Bacteriophage P2 ogr and P4 delta genes act independently and are essential for P4 multiplication.

PubMed Central

Halling, C; Calendar, R

1990-01-01

Satellite bacteriophage P4 requires the products of the late genes of a helper phage such as P2 for lytic growth. Expression of the P2 late genes is positively regulated by the P2 ogr gene in a process requiring P2 DNA replication. Transactivation of P2 late gene expression by P4 requires the P4 delta gene product and works even in the absence of P2 DNA replication. We have made null mutants of the P2 ogr and P4 delta genes. In the absence of the P4 delta gene product, P4 multiplication required both the P2 ogr protein and P2 DNA replication. In the absence of the P2 ogr gene product, P4 multiplication required the P4 delta protein. In complementation experiments, we found that the P2 ogr protein was made in the absence of P2 DNA replication but could not function unless P2 DNA replicated. We produced P4 delta protein from a plasmid and found that it complemented the null P4 delta and P2 ogr mutants. Images PMID:2193911

LDEF Experiment P0006 Linear Energy Transfer Spectrum Measurement (LETSME) quick look report

NASA Technical Reports Server (NTRS)

1990-01-01

A preliminary analysis of the various passive radiation detector materials included in the P0006 LETSME experiment flown on LDEF (Long Duration Exposure Facility) is presented. It consists of four tasks: (1) readout and analysis of thermoluminescent detectors (TLD); (2) readout and analysis of fission foil/mica detectors; (3) readout and analysis of (6)LiF/CR-39 detectors; and (4) preliminary processing and readout of CR-39 and polycarbonate plastic nuclear track detectors (PNTD).

Women's preferences for obstetric care in rural Ethiopia: a population-based discrete choice experiment in a region with low rates of facility delivery.

PubMed

Kruk, M E; Paczkowski, M M; Tegegn, A; Tessema, F; Hadley, C; Asefa, M; Galea, S

2010-11-01

Delivery attended by skilled professionals is essential to reducing maternal mortality. Although the facility delivery rate in Ethiopia's rural areas is extremely low, little is known about which health system characteristics most influence women's preferences for delivery services. In this study, women's preferences for attributes of health facilities for delivery in rural Ethiopia were investigated. A population-based discrete choice experiment (DCE) was fielded in Gilgel Gibe, in southwest Ethiopia, among women with a delivery in the past 5 years. Women were asked to select a hypothetical health facility for future delivery from two facilities on a picture card. A hierarchical Bayesian procedure was used to estimate utilities associated with facility attributes: distance, type of provider, provider attitude, drugs and medical equipment, transport and cost. 1006 women completed 8045 DCE choice tasks. Among them, 93.8% had delivered their last child at home. The attributes with the greatest influence on the overall utility of a health facility for delivery were availability of drugs and equipment (mean β=3.9, p<0.01), seeing a doctor versus a health extension worker (mean β=2.1, p<0.01) and a receptive provider attitude (mean β=1.4, p<0.01). Women in rural southwest Ethiopia who have limited personal experience with facility delivery nonetheless value health facility attributes that indicate high technical quality: availability of drugs and equipment and physician providers. Well-designed policy experiments that measure the contribution of quality improvements to facility delivery rates in Ethiopia and other countries with low health service utilisation and high maternal mortality may inform national efforts to reduce maternal mortality.

33 CFR 6.01-4 - Waterfront facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Waterfront facility. 6.01-4... PROTECTION AND SECURITY OF VESSELS, HARBORS, AND WATERFRONT FACILITIES Definitions § 6.01-4 Waterfront facility. Waterfront facility. “Waterfront facility,” as used in this part, means all piers, wharves, docks...

The first target experiments on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Landen, O. L.; Glenzer, S. H.; Froula, D. H.; Dewald, E. L.; Suter, L. J.; Schneider, M. B.; Hinkel, D. E.; Fernandez, J. C.; Kline, J. L.; Goldman, S. R.; Braun, D. G.; Celliers, P. M.; Moon, S. J.; Robey, H. S.; Lanier, N. E.; Glendinning, S. G.; Blue, B. E.; Wilde, B. H.; Jones, O. S.; Schein, J.; Divol, L.; Kalantar, D. H.; Campbell, K. M.; Holder, J. P.; McDonald, J. W.; Niemann, C.; MacKinnon, A. J.; Collins, G. W.; Bradley, D. K.; Eggert, J. H.; Hicks, D. G.; Gregori, G.; Kirkwood, R. K.; Young, B. K.; Foster, J. M.; Hansen, J. F.; Perry, T. S.; Munro, D. H.; Baldis, H. A.; Grim, G. P.; Heeter, R. F.; Hegelich, M. B.; Montgomery, D. S.; Rochau, G. A.; Olson, R. E.; Turner, R. E.; Workman, J. B.; Berger, R. L.; Cohen, B. I.; Kruer, W. L.; Langdon, A. B.; Langer, S. H.; Meezan, N. B.; Rose, H. A.; Still, C. H.; Williams, E. A.; Dodd, E. S.; Edwards, M. J.; Monteil, M.-C.; Stevenson, R. M.; Thomas, B. R.; Coker, R. F.; Magelssen, G. R.; Rosen, P. A.; Stry, P. E.; Woods, D.; Weber, S. V.; Young, P. E.; Alvarez, S.; Armstrong, G.; Bahr, R.; Bourgade, J.-L.; Bower, D.; Celeste, J.; Chrisp, M.; Compton, S.; Cox, J.; Constantin, C.; Costa, R.; Duncan, J.; Ellis, A.; Emig, J.; Gautier, C.; Greenwood, A.; Griffith, R.; Holdner, F.; Holtmeier, G.; Hargrove, D.; James, T.; Kamperschroer, J.; Kimbrough, J.; Landon, M.; Lee, F. D.; Malone, R.; May, M.; Montelongo, S.; Moody, J.; Ng, E.; Nikitin, A.; Pellinen, D.; Piston, K.; Poole, M.; Rekow, V.; Rhodes, M.; Shepherd, R.; Shiromizu, S.; Voloshin, D.; Warrick, A.; Watts, P.; Weber, F.; Young, P.; Arnold, P.; Atherton, L.; Bardsley, G.; Bonanno, R.; Borger, T.; Bowers, M.; Bryant, R.; Buckman, S.; Burkhart, S.; Cooper, F.; Dixit, S. N.; Erbert, G.; Eder, D. C.; Ehrlich, R. E.; Felker, B.; Fornes, J.; Frieders, G.; Gardner, S.; Gates, C.; Gonzalez, M.; Grace, S.; Hall, T.; Haynam, C. A.; Heestand, G.; Henesian, M. A.; Hermann, M.; Hermes, G.; Huber, S.; Jancaitis, K.; Johnson, S.; Kauffman, B.; Kelleher, T.; Kohut, T.; Koniges, A. E.; Labiak, T.; Latray, D.; Lee, A.; Lund, D.; Mahavandi, S.; Manes, K. R.; Marshall, C.; McBride, J.; McCarville, T.; McGrew, L.; Menapace, J.; Mertens, E.; Murray, J.; Neumann, J.; Newton, M.; Opsahl, P.; Padilla, E.; Parham, T.; Parrish, G.; Petty, C.; Polk, M.; Powell, C.; Reinbachs, I.; Rinnert, R.; Riordan, B.; Ross, G.; Robert, V.; Tobin, M.; Sailors, S.; Saunders, R.; Schmitt, M.; Shaw, M.; Singh, M.; Spaeth, M.; Stephens, A.; Tietbohl, G.; Tuck, J.; van Wonterghem, B. M.; Vidal, R.; Wegner, P. J.; Whitman, P.; Williams, K.; Winward, K.; Work, K.; Wallace, R.; Nobile, A.; Bono, M.; Day, B.; Elliott, J.; Hatch, D.; Louis, H.; Manzenares, R.; O'Brien, D.; Papin, P.; Pierce, T.; Rivera, G.; Ruppe, J.; Sandoval, D.; Schmidt, D.; Valdez, L.; Zapata, K.; MacGowan, B. J.; Eckart, M. J.; Hsing, W. W.; Springer, P. T.; Hammel, B. A.; Moses, E. I.; Miller, G. H.

2007-08-01

A first set of shock timing, laser-plasma interaction, hohlraum energetics and hydrodynamic experiments have been performed using the first 4 beams of the National Ignition Facility (NIF), in support of indirect drive Inertial Confinement Fusion (ICF) and High Energy Density Physics (HEDP). In parallel, a robust set of optical and X-ray spectrometers, interferometer, calorimeters and imagers have been activated. The experiments have been undertaken with laser powers and energies of up to 8 TW and 17 kJ in flattop and shaped 1 9 ns pulses focused with various beam smoothing options. The experiments have demonstrated excellent agreement between measured and predicted laser-target coupling in foils and hohlraums, even when extended to a longer pulse regime unattainable at previous laser facilities, validated the predicted effects of beam smoothing on intense laser beam propagation in long scale-length plasmas and begun to test 3D codes by extending the study of laser driven hydrodynamic jets to 3D geometries.

Copper Selenidophosphates Cu4P2Se6, Cu4P3Se4, Cu4P4Se3, and CuP2Se, Featuring Zero-, One-, and Two-Dimensional Anions.

PubMed

Kuhn, Alexander; Schoop, Leslie M; Eger, Roland; Moudrakovski, Igor; Schwarzmüller, Stefan; Duppel, Viola; Kremer, Reinhard K; Oeckler, Oliver; Lotsch, Bettina V

2016-08-15

Five new compounds in the Cu/P/Se phase diagram have been synthesized, and their crystal structures have been determined. The crystal structures of these compounds comprise four previously unreported zero-, one-, and two-dimensional selenidophosphate anions containing low-valent phosphorus. In addition to two new modifications of Cu4P2Se6 featuring the well-known hexaselenidohypodiphosphate(IV) ion, there are three copper selenidophosphates with low-valent P: Cu4P3Se4 contains two different new anions, (i) a monomeric (zero-dimensional) selenidophosphate anion [P2Se4](4-) and (ii) a one-dimensional selenidophosphate anion [Formula: see text], which is related to the well-known gray-Se-like [Formula: see text] Zintl anion. Cu4P4Se3 contains one-dimensional [Formula: see text] polyanions, whereas CuP2Se contains the 2D selenidophosphate [Formula: see text] polyanion. It consists of charge-neutral CuP2Se layers separated by a van der Waals gap which is very rare for a Zintl-type phase. Hence, besides black P, CuP2Se constitutes a new possible source of 2D oxidized phosphorus containing layers for intercalation or exfoliation experiments. Additionally, the electronic structures and some fundamental physical properties of the new compounds are reported. All compounds are semiconducting with indirect band gaps of the orders of around 1 eV. The phases reported here add to the structural diversity of chalcogenido phosphates. The structural variety of this family of compounds may translate into a variety of tunable physical properties.

Euromir '95: first results from the Dustwatch-P detectors of the european space exposure facility

NASA Astrophysics Data System (ADS)

Shrine, N. R. G.; McDonnell, J. A. M.; Burchell, M. J.; Gardner, D. J.; Jolly, H. S.; Ratcliff, P. R.; Thomson, R.

A small, passive, retrievable dust detector/collector experiment (Dustwatch-P), based on thin foil and aerogel capture cells has been developed at the University of Kent by the Unit for Space Sciences & Astrophysics (USSA). It was mounted in the European Space Exposure Facility (ESEF) designed by the Institut d'Astrophysique Spatial (Orsay, France) and flown on the joint ESA/Russian Space Agency EuroMir '95 mission. The experiment sampled micrometeoroids and space debris in the immediate vicinity of a large space facility (Mir) and offers the opportunity for detailed particle characterisation by intact capture. Dustwatch-P was housed in 2 ESEF cassettes, each contained: 1849mm^2 of aluminium foil capture cells, 2.4mum and 5mum thick respectively, mounted above a pure copper plate; 8450mm^2 of 12mm thick silica aerogel (density of 0.1 g/cm^3 and pore size of approximately 0.07mum). 8650mm^2 of experiment-holder surfaces (highly polished 6061-T6 aluminium alloy) were also used for detection. The foils and experiment-holder surfaces readily give a flux measurement for comparison to previous data with chemical classification of any impactor residues. The aerogel was intended to capture, with minimal modification, incident hypervelocity particles. Dustwatch-P was exposed to the space environment when the ESEF cassettes were opened during Mir EVA's on the 20/21 October '95. The cassettes were hermetically sealed in space for return to Earth in February '96. We present the first results of post-flight analysis. A hypervelocity perforation has been found in each foil and a region of ejecta impacts indicating a large impact in the vicinity. This impact rate gives a higher flux than expected, possibly due to a debris cloud.

46 CFR 4.03-5 - Medical facility.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Medical facility. 4.03-5 Section 4.03-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Definitions § 4.03-5 Medical facility. The term medical facility means an American hospital...

46 CFR 4.03-5 - Medical facility.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Medical facility. 4.03-5 Section 4.03-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Definitions § 4.03-5 Medical facility. The term medical facility means an American hospital...

46 CFR 4.03-5 - Medical facility.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Medical facility. 4.03-5 Section 4.03-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Definitions § 4.03-5 Medical facility. The term medical facility means an American hospital...

46 CFR 4.03-5 - Medical facility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Medical facility. 4.03-5 Section 4.03-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Definitions § 4.03-5 Medical facility. The term medical facility means an American hospital...

46 CFR 4.03-5 - Medical facility.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Medical facility. 4.03-5 Section 4.03-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE CASUALTIES AND INVESTIGATIONS Definitions § 4.03-5 Medical facility. The term medical facility means an American hospital...

Life science experiments performed in space in the ISS/Kibo facility and future research plans.

PubMed

Ohnishi, Takeo

2016-08-01

Over the past several years, current techniques in molecular biology have been used to perform experiments in space, focusing on the nature and effects of space radiation. In the Japanese 'Kibo' facility in the International Space Station (ISS), the Japan Aerospace Exploration Agency (JAXA) has performed five life science experiments since 2009, and two additional experiments are currently in progress. The first life science experiment in space was the 'Rad Gene' project, which utilized two human cultured lymphoblastoid cell lines containing a mutated P53 : gene (m P53 : ) and a parental wild-type P53 : gene (wt P53 : ) respectively. Four parameters were examined: (i) detecting space radiation-induced DSBs by observing γH2AX foci; (ii) observing P53 : -dependent gene expression during space flight; (iii) observing P53 : -dependent gene expression after space flight; and (iv) observing the adaptive response in the two cell lines containing the mutated and wild type P53 : genes after exposure to space radiation. These observations were completed and have been reported, and this paper is a review of these experiments. In addition, recent new information from space-based experiments involving radiation biology is presented here. These experiments involve human cultured cells, silkworm eggs, mouse embryonic stem cells and mouse eggs in various experiments designed by other principal investigators in the ISS/Kibo. The progress of Japanese science groups involved in these space experiments together with JAXA are also discussed here. The Japanese Society for Biological Sciences in Space (JSBSS), the Utilization Committee of Space Environment Science (UCSES) and the Science Council of Japan (ACJ) have supported these new projects and new experimental facilities in ISS/Kibo. Currently, these organizations are proposing new experiments for the ISS through 2024. © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and

Understanding causal pathways within health systems policy evaluation through mediation analysis: an application to payment for performance (P4P) in Tanzania.

PubMed

Anselmi, Laura; Binyaruka, Peter; Borghi, Josephine

2017-02-02

The evaluation of payment for performance (P4P) programmes has focused mainly on understanding contributions to health service coverage, without unpacking causal mechanisms. The overall aim of the paper is to test the causal pathways through which P4P schemes may (or may not) influence maternal care outcomes. We used data from an evaluation of a P4P programme in Tanzania. Data were collected from a sample of 3000 women who delivered in the 12 months prior to interview and 200 health workers at 150 health facilities from seven intervention and four comparison districts in Tanzania in January 2012 and in February 2013. We applied causal mediation analysis using a linear structural equation model to identify direct and indirect effects of P4P on institutional delivery rates and on the uptake of two doses of an antimalarial drug during pregnancy. We first ran a series of linear difference-in-difference regression models to test the effect of P4P on potential mediators, which we then included in a linear difference-in-difference model evaluating the impact of P4P on the outcome. We tested the robustness of our results to unmeasured confounding using semi-parametric methods. P4P reduced the probability of women paying for delivery care (-4.5 percentage points) which mediates the total effect of P4P on institutional deliveries (by 48%) and on deliveries in a public health facility (by 78%). P4P reduced the stock-out rate for some essential drugs, specifically oxytocin (-36 percentage points), which mediated the total effect of P4P on institutional deliveries (by 22%) and deliveries in a public health facility (by 30%). P4P increased kindness at delivery (5 percentage points), which mediated the effect of P4P on institutional deliveries (by 48%) and on deliveries in a public health facility (by 49%). P4P increased the likelihood of supervision visits taking place within the last 90 days (18 percentage points), which mediated 15% of the total P4P effect on the uptake of

Trisomy 4p and deletion 4p- in a family having translocation, t(4p-; 12p+).

PubMed

Mortimer, J G; Chewings, W; Miethke, P; Smith, G F

1978-01-01

Chromosome studies on a newborn infant with the clinical features of 4p-syndrome revealed a 46,XY,4p-karyotype with deletion of bands distal to 4p14. Investigation of the family revealed normal chromosomes in the mother and a balanced translocation rcp(4;12) (p14;p13) in the father, the paternal grandfather and an uncle. A severely retarded and malformed aunt is a partial trismoy for the short arms of chromosome 4, with the unbalanced karyotype 45,XX,12p+. It appears that monosomy of bands 4p15 and 4p16 leads to the full clinical features of 4p-syndrome, while trisomy of this region causes disabilities consistent with the rather more variable 4p trisomy syndrome. From currently reported cases, a summary is presented of the results of pregnancies of both male and female translocation carriers.

47 CFR 4.5 - Definitions of outage, special offices and facilities, and 911 special facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... facilities, and 911 special facilities. 4.5 Section 4.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Definitions of outage, special offices and facilities, and 911 special facilities. (a) Outage is defined as a... government facilities.” 911 special facilities are addressed separately in paragraph (e) of this section. (c...

The P4 truss is moved to a workstand in the SSPF

NASA Technical Reports Server (NTRS)

2000-01-01

After its move across the Space Station Processing Facility, the International Space Station's P4 truss rests in its workstand. Part of the 10-truss, girder-like structure that will ultimately extend the length of a football field, the P4 is the second port truss segment that will attach to the first port truss segment (P1 truss). The P4 is scheduled for mission 12A in September 2002.

Life science experiments performed in space in the ISS/Kibo facility and future research plans

PubMed Central

Ohnishi, Takeo

2016-01-01

Over the past several years, current techniques in molecular biology have been used to perform experiments in space, focusing on the nature and effects of space radiation. In the Japanese ‘Kibo’ facility in the International Space Station (ISS), the Japan Aerospace Exploration Agency (JAXA) has performed five life science experiments since 2009, and two additional experiments are currently in progress. The first life science experiment in space was the ‘Rad Gene’ project, which utilized two human cultured lymphoblastoid cell lines containing a mutated p53 gene (mp53) and a parental wild-type p53 gene (wtp53) respectively. Four parameters were examined: (i) detecting space radiation–induced DSBs by observing γH2AX foci; (ii) observing p53-dependent gene expression during space flight; (iii) observing p53-dependent gene expression after space flight; and (iv) observing the adaptive response in the two cell lines containing the mutated and wild type p53 genes after exposure to space radiation. These observations were completed and have been reported, and this paper is a review of these experiments. In addition, recent new information from space-based experiments involving radiation biology is presented here. These experiments involve human cultured cells, silkworm eggs, mouse embryonic stem cells and mouse eggs in various experiments designed by other principal investigators in the ISS/Kibo. The progress of Japanese science groups involved in these space experiments together with JAXA are also discussed here. The Japanese Society for Biological Sciences in Space (JSBSS), the Utilization Committee of Space Environment Science (UCSES) and the Science Council of Japan (ACJ) have supported these new projects and new experimental facilities in ISS/Kibo. Currently, these organizations are proposing new experiments for the ISS through 2024. PMID:27130692

National facilities study. Volume 4: Space operations facilities task group

NASA Technical Reports Server (NTRS)

1994-01-01

The principal objectives of the National Facilities Study (NFS) were to: (1) determine where U.S. facilities do not meet national aerospace needs; (2) define new facilities required to make U.S. capabilities 'world class' where such improvements are in the national interest; (3) define where consolidation and phase-out of existing facilities is appropriate; and (4) develop a long-term national plan for world-class facility acquisition and shared usage. The Space Operations Facilities Task Group defined discrete tasks to accomplish the above objectives within the scope of the study. An assessment of national space operations facilities was conducted to determine the nation's capability to meet the requirements of space operations during the next 30 years. The mission model used in the study to define facility requirements is described in Volume 3. Based on this model, the major focus of the Task Group was to identify any substantive overlap or underutilization of space operations facilities and to identify any facility shortfalls that would necessitate facility upgrades or new facilities. The focus of this initial study was directed toward facility recommendations related to consolidations, closures, enhancements, and upgrades considered necessary to efficiently and effectively support the baseline requirements model. Activities related to identifying facility needs or recommendations for enhancing U.S. international competitiveness and achieving world-class capability, where appropriate, were deferred to a subsequent study phase.

First experiment on LMJ facility: pointing and synchronisation qualification

NASA Astrophysics Data System (ADS)

Henry, Olivier; Raffestin, Didier; Bretheau, Dominique; Luttmann, Michel; Graillot, Herve; Ferri, Michel; Seguineau, Frederic; Bar, Emmanuel; Patissou, Loic; Canal, Philippe; Sautarel, Franöise; Tranquille-Marques, Yves

2017-10-01

The LMJ (Laser mega Joule) facility at the CESTA site (Aquitaine, France) is a tool designed to deliver up to 1.2 MJ at 351 nm for plasma experiments. The experiment system will include 11 diagnostics: UV and X energy balances, imagers (Streak and stripe camera, CCD), spectrometers, and a Visar/pyrometer. The facility must be able to deliver, within the hour following the shot, all the results of the plasma diagnostics, alignment images and laser diagnostic measurements. These results have to be guaranteed in terms of conformity to the request and quality of measurement. The end of 2016 was devoted to the qualification of system pointing on target and synchronization within and between beams. The shots made with two chains (divided in 4 quads - 8 laser beams) have achieved 50 µm of misalignment accuracy (chain and quad channel) and a synchronization accuracy in the order of 50 ps . The performances achieved for plasma diagnostic (in the order of less 100 µm of alignment and timing accuracy less than 150 ps) comply with expectations. At the same time the first automatic sequences were tested. They allowed a shot on target every 6h:30 and in some case twice a day by reducing preparation actions, leading to a sequence of 4h:00.

41 CFR 101-4.410 - Comparable facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Comparable facilities... in Education Programs or Activities Prohibited § 101-4.410 Comparable facilities. A recipient may provide separate toilet, locker room, and shower facilities on the basis of sex, but such facilities...

The P4 truss is moved to a workstand in the SSPF

NASA Technical Reports Server (NTRS)

2000-01-01

In the Space Station Processing Facility, workers get ready to lower the International Space Station's P4 truss onto a workstand. Part of the 10-truss, girder-like structure that will ultimately extend the length of a football field, the P4 is the second port truss segment that will attach to the first port truss segment (P1 truss). The P4 is scheduled for mission 12A in September 2002.

Material Processing Facility - Skylab Experiment M512

NASA Technical Reports Server (NTRS)

1972-01-01

This chart details Skylab's Materials Processing Facility experiment (M512). This facility, located in the Multiple Docking Adapter, was developed for Skylab and accommodated 14 different experiments that were carried out during the three marned missions. The abilities to melt and mix without the contaminating effects of containers, to suppress thermal convection and buoyancy in fluids, and to take advantage of electrostatic and magnetic forces and otherwise masked by gravitation opened the way to new knowledge of material properties and processes. This beginning would ultimately lead to the production of valuable new materials for use on Earth.

Information on the Advanced Plant Experiment (APEX) Test Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis Lee

The purpose of this report provides information related to the design of the Oregon State University Advanced Plant Experiment (APEX) test facility. Information provided in this report have been pulled from the following information sources: Reference 1: R. Nourgaliev and et.al, "Summary Report on NGSAC (Next-Generation Safety Analysis Code) Development and Testing," Idaho National Laboratory, 2011. Note that this is report has not been released as an external report. Reference 2: O. Stevens, Characterization of the Advanced Plant Experiment (APEX) Passive Residual Heat Removal System Heat Exchanger, Master Thesis, June 1996. Reference 3: J. Reyes, Jr., Q. Wu, and J.more » King, Jr., Scaling Assessment for the Design of the OSU APEX-1000 Test Facility, OSU-APEX-03001 (Rev. 0), May 2003. Reference 4: J. Reyes et al, Final Report of the NRC AP600 Research Conducted at Oregon State University, NUREG/CR-6641, July 1999. Reference 5: K. Welter et al, APEX-1000 Confirmatory Testing to Support AP1000 Design Certification (non-proprietary), NUREG-1826, August 2005.« less

Shuttle Laser Technology Experiment Facility (LTEF)-to-airplane lasercom experiment: Airplane considerations

NASA Technical Reports Server (NTRS)

Kalil, Ford

1990-01-01

NASA is considering the use of various airplanes for a Shuttle Laser Technology Experiment Facility (LTEF)-to-Airplane laser communications experiment. As supporting documentation, pertinent technical details are included about the potential use of airplanes located at Ames Research Center and Wallops Flight Facility. The effects and application of orbital mechanics considerations are also presented, including slant range, azimuth, elevation, and time. The pros and cons of an airplane equipped with a side port with a bubble window versus a top port with a dome are discussed.

LOH- RadGene experiment at Cell Biology Experiment Facility (CBEF)

NASA Image and Video Library

2009-02-20

ISS018-E-034074 (20 Feb. 2009) --- Astronaut Sandra Magnus, Expedition 18 flight engineer, works with the LOH- RadGene experiment near the Cell Biology Experiment Facility (CBEF) in the Kibo laboratory of the International Space Station. This experiment investigates alterations in immature immune cells that have been exposed to cosmic radiation. The samples were placed in culture bags and launched to the ISS on the STS-126 mission. After the experiment, frozen samples will be returned to the ground on the STS-119 mission.

[Pay for performance (P4P). Long-term effects and perspectives].

PubMed

Schrappe, M; Gültekin, N

2011-02-01

After 10 years of experience and research, a wide array of results on evaluation and long-term effects of pay for performance (P4P) programs have been published. These data do not only give insight into most of the problems of implementation, but also into aspects which, in part, may attenuate the high expectations at the beginning of the discussion. P4P programs exhibit a ceiling effect, some improvements are reversed after incentives are cancelled, and improvements show opportunity costs as absent improvements for indicators, which are not object to financial incentives (in some cases for the same disease). These observations can be explained by the hypothesis that P4P programs have characteristics of fee-for-service reimbursement, if symmetric information is available for insurance and provider. P4P programs are local instruments. While integration of healthcare is considered as an important issue, they should be combined with programs and incentives which foster further vertical and horizontal integration. For Germany, further research in the implementation and effects of P4P programs is necessary.

The P4 truss is moved to a workstand in the SSPF

NASA Technical Reports Server (NTRS)

2000-01-01

In the Space Station Processing Facility, workers oversee the removal of the P4 truss from the truck that transported it from Tulsa, Okla. Part of the 10-truss, girder-like structure that will ultimately extend the length of a football field on the International Space Station, the P4 is the second port truss segment that will attach to the first port truss segment (P1 truss). The P4 is scheduled for mission 12A in September 2002.

LOH- RadGene experiment at Cell Biology Experiment Facility (CBEF)

NASA Image and Video Library

2009-02-20

ISS018-E-034555 (20 Feb. 2009) --- Astronaut Sandra Magnus, Expedition 18 flight engineer, takes a moment for a photo while working with the LOH- RadGene experiment at the Cell Biology Experiment Facility (CBEF) in the Kibo laboratory of the International Space Station. This experiment investigates genetic alterations in immature immune cells that have been exposed to cosmic radiation. The samples were placed in culture bags and launched to the ISS on the STS-126 mission. After the experiment, frozen samples will be returned to the ground on the STS-119 mission.

LOH- RadGene experiment at Cell Biology Experiment Facility (CBEF)

NASA Image and Video Library

2009-02-20

ISS018-E-034090 (20 Feb. 2009) --- Astronaut Sandra Magnus, Expedition 18 flight engineer, uses a communication system near the Cell Biology Experiment Facility (CBEF) in the Kibo laboratory of the International Space Station.

Long Duration Exposure Facility (LDEF). Mission 1 Experiments

NASA Technical Reports Server (NTRS)

Clark, L. G. (Editor); Kinard, W. H. (Editor); Carter, D. L., Jr. (Editor); Jones, J. L., Jr. (Editor)

1984-01-01

Spaceborne experiments using the space shuttle payload known as the Long Duration Exposure Facility are described. Experiments in the fields of materials, coatings, thermal systems, power and propulsion, electronic, and optics are discussed.

FPEF (Fluid Physics Experiment Facility) for the planned MS (Marangoni Surface) experiment

NASA Image and Video Library

2009-07-01

ISS020-E-016214 (1 July 2009) --- Canadian Space Agency astronaut Robert Thirsk, Expedition 20 flight engineer, prepares the Fluid Physics Experiment Facility (FPEF) for the planned Marangoni Surface experiment in the Kibo laboratory of the International Space Station.

The ISS Fluids and Combustion Facility: Experiment Accommodations Summary

NASA Technical Reports Server (NTRS)

Corban, Robert R.; Simons, Stephen N. (Technical Monitor)

2001-01-01

The International Space Station's (ISS's) Fluids and Combustion Facility (FCF) is in the process of final design and development activities to accommodate a wide range of experiments in the fields of combustion science and fluid physics. The FCF is being designed to provide potential experiments with well defined interfaces that can meet the experimenters requirements, provide the flexibility for on-orbit reconfiguration, and provide the maximum capability within the ISS resources and constraints. As a multi-disciplined facility, the FCF supports various experiments and scientific objectives, which will be developed in the future and are not completely defined at this time. Since developing experiments to be performed within FCF is a continuous process throughout the FCF's operational lifetime, each individual experiment must determine the best configuration of utilizing facility capabilities and resources with augmentation of specific experiment hardware. Configurations of potential experiments in the FCF has been on-going to better define the FCF interfaces and provide assurances that the FCF design will meet its design requirements. This paper provides a summary of ISS resources and FCF capabilities, which are available for potential ISS FCF users. Also, to better understand the utilization of the FCF a description of a various experiment layouts and associated operations in the FCF are provided.

NASDA aquatic animal experiment facilities for Space Shuttle and ISS.

PubMed

Uchida, Satoko; Masukawa, Mitsuyo; Kamigaichi, Shigeki

2002-01-01

National Space Development Agency of Japan (NASDA) has developed aquatic animal experiment facilities for NASA Space Shuttle use. Vestibular Function Experiment Unit (VFEU) was firstly designed and developed for physiological research using carp in Spacelab-J (SL-J, STS-47) mission. It was modified as Aquatic Animal Experiment Unit (AAEU) to accommodate small aquatic animals, such as medaka and newt, for second International Microgravity Laboratory (IML-2, STS-65) mission. Then, VFEU was improved to accommodate marine fish and to perform neurobiological experiment for Neurolab (STS-90) and STS-95 missions. We have also developed and used water purification system which was adapted to each facility. Based on these experiences of Space Shuttle missions, we are studying to develop advanced aquatic animal experiment facility for both Space Shuttle and International Space Station (ISS). c2002 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

9 CFR 3.4 - Outdoor housing facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.4 Outdoor housing facilities. (a) Restrictions. (1) The following categories of dogs or cats must not be kept in outdoor facilities, unless that practice is specifically approved by the attending veterinarian: (i) Dogs or cats that are not acclimated...

9 CFR 3.4 - Outdoor housing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.4 Outdoor housing facilities. (a) Restrictions. (1) The following categories of dogs or cats must not be kept in outdoor facilities, unless that practice is specifically approved by the attending veterinarian: (i) Dogs or cats that are not acclimated...

Electron excitation cross sections for the 2s(2)2p(3)4S(O) -- 2s(2)2p(3)2D(O) (forbidden) and 4S(O) -- 2s2p(4) 4P (resonance) transitions in O II

NASA Technical Reports Server (NTRS)

Zuo, M.; Smith, Steven J.; Chutjian, A.; Williams, I. D.; Tayal, S. S.; Mclaughlin, Brendan M.

1995-01-01

Experimental and theoretical excitation cross sections are reported for the first forbidden transition 4S(O) -- 2S(2)2p(3) 2D(O) (lambda-lambda 3726, 3729) and the first allowed (resonance) transition 4S(O) -- 2s2p(4) 4P(lambda-833) in O II. Use is made of electron energy loss and merged-beams methods. The electron energy range covered is 3.33 (threshold) to 15 eV for the S -- D transition, and 14.9 (threshold) to 40 eV for the S -- P transition. Care was taken to assess and minimize the metastable fraction of the O II beam. An electron mirror was designed and tested to reflect inelastically backscattered electrons into the forward direction to account for the full range of polar scattering angles. Comparisons are made between present experiments and 11-state R-matrix calculations. Calculations are also presented for the 4S(O) -- 2s(2)2p(3)2P(O) (lambda-2470) transition.

The P4 truss is moved to a workstand in the SSPF

NASA Technical Reports Server (NTRS)

2000-01-01

Suspended by an overhead crane in the Space Station Processing Facility, the International Space Station's P4 truss moves toward a workstand. Below and behind it on the floor is the Multi- Purpose Logistics Module Raffaello, another segment of the Space Station. Part of the 10-truss, girder-like structure that will ultimately extend the length of a football field, the P4 is the second port truss segment that will attach to the first port truss segment (P1 truss). The P4 is scheduled for mission 12A in September 2002.

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 4 Accounts 1 2014-01-01 2013-01-01 true Public reading facility. 81.8 Section 81.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE RECORDS PUBLIC AVAILABILITY OF GOVERNMENT ACCOUNTABILITY OFFICE RECORDS § 81.8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G...

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 4 Accounts 1 2013-01-01 2013-01-01 false Public reading facility. 81.8 Section 81.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE RECORDS PUBLIC AVAILABILITY OF GOVERNMENT ACCOUNTABILITY OFFICE RECORDS § 81.8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G...

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 4 Accounts 1 2012-01-01 2012-01-01 false Public reading facility. 81.8 Section 81.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE RECORDS PUBLIC AVAILABILITY OF GOVERNMENT ACCOUNTABILITY OFFICE RECORDS § 81.8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G...

Post-test analysis of dryout test 7B' of the W-1 Sodium Loop Safety Facility Experiment with the SABRE-2P code. [LMFBR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rose, S.D.; Dearing, J.F.

An understanding of conditions that may cause sodium boiling and boiling propagation that may lead to dryout and fuel failure is crucial in liquid-metal fast-breeder reactor safety. In this study, the SABRE-2P subchannel analysis code has been used to analyze the ultimate transient of the in-core W-1 Sodium Loop Safety Facility experiment. This code has a 3-D simple nondynamic boiling model which is able to predict the flow instability which caused dryout. In other analyses dryout has been predicted for out-of-core test bundles and so this study provides additional confirmation of the model.

Soil and crop management experiments in the Laboratory Biosphere: an analogue system for the Mars on Earth(R) facility.

PubMed

Silverstone, S; Nelson, M; Alling, A; Allen, J P

2005-01-01

During the years 2002 and 2003, three closed system experiments were carried out in the "Laboratory Biosphere" facility located in Santa Fe, New Mexico. The program involved experimentation of "Hoyt" Soy Beans, (experiment #1) USU Apogee Wheat (experiment #2) and TU-82-155 sweet potato (experiment #3) using a 5.37 m2 soil planting bed which was 30 cm deep. The soil texture, 40% clay, 31% sand and 28% silt (a clay loam), was collected from an organic farm in New Mexico to avoid chemical residues. Soil management practices involved minimal tillage, mulching, returning crop residues to the soil after each experiment and increasing soil biota by introducing worms, soil bacteria and mycorrhizae fungi. High soil pH of the original soil appeared to be a factor affecting the first two experiments. Hence, between experiments #2 and #3, the top 15 cm of the soil was amended using a mix of peat moss, green sand, humates and pumice to improve soil texture, lower soil pH and increase nutrient availability. This resulted in lowering the initial pH of 8.0-6.7 at the start of experiment #3. At the end of the experiment, the pH was 7.6. Soil nitrogen and phosphorus has been adequate, but some chlorosis was evident in the first two experiments. Aphid infestation was the only crop pest problem during the three experiments and was handled using an introduction of Hyppodamia convergens. Experimentation showed there were environmental differences even in this 1200 cubic foot ecological system facility, such as temperature and humidity gradients because of ventilation and airflow patterns which resulted in consequent variations in plant growth and yield. Additional humidifiers were added to counteract low humidity and helped optimize conditions for the sweet potato experiment. The experience and information gained from these experiments are being applied to the future design of the Mars On Earth(R) facility (Silverstone et al., Development and research program for a soil

Soil and crop management experiments in the Laboratory Biosphere: An analogue system for the Mars on Earth ® facility

NASA Astrophysics Data System (ADS)

Silverstone, S.; Nelson, M.; Alling, A.; Allen, J. P.

During the years 2002 and 2003, three closed system experiments were carried out in the "Laboratory Biosphere" facility located in Santa Fe, New Mexico. The program involved experimentation of "Hoyt" Soy Beans, (experiment #1) USU Apogee Wheat (experiment #2) and TU-82-155 sweet potato (experiment #3) using a 5.37 m 2 soil planting bed which was 30 cm deep. The soil texture, 40% clay, 31% sand and 28% silt (a clay loam), was collected from an organic farm in New Mexico to avoid chemical residues. Soil management practices involved minimal tillage, mulching, returning crop residues to the soil after each experiment and increasing soil biota by introducing worms, soil bacteria and mycorrhizae fungi. High soil pH of the original soil appeared to be a factor affecting the first two experiments. Hence, between experiments #2 and #3, the top 15 cm of the soil was amended using a mix of peat moss, green sand, humates and pumice to improve soil texture, lower soil pH and increase nutrient availability. This resulted in lowering the initial pH of 8.0-6.7 at the start of experiment #3. At the end of the experiment, the pH was 7.6. Soil nitrogen and phosphorus has been adequate, but some chlorosis was evident in the first two experiments. Aphid infestation was the only crop pest problem during the three experiments and was handled using an introduction of Hyppodamia convergens. Experimentation showed there were environmental differences even in this 1200 cubic foot ecological system facility, such as temperature and humidity gradients because of ventilation and airflow patterns which resulted in consequent variations in plant growth and yield. Additional humidifiers were added to counteract low humidity and helped optimize conditions for the sweet potato experiment. The experience and information gained from these experiments are being applied to the future design of the Mars On Earth ® facility (Silverstone et al., Development and research program for a soil

Scaling and entropy in p-median facility location along a line

NASA Astrophysics Data System (ADS)

Gastner, Michael T.

2011-09-01

The p-median problem is a common model for optimal facility location. The task is to place p facilities (e.g., warehouses or schools) in a heterogeneously populated space such that the average distance from a person's home to the nearest facility is minimized. Here we study the special case where the population lives along a line (e.g., a road or a river). If facilities are optimally placed, the length of the line segment served by a facility is inversely proportional to the square root of the population density. This scaling law is derived analytically and confirmed for concrete numerical examples of three US interstate highways and the Mississippi River. If facility locations are permitted to deviate from the optimum, the number of possible solutions increases dramatically. Using Monte Carlo simulations, we compute how scaling is affected by an increase in the average distance to the nearest facility. We find that the scaling exponents change and are most sensitive near the optimum facility distribution.

Space Station Furnace Facility. Experiment/Facility Requirements Document (E/FRD), volume 2, appendix 5

NASA Technical Reports Server (NTRS)

Kephart, Nancy

1992-01-01

The function of the Space Station Furnace Facility (SSFF) is to support materials research into the crystal growth and solidification processes of electronic and photonic materials, metals and alloys, and glasses and ceramics. To support this broad base of research requirements, the SSFF will employ a variety of furnace modules operated, regulated, and supported by a core of common subsystems. Furnace modules may be reconfigured or specifically developed to provide unique solidifcation conditions for each set of experiments. The SSFF modular approach permits the addition of new or scaled-up furnace modules to support the evolution of the facility as new science requirements are identified. The SSFF Core is of modular design to permit augmentation for enhanced capabilities. The fully integrated configuration of the SSFF will consist of three racks with the capability of supporting up to two furnace modules per rack. The initial configuration of the SSFF will consist of two of the three racks and one furnace module. This Experiment/Facility Requirements Document (E/FRD) describes the integrated facility requirements for the Space Station Freedom (SSF) Integrated Configuration-1 (IC1) mission. The IC1 SSFF will consist of two racks: the Core Rack, with the centralized subsystem equipment, and the Experiment Rack-1, with Furnace Module-1 and the distributed subsystem equipment to support the furnace.

10 CFR 4.550 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Program accessibility: Existing facilities. 4.550 Section 4.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR...) Transition plan. In the event that structural changes to facilities will be undertaken to achieve program...

10 CFR 4.550 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Program accessibility: Existing facilities. 4.550 Section 4.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR...) Transition plan. In the event that structural changes to facilities will be undertaken to achieve program...

Description of the Spacecraft Control Laboratory Experiment (SCOLE) facility

NASA Technical Reports Server (NTRS)

Williams, Jeffrey P.; Rallo, Rosemary A.

1987-01-01

A laboratory facility for the study of control laws for large flexible spacecraft is described. The facility fulfills the requirements of the Spacecraft Control Laboratory Experiment (SCOLE) design challenge for a laboratory experiment, which will allow slew maneuvers and pointing operations. The structural apparatus is described in detail sufficient for modelling purposes. The sensor and actuator types and characteristics are described so that identification and control algorithms may be designed. The control implementation computer and real-time subroutines are also described.

Description of the Spacecraft Control Laboratory Experiment (SCOLE) facility

NASA Technical Reports Server (NTRS)

Williams, Jeffrey P.; Rallo, Rosemary A.

1987-01-01

A laboratory facility for the study of control laws for large flexible spacecraft is described. The facility fulfills the requirements of the Spacecraft Control Laboratory Experiment (SCOLE) design challenge for laboratory experiments, which will allow slew maneuvers and pointing operations. The structural apparatus is described in detail sufficient for modelling purposes. The sensor and actuator types and characteristics are described so that identification and control algorithms may be designed. The control implementation computer and real-time subroutines are also described.

47 CFR 4.5 - Definitions of outage, special offices and facilities, and 911 special facilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... facilities, and 911 special facilities. 4.5 Section 4.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL DISRUPTIONS TO COMMUNICATIONS Reporting Requirements for Disruptions to Communications § 4.5... significant degradation in the ability of an end user to establish and maintain a channel of communications as...

Langley Mach 4 scramjet test facility

NASA Technical Reports Server (NTRS)

Andrews, E. H., Jr.; Torrence, M. G.; Anderson, G. Y.; Northam, G. B.; Mackley, E. A.

1985-01-01

An engine test facility was constructed at the NASA Langley Research Center in support of a supersonic combustion ramjet (scramjet) technology development program. Hydrogen combustion in air with oxygen replenishment provides simulated air at Mach 4 flight velocity, pressure, and true total temperature for an altitude range from 57,000 to 86,000 feet. A facility nozzle with a 13 in square exit produces a Mach 3.5 free jet flow for engine propulsion tests. The facility is described and calibration results are presented which demonstrate the suitability of the test flow for conducting scramjet engine research.

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

14 CFR 135.97 - Aircraft and facilities for recent flight experience.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft and facilities for recent flight experience. 135.97 Section 135.97 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Flight Operations § 135.97 Aircraft and facilities for recent flight experience. Each certificate holder...

