Sample records for facility interim safety

  1. 75 FR 45678 - Notice of Availability of Interim Staff Guidance Document for Fuel Cycle Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... Document for Fuel Cycle Facilities AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability..., Division of Fuel Cycle Safety and Safeguards, Office of Nuclear Material Safety and Safeguards, U.S... Commission (NRC) prepares and issues Interim Staff Guidance (ISG) documents for fuel cycle facilities. These...

  2. Medicare and Medicaid programs; fire safety requirements for certain health care facilities; amendment. Interim final rule with comment period.

    PubMed

    2005-03-25

    This interim final rule with comment period adopts the substance of the April 15, 2004 temporary interim amendment (TIA) 00-1 (101), Alcohol Based Hand Rub Solutions, an amendment to the 2000 edition of the Life Safety Code, published by the National Fire Protection Association (NFPA). This amendment will allow certain health care facilities to place alcohol-based hand rub dispensers in egress corridors under specified conditions. This interim final rule with comment period also requires that nursing facilities install smoke detectors in resident rooms and public areas if they do not have a sprinkler system installed throughout the facility or a hard-wired smoke detection system in those areas.

  3. Medicare and Medicaid programs; fire safety requirements for certain health care facilities; amendment. Final rule.

    PubMed

    2006-09-22

    This final rule adopts the substance of the April 15, 2004 tentative interim amendment (TIA) 00-1 (101), Alcohol Based Hand Rub Solutions, an amendment to the 2000 edition of the Life Safety Code, published by the National Fire Protection Association (NFPA). This amendment allows certain health care facilities to place alcohol-based hand rub dispensers in egress corridors under specified conditions. This final rule also requires that nursing facilities at least install battery-operated single station smoke alarms in resident rooms and common areas if they are not fully sprinklered or they do not have system-based smoke detectors in those areas. Finally, this final rule confirms as final the provisions of the March 25, 2005 interim final rule with changes and responds to public comments on that rule.

  4. Plutonium storage criteria

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chung, D.; Ascanio, X.

    1996-05-01

    The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less thanmore » 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.« less

  5. Progress on plutonium stabilization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hurt, D.

    1996-05-01

    The Defense Nuclear Facilities Safety Board has safety oversight responsibility for most of the facilities where unstable forms of plutonium are being processed and packaged for interim storage. The Board has issued recommendations on plutonium stabilization and has has a considerable influence on DOE`s stabilization schedules and priorities. The Board has not made any recommendations on long-term plutonium disposition, although it may get more involved in the future if DOE develops plans to use defense nuclear facilities for disposition activities.

  6. German Support Program for Retrieval and Safe Storage of Disused Radioactive Sealed Sources in Ukraine - 13194

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pretzsch, Gunter; Salewski, Peter; Sogalla, Martin

    2013-07-01

    The German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) on behalf of the Government of the Federal Republic of Germany supports the State Nuclear Regulatory Inspectorate of Ukraine (SNRIU) in enhancement of nuclear safety and radiation protection and strengthening of the physical protection. One of the main objectives of the agreement concluded by these parties in 2008 was the retrieval and safe interim storage of disused orphan high radioactive sealed sources in Ukraine. At present, the Ukrainian National Registry does not account all high active radiation sources but only for about 70 - 80 %. GRSmore » in charge of BMU to execute the program since 2008 concluded subcontracts with the waste management and interim storage facilities RADON at different regions in Ukraine as well with the waste management and interim storage facility IZOTOP at Kiev. Below selected examples of removal of high active Co-60 and Cs-137 sources from irradiation facilities at research institutes are described. By end of 2012 removal and safe interim storage of 12.000 disused radioactive sealed sources with a total activity of more than 5,7.10{sup 14} Bq was achieved within the frame of this program. The German support program will be continued up to the end of 2013 with the aim to remove and safely store almost all disused radioactive sealed sources in Ukraine. (authors)« less

