mind-body connections hypothesized on the basis of available data were discussed with focus on somatotype, presumed psychopathology, and involvement of the extracellular matrix in the central nervous system. The hypothesis of positive Beighton score and alteration of interoceptive/proprioceptive/body awareness as possible endophenotypes in families with symptomatic gJHM or JHS/EDS-HT is also suggested. Concluding remarks addressed the implications of the psychopathological features of gJHM and JHS/EDS-HT in clinical practice.

  16. Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised.

    PubMed

    Sinibaldi, Lorenzo; Ursini, Gianluca; Castori, Marco

    2015-03-01

    Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers-Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome - JHS/EDS-HT), and significantly contributes to the quality of life of affected individuals. Most published articles dealt with the link between gJHM (or JHS/EDS-HT) and anxiety-related conditions, and a novel generation of studies is emerging aimed at investigating the psychopathologic background of such an association. In this paper, literature review was carried out with a semi-systematic approach spanning the entire spectrum of psychopathological findings in gJHM and JHS/EDS-HT. Interestingly, in addition to the confirmation of a tight link between anxiety and gJHM, preliminary connections with depression, attention deficit (and hyperactivity) disorder, autism spectrum disorders, and obsessive-compulsive personality disorder were also found. Few papers investigated the relationship with schizophrenia with contrasting results. The mind-body connections hypothesized on the basis of available data were discussed with focus on somatotype, presumed psychopathology, and involvement of the extracellular matrix in the central nervous system. The hypothesis of positive Beighton score and alteration of interoceptive/proprioceptive/body awareness as possible endophenotypes in families with symptomatic gJHM or JHS/EDS-HT is also suggested. Concluding remarks addressed the implications of the psychopathological features of gJHM and JHS/EDS-HT in clinical practice. PMID:25821094

  17. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP.

    PubMed

    Nizetic, Dean; Chen, Christopher L; Hong, Wanjin; Koo, Edward H

    2015-01-01

    People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree of severity, and also have a high risk of early Alzheimer's disease (AD). ID prior to the onset of dementia, and its relationship to the onset of dementia in DS is a complex phenomenon influenced by many factors, and scarcely understood. Unraveling the causative factors and modulators of these processes remains a challenge, with potential to be informative for both ID and AD, for the development of early biomarkers and/or therapeutic approaches. We review the potential relative and inter-connected roles of the chromosome 21 gene for amyloid precursor protein (APP), in both pathological conditions. Rare non-DS people with duplication of APP (dupAPP) get familial early onset AD (FEOAD) with virtually 100% penetrance and prominent cerebrovascular pathology, but don't suffer from ID before dementia onset. All of these features appear to be radically different in DS. On the other hand, rare individuals with partial trisomy 21 (T21) (with APP, but not DS-critical region in trisomy) have been described having ID. Likewise, partial T21 DS (without APP trisomy) show a range of ID, but no AD pathology. We review the multi-faceted roles of APP that might affect cognitive functioning. Given the fact that both Aβ secretion and synaptic maturation/plasticity are dependent on neuronal activity, we explore how this conflicting inter-dependency might affect cognitive pathogenesis in a dynamic way in DS, throughout the lifespan of an individual. PMID:26648852

  18. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

    PubMed Central

    Nizetic, Dean; Chen, Christopher L.; Hong, Wanjin; Koo, Edward H.

    2015-01-01

    People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree of severity, and also have a high risk of early Alzheimer's disease (AD). ID prior to the onset of dementia, and its relationship to the onset of dementia in DS is a complex phenomenon influenced by many factors, and scarcely understood. Unraveling the causative factors and modulators of these processes remains a challenge, with potential to be informative for both ID and AD, for the development of early biomarkers and/or therapeutic approaches. We review the potential relative and inter-connected roles of the chromosome 21 gene for amyloid precursor protein (APP), in both pathological conditions. Rare non-DS people with duplication of APP (dupAPP) get familial early onset AD (FEOAD) with virtually 100% penetrance and prominent cerebrovascular pathology, but don't suffer from ID before dementia onset. All of these features appear to be radically different in DS. On the other hand, rare individuals with partial trisomy 21 (T21) (with APP, but not DS-critical region in trisomy) have been described having ID. Likewise, partial T21 DS (without APP trisomy) show a range of ID, but no AD pathology. We review the multi-faceted roles of APP that might affect cognitive functioning. Given the fact that both Aβ secretion and synaptic maturation/plasticity are dependent on neuronal activity, we explore how this conflicting inter-dependency might affect cognitive pathogenesis in a dynamic way in DS, throughout the lifespan of an individual. PMID:26648852

  19. Strategies for achieving joint attention when signing to children with Down's syndrome.

    PubMed

    Clibbens, John; Powell, Gaye G; Atkinson, Ellen

    2002-01-01

    Research indicates that joint attention is an important factor in determining the rate and nature of early vocabulary development in typically developing children. Studies conducted with deaf children acquiring sign language indicate that caregivers adopt special strategies for achieving joint attention with this group: these strategies make allowance for the visual medium in which the language is transmitted. Joint attention is also important for the development of communication in children with Down's syndrome, who also often have restricted attentional capacity. Moreover, there is good evidence that the use of signed input in addition to speech can have significant benefits for these children. This paper reports on a study designed to explore the utility of strategies observed in deaf parents for the achievement of joint attention when signing with children with Down's syndrome. Data are presented from recordings of four children with Down's syndrome and their mothers. The results showed that the mothers were successful in enabling the child to perceive both signed input and contextual referents much of the time, but that the range of strategies used was very limited compared to deaf parents of deaf children. Adopting a wider range of strategies would allow a considerable increase in signed input. Implications for intervention programmes are discussed. PMID:12201980

  20. [Temporo-mandibular joint pain dysfunction syndrome in children].

    PubMed

    Gagnon, P P

    1978-12-01

    Otalgia is a common symptom in children. Otological examination usually reveals a local pathology as the causative agent. However, it does occur that otoscopy reveals normal ear drums and canals. The otologist must then review the causes of referred otalgia. We know that the ear is a nervous crossroad: vagus, trigeminal and third cervical nerve. The most common causes of referred otalgia are the teeth, the sinus, the mouth, the pharynx, and the larynx. If none of these factors is involved, one must then think about the painful temporomandibular dysfunction syndrome.

  1. Functional assessments of the knee joint biomechanics by using pendulum test in adults with Down syndrome.

    PubMed

    Casabona, Antonino; Valle, Maria Stella; Pisasale, Mariangela; Pantò, Maria Rosita; Cioni, Matteo

    2012-12-01

    In this study, we assessed kinematics and viscoelastic features of knee joint in adults with Down syndrome (DS) by means of the Wartenberg pendulum test. This test allows the measuring of the kinematics of the knee joint during passive pendular motion of leg under the influence of gravity. In addition, by a combination of kinematic and anthropometric data, pendulum test provides estimates of joint viscoelastic properties by computing damping and stiffness coefficients. To monitor the occurrences of muscle activation, the surface electromyogram (EMG) of muscle rectus femoris was recorded. The experimental protocol was performed in a group of 10 adults with DS compared with 10 control adults without DS. Joint motion amplitude, velocity, and acceleration of the leg during the first knee flexion significantly decreased in persons with DS with respect to those without DS. This behavior was associated with the activation of rectus femoris in subjects with DS that resulted in increasing of joint resistance shortly after the onset of the first leg flexion. The EMG bursts mostly occurred between 50 and 150 ms from the leg flexion onset. During the remaining cycles of pendular motion, persons with DS exhibited passive leg oscillations with low tonic EMG activity and reduced damping coefficient compared with control subjects. These results suggest that adults with DS might perform preprogrammed contractions to increase joint resistance and compensate for inherent joint instability occurring for quick and unpredictable perturbations. The reduction of damping coefficients observed during passive oscillations could be a predictor of muscle hypotonia.

  2. A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Puledda, Francesca; Viganò, Alessandro; Celletti, Claudia; Petolicchio, Barbara; Toscano, Massimiliano; Vicenzini, Edoardo; Castori, Marco; Laudani, Guido; Valente, Donatella; Camerota, Filippo; Di Piero, Vittorio

    2015-08-01

    Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue disorders strongly associated with musculoskeletal pain, fatigue and headache. Migraine with or without aura is considered the most common form of headache in JHS/EDS-HT. In this population of chronically ill patients, we investigated whether migraine characteristics were different from those of a control population of migraine patients. The study was carried out on 33 selected JHS/EDS-HT patients, diagnosed according to current criteria. Sixty-six migraine subjects matching age and gender were consecutively selected as controls (MO group) among patients attending our Headache Clinic. JHS/EDS-HT and MO were screened for a series of headache characteristics, such as frequency, intensity, age of onset, level of disability, use of rescue and prophylactic medications. Differences between the two groups were tested by using independent group comparisons. Results showed that in JHS/EDS-HT: (1) migraine has an earlier onset (12.6 vs 17 years of age; p = 0.005); (2) the rate of migraine days/month is higher (15 vs 9.3 days/month; p = 0.01); (3) accompanying symptoms are usually more frequent; (4) HIT-6 and MIDAS scores are higher (p = 0.04 and p = 0.03); (5) efficacy of rescue medication is almost identical, although, total drug consumption is significantly lower (p < 0.04). Joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type patients have a more severe headache syndrome with respect to the MO group, therefore demonstrating that migraine has a very high impact on quality of life in this disease.

  3. A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Puledda, Francesca; Viganò, Alessandro; Celletti, Claudia; Petolicchio, Barbara; Toscano, Massimiliano; Vicenzini, Edoardo; Castori, Marco; Laudani, Guido; Valente, Donatella; Camerota, Filippo; Di Piero, Vittorio

    2015-08-01

    Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue disorders strongly associated with musculoskeletal pain, fatigue and headache. Migraine with or without aura is considered the most common form of headache in JHS/EDS-HT. In this population of chronically ill patients, we investigated whether migraine characteristics were different from those of a control population of migraine patients. The study was carried out on 33 selected JHS/EDS-HT patients, diagnosed according to current criteria. Sixty-six migraine subjects matching age and gender were consecutively selected as controls (MO group) among patients attending our Headache Clinic. JHS/EDS-HT and MO were screened for a series of headache characteristics, such as frequency, intensity, age of onset, level of disability, use of rescue and prophylactic medications. Differences between the two groups were tested by using independent group comparisons. Results showed that in JHS/EDS-HT: (1) migraine has an earlier onset (12.6 vs 17 years of age; p = 0.005); (2) the rate of migraine days/month is higher (15 vs 9.3 days/month; p = 0.01); (3) accompanying symptoms are usually more frequent; (4) HIT-6 and MIDAS scores are higher (p = 0.04 and p = 0.03); (5) efficacy of rescue medication is almost identical, although, total drug consumption is significantly lower (p < 0.04). Joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type patients have a more severe headache syndrome with respect to the MO group, therefore demonstrating that migraine has a very high impact on quality of life in this disease. PMID:25791889

  4. Syndromic Surveillance System for Korea-US Joint Biosurveillance Portal: Design and Lessons Learned.

    PubMed

    Rhee, Chulwoo; Burkom, Howard; Yoon, Chang-Gyo; Stewart, Miles; Elbert, Yevgeniy; Katz, Aaron; Tak, Sangwoo

    2016-01-01

    Driven by the growing importance of situational awareness of bioterrorism threats, the Republic of Korea (ROK) and the United States have constructed a joint military capability, called the Biosurveillance Portal (BSP), to enhance biosecurity. As one component of the BSP, we developed the Military Active Real-time Syndromic Surveillance (MARSS) system to detect and track natural and deliberate disease outbreaks. This article describes the ROK military health data infrastructure and explains how syndromic data are derived and made available to epidemiologists. Queries corresponding to 8 syndromes, based on published clinical effects of weaponized pathogens, were used to classify military hospital patient records to form aggregated daily syndromic counts. A set of ICD-10 codes for each syndrome was defined through literature review and expert panel discussion. A study set of time series of national daily counts for each syndrome was extracted from the Defense Medical Statistical Information System between January 1, 2011, and May 31, 2014. A stratified, adjusted cumulative summation algorithm was implemented for each syndrome group to signal alerts prompting investigation. The algorithm was developed by calculating sensitivity to sets of 1,000 artificial outbreak signals randomly injected in the dataset, with each signal injected in a separate trial. Queries and visualizations were adapted from the Suite for Automated Global bioSurveillance. Findings indicated that early warning of outbreaks affecting fewer than 50 patients will require analysis at subnational levels, especially for common syndrome groups. Developing MARSS to improve sensitivity will require modification of underlying syndromic diagnosis codes, engineering to coordinate alerts among subdivisions, and enhanced algorithms. The bioterrorist threat in the Korean peninsula mandates these efforts. PMID:27314655

  5. Antley-Bixler syndrome: a disorder characterized by congenital synostosis of the elbow joint and the cranial suture.

    PubMed

    Kitoh, H; Nogami, H; Oki, T; Arao, K; Nagasaka, M; Tanaka, Y

    1996-01-01

    The Antley-Bixler syndrome is a rare disorder characterized by craniosynostosis, midface hypoplasia, radiohumeral synostosis, joint contractures, arachnodactyly, and femoral bowing and fractures. We report four cases with this disorder, all of which had craniosynostosis, midface hypoplasia with characteristic facial appearance, and contractures of bilateral elbow joints. However, femoral bowing, fractures, and arachnodactyly were not seen in our patients. In addition, proximal phalanges of the thumb and the great toe showed deformity of the delta phalanx in two cases. Characteristic features in these cases were the synostotic deformity of the elbow joint; three had radioulnahumeral synostosis, and one had radioulnar synostosis. Therefore, our cases indicated that various synostotic patterns of the elbow joints may exist in this syndrome. It is reasonable to propose that characteristic craniofacial appearance associated with the synostosis of the elbow joints of various forms should be considered minimal diagnostic criteria of the Antley-Bixler syndrome. PMID:8742293

  6. Early interests and joint engagement in typical development, autism, and Down syndrome.

    PubMed

    Adamson, Lauren B; Deckner, Deborah F; Bakeman, Roger

    2010-06-01

    This study examines how spontaneous interests in people and in objects relate to joint engagement in typically developing toddlers and young children with autism or Down syndrome. Ratings of interests were made repeatedly during intermissions in a laboratory-based protocol focused on caregiver-child interactions. Interests were moderated by diagnosis and relatively stable across intermissions. In autism, interest in people tended to be low and to decline rapidly, and the balance of interests favored familiar objects over people. Lower interest in people and in unfamiliar objects was associated with less coordinated joint engagement and with less steep developmental trajectories for symbol-infused joint engagement. These findings suggest that variations in interests may contribute to differences in the child's engagement during social interactions that facilitate the acquisition of language.

  7. Effects of Neoprene Wrist/Hand Splints on Handwriting for Students with Joint Hypermobility Syndrome: A Single System Design Study

    ERIC Educational Resources Information Center

    Frohlich, Lauren; Wesley, Alison; Wallen, Margaret; Bundy, Anita

    2012-01-01

    Purpose: Pain associated with hypermobility of wrist and hand joints can contribute to decreased handwriting output. This study examined the effectiveness of a neoprene wrist/hand splint in reducing pain and increasing handwriting speed and endurance for students with joint hypermobility syndrome. Methods: Multiple baseline, single system design…

  8. Controlled medial branch anesthetic block in the diagnosis of chronic lumbar facet joint pain: the value of a three-month follow-up

    PubMed Central

    da Rocha, Ivan Dias; Cristante, Alexandre Fogaça; Marcon, Raphael Martus; Oliveira, Reginaldo Perilo; Letaif, Olavo Biraghi; de Barros Filho, Tarcisio Eloy Pessoa

    2014-01-01

    OBJECTIVES: To verify the incidence of facetary and low back pain after a controlled medial branch anesthetic block in a three-month follow-up and to verify the correlation between the positive results and the demographic variables. METHODS: Patients with chronic lumbar pain underwent a sham blockade (with a saline injection) and then a controlled medial branch block. Their symptoms were evaluated before and after the sham injection and after the real controlled medial branch block; the symptoms were reevaluated after one day and one week, as well as after one, two and three months using the visual analog scale. We searched for an association between the positive results and the demographic characteristics of the patients. RESULTS: A total of 104 controlled medial branch blocks were performed and 54 patients (52%) demonstrated >50% improvements in pain after the blockade. After three months, lumbar pain returned in only 18 individuals, with visual analogue scale scores >4. Therefore, these patients were diagnosed with chronic facet low back pain. The three-months of follow-up after the controlled medial branch block excluded 36 patients (67%) with false positive results. The results of the controlled medial branch block were not correlated to sex, age, pain duration or work disability but were correlated with patient age (p<0.05). CONCLUSION: Patient diagnosis with a controlled medial branch block proved to be effective but was not associated with any demographic variables. A three-month follow-up is required to avoid a high number of false positives. PMID:25141111

  9. Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type.

    PubMed

    Chiarelli, Nicola; Carini, Giulia; Zoppi, Nicoletta; Dordoni, Chiara; Ritelli, Marco; Venturini, Marina; Castori, Marco; Colombi, Marina

    2016-01-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT), is likely the most common systemic heritable connective tissue disorder, and is mostly recognized by generalized joint hypermobility, joint instability complications, minor skin changes and a wide range of satellite features. JHS/EDS-HT is considered an autosomal dominant trait but is still without a defined molecular basis. The absence of (a) causative gene(s) for JHS/EDS-HT is likely attributable to marked genetic heterogeneity and/or interaction of multiple loci. In order to help in deciphering such a complex molecular background, we carried out a comprehensive immunofluorescence analysis and gene expression profiling in cultured skin fibroblasts from five women affected with JHS/EDS-HT. Protein study revealed disarray of several matrix structural components such as fibrillins, tenascins, elastin, collagens, fibronectin, and their integrin receptors. Transcriptome analysis indicated perturbation of different signaling cascades that are required for homeostatic regulation either during development or in adult tissues as well as altered expression of several genes involved in maintenance of extracellular matrix architecture and homeostasis (e.g., SPON2, TGM2, MMP16, GPC4, SULF1), cell-cell adhesion (e.g., CDH2, CHD10, PCDH9, CLDN11, FLG, DSP), immune/inflammatory/pain responses (e.g., CFD, AQP9, COLEC12, KCNQ5, PRLR), and essential for redox balance (e.g., ADH1C, AKR1C2, AKR1C3, MAOB, GSTM5). Our findings provide a picture of the gene expression profile and dysregulated pathways in JHS/EDS-HT skin fibroblasts that correlate well with the systemic phenotype of the patients. PMID:27518164

  10. Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type

    PubMed Central

    Chiarelli, Nicola; Carini, Giulia; Zoppi, Nicoletta; Dordoni, Chiara; Ritelli, Marco; Venturini, Marina; Castori, Marco; Colombi, Marina

    2016-01-01

    Joint hypermobility syndrome/Ehlers–Danlos syndrome hypermobility type (JHS/EDS-HT), is likely the most common systemic heritable connective tissue disorder, and is mostly recognized by generalized joint hypermobility, joint instability complications, minor skin changes and a wide range of satellite features. JHS/EDS-HT is considered an autosomal dominant trait but is still without a defined molecular basis. The absence of (a) causative gene(s) for JHS/EDS-HT is likely attributable to marked genetic heterogeneity and/or interaction of multiple loci. In order to help in deciphering such a complex molecular background, we carried out a comprehensive immunofluorescence analysis and gene expression profiling in cultured skin fibroblasts from five women affected with JHS/EDS-HT. Protein study revealed disarray of several matrix structural components such as fibrillins, tenascins, elastin, collagens, fibronectin, and their integrin receptors. Transcriptome analysis indicated perturbation of different signaling cascades that are required for homeostatic regulation either during development or in adult tissues as well as altered expression of several genes involved in maintenance of extracellular matrix architecture and homeostasis (e.g., SPON2, TGM2, MMP16, GPC4, SULF1), cell-cell adhesion (e.g., CDH2, CHD10, PCDH9, CLDN11, FLG, DSP), immune/inflammatory/pain responses (e.g., CFD, AQP9, COLEC12, KCNQ5, PRLR), and essential for redox balance (e.g., ADH1C, AKR1C2, AKR1C3, MAOB, GSTM5). Our findings provide a picture of the gene expression profile and dysregulated pathways in JHS/EDS-HT skin fibroblasts that correlate well with the systemic phenotype of the patients. PMID:27518164

  11. Knowledge, assessment, and management of adults with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type among Flemish physiotherapists.

    PubMed

    Rombaut, Lies; Deane, Janet; Simmonds, Jane; De Wandele, Inge; De Paepe, Anne; Malfait, Fransiska; Calders, Patrick

    2015-03-01

    Physiotherapy plays a fundamental role in managing adults with the joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT). However, it is a challenge for both the patient and the physiotherapist as the condition is poorly understood and treatment for JHS/EDS-HT is currently undefined. Insight into current practice is, therefore, necessary in order to establish baseline knowledge in this area and in the long term to improve the standard of patient care. Therefore, the purpose of this study was to evaluate current physiotherapists' knowledge of JHS/EDS-HT and to gain insight into current physiotherapy practice with emphasis on assessment, management, and treatment efficacy. Three hundred twenty-five Flemish physiotherapists participated in the study by filling out electronically a modified version of the "Hypermobility and Hypermobility Syndrome Questionnaire" (HHQ), which covered theoretical constructs such as general knowledge, assessment, management, and learning in relation to generalized joint hypermobility and JHS/EDS-HT. The results show that physiotherapists report a low level of confidence with regard to assessment and management of JHS/EDS-HT. Knowledge of hypermobility and JHS/EDS-HT is weak, especially regarding the features associated with JHS/EDS-HT. Many treatment approaches are used by physiotherapists with the majority showing preference for education, reassurance, muscle strengthening, proprioceptive and core stability training. Almost all approaches were perceived as being clinically effective by the physiotherapists, highlighting a lack of consensus. In conclusion, this study in Flemish physiotherapists confirms that JHS/EDS-HT is under-recognized, not well known and deemed difficult to treat. Further education is required and sought by the physiotherapists surveyed, and future research is needed.

  12. Knowledge, assessment, and management of adults with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type among Flemish physiotherapists.

    PubMed

    Rombaut, Lies; Deane, Janet; Simmonds, Jane; De Wandele, Inge; De Paepe, Anne; Malfait, Fransiska; Calders, Patrick

    2015-03-01

    Physiotherapy plays a fundamental role in managing adults with the joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT). However, it is a challenge for both the patient and the physiotherapist as the condition is poorly understood and treatment for JHS/EDS-HT is currently undefined. Insight into current practice is, therefore, necessary in order to establish baseline knowledge in this area and in the long term to improve the standard of patient care. Therefore, the purpose of this study was to evaluate current physiotherapists' knowledge of JHS/EDS-HT and to gain insight into current physiotherapy practice with emphasis on assessment, management, and treatment efficacy. Three hundred twenty-five Flemish physiotherapists participated in the study by filling out electronically a modified version of the "Hypermobility and Hypermobility Syndrome Questionnaire" (HHQ), which covered theoretical constructs such as general knowledge, assessment, management, and learning in relation to generalized joint hypermobility and JHS/EDS-HT. The results show that physiotherapists report a low level of confidence with regard to assessment and management of JHS/EDS-HT. Knowledge of hypermobility and JHS/EDS-HT is weak, especially regarding the features associated with JHS/EDS-HT. Many treatment approaches are used by physiotherapists with the majority showing preference for education, reassurance, muscle strengthening, proprioceptive and core stability training. Almost all approaches were perceived as being clinically effective by the physiotherapists, highlighting a lack of consensus. In conclusion, this study in Flemish physiotherapists confirms that JHS/EDS-HT is under-recognized, not well known and deemed difficult to treat. Further education is required and sought by the physiotherapists surveyed, and future research is needed. PMID:25821093

  13. Low tendon stiffness and abnormal ultrastructure distinguish classic Ehlers-Danlos syndrome from benign joint hypermobility syndrome in patients.

    PubMed

    Nielsen, Rie Harboe; Couppé, Christian; Jensen, Jacob Kildevang; Olsen, Morten Raun; Heinemeier, Katja Maria; Malfait, Fransiska; Symoens, Sofie; De Paepe, Anne; Schjerling, Peter; Magnusson, Stig Peter; Remvig, Lars; Kjaer, Michael

    2014-11-01

    There is a clinical overlap between classic Ehlers-Danlos syndrome (cEDS) and benign joint hypermobility syndrome (BJHS), with hypermobility as the main symptom. The purpose of this study was to investigate the role of type V collagen mutations and tendon pathology in these 2 syndromes. In patients (cEDS, n=7; BJHS, n=8) and controls (Ctrl, n=8), we measured patellar tendon ultrastructure (transmission electron microscopy), dimensions (magnetic resonance imaging), and biomechanical properties (force and ultrasonographic measurements during a ramped isometric knee extension). Mutation analyses (COL5A1 and COL5A2) were performed in the patients. COL5A1 mutations were found in 3 of 4 of the patients with cEDS. Patellar tendon dimensions were similar between the groups, but large, irregular collagen fibrils were in 4 of 5 patients with cEDS. In the cEDS group, tendon stiffness and Young's modulus were reduced to ∼50% of that in BJHS and Ctrl groups (P<0.05). The nonhypermobile, healthy controls were matched with the patients in age, sex, body weight, and physical activity, to compare outcomes. COL5A1 mutations led to structural tendon pathology and low tendon stiffness in cEDS, explaining the patients' hypermobility, whereas no tendon pathology was found that explained the hypermobility in BJHS.

  14. Rating parent-child interactions: joint engagement, communication dynamics, and shared topics in autism, Down syndrome, and typical development.

    PubMed

    Adamson, Lauren B; Bakeman, Roger; Deckner, Deborah F; Nelson, P Brooke

    2012-12-01

    A battery of 17 rating items were applied to video records of typically-developing toddlers and young children with autism and Down syndrome interacting with their parents during the Communication Play Protocol. This battery provided a reliable and broad view of the joint engagement triad of child, partner, and shared topic. Ratings of the child's joint engagement correlated very strongly with state coding of joint engagement and replicated the finding that coordinated joint engagement was less likely in children with autism. Ratings of other child actions, of parent contributions, and of shared topics and communicative dynamics also documented pervasive variations related to diagnosis, language facility, and communicative context.

  15. Lower extremity thrust and non-thrust joint mobilization for patellofemoral pain syndrome: a case report

    PubMed Central

    Simpson, Brad G; Simon, Corey B

    2014-01-01

    A 40-year old female presented to physical therapy with a one-year history of insidious right anteromedial and anterolateral knee pain. Additionally, the patient had a history of multiple lateral ankle sprains bilaterally, the last sprain occurring on the right ankle 1 year prior to the onset of knee pain. The patient was evaluated and given a physical therapy diagnosis of patellofemoral pain syndrome (PFPS), with associated talocrural and tibiofemoral joint hypomobility limiting ankle dorsiflexion and knee extension, respectively. Treatment included a high-velocity low amplitude thrust manipulation to the talocrural joint, which helped restore normal ankle dorsiflexion range of motion. The patient also received tibiofemoral joint non-thrust manual therapy to regain normal knee extension mobility prior to implementing further functional progression exercises to her home program (HEP). This case report highlights the importance of a detailed evaluation of knee and ankle joint mobility in patients presenting with anterior knee pain. Further, manual physical therapy to the lower extremity was found to be successful in restoring normal movement patterns and pain-free function in a patient with chronic anterior knee pain. PMID:24976753

  16. Intra-articular fibroma of tendon sheath in a knee joint associated with iliotibial band friction syndrome.

    PubMed

    Ha, Dong-Ho; Choi, Sunseob; Kim, Soo-Jin; Lih, Wang

    2015-01-01

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome. PMID:25598686

  17. Intra-articular fibroma of tendon sheath in a knee joint associated with iliotibial band friction syndrome.

    PubMed

    Ha, Dong-Ho; Choi, Sunseob; Kim, Soo-Jin; Lih, Wang

    2015-01-01

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome.

  18. Intra-Articular Fibroma of Tendon Sheath in a Knee Joint Associated with Iliotibial Band Friction Syndrome

    PubMed Central

    Choi, Sunseob; Kim, Soo-Jin; Lih, Wang

    2015-01-01

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome. PMID:25598686

  19. Personality disorders and regulative styles of patients with temporo-mandibular joint pain dysfunction syndrome.

    PubMed

    Baggi, L; Rubino, I A; Zanna, V; Martignoni, M

    1995-02-01

    A sample of 42 women patients with Temporo-mandibular Joint Pain Dysfunction Syndrome was given the Millon Clinical Multiaxial Inventory-II and the Serial Color-Word Test. Compared with sex- and age-matched nonclinical controls, temporo-mandibular patients had significantly (1) higher scores on the Obsessive-Compulsive scale, (2) lower scores of ITa (a pattern concerned with initial times of response), and (3) higher scores of R (linear increase in reading times during the trials). The latter intergroup difference concerned mainly the first subtest, i.e., temporo-mandibular patients were characterized by higher scores of R from the very beginning of the process of adaptation.

  20. Comparison of the efficacy of saline, local anesthetics, and steroids in epidural and facet joint injections for the management of spinal pain: A systematic review of randomized controlled trials

    PubMed Central

    Manchikanti, Laxmaiah; Nampiaparampil, Devi E.; Manchikanti, Kavita N.; Falco, Frank J.E.; Singh, Vijay; Benyamin, Ramsin M.; Kaye, Alan D.; Sehgal, Nalini; Soin, Amol; Simopoulos, Thomas T.; Bakshi, Sanjay; Gharibo, Christopher G.; Gilligan, Christopher J.; Hirsch, Joshua A.

    2015-01-01

    Background: The efficacy of epidural and facet joint injections has been assessed utilizing multiple solutions including saline, local anesthetic, steroids, and others. The responses to these various solutions have been variable and have not been systematically assessed with long-term follow-ups. Methods: Randomized trials utilizing a true active control design were included. The primary outcome measure was pain relief and the secondary outcome measure was functional improvement. The quality of each individual article was assessed by Cochrane review criteria, as well as the criteria developed by the American Society of Interventional Pain Physicians (ASIPP) for assessing interventional techniques. An evidence analysis was conducted based on the qualitative level of evidence (Level I to IV). Results: A total of 31 trials met the inclusion criteria. There was Level I evidence that local anesthetic with steroids was effective in managing chronic spinal pain based on multiple high-quality randomized controlled trials. The evidence also showed that local anesthetic with steroids and local anesthetic alone were equally effective except in disc herniation, where the superiority of local anesthetic with steroids was demonstrated over local anesthetic alone. Conclusion: This systematic review showed equal efficacy for local anesthetic with steroids and local anesthetic alone in multiple spinal conditions except for disc herniation where the superiority of local anesthetic with steroids was seen over local anesthetic alone. PMID:26005584

  1. NUBEAM Sources in FACETS

    NASA Astrophysics Data System (ADS)

    Pletzer, A.; McCune, D.; Indireshkumar, K.; Morris, A.; Pankin, A.; Cary, J. R.

    2009-05-01

    The SciDAC project for the development of a Framework Application for Core Edge Transport Simulation (FACETS) aims at producing tokamak core-to-wall transport simulations on massively parallel architectures. Here, we report on the progress of integrating the new parallel, PlasmaState based, Monte-Carlo NUBEAM module into the FACETS framework to provide neutral beam and fusion source terms in the plasma core diffusion equations. NUBEAM has recently been improved to facilitate invocation from third party software (e.g. SWIM). This was achieved by consolidating 100s of input variables into separate structures according to machine specificity, shot specificity, or time-slice specificity. Thanks to a combination of auto-generated code and a newly developed methodology for exposing Fortran90 derived types to C, all derived type members of NUBEAM structures have become in-memory accessible to FACETS's C++ infrastructure. NUBEAM, which is the first volumetric-coupling component in FACETS, has been wrapped with methods complying to the FACETS standard interface definition for easy interchangeability of modules at run time. Examples of neutral beam computations instrumented with TAU/Paratools on leadership class machines will be presented, as well as first coupled core-source FACETS simulations.

  2. Unexpected association between joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type and obsessive-compulsive personality disorder.

    PubMed

    Pasquini, Massimo; Celletti, Claudia; Berardelli, Isabella; Roselli, Valentina; Mastroeni, Simona; Castori, Marco; Biondi, Massimo; Camerota, Filippo

    2014-05-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a largely unrecognized, heritable connective tissue disorder, mainly characterized by joint instability complications, widespread musculoskeletal pain, and minor skin features. In a case-control study, 47 consecutive JHS/EDS-HT patients were investigated for the prevalence of psychiatric disorders and compared to 45 healthy controls in a single center. The psychiatric evaluation consisted of structured clinical interview for DSM-IV criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Brief Psychiatric Rating Scale (BPRS). The Global Assessment of Functioning Scale (GAF) was used to assess the overall severity of psychological, social, and occupational functions. JHS/EDS-HT patients had significantly higher mean scores for all questionnaires: HAM-A (6.7 vs. 3.8), HAM-D (6.4 vs. 2.7), GAF (75.0 vs. 86.1), and BPRS (27.5 vs. 25.6). The JHS/EDS-HT group had a 4.3 higher risk of being affected by any psychiatric disorder, and in particular, a 5.8 higher risk of having a personality disorder. In particular, 5 JHS/EDS-HT suffered from obsessive-compulsive personality disorder with an observed prevalence rate of 10.6 % (3.6-23.1). Psychiatric assessment of JHS/EDS-HT patients showed an extremely high prevalence of personality disorders (21 %), and of Axis-I disorders (38 %), mostly depressive. This study did not confirm the previously reported increased rate of panic disorders in JHS/EDS-HT. PMID:24272065

  3. Unexpected association between joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type and obsessive-compulsive personality disorder.

    PubMed

    Pasquini, Massimo; Celletti, Claudia; Berardelli, Isabella; Roselli, Valentina; Mastroeni, Simona; Castori, Marco; Biondi, Massimo; Camerota, Filippo

    2014-05-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a largely unrecognized, heritable connective tissue disorder, mainly characterized by joint instability complications, widespread musculoskeletal pain, and minor skin features. In a case-control study, 47 consecutive JHS/EDS-HT patients were investigated for the prevalence of psychiatric disorders and compared to 45 healthy controls in a single center. The psychiatric evaluation consisted of structured clinical interview for DSM-IV criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Brief Psychiatric Rating Scale (BPRS). The Global Assessment of Functioning Scale (GAF) was used to assess the overall severity of psychological, social, and occupational functions. JHS/EDS-HT patients had significantly higher mean scores for all questionnaires: HAM-A (6.7 vs. 3.8), HAM-D (6.4 vs. 2.7), GAF (75.0 vs. 86.1), and BPRS (27.5 vs. 25.6). The JHS/EDS-HT group had a 4.3 higher risk of being affected by any psychiatric disorder, and in particular, a 5.8 higher risk of having a personality disorder. In particular, 5 JHS/EDS-HT suffered from obsessive-compulsive personality disorder with an observed prevalence rate of 10.6 % (3.6-23.1). Psychiatric assessment of JHS/EDS-HT patients showed an extremely high prevalence of personality disorders (21 %), and of Axis-I disorders (38 %), mostly depressive. This study did not confirm the previously reported increased rate of panic disorders in JHS/EDS-HT.

  4. Heart rate, conduction and ultrasound abnormalities in adults with joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Camerota, Filippo; Castori, Marco; Celletti, Claudia; Colotto, Marco; Amato, Silvia; Colella, Alessandra; Curione, Mario; Danese, Chiara

    2014-07-01

    Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue disorders strongly associating with pain, fatigue and other secondary aspects. Though not considered a diagnostic criterion for most EDS subtypes, cardiovascular involvement is a well-known complication in EDS. A case-control study was carried out on 28 adults with JHS/EDS-HT diagnosed according to current criteria, compared to 29 healthy subjects evaluating resting electrocardiographic (ECG), 24-h ECG and resting heart ultrasound data. Results obtained in the ECG studies showed a moderate excess in duration of the PR interval and P wave, an excess of heart conduction and rate abnormalities and an increased rate of mitral and tricuspid valve insufficiency often complicating with "true" mitral valve prolapse in the ecocardiographic study. These variable ECG subclinical anomalies reported in our sample may represent the resting surrogate of such a subnormal cardiovascular response to postural changes that are known to be present in patients with JHS/EDS-HT. Our findings indicate the usefulness of a full cardiologic evaluation of adults with JHS/EDS-HT for the correct management. PMID:24752348

  5. The role of narrative medicine in the management of joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Knight, Isobel

    2015-03-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a hereditary connective tissue disorder affecting every bodily system. It is largely underdiagnosed by many practitioners, with the result of a considerable delay in diagnosis and, consequently, in the onset of adequate management schedule and treatment. Patients may also experience to be misbelieved, erroneously considered affected by a psychiatric or psychosomatic disorders, and rejected by the medical profession, which can lead to feelings of anger and resentment. Patient journeys are often long and complicated, but if doctors allowed the patient time to tell the full story, and were more prepared to think holistically, there may be a far more positive outcome. Here, the patients' perspective is presented with a narrative medicine approach, illustrating the tri-dimensional experience of a JHS/EDS-HT patient, who is also a Bowen Practitioner and a medical writer/educator. Narrative medicine would be invaluable in working with JHS/EDS-HT so that the patient can tell the story, and offer the practitioner a whole picture of her/his suffering and, often, the key for understanding the cause(s). Once this has been achieved, it might be possible to build upon a more positive and therapeutic dialogue which would result in better treatment and more effective management. It is also important for doctors to communicate with JHS/EDS-HT experts who will ultimately improve the patient journey and treatment outcomes of such a complex connective tissue disorder.

  6. The role of narrative medicine in the management of joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Knight, Isobel

    2015-03-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a hereditary connective tissue disorder affecting every bodily system. It is largely underdiagnosed by many practitioners, with the result of a considerable delay in diagnosis and, consequently, in the onset of adequate management schedule and treatment. Patients may also experience to be misbelieved, erroneously considered affected by a psychiatric or psychosomatic disorders, and rejected by the medical profession, which can lead to feelings of anger and resentment. Patient journeys are often long and complicated, but if doctors allowed the patient time to tell the full story, and were more prepared to think holistically, there may be a far more positive outcome. Here, the patients' perspective is presented with a narrative medicine approach, illustrating the tri-dimensional experience of a JHS/EDS-HT patient, who is also a Bowen Practitioner and a medical writer/educator. Narrative medicine would be invaluable in working with JHS/EDS-HT so that the patient can tell the story, and offer the practitioner a whole picture of her/his suffering and, often, the key for understanding the cause(s). Once this has been achieved, it might be possible to build upon a more positive and therapeutic dialogue which would result in better treatment and more effective management. It is also important for doctors to communicate with JHS/EDS-HT experts who will ultimately improve the patient journey and treatment outcomes of such a complex connective tissue disorder. PMID:25821096

  7. TIBIOFEMORAL JOINT MOBILIZATION IN THE SUCCESSFUL MANAGEMENT OF PATELLOFEMORAL PAIN SYNDROME: A CASE REPORT

    PubMed Central

    Emerson-Kavchak, Alicia J.; Mischke, John J.; Courtney, Carol A.

    2016-01-01

    ABSTRACT Background and Purpose Patellofemoral pain syndrome (PFPS) is a common source of anterior knee pain. Controversy exists over the exact clinical findings which define PFPS, thus, diagnosis and management can be challenging for clinicians. There is paucity in the literature concerning joint mobilization as treatment for PFPS, particularly at the tibiofemoral joint, as standard management is currently focused on therapeutic exercise, orthotics, bracing and taping. Therefore, the purpose of this case report is to describe the effects of tibiofemoral joint mobilization in the successful treatment of an individual with chronic PFPS as it relates to pain, function and central processing of pain. Study Design Case Report Case Description The subject was a 28-year-old female with a two year history of left anterior, inferior patellar knee pain consistent with chronic PFPS. She demonstrated diminished pressure pain threshold (PPT) and allodynia at the anterior knee, suggesting a component of central sensitization to her pain. She met several common diagnostic criteria for PFPS, however, only tibiofemoral anterior-posterior joint mobilization increased her pain. Subsequent treatment sessions (Visits 1-6) consisted of solely joint mobilization supplemented by instruction in a home exercise program (therapeutic exercise and balance training). As outcomes improved, treatment sessions (Visits 7-8) consisted of solely therapeutic exercise and balance training with focus on return to independent pain free functional activity. Outcomes Improvements consistent with the minimally clinically important difference were noted on the Kujala Anterior Knee Pain Scale, Numeric Pain Rating Scale, Global Rating of Change (GROC). Scores on the Fear Avoidance-Belief Questionnaire (6/24 to 2/24 PA, 31/42 to 5/42 W), PPT (119 to 386 kPa) and Step Down Test (11 to 40 steps) also demonstrated improvement. At a two month follow up, the subject reported continued improvement in functional

  8. Temporomandibular joint ankylosis as part of the clinical spectrum of Carey-Fineman-Ziter syndrome?

    PubMed

    Pasetti, Martina; Mazzoleni, Fabio; Novelli, Giorgio; Iascone, Maria; Bozzetti, Alberto; Selicorni, Angelo

    2016-08-01

    The Carey-Finema-Ziter syndrome (CFZS, MIM 254940) is an apparently autosomal recessively inherited disorder consisting of the combination of non-progressive congenital myopathy with Moebius and Pierre Robin sequence, facial anomalies and growth delay. Mental development has been described as normal or delayed. Temporomandibular joint (TMJ) ankylosis is the immobility of the joint caused by ankylotic fusion of the mandible to the cranial base or zygoma. It is a serious and disabling condition that may cause problems in mastication, digestion, speech, appearance, and oral hygiene. Most often is a true ankylosis of the TMJ but other pathological mechanisms are described (i.e., the fusion of the coronoid process to temporal bone or with the zygoma, or a variety of soft tissues disorders like Fibrodysplasia Ossificans Progressiva). Here we report a 2-year-old girl fitting with a clinical diagnosis of CFZS associated with a limited mouth opening in which temporomandibular joint ankylosis was suspected. Because it has been postulated that many clinical features in CFZS may only be secondary effects of brainstem anomalies and muscle weakness during development, the limited opening of the mouth observed in our patient could represent a rare clinical feature of CFZS itself. © 2016 Wiley Periodicals, Inc.

  9. Short stature, severe aortic root dilation, skin hyperextensibility, extreme joint laxity and craniofacial dysmorphic features: a probable new syndrome.

    PubMed

    Verstraeten, Elke; Symoens, Sofie; Renard, Marjolijn; Callewaert, Bert; Vandekerckhove, Kristof; De Backer, Julie; Malfait, Fransiska; Marks, Luc; Coucke, Paul; De Paepe, Anne; Loeys, Bart

    2010-07-01

    We report a 10-year-old male proband, born from consanguineous marriage, presenting with short stature, severe aortic root dilation, skin hyperextensibility, extreme joint laxity and craniofacial dysmorphism. Clinical, biochemical and molecular findings did not match any of the well-described connective tissue syndromes in the differential diagnosis for this specific combination of features. We presume that the phenotype presented in this patient may constitute a newly recognized syndrome of likely autosomal recessive inheritance.

  10. Unusual lesions mimicking impingement syndrome in the shoulder joint - Think medially.

    PubMed

    Singh, Rohit; Malhotra, Akshay; Cribb, Gillian; Cool, Paul; Hay, Stuart

    2016-09-01

    Impingement syndrome is usually caused by irritation of the rotator cuff within the sub acromial space and this includes the coraco-acromial arch (Acromion and Coraco-acromial ligament), the acromio-clavicular joint and occasionally the coracoid. Iatrogenic causes such as sutures, pins, plates or wires left from previous surgery can cause similar symptoms. We present a series of four cases mimicking "classical" impingement symptoms/signs in which the causal pathology was identified outside the sub-acromial space. Magnetic Resonance Imaging (MRI) showed lesions that were present in the supra-spinatus fossa but were causing pressure effects on the sub-acromial space, namely - a ganglion cyst in one case, lipomata in two other cases, and a glomus tumour. A ganglion cyst and glomus tumour mimicking impingement syndrome is a rare reported case to our knowledge. These are unusual causes that should be considered when investigating classical impingement syndrome and particularly those who may have failed to respond to decompression surgery. They highlight the potential value of looking beyond the sub-acromial space for causal lesions and in these cases, at a time when limited ultrasound investigation has become increasingly popular; MRI has clearly played an important and was essential in planning surgery as these lesions would not have been identified on USS. Even though the symptoms were classical. PMID:27594993

  11. First Beam to FACET

    SciTech Connect

    Erickson, R.; Clarke, C.; Colocho, W.; Decker, F.-J.; Hogan, M.; Kalsi, S.; Lipkowitz, N.; Nelson, J.; Phinney, N.; Schuh, P.; Sheppard, J.; Smith, H.; Smith, T.; Stanek, M.; Turner, J.; Warren, J.; Weathersby, S.; Wienands, U.; Wittmer, W.; Woodley, M.; Yocky, G.; /SLAC

    2011-12-13

    The SLAC 3km linear electron accelerator has been reconfigured to provide a beam of electrons to the new Facility for Advanced Accelerator Experimental Tests (FACET) while simultaneously providing an electron beam to the Linac Coherent Light Source (LCLS). On June 23, 2011, the first electron beam was transported through this new facility. Commissioning of FACET is in progress. On June 23, 2011, an electron beam was successfully transported through the new FACET system to a dump in Sector 20 in the linac tunnel. This was achieved while the last third of the linac, operating from the same control room, but with a separate injector system, was providing an electron beam to the Linac Coherent Light Source (LCLS), demonstrating that concurrent operation of the two facilities is practical. With the initial checkout of the new transport line essentially complete, attention is now turning toward compressing the electron bunches longitudinally and focusing them transversely to support a variety of accelerator science experiments.

  12. SLAC All Access: FACET

    SciTech Connect

    Hogan, Mark

    2012-07-05

    SLAC's Facility for Advanced Accelerator Experimental Tests, or FACET, is a test-bed where researchers are developing the technologies required for particle accelerators of the future. Scientists from all over the world come to explore ways of improving the power and efficiency of the particle accelerators used in basic research, medicine, industry and other areas important to society. In this video, Mark Hogan, head of SLAC's Advanced Accelerator Research Department, offers a glimpse into FACET, which uses part of SLAC's historic two-mile-long linear accelerator.

  13. SLAC All Access: FACET

    ScienceCinema

    Hogan, Mark

    2016-07-12

    SLAC's Facility for Advanced Accelerator Experimental Tests, or FACET, is a test-bed where researchers are developing the technologies required for particle accelerators of the future. Scientists from all over the world come to explore ways of improving the power and efficiency of the particle accelerators used in basic research, medicine, industry and other areas important to society. In this video, Mark Hogan, head of SLAC's Advanced Accelerator Research Department, offers a glimpse into FACET, which uses part of SLAC's historic two-mile-long linear accelerator.

  14. Rating Parent-Child Interactions: Joint Engagement, Communication Dynamics, and Shared Topics in Autism, Down Syndrome, and Typical Development

    ERIC Educational Resources Information Center

    Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Nelson, P. Brooke

    2012-01-01

    A battery of 17 rating items were applied to video records of typically-developing toddlers and young children with autism and Down syndrome interacting with their parents during the Communication Play Protocol. This battery provided a reliable and broad view of the joint engagement triad of child, partner, and shared topic. Ratings of the child's…

  15. Spectrum of mucocutaneous manifestations in 277 patients with joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Castori, Marco; Dordoni, Chiara; Morlino, Silvia; Sperduti, Isabella; Ritelli, Marco; Valiante, Michele; Chiarelli, Nicola; Zanca, Arianna; Celletti, Claudia; Venturini, Marina; Camerota, Filippo; Calzavara-Pinton, Piergiacomo; Grammatico, Paola; Colombi, Marina

    2015-03-01

    Cutaneous manifestations are a diagnostic criterion of Ehlers-Danlos syndrome, hypermobility type (EDS-HT) and joint hypermobility syndrome (JHS). These two conditions, originally considered different disorders, are now accepted as clinically indistinguishable and often segregate as a single-familial trait. EDS-HT and JHS are still exclusion diagnoses not supported by any specific laboratory test. Accuracy of clinical diagnosis is, therefore, crucial for appropriate patients' classification and management, but it is actually hampered by the low consistency of many applied criteria including the cutaneous one. We report on mucocutaneous findings in 277 patients with JHS/EDS-HT with both sexes and various ages. Sixteen objective and five anamnestic items were selected and ascertained in two specialized outpatient clinics. Feature rates were compared by sex and age by a series of statistical tools. Data were also used for a multivariate correspondence analysis with the attempt to identify non-causal associations of features depicting recognizable phenotypic clusters. Our findings identified a few differences between sexes and thus indicated an attenuated sexual dimorphism for mucocutaneous features in JHS/EDS-HT. Ten features showed significantly distinct rates at different ages and this evidence corroborated the concept of an evolving phenotype in JHS/EDS-HT also affecting the skin. Multivariate correspondence analysis identified three relatively discrete phenotypic profiles, which may represent the cutaneous counterparts of the three disease phases previously proposed for JHS/EDS-HT. These findings could be used for revising the cutaneous criterion in a future consensus for the clinical diagnosis of JHS/EDS-HT.

  16. Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders.

    PubMed

    Colombi, Marina; Dordoni, Chiara; Chiarelli, Nicola; Ritelli, Marco

    2015-03-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is an evolving and protean disorder mostly recognized by generalized joint hypermobility and without a defined molecular basis. JHS/EDS-HT also presents with other connective tissue features affecting a variety of structures and organs, such as skin, eye, bone, and internal organs. However, most of these signs are present in variable combinations and severity in many other heritable connective tissue disorders. Accordingly, JHS/EDS-HT is an "exclusion" diagnosis which needs the absence of any consistent feature indicative of other partially overlapping connective tissue disorders. While both Villefranche and Brighton criteria include such an exclusion as a mandatory item, a systematic approach for reaching a stringent clinical diagnosis of JHS/EDS-HT is still lacking. The absence of a consensus on the diagnostic approach to JHS/EDS-HT concerning its clinical boundaries with similar conditions contribute to limit our actual understanding of the pathologic and molecular bases of this disorder. In this review, we revise the differential diagnosis of JHS/EDS-HT with those heritable connective tissue disorders which show a significant overlap with the former and mostly include EDS classic, vascular and kyphoscoliotic types, osteogenesis imperfecta, Marfan syndrome, Loeys-Dietz syndrome, arterial tortuosity syndrome, and lateral meningocele syndrome. A diagnostic flow chart is also offered with the attempt to support the less experienced clinician in stringently recognizing JHS/EDS-HT and stimulate the debate in the scientific community for both management and research purposes.

  17. [The dark side of facet joint].