The Participative Design of an Endoscopy Facility using Lean 3P

PubMed Central

Smith, Iain

2016-01-01

In the UK, bowel cancer is the second largest cancer killer. Diagnosing people earlier can save lives but demand for endoscopies is increasing and this can put pressure on waiting times. To address this challenge, an endoscopy unit in North East England decided to improve their facilities to increase capacity and create environments that improve the experience of users. This presented a significant opportunity for step change improvement but also a problem in terms of creating designs that meet user requirements whilst addressing structural or space constraints. The Lean design process known as ‘3P' (standing for the production preparation process) was utilised as a participative design strategy to engage stakeholders in the design of the new department. This involved a time-out workshop (or 3P event) in which Lean and participative design tools were utilised to create an innovative design based on ‘point of delivery' (POD) principles. The team created a design that demonstrated an increase in treatment room capacity by 25% and bed capacity by 70% whilst reducing travel distance for patients by 25.8% and staff by 27.1%. This was achieved with an increase in available space of only 13%. The Lean 3P method provided a structured approach for corporate and clinical staff to work together with patient representatives as cross-functional teams. This participative approach facilitated communication and learning between stakeholders about care processes and personal preferences. Lean 3P therefore appears to be a promising approach to improving the healthcare facilities design process to meet user requirements. PMID:27493744

Technicians monitor USMP-4 experiments being prepared for flight on STS-87 in the SSPF

NASA Technical Reports Server (NTRS)

1997-01-01

Technicians are monitoring experiments on the United States Microgravity Payload-4 (USMP-4) in preparation for its scheduled launch aboard STS-87 on Nov. 19 from Kennedy Space Center (KSC). USMP-4 experiments are prepared in the Space Station Processing Facility at KSC. The large white vertical cylinder in the center of the photo is the Advanced Automated Directional Solidification Furnace (AADSF), which is a sophisticated materials science facility used for studying a common method of processing semiconductor crystals called directional solidification. The white horizontal tube to the right is the Isothermal Dendritic Growth Experiment (IDGE), which will be used to study the dendritic solidification of molten materials in the microgravity environment.

Facile Fabrication of Composite Membranes with Dual Thermo- and pH-Responsive Characteristics.

PubMed

Ma, Bing; Ju, Xiao-Jie; Luo, Feng; Liu, Yu-Qiong; Wang, Yuan; Liu, Zhuang; Wang, Wei; Xie, Rui; Chu, Liang-Yin

2017-04-26

Facile fabrication of novel functional membranes with excellent dual thermo- and pH-responsive characteristics has been achieved by simply designing dual-layer composite membranes. pH-Responsive poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP) block copolymers and polystyrene blended with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) nanogels are respectively used to construct the top layer and bottom layer of composite membranes. The stretching/coiling conformation changes of the P4VP chains around the pK a (∼3.5-4.5) provide the composite membranes with extraordinary pH-responsive characteristics, and the volume phase transitions of PNIPAM nanogels at the pore/matrix interfaces in the bottom layer around the volume phase transition temperature (VPTT, ∼33 °C) provide the composite membranes with great thermoresponsive characteristics. The microstructures, permeability performances, and dual stimuli-responsive characteristics can be well tuned by adjusting the content of PNIPAM nanogels and the thickness of the PS-b-P4VP top layer. The water fluxes of the composite membranes can be changed in order of magnitude by changing the environment temperature and pH, and the dual thermo- and pH-responsive permeation performances of the composite membranes are satisfactorily reversible and reproducible. The membrane fabrication strategy in this work provides valuable guidance for further development of dual stimuli-responsive membranes or even multi stimuli-responsive membranes.

Differences in Experiences With Care Between Homeless and Nonhomeless Patients in Veterans Affairs Facilities With Tailored and Nontailored Primary Care Teams.

PubMed

Jones, Audrey L; Hausmann, Leslie R M; Kertesz, Stefan; Suo, Ying; Cashy, John P; Mor, Maria K; Schaefer, James H; Gundlapalli, Adi V; Gordon, Adam J

2018-05-12

Homeless patients describe poor experiences with primary care. In 2012, the Veterans Health Administration (VHA) implemented homeless-tailored primary care teams (Homeless Patient Aligned Care Team, HPACTs) that could improve the primary care experience for homeless patients. To assess differences in primary care experiences between homeless and nonhomeless Veterans receiving care in VHA facilities that had HPACTs available (HPACT facilities) and in VHA facilities lacking HPACTs (non-HPACT facilities). We used multivariable multinomial regressions to estimate homeless versus nonhomeless patient differences in primary care experiences (categorized as negative/moderate/positive) reported on a national VHA survey. We compared the homeless versus nonhomeless risk differences (RDs) in reporting negative or positive experiences in 25 HPACT facilities versus 485 non-HPACT facilities. Survey respondents from non-HPACT facilities (homeless: n=10,148; nonhomeless: n=309,779) and HPACT facilities (homeless: n=2022; nonhomeless: n=20,941). Negative and positive experiences with access, communication, office staff, provider rating, comprehensiveness, coordination, shared decision-making, and self-management support. In non-HPACT facilities, homeless patients reported more negative and fewer positive experiences than nonhomeless patients. However, these patterns of homeless versus nonhomeless differences were reversed in HPACT facilities for the domains of communication (positive experience RDs in non-HPACT versus HPACT facilities=-2.0 and 2.0, respectively); comprehensiveness (negative RDs=2.1 and -2.3), shared decision-making (negative RDs=1.2 and -1.8), and self-management support (negative RDs=0.1 and -4.5; positive RDs=0.5 and 8.0). VHA facilities with HPACT programs appear to offer a better primary care experience for homeless versus nonhomeless Veterans, reversing the pattern of relatively poor primary care experiences often associated with homelessness.

E-4 Test Facility Design Status

NASA Technical Reports Server (NTRS)

Ryan, Harry; Canady, Randy; Sewell, Dale; Rahman, Shamim; Gilbrech, Rick

2001-01-01

Combined-cycle propulsion technology is a strong candidate for meeting NASA space transportation goals. Extensive ground testing of integrated air-breathing/rocket system (e.g., components, subsystems and engine systems) across all propulsion operational modes (e.g., ramjet, scramjet) will be needed to demonstrate this propulsion technology. Ground testing will occur at various test centers based on each center's expertise. Testing at the NASA John C. Stennis Space Center will be primarily concentrated on combined-cycle power pack and engine systems at sea level conditions at a dedicated test facility, E-4. This paper highlights the status of the SSC E-4 test Facility design.

The WIND-HAARP-HIPAS Interferometer Experiment

DTIC Science & Technology

1999-04-22

Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6750--99-8349 The WIND- HAARP -HIPAS Interferometer Experiment P. RODRIGUEZ AND M. J...1999 3. REPORT TYPE AND DATES COVERED Interim Report 4. TITLE AND SUBTITLE The WIND- HAARP -HIPAS Interferometer Experiment 5. FUNDING NUMBERS JO...frequency transmitting facilities in a bistatic, interferometer mode. The HAARP and HIPAS facilities in Alaska radiated at 4525 kHz with total combined

Capsule Shimming Developments for National Ignition Facility (NIF) Hohlraum Asymmetry Experiments

DOE PAGES

Rice, Neal G.; Vu, M.; Kong, C.; ...

2017-12-20

Capsule drive in National Ignition Facility (NIF) indirect drive implosions is generated by x-ray illumination from cylindrical hohlraums. The cylindrical hohlraum geometry is axially symmetric but not spherically symmetric causing capsule-fuel drive asymmetries. We hypothesize that fabricating capsules asymmetric in wall thickness (shimmed) may compensate for drive asymmetries and improve implosion symmetry. Simulations suggest that for high compression implosions Legendre mode P 4 hohlraum flux asymmetries are the most detrimental to implosion performance. General Atomics has developed a diamond turning method to form a GDP capsule outer surface to a Legendre mode P 4 profile. The P 4 shape requiresmore » full capsule surface coverage. Thus, in order to avoid tool-lathe interference flipping the capsule part way through the machining process is required. This flipping process risks misalignment of the capsule causing a vertical step feature on the capsule surface. Recent trials have proven this step feature height can be minimized to ~0.25 µm.« less

NASDA life science experiment facilities for ISS

NASA Astrophysics Data System (ADS)

Tanigaki, F.; Masuda, D.; Yano, S.; Fujimoto, N.; Kamigaichi, S.

National Space Development Agency of Japan (NASDA) has been developing various experiment facilities to conduct space biology researches in KIBO (JEM). The Cell Biology Experiment Facility (CBEF) and the Clean Bench (CB) are installed into JEM Life Science Rack. The Biological Experiment Units (BEU) are operated in the CBEF and the CB for many kinds of experiments on cells, tissues, plants, microorganisms, or small animals. It is possible for all researchers to use these facilities under the system of the International Announcement of Opportunity. The CBEF is a CO2 incubator to provide a controlled environment (temperature, humidity, and CO2 concentration), in which a rotating table is equipped to make variable gravity (0-2g) for reference experiments. The containers called "Canisters" can be used to install the BEU in the CBEF. The CBEF supplies power, command, sensor, and video interfaces for the BEU through the utility connectors of Canisters. The BEU is a multiuser system consisting of chambers and control segments. It is operated by pre-set programs and by commands from the ground. NASDA is currently developing three types of the BEU: the Plant Experiment Unit (PEU) for plant life cycle observations and the Cell Experiment Unit (CEU1&2) for cell culture experiments. The PEU has an automated watering system with a water sensor, an LED matrix as a light source, and a CCD camera to observe the plant growth. The CEUs have culture chambers and an automated cultural medium exchange system. Engineering models of the PEU and CEU1 have been accomplished. The preliminary design of CEU2 is in progress. The design of the BEU will be modified to meet science requirements of each experiment. The CB provides a closed aseptic work-space (Operation Chamber) with gloves for experiment operations. Samples and the BEU can be manually handled in the CB. The CB has an air lock (Disinfection Chamber) to prevent contamination, and HEPA filters to make class-100-equivalent clean air

Experiment/facility requirements document for the Space Station Furnace Facility. Section 1: Integrated configuration

NASA Astrophysics Data System (ADS)

1992-05-01

The function of the Space Station Furnace Facility (SSFF) is to support materials research into the crystal growth and solidification processes of electronic and photonic materials, metals and alloys, and glasses and ceramics. To support this broad base of research requirements, the SSFF will employ a variety of furnace modules which will be operated, regulated, and supported by a core of common subsystems. Furnace modules may be reconfigured or specifically developed to provide unique solidification conditions for each set of experiments. The SSFF modular approach permits the addition of new or scaled-up furnace modules to support the evolution of the facility as new science requirements are identified. The SSFF Core is of modular design to permit augmentation for enhanced capabilities. The fully integrated configuration of the SSFF will consist of three racks with the capability of supporting up to two furnace modules per rack. The initial configuration of the SSFF will consist of two of the three racks and one furnace module. This Experiment/Facility Requirements Document (E/FRD) describes the integrated facility requirements for the Space Station Freedom (SSF) Integrated Configuration-1 (IC1) mission. The IC1 SSFF will consist of two racks: the Core Rack, with the centralized subsystem equipment; and the Experiment Rack-1, with Furnace Module-1 and the distributed subsystem equipment to support the furnace. The SSFF support functions are provided by the following Core subsystems: power conditioning and distribution subsystem (SSFF PCDS); data management subsystem (SSFF DMS); thermal control Subsystem (SSFF TCS); gas distribution subsystem (SSFF GDS); and mechanical structures subsystem (SSFF MSS).

Experiment/facility requirements document for the Space Station Furnace Facility. Section 1: Integrated configuration

NASA Technical Reports Server (NTRS)

1992-01-01

The function of the Space Station Furnace Facility (SSFF) is to support materials research into the crystal growth and solidification processes of electronic and photonic materials, metals and alloys, and glasses and ceramics. To support this broad base of research requirements, the SSFF will employ a variety of furnace modules which will be operated, regulated, and supported by a core of common subsystems. Furnace modules may be reconfigured or specifically developed to provide unique solidification conditions for each set of experiments. The SSFF modular approach permits the addition of new or scaled-up furnace modules to support the evolution of the facility as new science requirements are identified. The SSFF Core is of modular design to permit augmentation for enhanced capabilities. The fully integrated configuration of the SSFF will consist of three racks with the capability of supporting up to two furnace modules per rack. The initial configuration of the SSFF will consist of two of the three racks and one furnace module. This Experiment/Facility Requirements Document (E/FRD) describes the integrated facility requirements for the Space Station Freedom (SSF) Integrated Configuration-1 (IC1) mission. The IC1 SSFF will consist of two racks: the Core Rack, with the centralized subsystem equipment; and the Experiment Rack-1, with Furnace Module-1 and the distributed subsystem equipment to support the furnace. The SSFF support functions are provided by the following Core subsystems: power conditioning and distribution subsystem (SSFF PCDS); data management subsystem (SSFF DMS); thermal control Subsystem (SSFF TCS); gas distribution subsystem (SSFF GDS); and mechanical structures subsystem (SSFF MSS).

Harold P. Geerdes on Musical Facility Design.

ERIC Educational Resources Information Center

Wagner, Michael

1996-01-01

Presents an interview with Dr. Harold P. Geerdes, world-renowned music facility planner, acoustician, and music professor. Dr. Geerdes discusses the different characteristics of rehearsal spaces and concert halls as well as the importance of interior materials and design. He also provides some easy and inexpensive tips for schools. (MJP)

Onboard experiment data support facility. Task 2 report: Definition of onboard processing requirements

NASA Technical Reports Server (NTRS)

1976-01-01

The onboard experiment data support facility (OEDSF) will provide data processing support to various experiment payloads on board the space shuttle. The OEDSF study will define the conceptual design and generate specifications for an OEDSF which will meet the following objectives: (1) provide a cost-effective approach to end-to-end processing requirements, (2) service multiple disciplines (3) satisfy user needs, (4) reduce the amount and improve the quality of data collected, stored and processed, and (5) embody growth capacity.

KENNEDY SPACE CENTER, FLA. - STS-115 Mission Specialist Heidemarie Stefanyshyn-Piper talks to workers in the Space Station Processing Facility. She and other crew members are at KSC for hardware familiarization. The mission will deliver the second port truss segment, the P3/P4 Truss, to attach to the first port truss segment, the P1 Truss, as well as deploy solar array sets 2A and 4A.. The crew is scheduled to activate and check out the Solar Alpha Rotary Joint (SARJ) and deploy the P4 Truss radiator.

NASA Image and Video Library

2003-07-18

KENNEDY SPACE CENTER, FLA. - STS-115 Mission Specialist Heidemarie Stefanyshyn-Piper talks to workers in the Space Station Processing Facility. She and other crew members are at KSC for hardware familiarization. The mission will deliver the second port truss segment, the P3/P4 Truss, to attach to the first port truss segment, the P1 Truss, as well as deploy solar array sets 2A and 4A.. The crew is scheduled to activate and check out the Solar Alpha Rotary Joint (SARJ) and deploy the P4 Truss radiator.

Posttest examination of Sodium Loop Safety Facility experiments. [LMFBR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holland, J.W.

In-reactor, safety experiments performed in the Sodium Loop Safety Facility (SLSF) rely on comprehensive posttest examinations (PTE) to characterize the postirradiation condition of the cladding, fuel, and other test-subassembly components. PTE information and on-line instrumentation data, are analyzed to identify the sequence of events and the severity of the accident for each experiment. Following in-reactor experimentation, the SLSF loop and test assembly are transported to the Hot Fuel Examination Facility (HFEF) for initial disassembly. Goals of the HFEF-phase of the PTE are to retrieve the fuel bundle by dismantling the loop and withdrawing the test assembly, to assess the macro-conditionmore » of the fuel bundle by nondestructive examination techniques, and to prepare the fuel bundle for shipment to the Alpha-Gamma Hot Cell Facility (AGHCF) at Argonne National Laboratory.« less

9 CFR 390.4 - Facilities for inspection and copying.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Facilities for inspection and copying. 390.4 Section 390.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.4 Facilities for...

9 CFR 390.4 - Facilities for inspection and copying.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Facilities for inspection and copying. 390.4 Section 390.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.4 Facilities for...

9 CFR 390.4 - Facilities for inspection and copying.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Facilities for inspection and copying. 390.4 Section 390.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.4 Facilities for...

9 CFR 390.4 - Facilities for inspection and copying.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Facilities for inspection and copying. 390.4 Section 390.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS FREEDOM OF INFORMATION AND PUBLIC INFORMATION § 390.4 Facilities for...

Facile synthesis of magnetic Fe3O4/graphene composites for enhanced U(VI) sorption

NASA Astrophysics Data System (ADS)

Zhao, Donglin; Zhu, Hongyu; Wu, Changnian; Feng, Shaojie; Alsaedi, Ahmed; Hayat, Tasawar; Chen, Changlun

2018-06-01

A novel magnetic Fe3O4/graphene composite (FGC) was fabricated by a facile one-step reaction route and shown to be effective for sorbing U(VI) from aqueous solution. The structure, properties and application of the prepared FGC composite were well evaluated. The high saturation magnetization (45.6 emu/g) made FGC easier to be separated from the media within several seconds under an external magnetic. Effects of different ambient conditions (i.e., pH and ionic strength, contact time, temperatures) on sorption behaviors of U(VI) on FGC were carried out by batch experiments. According to the calculation of Langmuir model, the maximum sorption capacity of U(VI) on the FGC at pH 5.5 and 298 K was 176.47 mg/g. The sorption was correlated with the effects of pH, contact time, and temperature. X-ray photoelectron spectroscopy analysis revealed that U(VI) was sorbed on FGC via oxygen-containing functional groups. This work demonstrated that FGC could be recycled and used as an effective recyclable sorbent for sorption of U(VI).

Status and Planned Experiments of the Hiradmat Pulsed Beam Material Test Facility at CERN SPS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charitonidis, Nikolaos; Efthymiopoulos, Ilias; Fabich, Adrian

2015-06-01

HiRadMat (High Irradiation to Materials) is a facility at CERN designed to provide high-intensity pulsed beams to an irradiation area where material samples as well as accelerator component assemblies (e.g. vacuum windows, shock tests on high power targets, collimators) can be tested. The beam parameters (SPS 440 GeV protons with a pulse energy of up to 3.4 MJ, or alternatively lead/argon ions at the proton equivalent energy) can be tuned to match the needs of each experiment. It is a test area designed to perform single pulse experiments to evaluate the effect of high-intensity pulsed beams on materials in amore » dedicated environment, excluding long-time irradiation studies. The facility is designed for a maximum number of 1016 protons per year, in order to limit the activation of the irradiated samples to acceptable levels for human intervention. This paper will demonstrate the possibilities for research using this facility and go through examples of upcoming experiments scheduled in the beam period 2015/2016.« less

Technicians monitor USMP-4 experiments being prepared for flight on STS-87 in the SSPF

NASA Technical Reports Server (NTRS)

1997-01-01

Technicians are monitoring experiments on the United States Microgravity Payload-4 (USMP-4) in preparation for its scheduled launch aboard STS-87 on Nov. 19 from Kennedy Space Center (KSC). USMP-4 experiments are prepared in the Space Station Processing Facility at KSC. The large white vertical cylinder at the right of the photo is the Advanced Automated Directional Solidification Furnace (AADSF ), which is a sophisticated materials science facility used for studying a common method of processing semiconductor crystals called directional solidification. The technician in the middle of the photo is leaning over MEPHISTO, a cooperative American-French investigation of the fundamentals of crystal growth.

A survey of experiments and experimental facilities for active control of flexible structures

NASA Technical Reports Server (NTRS)

Sparks, Dean W., Jr.; Horner, Garnett C.; Juang, Jer-Nan; Klose, Gerhard

1989-01-01

A brief survey of large space structure control related experiments and facilities was presented. This survey covered experiments performed before and up to 1982, and those of the present period (1982-...). Finally, the future planned experiments and facilities in support of the control-structure interaction (CSI) program were reported. It was stated that new, improved ground test facilities are needed to verify the new CSI design techniques that will allow future space structures to perform planned NASA missions.

Facile formation of 2D Co2P@Co3O4 microsheets through in-situ toptactic conversion and surface corrosion: Bifunctional electrocatalysts towards overall water splitting

NASA Astrophysics Data System (ADS)

Yao, Lihua; Zhang, Nan; Wang, Yin; Ni, Yuanman; Yan, Dongpeng; Hu, Changwen

2018-01-01

Exploring efficient non-precious electrocatalysts for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is crucial for many renewable energy conversion processes. In this work, we report that 2D Co2P@Co3O4 microsheets can be prepared through an in-situ toptactic conversion from single-crystal β-Co(OH)2 microplatelets, associated with a surface phosphatization and corrosion process. The resultant Co2P@Co3O4 2D hybrid materials can further serve as self-supported bifunctional catalytic electrodes to drive the overall water splitting for HER and OER simultaneously, with low overpotentials and high long-term stability. Furthermore, a water electrolyzer based on Co2P@Co3O4 hybrid as both anode and cathode is fabricated, which achieves 10 mA cm-2 current at only 1.57 V during water splitting process. Therefore, this work provides a facile strategy to obtain 2D Co2P-based micro/nanostructures, which act as low-cost and highly active electrocatalysts towards overall water splitting application.

10 CFR 4.127 - Existing facilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Existing facilities. 4.127 Section 4.127 Energy NUCLEAR... the effective date of this subpart, but in any event, as expeditiously as possible. (d) Transition... paragraph (a) of this section, a recipient shall develop a transition plan setting forth the steps necessary...

10 CFR 4.127 - Existing facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Existing facilities. 4.127 Section 4.127 Energy NUCLEAR... the effective date of this subpart, but in any event, as expeditiously as possible. (d) Transition... paragraph (a) of this section, a recipient shall develop a transition plan setting forth the steps necessary...

10 CFR 4.127 - Existing facilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Existing facilities. 4.127 Section 4.127 Energy NUCLEAR... the effective date of this subpart, but in any event, as expeditiously as possible. (d) Transition... paragraph (a) of this section, a recipient shall develop a transition plan setting forth the steps necessary...

10 CFR 4.127 - Existing facilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Existing facilities. 4.127 Section 4.127 Energy NUCLEAR... the effective date of this subpart, but in any event, as expeditiously as possible. (d) Transition... paragraph (a) of this section, a recipient shall develop a transition plan setting forth the steps necessary...

Using pay for performance incentives (P4P) to improve management of suspected malaria fevers in rural Kenya: a cluster randomized controlled trial.

PubMed

Menya, Diana; Platt, Alyssa; Manji, Imran; Sang, Edna; Wafula, Rebeccah; Ren, Jing; Cheruiyot, Olympia; Armstrong, Janice; Neelon, Brian; O'Meara, Wendy Prudhomme

2015-10-16

Inappropriate treatment of non-malaria fevers with artemisinin-based combination therapies (ACTs) is a growing concern, particularly in light of emerging artemisinin resistance, but it is a behavior that has proven difficult to change. Pay for performance (P4P) programs have generated interest as a mechanism to improve health service delivery and accountability in resource-constrained health systems. However, there has been little experimental evidence to establish the effectiveness of P4P in developing countries. We tested a P4P strategy that emphasized parasitological diagnosis and appropriate treatment of suspected malaria, in particular reduction of unnecessary consumption of ACTs. A random sample of 18 health centers was selected and received a refresher workshop on malaria case management. Pre-intervention baseline data was collected from August to September 2012. Facilities were subsequently randomized to either the comparison (n = 9) or intervention arm (n = 9). Between October 2012 and November 2013, facilities in the intervention arm received quarterly incentive payments based on seven performance indicators. Incentives were for use by facilities rather than as payments to individual providers. All non-pregnant patients older than 1 year of age who presented to a participating facility and received either a malaria test or artemether-lumefantrine (AL) were eligible to be included in the analysis. Our primary outcome was prescription of AL to patients with a negative malaria diagnostic test (n = 11,953). Our secondary outcomes were prescription of AL to patients with laboratory-confirmed malaria (n = 2,993) and prescription of AL to patients without a malaria diagnostic test (analyzed at the cluster level, n = 178 facility-months). In the final quarter of the intervention period, the proportion of malaria-negative patients in the intervention arm who received AL was lower than in the comparison arm (7.3% versus 10.9%). The improvement

Analysis of the OPERA 15-pin experiment with SABRE-2P. [LMFBR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rose, S.D.; Carbajo, J.J.

The OPERA (Out-of-Pile Expulsion and Reentry Apparatus) experiment simulates the initial phase of a pump coastdown without scram of a liquid-metal fast breeder reactor, specifically the Fast Flux Test Facility. The test section is a 15-pin 60/sup 0/ triangular sector designed to simulate a full-size 61-pin hexagonal bundle. A previous study indicates this to be an adequate simulation. In this paper, experimental results from the OPERA 15-pin experiment performed at ANL in 1982 are compared to analytical calculations obtained with the SABRE-2P code at ORNL.

When incentives work too well: locally implemented pay for performance (P4P) and adverse sanctions towards home birth in Tanzania - a qualitative study

PubMed Central

2014-01-01

Background Despite limited evidence of its effectiveness, performance-based payments (P4P) are seen by leading policymakers as a potential solution to the slow progress in reaching Millennium Development Goal 5: improved maternal health. This paper offers insights into two of the aspects that are lacking in the current literature on P4P, namely what strategies health workers employ to reach set targets, and how the intervention plays out when implemented by local government as part of a national programme that does not receive donor funding. Methods A total of 28 in-depth interviews (IDIs) with 25 individuals were conducted in Mvomero district over a period of 15 months in 2010 and 2011, both before and after P4P payments. Seven facilities, including six dispensaries and one health centre, were covered. Informants included 17 nurses, three clinical officers, two medical attendants, one lab technician and two district health administrators. Results Health workers reported a number of strategies to increase the number of deliveries at their facility, including health education and cooperation with traditional health providers. The staff at all facilities also reported that they had told the women that they would be sanctioned if they gave birth at home, such as being fined or denied clinical cards and/or vaccinations for their babies. There is a great uncertainty in relation to the potential health impacts of the behavioural changes that have come with P4P, as the reported strategies may increase the numbers, but not necessarily the quality. Contrary to the design of the P4P programme, payments were not based on performance. We argue that this was due in part to a lack of resources within the District Administration, and in part as a result of egalitarian fairness principles. Conclusions Our results suggest that particular attention should be paid to adverse effects when using external rewards for improved health outcomes, and secondly, that P4P may take on a

Facile solvothermal synthesis of mesostructured Fe3O4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents.

PubMed

Zhao, Guanghui; Wang, Jianzhi; Peng, Xiaomen; Li, Yanfeng; Yuan, Xuemei; Ma, Yingxia

2014-02-01

We report a facile fabrication of a host-metal-guest coordination-bonding system in a mesostructured Fe3O4/chitosan nanoparticle that can act as a pH-responsive drug-delivery system. The mesostructured Fe3O4/chitosan was synthesized by a solvothermal approach with iron(III) chloride hexahydrate as a precursor, ethylene glycol as a reducing agent, ammonium acetate as a porogen, and chitosan as a surface-modification agent. Subsequently, doxorubicin (DOX), acting as a model drug (guest), was loaded onto the mesostructured Fe3O4/chitosan nanoparticles, with chitosan acting as a host molecule to form the NH2-Zn(II)-DOX coordination architecture. The release of DOX can be achieved through the cleavage of coordination bonds that are sensitive to variations in external pH under weakly acidic conditions. The pH-responsive nature of the nanoparticles was confirmed by in vitro releases and cell assay tests. Furthermore, the relaxation efficiency of the nanoparticles as high-performance magnetic resonance imaging contrast agents was also investigated. Experimental results confirm that the synthesized mesostructured Fe3O4/chitosan is a smart nanovehicle for drug delivery owing to both its pH-responsive nature and relaxation efficiency. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The SHiP experiment at CERN

NASA Astrophysics Data System (ADS)

Bonivento, Walter M.

2017-07-01

The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry of the Universe, deserving an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experiment at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using high intensity 400 GeV protons is a copious source of such unknown particles in the GeV mass range. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. The neutrino detector can also search for dark matter through its scattering off the electrons. We report the physics potential of the SHiP experiment.

76 FR 40945 - Rensselaer Polytechnic Institute Critical Experiments Facility; Notice of Issuance of Renewed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-225; NRC-2008-0277] Rensselaer Polytechnic Institute Critical Experiments Facility; Notice of Issuance of Renewed Facility Operating License No. CX-22 The U.S... of the Rensselaer Polytechnic Institute Critical Experiments Facility (RCF), located in Schenectady...

One-Pot Synthesis of Fe3O4@PS@P(AEMH-FITC) Magnetic Fluorescent Nanocomposites for Bimodal Imaging.

PubMed

Wang, Xuandong; Liu, Huiyu; Jun, Ren; Fu, Changhui; Li, Linlin; Li, Tianlong; Tang, Fangqiong; Meng, Xianwei

2016-03-01

Magnetic fluorescent nanocomposites have attracted much attention because of their merging magnetic and fluorescent properties for biomedical application. However, the procedure of synthesis of magnetic fluorescent nanocomposites is always complicated. In addition, the properties of fluorescent component could be easily influenced by magnetic component, retaining both of the magnetic and fluorescent properties into one single nanoparticle considered to be a significant challenge. Herein, we report one-pot method to synthesize multifunctional magnetic fluorescent Fe3O4@PS@P(AEMH-FITC) nanocomposites for bimodal imaging. The asprepared Fe3O4@PS@P(AEMH-FITC) nanocomposites with well-define spherical core/shell structure were stable properties. Moreover, the Fe3O4@PS@P(AEMH-FITC) nanocomposites displayed efficient fluorescent and magnetic properties, respectively. Meanwhile, the magnetic resonance imaging (MRI) and HePG2 cancer cell fluorescent images experiment results suggested that Fe3O4@PS@P(AEMH-FITC) nanocomposites could be used as MRI contrast agents and Fluorescence Imaging (FLI) agents for bioimaging application. Our investigation paves a facile avenue for synthesized magnetic fluorescent nanostructures with well biocompatibility for potential bioimaging application in MRI and FLI.

Integration and use of Microgravity Research Facility: Lessons learned by the crystals by vapor transport experiment and Space Experiments Facility programs

NASA Technical Reports Server (NTRS)

Heizer, Barbara L.

1992-01-01

The Crystals by Vapor Transport Experiment (CVTE) and Space Experiments Facility (SEF) are materials processing facilities designed and built for use on the Space Shuttle mid deck. The CVTE was built as a commercial facility owned by the Boeing Company. The SEF was built under contract to the UAH Center for Commercial Development of Space (CCDS). Both facilities include up to three furnaces capable of reaching 850 C minimum, stand-alone electronics and software, and independent cooling control. In addition, the CVTE includes a dedicated stowage locker for cameras, a laptop computer, and other ancillary equipment. Both systems are designed to fly in a Middeck Accommodations Rack (MAR), though the SEF is currently being integrated into a Spacehab rack. The CVTE hardware includes two transparent furnaces capable of achieving temperatures in the 850 to 870 C range. The transparent feature allows scientists/astronauts to directly observe and affect crystal growth both on the ground and in space. Cameras mounted to the rack provide photodocumentation of the crystal growth. The basic design of the furnace allows for modification to accommodate techniques other than vapor crystal growth. Early in the CVTE program, the decision was made to assign a principal scientist to develop the experiment plan, affect the hardware/software design, run the ground and flight research effort, and interface with the scientific community. The principal scientist is responsible to the program manager and is a critical member of the engineering development team. As a result of this decision, the hardware/experiment requirements were established in such a way as to balance the engineering and science demands on the equipment. Program schedules for hardware development, experiment definition and material selection, flight operations development and crew training, both ground support and astronauts, were all planned and carried out with the understanding that the success of the program science

Human insulin polymorphism upon ligand binding and pH variation: the case of 4-ethylresorcinol.

PubMed

Fili, S; Valmas, A; Norrman, M; Schluckebier, G; Beckers, D; Degen, T; Wright, J; Fitch, A; Gozzo, F; Giannopoulou, A E; Karavassili, F; Margiolaki, I

2015-09-01

This study focuses on the effects of the organic ligand 4-ethylresorcinol on the crystal structure of human insulin using powder X-ray crystallography. For this purpose, systematic crystallization experiments have been conducted in the presence of the organic ligand and zinc ions within the pH range 4.50-8.20, while observing crystallization behaviour around the isoelectric point of insulin. High-throughput crystal screening was performed using a laboratory X-ray diffraction system. The most representative samples were selected for synchrotron X-ray diffraction measurements, which took place at the European Synchrotron Radiation Facility (ESRF) and the Swiss Light Source (SLS). Four different crystalline polymorphs have been identified. Among these, two new phases with monoclinic symmetry have been found, which are targets for the future development of microcrystalline insulin drugs.

Human insulin polymorphism upon ligand binding and pH variation: the case of 4-ethylresorcinol

PubMed Central

Fili, S.; Valmas, A.; Norrman, M.; Schluckebier, G.; Beckers, D.; Degen, T.; Wright, J.; Fitch, A.; Gozzo, F.; Giannopoulou, A. E.; Karavassili, F.; Margiolaki, I.

2015-01-01

This study focuses on the effects of the organic ligand 4-ethylresorcinol on the crystal structure of human insulin using powder X-ray crystallography. For this purpose, systematic crystallization experiments have been conducted in the presence of the organic ligand and zinc ions within the pH range 4.50–8.20, while observing crystallization behaviour around the isoelectric point of insulin. High-throughput crystal screening was performed using a laboratory X-ray diffraction system. The most representative samples were selected for synchrotron X-ray diffraction measurements, which took place at the European Synchrotron Radiation Facility (ESRF) and the Swiss Light Source (SLS). Four different crystalline polymorphs have been identified. Among these, two new phases with monoclinic symmetry have been found, which are targets for the future development of microcrystalline insulin drugs. PMID:26306195

SHiP: a new facility to search for heavy neutrinos and study ντ properties

NASA Astrophysics Data System (ADS)

De Serio, M.; SHiP Collaboration

2016-05-01

SHiP (Search for Hidden Particles) is a newly designed fixed target facility, proposed at the CERN SPS accelerator, with the aim of complementing searches for New Physics at LHC by searching for light long-lived exotic particles with masses below a few GeV/c2. The sensitivity to Heavy Neutrinos will allow for the first time probing a region of the parameter space where Baryogenesis and active neutrino masses and oscillation could also be explained. A dedicated detector, based on OPERA-like bricks, will provide the first observation of the tau anti-neutrino. Moreover, ντ and ν¯τ cross-sections will be measured with a statistics 1000 times larger than currently available data and will allow extracting the F4 and F5 structure functions, never measured so far. Charm physics studies will be performed with significantly improved accuracy with respect to past experiments.

41 CFR 101-4.410 - Comparable facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Comparable facilities. 101-4.410 Section 101-4.410 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 4-NONDISCRIMINATION ON THE BASIS OF SEX IN...

Boiling Experiment Facility for Heat Transfer Studies in Microgravity

NASA Technical Reports Server (NTRS)

Delombard, Richard; McQuillen, John; Chao, David

2008-01-01

Pool boiling in microgravity is an area of both scientific and practical interest. By conducting tests in microgravity, it is possible to assess the effect of buoyancy on the overall boiling process and assess the relative magnitude of effects with regards to other "forces" and phenomena such as Marangoni forces, liquid momentum forces, and microlayer evaporation. The Boiling eXperiment Facility is now being built for the Microgravity Science Glovebox that will use normal perfluorohexane as a test fluid to extend the range of test conditions to include longer test durations and less liquid subcooling. Two experiments, the Microheater Array Boiling Experiment and the Nucleate Pool Boiling eXperiment will use the Boiling eXperiment Facility. The objectives of these studies are to determine the differences in local boiling heat transfer mechanisms in microgravity and normal gravity from nucleate boiling, through critical heat flux and into the transition boiling regime and to examine the bubble nucleation, growth, departure and coalescence processes. Custom-designed heaters will be utilized to achieve these objectives.

Low Gravity Freefall Facilities

NASA Technical Reports Server (NTRS)

1981-01-01

Composite of Marshall Space Flight Center's Low-Gravity Free Fall Facilities.These facilities include a 100-meter drop tower and a 100-meter drop tube. The drop tower simulates in-flight microgravity conditions for up to 4.2 seconds for containerless processing experiments, immiscible fluids and materials research, pre-flight hardware design test and flight experiment simulation. The drop tube simulates in-flight microgravity conditions for up to 4.6 seconds and is used extensively for ground-based microgravity convection research in which extremely small samples are studied. The facility can provide deep undercooling for containerless processing experiments that require materials to remain in a liquid phase when cooled below the normal solidification temperature.

A ``Cyber Wind Facility'' for HPC Wind Turbine Field Experiments

NASA Astrophysics Data System (ADS)

Brasseur, James; Paterson, Eric; Schmitz, Sven; Campbell, Robert; Vijayakumar, Ganesh; Lavely, Adam; Jayaraman, Balaji; Nandi, Tarak; Jha, Pankaj; Dunbar, Alex; Motta-Mena, Javier; Craven, Brent; Haupt, Sue

2013-03-01

The Penn State ``Cyber Wind Facility'' (CWF) is a high-fidelity multi-scale high performance computing (HPC) environment in which ``cyber field experiments'' are designed and ``cyber data'' collected from wind turbines operating within the atmospheric boundary layer (ABL) environment. Conceptually the ``facility'' is akin to a high-tech wind tunnel with controlled physical environment, but unlike a wind tunnel it replicates commercial-scale wind turbines operating in the field and forced by true atmospheric turbulence with controlled stability state. The CWF is created from state-of-the-art high-accuracy technology geometry and grid design and numerical methods, and with high-resolution simulation strategies that blend unsteady RANS near the surface with high fidelity large-eddy simulation (LES) in separated boundary layer, blade and rotor wake regions, embedded within high-resolution LES of the ABL. CWF experiments complement physical field facility experiments that can capture wider ranges of meteorological events, but with minimal control over the environment and with very small numbers of sensors at low spatial resolution. I shall report on the first CWF experiments aimed at dynamical interactions between ABL turbulence and space-time wind turbine loadings. Supported by DOE and NSF.

A facility to search for hidden particles at the CERN SPS: the SHiP physics case.

PubMed

Alekhin, Sergey; Altmannshofer, Wolfgang; Asaka, Takehiko; Batell, Brian; Bezrukov, Fedor; Bondarenko, Kyrylo; Boyarsky, Alexey; Choi, Ki-Young; Corral, Cristóbal; Craig, Nathaniel; Curtin, David; Davidson, Sacha; de Gouvêa, André; Dell'Oro, Stefano; deNiverville, Patrick; Bhupal Dev, P S; Dreiner, Herbi; Drewes, Marco; Eijima, Shintaro; Essig, Rouven; Fradette, Anthony; Garbrecht, Björn; Gavela, Belen; Giudice, Gian F; Goodsell, Mark D; Gorbunov, Dmitry; Gori, Stefania; Grojean, Christophe; Guffanti, Alberto; Hambye, Thomas; Hansen, Steen H; Helo, Juan Carlos; Hernandez, Pilar; Ibarra, Alejandro; Ivashko, Artem; Izaguirre, Eder; Jaeckel, Joerg; Jeong, Yu Seon; Kahlhoefer, Felix; Kahn, Yonatan; Katz, Andrey; Kim, Choong Sun; Kovalenko, Sergey; Krnjaic, Gordan; Lyubovitskij, Valery E; Marcocci, Simone; Mccullough, Matthew; McKeen, David; Mitselmakher, Guenakh; Moch, Sven-Olaf; Mohapatra, Rabindra N; Morrissey, David E; Ovchynnikov, Maksym; Paschos, Emmanuel; Pilaftsis, Apostolos; Pospelov, Maxim; Reno, Mary Hall; Ringwald, Andreas; Ritz, Adam; Roszkowski, Leszek; Rubakov, Valery; Ruchayskiy, Oleg; Schienbein, Ingo; Schmeier, Daniel; Schmidt-Hoberg, Kai; Schwaller, Pedro; Senjanovic, Goran; Seto, Osamu; Shaposhnikov, Mikhail; Shchutska, Lesya; Shelton, Jessie; Shrock, Robert; Shuve, Brian; Spannowsky, Michael; Spray, Andy; Staub, Florian; Stolarski, Daniel; Strassler, Matt; Tello, Vladimir; Tramontano, Francesco; Tripathi, Anurag; Tulin, Sean; Vissani, Francesco; Winkler, Martin W; Zurek, Kathryn M

2016-12-01

This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, [Formula: see text] and to search for weakly-interacting sub-GeV dark matter candidates. We discuss the evidence for physics beyond the standard model and describe interactions between new particles and four different portals-scalars, vectors, fermions or axion-like particles. We discuss motivations for different models, manifesting themselves via these interactions, and how they can be probed with the SHiP experiment and present several case studies. The prospects to search for relatively light SUSY and composite particles at SHiP are also discussed. We demonstrate that the SHiP experiment has a unique potential to discover new physics and can directly probe a number of solutions of beyond the standard model puzzles, such as neutrino masses, baryon asymmetry of the Universe, dark matter, and inflation.

Long Duration Exposure Facility (LDEF) attitude measurements of the Interplanetary Dust Experiment

NASA Technical Reports Server (NTRS)

Kassel, Philip C., Jr.; Motley, William R., III; Singer, S. Fred; Mulholland, J. Derral; Oliver, John P.; Weinberg, Jerry L.; Cooke, William J.; Wortman, Jim J.

1993-01-01

Analysis of the data from the Long Duration Exposure Facility (LDEF) Interplanetary Dust Experiment (IDE) sun sensors has allowed a confirmation of the attitude of LDEF during its first year in orbit. Eight observations of the yaw angle at specific times were made and are tabulated in this paper. These values range from 4.3 to 12.4 deg with maximum uncertainty of plus or minus 2.0 deg and an average of 7.9 deg. No specific measurements of pitch or roll were made but the data indicates that LDEF had an average pitch down attitude of less than 0.7 deg.

FEANICS: A Multi-User Facility For Conducting Solid Fuel Combustion Experiments On ISS

NASA Technical Reports Server (NTRS)

Frate, David T.; Tofil, Todd A.

2001-01-01

The Destiny Module on the International Space Station (ISS) will soon be home for the Fluids and Combustion Facility's (FCF) Combustion Integrated Rack (CIR), which is being developed at the NASA Glenn Research Center in Cleveland, Ohio. The CIR will be the platform for future microgravity combustion experiments. A multi-user mini-facility called FEANICS (Flow Enclosure Accommodating Novel Investigations in Combustion of Solids) will also be built at NASA Glenn. This mini-facility will be the primary means for conducting solid fuel combustion experiments in the CIR on ISS. The main focus of many of these solid combustion experiments will be to conduct basic and applied scientific investigations in fire-safety to support NASA's Bioastronautics Initiative. The FEANICS project team will work in conjunction with the CIR project team to develop upgradeable and reusable hardware to meet the science requirements of current and future investigators. Currently, there are six experiments that are candidates to use the FEANICS mini-facility. This paper will describe the capabilities of this mini-facility and the type of solid combustion testing and diagnostics that can be performed.

Evaluation of seasonal changes in methane flux in a wetland ecosystem using the Closed Geosphere Experiment Facility

NASA Astrophysics Data System (ADS)

Suzuki, S.; Inubushi, K.; Yokozawa, M.; Hara, T.; Nishidate, K.; Tsuga, S.; Tako, Y.; Nakamura, Y.

2009-04-01

To estimate CH4 emission from a wetland ecosystem to the atmosphere, seasonal change in CH4 flux was measured continuously in the Closed Geosphere Experiment Facility (CGEF). Plant-mediated transport is one of the important pathways for CH4 emission from Phragmites australis-dominated vegetation because most CH4 emission occurs through P. australis plant. The CGEF is equipped with a Geosphere Module (GM) and a Geosphere Material Circulation (GMC) system. The size of the GM is 5.8 m Ã- 8.7 m in ground area with an average height of 11.9 m, including the soil depth of 3.1 m. A wetland ecosystem dominated by P. australis was introduced into the GM. The CGEF can control air temperature and CO2 concentration in the GM automatically. Hourly CH4 flux from the wetland ecosystem can be calculated easily by measuring continuously the changes in CH4 concentration in air, air temperature and pressure in the GM. The method showed that monthly CH4 flux varied from 0.39 to 1.11 g C m-2 month-1 from April to November and the CH4 emission for the plant growing season (eight months) was 5.64 g C m-2. The CGEF has an advantage in studying total CH4 emission from soil to the atmosphere through plant-mediated transport, diffusion and ebullition because of the large size of the GM.