  7. A security vulnerabilities assessment tool for interim storage facilities of low-level radioactive wastes.

    PubMed

    Bible, J; Emery, R J; Williams, T; Wang, S

    2006-11-01

    Limited permanent low-level radioactive waste (LLRW) disposal capacity and correspondingly high disposal costs have resulted in the creation of numerous interim storage facilities for either decay-in-storage operations or longer term accumulation efforts. These facilities, which may be near the site of waste generation or in distal locations, often were not originally designed for the purpose of LLRW storage, particularly with regard to security. Facility security has become particularly important in light of the domestic terrorist acts of 2001, wherein LLRW, along with many other sources of radioactivity, became recognized commodities to those wishing to create disruption through the purposeful dissemination of radioactive materials. Since some LLRW materials may be in facilities that may exhibit varying degrees of security control sophistication, a security vulnerabilities assessment tool grounded in accepted criminal justice theory and security practice has been developed. The tool, which includes dedicated sections on general security, target hardening, criminalization benefits, and the presence of guardians, can be used by those not formally schooled in the security profession to assess the level of protection afforded to their respective facilities. The tool equips radiation safety practitioners with the ability to methodically and systematically assess the presence or relative status of various facility security aspects, many of which may not be considered by individuals from outside the security profession. For example, radiation safety professionals might not ordinarily consider facility lighting aspects, which is a staple for the security profession since it is widely known that crime disproportionately occurs more frequently at night or in poorly lit circumstances. Likewise, the means and associated time dimensions for detecting inventory discrepancies may not be commonly considered. The tool provides a simple means for radiation safety professionals to assess, and perhaps enhance in a reasonable fashion, the security of their interim storage operations. Aspects of the assessment tool can also be applied to other activities involving the protection of sources of radiation as well.

  8. Nuclear criticality safety evaluation of the passage of decontaminated salt solution from the ITP filters into tank 50H for interim storage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hobbs, D.T.; Davis, J.R.

    This report assesses the nuclear criticality safety associated with the decontaminated salt solution after passing through the In-Tank Precipitation (ITP) filters, through the stripper columns and into Tank 50H for interim storage until transfer to the Saltstone facility. The criticality safety basis for the ITP process is documented. Criticality safety in the ITP filtrate has been analyzed under normal and process upset conditions. This report evaluates the potential for criticality due to the precipitation or crystallization of fissionable material from solution and an ITP process filter failure in which insoluble material carryover from salt dissolution is present. It is concludedmore » that no single inadvertent error will cause criticality and that the process will remain subcritical under normal and credible abnormal conditions.« less

  9. 76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Adult Detention Facility Guidelines AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice. SUMMARY: This notice announces the online publication of the Interim BIA Adult Detention Facility Guidelines and... Indian Affairs Web site. DATES: These Interim BIA Adult Detention Facility Guidelines and Interim Model...

  10. Multi Canister Overpack (MCO) Topical Report [SEC 1 THRU 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LORENZ, B.D.

    In February 1995, the US Department of Energy (DOE) approved the Spent Nuclear Fuel (SNF) Project's ''Path Forward'' recommendation for resolution of the safety and environmental concerns associated with the deteriorating SNF stored in the Hanford Site's K Basins (Hansen 1995). The recommendation included an aggressive series of projects to design, construct, and operate systems and facilitates to permit the safe retrieval, packaging, transport, conditions, and interim storage of the K Basins' SNF. The facilities are the Cold VAcuum Drying Facility (CVDF) in the 100 K Area of the Hanford Site and the Canister Storage building (CSB) in the 200more » East Area. The K Basins' SNF is to be cleaned, repackaged in multi-canister overpacks (MCOs), removed from the K Basins, and transported to the CVDF for initial drying. The MCOs would then be moved to the CSB and weld sealed (Loscoe 1996) for interim storage (about 40 years). One of the major tasks associated with the initial Path Forward activities is the development and maintenance of the safety documentation. In addition to meeting the construction needs for new structures, the safety documentation for each must be generated.« less

  11. Training forensic staff.

    PubMed

    Hall-McGee, P

    1997-01-01

    The author provides a training package for forensic staff on how to handle prisoner patients who are being treated at a healthcare facility. She covers such topics as fire and evacuation plans, interim life safety measures, blood and bloodborne pathogens exposure, universal precautions, respiratory protection and TB, and voluntary medical immobilization and protection devices.

  12. The Homestake Interim Laboratory and Homestake DUSEL

    NASA Astrophysics Data System (ADS)

    Lesko, Kevin T.