    PubMed

    Barelli, Laurence Perrin; Dettori, Nadia Guzman

    2016-06-22

    Low back pain (LBP) is a major medical and economical problem, because of its high incidence. Indeed, 70-85% of adult people will suffer from this kind of pain once in their life. We will focus in this article on chronic LBP, which represent an annual prevalence of 30% and more specifically on mechanical pain, with our without radiation into the legs. In case of failure of traditional analgesia combining drugs and physical therapies, we can propose interventional pain relief. This involves a series of diagnostic blocks (medial branch blocks), followed by the treatment (radiofrequency ablation). This treatment remains purely symptomatic. A multidisciplinary approach with patient's physical reconditioning is therefore very important. PMID:27506065

  18. Proteomic analysis for the identification of serum diagnostic markers for joint hypermobility syndrome.

    PubMed

    Watanabe, Atsushi; Satoh, Kazumi; Maniwa, Tomoko; Matsumoto, Ken-Ichi

    2016-02-01

    Joint hypermobility syndrome (JHS) (also termed Ehlers-Danlos syndrome, hypermobility type) is a heritable connective tissue disorder which is characterized by generalized joint hypermobility, chronic pain, dizziness, fatigue, and minor skin changes. However, it has yet to be determined in patients with JHS whether specific genetic factors are involved in the risk of developing the disorder. Therefore, interventions have been limited to symptomatic treatments, and biomarkers for diagnosis and therapy have not yet been identified. In the present study, to identify potential serum biomarkers for JHS, we examined proteins with differential levels in sera from patients with JHS and in sera from control individuals using isobaric tags for relative and absolute quantitation (iTRAQ) labeling in combination with nano LC-MALDI-TOF/TOF-MS/MS followed by ProteinPilot analysis. In the sera of patients with JHS, a total of 106 proteins with differential levels were identified, and they were further narrowed down to 6 proteins (p<0.05, patient vs. control). Of the 6 proteins, proteins involved in the complement system including complement C1r subcomponent (C1R), vitronectin (VTN), complement component C9 (C9), and C4b-binding protein alpha chain (C4BPA) were identified as increased proteins in sera from patients with JHS compared with those in sera from controls. We confirmed increased levels of C1R and VTN in sera from patients with JHS by western blot analyses. The results indicate the possibility of a locally occurring inflammatory process in patients with JHS. PMID:26709396

  19. Facets of Subjectification

    ERIC Educational Resources Information Center

    Visconti, Jacqueline

    2013-01-01

    Subjectification, as the diachronic facet of subjectivity, has raised in the last two decades a number of interesting questions in grammaticalization and semantic change theory. In this paper I shall reflect on the nature and construal of subjectification, focusing on the question, formulated by Traugott (2010a, p. 58), "whether it is possible to…

  20. Optics Design for FACET

    SciTech Connect

    Nosochkov, Y.; Bane, K.; Bentson, L.; Erickson, R.; Hogan, M.J.; Li, N.; Seeman, J.; Seryi, A.; Spencer, Cherrill M.; Wittmer, W.; /SLAC

    2009-05-07

    FACET is a proposed facility at SLAC National Accelerator Laboratory. It will provide high energy, tightly focused and compressed electron and positron bunches for beam driven plasma wakefield acceleration research and other experiments. FACET will be built in the SLAC linac sector 20, where it will be separated from the LCLS located immediately downstream and will take advantage of the upstream 2 km linac for up to 23 GeV beam acceleration. FACET will also include an upgrade to linac sector 10, where a new e+ compressor chicane will be installed. The sector 20 will contain a new optics consisting of two chicanes for e+ and ebunch length compression, a final focus and an experimental line with a dump. The e+ and e- chicanes will allow the transport of e+ and ebunches together, their compression and proper positioning of e+ witness bunch behind the e- drive bunch at the plasma Interaction Point. The new optics will mostly use the existing SLAC magnets to minimize the project cost. Details of the FACET optics design and results of particle tracking simulations are presented.

  1. Beam Diagnostics for FACET

    SciTech Connect

    Li, S.Z.; Hogan, M.J.; /SLAC

    2011-08-19

    FACET, the Facility for Advanced Accelerator and Experimental Tests, is a new facility being constructed in sector 20 of the SLAC linac primarily to study beam driven plasma wakefield acceleration beginning in summer 2011. The nominal FACET parameters are 23GeV, 3nC electron bunches compressed to about 20 {micro}m long and focussed to about 10 {micro}m wide. Characterization of the beam-plasma interaction requires complete knowledge of the incoming beam parameters on a pulse-to-pulse basis. FACET diagnostics include Beam Position Monitors, Toroidal current monitors, X-ray and Cerenkov based energy spectrometers, optical transition radiation (OTR) profile monitors and coherent transition radiation (CTR) bunch length measurement systems. The compliment of beam diagnostics and their expected performance are reviewed. Beam diagnostic measurements not only provide valuable insights to the running and tuning of the accelerator but also are crucial for the PWFA experiments in particular. Beam diagnostic devices are being set up at FACET and will be ready for beam commissioning in summer 2011.

  2. The relationship between malocclusion, benign joint hypermobility syndrome, condylar position and TMD symptoms.

    PubMed

    Barrera-Mora, José Ma; Espinar Escalona, Eduardo; Abalos Labruzzi, Camilo; Llamas Carrera, José Ma; Ballesteros, Emilio Jiménez-Castellanos; Solano Reina, Enrique; Rocabado, Mariano

    2012-04-01

    The current study investigated the association between temporomandibular disorders, malocclusion patterns, benign joint hypermobility syndrome and the initial condylar position. One hundred sixty-two subjects were analyzed using the Rocabado Temporomandibular Pain Analysis; Helkimo Index parameters; the Carter-Wilkinson modified test; and a mounting cast with condylar position indicator registration (MPI). The study revealed a significant association between: 1. Delta H, skeletal pattern (p = 0.034); 2. Delta Y, transversal malocclusion (p = 0.04); 3. right and left, Delta Z, right and left posteroinferior synovial pain (p < 0.05); 4. hypermobility scale, gender (p < 0.001), malocclusion pattern (p = 0.021); 5. TMJ function impairment, gender (p = 0.043); 6. sagittal malocclusion pattern, right temporomandibular pain analysis joint (TPAJ) (p = 0.0034); 7. TMJ function impairment, left and right TPAJ (p = 0.007); and 8. mandibular motion, left and right TPAJ (p = 0.035, p = 0.015). The conclusion was that anterior crossbite and condylar displacements in the vertical plane are risk factors in developing TMJ symptoms.

  3. Is there any link between joint hypermobility and mitral valve prolapse in patients with fibromyalgia syndrome?

    PubMed

    Kozanoglu, Erkan; Coskun Benlidayi, Ilke; Eker Akilli, Rabia; Tasal, Abdurrahman

    2016-04-01

    The objective of the present study is to determine whether benign joint hypermobility syndrome (BJHS) modifies the risk of mitral valve prolapse (MVP) in patients with fibromyalgia (FM). Female patients fulfilling the 1990 American College of Rheumatology (ACR) diagnostic criteria for FM were included into the study. Joint hypermobility and BJHS were assessed using Beighton's scoring system and Brighton criteria, respectively. Echocardiograpic evaluation was performed in order to test the presence of MVP. Of the 75 female FM patients, 68.0 % (n = 51) and 20.0 % (n = 15) were diagnosed with BJHS and MVP, respectively. The frequencies of both MVP and BJHS seemed higher than the general population prevalence (p = 0.000 for both). The frequency of MVP was significantly higher in patients with BJHS than that in patients without BJHS (p = 0.028). In addition, BJHS was found to increase the risk of MVP approximately ninefold [odds ratio (OR) 8.7, 95 % confidence interval (CI) 1.1-70.7]. As a result, BJHS and MVP are both common in female patients with FM. Moreover, among the female patients with FM, those with BJHS are about nine times more prone to MVP than those without BJHS. Cardiologic assessment might be added to the routine follow-up strategies in FM patients with BJHS in order to exclude the cardiac pathologies, especially MVP. PMID:26216348

  4. IINCIDENCE OF ANKLE SPRAINS IN SOCCER PLAYERS WITH JOINT HYPERMOBILITY SYNDROME

    PubMed Central

    Vieira, Rodrigo Barreiros; Bertolini, Fabricio Melo; Vieira, Tallys Campos; Aguiar, Rodrigo Manso; Pinheiro, Guilherme Baldez; Lasmar, Rodrigo Campos Pace

    2015-01-01

    Objective: Eighty-three soccer players aged between 14 and 19 years, in the basic category of a professional soccer club in the city of Belo Horizonte, were followed up during the 2009 season. Methods: A prospective observational cohort study was conducted, in which these soccer players were divided randomly into two groups. The first consisted of individuals with joint hypermobility syndrome (JHS), totaling 22 players, and the second was a control group with 61 players without this syndrome, determined through a physical examinati. Results: Both groups were studied with regard to incidence of ankle sprains. At the end of this period, the data were compiled and statistical analysis was performed. A total of 43 cases of ankle injury due to sprains were recorded, of which nine episodes were in players with JHS, thus making p = 0.106. The significance level was 5%. Conclusion: We were able to conclude that in our study there was insufficient evidence to assert that there is an association with increased incidence of ankle sprains among patients with JHS. PMID:27047888

  5. Craniovertebral Junction Instability: A Review of Facts about Facets

    PubMed Central

    2015-01-01

    Craniovertebral junction surgery involves an appropriate philosophical, biomechanical and anatomical understanding apart from high degree of technical skill and ability of controlling venous and arterial bleeding. The author presents his 30-year experience with treating complex craniovertebral junction instability related surgical issues. The facets of atlas and axis form the primary site of movements at the craniovertebral junction. All craniovertebral junction instability is essentially localized to the atlantoaxial facet joint. Direct manipulation and fixation of the facets forms the basis of treatment for instability. PMID:26240728

  6. Targeted deletion of collagen V in tendons and ligaments results in a classic Ehlers-Danlos syndrome joint phenotype.

    PubMed

    Sun, Mei; Connizzo, Brianne K; Adams, Sheila M; Freedman, Benjamin R; Wenstrup, Richard J; Soslowsky, Louis J; Birk, David E

    2015-05-01

    Collagen V mutations underlie classic Ehlers-Danlos syndrome, and joint hypermobility is an important clinical manifestation. We define the function of collagen V in tendons and ligaments, as well as the role of alterations in collagen V expression in the pathobiology in classic Ehlers-Danlos syndrome. A conditional Col5a1(flox/flox) mouse model was bred with Scleraxis-Cre mice to create a targeted tendon and ligament Col5a1-null mouse model, Col5a1(Δten/Δten). Targeting was specific, resulting in collagen V-null tendons and ligaments. Col5a1(Δten/Δten) mice demonstrated decreased body size, grip weakness, abnormal gait, joint laxity, and early-onset osteoarthritis. These gross changes were associated with abnormal fiber organization, as well as altered collagen fibril structure with increased fibril diameters and decreased fibril number that was more severe in a major joint stabilizing ligament, the anterior cruciate ligament (ACL), than in the flexor digitorum longus tendon. The ACL also had a higher collagen V content than did the flexor digitorum longus tendon. The collagen V-null ACL and flexor digitorum longus tendon both had significant alterations in mechanical properties, with ACL exhibiting more severe changes. The data demonstrate critical differential regulatory roles for collagen V in tendon and ligament structure and function and suggest that collagen V regulatory dysfunction is associated with an abnormal joint phenotype, similar to the hypermobility phenotype in classic Ehlers-Danlos syndrome.

  7. Targeted deletion of collagen V in tendons and ligaments results in a classic Ehlers-Danlos syndrome joint phenotype.

    PubMed

    Sun, Mei; Connizzo, Brianne K; Adams, Sheila M; Freedman, Benjamin R; Wenstrup, Richard J; Soslowsky, Louis J; Birk, David E

    2015-05-01

    Collagen V mutations underlie classic Ehlers-Danlos syndrome, and joint hypermobility is an important clinical manifestation. We define the function of collagen V in tendons and ligaments, as well as the role of alterations in collagen V expression in the pathobiology in classic Ehlers-Danlos syndrome. A conditional Col5a1(flox/flox) mouse model was bred with Scleraxis-Cre mice to create a targeted tendon and ligament Col5a1-null mouse model, Col5a1(Δten/Δten). Targeting was specific, resulting in collagen V-null tendons and ligaments. Col5a1(Δten/Δten) mice demonstrated decreased body size, grip weakness, abnormal gait, joint laxity, and early-onset osteoarthritis. These gross changes were associated with abnormal fiber organization, as well as altered collagen fibril structure with increased fibril diameters and decreased fibril number that was more severe in a major joint stabilizing ligament, the anterior cruciate ligament (ACL), than in the flexor digitorum longus tendon. The ACL also had a higher collagen V content than did the flexor digitorum longus tendon. The collagen V-null ACL and flexor digitorum longus tendon both had significant alterations in mechanical properties, with ACL exhibiting more severe changes. The data demonstrate critical differential regulatory roles for collagen V in tendon and ligament structure and function and suggest that collagen V regulatory dysfunction is associated with an abnormal joint phenotype, similar to the hypermobility phenotype in classic Ehlers-Danlos syndrome. PMID:25797646

  8. Facet theory applied to the construction and validation of the Aachen Aphasia Test.

    PubMed

    Willmes, K; Poeck, K; Weniger, D; Huber, W

    1983-03-01

    The linguistic performance of 120 aphasic patients of the four standard syndromes assessed by the Aachen Aphasia Test (AAT) is analyzed by a nonmetric (ordinal) multidimensional scaling procedure (Smallest Space Analysis, SSA1). The linguistic structure of the test items is characterized within the framework of L. Guttman's facet theory. Three systematic components (facets) are discerned: linguistic modality, unit, and regularity. Properties of the facets as well as their relations are assessed and tested empirically by analyzing the interrelations among different items or sets of items. The spatial configurations obtained by the scaling procedure fit only partially the expectations derived from the facet-theory model. The modality facet was found to have a strong overriding influence on the aphasic test performance. The facets unit and regularity were only found for the most rigorously designed subtests. Written Language and Comprehension. The results suggest the introduction of a new combined facet linguistic complexity which reflects the dependency of the facets regularity and unit.

  9. FACET Emittance Growth

    SciTech Connect

    Frederico, J; Hogan, M.J.; Nosochkov, Y.; Litos, M.D.; Raubenheimer, T.; /SLAC

    2011-04-05

    FACET, the Facility for Advanced Accelerator and Experimental Tests, is a new facility being constructed in sector 20 of the SLAC linac primarily to study beam driven plasma wakefield acceleration. The FACET beamline consists of a chicane and final focus system to compress the 23 GeV, 3.2 nC electron bunches to {approx}20 {micro}m long and {approx}10 {micro}m wide. Simulations of the FACET beamline indicate the short-duration and large, 1.5% rms energy spread beams may suffer a factor of four emittance growth from a combination of chromaticity, incoherent synchrotron radiation (ISR), and coherent synchrotron radiation (CSR). Emittance growth is directly correlated to head erosion in plasma wakefield acceleration and is a limiting factor in single stage performance. Studies of the geometric, CSR, and ISR components are presented. Numerical calculation of the rms emittance can be overwhelmed by long tails in the simulated phase space distributions; more useful definitions of emittance are given. A complete simulation of the beamline is presented as well, which agrees with design specifications.

  10. Hypermobility and joint hypermobility syndrome in Brazilian students and teachers of ballet dance.

    PubMed

    Sanches, S B; Oliveira, G M; Osório, F L; Crippa, J A S; Martín-Santos, R

    2015-04-01

    The current literature has been discussing the risks and benefits of joint hypermobility (JHM) for careers in ballet This study aimed to evaluate the prevalence of JHM and joint hypermobility syndrome (JHS) in a group of ballet teachers and students, looking both at aspects related to the flexibility required to dance, as at the risk of injuries when hypermobility is associated with other symptoms, in the case of JHS. We evaluated ballet teachers and ballet students, with age ranging from 18 to 40 years. All participants completed identification and sociodemographic questionnaires and underwent a physical examination. JHM was assessed using the Beighton score with goniometry. Symptoms of JHS were evaluated according to the Brighton criteria. Final sample consisted of 77 participants, being 44 ballet students and 33 ballet teachers. The prevalence of JHM in the sample as a whole was 58 %. Teachers and students had no significant differences regarding the prevalence of JHM (p = 0.74) (OR 1.21; 95 % CI 0.48-3.07). However, the prevalence of JHS was significantly different (p = 0.04) between students (16 %) and teachers (36 %). Teachers were three times more likely than student to have JHS (OR 3.02; 95 % CI 1.03-8.85). Teachers and students also presented differences in the frequency of specific items of Beighton score and Brighton criteria. These data provide elements to discuss the relationship between hypermobility, ballet technique and selection for dance, suggesting that dancers with JHS could find in ballet teaching an alternative to maintain professional activity with dance, while remaining protected from the higher risk of injury that professional dancers may be exposed to. PMID:25218649

  11. Living with joint hypermobility syndrome: patient experiences of diagnosis, referral and self-care

    PubMed Central

    Terry, Rohini H; Rimes, Katharine A; Clark, Carol J; Simmonds, Jane V; Horwood, Jeremy P

    2015-01-01

    Background. Musculoskeletal problems are common reasons for seeking primary health care. It has been suggested that many people with ‘everyday’ non-inflammatory musculoskeletal problems may have undiagnosed joint hypermobility syndrome (JHS), a complex multi-systemic condition. JHS is characterized by joint laxity, pain, fatigue and a wide range of other symptoms. Physiotherapy is usually the preferred treatment option for JHS, although diagnosis can be difficult. The lived experience of those with JHS requires investigation. Objective. The aim of the study was to examine patients’ lived experience of JHS, their views and experiences of JHS diagnosis and management. Methods. Focus groups in four locations in the UK were convened, involving 25 participants with a prior diagnosis of JHS. The focus groups were audio recorded, fully transcribed and analysed using the constant comparative method to inductively derive a thematic account of the data. Results. Pain, fatigue, proprioception difficulties and repeated cycles of injury were among the most challenging features of living with JHS. Participants perceived a lack of awareness of JHS from health professionals and more widely in society and described how diagnosis and access to appropriate health-care services was often slow and convoluted. Education for patients and health professionals was considered to be essential. Conclusions. Timely diagnosis, raising awareness and access to health professionals who understand JHS may be particularly instrumental in helping to ameliorate symptoms and help patients to self-manage their condition. Physiotherapists and other health professionals should receive training to provide biopsychosocial support for people with this condition. PMID:25911504

  12. Quality of life, unmet needs, and iatrogenic injuries in rehabilitation of patients with Ehlers-Danlos Syndrome hypermobility type/Joint Hypermobility Syndrome.

    PubMed

    Bovet, Claire; Carlson, Matthew; Taylor, Matthew

    2016-08-01

    Ehlers-Danlos Syndrome, hypermobility type (EDS-HT) and the joint hypermobility syndrome (JHS) are connective tissue disorders that form an overlapping clinical syndrome and are associated with frequent medical visits and substantial morbidity. EDS-HT/JHS-associated pain correlates with poor quality of life. While physical therapy is the recommended treatment for EDS-HT/JHS, little is known about therapy-related patient experiences and iatrogenic injuries. We studied 38 adult EDS-HT/JHS patients, eliciting health-related quality of life (HRQoL) from 28 patients through the RAND SF-36 questionnaire. We also explored physical therapy experiences through focus groups with 13 patients. Our patients displayed poor HRQoL, with 71% reporting worse health over the past year. SF-36 scores were significantly lower than the scores of the average American population (P < 0.001 for 8 of 10 categories assessed), but were comparable to EDS-HT/JHS populations in Belgium, the Netherlands, Sweden, and Italy. Focus groups identified factors associated with: negative past physical therapy experiences, iatrogenic joint injuries, positive treatment experiences, and unmet rehabilitation needs. This group of EDS-HT/JHS patients has significant decrements in HRQoL and many unmet treatment needs, as well as a risk for iatrogenic injuries. We identify several approaches to help meet patients' needs and improve joint rehabilitation in patients with EDS-HT/JHS. © 2016 Wiley Periodicals, Inc.

  13. Quality of life, unmet needs, and iatrogenic injuries in rehabilitation of patients with Ehlers-Danlos Syndrome hypermobility type/Joint Hypermobility Syndrome.

    PubMed

    Bovet, Claire; Carlson, Matthew; Taylor, Matthew

    2016-08-01

    Ehlers-Danlos Syndrome, hypermobility type (EDS-HT) and the joint hypermobility syndrome (JHS) are connective tissue disorders that form an overlapping clinical syndrome and are associated with frequent medical visits and substantial morbidity. EDS-HT/JHS-associated pain correlates with poor quality of life. While physical therapy is the recommended treatment for EDS-HT/JHS, little is known about therapy-related patient experiences and iatrogenic injuries. We studied 38 adult EDS-HT/JHS patients, eliciting health-related quality of life (HRQoL) from 28 patients through the RAND SF-36 questionnaire. We also explored physical therapy experiences through focus groups with 13 patients. Our patients displayed poor HRQoL, with 71% reporting worse health over the past year. SF-36 scores were significantly lower than the scores of the average American population (P < 0.001 for 8 of 10 categories assessed), but were comparable to EDS-HT/JHS populations in Belgium, the Netherlands, Sweden, and Italy. Focus groups identified factors associated with: negative past physical therapy experiences, iatrogenic joint injuries, positive treatment experiences, and unmet rehabilitation needs. This group of EDS-HT/JHS patients has significant decrements in HRQoL and many unmet treatment needs, as well as a risk for iatrogenic injuries. We identify several approaches to help meet patients' needs and improve joint rehabilitation in patients with EDS-HT/JHS. © 2016 Wiley Periodicals, Inc. PMID:27273746

  14. Re-writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

    PubMed

    Castori, Marco; Morlino, Silvia; Celletti, Claudia; Ghibellini, Giulia; Bruschini, Michela; Grammatico, Paola; Blundo, Carlo; Camerota, Filippo

    2013-12-01

    Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping connective tissue disorders characterized by chronic/recurrent pain, joint instability complications, and minor skin changes. Fatigue and headache are also common, although are not yet considered diagnostic criteria. JHS/EDS-HT is a unexpectedly common condition that remains underdiagnosed by most clinicians and pain specialists. This results in interventions limited to symptomatic and non-satisfactory treatments, lacking reasonable pathophysiologic rationale. In this manuscript the fragmented knowledge on pain, fatigue, and headache in JHS/EDS is presented with review of the available published information and a description of the clinical course by symptoms, on the basis of authors' experience. Pathogenic mechanisms are suggested through comparisons with other functional somatic syndromes (e.g., chronic fatigue syndrome, fibromyalgia, and functional gastrointestinal disorders). The re-writing of the natural history of JHS/EDS-HT is aimed to raise awareness among clinical geneticists and specialists treating chronic pain conditions about pain and other complications of JHS/EDS-HT. Symptoms' clustering by disease stage is proposed to investigate both the molecular causes and the symptoms management of JHS/EDS-HT in future studies. PMID:24254847

  15. Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders.

    PubMed

    Colombi, Marina; Dordoni, Chiara; Chiarelli, Nicola; Ritelli, Marco

    2015-03-01

    Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is an evolving and protean disorder mostly recognized by generalized joint hypermobility and without a defined molecular basis. JHS/EDS-HT also presents with other connective tissue features affecting a variety of structures and organs, such as skin, eye, bone, and internal organs. However, most of these signs are present in variable combinations and severity in many other heritable connective tissue disorders. Accordingly, JHS/EDS-HT is an "exclusion" diagnosis which needs the absence of any consistent feature indicative of other partially overlapping connective tissue disorders. While both Villefranche and Brighton criteria include such an exclusion as a mandatory item, a systematic approach for reaching a stringent clinical diagnosis of JHS/EDS-HT is still lacking. The absence of a consensus on the diagnostic approach to JHS/EDS-HT concerning its clinical boundaries with similar conditions contribute to limit our actual understanding of the pathologic and molecular bases of this disorder. In this review, we revise the differential diagnosis of JHS/EDS-HT with those heritable connective tissue disorders which show a significant overlap with the former and mostly include EDS classic, vascular and kyphoscoliotic types, osteogenesis imperfecta, Marfan syndrome, Loeys-Dietz syndrome, arterial tortuosity syndrome, and lateral meningocele syndrome. A diagnostic flow chart is also offered with the attempt to support the less experienced clinician in stringently recognizing JHS/EDS-HT and stimulate the debate in the scientific community for both management and research purposes. PMID:25821090

  16. Is pain the only symptom in patients with benign joint hypermobility syndrome?

    PubMed

    Albayrak, İlknur; Yilmaz, Halim; Akkurt, Halil Ekrem; Salli, Ali; Karaca, Gülten

    2015-09-01

    The aims of this study were to evaluate pain, depression level, fatigue, sleep, and quality of life (QoL) among patients with benign joint hypermobility syndrome (BJHS) and to compare their results with those of healthy controls. The study involved 115 patients and 114 healthy volunteers. Pain level was rated using visual analogue scale (VAS) for all patients. Depression level, fatigue, sleep quality, and QoL of all the participants were evaluated by the Beck Depression Inventory (BDI), the Checklist Individual Strength (CIS), the Pittsburgh Sleep Quality Index (PSQI), and the Short Form-36 (SF-36), respectively. VAS value was 6.29 ± 0.94 in the patient group. Comparison of two groups showed that there were statistically significant differences between the patient group and the control group with respect to BDI, total CIS, PSQI scores, SF-36 subscales (physical function, role physical, bodily pain, general health, role emotional, and mental health), and mental component summary (p < 0.001). While pain is the predominant symptom among BJHS patients, depression, fatigue, impaired sleep, and QoL also commonly occur. Thus, all of these components should be taken into account when assessing patients with BJHS. PMID:24744155

  17. Short-term effects of kinesio tape on joint position sense, isokinetic measurements, and clinical parameters in patellofemoral pain syndrome.

    PubMed

    Kurt, Emine Eda; Büyükturan, Öznur; Erdem, Hatice Rana; Tuncay, Figen; Sezgin, Hicabi

    2016-07-01

    [Purpose] To evaluate the short-term effects of kinesio tape on joint position sense, isokinetic measurements, kinesiophobia, symptoms, and functional limitations in patients with patellofemoral pain syndrome. [Subjects and Methods] A total of 90 patients (112 knees) with patellofemoral pain syndrome were randomized into a kinesio tape group (n=45) or placebo kinesio tape group (n=45). Baseline isokinetic quadriceps muscle tests and measurements of joint position sense were performed in both groups. Pain was measured with a Visual Analog Scale, kinesiophobia with the Tampa kinesiophobia scale, and symptoms and functional limitations with the Kujala pain scale. Measurements were repeated 2 days after kinesio tape application. [Results] No differences were found between baseline isokinetic muscle measurements and those taken 2 days after application. However, significant improvements were observed in the kinesio tape group, with regard to joint position sense, pain, kinesiophobia, symptoms, and functional limitations after treatment. Examination of the differences between pre- and post-treatment values in both groups revealed that the kinesio tape group demonstrated greater improvements compared to the placebo kinesio tape group. [Conclusion] Although short-term kinesio tape application did not increase hamstring muscle strength, it may have improved joint position sense, pain, kinesiophobia, symptoms, and daily limitations. PMID:27512259

  18. Short-term effects of kinesio tape on joint position sense, isokinetic measurements, and clinical parameters in patellofemoral pain syndrome.

    PubMed

    Kurt, Emine Eda; Büyükturan, Öznur; Erdem, Hatice Rana; Tuncay, Figen; Sezgin, Hicabi

    2016-07-01

    [Purpose] To evaluate the short-term effects of kinesio tape on joint position sense, isokinetic measurements, kinesiophobia, symptoms, and functional limitations in patients with patellofemoral pain syndrome. [Subjects and Methods] A total of 90 patients (112 knees) with patellofemoral pain syndrome were randomized into a kinesio tape group (n=45) or placebo kinesio tape group (n=45). Baseline isokinetic quadriceps muscle tests and measurements of joint position sense were performed in both groups. Pain was measured with a Visual Analog Scale, kinesiophobia with the Tampa kinesiophobia scale, and symptoms and functional limitations with the Kujala pain scale. Measurements were repeated 2 days after kinesio tape application. [Results] No differences were found between baseline isokinetic muscle measurements and those taken 2 days after application. However, significant improvements were observed in the kinesio tape group, with regard to joint position sense, pain, kinesiophobia, symptoms, and functional limitations after treatment. Examination of the differences between pre- and post-treatment values in both groups revealed that the kinesio tape group demonstrated greater improvements compared to the placebo kinesio tape group. [Conclusion] Although short-term kinesio tape application did not increase hamstring muscle strength, it may have improved joint position sense, pain, kinesiophobia, symptoms, and daily limitations.

  19. Short-term effects of kinesio tape on joint position sense, isokinetic measurements, and clinical parameters in patellofemoral pain syndrome

    PubMed Central

    Kurt, Emine Eda; Büyükturan, Öznur; Erdem, Hatice Rana; Tuncay, Figen; Sezgin, Hicabi

    2016-01-01

    [Purpose] To evaluate the short-term effects of kinesio tape on joint position sense, isokinetic measurements, kinesiophobia, symptoms, and functional limitations in patients with patellofemoral pain syndrome. [Subjects and Methods] A total of 90 patients (112 knees) with patellofemoral pain syndrome were randomized into a kinesio tape group (n=45) or placebo kinesio tape group (n=45). Baseline isokinetic quadriceps muscle tests and measurements of joint position sense were performed in both groups. Pain was measured with a Visual Analog Scale, kinesiophobia with the Tampa kinesiophobia scale, and symptoms and functional limitations with the Kujala pain scale. Measurements were repeated 2 days after kinesio tape application. [Results] No differences were found between baseline isokinetic muscle measurements and those taken 2 days after application. However, significant improvements were observed in the kinesio tape group, with regard to joint position sense, pain, kinesiophobia, symptoms, and functional limitations after treatment. Examination of the differences between pre- and post-treatment values in both groups revealed that the kinesio tape group demonstrated greater improvements compared to the placebo kinesio tape group. [Conclusion] Although short-term kinesio tape application did not increase hamstring muscle strength, it may have improved joint position sense, pain, kinesiophobia, symptoms, and daily limitations. PMID:27512259

  20. The efficacy of acupuncture and decompression splints in the treatment of temporomandibular joint pain-dysfunction syndrome

    PubMed Central

    Yu-Lu, Si-Lei; Zhang, Bingxin; Bocanegra-Pérez, Sacramento; Durán-Moreno, David; López-Márquez, Adriana; Knezevic, Milan; Castellano-Navarro, José-María; Limiñana-Cañal, José-María

    2012-01-01

    Objectives: The goal of the present study was to evaluate the results of applying acupuncture or occlusal decompression splints in the treatment of patients diagnosed with the temporomandibular joint pain-dysfunction syndrome. Design of the study: We conducted a randomized clinical trial including 20 patients to whom the mentioned treatments were applied. Results were evaluated through an analogue pain scale, measurements of mouth opening and jaw lateral deviation in millimetres, and assessment of sensitivity to pressure on different points: preauricular, masseter muscle, temporal muscle and trapezius. Parameters were evaluated before and 30 days after the treatment. For standardized pressure, we used a pressure algometer. Results: Patients treated with decompression splints showed reductions in subjective pain and pain upon pressure on temporal, masseter and trapezius muscles, as well as increased mouth opening after the treatment. Patients treated with acupuncture showed pain reduction in the short term and improvements in all of the evaluated para-meters (stronger pressure was required to produce pain; mouth opening was improved). Conclusion: Acupuncture was an effective complement and/or an acceptable alternative to decompression splints in the treatment of myofascial pain and temporomandibular joint pain-dysfunction syndrome. Key words:Temporomandibular joint, temporomandibular dysfunction, acupuncture, decompression splint, arthralgia, myofascial pain, joint palpation. PMID:22549668

  1. Low-level laser therapy of myofascial pain syndromes of patients with osteoarthritis of knee and hip joints

    NASA Astrophysics Data System (ADS)

    Gasparyan, Levon V.

    2001-04-01

    The purpose of the given research is the comparison of efficiency of conventional treatment of myofascial pain syndromes of patients with osteoarthritis (OA) of hip and knee joints and therapy with additional application of low level laser therapy (LLLT) under dynamic control of clinical picture, rheovasographic, electromyographic examinations, and parameters of peroxide lipid oxidation. The investigation was made on 143 patients with OA of hip and knee joints. Patients were randomized in 2 groups: basic group included 91 patients, receiving conventional therapy with a course of LLLT, control group included 52 patients, receiving conventional treatment only. Transcutaneous ((lambda) equals 890 nm, output peak power 5 W, frequency 80 - 3000 Hz) and intravenous ((lambda) equals 633 nm, output 2 mW in the vein) laser irradiation were used for LLLT. Studied showed, that clinical efficiency of LLLT in the complex with conventional treatment of myofascial pain syndromes at the patients with OA is connected with attenuation of pain syndrome, normalization of parameters of myofascial syndrome, normalization of the vascular tension and parameters of rheographic curves, as well as with activation of antioxidant protection system.

  2. Optics Tuning Knobs for Facet

    SciTech Connect

    Nosochkov, Yuri; Hogan, Mark J.; Wittmer, Walter; /SLAC

    2011-06-02

    FACET is a new facility under construction at the SLAC National Accelerator Laboratory. The FACET beam line is designed to provide 23 GeV tightly focused and compressed electron and positron bunches for beam driven plasma wakefield acceleration research and other experiments. Achieving optimal beam parameters for various experimental conditions requires the optics capability for tuning in a sufficiently wide range. This will be achieved by using optics tuning systems (knobs). Design of such systems for FACET is discussed.

  3. How do people with chronically painful joint hypermobility syndrome make decisions about activity?

    PubMed Central

    Schmidt, Anne; Corcoran, Kelley; Grahame, Rodney

    2015-01-01

    Background: The model of activity avoidance prompted by fear of increased pain and/or harm dominates understanding and research into activity limitation in chronic pain. Yet, the accounts of people with chronic pain on decisions about activity limitation are rarely heard beyond the confines of fear and avoidance questionnaires. Methods: We used semi-structured interviews to explore the decisions of 11 women attending a pain management clinic with chronically painful Joint Hypermobility Syndrome (JHS). Results: Six themes emerged from Interpretative Phenomenological Analysis: the overall aim of keeping pain to a manageable level, considering whether the planned activity was worth it and, running through all judgements, the influence of pain intensity. The decision was tipped towards avoidance by unpredictability of pain and by high emotional cost and towards going ahead with the activity by the wish to exert control and by low emotional cost. Many accounts described a specifiable cost–benefit analysis of individual decisions, weighing the importance of each activity against its potential aversive consequences, which only in a minority of cases was dominated by fear of pain or injury. Conclusion: Assumptions of fear as the basis of activity avoidance should not be used uncritically in clinical settings. Decisions about activity should explore beyond pain expectancy, incorporating goals, values, and decision processes. Summary points The model of fear of pain or re/injury and associated avoidance, an important insight that has generated effective therapeutic interventions, risks being over-applied and assumed rather than demonstrated. Patients’ own accounts, using qualitative analysis of interview in 11 women with long term chronic pain associated with joint hypermobility, give a more nuanced description of complex decision-making around activity. While a few activities were unquestionably avoided because of such fears, others were undertaken when benefits

  4. The Many Facets of PISA

    ERIC Educational Resources Information Center

    Berliner, David C.

    2015-01-01

    Trying to understand PISA is analogous to the parable of the blind men and the elephant. There are many facets of the PISA program, and thus many ways to both applaud and critique this ambitious international program of assessment that has gained enormous importance in the crafting of contemporary educational policy. One of the facets discussed in…

  5. Faceted Taxonomy-Based Sources

    NASA Astrophysics Data System (ADS)

    Tzitzikas, Yannis

    The objective of this chapter is to explain the underlying mathematical structure of faceted taxonomy-based sources and to provide some common notions and notations that are used in some parts of the book. Subsequently, and on the basis of the introduced formalism, this chapter describes the interaction between a user and an information source that supports dynamic taxonomies and faceted search.

  6. The feasibility of a randomised controlled trial of physiotherapy for adults with joint hypermobility syndrome.

    PubMed Central

    Palmer, Shea; Cramp, Fiona; Clark, Emma; Lewis, Rachel; Brookes, Sara; Hollingworth, William; Welton, Nicky; Thom, Howard; Terry, Rohini; Rimes, Katharine A; Horwood, Jeremy

    2016-01-01

    BACKGROUND Joint hypermobility syndrome (JHS) is a heritable disorder associated with laxity and pain in multiple joints. Physiotherapy is the mainstay of treatment, but there is little research investigating its clinical effectiveness. OBJECTIVES To develop a comprehensive physiotherapy intervention for adults with JHS; to pilot the intervention; and to conduct a pilot randomised controlled trial (RCT) to determine the feasibility of conducting a future definitive RCT. DESIGN Patients' and health professionals' perspectives on physiotherapy for JHS were explored in focus groups (stage 1). A working group of patient research partners, clinicians and researchers used this information to develop the physiotherapy intervention. This was piloted and refined on the basis of patients' and physiotherapists' feedback (stage 2). A parallel two-arm pilot RCT compared 'advice' with 'advice and physiotherapy' (stage 3). Random allocation was via an automated randomisation service, devised specifically for the study. Owing to the nature of the interventions, it was not possible to blind clinicians or patients to treatment allocation. SETTING Stage 1 - focus groups were conducted in four UK locations. Stages 2 and 3 - piloting of the intervention and the pilot RCT were conducted in two UK secondary care NHS trusts. PARTICIPANTS Stage 1 - patient focus group participants (n = 25, three men) were aged > 18 years, had a JHS diagnosis and had received physiotherapy within the preceding 12 months. The health professional focus group participants (n = 16, three men; 14 physiotherapists, two podiatrists) had experience of managing JHS. Stage 2 - patient participants (n = 8) were aged > 18 years, had a JHS diagnosis and no other musculoskeletal conditions causing pain. Stage 3 - patient participants for the pilot RCT (n = 29) were as for stage 2 but the lower age limit was 16 years. INTERVENTION For the pilot RCT (stage 3) the advice intervention was a one

  7. Facet Control of Gold Nanorods.

    PubMed

    Zhang, Qingfeng; Han, Lili; Jing, Hao; Blom, Douglas A; Lin, Ye; Xin, Huolin L; Wang, Hui

    2016-02-23

    While great success has been achieved in fine-tuning the aspect ratios and thereby the plasmon resonances of cylindrical Au nanorods, facet control with atomic level precision on the highly curved nanorod surfaces has long been a significantly more challenging task. The intrinsic structural complexity and lack of precise facet control of the nanorod surfaces remain the major obstacles for the atomic-level elucidation of the structure-property relationships that underpin the intriguing catalytic performance of Au nanorods. Here we demonstrate that the facets of single-crystalline Au nanorods can be precisely tailored using cuprous ions and cetyltrimethylammonium bromide as a unique pair of surface capping competitors to guide the particle geometry evolution during nanorod overgrowth. By deliberately maneuvering the competition between cuprous ions and cetyltrimethylammonium bromide, we have been able to create, in a highly controllable and selective manner, an entire family of nanorod-derived anisotropic multifaceted geometries whose surfaces are enclosed by specific types of well-defined high-index and low-index facets. This facet-controlled nanorod overgrowth approach also allows us to fine-tune the particle aspect ratios while well-preserving all the characteristic facets and geometric features of the faceted Au nanorods. Taking full advantage of the combined structural and plasmonic tunability, we have further studied the facet-dependent heterogeneous catalysis on well-faceted Au nanorods using surface-enhanced Raman spectroscopy as an ultrasensitive spectroscopic tool with unique time-resolving and molecular finger-printing capabilities. PMID:26795706

  8. Facet control of gold nanorods

    DOE PAGESBeta

    Zhang, Qingfeng; Han, Lili; Jing, Hao; Blom, Douglas A.; Lin, Ye; Xin, Huolin L.; Wang, Hui

    2016-01-21

    While great success has been achieved in fine-tuning the aspect ratios and thereby the plasmon resonances of cylindrical Au nanorods, facet control with atomic level precision on the highly curved nanorod surfaces has long been a significantly more challenging task. The intrinsic structural complexity and lack of precise facet control of the nanorod surfaces remain the major obstacles for the atomic-level elucidation of the structure–property relationships that underpin the intriguing catalytic performance of Au nanorods. Here we demonstrate that the facets of single-crystalline Au nanorods can be precisely tailored using cuprous ions and cetyltrimethylammonium bromide as a unique pair ofmore » surface capping competitors to guide the particle geometry evolution during nanorod overgrowth. By deliberately maneuvering the competition between cuprous ions and cetyltrimethylammonium bromide, we have been able to create, in a highly controllable and selective manner, an entire family of nanorod-derived anisotropic multifaceted geometries whose surfaces are enclosed by specific types of well-defined high-index and low-index facets. This facet-controlled nanorod overgrowth approach also allows us to fine-tune the particle aspect ratios while well-preserving all the characteristic facets and geometric features of the faceted Au nanorods. Furthermore, taking full advantage of the combined structural and plasmonic tunability, we have further studied the facet-dependent heterogeneous catalysis on well-faceted Au nanorods using surface-enhanced Raman spectroscopy as an ultrasensitive spectroscopic tool with unique time-resolving and molecular finger-printing capabilities.« less

  9. Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach.

    PubMed

    Castori, Marco; Morlino, Silvia; Celletti, Claudia; Celli, Mauro; Morrone, Aldo; Colombi, Marina; Camerota, Filippo; Grammatico, Paola

    2012-08-01

    Joint hypermobility syndrome (JHS), or Ehlers-Danlos syndrome (EDS) hypermobility type (EDS-HT), is a underdiagnosed heritable connective tissue disorder characterized by generalized joint hypermobility and a wide range of visceral, pelvic, neurologic, and cognitive dysfunctions. Deterioration of quality of life is mainly associated with pain and fatigue. Except for the recognized effectiveness of physiotherapy for some musculoskeletal features, there are no standardized guidelines for the assessment and treatment of pain and fatigue. In this work, a practical classification of pain presentations and factors contributing in generating painful sensations in JHS/EDS-HT is proposed. Pain can be topographically classified in articular limb (acute/subacute and chronic), muscular limb (myofascial and fibromyalgia), neuropathic limb, back/neck, abdominal and pelvic pain, and headache. For selected forms of pain, specific predisposing characteristics are outlined. Fatigue appears as the result of multiple factors, including muscle weakness, respiratory insufficiency, unrefreshing sleep, dysautonomia, intestinal malabsorption, reactive depression/anxiety, and excessive use of analgesics. A set of lifestyle recommendations to instruct patients as well as specific investigations aimed at characterizing pain and fatigue are identified. Available treatment options are discussed in the set of a structured multidisciplinary approach based on reliable outcome tools. PMID:22786715

  10. The effects of neuromuscular taping on gait walking strategy in a patient with joint hypermobility syndrome/Ehlers–Danlos syndrome hypermobility type

    PubMed Central

    Camerota, Filippo; Galli, Manuela; Celletti, Claudia; Ancillao, Andrea; Blow, David; Albertini, Giorgio

    2015-01-01

    Objective: In this case study, biomechanical alterations induced by neuromuscular taping (NMT) were quantified, during walking, in a patient with joint hypermobility syndrome/Ehlers–Danlos syndrome hypermobility type (JHS/EDS-HT). Methods: A female JHS/EDS-HT patient underwent NMT applications over the low back spine and bilaterally to the knee. Quantitative gait analyses were collected before the NMT application and at the end of the treatment (2 weeks after the first application of NMT). Results: At the end of treatment following the NMT application, left step length showed improvements in cadence and velocity, the left knee showed a reduction in its flexed position at initial contact, and the right ankle joint improved its position at initial contact and in the swing phase. Improvements were also found in kinetics, in terms of the ankle moment and power. Conclusions: Results show that NMT seems to be a promising low-cost intervention for improving gait strategy in patients with JHS/EDS-HT. Further investigations are needed to assess the effects of this treatment intervention on pathological symptoms. PMID:25649985

  11. Pre- and post-operative comorbidities in idiopathic carpal tunnel syndrome: cervical arthritis, basal joint arthritis of the thumb, and trigger digit.

    PubMed

    Kim, J H; Gong, H S; Lee, H J; Lee, Y H; Rhee, S H; Baek, G H

    2013-01-01

    We retrospectively reviewed 633 hands in 362 patients who had idiopathic carpal tunnel syndrome and underwent carpal tunnel release between 1999 and 2009. Electrophysiological studies and simple radiographs of the wrist, cervical spine, and basal joint of the thumb were routinely checked, and patients were also assessed for the presence of trigger digit or de Quervain's disease before and after surgery. Among 362 patients, cervical arthritis was found in 253 patients (70%), and C5-C6 arthritis was the most common site. Basal joint arthritis of the thumb was observed in 216 (34%) of the 633 hands. Trigger digit or de Quervain's disease was observed in 85 of the 633 hands (13%) before surgery, and developed in 67 hands (11%) after surgery. Cervical arthritis, basal joint arthritis, and trigger digit commonly coexist with idiopathic carpal tunnel syndrome. Patient education about these disorders is very important when they coexist with idiopathic carpal tunnel syndrome.

  12. SLAC Linac Preparations for FACET

    SciTech Connect

    Erickson, R.; Bentson, L.; Kharakh, D.; Owens, A.; Schuh, P.; Seeman, J.; Sheppard, J.C.; Stanek, M.; Wittmer, W.; Yocky, G.; Wienands, U.; /SLAC

    2011-02-07

    The SLAC 3km linear electron accelerator has been cut at the two-thirds point to provide beams to two independent programs. The last third provides the electron beam for the Linac Coherent Light Source (LCLS), leaving the first two-thirds available for FACET, the new experimental facility for accelerator science and test beams. In this paper, we describe this separation and projects to prepare the linac for the FACET experimental program.

  13. Dynamic of Faceted Colloidal Clusters

    NASA Astrophysics Data System (ADS)

    Sindoro, Melinda; Jee, Ah-Young; Yu, Changqian; Granick, Steve

    2014-03-01

    We study the emulsion induced clustering of faceted metal organic frameworks (MOFs) and their dynamics. Our approach to anisotropic building block is through the rational synthesis of water stable and highly uniform MOFs. This generates colloidal-sized MOFs of defined polyhedral shape with tunable size in micrometer range that are suitable for in situ imaging. The 3D clusters formations are promoted by hydrophilic MOFs particles confined in aqueous droplets of binary water-lutidine mixture at transition temperature. Below this temperature, the water droplet decreases in volume due to one phase mixing with lutidine which forces the N-mers of faceted particles to aggregate in close contact. We compare the faceted clusters formed to those made of spherical particles in term of the building block sphericity. Other focus of our study involves the dynamic of the clusters. We found that, unlike spherical clusters, these faceted N-mers are highly stable on large scale of temperature due to their dominant capillary force on their facet-to-facet contact.

  14. Diagnosis, Management and Assessment of Adults with Joint Hypermobility Syndrome: A UK-Wide Survey of Physiotherapy Practice.

    PubMed

    Palmer, Shea; Cramp, Fiona; Lewis, Rachel; Muhammad, Shahid; Clark, Emma

    2015-06-01

    Joint hypermobility syndrome (JHS) is a heritable disorder associated with excessive joint range of motion and pain in the absence of inflammatory joint disease. It is a relatively common cause of musculoskeletal pain but is generally understood to be under-recognized and poorly managed in clinical practice. The present study therefore aimed to identify how JHS is diagnosed, managed and assessed in routine physiotherapy practice. A survey tool was developed from similar physiotherapy surveys of musculoskeletal practice, a review of the literature, and consultation with researchers and clinicians. Paper copies of the final survey were sent to 201 randomly selected secondary care organizations across the UK and an electronic version was advertised through physiotherapy professional networks. A total of 66 responses (80% women) were received from physiotherapists, with a wide range of clinical experience. Only 32% of respondents reported that they had received formal training in JHS management. The Brighton diagnostic criteria for JHS were not often used (only 31% of respondents). The stated aims of physiotherapy and the specific interventions employed seem well matched, with a focus on advice, education, exercise and self-management. Although pain relief was not reported as a high priority in terms of treatment aims, pain was most often assessed as an outcome, suggesting a mismatch between what clinicians aim to achieve and what they measure. The results suggest that reported management strategies are broadly appropriate to long-term musculoskeletal conditions but additional training specific to JHS may be required, particularly in diagnosis and assessment.

  15. Joint ventures in medical services.

    PubMed

    Rublee, D A

    1987-01-01

    This paper is an overview of joint-venture activity in healthcare, describing trends in joint ventures and raising issues for physicians. The purposes are to discuss the major current facets of joint-venture alliances in healthcare and to identify policy issues that arise from the trend to use joint ventures as an organizational tool. Speculation is made about the future role of joint ventures in the organization of healthcare.

  16. Shoulder function, pain and health related quality of life in adults with joint hypermobility syndrome/Ehlers-Danlos syndrome-hypermobility type.

    PubMed

    Johannessen, Elise Christine; Reiten, Helle Sundnes; Løvaas, Helene; Maeland, Silje; Juul-Kristensen, Birgit

    2016-07-01

    Purpose To investigate shoulder function, pain and Health-Related Quality of life (HRQoL) among adults with joint hypermobility syndrome/Ehlers-Danlos syndrome-hypermobility type (JHS/EDS-HT), compared with the general population (controls). Method In a cross-sectional study using postal survey, 110 patients diagnosed with JHS/EDS-HT and 140 gender- and age-matched healthy controls from Statistics Norway participated. Shoulder function, pain and HRQol were registered by Western Ontario Shoulder Instability Index (WOSI), Numerical Rating Scale (NRS), pain drawings, 36-item Short Form (SF-36). Results Eighty-one individuals responded, with response rate 34% (JHS/EDS-HT: 53%, controls: 21%). JHS/EDS-HT had lower shoulder function (WOSI total: 49.9 versus 83.3; p < 0.001), lower HRQol on SF-36 Physical Component Scale (PCS: 28.1 versus 49.9; p < 0.001), and higher pain intensity (NRS: 6.4 versus 2.7; p < 0.001) than controls. Neck and shoulder joints were rated as primary painful areas in both groups, with significantly higher frequency in JHS/EDS-HT (neck: 90% versus 27%; shoulder: 80% versus 37%). Further, JHS/EDS-HT most often reported generalized pain (96%). Conclusions Adults with JHS/EDS-HT have impaired shoulder function, increased pain intensity, as well as reduced physical HRQoL compared with controls. Although neck and shoulder were most frequently rated as painful, significantly more JHS/EDS-HT also reported generalized pain compared to controls. Implications for Rehabilitation Adults with JHS/EDS-HT have impaired shoulder function, and most often painful areas in the neck and shoulder joints, which need to be targeted in the treatment strategy. Compared with the general population adults with JHS/EDS-HT have reduced physical HRQoL, supporting a physical approach for this group. Adults with JHS/EDS-HT may present with both specific painful joints and generalized pain.

  17. Shoulder function, pain and health related quality of life in adults with joint hypermobility syndrome/Ehlers-Danlos syndrome-hypermobility type.

    PubMed

    Johannessen, Elise Christine; Reiten, Helle Sundnes; Løvaas, Helene; Maeland, Silje; Juul-Kristensen, Birgit

    2016-07-01

    Purpose To investigate shoulder function, pain and Health-Related Quality of life (HRQoL) among adults with joint hypermobility syndrome/Ehlers-Danlos syndrome-hypermobility type (JHS/EDS-HT), compared with the general population (controls). Method In a cross-sectional study using postal survey, 110 patients diagnosed with JHS/EDS-HT and 140 gender- and age-matched healthy controls from Statistics Norway participated. Shoulder function, pain and HRQol were registered by Western Ontario Shoulder Instability Index (WOSI), Numerical Rating Scale (NRS), pain drawings, 36-item Short Form (SF-36). Results Eighty-one individuals responded, with response rate 34% (JHS/EDS-HT: 53%, controls: 21%). JHS/EDS-HT had lower shoulder function (WOSI total: 49.9 versus 83.3; p < 0.001), lower HRQol on SF-36 Physical Component Scale (PCS: 28.1 versus 49.9; p < 0.001), and higher pain intensity (NRS: 6.4 versus 2.7; p < 0.001) than controls. Neck and shoulder joints were rated as primary painful areas in both groups, with significantly higher frequency in JHS/EDS-HT (neck: 90% versus 27%; shoulder: 80% versus 37%). Further, JHS/EDS-HT most often reported generalized pain (96%). Conclusions Adults with JHS/EDS-HT have impaired shoulder function, increased pain intensity, as well as reduced physical HRQoL compared with controls. Although neck and shoulder were most frequently rated as painful, significantly more JHS/EDS-HT also reported generalized pain compared to controls. Implications for Rehabilitation Adults with JHS/EDS-HT have impaired shoulder function, and most often painful areas in the neck and shoulder joints, which need to be targeted in the treatment strategy. Compared with the general population adults with JHS/EDS-HT have reduced physical HRQoL, supporting a physical approach for this group. Adults with JHS/EDS-HT may present with both specific painful joints and generalized pain. PMID:26824670

  18. A novel FGD1 mutation in a family with Aarskog–Scott syndrome and predominant features of congenital joint contractures

    PubMed Central

    Griffin, Laurie Beth; Farley, Frances A.; Antonellis, Anthony; Keegan, Catherine E.