Gradient Heating Facility. Experiment cartridges. Description and general specifications

NASA Technical Reports Server (NTRS)

Breton, J.

1982-01-01

Specifications that define experiment cartridges that are compatible with the furnace of the gradient heating facility on board the Spacelab are presented. They establish a standard cartridge design independent of the type of experiment to be conducted. By using them, experimenters can design, construct, and test the hot section of the cartridge, known as the high temperature nacelle.

Microscope-Based Fluid Physics Experiments in the Fluids and Combustion Facility on ISS

NASA Technical Reports Server (NTRS)

Doherty, Michael P.; Motil, Susan M.; Snead, John H.; Malarik, Diane C.

2000-01-01

At the NASA Glenn Research Center, the Microgravity Science Program is planning to conduct a large number of experiments on the International Space Station in both the Fluid Physics and Combustion Science disciplines, and is developing flight experiment hardware for use within the International Space Station's Fluids and Combustion Facility. Four fluids physics experiments that require an optical microscope will be sequentially conducted within a subrack payload to the Fluids Integrated Rack of the Fluids and Combustion Facility called the Light Microscopy Module, which will provide the containment, changeout, and diagnostic capabilities to perform the experiments. The Light Microscopy Module is planned as a fully remotely controllable on-orbit microscope facility, allowing flexible scheduling and control of experiments within International Space Station resources. This paper will focus on the four microscope-based experiments, specifically, their objectives and the sample cell and instrument hardware to accommodate their requirements.

The Microgravity Research Experiments (MICREX) Data Base, Volume 4

NASA Technical Reports Server (NTRS)

Winter, C. A.; Jones, J. C.

1996-01-01

An electronic data base identifying over 800 fluids and materials processing experiments performed in a low-gravity environment has been created at NASA Marshall Space Flight Center. The compilation, called MICREX (MICrogravity Research Experiments), was designed to document all such experimental efforts performed (1) on U.S. manned space vehicles, (2) on payloads deployed from U.S. manned space vehicles, and (3) on all domestic and international sounding rockets (excluding those of China and the former U.S.S.R.). Data available on most experiments include (1) principal and co-investigators (2) low-gravity mission, (3) processing facility, (4) experimental objectives and results, (5) identifying key words, (6) sample materials, (7) applications of the processed materials/research area, (8) experiment descriptive publications, and (9) contacts for more information concerning the experiment. This technical Memorandum (1) summarizes the historical interest in reduced-gravity fluid dynamics, (2) describes the importance of a low-gravity fluids and materials processing data base, (4) describes the MICREX data base format and computational World Wide Web access procedures, and (5) documents (in hard-copy form) the descriptions of the first 600 fluids and materials processing experiments entered into MICREX.

Polar-Drive Experiments at the National Ignition Facility

NASA Astrophysics Data System (ADS)

Hohenberger, M.

2014-10-01

To support direct-drive inertial confinement fusion (ICF) experiments at the National Ignition Facility (NIF) in its indirect-drive beam configuration, the polar-drive (PD) concept has been proposed. It requires direct-drive-specific beam smoothing, phase plates, and repointing the NIF beams toward the equator to ensure symmetric target irradiation. First experiments testing the performance of ignition-relevant PD implosions at the NIF have been performed. The goal of these early experiments was to develop a stable, warm implosion platform to investigate laser deposition and laser-plasma instabilities at ignition-relevant plasma conditions, and to develop and validate ignition-relevant models of laser deposition and heat conduction. These experiments utilize the NIF in its current configuration, including beam geometry, phase plates, and beam smoothing. Warm, 2.2-mm-diam plastic shells were imploded with total drive energies ranging from ~ 350 to 750 kJ with peak powers of 60 to 180 TW and peak on-target intensities from 4 ×1014 to 1 . 2 ×1015 W/cm2. Results from these initial experiments are presented, including the level of hot-electron preheat, and implosion symmetry and shell trajectory inferred via self-emission imaging and backlighting. Experiments are simulated with the 2-D hydrodynamics code DRACO including a full 3-D ray trace to model oblique beams, and a model for cross-beam energy transfer (CBET). These simulations indicate that CBET affects the shell symmetry and leads to a loss of energy imparted onto the shell, consistent with the experimental data. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

A survey of experiments and experimental facilities for control of flexible structures

NASA Technical Reports Server (NTRS)

Sparks, Dean W., Jr.; Juang, Jer-Nan; Klose, Gerhard J.

1989-01-01

This paper presents a survey of U.S. ground experiments and facilities dedicated to the study of active control of flexible structures. The facilities will be briefly described in terms of capability, configuration, size and instrumentation. Topics on the experiments include vibration suppression, slewing and system identification. Future research directions, particularly of the NASA Langley Research Center's Controls/Structures Interaction (CSI) ground test program, will be discussed.

What makes or mars the facility-based childbirth experience: thematic analysis of women's childbirth experiences in western Kenya.

PubMed

Afulani, Patience A; Kirumbi, Leah; Lyndon, Audrey

2017-12-29

Sub-Saharan Africa accounts for approximately 66% of global maternal deaths. Poor person-centered maternity care, which emphasizes the quality of patient experience, contributes both directly and indirectly to these poor outcomes. Yet, few studies in low resource settings have examined what is important to women during childbirth from their perspective. The aim of this study is to examine women's facility-based childbirth experiences in a rural county in Kenya, to identify aspects of care that contribute to a positive or negative birth experience. Data are from eight focus group discussions conducted in a rural county in western Kenya in October and November 2016, with 58 mothers aged 15 to 49 years who gave birth in the preceding nine weeks. We recorded and transcribed the discussions and used a thematic approach for data analysis. The findings suggest four factors influence women's perceptions of quality of care: responsiveness, supportive care, dignified care, and effective communication. Women had a positive experience when they were received well at the health facility, treated with kindness and respect, and given sufficient information about their care. The reverse led to a negative experience. These experiences were influenced by the behavior of both clinical and support staff and the facility environment. This study extends the literature on person-centered maternity care in low resource settings. To improve person-centered maternity care, interventions need to address the responsiveness of health facilities, ensure women receive supportive and dignified care, and promote effective patient-provider communication.

UTEX: integrated ultraviolet and x-ray astronomy facility on spacelab, phase a study. Volume 4: development. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1976-07-01

A development and cost plan is proposed for the UTEX (Ultraviolet Telescope Experiment X-ray) telescope. Under certain assumptions, the UTEX facility can be developed in about 4 years. An overall development cost is given.

The Wake Shield Facility: A space experiment platform

NASA Technical Reports Server (NTRS)

Allen, Joseph P.

1991-01-01

Information is given in viewgraph form on Wakeshield, a space experiment platform. The Wake Shield Facility (WSF) flight program objectives, product applications, commercial development approach, and cooperative experiments are listed. The program objectives are to produce new industry-driven electronic, magnetic, and superconducting thin-film materials and devices both in terrestrial laboratories and in space; utilize the ultra-vacuum of space for thin film epitaxial growth and materials processing; and develop commercial space hardware for research and development and enhanced access to space.

Medical Care in a Free Clinic: A Comprehensive Evaluation of Patient Experience, Incentives, and Barriers to Optimal Medical Care with Consideration of a Facility Fee.

PubMed

Birs, Antoinette; Liu, Xinwei; Nash, Bee; Sullivan, Sara; Garris, Stephanie; Hardy, Marvin; Lee, Michael; Simms-Cendan, Judith; Pasarica, Magdalena

2016-02-19

Free and charitable clinics are important contributors to the health of the United States population. Recently, funding for these clinics has been declining, and it is, therefore, useful to identify what qualities patients value the most in clinics in an effort to allocate funding wisely. In order to identify targets and incentives for improvement of patients' health, we performed a comprehensive analysis of patients' experience at a free clinic by analyzing a patient survey (N=94). The survey also assessed patient opinions of a small facility fee, which could be used to offset the decrease in funds. Interestingly, our patients believed it is appropriate to be charged a facility fee (78%) because it increases involvement in their care (r = 0.69, p < 0.001) and self-respect (r = 0.66, p < 0.001). Incentives to medical care include continuity of care, faith-based care, having a patient medical provider partnership, and charging a facility fee. Barriers include affordable housing, transportation, medication, and accessible information. In order to improve medical care in the uninsured population, our study suggested that we need to: 1) offer continuity of medical care; 2) offer affordable preventive health screenings; 3) support affordable transportation, housing, and medications; and 4) consider including a facility fee.

The 4MOST facility control software

NASA Astrophysics Data System (ADS)

Pramskiy, Alexander; Mandel, Holger; Rothmaier, Florian; Stilz, Ingo; Winkler, Roland; Hahn, Thomas

2016-07-01

The 4-m Multi-Object Spectrographic Telescope (4MOST) is one high-resolution (R 18000) and two lowresolution (R fi 5000) spectrographs covering the wavelength range between 390 and 950 nm. The spectrographs will be installed on ESO VISTA telescope and will be fed by approximately 2400 fibres. The instrument is capable to simultaneously obtain spectra of about 2400 objects distributed over an hexagonal field-of-view of four square degrees. This paper aims at giving an overview of the control software design, which is based on the standard ESO VLT software architecture and customised to fit the needs of the 4MOST instrument. In particular, the facility control software is intended to arrange the precise positioning of the fibres, to schedule and observe many surveys in parallel, and to combine the output from the three spectrographs. Moreover, 4MOST's software will include user-friendly graphical user interfaces that enable users to interact with the facility control system and to monitor all data-taking and calibration tasks of the instrument. A secondary guiding system will be implemented to correct for any fibre exure and thus to improve 4MOST's guiding performance. The large amount of fibres requires the custom design of data exchange to avoid performance issues. The observation sequences are designed to use spectrographs in parallel with synchronous points for data exchange between subsystems. In order to control hardware devices, Programmable Logic Controller (PLC) components will be used, the new standard for future instruments at ESO.

10 CFR 451.4 - What is a qualified renewable energy facility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false What is a qualified renewable energy facility. 451.4 Section 451.4 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES § 451.4 What is a qualified renewable energy facility. In order to qualify for an incentive payment under...

10 CFR 451.4 - What is a qualified renewable energy facility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false What is a qualified renewable energy facility. 451.4 Section 451.4 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES § 451.4 What is a qualified renewable energy facility. In order to qualify for an incentive payment under...

10 CFR 451.4 - What is a qualified renewable energy facility.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false What is a qualified renewable energy facility. 451.4 Section 451.4 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES § 451.4 What is a qualified renewable energy facility. In order to qualify for an incentive payment under...

10 CFR 451.4 - What is a qualified renewable energy facility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false What is a qualified renewable energy facility. 451.4 Section 451.4 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES § 451.4 What is a qualified renewable energy facility. In order to qualify for an incentive payment under...

10 CFR 451.4 - What is a qualified renewable energy facility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false What is a qualified renewable energy facility. 451.4 Section 451.4 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES § 451.4 What is a qualified renewable energy facility. In order to qualify for an incentive payment under...

Rugby and elliptical-shaped hohlraums experiments on the OMEGA laser facility

NASA Astrophysics Data System (ADS)

Tassin, Veronique; Monteil, Marie-Christine; Depierreux, Sylvie; Masson-Laborde, Paul-Edouard; Philippe, Franck; Seytor, Patricia; Fremerye, Pascale; Villette, Bruno

2017-10-01

We are pursuing on the OMEGA laser facility indirect drive implosions experiments in gas-filled rugby-shaped hohlraums in preparation for implosion plateforms on LMJ. The question of the precise wall shape of rugby hohlraum has been addressed as part of future megajoule-scale ignition designs. Calculations show that elliptical-shaped holhraum is more efficient than spherical-shaped hohlraum. There is less wall hydrodynamics and less absorption for the inner cone, provided a better control of time-dependent symmetry swings. In this context, we have conducted a series of experiments on the OMEGA laser facility. The goal of these experiments was therefore to characterize energetics with a complete set of laser-plasma interaction measurements and capsule implosion in gas-filled elliptical-shaped hohlraum with comparison with spherical-shaped hohlraum. Experiments results are discussed and compared to FCI2 radiation hydrodynamics simulations.

15 CFR 712.4 - New Schedule 1 production facility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility in...

15 CFR 712.4 - New Schedule 1 production facility.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 1 CHEMICALS § 712.4 New Schedule 1 production facility. (a) Establishment of a...) of the CWCR, and you intend to begin production of Schedule 1 chemicals at your facility in...

Simulation of German PKL refill/reflood experiment K9A using RELAP4/MOD7. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, M.T.; Davis, C.B.; Behling, S.R.

This paper describes a RELAP4/MOD7 simulation of West Germany's Kraftwerk Union (KWU) Primary Coolant Loop (PKL) refill/reflood experiment K9A. RELAP4/MOD7, a best-estimate computer program for the calculation of thermal and hydraulic phenomena in a nuclear reactor or related system, is the latest version in the RELAP4 code development series. This study was the first major simulation using RELAP4/MOD7 since its release by the Idaho National Engineering Laboratory (INEL). The PKL facility is a reduced scale (1:134) representation of a typical West German four-loop 1300 MW pressurized water reactor (PWR). A prototypical scale of the total volume to power ratio wasmore » maintained. The test facility was designed specifically for an experiment simulating the refill/reflood phase of a Loss-of-Coolant Accident (LOCA).« less

Using a qualitative approach for understanding hospital-affiliated integrated clinical and fitness facilities: characteristics and members' experiences.

PubMed

Yang, Jingzhen; Kingsbury, Diana; Nichols, Matthew; Grimm, Kristin; Ding, Kele; Hallam, Jeffrey

2015-06-19

With health care shifting away from the traditional sick care model, many hospitals are integrating fitness facilities and programs into their clinical services in order to support health promotion and disease prevention at the community level. Through a series of focus groups, the present study assessed characteristics of hospital-affiliated integrated facilities located in Northeast Ohio, United States and members' experiences with respect to these facilities. Adult members were invited to participate in a focus group using a recruitment flyer. A total of 6 focus groups were conducted in 2013, each lasting one hour, ranging from 5 to 12 participants per group. The responses and discussions were recorded and transcribed verbatim, then analyzed independently by research team members. Major themes were identified after consensus was reached. The participants' average age was 57, with 56.8% currently under a doctor's care. Four major themes associated with integrated facilities and members' experiences emerged across the six focus groups: 1) facility/program, 2) social atmosphere, 3) provider, and 4) member. Within each theme, several sub-themes were also identified. A key feature of integrated facilities is the availability of clinical and fitness services "under one roof". Many participants remarked that they initially attended physical therapy, becoming members of the fitness facility afterwards, or vice versa. The participants had favorable views of and experiences with the superior physical environment and atmosphere, personal attention, tailored programs, and knowledgeable, friendly, and attentive staff. In particular, participants favored the emphasis on preventive care and the promotion of holistic health and wellness. These results support the integration of wellness promotion and programming with traditional medical care and call for the further evaluation of such a model with regard to participants' health outcomes.

FPIN2 posttest analysis of cylindrical canisters in SLSF Experiment P4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, T H; Kramer, J M

Results demonstrate that the clad deformation is dominated by the expansion of the fuel when it melts. In our analysis we moved the end space volume and some of the fuel-clad radial gap volume to an artificial central hole. This approximation may affect the details in the early parts of the transient, but clearly did not affect the major cladding deformation. It is also clear that the accuracy of the value of the fuel expansion upon melting is significant as is the dimensional accuracy of the fuel and canisters. The major conclusions from the FPIN2 posttest analysis of the cylindricalmore » canisters in SLSF Experiment P4 are: The maximum melt fractions in the two canisters were about 75%. Both canisters experienced about the same diametral strains of 12% prior to failure. These strains were almost entirely due to the additional volume that must be created inside the canisters to accommodate the expansion of fuel on melting. The mode of cladding failure was plastic instability by necking of the canister walls. The failure time of the 20% CW canister and the nonmechanical failure of the 10% CW canister are consistent with the FPIN2 calculations using the plastic instability failure criteria.« less

Removal of Covalent Heterogeneity Reveals Simple Folding Behavior for P4-P6 RNA*

PubMed Central

Greenfeld, Max; Solomatin, Sergey V.; Herschlag, Daniel

2011-01-01

RNA folding landscapes have been described alternately as simple and as complex. The limited diversity of RNA residues and the ability of RNA to form stable secondary structures prior to adoption of a tertiary structure would appear to simplify folding relative to proteins. Nevertheless, there is considerable evidence for long-lived misfolded RNA states, and these observations have suggested rugged energy landscapes. Recently, single molecule fluorescence resonance energy transfer (smFRET) studies have exposed heterogeneity in many RNAs, consistent with deeply furrowed rugged landscapes. We turned to an RNA of intermediate complexity, the P4-P6 domain from the Tetrahymena group I intron, to address basic questions in RNA folding. P4-P6 exhibited long-lived heterogeneity in smFRET experiments, but the inability to observe exchange in the behavior of individual molecules led us to probe whether there was a non-conformational origin to this heterogeneity. We determined that routine protocols in RNA preparation and purification, including UV shadowing and heat annealing, cause covalent modifications that alter folding behavior. By taking measures to avoid these treatments and by purifying away damaged P4-P6 molecules, we obtained a population of P4-P6 that gave near-uniform behavior in single molecule studies. Thus, the folding landscape of P4-P6 lacks multiple deep furrows that would trap different P4-P6 molecules in different conformations and contrasts with the molecular heterogeneity that has been seen in many smFRET studies of structured RNAs. The simplicity of P4-P6 allowed us to reliably determine the thermodynamic and kinetic effects of metal ions on folding and to now begin to build more detailed models for RNA folding behavior. PMID:21478155

S100A4 interacts with p53 in the nucleus and promotes p53 degradation.

PubMed

Orre, L M; Panizza, E; Kaminskyy, V O; Vernet, E; Gräslund, T; Zhivotovsky, B; Lehtiö, J

2013-12-05

S100A4 is a small calcium-binding protein that is commonly overexpressed in a range of different tumor types, and it is widely accepted that S100A4 has an important role in the process of cancer metastasis. In vitro binding assays has shown that S100A4 interacts with the tumor suppressor protein p53, indicating that S100A4 may have additional roles in tumor development. In the present study, we show that endogenous S100A4 and p53 interact in complex samples, and that the interaction increases after inhibition of MDM2-dependent p53 degradation using Nutlin-3A. Further, using proximity ligation assay, we show that the interaction takes place in the cell nucleus. S100A4 knockdown experiments in two p53 wild-type cell lines, A549 and HeLa, resulted in stabilization of p53 protein, indicating that S100A4 is promoting p53 degradation. Finally, we demonstrate that S100A4 knockdown leads to p53-dependent cell cycle arrest and increased cisplatin-induced apoptosis. Thus, our data add a new layer to the oncogenic properties of S100A4 through its inhibition of p53-dependent processes.

Biasing experiments on the Advanced Toroidal Facility

NASA Astrophysics Data System (ADS)

Uckan, T.; Isler, R. C.; Jernigan, T. C.; Lyon, J. F.; Mioduszewski, P. K.; Murakami, M.; Rasmussen, D. A.; Wilgen, J. B.; Aceto, S. C.; Zielinski, J. J.

1992-09-01

Biasing experiments have been carried out in 1 T plasmas with approximately 200 kW of electron cyclotron heating (ECH) in the current-fire Advanced Toroidal Facility (ATF) torsatron. Two rail limiters, one at the top and one at the bottom of the device, located at the last closed flux surface (LCFS), are, biased at positive and negative potentials with respect to the vacuum vessel. When the limiters are positively biased at up to 300 V and the plasma density is controlled with a significantly reduced gas feed, the H(sub alpha) radiation from both the limiter and the wall drops, indicating reduced particle recycling as a result of improved particle confinement. For bias voltages around +100 V, there is almost no change of plasma stored energy W(sub p), but W(sub p) then drops with the higher biasing voltages. Positive biasing has caused the core plasma density profile to become peaked and the electric field to become more negative inside the LCFS. At the same time, edge plasma fluctuations are reduced significantly and their power spectrum becomes less broad. The propagation direction of these electrostatic fluctuations reverses to the ion diamagnetic direction, and their wavelengths become longer. The resulting fluctuation-induced particle flux is also reduced. Power deposition on the limiters is lower as a result of reduced edge plasma density and temperature. Negative biasing yields somewhat less improvement in the particle confinement while having almost no apparent effect on W(sub p) or on the core and the edge plasma density and temperature profiles. Simultaneous measurements of the plasma potential profile indicate almost no significant change. Biasing has almost no effect on the intrinsic impurity levels in the plasma.

Status and Plans for the FLARE (Facility for Laboratory Reconnection Experiments) Project

NASA Astrophysics Data System (ADS)

Ji, H.; Bhattacharjee, A.; Prager, S.; Daughton, W.; Bale, S.; Carter, T.; Crocker, N.; Drake, J.; Egedal, J.; Sarff, J.; Wallace, J.; Chen, Y.; Cutler, R.; Fox, W.; Heitzenroeder, P.; Kalish, M.; Jara-Almonte, J.; Myers, C.; Ren, Y.; Yamada, M.; Yoo, J.

2015-11-01

The FLARE device (flare.pppl.gov) is a new intermediate-scale plasma experiment under construction at Princeton to study magnetic reconnection in regimes directly relevant to space, solar, astrophysical, and fusion plasmas. The existing small-scale experiments have been focusing on the single X-line reconnection process either with small effective sizes or at low Lundquist numbers, but both of which are typically very large in natural and fusion plasmas. The design of the FLARE device is motivated to provide experimental access to the new regimes involving multiple X-lines, as guided by a reconnection ``phase diagram'' [Ji & Daughton, PoP (2011)]. Most of major components of the FLARE device have been designed and are under construction. The device will be assembled and installed in 2016, followed by commissioning and operation in 2017. The planned research on FLARE as a user facility will be discussed. Supported by NSF.

H(C)P and H(P)C triple-resonance experiments at natural abundance employing long-range couplings.

PubMed

Malon, Michal; Koshino, Hiroyuki

2007-09-01

Modified two-dimensional (2D) triple-resonance H(C)P and H(P)C experiments based on INEPT/HMQC and double-INEPT schemes are applied to the study of organophosphorus compounds at natural abundances. The implementation of effective (1)H--(13)C gradient selection, additional purging pulsed field gradients, spinlock pulses, and improved phase cycling is demonstrated to allow weak correlation signals based on long-range couplings to be readily observed. Through the combination of two heteronuclear long-range coupling constants, (n)J(CH) and (n)J(PC) in H(C)P experiments or (n)J(PH) and (n)J(PC) in H(P)C experiments, protons can be correlated to a second heteronucleus through 4-7 chemical bonds. These experiments thus overcome the inherit limitations of classical (1)H-X HMBC experiments, which require a nonzero value of the heteronuclear coupling constant (n)J(XH). Ultra-broadband inversion composite pulses are successfully employed in the H(P)C INEPT/HMQC and H(P)C double-INEPT pulse sequences to increase the utility of the experiments and the quality of obtained spectra. This work extends and completes a set of 2D phase-sensitive triple-resonance experiments applicable at natural abundances, and also offers insight into the methodology of triple-resonance experiments and the application of pulsed field gradients. A one-dimensional triple-resonance experiment employing carbon detection is suggested for accurate determination of small (n)J(PC).

Meiotic and pedigree segregation analyses in carriers of t(4;8)(p16;p23.1) differing in localization of breakpoint positions at 4p subband 4p16.3 and 4p16.1.

PubMed

Midro, Alina T; Zollino, Marcella; Wiland, Ewa; Panasiuk, Barbara; Iwanowski, Piotr S; Murdolo, Marina; Śmigiel, Robert; Sąsiadek, Maria; Pilch, Jacek; Kurpisz, Maciej

2016-02-01

The purpose of this study was to compare meiotic segregation in sperm cells from two carriers with t(4;8)(p16;p23.1) reciprocal chromosome translocations (RCTs), differing in localization of the breakpoint positions at the 4p subband-namely, 4p16.3 (carrier 1) and 4p16.1 (carrier 2)-and to compare data of the pedigree analyses performed by direct method. Three-color fluorescent in situ hybridization (FISH) on sperm cells and FISH mapping for the evaluation of the breakpoint positions, data from pedigrees, and direct segregation analysis of the pedigrees were performed. Similar proportions of normal/balanced and unbalanced sperm cells were found in both carriers. The most common was an alternate type of segregation (about 52 % and about 48 %, respectively). Unbalanced adjacent I and adjacent II karyotypes were found in similar proportions about 15 %. The direct segregation analysis (following Stengel-Rutkowski) of the pedigree of carriers of t(4;8)(p16.1;p23.1) was performed and results were compared with the data of the pedigree segregation analysis obtained earlier through the indirect method. The probability of live-born progeny with unbalanced karyotype for carriers of t(4;8)(p16.1;p23.1) was moderately high at 18.8 %-comparable to the value obtained using the indirect method for the same carriership, which was 12 %. This was, however, markedly lower than the value of 41.2 % obtained through the pedigree segregation indirect analysis estimated for carriers of t(4;8)(p16.3;p23.1), perhaps due to the unique composition of genes present within the 4p16.1-4p 16.3 region. Revealed differences in pedigree segregation analysis did not correspond to the very similar profile of meiotic segregation patterns presented by carrier 1 and carrier 2. Most probably, such discordances may be due to differences in embryo survival rates arising from different genetic backgrounds.

Discriminative facility and its role in the perceived quality of interactional experiences.

PubMed

Cheng, C; Chiu, C Y; Hong, Y Y; Cheung, J S

2001-10-01

Discriminative facility refers to an individual's sensitivity to subtle cues about the psychological meaning of a situation. This research aimed at examining (a) the conceptual distinctiveness of discriminative facility, (b) the situation-appropriate aspect of this construct, and (c) the relationship between discriminative facility and interpersonal experiences. Discriminative facility was assessed by a new measure of situation-appropriate behaviors across a variety of novel stressful situations. Results from study 1 showed that discriminative facility had weak positive relationships with cognitive complexity and nonsignificant relationships with self-monitoring and social desirability, indicating that discriminative facility is a unique construct. Results from Study 2 revealed that higher levels of discriminative facility were associated with higher levels of perceived social support and a greater number of pleasant interpersonal events experienced, thus providing support for the theoretical proposition that discriminative facility is an aspect of social intelligence.

10 CFR 4.550 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Program accessibility: Existing facilities. 4.550 Section 4.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR... changes shall be made by August 22, 1989, but in any event as expeditiously as possible. (d) Transition...

10 CFR 4.550 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Program accessibility: Existing facilities. 4.550 Section 4.550 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR... changes shall be made by August 22, 1989, but in any event as expeditiously as possible. (d) Transition...

Low-gravity impact experiments: Progress toward a facility definition

NASA Technical Reports Server (NTRS)

Cintala, M. J.

1986-01-01

Innumerable efforts were made to understand the cratering process and its ramifications in terms of planetary observations, during which the role of gravity has often come into question. Well known facilities and experiments both were devoted in many cases to unraveling the contribution of gravitational acceleration to cratering mechanisms. Included among these are the explosion experiments in low gravity aircraft, the drop platform experiments, and the high gravity centrifuge experiments. Considerable insight into the effects of gravity was gained. Most investigations were confined to terrestrial laboratories. It is in this light that the Space Station is being examined as a vehicle with the potential to support otherwise impractical impact experiments. The results of studies performed by members of the planetary cratering community are summarized.

48 CFR 215.404-71-4 - Facilities capital employed.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the facilities capital cost of money and capital employed using— (1) An analysis of the appropriate Forms CASB-CMF and cost of money factors (48 CFR 9904.414 and FAR 31.205-10); and (2) DD Form 1861, Contract Facilities Capital Cost of Money. (c) Use of DD Form 1861. See PGI 215.404-71-4(c) for obtaining...

48 CFR 215.404-71-4 - Facilities capital employed.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the facilities capital cost of money and capital employed using— (1) An analysis of the appropriate Forms CASB-CMF and cost of money factors (48 CFR 9904.414 and FAR 31.205-10); and (2) DD Form 1861, Contract Facilities Capital Cost of Money. (c) Use of DD Form 1861. See PGI 215.404-71-4(c) for obtaining...

48 CFR 215.404-71-4 - Facilities capital employed.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the facilities capital cost of money and capital employed using— (1) An analysis of the appropriate Forms CASB-CMF and cost of money factors (48 CFR 9904.414 and FAR 31.205-10); and (2) DD Form 1861, Contract Facilities Capital Cost of Money. (c) Use of DD Form 1861. See PGI 215.404-71-4(c) for obtaining...

P dopants induced ferromagnetism in g-C3N4 nanosheets: Experiments and calculations

NASA Astrophysics Data System (ADS)

Liu, Yonggang; Liu, Peitao; Sun, Changqi; Wang, Tongtong; Tao, Kun; Gao, Daqiang

2017-05-01

Outstanding magnetic properties are highly desired for two-dimensional (2D) semiconductor nanosheets due to their potential applications in spintronics. Metal-free ferromagnetic 2D materials whose magnetism originated from the pure s/p electron configuration could give a long spin relaxation time, which plays the vital role in spin information transfer. Here, we synthesize 2D g-C3N4 nanosheets with room temperature ferromagnetism induced by P doping. In our case, the Curie temperature of P doped g-C3N4 nanosheets reaches as high as 911 K and the precise control of the P concentration can further adjust the saturation magnetization of the samples. First principles calculation results indicate that the magnetic moment is primarily due to strong hybridization between p bonds of P, N, and C atoms, giving the theoretical evidence of the ferromagnetism. This work opens another door to engineer a future generation of spintronic devices.

Assessing performance enhancing tools: experiences with the open performance review and appraisal system (OPRAS) and expectations towards payment for performance (P4P) in the public health sector in Tanzania.

PubMed

Songstad, Nils Gunnar; Lindkvist, Ida; Moland, Karen Marie; Chimhutu, Victor; Blystad, Astrid

2012-09-10

Health workers' motivation is a key determinant of the quality of health services, and poor motivation has been found to be an obstacle to service delivery in many low-income countries. In order to increase the quality of service delivery in the public sector in Tanzania, the Open Performance Review and Appraisal System (OPRAS) has been implemented, and a new results-based payment system, Payment for performance (P4P) is introduced in the health sector. This article addresses health workers' experiences with OPRAS, expectations towards P4P and how lessons learned from OPRAS can assist in the implementation of P4P. The broader aim is to generate knowledge on health workers' motivation in low-income contexts. A qualitative study design has been employed to elicit data on health worker motivation at a general level and in relation to OPRAS and P4P in particular. Focus group discussions (FGDs) and in-depth interviews (IDIs) have been conducted with nursing staff, clinicians and administrators in the public health sector in a rural district in Tanzania. The study has an ethnographic backdrop based on earlier long-term fieldwork in Tanzania. Health workers evaluated OPRAS and P4P in terms of the benefits experienced or expected from complying with the tools. The study found a general reluctance towards OPRAS as health workers did not see OPRAS as leading to financial gains nor did it provide feedback on performance. Great expectations were expressed towards P4P due to its prospects of topping up salaries, but the links between the two performance enhancing tools were unclear. Health workers respond to performance enhancing tools based on whether the tools are found appropriate or yield any tangible benefits. The importance placed on salary and allowances forms the setting in which OPRAS operates. The expected addition to the salary through P4P has created a vigorous discourse among health workers attesting to the importance of the salary for motivation. Lessons learned

Assessing performance enhancing tools: experiences with the open performance review and appraisal system (OPRAS) and expectations towards payment for performance (P4P) in the public health sector in Tanzania

PubMed Central

2012-01-01

Background Health workers’ motivation is a key determinant of the quality of health services, and poor motivation has been found to be an obstacle to service delivery in many low-income countries. In order to increase the quality of service delivery in the public sector in Tanzania, the Open Performance Review and Appraisal System (OPRAS) has been implemented, and a new results-based payment system, Payment for performance (P4P) is introduced in the health sector. This article addresses health workers’ experiences with OPRAS, expectations towards P4P and how lessons learned from OPRAS can assist in the implementation of P4P. The broader aim is to generate knowledge on health workers’ motivation in low-income contexts. Methods A qualitative study design has been employed to elicit data on health worker motivation at a general level and in relation to OPRAS and P4P in particular. Focus group discussions (FGDs) and in-depth interviews (IDIs) have been conducted with nursing staff, clinicians and administrators in the public health sector in a rural district in Tanzania. The study has an ethnographic backdrop based on earlier long-term fieldwork in Tanzania. Results Health workers evaluated OPRAS and P4P in terms of the benefits experienced or expected from complying with the tools. The study found a general reluctance towards OPRAS as health workers did not see OPRAS as leading to financial gains nor did it provide feedback on performance. Great expectations were expressed towards P4P due to its prospects of topping up salaries, but the links between the two performance enhancing tools were unclear. Conclusions Health workers respond to performance enhancing tools based on whether the tools are found appropriate or yield any tangible benefits. The importance placed on salary and allowances forms the setting in which OPRAS operates. The expected addition to the salary through P4P has created a vigorous discourse among health workers attesting to the importance of

Preservice Teachers' Experiences Facilitating Writing Instruction in a Juvenile Detention Facility

ERIC Educational Resources Information Center

Pytash, Kristine E.

2017-01-01

A myriad of personal and contextual factors are important in understanding how preservice teachers learn to teach and why they adopt or reject certain teaching practices. Activity theory was used a framework in understand preservice teachers' experiences teaching writing during a field experience at a juvenile detention facility. The purposes of…

Performance of the 2 × 4-cell superconducting linac module for the THz-FEL facility

NASA Astrophysics Data System (ADS)

Kui, Zhou; Chenglong, Lao; Dai, Wu; Xing, Luo; Jianxin, Wang; Dexin, Xiao; Lijun, Shan; Tianhui, He; Xuming, Shen; Sifen, Lin; Linde, Yang; Hanbin, Wang; Xingfan, Yang; Ming, Li; Xiangyang, Lu

2018-07-01

A high average power THz radiation facility has been developed by the China Academy of Engineering Physics. It is the first CW THz user facility based on superconducting accelerator technology in China. The superconducting linac module, which contains two 4-cell 1.3 GHz TESLA-like superconducting radio frequency cavities, is a major component of this facility. The expected electron energy gain is 6-8 MeV with a field gradient of 8-10 MV/m. The design and fabrication of the linac module is complete. This paper discusses its assembly and results from cyromodule tests and beam commissioning. At 2 K, the cryomodule works smoothly and stably. Both cavities have achieved effective field gradients of 10 MV/m. In beam loading experiments, 8 MeV, 5 mA electron beams with an energy spread less than 0.2% have been produced, which satisfies our requirements.

The Long Duration Exposure Facility (LDEF). Mission 1 Experiments.

ERIC Educational Resources Information Center

Clark, Lenwood G., Ed.; And Others

The Long Duration Exposure Facility (LDEF) has been designed to take advantage of the two-way transportation capability of the space shuttle by providing a large number of economical opportunities for science and technology experiments that require modest electrical power and data processing while in space and which benefit from postflight…

Magnetic Flyer Facility Correlation and UGT Simulation

DTIC Science & Technology

1978-05-01

AND UGT SIMULATION (U) Kaman Sciences Corporation L ~ P.O. Box 7463 I Colorado Springs, Colcerado 80933 ý4 May 1978DC Final Report CONTRACT No. DNA O01...selected underground test ( UGT ) environment on 3DQP; and, (2) To correlate the magnetically driven flyer plate facilities of VKSC with those of the...tailored to matcb the pressure vs. time anid total impulse measurements obtained on UGT events. This matching of experi- mental data required considerable

First experiment on LMJ facility: pointing and synchronisation qualification, sequences qualification

NASA Astrophysics Data System (ADS)

Henry, Olivier; Bretheau, Dominique; Luttmann, Michel; Graillot, Herve; Ferri, Michel; Seguineau, Frederic; Bar, Emmanuel; Patissou, Loic; Canal, Phillipe; Sautarel, Françoise; Tranquille Marques, Yves; Raffestin, Didier

2016-10-01

The LMJ (Laser mega Joule) facility at the CESTA site (Aquitaine, France) is a tool designed to deliver up to 1.2 MJ at 351 nm for plasma experiments. The experiment system will include 11 diagnostics: UV and X energy balances, imagers (Streak and stripe camera, CCD), spectrometers, and a Visar/pyrometer. The facility must be able to deliver, within the hour following the shot, all the results of the plasma diagnostics, alignment images and laser diagnostic measurements. These results have to be guaranteed in terms of conformity to the request and quality of measurement. The end of 2014 was devoted to the qualification of system pointing on target and synchronization within and between beams. The shots made with one chain (divided in 2 quads - 8 laser beams) have achieved 50 µm of misalignment accuracy (chain and quad channel) and a synchronization accuracy in the order of 50 ps. The performances achieved for plasma diagnostic (in the order of less 100 µm of alignment and timing accuracy less than 150 ps) comply with expectations. At the same time the first automatic sequences were tested. They allowed a shot on target every 6h:30 and in some case twice a day by reducing preparation actions, leading to a sequence of 4h:00. These shooting sequences are managed by an operating team of 7 people helped by 3 people for security aspects.

European Microgravity Facilities for ZEOLITE Experiments on the International Space Station

NASA Astrophysics Data System (ADS)

Pletser, V.; Minster, O.; Kremer, S.; Kirschhock, C.; Martens, J.; Jacobs, P.

2002-01-01

Synthetic zeolites are complex porous silicates. Zeolites are applied as catalysts, adsorbents and sensors. Whereas the traditional applications are situated in the petrochemical area, zeolite catalysis and related zeolite-based technologies have a growing impact on the economics and sustainability of products and processes in a growing number of industrial sectors, including environmental protection and nanotechnology. A Sounding Rocket microgravity experiment led to significant insight in the physical aggregation patterns of zeolitic nanoscopic particles and the occurrence of self-organisation phenomena when undisturbed by convection. The opportunity of performing longer microgravity duration experiments on zeolite structures was recently offered in the frame of a Taxi-Flight to the ISS in November 2002 organized by Belgium and ESA. Two facilities are currently under development for this flight. One of them will use the Microgravity Science Glovebox (MSG) in the US Lab. Destiny to achieve thermal induced self-organization of different types of Zeosil nanoslabs by heating and cooling. The other facility will be flown on the ISS Russian segment and will allow to form Zeogrids at ambient temperature. On the other hand, the European Space Agency (ESA) is studying the possibility of developing a dedicated insert for zeolite experiments to be used with the optical and diagnostic platform of the Protein Crystallisation Diagnostic Facility (PCDF), that will fly integrated in the European Drawer Rack on the Columbus Laboratory starting in 2004. This paper will present the approach followed by ESA to prepare and support zeolite investigations in microgravity and will present the design concept of these three facilities.

Extension of drop experiments with the MIKROBA balloon drop facility

NASA Astrophysics Data System (ADS)

Sommer, K.; Kretzschmar, K.; Dorn, C.

1992-12-01

The German balloon drop facility MIKROBA extends the worldwide available drop experiment opportunities to the presently highest usable experimentation time span of 55 s at microgravity conditions better than 0.001 g. The microgravity period is started with the typical quasi-deal step function from 1 to 0 g. MIKROBA allows flexible experiment design, short access time, and easy hands-on payload integration. The transport to the operational height is realized by soft energies and technologies compatible with the earth's environment. Balloon campaigns are not restricted to a certain test range, i.e., several suitable sites are available all over the world. MIKROBA combines negligible mechanical loads at the mission start, typical of all drop facilities, with extremely low drop deceleration loads (less than g), due to the implemented three-stage parachute and airbag recovery subsystem.

First Iron Opacity Experiments on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Perry, Theodore; Dodd, Evan; Cardenas, Tana; Devolder, Barbara; Flippo, Kirk; Johns, Heather; Kline, John; Sherrill, Manolo; Urbatsch, Todd; Heeter, Robert; Ahmed, Maryum; Emig, James; Iglesias, Carlos; Liedahl, Duane; London, Richard; Martin, Madison; Schneider, Marilyn; Thompson, Nathaniel; Wilson, Brian; Opachich, Yekaterina; King, James; Huffman, Eric; Knight, Russel; Bailey, James; Rochau, Gregory

2017-10-01

Iron opacity experiments on the Sandia National Laboratories Z machine have shown up to factors of two discrepancies between theory and experiment. To help resolve these discrepancies an experimental platform for doing comparable opacity experiments is being developed on the National Ignition Facility (NIF). Initial iron data has been taken at a temperature of 150 eV and an electron density of 6x1021/cm3, but higher temperatures and densities will be required to address the discrepancies that have been observed in the Z experiments. The plans to go to higher temperatures and densities and how to deal with current issues with instrumental backgrounds will be discussed. Performed under the auspices of USDOE LANL Contract DE-AC52-06NA25396.

Facile preparation of oxazole-4-carboxylates and 4-ketones from aldehydes using 3-oxazoline-4-carboxylates as intermediates.

PubMed

Murai, Kenichi; Takahara, Yusuke; Matsushita, Tomoyo; Komatsu, Hideyuki; Fujioka, Hiromichi

2010-08-06

A novel 2-step synthesis of oxazole-4-carboxylates from aldehydes was developed, which is characterized by the utilization of 3-oxazoline-4-carboxylates as synthetic intermediates. The facile preparation of 4-keto-oxazole derivatives from 3-oxazoline-4-carboxylates based on their interesting reactivity toward Grignard reagents is also described.

The SHiP experiment at CERN SPS

NASA Astrophysics Data System (ADS)

Di Crescenzo, A.; SHiP Collaboration

2016-01-01

SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently submitted to the CERN SPS Committee. In its initial phase, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5years. A dedicated detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. Another dedicated detector, based on the Emulsion Cloud Chamber technology already used in the OPERA experiment, will allow to perform for the first time measurements of the tau neutrino deep inelastic scattering cross section. Tau neutrinos will be distinguished from tau anti-neutrinos, thus providing the first observation of the tau anti-neutrino.

The Nike KrF laser facility: Performance and initial target experiments

NASA Astrophysics Data System (ADS)

Obenschain, S. P.; Bodner, S. E.; Colombant, D.; Gerber, K.; Lehmberg, R. H.; McLean, E. A.; Mostovych, A. N.; Pronko, M. S.; Pawley, C. J.; Schmitt, A. J.; Sethian, J. D.; Serlin, V.; Stamper, J. A.; Sullivan, C. A.; Dahlburg, J. P.; Gardner, J. H.; Chan, Y.; Deniz, A. V.; Hardgrove, J.; Lehecka, T.; Klapisch, M.

1996-05-01

Krypton-fluoride (KrF) lasers are of interest to laser fusion because they have both the large bandwidth capability (≳THz) desired for rapid beam smoothing and the short laser wavelength (1/4 μm) needed for good laser-target coupling. Nike is a recently completed 56-beam KrF laser and target facility at the Naval Research Laboratory. Because of its bandwidth of 1 THz FWHM (full width at half-maximum), Nike produces more uniform focal distributions than any other high-energy ultraviolet laser. Nike was designed to study the hydrodynamic instability of ablatively accelerated planar targets. First results show that Nike has spatially uniform ablation pressures (Δp/p<2%). Targets have been accelerated for distances sufficient to study hydrodynamic instability while maintaining good planarity. In this review we present the performance of the Nike laser in producing uniform illumination, and its performance in correspondingly uniform acceleration of targets.

48 CFR 215.404-71-4 - Facilities capital employed.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Facilities capital employed. 215.404-71-4 Section 215.404-71-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION...