    2011-12-01

    The former Homestake gold mine in Lead South Dakota is proposed for the National Science Foundation's Deep Underground Science and Engineering Laboratory (DUSEL). The gold mine provides expedient access to depths in excess of 8000 feet below the surface (>7000 mwe). Homestake's long history of promoting scientific endeavours includes the Davis Solar Neutrino Experiment, a chlorine-based experiment that was hosted at the 4850 Level for more than 30 years. As DUSEL, Homestake would be uncompromised by competition with mining interests or other shared uses. The facility's 600-km of drifts would be available for conversion for scientific and educational uses. The State of South Dakota, under Governor Rounds' leadership, has demonstrated exceptionally strong support for Homestake and the creation of DUSEL. The State has provided funding totalling $46M for the preservation of the site for DUSEL and for the conversion and operation of the Homestake Interim Laboratory. Motivated by the strong educational and outreach potential of Homestake, the State contracted a Conversion Plan by world-recognized mine-engineering contractor to define the process of rehabilitating the facility, establishing the appropriate safety program, and regaining access to the facility. The State of South Dakota has established the South Dakota Science and Technology Authority to oversee the transfer of the Homestake property to the State and the rehabilitation and preservation of the facility. The Homestake Scientific Collaboration and the State of South Dakota's Science and Technology Authority has called for Letters of Interest from scientific, educational and engineering collaborations and institutions that are interested in hosting experiments and uses in the Homestake Interim Facility in advance of the NSF's DUSEL, to define experiments starting as early as 2007. The Homestake Program Advisory Committee has reviewed these Letters and their initial report has been released. Options for developing the Homestake Interim Laboratory and evolving this facility into DUSEL are presented.

  13. Flight set 360L007 (STS-33) insulation component. Volume 3: Final release

    NASA Technical Reports Server (NTRS)

    Hicken, Steve

    1990-01-01

    Volume 3 of this postfire report deals with the insulation component of the RSRM. The report is released twice for each flight set. The interim release contract date is on or before 60 days after the last field joint or nozzle to case joint is disassembled at KSC and contain the results of the KSC visual evaluation. The data contained in Volume 3 interim release supersedes the insulation data presented in the KSC 10 day report. The final release contract data is on or before 60 days after the last factory joint is disassembled at the Clearfield H-7 facility and contains the results of all visual evaluations and a thermal safety factor analysis. The data contained in the Volume 3 final release supersedes the interim release and the insulation data presented in the Clearfield 10 day report.

  14. Ageing management program for the Spanish low and intermediate level waste disposal and spent fuel and high-level waste centralised storage facilities

    NASA Astrophysics Data System (ADS)

    Zuloaga, P.; Ordoñez, M.; Andrade, C.; Castellote, M.

    2011-04-01

    The generic design of the centralised spent fuel storage facility was approved by the Spanish Safety Authority in 2006. The planned operational life is 60 years, while the design service life is 100 years. Durability studies and surveillance of the behaviour have been considered from the initial design steps, taking into account the accessibility limitations and temperatures involved. The paper presents an overview of the ageing management program set in support of the Performance Assessment and Safety Review of El Cabril low and intermediate level waste (LILW) disposal facility. Based on the experience gained for LILW, ENRESA has developed a preliminary definition of the Ageing Management Plan for the Centralised Interim Storage Facility of spent Fuel and High Level Waste (HLW), which addresses the behaviour of spent fuel, its retrievability, the confinement system and the reinforced concrete structure. It includes tests plans and surveillance design considerations, based on the El Cabril LILW disposal facility.

  15. Radioactive Wastes.

    PubMed

    Choudri, B S; Charabi, Yassine; Baawain, Mahad; Ahmed, Mushtaque

    2017-10-01

    Papers reviewed herein present a general overview of radioactive waste related activities around the world in 2016. The current reveiw include studies related to safety assessments, decommission and decontamination of nuclear facilities, fusion facilities, transportation. Further, the review highlights on management solutions for the final disposal of low and high level radioactive wastes (LLW and HLW), interim storage and final disposal options for spent fuel (SF), and tritiated wastes, with a focus on environmental impacts due to the mobility of radionuclides in ecosystem, water and soil alongwith other progress made in the management of radioactive wastes.

  16. 33 CFR 96.360 - Interim Safety Management Certificate: what is it and when can it be used?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section, when— (1) The company's valid Document of Compliance certificate or Interim Document of Compliance certificate applies to that vessel type; (2) The company's safety management system for the vessel... to the responsible person or their company. (b) An Interim Safety Management Certificate is valid for...

  17. Basis for Interim Operation for Fuel Supply Shutdown Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    BENECKE, M.W.