    2016-01-01

    Mutations in FGD1 cause Aarskog–Scott syndrome (AAS), an X-linked condition characterized by abnormal facial, skeletal, and genital development due to abnormal embryonic morphogenesis and skeletal formation. Here we report a novel FGD1 mutation in a family with atypical features of AAS, specifically bilateral upper and lower limb congenital joint contractures and cardiac abnormalities. The male proband and his affected maternal uncle are hemizygous for the novel FGD1 mutation p.Arg921X. This variant is the most carboxy-terminal FGD1 mutation identified in a family with AAS and is predicted to truncate the FGD1 protein at the second to last amino acid of the carboxy-terminal pleckstrin homology (PH) domain. Our study emphasizes the importance of the 3′ peptide sequence in the structure and/or function of the FGD1 protein and further demonstrates the need to screen patients with X-linked congenital joint contractures for FGD1 mutations. PMID:27551683

  19. Multimodal Chiropractic Care of Pain and Disability for a Patient Diagnosed With Benign Joint Hypermobility Syndrome: A Case Report

    PubMed Central

    Strunk, Richard G.; Pfefer, Mark T.; Dube, Derrick

    2014-01-01

    Objective The purpose of this case report is to describe multimodal chiropractic care of a female patient diagnosed with benign joint hypermobility syndrome (BJHS) and a history of chronic spine pain. Clinical features A 23-year-old white female presented for chiropractic care with chronic low back pain, neck pain, and headaches. The patient was diagnosed with BJHS, including joint hypermobility of her thumbs, elbows, right knee, and lumbopelvic region. A 6-year history of low back pain and varicose veins in her posterior thighs and knees were additional significant diagnostic findings of BJHS. Interventions and outcomes The treatment consisted of spinal and extremity manipulation, Graston technique, and postisometric relaxation combined with sensory motor stimulation and scapular stabilization exercises. The patient was seen 15 times over an 18-week period. After 18 weeks of care, the Revised Oswestry Low Back Questionnaire and Headache Disability Index demonstrated clinically important improvements with her low back pain and headache; but little change was noted in her neck pain as measured by the Neck Disability Index. Conclusion This patient with BJHS who had decreased disability and spine pain improved after a course of multimodal chiropractic care. PMID:24711783

  20. Plasma Wakefield Experiments at FACET

    SciTech Connect

    Hogan, M.J.; England, R.J.; Frederico, J.; Hast, C.; Li, S.Z.; Litos, M.; Walz, D.; An, W.; Clayton, C.E.; Joshi, C.; Lu, W.; Marsh, K.A.; Mori, W.; Tochitsky, S.; Muggli, P.; Pinkerton, S.; Shi, Y.; /Southern California U.

    2011-08-19

    FACET, the Facility for Advanced Accelerator and Experimental Tests, is a new facility being constructed in sector 20 of the SLAC linac primarily to study beam driven plasma wakefield acceleration beginning in summer 2011. The nominal FACET parameters are 23GeV, 3nC electron bunches compressed to {approx}20{micro}m long and focused to {approx}10{micro}m wide. The intense fields of the FACET bunches will be used to field ionize neutral lithium or cesium vapor produced in a heat pipe oven. Previous experiments at the SLAC FFTB facility demonstrated 50GeV/m gradients in an 85cm field ionized lithium plasma where the interaction distance was limited by head erosion. Simulations indicate the lower ionization potential of cesium will decrease the rate of head erosion and increase single stage performance. The initial experimental program will compare the performance of lithium and cesium plasma sources with single and double bunches. Later experiments will investigate improved performance with a pre-ionized cesium plasma. The status of the experiments and expected performance are reviewed. The FACET Facility is being constructed in sector 20 of the SLAC linac primarily to study beam driven plasma wakefield acceleration. The facility will begin commissioning in summer 2011 and conduct an experimental program over the coming five years to study electron and positron beam driven plasma acceleration with strong wake loading in the non-linear regime. The FACET experiments aim to demonstrate high-gradient acceleration of electron and positron beams with high efficiency and negligible emittance growth.

  1. Anesthesia & Down Syndrome

    MedlinePlus

    ... occur in individuals with Down syndrome than their peers without Down syndrome. An awareness of these more ... of the eyes, ears, and joints - just like peers without Down syndrome. What About Down Syndrome Is ...

  2. Nosology and inheritance pattern(s) of joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type: a study of intrafamilial and interfamilial variability in 23 Italian pedigrees.

    PubMed

    Castori, Marco; Dordoni, Chiara; Valiante, Michele; Sperduti, Isabella; Ritelli, Marco; Morlino, Silvia; Chiarelli, Nicola; Celletti, Claudia; Venturini, Marina; Camerota, Filippo; Calzavara-Pinton, Piergiacomo; Grammatico, Paola; Colombi, Marina

    2014-12-01

    Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two markedly overlapping heritable connective tissue disorders. The cumulative frequency of JHS and EDS-HT seems high, but their recognition remains an exclusion diagnosis based on different sets of diagnostic criteria. Although proposed by a panel of experts, clinical identity between JHS and EDS-HT is still a matter of debate due to unknown molecular basis. We present 23 families with three or more individuals with a diagnosis of JHS and/or EDS-HT. Rough data from the 82 individuals were used to assess the frequency of major and minor criteria, as well as selected additional features. A series of statistical tools were applied to assess intrafamilial and interfamilial variability, emphasizing intergenerational, and intersex differences. This study demonstrates marked heterogeneity within and between families in terms of agreement of available diagnostic criteria. In 21 pedigrees affected individuals belong to two or three phenotypic sub-categories among JHS, EDS-HT, and JHS + EDS-HT overlap. Intergenerational analysis depicts a progressive shifting, also within the same pedigree, from EDS-HT in childhood, to JHS + EDS-HT in early adulthood and JHS later in life. Female-male ratio is 2.1:1, which results lower than previously observed in unselected patients' cohorts. In these pedigrees, JHS, EDS-HT, and JHS + EDS-HT segregate as a single dominant trait with complete penetrance, variable expressivity, and a markedly evolving phenotype. This study represents a formal demonstration that EDS-HT and JHS contitute the same clinical entity, and likely share the same genetic background, at least, in familial cases.

  3. Morphological Stability of Faceted Interfaces

    NASA Technical Reports Server (NTRS)

    Abbaschian, Reza; Golyshev, V. D.; Gonik, M.; Tsvetivsky, V.; deVahlDavis, G.; Leonardi, E.

    2001-01-01

    The major focus of this investigation is to study the fundamentals of layer spreading mechanisms during growth of doped Ge (a facet forming material), and to determine the conditions for morphological instability of vicinal solid-liquid interfaces. The investigation will also lead to the determination of the effect of dopants on the layer growth kinetics, step free energy, and dopant capture by the advancing ledges. The theoretical treatment of growth of faceted interfaces indicates that the kinetics of a step on a growing vicinal interface considerably depends on its angle of inclination, the melt concentration, and characteristics of flow currents in the melt. The morphological stability of the interface also depends on these parameters, as well as on the density and spreading velocity of the steps. However, the treatment of the instability of the interface by the layer growth mechanism is rather difficult because it requires exact knowledge of the thermal and solutal fields, hydrodynamics of the melt, and supercooling at the interface. The results of recent space experiments of the principal investigator involving directional solidification of faceted Bi-Sn alloys have shown that the morphological stability of various crystallographic orientations is significantly affected by the anistropy in interfacial properties of the faceted alloy in general, and the interface kinetics in particular. These findings have also raised many important and fundamental questions, particularly with respect to the behavior of interfacial steps, which need to be addressed via additional groundbased and microgravity experiments. For the present investigation we will use a novel crystal growth technique which provides axial heat flux close to the solid-liquid boundary. The Axial Heat Processing (AHP) technique allows for precise control and determination of the heat and mass transfer close to the crystallization front, and the establishment of a planar interface over the entire cross

  4. Design of a lattice-based faceted classification system

    NASA Technical Reports Server (NTRS)

    Eichmann, David A.; Atkins, John

    1992-01-01

    We describe a software reuse architecture supporting component retrieval by facet classes. The facets are organized into a lattice of facet sets and facet n-tuples. The query mechanism supports precise retrieval and flexible browsing.

  5. Novel X-linked syndrome of cardiac valvulopathy, keloid scarring, and reduced joint mobility due to filamin A substitution G1576R.

    PubMed

    Atwal, Paldeep Singh; Blease, Sophie; Braxton, Alicia; Graves, Julia; He, Weimin; Person, Richard; Slattery, Leah; Bernstein, Jonathan Adam; Hudgins, Louanne

    2016-04-01

    Filamin A (FLNA) is known to be involved in intracellular actin binding, cell migration, scaffolding, and signaling. We report a novel X-linked syndrome characterized by cardiac valvular disease, keloid scarring and reduced joint mobility in male second cousins due to a previously unreported mutation in FLNA. Whole exome sequencing was performed using standard methods and segregation analysis was performed in affected and non-affected family members. A novel hemizygous c.4726G>A (p.G1576R) mutation in FLNA was detected. Segregation analysis performed on multiple maternal family members showed c.4726G>A (p.G1576R) segregated with disease in an X-linked inheritance pattern. The findings in these cases are distinct from previously described FLNA related disorders by virtue of decreased joint mobility and spontaneous keloid scarring. They occur in association with a novel mutation and represent a novel genetic syndrome.

  6. [The role of computed tomography and magnetic resonance in assessing degenerative arthropathy of the lumbar articular facets].

    PubMed

    Leone, A; Aulisa, L; Tamburrelli, F; Lupparelli, S; Tartaglione, T

    1994-11-01

    Degenerative arthropathy of the lumbar facet joints remains a debated issue relative to both its etiopathogenesis and its clinical significance. The authors studied 9 autoptic specimens by means of CT and MRI: the diagnostic value of the two methods was assessed taking the histopathologic findings of the relative specimens as the gold standard. The following signs of degenerative arthropathy were investigated in each specimen: cartilaginous wears, hypertrophy of the articular processes, osteophytosis, subchondral sclerosis and geodes and capsular and ligamentous calcifications. CT clearly demonstrated the characteristic signs of arthropathy, although failing to assess the cartilaginous wears in the early degeneration phases. Cartilaginous surface tears were directly depicted by MRI in the specimens showing medium and advanced degeneration. In our opinion, CT represents the examination of choice in the diagnosis of degenerative arthropathy of the lumbar apophyseal joints. Nevertheless, human trials are needed to assess MR capabilities in better detailing subchondral bone structure and in depicting the joint capsule and the synovial membrane and fluid as a major MR potential to diagnose back pain syndromes arising from the posterior arch.

  7. Sandwich construction solar structural facets

    SciTech Connect

    Diver, R.B.; Grossman, J.W.

    1999-07-01

    Silver/glass mirrors have excellent optical properties but need a method of support in order to be used in concentrating solar thermal systems. In collaboration with the Cummins dish/Stirling development program, the authors started investigating sandwich construction as a way to integrate silver/glass mirrors into solar optical elements. In sandwich construction, membranes such as sheet metal or plastic are bonded to the front and back of a core (like a sandwich). For solar optical elements, a glass mirror is bonded to one of the membranes. This type of construction has the advantages of a high strength-to-weight ratio, and reasonable material and manufacturing cost. The inherent stiffness of sandwich construction mirror panels also facilitates large panels. This can have cost advantages for both the amount of hardware required as well as reduced installation and alignment costs. In addition, by incorporating the panels into the support structure reductions in the amount of structural support required are potentially possible. The authors have investigated sandwich construction panels that employ cores of polystyrene, polyvinyl chloride (PVC) and polyurethane foams as well as conventional aluminum and cardboard honeycombs. The authors investigations have involved fabricating 0.5 x 0.6-m (20 x 24-inch) spherical-contour panels and testing their optical properties and environmental durability. The authors have also performed preliminary cost and performance studies. Evaluations included optical testing with the SunLab 2f and VSHOT tools both before and after exposures to environmental chamber testing. The results showed that sandwich mirror panels are potentially very accurate. However, long-term degradation due to creep was evident in all of the foam core facets. The aluminum honeycomb core facets were accurate and durable. In this paper, the design principles that guided the investigations, estimates of cost, and the results of the experimental investigations are

  8. Amazing growth of helium crystal facets

    NASA Astrophysics Data System (ADS)

    Tsymbalenko, V. L.

    2015-11-01

    This review systematizes experimental data from the study of two unusual phenomena: the superslow growth of a perfect, growth-defect-free crystal facet, and the abrupt transition of a crystal facet to an anomalous state with a growth rate greater by two to three orders of magnitude than the normal value (the 'burstlike growth effect').

  9. Late diagnosis of lateral meningocele syndrome in a 55-year-old woman with symptoms of joint instability and chronic musculoskeletal pain.

    PubMed

    Castori, Marco; Morlino, Silvia; Ritelli, Marco; Brancati, Francesco; De Bernardo, Carmelilia; Colombi, Marina; Grammatico, Paola

    2014-02-01

    Lateral meningocele syndrome (LMS) is a rare hereditary connective tissue disorder characterized by pan-spinal meningoceles, specific facial dysmorphism, skeletal and soft tissue abnormalities, and hypotonia and/or muscle weakness. LMS has been observed in eleven patients with two instances of vertical transmission, and seven sporadic cases with an age at diagnosis ranging from 25 months to 33 years. We report on a further observation of LMS in a 55-year-old woman presenting with a long history of joint instability, chronic musculoskeletal pain, and iatrogenic bladder and anorectal dysfunction due to irreversible nerve damage after surgical excision of a meningeal cyst. Her clinical characteristics are compared with those of previously reported patients, as well as two further cases originally diagnosed with Hajdu-Cheney and Ehlers-Danlos syndromes, but displaying typical features of LMS. PMID:24311540

  10. Frey's Syndrome Consequent to an Unusual Pattern of Temporomandibular Joint Dislocation: Case Report with Review of Its Incidence and Etiology

    PubMed Central

    Kamath, Rajay A. D.; Bharani, Shiva; Prabhakar, Suhas

    2013-01-01

    Frey's syndrome was first described in the 18th century. Recognizing it as a nonspecific condition, the symptom of gustatory sweating in patients with parotid gland inflammation was described by Duphenix and Baillarger. However, as a specific diagnostic entity, gustatory sweating, following trauma to parotid glands, was first described by Polish neurologist Lucie Frey, in 1923, and hence he proposed the term auriculotemporal syndrome. The condition is characterized by sweating, flushing, a sense of warmth, and occasional pain in the preauricular and temporal areas, following the production of a strong salivary stimulus. Several etiologies of Frey's syndrome have been mentioned in the literature; however, none attribute dislocation of the “intact” mandibular condyle as a cause of the syndrome. Reviewing its pathophysiology, etiology, and incidence in detail, we describe a case of Frey's syndrome subsequent to superolateral dislocation of the intact mandibular condyle following fracture of the anterior mandible. Its management and prevention are also discussed in brief. PMID:24436729

  11. Method for partially coating laser diode facets

    NASA Technical Reports Server (NTRS)

    Dholakia, Anil R. (Inventor)

    1990-01-01

    Bars of integral laser diode devices cleaved from a wafer are placed with their p regions abutting and n regions abutting. A thin BeCu mask having alternate openings and strips of the same width as the end facets is used to mask the n region interfaces so that multiple bars can be partially coated over their exposed p regions with a reflective or partial reflective coating. The partial coating permits identification of the emitting facet from the fully coated back facet during a later device mounting procedure.

  12. Facet development for a faceted stretched-membrane dish by SAIC

    SciTech Connect

    Not Available

    1991-10-01

    The concept for a multi-facet stretched-membrane dish concentrator could reduce the cost and weight of solar thermal dish systems. A stretched-membrane mirror facet for such a multi-facet solar dish concentrator has been developed by Science Applications International Corporation (SAIC). Twelve of the 3.7-m diameter facets will be used to form a 115-m{sup 2} dish concentrator, providing 75 kW{sub th} to operate a 25-kW{sub e} Stirling engine for electric power production. The facet SAIC designed is focused using a vacuum system to elastically deform the thin (0.003-inch thick) stainless steel facet membranes. Elastic focusing was chosen over plastically deforming the membrane to a parabolic shape because it results in a simple manufacturing process. The SAIC facet can be focused from infinity to a minimum focal length-to-diameter ratio of about 2.7. Analytical design studies and experimental tests were performed to evaluate stresses in the ring and membranes during operation, the effects of strain cycling on the reflective surface, and to measure the optical quality of the mirror facets. SAIC produced two prototype mirror facets and they were optically tested at the Solar Energy Research Institute and at Sandia National Laboratories. The first facet showed slope errors ranging from 2.95 to 3.3 mrad over the f/d range of 2.7 to 3.0.

  13. Testing of the prototype facets for the stretched-membrane faceted dish

    SciTech Connect

    Grossman, J.W.; Houser, R.M.; Erdman, W.W.

    1991-12-01

    The Faceted Stretched-Membrane Dish Program is part of a DOE-sponsored effort to develop a commercial 25 kWe dish/Stirling system employing a twelve-facet dish concentrator. The facets will utilize the stretched-membrane technology originated in the heliostat development program. Each facet is constructed with a thin metal membrane stretched over both sides of a steel ring. When a small vacuum is induced between the membranes they assume a parabolic contour capable of concentrating sunlight at a predetermined focal length. A reflective polymer film is attached to the face of the facet of the facet to enhance the optical performance. During Phase II of the Faceted Stretched-Membrane Dish Program, Science Applications International Corp. and Solar Kinetics, Inc., constructed prototype 3.5-meter facets utilizing different design approaches to demonstrate their manufacturability and optical performance. Sandia engaged in a program to determine the on-sun performance of the facets (for f/Ds of 2.7 to 3.0). A uniformly distributed slope error was used as the basis for comparison. Flux arrays based on slope error from a computer model were compared to a measured flux array for each facet. The slope error for the facet was determined by the value that would produce a modeled array with the minimum mean square difference to the measured array. The facet produced by SAIC demonstrated uniform slope errors of 2.2 to 3.0 milliradians with peak flux intesities of 334 to 416 kW/m{sup 2}. The SKI facet had slope errors of 1.6 to 1.9 milliradians with peak flux intesities of 543 to 1186 kW/m{sup 2}.

  14. Unusual cause of neck pain: septic arthritis of a cervical facet.

    PubMed

    Jones, Jaime L; Ernst, Amy A

    2012-11-01

    Neck pain is a common cause for presentation to an emergency department. Most causes are benign and often secondary to arthritis or injuries. We present a case of septic cervical facet arthritis, a very rare cause of neck pain. The clinical presentation of septic cervical facet arthritis includes fever, neck pain that is often unilateral that is worse with movement, nerve root symptoms, and radiation of pain to the shoulder. Consequences may be severe and include joint destruction and infection progression. Symptoms may be indolent, and a high index of suspicion is necessary to make this diagnosis.

  15. FACET: SLAC___s New User Facility

    SciTech Connect

    Clarke, C.I.; Decker, F.-J.; England, R.J.; Erickson, R.A.; Hast, C.; Hogan, M.J.; Li, S.Z.; Litos, M.D.; Nosochkov, Y.; Seeman, J.T.; Sheppard, J.; Wienands, U.; Woodley, M.; Yocky, G.; /SLAC

    2012-05-16

    FACET (Facility for Advanced Accelerator Experimental Tests) is a new User Facility at SLAC National Accelerator Laboratory. The first User Run started in spring 2012 with 20 GeV, 3 nC electron beams. The facility is designed to provide short (20 {micro}m) bunches and small (20 {micro}m wide) spot sizes, producing uniquely high power beams. FACET supports studies from many fields but in particular those of Plasma Wakefield Acceleration and Dielectric Wakefield Acceleration. The creation of drive and witness bunches and shaped bunch profiles is possible with 'Notch' Collimation. FACET is also a source of THz radiation for material studies. Positrons will be available at FACET in future user runs. We present the User Facility and the available tools and opportunities for future experiments.

  16. Stability of crystal facets in gold nanorods.

    PubMed

    Katz-Boon, Hadas; Walsh, Michael; Dwyer, Christian; Mulvaney, Paul; Funston, Alison M; Etheridge, Joanne

    2015-03-11

    Metal nanocrystals can be grown in a variety of shapes through the modification of surface facet energies via surfactants. However, the surface facets are only a few atoms wide, making it extremely challenging to measure their geometries and energies. Here, we locate and count atoms in Au nanorods at successive time intervals using quantitative scanning transmission electron microscopy. This enables us to determine the atomic-level geometry and the relative stability of the facets and to expound their relationship to the overall three-dimensional nanocrystal shape and size. We reveal coexisting high- and low-index facets with comparable stability and dimensions and find the geometry of the nanorods is remarkably stable, despite significant atom movements. This information provides unique insights into the mechanisms that govern growth kinetics and nanocrystal morphology. PMID:25658226

  17. FACET: Future ATM Concepts Evaluation Tool

    NASA Technical Reports Server (NTRS)

    Bilmoria, Karl D.; Banavar, Sridhar; Chatterji, Gano B.; Sheth, Kapil S.; Grabbe, Shon

    2000-01-01

    FACET (Future ATM Concepts Evaluation Tool) is an Air Traffic Management research tool being developed at the NASA Ames Research Center. This paper describes the design, architecture and functionalities of FACET. The purpose of FACET is to provide E simulation environment for exploration, development and evaluation of advanced ATM concepts. Examples of these concepts include new ATM paradigms such as Distributed Air-Ground Traffic Management, airspace redesign and new Decision Support Tools (DSTs) for controllers working within the operational procedures of the existing air traffic control system. FACET is currently capable of modeling system-wide en route airspace operations over the contiguous United States. Airspace models (e.g., Center/sector boundaries, airways, locations of navigation aids and airports) are available from databases. A core capability of FACET is the modeling of aircraft trajectories. Using round-earth kinematic equations, aircraft can be flown along flight plan routes or great circle routes as they climb, cruise and descend according to their individual aircraft-type performance models. Performance parameters (e.g., climb/descent rates and speeds, cruise speeds) are obtained from data table lookups. Heading, airspeed and altitude-rate dynamics are also modeled. Additional functionalities will be added as necessary for specific applications. FACET software is written in Java and C programming languages. It is platform-independent, and can be run on a variety of computers. FACET has been designed with a modular software architecture to enable rapid integration of research prototype implementations of new ATM concepts. There are several advanced ATM concepts that are currently being implemented in FACET airborne separation assurance, dynamic density predictions, airspace redesign (re-sectorization), benefits of a controller DST for direct-routing, and the integration of commercial space transportation system operations into the U.S. National

  18. Labyrinth-induced faceted electrochemical growth.

    PubMed

    Scherer, Maik R J; Cunha, Pedro M S; Steiner, Ullrich

    2014-04-16

    A path-length bias of nucleated electrochemical growth in a 3D periodic nano-maze is found to cause facet formation of an intrinsically isotropic material in a porous self-assembled gyroid network. This is the first report of faceted electrochemical growth that is not based on the crystallographic order of the constituent building blocks, but rather reflects the symmetry of the template in which the material is synthesized.

  19. Percutaneous neurotomy of the ramus medialis in case of a chronical lumbar zygapophysial joint syndrome by laser application

    NASA Astrophysics Data System (ADS)

    Stern, St.

    2000-06-01

    The present prospective study aims at determining whether denervation of the zygapophysial joints can be rendered safer and more efficiently by combining modern imaging procedures with the laser technique.

  20. MultiFacet: A Faceted Interface for Browsing Large Multimedia Collections

    SciTech Connect

    Henry, Michael J.; Hampton, Shawn D.; Endert, Alexander; Roberts, Ian E.; Payne, Deborah A.

    2013-10-31

    Faceted browsing is a common technique for exploring collections where the data can be grouped into a number of pre-defined categories, most often generated from textual metadata. Historically, faceted browsing has been applied to a single data type such as text or image data. However, typical collections contain multiple data types, such as information from web pages that contain text, images, and video. Additionally, when browsing a collection of images and video, facets are often created based on the metadata which may be incomplete, inaccurate, or missing altogether instead of the actual visual content contained within those images and video. In this work we address these limitations by presenting MultiFacet, a faceted browsing interface that supports multiple data types. MultiFacet constructs facets for images and video in a collection from the visual content using computer vision techniques. These visual facets can then be browsed in conjunction with text facets within a single interface to reveal relationships and phenomena within multimedia collections. Additionally, we present a use case based on real-world data, demonstrating the utility of this approach towards browsing a large multimedia data collection.

  1. Turner's syndrome.

    PubMed

    Ranke, M B; Saenger, P

    2001-07-28

    Before chromosomal analysis became available, the diagnosis of Turner's syndrome was based on the characteristics independently described by Otto Ullrich and Henry Turner, such as short stature, gonadal dysgenesis, typical, visible dysmorphic stigmata, and abnormalities in organs, which present in individuals with a female phenotype. Today, Turner's syndrome or Ullrich-Turner's syndrome may be defined as the combination of characteristic physical features and complete or part absence of one of the X chromosomes, frequently accompanied by cell-line mosaicism. The increasing interest in Turner's syndrome over the past two decades has been motivated both by the quest for a model by which the multi-faceted features of this disorder can be understood, and the endeavour to provide life-long support to the patient. New developments in research allow patients with Turner's syndrome to have multidisciplinary care.

  2. 'Costen's syndrome'--correlation or coincidence: a review of 45 patients with temporomandibular joint dysfunction, otalgia and other aural symptoms.

    PubMed

    Brookes, G B; Maw, A R; Coleman, M J

    1980-02-01

    Forty-five patients with temporomandibular joint dysfunction, and otalgia together with other aural symptoms (deafness, tinnitus, pressure/blockage and vertigo) were evaluated clinically and audiometrically. The theoretical mechanisms by which aural symptoms may be produced as a result of temporomandibular joint dysfunction are outlined and discussed in the light of the patients under review. The wide diversity in the incidence of additional aural symptoms apart from otalgia reported in the literature is noted, together with the general lack of full objective audiometric assessment. In 37 patients the aural symptoms were directly attributable to other coincidental otolaryngological pathology. Details of the remaining 8 cases are presented. The other aural symptoms of 4 of these patients were also probably accounted for by other coincidental otalaryngological pathology. It may be significant that 2 of the other patients were suffering from concurrent psychiatric disorders. Thus in this series at least 9% of the patients were considered to have other aural symptoms coincidental to temporomandibular joint dysfunction. This is compatible with the relatively common occurrence of both temporomandibular joint dysfunction and aural symptoms in the general population. This study leads us to believe that there is no direct aetiological basis to link temporomandibular joint dysfunction and other aural symptoms apart from otalgia. PMID:7363490

  3. Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents.

    PubMed

    Kras, Jeffrey V; Weisshaar, Christine L; Pall, Parul S; Winkelstein, Beth A

    2015-09-14

    Non-physiological stretch of the cervical facet joint's capsular ligament induces persistent behavioral hypersensitivity and spinal neuronal hyperexcitability via an intra-articular NGF-dependent mechanism. Although that ligament is innervated by nociceptors, it is unknown if a subpopulation is exclusively responsible for the behavioral and spinal neuronal responses to intra-articular NGF and/or facet joint injury. This study ablated joint afferents using the neurotoxin saporin targeted to neurons involved in either peptidergic ([Sar(9),Met (O2)(11)]-substance P-saporin (SSP-Sap)) or non-peptidergic (isolectin B4-saporin (IB4-Sap)) signaling to investigate the contributions of those neuronal populations to facet-mediated pain. SSP-Sap, but not IB4-Sap, injected into the bilateral C6/C7 facet joints 14 days prior to an intra- articular NGF injection prevents NGF-induced mechanical and thermal hypersensitivity in the forepaws. Similarly, only SSP- Sap prevents the increase in mechanical forepaw stimulation- induced firing of spinal neurons after intra-articular NGF. In addition, intra-articular SSP-Sap prevents both behavioral hypersensitivity and upregulation of NGF in the dorsal root ganglion after a facet joint distraction that normally induces pain. These findings collectively suggest that disruption of peptidergic signaling within the joint may be a potential treatment for facet pain, as well as other painful joint conditions associated with elevated NGF, such as osteoarthritis.

  4. Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration

    PubMed Central

    Nakamura, Akihiro; Sharma, Anirudh; Lewis, Stephen J.; Wu, Brian; Datta, Poulami; Sundararajan, Kala; Endisha, Helal; Rossomacha, Evgeny; Rockel, Jason S.; Jurisica, Igor

    2016-01-01

    Osteoarthritis (OA) of spine (facet joints [FJs]) is one of the major causes of severe low back pain and disability worldwide. The degeneration of facet cartilage is a hallmark of FJ OA. However, endogenous mechanisms that initiate degeneration of facet cartilage are unknown, and there are no disease-modifying therapies to stop FJ OA. In this study, we have identified microRNAs (small noncoding RNAs) as mediators of FJ cartilage degeneration. We first established a cohort of patients with varying degrees of facet cartilage degeneration (control group: normal or mild facet cartilage degeneration; FJ OA group: moderate to severe facet cartilage degeneration) and then screened 2,100 miRNAs and identified 2 miRNAs (miR-181a-5p and miR-4454) that were significantly elevated in FJ OA cartilage compared with control facet cartilage. We further explored their role, function, and signaling mechanisms using computational, in vitro functional, and in vivo studies. We specifically indicate that miR-181a-5p and miR-4454 are involved in promoting inflammatory, catabolic, and cell death activity in FJ chondrocytes. This is the first report to our knowledge that identifies miR-181a-5p and miR-4454 as mediators of cartilage degeneration in FJs and potential therapeutic targets for stopping cartilage degeneration. PMID:27699225

  5. Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration

    PubMed Central

    Nakamura, Akihiro; Sharma, Anirudh; Lewis, Stephen J.; Wu, Brian; Datta, Poulami; Sundararajan, Kala; Endisha, Helal; Rossomacha, Evgeny; Rockel, Jason S.; Jurisica, Igor

    2016-01-01

    Osteoarthritis (OA) of spine (facet joints [FJs]) is one of the major causes of severe low back pain and disability worldwide. The degeneration of facet cartilage is a hallmark of FJ OA. However, endogenous mechanisms that initiate degeneration of facet cartilage are unknown, and there are no disease-modifying therapies to stop FJ OA. In this study, we have identified microRNAs (small noncoding RNAs) as mediators of FJ cartilage degeneration. We first established a cohort of patients with varying degrees of facet cartilage degeneration (control group: normal or mild facet cartilage degeneration; FJ OA group: moderate to severe facet cartilage degeneration) and then screened 2,100 miRNAs and identified 2 miRNAs (miR-181a-5p and miR-4454) that were significantly elevated in FJ OA cartilage compared with control facet cartilage. We further explored their role, function, and signaling mechanisms using computational, in vitro functional, and in vivo studies. We specifically indicate that miR-181a-5p and miR-4454 are involved in promoting inflammatory, catabolic, and cell death activity in FJ chondrocytes. This is the first report to our knowledge that identifies miR-181a-5p and miR-4454 as mediators of cartilage degeneration in FJs and potential therapeutic targets for stopping cartilage degeneration.

  6. A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene.

    PubMed

    Girisha, Katta Mohan; Kortüm, Fanny; Shah, Hitesh; Alawi, Malik; Dalal, Ashwin; Bhavani, Gandham SriLakshmi; Kutsche, Kerstin

    2016-08-01

    We report two brothers from a consanguineous couple with spondyloepimetaphyseal dysplasia (SEMD), multiple joint dislocations at birth, severe joint laxity, scoliosis, gracile metacarpals and metatarsals, delayed bone age and poorly ossified carpal and tarsal bones, probably representing a yet uncharacterized SEMD with laxity and dislocations. This condition has clinical overlap with autosomal dominantly inherited SEMD with joint laxity, leptodactylic type caused by recurrent missense variants in the kinesin family member 22 gene (KIF22). Single-nucleotide polymorphism array analysis and whole-exome sequencing in the two affected siblings revealed a shared homozygous nonsense variant [c.906T>A/p.(Tyr302*)] in EXOC6B as the most likely cause. EXOC6B encodes a component of the exocyst complex required for tethering secretory vesicles to the plasma membrane. As transport of vesicles from the golgi apparatus to the plasma membrane occurs through kinesin motor proteins along microtubule tracks, the function of EXOC6B is linked to KIF22 suggesting a common pathogenic mechanism in skeletal dysplasias with joint laxity and dislocations. PMID:26669664

  7. Facet development for a faceted stretched-membrane dish by Solar Kinetics, Inc

    SciTech Connect

    Schertz, P.T.; Brown, D.C.; Konnerth, A. III )

    1991-07-01

    A 3.6-meter diameter stretched-membrane optical facet for a parabolic dish has been successfully designed and demonstrated under contract with Sandia National Laboratories. Twelve facets identical to them will be used to make the lightweight reflector of the dish. The project goal of 2.5-mrad surface accuracy was met with each of the two full-sized prototypes, and accuracies of as low as 1.1 mrad were achieved. The facet weight is 11.7 kg/m{sup 2} (2.4lbs/ft{sup 2}). The facet is similar in construction to the successful stretched-membrane heliostat; it has two thin metal membranes attached to a ring. However, the front membrane for this facet is plastically formed at the factor in order to achieve a shorter facet f/D (approximately 3.0). A passive tether restrains the from membrane when not in operation, that is, when the stabilizing vacuum is off. The optical surface is achieved with a silvered-acrylic film laminated to the metal membrane. The facet is expected to cost $55.40/m{sup 2} at a production rate of 10,000 facets per year and $115, 000/m{sup 2}-at a production rate of 500 facets a year. Several key issues have been resolved. Stress concentrations due to seams in the reflective laminate did not cause membrane rupture during forming as they have for dishes with lower focal length-to-diameter ratios. The laminate survived the forming process and simulated operation without deterioration. The optical effect of the tether on the membrane was tested and found to be very small. Most important, highly accurate shapes were obtained using a simple forming procedure. Additional tests are needed to demonstrate process repeatablility and facet performance in typical operating conditions. 18 refs., 36 figs., 11 tabs.

  8. Laser ionized preformed plasma at FACET

    NASA Astrophysics Data System (ADS)

    Green, S. Z.; Adli, E.; Clarke, C. I.; Corde, S.; Edstrom, S. A.; Fisher, A. S.; Frederico, J.; Frisch, J. C.; Gessner, S.; Gilevich, S.; Hering, P.; Hogan, M. J.; Jobe, R. K.; Litos, M.; May, J. E.; Walz, D. R.; Yakimenko, V.; Clayton, C. E.; Joshi, C.; Marsh, K. A.; Vafaei-Najafabadi, N.; Muggli, P.

    2014-08-01

    The Facility for Advanced Accelerator and Experimental Tests (FACET) at SLAC installed a 10-TW Ti : sapphire laser system for pre-ionized plasma wakefield acceleration experiments. High energy (500 mJ), short (50 fs) pulses of 800 nm laser light at 1 Hz are used at the FACET experimental area to produce a plasma column. The laser pulses are stretched to 250 fs before injection into a vapor cell, where the laser is focused by an axicon lens to form a plasma column that can be sustained over the desired radius and length. A 20 GeV electron bunch interacts with this preformed plasma to generate a non-linear wakefield, thus accelerating a trailing witness bunch with gradients on the order of several GV m-1. The experimental setup and the methods for producing the pre-ionized plasma for plasma wakefield acceleration experiments performed at FACET are described.

  9. Facet engineering of high power single emitters

    NASA Astrophysics Data System (ADS)

    Yanson, Dan; Levi, Moshe; Shamay, Moshe; Tesler, Renana; Rappaport, Noam; Don, Yaroslav; Karni, Yoram; Schnitzer, Itzhak; Sicron, Noam; Shusterman, Sergey

    2011-03-01

    The ever increasing demand for high-power, high-reliability operation of single emitters at 9xx nm wavelengths requires the development of laser diodes with improved facet regions immune to both catastrophic and wear-out failure modes. In our study, we have evaluated several laser facet definition technologies in application to 90 micron aperture single emitters in asymmetric design (In)GaAs/AlGaAs based material emitting at 915, 925 and 980nm. A common epitaxy and emitter design makes for a straightforward comparison of the facet technologies investigated. Our study corroborates a clear trend of increasing difficulty in obtaining reliable laser operation from 980nm down to 915nm. At 980nm, one can employ dielectric facet passivation with a pre-clean cycle delivering a device lifetime in excess of 3,000 hours at increasing current steps. At 925nm, quantum-well intermixing can be used to define non-absorbing mirrors giving good device reliability, albeit with a large efficiency penalty. Vacuum cleaved emitters have delivered excellent reliability at 915nm, and can be expected to perform just as well at 925 and 980nm. Epitaxial regrowth of laser facets is under development and has yet to demonstrate an appreciable reliability improvement. Only a weak correlation between start-of-life catastrophic optical mirror damage (COMD) levels and reliability was established. The optimized facet design has delivered maximum powers in excess of 19 MW/sq.cm (rollover limited) and product-grade 980nm single emitters with a slope efficiency of >1 W/A and a peak efficiency of >60%. The devices have accumulated over 1,500 hours of CW operation at 11W. A fiber-coupled device emits 10W ex-fiber with 47% efficiency.

  10. Joint attention of six-month-old Down syndrome and preterm infants: I. Attention to toys and mother.

    PubMed

    Landry, S H; Chapieski, M L

    1990-03-01

    Six-month-old infants with Down syndrome (n = 14) and mental and motor-age-matched high-risk preterm infants (n = 15) were studied with respect to their use of separate attentional processes under conditions with and without their mother's direct involvement in play. As predicted, compared to preterm infants, the infants with Down syndrome spent less time involved with toys and more time looking at their mothers whether or not their mothers were actively involved. Although both infant groups showed an increase in the amount of time spent attending to toys in the mother-involved condition compared to the independent condition, only the preterm infants examined a wider range of toys when interacting with their mothers. Also, the infants with Down syndrome showed fewer shifts of attention to a toy in response to their mother's attempts to redirect their attention and, unlike the preterm infants, did not show increased positive affect when interacting with their mothers compared to playing on their own. PMID:2138464

  11. Alignment and focus of mirrored facets of a heliosat

    DOEpatents

    Yellowhair, Julius E; Ho, Clifford Kuofei; Diver, Richard B; Moss, Timothy A

    2013-11-12

    Various technologies pertaining to aligning and focusing mirrored facets of a heliostat are described herein. Updating alignment and/or focus of mirrored facets is undertaken through generation of a theoretical image, wherein the theoretical image is indicative of a reflection of the target via the mirrored facets when the mirrored facets are properly aligned. This theoretical image includes reference points that are overlaid on an image of the target as reflected by the mirrored facets of the heliostat. A technician adjusts alignment/focus of a mirrored facet by causing reflected reference markings to become aligned with the reference points in the theoretical image.

  12. Joint swelling

    MedlinePlus

    Swelling of a joint ... Joint swelling may occur along with joint pain . The swelling may cause the joint to appear larger or abnormally shaped. Joint swelling can cause pain or stiffness. After an ...

  13. Problem of time: facets and Machian strategy.

    PubMed

    Anderson, Edward

    2014-10-01

    The problem of time is that "time" in each of ordinary quantum theory and general relativity are mutually incompatible notions. This causes difficulties in trying to put these two theories together to form a theory of quantum gravity. The problem of time has eight facets in canonical approaches. I clarify that all but one of these facets already occur at the classical level, and reconceptualize and re-name some of these facets as follows. The frozen formalism problem becomes temporal relationalism, the thin sandwich problem becomes configurational relationalism, via the notion of best matching. The problem of observables becomes the problem of beables, and the functional evolution problem becomes the constraint closure problem. I also outline how each of the global and multiple-choice problems of time have their own plurality of facets. This article additionally contains a local resolution to the problem of time at the conceptual level and which is actually realizable for the relational triangle and minisuperspace models. This resolution is, moreover, Machian, and has three levels: classical, semiclassical, and a combined semiclassical-histories-timeless records scheme. I end by delineating the current frontiers of this program toward resolution of the problem of time in the cases of full general relativity and of slightly inhomogeneous cosmology.

  14. Perovskite solar cells: Different facets of performance

    NASA Astrophysics Data System (ADS)

    Eperon, Giles E.; Ginger, David S.

    2016-08-01

    The electronic properties of halide perovskites vary significantly between crystalline grains, but the impact of this heterogeneity on solar cell performance is unclear. Now, this variability is shown to limit the photovoltaic properties of solar cells, and its origins are linked to differing properties between crystal facets.

  15. Problem of time: facets and Machian strategy.

    PubMed

    Anderson, Edward

    2014-10-01

    The problem of time is that "time" in each of ordinary quantum theory and general relativity are mutually incompatible notions. This causes difficulties in trying to put these two theories together to form a theory of quantum gravity. The problem of time has eight facets in canonical approaches. I clarify that all but one of these facets already occur at the classical level, and reconceptualize and re-name some of these facets as follows. The frozen formalism problem becomes temporal relationalism, the thin sandwich problem becomes configurational relationalism, via the notion of best matching. The problem of observables becomes the problem of beables, and the functional evolution problem becomes the constraint closure problem. I also outline how each of the global and multiple-choice problems of time have their own plurality of facets. This article additionally contains a local resolution to the problem of time at the conceptual level and which is actually realizable for the relational triangle and minisuperspace models. This resolution is, moreover, Machian, and has three levels: classical, semiclassical, and a combined semiclassical-histories-timeless records scheme. I end by delineating the current frontiers of this program toward resolution of the problem of time in the cases of full general relativity and of slightly inhomogeneous cosmology. PMID:25266113

  16. Synthesis of {100} facet dominant anatase TiO2 nanobelts and the origin of facet-dependent photoreactivity.

    PubMed

    Pan, Feng; Wu, Kai; Li, Hexing; Xu, Guoqin; Chen, Wei

    2014-11-10

    Sword-like anatase TiO2 nanobelts exposed with 78% clean {100} facets were synthesized and the facet-dependent photoreactivity of anatase TiO2 was investigated. By quantitative comparison with the reference {001} facets, the {100} facets possessed about ten-times higher active sites density than that on {001} facets, resulting in higher photoreaction efficiency. After the active sites density normalization, the {100} and {001} facets exhibited distinct wavelength-dependent photocatalytic performance, attributed to the anisotropic electronic structures in TiO2 crystals. PMID:25255881

  17. Facet-Selective Epitaxy of Compound Semiconductors on Faceted Silicon Nanowires.

    PubMed

    Mankin, Max N; Day, Robert W; Gao, Ruixuan; No, You-Shin; Kim, Sun-Kyung; McClelland, Arthur A; Bell, David C; Park, Hong-Gyu; Lieber, Charles M

    2015-07-01

    Integration of compound semiconductors with silicon (Si) has been a long-standing goal for the semiconductor industry, as direct band gap compound semiconductors offer, for example, attractive photonic properties not possible with Si devices. However, mismatches in lattice constant, thermal expansion coefficient, and polarity between Si and compound semiconductors render growth of epitaxial heterostructures challenging. Nanowires (NWs) are a promising platform for the integration of Si and compound semiconductors since their limited surface area can alleviate such material mismatch issues. Here, we demonstrate facet-selective growth of cadmium sulfide (CdS) on Si NWs. Aberration-corrected transmission electron microscopy analysis shows that crystalline CdS is grown epitaxially on the {111} and {110} surface facets of the Si NWs but that the Si{113} facets remain bare. Further analysis of CdS on Si NWs grown at higher deposition rates to yield a conformal shell reveals a thin oxide layer on the Si{113} facet. This observation and control experiments suggest that facet-selective growth is enabled by the formation of an oxide, which prevents subsequent shell growth on the Si{113} NW facets. Further studies of facet-selective epitaxial growth of CdS shells on micro-to-mesoscale wires, which allows tuning of the lateral width of the compound semiconductor layer without lithographic patterning, and InP shell growth on Si NWs demonstrate the generality of our growth technique. In addition, photoluminescence imaging and spectroscopy show that the epitaxial shells display strong and clean band edge emission, confirming their high photonic quality, and thus suggesting that facet-selective epitaxy on NW substrates represents a promising route to integration of compound semiconductors on Si. PMID:26057208

  18. Facets for Discovery and Exploration in Text Collections

    SciTech Connect

    Rose, Stuart J.; Roberts, Ian E.; Cramer, Nicholas O.

    2011-10-24

    Faceted classifications of text collections provide a useful means of partitioning documents into related groups, however traditional approaches of faceting text collections rely on comprehensive analysis of the subject area or annotated general attributes. In this paper we show the application of basic principles for facet analysis to the development of computational methods for facet classification of text collections. Integration with a visual analytics system is described with summaries of user experiences.

  19. Results from Plasma Wakefield Experiments at FACET

    SciTech Connect

    Li, S.Z.; Clarke, C.I.; England, R.J.; Frederico, J.; Gessner, S.J.; Hogan, M.J.; Jobe, R.K.; Litos, M.D.; Walz, D.R.; Muggli, P.; An, W.; Clayton, C.E.; Joshi, C.; Lu, W.; Marsh, K.A.; Mori, W.; Tochitsky, S.; Adli, E.; /U. Oslo

    2011-12-13

    We report initial results of the Plasma Wakefield Acceleration (PWFA) Experiments performed at FACET - Facility for Advanced aCcelertor Experimental Tests at SLAC National Accelerator Laboratory. At FACET a 23 GeV electron beam with 1.8 x 10{sup 10} electrons is compressed to 20 {mu}m longitudinally and focused down to 10 {mu}m x 10 {mu}m transverse spot size for user driven experiments. Construction of the FACET facility completed in May 2011 with a first run of user assisted commissioning throughout the summer. The first PWFA experiments will use single electron bunches combined with a high density lithium plasma to produce accelerating gradients > 10 GeV/m benchmarking the FACET beam and the newly installed experimental hardware. Future plans for further study of plasma wakefield acceleration will be reviewed. The experimental hardware and operation of the plasma heat-pipe oven have been successfully commissioned. Plasma wakefield acceleration was not observed because the electron bunch density was insufficient to ionize the lithium vapor. The remaining commissioning time in summer 2011 will be dedicated to delivering the FACET design parameters for the experimental programs which will begin in early 2012. PWFA experiments require the shorter bunches and smaller transverse sizes to create the plasma and drive large amplitude wakefields. Low emittance and high energy will minimize head erosion which was found to be a limiting factor in acceleration distance and energy gain. We will run the PWFA experiments with the design single bunch conditions in early 2012. Future PWFA experiments at FACET are discussed in [5][6] and include drive and witness bunch production for high energy beam manipulation, ramped bunch to optimize tranformer ratio, field-ionized cesium plasma, preionized plasmas, positron acceleration, etc.. We will install a notch collimator for two-bunch operation as well as new beam diagnostics such as the X-band TCAV [7] to resolve the two bunches

  20. Does lumbar facet arthrosis precede disc degeneration? A postmortem study.

    PubMed

    Eubanks, Jason David; Lee, Michael J; Cassinelli, Ezequiel; Ahn, Nicholas U

    2007-11-01

    It is believed lumbar degeneration begins in the disc, where desiccation and collapse lead to instability and compensatory facet arthrosis. We explored the contrary contention that facet degeneration precedes disc degeneration by examining 647 skeletal lumbar spines. Using facet osteophytosis as a measure of facet degeneration and vertebral rim osteophytosis as a measure of disc degeneration, we assumed bone degeneration in both locations equally reflected the progression of those in the soft tissues. We graded arthrosis Grade 0 to 4 on a continuum from no arthritis to ankylosis. The data were analyzed for different age groups to examine patterns of degeneration with age. Specimens younger than 30 years of age had a higher prevalence of facet osteophytosis compared with vertebral rim osteophotosis at L1-L2 and L2-L3. Specimens aged 30 to 39 years showed more facet osteophytosis than vertebral rim osteophytosis at L4-L5. Specimens older than 40 years, however, showed more vertebral rim osteophytosis compared with facet osteophytosis at all levels except L4-L5 and L5-S1. This skeletal study suggests facet osteophytosis appears early in the degenerative process, preceding vertebral rim osteophytosis of degenerating intervertebral discs. However, once facets begin deteriorating with age, vertebral rim osteophytosis overtakes continued facet osteophytosis. These data challenge the belief that facet osteophytosis follows vertebral rim osteophytosis; rather, it appears vertebral rim osteophytosis progresses more rapidly in later years, but facet osteophotosis occurs early, predominating in younger individuals.

  1. Identifying Facets of Problem Solving in Mathematics Instruction.

    ERIC Educational Resources Information Center

    Klieme, Eckhard; Clausen, Marten

    Facets of problem solving instruction (PSI) were studied in German mathematics classrooms. Nine different facets of PSI were identified from the research literature, and a video rating form was developed to assess these facets and teacher effectiveness. Videotaped mathematics lessons (n=147) for German eighth graders from the sample for the Third…

  2. Surgical technique: hemi-extensor carpi radialis brevis tenodesis for stabilizing the midcarpal joint in Ehlers-Danlos syndrome.

    PubMed

    Krijgh, David D; Harley, Oliver J; Hovius, Steven E; Coert, J Henk; Walbeehm, Erik T

    2014-10-01

    Patients with the hypermobility type of Ehlers-Danlos (EDS-HT) often complain of wrist pain, usually originating from subluxations. As a result of the laxity, wrist function in these patients can be highly limited. This paper presents a surgical technique that stabilizes the lunocapitate joint with the use of an extensor carpi radialis brevis strip. Five patients with confirmed EDS-HT were treated with an extensor carpi radialis brevis tenodesis for their midcarpal instability. Two patients presented with complications following surgery, one major and one minor. This paper presents a potentially satisfactory surgical solution to recurrent midcarpal instability in EDS-HT patients and demonstrates that the use of an autologous tendon might be feasible in spite of a background of abnormal collagen metabolism. PMID:25194773

  3. Rough surface scattering based on facet model

    NASA Technical Reports Server (NTRS)

    Khamsi, H. R.; Fung, A. K.; Ulaby, F. T.

    1974-01-01

    A model for the radar return from bare ground was developed to calculate the radar cross section of bare ground and the effect of the frequency averaging on the reduction of the variance of the return. It is shown that, by assuming that the distribution of the slope to be Gaussian and that the distribution of the length of the facet to be in the form of the positive side of a Gaussian distribution, the results are in good agreement with experimental data collected by an 8- to 18-GHz radar spectrometer system. It is also shown that information on the exact correlation length of the small structure on the ground is not necessary; an effective correlation length may be calculated based on the facet model and the wavelength of the incident wave.