Experiment Needs and Facilities Study Appendix A Transient Reactor Test Facility (TREAT) Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The TREAT Upgrade effort is designed to provide significant new capabilities to satisfy experiment requirements associated with key LMFBR Safety Issues. The upgrade consists of reactor-core modifications to supply the physics performance needed for the new experiments, an Advanced TREAT loop with size and thermal-hydraulics capabilities needed for the experiments, associated interface equipment for loop operations and handling, and facility modifications necessary to accommodate operations with the Loop. The costs and schedules of the tasks to be accomplished under the TREAT Upgrade project are summarized. Cost, including contingency, is about 10 million dollars (1976 dollars). A schedule for execution ofmore » 36 months has been established to provide the new capabilities in order to provide timely support of the LMFBR national effort. A key requirement for the facility modifications is that the reactor availability will not be interrupted for more than 12 weeks during the upgrade. The Advanced TREAT loop is the prototype for the STF small-bundle package loop. Modified TREAT fuel elements contain segments of graphite-matrix fuel with graded uranium loadings similar to those of STF. In addition, the TREAT upgrade provides for use of STF-like stainless steel-UO{sub 2} TREAT fuel for tests of fully enriched fuel bundles. This report will introduce the Upgrade study by presenting a brief description of the scope, performance capability, safety considerations, cost schedule, and development requirements. This work is followed by a "Design Description". Because greatly upgraded loop performance is central to the upgrade, a description is given of Advanced TREAT loop requirements prior to description of the loop concept. Performance requirements of the upgraded reactor system are given. An extensive discussion of the reactor physics calculations performed for the Upgrade concept study is provided. Adequate physics performance is essential for performance of experiments

NAD(P)H:Flavin Mononucleotide Oxidoreductase Inactivation during 2,4,6-Trinitrotoluene Reduction

PubMed Central

Riefler, R. Guy; Smets, Barth F.

2002-01-01

Bacteria readily transform 2,4,6-trinitrotoluene (TNT), a contaminant frequently found at military bases and munitions production facilities, by reduction of the nitro group substituents. In this work, the kinetics of nitroreduction were investigated by using a model nitroreductase, NAD(P)H:flavin mononucleotide (FMN) oxidoreductase. Under mediation by NAD(P)H:FMN oxidoreductase, TNT rapidly reacted with NADH to form 2-hydroxylamino-4,6-dinitrotoluene and 4-hydroxylamino-2,6-dinitrotoluene, whereas 2-amino-4,6-dinitrotoluene and 4-amino-2,6-dinitrotoluene were not produced. Progressive loss of activity was observed during TNT reduction, indicating inactivation of the enzyme during transformation. It is likely that a nitrosodinitrotoluene intermediate reacted with the NAD(P)H:FMN oxidoreductase, leading to enzyme inactivation. A half-maximum constant with respect to NADH, KN, of 394 μM was measured, indicating possible NADH limitation under typical cellular conditions. A mathematical model that describes the inactivation process and NADH limitation provided a good fit to TNT reduction profiles. This work represents the first step in developing a comprehensive enzyme level understanding of nitroarene biotransformation. PMID:11916686

Test Facilities and Experience on Space Nuclear System Developments at the Kurchatov Institute

NASA Astrophysics Data System (ADS)

Ponomarev-Stepnoi, Nikolai N.; Garin, Vladimir P.; Glushkov, Evgeny S.; Kompaniets, George V.; Kukharkin, Nikolai E.; Madeev, Vicktor G.; Papin, Vladimir K.; Polyakov, Dmitry N.; Stepennov, Boris S.; Tchuniyaev, Yevgeny I.; Tikhonov, Lev Ya.; Uksusov, Yevgeny I.

2004-02-01

The complexity of space fission systems and rigidity of requirement on minimization of weight and dimension characteristics along with the wish to decrease expenditures on their development demand implementation of experimental works which results shall be used in designing, safety substantiation, and licensing procedures. Experimental facilities are intended to solve the following tasks: obtainment of benchmark data for computer code validations, substantiation of design solutions when computational efforts are too expensive, quality control in a production process, and ``iron'' substantiation of criticality safety design solutions for licensing and public relations. The NARCISS and ISKRA critical facilities and unique ORM facility on shielding investigations at the operating OR nuclear research reactor were created in the Kurchatov Institute to solve the mentioned tasks. The range of activities performed at these facilities within the implementation of the previous Russian nuclear power system programs is briefly described in the paper. This experience shall be analyzed in terms of methodological approach to development of future space nuclear systems (this analysis is beyond this paper). Because of the availability of these facilities for experiments, the brief description of their critical assemblies and characteristics is given in this paper.

SHiP: a new multipurpose beam-dump experiment at the SPS

NASA Astrophysics Data System (ADS)

Dijkstra, H. B.

2016-11-01

SHiP is an experiment to look for very weakly interacting particles at a new to be constructed beam-dump facility at the CERN SPS. The SHiP Technical Proposal has been submitted to the CERN SPS Committee in April 2015. The 400 GeV/c proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 × 1020 proton on target in five years. A detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutral Leptons (HNL). The sensitivity to HNL will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. Integrated in SHiP is an Emulsion Cloud Chamber, already used in the OPERA experiment, which will allow to study active neutrino cross-sections and angular distributions. In particular SHiP can distinguish between vτ and v¯τ, and their deep inelastic scattering cross sections will be measured with statistics three orders of magnitude larger than currently available.

Hohlraum modeling for opacity experiments on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Dodd, E. S.; DeVolder, B. G.; Martin, M. E.; Krasheninnikova, N. S.; Tregillis, I. L.; Perry, T. S.; Heeter, R. F.; Opachich, Y. P.; Moore, A. S.; Kline, J. L.; Johns, H. M.; Liedahl, D. A.; Cardenas, T.; Olson, R. E.; Wilde, B. H.; Urbatsch, T. J.

2018-06-01

This paper discusses the modeling of experiments that measure iron opacity in local thermodynamic equilibrium (LTE) using laser-driven hohlraums at the National Ignition Facility (NIF). A previous set of experiments fielded at Sandia's Z facility [Bailey et al., Nature 517, 56 (2015)] have shown up to factors of two discrepancies between the theory and experiment, casting doubt on the validity of the opacity models. The purpose of the new experiments is to make corroborating measurements at the same densities and temperatures, with the initial measurements made at a temperature of 160 eV and an electron density of 0.7 × 1022 cm-3. The X-ray hot spots of a laser-driven hohlraum are not in LTE, and the iron must be shielded from a direct line-of-sight to obtain the data [Perry et al., Phys. Rev. B 54, 5617 (1996)]. This shielding is provided either with the internal structure (e.g., baffles) or external wall shapes that divide the hohlraum into a laser-heated portion and an LTE portion. In contrast, most inertial confinement fusion hohlraums are simple cylinders lacking complex gold walls, and the design codes are not typically applied to targets like those for the opacity experiments. We will discuss the initial basis for the modeling using LASNEX, and the subsequent modeling of five different hohlraum geometries that have been fielded on the NIF to date. This includes a comparison of calculated and measured radiation temperatures.

Facility Volume and Survival in Nasopharyngeal Carcinoma.

PubMed

Yoshida, Emi J; Luu, Michael; David, John M; Kim, Sungjin; Mita, Alain; Scher, Kevin; Shiao, Stephen L; Tighiouart, Mourad; Lee, Nancy Y; Ho, Allen S; Zumsteg, Zachary S

2018-02-01

Definitive treatment of nasopharyngeal carcinoma (NPC) is challenging owing to its rarity, complicated regional anatomy, and the intensity of therapy. In contrast to other head and neck cancers, the effect of facility volume has not been well described for NPC. The National Cancer Database was queried for patients with stage II-IVB NPC diagnosed from 2004 to 2014 and treated with definitive radiation. Patients with incomplete staging, unknown receipt or timing of treatment, unknown follow-up duration, incomplete socioeconomic information, or treatment outside the reporting facility were excluded. High-volume facilities (HVFs) were defined as the top 5% of facilities according to the annual facility volume. The present analysis included 3941 NPC patients treated at 804 facilities with a median follow-up duration of 59.4 months, including 1025 patients (26.0%) treated at HVFs. Treatment at HVFs was associated with significantly improved overall survival (OS) on multivariable analysis (hazard ratio 0.79, 95% confidence interval 0.69-0.90; P=.001). In propensity score-matched cohorts, 5-year OS was 69.1% versus 63.3% at HVFs versus lower volume facilities (LVFs), respectively (P=.003). Similar results were seen when facility volume was analyzed as a continuous variable. The effect of facility volume on survival varied by academic status (P=.002 for interaction). At academic centers, the propensity score-matched cohorts had 5-year OS of 71.4% compared with 62.4% (P<.001) at HVFs and LVFs, respectively. In contrast, the 5-year OS was 63.5% versus 67.9% (P=.68) in propensity score-matched patients at nonacademic HVFs and LVFs. Treatment at HVFs was associated with improved OS for patients with NPC, with the effect exclusively seen at academic centers. Copyright © 2017 Elsevier Inc. All rights reserved.

Patient Care Staffing Levels and Facility Characteristics in U.S. Hemodialysis Facilities

PubMed Central

Yoder, Laura A. G.; Xin, Wenjun; Norris, Keith C.; Yan, Guofen

2013-01-01

Background Higher numbers of registered nurses per patient have been associated with improved patient outcomes in acute care facilities. Variation and associations of patient-care staffing levels and hemodialysis facility characteristics have not been previously examined. Study Design Cross-sectional study using Poisson regression to examine associations betwee patient-care staffing levels and hemodialysis facility characteristics. Setting & Participants 4,800 U.S. hemodialysis facilities in the 2009 CMS ESRD Annual Facility Survey (CMS-2744), USRDS. Predictors Facility characteristics, including profit status, freestanding status, chain affiliatio and geographic region, adjusted for facility size, capacity, functional type, and urbanicity. Outcomes Patient care staffing levels, including ratios of Registered Nurses (RN), Licensed Practical Nurses (LPN), Patient Care Technicians (PCT), composite staff (RN+LPN+PCT), Social Workers, and Dietitians to in-center hemodialysis patients. Results After adjusting for background facility characteristics, the ratios of RNs and LPNs to patients were 35% (p<0.001) and 42% (p<0.001) lower, but the PCT-to-patient ratio was 16% (p<0.001) higher in for-profit facilities than those in nonprofit facilities (Rate ratio, 0.65, 95%CI, 0.63–0.68; 0.58, 0.51–0.65; 1.16, 1.12–1.19; respectively). Regionally, compared to the Northeast, the adjusted RN-to-patient ratio was 14% (p< 0.001) lower in the Midwest, 25% (p< 0.001) lower in the South, and 18% (p< 0.001) lower in the West. Even after additional adjustments, the large for-profit chains had significantly lower RN and LPN ratios than the largest nonprofit chain, but a significantly higher PCT-to-patient ratio. The overall composite staffing levels were also lower in for-profit and chain-affiliated facilities. The patterns hold when the hospital-based units were excluded. Limitations Nursing hours were not available. Conclusions The significant variation in patient-care staffing

32 CFR 809a.4 - Use of Government facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Use of Government facilities. 809a.4 Section 809a.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION... in interference with, or prevention of, the orderly accomplishment of the mission of an installation...

32 CFR 809a.4 - Use of Government facilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Use of Government facilities. 809a.4 Section 809a.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION... in interference with, or prevention of, the orderly accomplishment of the mission of an installation...

32 CFR 809a.4 - Use of Government facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Use of Government facilities. 809a.4 Section 809a.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION... in interference with, or prevention of, the orderly accomplishment of the mission of an installation...

32 CFR 809a.4 - Use of Government facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Use of Government facilities. 809a.4 Section 809a.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION... in interference with, or prevention of, the orderly accomplishment of the mission of an installation...

32 CFR 809a.4 - Use of Government facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Use of Government facilities. 809a.4 Section 809a.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ADMINISTRATION... in interference with, or prevention of, the orderly accomplishment of the mission of an installation...

Simulation of Containment Atmosphere Mixing and Stratification Experiment in the ThAI Facility with a CFD Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babic, Miroslav; Kljenak, Ivo; Mavko, Borut

2006-07-01

The CFD code CFX4.4 was used to simulate an experiment in the ThAI facility, which was designed for investigation of thermal-hydraulic processes during a severe accident inside a Light Water Reactor containment. In the considered experiment, air was initially present in the vessel, and helium and steam were injected during different phases of the experiment at various mass flow rates and at different locations. The main purpose of the proposed work was to assess the capabilities of the CFD code to reproduce the atmosphere structure with a three-dimensional model, coupled with condensation models proposed by the authors. A three-dimensional modelmore » of the ThAI vessel for the CFX4.4 code was developed. The flow in the simulation domain was modeled as single-phase. Steam condensation on vessel walls was modeled as a sink of mass and energy using a correlation that was originally developed for an integral approach. A simple model of bulk phase change was also included. Calculated time-dependent variables together with temperature and volume fraction distributions at the end of different experiment phases are compared to experimental results. (authors)« less

Gas-Grain Simulation Facility: Fundamental studies of particle formation and interactions. Volume 2: Abstracts, candidate experiments and feasibility study

NASA Technical Reports Server (NTRS)

Fogleman, Guy (Editor); Huntington, Judith L. (Editor); Schwartz, Deborah E. (Editor); Fonda, Mark L. (Editor)

1989-01-01

An overview of the Gas-Grain Simulation Facility (GGSF) project and its current status is provided. The proceedings of the Gas-Grain Simulation Facility Experiments Workshop are recorded. The goal of the workshop was to define experiments for the GGSF--a small particle microgravity research facility. The workshop addressed the opportunity for performing, in Earth orbit, a wide variety of experiments that involve single small particles (grains) or clouds of particles. Twenty experiments from the fields of exobiology, planetary science, astrophysics, atmospheric science, biology, physics, and chemistry were described at the workshop and are outlined in Volume 2. Each experiment description included specific scientific objectives, an outline of the experimental procedure, and the anticipated GGSF performance requirements. Since these experiments represent the types of studies that will ultimately be proposed for the facility, they will be used to define the general science requirements of the GGSF. Also included in the second volume is a physics feasibility study and abstracts of example Gas-Grain Simulation Facility experiments and related experiments in progress.

10 CFR 4.550 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE COMMISSION Enforcement of Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the U.S. Nuclear Regulatory Commission § 4.550 Program accessibility: Existing facilities. (a) General. The agency shall operate each program or activity...

The response of physician groups to P4P incentives.

PubMed

Mehrotra, Ateev; Pearson, Steven D; Coltin, Kathryn L; Kleinman, Ken P; Singer, Janice A; Rabson, Barbra; Schneider, Eric C

2007-05-01

Despite substantial enthusiasm among insurers and federal policy makers for pay-for-performance incentives, little is known about the current scope of these incentives or their influence on the delivery of care. To assess the scope and magnitude of pay-for-performance (P4P) incentives among physician groups and to examine whether such incentives are associated with quality improvement initiatives. Structured telephone survey of leaders of physician groups delivering primary care in Massachusetts. ASSESSED METHODS: Prevalence of P4P incentives among physician groups tied to specific measures of quality or utilization and prevalence of physician group quality improvement initiatives. Most group leaders (89%) reported P4P incentives in at least 1 commercial health plan contract. Incentives were tied to performance on Health Employer Data and Information Set (HEDIS) quality measures (89% of all groups), utilization measures (66%), use of information technology (52%), and patient satisfaction (37%). Among the groups with P4P and knowledge of all revenue streams, the incentives accounted for 2.2% (range, 0.3%-8.8%) of revenue. P4P incentives tied to HEDIS quality measures were positively associated with groups' quality improvement initiatives (odds ratio, 1.6; P = .02). Thirty-six percent of group leaders with P4P incentives reported that they were very important or moderately important to the group's financial success. P4P incentives are now common among physician groups in Massachusetts, and these incentives most commonly reward higher clinical quality or lower utilization of care. Although the scope and magnitude of incentives are still modest for many groups, we found an association between P4P incentives and the use of quality improvement initiatives.

Materials Science Experiments Under Microgravity - A Review of History, Facilities, and Future Opportunities

NASA Technical Reports Server (NTRS)

Stenzel, Ch.

2012-01-01

Materials science experiments have been a key issue already since the early days of research under microgravity conditions. A microgravity environment facilitates processing of metallic and semiconductor melts without buoyancy driven convection and sedimentation. Hence, crystal growth of semiconductors, solidification of metallic alloys, and the measurement of thermo-physical parameters are the major applications in the field of materials science making use of these dedicated conditions in space. In the last three decades a large number of successful experiments have been performed, mainly in international collaborations. In parallel, the development of high-performance research facilities and the technological upgrade of diagnostic and stimuli elements have also contributed to providing optimum conditions to perform such experiments. A review of the history of materials science experiments in space focussing on the development of research facilities is given. Furthermore, current opportunities to perform such experiments onboard ISS are described and potential future options are outlined.

Trends in family ratings of experience with care and racial disparities among Maryland nursing homes.

PubMed

Li, Yue; Ye, Zhiqiu; Glance, Laurent G; Temkin-Greener, Helena

2014-07-01

Providing equitable and patient-centered care is critical to ensuring high quality of care. Although racial/ethnic disparities in quality are widely reported for nursing facilities, it is unknown whether disparities exist in consumer experiences with care and how public reporting of consumer experiences affects facility performance and potential racial disparities. We analyzed trends of consumer ratings publicly reported for Maryland nursing homes during 2007-2010, and determined whether racial/ethnic disparities in experiences with care changed during this period. Multivariate longitudinal regression models controlled for important facility and county characteristics and tested changes overall and by facility groups (defined based on concentrations of black residents). Consumer ratings were reported for: overall care; recommendation of the facility; staff performance; care provided; food and meals; physical environment; and autonomy and personal rights. Overall ratings on care experience remained relatively high (mean=8.3 on a 1-10 scale) during 2007-2010. Ninety percent of survey respondents each year would recommend the facility to someone who needs nursing home care. Ratings on individual domains of care improved among all nursing homes in Maryland (P<0.01), except for food and meals (P=0.827 for trend). However, site-of-care disparities existed in each year for overall ratings, recommendation rate, and ratings on all domains of care (P<0.01 in all cases), with facilities more predominated by black residents having lower scores; such disparities persisted over time (P>0.2 for trends in disparities). Although Maryland nursing homes showed maintained or improved consumer ratings during the first 4 years of public reporting, gaps persisted between facilities with high versus low concentrations of minority residents.

Onboard experiment data support facility, task 1 report. [space shuttles

NASA Technical Reports Server (NTRS)

1975-01-01

The conceptual design and specifications are developed for an onboard experiment data support facility (OEDSF) to provide end to end processing of data from various payloads on board space shuttles. Classical data processing requirements are defined and modeled. Onboard processing requirements are analyzed. Specifications are included for an onboard processor.

The Boiling eXperiment Facility (BXF) for the Microgravity Science Glovebox (MSG)

NASA Technical Reports Server (NTRS)

McQuillen, John; Chao, David; Vergilii, Frank

2006-01-01

Boiling is an effective means of cooling by removing heat from surfaces through vaporization of a working fluid. It is also affected by both the magnitude and direction of gravity. By conducting pool boiling tests in microgravity, the effect of buoyancy n the overall boiling process and the relative magnitude of other phenomena can be assessed. The Boiling eXperiment Facility (BXF) is being built for the Microgravity Science Glovebox. This facility will conduct two pool boiling studies. The first study the Microheater Array Boiling Experiment (MABE) uses two 96 element microheater arrays, 2.7 mm and 7.0 mm in size, to measure localized hear fluxes while operating at a constant temperature. The other experiment, the Nucleate Pool Boiling eXperiment (NPBX) uses a 85 mm diameter heater wafer that has been "seeded" with five individually-controlled nucleation sites to study bubble nucleation, growth, coalescence and departure. The BXF uses normal-perfluorohexane as the test fluid and will operate between pressures of 60 to 244 Pa. and temperatures of 35 to 60 C. Both sets of experimental heaters are highly instrumented. Pressure and bulk fluid temperature measurements will be made with standard rate video. A high speed video system will be used to visualize the boiling process through the bottom of the MABE heater arrays. The BXF is currently scheduled to fly on Utilization Flight-13A.1 to the ISS with facility integration into the MSG and operation during Increment 15

Investigation of X-ray lasers on the SOKOL-P facility at RFNC-VNIITF

NASA Astrophysics Data System (ADS)

Gavrilov, D. S.; Andriyash, A. V.; Vikhlyaev, D. A.; Gorokhov, S. A.; Dmitrov, D. A.; Zapysov, A. L.; Kakshin, A. G.; Kapustin, I. A.; Loboda, E. A.; Lykov, V. A.; Politov, V. Yu.; Potapov, A. V.; Pronin, V. A.; Rykovanov, G. N.; Sukhanov, V. N.; Tischenko, A. S.; Ugodenko, A. A.; Chefonov, O. V.

2007-11-01

The experiments [1] have demonstrated generation of the laser X-radiation (LXR) λ=326A on 3p-3s transitions of Ne-like Ti ions at sequential irradiation of the targets by two laser pulses, focused into a narrow line. The small signal gain equaled 30cm-1. The intensity was 0.5.10^12 W/cm^2 in the prepulse of 0.4ns and 10^14 W/cm^2 in the master pulse of 4ps (delay 1.5 ns). The dependence of LXR yield on the laser energy is demonstrated to have an exponential form. The traveling pumping wave mode was realized using the reflective echelon and the LXR yield is as great as 5-fold. The latest experiments have demonstrated the LXR generation on 4d-4p of Ni-like molybdenum λ=189A. The development of LXR generation model, and numerical codes which allow for the quanta delay effects, quanta refraction in plasma with heavy density gradient, and also the saturation effect have made it possible to describe the experimental dependence of the output LXR yield on the active medium length. Good quantitative agreement is also evident when estimating the output LXR yield on Ne-like Ti ions. [1]Andriyash Quantum Electronics 36 511

Glovebox in orbit - ESA/NASA Glovebox: A versatile USML-1 experiment facility

NASA Technical Reports Server (NTRS)

Sutherland, Ian A.; Wolff, Heinz; Helmke, Hartmut; Riesselmann, Werner; Nagy, Mike; Voeten, Eduard; Chassay, Roger

1993-01-01

The general purpose experiment facility flown aboard Space Shuttle USML-1 and known as the Glovebox is briefly discussed. Glovebox enabled scientists to perform materials science, fluids, and combustion experiments safely without contaminating the closed environment of Spacelab and endangering the crew. The evolution of Glovebox, its special features, and its hardware are described. The Glovebox experiments are summarized along with postmission and crew debriefing. Future uses of Glovebox are discussed.

42 CFR 9.4 - Physical facility policies and design.

Code of Federal Regulations, 2012 CFR

2012-10-01

... conditioning (HVAC); food preparation area; and animal waste treatment. (2) A housing system shall include... STANDARDS OF CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.4 Physical facility...

42 CFR 9.4 - Physical facility policies and design.

Code of Federal Regulations, 2014 CFR

2014-10-01

... conditioning (HVAC); food preparation area; and animal waste treatment. (2) A housing system shall include... STANDARDS OF CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.4 Physical facility...

42 CFR 9.4 - Physical facility policies and design.

Code of Federal Regulations, 2013 CFR

2013-10-01

... conditioning (HVAC); food preparation area; and animal waste treatment. (2) A housing system shall include... STANDARDS OF CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.4 Physical facility...

42 CFR 9.4 - Physical facility policies and design.

Code of Federal Regulations, 2011 CFR

2011-10-01

... conditioning (HVAC); food preparation area; and animal waste treatment. (2) A housing system shall include... STANDARDS OF CARE FOR CHIMPANZEES HELD IN THE FEDERALLY SUPPORTED SANCTUARY SYSTEM § 9.4 Physical facility...

5 CFR 1631.4 - Public reference facilities and current index.

Code of Federal Regulations, 2010 CFR

2010-01-01

... index. 1631.4 Section 1631.4 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD AVAILABILITY OF RECORDS Production or Disclosure of Records Under the Freedom of Information Act, 5 U.S.C. 552 § 1631.4 Public reference facilities and current index. (a) The Board maintains a public reading area...

15 CFR Appendix A to Part 4 - Freedom of Information Public Inspection Facilities, and Addresses for Requests for Records Under...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Freedom of Information Public... Commerce and Foreign Trade Office of the Secretary of Commerce DISCLOSURE OF GOVERNMENT INFORMATION Pt. 4... Saturdays, Sundays, and legal public holidays) between 9 a.m. and 4 p.m. local time of the facility at issue...

First experiment on LMJ facility: pointing and synchronisation qualification, sequences qualification

NASA Astrophysics Data System (ADS)

Henry, Olivier; Raffestin, Didier; Bretheau, Dominique; Luttmann, Michel; Graillot, Herve; Ferri, Michel; Seguineau, Frederic; Bar, Emmanuel; Patissou, Loic; Canal, Philippe; Sautarel, Françoise; Tranquille-Marques, Yves

2015-11-01

The LMJ (Laser mega Joule) facility at the CESTA site (Aquitaine, France) is a tool designed to deliver up to 1.2 MJ at 351 nm. The experiment system will include plasma diagnostics: UV and X energy balances, imagers (Streak and stripe camera, CCD), spectrometers, and a Visar/pyrometer. The facility must be able to deliver, within the hour following the shot, all the results of the plasma diagnostics, alignment images and laser diagnostic measurements. Part of the end of 2014 was devoted to the qualification of system pointing on target and synchronization within and between beams. The shots made with one chain (divided in 2 quads - 8 laser beams) have achieved 50 μm of misalignment accuracy and a synchronization accuracy in the order of 50 ps. The performances achieved for plasma diagnostic (in the order of less 100 μm of alignment and timing accuracy less than 150 ps) comply with expectations. At the same time the first automatic sequences were tested. They allowed a shot on target every 6h:30 and in some case twice a day by reducing preparation actions, leading to a sequence of 4h:00. These shooting sequences are managed by an operating team of 7 people helped by 3 people for security aspects.

Numerical simulation of experiments in the Giant Planet Facility

NASA Technical Reports Server (NTRS)

Green, M. J.; Davy, W. C.

1979-01-01

Utilizing a series of existing computer codes, ablation experiments in the Giant Planet Facility are numerically simulated. Of primary importance is the simulation of the low Mach number shock layer that envelops the test model. The RASLE shock-layer code, used in the Jupiter entry probe heat-shield design, is adapted to the experimental conditions. RASLE predictions for radiative and convective heat fluxes are in good agreement with calorimeter measurements. In simulating carbonaceous ablation experiments, the RASLE code is coupled directly with the CMA material response code. For the graphite models, predicted and measured recessions agree very well. Predicted recession for the carbon phenolic models is 50% higher than that measured. This is the first time codes used for the Jupiter probe design have been compared with experiments.

The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression

PubMed Central

Wang, Weibin; Pan, Kewu; Chen, Yifan; Huang, Chunyin; Zhang, Xiaowei

2012-01-01

HBP1 is a sequence-specific DNA-binding transcription factor with many important biological roles. It activates or represses the expression of some specific genes during cell growth and differentiation. Previous studies have exhibited that HBP1 binds to p16INK4A promoter and activates p16INK4A expression. We found that trichostatin A (TSA), an inhibitor of HDAC (histone deacetylase), induces p16INK4A expression in an HBP1-dependent manner. This result was drawn from a transactivation experiment by measuring relative luciferase activities of p16INK4A promoter with HBP1-binding site in comparison with that of the wild-type p16INK4A promoter by transient cotransfection with HBP1 into HEK293T cells and 2BS cells. HBP1 acetylation after TSA treatment was confirmed by immunoprecipitation assay. Our data showed that HBP1 interacted with histone acetyltransferase p300 and CREB-binding protein (CBP) and also recruited p300/CBP to p16INK4A promoter. HBP1 was acetylated by p300/CBP in two regions: repression domain (K297/305/307) and P domain (K171/419). Acetylation of Repression domain was not required for HBP1 transactivation on p16INK4A. However, luciferase assay and western blotting results indicate that acetylation of P domain, especially K419 acetylation is essential for HBP1 transactivation on p16INK4A. As assayed by SA-beta-gal staining, the acetylation of HBP1 at K419 enhanced HBP1-induced premature senescence in 2BS cells. In addition, HDAC4 repressed HBP1-induced premature senescence through permanently deacetylating HBP1. We conclude that our data suggest that HBP1 acetylation at K419 plays an important role in HBP1-induced p16INK4A expression. PMID:21967847

Ion traps for precision experiments at rare-isotope-beam facilities

NASA Astrophysics Data System (ADS)

Kwiatkowski, Anna

2016-09-01

Ion traps first entered experimental nuclear physics when the ISOLTRAP team demonstrated Penning trap mass spectrometry of radionuclides. From then on, the demand for ion traps has grown at radioactive-ion-beam (RIB) facilities since beams can be tailored for the desired experiment. Ion traps have been deployed for beam preparation, from bunching (thereby allowing time coincidences) to beam purification. Isomerically pure beams needed for nuclear-structure investigations can be prepared for trap-assisted or in-trap decay spectroscopy. The latter permits studies of highly charged ions for stellar evolution, which would be impossible with traditional experimental nuclear-physics methods. Moreover, the textbook-like conditions and advanced ion manipulation - even of a single ion - permit high-precision experiments. Consequently, the most accurate and precise mass measurements are now performed in Penning traps. After a brief introduction to ion trapping, I will focus on examples which showcase the versatility and utility of the technique at RIB facilities. I will demonstrate how this atomic-physics technique has been integrated into nuclear science, accelerator physics, and chemistry. DOE.

Novel β-C3N4/CuO nanoflakes: facile synthesis and unique photocatalytic performance

NASA Astrophysics Data System (ADS)

Zou, Lan-Rong; Huang, Gui-Fang; Li, Dong-Feng; Tian, Qing-Nan; Yang, Ke; Si, Yuan; Chang, Shengli; Zhang, Xue-Ao; Huang, Wei-Qing

2017-09-01

For the first time, novel β-C3N4/CuO composites with superior photocatalytic activity are successfully fabricated via a facile reflux method followed by a thermal process. The morphologies, particle size and microstructure of the synthesized β-C3N4/CuO composites largely depended upon copper chloride and the volume ratio of V water:V ethanol in the mixed precursors. The fabricated β-C3N4/CuO nanoflakes exhibited obviously enhanced visible light photocatalytic activity for the degradation of methylene blue (MB) with an  ˜3.4 and 1.9 fold increase in efficiency over that of pure g-C3N4 and commercial P25, respectively. The β-C3N4/CuO composite photocatalyst also showed photocatalytic activity for the degradation of methyl orange (MO). Moreover, the β-C3N4/CuO nanoflakes showed almost no loss of photocatalytic activity after three recycles of the degradation of the MB. A multiple synergetic mechanism in β-C3N4/CuO nanoflakes, which is featured by the highly reactive {0 0 2} facets, exposed many active sites of nanoflakes and the efficient charge separation are proposed to account for the distinguished photocatalytic activity. This work provides a facile and cost-effective strategy for designing novel β-C3N4/CuO photocatalysts for application in environmental purification.

48 CFR 222.101-4 - Removal of items from contractors' facilities affected by work stoppages.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contractors' facilities affected by work stoppages. 222.101-4 Section 222.101-4 Federal Acquisition... contractors' facilities affected by work stoppages. (a) When a contractor is unable to deliver urgent and critical items because of a work stoppage at its facility, the contracting officer, before removing any...

Characterization of the TIP4P-Ew water model: vapor pressure and boiling point.

PubMed

Horn, Hans W; Swope, William C; Pitera, Jed W

2005-11-15

The liquid-vapor-phase equilibrium properties of the previously developed TIP4P-Ew water model have been studied using thermodynamic integration free-energy simulation techniques in the temperature range of 274-400 K. We stress that free-energy results from simulations need to be corrected in order to be compared to the experiment. This is due to the fact that the thermodynamic end states accessible through simulations correspond to fictitious substances (classical rigid liquids and classical rigid ideal gases) while experiments operate on real substances (liquids and real gases, with quantum effects). After applying analytical corrections the vapor pressure curve obtained from simulated free-energy changes is in excellent agreement with the experimental vapor pressure curve. The boiling point of TIP4P-Ew water under ambient pressure is found to be at 370.3+/-1.9 K, about 7 K higher than the boiling point of TIP4P water (363.7+/-5.1 K; from simulations that employ finite range treatment of electrostatic and Lennard-Jones interactions). This is in contrast to the approximately +15 K by which the temperature of the density maximum and the melting temperature of TIP4P-Ew are shifted relative to TIP4P, indicating that the temperature range over which the liquid phase of TIP4P-Ew is stable is narrower than that of TIP4P and resembles more that of real water. The quality of the vapor pressure results highlights the success of TIP4P-Ew in describing the energetic and entropic aspects of intermolecular interactions in liquid water.

Collaborative Occupational Therapy: Teachers' Impressions of the Partnering for Change (P4C) Model.

PubMed

Wilson, A L; Harris, S R

2018-05-01

Occupational therapists (OTs) often face barriers when trying to collaborate with teachers in school-based settings. Partnering for change (P4C), a collaborative practice model designed to support children with developmental coordination disorder, could potentially support all students with special needs. Therefore, the aim of this study was to explore how teachers experience OT services delivered using the P4C model to support children with a variety of special needs. P4C was implemented at one elementary school in Courtenay, British Columbia. Eleven teachers participated in two focus groups and a one-on-one interview to gather descriptive, qualitative data. Grounded theory techniques were used for data analysis. Four themes (collaborating in the thick of it all, learning and taking risks, managing limited time and resources, and appreciating responsive OT support) represented teachers' experiences of P4C. Teachers strongly preferred collaborative OT services based on the P4C model. Students with a variety of special needs were supported within their classrooms as teachers learned new strategies from the OT and found ways to embed these strategies into their daily routines.

Experience with a UNIX based batch computing facility for H1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerhards, R.; Kruener-Marquis, U.; Szkutnik, Z.

1994-12-31

A UNIX based batch computing facility for the H1 experiment at DESY is described. The ultimate goal is to replace the DESY IBM mainframe by a multiprocessor SGI Challenge series computer, using the UNIX operating system, for most of the computing tasks in H1.

Mobile/Modular BSL-4 Facilities for Meeting Restricted Earth Return Containment Requirements

NASA Technical Reports Server (NTRS)

Calaway, M. J.; McCubbin, F. M.; Allton, J. H.; Zeigler, R. A.; Pace, L. F.

2017-01-01

NASA robotic sample return missions designated Category V Restricted Earth Return by the NASA Planetary Protection Office require sample containment and biohazard testing in a receiving laboratory as directed by NASA Procedural Requirement (NPR) 8020.12D - ensuring the preservation and protection of Earth and the sample. Currently, NPR 8020.12D classifies Restricted Earth Return for robotic sample return missions from Mars, Europa, and Enceladus with the caveat that future proposed mission locations could be added or restrictions lifted on a case by case basis as scientific knowledge and understanding of biohazards progresses. Since the 1960s, sample containment from an unknown extraterrestrial biohazard have been related to the highest containment standards and protocols known to modern science. Today, Biosafety Level (BSL) 4 standards and protocols are used to study the most dangerous high-risk diseases and unknown biological agents on Earth. Over 30 BSL-4 facilities have been constructed worldwide with 12 residing in the United States; of theses, 8 are operational. In the last two decades, these brick and mortar facilities have cost in the hundreds of millions of dollars dependent on the facility requirements and size. Previous mission concept studies for constructing a NASA sample receiving facility with an integrated BSL-4 quarantine and biohazard testing facility have also been estimated in the hundreds of millions of dollars. As an alternative option, we have recently conducted an initial trade study for constructing a mobile and/or modular sample containment laboratory that would meet all BSL-4 and planetary protection standards and protocols at a faction of the cost. Mobile and modular BSL-2 and 3 facilities have been successfully constructed and deployed world-wide for government testing of pathogens and pharmaceutical production. Our study showed that a modular BSL-4 construction could result in approximately 90% cost reduction when compared to

US EPA Region 4 RMP Facilities

EPA Pesticide Factsheets

To improve public health and the environment, the United States Environmental Protection Agency (USEPA) collects information about facilities, sites, or places subject to environmental regulation or of environmental interest. Through the Geospatial Data Download Service, the public is now able to download the EPA Geodata shapefile containing facility and site information from EPA's national program systems. The file is Internet accessible from the Envirofacts Web site (http://www.epa.gov/enviro). The data may be used with geospatial mapping applications. (Note: The shapefile omits facilities without latitude/longitude coordinates.) The EPA Geospatial Data contains the name, location (latitude/longitude), and EPA program information about specific facilities and sites. In addition, the file contains a Uniform Resource Locator (URL), which allows mapping applications to present an option to users to access additional EPA data resources on a specific facility or site.

Communication: Direct comparison between theory and experiment for correlated angular and product-state distributions of the ground-state and stretching-excited O(3P) + CH4 reactions

NASA Astrophysics Data System (ADS)

Czakó, Gábor

2014-06-01

Motivated by a recent experiment [H. Pan and K. Liu, J. Chem. Phys. 140, 191101 (2014)], we report a quasiclassical trajectory study of the O(3P) + CH4(vk = 0, 1) → OH + CH3 [k = 1 and 3] reactions on an ab initio potential energy surface. The computed angular distributions and cross sections correlated to the OH(v = 0, 1) + CH3(v = 0) coincident product states can be directly compared to experiment for O + CH4(v3 = 0, 1). Both theory and experiment show that the ground-state reaction is backward scattered, whereas the angular distributions shift toward sideways and forward directions upon antisymmetric stretching (v3) excitation of the reactant. Theory predicts similar behavior for the O + CH4(v1 = 1) reaction. The simulations show that stretching excitation enhances the reaction up to about 15 kcal/mol collision energy, whereas the O + CH4(vk = 1) reactions produce smaller cross sections for OH(v = 1) + CH3(v = 0) than those of O + CH4(v = 0) → OH(v = 0) + CH3(v = 0). The former finding agrees with experiment and the latter awaits for confirmation. The computed cold OH rotational distributions of O + CH4(v = 0) are in good agreement with experiment.

Communication: direct comparison between theory and experiment for correlated angular and product-state distributions of the ground-state and stretching-excited O((3)P) + CH4 reactions.

PubMed

Czakó, Gábor

2014-06-21

Motivated by a recent experiment [H. Pan and K. Liu, J. Chem. Phys. 140, 191101 (2014)], we report a quasiclassical trajectory study of the O((3)P) + CH4(vk = 0, 1) → OH + CH3 [k = 1 and 3] reactions on an ab initio potential energy surface. The computed angular distributions and cross sections correlated to the OH(v = 0, 1) + CH3(v = 0) coincident product states can be directly compared to experiment for O + CH4(v3 = 0, 1). Both theory and experiment show that the ground-state reaction is backward scattered, whereas the angular distributions shift toward sideways and forward directions upon antisymmetric stretching (v3) excitation of the reactant. Theory predicts similar behavior for the O + CH4(v1 = 1) reaction. The simulations show that stretching excitation enhances the reaction up to about 15 kcal/mol collision energy, whereas the O + CH4(vk = 1) reactions produce smaller cross sections for OH(v = 1) + CH3(v = 0) than those of O + CH4(v = 0) → OH(v = 0) + CH3(v = 0). The former finding agrees with experiment and the latter awaits for confirmation. The computed cold OH rotational distributions of O + CH4(v = 0) are in good agreement with experiment.

New synchrotron powder diffraction facility for long-duration experiments

PubMed Central

Murray, Claire A.; Potter, Jonathan; Day, Sarah J.; Baker, Annabelle R.; Thompson, Stephen P.; Kelly, Jon; Morris, Christopher G.; Tang, Chiu C.

2017-01-01

A new synchrotron X-ray powder diffraction instrument has been built and commissioned for long-duration experiments on beamline I11 at Diamond Light Source. The concept is unique, with design features to house multiple experiments running in parallel, in particular with specific stages for sample environments to study slow kinetic systems or processes. The instrument benefits from a high-brightness X-ray beam and a large area detector. Diffraction data from the commissioning work have shown that the objectives and criteria are met. Supported by two case studies, the results from months of measurements have demonstrated the viability of this large-scale instrument, which is the world’s first dedicated facility for long-term studies (weeks to years) using synchrotron radiation. PMID:28190992

Heterozygous Submicroscopic Inversions Involving Olfactory Receptor–Gene Clusters Mediate the Recurrent t(4;8)(p16;p23) Translocation

PubMed Central

Giglio, Sabrina; Calvari, Vladimiro; Gregato, Giuliana; Gimelli, Giorgio; Camanini, Silvia; Giorda, Roberto; Ragusa, Angela; Guerneri, Silvana; Selicorni, Angelo; Stumm, Marcus; Tonnies, Holger; Ventura, Mario; Zollino, Marcella; Neri, Giovanni; Barber, John; Wieczorek, Dagmar; Rocchi, Mariano; Zuffardi, Orsetta

2002-01-01

The t(4;8)(p16;p23) translocation, in either the balanced form or the unbalanced form, has been reported several times. Taking into consideration the fact that this translocation may be undetected in routine cytogenetics, we find that it may be the most frequent translocation after t(11q;22q), which is the most common reciprocal translocation in humans. Case subjects with der(4) have the Wolf-Hirschhorn syndrome, whereas case subjects with der(8) show a milder spectrum of dysmorphic features. Two pairs of the many olfactory receptor (OR)–gene clusters are located close to each other, on both 4p16 and 8p23. Previously, we demonstrated that an inversion polymorphism of the OR region at 8p23 plays a crucial role in the generation of chromosomal imbalances through unusual meiotic exchanges. These findings prompted us to investigate whether OR-related inversion polymorphisms at 4p16 and 8p23 might also be involved in the origin of the t(4;8)(p16;p23) translocation. In seven case subjects (five of whom both represented de novo cases and were of maternal origin), including individuals with unbalanced and balanced translocations, we demonstrated that the breakpoints fell within the 4p and 8p OR-gene clusters. FISH experiments with appropriate bacterial-artificial-chromosome probes detected heterozygous submicroscopic inversions of both 4p and 8p regions in all the five mothers of the de novo case subjects. Heterozygous inversions on 4p16 and 8p23 were detected in 12.5% and 26% of control subjects, respectively, whereas 2.5% of them were scored as doubly heterozygous. These novel data emphasize the importance of segmental duplications and large-scale genomic polymorphisms in the evolution and pathology of the human genome. PMID:12058347

NASA Wallops Flight Facility Air-Sea Interaction Research Facility

NASA Technical Reports Server (NTRS)

Long, Steven R.

1992-01-01

This publication serves as an introduction to the Air-Sea Interaction Research Facility at NASA/GSFC/Wallops Flight Facility. The purpose of this publication is to provide background information on the research facility itself, including capabilities, available instrumentation, the types of experiments already done, ongoing experiments, and future plans.

Novel RepA-MCM proteins encoded in plasmids pTAU4, pORA1 and pTIK4 from Sulfolobus neozealandicus

PubMed Central

Greve, Bo; Jensen, Susanne; Phan, Hoa; Brügger, Kim; Zillig, Wolfram; She, Qunxin; Garrett, Roger A.

2005-01-01

Three plasmids isolated from the crenarchaeal thermoacidophile Sulfolobus neozealandicus were characterized. Plasmids pTAU4 (7,192 bp), pORA1 (9,689 bp) and pTIK4 (13,638 bp) show unusual properties that distinguish them from previously characterized cryptic plasmids of the genus Sulfolobus. Plasmids pORA1 and pTIK4 encode RepA proteins, only the former of which carries the novel polymerase–primase domain of other known Sulfolobus plasmids. Plasmid pTAU4 encodes a mini-chromosome maintenance protein homolog and no RepA protein; the implications for DNA replication are considered. Plasmid pORA1 is the first Sulfolobus plasmid to be characterized that does not encode the otherwise highly conserved DNA-binding PlrA protein. Another encoded protein appears to be specific for the New Zealand plasmids. The three plasmids should provide useful model systems for functional studies of these important crenarchaeal proteins. PMID:15876565

A technician monitors the CHeX, a USMP-4 experiment which will be flown on STS-87, in the SSPF

NASA Technical Reports Server (NTRS)

1997-01-01

United States Microgravity Payload-4 (USMP-4) experiments are prepared to be flown on Space Shuttle mission STS-87 in the Space Station Processing Facility at Kennedy Space Center (KSC). Here, a technician is monitoring the Confined Helium Experiment, or CHeX, that will use microgravity to study one of the basic influences on the behavior and properties of materials by using liquid helium confined between silicon disks. CHeX and several other experiments are scheduled for launch aboard STS-87 on Nov. 19 from KSC.

Effect of pH and Electrolytes on Adsorption of 2,4-D onto Kaolinite

NASA Astrophysics Data System (ADS)

Sharma, A.; Kawamoto, K.; Komatsu, T.; Moldrup, P.

2006-12-01

The fate and transport of pesticides in soil can be greatly influenced by adsorption onto clay minerals such as kaolinite. The ionic pesticide 2,4-D (2,4-dichlorophenoxyacetic acid) is one of the most commonly used herbicides. The purpose of this study is to investigate the effect of electrolytes and pH on the adsorption of 2,4- D onto kaolinite. The adsorption coefficient (Kd) of 2,4-D on two types of kaolinite was measured in batch experiments using water and 4 different electrolytes (0.005M CaSO4, 0.005M CaCl2, 0.01M KCl, and 0.01M NaCl). The experiments were carried out with 0.5 g kaolinite at a solid:liquid ratio of 1:20 and at different pH (1.9-6.3). The pH of the solution was controlled by addition of 0.2N of HCl. X-ray diffraction analysis of both kaolinite with and without adsorbed 2,4-D was also done to understand the location of 2,4-D adsorption. The effects of pH and electrolytes on Kd were compared and possible adsorption mechanisms were revealed for 2,4-D adsorption onto the two different types of kaolinite. The results implied that 2,4-D adsorption was higher for an electrolyte solution with monovalent cation than with divalent cation for one type of kaolinite, while no such trend was observed for the other kaolinite. The adsorption of 2,4-D increased significantly with decreasing pH for both types of kaolinite.

Calculation of the total electron excitation cross section in the Born approximation using Slater wave functions for the Li (2s yields 2p), Li (2s yields 3p), Na (3s yields 4p), Mg (3p yields 4s), Ca (4s yields 4p) and K (4s yields 4p) excitations. M.S. Thesis

NASA Technical Reports Server (NTRS)

Simsic, P. L.

1974-01-01

Excitation of neutral atoms by inelastic scattering of incident electrons in gaseous nebulae were investigated using Slater Wave functions to describe the initial and final states of the atom. Total cross sections using the Born Approximation are calculated for: Li(2s yields 2p), Na(3s yields 4p), k(4s yields 4p). The intensity of emitted radiation from gaseous nebulae is also calculated, and Maxwell distribution is employed to average the kinetic energy of electrons.

Measurements of the strong-interaction widths of the kaonic 3He and 4He 2p levels

PubMed Central

Bazzi, M.; Beer, G.; Bombelli, L.; Bragadireanu, A.M.; Cargnelli, M.; Curceanu (Petrascu), C.; dʼUffizi, A.; Fiorini, C.; Frizzi, T.; Ghio, F.; Guaraldo, C.; Hayano, R.S.; Iliescu, M.; Ishiwatari, T.; Iwasaki, M.; Kienle, P.; Levi Sandri, P.; Longoni, A.; Marton, J.; Okada, S.; Pietreanu, D.; Ponta, T.; Rizzo, A.; Romero Vidal, A.; Sbardella, E.; Scordo, A.; Shi, H.; Sirghi, D.L.; Sirghi, F.; Tatsuno, H.; Tudorache, A.; Tudorache, V.; Vazquez Doce, O.; Wünschek, B.; Widmann, E.; Zmeskal, J.

2012-01-01

The kaonic 3He and 4He X-rays emitted in the 3d→2p transitions were measured in the SIDDHARTA experiment. The widths of the kaonic 3He and 4He 2p states were determined to be Γ2p(He3)=6±6(stat.)±7 (syst.) eV, and Γ2p(He4)=14±8 (stat.)±5 (syst.) eV, respectively. Both results are consistent with the theoretical predictions. The width of kaonic 4He is much smaller than the value of 55±34 eV determined by the experiments performed in the 70ʼs and 80ʼs, while the width of kaonic 3He was determined for the first time. PMID:22876000

48 CFR 1422.101-4 - Removal of items from contractors' facilities affected by work stoppages.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITIONS Basic Labor Policies 1422.101-4 Removal of items from contractors' facilities affected by work... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Removal of items from contractors' facilities affected by work stoppages. 1422.101-4 Section 1422.101-4 Federal Acquisition...

30 CFR 75.1712-4 - Waiver of surface facilities requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements of §§ 75.1712-1 through 75.1712-3 if he determines that the operator of the mine cannot or need... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Waiver of surface facilities requirements. 75.1712-4 Section 75.1712-4 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...

Research and test facilities for development of technologies and experiments with commercial applications

NASA Technical Reports Server (NTRS)

1989-01-01

One of NASA'S agency-wide goals is the commercial development of space. To further this goal NASA is implementing a policy whereby U.S. firms are encouraged to utilize NASA facilities to develop and test concepts having commercial potential. Goddard, in keeping with this policy, will make the facilities and capabilities described in this document available to private entities at a reduced cost and on a noninterference basis with internal NASA programs. Some of these facilities include: (1) the Vibration Test Facility; (2) the Battery Test Facility; (3) the Large Area Pulsed Solar Simulator Facility; (4) the High Voltage Testing Facility; (5) the Magnetic Field Component Test Facility; (6) the Spacecraft Magnetic Test Facility; (7) the High Capacity Centrifuge Facility; (8) the Acoustic Test Facility; (9) the Electromagnetic Interference Test Facility; (10) the Space Simulation Test Facility; (11) the Static/Dynamic Balance Facility; (12) the High Speed Centrifuge Facility; (13) the Optical Thin Film Deposition Facility; (14) the Gold Plating Facility; (15) the Paint Formulation and Application Laboratory; (16) the Propulsion Research Laboratory; (17) the Wallops Range Facility; (18) the Optical Instrument Assembly and Test Facility; (19) the Massively Parallel Processor Facility; (20) the X-Ray Diffraction and Scanning Auger Microscopy/Spectroscopy Laboratory; (21) the Parts Analysis Laboratory; (22) the Radiation Test Facility; (23) the Ainsworth Vacuum Balance Facility; (24) the Metallography Laboratory; (25) the Scanning Electron Microscope Laboratory; (26) the Organic Analysis Laboratory; (27) the Outgassing Test Facility; and (28) the Fatigue, Fracture Mechanics and Mechanical Testing Laboratory.

Theoretical level energies and transition data for 4p64d4, 4p64d34f and 4p54d5 configurations of W34+ ion

NASA Astrophysics Data System (ADS)

Karpuškienė, R.; Bogdanovich, P.; Kisielius, R.

2017-05-01

The ab initio quasirelativistic approach developed specifically for the calculation of spectral parameters of highly charged ions was used to derive transition data for the tungsten ion W34+. The configuration interaction method was applied to include electron correlation effects. The relativistic effects were taken into account in the Breit-Pauli approximation. The level energies, radiative lifetimes τ, Landé g-factors are determined for the ground configuration 4p64d4 and two excited configurations 4p64d34f and 4p54d5. The radiative transition wavelengths λ and emission transition probabilities A for the electric dipole, electric quadrupole, electric octupole, magnetic dipole, and magnetic quadrupole transitions among the levels of these configurations are produced.

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2011 CFR

2011-01-01

....8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G Street, NW., Washington, DC. The facility shall be open to...

4 CFR 81.8 - Public reading facility.

Code of Federal Regulations, 2010 CFR

2010-01-01

....8 Public reading facility. GAO maintains a public reading facility in the Law Library at the Government Accountability Office Building, 441 G Street, NW., Washington, DC. The facility shall be open to...

Status of power generation experiments in the NASA Lewis closed cycle MHD facility

NASA Technical Reports Server (NTRS)

Sovie, R. J.; Nichols, L. D.

1971-01-01

The design and operation of the closed cycle MHD facility is discussed and results obtained in recent experiments are presented. The main components of the facility are a compressor, recuperative heat exchanger, heater, nozzle, MHD channel with 28 pairs of thoriated tungsten electrodes, cesium condenser, and an argon cooler. The facility has been operated at temperatures up to 2100 K with a cesium-seeded argon working fluid. At low magnetic field strengths, the open circuit voltage, Hall voltage and short circuit current obtained are 90, 69, and 47 percent of the theoretical equilibrium values, respectively. Comparison of this data with a wall and boundary layer leakage theory indicates that the generator has shorting paths in the Hall direction.

Strengthening health facilities for maternal and newborn care: experiences from rural eastern Uganda

PubMed Central

Namazzi, Gertrude; Waiswa, Peter; Nakakeeto, Margaret; Nakibuuka, Victoria K.; Namutamba, Sarah; Najjemba, Maria; Namusaabi, Ruth; Tagoola, Abner; Nakate, Grace; Ajeani, Judith; Peterson, Stefan; Byaruhanga, Romano N.

2015-01-01

Background In Uganda maternal and neonatal mortality remains high due to a number of factors, including poor quality of care at health facilities. Objective This paper describes the experience of building capacity for maternal and newborn care at a district hospital and lower-level health facilities in eastern Uganda within the existing system parameters and a robust community outreach programme. Design This health system strengthening study, part of the Uganda Newborn Study (UNEST), aimed to increase frontline health worker capacity through district-led training, support supervision, and mentoring at one district hospital and 19 lower-level facilities. A once-off supply of essential medicines and equipment was provided to address immediate critical gaps. Health workers were empowered to requisition subsequent supplies through use of district resources. Minimal infrastructure adjustments were provided. Quantitative data collection was done within routine process monitoring and qualitative data were collected during support supervision visits. We use the World Health Organization Health System Building Blocks to describe the process of district-led health facility strengthening. Results Seventy two per cent of eligible health workers were trained. The mean post-training knowledge score was 68% compared to 32% in the pre-training test, and 80% 1 year later. Health worker skills and competencies in care of high-risk babies improved following support supervision and mentoring. Health facility deliveries increased from 3,151 to 4,115 (a 30% increase) in 2 years. Of 547 preterm babies admitted to the newly introduced kangaroo mother care (KMC) unit, 85% were discharged alive to continue KMC at home. There was a non-significant declining trend for in-hospital neonatal deaths across the 2-year study period. While equipment levels remained high after initial improvement efforts, maintaining supply of even the most basic medications was a challenge, with less than 40% of

Correlations among self-esteem, aggression, adverse childhood experiences and depression in inmates of a female juvenile correctional facility in Japan.

PubMed

Matsuura, Naomi; Hashimoto, Toshiaki; Toichi, Motomi

2009-08-01

The purpose of this study was to examine the following hypothesis: (i) Self-esteem and aggressiveness, adverse childhood experiences (ACE), and a depressive tendency interact with each other. (ii) The subjects show a strong depressive tendency, and each of the other factors exerts a main effect on, and interacts with, the depressive tendency. The subjects were 91 juveniles (all female) admitted to a female juvenile correctional facility between November 2005 and December 2006. They were aged 15-19 years, with a mean age of 17.0 (SD = 1.18) years. Self-esteem scale, aggression scale, ACE questionnaire, and depression scale were conducted. Significant main effects (R(2) = 0.50, P < 0.001) on the depression score were observed in self-esteem (beta = -0.41, P < 0.001) and aggression (beta = 0.21, P < 0.05). Self-esteem, aggression, ACE, and depression were found to be interrelated. Low self-esteem was also shown to exert marked effects on various factors. About half of the inmates of the facility were depressed, and the main effects of self-esteem, aggression, and the ACE score were shown to influence the depression score.

4. Anode Building. View is to the east. This facility, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Anode Building. View is to the east. This facility, which was used for the cleaning and manufacture of anodes, was documented prior to demolition in 1993. - Sullivan Electrolytic Zinc Plant, Government Gulch, Kellogg, Shoshone County, ID

Experiment Definition Using the Space Laboratory, Long Duration Exposure Facility, and Space Transportation System Shuttle

NASA Technical Reports Server (NTRS)

Sheppard, Albert P.; Wood, Joan M.

1976-01-01

Candidate experiments designed for the space shuttle transportation system and the long duration exposure facility are summarized. The data format covers: experiment title, Experimenter, technical abstract, benefits/justification, technical discussion of experiment approach and objectives, related work and experience, experiment facts space properties used, environmental constraints, shielding requirements, if any, physical description, and sketch of major elements. Information was also included on experiment hardware, research required to develop experiment, special requirements, cost estimate, safety considerations, and interactions with spacecraft and other experiments.

Pilot production of 4 sq cm ITO/InP photovoltaic solar cells

NASA Technical Reports Server (NTRS)

Gessert, T. A.; Li, X.; Coutts, T. J.; Tzafaras, N.

1991-01-01

Experimental results of a pilot production of 32 4-sq cm indium tin oxide (ITO)InP space solar cells are presented. The discussion includes analysis of the device performance of the best cells produced as well as the performance range of all production cells. The experience gained from the production is discussed, indicating other issues that may be encountered when large-scale productions are initiated. Available data on a 4-sq cm ITO/InP cell that was flown on the UoSAT-5 satellite is reported.

Realizing p-Type MoS2 with Enhanced Thermoelectric Performance by Embedding VMo2S4 Nanoinclusions.

PubMed

Kong, Shuang; Wu, Tianmin; Zhuang, Wei; Jiang, Peng; Bao, Xinhe

2018-01-18

Two-dimensional transition-metal dichalcogenide semiconductors (TMDCs) such as MoS 2 are attracting increasing interest as thermoelectric materials owing to their abundance, nontoxicity, and promising performance. Recently, we have successfully developed n-type MoS 2 thermoelectric material via oxygen doping. Nevertheless, an efficient thermoelectric module requires both n-type and p-type materials with similar compatibility factors. Here, we present a facile approach to obtain a p-type MoS 2 thermoelectric material with a maximum figure of merit of 0.18 through the introduction of VMo 2 S 4 as a second phase by vanadium doping. VMo 2 S 4 nanoinclusions, confirmed by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) measurements, not only improve the electrical conductivity by simultaneously increasing the carrier concentration and the mobility but also result in the reduction of lattice thermal conductivity by enhancing the interface phonon scattering. Our studies not only shed new light toward improving thermoelectric performance of TMDCs by a facile elemental doping strategy but also pave the way toward thermoelectric devices based on TMDCs.

P(4-vinyl pyridine) hydrogel use for the removal of UO(2)(2+) and Th(4+) from aqueous environments.

PubMed

Ozay, Ozgur; Ekici, Sema; Aktas, Nahit; Sahiner, Nurettin

2011-12-01

4-vinyl pyridine (4-VP) based hydrogels with 2-hydroxyethylmetacrylate (HEMA) and magnetic composites were prepared and tested for use in the removal of UO(2)(2+) and Th(4+) ions from aqueous environments. It was found that the absorption of these metal ions from aqueous environments decreased with an increase in the amount of HEMA contained within p(4-VP-co-HEMA) hydrogels between 0.498 mmol for pure p(4-VP) and 0.027 mmol for pure p(HEMA). The characterization of the hydrogels was determined by swelling experiments, FT-IR and thermal analysis. The effects of initial metal ion concentration, hydrogel amount and the temperature of the medium on absorption of the ions were investigated. Langmuir and Freundlich isotherms were constructed for the absorption of UO(2)(2+) and Th(4+). Both isotherms demonstrated that these metal ions complied with monolayer absorption kinetics. Copyright © 2011 Elsevier Ltd. All rights reserved.

Results from colliding magnetized plasma jet experiments executed at the Trident laser facility

NASA Astrophysics Data System (ADS)

Manuel, M. J.-E.; Rasmus, A. M.; Kurnaz, C. C.; Klein, S. R.; Davis, J. S.; Drake, R. P.; Montgomery, D. S.; Hsu, S. C.; Adams, C. S.; Pollock, B. B.

2015-11-01

The interaction of high-velocity plasma flows in a background magnetic field has applications in pulsed-power and fusion schemes, as well as astrophysical environments, such as accretion systems and stellar mass ejections into the magnetosphere. Experiments recently executed at the Trident Laser Facility at the Los Alamos National Laboratory investigated the effects of an expanding aluminum plasma flow into a uniform 4.5-Tesla magnetic field created using a solenoid designed and manufactured at the University of Michigan. Opposing-target experiments demonstrate interesting collisional behavior between the two magnetized flows. Preliminary interferometry and Faraday rotation measurements will be presented and discussed. This work is funded by the U.S Department of Energy, through the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, grant number DE-NA0001840. Support for this work was provided by NASA through Einstein Postdoctoral Fellowship grant number PF3-140111 awarded by the Chandra X-ray Center, which is operated by the Astrophysical Observatory for NASA under contract NAS8-03060.

WRF4SG: A Scientific Gateway for climate experiment workflows

NASA Astrophysics Data System (ADS)

Blanco, Carlos; Cofino, Antonio S.; Fernandez-Quiruelas, Valvanuz

2013-04-01

, the user has to select them browsing through LFC Portlet. * Design Experiment workflow: In order to configure the experiment, the user will define the type of experiment (i.e. re-forecast), and its attributes to simulate. In this case the main attributes are: the field of interest (wind, precipitation, ...), the start and end date simulation and the requirements of the experiment. * Monitor workflow: In order to monitor the experiment the user will receive notification messages based on events and also the gateway will display the progress of the experiment. * Data storage: Like Data assimilation case, the user is able to browse and view the output data simulations using LFC Portlet. The objectives of WRF4SG can be described by considering two goals. The first goal is to show how WRF4SG facilitates to execute, monitor and manage climate workflows based on the WRF4G framework. And the second goal of WRF4SG is to help WRF users to execute their experiment workflows concurrently using heterogeneous computing resources such as HPC and Grid. [1] Kacsuk, P.: P-GRADE portal family for grid infrastructures. Concurrency and Computation: Practice and Experience. 23, 235-245 (2011). [2] http://www.meteo.unican.es/software/wrf4g

The inescapable question of fairness in Pay-for-performance bonus distribution: a qualitative study of health workers' experiences in Tanzania.

PubMed

Chimhutu, Victor; Songstad, Nils Gunnar; Tjomsland, Marit; Mrisho, Mwifadhi; Moland, Karen Marie

2016-11-25

During the last decade there has been a growing concern about the lack of results in the health sectors of many low income countries. Progress has been particularly slow in maternal- and child health. Prompted by the need to accelerate progress towards these health outcomes, pay-for- performance (P4P) schemes have been initiated in a number of countries. This paper explores the perceptions and experiences of health workers with P4P bonus distribution in the health system context of rural Tanzania. This qualitative study was based on the P4P pilot in Pwani Region of Tanzania. The study took place in 11 health care facilities in Rufiji District. The study informants and participants were different cadres of health workers assigned to different outpatient and inpatient departments at the health facilities, and local administrators of the P4P bonus distribution. Thirty two in-depth interviews (IDIs) with administrators and health care workers, and six focus group discussions (FGDs with Reproductive and Child Health (RCH) staff, non-RCH staff and non-medical staff were conducted. Collected data was analyzed through qualitative content analysis. The study found that the bonus distribution modality employed in the P4P programme was experienced as fundamentally unjust. The bonuses were calculated according to the centrality of the health worker position in meeting targeted indicators, drawn from the reproductive and child health (RCH) section. Both RCH staff and non-RCH perceived the P4P bonus as unfair. Non-RCH objected to getting less bonus than RCH staff, and RCH staff running the targeted RCH services, objected to not getting more P4P bonus. Non-RCH staff and health administrators suggested a flat-rate across board as the fairest way of distributing P4P bonuses. The perceived unfairness affected work motivation, undermined teamwork across departments and created tensions in the social relations at health facilities. Our results suggest that the experience of unfairness

Optical velocimetry at the Los Alamos Proton Radiography Facility

NASA Astrophysics Data System (ADS)

Tupa, Dale; Tainter, Amy; Neukirch, Levi; Hollander, Brian; Buttler, William; Holtkamp, David; The Los Alamos Proton Radiography Team Team

2016-05-01

The Los Alamos Proton Radiography Facility (pRad) employs a high-energy proton beam to image the properties and behavior of materials driven by high explosives. We will discuss features of pRad and describe some recent experiments, highlighting optical diagnostics for surface velocity measurements.

Proton therapy detector studies under the experience gained at the CATANA facility

NASA Astrophysics Data System (ADS)

Cuttone, G.; Cirrone, G. A. P.; Di Rosa, F.; Lojacono, P. A.; Lo Nigro, S.; Marino, C.; Mongelli, V.; Patti, I. V.; Pittera, S.; Raffaele, L.; Russo, G.; Sabini, M. G.; Salamone, V.; Valastro, L. M.

2007-10-01

Proton therapy represents the most promising radiotherapy technique for external tumor treatments. At Laboratori Nazionali del Sud of the Istituto Nazionale di Fisica Nucleare (INFN-LNS), Catania (I), a proton therapy facility is active since March 2002 and 140 patients, mainly affected by choroidal and iris melanoma, have been successfully treated. Proton beams are characterized by higher dose gradients and linear energy transfer with respect to the conventional photon and electron beams, commonly used in medical centers for radiotherapy.In this paper, we report the experience gained in the characterization of different dosimetric systems, studied and/or developed during the last ten years in our proton therapy facility.

LET spectra measurements of charged particles in the P0006 experiment on LDEF

NASA Technical Reports Server (NTRS)

Benton, E. V.; Csige, I.; Oda, K.; Henke, R. P.; Frank, A. L.; Benton, E. R.; Frigo, L. A.; Parnell, T. A.; Watts, J. W., Jr.; Derrickson, J. H.

1993-01-01

Measurements are under way of the charged particle radiation environment of the Long Duration Exposure Facility (LDEF) satellite using stacks of plastic nuclear track detectors (PNTD's) placed in different locations of the satellite. In the initial work the charge, energy, and linear energy transfer (LET) spectra of charged particles were measured with CR-39 double layer PNTD's located on the west side of the satellite (Experiment P0006). Primary and secondary stopping heavy ions were measured separately from the more energetic particles. Both trapped and galactic cosmic ray (GCR) particles are included, with the latter component being dominated by relativistic iron particles. The results from the P0006 experiment will be compared with similar measurements in other locations on LDEF with different orientation and shielding conditions. The remarkably detailed investigation of the charged particle radiation environment of the LDEF satellite will lead to a better understanding of the radiation environment of the Space Station Freedom. It will enable more accurate prediction of single event upsets (SEU's) in microelectronics and, especially, more accurate assessment of the risk - contributed by different components of the radiation field (GCR's, trapped protons, secondaries and heavy recoils, etc.) - to the health and safety of crew members.

Tungsten phosphanylarylthiolato complexes [W{PhP(2-SC6H4)2-kappa3S,S',P} 2] and [W{P(2-SC6H4)3-kappa4S,S',S",P}2]: synthesis, structures and redox chemistry.

PubMed

Hildebrand, Alexandra; Lönnecke, Peter; Silaghi-Dumitrescu, Luminita; Hey-Hawkins, Evamarie

2008-09-14

PhP(2-SHC6H4)2 (PS2H2) reacts with WCl6 with reduction of tungsten to give the air-sensitive tungsten(IV) complex [W{PhP(2-SC6H4)2-kappa(3)S,S',P}2] (1). 1 is oxidised in air to [WO{PhPO(2-SC6H4)2-kappa(3)S,S',O}{PhP(2-SC6H4)2-kappa(3)S,S',P}] (2). The attempted synthesis of 2 by reaction of 1 with iodosobenzene as oxidising agent was unsuccessful. [W{P(2-SC6H4)3-kappa(4)S,S',S",P}2] (3) was formed in the reaction of P(2-SHC6H4)3 (PS3H3) with WCl6. The W(VI) complex 3 contains two PS3(3-) ligands, each coordinated in a tetradentate fashion resulting in a tungsten coordination number of eight. The reaction of 3 with AgBF4 yields the dinuclear tungsten complex [W2{P(2-SC6H4)3-kappa(4)S,S',S",P}3]BF4 (4). Complexes 1-4 were characterised by spectral methods and X-ray structure determination.

Na7Cr4(P2O7)4PO4

PubMed Central

Bourguiba Fakhar, Noura; Zid, Mohamed Faouzi; Driss, Ahmed

2013-01-01

The title compound, hepta­sodium tetra­chromium(III) tetra­kis­(diphosphate) orthophosphate, was synthesized by solid-state reaction. Its structure is isotypic with that of Na7 M 4(P2O7)4PO4 (M = In, Al) compounds and is made up from a three-dimensional [(CrP2O7)4PO4]7− framework with channels running along [001]. The three Na+ cations are located in the voids of the framework. One of the cations is situated on a general position, one is equally disordered around a twofold rotation axis and one is on a fourfold rotoinversion axis. The isolated PO4 tetra­hedron of the anionic framework is also situated on the -4 axis. Structural relationships between the title compound and different diphosphates containing MP2O11 units (M = Mo, V) are discussed. PMID:23723751

[Pay for performance in dental care: A systematic narrative review of quality P4P models in dental care].

PubMed

Chenot, Regine

2017-11-01

Pay for performance (P4P) links reimbursement to the achievement of quality objectives. Experiences with P4P instruments and studies on their effects are available for the inpatient sector. A systematic narrative review brings together findings concerning the use and the effects of P4P, especially in dental care. A systematic literature search in PubMed and the Cochrane Library for reimbursement models using quality indicators provided 77 publications. Inclusion criteria were: year of publication not older than 2007, dental sector, models of quality-oriented remuneration, quality of care, quality indicators. 27 publications met the inclusion criteria and were evaluated with regard to the instruments and effects of P4P. The database search was supplemented by a free search on the Internet as well as a search in indicator databases and portals. The results of the included studies were extracted and summarized narratively. 27 studies were included in the review. Performance-oriented remuneration is an instrument of quality competition. In principle, P4P is embedded in an existing remuneration system, i.e., it does not occur in isolation. In the United States, England and Scandinavia, models are currently being tested for quality-oriented remuneration in dental care, based on quality indicators. The studies identified by the literature search are very heterogeneous and do not yield comparable endpoints. Difficulties are seen in the reproducibility of the quality of dental care with regard to certain characteristics which still have to be defined as quality-promoting properties. Risk selection cannot be ruled out, which may have an impact on structural quality (access to care, coordination). There were no long-term effects of P4P on the quality of care. In the short and medium term, adverse effects on the participants' motivation as well as shifting effects towards the private sector are described. A prerequisite for the functioning of P4P is the definition of clear

High-density carbon capsule experiments on the national ignition facility

DOE PAGES

Ross, J. S.; Ho, D.; Milovich, J.; ...

2015-02-25

Indirect-drive implosions with a high-density carbon (HDC) capsule were conducted on the National Ignition Facility (NIF) to test HDC properties as an ablator material for inertial confinement fusion. In this study, a series of five experiments were completed with 76-μm-thick HDC capsules using a four-shock laser pulse optimized for HDC. The pulse delivered a total energy of 1.3 MJ with a peak power of 360 TW. The experiment demonstrated good laser to target coupling (~90 %) and excellent nuclear performance. Lastly, a deuterium and tritium gas-filled HDC capsule implosion produced a neutron yield of 1.6×10 15 ± 3×10 13, amore » yield over simulated in one dimension of 70%.« less

Experiments on the transportation of a magnetized plasma stream in the GOL-3 facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Postupaev, V. V., E-mail: V.V.Postupaev@inp.nsk.su; Batkin, V. I.; Burdakov, A. V.

2016-04-15

The program of the deep upgrade of the GOL-3 multiple-mirror trap is presented. The upgrade is aimed at creating a new GOL-NB open trap located at the GOL-3 site and intended to directly demonstrate the efficiency of using multiple-mirror magnetic cells to improve longitudinal plasma confinement in a gasdynamic open trap. The GOL-NB device will consist of a new central trap, adjoint cells with a multiple-mirror magnetic field, and end tanks (magnetic flux expanders). Plasma in the central trap will be heated by neutral beam injection with a power of up to 1.5 MW and duration of 1 ms. Atmore » present, physical experiments directed at developing plasma technologies that are novel for this facility are being carried out using the 6-m-long autonomous part of the GOL-3 solenoid. The aim of this work was to develop a method for filling the central trap with a low-temperature start plasma. Transportation of a plasma stream from an arc source over a distance of 3 m in a uniform magnetic field with an induction of 0.5–4.5 T is demonstrated. In these experiments, the axial plasma density was (1–4) × 10{sup 20} m{sup –3} and the mirror ratio varied from 5 to 60. In general, the experiments confirmed the correctness of the adopted decisions for the start plasma source of the GOL-NB device.« less

Conceptual design of initial opacity experiments on the national ignition facility

NASA Astrophysics Data System (ADS)

Heeter, R. F.; Bailey, J. E.; Craxton, R. S.; Devolder, B. G.; Dodd, E. S.; Garcia, E. M.; Huffman, E. J.; Iglesias, C. A.; King, J. A.; Kline, J. L.; Liedahl, D. A.; McKenty, P. W.; Opachich, Y. P.; Rochau, G. A.; Ross, P. W.; Schneider, M. B.; Sherrill, M. E.; Wilson, B. G.; Zhang, R.; Perry, T. S.

2017-02-01

Accurate models of X-ray absorption and re-emission in partly stripped ions are necessary to calculate the structure of stars, the performance of hohlraums for inertial confinement fusion and many other systems in high-energy-density plasma physics. Despite theoretical progress, a persistent discrepancy exists with recent experiments at the Sandia Z facility studying iron in conditions characteristic of the solar radiative-convective transition region. The increased iron opacity measured at Z could help resolve a longstanding issue with the standard solar model, but requires a radical departure for opacity theory. To replicate the Z measurements, an opacity experiment has been designed for the National Facility (NIF). The design uses established techniques scaled to NIF. A laser-heated hohlraum will produce X-ray-heated uniform iron plasmas in local thermodynamic equilibrium (LTE) at temperatures eV and electron densities 21~\\text{cm}-3$ . The iron will be probed using continuum X-rays emitted in a ps, diameter source from a 2 mm diameter polystyrene (CH) capsule implosion. In this design, of the NIF beams deliver 500 kJ to the mm diameter hohlraum, and the remaining directly drive the CH capsule with 200 kJ. Calculations indicate this capsule backlighter should outshine the iron sample, delivering a point-projection transmission opacity measurement to a time-integrated X-ray spectrometer viewing down the hohlraum axis. Preliminary experiments to develop the backlighter and hohlraum are underway, informing simulated measurements to guide the final design.

Global meteorological data facility for real-time field experiments support and guidance

NASA Technical Reports Server (NTRS)

Shipham, Mark C.; Shipley, Scott T.; Trepte, Charles R.

1988-01-01

A Global Meteorological Data Facility (GMDF) has been constructed to provide economical real-time meteorological support to atmospheric field experiments. After collection and analysis of meteorological data sets at a central station, tailored meteorological products are transmitted to experiment field sites using conventional ground link or satellite communication techniques. The GMDF supported the Global Tropospheric Experiment Amazon Boundary Layer Experiment (GTE-ABLE II) based in Manaus, Brazil, during July and August 1985; an arctic airborne lidar survey mission for the Polar Stratospheric Clouds (PSC) experiment during January 1986; and the Genesis of Atlantic Lows Experiment (GALE) during January, February and March 1986. GMDF structure is similar to the UNIDATA concept, including meteorological data from the Zephyr Weather Transmission Service, a mode AAA GOES downlink, and dedicated processors for image manipulation, transmission and display. The GMDF improved field experiment operations in general, with the greatest benefits arising from the ability to communicate with field personnel in real time.

HITRAP: A Facility for Experiments with Trapped Highly Charged Ions

NASA Astrophysics Data System (ADS)

Quint, W.; Dilling, J.; Djekic, S.; Häffner, H.; Hermanspahn, N.; Kluge, H.-J.; Marx, G.; Moore, R.; Rodriguez, D.; Schönfelder, J.; Sikler, G.; Valenzuela, T.; Verdú, J.; Weber, C.; Werth, G.

2001-01-01

HITRAP is a planned ion trap facility for capturing and cooling of highly charged ions produced at GSI in the heavy-ion complex of the UNILAC-SIS accelerators and the ESR storage ring. In this facility heavy highly charged ions up to uranium will be available as bare nuclei, hydrogen-like ions or few-electron systems at low temperatures. The trap for receiving and studying these ions is designed for operation at extremely high vacuum by cooling to cryogenic temperatures. The stored highly charged ions can be investigated in the trap itself or can be extracted from the trap at energies up to about 10 keV/q. The proposed physics experiments are collision studies with highly charged ions at well-defined low energies (eV/u), high-accuracy measurements to determine the g-factor of the electron bound in a hydrogen-like heavy ion and the atomic binding energies of few-electron systems, laser spectroscopy of HFS transitions and X-ray spectroscopy.

Pressure-induced transformations in glassy water: A computer simulation study using the TIP4P/2005 model

NASA Astrophysics Data System (ADS)

Wong, Jessina; Jahn, David A.; Giovambattista, Nicolas

2015-08-01

We study the pressure-induced transformations between low-density amorphous (LDA) and high-density amorphous (HDA) ice by performing out-of-equilibrium molecular dynamics (MD) simulations. We employ the TIP4P/2005 water model and show that this model reproduces qualitatively the LDA-HDA transformations observed experimentally. Specifically, the TIP4P/2005 model reproduces remarkably well the (i) structure (OO, OH, and HH radial distribution functions) and (ii) densities of LDA and HDA at P = 0.1 MPa and T = 80 K, as well as (iii) the qualitative behavior of ρ(P) during compression-induced LDA-to-HDA and decompression-induced HDA-to-LDA transformations. At the rates explored, the HDA-to-LDA transformation is less pronounced than in experiments. By studying the LDA-HDA transformations for a broad range of compression/decompression temperatures, we construct a "P-T phase diagram" for glassy water that is consistent with experiments and remarkably similar to that reported previously for ST2 water. This phase diagram is not inconsistent with the possibility of TIP4P/2005 water exhibiting a liquid-liquid phase transition at low temperatures. A comparison with previous MD simulation studies of SPC/E and ST2 water as well as experiments indicates that, overall, the TIP4P/2005 model performs better than the SPC/E and ST2 models. The effects of cooling and compression rates as well as aging on our MD simulations results are also discussed. The MD results are qualitatively robust under variations of cooling/compression rates (accessible in simulations) and are not affected by aging the hyperquenched glass for at least 1 μs. A byproduct of this work is the calculation of TIP4P/2005 water's diffusion coefficient D(T) at P = 0.1 MPa. It is found that, for T ≥ 210 K, D(T) ≈ (T - TMCT)-γ as predicted by mode coupling theory and in agreement with experiments. For TIP4P/2005 water, TMCT = 209 K and γ = 2.14, very close to the corresponding experimental values TMCT = 221 K

Pressure-induced transformations in glassy water: A computer simulation study using the TIP4P/2005 model.

PubMed

Wong, Jessina; Jahn, David A; Giovambattista, Nicolas

2015-08-21

We study the pressure-induced transformations between low-density amorphous (LDA) and high-density amorphous (HDA) ice by performing out-of-equilibrium molecular dynamics (MD) simulations. We employ the TIP4P/2005 water model and show that this model reproduces qualitatively the LDA-HDA transformations observed experimentally. Specifically, the TIP4P/2005 model reproduces remarkably well the (i) structure (OO, OH, and HH radial distribution functions) and (ii) densities of LDA and HDA at P = 0.1 MPa and T = 80 K, as well as (iii) the qualitative behavior of ρ(P) during compression-induced LDA-to-HDA and decompression-induced HDA-to-LDA transformations. At the rates explored, the HDA-to-LDA transformation is less pronounced than in experiments. By studying the LDA-HDA transformations for a broad range of compression/decompression temperatures, we construct a "P-T phase diagram" for glassy water that is consistent with experiments and remarkably similar to that reported previously for ST2 water. This phase diagram is not inconsistent with the possibility of TIP4P/2005 water exhibiting a liquid-liquid phase transition at low temperatures. A comparison with previous MD simulation studies of SPC/E and ST2 water as well as experiments indicates that, overall, the TIP4P/2005 model performs better than the SPC/E and ST2 models. The effects of cooling and compression rates as well as aging on our MD simulations results are also discussed. The MD results are qualitatively robust under variations of cooling/compression rates (accessible in simulations) and are not affected by aging the hyperquenched glass for at least 1 μs. A byproduct of this work is the calculation of TIP4P/2005 water's diffusion coefficient D(T) at P = 0.1 MPa. It is found that, for T ≥ 210 K, D(T) ≈ (T - T(MCT))(-γ) as predicted by mode coupling theory and in agreement with experiments. For TIP4P/2005 water, T(MCT) = 209 K and γ = 2.14, very close to the corresponding experimental values T

Payment methods for outpatient care facilities.

PubMed

Yuan, Beibei; He, Li; Meng, Qingyue; Jia, Liying

2017-03-03

-after studies, interrupted time series, and repeated measures studies that compared different payment methods for outpatient health facilities. We defined outpatient care facilities in this review as facilities that provide health services to individuals who do not require hospitalisation or institutionalisation. We only included methods used to transfer funds from the purchaser of healthcare services to health facilities (including groups of individual professionals). These include global budgets, line-item budgets, capitation, fee-for-service (fixed and unconstrained), pay for performance, and mixed payment. The primary outcomes were service provision outcomes, patient outcomes, healthcare provider outcomes, costs for providers, and any adverse effects. At least two review authors independently extracted data and assessed the risk of bias. We conducted a structured synthesis. We first categorised the comparisons and outcomes and then described the effects of different types of payment methods on different categories of outcomes. We used a fixed-effect model for meta-analysis within a study if a study included more than one indicator in the same category of outcomes. We used a random-effects model for meta-analysis across studies. If the data for meta-analysis were not available in some studies, we calculated the median and interquartile range. We reported the risk ratio (RR) for dichotomous outcomes and the relative change for continuous outcomes. We included 21 studies from Afghanistan, Burundi, China, Democratic Republic of Congo, Rwanda, Tanzania, the United Kingdom, and the United States of health facilities providing primary health care and mental health care. There were three kinds of payment comparisons. 1) Pay for performance (P4P) combined with some existing payment method (capitation or different kinds of input-based payment) compared to the existing payment methodWe included 18 studies in this comparison, however we did not include five studies in the effects

College and University Facilities Survey. Part 4: College and University Enrollment and Facilities Survey 1961-65.

ERIC Educational Resources Information Center

Robbins, Leslie F.; Bokelman, W. Robert

As Part 4 of a series of five studies, data is provided by colleges and universities on what capital facilities were planned, per square foot costs, and how they were financed during 1960-61, plus how they proposed to do so up to 1965-66. Comprehensive data is presented on existing, potential, and projected enrollments, plans for constructing…

Quantifying pCO2 in biological ocean acidification experiments: A comparison of four methods.

PubMed

Watson, Sue-Ann; Fabricius, Katharina E; Munday, Philip L

2017-01-01

Quantifying the amount of carbon dioxide (CO2) in seawater is an essential component of ocean acidification research; however, equipment for measuring CO2 directly can be costly and involve complex, bulky apparatus. Consequently, other parameters of the carbonate system, such as pH and total alkalinity (AT), are often measured and used to calculate the partial pressure of CO2 (pCO2) in seawater, especially in biological CO2-manipulation studies, including large ecological experiments and those conducted at field sites. Here we compare four methods of pCO2 determination that have been used in biological ocean acidification experiments: 1) Versatile INstrument for the Determination of Total inorganic carbon and titration Alkalinity (VINDTA) measurement of dissolved inorganic carbon (CT) and AT, 2) spectrophotometric measurement of pHT and AT, 3) electrode measurement of pHNBS and AT, and 4) the direct measurement of CO2 using a portable CO2 equilibrator with a non-dispersive infrared (NDIR) gas analyser. In this study, we found these four methods can produce very similar pCO2 estimates, and the three methods often suited to field-based application (spectrophotometric pHT, electrode pHNBS and CO2 equilibrator) produced estimated measurement uncertainties of 3.5-4.6% for pCO2. Importantly, we are not advocating the replacement of established methods to measure seawater carbonate chemistry, particularly for high-accuracy quantification of carbonate parameters in seawater such as open ocean chemistry, for real-time measures of ocean change, nor for the measurement of small changes in seawater pCO2. However, for biological CO2-manipulation experiments measuring differences of over 100 μatm pCO2 among treatments, we find the four methods described here can produce similar results with careful use.

Quantifying pCO2 in biological ocean acidification experiments: A comparison of four methods

PubMed Central

Fabricius, Katharina E.; Munday, Philip L.

2017-01-01

Quantifying the amount of carbon dioxide (CO2) in seawater is an essential component of ocean acidification research; however, equipment for measuring CO2 directly can be costly and involve complex, bulky apparatus. Consequently, other parameters of the carbonate system, such as pH and total alkalinity (AT), are often measured and used to calculate the partial pressure of CO2 (pCO2) in seawater, especially in biological CO2-manipulation studies, including large ecological experiments and those conducted at field sites. Here we compare four methods of pCO2 determination that have been used in biological ocean acidification experiments: 1) Versatile INstrument for the Determination of Total inorganic carbon and titration Alkalinity (VINDTA) measurement of dissolved inorganic carbon (CT) and AT, 2) spectrophotometric measurement of pHT and AT, 3) electrode measurement of pHNBS and AT, and 4) the direct measurement of CO2 using a portable CO2 equilibrator with a non-dispersive infrared (NDIR) gas analyser. In this study, we found these four methods can produce very similar pCO2 estimates, and the three methods often suited to field-based application (spectrophotometric pHT, electrode pHNBS and CO2 equilibrator) produced estimated measurement uncertainties of 3.5–4.6% for pCO2. Importantly, we are not advocating the replacement of established methods to measure seawater carbonate chemistry, particularly for high-accuracy quantification of carbonate parameters in seawater such as open ocean chemistry, for real-time measures of ocean change, nor for the measurement of small changes in seawater pCO2. However, for biological CO2-manipulation experiments measuring differences of over 100 μatm pCO2 among treatments, we find the four methods described here can produce similar results with careful use. PMID:28957378

Solid energy calibration standards for P K-edge XANES: electronic structure analysis of PPh4Br.

PubMed

Blake, Anastasia V; Wei, Haochuan; Donahue, Courtney M; Lee, Kyounghoon; Keith, Jason M; Daly, Scott R

2018-03-01

P K-edge X-ray absorption near-edge structure (XANES) spectroscopy is a powerful method for analyzing the electronic structure of organic and inorganic phosphorus compounds. Like all XANES experiments, P K-edge XANES requires well defined and readily accessible calibration standards for energy referencing so that spectra collected at different beamlines or under different conditions can be compared. This is especially true for ligand K-edge X-ray absorption spectroscopy, which has well established energy calibration standards for Cl (Cs 2 CuCl 4 ) and S (Na 2 S 2 O 3 ·5H 2 O), but not neighboring P. This paper presents a review of common P K-edge XANES energy calibration standards and analysis of PPh 4 Br as a potential alternative. The P K-edge XANES region of commercially available PPh 4 Br revealed a single, highly resolved pre-edge feature with a maximum at 2146.96 eV. PPh 4 Br also showed no evidence of photodecomposition when repeatedly scanned over the course of several days. In contrast, we found that PPh 3 rapidly decomposes under identical conditions. Density functional theory calculations performed on PPh 3 and PPh 4 + revealed large differences in the molecular orbital energies that were ascribed to differences in the phosphorus oxidation state (III versus V) and molecular charge (neutral versus +1). Time-dependent density functional theory calculations corroborated the experimental data and allowed the spectral features to be assigned. The first pre-edge feature in the P K-edge XANES spectrum of PPh 4 Br was assigned to P 1s → P-C π* transitions, whereas those at higher energy were P 1s → P-C σ*. Overall, the analysis suggests that PPh 4 Br is an excellent alternative to other solid energy calibration standards commonly used in P K-edge XANES experiments.