  4. How faceted liquid droplets grow tails

    PubMed Central

    Guttman, Shani; Sapir, Zvi; Schultz, Moty; Butenko, Alexander V.; Ocko, Benjamin M.; Deutsch, Moshe; Sloutskin, Eli

    2016-01-01

    Liquid droplets, widely encountered in everyday life, have no flat facets. Here we show that water-dispersed oil droplets can be reversibly temperature-tuned to icosahedral and other faceted shapes, hitherto unreported for liquid droplets. These shape changes are shown to originate in the interplay between interfacial tension and the elasticity of the droplet’s 2-nm-thick interfacial monolayer, which crystallizes at some T = Ts above the oil’s melting point, with the droplet’s bulk remaining liquid. Strikingly, at still-lower temperatures, this interfacial freezing (IF) effect also causes droplets to deform, split, and grow tails. Our findings provide deep insights into molecular-scale elasticity and allow formation of emulsions of tunable stability for directed self-assembly of complex-shaped particles and other future technologies. PMID:26733673

  5. How faceted liquid droplets grow tails.

    PubMed

    Guttman, Shani; Sapir, Zvi; Schultz, Moty; Butenko, Alexander V; Ocko, Benjamin M; Deutsch, Moshe; Sloutskin, Eli

    2016-01-19

    Liquid droplets, widely encountered in everyday life, have no flat facets. Here we show that water-dispersed oil droplets can be reversibly temperature-tuned to icosahedral and other faceted shapes, hitherto unreported for liquid droplets. These shape changes are shown to originate in the interplay between interfacial tension and the elasticity of the droplet's 2-nm-thick interfacial monolayer, which crystallizes at some T = Ts above the oil's melting point, with the droplet's bulk remaining liquid. Strikingly, at still-lower temperatures, this interfacial freezing (IF) effect also causes droplets to deform, split, and grow tails. Our findings provide deep insights into molecular-scale elasticity and allow formation of emulsions of tunable stability for directed self-assembly of complex-shaped particles and other future technologies. PMID:26733673

  6. Neurophysiological markers of multiple facets of impulsivity.

    PubMed

    Neal, Lauren B; Gable, Philip A

    2016-03-01

    Human behavior is influenced by three core personality systems: approach, avoidance, and supervisory control. The supervisory control system is inversely related to impulsivity. Although past research has related some aspects of impulsivity to frontal hemispheric asymmetry, impulsivity as a multi-faceted construct has not been studied in relation with frontal asymmetry. In addition, past work has potentially confounded impulsivity with approach-motivation. In the current study, greater relative left frontal activity was related to multiple facets of impulsivity: negative urgency, lack of premeditation, lack of perseverance, and positive urgency. Regressing both positive and negative urgency on frontal asymmetry revealed that approach-related positive urgency related to greater left frontal activity, but withdrawal-related negative urgency marginally related to greater right frontal activity. These results suggest that impulsivity, independent of affective valence, relates to greater left frontal activity. When controlling for trait approach motivation, the relationship between impulsivity and left frontal activity is unchanged.

  7. Zeroing In on Mindfulness Facets: Similarities, Validity, and Dimensionality across Three Independent Measures.

    PubMed

    Siegling, Alex B; Petrides, K V

    2016-01-01

    The field of mindfulness has seen a proliferation of psychometric measures, characterised by differences in operationalisation and conceptualisation. To illuminate the scope of, and offer insights into, the diversity apparent in the burgeoning literature, two distinct samples were used to examine the similarities, validity, and dimensionality of mindfulness facets and subscales across three independent measures: the Five Facet Mindfulness Questionnaire (FFMQ), Philadelphia Mindfulness Scale (PHLMS), and Toronto Mindfulness Scale (TMS). Results revealed problematic associations of FFMQ Observe with the other FFMQ facets and supported a four-factor structure (omitting this facet), while disputing the originally envisaged five-factor model; thus, solidifying a pattern in the literature. Results also confirmed the bidimensional nature of the PHLMS and TMS subscales, respectively. A joint Confirmatory Factor Analysis showed that PHLMS Acceptance could be assimilated within the FFMQ's four-factor model (as a distinct factor). The study offers a way of understanding interrelationships between the available mindfulness scales, so as to help practitioners and researchers make a more informed choice when conceptualising and operationalising mindfulness.

  8. Zeroing In on Mindfulness Facets: Similarities, Validity, and Dimensionality across Three Independent Measures.

    PubMed

    Siegling, Alex B; Petrides, K V

    2016-01-01

    The field of mindfulness has seen a proliferation of psychometric measures, characterised by differences in operationalisation and conceptualisation. To illuminate the scope of, and offer insights into, the diversity apparent in the burgeoning literature, two distinct samples were used to examine the similarities, validity, and dimensionality of mindfulness facets and subscales across three independent measures: the Five Facet Mindfulness Questionnaire (FFMQ), Philadelphia Mindfulness Scale (PHLMS), and Toronto Mindfulness Scale (TMS). Results revealed problematic associations of FFMQ Observe with the other FFMQ facets and supported a four-factor structure (omitting this facet), while disputing the originally envisaged five-factor model; thus, solidifying a pattern in the literature. Results also confirmed the bidimensional nature of the PHLMS and TMS subscales, respectively. A joint Confirmatory Factor Analysis showed that PHLMS Acceptance could be assimilated within the FFMQ's four-factor model (as a distinct factor). The study offers a way of understanding interrelationships between the available mindfulness scales, so as to help practitioners and researchers make a more informed choice when conceptualising and operationalising mindfulness. PMID:27055017

  9. Zeroing In on Mindfulness Facets: Similarities, Validity, and Dimensionality across Three Independent Measures

    PubMed Central

    Siegling, Alex B.; Petrides, K. V.

    2016-01-01

    The field of mindfulness has seen a proliferation of psychometric measures, characterised by differences in operationalisation and conceptualisation. To illuminate the scope of, and offer insights into, the diversity apparent in the burgeoning literature, two distinct samples were used to examine the similarities, validity, and dimensionality of mindfulness facets and subscales across three independent measures: the Five Facet Mindfulness Questionnaire (FFMQ), Philadelphia Mindfulness Scale (PHLMS), and Toronto Mindfulness Scale (TMS). Results revealed problematic associations of FFMQ Observe with the other FFMQ facets and supported a four-factor structure (omitting this facet), while disputing the originally envisaged five-factor model; thus, solidifying a pattern in the literature. Results also confirmed the bidimensional nature of the PHLMS and TMS subscales, respectively. A joint Confirmatory Factor Analysis showed that PHLMS Acceptance could be assimilated within the FFMQ’s four-factor model (as a distinct factor). The study offers a way of understanding interrelationships between the available mindfulness scales, so as to help practitioners and researchers make a more informed choice when conceptualising and operationalising mindfulness. PMID:27055017

  10. FACET: The New User Facility at SLAC

    SciTech Connect

    Clarke, C.I.; Decker, F.J.; Erikson, R.; Hast, C.; Hogan, M.J.; Iverson, R.; Li, S.Z.; Nosochkov, Y.; Phinney, N.; Sheppard, J.; Wienands, U.; Woodley, M.; Yocky, G.; Seryi, A.; Wittmer, W.; /Michigan State U.

    2011-12-13

    FACET (Facility for Advanced Accelerator and Experimental Tests) is a new User Facility at SLAC National Accelerator Laboratory. Its high power electron and positron beams make it a unique facility, ideal for beam-driven Plasma Wakefield Acceleration studies. The first 2 km of the SLAC linac produce 23 GeV, 3.2 nC electron and positron beams with short bunch lengths of 20 {mu}m. A final focusing system can produce beam spots 10 {mu}m wide. User-aided Commissioning took place in summer 2011 and FACET will formally come online in early 2012. We present the User Facility, the current features, planned upgrades and the opportunities for further experiments. Accelerators are our primary tool for discovering the fundamental laws to the universe. Each new frontier we probe requires a new, more powerful method. Accelerators are therefore increasing in size and cost. The future of this field requires new accelerating techniques that can reach the high energies required over shorter distances. New concepts for high gradient acceleration include utilizing the wakes in plasma and dielectric and metallic structures. FACET was built to provide a test bed for novel accelerating concepts with its high charge and highly compressed beams. As a test facility unlike any other, it has also attracted groups interested in beam diagnostic techniques and terahertz studies. The first phase of the construction was completed in May 2011. Beam commissioning began in June and was interleaved with the installation of five experiments. Users were invited to aid with the commissioning for the month of August during which time experimental hardware and software were checked out and some first measurements were taken. FACET is currently in the process of becoming a Department of Energy User Facility for High Energy Physics.

  11. Comparison of muscle and joint pressure-pain thresholds in patients with complex regional pain syndrome and upper limb pain of other origin.

    PubMed

    Mainka, Tina; Bischoff, Florian S; Baron, Ralf; Krumova, Elena K; Nicolas, Volkmar; Pennekamp, Werner; Treede, Rolf-Detlef; Vollert, Jan; Westermann, Andrea; Maier, Christoph

    2014-03-01

    Pain localized in the deep tissues occurs frequently in complex regional pain syndrome (CRPS). In addition, hyperalgesia to blunt pressure over muscles is common in CRPS, but it often appears in limb pain of other origin as well. Considering that 3-phase bone scintigraphy (TPBS) reveals periarticular enhanced bone metabolism in CRPS, joint-associated hyperalgesia to blunt pressure might be a more specific finding than hyperalgesia over muscles. In 34 patients with upper limb pain (18 CRPS, 16 non-CRPS; diagnosed in accordance to the Budapest criteria) and in 18 healthy controls, pressure-pain thresholds (PPT) were assessed bilaterally over the thenar (PPTThenar), the metacarpophalangeal (PPTMCP), and the proximal interphalangeal (PPTPIP) joints using a pressure algometer (Somedic, Sweden). Beforehand, all patients had received TPBS for diagnostic purposes independently of the study. Region-of-interest (ROI) ratios (mineralization phase) for the MCP and PIP, excluding fracture sites, were correlated with the PPT. In CRPS, all ROI ratios were significantly increased and all PPT of the affected hand were decreased compared to non-CRPS (PPTThenar: 243±150kPa vs 358±197kPa, PPTMCP: 80±67kPa vs 159±93kPa, PPTPIP: 80±56kPa vs 184±110kPa; P<.01) and controls (PPTThenar: 478±106kPa, PPTMCP: 254±50kPa, PPTPIP: 275±76kPa; P<.01). A PPTThenar below 293kPa revealed 77% sensitivity but only 63% specificity, whereas a PPTPIP below 102kPa had 82% sensitivity and 94% specificity to identify CRPS. Only in CRPS were PPTMCP and PPTPIP correlated significantly inversely with the ROI ratio (MCP: r=-0.439, PIP: r=-0.447). PPTPIP shows higher specificity for CRPS type I than PPTThenar without loss of sensitivity. Therefore, measurement of joint PPT could be a noninvasive diagnostic tool reflecting increased bone metabolism assessed by TPBS as a sign of bone pathophysiology.

  12. JPL tests of a LaJet concentrator facet

    SciTech Connect

    Dennison, E.W.; Argoud, M.J.

    1983-11-15

    A LaJet Energy Company (LEC) concentrator facet, 60 in. in diameter, was tested for imaging quality at the Jet Propulsion Laboratory using two methods: (1) autofocus tests with a point source of light at the facet's radius of curvature, and (2) tests with the sun close to the horizon as a distant source. These tests of the LaJet facet indicate that all of the solar image reflected by an LEC 460 solar concentrator made of like facets should fall within a 9-in. aperture if the outer facets are carefully adjusted. Such a concentrator would have acceptable performance, but complete evaluation must be made with an assembled concentrator.

  13. JPL tests of a LaJet concentrator facet

    SciTech Connect

    Dennison, E.W.; Argoud, M.J.

    1983-11-01

    A LaJet Energy Company (LEC) concentrator facet, 60 in. in diameter, was tested for imaging quality. The following two methods were used: (1) autofocus tests with a point source of light at the facet's radius of curvature and (2) tests with the Sun close to the horizon as a distant source. The tests of the LaJet facet indicate that all of the solar image reflected by an LEC 460 solar concentrator made of like facets should fall within a 9-in. aperture if the outer facets are carefully adjusted. Such a concentrator would have acceptable performance, but complete evaluation must be made with an assembled concentrator.

  14. High Stability of Faceted Nanotubes and Fullerenes of Multiphase Layered Phosphorus: A Computational Study.

    PubMed

    Guan, Jie; Zhu, Zhen; Tománek, David

    2014-11-28

    We present a paradigm in constructing very stable, faceted nanotube and fullerene structures by laterally joining nanoribbons or patches of different planar phosphorene phases. Our ab initio density functional calculations indicate that these phases may form very stable, nonplanar joints. Unlike fullerenes and nanotubes obtained by deforming a single-phase planar monolayer at substantial energy penalty, we find faceted fullerenes and nanotubes to be nearly as stable as the planar single-phase monolayers. The resulting rich variety of polymorphs allows us to tune the electronic properties of phosphorene nanotubes and fullerenes not only by the chiral index but also by the combination of different phosphorene phases. In selected phosphorene nanotubes, a metal-insulator transition may be induced by strain or by changing the number of walls.

  15. High stability of faceted nanotubes and fullerenes of multi-phase layered phosphorus: A computational study

    NASA Astrophysics Data System (ADS)

    Guan, Jie; Zhu, Zhen; Tomanek, David

    2015-03-01

    We present a paradigm in constructing very stable, faceted nanotube and fullerene structures by laterally joining nanoribbons or patches of different planar phosphorene phases. Our ab initio density functional calculations indicate that these phases may form very stable, non-planar joints. Unlike fullerenes and nanotubes obtained by deforming a single-phase planar monolayer at substantial energy penalty, we find faceted fullerenes and nanotubes to be nearly as stable as the planar single-phase monolayers. The resulting rich variety of polymorphs allows to tune the electronic properties of phosphorene nanotubes (PNTs) and fullerenes not only by the chiral index, but also by the combination of different phosphorene phases. In selected PNTs, a metal-insulator transition may be induced by strain or changing the number of walls. Supported by the National Science Foundation Cooperative Agreement #EEC-0832785, titled ``NSEC: Center for High-rate Nanomanufacturing.''

  16. High Stability of Faceted Nanotubes and Fullerenes of Multiphase Layered Phosphorus: A Computational Study

    NASA Astrophysics Data System (ADS)

    Guan, Jie; Zhu, Zhen; Tománek, David

    2014-11-01

    We present a paradigm in constructing very stable, faceted nanotube and fullerene structures by laterally joining nanoribbons or patches of different planar phosphorene phases. Our ab initio density functional calculations indicate that these phases may form very stable, nonplanar joints. Unlike fullerenes and nanotubes obtained by deforming a single-phase planar monolayer at substantial energy penalty, we find faceted fullerenes and nanotubes to be nearly as stable as the planar single-phase monolayers. The resulting rich variety of polymorphs allows us to tune the electronic properties of phosphorene nanotubes and fullerenes not only by the chiral index but also by the combination of different phosphorene phases. In selected phosphorene nanotubes, a metal-insulator transition may be induced by strain or by changing the number of walls.

  17. CT of facet distraction in flexion injuries of the thoracolumbar spine: the "naked" facet.

    PubMed

    O'Callaghan, J P; Ullrich, C G; Yuan, H A; Kieffer, S A

    1980-03-01

    Vertical distraction of the articular processes is an important sign of ligamentous disruption due to flexion injuries of the thoracolumbar spine. In addition to illustrating this finding in cross section (the "naked" facet), computed tomography in the transaxial plane allows assessment of the presence and position of fracture fragments that may encroach on the spinal canal. Image reconstruction in sagittal and coronal planes provides a clear demonstration of the degree of bony compression, facet distraction, and kyphosis associated with flexion injuries without additional patient manipulation or radiation exposure.

  18. Efficacy of needle-placement technique in radiofrequency ablation for treatment of lumbar facet arthropathy

    PubMed Central

    Loh, Jeffrey T; Nicol, Andrea L; Elashoff, David; Ferrante, F Michael

    2015-01-01

    Background Many studies have assessed the efficacy of radiofrequency ablation to denervate the facet joint as an interventional means of treating axial low-back pain. In these studies, varying procedural techniques were utilized to ablate the nerves that innervate the facet joints. To date, no comparison studies have been performed to suggest superiority of one technique or even compare the prevalence of side effects and complications. Materials and methods A retrospective chart review was performed on patients who underwent a lumbar facet denervation procedure. Each patient’s chart was analyzed for treatment technique (early versus advanced Australian), preprocedural visual numeric scale (VNS) score, postprocedural VNS score, duration of pain relief, and complications. Results Pre- and postprocedural VNS scores and change in VNS score between the two groups showed no significant differences. Patient-reported benefit and duration of relief was greater in the advanced Australian technique group (P=0.012 and 0.022, respectively). The advanced Australian technique group demonstrated a significantly greater median duration of relief (4 months versus 1.5 months, P=0.022). Male sex and no pain-medication use at baseline were associated with decreased postablation VNS scores, while increasing age and higher preablation VNS scores were associated with increased postablation VNS scores. Despite increasing age being associated with increased postablation VNS scores, age and the advanced Australian technique were found to confer greater patient self-reported treatment benefit. Conclusion The advanced Australian technique provides a significant benefit over the early Australian technique for the treatment of lumbar facet pain, both in magnitude and duration of pain relief. PMID:26504407

  19. [Facets of diagnostics of mentalization in children].

    PubMed

    Juen, Florian

    2014-01-01

    Clinical relevance of variations within the ability to mentalize is usually reported in the field of psychopathology in adults. This might be due to difficulties in methods for empirical assessment of this capacity in children. In this short report the author discusses facets and abilities of how to engage the inner world of young children with story stem techniques and especially how to register variations in the ability to mentalize. Ideas for assessment in early childhood are presented and illustrated along two clinical vignettes. This paper gives a short impression of clinical diagnostics of mentalization in childhood. PMID:25478751

  20. FIRO-B: factors and facets.

    PubMed

    Macrosson, W D

    2000-02-01

    10 FIRO-B intercorrelation matrices were factor analysed; one matrix was derived from new FIRO-B data, all the other matrices were found in the literature. The correlation matrices were also subjected to meta-analysis. The findings suggested that the four FIRO-B scales associated with Inclusion and Affection are facets of the ubiquitous interpersonal superfactor, Nurturance, but the two FIRO-B Control scales each express an orthogonal construct both of which relate to the super-factor, Dominance.

  1. Fabrication of faceted nanopores in magnesium

    SciTech Connect

    Wu, Shujing; Cao, Fan; Zheng, He; Sheng, Huaping; Liu, Chun; Liu, Yu; Zhao, Dongshan; Wang, Jianbo

    2013-12-09

    In this paper, using high resolution transmission electron microscopy, we showed the fabrication of faceted nanopores with various shapes in magnesium by focused electron beam (e-beam). The characteristics of nanopore shapes and the crystallographic planes corresponding to the edges of the nanopores were discussed in detail. Interestingly, by manipulating the e-beam (e.g., irradiation direction and duration), the nanopore shape and size could be effectively controlled along different directions. Our results provide important insight into the nanopore patterning in metallic materials and are of fundamental importance concerning the relevant applications, such as nanopore-based sensor, etc.

  2. Exercise in children with joint hypermobility syndrome and knee pain: a randomised controlled trial comparing exercise into hypermobile versus neutral knee extension

    PubMed Central

    2013-01-01

    Background Knee pain in children with Joint Hypermobility Syndrome (JHS) is traditionally managed with exercise, however the supporting evidence for this is scarce. No trial has previously examined whether exercising to neutral or into the hypermobile range affects outcomes. This study aimed to (i) determine if a physiotherapist-prescribed exercise programme focused on knee joint strength and control is effective in reducing knee pain in children with JHS compared to no treatment, and (ii) whether the range in which these exercises are performed affects outcomes. Methods A prospective, parallel-group, randomised controlled trial conducted in a tertiary hospital in Sydney, Australia compared an 8 week exercise programme performed into either the full hypermobile range or only to neutral knee extension, following a minimum 2 week baseline period without treatment. Randomisation was computer-generated, with allocation concealed by sequentially numbered opaque sealed envelopes. Knee pain was the primary outcome. Quality of life, thigh muscle strength, and function were also measured at (i) initial assessment, (ii) following the baseline period and (iii) post treatment. Assessors were blinded to the participants’ treatment allocation and participants blinded to the difference in the treatments. Results Children with JHS and knee pain (n=26) aged 7-16 years were randomly assigned to the hypermobile (n=12) or neutral (n=14) treatment group. Significant improvements in child-reported maximal knee pain were found following treatment, regardless of group allocation with a mean 14.5 mm reduction on the visual analogue scale (95% CI 5.2 – 23.8 mm, p=0.003). Significant differences between treatment groups were noted for parent-reported overall psychosocial health (p=0.009), specifically self-esteem (p=0.034), mental health (p=0.001) and behaviour (p=0.019), in favour of exercising into the hypermobile range (n=11) compared to neutral only (n=14). Conversely, parent

  3. Spontaneous septic arthritis of the lumbar facet caused by methicillin-resistant Staphylococcus aureus in an otherwise healthy adolescent.

    PubMed

    Papaliodis, Dean N; Roberts, Timothy T; Richardson, Nicholas G; Lawrence, James B

    2014-07-01

    We report the case of a 16-year-old boy with isolated septic arthritis of a lumbar facet. This rare presentation of an infection in a lumbar facet joint occurred after minor trauma sustained in a football game. Septic arthritis of the spinal facet joint is an uncommon phenomenon. Only 5 cases have been reported in immunocompromised pediatric patients. To our knowledge, no case of septic arthritis in an immunocompetent pediatric patient has been reported. An otherwise healthy 16-year-old boy presented with 4 weeks of escalating back pain after a minor athletics-related trauma. Evaluation showed incapacitating pain, lumbar musculature spasms, and the absence of fever, hemodynamic, or neurologic changes. Laboratory values were within normal limits. Magnetic resonance images showed a fluid collection within the L3-L4 facet and a localized abscess. Computed tomographic-guided aspiration showed methicillin-resistant Staphylococcus aureus infection, for which the patient received 6 weeks of vancomycin with complete resolution of symptoms. Refractory lumbago in an adolescent requires careful evaluation.

  4. Faceted ceramic fibers, tapes or ribbons and epitaxial devices therefrom

    SciTech Connect

    Goyal, Amit

    2013-07-09

    A crystalline article includes a single-crystal ceramic fiber, tape or ribbon. The fiber, tape or ribbon has at least one crystallographic facet along its length, which is generally at least one meter long. In the case of sapphire, the facets are R-plane, M-plane, C-plane or A-plane facets. Epitaxial articles, including superconducting articles, can be formed on the fiber, tape or ribbon.

  5. Faceted ceramic fibers, tapes or ribbons and epitaxial devices therefrom

    SciTech Connect

    Goyal, Amit

    2012-07-24

    A crystalline article includes a single-crystal ceramic fiber, tape or ribbon. The fiber, tape or ribbon has at least one crystallographic facet along its length, which is generally at least one meter long. In the case of sapphire, the facets are R-plane, M-plane, C-plane or A-plane facets. Epitaxial articles, including superconducting articles, can be formed on the fiber, tape or ribbon.

  6. Transverse effects in plasma wakefield acceleration at FACET - Simulation studies

    SciTech Connect

    Adli, E.; Hogan, M.; Frederico, J.; Litos, M. D.; An, W.; Mori, W.

    2012-12-21

    We investigate transverse effects in the plasma-wakefield acceleration experiments planned and ongoing at FACET. We use PIC simulation tools, mainly QuickPIC, to simulate the interaction of the drive electron beam and the plasma. In FACET a number of beam dynamics knobs, including dispersion and bunch length knobs, can be used to vary the beam transverse characteristics in the plasma. We present simulation results and the status of the FACET experimental searches.

  7. Faceted Gold Nanorods: Nanocuboids, Convex Nanocuboids, and Concave Nanocuboids.

    PubMed

    Zhang, Qingfeng; Zhou, Yadong; Villarreal, Esteban; Lin, Ye; Zou, Shengli; Wang, Hui

    2015-06-10

    Au nanorods are optically tunable anisotropic nanoparticles with built-in catalytic activities. The state-of-the-art seed-mediated nanorod synthesis offers excellent control over the aspect ratios of cylindrical Au nanorods, which enables fine-tuning of plasmon resonances over a broad spectral range. However, facet control of Au nanorods with atomic-level precision remains significantly more challenging. The coexistence of various types of low-index and high-index facets on the highly curved nanorod surfaces makes it extremely challenging to quantitatively elucidate the atomic-level structure-property relationships that underpin the catalytic competence of Au nanorods. Here we demonstrate that cylindrical Au nanorods undergo controlled facet evolution during their overgrowth in the presence of Cu(2+) and cationic surfactants, resulting in the formation of anisotropic nanostructures enclosed by well-defined facets, such as low-index faceting nanocuboids and high-index faceting convex nanocuboids and concave nanocuboids. These faceted Au nanorods exhibit enriched optical extinction spectral features, broader plasmonic tuning range, and enhanced catalytic tunability in comparison to the conventional cylindrical Au nanorods. The capabilities to both fine-tailor the facets and fine-tune the plasmon resonances of anisotropic Au nanoparticles open up unique opportunities for us to study, in great detail, the facet-dependent interfacial molecular transformations on Au nanocatalysts using surface-enhanced Raman scattering as a time-resolved spectroscopic tool. PMID:25927399

  8. Diagnostics Challenges for FACET-II

    SciTech Connect

    Clarke, Christine

    2015-10-07

    FACET-II is a prospective user facility at SLAC National Accelerator Laboratory. The facility will focus on high-energy, high-brightness beams and their interaction with plasma and lasers. The accelerator is designed for high-energy-density electron beams with peak currents of approximately 50 kA (potentially 100 kA) that are focused down to below 10x10 micron transverse spot size at an energy of 10 GeV. Subsequent phases of the facility will provide positron beams above 10 kA peak current to the experiment station. Experiments will require well characterised beams; however, the high peak current of the electron beam can lead to material failure in wirescanners, optical transition radiation screens and other instruments critical for measurement or delivery. The radiation environment and space constraints also put additional pressure on diagnostic design.

  9. Explorations in statistics: statistical facets of reproducibility.

    PubMed

    Curran-Everett, Douglas

    2016-06-01

    Learning about statistics is a lot like learning about science: the learning is more meaningful if you can actively explore. This eleventh installment of Explorations in Statistics explores statistical facets of reproducibility. If we obtain an experimental result that is scientifically meaningful and statistically unusual, we would like to know that our result reflects a general biological phenomenon that another researcher could reproduce if (s)he repeated our experiment. But more often than not, we may learn this researcher cannot replicate our result. The National Institutes of Health and the Federation of American Societies for Experimental Biology have created training modules and outlined strategies to help improve the reproducibility of research. These particular approaches are necessary, but they are not sufficient. The principles of hypothesis testing and estimation are inherent to the notion of reproducibility in science. If we want to improve the reproducibility of our research, then we need to rethink how we apply fundamental concepts of statistics to our science.

  10. Detecting the Multiple Facets of Biodiversity.

    PubMed

    Jarzyna, Marta A; Jetz, Walter

    2016-07-01

    Interest in, and opportunities to include functional and phylogenetic attributes of species in community ecology and biogeography are rapidly growing and seen as vital for the assessment of status and trends in biodiversity. However, the fundamental underlying evidence remains the (co-)occurrence of the biological units, such as species, in time and space and our ability to appropriately detect and quantify them. Here, we examine the implications of imperfect detection of species for functional and phylogenetic diversity (FD and PD) estimates. We explore how FD and PD might have different detectabilities than taxonomic diversity (TD) and how all three might vary differently along spatial and environmental gradients. We also extend occupancy modeling and dendrogram-based methods to address the imperfect detection of different biodiversity facets. PMID:27168115

  11. FACET Tolerances for Static and Dynamic Misalignments

    SciTech Connect

    Federico, Joel

    2012-07-13

    The Facility for AdvancedAccelerator and Experimental Tests (FACET) at the SLAC National Accelerator Laboratory is designed to deliver a beam with a transverse spot size on the order of 10 {micro}m x 10 {micro}m in a new beamline constructed at the two kilometer point of the SLAC linac. Commissioning the beamline requires mitigating alignment errors and their effects, which can be significant and result in spot sizes orders of magnitude larger. Sextupole and quadrupole alignment errors in particular can introduce errors in focusing, steering, and dispersion which can result in spot size growth, beta mismatch, and waist movement. Alignment errors due to static misalignments, mechanical jitter, energy jitter, and other physical processes can be analyzed to determine the level of accuracy and precision that the beamline requires. It is important to recognize these effects and their tolerances in order to deliver a beam as designed.

  12. Search Interface Design Using Faceted Indexing for Web Resources.

    ERIC Educational Resources Information Center

    Devadason, Francis; Intaraksa, Neelawat; Patamawongjariya, Pornprapa; Desai, Kavita

    2001-01-01

    Describes an experimental system designed to organize and provide access to Web documents using a faceted pre-coordinate indexing system based on the Deep Structure Indexing System (DSIS) derived from POPSI (Postulate based Permuted Subject Indexing) of Bhattacharyya, and the facet analysis and chain indexing system of Ranganathan. (AEF)

  13. The first tarsometatarsal joint and its association with hallux valgus

    PubMed Central

    Mason, L. W.; Tanaka, H.

    2012-01-01

    Introduction The aetiology of hallux valgus is almost certainly multifactoral. The biomechanics of the first ray is a common factor to most. There is very little literature examining the anatomy of the proximal metatarsal articular surface and its relationship to hallux valgus deformity. Methods We examined 42 feet from 23 specimens in this anatomical dissection study. Results This analysis revealed three distinct articular subtypes. Type 1 had one single facet, type 2 had two distinct articular facets, and type 3 had three articular facets one of which was a lateral inferior facet elevated from the first. Type 1 joints occurred exclusively in the hallux valgus specimens, while type 3 joints occurred exclusively in normal specimens. Type 2 joints occurred in both hallux valgus and normal specimens. Another consistent finding in regards to the proximal articular surface of the first metatarsal was the lateral plantar prominence. This prominence possessed its own articular surface in type 3 joints and was significantly flatter in specimens with hallux valgus (p < 0.001) and the angle with the joint was significantly more obtuse (p < 0.001). Conclusions We believe the size and acute angle of this prominence gives structural mechanical impedance to movement at the tarsometatarsal joint and thus improves the stability. PMID:23610678

  14. Prevalence of the metabolic syndrome in Luxembourg according to the Joint Interim Statement definition estimated from the ORISCAV-LUX study

    PubMed Central

    2011-01-01

    Background The prevalence of the metabolic syndrome (MS) has been determined in many countries worldwide but never in Luxembourg. This research aimed to 1) establish the gender- and age-specific prevalence of MS and its components in the general adult population of Luxembourg, according to the most recent Joint Interim Statement (JIS) definition, by using both the high and low cut-off points to define abdominal obesity, and 2) compare and assess the degree of agreement with the Revised National Cholesterol Education Programme-Adult Treatment Panel III (R-ATPIII) and the International Diabetes Federation (IDF) definitions. Methods A representative stratified random sample of 1349 European subjects, aged 18-69 years, participated to ORISCAV-LUX survey. Logistic regression and odds ratios (OR) were used to study MS prevalence with respect to gender and age. The Framingham risk score (FRS) to predict the 10-year coronary heart disease (CHD) risk was calculated to compare the proportion of MS cases below or above 20%, according to both high and low waist circumference (WC) thresholds. Cohen's kappa coefficient (κ) was utilized to measure the degree of agreement between MS definitions. Results The prevalence of the MS defined by the JIS was 28.0% and 24.7% when using the low (94/80) and the high (102/88) WC cut-off points, respectively. The prevalence was significantly higher in men than in women (OR = 2.6 and 2.3 for the low and high WC thresholds), as were all components of the MS except abdominal obesity measured by both thresholds. It also increased with age (OR values in age categories ranging from 2.7 to 28 when compared to the younger subjects for low WC and from 3.3 to 31 for the high WC cut-offs). The 10-year predicted risk of CHD by FRS did not depend on the threshold used. Globally, excellent agreement was observed between the three definitions of MS (κ= 0.89), in particular between JIS and IDF (κ = 0.93). Agreement was significantly higher in women than in

  15. The hamate facet of the lunate: a radiographic study in an Arab population from Bahrain.

    PubMed

    Dharap, A S; Al-Hashimi, H; Kassab, S; Abu-Hijleh, M F

    2006-05-01

    Based on the presence of a facet for the hamate two types of lunate bone have been described in the wrist; type I is without a facet for the hamate while type II bears a facet on the medial surface for articulation with the proximal pole of the hamate. Compared to type I lunates, type II lunates have been shown to have different kinematics, are more prone to clinically relevant degenerative changes in the hamato-lunate joint and may cause ulnar-sided wrist pain. The incidence of type II lunates seems to vary in different populations. Postero-anterior (PA) view of plain radiographs of the hand was studied in Arab subjects from Bahrain (n=381; 307 males and 74 females) to determine the incidence of type I and type II lunates. The mean age of the subjects was 31.1 years, the range being 18-80 years. In the population studied, only 148 (38.8%) of the 381 wrists showed type II lunate; 121 (31.7%) were found in males and 27 (7.1%) in females. There was no significant difference in the mean age of subjects with type I or type II lunates (P=0.16). There was no correlation between side and gender with the presence or absence of a hamate facet on the lunate. The incidence of type II lunate was much lower than reports in the literature of populations from the Western world, which could be attributed to a genetic variation in the Arab population in Bahrain. These data indicate that osteoarthritis of the hamate or lunate is less likely to be a cause of ulnar-sided wrist pain in Bahraini Arabs.

  16. Cervical facet dislocation adjacent to the fused motion segment.

    PubMed

    Yokoyama, Kunio; Kawanishi, Masahiro; Yamada, Makoto; Tanaka, Hidekazu; Ito, Yutaka; Kuroiwa, Toshihiko

    2016-01-01

    This study reports on a case that forces re-examination of merits and demerits of anterior cervical fusion. A 79-year-old male was brought to the emergency room (ER) of our hospital after he fell and struck the occipital region of his head following excessive alcohol consumption. Four years prior, he had undergone anterior cervical discectomy and fusion of C5/6 and a magnetic resonance imaging (MRI) performed 3 years after this surgery indicated that he was suffering from degeneration of C6/7 intervertebral discs. After arriving at the ER, he presented motor impairment at level C7 and lower of manual muscle testing grade 1 as well as moderate loss of physical sensation from the trunk and peripheries of both upper limbs to the peripheries of both lower limbs (Frankel B). Cervical computed tomography (CT) indicated anterior dislocation of C6/7, and MRI indicated severe spinal cord edema. We performed manipulative reduction of C6/7 with the patient under general anesthesia. Next, we performed laminectomy on C5-T1 and posterior fusion on C6/7. Postoperative CT indicated that cervical alignment had improved, and MRI indicated that the spinal cord edema observed prior to surgery had been mitigated. Three months after surgery, motor function and sensory impairment of the lower limbs had improved, and the patient was ambulatory upon discharge from the hospital (Frankel D). In the present case, although C5 and 6 were rigidly fused, degeneration of the C6/7 intervertebral disc occurred and stability was compromised. As a result, even slight trauma placed a severe dynamic burden on the facet joint of C6/7, which led to dislocation.

  17. The spreading of a void on a facet during electromigration

    SciTech Connect

    Chu, X.; Bauer, C.L.; Mullins, W.W.; Klinger, L.M.

    1997-07-01

    A void of cross sectional area A may spread perpendicular to the applied electric field E{sub a} during electromigration because its leading surface develops a facet whose advance is limited by the supply of steps. If the facet is immobile (no step source) and the remaining surface is free to move, and if E{sub a}A is less than a threshold value, then the void assumes a stationary elongated shape dictated by a balance between capillarity and electric field. If E{sub a}A exceeds the threshold value, however, a balance is no longer possible, and the void spreads along the facet without arrest. If the facet has limited mobility, a balance is possible for all values of E{sub a}A, resulting in an elongated moving steady-state shape. The treatment simplifies the void shape as rectangular but preserves the essential features of capillarity and surface electromigration. The authors argue that the motion of a facet on a void along the outward normal requires defects (e.g., intersecting screw dislocations) that act as step sources since homogeneous nucleation of steps on the facet is expected to be negligible. Since voids in fine-line interconnects are often observed to be partially faceted, restricted void motion and resultant spreading which depend sensitively on crystallographic features, such as defect structure and grain orientation, may indeed limit the lifetime of fine-line interconnects in electronic devices.

  18. Joint Disorders

    MedlinePlus

    A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including Arthritis - inflammation of a joint. It causes pain, stiffness, and swelling. Over time, ...

  19. Moiré superstructures of graphene on faceted nickel islands.

    PubMed

    Murata, Yuya; Petrova, Vania; Kappes, Branden B; Ebnonnasir, Abbas; Petrov, Ivan; Xie, Ya-Hong; Ciobanu, Cristian V; Kodambaka, Suneel

    2010-11-23

    Using scanning tunneling microscopy and spectroscopy, in combination with density functional theory calculations, we investigated the morphology and electronic structure of monolayer graphene grown on the (111) and (110) facets of three-dimensional nickel islands on highly oriented pyrolytic graphite substrate. We observed graphene domains exhibiting hexagonal and striped moiré patterns with periodicities of 22 and 12 Å, respectively, on (111) and (110) facets of the Ni islands. Graphene domains are also observed to grow, as single crystals, across adjacent facets and over facet boundaries. Scanning tunneling spectroscopy data indicate that the graphene layers are metallic on both Ni(111) and Ni(110), in agreement with the calculations. We attribute this behavior to a strong hybridization between the d-bands on Ni and the π-bands of carbon. Our findings point to the possibility of preparing large-area epitaxial graphene layers even on polycrystalline Ni substrates.

  20. Hydrothermal growth of multi-facet anatase spheres

    NASA Astrophysics Data System (ADS)

    Wu, Jin-Ming; Song, Xiao-Mei; Ma, Lu-Yao; Wei, Xiao-Dan

    2011-03-01

    Titania with various nanostructures can be synthesized by several F --mediated procedures. In this paper, we report the synthesis of a novel multi-facet microsphere consisting of etched single-crystalline anatase by simply immersing metallic Ti plates in an HF aqueous solution under hydrothermal conditions. The etched multi-facet sphere was found to grow through the nucleation and growth of truncated bipyramids on a previously precipitated one to assemble a microsphere, and its subsequent etching by HF to expose the thermodynamic stable {1 0 1} facets. The photocatalytic activity of such etched multi-facet sphere thin films was evaluated utilizing rhodamine B and sulfonic salicylic acid in water as target molecules and compared with commercial Degussa P25 titania nanoparticles.

  1. Correlation between crystallographic orientation and surface faceting in UO2

    NASA Astrophysics Data System (ADS)

    Miao, Yinbin; Mo, Kun; Yao, Tiankai; Lian, Jie; Fortner, Jeffrey; Jamison, Laura; Xu, Ruqing; Yacout, Abdellatif M.

    2016-09-01

    Here coordinated experimental efforts to quantitatively correlate crystallographic orientation and surface faceting features in UO2 are reported upon. A sintered polycrystalline UO2 sample was thermally etched to induce the formation of surface faceting features. Synchrotron Laue microdiffraction was used to obtain a precise crystallographic orientation map for the UO2 surface grains. Scanning electron microscopy (SEM) was utilized to collect the detailed information on the surface morphology of the sample. The surface faceting features were found to be highly dependent on the crystallographic orientation. In most cases, Triple-plane structures containing one {100} plane and two {111} planes were found to dominate the surface of UO2. The orientation-faceting relationship established in this study revealed a practical and efficient method of determining crystallographic orientation based on the surface features captured by SEM images.

  2. Framework Application for Core Edge Transport Simulation (FACETS)

    SciTech Connect

    Malony, Allen D; Shende, Sameer S; Huck, Kevin A; Mr. Alan Morris, and Mr. Wyatt Spear

    2012-03-14

    The goal of the FACETS project (Framework Application for Core-Edge Transport Simulations) was to provide a multiphysics, parallel framework application (FACETS) that will enable whole-device modeling for the U.S. fusion program, to provide the modeling infrastructure needed for ITER, the next step fusion confinement device. Through use of modern computational methods, including component technology and object oriented design, FACETS is able to switch from one model to another for a given aspect of the physics in a flexible manner. This enables use of simplified models for rapid turnaround or high-fidelity models that can take advantage of the largest supercomputer hardware. FACETS does so in a heterogeneous parallel context, where different parts of the application execute in parallel by utilizing task farming, domain decomposition, and/or pipelining as needed and applicable. ParaTools, Inc. was tasked with supporting the performance analysis and tuning of the FACETS components and framework in order to achieve the parallel scaling goals of the project. The TAU Performance System® was used for instrumentation, measurement, archiving, and profile / tracing analysis. ParaTools, Inc. also assisted in FACETS performance engineering efforts. Through the use of the TAU Performance System, ParaTools provided instrumentation, measurement, analysis and archival support for the FACETS project. Performance optimization of key components has yielded significant performance speedups. TAU was integrated into the FACETS build for both the full coupled application and the UEDGE component. The performance database provided archival storage of the performance regression testing data generated by the project, and helped to track improvements in the software development.

  3. Analysis on linac quadrupole misalignment in FACET commissioning 2012

    SciTech Connect

    Sun, Yipeng; /SLAC

    2012-07-05

    In this note, the analysis on linac quadrupole misalignment is presented for the FACET linac section LI05-09 plus LI11-19. The effectiveness of the beam-based alignment technique is preliminarily confirmed by the measurement. Beam-based alignment technique was adopted at SLAC linac since SLC time. Here the beam-based alignment algorithms are further developed and applied in the FACET commissioning during 2012 run.

  4. A diffuse interface model of grain boundary faceting

    NASA Astrophysics Data System (ADS)

    Abdeljawad, Fadi; Medlin, Douglas; Zimmerman, Jonathan; Hattar, Khalid; Foiles, Stephen

    Incorporating anisotropy into thermodynamic treatments of interfaces dates back to over a century ago. For a given orientation of two abutting grains in a pure metal, depressions in the grain boundary (GB) energy may exist as a function of GB inclination, defined by the plane normal. Therefore, an initially flat GB may facet resulting in a hill-and-valley structure. Herein, we present a diffuse interface model of GB faceting that is capable of capturing anisotropic GB energies and mobilities, and accounting for the excess energy due to facet junctions and their non-local interactions. The hallmark of our approach is the ability to independently examine the role of each of the interface properties on the faceting behavior. As a demonstration, we consider the Σ 5 < 001 > tilt GB in iron, where faceting along the { 310 } and { 210 } planes was experimentally observed. Linear stability analysis and numerical examples highlight the role of junction energy and associated non-local interactions on the resulting facet length scales. On the whole, our modeling approach provides a general framework to examine the spatio-temporal evolution of highly anisotropic GBs in polycrystalline metals. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. DOE's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  5. A diffuse interface model of grain boundary faceting

    NASA Astrophysics Data System (ADS)

    Abdeljawad, F.; Medlin, D. L.; Zimmerman, J. A.; Hattar, K.; Foiles, S. M.

    2016-06-01

    Interfaces, free or internal, greatly influence the physical properties and stability of materials microstructures. Of particular interest are the processes that occur due to anisotropic interfacial properties. In the case of grain boundaries (GBs) in metals, several experimental observations revealed that an initially flat GB may facet into hill-and-valley structures with well defined planes and corners/edges connecting them. Herein, we present a diffuse interface model that is capable of accounting for strongly anisotropic GB properties and capturing the formation of hill-and-valley morphologies. The hallmark of our approach is the ability to independently examine the various factors affecting GB faceting and subsequent facet coarsening. More specifically, our formulation incorporates higher order expansions to account for the excess energy due to facet junctions and their non-local interactions. As a demonstration of the modeling capability, we consider the Σ5 <001 > tilt GB in body-centered-cubic iron, where faceting along the {210} and {310} planes was experimentally observed. Atomistic calculations were utilized to determine the inclination-dependent GB energy, which was then used as an input in our model. Linear stability analysis and simulation results highlight the role of junction energy and associated non-local interactions on the resulting facet length scales. Broadly speaking, our modeling approach provides a general framework to examine the microstructural stability of polycrystalline systems with highly anisotropic GBs.

  6. Facet-selective photodeposition of gold nanoparticles on faceted ZnO crystals for visible light photocatalysis.

    PubMed

    Wang, Xuewen; Wang, Wuyou; Miao, Yuanquan; Feng, Gang; Zhang, Rongbin

    2016-08-01

    Hexagonal prism-like ZnO crystals dominated with polar facets were synthesized using a hydrothermal method. The Gold (Au) nanoparticles were selectively photodeposited on the polar surfaces of faceted ZnO crystals as a result of anisotropic photocatalytic activities of the polar and nonpolar facets. The size of Au nanoparticles uniformly dispersed on the polar facets increased with increasing Au-loading amount. These Au-loaded ZnO crystals showed an additional visible light absorption band from 400nm to 800nm. The 0.1wt% Au-loaded ZnO crystals with visible light absorption peak at approximately 690nm exhibited the highest photocatalytic activity under visible light irradiation.

  7. Facet-selective photodeposition of gold nanoparticles on faceted ZnO crystals for visible light photocatalysis.

    PubMed

    Wang, Xuewen; Wang, Wuyou; Miao, Yuanquan; Feng, Gang; Zhang, Rongbin

    2016-08-01

    Hexagonal prism-like ZnO crystals dominated with polar facets were synthesized using a hydrothermal method. The Gold (Au) nanoparticles were selectively photodeposited on the polar surfaces of faceted ZnO crystals as a result of anisotropic photocatalytic activities of the polar and nonpolar facets. The size of Au nanoparticles uniformly dispersed on the polar facets increased with increasing Au-loading amount. These Au-loaded ZnO crystals showed an additional visible light absorption band from 400nm to 800nm. The 0.1wt% Au-loaded ZnO crystals with visible light absorption peak at approximately 690nm exhibited the highest photocatalytic activity under visible light irradiation. PMID:27156091

  8. Structural Equation Modelling of Multiple Facet Data: Extending Models for Multitrait-Multimethod Data

    ERIC Educational Resources Information Center

    Bechger, Timo M.; Maris, Gunter

    2004-01-01

    This paper is about the structural equation modelling of quantitative measures that are obtained from a multiple facet design. A facet is simply a set consisting of a finite number of elements. It is assumed that measures are obtained by combining each element of each facet. Methods and traits are two such facets, and a multitrait-multimethod…

  9. Beyond Text Queries and Ranked Lists: Faceted Search in Library Catalogs

    ERIC Educational Resources Information Center

    Niu, Xi

    2012-01-01

    Since the adoption of faceted search in a small number of academic libraries in 2006, faceted library catalogs have gained popularity in many academic and public libraries. This dissertation seeks to understand whether faceted search improves the interactions between searchers and library catalogs and to understand ways that facets are used in…

  10. Many-Facet Rasch Model Selection Criteria: Examining Residuals and More.

    ERIC Educational Resources Information Center

    Schumacker, Randall E.

    This research examined the significance of facet selection in a multi-facet Rasch model analysis. The residuals or remaining error in a multi-facet Rasch model were further studied in the context of a full and reduced data-to-model fit chi-square, given the specific design. In addition, main effect facet contributions to person measures and the…

  11. [Systematization of the articular surfaces of the carpometacarpal joints (author's transl)].

    PubMed

    el Bacha, A; Maillot, C

    1977-01-01

    A study, done on 100 hands, of the systematization of the articular surfaces of the carpometacarpal joints, clearly delineates the variability of circumference, dimesions, and relief of the articular facets. An attempt to draw general conclusions from this morphological study, in terms of arthrokinetics, leads to an understanding of the nature of the joints and the movements that are performed at this site.

  12. High-Index Facets in Gold Nanocrystals Elucidated by Coherent Electron Diffraction

    PubMed Central

    Shah, Amish B.; Sivapalan, Sean T.; DeVetter, Brent M.; Yang, Timothy K.; Wen, Jianguo; Bhargava, Rohit; Murphy, Catherine J.; Zuo, Jian-Min

    2013-01-01

    Characterization of high index facets in noble metal nanocrystals for plasmonics and catalysis has been a challenge due to their small sizes and complex shapes. Here, we present an approach to determine the high index facets of nanocrystals using streaked Bragg reflections in coherent electron diffraction patterns, and provide a comparison of high index facets on unusual nanostructures such as trisoctahedra. We report new high index facets in trisoctahedra and previous unappreciated diversity in facet sharpness. PMID:23484620

  13. Simulation and optimization of faceted structure for illumination

    NASA Astrophysics Data System (ADS)

    Liu, Lihong; Engel, Thierry; Flury, Manuel

    2016-04-01

    The re-direction of incoherent light using a surface containing only facets with specific angular values is proposed. A new photometric approach is adopted since the size of each facet is large in comparison with the wavelength. A reflective configuration is employed to avoid the dispersion problems of materials. The irradiance distribution of the reflected beam is determined by the angular position of each facet. In order to obtain the specific irradiance distribution, the angular position of each facet is optimized using Zemax OpticStudio 15 software. A detector is placed in the direction which is perpendicular to the reflected beam. According to the incoherent irradiance distribution on the detector, a merit function needs to be defined to pilot the optimization process. The two dimensional angular position of each facet is defined as a variable which is optimized within a specified varying range. Because the merit function needs to be updated, a macro program is carried out to update this function within Zemax. In order to reduce the complexity of the manual operation, an automatic optimization approach is established. Zemax is in charge of performing the optimization task and sending back the irradiance data to Matlab for further analysis. Several simulation results are given for the verification of the optimization method. The simulation results are compared to those obtained with the LightTools software in order to verify our optimization method.

  14. Investigating facets of personality in adult pathological gamblers with ADHD

    PubMed Central

    Davtian, Margarit; Reid, Rory C; Fong, Timothy W

    2012-01-01

    SUMMARY The present study explored facets of personality in a sample of pathological gamblers with ADHD (n = 52) and without ADHD (n = 43). Participants were assessed for psychopathology and gambling disorders using the Mini International Neuropsychiatric Interview, the National Opinion Research Center DSM Screen for Gambling Problems, and the Adult ADHD Self-Report Scale. Facets of personality were assessed using the NEO Personality Inventory–Revised. Group differences emerged across several facets of personality when analyzed using multivariate statistics. Although both groups experienced difficulties in several areas compared with norming data (e.g., greater depression, higher impulsivity, lower self-esteem and lower self-discipline), these facets of personality were more pronounced in pathological gamblers with ADHD. Most notable among these differences are tendencies for gamblers with ADHD to experience greater levels of emotional instability, interpersonal sensitivity and stress proneness. Pathological gamblers with ADHD also appear to experience lower self-esteem, greater difficulty being assertive and lower levels of self-discipline. Surprisingly, both groups were comparable on facets of impulsivity. These findings suggest that pathological gamblers diagnosed with adult ADHD may experience additional challenges compared with pathological gamblers without ADHD. PMID:22815658

  15. Gold coverage and faceting of MBE grown silicon nanowires

    NASA Astrophysics Data System (ADS)

    David, Thomas; Roussel, Luc; Neisius, Thomas; Cabie, Martiane; Gailhanou, Marc; Alfonso, Claude

    2013-11-01

    In this paper, we investigate the faceting of molecular beam epitaxy (MBE) grown nanowires and the post-growth repartition of the gold used as catalyst. Electron microscopy analysis are performed using Scanning Transmission Electron Microscopy - High Angle Annular Dark Field (STEM-HAADF), electron tomography, and Energy-dispersive X-ray spectroscopy (EDS) to collect complementary information. The nanowires present very little to no faceting at the very top, very close to the catalyst, suggesting the nanowires grow with a quasi-circular section at the early stages of growth. The nanowires are then found to have an hexagonal and/or dodecagonal section and present a finer ‘saw-tooth’ faceting on the main faces. We find gold clusters spread on the surfaces of the nanowires, but we could not observe any gold inside the nanowires. Furthermore, the gold coverage is uneven on the different facets of the nanowire. The creation of these facets and the gold coverage are two linked phenomena balancing each other.

  16. Modeling of Anomalous Transport in Tokamaks with FACETS code

    NASA Astrophysics Data System (ADS)

    Pankin, A. Y.; Batemann, G.; Kritz, A.; Rafiq, T.; Vadlamani, S.; Hakim, A.; Kruger, S.; Miah, M.; Rognlien, T.

    2009-05-01

    The FACETS code, a whole-device integrated modeling code that self-consistently computes plasma profiles for the plasma core and edge in tokamaks, has been recently developed as a part of the SciDAC project for core-edge simulations. A choice of transport models is available in FACETS through the FMCFM interface [1]. Transport models included in FMCFM have specific ranges of applicability, which can limit their use to parts of the plasma. In particular, the GLF23 transport model does not include the resistive ballooning effects that can be important in the tokamak pedestal region and GLF23 typically under-predicts the anomalous fluxes near the magnetic axis [2]. The TGLF and GYRO transport models have similar limitations [3]. A combination of transport models that covers the entire discharge domain is studied using FACETS in a realistic tokamak geometry. Effective diffusivities computed with the FMCFM transport models are extended to the region near the separatrix to be used in the UEDGE code within FACETS. 1. S. Vadlamani et al. (2009) %First time-dependent transport simulations using GYRO and NCLASS within FACETS (this meeting).2. T. Rafiq et al. (2009) %Simulation of electron thermal transport in H-mode discharges Submitted to Phys. Plasmas.3. C. Holland et al. (2008) %Validation of gyrokinetic transport simulations using %DIII-D core turbulence measurements Proc. of IAEA FEC (Switzerland, 2008)

  17. Ceramic joints

    DOEpatents

    Miller, Bradley J.; Patten, Jr., Donald O.

    1991-01-01

    Butt joints between materials having different coefficients of thermal expansion are prepared having a reduced probability of failure of stress facture. This is accomplished by narrowing/tapering the material having the lower coefficient of thermal expansion in a direction away from the joint interface and not joining the narrow-tapered surface to the material having the higher coefficient of thermal expansion.

  18. Development of an improved mirror facet for space applications

    NASA Technical Reports Server (NTRS)

    Schertz, Paul; Saifee, Shabbar; Lammert, Luke

    1991-01-01

    A fabrication technique was successfully developed for a metallic aluminum honeycomb, high-accuracy, lightweight, and long-life solar concentrator (mirror) for Advanced Solar Dynamic Space Power Systems. The program scope was limited to the development, fabrication, evaluation, and delivery of a solar concentrator facet (petal) that was sized for a 2-meter deployable solar concentrator. A surface accuracy of 1.0 mrad was achieved. The development incorporated tooling design, material selection, facet forming, adhesive selection, testing, and analysis. Techniques for applying levelizing, reflective, and protective optical coatings were also developed.

  19. Temporomandibular Joint, Closed

    MedlinePlus

    ... Oral Health > The Temporomandibular Joint, Closed The Temporomandibular Joint, Closed Main Content Title: The Temporomandibular Joint, Closed Description: The temporomandibular joint connects the lower ...

  20. Reduction of rms-error in shallow faceted large space antennas

    NASA Technical Reports Server (NTRS)

    Fichter, W. B.

    1983-01-01

    This paper examines the potential for reducing root-mean-square surface error in shallow faceted reflectors by replacing flat facets with membrane facets. Exact solutions are obtained for the small lateral deflections of equilateral triangular and rectangular membranes subject to isotropic tension and parabolic edge deflections. These solutions are used to minimize the rms-error between a facet of a shallow paraboloidal surface and its approximating membrane facet. The resulting optimum placements and edge curvatures yield membrane facets which have significantly lower rms-errors than the corresponding best-fit flat facets. The rms-error reductions are about 55 percent for equilateral triangles and 25 percent to 93 percent for rectangles, depending on aspect ratio. The results suggest that the use of membrane facets conforming to curved structural members could yield reflectors with lower rms-error, or comparable error with larger facets and, hence, fewer structural members.

  1. The neuromuscular differential diagnosis of joint hypermobility.

    PubMed

    Donkervoort, S; Bonnemann, C G; Loeys, B; Jungbluth, H; Voermans, N C

    2015-03-01

    Joint hypermobility is the defining feature of various inherited connective tissue disorders such as Marfan syndrome and various types of Ehlers-Danlos syndrome and these will generally be the first conditions to be considered by geneticists and pediatricians in the differential diagnosis of a patient presenting with such findings. However, several congenital and adult-onset inherited myopathies also present with joint hypermobility in the context of often only mild-to-moderate muscle weakness and should, therefore, be included in the differential diagnosis of joint hypermobility. In fact, on the molecular level disorders within both groups represent different ends of the same spectrum of inherited extracellular matrix (ECM) disorders. In this review we will summarize the measures of joint hypermobility, illustrate molecular mechanisms these groups of disorders have in common, and subsequently discuss the clinical features of: 1) the most common connective tissue disorders with myopathic or other neuromuscular features: Ehlers-Danlos syndrome, Marfan syndrome and Loeys-Dietz syndrome; 2) myopathy and connective tissue overlap disorders (muscle extracellular matrix (ECM) disorders), including collagen VI related dystrophies and FKBP14 related kyphoscoliotic type of Ehlers-Danlos syndrome; and 3) various (congenital) myopathies with prominent joint hypermobility including RYR1- and SEPN1-related myopathy. The aim of this review is to assist clinical geneticists and other clinicians with recognition of these disorders. PMID:25821091

  2. Bertolotti Syndrome: A Diagnostic and Management Dilemma for Pain Physicians

    PubMed Central

    Agarwal, Anil; Jain, Suruchi; Shamshery, Chetna

    2013-01-01

    Background Bertolotti's syndrome (BS), a form of lumbago in lumbosacral transitional vertebrae, is an important cause of low back pain in young patients. The purpose of this study was to assess the etiology of low back pain and the efficacy of treatment offered to patients with BS. Methods All patients of BS Castellvi type1a during a period of 6 months were enrolled in the study. The patients underwent interventional pain procedures for diagnosis and pain relief. Response to the therapy was assessed based on VAS and ODI scores. A 50% decrease in VAS score or a VAS score less than 3 would be considered adequate pain relief. Results All 20 patients diagnosed with BS during the 6-month observation period had scoliosis. Common causes of back pain were the ipsilateral L5-S1 facet joint, neoarticulation, the SI joint, and disc degeneration. Responses to various interventions for pain relief were different and inconsistent from patient to patient. In particular, responses to interventions for neoarticular pain were generally poor. Conclusions Pain in patients with BS does not usually respond to interventional pain treatment. A very dynamic treatment approach must be pursued while managing BS patients, and the treatment plan must be individualized at various stages in order to obtain satisfactory pain relief. PMID:24156003

  3. Compliant joint

    NASA Technical Reports Server (NTRS)

    Eklund, Wayne D. (Inventor); Kerley, James J. (Inventor)

    1990-01-01

    A compliant joint is provided for prosthetic and robotic devices which permits rotation in three different planes. The joint provides for the controlled use of cable under motion. Perpendicular outer mounting frames are joined by swaged cables that interlock at a center block. Ball bearings allow for the free rotation of the second mounting frame relative to the first mounting frame within a predetermined angular rotation that is controlled by two stop devices. The cables allow for compliance at the stops and the cables allow for compliance in six degrees of freedom enabling the duplication or simulation of the rotational movement and flexibility of a natural hip or knee joint, as well as the simulation of a joint designed for a specific robotic component for predetermined design parameters.

  4. Joint Commission

    MedlinePlus

    ... Sunday 1:00 CST, November 6, 2016 Workplace Violence Prevention Resources The Joint Commission has launched “Workplace Violence Prevention Resources,” an online resource center dedicated to ...

  5. Joint Problems

    MedlinePlus

    ... ankles and toes. Other types of arthritis include gout or pseudogout. Sometimes, there is a mechanical problem ... for more information on osteoarthritis, rheumatoid arthritis and gout. How Common are Joint Problems? Osteoarthritis, which affects ...

  6. Beyond Conflict: Functional Facets of the Work-Family Interplay

    ERIC Educational Resources Information Center

    Wiese, Bettina S.; Seiger, Christine P.; Schmid, Christian M.; Freund, Alexandra M.

    2010-01-01

    The present paper deals with three positive facets of the work-family interplay, i.e., transfer of competencies, transfer of positive mood, and cross-domain compensation. The latter refers to the experience that engagement in one domain helps dealing with failures in the other domain. In two correlational studies (N[subscript 1] = 107 working…

  7. Hinge specification for a square-faceted tetrahedral truss

    NASA Technical Reports Server (NTRS)

    Adams, L. R.

    1984-01-01

    A square-faceted tetrahedral truss is geometrically analyzed. Expressions are developed for single degree of freedom hinges which allow packaging of the structure into a configuration in which all members are parallel and closely packed in a square pattern. Deployment is sequential, thus providing control over the structure during deployment.

  8. Progress of plasma wakefield self-modulation experiments at FACET

    NASA Astrophysics Data System (ADS)

    Adli, E.; Berglyd Olsen, V. K.; Lindstrøm, C. A.; Muggli, P.; Reimann, O.; Vieira, J. M.; Amorim, L. D.; Clarke, C. I.; Gessner, S. J.; Green, S. Z.; Hogan, M. J.; Litos, M. D.; O`Shea, B. D.; Yakimenko, V.; Clayton, C.; Marsh, K. A.; Mori, W. B.; Joshi, C.; Vafaei-Najafabadi, N.; Williams, O.

    2016-09-01

    Simulations and theory predict that long electron and positron beams may under favorable conditions self-modulate in plasmas. We report on the progress of experiments studying the self-modulation instability in plasma wakefield experiments at FACET. The experimental results obtained so far, while not being fully conclusive, appear to be consistent with the presence of the self-modulation instability.

  9. Transverse oscillations in plasma wakefield experiments at FACET

    NASA Astrophysics Data System (ADS)

    Adli, E.; Lindstrøm, C. A.; Allen, J.; Clarke, C. I.; Frederico, J.; Gessner, S. J.; Green, S. Z.; Hogan, M. J.; Litos, M. D.; White, G. R.; Yakimenko, V.; An, W.; Clayton, C. E.; Marsh, K. A.; Mori, W. B.; Joshi, C.; Vafaei-Najafabadi, N.; Corde, S.; Lu, W.

    2016-09-01

    We study transverse effects in a plasma wakefield accelerator. Experimental data from FACET with asymmetry in the beam-plasma system is presented. Energy dependent centroid oscillations are observed on the accelerated part of the charge. The experimental results are compared to PIC simulations and theoretical estimates.

  10. Empirical Identification of the Major Facets of Conscientiousness

    ERIC Educational Resources Information Center

    MacCann, Carolyn; Duckworth, Angela Lee; Roberts, Richard D.

    2009-01-01

    Conscientiousness is often found to predict academic outcomes, but is defined differently by different models of personality. High school students (N = 291) completed a large number of Conscientiousness items from different models and the Big Five Inventory (BFI). Exploratory and confirmatory factor analysis of the items uncovered eight facets:…

  11. Aspects of faceting in the study of percipitate interfaces

    SciTech Connect

    Dahmen, U.; Witcomb, M.J.; Westmacott, K.H.

    1989-07-01

    The role of faceting in the formation of interface structures between a precipitate and its matrix is considered and illustrated with TEM observations on a number of different alloy systems. Crystal symmetry and elastic constraints from the solid matrix are shown to be important factors in the development of morphologies and interfacial structures. 14 refs., 9 figs.

  12. Conceptualizing Educational Leadership: Does Exploring Macro-Level Facets Matters?

    ERIC Educational Resources Information Center

    Sinha, Chetan

    2013-01-01

    The present review attempts to examine the present status of educational leadership highlighting the role of macro-level facets in Asian Pacific context. The conceptualization of educational leadership among researchers so far had been found to vary according to different contexts and situations. Theoretical perspectives associated with…

  13. Personality Facets and RIASEC Interests: An Integrated Model

    ERIC Educational Resources Information Center

    Armstrong, Patrick Ian; Anthoney, Sarah Fetter

    2009-01-01

    Research examining links between personality and interest have typically focused on links between measures of the five factor model and Holland's RIASEC types. However, the five factor model of personality can be divided in to a larger set of narrow domain personality scales measuring facets of the "big five" traits. Research in a number of fields…

  14. Attention to Faces in Williams Syndrome

    ERIC Educational Resources Information Center

    Riby, Deborah M.; Jones, Nicola; Brown, Philippa H.; Robinson, Lucy J.; Langton, Stephen R. H.; Bruce, Vicki; Riby, Leigh M.

    2011-01-01

    Williams syndrome (WS) is associated with distinct social behaviours. One component of the WS social phenotype is atypically prolonged face fixation. This behaviour co-exists with attention difficulties. Attention is multi-faceted and may impact on gaze behaviour in several ways. Four experiments assessed (i) attention capture by faces, (ii)…

  15. Terahertz Light Source and User Area at FACET

    SciTech Connect

    Wu, Z.; Li, S.Z.; Litos, M.; Fisher, A.D.; Hogan, M.J.; /SLAC

    2011-11-08

    FACET at SLAC provides high charge, high peak current, low emittance electron beam that is bunched at THz wavelength scale during its normal operation. A THz light source based coherent transition radiation (CTR) from this beam would potentially be the brightest short-pulse THz source ever constructed. Efforts have been put into building this photon source together with a user area, to provide a platform to utilize this unique THz radiation for novel nonlinear and ultrafast phenomena researches and experiments. Being a long-time underutilized portion of the electromagnetic spectrum, terahertz (100 GHz {approx} 10 THz) spectral range is experiencing a renaissance in recent years, with broad interests from chemical and biological imaging, material science, telecommunication, semiconductor and superconductor research, etc. Nevertheless, the paucity of THz sources especially strong THz radiation hinders both its commercial applications and nonlinear processes research. FACET - Facilities for Accelerator science and Experimental Test beams at SLAC - provides 23 GeV electron beam with peak currents of {approx} 20 kA that can be focused down to 100 {mu}m{sup 2} transversely. Such an intense electron beam, when compressed to sub-picosecond longitudinal bunch length, coherently radiates high intensity EM fields well within THz frequency range that are orders of magnitude stronger than those available from laboratory tabletop THz sources, which will enable a wide variety of THz related research opportunities. Together with a description of the FACET beamline and electron beam parameters, this paper will report FACET THz radiation generation via coherent transition radiation and calculated photon yield and power spectrum. A user table is being set up along the THz radiation extraction sites, and equipped with various signal diagnostics including THz power detector, Michelson interferometer, sample stages, and sets of motorized optical components. This setup will also be

  16. Chemical changes accompanying facet degradation of AlGaAs quantum well lasers

    NASA Astrophysics Data System (ADS)

    Houle, F. A.; Neiman, D. L.; Tang, W. C.; Rosen, H. J.

    1992-11-01

    Detailed measurements are reported using high-resolution scanning Auger microscopy of the chemical state of uncoated quantum well (QW) laser facets after brief and intermediate operating times. Analyses or uncoated facets which have suffered catastrophic optical damage (COD) under various operating conditions are described. The data show clearly that initial facet compositions are variable and far from ideal. After operation for as little as 2-10 min, the composition of the facet regions of the active/graded index and cladding layer change markedly, but no single type of change can be linked to COD. In particular, facet oxidation is not uniform or extensive, and facets which suffer COD are not necessarily more oxidized than those which have not. Composition changes are not limited to the facet surface, indicating that elemental redistribution during laser operation is very fast. These results suggest that the process of facet degradation plays a complex role in laser degradation.

  17. CANDLE syndrome: a recently described autoinflammatory syndrome.

    PubMed

    Tüfekçi, Özlem; Bengoa, ŞebnemYilmaz; Karapinar, Tuba Hilkay; Ataseven, Eda Büke; İrken, Gülersu; Ören, Hale

    2015-05-01

    CANDLE syndrome (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature) is a recently described autoinflammatory syndrome characterized by early onset, recurrent fever, skin lesions, and multisystemic inflammatory manifestations. Most of the patients have been shown to have mutation in PSMB8 gene. Herein, we report a 2-year-old patient with young onset recurrent fever, atypical facies, widespread skin lesions, generalized lymphadenopathy, hepatosplenomegaly, joint contractures, hypertrglyceridemia, lipodystrophy, and autoimmune hemolytic anemia. Clinical features together with the skin biopsy findings were consistent with the CANDLE syndrome. The pathogenesis and treatment of this syndrome have not been fully understood. Increased awareness of this recently described syndrome may lead to recognition of new cases and better understanding of its pathogenesis which in turn may help for development of an effective treatment. PMID:25036278

  18. [Divorce and joint physical custody].

    PubMed

    Golse, B

    2014-04-01

    This work first recalls the definition of joint physical custody, as well as the current legal procedure for obtaining it, its practical implementation, the financial implications for parents, and finally some statistics. Some psychological and psychopathological reflections on the impact of divorce on children are then presented before considering the question of joint physically custody with regard to attachment theory and depending on the age of the child (a great caution seems to be required before three years). The article concludes with a brief discussion of parental alienation syndrome. PMID:24630624

  19. [Divorce and joint physical custody].

    PubMed

    Golse, B

    2014-04-01

    This work first recalls the definition of joint physical custody, as well as the current legal procedure for obtaining it, its practical implementation, the financial implications for parents, and finally some statistics. Some psychological and psychopathological reflections on the impact of divorce on children are then presented before considering the question of joint physically custody with regard to attachment theory and depending on the age of the child (a great caution seems to be required before three years). The article concludes with a brief discussion of parental alienation syndrome.

  20. Morphological Traits Around Patellofemoral Joint in Indian Femora and their Implications

    PubMed Central

    Ghosh, Suchismita; Vasudeva, Neelam

    2014-01-01

    Introduction: Knowledge of structural variations around patellofemoral joint has helped to understand postural behavior patterns of various population groups. The biomechanical impact of postures may lead to certain skeletal modifications which may contribute to knee pathologies like patellofemoral arthritis, patellar subluxation and trochlear dysplasia. This study was conducted to report the incidence of skeletal non-metric markers on femur in Indian population and to understand their correlation with some pathologies of patellofemoral joint. The traits studied were Martin’s facet, Peritrochlear groove and Supratrochlear facet. Materials and Methods: The study material was a collection of 152 adult femora from osteology museum in Department of Anatomy, Maulana Azad Medical College, New Delhi, India, with equal percentage of bones from each side and gender. All bones were evaluated for the above mentioned traits and results were obtained as percentage of incidence and Chi-Square test using SPSS version 17. Results: The data showed that Martin’s facet and Peritrochlear groove showed a higher occurrence in male femora. However, Supratrochlear facet was more commonly found in female bones. Martin’s facet had an equal incidence on femora of each side while peritrochlear groove and supratrochlear facet had higher percentage of occurrence on right side. Supratrochlear facet revealed significant side variation. Conclusion: These data suggest that casual or occupational postures may impose structural adaptations around patell- ofemoral joint. The stress of these postures may have causal,consequential or co-incidental relationship with joint pathologies. The gender, special occupations like sports and genetic predisposition may possibly have a role to play. PMID:25302179

  1. Morphology of facets on vapor-grown AIN crystals

    NASA Astrophysics Data System (ADS)

    Yakovlev, N. L.; Rojo, J. C.; Schowalter, L. J.

    2001-11-01

    Single crystals of AlN were grown using the sublimation-recondensation method. On the Al-terminated surface, (0 0 1) and (1 1 3) facets were observed. On the basal plane facets, step flow growth was revealed by atomic force microscopy measured after the growth. The steps were one molecular layer high and were arranged in spirals near the outlets of screw dislocations, but consisted of straight segments along the < 1¯ 1 0> directions on the most of the surface. We discuss the shape of the steps as the result of competing processes: re-evaporation of deposited species and their diffusion along the steps. An estimation of the activation energy for diffusion of Al atoms along th steps gave approximately 0.5 eV.

  2. The role of surface passivation in controlling Ge nanowire faceting

    DOE PAGESBeta

    Gamalski, A. D.; Tersoff, J.; Kodambaka, S.; Zakharov, D. N.; Ross, F. M.; Stach, E. A.

    2015-11-05

    In situ transmission electron microscopy observations of nanowire morphologies indicate that during Au-catalyzed Ge nanowire growth, Ge facets can rapidly form along the nanowire sidewalls when the source gas (here, digermane) flux is decreased or the temperature is increased. This sidewall faceting is accompanied by continuous catalyst loss as Au diffuses from the droplet to the wire surface. We suggest that high digermane flux and low temperatures promote effective surface passivation of Ge nanowires with H or other digermane fragments inhibiting diffusion and attachment of Au and Ge on the sidewalls. Furthermore, these results illustrate the essential roles of themore » precursor gas and substrate temperature in maintaining nanowire sidewall passivation, necessary to ensure the growth of straight, untapered, <111>-oriented nanowires.« less

  3. The role of surface passivation in controlling Ge nanowire faceting

    SciTech Connect

    Gamalski, A. D.; Tersoff, J.; Kodambaka, S.; Zakharov, D. N.; Ross, F. M.; Stach, E. A.

    2015-11-05

    In situ transmission electron microscopy observations of nanowire morphologies indicate that during Au-catalyzed Ge nanowire growth, Ge facets can rapidly form along the nanowire sidewalls when the source gas (here, digermane) flux is decreased or the temperature is increased. This sidewall faceting is accompanied by continuous catalyst loss as Au diffuses from the droplet to the wire surface. We suggest that high digermane flux and low temperatures promote effective surface passivation of Ge nanowires with H or other digermane fragments inhibiting diffusion and attachment of Au and Ge on the sidewalls. Furthermore, these results illustrate the essential roles of the precursor gas and substrate temperature in maintaining nanowire sidewall passivation, necessary to ensure the growth of straight, untapered, <111>-oriented nanowires.

  4. Faceting and commensurability in crystal structures of colloidal thin films.

    PubMed

    Ramiro-Manzano, F; Meseguer, F; Bonet, E; Rodriguez, I

    2006-07-14

    This Letter investigates the influence of finite size effects on the particle arrangement of thin film colloidal crystals. A rich variety of crystallographic faceting with large single domain microcrystallites is shown. Optical reflectance experiments together with scanning electron microscopy permit the identification of the crystal symmetry and the facet orientation, as well as the exact number of monolayers. When the cell thickness is not commensurable with a high symmetry layering, particles arrange themselves in a periodic distribution of (111)- and (100)-orientated face centered cubic (fcc) microcrystallites separated by planar defects. These structures can be described as a fcc ordering orientated along a vicinal surface, modified by a periodic distribution of fcc (111) stacking faults.

  5. The Role of Surface Passivation in Controlling Ge Nanowire Faceting.

    PubMed

    Gamalski, A D; Tersoff, J; Kodambaka, S; Zakharov, D N; Ross, F M; Stach, E A

    2015-12-01

    In situ transmission electron microscopy observations of nanowire morphologies indicate that during Au-catalyzed Ge nanowire growth, Ge facets can rapidly form along the nanowire sidewalls when the source gas (here, digermane) flux is decreased or the temperature is increased. This sidewall faceting is accompanied by continuous catalyst loss as Au diffuses from the droplet to the wire surface. We suggest that high digermane flux and low temperatures promote effective surface passivation of Ge nanowires with H or other digermane fragments inhibiting diffusion and attachment of Au and Ge on the sidewalls. These results illustrate the essential roles of the precursor gas and substrate temperature in maintaining nanowire sidewall passivation, necessary to ensure the growth of straight, untapered, ⟨111⟩-oriented nanowires. PMID:26539668

  6. Faceting and commensurability in crystal structures of colloidal thin films.

    PubMed

    Ramiro-Manzano, F; Meseguer, F; Bonet, E; Rodriguez, I

    2006-07-14

    This Letter investigates the influence of finite size effects on the particle arrangement of thin film colloidal crystals. A rich variety of crystallographic faceting with large single domain microcrystallites is shown. Optical reflectance experiments together with scanning electron microscopy permit the identification of the crystal symmetry and the facet orientation, as well as the exact number of monolayers. When the cell thickness is not commensurable with a high symmetry layering, particles arrange themselves in a periodic distribution of (111)- and (100)-orientated face centered cubic (fcc) microcrystallites separated by planar defects. These structures can be described as a fcc ordering orientated along a vicinal surface, modified by a periodic distribution of fcc (111) stacking faults. PMID:16907485

  7. Nonjudging facet of mindfulness predicts enhanced smoking cessation in Hispanics.

    PubMed

    Spears, Claire Adams; Houchins, Sean C; Stewart, Diana W; Chen, Minxing; Correa-Fernández, Virmarie; Cano, Miguel Ángel; Heppner, Whitney L; Vidrine, Jennifer I; Wetter, David W

    2015-12-01

    Although most smokers express interest in quitting, actual quit rates are low. Identifying strategies to enhance smoking cessation is critical, particularly among underserved populations, including Hispanics, for whom many of the leading causes of death are related to smoking. Mindfulness (purposeful, nonjudgmental attention to the present moment) has been linked to increased likelihood of cessation. Given that mindfulness is multifaceted, determining which aspects of mindfulness predict cessation could help to inform interventions. This study examined whether facets of mindfulness predict cessation in 199 Spanish-speaking smokers of Mexican heritage (63.3% male, mean age of 39 years, 77.9% with a high school education or less) receiving smoking cessation treatment. Primary outcomes were 7-day abstinence at weeks 3 and 26 postquit (biochemically confirmed and determined using an intent-to-treat approach). Logistic random coefficient regression models were utilized to examine the relationship between mindfulness facets and abstinence over time. Independent variables were subscales of the Five Facet Mindfulness Questionnaire (Observing, Describing, Acting With Awareness, Nonjudging, and Nonreactivity). The Nonjudging subscale (i.e., accepting thoughts and feelings without evaluating them) uniquely predicted better odds of abstinence up to 26 weeks postquit. This is the first known study to examine whether specific facets of mindfulness predict smoking cessation. The ability to experience thoughts, emotions, and withdrawal symptoms without judging them may be critical in the process of quitting smoking. Results indicate potential benefits of mindfulness among smokers of Mexican heritage and suggest that smoking cessation interventions might be enhanced by central focus on the Nonjudging aspect of mindfulness.

  8. Nonjudging Facet of Mindfulness Predicts Enhanced Smoking Cessation in Hispanics

    PubMed Central

    Spears, Claire Adams; Houchins, Sean C.; Stewart, Diana W.; Chen, Minxing; Correa-Fernández, Virmarie; Cano, Miguel Ángel; Heppner, Whitney L.; Vidrine, Jennifer I.; Wetter, David W.

    2015-01-01

    Although most smokers express interest in quitting, actual quit rates are low. Identifying strategies to enhance smoking cessation is critical, particularly among underserved populations including Hispanics, for whom many of the leading causes of death are related to smoking. Mindfulness (purposeful, non-judgmental attention to the present moment) has been linked to increased likelihood of cessation. Given that mindfulness is multifaceted, determining which aspects of mindfulness predict cessation could help to inform interventions. This study examined whether facets of mindfulness predict cessation in 199 Spanish-speaking smokers of Mexican heritage (63.3% male, mean age=39, 77.9% ≤ high school education) receiving smoking cessation treatment. Primary outcomes were 7-day abstinence at weeks 3 and 26 post-quit (biochemically-confirmed and determined using an intent-to-treat approach). Logistic random coefficients regression models were utilized to examine the relationship between mindfulness facets and abstinence over time. Independent variables were subscales of the Five Facet Mindfulness Questionnaire (Observing, Describing, Acting with Awareness, Nonjudging, Nonreactivity). The Nonjudging subscale (i.e., accepting thoughts and feelings without evaluating them) uniquely predicted better odds of abstinence up to 26 weeks post-quit. This is the first known study to examine whether specific facets of mindfulness predict smoking cessation. The ability to experience thoughts, emotions, and withdrawal symptoms without judging them may be critical in the process of quitting smoking. Results indicate potential benefits of mindfulness among smokers of Mexican heritage and suggest that smoking cessation interventions might be enhanced by central focus on the Nonjudging aspect of mindfulness. PMID:25961148

  9. Extraversion and psychopathology: A facet-level analysis.

    PubMed

    Watson, David; Stasik, Sara M; Ellickson-Larew, Stephanie; Stanton, Kasey

    2015-05-01

    The goal of this study was to explicate how the lower order facets of extraversion are related to psychopathology. We used a "bottom-up" approach in which specific extraversion scales from 3 comprehensive personality inventories were used to model these facets as latent factors. We collected both self-report and interview measures of a broad range of psychopathology from a large community sample. Replicating previous findings using a similar approach (Naragon-Gainey & Watson, 2014; Naragon-Gainey, Watson, & Markon, 2009), structural analyses yielded four factors: Positive Emotionality, Sociability, Assertiveness, and Experience Seeking. Scores on these latent dimensions were related to psychopathology in correlational analyses and in two sets of regressions (the first series used the four facets as predictors; the second included composite scores on the other Big Five domains as additional predictors). These results revealed a striking level of specificity. As predicted, Positive Emotionality displayed especially strong negative links to depressive symptoms and diagnoses. Sociability also was negatively related to psychopathology, showing particularly strong associations with indicators of social dysfunction and the negative symptoms of schizotypy (i.e., social anxiety, social aloofness, and restricted affectivity). Assertiveness generally had weak associations at the bivariate level but was negatively related to social anxiety and was positively correlated with some forms of externalizing. Finally, Experience Seeking had substantial positive associations with a broad range of indicators related to externalizing and bipolar disorder; it also displayed negative links to agoraphobia. These differential correlates demonstrate the importance of examining personality-psychopathology relations at the specific facet level. PMID:25751628

  10. Reducing facet nucleation during algorithmic self-assembly.

    PubMed

    Chen, Ho-Lin; Schulman, Rebecca; Goel, Ashish; Winfree, Erik

    2007-09-01

    Algorithmic self-assembly, a generalization of crystal growth, has been proposed as a mechanism for bottom-up fabrication of complex nanostructures and autonomous DNA computation. In principle, growth can be programmed by designing a set of molecular tiles with binding interactions that enforce assembly rules. In practice, however, errors during assembly cause undesired products, drastically reducing yields. Here we provide experimental evidence that assembly can be made more robust to errors by adding redundant tiles that "proofread" assembly. We construct DNA tile sets for two methods, uniform and snaked proofreading. While both tile sets are predicted to reduce errors during growth, the snaked proofreading tile set is also designed to reduce nucleation errors on crystal facets. Using atomic force microscopy to image growth of proofreading tiles on ribbon-like crystals presenting long facets, we show that under the physical conditions we studied the rate of facet nucleation is 4-fold smaller for snaked proofreading tile sets than for uniform proofreading tile sets.

  11. Selective Facet Reactivity During Cation Exchange in Cadmium Sulfide Nanorods

    SciTech Connect

    Sadtler, Bryce; Demchenko, Denis; Zheng, Haimei; Hughes, Steven; Merkle, Maxwell; Dahmen, Ulrich; Wang, Lin-Wang; Alivisatos, A. Paul

    2008-12-18

    The partial transformation of ionic nanocrystals through cation exchange has been used to synthesize nanocrystal heterostructures. We demonstrate that the selectivity for cation exchange to take place at different facets of the nanocrystal plays an important role in determining the resulting morphology of the binary heterostructure. In the case of copper I (Cu+) cation exchange in cadmium sulfide (CdS) nanorods, the reaction starts preferentially at the ends of the nanorods such that copper sulfide (Cu2S) grows inwards from either end. The resulting morphology is very different from the striped pattern obtained in our previous studies of silver I (Ag+) exchange in CdS nanorods where non-selective nucleation of silver sulfide (Ag2S) occurs. From interface formation energies calculated for several models of epitaxialconnections between CdS and Cu2S or Ag2S, we infer the relative stability of each interface during the nucleation and growth of Cu2S or Ag2S within the CdS nanorods. The epitaxial connections of Cu2S to the end facets of CdS nanorods minimize the formation energy, making these interfaces stable throughout the exchange reaction. However, as the two end facets of wurtzite CdS nanorods are crystallographically nonequivalent, asymmetric heterostructures can be produced.

  12. Female students' disordered eating and the big five personality facets.

    PubMed

    MacLaren, Vance V; Best, Lisa A

    2009-08-01

    Female undergraduate students at two Canadian universities (N = 378) completed the NEO PI-R (Costa, P.T. & McCrae, R.R. (1992). NEO PI-R Professional Manual. Lutz, FL: Psychological Assessment Resources) and the Eating Attitudes Test (EAT-26; Garner, D. M., Olmstead, M. P., Bohr, Y. & Garfinkel, P. E. (1982). The Eating Attitudes Test: Psychometric features and clinical correlates. Psychological Medicine, 12, 871-878.). Eating disorder symptomatic (N = 43) and nonsymptomatic (N = 335) women differed on facets of Neuroticism, Extraversion, and Agreeableness. Among symptomatic women, the Oral Control subscale of the EAT-26 was correlated significantly with facets of Neuroticism, Agreeableness and Conscientiousness. Specifically, the Impulsivity facet of Neuroticism was positively correlated with the Bulimia and Food Preoccupation subscale of EAT-26, but negatively correlated with the Oral Control and Dieting subscales. Overall, results suggest that high scores on Neuroticism may be a risk factor for development of disordered eating behavior and that the degree of Impulsiveness may predict the eating disorder subtype to which one is most susceptible.

  13. Facets of loneliness and depression among Chinese children and adolescents.

    PubMed

    Lau, S; Chan, D W; Lau, P S

    1999-12-01

    The authors examined the relation among different facets of loneliness and depression in a sample of 6,356 Chinese children and adolescents from Grades 4-9. Loneliness and depression were closely related among the primary (Grades 4-6) and secondary (Grades 7-9) students, both boys and girls. Although the different facets of loneliness were predictive of the various facets of depression, peer-related loneliness and aloneness were more predictive of depression in both groups than was parent-related loneliness. The students in Grades 5 and 6 scored lower for loneliness but a little higher for depression than did the students in Grade 4. The students in Grades 8 and 9 scored higher than the students in Grade 7 for loneliness and depression. The primary boys scored higher than the primary girls for both loneliness and depression. Among the secondary students, there was no difference between the scores of the boys and those of the girls for loneliness, but the boys scored lower than the girls for depression. PMID:10646306

  14. SHIFT: a distributed runoff model using irregular triangular facets*1

    NASA Astrophysics Data System (ADS)

    Palacios-Vélez, Oscar Luis; Cuevas-Renaud, Baltasar

    1992-06-01

    SHIFT (Sistema HIdrológico de Facetas Triangulares) is a computational system that allows for the: (1) creation, editing and visualization of a watershed Digital Elevation Model (DEM), based on the Triangular Irregular Network (TIN) concepts; (2) input and interpolation of soil, river-bed, and rainfall data; and (3) calculation and routing of runoff in all the facets and reaches. The TIN DEM model is constructed from a set of points, where the slope changes abruptly. Afterwards, the drainage network is automatically identified and an interactive editor allows the addition or deletion of points to eliminate network discontinuities. Rainfall data are interpolated by means of a procedure based on the minimization of the bending energy of a thin plate. In order to calculate and route the runoff, the system determines the routing sequence of river segments and for each one: identifies the facets forming the contributing area; and determines a cascade of overland flow planes. Then, for each element and time interval, the system calculates the infiltration and routes the resultant runoff by a numerical solution of the kinematic wave equations. This information is saved and the user can see the hydrograph for any facet or reach.

  15. Framework Application for Core Edge Transport Simulation (FACETS)

    SciTech Connect

    Krasheninnikov, Sergei; Pigarov, Alexander

    2011-10-15

    The FACETS (Framework Application for Core-Edge Transport Simulations) project of Scientific Discovery through Advanced Computing (SciDAC) Program was aimed at providing a high-fidelity whole-tokamak modeling for the U.S. magnetic fusion energy program and ITER through coupling separate components for each of the core region, edge region, and wall, with realistic plasma particles and power sources and turbulent transport simulation. The project also aimed at developing advanced numerical algorithms, efficient implicit coupling methods, and software tools utilizing the leadership class computing facilities under Advanced Scientific Computing Research (ASCR). The FACETS project was conducted by a multi-discipline, multi-institutional teams, the Lead PI was J.R. Cary (Tech-X Corp.). In the FACETS project, the Applied Plasma Theory Group at the MAE Department of UCSD developed the Wall and Plasma-Surface Interaction (WALLPSI) module, performed its validation against experimental data, and integrated it into the developed framework. WALLPSI is a one-dimensional, coarse grained, reaction/advection/diffusion code applied to each material boundary cell in the common modeling domain for a tokamak. It incorporates an advanced model for plasma particle transport and retention in the solid matter of plasma facing components, simulation of plasma heat power load handling, calculation of erosion/deposition, and simulation of synergistic effects in strong plasma-wall coupling.

  16. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine.

    PubMed

    Meeusen, Romain; Duclos, Martine; Foster, Carl; Fry, Andrew; Gleeson, Michael; Nieman, David; Raglin, John; Rietjens, Gerard; Steinacker, Jürgen; Urhausen, Axel

    2013-01-01

    Successful training not only must involve overload but also must avoid the combination of excessive overload plus inadequate recovery. Athletes can experience short-term performance decrement without severe psychological or lasting other negative symptoms. This functional overreaching will eventually lead to an improvement in performance after recovery. When athletes do not sufficiently respect the balance between training and recovery, nonfunctional overreaching (NFOR) can occur. The distinction between NFOR and overtraining syndrome (OTS) is very difficult and will depend on the clinical outcome and exclusion diagnosis. The athlete will often show the same clinical, hormonal, and other signs and symptoms. A keyword in the recognition of OTS might be "prolonged maladaptation" not only of the athlete but also of several biological, neurochemical, and hormonal regulation mechanisms. It is generally thought that symptoms of OTS, such as fatigue, performance decline, and mood disturbances, are more severe than those of NFOR. However, there is no scientific evidence to either confirm or refute this suggestion. One approach to understanding the etiology of OTS involves the exclusion of organic diseases or infections and factors such as dietary caloric restriction (negative energy balance) and insufficient carbohydrate and/or protein intake, iron deficiency, magnesium deficiency, allergies, and others together with identification of initiating events or triggers. In this article, we provide the recent status of possible markers for the detection of OTS. Currently, several markers (hormones, performance tests, psychological tests, and biochemical and immune markers) are used, but none of them meet all the criteria to make their use generally accepted.

  17. Joint assembly

    NASA Technical Reports Server (NTRS)

    Wilson, Andrew (Inventor); Punnoose, Andrew (Inventor); Strausser, Katherine (Inventor); Parikh, Neil (Inventor)

    2010-01-01

    A joint assembly is provided which includes a drive assembly and a swivel mechanism. The drive assembly features a motor operatively associated with a plurality of drive shafts for driving auxiliary elements, and a plurality of swivel shafts for pivoting the drive assembly. The swivel mechanism engages the swivel shafts and has a fixable element that may be attached to a foundation. The swivel mechanism is adapted to cooperate with the swivel shafts to pivot the drive assembly with at least two degrees of freedom relative to the foundation. The joint assembly allows for all components to remain encased in a tight, compact, and sealed package, making it ideal for space, exploratory, and commercial applications.

  18. Status of Plasma Electron Hose Instability Studies in FACET

    SciTech Connect

    Adli, Erik; England, Robert Joel; Frederico, Joel; Hogan, Mark; Li, Selina Zhao; Litos, Michael Dennis; Nosochkov, Yuri; An, Weiming; Mori, Warren; /UCLA

    2011-12-13

    In the FACET plasma-wakefield acceleration experiment a dense 23 GeV electron beam will interact with lithium and cesium plasmas, leading to plasma ion-channel formation. The interaction between the electron beam and the plasma sheath-electrons may lead to a fast growing electron hose instability. By using optics dispersion knobs to induce a controlled z-x tilt along the beam entering the plasma, we investigate the transverse behavior of the beam in the plasma as function of the tilt. We seek to quantify limits on the instability in order to further explore potential limitations on future plasma wakefield accelerators due to the electron hose instability. The FACET plasma-wakefield experiment at SLAC will study beam driven plasma wakefield acceleration. A dense 23 GeV electron beam will interact with lithium or cesium plasma, leading to plasma ion-channel formation. The interaction between the electron beam and the plasma sheath-electrons drives the electron hose instability, as first studied by Whittum. While Ref. [2] indicates the possibility of a large instability growth rate for typical beam and plasma parameters, other studies including have shown that several physical effects may mitigate the hosing growth rate substantially. So far there has been no quantitative benchmarking of experimentally observed hosing in previous experiments. At FACET we aim to perform such benchmarking by for example inducing a controlled z-x tilt along the beamentering the plasma, and observing the transverse behavior of the beam in the plasma as function. The long-term objective of these studies is to quantify potential limitations on future plasma wakefield accelerators due to the electron hose instability.

  19. Using Facet Clusters to Guide Teacher Professional Development

    NASA Astrophysics Data System (ADS)

    Seeley, Lane; DeWater, L. S.; Vokos, S.; Kraus, P.

    2006-12-01

    The Department of Physics and the School of Education at Seattle Pacific University, together with FACET Innovations, LLC, are beginning the second year of a five-year NSF TPC project, Improving the Effectiveness of Teacher Diagnostic Skills and Tools. We are working in partnership with school districts in Washington State to help teachers make their classrooms into better diagnostic learning environments. In this talk, we describe initial efforts to construct content-rich professional development courses for teachers, which are infused with diagnostic assessment that target the fine structure of student ideas in specific topical areas. * Supported in part by NSF grant #ESI-0455796, The Boeing Corporation, and the SPU Science Initiative.

  20. An Enhanced Facet Determination Scheme in 3D

    NASA Astrophysics Data System (ADS)

    Reivinen, M.; Salonen, E.-M.; Todoshchenko, I.; Vaskelainen, V. P.

    2016-07-01

    An enhanced scheme for the determination of equilibrium crystal shapes is introduced. The emphasis of the present study is put on the proper detection of the facets appearing on the crystal surface. The original formulation presented in [1] employs the principle of the virtual work, and the enhanced scheme additionally makes use of a penalty formulation approach. The derivation of the penalty terms is discussed in detail. Finally, the corresponding discrete method is applied to a certain problematic example case presented in [1] resulting now in the correct crystal shape.

  1. Effects of unilateral facet fixation and facetectomy on muscle spindle responsiveness during simulated spinal manipulation in an animal model

    PubMed Central

    Reed, William R.; Long, Cynthia R.; Pickar, Joel G.

    2013-01-01

    Objectives Manual therapy practitioners commonly assess lumbar intervertebral mobility before deciding treatment regimens. Changes in mechanoreceptor activity during the manipulative thrust are theorized to be an underlying mechanism of spinal manipulation (SM) efficacy. The objective of this study was to determine if facet fixation or facetectomy at a single lumbar level alters muscle spindle activity during 5 SM thrust durations in an animal model. Methods Spinal stiffness was determined using the slope of a force-displacement curve. Changes in the mean instantaneous frequency of spindle discharge were measured during simulated SM of the L6 vertebra in the same 20 afferents for laminectomy-only, 19 laminectomy & facet screw conditions; only 5 also had data for the laminectomy & facetectomy condition. Neural responses were compared across conditions and five thrust durations (≤ 250ms) using linear mixed models. Results Significant decreases in afferent activity between the laminectomy-only and laminectomy & facet screw conditions were seen during 75ms (P<.001), 100ms (P=.04) and 150ms (P=.02) SM thrust durations. Significant increases in spindle activity between the laminectomy-only and laminectomy & facetectomy conditions were seen during the 75ms (P<.001) and 100ms (P<.001) thrust durations. Conclusion Intervertebral mobility at a single segmental level alters paraspinal sensory response during clinically relevant high velocity low amplitude SM thrust durations (≤150ms). The relationship between intervertebral joint mobility and alterations of primary afferent activity during and following various manual therapy interventions may be used to help to identify patient subpopulations who respond to different types of manual therapy and better inform practitioners (eg, chiropractic, osteopathic) delivering the therapeutic intervention. PMID:24161386

  2. FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing.

    PubMed

    Shen, Ronglai; Seshan, Venkatraman E

    2016-09-19

    Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions, copy-neutral loss-of-heterozygosity (LOH), allele-specific gains/amplifications. In addition, as targeted gene panels are increasingly used in clinical sequencing studies for the detection of 'actionable' mutations and copy number alterations to guide treatment decisions, accurate, tumor purity-, ploidy- and clonal heterogeneity-adjusted integer copy number calls are greatly needed to more reliably interpret NGS-based cancer gene copy number data in the context of clinical sequencing. We developed FACETS, an ASCN tool and open-source software with a broad application to whole genome, whole-exome, as well as targeted panel sequencing platforms. It is a fully integrated stand-alone pipeline that includes sequencing BAM file post-processing, joint segmentation of total- and allele-specific read counts, and integer copy number calls corrected for tumor purity, ploidy and clonal heterogeneity, with comprehensive output and integrated visualization. We demonstrate the application of FACETS using The Cancer Genome Atlas (TCGA) whole-exome sequencing of lung adenocarcinoma samples. We also demonstrate its application to a clinical sequencing platform based on a targeted gene panel.

  3. FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

    PubMed Central

    Shen, Ronglai; Seshan, Venkatraman E.

    2016-01-01

    Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions, copy-neutral loss-of-heterozygosity (LOH), allele-specific gains/amplifications. In addition, as targeted gene panels are increasingly used in clinical sequencing studies for the detection of ‘actionable’ mutations and copy number alterations to guide treatment decisions, accurate, tumor purity-, ploidy- and clonal heterogeneity-adjusted integer copy number calls are greatly needed to more reliably interpret NGS-based cancer gene copy number data in the context of clinical sequencing. We developed FACETS, an ASCN tool and open-source software with a broad application to whole genome, whole-exome, as well as targeted panel sequencing platforms. It is a fully integrated stand-alone pipeline that includes sequencing BAM file post-processing, joint segmentation of total- and allele-specific read counts, and integer copy number calls corrected for tumor purity, ploidy and clonal heterogeneity, with comprehensive output and integrated visualization. We demonstrate the application of FACETS using The Cancer Genome Atlas (TCGA) whole-exome sequencing of lung adenocarcinoma samples. We also demonstrate its application to a clinical sequencing platform based on a targeted gene panel. PMID:27270079

  4. FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing.

    PubMed

    Shen, Ronglai; Seshan, Venkatraman E

    2016-09-19

    Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions, copy-neutral loss-of-heterozygosity (LOH), allele-specific gains/amplifications. In addition, as targeted gene panels are increasingly used in clinical sequencing studies for the detection of 'actionable' mutations and copy number alterations to guide treatment decisions, accurate, tumor purity-, ploidy- and clonal heterogeneity-adjusted integer copy number calls are greatly needed to more reliably interpret NGS-based cancer gene copy number data in the context of clinical sequencing. We developed FACETS, an ASCN tool and open-source software with a broad application to whole genome, whole-exome, as well as targeted panel sequencing platforms. It is a fully integrated stand-alone pipeline that includes sequencing BAM file post-processing, joint segmentation of total- and allele-specific read counts, and integer copy number calls corrected for tumor purity, ploidy and clonal heterogeneity, with comprehensive output and integrated visualization. We demonstrate the application of FACETS using The Cancer Genome Atlas (TCGA) whole-exome sequencing of lung adenocarcinoma samples. We also demonstrate its application to a clinical sequencing platform based on a targeted gene panel. PMID:27270079

  5. Singular orientations and faceted motion of dislocations in body-centered cubic crystals

    PubMed Central

    Kang, Keonwook; Bulatov, Vasily V.; Cai, Wei

    2012-01-01

    Dislocation mobility is a fundamental material property that controls strength and ductility of crystals. An important measure of dislocation mobility is its Peierls stress, i.e., the minimal stress required to move a dislocation at zero temperature. Here we report that, in the body-centered cubic metal tantalum, the Peierls stress as a function of dislocation orientation exhibits fine structure with several singular orientations of high Peierls stress—stress spikes—surrounded by vicinal plateau regions. While the classical Peierls-Nabarro model captures the high Peierls stress of singular orientations, an extension that allows dislocations to bend is necessary to account for the plateau regions. Our results clarify the notion of dislocation kinks as meaningful only for orientations within the plateau regions vicinal to the Peierls stress spikes. These observations lead us to propose a Read-Shockley type classification of dislocation orientations into three distinct classes—special, vicinal, and general—with respect to their Peierls stress and motion mechanisms. We predict that dislocation loops expanding under stress at sufficiently low temperatures, should develop well defined facets corresponding to two special orientations of highest Peierls stress, the screw and the M111 orientations, both moving by kink mechanism. We propose that both the screw and the M111 dislocations are jointly responsible for the yield behavior of BCC metals at low temperatures. PMID:22949701

  6. Intensity Effects of the FACET Beam in the SLAC Linac

    SciTech Connect

    Decker, F.-J.; Lipkowitz, N.; Sheppard, J.; White, G.R.; Wienands, U.; Woodley, M.; Yocky, G.; /SLAC

    2012-07-03

    The beam for FACET (Facility for Advanced aCcelerator Experimental Tests) at SLAC requires an energy-time correlation ('chirp') along the linac, so it can be compressed in two chicanes, one at the midpoint in sector 10 and one W-shaped chicane just before the FACET experimental area. The induced correlation has the opposite sign to the typical used for BNS damping, and therefore any orbit variations away from the center kick the tail of the beam more than the head, causing a shear in the beam and emittance growth. Any dispersion created along the linac has similar effects due to the high (>1.2% rms) energy spread necessary for compression. The initial huge emittances could be reduced by a factor of 10, but were still bigger than expected by a factor of 2-3. Normalized emittance of 3 {micro}m-rad in Sector 2 blew up to 150 {micro}m-rad in Sector 11 but could be reduced to about 6-12 {micro}m-rad, for the vertical plane although the results were not very stable. Investigating possible root causes for this, we found locations where up to 10 mm dispersion was created along the linac, which were finally verified with strong steering and up to 7 mm settling of the linac accelerator at these locations.

  7. Zernike-like systems in polygons and polygonal facets.

    PubMed

    Ferreira, Chelo; López, José L; Navarro, Rafael; Sinusía, Ester Pérez

    2015-07-20

    Zernike polynomials are commonly used to represent the wavefront phase on circular optical apertures, since they form a complete and orthonormal basis on the unit disk. In [Opt. Lett.32, 74 (2007)10.1364/OL.32.000074OPLEDP0146-9592] we introduced a new Zernike basis for elliptic and annular optical apertures based on an appropriate diffeomorphism between the unit disk and the ellipse and the annulus. Here, we present a generalization of this Zernike basis for a variety of important optical apertures, paying special attention to polygons and the polygonal facets present in segmented mirror telescopes. On the contrary to ad hoc solutions, most of them based on the Gram-Smith orthonormalization method, here we consider a piecewise diffeomorphism that transforms the unit disk into the polygon under consideration. We use this mapping to define a Zernike-like orthonormal system over the polygon. We also consider ensembles of polygonal facets that are essential in the design of segmented mirror telescopes. This generalization, based on in-plane warping of the basis functions, provides a unique solution, and what is more important, it guarantees a reasonable level of invariance of the mathematical properties and the physical meaning of the initial basis functions. Both the general form and the explicit expressions for a typical example of telescope optical aperture are provided. PMID:26367845

  8. Facility for Advanced Accelerator Experimental Tests (FACET) at SLAC and its Radiological Considerations

    SciTech Connect

    Mao, X.S.; Leitner, M.Santana; Vollaire, J.