An inversion inv(4)(p12-p15.3) in autistic siblings implicates the 4p GABA receptor gene cluster.

PubMed

Vincent, J B; Horike, S I; Choufani, S; Paterson, A D; Roberts, W; Szatmari, P; Weksberg, R; Fernandez, B; Scherer, S W

2006-05-01

We describe the case of two brothers diagnosed with autism who both carry a paracentic inversion of the short arm of chromosome 4 (46,XY, inv(4)(p12-p15.3)). We have determined that this inversion is inherited from an apparently unaffected mother and unaffected maternal grandfather. Methods/ Using fluorescence in situ hybridisation analysis and Southern blot hybridisation we identified the breakpoints. The proximal breakpoint (4p12) maps to a region containing a cluster of gamma-aminobutyric acid A (GABA(A)) receptor genes, and directly interrupts the GABRG1 gene, the distal-most gene of the cluster. We also identified an insertion/deletion polymorphism for a approximately 2 kb LINE1 (L1) element that occurs within intron 7 of GABRG1. Our genotype analysis amongst autism families indicated that the L1 deletion allele did not show increased transmission to affected individuals. No linkage disequilibrium was evident between the L1 and single nucleotide polymorphisms in adjacent GABA(A) receptor genes on 4p, where a recent study has identified significant association with autism. Despite this, the identification of an inversion breakpoint disrupting GABRG1 provides solid support for the genetic involvement of the short arm of chromosome 4 in the genetic aetiology of autism, and for the hypothesis of disrupted GABA neurotransmission in autism.

Direct Reactions at the Facility for Experiments on Nuclear Reactions in Stars (FENRIS)

NASA Astrophysics Data System (ADS)

Longland, Richard; Kelley, John; Marshall, Caleb; Portillo, Federico; Setoodehnia, Kiana

2017-09-01

Nuclear cross sections are a key ingredient in stellar models designed to understand how stars evolve. Determining these cross sections, therefore, is critical for obtaining reliable predictions from stellar models. While many charged-particle reaction cross sections can be measured in the laboratory, the Coulomb barrier means that they cannot always be measured at the low energies relevant to astrophysics. In other cases, radioactive targets make the measurements unfeasible. Radioactive ion beam experiments in inverse kinematics are one solution, but low beam intensities mean that cross sections plague these attempts further. Direct measurements, particularly particle transfer experiments, are one tool in our inventory that provides us with the necessary information to infer reaction cross sections at stellar energies. I will present an overview of one facility: the Facility for Experiments on Nuclear Reactions in Stars (FENRIS), which is dedicated to performing particle transfer measurements for astrophysical cross sections. Over the past few years, FENRIS has been fully upgraded and characterized. I will show highlights of our upgrade activities and current capabilities. I will also highlight our recent experimental results and discuss current upgrade efforts.

Monte-Carlo Geant4 numerical simulation of experiments at 247-MeV proton microscope

NASA Astrophysics Data System (ADS)

Kantsyrev, A. V.; Skoblyakov, A. V.; Bogdanov, A. V.; Golubev, A. A.; Shilkin, N. S.; Yuriev, D. S.; Mintsev, V. B.

2018-01-01

A radiographic facility for an investigation of fast dynamic processes with areal density of targets up to 5 g/cm2 is under development on the basis of high-current proton linear accelerator at the Institute for Nuclear Research (Troitsk, Russia). A virtual model of the proton microscope developed in a software toolkit Geant4 is presented in the article. Fullscale Monte-Carlo numerical simulation of static radiographic experiments at energy of a proton beam 247 MeV was performed. The results of simulation of proton radiography experiments with static model of shock-compressed xenon are presented. The results of visualization of copper and polymethyl methacrylate step wedges static targets also described.

Experiments, conceptual design, preliminary cost estimates and schedules for an underground research facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korbin, G.; Wollenberg, H.; Wilson, C.

Plans for an underground research facility are presented, incorporating techniques to assess the hydrological and thermomechanical response of a rock mass to the introduction and long-term isolation of radioactive waste, and to assess the effects of excavation on the hydrologic integrity of a repository and its subsequent backfill, plugging, and sealing. The project is designed to utilize existing mine or civil works for access to experimental areas and is estimated to last 8 years at a total cost for contruction and operation of $39.0 million (1981 dollars). Performing the same experiments in an existing underground research facility would reduce themore » duration to 7-1/2 years and cost $27.7 million as a lower-bound estimate. These preliminary plans and estimates should be revised after specific sites are identified which would accommodate the facility.« less

Methylation of CpG island of p14(ARK), p15(INK4b) and p16(INK4a) genes in coke oven workers.

PubMed

Zhang, H; Li, X; Ge, L; Yang, J; Sun, J; Niu, Q

2015-02-01

To detect the blood genomic DNA methylation in coke oven workers and find a possible early screening index for occupational lung cancer, 74 coke oven workers as the exposed group and 47 water pump workers as the controls were surveyed, and urine samples and peripheral blood mononuclear cells (PBMCs) were collected. Airborne benzo[a]pyrene (B[a]P) levels in workplace and urinary 1-hydroxypyrene (1-OH-Py) levels were determined by high-performance liquid chromatography. DNA damage of PBMCs and the p14(ARK), p15(INK4b) and p16(INK4a) gene CpG island methylation in the promoter region were detected by comet assay and methylation-specific polymerase chain reaction techniques, respectively. Results show that compared with the controls, concentration of airborne B[a]Ps was elevated in the coke plant, and urinary 1-OH-Py's level and DNA olive tail moment in comet assay were significantly increased in the coke oven workers, and p14(ARK), p15(INK4b) and p16(INK4a) gene methylation rates were also significantly increased. With the working years and urinary 1-OH-Py's level, the rates of p14(ARK) and p16(INK4a) gene methylation were significantly increased while that of p15(INK4b) gene methylation displayed no statistical change. We conclude that PBMCs' p14(ARK) and p16(INK4a) gene methylation may be used for screening and warning lung cancer in coke oven workers. © The Author(s) 2015.

Advances in shock timing experiments on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Robey, H. F.; Celliers, P. M.; Moody, J. D.; Sater, J.; Parham, T.; Kozioziemski, B.; Dylla-Spears, R.; Ross, J. S.; LePape, S.; Ralph, J. E.; Hohenberger, M.; Dewald, E. L.; Berzak Hopkins, L.; Kroll, J. J.; Yoxall, B. E.; Hamza, A. V.; Boehly, T. R.; Nikroo, A.; Landen, O. L.; Edwards, M. J.

2016-03-01

Recent advances in shock timing experiments and analysis techniques now enable shock measurements to be performed in cryogenic deuterium-tritium (DT) ice layered capsule implosions on the National Ignition Facility (NIF). Previous measurements of shock timing in inertial confinement fusion (ICF) implosions were performed in surrogate targets, where the solid DT ice shell and central DT gas were replaced with a continuous liquid deuterium (D2) fill. These previous experiments pose two surrogacy issues: a material surrogacy due to the difference of species (D2 vs. DT) and densities of the materials used and a geometric surrogacy due to presence of an additional interface (ice/gas) previously absent in the liquid-filled targets. This report presents experimental data and a new analysis method for validating the assumptions underlying this surrogate technique.

Facile fabrication and electrical investigations of nanostructured p-Si/n-TiO2 hetero-junction diode

NASA Astrophysics Data System (ADS)

Kumar, Arvind; Mondal, Sandip; Rao, K. S. R. Koteswara

2018-05-01

In this work, we have fabricated the nanostructured p-Si/n-TiO2 hetero-junction diode by using a facile spin-coating method. The XRD analysis suggests the presence of well crystalline anatase TiO2 film on Si with small grain size (˜16 nm). We have drawn the band alignment using Anderson model to understand the electrical transport across the junction. The current-voltage (J-V) characteristics analysis reveals the good rectification ratio (103 at ± 3 V) and slightly higher ideality factor (4.7) of our device. The interface states are responsible for the large ideality factor as Si/TiO2 form a dissimilar interface and possess a large number of dangling bonds. The study reveals the promises to be used Si/TiO2 diode as an alternative to the traditional p-n homo-junction diode, which typically require high budget.

Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.

PubMed

Marriott, Andrew S; Copeland, Nikki A; Cunningham, Ryan; Wilkinson, Mark C; McLennan, Alexander G; Jones, Nigel J

2015-09-01

The level of intracellular diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) increases several fold in mammalian cells treated with non-cytotoxic doses of interstrand DNA-crosslinking agents such as mitomycin C. It is also increased in cells lacking DNA repair proteins including XRCC1, PARP1, APTX and FANCG, while >50-fold increases (up to around 25 μM) are achieved in repair mutants exposed to mitomycin C. Part of this induced Ap4A is converted into novel derivatives, identified as mono- and di-ADP-ribosylated Ap4A. Gene knockout experiments suggest that DNA ligase III is primarily responsible for the synthesis of damage-induced Ap4A and that PARP1 and PARP2 can both catalyze its ADP-ribosylation. Degradative proteins such as aprataxin may also contribute to the increase. Using a cell-free replication system, Ap4A was found to cause a marked inhibition of the initiation of DNA replicons, while elongation was unaffected. Maximum inhibition of 70-80% was achieved with 20 μM Ap4A. Ap3A, Ap5A, Gp4G and ADP-ribosylated Ap4A were without effect. It is proposed that Ap4A acts as an important inducible ligand in the DNA damage response to prevent the replication of damaged DNA. Copyright © 2015 Elsevier B.V. All rights reserved.

Measurement of OH, H2SO4, MSA, and HNO3 Aboard the P-3B Aircraft

NASA Technical Reports Server (NTRS)

Eisele, F. L.

2003-01-01

This paper addresses the measurement of OH, H2SO4, MSA, and HNO3 aboard the P-3B aircraft under the following headings: 1) Performance Report; 2) Highlights of OH, H2SO4, and MSA Measurements Made Aboard the NASA P-3B During TRACE-P; 3) Development and characteristics of an airborne-based instrument used to measure nitric acid during the NASA TRACE-P field experiment.

[A case of mosaic ring chromosome 4 with subtelomeric 4p deletion].

PubMed

Kim, Jeong Hyun; Oh, Phil Soo; Na, Hye Yeon; Kim, Sun-Hee; Cho, Hyoun Chan

2009-02-01

Ring chromosome is a structural abnormality that is thought to be the result of fusion and breakage in the short and long arms of chromosome. Wolf-Hirschhorn syndrome (WHS) is a well-known congenital anomaly in the ring chromosome 4 with a partial deletion of the distal short arm. Here we report a 10-month-old male of mosaic ring chromosome 4 with the chief complaint of severe short stature. He showed the height of -4 standard deviation, subtle hypothyroidism and mild atrial septal defect/ventricular septal defect, and also a mild language developmental delay was suspected. Brain magnetic resonance imaging showed multifocal leukomalacia. Chromosomal analysis of the peripheral blood showed the mosaic karyotype with [46,XY,r(4)(p16q35)[84]/45,XY,-4[9]/91,XXYY, dic r(4;4)(p16q35;p16q35)[5]/46,XY,dic r(4;4)(p16q35;p16q35)[2

First internal and external experiments at COSY Juelich

NASA Astrophysics Data System (ADS)

Prasuhn, D.; Maier, R.; Bechstedt, U.; Dietrich, J.; Hacker, U.; Martin, S.; Stockhorst, H.; Tölle, R.; Grzonka, D.; Nake, C.; Mosel, F.

1995-02-01

The inauguration of the cooler synchrotron COSY Jülich was celebrated on April 1st, 1993. After the first successful acceleration to proton momenta above 800 GeV/ c, beamtimes for experiments were scheduled in parallel to further machine development. The first experiment was the internal target experiment EDDA, which investigated the energy dependence of the p-p interaction. It makes use of a 3 × 4 μm 2 thin CH 2 fiber as an internal target. The thickness of the fiber is more than adequate to achieve high luminosities, so the intensity of the stored beam has to be reduced to 10 7 p. On the other hand, it is thin enough to achieve beam lifetimes of 3 s at 1.4 GeV/ c. Details of the target fabrication and the first experimental results will be discussed. Both external experimental facilities at COSY, the time-of-flight spectrometer, and the magnetic spectrometer BIG KARL use a liquid hydrogen (deuterium) target. The first experiments were carried out at proton energies between 300 MeV and 500 MeV. Also, these experimental data will be presented. Two further internal experiments are prepared for the installation into the COSY ring. The target for the first experiment is a gas-jet target, the second experiment uses ribbon targets for the interaction. The status of both experimental setups will be shown.

SHiP: a new facility with a dedicated detector for studying tau-neutrino properties and nucleon structure functions

NASA Astrophysics Data System (ADS)

Bick, Daniel; SHiP Collaboration

2017-09-01

SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently reviewed by the CERN SPS Committee, who recommended that the experiment proceeds further to a Comprehensive Design phase. In its initial phase, the 400 GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 × 1020 pot in 5 years. A dedicated detector downstream of the target will allow to probe a variety of models with light long-lived exotic particles and masses below a few GeV/c2. Another dedicated detector will allow the study of neutrino cross-sections and angular distributions, which was the focus of the poster. ντ deep inelastic scattering cross sections will be measured with a statistics 1000 times larger than currently available, with the extraction of the F 4 and F 5 structure functions, never measured so far and allow for new tests of lepton non-universality with sensitivity to BSM physics. Moreover, ντ ’s will be distinguished from {\\displaystyle \\bar{ν }}τ ’s, thus providing the first observation of the {\\displaystyle \\bar{ν }}τ . With νµ scattering it will be possible to reduce by about 50% the current uncertainty on the strange content of the nucleon in the range of the x variable between 0.05 and 0.3, complementary to LHC measurements. The detector will be based on several techniques developed for the OPERA experiment at LNGS.

P4P4P: An Agenda for Research on Pay for Performance for Patients

PubMed Central

Volpp, Kevin G.; Pauly, Mark V.; Loewenstein, George; Bangsberg, David

2012-01-01

Unhealthy behaviors are a major cause of poor health outcomes and high health care costs. In this Commentary, we describe an agenda for research to guide broader use of patient-targeted financial incentives either in conjunction with provider-targeted financial incentives (P4P) or in clinical contexts where provider-targeted approaches are unlikely to be effective. We discuss evidence of proven effectiveness and limitations of the existing evidence, reasons for underutilization of these approaches, and options for operationalizing wider use. Patient-targeted incentives have great potential, and systematic testing will help determine how they can best be used to improve population health. PMID:19124872

The SHiP experiment at CERN

NASA Astrophysics Data System (ADS)

De Lellis, G.; SHiP Collaboration

2017-04-01

The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry of the Universe, which deserve an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experiment at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using high intensity 400 GeV protons is a copious source of such unknown particles in the GeV mass range. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. Indeed, tau anti-neutrinos have not been directly observed so far. We report the physics potential of such an experiment.

Measurement of the 21Na(p,{gamma})22Mg Reaction with the Dragon Facility at TRIUMF-ISAC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, A.A.; Bishop, S.; D'Auria, J.M.

2003-08-26

The DRAGON recoil separator facility, designed to measure the rates of radiative proton and alpha capture reactions important for nuclear astrophysics, is now operational at the TRIUMF-ISAC radioactive beam facility in Vancouver, Canada. We report on first measurements of the 21Na(p,{gamma})22Mg reaction rate with radioactive beams of 21Na.

Skylab Medical Experiments Altitude Test /SMEAT/ facility design and operation.

NASA Technical Reports Server (NTRS)

Hinners, A. H., Jr.; Correale, J. V.

1973-01-01

This paper presents the design approaches and test facility operation methods used to successfully accomplish a 56-day test for Skylab to permit evaluation of selected Skylab medical experiments in a ground test simulation of the Skylab environment with an astronaut crew. The systems designed for this test include the two-gas environmental control system, the fire suppression and detection system, equipment transfer lock, ground support equipment, safety systems, potable water system, waste management system, lighting and power system, television monitoring, communications and recreation systems, and food freezer.

Calibration of the SphinX experiment at the XACT facility in Palermo

NASA Astrophysics Data System (ADS)

Collura, A.; Barbera, M.; Varisco, S.; Calderone, G.; Reale, F.; Gburek, S.; Kowalinski, M.; Sylwester, J.; Siarkowski, M.; Bakala, J.; Podgorski, P.; Trzebinski, W.; Plocieniak, S.; Kordylewski, Z.

2008-07-01

Three of the four detectors of the SphinX experiment to be flown on the Russian mission Coronas-Photon have been measured at the XACT Facility of the Palermo Observatory at several wavelengths in the soft X-ray band. We describe the instrumental set-up and report some measurements. The analysis work to obtain the final calibration is still in progress.

Laser shock compression experiments on precompressed water in ``SG-II'' laser facility

NASA Astrophysics Data System (ADS)

Shu, Hua; Huang, Xiuguang; Ye, Junjian; Fu, Sizu

2017-06-01

Laser shock compression experiments on precompressed samples offer the possibility to obtain new hugoniot data over a significantly broader range of density-temperature phase than was previously achievable. This technique was developed in ``SG-II'' laser facility. Hugoniot data were obtained for water in 300 GPa pressure range by laser-driven shock compression of samples statically precompressed in diamond-anvil cells.

First Principles Investigation of the Geometrical and Electrochemical Properties of Na4P4P2S6

NASA Astrophysics Data System (ADS)

Rush, Larry E., Jr.; Holzwarth, N. A. W.

First principles simulations are used to examine the structural and physical properties of Na4P2S6 in comparison with its Li4P2S6 analog. Four model structures are considered including the C 2 / m structure recently reported by Kuhn and co-workers from their analysis of single crystals of Na4P2S6, and three structures related to the P63 / mcm structure with P site disorder found in 1982 by Mercier and co-workers from their analysis of single crystals of Li4P2S6. The computational results indicate that both Na4P2S6 and Li4P2S6 have the same disordered ground state structures consistent with the P63 / mcm space group, while the optimized C 2 / m structures have higher energies by 0.1 eV and 0.4 eV per formula unit for Na4P2S6 and Li4P2S6, respectively. Simulations of ion migration suggest that Na4P2S6 may have more favorable ionic conductivity compared to Li4P2S6. Supported by NSF Grant DMR-1105485 and DMR-1507942.

4p- syndrome and 9p tetrasomy mosaicism with cleft lip and palate.

PubMed

Kobayashi, J; Kimijima, Y; Yamada, S; Amagasa, T; Saito-Ohara, F

2000-06-01

Chromosome 4p- syndrome is a multiple malformation syndrome associated with partial deletion of the short arm of chromosome 4 (4p-). It is characterized by dysmorphic features and retarded development. Cleft lip and/or palate are the major clinical manifestations. Cases of tetrasomy 9p are extremely rare; the principal clinical manifestations of this condition are characteristic craniofacial abnormalities, generalized hypotonia and severe mental retardation. We present the first case of a female infant with 4p deletion and tetrasomy 9p mosaicism, exhibiting a left-sided cleft lip, alveolus and soft palate. Karyotype analysis of lymphocytes cultured from the patient revealed that she was mosaic: 86% of the cells were 46, XX, add (4) (p15.32) and 14% were 47, XX, add (4) (p15.32), +idic (9)(q12). The G-banding pattern appeared consistent with either translocation or partial proximal deletion of 4p. In order to make a definitive cytogenetic diagnosis of isodicentric chromosome 9, fluorescence in situ hybridization (FISH) was applied. At 8 months, when the patient weighed 4.3 kg, her cleft lip was repaired. Before and after surgery there were no seizures, and the postoperative course was uneventful. Copyright 2000 European Association for Cranio-Maxillofacial Surgery.

Status of the cyclotron/P.E.T. facility at the State University of New York at Buffalo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toorongian, S.A.; Haka, M.S.

1994-12-31

A new P.E.T./Cyclotron facility has been constructed on the Main St. campus of the State University of New York at Buffalo to service the needs of Nuclear Medicine departments in Buffalo and throughout the Western New York area. This facility is jointly funded and operated by S.U.N.Y. and the Veterans Administration. The cyclotron, as well as the research labs and a nuclear pharmacy to prepare non-positron emitting radiopharmaceuticals, are located in a newly constructed facility on campus. The P.E.T. scanner is located in the Veterans Administration Hospital adjacent to the campus. The two annexes are connected by a pneumatic transportmore » {open_quotes}rabbit{close_quotes} system. The cyclotron and all radiopharmaceutical synthesis apparatus have been purchased from Ion Beam Applications s.a. of Lovain-la-Neuve Belgium.« less

A new gun facility dedicated to performing shock physics and terminal ballistics experiments

NASA Astrophysics Data System (ADS)

Zakraysek, Alan J.; Sutherland, Gerrit T.; Sandusky, Harold D.; Strange, David

2000-04-01

A new building has been constructed to house various powder and single-stage and two-stage gas guns at the Naval Surface Warfare Center, Indian Head Division. Guns previously located at the Naval Research Laboratory and the former White Oak Site of the Naval Surface Warfare Center have been relocated here. Most of the guns are mounted on moveable pedestals to allow them to be shot into various chambers. The facility includes a concrete blast chamber, a target chamber/catch tank for flyer plate experiments, and a target chamber outfitted for terminal ballistics measurements. This paper will discuss the capabilities of this new facility.

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

PubMed Central

Moehring, Francie; Cowie, Ashley M; Menzel, Anthony D; Weyer, Andy D; Grzybowski, Michael; Arzua, Thiago; Geurts, Aron M; Palygin, Oleg

2018-01-01

The first point of our body’s contact with tactile stimuli (innocuous and noxious) is the epidermis, the outermost layer of skin that is largely composed of keratinocytes. Here, we sought to define the role that keratinocytes play in touch sensation in vivo and ex vivo. We show that optogenetic inhibition of keratinocytes decreases behavioral and cellular mechanosensitivity. These processes are inherently mediated by ATP signaling, as demonstrated by complementary cutaneous ATP release and degradation experiments. Specific deletion of P2X4 receptors in sensory neurons markedly decreases behavioral and primary afferent mechanical sensitivity, thus positioning keratinocyte-released ATP to sensory neuron P2X4 signaling as a critical component of baseline mammalian tactile sensation. These experiments lay a vital foundation for subsequent studies into the dysfunctional signaling that occurs in cutaneous pain and itch disorders, and ultimately, the development of novel topical therapeutics for these conditions. PMID:29336303

Microgravity Combustion Science and Fluid Physics Experiments and Facilities for the ISS

NASA Technical Reports Server (NTRS)

Lauver, Richard W.; Kohl, Fred J.; Weiland, Karen J.; Zurawski, Robert L.; Hill, Myron E.; Corban, Robert R.

2001-01-01

At the NASA Glenn Research Center, the Microgravity Science Program supports both ground-based and flight experiment research in the disciplines of Combustion Science and Fluid Physics. Combustion Science research includes the areas of gas jet diffusion flames, laminar flames, burning of droplets and misting fuels, solids and materials flammability, fire and fire suppressants, turbulent combustion, reaction kinetics, materials synthesis, and other combustion systems. The Fluid Physics discipline includes the areas of complex fluids (colloids, gels, foams, magneto-rheological fluids, non-Newtonian fluids, suspensions, granular materials), dynamics and instabilities (bubble and drop dynamics, magneto/electrohydrodynamics, electrochemical transport, geophysical flows), interfacial phenomena (wetting, capillarity, contact line hydrodynamics), and multiphase flows and phase changes (boiling and condensation, heat transfer, flow instabilities). A specialized International Space Station (ISS) facility that provides sophisticated research capabilities for these disciplines is the Fluids and Combustion Facility (FCF). The FCF consists of the Combustion Integrated Rack (CIR), the Fluids Integrated Rack (FIR) and the Shared Accommodations Rack and is designed to accomplish a large number of science investigations over the life of the ISS. The modular, multiuser facility is designed to optimize the science return within the available resources of on-orbit power, uplink/downlink capacity, crew time, upmass/downmass, volume, etc. A suite of diagnostics capabilities, with emphasis on optical techniques, will be provided to complement the capabilities of the subsystem multiuser or principal investigator-specific experiment modules. The paper will discuss the systems concept, technical capabilities, functionality, and the initial science investigations in each discipline.

An inventory of aeronautical ground research facilities. Volume 4: Engineering flight simulation facilities

NASA Technical Reports Server (NTRS)

Pirrello, C. J.; Hardin, R. D.; Capelluro, L. P.; Harrison, W. D.

1971-01-01

The general purpose capabilities of government and industry in the area of real time engineering flight simulation are discussed. The information covers computer equipment, visual systems, crew stations, and motion systems, along with brief statements of facility capabilities. Facility construction and typical operational costs are included where available. The facilities provide for economical and safe solutions to vehicle design, performance, control, and flying qualities problems of manned and unmanned flight systems.

First radioactive beams at ACCULINNA-2 facility and first proposed experiment

NASA Astrophysics Data System (ADS)

Bezbakh, A. A.; Beekman, W.; Chudoba, V.; Fomichev, A. S.; Golovkov, M. S.; Gorshkov, A. V.; Grigorenko, L. V.; Kaminski, G.; Krupko, S. A.; Mentel, M.; Nikolskii, E. Yu.; Parfenova, Yu. L.; Plucinski, P.; Sidorchuk, S. I.; Slepnev, R. S.; Sharov, P. G.; Ter-Akopian, G. M.; Zalewski, B.

2018-04-01

New fragment separator ACCULINNA-2 was installed at the primary beam line of the U-400M cyclotron in 2016. Recently, first radioactive ion beams were obtained. The design parameters of new facility were experimentally confirmed. Intensity, purity and transverse profile of several secondary beams at the final focal plane were studied. The intensities obtained for the secondary beams of 14B, 12Be, 9;11Li, 6;8He in the fragmentation reaction 15N (49.7 AMeV) + Be (2 mm) are in average 15 times higher in comparison to the ones produced at its forerunner ACCULINNA separator. The ACCULINNA-2 separator will become a backbone facility at the FLNR for the research in the field of light exotic nuclei in the vicinity of the nuclear drip lines. The planned first experiment, aimed for the observation of the 7H nucleus at ACCULINNA-2, is outlined.

Laser materials processing facility

NASA Technical Reports Server (NTRS)

Haggerty, J. S.

1982-01-01

The laser materials processing facility and its capabilities are described. A CO2 laser with continuous wave, repetitive pulse, and shaped power-time cycles is employed. The laser heated crystal growth station was used to produce metal and metal oxide single crystals and for cutting and shaping experiments using Si3N4 to displace diamond shaping processes.

Polar-direct-drive experiments on the National Ignition Facility

DOE PAGES

Hohenberger, M.; Radha, P. B.; Myatt, J. F.; ...

2015-05-11

To support direct-drive inertial confinement fusion experiments at the National Ignition Facility (NIF) [G. H. Miller, E. I. Moses, and C. R. Wuest, Opt. Eng. 43, 2841 (2004)] in its indirect-drive beam configuration, the polar-direct-drive (PDD) concept [S. Skupsky et al., Phys. Plasmas 11, 2763 (2004)] has been proposed. Ignition in PDD geometry requires direct-drive–specific beam smoothing, phase plates, and repointing the NIF beams toward the equator to ensure symmetric target irradiation. First experiments to study the energetics and preheat in PDD implosions at the NIF have been performed. These experiments utilize the NIF in its current configuration, including beammore » geometry, phase plates, and beam smoothing. Room-temperature, 2.2-mm-diam plastic shells filled with D₂ gas were imploded with total drive energies ranging from ~500 to 750 kJ with peak powers of 120 to 180 TW and peak on-target irradiances at the initial target radius from 8 10¹⁴ to 1.2 10¹⁵W/cm². Results from these initial experiments are presented, including measurements of shell trajectory, implosion symmetry, and the level of hot-electron preheat in plastic and Si ablators. Experiments are simulated with the 2-D hydrodynamics code DRACO including a full 3-D ray-trace to model oblique beams, and models for nonlocal electron transport and cross-beam energy transport (CBET). These simulations indicate that CBET affects the shell symmetry and leads to a loss of energy imparted onto the shell, consistent with the experimental data.« less

10 CFR 8.4 - Interpretation by the General Counsel: AEC jurisdiction over nuclear facilities and materials...

Code of Federal Regulations, 2012 CFR

2012-01-01

... over nuclear facilities and materials under the Atomic Energy Act. 8.4 Section 8.4 Energy NUCLEAR... nuclear facilities and materials under the Atomic Energy Act. (a) By virtue of the Atomic Energy Act of... Atomic Energy Act of 1954 sets out a pattern for licensing and regulation of certain nuclear materials...

10 CFR 8.4 - Interpretation by the General Counsel: AEC jurisdiction over nuclear facilities and materials...

Code of Federal Regulations, 2010 CFR

2010-01-01

... over nuclear facilities and materials under the Atomic Energy Act. 8.4 Section 8.4 Energy NUCLEAR... nuclear facilities and materials under the Atomic Energy Act. (a) By virtue of the Atomic Energy Act of... Atomic Energy Act of 1954 sets out a pattern for licensing and regulation of certain nuclear materials...

10 CFR 8.4 - Interpretation by the General Counsel: AEC jurisdiction over nuclear facilities and materials...

Code of Federal Regulations, 2011 CFR

2011-01-01

... over nuclear facilities and materials under the Atomic Energy Act. 8.4 Section 8.4 Energy NUCLEAR... nuclear facilities and materials under the Atomic Energy Act. (a) By virtue of the Atomic Energy Act of... Atomic Energy Act of 1954 sets out a pattern for licensing and regulation of certain nuclear materials...

Study of Multiple Scale Physics of Magnetic Reconnection on the FLARE (Facility for Laboratory Reconnection Experiments)

NASA Astrophysics Data System (ADS)

Ji, H.; Bhattacharjee, A.; Prager, S.; Daughton, W. S.; Bale, S. D.; Carter, T. A.; Crocker, N.; Drake, J. F.; Egedal, J.; Sarff, J.; Wallace, J.; Chen, Y.; Cutler, R.; Fox, W. R., II; Heitzenroeder, P.; Kalish, M.; Jara-Almonte, J.; Myers, C. E.; Ren, Y.; Yamada, M.; Yoo, J.

2015-12-01

The FLARE device (flare.pppl.gov) is a new intermediate-scale plasma experiment under construction at Princeton to study magnetic reconnection in regimes directly relevant to space, solar and astrophysical plasmas. The existing small-scale experiments have been focusing on the single X-line reconnection process either with small effective sizes or at low Lundquist numbers, but both of which are typically very large in natural plasmas. The configuration of the FLARE device is designed to provide experimental access to the new regimes involving multiple X-lines, as guided by a reconnection "phase diagram" [Ji & Daughton, PoP (2011)]. Most of major components of the FLARE device have been designed and are under construction. The device will be assembled and installed in 2016, followed by commissioning and operation in 2017. The planned research on FLARE as a user facility will be discussed on topics including the multiple scale nature of magnetic reconnection from global fluid scales to ion and electron kinetic scales. Results from scoping simulations based on particle and fluid codes and possible comparative research with space measurements will be presented.

Facile deposition of gold nanoparticles on core-shell Fe3O4@polydopamine as recyclable nanocatalyst

NASA Astrophysics Data System (ADS)

Zhao, Yan; Yeh, Yaowen; Liu, Rui; You, Jinmao; Qu, Fengli

2015-07-01

A simple and green method for the controllable synthesis of core-shell Fe3O4 polydopamine nanoparticles (Fe3O4@PDA NPs) with tunable shell thickness and their application as a recyclable nanocatalyst support is presented. Magnetite Fe3O4 NPs formed in a one-pot process by the hydrothermal approach with a diameter of ˜240 nm were coated with a polydopamine shell layer with a tunable thickness of 15-45 nm. The facile deposition of Au NPs atop Fe3O4@PDA NPs was achieved by utilizing PDA as both the reducing agent and the coupling agent. The satellite nanocatalysts exhibited high catalytic performance for the reduction of p-nitrophenol. Furthermore, the recovery and reuse of the catalyst was demonstrated 8 times without detectible loss in activity. The synergistic combination of unique features of PDA and magnetic nanoparticles establishes these core-shell NPs as a versatile platform for potential applications.

Apollo experience report: Real-time auxiliary computing facility development

NASA Technical Reports Server (NTRS)

Allday, C. E.

1972-01-01

The Apollo real time auxiliary computing function and facility were an extension of the facility used during the Gemini Program. The facility was expanded to include support of all areas of flight control, and computer programs were developed for mission and mission-simulation support. The scope of the function was expanded to include prime mission support functions in addition to engineering evaluations, and the facility became a mandatory mission support facility. The facility functioned as a full scale mission support activity until after the first manned lunar landing mission. After the Apollo 11 mission, the function and facility gradually reverted to a nonmandatory, offline, on-call operation because the real time program flexibility was increased and verified sufficiently to eliminate the need for redundant computations. The evaluation of the facility and function and recommendations for future programs are discussed in this report.

Structural Basis of CDK4 Inhibition by p18INK4

DTIC Science & Technology

1999-05-01

have determined the crystal structure of p 18INK4c to 1.95 A resolution [4] and the atomic coordinates have been deposited in the PDB protein...p 18INK4c function. The results were published [4] (Attached) and the coordinates were deposited in the PDB Protein Structure Database (Accession...Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ŘCurrent address: Institute of Molecular Agrobiology, National University of

Small Sample Reactivity Measurements in the RRR/SEG Facility: Reanalysis using TRIPOLI-4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hummel, Andrew; Palmiotti, Guiseppe

2016-08-01

This work involved reanalyzing the RRR/SEG integral experiments performed at the Rossendorf facility in Germany throughout the 1970s and 80s. These small sample reactivity worth measurements were carried out using the pile oscillator technique for many different fission products, structural materials, and standards. The coupled fast-thermal system was designed such that the measurements would provide insight into elemental data, specifically the competing effects between neutron capture and scatter. Comparing the measured to calculated reactivity values can then provide adjustment criteria to ultimately improve nuclear data for fast reactor designs. Due to the extremely small reactivity effects measured (typically less thanmore » 1 pcm) and the specific heterogeneity of the core, the tool chosen for this analysis was TRIPOLI-4. This code allows for high fidelity 3-dimensional geometric modeling, and the most recent, unreleased version, is capable of exact perturbation theory.« less

Effect of NH4-N/P and Ca/P molar ratios on the reactive crystallization of calcium phosphates for phosphorus recovery from wastewater

NASA Astrophysics Data System (ADS)

Vasenko, Liubov; Qu, Haiyan

2017-02-01

In this work, the effects of operational parameters, initial phosphorus concentration and molar ratios of Ca/P and NH4-N/P (further in the text N/P), on the nature and purity of precipitated phosphorus products have been investigated in an artificial system that mimics the supernatant in wastewater treatment plants. Metastable zone width was determined for two target phosphorus products: DCPD (dicalcium phosphate dihydrate) and HAp (hydroxyapatite) in the range of pH 4.5 - 7. HAp crystallizes at final pH higher than 6.3 while DCPD crystallizes at the final pH in between 4.7 and 5.7. At the final pH 5.7 - 6.3 and at pH lower than 4.7 the mixtures of DCPD and HAp were obtained. It was observed that N/P ratio affects not only the metastable zone width but also the kinetics of crystal growth for both DCPD and HAp: the higher the N/P ratio, the lower is the growth rate for both P-products. Investigation of the effect of Ca/P and N/P ratios on the nucleation and crystal growth of DCPD in batch crystallization experiment was performed. It showed that at high supersaturation level, crystals with larger median size can be obtained at higher N/P ratio despite the negative effects of N/P ratio on the growth rate of the crystals.

Role of the metabotropic P2Y(4) receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor.

PubMed

Cavaliere, Fabio; Amadio, Susanna; Angelini, Daniela F; Sancesario, Giuseppe; Bernardi, Giorgio; Volonté, Cinzia

2004-10-15

It is well established that both extracellular ATP and glutamate exert a critical role during metabolic impairment, that several P2 receptor subunits are directly involved in this action and that a strong relationship exists between glutamatergic and purinergic signals. Therefore, here we studied the molecular behavior of the purinergic metabotropic P2Y(4) and the glutamatergic ionotropic NMDAR1 receptors during hypoglycemic cell death. We find that these proteins are oppositely modulated during glucose starvation (P2Y(4) is induced, whereas NMDAR1 is inhibited) and that both P2 and NMDA antagonists can restore basal protein expression levels. Moreover, double immunofluorescence experiments with confocal laser microscopy reveal co-localization at the membrane level between the P2Y(4) and NMDAR1 receptors, in both homologous (cerebellar granule neurons) and heterologous (Hek-293) cellular systems. This is furthermore confirmed by co-immunoprecipitation experiments. Finally, when we express the P2Y(4) receptor in the heterologous SH-SY5Y neuronal cell line, hypoglycemia then causes severe cell death and simultaneous downregulation of the NMDAR1 protein. In summary, our work establishes a potential molecular interplay between P2Y(4) and NMDAR1 receptors during glucose deprivation and the causative role of the P2Y(4) during cell death.

Conceptual design of initial opacity experiments on the national ignition facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heeter, R.  F.; Bailey, J.  E.; Craxton, R.  S.

Accurate models of X-ray absorption and re-emission in partly stripped ions are necessary to calculate the structure of stars, the performance of hohlraums for inertial confinement fusion and many other systems in high-energy-density plasma physics. Despite theoretical progress, a persistent discrepancy exists with recent experiments at the Sandia Z facility studying iron in conditions characteristic of the solar radiative–convective transition region. The increased iron opacity measured at Z could help resolve a longstanding issue with the standard solar model, but requires a radical departure for opacity theory. To replicate the Z measurements, an opacity experiment has been designed for the National Facility (NIF). The design uses established techniques scaled to NIF. A laser-heated hohlraum will produce X-ray-heated uniform iron plasmas in local thermodynamic equilibrium (LTE) at temperaturesmore » $${\\geqslant}150$$ eV and electron densities$${\\geqslant}7\\times 10^{21}~\\text{cm}^{-3}$$. The iron will be probed using continuum X-rays emitted in a$${\\sim}200$$ ps,$${\\sim}200~\\unicode[STIX]{x03BC}\\text{m}$$diameter source from a 2 mm diameter polystyrene (CH) capsule implosion. In this design,$2/3$$of the NIF beams deliver 500 kJ to the$${\\sim}6$$ mm diameter hohlraum, and the remaining$$1/3$directly drive the CH capsule with 200 kJ. Calculations indicate this capsule backlighter should outshine the iron sample, delivering a point-projection transmission opacity measurement to a time-integrated X-ray spectrometer viewing down the hohlraum axis. Preliminary experiments to develop the backlighter and hohlraum are underway, informing simulated measurements to guide the final design.« less

Distortions in 2p4d Partial Fluorescence yield for 4d elements

NASA Astrophysics Data System (ADS)

Price, Alexander; de Groot, Frank; Datta, Trinanjan

2014-03-01

X-ray absorption spectroscopy (XAS) is a standard tool to determine the electronic structure of molecules and materials. CTM4XAS and CTM4RIXS are semi-empirical programs to analyze transition metal L - and M - edge transitions by evaluating the effects of crystal field and charge transfer parameters on the atomic multiplets. We compute and compare the XAS and the fluorescence yield (FY) XAS, of the 3d and 4d transition metal ions. In the case of 2p edges of 3d elements Auger decay dominates and sets the time scale. The 2p3d X -ray emission spectra (XES) accounts for approximately 80% of the radiative decay. The 2p3d partial FY is distorted and because it dominates the FY, the total FY is also distorted. For the 4d elements the 2p4d XES decay is approximately 10% of 2p3d XES decay, implying that (the energy-constant) core-core XES and Auger channels dominate the decay. The computed 2p4d partial FY -XAS spectra are different from the 2p XAS. Although 2p4d partial FY is distorted, the total FY is not because it is dominated by 2p3d XES. We also find that the 2p3s and 2p4s XES channels contribute less than 1% and can be neglected. Cottrell Research Corporation.

A cross sectional comparison of postnatal care quality in facilities participating in a maternal health voucher program versus non-voucher facilities in Kenya.

PubMed

Warren, Charlotte E; Abuya, Timothy; Kanya, Lucy; Obare, Francis; Njuki, Rebecca; Temmerman, Marleen; Bellows, Ben

2015-07-24

Health service fees constitute substantial barriers for women seeking childbirth and postnatal care. In an effort to reduce health inequities, the government of Kenya in 2006 introduced the output-based approach (OBA), or voucher programme, to increase poor women's access to quality Safe Motherhood services including postnatal care. To help improve service quality, OBA programmes purchase services on behalf of the poor and marginalised, with provider reimbursements for verified services. Kenya's programme accredited health facilities in three districts as well as in two informal Nairobi settlements. Postnatal care quality in voucher health facilities (n = 21) accredited in 2006 and in similar non-voucher health facilities (n = 20) are compared with cross sectional data collected in 2010. Summary scores for quality were calculated as additive sums of specific aspects of each attribute (structure, process, outcome). Measures of effect were assessed in a linear regression model accounting for clustering at facility level. Data were analysed using Stata 11.0. The overall quality of postnatal care is poor in voucher and non-voucher facilities, but many facilities demonstrated 'readiness' for postnatal care (structural attributes: infrastructure, equipment, supplies, staffing, training) indicated by high scores (83/111), with public voucher facilities scoring higher than public non-voucher facilities. The two groups of facilities evinced no significant differences in postnatal care mean process scores: 14.2/55 in voucher facilities versus 16.4/55 in non-voucher facilities; coefficient: -1.70 (-4.9, 1.5), p = 0.294. Significantly more newborns were seen within 48 hours (83.5% versus 72.1%: p = 0.001) and received Bacillus Calmette-Guerin (BCG) (82.5% versus 76.5%: p < 0.001) at voucher facilities than at non-voucher facilities. Four years after facility accreditation in Kenya, scores for postnatal care quality are low in all facilities, even those with Safe Motherhood

Study of energetic particle dynamics in Harbin Dipole eXperiment (HDX) on Space Plasma Environment Research Facility (SPERF)

NASA Astrophysics Data System (ADS)

Zhibin, W.; Xiao, Q.; Wang, X.; Xiao, C.; Zheng, J.; E, P.; Ji, H.; Ding, W.; Lu, Q.; Ren, Y.; Mao, A.

2015-12-01

Zhibin Wang1, Qingmei Xiao1, Xiaogang Wang1, Chijie Xiao2, Jinxing Zheng3, Peng E1, Hantao Ji1,5, Weixing Ding4, Quaming Lu6, Y. Ren1,5, Aohua Mao11 Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, Harbin, China 150001 2 State Key Lab of Nuclear Physics & Technology, and School of Physics, Peking University, Beijing, China 100871 3ASIPP, Hefei, China, 230031 4University of California at Los Angeles, Los Angeles, CA, 90095 5Princeton Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 6University of Science and Technology of China, Hefei, China, 230026 A new terrella device for laboratory studies of space physics relevant to the inner magnetospheric plasmas, Harbin Dipole eXperiment (HDX), is scheduled to be built at Harbin Institute of Technology (HIT), China. HDX is one of two essential parts of Space Plasma Environment Research Facility (SPERF), which is a major national research facility for space physics studies. HDX is designed to provide a laboratory experimental platform to reproduce the earth's magnetospheric structure for investigations on the mechanism of acceleration/loss and wave-particle interaction of energetic particles in radiation belt, and on the influence of magnetic storms on the inner magnetosphere. It can be operated together with Harbin Reconnection eXperiment (HRX), which is another part of SPERF, to study the fundamental processes during interactions between solar wind and Earth's magnetosphere. In this presentation, the scientific goals and experimental plans for HDX, together with the means applied to generate the plasma with desired parameters, including multiple plasma sources and different kinds of coils with specific functions, as well as advanced diagnostics designed to be equipped to the facility for multi-functions, are reviewed. Three typical scenarios of HDX with operations of various coils and plasma sources to study specific physical processes in space plasmas will also be

Experiments and appropriate facilities for plant physiology research in space

NASA Astrophysics Data System (ADS)

Lork, W.