    2011-08-22

    Facility for Advanced Accelerator Experimental Tests (FACET) in SLAC will be used to study plasma wakefield acceleration. FLUKA Monte Carlo code was used to design a maze wall to separate FACET project and LCLS project to allow persons working in FACET side during LCLS operation. Also FLUKA Monte Carlo code was used to design the shielding for FACET dump to get optimum design for shielding both prompt and residual doses, as well as reducing environmental impact. FACET will be an experimental facility that provides short, intense pulses of electrons and positrons to excite plasma wakefields and study a variety of critical issues associated with plasma wakefield acceleration [1]. This paper describes the FACET beam parameters, the lay-out and its radiological issues.

  9. Temperature-dependent side-facets of GaAs nanopillars

    NASA Astrophysics Data System (ADS)

    Soo, Mun Teng; Zheng, Kun; Gao, Qiang; Tan, Hark Hoe; Jagadish, Chennupati; Zou, Jin

    2016-09-01

    In this study, the effect of growth temperature on the structural properties of Au-catalysed epitaxial GaAs semiconductor nanopillars grown by metal-organic chemical vapour deposition is investigated by electron microscopy. It has been found that the growth temperature plays a significant role on the evolution of side-facets of zinc-blende structured GaAs nanopillars. At a growth temperature of 550 °C, six \\{112\\} side-facets are formed; whereas at a higher growth temperature of 600 °C, six \\{110\\} side-facets are observed. It is believed that the formation of \\{112\\} side-facets is a kinetically dominated process while the formation of \\{110\\} side-facets is a thermodynamical process. Besides, the diffusion-induced nanopillar foundations present the same \\{112\\} edge side-facets regardless of the growth temperature.

  10. Comparing Linkage Designs Based on Land Facets to Linkage Designs Based on Focal Species

    PubMed Central

    Brost, Brian M.; Beier, Paul

    2012-01-01

    Least-cost modeling for focal species is the most widely used method for designing conservation corridors and linkages. However, these designs depend on today's land covers, which will be altered by climate change. We recently proposed an alternative approach based on land facets (recurring landscape units of relatively uniform topography and soils). The rationale is that corridors with high continuity of individual land facets will facilitate movement of species associated with each facet today and in the future. Conservation practitioners might like to know whether a linkage design based on land facets is likely to provide continuity of modeled breeding habitat for species needing connectivity today, and whether a linkage for focal species provides continuity and interspersion of land facets. To address these questions, we compared linkages designed for focal species and land facets in three landscapes in Arizona, USA. We used two variables to measure linkage utility, namely distances between patches of modeled breeding habitat for 5–16 focal species in each linkage, and resistance profiles for focal species and land facets between patches connected by the linkage. Compared to focal species designs, linkage designs based on land facets provided as much or more modeled habitat connectivity for 25 of 28 species-landscape combinations, failing only for the three species with the most narrowly distributed habitat. Compared to land facets designs, focal species linkages provided lower connectivity for about half the land facets in two landscapes. In areas where a focal species approach to linkage design is not possible, our results suggest that conservation practitioners may be able to implement a land facets approach with some confidence that the linkage design would serve most potential focal species. In areas where focal species designs are possible, we recommend using the land facet approach to complement, rather than replace, focal species approaches. PMID

  11. A model for the geomorphic development of normal-fault facets

    NASA Astrophysics Data System (ADS)

    Tucker, G. E.; Hobley, D. E. J.; McCoy, S. W.

    2014-12-01

    Triangular facets are among the most striking landforms associated with normal faulting. The genesis of facets is of great interest both for the information facets contain about tectonic motion, and because the progressive emergence of facets makes them potential recorders of both geomorphic and tectonic history. In this report, we present observations of triangular facets in the western United States and in the Italian Central Apennines. Facets in these regions typically form quasi-planar surfaces that are aligned in series along and above the trace of an active fault. Some facet surfaces consist mainly of exposed bedrock, with a thin and highly discontinuous cover of loose regolith. Other facets are mantled by a several-decimeter-thick regolith cover. Over the course of its morphologic development, a facet slope segment may evolve from a steep (~60 degree) bedrock fault scarp, well above the angle of repose for soil, to a gentler (~20-40 degree) slope that can potentially sustain a coherent regolith cover. This evolutionary trajectory across the angle of repose renders nonlinear diffusion theory inapplicable. To formulate an alternative process-based theory for facet evolution, we use a particle-based approach that acknowledges the possibility for both short- and long-range sediment-grain motions, depending on the topography. The processes of rock weathering, grain entrainment, and grain motion are represented as stochastic state-pair transitions with specified transition rates. The model predicts that facet behavior can range smoothly along the spectrum from a weathering-limited mode to a transport-limited mode, depending on the ratio of fault-slip rate to bare-bedrock regolith production rate. The model also implies that facets formed along a fault with pinned tips should show systematic variation in slope angle that correlates with along-fault position and slip rate. Preliminary observations from central Italy and the eastern Basin and Range are consistent

  12. FACET: an object-oriented software framework for modeling complex social behavior patterns

    SciTech Connect

    Dolph, J. E.; Christiansen, J. H.; Sydelko, P. J.

    2000-06-30

    The Framework for Addressing Cooperative Extended Transactions (FACET) is a flexible, object-oriented architecture for implementing models of dynamic behavior of multiple individuals, or agents, in a simulation. These agents can be human (individuals or organizations) or animal and may exhibit any type of organized social behavior that can be logically articulated. FACET was developed by Argonne National Laboratory's (ANL) Decision and Information Sciences Division (DIS) out of the need to integrate societal processes into natural system simulations. The FACET architecture includes generic software components that provide the agents with various mechanisms for interaction, such as step sequencing and logic, resource management, conflict resolution, and preemptive event handling. FACET components provide a rich environment within which patterns of behavior can be captured in a highly expressive manner. Interactions among agents in FACET are represented by Course of Action (COA) object-based models. Each COA contains a directed graph of individual actions, which represents any known pattern of social behavior. The agents' behavior in a FACET COA, in turn, influences the natural landscape objects in a simulation (i.e., vegetation, soil, and habitat) by updating their states. The modular design of the FACET architecture provides the flexibility to create multiple and varied simulation scenarios by changing social behavior patterns, without disrupting the natural process models. This paper describes the FACET architecture and presents several examples of FACET models that have been developed to assess the effects of anthropogenic influences on the dynamics of the natural environment.

  13. Plasmas, Dielectrics and the Ultrafast: First Science and Operational Experience at FACET

    SciTech Connect

    Clarke, C.I.; Adli, E.; Corde, S.; Decker, F.J.; England, R.J.; Erickson, R.; Fisher, A.; Gessner, S.; Hast, C.; Hogan, M.J.; Li, S.Z.; Lipkowitz, N.; Litos, M.; Nosochkov, Y.; Seeman, J.; Sheppard, J.C.; Tudosa, I.; White, G.; Wienands, U.; Woodley, M.; Wu, Z.; /SLAC /UCLA

    2012-09-14

    FACET (Facility for Advanced Accelerator and Experimental Tests) is an accelerator R&D test facility that has been recently constructed at SLAC National Accelerator Laboratory. The facility provides 20 GeV, 3 nC electron beams, short (20 {micro}m) bunches and small (20 {micro}m wide) spot sizes, producing uniquely high power beams. FACET supports studies from many fields but in particular those of Plasma Wakefield Acceleration and Dielectric Wakefield Acceleration. FACET is also a source of THz radiation for material studies. We present the FACET design, initial operating experience and first science from the facility.

  14. Facets formation mechanism of GaN hexagonal pyramids on dot-patterns via selective MOVPE

    SciTech Connect

    Hiramatsu, Kazumasa; Kitamura, Shota; Sawaki, Nobuhiko

    1996-11-01

    Three-dimensional GaN pyramids have been successfully obtained on dot-patterned GaN(0001)/sapphire substrates by using the selective MOVPE technique. The dot-pattern is a hexagon arranged with a 5{micro}m width and a 10{micro}m spacing. The GaN structure comprises a hexagonal pyramid covered with six {l_brace}1{bar 1}01{r_brace} pyramidal facets on the side or a frustum of a hexagonal pyramid having a (0001) facet on the top. The facet formation mechanism has been investigated by observing the facet structure with the growth time. The {l_brace}1{bar 1}01{r_brace} facets are very stable during the growth. The (0001) facet growth is dominant at the initial growth but almost stops at a certain growth time and then the facet structure is maintained. The appearance of the self-limited (0001) facet is attributed to the balance of flux between incoming Ga atoms from the vapor phase to the (0001) surface and outgoing Ga atoms from the (0001) surface to the {l_brace}1{bar 1}01{r_brace} surface via migration. The longer the diffusion length of the Ga atoms on the (0001) surface is, the more the surface migration is enhanced, resulting in the appearance of the wider (0001) facet on the top.

  15. Nonlinear elastic model for faceting of vesicles with soft grain boundaries

    NASA Astrophysics Data System (ADS)

    Sknepnek, Rastko; Olvera de la Cruz, Monica

    2012-05-01

    We use an elastic model to explore faceting of solid-wall vesicles with elastic heterogeneities. We show that faceting occurs in regions where the vesicle wall is softer, such as areas of reduced wall thicknesses or concentrated in crystalline defects. The elastic heterogeneities are modeled as a second component with reduced elastic parameters. Using simulated annealing Monte Carlo simulations we obtain the vesicle shape by optimizing the distributions of facets and boundaries. Our model allows us to reduce the effects of the residual stress generated by crystalline defects, and reveals a robust faceting mechanism into polyhedra other than the icosahedron.

  16. Traumatic cervical cord transection without facet dislocations--a proposal of combined hyperflexion-hyperextension mechanism: a case report.

    PubMed

    Cha, Yoo-Hyun; Cho, Tai-Hyoung; Suh, Jung-Keun

    2010-08-01

    A patient is presented with a cervical spinal cord transection which occurred after a motor vehicle accident in which the air bag deployed and the seat belt was not in use. The patient had complete quadriplegia below the C5 level and his imaging study showed cervical cord transection at the level of the C5/6 disc space with C5, C6 vertebral bodies and laminar fractures. He underwent a C5 laminectomy and a C4-7 posterior fusion with lateral mass screw fixation. Previous reports have described central cord syndromes occurring in hyperextension injuries, but in adults, acute spinal cord transections have only developed after fracture-dislocations of the spine. A case involving a post-traumatic spinal cord transection without any evidence of radiologic facet dislocations is reported. Also, we propose a combined hyperflexion-hyperextension mechanism to explain this type of injury.

  17. Medical management of failed back surgery syndrome in Europe: evaluation modalities and treatment proposals.

    PubMed

    Durand, G; Girodon, J; Debiais, F

    2015-03-01

    Failed back surgery syndrome (FBSS) is defined as persistent pain more than 3 months after any form of spinal surgery. Due to its multifactorial origin, FBSS is often difficult to treat. In this context of failed back surgery, a very thorough assessment must be conducted concerning the site and characteristics of the pain (nociceptive or neuropathic), its mode of onset (presence or absence of pain-free intervals), and its impact on the patient's work and social life. Physical examination must exclude a non-spinal cause for the pain. MRI is the imaging modality of choice in this disease, but is often difficult to interpret, as MR signals are modified for 6 months after the operation. Scar tissue, which can be distinguished from recurrent disc hernia by its gadolinium enhancement, is present even in asymptomatic patients. After having eliminated infection and sacroiliac or posterior facet joint disease, the main aetiologies investigated are foraminal stenosis, degenerative disc disease, recurrent disc hernia, and non-union of spinal fusion; sometimes patients only experience persistent neuropathic pain. The treatment of failed back surgery syndrome with a predominant neuropathic component is based on the use of analgesics, especially antiepileptics, antidepressants or transcutaneous electrical stimulation. Epidural spinal infiltration should be considered as second-line treatment in view of the risk of serious neurological complications. Management must be based on a global, multidisciplinary approach with identification of any cognitive or behavioural disorders in combination with an appropriate functional rehabilitation programme. PMID:25676909

  18. Aerodynamics Investigation of Faceted Airfoils at Low Reynolds Number

    NASA Astrophysics Data System (ADS)

    Napolillo, Zachary G.

    The desire and demand to fly farther and faster has progressively integrated the concept of optimization with airfoil design, resulting in increasingly complex numerical tools pursuing efficiency often at diminishing returns; while the costs and difficulty associated with fabrication increases with design complexity. Such efficiencies may often be necessary due to the power density limitations of certain aircraft such as small unmanned aerial vehicles (UAVs) and micro air vehicles (MAVs). This research, however, focuses on reducing the complexity of airfoils for applications where aerodynamic performance is less important than the efficiency of manufacturing; in this case a Hybrid Projectile. By employing faceted sections to approximate traditional contoured wing sections it may be possible to expedite manufacturing and reduce costs. We applied this method to the development of a low Reynolds number, disposable Hybrid Projectile requiring a 4.5:1 glide ratio, resulting in a series of airfoils which are geometric approximations to highly contoured cross-sections called ShopFoils. This series of airfoils both numerically and experimentally perform within a 10% margin of the SD6060 airfoil at low Re. Additionally, flow visualization has been conducted to qualitatively determine what mechanisms, if any, are responsible for the similarity in performance between the faceted ShopFoil sections and the SD6060. The data obtained by these experiments did not conclusively reveal how the faceted surfaces may influence low Re flow but did indicate that the ShopFoil s did not maintain flow attachment at higher angles of attack than the SD6060. Two reasons are provided for the unexpected performance of the ShopFoil: one is related to downwash effects, which are suspected of placing the outer portion of the span at an effective angle of attack where the ShopFoils outperform the SD6060; the other is the influence of the tip vortex on separation near the wing tips, which possibly

  19. Auriculotemporal Syndrome (Frey Syndrome).

    PubMed

    Motz, Kevin M; Kim, Young J

    2016-04-01

    Frey syndrome is a common sequela of parotidectomy, and although it is not frequently manifested clinically, it can cause significant morbidity for those affected. Frey syndrome results from synkinetic autonomic reinnervation by transected postganglionic parasympathetic nerve fiber within the parotid gland to the overlying sweat glands of the skin. Many surgical techniques have been proposed to prevent the development of Frey syndrome. For those who develop clinical symptoms of Frey syndrome, objective testing can be performed with a Minor starch-iodine test. Some of the current methods to prevent and treat symptomatic Frey syndrome are reviewed. PMID:26902982

  20. Voyager: Exploratory Analysis via Faceted Browsing of Visualization Recommendations.

    PubMed

    Wongsuphasawat, Kanit; Moritz, Dominik; Anand, Anushka; Mackinlay, Jock; Howe, Bill; Heer, Jeffrey

    2016-01-01

    General visualization tools typically require manual specification of views: analysts must select data variables and then choose which transformations and visual encodings to apply. These decisions often involve both domain and visualization design expertise, and may impose a tedious specification process that impedes exploration. In this paper, we seek to complement manual chart construction with interactive navigation of a gallery of automatically-generated visualizations. We contribute Voyager, a mixed-initiative system that supports faceted browsing of recommended charts chosen according to statistical and perceptual measures. We describe Voyager's architecture, motivating design principles, and methods for generating and interacting with visualization recommendations. In a study comparing Voyager to a manual visualization specification tool, we find that Voyager facilitates exploration of previously unseen data and leads to increased data variable coverage. We then distill design implications for visualization tools, in particular the need to balance rapid exploration and targeted question-answering.

  1. Giant photoluminescence emission in crystalline faceted Si grains

    PubMed Central

    Faraci, Giuseppe; Pennisi, Agata R.; Alberti, Alessandra; Ruggeri, Rosa; Mannino, Giovanni

    2013-01-01

    Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting of crystalline faceted Si grains (fg-Si), a hundred nanometer in size, assembled in a porous and columnar configuration, without any post processing. A laser beam with wavelength 632.8 nm locally produce such a high temperature, determined on layers of a given thickness by Raman spectra, to induce giant PL radiation emission. The optical gain reaches the highest value ever, 0.14 cm/W, representing an increase of 3 orders of magnitude with respect to comparable data recently obtained in nanocrystals. Giant emission has been obtained from fg-Si deposited either on glass or on flexible, low cost, polymeric substrate opening the possibility to fabricate new devices. PMID:24056300

  2. Micro-Facet Scattering Model for Pulse Polarization Ranging

    NASA Astrophysics Data System (ADS)

    Stryjewski, J.; Roggemann, M.; Tyler, D.; Hand, D.

    Determining the shape, material and orientation of nano-sats (satellites too small to image from the ground) requires new sensing approaches. Pulse Polarization Ranging (PPR) is one such approach that uses the polarization and shape characteristics of laser pulses reflected from satellites to determine satellite shape, orientation and material. We use an innovative approach to relate PPR measurements to actual satellite characteristics (shape, material and orientation), requiring that we have an accurate physical and dynamical model of the satellite. In particular, to determine the polarization characteristics (depolarization, birefringence, diattenuation) of the reflected pulses we need an accurate model of light scattering from real (complex) surfaces. To do this, we have extended the micro-facet model of Ashikhmin et al. to include retro-reflection and multiple scattering effects. In this presentation, we describe the scattering model and its efficient implementation using graphical processing units (GPUs).

  3. "Decoding" Angiogenesis: New Facets Controlling Endothelial Cell Behavior.

    PubMed

    Sewduth, Raj; Santoro, Massimo M

    2016-01-01

    Angiogenesis, the formation of new blood vessels, is a unique and crucial biological process occurring during both development and adulthood. A better understanding of the mechanisms that regulates such process is mandatory to intervene in pathophysiological conditions. Here we highlight some recent argument on new players that are critical in endothelial cells, by summarizing novel discoveries that regulate notorious vascular pathways such as Vascular Endothelial Growth Factor (VEGF), Notch and Planar Cell Polarity (PCP), and by discussing more recent findings that put metabolism, redox signaling and hemodynamic forces as novel unforeseen facets in angiogenesis. These new aspects, that critically regulate angiogenesis and vascular homeostasis in health and diseased, represent unforeseen new ground to develop anti-angiogenic therapies. PMID:27493632

  4. “Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior

    PubMed Central

    Sewduth, Raj; Santoro, Massimo M.

    2016-01-01

    Angiogenesis, the formation of new blood vessels, is a unique and crucial biological process occurring during both development and adulthood. A better understanding of the mechanisms that regulates such process is mandatory to intervene in pathophysiological conditions. Here we highlight some recent argument on new players that are critical in endothelial cells, by summarizing novel discoveries that regulate notorious vascular pathways such as Vascular Endothelial Growth Factor (VEGF), Notch and Planar Cell Polarity (PCP), and by discussing more recent findings that put metabolism, redox signaling and hemodynamic forces as novel unforeseen facets in angiogenesis. These new aspects, that critically regulate angiogenesis and vascular homeostasis in health and diseased, represent unforeseen new ground to develop anti-angiogenic therapies. PMID:27493632

  5. Do different facets of impulsivity predict different types of aggression?

    PubMed

    Derefinko, Karen; DeWall, C Nathan; Metze, Amanda V; Walsh, Erin C; Lynam, Donald R

    2011-01-01

    This study examined the relations between impulsivity-related traits (as assessed by the UPPS-P Impulsive Behavior Scale) and aggressive behaviors. Results indicated that UPPS-P Lack of Premeditation and Sensation Seeking were important in predicting general violence. In contrast, UPPS-P Urgency was most useful in predicting intimate partner violence. To further explore relations between intimate partner violence and Urgency, a measure of autonomic response to pleasant and aversive stimuli and facets of Neuroticism from the NEO PI-R were used as control variables. Autonomic responsivity was correlated with intimate partner violence at the zero-order level, and predicted significant variance in intimate partner violence in regression equations. However, UPPS-P Urgency was able to account for unique variance in intimate partner violence, above and beyond measures of Neuroticism and arousal. Implications regarding the use of a multifaceted conceptualization of impulsivity in the prediction of different types of violent behavior are discussed. PMID:21259270

  6. Tourette syndrome

    MedlinePlus

    Gilles de la Tourette syndrome; Tic disorders - Tourette syndrome ... Tourette syndrome is named for Georges Gilles de la Tourette, who first described this disorder in 1885. The disorder is likely passed down through families. The syndrome may be linked to ...

  7. Joint x-ray

    MedlinePlus

    X-ray - joint; Arthrography; Arthrogram ... x-ray technologist will help you position the joint to be x-rayed on the table. Once in place, pictures are taken. The joint may be moved into other positions for more ...

  8. Joint Instability and Osteoarthritis

    PubMed Central

    Blalock, Darryl; Miller, Andrew; Tilley, Michael; Wang, Jinxi

    2015-01-01

    Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA. PMID:25741184

  9. Flexion contractures associated with a malignant neoplasm: 'A paraneoplastic syndrome?'.

    PubMed

    Eekhoff, E M; van der Lubbe, P A; Breedveld, F C

    1998-01-01

    A 71-year-old man developed polyarthritis and, subsequently, severe flexion contractures of multiple joints, particularly the joints of the hands. Eighteen months after developing this disease a parailiacal lymph node metastasis of an unknown primary cancer was found. We suggest that this patient's history, dominated by contractures that resembled the 'palmar fasciitis and polyarthritis syndrome', should be considered as a paraneoplastic syndrome.

  10. Nitrogen-induced reconstruction and faceting of Re(112{sup ¯}1)

    SciTech Connect

    Wang, Hao; Chen, Wenhua; Bartynski, Robert A.; Kaghazchi, Payam; Jacob, Timo

    2014-01-14

    The surface morphology of Re(112{sup ¯}1), tailored on the nanometer scale by kinetic control of nitrogen, has been investigated using low energy electron diffraction, scanning tunneling microscopy, Auger electron spectroscopy, and density functional theory (DFT) in combination with the ab initio atomistic thermodynamics approach. Experiments show that when exposing to NH{sub 3} (>0.5 L) at 300 K followed by annealing in ultra-high vacuum at 700 K or 900 K, the initially planar Re(112{sup ¯}1) surface becomes (2 × 1) reconstructed or partially faceted, respectively. Upon annealing in 100 L NH{sub 3} at 900 K, Re(112{sup ¯}1) becomes fully faceted and covered by N. The fully faceted surface consists of two-sided ridges formed by (134{sup ¯}2) and (314{sup ¯}2) facets. The (2 × 1) reconstruction may serve as a precursor state for faceting of Re(112{sup ¯}1). The DFT calculations provide an atomistic understanding of facet formation in terms of binding sites and energies of N on Re surfaces of the substrate and facets as well as the corresponding surface phase diagram. The N-covered faceted Re(112{sup ¯}1) surfaces are promising nanoscale model catalysts and nanotemplates. Our findings should be of importance for the design and development of Re-based heterogeneous catalysts operating under nitrogen-rich conditions.

  11. Contacting ZnO Individual Crystal Facets by Direct Write Lithography.

    PubMed

    Petkov, Nikolay; Volk, János; Erdélyi, Róbert; Lukács, István Endre; Nagata, Takahiro; Sturm, Chris; Grundmann, M

    2016-09-14

    Many advanced electronic devices take advantage of properties developed at the surface facets of grown crystals with submicrometer dimensions. Electrical contacts to individual crystal facets can make possible the investigations of facet-dependent properties such as piezoelectricity in ZnO or III-nitride crystals having noncentrosymmetric structure. However, a lithography-based method for developing contacts to individual crystal facets with submicrometer size has not yet been demonstrated. In this report we study the use of electron beam-induced deposition (EBID), a direct write lithography method, for contacting individual facets of ZnO pillars within an electron microscope. Correlating structural and in situ deposition and electrical data, we examine proximity effects during the EBID and evaluate the process against obtaining electrically insulated contact lines on neighboring and diametrically opposite ZnO facets. Parameters such as incident beam energy geometry and size of the facets were investigated with the view of minimizing unwanted proximity broadening effects. Additionally, we show that the EBID direct write method has the required flexibility, resolution, and minimized proximity deposition for creating prototype devices. The devices were used to observe facet-dependent effects induced by mechanical stress on single ZnO pillar structures. PMID:27533719

  12. Novel photocatalytic antibacterial activity of TiO2 microspheres exposing 100% reactive {111} facets.

    PubMed

    Sun, Liang; Qin, Ying; Cao, Qingqing; Hu, Bingqing; Huang, Zhiwei; Ye, Ling; Tang, Xingfu

    2011-12-21

    TiO(2) microspheres constructed by well-crystallized faceted nanorods with high aspect ratios expose 100% photocatalytic reactive {111} facets on the spherical surface. The microspheres demonstrated excellent photocatalytic antibacterial activity towards Staphylococcus aureus due to effective suppression of photoinduced electron-hole pair recombination and active TiO(2)@˙OH core-shell structure. PMID:22051605

  13. A Facet Theory Model for Integrating Contextual and Personal Experiences of International Students

    ERIC Educational Resources Information Center

    Hackett, Paul M. W.

    2014-01-01

    The purpose of this article is to use a facet theory research approach to provide a clear, coherent, and integrated model of international students' experiences based upon the findings of psychological research into students when studying abroad. In research that employs a facet theory approach events are classified in terms of their constituent…

  14. Spacesuit mobility knee joints

    NASA Technical Reports Server (NTRS)

    Vykukal, H. C. (Inventor)

    1979-01-01

    Pressure suit mobility joints are for use in interconnecting adjacent segments of an hermetically sealed spacesuit in which low torques, low leakage and a high degree of reliability are required. Each of the joints is a special purpose joint characterized by substantially constant volume and low torque characteristics and includes linkages which restrain the joint from longitudinal distension and includes a flexible, substantially impermeable diaphragm of tubular configuration spanning the distance between pivotally supported annuli. The diaphragms of selected joints include rolling convolutions for balancing the joints, while various joints include wedge-shaped sections which enhance the range of motion for the joints.

  15. Spacesuit mobility joints

    NASA Technical Reports Server (NTRS)

    Vykukal, H. C. (Inventor)

    1978-01-01

    Joints for use in interconnecting adjacent segments of an hermetically sealed spacesuit which have low torques, low leakage and a high degree of reliability are described. Each of the joints is a special purpose joint characterized by substantially constant volume and low torque characteristics. Linkages which restrain the joint from longitudinal distension and a flexible, substantially impermeable diaphragm of tubular configuration spanning the distance between pivotally supported annuli are featured. The diaphragms of selected joints include rolling convolutions for balancing the joints, while various joints include wedge-shaped sections which enhance the range of motion for the joints.

  16. Evolution of (001) and (111) facets for selective epitaxial growth inside submicron trenches

    SciTech Connect

    Jiang, S. Heyns, M.; Merckling, C.; Guo, W.; Waldron, N.; Caymax, M.; Vandervorst, W.; Seefeldt, M.

    2014-01-14

    The evolution of (001) and (111) facets for the epitaxial growth inside submicron trenches is systematically studied in this report. The analysis with the method of “Lagrange multiplier” indicates the equilibrium crystal shape. In the case of non-equilibrium without external fluxes, we employed the “weighted mean curvature” method to mathematically model the inter-facet migration rate for two extreme kinetic cases: “surface diffusion limited” and “surface attachment/detachment limited.” Coupled with external supply of atoms, the self-limited behavior of facet size is theoretically predicted. Moreover, we find that the self-limited stable facet size in trenches of different widths has a specific relationship determined by the surface energy ratio, kinetic rate ratio, and isolated growth rate difference. The two limited cases could be discriminated according to the mathematical fitting of one exponent in this relationship based on the stable facet size in trenches of different widths.

  17. Quantum cascade lasers with a tilted facet utilizing the inherent polarization purity.

    PubMed

    Ahn, Sangil; Ristanic, Daniela; Gansch, Roman; Reininger, Peter; Schwarzer, Clemens; MacFarland, Donald C; Detz, Hermann; Schrenk, Werner; Strasser, Gottfried

    2014-10-20

    We report on quantum cascade lasers (QCLs) with a tilted facet utilizing their polarization property. Contrary to diode lasers, QCLs generate purely TM polarized light due to the intersubband selection rules. This property enables the utilization of reflectivity in terms of only TM polarized light (TM reflectivity). The TM reflectivity is reduced by tilting the front facet, resulting in enhanced light output power from the tilted facet. The peak output power of a QCL with a facet angle of 12° are increased by 31 %. The slope efficiency of a QCL with a facet angle of 17° are increased by 43 %. Additionally, a peculiar property of TM reflectivity, the Brewster angle, is investigated by using COMSOL simulations to find its availability in QCLs.

  18. Measured and predicted root-mean-square errors in square and triangular antenna mesh facets

    NASA Technical Reports Server (NTRS)

    Fichter, W. B.

    1989-01-01

    Deflection shapes of square and equilateral triangular facets of two tricot-knit, gold plated molybdenum wire mesh antenna materials were measured and compared, on the basis of root mean square (rms) differences, with deflection shapes predicted by linear membrane theory, for several cases of biaxial mesh tension. The two mesh materials contained approximately 10 and 16 holes per linear inch, measured diagonally with respect to the course and wale directions. The deflection measurement system employed a non-contact eddy current proximity probe and an electromagnetic distance sensing probe in conjunction with a precision optical level. Despite experimental uncertainties, rms differences between measured and predicted deflection shapes suggest the following conclusions: that replacing flat antenna facets with facets conforming to parabolically curved structural members yields smaller rms surface error; that potential accuracy gains are greater for equilateral triangular facets than for square facets; and that linear membrane theory can be a useful tool in the design of tricot knit wire mesh antennas.

  19. Growth of Au@Ag core-shell pentatwinned nanorods: tuning the end facets.

    PubMed

    Zhang, Weiqing; Goh, Hao Ying Johnny; Firdoz, Shaik; Lu, Xianmao

    2013-09-16

    Au@Ag core-shell nanorods with tunable end facets are obtained by coating Au bipyramids (BPs) with Ag. The resultant nanorods exhibit a pentatwinned crystal structure with tips terminated with either {110} or {111} facets. The control over the end facets is achieved by varying the capping agents and tuning the reduction rate of Ag. Specifically, when Ag is reduced slowly, Au@Ag nanorods with flat {110} end facets are formed with cetyltrimethylammonium bromide (CTAB) as the capping agent. If CTAB is replaced with cetyltrimethylammonium chloride (CTAC), Au@Ag nanorods with tips terminated with {111} facets are obtained. However, at a high Ag reduction rate, dumbbell-shaped Au@Ag nanorods are formed, with either CTAB or CTAC as the capping agent. The morphological evolution of the nanorods in each case is closely followed and a growth mechanism is proposed. PMID:23934938

  20. Improving personality facet scores with multidimensional computer adaptive testing: an illustration with the NEO PI-R.

    PubMed

    Makransky, Guido; Mortensen, Erik Lykke; Glas, Cees A W

    2013-02-01

    Narrowly defined personality facet scores are commonly reported and used for making decisions in clinical and organizational settings. Although these facets are typically related, scoring is usually carried out for a single facet at a time. This method can be ineffective and time consuming when personality tests contain many highly correlated facets. This article investigates the possibility of increasing the precision of the NEO PI-R facet scores by scoring items with multidimensional item response theory and by efficiently administering and scoring items with multidimensional computer adaptive testing (MCAT). The increase in the precision of personality facet scores is obtained from exploiting the correlations between the facets. Results indicate that the NEO PI-R could be substantially shorter without attenuating precision when the MCAT methodology is used. Furthermore, the study shows that the MCAT methodology is particularly appropriate for constructs that have many highly correlated facets.

  1. Workflow in interventional radiology: nerve blocks and facet blocks

    NASA Astrophysics Data System (ADS)

    Siddoway, Donald; Ingeholm, Mary Lou; Burgert, Oliver; Neumuth, Thomas; Watson, Vance; Cleary, Kevin

    2006-03-01

    Workflow analysis has the potential to dramatically improve the efficiency and clinical outcomes of medical procedures. In this study, we recorded the workflow for nerve block and facet block procedures in the interventional radiology suite at Georgetown University Hospital in Washington, DC, USA. We employed a custom client/server software architecture developed by the Innovation Center for Computer Assisted Surgery (ICCAS) at the University of Leipzig, Germany. This software runs in an internet browser, and allows the user to record the actions taken by the physician during a procedure. The data recorded during the procedure is stored as an XML document, which can then be further processed. We have successfully gathered data on a number if cases using a tablet PC, and these preliminary results show the feasibility of using this software in an interventional radiology setting. We are currently accruing additional cases and when more data has been collected we will analyze the workflow of these procedures to look for inefficiencies and potential improvements.

  2. Resonant phase dynamics in 0- π Sine-Gordon facets

    NASA Astrophysics Data System (ADS)

    Rotoli, Giacomo; Stornaiuolo, Daniela; Cedergren, Karin; Leo, Antonio; Bauch, Thilo; Lombardi, Filomena; Tafuri, Francesco

    2015-09-01

    A locally phase-shifted Sine-Gordon model well accounts for the phenomenology of unconventional Josephson junctions. The phase dynamics shows resonant modes similar to Fiske modes that appear both in the presence and in the absence of the external magnetic field in standard junctions. In the latter case, they are also in competition with zero field propagation of Sine-Gordon solitons, i.e., fluxons, which give rise to the so-called zero field steps in the current-voltage (I-V) of the junction. We numerically study the I-V characteristics and the resonances magnetic field patterns for some different faceting configurations, in various dissipative regimes, as a function of temperature. The simulated dynamics of the phase is analyzed for lower-order resonances. We give evidence of a nontrivial dynamics due to the interaction of propagating fluxons with localized semifluxons. Numerical results are compared with experimental outcomes obtained on high-quality high-Tc grain boundary YBCO junctions.

  3. Theory of Electromigration of Faceted Voids in Aluminum Interconnects

    NASA Astrophysics Data System (ADS)

    Wickham, Lisa K.; Sethna, James P.

    1996-03-01

    Void--induced breakage of micron--sized aluminum wires is an important cause of failure in V.L.S.I. circuits. As an electromigration void travels through a grain in such a wire, a corresponding flux of atoms must leave the front face of the void and move to its other side. We give estimated upper bounds on this flux as a function of current density, temperature, various diffusion barriers, and surface step density. To learn about step density, we discuss ways in which the field changes equilibrium void shape and influences step nucleation rates. We conclude that the field enhances faceting on the leading void face, and find evidence for such behavior in previous experiments. In contrast, diffusion barriers from recent density functional calculations produce particle fluxes from our estimates which fall far below that given by observed void velocities, unless the step density on the leading void face is nearly one. We discuss strain, local heating, and impurity effects which might be responsible for enhanced mobility in real interconnects.

  4. V-groove faceted reflector for enhanced module output

    NASA Astrophysics Data System (ADS)

    Amick, J. A.; Kurth, W. T.

    In the manufacture of present-day photovoltaic modules, single crystal wafers of silicon serve as the starting point. Because of the high cost of the silicon, it is not economical to convert the circular wafers into square or rectangular cells, even though these cells would more nearly fill the available area in a module. Accordingly, a substantial portion, typically 20 to 25%, of the module area is not filled with silicon. Incident light falling on these 'interstitial' regions between cells is largely lost, leading to module inefficiencies. One technique for recovering a portion of the 'lost' light is to use a white, scattering background behind the cells. The cell output can generally be improved by 5 to 10%. The present study is concerned with an improved method of recovering the light falling on the interstitial regions by which nearly 50% increase in cell output has been realized in favorable cases. The method makes use of an optically transparent medium above the cells, and a series of V-groove facets provided in the interstitial regions between cells.

  5. Specific oriented metal-organic framework membranes and their facet-tuned separation performance.

    PubMed

    Mao, Yiyin; Su, Binbin; Cao, Wei; Li, Junwei; Ying, Yulong; Ying, Wen; Hou, Yajun; Sun, Luwei; Peng, Xinsheng

    2014-09-24

    Modulating the crystal morphology, or the exposed crystal facets, of metal-organic frameworks (MOFs) expands their potential applications in catalysis, adsorption, and separation. In this article, by immobilizing the citrate modulators on Au nanoparticles and subsequently being fixed on solid copper hydroxide nanostrands, a well-intergrown and oriented HKUST-1 cube crystal membrane was formed at room temperature. In contrast, in the absence of Au nanoparticles, well-intergrown and oriented cuboctahedron and octahedron membranes were formed in water/ethanol and ethanol, respectively. The gas separation performances of these HKUST-1 membranes were tuned via their exposed facets with defined pore sizes. The HKUST-1 cube membrane with exposed {001} facets demonstrated the highest permeance but lowest gas binary separation factors, while the octahedron membrane with exposed {111} facets presented the highest separation factors but lowest permeance, since the window size of {111} facets is 0.46 nm which is smaller than 0.9 nm of {001} facets. Separation of 0.38 nm CO2 from 0.55 nm SF6 was realized by the HKUST-1 octahedron membrane. As a proof of concept, this will open a new way to design MOF-related separation membranes by facet controlling. PMID:25184955

  6. What Is Down Syndrome? 1984 Digest.

    ERIC Educational Resources Information Center

    Ferrara, Dianne

    The digest presents an overview on Down Syndrome. The history of the term is traced to its association with Dr. John Langdon Down who first described the condition in 1866. Characteristics of Down Syndrome are noted, including mental retardation, short stature, epicanthic folds, reduced muscle tone, joint hyperflexibility, and premature aging.…

  7. Questions & Answers about...Marfan Syndrome.

    ERIC Educational Resources Information Center

    National Inst. of Arthritis and Musculoskeletal and Skin Diseases (NIH), Bethesda, MD.

    This fact sheet answers general questions about Marfan syndrome, a heritable condition that affects the connective tissue. It describes the characteristics of the disorder, the diagnostic process, and ways to manage symptoms. Characteristics include: (1) people with Marfan syndrome are typically very tall, slender, and loose jointed; (2) more than…

  8. Pain and musculoskeletal pain syndromes in adolescents.

    PubMed

    Zapata, Aura Ligia; Moraes, Ana Julia Pantoja; Leone, Claudio; Doria-Filho, Ulysses; Silva, Clovis Artur Almeida

    2006-06-01

    The presence of musculoskeletal pain was evaluated in adolescents. Pain was reported by 40% of respondents, benign joint hypermobility syndrome by 10%, myofascial syndrome by 5%, tendonitis by 2%, and fibromialgia by 1%. Logistical regression analysis indicated that sex and age were predictive of pain.

  9. Obtaining Content Weights for Test Specifications from Job Analysis Task Surveys: An Application of the Many-Facets Rasch Model

    ERIC Educational Resources Information Center

    Wang, Ning; Stahl, John

    2012-01-01

    This article discusses the use of the Many-Facets Rasch Model, via the FACETS computer program (Linacre, 2006a), to scale job/practice analysis survey data as well as to combine multiple rating scales into single composite weights representing the tasks' relative importance. Results from the Many-Facets Rasch Model are compared with those…

  10. Synthesis of nano-sized anatase TiO2 with reactive {001} facets using lamellar protonated titanate as precursor.

    PubMed

    Gu, Liuan; Wang, Jingyu; Cheng, Hao; Du, Yunchen; Han, Xijiang

    2012-07-14

    Nano-sized anatase TiO(2) with exposed {001} facets was synthesized from lamellar protonated titanate precursor. Owing to small size (ca. 11 nm) and high surface area (155 m(2) g(-1)), the crystals with 26.1% {001} facets exhibited markedly superior photoactivity to reference ca. 76 nm anatase TiO(2) nanosheets with 88.4% {001} facets.

  11. Facet-dependent catalytic activity of nanosheet-assembled bismuth oxyiodide microspheres in degradation of bisphenol A.

    PubMed

    Pan, Meilan; Zhang, Haijun; Gao, Guandao; Liu, Lu; Chen, Wei

    2015-05-19

    Photocatalysts with different exposed facets often exhibit different photochemical performances, but the underlying mechanisms are not fully understood. In this study, we synthesized two nanosheet-assembled bismuth oxyiodide (BiOI) microspheres with exposed (110) and (001) facets, respectively, to further investigate facet-dependent photocatalytic activity. Our experimental results showed that the BiOI microspheres with exposed (110) facets exhibited much greater catalytic activity than the BiOI microspheres with exposed (001) facets in the degradation of bisphenol A under visible light irradiation. Density functional theory calculation revealed that the (110) facets can adsorb a greater amount of O2 and, thus, form more O2(•-) and (•)OH radicals than the (001) facets. The electron spin resonance spectroscopy and radical scavenging experiments verified that the BiOI microspheres with exposed (110) facets could produce a greater amount of O2(•-) radicals than the BiOI microspheres with exposed (001) facets, and more importantly, between the two BiOI products, only the BiOI microspheres with exposed (110) facets could generate (•)OH radicals directly. The facet-dependent radical formation mechanisms were previously unidentified. The findings of this study may have important implications for the understanding of the facet-dependent photochemical performance of photocatalysts and the design of novel catalytic materials with inorganic nanostructures. PMID:25895581

  12. Improving Personality Facet Scores with Multidimensional Computer Adaptive Testing: An Illustration with the Neo Pi-R

    ERIC Educational Resources Information Center

    Makransky, Guido; Mortensen, Erik Lykke; Glas, Cees A. W.

    2013-01-01

    Narrowly defined personality facet scores are commonly reported and used for making decisions in clinical and organizational settings. Although these facets are typically related, scoring is usually carried out for a single facet at a time. This method can be ineffective and time consuming when personality tests contain many highly correlated…

  13. Diagnostic challenge: bilateral infected lumbar facet cysts - a rare cause of acute lumbar spinal stenosis and back pain

    PubMed Central

    2010-01-01

    Symptomatic synovial lumbar facet cysts are a relatively rare cause of radiculopathy and spinal stenosis. This case and brief review of the literature, details a patient who presented with acutely symptomatic bilateral spontaneously infected synovial facet (L4/5) cysts. This report highlights diagnostic clues for identifying infection of a facet cyst. PMID:20205727

  14. Facet-dependent catalytic activity of nanosheet-assembled bismuth oxyiodide microspheres in degradation of bisphenol A.

    PubMed

    Pan, Meilan; Zhang, Haijun; Gao, Guandao; Liu, Lu; Chen, Wei

    2015-05-19

    Photocatalysts with different exposed facets often exhibit different photochemical performances, but the underlying mechanisms are not fully understood. In this study, we synthesized two nanosheet-assembled bismuth oxyiodide (BiOI) microspheres with exposed (110) and (001) facets, respectively, to further investigate facet-dependent photocatalytic activity. Our experimental results showed that the BiOI microspheres with exposed (110) facets exhibited much greater catalytic activity than the BiOI microspheres with exposed (001) facets in the degradation of bisphenol A under visible light irradiation. Density functional theory calculation revealed that the (110) facets can adsorb a greater amount of O2 and, thus, form more O2(•-) and (•)OH radicals than the (001) facets. The electron spin resonance spectroscopy and radical scavenging experiments verified that the BiOI microspheres with exposed (110) facets could produce a greater amount of O2(•-) radicals than the BiOI microspheres with exposed (001) facets, and more importantly, between the two BiOI products, only the BiOI microspheres with exposed (110) facets could generate (•)OH radicals directly. The facet-dependent radical formation mechanisms were previously unidentified. The findings of this study may have important implications for the understanding of the facet-dependent photochemical performance of photocatalysts and the design of novel catalytic materials with inorganic nanostructures.

  15. Facility for Advanced Accelerator Experimental Tests at SLAC (FACET) Conceptual Design Report

    SciTech Connect

    Amann, J.; Bane, K.; /SLAC

    2009-10-30

    This Conceptual Design Report (CDR) describes the design of FACET. It will be updated to stay current with the developing design of the facility. This CDR begins as the baseline conceptual design and will evolve into an 'as-built' manual for the completed facility. The Executive Summary, Chapter 1, gives an introduction to the FACET project and describes the salient features of its design. Chapter 2 gives an overview of FACET. It describes the general parameters of the machine and the basic approaches to implementation. The FACET project does not include the implementation of specific scientific experiments either for plasma wake-field acceleration for other applications. Nonetheless, enough work has been done to define potential experiments to assure that the facility can meet the requirements of the experimental community. Chapter 3, Scientific Case, describes the planned plasma wakefield and other experiments. Chapter 4, Technical Description of FACET, describes the parameters and design of all technical systems of FACET. FACET uses the first two thirds of the existing SLAC linac to accelerate the beam to about 20GeV, and compress it with the aid of two chicanes, located in Sector 10 and Sector 20. The Sector 20 area will include a focusing system, the generic experimental area and the beam dump. Chapter 5, Management of Scientific Program, describes the management of the scientific program at FACET. Chapter 6, Environment, Safety and Health and Quality Assurance, describes the existing programs at SLAC and their application to the FACET project. It includes a preliminary analysis of safety hazards and the planned mitigation. Chapter 7, Work Breakdown Structure, describes the structure used for developing the cost estimates, which will also be used to manage the project. The chapter defines the scope of work of each element down to level 3.

  16. Progress report for FACETS (Framework Application for Core-Edge Transport Simulations): C.S. SAP

    SciTech Connect

    Epperly, T W

    2008-10-01

    The mission of the Computer Science Scientific Application Partnership (C.S. SAP) at LLNL is to develop and apply leading-edge scientific component technology to FACETS software. Contributions from LLNL's fusion energy program staff towards the underlying physics modules are described in a separate report. FACETS uses component technology to combine selectively multiple physics and solver software modules written in different languages by different institutions together in an tightly-integrated, parallel computing framework for Tokamak reactor modeling. In the past fiscal year, the C.S. SAP has focused on two primary tasks: applying Babel to connect UEDGE into the FACETS framework through UEDGE's existing Python interface and developing a next generation componentization strategy for UEDGE which avoids the use of Python. The FACETS project uses Babel to solve its language interoperability challenges. Specific accomplishments for the year include: (1) Refined SIDL interfaces for UEDGE to meet satisfy the standard interfaces required by FACETS for all physics modules. This required consensus building between framework and UEDGE developers. (2) Wrote prototype C++ driver for UEDGE to demonstrate how UEDGE can be called from C++ using Babel. (3) Supported the FACETS project by adding new features to Babel such as release number tagging, porting to new machines, and adding new configuration options. Babel modifications were delivered to FACETS by testing and publishing development snapshots in the projects software repository. (4) Assisted Tech-X Corporation in testing and debugging of a high level build system for the complete FACETS tool chain--the complete list of third-party software libraries that FACETS depends on directly or indirectly (e.g., MPI, HDF5, PACT, etc.). (5) Designed and implemented a new approach to wrapping UEDGE as a FACETS component without requiring Python. To get simulation results as soon as possible, our initial connection from the FACETS

  17. Facet-controlled facilitation of PbS nanoarchitectures by understanding nanocrystal growth

    NASA Astrophysics Data System (ADS)

    Loc, Welley Siu; Quan, Zewei; Lin, Cuikun; Pan, Jinfong; Wang, Yuxuan; Yang, Kaikun; Jian, Wen-Bin; Zhao, Bo; Wang, Howard; Fang, Jiye

    2015-11-01

    Nanostructured lead sulphide is a significant component in a number of energy-related sustainable applications such as photovoltaic cells and thermoelectric components. In many micro-packaging processes, dimensionality-controlled nano-architectures as building blocks with unique properties are required. This study investigates different facet-merging growth behaviors through a wet-chemical synthetic strategy to produce high-quality controlled nanostructures of lead sulphide in various dimensionalities. It was found that 1D nanowires or 2D nanosheets can be obtained by the merging of reactive {111}- or {110}-facets, respectively, while promoting {100} facets in the early stages after nucleation leads to the growth of 0D nanocubes. The influence of temperature, capping ligands and co-solvent in facilitating the crystal facet growth of each intermediate seed is also demonstrated. The novelty of this work is characterized by the delicate manipulation of various PbS nanoarchitectures based on the comprehension of the facet-merging evolution. The synthesis of facet-controlled PbS nanostructures could provide novel building blocks with desired properties for use in many applications.Nanostructured lead sulphide is a significant component in a number of energy-related sustainable applications such as photovoltaic cells and thermoelectric components. In many micro-packaging processes, dimensionality-controlled nano-architectures as building blocks with unique properties are required. This study investigates different facet-merging growth behaviors through a wet-chemical synthetic strategy to produce high-quality controlled nanostructures of lead sulphide in various dimensionalities. It was found that 1D nanowires or 2D nanosheets can be obtained by the merging of reactive {111}- or {110}-facets, respectively, while promoting {100} facets in the early stages after nucleation leads to the growth of 0D nanocubes. The influence of temperature, capping ligands and co-solvent in

  18. Peroneal spastic flatfoot in adolescents with accessory talar facet impingement: a preliminary report.

    PubMed

    Niki, Hisateru; Aoki, Haruhito; Hirano, Takaaki; Akiyama, Yui; Fujiya, Hiroto

    2015-07-01

    This study analyzed imaging, arthroscopic findings, and treatment responses for peroneal spastic flatfoot (PSFF) caused by talocalcaneal impingement at the accessory anterolateral talar facet (AALTF) (accessory talar facet impingement) in 13 adolescents without histories of trauma and tarsal coalition. The AALTF was determined with computed tomography and MRI. Focal abutting bone marrow edema (FABME) on MRI around the AALTF was confirmed. In seven patients who underwent AALTF resection, subtalar arthroscopy was performed. All experienced alleviation PSFF after treatment; reduction in FABME was observed. AALTF resection alone is beneficial for PSFF caused by accessory talar facet impingement when peroneal spasms are restored by an injection of local anesthesia.

  19. Transient surface modifications during singular heating events at diode laser facets

    NASA Astrophysics Data System (ADS)

    Hempel, Martin; Tomm, Jens W.; Bachmann, Alexander; Lauer, Christian; Furitsch, Michael; Strauß, Uwe; Elsaesser, Thomas

    2016-05-01

    Surface morphology changes and transient reflectance changes at diode laser facets are monitored during the catastrophic optical damage (COD) process in a single pulse operation. Time-resolved micro-reflectance spectroscopy with a streak-camera (time resolution ˜20 ns) allows us to observe the creation sequence of up to four distinct degradation seed points at a device facet within <300 ns. The shape of the COD seeds is created within <30-40 ns. Creation of non-planar facet areas by local melting represents the main mechanism behind the observed reflectivity changes. Subsequently the surface temperature decreases within the pulse which caused the COD.

  20. Butt Joint Tool Commissioning

    SciTech Connect

    Martovetsky, N N

    2007-12-06

    ITER Central Solenoid uses butt joints for connecting the pancakes in the CS module. The principles of the butt joining of the CICC were developed by the JAPT during CSMC project. The difference between the CSMC butt joint and the CS butt joint is that the CS butt joint is an in-line joint, while the CSMC is a double joint through a hairpin jumper. The CS butt joint has to carry the hoop load. The straight length of the joint is only 320 mm, and the vacuum chamber around the joint has to have a split in the clamp shell. These requirements are challenging. Fig.1 presents a CSMC joint, and Fig.2 shows a CS butt joint. The butt joint procedure was verified and demonstrated. The tool is capable of achieving all specified parameters. The vacuum in the end was a little higher than the target, which is not critical and readily correctable. We consider, tentatively that the procedure is established. Unexpectedly, we discover significant temperature nonuniformity in the joint cross section, which is not formally a violation of the specs, but is a point of concern. All testing parameters are recorded for QA purposes. We plan to modify the butt joining tool to improve its convenience of operation and provide all features necessary for production of butt joints by qualified personnel.

  1. Brown Syndrome

    MedlinePlus

    ... Does Brown syndrome cause eye problems besides abnormal eye movements? Some children with Brown syndrome have poor binocular ... In the congenital form of Brown syndrome, the eye movement problem is usually constant and unlikely to resolve ...

  2. Dravet Syndrome

    MedlinePlus

    ... NINDS Dravet Syndrome Information Page Synonym(s): Severe Myoclonic Epilepsy of Infancy (SMEI) Table of Contents (click to ... Dravet Syndrome? Dravet syndrome, also called severe myoclonic epilepsy of infancy (SMEI), is a severe form of ...

  3. Fahr's Syndrome

    MedlinePlus

    ... Awards Enhancing Diversity Find People About NINDS NINDS Fahr's Syndrome Information Page Synonym(s): Familial Idiopathic Basal Ganglia ... is being done? Clinical Trials Organizations What is Fahr's Syndrome? Fahr's Syndrome is a rare, genetically dominant, ...

  4. Cushing syndrome

    MedlinePlus

    Hypercortisolism; Cortisol excess ... The most common cause of Cushing syndrome is taking too much glucocorticosteroid medicine. This form of Cushing syndrome is called exogenous Cushing syndrome . Prednisone, dexamethasone, and prednisolone are ...

  5. Williams syndrome

    MedlinePlus

    Williams-Beuren syndrome ... Williams syndrome is caused by not having a copy of several genes. Parents may not have any family history of the condition. However, people with Williams syndrome have a 50% chance of passing the ...

  6. Local and social facets of planetary boundaries: right to nutrients

    NASA Astrophysics Data System (ADS)

    Kahiluoto, Helena; Kuisma, Miia; Kuokkanen, Anna; Mikkilä, Mirja; Linnanen, Lassi

    2015-10-01

    Anthropogenic nutrient flows exceed the planetary boundaries. The boundaries and the current excesses vary spatially. Such variations have both an ecological and a social facet. We explored the spatial variation using a bottom-up approach. The local critical boundaries were determined through the current or accumulated flow of the preceding five years before the planetary boundary criteria were met. Finland and Ethiopia served as cases with contrasting ecology and wealth. The variation in excess depends on historical global inequities in the access to nutrients. Globally, the accumulated use per capita is 2300 kg reactive nitrogen (Nr) and 200 kg phosphorus (P). For Finland, the accumulated use per capita is 3400 kg Nr and 690 kg P, whereas for Ethiopia, it is 26 kg Nr and 12 kg P. The critical N boundary in Finland is currently exceeded by 40 kg cap-1 a-1 and the accumulated excess is 65 kg cap-1 a-1, while the global current excess is 24 kg cap-1 a-1 and there is space in Ethiopia to increase even the accumulated flow. The critical P boundary is exceeded in Finland and (although less so) in Ethiopia, but for contrary reasons: (1) the excessive past inflow to the agrifood system in Finland and (2) the excessive outflow from the agrifood system triggered by deficits in inflow and waste management in Ethiopia. The critical boundaries set by Finnish marine systems are lower and those set by freshwaters are higher than the planetary boundaries downscaled per capita. The shift to dominance of internal loading in watercourses represents a tipping point. We conclude that food security within the safe boundaries requires global redistribution of nutrients in residues, soils and sediments and of rights to use nutrients. Bottom-up assessments reveal local dynamics that shed new light on the relevant boundary criteria and on estimates and remedies.

  7. Facet Model and Mathematical Morphology for Surface Characterization

    SciTech Connect

    Abidi, B.R.; Goddard, J.S.; Hunt, M.A.; Sari-Sarraf, H.

    1999-11-13

    This paper describes an algorithm for the automatic segmentation and representation of surface structures and non-uniformities in an industrial setting. The automatic image processing and analysis algorithm is developed as part of a complete on-line web characterization system of a papermaking process at the wet end. The goal is to: (1) link certain types of structures on the surface of the web to known machine parameter values, and (2) find the connection between detected structures at the beginning of the line and defects seen on the final product. Images of the pulp mixture (slurry), carried by a fast moving table, are obtained using a stroboscopic light and a CCD camera. This characterization algorithm succeeded where conventional contrast and edge detection techniques failed due to a poorly controlled environment. The images obtained have poor contrast and contain noise caused by a variety of sources. After a number of enhancement steps, conventional segmentation methods still f ailed to detect any structures and are consequently discarded. Techniques tried include the Canny edge detector, the Sobel, Roberts, and Prewitt's filters, as well as zero crossings. The facet model algorithm, is then applied to the images with various parameter settings and is found to be successful in detecting the various topographic characteristics of the surface of the slurry. Pertinent topographic elements are retained and a filtered image computed. Carefully tailored morphological operators are then applied to detect and segment regions of interest. Those regions are then selected according to their size, elongation, and orientation. Their bounding rectangles are computed and represented. Also addressed in this paper are aspects of the real time implementation of this algorithm for on-line use. The algorithm is tested on over 500 images of slurry and is found to segment and characterize nonuniformities on all 500 images.

  8. Synthesis of trapezohedral indium oxide nanoparticles with high-index {211} facets and high gas sensing activity.

    PubMed

    Han, Xiguang; Han, Xiao; Sun, Linqiang; Gao, Shengguang; Li, Liang; Kuang, Qin; Xie, Zhaoxiong; Wang, Chao

    2015-06-14

    Nanocrystals with high-index facets usually exhibit higher catalytic activities than those with only low-index facets. Trapezohedron-shaped (TS) In2O3 particles with exposed high-index {211} facets were successfully synthesized in an oleic acid (OA) and trioctylamine (TOA) system. It has been demonstrated that the gas sensing activity of TS In2O3 particles with exposed high-index {211} facets is higher than that of octahedron-shaped In2O3 particles with exposed low-index {111} facets. PMID:25930122

  9. Synthesis of trapezohedral indium oxide nanoparticles with high-index {211} facets and high gas sensing activity.

    PubMed

    Han, Xiguang; Han, Xiao; Sun, Linqiang; Gao, Shengguang; Li, Liang; Kuang, Qin; Xie, Zhaoxiong; Wang, Chao

    2015-06-14

    Nanocrystals with high-index facets usually exhibit higher catalytic activities than those with only low-index facets. Trapezohedron-shaped (TS) In2O3 particles with exposed high-index {211} facets were successfully synthesized in an oleic acid (OA) and trioctylamine (TOA) system. It has been demonstrated that the gas sensing activity of TS In2O3 particles with exposed high-index {211} facets is higher than that of octahedron-shaped In2O3 particles with exposed low-index {111} facets.

  10. Joint hypermobility: emerging disease or illness behaviour?

    PubMed

    Grahame, Rodney

    2013-12-01

    Joint hypermobility syndrome is a common clinical entity which is much misunderstood, overlooked, misdiagnosed and mistreated. It was first described in the 1960s as a purely musculoskeletal condition due to joint laxity and hypermobility occurring in otherwise healthy individuals. Some four decades later it is now perceived to be a multi-systemic heritable disorder of connective tissue with manifestations occurring far beyond the confines of the locomotor system and with ramifications potentially affecting most, if not all, of the bodily systems in one way or another. Most authorities in the field find it clinically indistinguishable from the Ehlers-Danlos syndrome--hypermobility type (formerly, EDS type III). In >50% of patients the diagnosis is delayed for ≥10 years. Failure to diagnose and treat the condition correctly results in needless pain and suffering and in many patients to a progressive decline in their quality of life and in some to a loss of independence. PMID:24298184

  11. Pressure suit joint analyzer

    NASA Technical Reports Server (NTRS)

    Vykukal, H. C.; Webbon, B. W. (Inventor)

    1982-01-01

    A measurement system for simultaneously measuring torque and angular flexure in a pressure suit joint is described. One end of a joint under test is held rigid. A torque transducer is pivotably supported on the other movable end of a joint. A potentiometer is attached to the transducer by an arm. The wiper shaft of the potentiometer is gripped by a reference arm that rotates the wiper shaft the same angle as the flexure of joint. A signal is generated by the potentiometer which is representative of the joint flexure. A compensation circuit converts the output of the transducer to a signal representative of joint torque.

  12. Distinct water activation on polar/non-polar facets of ZnO nanoparticles

    SciTech Connect

    Zhang, He; Sun, Junming; Liu, Changjun; Wang, Yong

    2015-11-01

    ZnO nanoparticles with differing dominant facets were prepared and characterized by a complimentary of techniques such as X-ray diffraction, electron microscopy, temperature programmed desorption of H2O, and Fourier transform infrared spectroscopy analysis of adsorbed D2O. For the first time, water interaction/activation is compared on ZnO polar and non-polar facets. We report that non-polar facets exhibit high activity in water activation, which favors reactions such as ketonization and steam reforming in which dissociated water is involved. The distinct water dissociation on ZnO non-polar facets could be related to its facile formation of oxygen vacancies under realistic reaction conditions.

  13. Crystal-facet-dependent metallization in electrolyte-gated rutile TiO2 single crystals.

    PubMed

    Schladt, Thomas D; Graf, Tanja; Aetukuri, Nagaphani B; Li, Mingyang; Fantini, Andrea; Jiang, Xin; Samant, Mahesh G; Parkin, Stuart S P

    2013-09-24

    The electric-field-induced metallization of insulating oxides is a powerful means of exploring and creating exotic electronic states. Here we show by the use of ionic liquid gating that two distinct facets of rutile TiO2, namely, (101) and (001), show clear evidence of metallization, with a disorder-induced metal-insulator transition at low temperatures, whereas two other facets, (110) and (100), show no substantial effects. This facet-dependent metallization can be correlated with the surface energy of the respective crystal facet and, thus, is consistent with oxygen vacancy formation and diffusion that results from the electric fields generated within the electric double layers at the ionic liquid/TiO2 interface. These effects take place at even relatively modest gate voltages.

  14. Facet-dependent electrochemical properties of Co3O4 nanocrystals toward heavy metal ions

    PubMed Central

    Yu, Xin-Yao; Meng, Qiang-Qiang; Luo, Tao; Jia, Yong; Sun, Bai; Li, Qun-Xiang; Liu, Jin-Huai; Huang, Xing-Jiu

    2013-01-01

    We revealed an interesting facet-dependent electrochemical behavior toward heavy metal ions (HMIs) based on their adsorption behaviors. The (111) facet of Co3O4 nanoplates has better electrochemical sensing performance than that of the (001) facet of Co3O4 nanocubes. Adsorption measurements and density-functional theory (DFT) calculations reveals that adsorption of HMIs is responsible for the difference of electrochemical properties. Our combined experimental and theoretical studies provide a solid hint to explain the mechanism of electrochemical detection of HMIs using nanoscale metal oxides. Furthermore, this study not only suggests a promising new strategy for designing high performance electrochemical sensing interface through the selective synthesis of nanoscale materials exposed with different well-defined facets, but also provides a deep understanding for a more sensitive and selective electroanalysis at nanomaterials modified electrodes. PMID:24097175

  15. Construct validity of the five facet mindfulness questionnaire in meditating and nonmeditating samples.

    PubMed

    Baer, Ruth A; Smith, Gregory T; Lykins, Emily; Button, Daniel; Krietemeyer, Jennifer; Sauer, Shannon; Walsh, Erin; Duggan, Danielle; Williams, J Mark G

    2008-09-01

    Previous research on assessment of mindfulness by self-report suggests that it may include five component skills: observing, describing, acting with awareness, nonjudging of inner experience, and nonreactivity to inner experience. These elements of mindfulness can be measured with the Five Facet Mindfulness Questionnaire (FFMQ). The authors investigated several aspects of the construct validity of the FFMQ in experienced meditators and nonmeditating comparison groups. Consistent with predictions, most mindfulness facets were significantly related to meditation experience and to psychological symptoms and well-being. As expected, relationships between the observing facet and psychological adjustment varied with meditation experience. Regression and mediation analyses showed that several of the facets contributed independently to the prediction of well-being and significantly mediated the relationship between meditation experience and well-being. Findings support the construct validity of the FFMQ in a combination of samples not previously investigated.

  16. Organizational culture, creative behavior, and information and communication technology (ICT) usage: a facet analysis.

    PubMed

    Carmeli, Abraham; Sternberg, Akiva; Elizur, D

    2008-04-01

    Despite the prominence of organizational culture (OC), this concept is controversial and its structure has yet to be systematically analyzed. This study develops a three-pronged formal definitional framework on the basis of facet theory (FT) and explores behavior modality, referent, and object. This facet analysis (FA) of OC accounts successfully for variation in both creative behavior at work and the usage of information and communication technologies (ICTs). An analysis of data collected from 230 employees in the financial industry indicates that a radex structure was obtained for work and ICT. The behavior modality facet ordered the space from center to periphery, and referents facet relates to the direction angles away from the origin.

  17. Consensually defined facets of personality as prospective predictors of change in depression symptoms.

    PubMed

    Naragon-Gainey, Kristin; Watson, David

    2014-08-01

    Depression has robust associations with personality, showing a strong relation with neuroticism and more moderate associations with extraversion and conscientiousness. In addition, each Big Five domain can be decomposed into narrower facets. However, we currently lack consensus as to the contents of Big Five facets, with idiosyncrasies across instruments; moreover, few studies have examined associations with depression. In the current study, community participants completed six omnibus personality inventories; self-reported depressive symptoms were assessed at baseline and 5 years later. Exploratory factor analyses suggested three to five facets in each domain, and these facets served as prospective predictors of depression in hierarchical regressions, after accounting for baseline and trait depression. In these analyses, high anger (from neuroticism), low positive emotionality (extraversion), low conventionality (conscientiousness), and low culture (openness to experiences) were significant prospective predictors of depression. Results are discussed in regard to personality structure and assessment, as well as personality-psychopathology associations.

  18. Facets of emotional awareness and associations with emotion regulation and depression.

    PubMed

    Boden, Matthew Tyler; Thompson, Renee J

    2015-06-01

    Emotion theories posit that effective emotion regulation depends upon the nuanced information provided by emotional awareness; attending to and understanding one's own emotions. Additionally, the strong associations between facets of emotional awareness and various forms of psychopathology may be partially attributable to associations with emotion regulation. These logically compelling hypotheses are largely uninvestigated, including which facets compose emotional awareness and how they relate to emotion regulation strategies and psychopathology. We used exploratory structural equation modeling of individual difference measures among a large adult sample (n = 919) recruited online. Results distinguished 4 facets of emotional awareness (type clarity, source clarity, involuntary attention to emotion, and voluntary attention to emotion) that were differentially associated with expressive suppression, acceptance of emotions, and cognitive reappraisal. Facets were associated with depression both directly and indirectly via associations with emotion regulation strategies. We discuss implications for theory and research on emotional awareness, emotion regulation, and psychopathology.

  19. GaAs-based self-aligned stripe superluminescent diodes processed normal to the cleaved facet

    NASA Astrophysics Data System (ADS)

    Ghazal, O. M. S.; Lei, D.; Childs, D. T.; Stevens, B. J.; Babazadeh, N.; Hogg, R. A.; Groom, K. M.

    2016-03-01

    We demonstrate GaAs-based superluminescent diodes (SLDs) incorporating a window-like back facet in a self-aligned stripe. SLDs are realised with low spectral modulation depth (SMD) at high power spectral density, without application of anti-reflection coatings. Such application of a window-like facet reduces effective facet reflectivity in a broadband manner. We demonstrate 30mW output power in a narrow bandwidth with only 5% SMD, outline the design criteria for high power and low SMD, and describe the deviation from a linear dependence of SMD on output power as a result of Joule heating in SLDs under continuous wave current injection. Furthermore, SLDs processed normal to the facet demonstrate output powers as high as 20mW, offering improvements in beam quality, ease of packaging and use of real estate.

  20. Crack Front Segmentation and Facet Coarsening in Mixed-Mode Fracture

    NASA Astrophysics Data System (ADS)

    Chen, Chih-Hung; Cambonie, Tristan; Lazarus, Veronique; Nicoli, Matteo; Pons, Antonio J.; Karma, Alain

    2015-12-01

    A planar crack generically segments into an array of "daughter cracks" shaped as tilted facets when loaded with both a tensile stress normal to the crack plane (mode I) and a shear stress parallel to the crack front (mode III). We investigate facet propagation and coarsening using in situ microscopy observations of fracture surfaces at different stages of quasistatic mixed-mode crack propagation and phase-field simulations. The results demonstrate that the bifurcation from propagating a planar to segmented crack front is strongly subcritical, reconciling previous theoretical predictions of linear stability analysis with experimental observations. They further show that facet coarsening is a self-similar process driven by a spatial period-doubling instability of facet arrays.

  1. A facet approach to extending the normative component of the theory of reasoned action.

    PubMed

    Donald, I; Cooper, S R

    2001-12-01

    Using facet theory, this study addresses the weak explanatory power of normative influence in theories of reasoned action or planned behaviour. A broad normative construct is hypothesized as being characterized by two facets--social unit and behavioural modality--each of which is examined in relation to recreational drug use. A questionnaire was developed from the facets and administered to undergraduate students. Data (N = 181) were analysed using Smallest Space Analysis (SSA). The results suggest that the facets provide an adequate description of the normative construct and that personal and social normative beliefs, behavioural norms and behavioural intentions can be distinguished empirically. The results also lend partial support to Ajzen's (1988; Ajzen & Fishbein, 1977) principle of compatibility. Implications for how social influence is operationalized and conceptualized are also discussed.

  2. Erosion Triangular Facets as Markers of Order in an Open Dissipative System

    NASA Astrophysics Data System (ADS)

    Paliaga, Guido

    2015-07-01

    The complexity and non-linearity of the morphogenetic system which is responsible for shaping the Earth's surface have been widely recognised by many authors who have documented the fractal nature of erosion. In this paper, two peculiar kinds of landforms are compared to point out ordered structures, i.e. triangular facets that arise in different geomorphic systems, due to the principle of morphologic convergence. Occurrence of triangular facets has been documented in mountainous areas in relation to base level changes and hydrographical network evolution; similarly shaped landforms are present even in recent tectonic uplift areas along faults. The spatial distribution of the two kinds of facets has been investigated in two river basins located in Liguria (northern Italy) and in a mountainous area in Oman. The results of this analysis document the different spatial features of the two kinds of facets.

  3. Organizational culture, creative behavior, and information and communication technology (ICT) usage: a facet analysis.

    PubMed

    Carmeli, Abraham; Sternberg, Akiva; Elizur, D

    2008-04-01

    Despite the prominence of organizational culture (OC), this concept is controversial and its structure has yet to be systematically analyzed. This study develops a three-pronged formal definitional framework on the basis of facet theory (FT) and explores behavior modality, referent, and object. This facet analysis (FA) of OC accounts successfully for variation in both creative behavior at work and the usage of information and communication technologies (ICTs). An analysis of data collected from 230 employees in the financial industry indicates that a radex structure was obtained for work and ICT. The behavior modality facet ordered the space from center to periphery, and referents facet relates to the direction angles away from the origin. PMID:18422410

  4. Photometric model of diffuse surfaces described as a distribution of interfaced Lambertian facets.

    PubMed

    Simonot, Lionel

    2009-10-20

    The Lambertian model for diffuse reflection is widely used for the sake of its simplicity. Nevertheless, this model is known to be inaccurate in describing a lot of real-world objects, including those that present a matte surface. To overcome this difficulty, we propose a photometric model where the surfaces are described as a distribution of facets where each facet consists of a flat interface on a Lambertian background. Compared to the Lambertian model, it includes two additional physical parameters: an interface roughness parameter and the ratio between the refractive indices of the background binder and of the upper medium. The Torrance-Sparrow model--distribution of strictly specular facets--and the Oren-Nayar model--distribution of strictly Lambertian facets--appear as special cases. PMID:19844317

  5. A facet approach to extending the normative component of the theory of reasoned action.

    PubMed

    Donald, I; Cooper, S R

    2001-12-01

    Using facet theory, this study addresses the weak explanatory power of normative influence in theories of reasoned action or planned behaviour. A broad normative construct is hypothesized as being characterized by two facets--social unit and behavioural modality--each of which is examined in relation to recreational drug use. A questionnaire was developed from the facets and administered to undergraduate students. Data (N = 181) were analysed using Smallest Space Analysis (SSA). The results suggest that the facets provide an adequate description of the normative construct and that personal and social normative beliefs, behavioural norms and behavioural intentions can be distinguished empirically. The results also lend partial support to Ajzen's (1988; Ajzen & Fishbein, 1977) principle of compatibility. Implications for how social influence is operationalized and conceptualized are also discussed. PMID:11795070

  6. Electrostatics-driven assembly of uni-lamellar catanionic facetted vesicles

    NASA Astrophysics Data System (ADS)

    Leung, Cheuk-Yui; Palmer, Liam; Kewalramani, Sumit; Sknepnek, Rastko; Vernizzi, Graziano; Greenfield, Megan; Stupp, Samuel; Bedzyk, Michael; Olvera de La Cruz, Monica

    2012-02-01

    Nature utilizes shape to generate function. Organelle and halophilic bacteria wall envelopes, for example, adopt various polyhedral shapes to compartmentalize matter. The origin of these shapes is unknown. A large variety of shell geometries, either fully faceted polyhedra or mixed Janus-like vesicles with faceted and curved domains that resemble cellular shells can be generated by coassembling water-insoluble anionic (--1) amphiphiles with high valence cationic (+2 and +3) amphiphiles. Electron microscopy, X-ray scattering, theory and simulations demonstrate that the resulting faceted ionic shells are crystalline, and stable at high salt concentrations. The crystallization of the co-assembled single tail amphiphiles is induced by ionic correlations, and modified by the solution pH. This work promotes the design of faceted shapes for various applications and improves our understanding of the origin of polyhedral shells in nature.

  7. Effects of CeO2 Support Facets on VOx/CeO2 Catalysts in Oxidative Dehydrogenation of Methanol

    SciTech Connect

    Li, Yan; Wei, Zhehao; Gao, Feng; Kovarik, Libor; Peden, Charles HF; Wang, Yong

    2014-05-13

    CeO2 supports with dominating facets, i.e., low index (100), (110) and (111) facets, are prepared. The facet effects on the structure and catalytic performance of supported vanadium oxide catalysts are investigated using oxidative dehydrogenation of methanol as a model reaction. In the presence of mixed facets, Infrared and Raman characterizations demonstrate that surface vanadia species preferentially deposit on CeO2 (100) facets, presumably because of its higher surface energy. At the same surface vanadium densities, VOx species on (100) facets show better dispersion, followed by (110) and (111) facets. The VOx species on CeO2 nanorods with (110) and (100) facets display higher activity and lower apparent activation energies compared to that on CeO2 nanopolyhedras with dominating (111) facets and CeO2 nanocubes with dominating (100) facets. The higher activity for VOx/CeO2(110) might be related to the more abundant oxygen vacancies present on the (110) facets, evidenced from Raman spectroscopic measurements.

  8. Plasma Wakefield Acceleration and FACET - Facilities for Accelerator Science and Experimental Test Beams at SLAC

    ScienceCinema

    Andrei Seryi

    2016-07-12

    Plasma wakefield acceleration is one of the most promising approaches to advancing accelerator technology. This approach offers a potential 1,000-fold or more increase in acceleration over a given distance, compared to existing accelerators.  FACET, enabled by the Recovery Act funds, will study plasma acceleration, using short, intense pulses of electrons and positrons. In this lecture, the physics of plasma acceleration and features of FACET will be presented.  

  9. Aberrations of a facet-type transmission grating for cosmic x-ray and XUV spectroscopy.

    PubMed

    Beuermann, K P; Bräuninger, H; Trümper, J

    1978-08-01

    The aberrations of various types of curved constant-period transmission gratings are discussed, using Fermat's principle. We show that optimal performance is achieved with a grating assembled from individual facets which form a nonclosed surface. For this geometry, primary coma and astigmatism are proportional to the facet size and, hence, may be adapted to the angular resolution of a Wolter-type telescope. PMID:20203778

  10. Nonlinear stress analysis of the whole lumbar spine in torsion--mechanics of facet articulation.

    PubMed

    Shirazi-Adl, A

    1994-03-01

    The response of the whole ligamentous lumbar spine in axial torsion is studied. Attention is focused on the inter-segmental variations, role of articular facets, presence of coupled movements, intervertebral stresses and the effects of a structural alteration at a level on the response. A detailed three-dimensional finite element model (L1-S1) was used for nonlinear stress analyses under torques of up to 15 N m. In right axial torque, extra cases of larger gap limit for more effective articulation, of loss of L4-L5 disc fluid content, and of removal of L4-L5 compression facet were also studied. The intersegmental results varied from one level to the next. The facet contact occurred at the lateral posterior regions of articular surfaces. The interference gap distance between facet articular surfaces, and not the orientation of articular surfaces, was the primary factor in the relative effectiveness of facets in resisting torsion. Coupled motions of upward translation and flexion rotation were noted at all levels under torques in both left and right directions. Loss of disc fluid content at the L4-L5 level resulted in larger facet contact force and axial rotation at the same level. Removal of the L4-L5 compression facet substantially increased the axial rotation, intradiscal pressure, maximum fibre strain, and strains in capsular ligaments at the same L4-L5 level. In axial torque, the disc failure appeared to be unlikely. Relatively large facet forces were generated that further increased with a loss in disc fluid content. PMID:8051189

  11. Fabrication of dry etched and subsequently passivated laser facets in GaAs/AlGaAs

    SciTech Connect

    Deichsel, Eckard; Franz, Gerhard

    2004-09-01

    The aging behavior of edge emitting laser diodes based on GaAs/AlGaAs is investigated by comparing devices with facets that are alternatively cleaved or dry etched and consecutively treated with H{sub 2}S. In this work we demonstrate that an in situ exposure to H{sub 2}S gas is not sufficient to prevent ageing but an additional plasma treatment is rather required to obtain comparable ageing results to lasers with cleaved facets.

  12. Branched Au Nanostructures Enriched with a Uniform Facet: Facile Synthesis and Catalytic Performances

    PubMed Central

    Zhu, Mingshan; Lei, Bin; Ren, Fangfang; Chen, Penglei; Shen, Yunfan; Guan, Bo; Du, Yukou; Li, Tiesheng; Liu, Minghua

    2014-01-01

    Well–defined noble metal nanocrystals (NMNCs) of a unique morphology yet a uniform facet have attracted broad interests. In this regard, those with a highly branched architecture have gained particular attention. Most of the currently existing branched NMNCs, however, are enclosed by mixed facets. We now report that branched Au nanoarchitectures could be facilely fabricated by mixing an aqueous solution of KAuCl4, an aqueous dispersion of graphene oxide, and ethanol under ambient conditions. Interestingly, unilike the conventional branched NMNCs, our unique Au nanostructures are predominately enriched with a uniform facet of {111}. Compared to the spherical Au nanostructures exposed with mixed facets, our branched nanospecies of a uniform facet display superior catalytic performances both for the catalytic reduction of 4–nitrophenol and the electrocatalytic oxidation of methanol. Our investigation represents the first example that Au nanostructures simultaneously featured with a highly branched architecture and a uniform crystal facet could be formulated. Our unique Au nanostructures provide a fundamental yet new scientific forum to disclose the correlation between the surface atomic arrangement and the catalytic performances of branched NMNCs. PMID:24918973

  13. Deformation due to migration of faceted ? twin boundaries in magnesium and cobalt

    NASA Astrophysics Data System (ADS)

    Ostapovets, Andriy; Buršík, Jiří; Gröger, Roman

    2015-12-01

    Recent experimental observations show that ? twin boundaries in hexagonal close-packed (hcp) metals are frequently faceted. The objective of this paper is to investigate the influence of this faceting on the strain produced by twinning. We show that basal-prismatic (BP) facets are terminated by opposite disclinations and the migration of these facets along a straight ? twin boundary produces ordinary twinning shear. On the other hand, joining conjugate twins gives rise to BP facets terminated on the parent twin boundaries by identical disclinations. In this case, the strain produced by the migration of BP facets is an average between the strains produced by the individual conjugate twins. These theoretical studies are complemented by two EBSD measurements on cobalt that is closely related to magnesium. The misorientation profiles measured across two conjugate twin boundaries yield a misfit of approx. 7° consistent with the theoretical prediction that the corner of a twin embryo is terminated by two identical disclinations, each accommodating a misfit of 3.7°.

  14. Facet-controlled facilitation of PbS nanoarchitectures by understanding nanocrystal growth.

    PubMed

    Loc, Welley Siu; Quan, Zewei; Lin, Cuikun; Pan, Jinfong; Wang, Yuxuan; Yang, Kaikun; Jian, Wen-Bin; Zhao, Bo; Wang, Howard; Fang, Jiye

    2015-12-01

    Nanostructured lead sulphide is a significant component in a number of energy-related sustainable applications such as photovoltaic cells and thermoelectric components. In many micro-packaging processes, dimensionality-controlled nano-architectures as building blocks with unique properties are required. This study investigates different facet-merging growth behaviors through a wet-chemical synthetic strategy to produce high-quality controlled nanostructures of lead sulphide in various dimensionalities. It was found that 1D nanowires or 2D nanosheets can be obtained by the merging of reactive {111}- or {110}-facets, respectively, while promoting {100} facets in the early stages after nucleation leads to the growth of 0D nanocubes. The influence of temperature, capping ligands and co-solvent in facilitating the crystal facet growth of each intermediate seed is also demonstrated. The novelty of this work is characterized by the delicate manipulation of various PbS nanoarchitectures based on the comprehension of the facet-merging evolution. The synthesis of facet-controlled PbS nanostructures could provide novel building blocks with desired properties for use in many applications. PMID:26514694

  15. AgI microplate monocrystals with polar {0001} facets: spontaneous photocarrier separation and enhanced photocatalytic activity.

    PubMed

    Kuang, Qin; Zheng, Xiaoli; Yang, Shihe

    2014-02-24

    Elucidating the facet-dependent photocatalytic activity of semiconductor photocatalysts is important in improving the overall efficiency of photocatalysis. Furthermore, combining facet control with selective deposition of oxidation and/or reduction cocatalysts on specific faces of semiconductor photocatalysts is potentially an effective strategy to synergistically optimize the functionality of photocatalysts. In the present study, high-purity wurtzite-type β-AgI platelet microcrystals with polar {0001} facets were prepared by a facile polyvinylpyrrolidone-assisted precipitation reaction. The polar-faceted AgI microplates were used as archetypes to demonstrate preferential diametric migration (i.e., effective separation) of photogenerated electrons and holes along the c axis. Such vectorial electron-hole separation stems from the asymmetric surface structures, which give rise to distinct photoexcited reaction behaviors on the ±(0001) polar facets of wurtzite-type semiconductors. Furthermore, on selective deposition of Ag and MnOx (1.5facets, respectively, photocatalytic activity of the AgI microplates in degrading organic pollutants was dramatically enhanced thanks to the broad light-absorption range, strong dye-adsorption ability, and effective spatial separation of photocarriers. PMID:24449437

  16. Culture - joint fluid

    MedlinePlus

    Joint fluid culture ... fungi, or viruses grow. This is called a culture. If these germs are detected, other tests may ... is no special preparation needed for the lab culture. How to prepare for the removal of joint ...

  17. Temporomandibular Joint Dysfunction

    MedlinePlus

    The temporomandibular joint (TMJ) connects your jaw to the side of your head. When it works well, it enables you to ... For people with TMJ dysfunction, problems with the joint and muscles around it may cause Pain that ...

  18. Large displacement spherical joint

    DOEpatents

    Bieg, Lothar F.; Benavides, Gilbert L.

    2002-01-01

    A new class of spherical joints has a very large accessible full cone angle, a property which is beneficial for a wide range of applications. Despite the large cone angles, these joints move freely without singularities.

  19. Hip joint replacement

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002975.htm Hip joint replacement To use the sharing features on this page, please enable JavaScript. Hip joint replacement is surgery to replace all or part ...

  20. [Total temporomandibular joint prostheses].

    PubMed

    Zwetyenga, N; Amroun, S; Wajszczak, B-L; Moris, V

    2016-09-01

    The temporomandibular joint (TMJ) is probably the most complex human joint. As in all joints, its prosthetic replacement may be indicated in selected cases. Significant advances have been made in the design of TMJ prostheses during the last three decades and the indications have been clarified. The aim of our work was to make an update on the current total TMJ total joint replacement. Indications, contraindications, prosthetic components, advantages, disadvantages, reasons for failure or reoperation, virtual planning and surgical protocol have been exposed.

  1. Joint Enrollment Report, 2014

    ERIC Educational Resources Information Center

    Iowa Department of Education, 2014

    2014-01-01

    The Iowa Department of Education collects information on joint enrollment in Iowa's 15 community colleges. Jointly enrolled students are high school students enrolled in community college credit coursework. Most jointly enrolled students enroll through Senior Year Plus (SYP) programs such as Postsecondary Enrollment Options (PSEO) and concurrent…

  2. Arch & Chord Joint Detail; Crossbracing Center Joint Detail; Chord, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Arch & Chord Joint Detail; Crossbracing Center Joint Detail; Chord, Panel Post, Tie & Diagonal Brace Joint Detail; Chord, Panel Post, Tie & Crossbracing Joint Detail - Dunlapsville Covered Bridge, Spanning East Fork Whitewater River, Dunlapsville, Union County, IN

  3. Articular geometry of the medial tarsometatarsal joint in the foot: comparison of metatarsus primus adductus and metatarsus primus rectus.

    PubMed

    Dykyj, D; Ateshian, G A; Trepal, M J; MacDonald, L R

    2001-01-01

    The three-dimensional surface geometry of the medial tarsometatarsal joint ("first metatarsocuneiform") of the first ray was analyzed to determine if the shape of the joint is distinct in the medially deviated first metatarsal with metatarsus primus adductus (MPA). Clinical evaluation of 29 cadaver feet identified 13 feet with MPA and 16 with metatarsus primus rectus (MPR). Three-dimensional (3D) coordinates x, y, z of the first metatarsal and medial cuneiform joint facets of the feet were digitized on a Coordinate Measuring Machine (accuracy = 0.01 mm) and the data fitted with B-spline surfaces from which 3D curvature maps were generated. Comparison of means of surface-averaged maximum and minimum principal curvatures and root-mean-square curvatures showed significant (p < .0005) differences between the MPA and MPR subsets, male and female subsets, and metatarsal and cuneiform subsets. These results show that the articular shape of the medial tarsometatarsal joint in feet with MPA is significantly less contoured, or is flatter, than the same joint in normal or MPR feet. Results also showed that the female joints are more curved than male joints, and that metatarsal and cuneiform facets closely conform in shape to each other. These preliminary results may be related to questions concerning the anatomical and functional basis for the first metatarsal deviation, for radiographic presentation of the joint and surgical options in correcting related forefoot deformities. PMID:11777231

  4. Joint custody: preliminary impressions.

    PubMed

    Awad, G A

    1983-02-01

    Joint custody is currently a popular and debatable issue. It is felt that some of the controversy is due to the lack of agreement on a definition. Following some examples of the differences in personal and judicial definitions of joint custody, a classification of custody is offered. Four types of custody arrangements are described: Absolute Sole Custody, Sole Custody, Non-Alternating Joint Custody (disputed and undisputed) and Alternating Joint Custody (disputed and undisputed). A critical review of the literature follows. Finally, clinical impressions about the two types of joint custody are discussed. PMID:6839267

  5. Facets : a Cloudcompare Plugin to Extract Geological Planes from Unstructured 3d Point Clouds

    NASA Astrophysics Data System (ADS)

    Dewez, T. J. B.; Girardeau-Montaut, D.; Allanic, C.; Rohmer, J.

    2016-06-01

    Geological planar facets (stratification, fault, joint…) are key features to unravel the tectonic history of rock outcrop or appreciate the stability of a hazardous rock cliff. Measuring their spatial attitude (dip and strike) is generally performed by hand with a compass/clinometer, which is time consuming, requires some degree of censoring (i.e. refusing to measure some features judged unimportant at the time), is not always possible for fractures higher up on the outcrop and is somewhat hazardous. 3D virtual geological outcrop hold the potential to alleviate these issues. Efficiently segmenting massive 3D point clouds into individual planar facets, inside a convenient software environment was lacking. FACETS is a dedicated plugin within CloudCompare v2.6.2 (http://cloudcompare.org/ ) implemented to perform planar facet extraction, calculate their dip and dip direction (i.e. azimuth of steepest decent) and report the extracted data in interactive stereograms. Two algorithms perform the segmentation: Kd-Tree and Fast Marching. Both divide the point cloud into sub-cells, then compute elementary planar objects and aggregate them progressively according to a planeity threshold into polygons. The boundaries of the polygons are adjusted around segmented points with a tension parameter, and the facet polygons can be exported as 3D polygon shapefiles towards third party GIS software or simply as ASCII comma separated files. One of the great features of FACETS is the capability to explore planar objects but also 3D points with normals with the stereogram tool. Poles can be readily displayed, queried and manually segmented interactively. The plugin blends seamlessly into CloudCompare to leverage all its other 3D point cloud manipulation features. A demonstration of the tool is presented to illustrate these different features. While designed for geological applications, FACETS could be more widely applied to any planar

  6. Paraneoplastic palmar fasciitis and polyarthritis syndrome.

    PubMed

    Santra, G

    2009-01-01

    Palmar fasciitis and polyarthritis syndrome is a rare paraneoplastic syndrome that has been reported mainly for ovarian cancers. It is thought to be a tumour-associated autoimmune disorder. It is associated with polyarthritis and rapid flexion contractures of hands with palmar nodules due to palmar fasciitis. Similar paraneoplastic features in gastric cancers have seldom been reported. Here, I am reporting a case of paraneoplastic syndrome of metastatic gastric adenocarcinoma with polyarthritis of hands and contractures of multiple joints with asymmetric clubbing (right hand more than left hand) and hyperpigmentation over back of hands and fingers. Hyperpigmentation and asymmetric clubbing have not been reported in literature in palmar fasciitis and polyarthritis syndrome.

  7. Temporomandibular joint osteoarthrosis and temporomandibular joint hypermobility.

    PubMed

    Dijkstra, P U; de Bont, L G; de Leeuw, R; Stegenga, B; Boering, G

    1993-10-01

    For studying the relationship between condylar hypermobility of the temporomandibular joint (TMJ) and osteoarthrosis (OA), 13 patients with bilateral condylar hypermobility were evaluated clinically and radiographically, 30 years after non-surgical treatment. The evaluation included range of motion, joint and muscle tenderness to palpation, joint sounds and masticatory function. Radiographs of the TMJs were evaluated for the absence or presence of degenerative changes. The hypermobile group (HG) was compared with a control group (CG) (n = 13). The CG was evaluated in the same way as the HG. Statistics included t-tests (to compare ranges of motion in the HG over time and to compare ranges of motion in HG and CG), non-parametric tests (to compare tenderness of muscles and joints, joint sounds, masticatory function and radiographic changes over time in the HG). The tests were also used to compare the same variables between the HG and CG group. The groups' only difference was the presence of radiographic signs of OA. In the HG the number of joints with radiographic degenerative changes increased significantly over time and was significantly higher than the CG. Clinically and functionally, the HG and CG did not differ. Therefore, it is concluded that TMJ hypermobility is a subsidiary factor in the development of TMJ OA. PMID:8118897

  8. Coracoclavicular joint: osteologic study of 1020 human clavicles

    PubMed Central

    Gumina, S; Salvatore, M; De Santis, P; Orsina, L; Postacchini, F

    2002-01-01

    We examined 1020 dry clavicles from cadavers of Italian origin to determine the prevalence of the coracoclavicular joint (ccj), a diarthrotic synovial joint occasionally present between the conoid tubercle of the clavicle and the superior surface of the horizontal part of the coracoid process. Five hundred and nine clavicles from individuals of different ages were submitted to X-ray examination. Using radiography, we measured the entire length and the index of sinuosity of the anterior lateral curve, on which the distance between the conoid tubercle and the coracoid process depends. We also used radiography to record the differences in prevalence of arthritis in two neighbouring joints, the acromioclavicular and sternoclavicular joints. Of the 1020 clavicles, eight (0.8%) displayed the articular facet of the ccj. No statistical correlation was found between clavicular length and the index of sinuosity of the anterior lateral curve. The prevalence of arthritis in clavicles with ccj was higher than that revealed in clavicles without ccj. The prevalence of ccj in the studied clavicles is lower than that observed in Asian cohorts. Furthermore, ccj is not conditioned by either length or sinuosity of the anterior lateral curve of the clavicle. Finally, the assumption that ccj is a predisposing factor for degenerative changes of neighbouring joints is statistically justified. PMID:12489763

  9. Facet-dependent electrical conductivity properties of Cu2O crystals.

    PubMed

    Tan, Chih-Shan; Hsu, Shih-Chen; Ke, Wei-Hong; Chen, Lih-Juann; Huang, Michael H

    2015-03-11

    It is interesting to examine facet-dependent electrical properties of single Cu2O crystals, because such study greatly advances our understanding of various facet effects exhibited by semiconductors. We show a Cu2O octahedron is highly conductive, a cube is moderately conductive, and a rhombic dodecahedron is nonconductive. The conductivity differences are ascribed to the presence of a thin surface layer having different degrees of band bending. When electrical connection was made on two different facets of a rhombicuboctahedron, a diode-like response was obtained, demonstrating the potential of using single polyhedral nanocrystals as functional electronic components. Density of state (DOS) plots for three layers of Cu2O (111), (100), and (110) planes show respective metallic, semimetal, and semiconducting band structures. By examining DOS plots for varying number of planes, the surface layer thicknesses responsible for the facet-dependent electrical properties of Cu2O crystals have been determined to be below 1.5 nm for these facets.

  10. Substrate Facet Effect on the Growth of Monolayer MoS2 on Au Foils.

    PubMed

    Shi, Jianping; Zhang, Xiaona; Ma, Donglin; Zhu, Jianbao; Zhang, Yu; Guo, Zhenxi; Yao, Yu; Ji, Qingqing; Song, Xiuju; Zhang, Yanshuo; Li, Cong; Liu, Zhongfan; Zhu, Wenguang; Zhang, Yanfeng

    2015-04-28

    MoS2 on polycrystalline metal substrates emerges as an intriguing growth system compared to that on insulating substrates due to its direct application as an electrocatalyst in hydrogen evolution. However, the growth is still indistinct with regard to the effects of the inevitably evolved facets. Herein, we demonstrate for the first time that the crystallography of Au foil substrates can mediate a strong effect on the growth of monolayer MoS2, where large-domain single-crystal MoS2 triangles are more preferentially evolved on Au(100) and Au(110) facets than on Au(111) at relative high growth temperatures (>680 °C). Intriguingly, this substrate effect can be weakened at a low growth temperature (∼530 °C), reflected with uniform distributions of domain size and nucleation density among the different facets. The preferential nucleation and growth on some specific Au facets are explained from the facet-dependent binding energy of MoS2 according to density functional theory calculations. In brief, this work should shed light on the effect of substrate crystallography on the synthesis of monolayer MoS2, thus paving the way for achieving batch-produced, large-domain or domain size-tunable growth through an appropriate selection of the growth substrate.

  11. Progress report for FACETS (Framework Application for Core-Edge Transport Simulations)

    SciTech Connect

    Epperly, T W

    2009-04-20

    This role of this computer science SAP is to facilitate FACETS design and development by contributing CCA component technology and new application-specific technology. From a software perspective, the FACETS project is a very complex project. It is a combination of legacy software written in Fortran, Python, and C++ by various coding groups along with new software modules being written from scratch. The FACETS team is spread among 11 organizations and is geographically distributed from coast to coast. The fusion physics modules to be incorporated vary in terms of the model dimensions, typical time scale, and type of interactions with other components. Because FACETS is a complex project, it requires a component-based framework to facilitate the definition and composition of scientific applications from a suite of available fusion physics components. Component architectures have proven themselves in the business world and more recently in the scientific computing world. The CS SAP contributes fundamental tools like Babel to the FACETS framework and helps develop application-specific interfaces appropriate for the fusion physics modules.

  12. Substrate Facet Effect on the Growth of Monolayer MoS2 on Au Foils.

    PubMed

    Shi, Jianping; Zhang, Xiaona; Ma, Donglin; Zhu, Jianbao; Zhang, Yu; Guo, Zhenxi; Yao, Yu; Ji, Qingqing; Song, Xiuju; Zhang, Yanshuo; Li, Cong; Liu, Zhongfan; Zhu, Wenguang; Zhang, Yanfeng

    2015-04-28

    MoS2 on polycrystalline metal substrates emerges as an intriguing growth system compared to that on insulating substrates due to its direct application as an electrocatalyst in hydrogen evolution. However, the growth is still indistinct with regard to the effects of the inevitably evolved facets. Herein, we demonstrate for the first time that the crystallography of Au foil substrates can mediate a strong effect on the growth of monolayer MoS2, where large-domain single-crystal MoS2 triangles are more preferentially evolved on Au(100) and Au(110) facets than on Au(111) at relative high growth temperatures (>680 °C). Intriguingly, this substrate effect can be weakened at a low growth temperature (∼530 °C), reflected with uniform distributions of domain size and nucleation density among the different facets. The preferential nucleation and growth on some specific Au facets are explained from the facet-dependent binding energy of MoS2 according to density functional theory calculations. In brief, this work should shed light on the effect of substrate crystallography on the synthesis of monolayer MoS2, thus paving the way for achieving batch-produced, large-domain or domain size-tunable growth through an appropriate selection of the growth substrate. PMID:25801730

  13. Defeaturing CAD models using a geometry-based size field and facet-based reduction operators.

    SciTech Connect

    Quadros, William Roshan; Owen, Steven James

    2010-04-01

    We propose a method to automatically defeature a CAD model by detecting irrelevant features using a geometry-based size field and a method to remove the irrelevant features via facet-based operations on a discrete representation. A discrete B-Rep model is first created by obtaining a faceted representation of the CAD entities. The candidate facet entities are then marked for reduction by using a geometry-based size field. This is accomplished by estimating local mesh sizes based on geometric criteria. If the field value at a facet entity goes below a user specified threshold value then it is identified as an irrelevant feature and is marked for reduction. The reduction of marked facet entities is primarily performed using an edge collapse operator. Care is taken to retain a valid geometry and topology of the discrete model throughout the procedure. The original model is not altered as the defeaturing is performed on a separate discrete model. Associativity between the entities of the discrete model and that of original CAD model is maintained in order to decode the attributes and boundary conditions applied on the original CAD entities onto the mesh via the entities of the discrete model. Example models are presented to illustrate the effectiveness of the proposed approach.

  14. Large-Scale Synthesis of Palladium Concave Nanocubes with High-Index Facets for Sustainable Enhanced Catalytic Performance

    NASA Astrophysics Data System (ADS)

    Xie, Xiaobin; Gao, Guanhui; Pan, Zhengyin; Wang, Tingjun; Meng, Xiaoqing; Cai, Lintao

    2015-02-01

    The catalytic activity of palladium (Pd) nanostructures highly relies on their size and morphology, especially enclosed with high-index facets, which provide more active sites so as to enhance their catalytic performance comparing with their low-index facet counterparts. Herein, Pd concave nanocubes enclosed with {730} facets by a one-pot scalable liquid method, with various high-index facets are synthesized via tuning reduction kinetics. Due to their high-index facets, the Pd concave nanocubes exhibit much higher electrocatalytic activity and stability for methanol oxidation than the Pd nanocubes enclosed by {100} facets and commercial Pd/C. Furthermore, we scale up synthesis of Pd concave nanocubes by expanding the volume of all species to fifty times with high-yield production.

  15. Mindfulness facets, trait emotional intelligence, emotional distress, and multiple health behaviors: A serial two-mediator model.

    PubMed

    Jacobs, Ingo; Wollny, Anna; Sim, Chu-Won; Horsch, Antje

    2016-06-01

    In the present study, we tested a serial mindfulness facets-trait emotional intelligence (TEI)-emotional distress-multiple health behaviors mediation model in a sample of N = 427 German-speaking occupational therapists. The mindfulness facets-TEI-emotional distress section of the mediation model revealed partial mediation for the mindfulness facets Act with awareness (Act/Aware) and Accept without judgment (Accept); inconsistent mediation was found for the Describe facet. The serial two-mediator model included three mediational pathways that may link each of the four mindfulness facets with multiple health behaviors. Eight out of 12 indirect effects reached significance and fully mediated the links between Act/Aware and Describe to multiple health behaviors; partial mediation was found for Accept. The mindfulness facet Observe was most relevant for multiple health behaviors, but its relation was not amenable to mediation. Implications of the findings will be discussed.

  16. Mindfulness facets, trait emotional intelligence, emotional distress, and multiple health behaviors: A serial two-mediator model.

    PubMed

    Jacobs, Ingo; Wollny, Anna; Sim, Chu-Won; Horsch, Antje

    2016-06-01

    In the present study, we tested a serial mindfulness facets-trait emotional intelligence (TEI)-emotional distress-multiple health behaviors mediation model in a sample of N = 427 German-speaking occupational therapists. The mindfulness facets-TEI-emotional distress section of the mediation model revealed partial mediation for the mindfulness facets Act with awareness (Act/Aware) and Accept without judgment (Accept); inconsistent mediation was found for the Describe facet. The serial two-mediator model included three mediational pathways that may link each of the four mindfulness facets with multiple health behaviors. Eight out of 12 indirect effects reached significance and fully mediated the links between Act/Aware and Describe to multiple health behaviors; partial mediation was found for Accept. The mindfulness facet Observe was most relevant for multiple health behaviors, but its relation was not amenable to mediation. Implications of the findings will be discussed. PMID:27062306

  17. Multiple pterygium syndrome: mimicking the findings of Turner syndrome.

    PubMed

    Güven, Ayla; Kirmizibekmez, Heves

    2011-01-01

    Multiple pterygium syndrome (MPS or Escobar syndrome) is a rare, generally autosomal recessive disorder characterized by multiple congenital joint contractures and multiple skin webs. An 11.5-year-old girl with a working diagnosis of Turner syndrome (TS) was referred for her phenotypic features and growth retardation. Pterygium of the neck, low posterior hairline, widely spaced nipples, cubitus valgus, upslanting palpebral fissures, hypertelorism, micrognathia, low-set ears, downturning corners of the mouth, long philtrum, high-arched palate, digital and intercrural webbings, and aplasia of the labia majora were indicative of MPS (Escobar syndrome). Her mental status was normal. Facial asymmetry was present due to cervical webs. Normal karyotype, gonadal functions, and cardiac and urinary system findings helped in excluding TS. Genetic diseases associated with skin webs were revised in differential diagnosis. PMID:22308873

  18. Endocannabinoid System: A Multi-Facet Therapeutic Target.

    PubMed

    Kaur, Rimplejeet; Ambwani, Sneha R; Singh, Surjit

    2016-01-01

    Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by man for recreational and medicinal purposes since many centuries. Study of cannabinoids was at bay for very long time and its therapeutic value could not be adequately harnessed due to its legal status as proscribed drug in most of the countries. The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions. Several diseases like emesis, pain, inflammation, multiple sclerosis, anorexia, epilepsy, glaucoma, schizophrenia, cardiovascular disorders, cancer, obesity, metabolic syndrome related diseases, Parkinson's disease, Huntington's disease, Alzheimer's disease and Tourette's syndrome could possibly be treated by drugs modulating endocannabinoid system. Presently, cannabinoid receptor agonists like nabilone and dronabinol are used for reducing the chemotherapy induced vomiting. Sativex (cannabidiol and THC combination) is approved in the UK, Spain and New Zealand to treat spasticity due to multiple sclerosis. In US it is under investigation for cancer pain, another drug Epidiolex (cannabidiol) is also under investigation in US for childhood seizures. Rimonabant, CB1 receptor antagonist appeared as a promising anti-obesity drug during clinical trials but it also exhibited remarkable psychiatric side effect profile. Due to which the US Food and Drug Administration did not approve Rimonabant in US. It sale was also suspended across the EU in 2008. Recent discontinuation of clinical trial related to FAAH inhibitor due to occurrence of serious adverse events in the participating subjects could be discouraging for the research fraternity. Despite some mishaps in clinical trials related to drugs acting on endocannabinoid system, still lot of research is being carried out to explore and establish

  19. Endocannabinoid System: A Multi-Facet Therapeutic Target.

    PubMed

    Kaur, Rimplejeet; Ambwani, Sneha R; Singh, Surjit

    2016-01-01

    Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by man for recreational and medicinal purposes since many centuries. Study of cannabinoids was at bay for very long time and its therapeutic value could not be adequately harnessed due to its legal status as proscribed drug in most of the countries. The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions. Several diseases like emesis, pain, inflammation, multiple sclerosis, anorexia, epilepsy, glaucoma, schizophrenia, cardiovascular disorders, cancer, obesity, metabolic syndrome related diseases, Parkinson's disease, Huntington's disease, Alzheimer's disease and Tourette's syndrome could possibly be treated by drugs modulating endocannabinoid system. Presently, cannabinoid receptor agonists like nabilone and dronabinol are used for reducing the chemotherapy induced vomiting. Sativex (cannabidiol and THC combination) is approved in the UK, Spain and New Zealand to treat spasticity due to multiple sclerosis. In US it is under investigation for cancer pain, another drug Epidiolex (cannabidiol) is also under investigation in US for childhood seizures. Rimonabant, CB1 receptor antagonist appeared as a promising anti-obesity drug during clinical trials but it also exhibited remarkable psychiatric side effect profile. Due to which the US Food and Drug Administration did not approve Rimonabant in US. It sale was also suspended across the EU in 2008. Recent discontinuation of clinical trial related to FAAH inhibitor due to occurrence of serious adverse events in the participating subjects could be discouraging for the research fraternity. Despite some mishaps in clinical trials related to drugs acting on endocannabinoid system, still lot of research is being carried out to explore and establish

  20. When flexibility is not necessarily a virtue: a review of hypermobility syndromes and chronic or recurrent musculoskeletal pain in children.