Light is a very essential parameter in a plant's life. Changing the quality and/or quantity of illumination will not only determine the further development (photomorphogenesis), but also effect spontaneous responses like curvatures (phototropism). But there are several still unknown links in the signal transduction chain from the perception of the light signals to the terminal response. It is known from ground-based experiments, that part of this signal transduction path is congruous with that of gravitational signals. Biosample is a technology development programme, which enables sophisticated experiments with whole plants in a microgravity environment. It allows complex sequences of gravitational- and light-stimuli with simultaneous recording of the plant's response (e.g. curvature of the stem) by video. This facility in union with new genetic mutants, which are less- or insensitive to light, gravity or both, are convenient tools for progress in plant physiology research.

P1,P4-diadenosine tetraphosphate (Ap4A) inhibits proximal tubular reabsorption of sodium in rats.

PubMed

Stiepanow-Trzeciak, Anna; Jankowski, Maciej; Angielski, Stefan; Szczepanska-Konkel, Miroslawa

2007-01-01

P1,P4-diadenosine tetraphosphate (Ap4A) is a vasoactive dinucleotide possessing natriuretic activity. It is unclear, however, which part of the nephron is the target site of action for Ap4A. We evaluated the tubular sites of Ap4A action using the lithium clearance technique. Ap4A at a priming dose of 2 micromol/kg with subsequent infusion at 20 nmol/kg/min increased fractional water and sodium excretion 2.5- and 5.6-fold, respectively. Moreover, Ap4A increased lithium clearance 1.9-fold and fractional lithium excretion 2.8-fold. Fractional water and sodium excretion from distal nephron segments was not significantly affected by Ap4A. These results suggest that Ap4A induces natriuresis mainly through inhibition of proximal tubular reabsorption of sodium. Copyright 2007 S. Karger AG, Basel.

4. PROPOSED C1 ASSEMBLY AND TESTING FACILITIES FOR THE ORDINANCE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. PROPOSED C-1 ASSEMBLY AND TESTING FACILITIES FOR THE ORDINANCE GUIDED MISSILE CENTER AT REDSTONE ARSENAL, NEAR THE SOUTH END OF MADKIN MOUNTAIN. OCTOBER 1950, HANNES LUEHRSEN COLLECTION, MSFC MASTER PLANNING OFFICE. - Marshall Space Flight Center, East Test Area, Dodd Road, Huntsville, Madison County, AL

Payment methods for outpatient care facilities

PubMed Central

Yuan, Beibei; He, Li; Meng, Qingyue; Jia, Liying

2017-01-01

trials, non-randomised trials, controlled before-after studies, interrupted time series, and repeated measures studies that compared different payment methods for outpatient health facilities. We defined outpatient care facilities in this review as facilities that provide health services to individuals who do not require hospitalisation or institutionalisation. We only included methods used to transfer funds from the purchaser of healthcare services to health facilities (including groups of individual professionals). These include global budgets, line-item budgets, capitation, fee-for-service (fixed and unconstrained), pay for performance, and mixed payment. The primary outcomes were service provision outcomes, patient outcomes, healthcare provider outcomes, costs for providers, and any adverse effects. Data collection and analysis At least two review authors independently extracted data and assessed the risk of bias. We conducted a structured synthesis. We first categorised the comparisons and outcomes and then described the effects of different types of payment methods on different categories of outcomes. We used a fixed-effect model for meta-analysis within a study if a study included more than one indicator in the same category of outcomes. We used a random-effects model for meta-analysis across studies. If the data for meta-analysis were not available in some studies, we calculated the median and interquartile range. We reported the risk ratio (RR) for dichotomous outcomes and the relative change for continuous outcomes. Main results We included 21 studies from Afghanistan, Burundi, China, Democratic Republic of Congo, Rwanda, Tanzania, the United Kingdom, and the United States of health facilities providing primary health care and mental health care. There were three kinds of payment comparisons. 1) Pay for performance (P4P) combined with some existing payment method (capitation or different kinds of input-based payment) compared to the existing payment method We

The National Ignition Facility (NIF) as a User Facility

NASA Astrophysics Data System (ADS)

Keane, Christopher; NIF Team

2013-10-01

The National Ignition Facility (NIF) has made significant progress towards operation as a user facility. Through June 2013, NIF conducted over 1200 experiments in support of ICF, HED science, and development of facility capabilities. The NIF laser has met or achieved all specifications and a wide variety of diagnostic and target fabrication capabilities are in place. A NIF User Group and associated Executive Board have been formed. Two User Group meetings have been conducted since formation of the User Group. NIF experiments in fundamental science have provided important new results. NIF ramp compression experiments have been conducted using diamond and iron, with EOS results obtained at pressures up to approximately 50 Mbar and 8 Mbar, respectively. Initial experiments in supernova hydrodynamics, the fundamental physics of the Rayleigh-Taylor instability, and equation of state in the Gbar pressure regime have also been conducted. This presentation will discuss the fundamental science program at NIF, including the proposal solicitation and scientific review processes and other aspects of user facility operation. This work was performed under the auspices of the Lawrence Livermore National Security, LLC, (LLNS) under Contract No. DE-AC52-07NA27344.

The National Ignition Facility: Transition to a User Facility

NASA Astrophysics Data System (ADS)

Moses, E. I.; Atherton, J.; Lagin, L.; Larson, D.; Keane, C.; MacGowan, B.; Patterson, R.; Spaeth, M.; Van Wonterghem, B.; Wegner, P.; Kauffman, R.

2016-03-01

The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) has been operational since March 2009 and has been transitioning to a user facility supporting ignition science, high energy density science (HEDS), national security applications, and fundamental science. The facility has achieved its design goal of 1.8 MJ and 500 TW of 3ω light on target, and has performed target experiments with 1.9 MJ at peak powers of 410 TW. The facility is on track to perform over 200 target shots this year in support of all of its user communities. The facility has nearly 60 diagnostic systems operational and has shown flexibility in laser pulse shape and performance to meet the requirements of its multiple users. Progress continues on its goal of demonstrating thermonuclear burn in the laboratory. It has performed over 40 indirect-drive experiments with cryogenic-layered capsules. New platforms are being developed for HEDS and fundamental science. Equation-of-state and material strength experiments have been done on a number of materials with pressures of over 50 MBars obtained in diamond, conditions never previously encountered in the laboratory and similar to those found in planetary interiors. Experiments are also in progress investigating radiation transport, hydrodynamic instabilities, and direct drive implosions. NIF continues to develop as an experimental facility. Advanced Radiographic Capability (ARC) is now being installed on NIF for producing high-energy radiographs of the imploded cores of ignition targets and for short pulse laser-plasma interaction experiments. One NIF beam is planned for conversion to two picosecond beams in 2014. Other new diagnostics such as x-ray Thomson scattering, low energy neutron spectrometer, and multi-layer reflecting x-ray optics are also planned. Incremental improvements in laser performance such as improved optics damage performance, beam balance, and back reflection control are being pursued.

Synthesis of an allergy inducing tetrasaccharide "4P-X".

PubMed

Moriya, Takashi; Nagahata, Naoki; Odaka, Rei; Nakamura, Hirohide; Yoshikawa, Jun; Kurashima, Katsumi; Saito, Tadao

2017-02-01

4P-X (β-D-galactopyranosyl-(1 → 4)-β-D-galactopyranosyl-(1 → 6)-[β-D-galactopyranosyl-(1 → 4)]-β-D-glucopyranose) is included in galacto-oligosaccharides (GOSs) produced by β-galactosidase derived from Bacillus circulans. 4P-X has been known to induce particularly strong allergies. High purity 4P-X is essential for use as a standard to quantify the amount of 4P-X in GOSs; however, the isolation of high purity 4P-X has never been reported. In this study, we achieved the synthesis of 4P-X by a combination of organic and enzymatic chemical syntheses in a short time. This is the first report of isolated, high purity 4P-X. Copyright © 2017 Elsevier Ltd. All rights reserved.

Facile synthesis and characterization of erythrocyte-like Y-doped PbWO{sub 4} mesocrystals and their photocatalytic activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiong, Ying; Wang, Bing; Hu, Wenyuan

2015-07-15

Novel erythrocyte-like Y-doped PbWO{sub 4} mesocrystals with average diameter and thickness of 1.5 and 0.7 μm are fabricated via a facile co-precipitation route at room temperature in the ethylene glycol (EG)-water mixed solvent. Time-dependent samples centrifuged at different times are carefully characterized by powder X-ray diffraction (pXRD), field-emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HRTEM) and Raman spectrum. The possible formation mechanism for the novel erythrocyte-like mesocrystals is proposed on the basis of these observations. The photocatalytic activity of the Y-doped PbWO{sub 4} mesocrystals is further investigated in terms of the degradation of the acid orange II undermore » UV irradiation. This simple and environment-friendly strategy presented here offers promising route for the synthesis of other inorganic materials with unique morphologies and interesting properties. - Graphical abstract: Display Omitted - Highlights: • Novel erythrocyte-like Y-doped PbWO{sub 4} mesocrystals are firstly synthesized via a facile co-precipitation route. • The mesocrystals are assembled by small nanoparticles a common crystallographic fashion. • The erythrocyte-like mesocrystals exhibit well photocatalytic activity. • A recrystallization-growth-oriented attachment formation mechanism is proposed.« less

Exploring health facilities' experiences in implementing the free health-care policy (FHCP) in Nepal: how did organizational factors influence the implementation of the user-fee abolition policy?

PubMed

Sato, Midori; Gilson, Lucy

2015-12-01

This article presents an Asian experience of abolishing health-care user fees: Nepal's universal free health-care policy, implemented in 2008. Based on doctoral fieldwork between August 2008 and April 2009, the paper analyses primary-care facilities' and central and district health systems' experiences with the policy. It makes a unique contribution to existing evidence because it explicitly applies organizational theory within a carefully designed, rigorous, multiple case-study analysis to deepen our understanding of the organizational and 'people' factors in the successful removal of user fees. The cases were two pairs of primary-care facilities in one district, paired for comparison of the facilities' experiences with the policy in relation to its effects on health care utilization. Data collection methods included document reviews; key informant interviews at district and central levels; in-depth, semi-structured interviews and group interviews at case facilities. (Data on indicators of utilization and quality changes over time were also collected and will be published separately). Using key elements of Nadler and Tushman's 'Organizational Congruence' model, a degree-of-fit analysis tested the study's initial propositions and yielded generalizations for contexts in and outside Nepal. The study found that Nepal's key implementation challenges were similar to Africa's: insufficient or delayed inputs of drugs and compensation; insufficient workforce and the resulting reduced quality of services that hampered facilities' relationships with their clients and health providers' attitudes. However, the Nepalese case facilities with (1) good intra- and inter-facility relationships, (2) adequate staffing, (3) well-oriented providers and (4) previously trained, better-informed and skilled health management committees experienced higher utilization and better-quality indicators over time. Through its detailed analysis of Nepal's experience in removing user fees, the study

Experimental and first-principles calculation study of the pressure-induced transitions to a metastable phase in GaP O4 and in the solid solution AlP O4-GaP O4

NASA Astrophysics Data System (ADS)

Angot, E.; Huang, B.; Levelut, C.; Le Parc, R.; Hermet, P.; Pereira, A. S.; Aquilanti, G.; Frapper, G.; Cambon, O.; Haines, J.

2017-08-01

α -Quartz-type gallium phosphate and representative compositions in the AlP O4-GaP O4 solid solution were studied by x-ray powder diffraction and absorption spectroscopy, Raman scattering, and by first-principles calculations up to pressures of close to 30 GPa. A phase transition to a metastable orthorhombic high-pressure phase along with some of the stable orthorhombic C m c m CrV O4 -type material is found to occur beginning at 9 GPa at 320 ∘C in GaP O4 . In the case of the AlP O4-GaP O4 solid solution at room temperature, only the metastable orthorhombic phase was obtained above 10 GPa. The possible crystal structures of the high-pressure forms of GaP O4 were predicted from first-principles calculations and the evolutionary algorithm USPEX. A predicted orthorhombic structure with a P m n 21 space group with the gallium in sixfold and phosphorus in fourfold coordination was found to be in the best agreement with the combined experimental data from x-ray diffraction and absorption and Raman spectroscopy. This method is found to very powerful to better understand competition between different phase transition pathways at high pressure.

48 CFR 215.404-71-4 - Facilities capital employed.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and equipment, as derived in DD Form 1861, Contract Facilities Capital Cost of Money. (i) In addition... facilities capital, the allocated facilities capital attributable to the buildings and equipment of those... Equipment 17.5 10 to 25 (g) Evaluation criteria. (1) In evaluating facilities capital employed, the...

An overview of the GOLD experiment between the ETS-6 satellite and the table mountain facility

NASA Technical Reports Server (NTRS)

Wilson, K. E.

1996-01-01

The Ground/Orbiter Lasercomm Demonstration (GOLD) is a demonstration of optical communications between the Japanese Engineering Test Satellite (ETS-VI) and an optical ground transmitting and receiving station at the Table Mountain Facility in Wrightwood, California. Laser transmissions to the satellite are performed for approximately 4 hours every third night when the satellite is at apogee above Table Mountain. The experiment requires the coordination of resources at the Communications Research Laboratory (CRL), JPL, the National Aeronautics and Space Development Agency (NASDA) Tsukuba tracking station, and NASA's Deep Space Network at Goldstone, California, to generate and transmit real-time commands and receive telemetry from the ETS-VI. Transmissions to the ETS-VI began in November 1995 and are scheduled to last into the middle of January 1996, when the satellite is expected to be eclipsed by the Earth's shadow for a major part of its orbit. The eclipse is expected to last for about 2 months, and during this period there will be limited electrical power available on board the satellite. NASDA plans to restrict experiments with the ETS-VI during this period, and no laser transmissions are planned. Posteclipse experiments are currently being negotiated. GOLD is a joint NASA-CRL experiment that is being conducted by JPL in coordination with CRL and NASDA.

An Overview of the GOLD Experiment Between the ETS-6 Satellite and the Table Mountain Facility

NASA Technical Reports Server (NTRS)

Wilson, K. E.

1996-01-01

The Ground/Orbiter Lasercomm Demonstration is a demonstration of optical communications between the Japanese Engineering Test Satellite (ETS-VI) and an optical ground transmitting and receiving station at the Table Mountain Facility in Wrightwood, California. Laser transmissions to the satellite are performed for approximately 4 hours every third night when the satellite is at apogee above Table Mountain. The experiment requires the coordination of resources at the Communications Research Laboratory (CRL), JPL, the National Aeronautics and Space Development Agency (NASDA) Tsukuba tracking station, and NASA's Deep Space Network at Goldstone, California, to generate and transmit real-time commands and receive telemetry from the ETS-VI. Transmissions to the ETS-VI began in November 1995 and are scheduled to last into the middle of January 1996, when the satellite is expected to be eclipsed by the Earth's shadow for a major part of its orbit. The eclipse is expected to last for about 2 months, and during this period there will be limited electrical power available on board the satellite. NASDA plans to restrict experiments with the ETS-VI during this period, and no laser transmissions are planned. Posteclipse experiments are currently being negotiated. GOLD is a joint NASA-CRL experiment that is being conducted by JPL in coordination with CRL and NASDA.

Gas-Grain Simulation Facility (GGSF). Volume 1: Stage 1 facility definition studies

NASA Technical Reports Server (NTRS)

Gat, Nahum

1993-01-01

The Gas-Grain Simulation Facility (GGSF) is a facility-type payload to be included in the Space Station Freedom (SSF). The GGSF is a multidisciplinary facility that will accommodate several classes of experiments, including exobiology, planetary science, atmospheric science, and astrophysics. The physical mechanisms envisioned to be investigated include crystal growth, aggregation, nucleation, coagulation, condensation, collisions, fractal growth, cycles of freezing and evaporation, scavenging, longevity of bacteria, and more. TRW performed a Phase A study that included analyses of the science and technical (S&T) requirements, the development of facility functional requirements, and a conceptual design of the facility. The work that was performed under Stage 1 of the Phase A study and the results to date are summarized. In this stage, facility definition studies were conducted in sufficient detail to establish the technical feasibility of the candidate strawman experiments. The studies identified technical difficulties, identified required facility subsystems, surveyed existing technology studies and established preliminary facility weight, volume, power consumption, data systems, interface definition, and crew time requirements. The results of this study served as the basis for Stage 2 of the Phase A study in which a conceptual design and a reference design were performed. The results also served as a basis for a related study for a Gas-Grain Simulation Experiment Module (GGSEM), which is an apparatus intended to perform a subset of the GGSF experiments on board a low-Earth-orbiting platform.

Hierarchical CoP/Ni 5 P 4 /CoP microsheet arrays as a robust pH-universal electrocatalyst for efficient hydrogen generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mishra, Ishwar Kumar; Zhou, Haiqing; Sun, Jingying

Exceptional Pt-like electrocatalytic activity was achieved in a sandwich-like catalyst of CoP/Ni 5 P 4 /CoP microsheet arrays for pH-universal hydrogen evolution through simply wrapping Ni 5 P 4 nanosheet arrays in CoP nanoparticles.

Hierarchical CoP/Ni 5 P 4 /CoP microsheet arrays as a robust pH-universal electrocatalyst for efficient hydrogen generation

DOE PAGES

Mishra, Ishwar Kumar; Zhou, Haiqing; Sun, Jingying; ...

2018-01-01

Exceptional Pt-like electrocatalytic activity was achieved in a sandwich-like catalyst of CoP/Ni 5 P 4 /CoP microsheet arrays for pH-universal hydrogen evolution through simply wrapping Ni 5 P 4 nanosheet arrays in CoP nanoparticles.

Downgrading Nuclear Facilities to Radiological Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarry, Jeffrey F.; Farr, Jesse Oscar; Duran, Leroy

2015-08-01

Based on inventory reductions and the use of alternate storage facilities, the Sandia National Laboratories (SNL) downgraded 4 SNL Hazard Category 3 (HC-3) nuclear facilities to less-than-HC-3 radiological facilities. SNL’s Waste Management and Pollution Prevention Department (WMPPD) managed the HC-3 nuclear facilities and implemented the downgrade. This paper will examine the downgrade process,

Reliable Facility Location Problem with Facility Protection

PubMed Central

Tang, Luohao; Zhu, Cheng; Lin, Zaili; Shi, Jianmai; Zhang, Weiming

2016-01-01

This paper studies a reliable facility location problem with facility protection that aims to hedge against random facility disruptions by both strategically protecting some facilities and using backup facilities for the demands. An Integer Programming model is proposed for this problem, in which the failure probabilities of facilities are site-specific. A solution approach combining Lagrangian Relaxation and local search is proposed and is demonstrated to be both effective and efficient based on computational experiments on random numerical examples with 49, 88, 150 and 263 nodes in the network. A real case study for a 100-city network in Hunan province, China, is presented, based on which the properties of the model are discussed and some managerial insights are analyzed. PMID:27583542

Summary of 2016 Light Microscopy Module (LMM) Physical Science Experiments on ISS. Update of LMM Science Experiments and Facility Capabilities

NASA Technical Reports Server (NTRS)

Sicker, Ronald J.; Meyer, William V.; Foster, William M.; Fletcher, William A.; Williams, Stuart J.; Lee, Chang-Soo

2016-01-01

This presentation will feature a series of short, entertaining, and informative videos that describe the current status and science support for the Light Microscopy Module (LMM) facility on the International Space Station. These interviews will focus on current experiments and provide an overview of future capabilities. The recently completed experiments include nano-particle haloing, 3-D self-assembly with Janus particles and a model system for nano-particle drug delivery. The videos will share perspectives from the scientists, engineers, and managers working with the NASA Light Microscopy program.

Biotechnology Facility: An ISS Microgravity Research Facility

NASA Technical Reports Server (NTRS)

Gonda, Steve R.; Tsao, Yow-Min

2000-01-01

The International Space Station (ISS) will support several facilities dedicated to scientific research. One such facility, the Biotechnology Facility (BTF), is sponsored by the Microgravity Sciences and Applications Division (MSAD) and developed at NASA's Johnson Space Center. The BTF is scheduled for delivery to the ISS via Space Shuttle in April 2005. The purpose of the BTF is to provide: (1) the support structure and integration capabilities for the individual modules in which biotechnology experiments will be performed, (2) the capability for human-tended, repetitive, long-duration biotechnology experiments, and (3) opportunities to perform repetitive experiments in a short period by allowing continuous access to microgravity. The MSAD has identified cell culture and tissue engineering, protein crystal growth, and fundamentals of biotechnology as areas that contain promising opportunities for significant advancements through low-gravity experiments. The focus of this coordinated ground- and space-based research program is the use of the low-gravity environment of space to conduct fundamental investigations leading to major advances in the understanding of basic and applied biotechnology. Results from planned investigations can be used in applications ranging from rational drug design and testing, cancer diagnosis and treatments and tissue engineering leading to replacement tissues.

Underwater Facilities Inspections and Assessments at Philadelphia Naval Shipyard, Philadelphia, Pennsylvania. Volume 1.

DTIC Science & Technology

1983-10-01

NAVAL FACILITIES ENGINEERING COMMAND~ CORPORATION .𔃾CN C 33 pItLAOFLPHI* NAVAL SH4IP-110 PŕiIL -~~NA IA I 1OAQ 4C-14723, C-13041o, C- 13047 4C-1~3046...5ECTION 2 4 8 10 ATI i I 70 30 0 .50SCALE OF FEET GOAHI FCALE CHESAPEAKE DIVISION GRAPIC SALENAVAL FACILITIES ENGINEERING COMMAND C-DLS E.GINEERING...ELEVATION CORE LCC- ATI ~J 45+00 444-50 44+00 493+50 loyo OF V 1 11 FILE’ NV~ 45+0(o / 10 5TA � TIMBER 51NEETIW4& BATTER FILI c 0 - r, - Q Q -Q Q Q -Q- ’~ rP

A fault injection experiment using the AIRLAB Diagnostic Emulation Facility

NASA Technical Reports Server (NTRS)

Baker, Robert; Mangum, Scott; Scheper, Charlotte

1988-01-01

The preparation for, conduct of, and results of a simulation based fault injection experiment conducted using the AIRLAB Diagnostic Emulation facilities is described. An objective of this experiment was to determine the effectiveness of the diagnostic self-test sequences used to uncover latent faults in a logic network providing the key fault tolerance features for a flight control computer. Another objective was to develop methods, tools, and techniques for conducting the experiment. More than 1600 faults were injected into a logic gate level model of the Data Communicator/Interstage (C/I). For each fault injected, diagnostic self-test sequences consisting of over 300 test vectors were supplied to the C/I model as inputs. For each test vector within a test sequence, the outputs from the C/I model were compared to the outputs of a fault free C/I. If the outputs differed, the fault was considered detectable for the given test vector. These results were then analyzed to determine the effectiveness of some test sequences. The results established coverage of selt-test diagnostics, identified areas in the C/I logic where the tests did not locate faults, and suggest fault latency reduction opportunities.

Clinical Significance of p53 and p16(ink4a) Status in a Contemporary North American Penile Carcinoma Cohort.

PubMed

Zargar-Shoshtari, Kamran; Spiess, Philippe E; Berglund, Anders E; Sharma, Pranav; Powsang, Julio M; Giuliano, Anna; Magliocco, Anthony M; Dhillon, Jasreman

2016-08-01

Because of the low incidence of penile carcinoma (PC), the value of p16(ink4a), p53, and human papilloma virus (HPV) infection status in clinical practice remains unclear. Herein, we report our experience with potential clinical utility of these markers in men with PC treated at our institution. Tissue microarrays of 57 cases of invasive penile squamous cell carcinomas were immunohistochemically stained for p16 and p53. HPV in situ hybridization (ISH) for high-risk subtypes was also performed. Association between marker status, nodal disease, overall (OS) and cancer-specific survival (CSS) were assessed. p16 and HPV ISH were positive in 23 (40%) and 24 (42%) of the cohort, respectively. The proportion of warty, basaloid, or mixed warty basaloid tumor subtypes were significantly greater in the p16-positive patients (48% vs. 3%; P < .01). p53 expression was negative in 31 (54%) cases. Only in p16-negative patients, positive p53 status was associated with pN+ disease (odds ratio, 4.4 [95% confidence interval (CI), 1.04-18.6]). In Kaplan-Meier analysis, the unadjusted estimated OS was insignificantly longer in p16-positive patients (median OS, 75 vs. 27 months; P = .27) and median CSS was not reached (P = .16). In a multivariable Cox proportional hazard model, when controlling for pathological nodal status and adjuvant chemotherapy, p16 status was a significant predictor for improved CSS (hazard ratio, 0.36 [95% CI, 0.13-0.99]). The worst CSS was seen in pN+ patients with double negative p16 and p53 expression (8 vs. 34 months; P = .01). In this current cohort, p53 and p16 status showed clinical utility in predicting nodal disease as well as survival. Copyright © 2015 Elsevier Inc. All rights reserved.

Application experiments to trace N-P interactions in forest ecosystems

NASA Astrophysics Data System (ADS)

Krüger, Jaane; Niederberger, Jörg; Schulz, Stefanie; Lang, Friederike

2017-04-01

Phosphorus is a limited resource and there is increasing debate regarding the principles of tight P recycling. Forest ecosystems show commonly high P use efficiencies but the processes behind this phenomenon are still unresolved. In frame of the priority program "SPP 1685 Ecosystem nutrition - Forest strategies for limited phosphorus resources" around 70 researchers from different disciplines collaborate to unravel these processes. The overall hypothesis to be tested is that the P nutrition strategy of forest ecosystems at sites rich in mineral P is characterized by high P uptake efficiency (acquiring systems). In contrast, the P strategy of forest ecosystems facing low soil P stocks is characterized by highly efficient mechanisms of P recycling. To test this hypothesis, we analyzed five beech forest ecosystems on silicate rock with different parent materials representing a gradient of total P stocks (160 - 900 g P m-2, down to 1m soil depth). In fact, we found evidence confirming our hypothesis, but controls and drivers of P strategies are still unknown as other environmental variables differ. One of those might be the N content, as organisms strive to reach a specific internal N:P ratio. Thus, an additional application of N might also alter P nutrition. To test this, we established a factorial P x N application experiment at three of the study sites. With our presentation we will introduce this experiment and give a review on published P x N experiments discussing different advantages and disadvantages of different basic conditions (e.g. amount and application form, doses, sampling and statistical design, monitoring periods, budget calculation, isotopic tracing). Finally, we want to initiate a common discussion on the standardization of P x N field experiments to enable interdisciplinary and across-compartment comparisons (e.g. different land use, different climate zones, terrestrial and aquatic ecosystems).

The 4d8-(4d74f + 4d76p + 4p54d9) transitions in the spectrum of five times ionized indium (In VI)

NASA Astrophysics Data System (ADS)

Ryabtsev, A. N.; Tauheed, A.; Swapnil; Kildiyarova, R. R.; Kononov, E. Ya

2018-06-01

The spectrum of five times ionized indium excited in a vacuum spark has been studied in the wavelength region 180-250 Å using a 3 m grazing incidence spectrograph. Transitions from highly excited interacting configurations 4d74f + 4d76p + 4p54d9 to the ground state 4d8 configuration were studied. 165 spectral lines were identified and 81 levels of the excited configurations were found.

Capabilities of the Large-Scale Sediment Transport Facility

DTIC Science & Technology

2016-04-01

experiments in wave /current environments. INTRODUCTION: The LSTF (Figure 1) is a large-scale laboratory facility capable of simulating conditions...comparable to low- wave energy coasts. The facility was constructed to address deficiencies in existing methods for calculating longshore sediment...transport. The LSTF consists of a 30 m wide, 50 m long, 1.4 m deep basin. Waves are generated by four digitally controlled wave makers capable of producing

16 CFR Figures 3 and 4 to Part 1204 - High Voltage Test Facility and Antenna System Test Setup

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false High Voltage Test Facility and Antenna System Test Setup 3 Figures 3 and 4 to Part 1204 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... ANTENNAS Pt. 1204, Figs. 3, 4 Figures 3 and 4 to Part 1204—High Voltage Test Facility and Antenna System...

16 CFR Figures 3 and 4 to Part 1204 - High Voltage Test Facility and Antenna System Test Setup

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false High Voltage Test Facility and Antenna System Test Setup 3 Figures 3 and 4 to Part 1204 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... ANTENNAS Pt. 1204, Figs. 3, 4 Figures 3 and 4 to Part 1204—High Voltage Test Facility and Antenna System...

16 CFR Figures 3 and 4 to Part 1204 - High Voltage Test Facility and Antenna System Test Setup

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false High Voltage Test Facility and Antenna System Test Setup 3 Figures 3 and 4 to Part 1204 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... ANTENNAS Pt. 1204, Figs. 3, 4 Figures 3 and 4 to Part 1204—High Voltage Test Facility and Antenna System...

16 CFR Figures 3 and 4 to Part 1204 - High Voltage Test Facility and Antenna System Test Setup

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false High Voltage Test Facility and Antenna System Test Setup 3 Figures 3 and 4 to Part 1204 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... ANTENNAS Pt. 1204, Figs. 3, 4 Figures 3 and 4 to Part 1204—High Voltage Test Facility and Antenna System...

47 CFR 36.157 - Host/remote message Cable and Wire Facilities (C&WF)-Category 4-apportionment procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 2 2011-10-01 2011-10-01 false Host/remote message Cable and Wire Facilities... TELECOMMUNICATIONS COMPANIES 1 Telecommunications Property Cable and Wire Facilities § 36.157 Host/remote message Cable and Wire Facilities (C&WF)—Category 4—apportionment procedures. (a) Host/Remote Message C&WF...

47 CFR 36.157 - Host/remote message Cable and Wire Facilities (C&WF)-Category 4-apportionment procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Host/remote message Cable and Wire Facilities... TELECOMMUNICATIONS COMPANIES 1 Telecommunications Property Cable and Wire Facilities § 36.157 Host/remote message Cable and Wire Facilities (C&WF)—Category 4—apportionment procedures. (a) Host/Remote Message C&WF...

Facile photoreduction of graphene oxide by an NAD(P)H model: Hantzsch 1,4-dihydropyridine.

PubMed

Zhang, Hui-Hui; Liu, Qiang; Feng, Ke; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu

2012-05-29

To make "clean" reduced GO sheets in high quality and in large scale, a natural reduced nicotinamine adenine dinucleotide NAD(P)H model, Hantzsch 1,4-dihydropyridine (HEH), is used as a mild organic photoreductant in this work. Benefiting from the intense absorption of HEH in the range of 300-420 nm, the graphene oxide (GO) can be readily reduced by HEH under UV light irradiation (λ > 320 nm) to afford single or few-layer reduced graphene oxide at room temperature. Studies on reduction extent reveal that both irradiation time and concentration ratio of HEH to GO are important for effective reduction of GO under UV light. The as-prepared photochemically reduced graphene oxide (PRGO) dispersion is stable without the need for any polymeric or surfactant stabilizers. Simply by extraction treatment, the "clean" PRGO sheets can be obtained in large quantities, and its conductivity approaches to 4680 S·m(-1) that is the highest value reported by photochemical approaches so far.

4p16.1-p15.31 duplication and 4p terminal deletion in a 3-years old Chinese girl: Array-CGH, genotype-phenotype and neurological characterization.

PubMed

Piccione, Maria; Salzano, Emanuela; Vecchio, Davide; Ferrara, Dante; Malacarne, Michela; Pierluigi, Mauro; Ferrara, Ines; Corsello, Giovanni

2015-07-01

Microscopically chromosome rearrangements of the short arm of chromosome 4 include the two known clinical entities: partial trisomy 4p and deletions of the Wolf-Hirschhorn critical regions 1 and 2 (WHSCR-1 and WHSCR-2, respectively), which cause cranio-facial anomalies, congenital malformations and developmental delay/intellectual disability. We report on clinical findings detected in a Chinese patient with a de novo 4p16.1-p15.32 duplication in association with a subtle 4p terminal deletion of 6 Mb in size. This unusual chromosome imbalance resulted in WHS classical phenotype, while clinical manifestations of 4p trisomy were practically absent. This observation suggests the hypothesis that haploinsufficiency of sensitive dosage genes with regulatory function placed in WHS critical region, is more pathogenic than concomitant 4p duplicated segment. Additionally clinical findings in our patient confirm a variable penetrance of major malformations and neurological features in Chinese children despite of WHS critical region's deletion. Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Airglow at 630 and 557.7 nm during HF pumping of the Ionosphere near the 4th Gyroharmonic at the ``Sura'' Facility in September 2012

NASA Astrophysics Data System (ADS)

Shindin, Alexey; Nasyrov, Igor; Grach, Savely; Sergeev, Evgeny; Klimenko, Vladimir; Beletsky, Alexandr

, but never observed at the Sura facility for vertical pumping. The data of KEO Sentinel camera obtained on Sep. 11 have shown the suppression of the background existed even for vertical direction while the pump beam was South-inclined by 12° and the spot of enhanced airglow was observed, similar to [2], in the magnetic zenith. Note that earlier experiments near 4fce performed at EISCAT facility during previous Solar maximum did not show any clear dependence of the red and green line brightness of the relation between f0 and 4fce [3]. 1. Layser T.B. // Space Sci. Rev., V. 98, 223 (2001). 2. Grach S.M., et al. // Radiophys. Quantum Electron. V. 55, P. 33-50 (2012). 3. Gustavsson B., et al. // Phys. Rev. Lett., 97, 195002 (2006).

Benchmark experiments at ASTRA facility on definition of space distribution of {sup 235}U fission reaction rate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bobrov, A. A.; Boyarinov, V. F.; Glushkov, A. E.

2012-07-01

Results of critical experiments performed at five ASTRA facility configurations modeling the high-temperature helium-cooled graphite-moderated reactors are presented. Results of experiments on definition of space distribution of {sup 235}U fission reaction rate performed at four from these five configurations are presented more detail. Analysis of available information showed that all experiments on criticality at these five configurations are acceptable for use them as critical benchmark experiments. All experiments on definition of space distribution of {sup 235}U fission reaction rate are acceptable for use them as physical benchmark experiments. (authors)

Does identity shape leadership and management practice? Experiences of PHC facility managers in Cape Town, South Africa

PubMed Central

Daire, Judith; Gilson, Lucy

2014-01-01

In South Africa, as elsewhere, Primary Health Care (PHC) facilities are managed by professional nurses. Little is known about the dimensions and challenges of their job, or what influences their managerial practice. Drawing on leadership and organizational theory, this study explored what the job of being a PHC manager entails, and what factors influence their managerial practice. We specifically considered whether the appointment of professional nurses as facility managers leads to an identity transition, from nurse to manager. The overall intention was to generate ideas about how to support leadership development among PHC facility managers. Adopting case study methodology, the primary researcher facilitated in-depth discussions (about their personal history and managerial experiences) with eight participating facility managers from one geographical area. Other data were collected through in-depth interviews with key informants, document review and researcher field notes/journaling. Analysis involved data triangulation, respondent and peer review and cross-case analysis. The experiences show that the PHC facility manager’s job is dominated by a range of tasks and procedures focused on clinical service management, but is expected to encompass action to address the population and public health needs of the surrounding community. Managing with and through others, and in a complex system, requiring self-management, are critical aspects of the job. A range of personal, professional and contextual factors influence managerial practice, including professional identity. The current largely facility-focused management practice reflects the strong nursing identity of managers and broader organizational influences. However, three of the eight managers appear to self-identify an emerging leadership identity and demonstrate related managerial practices. Nonetheless, there is currently limited support for an identity transition towards leadership in this context. Better

P4 Medicine versus Hippocrates.

PubMed

Pulciani, Simonetta; Di Lonardo, Anna; Fagnani, Corrado; Taruscio, Domenica

2017-01-01

Hippocrates was the first to raise awareness of medicine as a science. He asserted the body being a unified whole and emphasized the importance of preventive and predictive medicine, spurring physicians to foster patient collaboration. Recent achievements today have permitted a new approach "P4 medicine" - Predictive, Preventive, Personalized and Participatory - with the aim of depicting an individual's health history and molecular profile in determining the best medical intervention in maintaining or restoring wellbeing. There is a link, which brings together Hippocrates and P4 Medicine. This review will elaborate further this statement, considering the scientific achievements that paved the way for recent medical approaches. Emphasis will be given to the social impact of new diagnostic and therapeutic protocols, considering their costs and their success probabilities.

Novel fluorescent labelled affinity probes for diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A)-binding studies.

PubMed

Wright, Michael; Miller, Andrew D

2006-02-15

Tandem synthetic-biosynthetic procedures were used to prepare two novel fluorescent labelled affinity probes for diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A)-binding studies. These compounds (dial-mant-Ap4A and azido-mant-Ap4A) are shown to clearly distinguish known Ap4A-binding proteins from Escherichia coli (LysU and GroEL) and a variety of other control proteins. Successful labelling of chaperonin GroEL appears to be allosteric with respect to the well-characterized adenosine 5'-triphosphate (ATP)-binding site, suggesting that GroEL possesses a distinct Ap4A-binding site.

Binding behaviors of p-sulfonatocalix[4]arene with gemini guests.

PubMed

Zhao, Hong-Xia; Guo, Dong-Sheng; Liu, Yu

2013-02-14

A dozen of homoditopic cations, possessing different spacer lengths and rigidities, as well as sizes, shapes, and charges of terminal groups, were synthesized as candidate gemini guests for the complexation of p-sulfonatocalix[4]arenes (SC4A). The 12 gemini guests are divided into five species according to the different terminal groups: imidazolium (G1-G3), pyridinium (G4-G6), quinolinium (G7), viologen (G8-G11), and 1,4-diazabicyclo[2.2.2]octane (DBO, G12). Their binding structures and stoichiometries with SC4A were examined by NMR spectroscopy, which is helpful to construct diverse highly ordered assemblies. The obtained results show that the length of the linkers, as well as the charge numbers on the end groups have a pronounced effect on the binding stoichiometry, whereas the size and shape of the terminal groups have no significant influence. Furthermore, both the stability constants and thermodynamic parameters of SC4A with the terminal subunits were determined by the isothermal titration calorimetry experiments, which are valuable to understand the binding behavior, giving quantitatively deep insight.

Recent Upgrades at the Safety and Tritium Applied Research Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cadwallader, Lee Charles; Merrill, Brad Johnson; Stewart, Dean Andrew

This paper gives a brief overview of the Safety and Tritium Applied Research (STAR) facility operated by the Fusion Safety Program (FSP) at the Idaho National Laboratory (INL). FSP researchers use the STAR facility to carry out experiments in tritium permeation and retention in various fusion materials, including wall armor tile materials. FSP researchers also perform other experimentation as well to support safety assessment in fusion development. This lab, in its present two-building configuration, has been in operation for over ten years. The main experiments at STAR are briefly described. This paper discusses recent work to enhance personnel safety atmore » the facility. The STAR facility is a Department of Energy less than hazard category 3 facility; the personnel safety approach calls for ventilation and tritium monitoring for radiation protection. The tritium areas of STAR have about 4 to 12 air changes per hour, with air flow being once through and then routed to the facility vent stack. Additional radiation monitoring has been installed to read the laboratory room air where experiments with tritium are conducted. These ion chambers and bubblers are used to verify that no significant tritium concentrations are present in the experiment rooms. Standby electrical power has been added to the facility exhaust blower so that proper ventilation will now operate during commercial power outages as well as the real-time tritium air monitors.« less

Geant4 simulation of the CERN-EU high-energy reference field (CERF) facility.

PubMed

Prokopovich, D A; Reinhard, M I; Cornelius, I M; Rosenfeld, A B

2010-09-01

The CERN-EU high-energy reference field facility is used for testing and calibrating both active and passive radiation dosemeters for radiation protection applications in space and aviation. Through a combination of a primary particle beam, target and a suitable designed shielding configuration, the facility is able to reproduce the neutron component of the high altitude radiation field relevant to the jet aviation industry. Simulations of the facility using the GEANT4 (GEometry ANd Tracking) toolkit provide an improved understanding of the neutron particle fluence as well as the particle fluence of other radiation components present. The secondary particle fluence as a function of the primary particle fluence incident on the target and the associated dose equivalent rates were determined at the 20 designated irradiation positions available at the facility. Comparisons of the simulated results with previously published simulations obtained using the FLUKA Monte Carlo code, as well as with experimental results of the neutron fluence obtained with a Bonner sphere spectrometer, are made.

Merging P4P and disease management: how do you know which one is working?

PubMed

Smith, Allen L

2007-03-01

An intervention movement in managed care, disease management (DM), is a system of coordinated health care interventions and communication for populations with conditions in which patient self-care efforts are significant. Another managed care intervention movement, pay for performance (P4P), involves an incentive component in which payment is defined based on meeting specific, previously agreed-upon process or outcomes targets. To explore the various characteristics of DM and P4P interventions, determine how they differ, and explore the differences in results of programs in current practice. In DM, regular ongoing evaluation of clinical, humanistic, and economic outcomes plays a crucial role in reducing costs and improving quality of care. The goal of improving overall patient health in DM is also accomplished by supporting the physician or practitioner/patient relationship and plan of care. P4P initiatives vary more according to the needs and preferences of local providers and plans than do DM initiatives. While DM programs can be implemented without necessarily changing how providers deliver health care, P4P requires new programs and/or systems within the provider sector to improve patient care quality and/or efficiency. P4P initiatives also typically involve the upside or downside risk by physicians/hospitals. Partners HealthCare, based in Boston, features P4P initiatives for inpatient admissions, diabetes, and radiology that have all been met with success. Both DM and P4P initiatives have been successful in managed care. However, in terms of determining whether DM or P4P initiatives are more effective in improving the quality and efficiency of health care delivery, it is simply too early to tell at this time.

Two U.S. Experiments to Fly Aboard European Spacelab Facility in 1996

NASA Technical Reports Server (NTRS)

1996-01-01

Space provides researchers a way to study the behavior of fluids when the forces of gravity are removed. The studies described here involve international cooperative research projects to study various aspects of fluid behavior in a microgravity environment. These projects utilize the Bubble Droplet Particle Unit (BDPU), which was built by the European Space Agency's (ESA) Technology Center in Noordwijk, The Netherlands. This Spacelab-based multiuser facility flew for the first time in July 1994 on the second International Microgravity Laboratory (IML-2). It is scheduled for reflight on the Life and Microgravity Sciences (LMS) mission in June 1996. This experiment hardware was designed primarily to conduct fluid physics experiments with transparent fluids. LMS will fly both European and U.S. investigations including experiments defined by Professor R.S. Subramanian of Clarkson University in Potsdam, New York, and Professor S.A. Saville of Princeton University, Princeton, New Jersey.

Development of a polar direct drive platform for mix and burn experiments on the National Ignition Facility

NASA Astrophysics Data System (ADS)

Murphy, T. J.; Kyrala, G. A.; Krasheninnikova, N. S.; Bradley, P. A.; Cobble, J. A.; Tregillis, I. L.; Obrey, K. A. D.; Baumgaertel, J. A.; Hsu, S. C.; Shah, R. C.; Hakel, P.; Kline, J. L.; Schmitt, M. J.; Kanzleiter, R. J.; Batha, S. H.; Wallace, R. J.; Bhandarkar, S.; Fitzsimmons, P.; Hoppe, M.; Nikroo, A.; McKenty, P.

2016-03-01

Capsules driven with polar drive [1, 2] on the National Ignition Facility [3] are being used [4] to study mix in convergent geometry. In preparation for experiments that will utilize deuterated plastic shells with a pure tritium fill, hydrogen-filled capsules with copper- doped deuterated layers have been imploded on NIF to provide spectroscopic and nuclear measurements of capsule performance. Experiments have shown that the mix region, when composed of shell material doped with about 1% copper (by atom), reaches temperatures of about 2 keV, while undoped mixed regions reach about 3 keV. Based on the yield from these implosions, we estimate the thickness of CD that mixed into the gas as between about 0.25 and 0.43 μm of the inner capsule surface, corresponding to about 5 to 9 μg of material. Using 5 atm of tritium as the fill gas should result in over 1013 DT neutrons being produced, which is sufficient for neutron imaging [5].