    PubMed

    Cattalini, Marco; Khubchandani, Raju; Cimaz, Rolando

    2015-01-01

    Chronic or recurrent musculoskeletal pain is a common complaint in children. Among the most common causes for this problem are different conditions associated with hypermobility. Pediatricians and allied professionals should be well aware of the characteristics of the different syndromes associated with hypermobility and facilitate early recognition and appropriate management. In this review we provide information on Benign Joint Hypermobility Syndrome, Ehlers-Danlos Syndrome, Marfan Syndrome, Loeys-Dietz syndrome and Stickler syndrome, and discuss their characteristics and clinical management. PMID:26444669

  1. Do as You’re Told! Facets of Agreeableness and Early Adult Outcomes for Inner-City Boys

    PubMed Central

    Kern, Margaret L.; Duckworth, Angela L.; Urzúa, Sergio; Loeber, Rolf; Stouthamer-Loeber, Magda; Lynam, Donald R.

    2013-01-01

    With data from the middle cohort of the Pittsburgh Youth Study, a prospective longitudinal study of inner-city boys, we examined whether Big Five agreeableness facets could be reliably recovered in this sample, and whether facets predicted educational, occupational, social, and antisocial life outcomes assessed a decade later. Caregivers described their adolescent boys’ personalities using the Common California Q-Set; twelve years later, participants were interviewed and court records were obtained. Factor analyses recovered two facets: compliance and compassion. Compliance predicted more schooling and lower risk of unemployment, teenage fatherhood, and crime; compassion related to longer committed relationships. Findings highlight the value of studying personality at the facet level. PMID:24311824

  2. Mesoporous NiO crystals with dominantly exposed {110} reactive facets for ultrafast lithium storage

    PubMed Central

    Su, Dawei; Ford, Mike; Wang, Guoxiu

    2012-01-01

    Faceted crystals with exposed highly reactive planes have attracted intensive investigations for applications such as hydrogen production, enhanced catalytic activity, and electrochemical energy storage and conversion. Herein, we report the synthesis of mesoporous NiO crystals with dominantly exposed {110} reactive facets by the thermal conversion of hexagonal Ni(OH)2 nanoplatelets. When applied as anode materials in lithium-ion batteries, mesoporous NiO crystals exhibit a high reversible lithium storage capacity of 700 mAh g−1 at 1 C rate in 100 cycles and an excellent cyclability. In particular, the dominantly exposed {110} reactive facets and mesoporous nanostructure of NiO crystals lead to ultrafast lithium storage, which mimics the high power delivery of supercapacitors. PMID:23226591

  3. Rotary encoding device using polygonal mirror with diffraction gratings on each facet

    NASA Technical Reports Server (NTRS)

    Leviton, Douglas B. (Inventor)

    1993-01-01

    A device for position encoding of a rotating shaft in which a polygonal mirror having a number of facets is mounted to the shaft and a monochromatic light beam is directed towards the facets. The facets of the polygonal mirror each have a low line density diffraction grating to diffract the monochromatic light beam into a number of diffracted light beams such that a number of light spots are created on a linear array detector. An analog-to-digital converter is connected to the linear array detector for reading the position of the spots on the linear array detector means. A microprocessor with memory is connected to the analog-to-digital converter to hold and manipulate the data provided by the analog-to-digital converter on the position of the spots and to compute the position of the shaft based upon the data from the analog-to-digital converter.

  4. Using self-report assessment methods to explore facets of mindfulness.

    PubMed

    Baer, Ruth A; Smith, Gregory T; Hopkins, Jaclyn; Krietemeyer, Jennifer; Toney, Leslie

    2006-03-01

    The authors examine the facet structure of mindfulness using five recently developed mindfulness questionnaires. Two large samples of undergraduate students completed mindfulness questionnaires and measures of other constructs. Psychometric properties of the mindfulness questionnaires were examined, including internal consistency and convergent and discriminant relationships with other variables. Factor analyses of the combined pool of items from the mindfulness questionnaires suggested that collectively they contain five clear, interpretable facets of mindfulness. Hierarchical confirmatory factor analyses suggested that at least four of the identified factors are components of an overall mindfulness construct and that the factor structure of mindfulness may vary with meditation experience. Mindfulness facets were shown to be differentially correlated in expected ways with several other constructs and to have incremental validity in the prediction of psychological symptoms. Findings suggest that conceptualizing mindfulness as a multifaceted construct is helpful in understanding its components and its relationships with other variables.

  5. Faceting and coarsening dynamics in the complex Swift-Hohenberg equation.

    PubMed

    Gelens, Lendert; Knobloch, Edgar

    2009-10-01

    The complex Swift-Hohenberg equation models pattern formation arising from an oscillatory instability with a finite wave number at onset and finds applications in lasers, optical parametric oscillators, and photorefractive oscillators. We show that with real coefficients this equation exhibits two classes of localized states: localized in amplitude only or localized in both amplitude and phase. The latter are associated with phase-winding states in which the real and imaginary parts of the order parameter oscillate periodically but with a constant phase difference between them. The localized states take the form of defects connecting phase-winding states with equal and opposite phase lag, and can be stable over a wide range of parameters. The formation of these defects leads to faceting of states with initially spatially uniform phase. Depending on parameters these facets may either coarsen indefinitely, as described by a Cahn-Hilliard equation, or the coarsening ceases leading to a frozen faceted structure. PMID:19905429

  6. Charge separation in facet-engineered chalcogenide photocatalyst: a selective photocorrosion approach.

    PubMed

    Li, Naixu; Liu, Maochang; Zhou, Zhaohui; Zhou, Jiancheng; Sun, Yueming; Guo, Liejin

    2014-08-21

    Finding active sites for photocatalytic reduction and oxidation allows the mechanistic understanding of a given reaction, ensuring the rational design and fabrication of an efficient photocatalyst. Herein, using well-shaped Cu2WS4 decahedra as model photocatalysts, we demonstrated that photoinduced oxidative etching could be considered as an indication of the photooxidation reaction sites of chalcogenide photocatalyst as it only occurred on {101} facets of Cu2WS4 during photocatalytic hydrogen production. The photocatalytic reduction reaction, in contrast, was confined on its {001} facets. Based on this finding, the photocatalytic activity of Cu2WS4 decahedra could be further tailored by controlling the ratio of {001}/{101} facets. Thus, this work provides a general route to the determination of reactive sites on shaped chalcogenide photocatalysts.

  7. Management of Neglected Traumatic Bilateral Cervical Facet Dislocations Without Neurological Deficit

    PubMed Central

    Farooque, Kamran; Khatri, Kavin; Gupta, Babita; Sharma, Vijay

    2015-01-01

    Introduction: Sub axial cervical spine dislocations are common and managing these cases by closed reduction is successful in the majority of cases. However, treatment of old and neglected cases is difficult and the results may vary in terms of neurological and functional outcomes. Case Presentation: We present two cases of traumatic bilateral cervical facet dislocation with no neurological deficit (ND) who referred four months after the injury. They were managed via single stage anterior discectomy, posterior facet reduction, instrumentation, and then anterior reconstruction with bone graft and cervical plate. The patients had no ND in the postoperative period and returned to work. Discussion: Patients presenting with neck pain after a history of trauma should be evaluated thoroughly with radiographs and computed tomography. The management of old neglected facet dislocations is difficult, lengthy, and fraught with potential neurological complications; operative intervention can substantially improve the quality of life in these patients. PMID:26543838

  8. Spatial variation of luminescence from AlGaN grown by facet controlled epitaxial lateral overgrowth

    NASA Astrophysics Data System (ADS)

    Bell, A.; Liu, R.; Parasuraman, U. K.; Ponce, F. A.; Kamiyama, S.; Amano, H.; Akasaki, I.

    2004-10-01

    Interesting phenomena have been observed in the epitaxial lateral overgrowth of AlxGa1-xN alloys using facet control on serrated GaN templates. A complex microstructure is observed that involves misfit dislocation arrays that are closely related to regions with significantly large variations in composition. The dislocations are on inclined planar boundaries and result from basal-plane slip, which is allowed in this inclined facet geometry. The spatial variation of the aluminum composition in the overgrowth region is determined by cathodoluminescence spectroscopy and ranges from x =0.06to0.27, for constant growth conditions that after planarization result in a uniform composition at x =0.16. These results indicate that aluminum incorporation depends significantly on the growth direction with marked preference for facets parallel to the basal plane.

  9. On the Faceting and Linking of PROV for Earth Science Data Systems

    NASA Astrophysics Data System (ADS)

    Hua, H.; Manipon, G.; Wilson, B. D.; Tan, D.; Starch, M.

    2015-12-01

    Faceted search has yielded powerful capabilities for discovery of information by applying multiple filters to explore information. This is often more effective when the information is decomposed into faceted components that can be sliced and diced during faceted navigation. We apply this approach to the representation of PROV for Earth Science (PROV-ES) to facilitate more atomic units of provenance for discovery. Traditional bundles of PROV are then decomposed to enable finer-grain discovery of provenance. Linkages across provenance components can then be explored across seemingly disparate bundles. We will show how mappings into this provenance approach can be used to explore more data life-cycle relationships from observation to data to findings. We will also show examples of how this approach can be used to improve the discovery, access, and transparency of NASA datasets and the science data systems that were used to capture, manage, and produce the provenance information.

  10. Facet personality and surface-level diversity as team mental model antecedents: implications for implicit coordination.

    PubMed

    Fisher, David M; Bell, Suzanne T; Dierdorff, Erich C; Belohlav, James A

    2012-07-01

    Team mental models (TMMs) have received much attention as important drivers of effective team processes and performance. Less is known about the factors that give rise to these shared cognitive structures. We examined potential antecedents of TMMs, with a specific focus on team composition variables, including various facets of personality and surface-level diversity. Further, we examined implicit coordination as an important outcome of TMMs. Results suggest that team composition in terms of the cooperation facet of agreeableness and racial diversity were significantly related to team-focused TMM similarity. TMM similarity was also positively predictive of implicit coordination, which mediated the relationship between TMM similarity and team performance. Post hoc analyses revealed a significant interaction between the trust facet of agreeableness and racial diversity in predicting TMM similarity. Results are discussed in terms of facilitating the emergence of TMMs and corresponding implications for team-related human resource practices.

  11. Highly ordered self-assembled nanoscale periodic faceting in GaAs(631) homoepitaxial growth

    SciTech Connect

    Cruz-Hernandez, E.; Mendez-Garcia, V. H.; Shimomura, S.

    2012-08-13

    We report on the self-assembly of large-order-correlated nanoscale faceting on GaAs(631)A substrates grown by molecular beam epitaxy. The surface morphology of the grown samples as a function of the growth temperature and the As-beam equivalent pressure was studied using atomic force microscopy. A two-dimensional autocorrelation function analysis was performed in order to quantitatively determine the uniformity of the surface corrugation. By optimizing the growth conditions, correlated faceted areas as large as 1.7 Multiplication-Sign 1.7 {mu}m{sup 2} are obtained. The highly ordered surface corrugation discussed here provides useful insights to prepare highly ordered facet planes for the self organized growth of quantum wires.

  12. The 3 facets of regulation of herpes simplex virus gene expression: a critical inquiry

    PubMed Central

    Roizman, Bernard; Zhou, Guoying

    2015-01-01

    On entry into the body herpes simplex viruses (HSV) replicate in a series of steps that involves derepression of viral DNA activated by VP16, a virion protein, and sequential transcription of viral genes in a cascade fashion. HSV also enters into neurons in which viral DNA maintained as heterochromatin and with few exceptions viral gene expression is silenced. A third face of the interaction of HSV with its host cells takes place at the moment when the silenced viral genome in neurons is abruptly derepressed. The available data do no reveal evidence that HSV encodes different regulatory programs for each facet of its interaction with its host cells. Rather the data point to significant gaps in our knowledge of the mechanisms by which each facet is initiated and the roles of the infected cells at each facet of the interaction of viral gene products with the host cell. PMID:25771487

  13. Interferometric technique for faceted microstructure metrology using an index matching liquid

    SciTech Connect

    Purcell, Daryl; Suratkar, Amit; Davies, Angela; Farahi, Faramarz; Ottevaere, Heidi; Thienpont, Hugo

    2010-02-01

    Microstructured optical products are becoming more widespread due to advances in manufacturing. Many of these structures contain faceted surfaces with steep slopes. Adequate metrology for such surfaces is lacking. We describe an interferometric technique that combines plane wave illumination with an index matching liquid to achieve high quality, high speed measurements of such faceted microstructures. We account for refraction at the interfaces, rather than consider only optical path length changes due to the index liquid, and this significantly improves the facet angle measurement. We demonstrate the technique with the measurement of an array of micropyramids and show that our results are in good agreement with measurements taken on a contact profilometer. We also extend the technique to measure opaque microcorner cubes by implementing an intermediate replication step.

  14. Cross-cultural evidence for the two-facet structure of pride

    PubMed Central

    Shi, Yan; Chung, Joanne M.; Cheng, Joey T.; Tracy, Jessica L.; Robins, Richard W.; Chen, Xiao; Zheng, Yong

    2016-01-01

    Across six studies conducted in Mainland China and South Korea, the present research extended prior findings showing that pride is comprised of two distinct conceptual and experiential facets in the U.S.: a pro-social, achievement-oriented “authentic pride”, and an arrogant, self-aggrandizing “hubristic pride”. This same two-facet structure emerged in Chinese participants’ semantic conceptualizations of pride (Study 1), Chinese and Koreans’ dispositional tendencies to experience pride (Studies 2, 3a, and 3b), Chinese and Koreans’ momentary pride experiences (Studies 3a, 3b, and 5), and Americans’ pride experiences using descriptors derived indigenously in Korea (Study 4). Together, these studies provide the first evidence that the two-facet structure of pride generalizes to cultures with highly divergent views of pride and self-enhancement processes from North America. PMID:27158171

  15. {116} faceted anatase single-crystalline nanosheet arrays: facile synthesis and enhanced electrochemical performances

    NASA Astrophysics Data System (ADS)

    Li, Feng; Li, Xiaoning; Peng, Ranran; Zhai, Xiaofang; Yang, Shangfeng; Fu, Zhengping; Lu, Yalin

    2014-10-01

    Single-crystalline anatase TiO2 nanosheet arrays were synthesized on a transparent conductive fluorine-doped tin oxide (FTO) substrate with a unique one-step alcohol-thermal process. The nanosheets were nearly vertically grown on the FTO substrate along their <11&cmb.macr;0> zone, and they were dominated by {116} facets. The as-fabricated {116} faceted single-crystalline anatase nanosheet arrays exhibit a much higher reduction capacity and a much better electrochemical reversibility than both {001} faceted anatase single-crystalline nanosheet arrays and P25 film. The results indicate a promising application potential for the new material in the photoelectrochemical field.Single-crystalline anatase TiO2 nanosheet arrays were synthesized on a transparent conductive fluorine-doped tin oxide (FTO) substrate with a unique one-step alcohol-thermal process. The nanosheets were nearly vertically grown on the FTO substrate along their <11&cmb.macr;0> zone, and they were dominated by {116} facets. The as-fabricated {116} faceted single-crystalline anatase nanosheet arrays exhibit a much higher reduction capacity and a much better electrochemical reversibility than both {001} faceted anatase single-crystalline nanosheet arrays and P25 film. The results indicate a promising application potential for the new material in the photoelectrochemical field. Electronic supplementary information (ESI) available: Photo of the large area STNA-116, FESEM images of STNA-001 and STNA-116 with a series of growth time, the enlarged XRD pattern, the simulated SAED pattern, the reflectance spectra, the cyclic voltammograms of P25 on the FTO substrate. See DOI: 10.1039/c4nr04248d

  16. [Total temporomandibular joint prostheses].

    PubMed

    Zwetyenga, N; Amroun, S; Wajszczak, B-L; Moris, V

    2016-09-01

    The temporomandibular joint (TMJ) is probably the most complex human joint. As in all joints, its prosthetic replacement may be indicated in selected cases. Significant advances have been made in the design of TMJ prostheses during the last three decades and the indications have been clarified. The aim of our work was to make an update on the current total TMJ total joint replacement. Indications, contraindications, prosthetic components, advantages, disadvantages, reasons for failure or reoperation, virtual planning and surgical protocol have been exposed. PMID:27554487

  17. Facet effects of palladium nanocrystals for oxygen reduction in ionic liquids and for sensing applications

    NASA Astrophysics Data System (ADS)

    Tang, Yongan; Chi, Xiaowei; Zou, Shouzhong; Zeng, Xiangqun

    2016-03-01

    Palladium nanocrystals enclosed by {100} and {110} crystal facets, were successfully synthesized through an aqueous one-pot synthesis method. A new thermal annealing approach was developed for fabricating these palladium nanocrystals as a working electrode on a gas permeable membrane to study the facet effects of the oxygen reduction process in an ionic liquid, 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([Bmpy][NTf2]). Results were compared with the same processes at a conventional platinum electrode. Our study shows that the structural difference between the two facets of Pd nanocrystals has little effect on the oxygen reduction process but significantly affects the oxidation process of the superoxide. It is found that the Pd{110}/IL interface can better stabilize superoxide radicals revealed by a more positive oxidation potential compared to that of Pd{100}. In addition, the analytical characteristic of utilizing both palladium nanocrystals as electrodes for oxygen sensing is comparable with a polycrystal platinum oxygen sensor, in which Pd{110} presents the best sensitivity and lowest detection limit. Our results demonstrate the facet-dependence of oxygen reduction in an ionic liquid medium and provide the fundamental information needed to guide the applications of palladium nanocrystals in electrochemical gas sensor and fuel cell research.Palladium nanocrystals enclosed by {100} and {110} crystal facets, were successfully synthesized through an aqueous one-pot synthesis method. A new thermal annealing approach was developed for fabricating these palladium nanocrystals as a working electrode on a gas permeable membrane to study the facet effects of the oxygen reduction process in an ionic liquid, 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([Bmpy][NTf2]). Results were compared with the same processes at a conventional platinum electrode. Our study shows that the structural difference between the two facets of Pd

  18. Contemporary cybernetics and its facets of cognitive informatics and computational intelligence.

    PubMed

    Wang, Yingxu; Kinsner, Witold; Zhang, Du

    2009-08-01

    This paper explores the architecture, theoretical foundations, and paradigms of contemporary cybernetics from perspectives of cognitive informatics (CI) and computational intelligence. The modern domain and the hierarchical behavioral model of cybernetics are elaborated at the imperative, autonomic, and cognitive layers. The CI facet of cybernetics is presented, which explains how the brain may be mimicked in cybernetics via CI and neural informatics. The computational intelligence facet is described with a generic intelligence model of cybernetics. The compatibility between natural and cybernetic intelligence is analyzed. A coherent framework of contemporary cybernetics is presented toward the development of transdisciplinary theories and applications in cybernetics, CI, and computational intelligence.

  19. Multiple facets of HIV-associated renal disease

    PubMed Central

    da Silva, D.R.; Gluz, I.C.; Kurz, J.; Thomé, G.G.; Zancan, R.; Bringhenti, R.N.; Schaefer, P.G.; dos Santos, M.; Barros, E.J.G.; Veronese, F.V.

    2016-01-01

    HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model. The outcomes of chronic kidney disease (CKD) and ESRD or death were evaluated by baseline CD4 cell count. The percent distribution at initial clinical presentation was non-nephrotic proteinuria (54%), acute kidney injury (28%), nephrotic syndrome (23%), and chronic kidney disease (22%). Focal segmental glomerulosclerosis (28%), mainly the collapsing form (HIVAN), acute interstitial nephritis (AIN) (26%), and immune complex-mediated glomerulonephritis (ICGN) (25%) were the predominant renal histology. Baseline CD4 cell count ≥200 cells/mm3 was a protective factor against CKD (hazard ratio=0.997; 95%CI=0.994-0.999; P=0.012). At last follow-up, 64% of patients with baseline CD4 ≥200 cells/mm3 had eGFR >60 mL·min-1·(1.73 m2)-1 compared to the other 35% of patients who presented with CD4 <200 cells/mm3 (log rank=9.043, P=0.003). In conclusion, the main histological lesion of HIV-associated renal disease was HIVAN, followed by AIN and ICGN. These findings reinforce the need to biopsy HIV patients with kidney impairment and/or proteinuria. Baseline CD4 cell count ≥200 cells/mm3 was associated with better renal function after 2 years of follow-up. PMID:27007656

  20. Multiple facets of HIV-associated renal disease.

    PubMed

    da Silva, D R; Gluz, I C; Kurz, J; Thomé, G G; Zancan, R; Bringhenti, R N; Schaefer, P G; Dos Santos, M; Barros, E J G; Veronese, F V

    2016-01-01

    HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model. The outcomes of chronic kidney disease (CKD) and ESRD or death were evaluated by baseline CD4 cell count. The percent distribution at initial clinical presentation was non-nephrotic proteinuria (54%), acute kidney injury (28%), nephrotic syndrome (23%), and chronic kidney disease (22%). Focal segmental glomerulosclerosis (28%), mainly the collapsing form (HIVAN), acute interstitial nephritis (AIN) (26%), and immune complex-mediated glomerulonephritis (ICGN) (25%) were the predominant renal histology. Baseline CD4 cell count ≥ 200 cells/mm3 was a protective factor against CKD (hazard ratio=0.997; 95%CI=0.994-0.999; P=0.012). At last follow-up, 64% of patients with baseline CD4 ≥ 200 cells/mm3 had eGFR >60 mL·min-1·(1.73 m2)-1 compared to the other 35% of patients who presented with CD4 <200 cells/mm3 (log rank=9.043, P=0.003). In conclusion, the main histological lesion of HIV-associated renal disease was HIVAN, followed by AIN and ICGN. These findings reinforce the need to biopsy HIV patients with kidney impairment and/or proteinuria. Baseline CD4 cell count ≥ 200 cells/mm3 was associated with better renal function after 2 years of follow-up.

  1. Turner Syndrome

    MedlinePlus

    Turner syndrome is a genetic disorder that affects a girl's development. The cause is a missing or ... t work properly. Other physical features typical of Turner syndrome are Short, "webbed" neck with folds of ...

  2. LEOPARD syndrome

    MedlinePlus

    LEOPARD syndrome is a very rare inherited disorder in which there are problems with the skin, face, ... LEOPARD syndrome is inherited as an autosomal dominant trait. This means the person only needs the abnormal ...

  3. Pendred Syndrome

    MedlinePlus

    ... thyroid gland. Pendred syndrome also can affect the vestibular system, which controls balance. Some people with Pendred syndrome will show vestibular weakness when their balance is tested. However, the ...

  4. Bloom's Syndrome

    MedlinePlus

    ... Glycogen Storage Disease, Type 1A Joubert Syndrome Maple Syrup Urine Disease and DLD Mucolipidosis IV (MLIV) Nemaline ... Glycogen Storage Disease, Type 1A Joubert Syndrome Maple Syrup Urine Disease and DLD Mucolipidosis IV (MLIV) Nemaline ...

  5. Metabolic Syndrome

    MedlinePlus

    Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. These ... doctors agree on the definition or cause of metabolic syndrome. The cause might be insulin resistance. Insulin is ...

  6. Cushing's Syndrome

    MedlinePlus

    ... Cushing's syndrome, also called hypercortisolism , is a rare endocrine disorder caused by chronic exposure of the body's tissues ... removing the tumor while minimizing the chance of endocrine deficiency or long-term ... for Cushing's Syndrome Clinical Trials ...

  7. Rett Syndrome

    MedlinePlus

    Rett syndrome is a rare genetic disease that causes developmental and nervous system problems, mostly in girls. It's related to autism spectrum disorder. Babies with Rett syndrome seem to grow and develop normally at first. ...

  8. Piriformis syndrome

    MedlinePlus

    Pseudosciatica; Wallet sciatica; Hip socket neuropathy; Pelvic outlet syndrome; Low back pain - piriformis ... Sciatica is the main symptom of piriformis syndrome. Other symptoms include: Tenderness or a dull ache in ...

  9. Angelman Syndrome

    MedlinePlus

    ... causes developmental delay and neurological problems. The physician Harry Angelman first delineated the syndrome in 1965, when ... 202-534-3731 Prader-Willi Syndrome Association 8588 Potter Park Drive Suite 500 Sarasota, FL 34238 national@ ...

  10. Mechanics of Sheeting Joints

    NASA Astrophysics Data System (ADS)

    Martel, S. J.

    2015-12-01

    Physical breakdown of rock across a broad scale spectrum involves fracturing. In many areas large fractures develop near the topographic surface, with sheeting joints being among the most impressive. Sheeting joints share many geometric, textural, and kinematic features with other joints (opening-mode fractures) but differ in that they are (a) discernibly curved, (b) open near the topographic surface, and (c) form subparallel to the topographic surface. Where sheeting joints are geologically young, the surface-parallel compressive stresses are typically several MPa or greater. Sheeting joints are best developed beneath domes, ridges, and saddles; they also are reported, albeit rarely, beneath valleys or bowls. A mechanism that accounts for all these associations has been sought for more than a century: neither erosion of overburden nor high lateral compressive stresses alone suffices. Sheeting joints are not accounted for by Mohr-Coulomb shear failure criteria. Principles of linear elastic fracture mechanics, together with the mechanical effect of a curved topographic surface, do provide a basis for understanding sheeting joint growth and the pattern sheeting joints form. Compressive stresses parallel to a singly or doubly convex topographic surface induce a tensile stress perpendicular to the surface at shallow depths; in some cases this alone could overcome the weight of overburden to open sheeting joints. If regional horizontal compressive stresses, augmented by thermal stresses, are an order of magnitude or so greater than a characteristic vertical stress that scales with topographic amplitude, then topographic stress perturbations can cause sheeting joints to open near the top of a ridge. This topographic effect can be augmented by pressure within sheeting joints arising from water, ice, or salt. Water pressure could be particularly important in helping drive sheeting joints downslope beneath valleys. Once sheeting joints have formed, the rock sheets between

  11. Piriformis muscle syndrome.

    PubMed

    Kuncewicz, Elzbieta; Gajewska, Ewa; Sobieska, Magdalena; Samborski, Włodzimierz

    2006-01-01

    Sciatica is characterized by radiating pain from the sacro-lumbar region to the buttocks and down to the lower limb. The causes of sciatica usually relate to degenerative changes in the spine and lesions to the intervertebral discs. Secondary symptomatic sciatica may by caused by metastases to the vertebra, tuberculosis of the spine, tumors located inside the vertebral channel, or entrapment of the sciatic nerve in the piriformis muscle. The piriformis syndrome is primarily caused by fall injury, but other causes are possible, including pyomyositis, dystonia musculorum deformans, and fibrosis after deep injections. Secondary causes like irritation of the sacroiliac joint or lump near the sciatic notch have been described. In the general practice the so-called posttraumatic piriformis muscle syndrome is common. The right treatment can be started following a thorough investigation into the cause of symptoms. PMID:17385355

  12. Sotos syndrome.

    PubMed

    Juneja, A; Sultan, A

    2011-12-01

    Sotos syndrome is a well-defined childhood overgrowth syndrome characterized by pre- and postnatal overgrowth, developmental delay, advanced bone age, and a typical facial gestalt including macrodolichocephaly with frontal bossing, frontoparietal sparseness of hair, apparent hypertelorism, downslanting palpebral fissures, and facial flushing. This report presents a case of Sotos syndrome in a 5½-year-old child. PMID:22169837

  13. Velocardiofacial Syndrome

    ERIC Educational Resources Information Center

    Gothelf, Doron; Frisch, Amos; Michaelovsky, Elena; Weizman, Abraham; Shprintzen, Robert J.

    2009-01-01

    Velocardiofacial syndrome (VCFS), also known as DiGeorge, conotruncal anomaly face, and Cayler syndromes, is caused by a microdeletion in the long arm of Chromosome 22. We review the history of the syndrome from the first clinical reports almost half a century ago to the current intriguing molecular findings associating genes from the…

  14. Dumping Syndrome

    MedlinePlus

    ... Disease Organizations​​ (PDF, 341 KB)​​​​​ Alternate Language URL Dumping Syndrome Page Content On this page: What is ... Nutrition Points to Remember Clinical Trials What is dumping syndrome? Dumping syndrome occurs when food, especially sugar, ...

  15. Down syndrome

    MedlinePlus

    Down syndrome is a genetic condition in which a person has 47 chromosomes instead of the usual 46. ... In most cases, Down syndrome occurs when there is an extra copy of chromosome 21. This form of Down syndrome is called trisomy 21. ...

  16. Ehlers-Danlos syndrome.

    PubMed

    Taj, Farhana Tahseen; Sajjan, Vijaya V; Singh, Dolly

    2014-11-01

    Ehlers-Danlos syndrome (EDS) is a generalized disorder of one element of connective tissue manifesting clinically by fragility and hyperelasticity of the skin and joint laxity. It is a hereditary disorder, the inheritance being usually autosomal dominant with low penetrance. Autosomal recessive and X-linked recessive varieties are also known. First described by Hippocrates in 4(th) century B.C., the various clinical types with variable penetrance have been described lately. The number of cases EDS reported in the literature is very meagre. With the available information only about six publications of classic EDS in siblings had been reported in Indian literature. PMID:25506578

  17. [Ehlers-Danlos syndrome].

    PubMed

    Leganger, Julie; Søborg, Marie-Louise Kulas; Farholt, Stense; Lund, Allan Meldgaard; Rosenberg, Jacob; Burcharth, Jakob

    2016-04-25

    Ehlers-Danlos syndrome (EDS) comprises a group of diseases characterized by connective tissue fragility. The clinical symptoms primarily involve the skin, joints, blood vessels and internal organs. Diagnosing EDS is complicated because of the clinical variability, imprecise diagnostic criteria, and because physicians may lack knowledge of this rare disease. The aim of this article is to provide an overview of the clinical symptoms and to provide recommendations on diagnosis and treatment. Referring patients to one of the national centres for rare diseases is important. PMID:27136954

  18. [Autoinflammatory syndromes in childhood].

    PubMed

    Horneff, G

    2015-08-01

    Systemic autoinflammatory diseases are a group of hereditary and non-hereditary diseases of the innate immune system, characterized by inflammation with no apparent cause, recurrence at irregular intervals and manifestation on the skin, mucous membranes, joints, bone, gastrointestinal tract, blood vessels and the central nervous system (CNS). Amyloidosis and other possibly severe long-term complications are important. Advances in genetics and molecular biology have improved understanding of the pathogenesis of these diseases, including familial Mediterranean fever, mevalonate kinase deficiency syndrome, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome and improved others. The vast majority of these diseases are based on activation of the interleukin-1 (IL-1) pathway, so that inhibition of IL-1 provides a therapeutic option. Other syndromes are characterized by a granulomatous inflammation. Newer autoinflammatory diseases, such as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) and stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) are, however, driven by interferons. PMID:26238708

  19. Compound solder joints

    NASA Technical Reports Server (NTRS)

    Batista, R. I.; Simonson, R. B.

    1976-01-01

    Joining technique prevents contamination, may be used to join dissimilar metal tubes, minimizes fluid and gas entrapment, expedites repairs, and can yield joints having leakage rates less than 0.000001 standard cubic cm He/min. Components of joint are solder sleeve, two solder rings, Teflon sleeve, and tubing to be joined.

  20. Truss Slip Joint

    NASA Technical Reports Server (NTRS)

    Thomas, Frank

    1993-01-01

    Truss slip joint has few parts, strong, and assembled and disassembled easily. Designed to carry axial loads as large as 100,000 lb and to accommodate slight initial axial-displacement and angular misalignments. Joint assembled or disassembled by astronaut in space suit or, on Earth, by technician in heavy protective clothing; simple enough to be operable by robot. Modified to accommodate welding.

  1. Wedge Joints for Trusses

    NASA Technical Reports Server (NTRS)

    Wood, Kenneth E.

    1987-01-01

    Structure assembled rapidly with simple hand tools. Proposed locking wedge joints enable rapid assembly of lightweight beams, towers, scaffolds, and other truss-type structures. Lightweight structure assembled from tubular struts joined at nodes by wedge pins fitting into mating slots. Joint assembled rapidly by seating wedge pin in V-shaped slots and deforming end of strut until primary pawl engages it.

  2. Strategies for joint appointments.

    PubMed

    Royle, J; Crooks, D L

    1985-01-01

    The structure and policies governing joint appointments discussed above, are developed primarily through cooperation and collaboration between nursing service and education institutions. The joint appointee participates in the process of negotiation of salary, benefits and role responsibilities and exploration of the implications of the appointment for personal career development. Implementation and maintenance of the appointment requires the collaborative efforts of the joint appointee with both contracting agencies. Factors influencing the functioning of joint appointees have been identified and strategies to facilitate functioning presented. The joint appointee must be independent in thought and action yet adaptable to work within the boundaries of two social systems with differing values and expectations. Nursing management, peers and students can provide the support needed to overcome the frustrations and to achieve the rewards inherent in successful implementation of an exciting and innovative role. PMID:3852805

  3. [Approach to joint effusion].

    PubMed

    Henniger, M; Rehart, S

    2016-09-01

    The fundamental components of the differential diagnostics of joint effusions are the patient history and clinical examination. In the case of unclear findings, arthrosonography can provide information for the distinction between intra-articular and extra-articular pathologies. In atraumatic joint effusions inflammatory parameters in blood are determined in order to differentiate between systemic inflammatory and local inflammatory joint effusions. In the case of normal values further diagnostics are carried out using imaging. With elevated inflammatory parameters the main differential diagnoses are gouty arthritis, autoimmune joint processes and septic arthritis. When in doubt, a joint aspiration and synovial fluid analysis should be performed to rule out septic arthritis or if necessary confirmation of gouty arthritis. PMID:27562127

  4. Skeletal development of hallucal tarsometatarsal joint curvature and angulation in extant apes and modern humans.

    PubMed

    Gill, Corey M; Bredella, Miriam A; DeSilva, Jeremy M

    2015-11-01

    The medial cuneiform, namely the curvature and angulation of its distal facet with metatarsal 1, is crucial as a stabilizer in bipedal locomotion and an axis upon which the great toe medially deviates during arboreal locomotion in extant apes. Previous work has shown that facet curvature and angulation in adult dry-bone specimens can distinguish African apes from Homo, and can even distinguish among species of Gorilla. This study provides the first ontogenetic assessment of medial cuneiform curvature and angulation in juvenile (n = 68) and adult specimens (n = 102) using computed tomography in humans and extant ape specimens, including Pongo. Our data find that modern human juveniles initially have a convex and slightly medially oriented osseous surface of the developing medial cuneiform distal facet that flattens and becomes more distally oriented with age. The same pattern (though of a different magnitude) occurs developmentally in the chimpanzee medial cuneiform, but not in Gorilla or Pongo, whose medial cuneiform facet angulation remains unchanged ontogenetically. These data suggest that the medial cuneiform ossifies in a distinguishable pattern between Pongo, Gorilla, Pan, and Homo, which may in part be due to subtle differences in the loading environment at the hallucal tarsometatarsal joint-a finding that has important implications for interpreting fossil medial cuneiforms.

  5. Assessment of effectiveness of percutaneous adhesiolysis and caudal epidural injections in managing post lumbar surgery syndrome: 2-year follow-up of a randomized, controlled trial

    PubMed Central

    Manchikanti, Laxmaiah; Singh, Vijay; Cash, Kimberly A; Pampati, Vidyasagar

    2012-01-01

    Background The literature is replete with evaluations of failed surgery, illustrating a 9.5%–25% reoperation rate. Speculated causes of post lumbar surgery syndrome include epidural fibrosis, acquired stenosis, recurrent disc herniation, sacroiliac joint pain, and facet joint pain among other causes. Methods Patients (n = 120) were randomly assigned to two groups with a 2-year follow-up. Group I (control group, n = 60) received caudal epidural injections with catheterization up to S3 with local anesthetic (lidocaine 2%, 5 mL), nonparticulate betamethasone (6 mg, 1 mL), and 6 mL of 0.9% sodium chloride solution. Group II (intervention group, n = 60) received percutaneous adhesiolysis of the targeted area, with targeted delivery of lidocaine 2% (5 mL), 10% hypertonic sodium chloride solution (6 mL), and nonparticulate betamethasone (6 mg). The multiple outcome measures included the Numeric Rating Scale, the Oswestry Disability Index 2.0, employment status, and opioid intake with assessments at 3, 6, 12, 18, and 24 months posttreatment. Primary outcome was defined as 50% improvement in pain and Oswestry Disability Index scores. Results Significant improvement with at least 50% relief with pain and improvement in functional status was illustrated in 82% of patients at the 2-year follow-up in the intervention group compared to 5% in the control group receiving caudal epidural injections. The average number of procedures over a period of 2 years in Group II was 6.4 ± 2.35 with overall total relief of approximately 78 weeks out of 104 weeks. Conclusion The results of this study show significant improvement in 82% of patients over a period of 2 years with an average of six to seven procedures of 1-day percutaneous adhesiolysis in patients with failed back surgery syndrome. PMID:23293536

  6. Refeeding syndrome.

    PubMed

    Fernández López, M T; López Otero, M J; Alvarez Vázquez, P; Arias Delgado, J; Varela Correa, J J

    2009-01-01

    Refeeding syndrome is a complex syndrome that occurs as a result of reintroducing nutrition (oral, enteral or parenteral) to patients who are starved or malnourished. Patients can develop fluid-balance abnormalities, electrolyte disorders (hypophosphataemia, hypokalaemia and hypomagnesaemia), abnormal glucose metabolism and certain vitamin deficiencies. Refeeding syndrome encompasses abnormalities affecting multiple organ systems, including neurological, pulmonary, cardiac, neuromuscular and haematological functions. Pathogenic mechanisms involved in the refeeding syndrome and clinical manifestations have been reviewed. We provide suggestions for the prevention and treatment of refeeding syndrome. The most important steps are to identify patients at risk, reintroduce nutrition cautiously and correct electrolyte and vitamin deficiencies properly.

  7. Examination and Treatment of Cuboid Syndrome

    PubMed Central

    Durall, Chris J.

    2011-01-01

    Context: Cuboid syndrome is thought to be a common source of lateral midfoot pain in athletes. Evidence Acquisition: A Medline search was performed via PubMed (through June 2010) using the search terms cuboid, syndrome, subluxed, locked, fault, dropped, peroneal, lateral, plantar, and neuritis with the Boolean term AND in all possible combinations. Retrieved articles were hand searched for additional relevant references. Results: Cuboid syndrome is thought to arise from subtle disruption of the arthrokinematics or structural congruity of the calcaneocuboid joint, although the precise pathomechanic mechanism has not been elucidated. Fibroadipose synovial folds (or labra) within the calcaneocuboid joint may play a role in the cause of cuboid syndrome, but this is highly speculative. The symptoms of cuboid syndrome resemble those of a ligament sprain. Currently, there are no definitive diagnostic tests for this condition. Case reports suggest that cuboid syndrome often responds favorably to manipulation and/or external support. Conclusions: Evidence-based guidelines regarding cuboid syndrome are lacking. Consequently, the diagnosis of cuboid syndrome is often based on a constellation of signs and symptoms and a high index of suspicion. Unless contraindicated, manipulation of the cuboid should be considered as an initial treatment. PMID:23016051

  8. Violence Risk Assessment and Facet 4 of the Psychopathy Checklist: Predicting Institutional and Community Aggression in Two Forensic Samples

    ERIC Educational Resources Information Center

    Walters, Glenn D.; Heilbrun, Kirk

    2010-01-01

    The Psychopathy Checklist and Psychopathy Checklist-Revised (PCL/PCL-R) were used to predict institutional aggression and community violence in two groups of forensic patients. Results showed that Facet 4 (Antisocial) of the PCL/PCL-R or one of its parcels consistently achieved incremental validity relative to the first three facets, whereas the…

  9. Prediction of Job Satisfaction Based on Workplace Facets for Adjunct Business Faculty at Four-Year Universities

    ERIC Educational Resources Information Center

    Lewis, Vance Johnson

    2012-01-01

    The purpose of this study was to examine the job satisfaction of adjuncts in the curriculum area of business at four-year universities and to determine the roles that individual job facets play in creating overall job satisfaction. To explore which job facets and demographics predict job satisfaction for the population, participants were asked to…

  10. Dynamics of a faceted nematic-smectic-B front in thin-sample directional solidification.

    PubMed

    Börzsönyi, T; Akamatsu, S; Faivre, G

    2002-01-01

    We present an experimental study of the directional-solidification patterns of a nematic-smectic-B front. The chosen system is C4H9-(C6H10)2CN (in short, CCH4) in 12 microm-thick samples, and in the planar configuration (director parallel to the plane of the sample). The nematic-smectic-B interface presents a facet in one direction-the direction parallel to the smectic layers--and is otherwise rough and devoid of forbidden directions. We measure the Mullins-Sekerka instability threshold and establish the morphology diagram of the system as a function of the solidification rate V and the angle straight theta(0) between the facet and the isotherms. We focus on the phenomena occurring immediately above the instability threshold when straight theta(0) is neither very small nor close to 90 degrees. Under these conditions, we observe drifting shallow cells and a type of solitary wave, called "faceton," which consists essentially of an isolated macroscopic facet traveling laterally at such a velocity that its growth rate with respect to the liquid is small. Facetons may propagate either in a stationary or an oscillatory way. The detailed study of their dynamics casts light on the microscopic growth mechanisms of the facets in this system.

  11. An Examination of Blue- versus White-Collar Workers' Conceptualizations of Job Satisfaction Facets

    ERIC Educational Resources Information Center

    Hu, Xiaoxiao; Kaplan, Seth; Dalal, Reeshad S.

    2010-01-01

    This study examined the degree to which blue- versus white-collar workers differentially conceptualize various job facets, namely the work itself, co-workers, supervisors, and pay. To examine these potential differences, we conducted a series of analyses on job satisfaction ratings from two samples of university workers. Consistent with the study…

  12. Evaluating the Diagnostic Validity of a Facet-Based Formative Assessment System

    ERIC Educational Resources Information Center

    DeBarger, Angela Haydel; DiBello, Louis; Minstrell, Jim; Feng, Mingyu; Stout, William; Pellegrino, James; Haertel, Geneva; Harris, Christopher; Ructinger, Liliana

    2011-01-01

    This paper describes methods for an alignment study and psychometric analyses of a formative assessment system, Diagnoser Tools for physics. Diagnoser Tools begin with facet clusters as the interpretive framework for designing questions and instructional activities. Thus each question in the diagnostic assessments includes distractors that…

  13. Mind Your Words: Positive and Negative Items Create Method Effects on the Five Facet Mindfulness Questionnaire

    ERIC Educational Resources Information Center

    Van Dam, Nicholas T.; Hobkirk, Andrea L.; Danoff-Burg, Sharon; Earleywine, Mitch

    2012-01-01

    Mindfulness, a construct that entails moment-to-moment effort to be aware of present experiences and positive attitudinal features, has become integrated into the sciences. The Five Facet Mindfulness Questionnaire (FFMQ), one popular measure of mindfulness, exhibits different responses to positively and negatively worded items in nonmeditating…

  14. Unique relationships between facets of mindfulness and eating pathology among female smokers.

    PubMed

    Adams, Claire E; Apperson McVay, Megan; Kinsaul, Jessica; Benitez, Lindsay; Vinci, Christine; Stewart, Diana W; Copeland, Amy L

    2012-12-01

    Female smokers often have higher levels of eating disorder symptoms than non-smokers, and concerns about eating and weight might interfere with smoking cessation. Thus, it is critical to identify factors to promote healthier eating and body image in this population. Initial research suggests that specific aspects of trait mindfulness predict lower body dissatisfaction and eating disorder symptoms among non-smokers. However, these relationships are unknown among smokers. The current study examined associations between facets of trait mindfulness and eating disorder symptoms in 112 college female smokers (83% Caucasian; mean age 20 years, SD=1.69). After controlling for relevant sociodemographic variables, Describing and Nonjudging facets of mindfulness predicted lower bulimic symptoms and body dissatisfaction (ps<.05), while Acting with Awareness predicted lower bulimic and anorexic symptoms, ps<.05. Observing predicted higher anorexic symptoms, p<.05. These results suggest that specific mindfulness facets are related to lower eating disorder symptoms among smokers, whereas other facets are not associated or have a positive relationship with these symptoms. Mindfulness-based interventions focusing on Describing, Nonjudging, and Acting with Awareness may help to reduce eating pathology among female smokers, which could potentially improve smoking cessation rates in this population.

  15. Redox enzyme-mimicking activities of CeO2 nanostructures: Intrinsic influence of exposed facets

    PubMed Central

    Yang, Yushi; Mao, Zhou; Huang, Wenjie; Liu, Lihua; Li, Junli; Li, Jialiang; Wu, Qingzhi

    2016-01-01

    CeO2 nanoparticles (NPs) have been well demonstrated as an antioxidant in protecting against oxidative stress-induced cellular damages and a potential therapeutic agent for various diseases thanks to their redox enzyme-mimicking activities. The Ce3+/Ce4+ ratio and oxygen vacancies on the surface have been considered as the major originations responsible for the redox enzyme-mimicking activities of CeO2 NPs. Herein, CeO2 nanostructures (nanocubes and nanorods) exposed different facets were synthesized via a facile hydrothermal method. The characterizations by X-ray photoelectron spectroscopy, Raman spectroscopy, and UV-Vis spectroscopy show that the Ce3+/Ce4+ ratio and oxygen vacancy content on the surfaces of as-synthesized CeO2 nanostructures are nearly at the same levels. Meanwhile, the enzymatic activity measurements indicate that the redox enzyme-mimicking activities of as-synthesized CeO2 nanostructures are greatly dependent on their exposed facets. CeO2 nanocubes with exposed {100} facets exhibit a higher peroxidase but lower superoxide dismutase activity than those of the CeO2 nanorods with exposed {110} facets. Our results provide new insights into the redox enzyme-mimicking activities of CeO2 nanostructures, as well as the design and synthesis of inorganic nanomaterials-based artificial enzymes. PMID:27748403

  16. Oral Performace Scoring Using Generalizability Theory and Many-Facet Rasch Measurement: A Comparison Study

    ERIC Educational Resources Information Center

    Alkahtani, Saif F.

    2012-01-01

    The principal aim of the present study was to better guide the Quranic recitation appraisal practice by presenting an application of Generalizability theory and Many-facet Rasch Measurement Model for assessing the dependability and fit of two suggested rubrics. Recitations of 93 students were rated holistically and analytically by 3 independent…

  17. FACET: A simulation software framework for modeling complex societal processes and interactions

    SciTech Connect

    Christiansen, J. H.

    2000-06-02

    FACET, the Framework for Addressing Cooperative Extended Transactions, was developed at Argonne National Laboratory to address the need for a simulation software architecture in the style of an agent-based approach, but with sufficient robustness, expressiveness, and flexibility to be able to deal with the levels of complexity seen in real-world social situations. FACET is an object-oriented software framework for building models of complex, cooperative behaviors of agents. It can be used to implement simulation models of societal processes such as the complex interplay of participating individuals and organizations engaged in multiple concurrent transactions in pursuit of their various goals. These transactions can be patterned on, for example, clinical guidelines and procedures, business practices, government and corporate policies, etc. FACET can also address other complex behaviors such as biological life cycles or manufacturing processes. To date, for example, FACET has been applied to such areas as land management, health care delivery, avian social behavior, and interactions between natural and social processes in ancient Mesopotamia.

  18. A Faceted Taxonomy for Rating Student Bibliographies in an Online Information Literacy Game

    ERIC Educational Resources Information Center

    Leeder, Chris; Markey, Karen; Yakel, Elizabeth

    2012-01-01

    This study measured the quality of student bibliographies through creation of a faceted taxonomy flexible and fine-grained enough to encompass the variety of online sources cited by today's students. The taxonomy was developed via interviews with faculty, iterative refinement of categories and scoring, and testing on example student…

  19. Validity of Social, Moral and Emotional Facets of Self-Description Questionnaire II

    ERIC Educational Resources Information Center

    Leung, Kim Chau; Marsh, Herbert W.; Yeung, Alexander Seeshing; Abduljabbar, Adel S.

    2015-01-01

    Studies adopting a construct validity approach can be categorized into within- and between-network studies. Few studies have applied between-network approach and tested the correlations of the social (same-sex relations, opposite-sex relations, parent relations), moral (honesty-trustworthiness), and emotional (emotional stability) facets of the…

  20. Mosaic and facet structures of epitaxial MnO films on Au (110)

    NASA Astrophysics Data System (ADS)

    Meinel, K.; Huth, M.; Beyer, H.; Neddermeyer, H.; Widdra, W.

    2014-01-01

    Growth and annealing behavior of epitaxial MnO films on an Au (110)-(1 × 2) substrate have been studied by means of Auger electron spectroscopy, low energy electron diffraction, and scanning tunneling microscopy. MnO (110) films have been successfully grown by Mn evaporation in an oxygen atmosphere at room temperature with subsequent annealing to 750 K. Instead of the expected (110)-like diffraction pattern complex mosaic and facet structures are found depending on annealing conditions. The mosaics are misfit-induced and display along [001] directions a misorientation of ± 1.5°. At temperatures around 850 K, mosaics gradually vanish and simultaneously a saw-tooth-like film morphology develops which is formed by ribbons of narrow (100) and (010) MnO facets. At temperatures above 850 K the film partially dewets from the substrate, and the film transforms to three-dimensional MnO islands that have a roof-like shape where large roof sides and small end sides are composed by {100} and by {111} facets, respectively. The experiments corroborate the theoretical predicted tendency of facet formation of MnO (110) surfaces.