Molecular modeling of cytochrome P450 3A4

NASA Astrophysics Data System (ADS)

Szklarz, Grazyna D.; Halpert, James R.

1997-05-01

The three-dimensional structure of human cytochrome P450 3A4 was modeled based on crystallographic coordinates of four bacterial P450s: P450 BM-3, P450cam, P450terp, and P450eryF. The P450 3A4 sequence was aligned to those of the known proteins using a structure-based alignment of P450 BM-3, P450cam, P450terp, and P450eryF. The coordinates of the model were then calculated using a consensus strategy, and the final structure was optimized in the presence of water. The P450 3A4 model resembles P450 BM-3 the most, but the B' helix is similar to that of P450eryF, which leads to an enlarged active site when compared with P450 BM-3, P450cam, and P450terp. The 3A4 residues equivalent to known substrate contact residues of the bacterial proteins and key residues of rat P450 2B1 are located in the active site or the substrate access channel. Docking of progesterone into the P450 3A4 model demonstrated that the substrate bound in a 6β-orientation can interact with a number of active site residues, such as 114, 119, 301, 304, 305, 309, 370, 373, and 479, through hydrophobic interactions. The active site of the enzyme can also accommodate erythromycin, which, in addition to the residues listed for progesterone, also contacts residues 101, 104, 105, 214, 215, 217, 218, 374, and 478. The majority of 3A4 residues which interact with progesterone and/or erythromycin possess their equivalents in key residues of P450 2B enzymes, except for residues 297, 480 and 482, which do not contact either substrate in P450 3A4. The results from docking of progesterone and erythromycin into the enzyme model make it possible to pinpoint residues which may be important for 3A4 function and to target them for site-directed mutagenesis.

STAR - Research Experiences at National Laboratory Facilities for Pre-Service and Early Career Teachers

NASA Astrophysics Data System (ADS)

Keller, J. M.; Rebar, B.; Buxner, S.

2012-12-01

The STEM Teacher and Researcher (STAR) Program provides pre-service and beginning teachers the opportunity to develop identity as both teachers and researchers early in their careers. Founded and implemented by the Center for Excellence in Science and Mathematics Education (CESaME) at California Polytechnic State University on behalf of the California State University (CSU) system, STAR provides cutting edge research experiences and career development for students affiliated with the CSU system. Over the past three summers, STAR has also partnered with the NSF Robert Noyce Teacher Scholarship Program to include Noyce Scholars from across the country. Key experiences are one to three summers of paid research experience at federal research facilities associated with the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), National Oceanic and Atmospheric Association (NOAA), and the National Optical Astronomy Observatory (NOAO). Anchoring beginning teachers in the research community enhances participant understanding of what it means to be both researchers and effective teachers. Since its inception in 2007, the STAR Program has partnered with 15 national lab facilities to provide 290 research experiences to 230 participants. Several of the 68 STAR Fellows participating in the program during Summer 2012 have submitted abstracts to the Fall AGU Meeting. Through continued partnership with the Noyce Scholar Program and contributions from outside funding sources, the CSU is committed to sustaining the STAR Program in its efforts to significantly impact teacher preparation. Evaluation results from the program continue to indicate program effectiveness in recruiting high quality science and math majors into the teaching profession and impacting their attitudes and beliefs towards the nature of science and teaching through inquiry. Additionally, surveys and interviews are being conducted of participants who are now teaching in the classroom as

Clinical manifestations of trisomy 4p syndrome.

PubMed

Patel, S V; Dagnew, H; Parekh, A J; Koenig, E; Conte, R A; Macera, M J; Verma, R S

1995-06-01

Trisomy 4p syndrome is a distinct clinical entity which was noted almost a quarter century ago by Wilson et al. [71] and later was delineated by Gonzalez and colleagues [29]. The variation in the length of duplicated segment usually associated with monosomy of other genetic material which has resulted in confusion and as a result a so-called 4p syndrome could not be recognized without cytogenetic analysis. We wish to draw the attention of clinicians to this subject by presenting the description of over 75 cases including one from our clinic and stress the point that molecular approaches are imperative to characterize this anomaly. After extensive review, it appears that patients retaining at least the distal two-thirds to the entire short arm share an overlapping phenotypic expression that constitutes pure trisomy 4p syndrome which includes prominent glabella, bulbous nose with flat or depressed nasal bridge, retrognathia, pointed chin, short neck with low hairline, enlarged ears with abnormal helix and antihelix, rocker-bottom feet with prominent heel. Arachnodactyly and camptodactyly. Molecular characterization of 4p is imperative. We have also included an extensive bibliography for clinicians who may find it useful as a single reference source for evaluating their future cases. The 4p-syndrome is a distinct entity but without cytogenetic evaluation, the syndrome can not be recognized.

A facile one-pot preparation of Co3O4/g-C3N4 heterojunctions with excellent electrocatalytic activity for the detection of environmental phenolic hormones

NASA Astrophysics Data System (ADS)

Sun, Yanjuan; Jiang, Jizhou; Liu, Yi; Wu, Shengli; Zou, Jing

2018-02-01

The Co3O4/g-C3N4 heterojunctions were prepared by a facile one-pot thermal decomposition technique. Compared with g-C3N4, it was found that Co3O4/g-C3N4 heterojunctions possessed a higher Brunner-Emmet-Teller (BET) surface area, which was beneficial to the diffusion of aim molecules on the electrode surfaces. And the optimal Co3O4/g-C3N4 heterojunctions exhibited a narrower band gap and a higher donor density, resulting in an excellent electrocatalytic activity for environmental phenolic hormones. Moreover, the Co3O4/g-C3N4 heterojunctions were used for the electrochemical sensing of environmental phenolic hormones such as bisphenol A, pentachlorophenol, p-nitrophenol and octylphenol. All detection ranges reached three orders of magnitude, showing a lower limit of detection of 10-9 mol L-1. So, sensitivity and accurate determination of environmental phenolic hormones in real water samples may use this Co3O4/g-C3N4 heterojunctions modified electrode.

Ion channel regulation by phosphoinositides analyzed with VSPs—PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility

PubMed Central

Rjasanow, Alexandra; Leitner, Michael G.; Thallmair, Veronika; Halaszovich, Christian R.; Oliver, Dominik

2015-01-01

The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P2 are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5)P2. Yet, measuring affinities for endogenous PIs has not been possible directly, but has relied largely on the response to soluble analogs, which may not quantitatively reflect binding to native lipids. Voltage-sensitive phosphatases (VSPs) turn over PI(4,5)P2 to PI(4)P when activated by depolarization. In combination with voltage-clamp electrophysiology VSPs are useful tools for rapid and reversible depletion of PI(4,5)P2. Because cellular PI(4,5)P2 is resynthesized rapidly, steady state PI(4,5)P2 changes with the degree of VSP activation and thus depends on membrane potential. Here we show that titration of endogenous PI(4,5)P2 with Ci-VSP allows for the quantification of relative PI(4,5)P2 affinities of ion channels. The sensitivity of inward rectifier and voltage-gated K+ channels to Ci-VSP allowed for comparison of PI(4,5)P2 affinities within and across channel subfamilies and detected changes of affinity in mutant channels. The results also reveal that VSPs are useful only for PI effectors with high binding specificity among PI isoforms, because PI(4,5)P2 depletion occurs at constant overall PI level. Thus, Kir6.2, a channel activated by PI(4,5)P2 and PI(4)P was insensitive to VSP. Surprisingly, despite comparable PI(4,5)P2 affinity as determined by Ci-VSP, the Kv7 and Kir channel families strongly differed in their sensitivity to receptor-mediated depletion of PI(4,5)P2. While Kv7 members were highly sensitive to activation of PLC by Gq-coupled receptors, Kir channels were insensitive even when PI(4,5)P2 affinity was lowered by mutation. We hypothesize that different channels may be associated with distinct pools of PI(4,5)P2 that differ in their accessibility to PLC and VSPs. PMID

Initial design for an experimental investigation of strongly coupled plasma behavior in the Atlas facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munson, C.P.; Benage, J.F. Jr.; Taylor, A.J.

Atlas is a high current ({approximately} 30 MA peak, with a current risetime {approximately} 4.5 {micro}sec), high energy (E{sub stored} = 24 MJ, E{sub load} = 3--6 MJ), pulsed power facility which is being constructed at Los Alamos National Laboratory with a scheduled completion date in the year 2000. When operational, this facility will provide a platform for experiments in high pressure shocks (> 20 Mbar), adiabatic compression ({rho}/{rho}{sub 0} > 5, P > 10 Mbar), high magnetic fields ({approximately} 2,000 T), high strain and strain rates ({var_epsilon} > 200%, d{var_epsilon}/dt {approximately} 10{sup 4} to 10{sup 6} s{sup {minus}1}), hydrodynamicmore » instabilities of materials in turbulent regimes, magnetized target fusion, equation of state, and strongly coupled plasmas. For the strongly coupled plasma experiments, an auxiliary capacitor bank will be used to generate a moderate density (< 0.1 solid), relatively cold ({approximately} 1 eV) plasma by ohmic heating of a conducting material of interest such as titanium. This stargate plasma will be compressed against a central column containing diagnostic instrumentation by a cylindrical conducting liner that is driven radially inward by current from the main Atlas capacitor bank. The plasma is predicted to reach densities of {approximately} 1.1 times solid, achieve ion and electron temperatures of {approximately} 10 eV, and pressures of {approximately} 4--5 Mbar. This is a density/temperature regime which is expected to experience strong coupling, but only partial degeneracy. X-ray radiography is planned for measurements of the material density at discrete times during the experiments; diamond Raman measurements are anticipated for determination of the pressure. In addition, a neutron resonance spectroscopic technique is being evaluated for possible determination of the temperature (through low percentage doping of the titanium with a suitable resonant material). Initial target plasma formation experiments

SANE's Measurement of the Proton's Virtual Photon Spin Asymmetry, A p 1, at Large Bjorken x

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mulholland, Jonathan

2012-05-01

The experiment SANE (Spin Asymmetries of the Nucleon Experiment) measured inclusive double polarization electron asymmetries on a proton target at the Continuous Electron Beam Accelerator Facility at the Thomas Jefferson National Laboratory in Newport News Virgina. Polarized electrons were scattered from a solid 14NH 3 polarized target provided by the University of Virginia target group. Measurements were taken with the target polarization oriented at 80 degrees and 180 degrees relative to the beam direction, and beam energies of 4.7 and 5.9 GeV were used. Scattered electrons were detected by a multi-component novel non-magnetic detector package constructed for this experiment. Asymmetriesmore » measured at the two target orientations allow for the extraction of the virtual Compton asymmetries A 1 p and A 2 p as well as the spin structure functions g 1 p and g 2 p. This work addresses the extraction of the virtual Compton asymmetry A 1 p in the deep inelastic regime. The analysis uses data in the kinematic range from Bjorken x of 0.30 to 0.55, separated into four Q 2 bins from 1.9 to 4.7 GeV 2.« less

Facilities, breed and experience affect ease of sheep handling: the livestock transporter's perspective.

PubMed

Burnard, C L; Pitchford, W S; Hocking Edwards, J E; Hazel, S J

2015-08-01

An understanding of the perceived importance of a variety of factors affecting the ease of handling of sheep and the interactions between these factors is valuable in improving profitability and welfare of the livestock. Many factors may contribute to animal behaviour during handling, and traditionally these factors have been assessed in isolation under experimental conditions. A human social component to this phenomenon also exists. The aim of this study was to gain a deeper understanding of the importance of a variety of factors affecting ease of handling, and the interactions between these from the perspective of the livestock transporter. Qualitative interviews were used to investigate the factors affecting sheep behaviour during handling. Interview transcripts underwent thematic analysis. Livestock transporters discussed the effects of attitudes and behaviours towards sheep, helpers, facilities, distractions, environment, dogs and a variety of sheep factors including breed, preparation, experience and sex on sheep behaviour during handling. Transporters demonstrated care and empathy and stated that patience and experience were key factors determining how a person might deal with difficult sheep. Livestock transporters strongly believed facilities (ramps and yards) had the greatest impact, followed by sheep experience (naivety of the sheep to handling and transport) and breed. Transporters also discussed the effects of distractions, time of day, weather, dogs, other people, sheep preparation, body condition and sheep sex on ease of handling. The concept of individual sheep temperament was indirectly expressed.

Establishing a cGMP pancreatic islet processing facility: the first experience in Iran.

PubMed

Larijani, Bagher; Arjmand, Babak; Amoli, Mahsa M; Ao, Ziliang; Jafarian, Ali; Mahdavi-Mazdah, Mitra; Ghanaati, Hossein; Baradar-Jalili, Reza; Sharghi, Sasan; Norouzi-Javidan, Abbas; Aghayan, Hamid Reza

2012-12-01

It has been predicted that one of the greatest increase in prevalence of diabetes will happen in the Middle East bear in the next decades. The aim of standard therapeutic strategies for diabetes is better control of complications. In contrast, some new strategies like cell and gene therapy have aimed to cure the disease. In recent years, significant progress has occurred in beta-cell replacement therapies with a progressive improvement of short-term and long term outcomes. In year 2005, considering the impact of the disease in Iran and the promising results of the Edmonton protocol, the funding for establishing a current Good Manufacturing Practice (cGMP) islet processing facility by Endocrinology and Metabolism Research Center was approved by Tehran University of Medical Sciences. Several islet isolations were performed following establishment of cGMP facility and recruitment of all required equipments for process validation and experimental purpose. Finally the first successful clinical islet isolation and transplantation was performed in September 2010. In spite of a high cost of the procedure it is considered beneficial and may prevent long term complications and the costs associated with secondary cares. In this article we will briefly describe our experience in setting up a cGMP islet processing facility which can provide valuable information for regional countries interested to establish similar facilities.

Conceptual Design of Tail-Research EXperiment (T-REX) on Space Plasma Environment Research Facility

NASA Astrophysics Data System (ADS)

Xiao, Qingmei; Wang, Xiaogang; E, Peng; Shen, Chao; Wang, Zhibin; Mao, Aohua; Xiao, Chijie; Ding, Weixing; Ji, Hantao; Ren, Yang

2016-10-01

Space Environment Simulation Research Infrastructure (SESRI), a scientific project for a major national facility of fundamental researches, has recently been launched at Harbin Institute of Technology (HIT). The Space Plasma Environment Research Facility (SPERF) for simulation of space plasma environment is one of the components of SESRI. It is designed to investigate fundamental issues in space plasma environment, such as energetic particles transportation and the interaction with waves in magnetosphere, magnetic reconnection at magnetopause and magnetotail, etc. Tail-Research Experiment (T-REX) is part of the SPERF for laboratory studies of space physics relevant to tail reconnection and dipolarization process. T-REX is designed to carry out two kinds of experiments: the tail plasmamoid for magnetic reconnection and magnetohydrodynamic waves excited by high speed plasma jet. In this presentation, the scientific goals and experimental plans for T-REX together with the means applied to generate the plasma with desired parameters are reviewed. Two typical scenarios of T-REX with operations of plasma sources and various magnetic configurations to study specific physical processes in space plasmas will also be presented.

MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4

PubMed Central

Zhang, Kundong; Cen, Gang; Jiang, Tao; Cao, Jun; Huang, Kejian; Zhao, Qian; Qiu, Zhengjun

2015-01-01

Background Aim to determine the clinicopathological and prognostic role of miR-301a-3p in pancreatic ductal adenocarcinoma(PDAC), to investigate the biological mechanism of miR-301a-3p in vitro and in vivo. Methods By tissue microarray analysis, we studied miR-301a-3p expression in PDAC patients and its clinicopathological correlations as well as prognostic significance. qRT-PCR was used to test miR-301a-3p expression in PDAC tissues and cell lines. Functional experiments including in vitro and in vivo were performed. Results Significantly higher expression of miR-301a-3p were found in PDAC patients with lymph node metastasis and advanced pathological stages and identified as an independent prognostic factor for worse survival. In PDAC samples and cell lines, miR-301a-3p was significantly up-regulated compared with matched non-tumor tissues and normal pancreatic ductal cells, respectively. Overexpression of miR-301a-3p enhanced PDAC cells colony, invasion and migration abilities in vitro as well as tumorigenicity in vivo. Furthermore, SMAD4 was identified as a target gene of miR-301a-3p by cell as well as mice xenograft experiments. In PDAC tissue microarray, a significantly inverse correlation between miR-301a-3p ISH scores and SMAD4 IHC scores were observed in both tumor and corresponding non-tumor tissues. Conclusion MiR-301a-3p functions as a novel oncogene in PDAC and the oncogenic activity may involve its inhibition of the target gene SMAD4. PMID:26019136

Validation of the 4P's Plus screen for substance use in pregnancy validation of the 4P's Plus.

PubMed

Chasnoff, I J; Wells, A M; McGourty, R F; Bailey, L K

2007-12-01

The purpose of this study is to validate the 4P's Plus screen for substance use in pregnancy. A total of 228 pregnant women enrolled in prenatal care underwent screening with the 4P's Plus and received a follow-up clinical assessment for substance use. Statistical analyses regarding reliability, sensitivity, specificity, and positive and negative predictive validity of the 4Ps Plus were conducted. The overall reliability for the five-item measure was 0.62. Seventy-four (32.5%) of the women had a positive screen. Sensitivity and specificity were very good, at 87 and 76%, respectively. Positive predictive validity was low (36%), but negative predictive validity was quite high (97%). Of the 31 women who had a positive clinical assessment, 45% were using less than 1 day per week. The 4P's Plus reliably and effectively screens pregnant women for risk of substance use, including those women typically missed by other perinatal screening methodologies.

Effects of N and P fertilisation on greenhouse gas (GHG) production in floodplain fen peat: A microcosm fertilisation experiment.

NASA Astrophysics Data System (ADS)

Stanley, Kieran; Heppell, Catherine; Belyea, Lisa; Baird, Andrew

2016-04-01

Biogeochemical and hydrological cycles are being significantly perturbed by anthropic activities altering atmospheric mole fractions of greenhouse gases (GHG) and increasing global temperatures. With the intensification of the hydrological cycle, lowland areas, such as floodplain fens, may be inundated more frequently. Rivers in agricultural catchments have the potential to pollute floodplain fens with significant amounts of nitrogen (N) and phosphorus (P); however, the effects of short-term (< 15 days) N and P fertilisation via fluvial inundation on GHG emissions from floodplain fens are poorly understood. The aim of this research was to determine how N (51 mg L-1 NO3-N) and P (1.4 mg L-1 PO43--P) additions may alter GHG (CO2, CH4, and N2O) production in floodplain fens of contrasting nutrient status under anaerobic conditions. A five-level (control, glucose (G), N+G, P+G, and N+P+G), fully-factorial microcosm experiment was designed and undertaken in Spring 2013 with peat from two floodplain fens under conservation management with similar vegetation (from Norfolk, United Kingdom). One site receives a higher nutrient load than the other and has a historical legacy of higher N and P contents within the peat. Results from the experiment showed no significant difference in CO2 production between the control and fertilised treatments from 0 to 96 hours, but a significant difference between treatments (ANCOVA, between factors: treatment and site; covariate: time; F4,419 = 11.844, p < 0.001) and site (F1,149 = 5.721, p = 0.017) from 96 hours to in the end of the experiment due to fermentation. N2O production only occurred in samples fertilised with N (N+G and N+P+G) due to denitrification. Rates of N2O production were significantly greater in samples from the lower-nutrient site in comparison to the nutrient-rich site (t12= 6.539, p < 0.001 and t12= 7.273, p < 0.001 for N+G and N+P+G fertilised samples, respectively). Fertilisation with N and P had different effects on

Search for Hidden Particles (SHiP): a new experiment proposal

NASA Astrophysics Data System (ADS)

De Lellis, G.

2015-06-01

Searches for new physics with accelerators are being performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. We propose a new experimental facility meant to search for very weakly coupled particles in the few GeV mass domain. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored from the experimental point of view. A beam dump facility, built at CERN in the north area, using 400 GeV protons is a copious factory of charmed hadrons and could be used to probe the existence of such particles. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. In particular, tau anti-neutrinos have not been observed so far. We therefore propose an experiment to search for hidden particles and study tau neutrino physics at the same time.

Critical experiments at Sandia National Laboratories : technical meeting on low-power critical facilities and small reactors.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harms, Gary A.; Ford, John T.; Barber, Allison Delo

2010-11-01

Sandia National Laboratories (SNL) has conducted radiation effects testing for the Department of Energy (DOE) and other contractors supporting the DOE since the 1960's. Over this period, the research reactor facilities at Sandia have had a primary mission to provide appropriate nuclear radiation environments for radiation testing and qualification of electronic components and other devices. The current generation of reactors includes the Annular Core Research Reactor (ACRR), a water-moderated pool-type reactor, fueled by elements constructed from UO2-BeO ceramic fuel pellets, and the Sandia Pulse Reactor III (SPR-III), a bare metal fast burst reactor utilizing a uranium-molybdenum alloy fuel. The SPR-IIImore » is currently defueled. The SPR Facility (SPRF) has hosted a series of critical experiments. A purpose-built critical experiment was first operated at the SPRF in the late 1980's. This experiment, called the Space Nuclear Thermal Propulsion Critical Experiment (CX), was designed to explore the reactor physics of a nuclear thermal rocket motor. This experiment was fueled with highly-enriched uranium carbide fuel in annular water-moderated fuel elements. The experiment program was completed and the fuel for the experiment was moved off-site. A second critical experiment, the Burnup Credit Critical Experiment (BUCCX) was operated at Sandia in 2002. The critical assembly for this experiment was based on the assembly used in the CX modified to accommodate low-enriched pin-type fuel in water moderator. This experiment was designed as a platform in which the reactivity effects of specific fission product poisons could be measured. Experiments were carried out on rhodium, an important fission product poison. The fuel and assembly hardware for the BUCCX remains at Sandia and is available for future experimentation. The critical experiment currently in operation at the SPRF is the Seven Percent Critical Experiment (7uPCX). This experiment is designed to provide

Photonuclear reactions in astrophysical p-process: Theoretical calculations and experiment simulation based on ELI-NP

NASA Astrophysics Data System (ADS)

Xu, Yi; Luo, Wen; Balabanski, Dimiter; Goriely, Stephane; Matei, Catalin; Tesileanu, Ovidiu

2017-09-01

The astrophysical p-process is an important way of nucleosynthesis to produce the stable and proton-rich nuclei beyond Fe which can not be reached by the s- and r-processes. In the present study, the astrophysical reaction rates of (γ,n), (γ,p), and (γ,α) reactions are computed within the modern reaction code TALYS for about 3000 stable and proton-rich nuclei with 12 < Z < 110. The nuclear structure ingredients involved in the calculation are determined from experimental data whenever available and, if not, from global microscopic nuclear models. In particular, both of the Wood-Saxon potential and the double folding potential with density dependent M3Y (DDM3Y) effective interaction are used for the calculations. It is found that the photonuclear reaction rates are very sensitive to the nuclear potential, and the better determination of nuclear potential would be important to reduce the uncertainties of reaction rates. Meanwhile, the Extreme Light Infrastructure-Nuclear Physics (ELI-NP) facility is being developed, which will provide the great opportunity to experimentally study the photonuclear reactions in p-process. Simulations of the experimental setup for the measurements of the photonuclear reactions 96Ru(γ,p) and 96Ru(γ,α) are performed. It is shown that the experiments of photonuclear reactions in p-process based on ELI-NP are quite promising.

Operational recovery of turbine No. 3 at Potomac Edison`s Dam No. 4 hydrogenerating facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pelczar, R.S.

1995-12-31

The Potomac Edison Dam No. 4 hydroelectric generating station is a historic, turn of the century facility located on the Potomac River near Shepherdstown, West Virginia. The station, originally constructed in 1909, employed twin horizontal Francis hydroturbine generating systems. The systems are unique in that the turbines and generators are offset 37 feet, interconnected by rope and sheaves. In May 1989 a third vertical open flume turbine generating system was added to make use of available site capacity. Both the turbine and speed increaser were the largest products developed by their respective manufacturers for a hydro turbine-generator application. This papermore » will review the subsequent operational experience which led to the original speed increaser failure on unit No. 3 and replacement of the drive system including special design considerations to the replacement speed increaser and its support structure. Specific design challenges included: (1) Designing and implementing a reliable configuration. (2) Reducing operational sound levels. (3) Minimizing harmful structure-borne vibrations which were affecting the internal rotating elements. (4) Incorporating a system brake for emergency and service purposes.« less

Report on Beryllium Strength Experiments Conducted at the TA-55 40 mm Impact Test Facility, Fiscal Year 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, William Wyatt; Hollowell, Benjamin Charles; Martinez, Todd P.

A series of experiments is currently in progress at eth 40 mm Impact Test Facility (ITF), located at TA-55, to understand the strength behavior of Beryllium metal at elevated temperature and pressure. In FY 2017, three experiments were conducted as a part of this project.

The Underground Laboratory in South Korea : facilities and experiments

NASA Astrophysics Data System (ADS)

Kim, Yeongduk

2017-01-01

We have developed underground physics programs for last 15 years in South Korea. The scientific and technical motivation for this initiative was the lack of local facility of a large accelerator in Korea. Thanks to the large underground electric power generator in Yangyang area, we could construct a deep underground laboratory (Yangyang Laboratory, Y2L) and has performed some pioneering experiments for dark matter search and double beta decay experiments. Since year of 2013, a new research center in the Institute for Basic Science (IBS), Center for Underground Physics (CUP), is approved by the government and Y2L laboratory is managed by CUP. Due to the limited space in Y2L, we are proposing to construct a new deep underground laboratory where we can host larger scale experiments of next generation. The site is in an active iron mine, and will be made in 1100 meter underground with a space of about 2000 m2 by the end of 2019. I will describe the status and future plan for this underground laboratory. CUP has two main experimental programs. (1) Identification of dark matter : The annual modulation signal of DAMA/LIBRA experiment has been contradictory to many other experiments such as XENON100, LUX, and Super CDMS. Yale University and CUP (COSINE-100) experimentalists agreed to do an experiment together at the Y2L and recently commissioned a 100kg scale low background NaI(Tl) crystal experiment. In future, we will develop NaI(Tl) crystals with lower internal backgrounds and try to run identical detectors at both north and south hemisphere. Low mass WIMP search is also planned with a development of low temperature sensors coupled with highly scintillating crystals. (2) Neutrinoless double beta decay search : The mass of the lightest neutrino and the Majorana nature of the neutrinos are not determined yet. Neutrinoless double beta decay experiment can answer both of the questions directly, and ultra-low backgrounds and excellent energy resolution are critical to

GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion.

PubMed

Wang, Hanzhi; Sun, Hui-Qiao; Zhu, Xiaohui; Zhang, Li; Albanesi, Joseph; Levine, Beth; Yin, Helen

2015-06-02

The Atg8 autophagy proteins are essential for autophagosome biogenesis and maturation. The γ-aminobutyric acid receptor-associated protein (GABARAP) Atg8 family is much less understood than the LC3 Atg8 family, and the relationship between the GABARAPs' previously identified roles as modulators of transmembrane protein trafficking and autophagy is not known. Here we report that GABARAPs recruit palmitoylated PI4KIIα, a lipid kinase that generates phosphatidylinositol 4-phosphate (PI4P) and binds GABARAPs, from the perinuclear Golgi region to autophagosomes to generate PI4P in situ. Depletion of either GABARAP or PI4KIIα, or overexpression of a dominant-negative kinase-dead PI4KIIα mutant, decreases autophagy flux by blocking autophagsome:lysosome fusion, resulting in the accumulation of abnormally large autophagosomes. The autophagosome defects are rescued by overexpressing PI4KIIα or by restoring intracellular PI4P through "PI4P shuttling." Importantly, PI4KIIα's role in autophagy is distinct from that of PI4KIIIβ and is independent of subsequent phosphatidylinositol 4,5 biphosphate (PIP2) generation. Thus, GABARAPs recruit PI4KIIα to autophagosomes, and PI4P generation on autophagosomes is critically important for fusion with lysosomes. Our results establish that PI4KIIα and PI4P are essential effectors of the GABARAP interactome's fusion machinery.

Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography.

PubMed

Elmaleh, D R; Fischman, A J; Tawakol, A; Zhu, A; Shoup, T M; Hoffmann, U; Brownell, A-L; Zamecnik, P C

2006-10-24

Diadenosine-5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) and its analog P(2),P(3)-monochloromethylene diadenosine-5',5'''-P(1),P(4)-tetraphosphate (AppCHClppA) are competitive inhibitors of adenosine diphosphate-induced platelet aggregation, which plays a central role in arterial thrombosis and plaque formation. In this study, we evaluate the imaging capabilities of positron-emission tomography (PET) with P(2),P(3)-[(18)F]monofluoromethylene diadenosine-5',5'''-P(1),P(4)-tetraphosphate ([(18)F]AppCHFppA) to detect atherosclerotic lesions in male New Zealand White rabbits. Three to six months after balloon injury to the aorta, the rabbits were injected with [(18)F]AppCHFppA, and microPET imaging showed rapid accumulation of this radiopharmaceutical in the atherosclerotic abdominal aorta, with lesions clearly visible 30 min after injection. Computed tomographic images were coregistered with PET images to improve delineation of aortoiliac tracer activity. Plaque macrophage density, quantified by immunostaining with RAM11 against rabbit macrophages, correlated with PET measurements of [(18)F]AppCHFppA uptake (r = 0.87, P < 0.0001), whereas smooth-muscle cell density, quantified by immunostaining with 1A4 against smooth muscle actin, did not. Biodistribution studies of [(18)F]AppCHFppA in normal rats indicated typical adenosine dinucleotide behavior with insignificant myocardial uptake and fast kidney clearance. The accumulation of [(18)F]AppCHFppA in macrophage-rich atherosclerotic plaques can be quantified noninvasively with PET. Hence, [(18)F]AppCHFppA holds promise for the noninvasive characterization of vascular inflammation.

Analysis of the National Ignition Facility Ignition Hohlraum Energetics Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Town, R J; Rosen, M D; Michel, P A

2010-11-22

A series of forty experiments on the National Ignition Facility (NIF) [E. I. Moses et al., Phys. Plasmas 16, 041006 (2009)] to study energy balance and implosion symmetry in reduced- and full-scale ignition hohlraums was shot at energies up to 1.3 MJ. This paper reports the findings of the analysis of the ensemble of experimental data obtained that has produced an improved model for simulating ignition hohlraums. Last year the first observation in a NIF hohlraum of energy transfer between cones of beams as a function of wavelength shift between those cones was reported [P. Michel, et al, Phys ofmore » Plasmas, 17, 056305, (2010)]. Detailed analysis of hohlraum wall emission as measured through the laser entrance hole (LEH) has allowed the amount of energy transferred versus wavelength shift to be quantified. The change in outer beam brightness is found to be quantitatively consistent with LASNEX [G. B. Zimmerman and W. L. Kruer, Comments Plasma Phys. Control. Fusion 2, 51 (1975)] simulations using the predicted energy transfer when possible saturation of the plasma wave mediating the transfer is included. The effect of the predicted energy transfer on implosion symmetry is also found to be in good agreement with gated x-ray framing camera images. Hohlraum energy balance, as measured by x-ray power escaping the LEH, is quantitatively consistent with revised estimates of backscatter and incident laser energy combined with a more rigorous non-local-thermodynamic-equilibrium atomic physics model with greater emissivity than the simpler average-atom model used in the original design of NIF targets.« less

NAIM and site-specific functional group modification analysis of RNase P RNA: magnesium dependent structure within the conserved P1-P4 multihelix junction contributes to catalysis.

PubMed

Kaye, Nicholas M; Christian, Eric L; Harris, Michael E

2002-04-09

The tRNA processing endonuclease ribonuclease P contains an essential and highly conserved RNA molecule (RNase P RNA) that is the catalytic subunit of the enzyme. To identify and characterize functional groups involved in RNase P RNA catalysis, we applied self-cleaving ribozyme-substrate conjugates, on the basis of the RNase P RNA from Escherichia coli, in nucleotide analogue interference mapping (NAIM) and site-specific modification experiments. At high monovalent ion concentrations (3 M) that facilitate protein-independent substrate binding, we find that the ribozyme is largely insensitive to analogue substitution and that concentrations of Mg2+ (1.25 mM) well below that necessary for optimal catalytic rate (>100 mM) are required to produce interference effects because of modification of nucleotide bases. An examination of the pH dependence of the reaction rate at 1.25 mM Mg2+ indicates that the increased sensitivity to analogue interference is not due to a change in the rate-limiting step. The nucleotide positions detected by NAIM under these conditions are located exclusively in the catalytic domain, consistent with the proposed global structure of the ribozyme, and predominantly occur within the highly conserved P1-P4 multihelix junction. Several sensitive positions in J3/4 and J2/4 are proximal to a previously identified site of divalent metal ion binding in the P1-P4 element. Kinetic analysis of ribozymes with site-specific N7-deazaadenosine and deazaguanosine modifications in J3/4 was, in general, consistent with the interference results and also permitted the analysis of sites not accessible by NAIM. These results show that, in this region only, modification of the N7 positions of A62, A65, and A66 resulted in measurable effects on reaction rate and modification at each position displayed distinct sensitivities to Mg2+ concentration. These results reveal a restricted subset of individual functional groups within the catalytic domain that are particularly

Assessing the Impact of Community Engagement Interventions on Health Worker Motivation and Experiences with Clients in Primary Health Facilities in Ghana: A Randomized Cluster Trial

PubMed Central

Alhassan, Robert Kaba; Nketiah-Amponsah, Edward; Spieker, Nicole; Arhinful, Daniel Kojo; Rinke de Wit, Tobias F.

2016-01-01

Background Health worker density per 1000 population in Ghana is one of the lowest in the world estimated to be 2.3, below the global average of 9.3. Low health worker motivation induced by poor working conditions partly explain this challenge. Albeit the wage bill for public sector health workers is about 90% of domestic government expenditure on health in countries such as Ghana, staff motivation and performance output remain a challenge, suggesting the need to complement financial incentives with non-financial incentives through a community-based approach. In this study, a systematic community engagement (SCE) intervention was implemented to engage community groups in healthcare quality assessment to promote mutual collaboration between clients and healthcare providers, and enhance health worker motivation levels. SCE involves structured use of existing community groups and associations to assess healthcare quality in health facilities. Identified quality gaps are discussed with healthcare providers, improvements made and rewards given to best performing facilities for closing quality care gaps. Purpose To evaluate the effect of SCE interventions on health worker motivation and experiences with clients. Methods The study is a cluster randomized trial involving health workers in private (n = 38) and public (n = 26) primary healthcare facilities in two administrative regions in Ghana. Out of 324 clinical and non-clinical staff randomly interviewed at baseline, 234 (72%) were successfully followed at end-line and interviewed on workplace motivation factors and personal experiences with clients. Propensity score matching and difference-in-difference estimations were used to estimate treatment effect of the interventions on staff motivation. Results Intrinsic (non-financial) work incentives including cordiality with clients and perceived career prospects appeared to be prime sources of motivation for health staff interviewed in intervention health facilities while

Assessing the Impact of Community Engagement Interventions on Health Worker Motivation and Experiences with Clients in Primary Health Facilities in Ghana: A Randomized Cluster Trial.

PubMed

Alhassan, Robert Kaba; Nketiah-Amponsah, Edward; Spieker, Nicole; Arhinful, Daniel Kojo; Rinke de Wit, Tobias F

2016-01-01

Health worker density per 1000 population in Ghana is one of the lowest in the world estimated to be 2.3, below the global average of 9.3. Low health worker motivation induced by poor working conditions partly explain this challenge. Albeit the wage bill for public sector health workers is about 90% of domestic government expenditure on health in countries such as Ghana, staff motivation and performance output remain a challenge, suggesting the need to complement financial incentives with non-financial incentives through a community-based approach. In this study, a systematic community engagement (SCE) intervention was implemented to engage community groups in healthcare quality assessment to promote mutual collaboration between clients and healthcare providers, and enhance health worker motivation levels. SCE involves structured use of existing community groups and associations to assess healthcare quality in health facilities. Identified quality gaps are discussed with healthcare providers, improvements made and rewards given to best performing facilities for closing quality care gaps. To evaluate the effect of SCE interventions on health worker motivation and experiences with clients. The study is a cluster randomized trial involving health workers in private (n = 38) and public (n = 26) primary healthcare facilities in two administrative regions in Ghana. Out of 324 clinical and non-clinical staff randomly interviewed at baseline, 234 (72%) were successfully followed at end-line and interviewed on workplace motivation factors and personal experiences with clients. Propensity score matching and difference-in-difference estimations were used to estimate treatment effect of the interventions on staff motivation. Intrinsic (non-financial) work incentives including cordiality with clients and perceived career prospects appeared to be prime sources of motivation for health staff interviewed in intervention health facilities while financial incentives were ranked

[Recombinant chromosome 4 with partial 4p deletion and 4q duplication inherited from paternal pericentric inversion].

PubMed

Mun, Se Jin; Cho, Eun Hae; Chey, Myoung-Jae; Shim, Gyu-Hong; Shin, Bo-Moon; Lee, Rae-Kyung; Ko, Ji-Kyung; Yoo, Soo Jin

2010-02-01

Pericentric inversion of chromosome 4 can give rise to 2 alternate recombinant (rec) chromosomesby duplication or deletion of 4p. The deletion of distal 4p manifests as Wolf-Hirschhorn syndrome (WHS). Here, we report the molecular cytogenetic findings and clinical manifestations observed in an infant with 46,XX,rec(4)dup(4q)inv(4)(p16q31.3)pat. The infant was delivered by Cesarean section at the 33rd week of gestation because pleural effusion and polyhydramnios were detected on ultrasonography. At birth, the infant showed no malformation or dysfunction, except for a preauricular skin tag. Array comparative genomic hybridization analysis of neonatal peripheral blood samples showed a gain of 38 Mb on 4q31.3-qter and a loss of 3 Mb on 4p16.3, and these results were consistent with WHS. At the last follow-up at 8 months of age (corrected age, 6 months), the infant had not achieved complete head control.

Hydrodynamic instability experiments with three-dimensional modulations at the National Ignition Facility

DOE PAGES

Smalyuk, V. A.; Weber, S. V.; Casey, D. T.; ...

2015-06-18

The first hydrodynamic instability growth measurements with three-dimensional (3D) surface-roughness modulations were performed on CH shell spherical implosions at the National Ignition Facility (NIF) [G. H. Miller, E. I. Moses, and C. R. Wuest, Opt. Eng. 43, 2841 (2004)]. The initial capsule outer-surface amplitudes were increased approximately four times, compared with the standard specifications, to increase the signal-to-noise ratio, helping to qualify a technique for measuring small 3D modulations. The instability growth measurements were performed using x-ray through-foil radiography based on time-resolved pinhole imaging. Averaging over 15 similar images significantly increased the signal-to-noise ratio, making possible a comparison with 3Dmore » simulations. At a convergence ratio of ~2.4, the measured modulation levels were ~3 times larger than those simulated based on the growth of the known imposed initial surface modulations. Several hypotheses are discussed, including increased instability growth due to modulations of the oxygen content in the bulk of the capsule. In conclusion, future experiments will be focused on measurements with standard 3D ‘native-roughness’ capsules as well as with deliberately imposed oxygen modulations.« less

Transitioning from caregiver to visitor in a long-term care facility: the experience of caregivers of people with dementia.

PubMed

Crawford, K; Digby, R; Bloomer, M; Tan, H; Williams, A

2015-01-01

Transitioning from the primary caregiver to the visitor in a long-term care facility may be challenging for the caregiver; they are required to surrender their caring duties to the medical and nursing staff. The aim of this study was to explore the experiences of caregivers during their transition from day-to-day caregiver of a person with dementia to a visitor in a long-term care facility. This study utilised a qualitative descriptive design. Twenty caregivers of people with dementia were recruited from the one Aged Rehabilitation and Geriatric Evaluation and Management facility, located in Victoria, Australia. Semi-structured interviews were used to explore the caregiver's experiences. Interviews were analysed using thematic analysis. The interview data revealed that the participants were undergoing similar experiences. The findings revealed that it was difficult for the caregiver to transition to their new role of visitor; negative reactions of grief, loss of motivation and loneliness were also coupled with positive feelings of relief and the reassurance that their relative or friend would be well cared for and safe within the long-term care facility. The findings offer insight into the experiences felt by caregivers when their relative or friend with dementia is admitted to hospital. Implications of this study include the need to improve the transition process for the caregiver by allowing them to be involved in the decision-making process, keeping them informed of care decisions, and importantly, providing emotional support to help the caregiver positively adapt to this transition.

A discrete choice experiment to determine facility-based delivery services desired by women and men in rural Ethiopia

PubMed Central

Beam, Nancy K; Bekele Dadi, Gezehegn; Rankin, Sally H; Weiss, Sandra; Cooper, Bruce; Thompson, Lisa M

2018-01-01

Objectives Despite global efforts to increase facility-based delivery (FBD), 90% of women in rural Ethiopia deliver at home without a skilled birth attendant. Men have an important role in increasing FBD due to their decision-making power, but this is largely unexplored. This study aimed to determine the FBD care attributes preferred by women and men, and whether poverty or household decision-making are associated with choice to deliver in a facility. Setting and participants We conducted a cross-sectional discrete choice experiment in 109 randomly selected households in rural Ethiopia in September–October 2015. We interviewed women who were pregnant or who had a child <2 years old and their male partners. Results Both women and men preferred health facilities where medications and supplies were available (OR=3.08; 95% CI 2.03 to 4.67 and OR=2.68; 95% CI 1.79 to 4.02, respectively), a support person was allowed in the delivery room (OR=1.69; 95% CI 1.37 to 2.07 and OR=1.74; 95% CI 1.42 to 2.14, respectively) and delivery cost was low (OR=1.15 95% CI 1.12 to 1.18 and OR=1.14; 95% CI 1.11 to 1.17, respectively). Women valued free ambulance service (OR=1.37; 95% CI 1.09 to 1.70), while men favoured nearby facilities (OR=1.09; 95% CI 1.06 to 1.13) with friendly providers (OR=1.30; 95% CI 1.03 to 1.64). Provider preferences were complex. Neither women nor men preferred female doctors to health extension workers (HEW) (OR=0.92; 95% CI 0.59 to 1.42 and OR=0.74; 95% CI 0.47 to 1.14, respectively), male doctors to HEW (OR=1.33; 95% CI 0.89 to 1.99 and OR=0.75; 95% CI 0.50 to 1.12, respectively) or female over male nurses (OR=0.68; 95% CI 0.94 to 1.71 and OR=1.03; 95% CI 0.77 to 2.94, respectively). While both women and men preferred male nurses to HEW (OR=1.86; 95% CI 1.23 to 2.80 and OR=1.95; 95% CI 1.30 to 2.95, respectively), men (OR=1.89; 95% CI 1.29 to 2.78), but not women (OR=1.47; 95% CI 1.00 to 2.13) preferred HEW to female

Health facilities safety in natural disasters: experiences and challenges from South East Europe.

PubMed

Radovic, Vesela; Vitale, Ksenija; Tchounwou, Paul B

2012-05-01

The United Nations named 2010 as a year of natural disasters, and launched a worldwide campaign to improve the safety of schools and hospitals from natural disasters. In the region of South East Europe, Croatia and Serbia have suffered the greatest impacts of natural disasters on their communities and health facilities. In this paper the disaster management approaches of the two countries are compared, with a special emphasis on the existing technological and legislative systems for safety and protection of health facilities and people. Strategic measures that should be taken in future to provide better safety for health facilities and populations, based on the best practices and positive experiences in other countries are recommended. Due to the expected consequences of global climate change in the region and the increased different environmental risks both countries need to refine their disaster preparedness strategies. Also, in the South East Europe, the effects of a natural disaster are amplified in the health sector due to its critical medical infrastructure. Therefore, the principles of environmental security should be implemented in public health policies in the described region, along with principles of disaster management through regional collaborations.

Skylab experiments. Volume 4: Life sciences