    2003-02-03

    This document establishes the Basis for Interim Operation (BIO) for the Fuel Supply Shutdown Facility (FSS) as managed by the 300 Area Deactivation Project (300 ADP) organization in accordance with the requirements of the Project Hanford Management Contract procedure (PHMC) HNF-PRO-700, ''Safety Analysis and Technical Safety Requirements''. A hazard classification (Benecke 2003a) has been prepared for the facility in accordance with DOE-STD-1027-92 resulting in the assignment of Hazard Category 3 for FSS Facility buildings that store N Reactor fuel materials (303-B, 3712, and 3716). All others are designated Industrial buildings. It is concluded that the risks associated with the currentmore » and planned operational mode of the FSS Facility (uranium storage, uranium repackaging and shipment, cleanup, and transition activities, etc.) are acceptable. The potential radiological dose and toxicological consequences for a range of credible uranium storage building have been analyzed using Hanford accepted methods. Risk Class designations are summarized for representative events in Table 1.6-1. Mitigation was not considered for any event except the random fire event that exceeds predicted consequences based on existing source and combustible loading because of an inadvertent increase in combustible loading. For that event, a housekeeping program to manage transient combustibles is credited to reduce the probability. An additional administrative control is established to protect assumptions regarding source term by limiting inventories of fuel and combustible materials. Another is established to maintain the criticality safety program. Additional defense-in-depth controls are established to perform fire protection system testing, inspection, and maintenance to ensure predicted availability of those systems, and to maintain the radiological control program. It is also concluded that because an accidental nuclear criticality is not credible based on the low uranium enrichment, the form of the uranium, and the required controls, a Criticality Alarm System (CAS) is not required as allowed by DOE Order 420.1 (DOE 2000).« less

  18. How the University of Texas system responded to the need for interim storage of low-level radioactive waste materials.

    PubMed

    Emery, Robert J

    2012-11-01

    Faced with the prospect of being unable to permanently dispose of low-level radioactive wastes (LLRW) generated from teaching, research, and patient care activities, component institutions of the University of Texas System worked collaboratively to create a dedicated interim storage facility to be used until a permanent disposal facility became available. Located in a remote section of West Texas, the University of Texas System Interim Storage Facility (UTSISF) was licensed and put into operation in 1993, and since then has provided safe and secure interim storage for up to 350 drums of dry solid LLRW at any given time. Interim storage capability provided needed relief to component institutions, whose on-site waste facilities could have possibly become overburdened. Experiences gained from the licensing and operation of the site are described, and as a new permanent LLRW disposal facility emerges in Texas, a potential new role for the storage facility as a surge capacity storage site in times of natural disasters and emergencies is also discussed.

  19. Environmental Survey preliminary report, Pantex Facility, Amarillo, Texas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Pantex Facility, conducted November 3 through 14, 1986.The Survey is being conducted by an interdisciplinary team of environmental specialist, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. Individual team components are outside experts being supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with the Pantex Facility. The Survey covers all environmental media and all areas of environmental regulation.more » It is being performed in accordance with the DOE Environmental Survey Manual. The on-site phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at the Pantex Facility, and interviews with site personnel. The Survey team developed a Sampling and Analysis Plan to assist in further assessing certain of the environmental problems identified during its on-site activities. The Sampling and Analysis Plan will be executed by the Oak Ridge National Laboratory. When completed, the results will be incorporated into the Pantex Facility Environmental Survey Interim Report. The Interim Report will reflect the final determinations of the Survey for the Pantex Facility. 65 refs., 44 figs., 27 tabs.« less

  20. Lessons learned from the Siting Process of an Interim Storage Facility in Spain - 12024

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lamolla, Meritxell Martell

    2012-07-01

    On 29 December 2009, the Spanish government launched a site selection process to host a centralised interim storage facility for spent fuel and high-level radioactive waste. It was an unprecedented call for voluntarism among Spanish municipalities to site a controversial facility. Two nuclear municipalities, amongst a total of thirteen municipalities from five different regions, presented their candidatures to host the facility in their territories. For two years the government did not make a decision. Only in November 30, 2011, the new government elected on 20 November 2011 officially selected a non-nuclear municipality, Villar de Canas, for hosting this facility. Thismore » paper focuses on analysing the factors facilitating and hindering the siting of controversial facilities, in particular the interim storage facility in Spain. It demonstrates that involving all stakeholders in the decision-making process should not be underestimated. In the case of Spain, all regional governments where there were candidate municipalities willing to host the centralised interim storage facility, publicly opposed to the siting of the facility. (author)« less

  1. Hydrazine Blending and Storage Facility, Interim Response Action Implementation. Final Safety Plan

    DTIC Science & Technology

    1989-08-30

    operators and visitors, will be required to wear a personal hydrazine dosimeter at all times. These will be available from commercial sources and/or the Naval...suspectea or carcinogenic pocen:tal for =an. -- t, :t ha a,,-cn OSL ?:L. Is I pPm or 1.3 mg/m 3 . zo pp=n4p"NIOSI. (1978) hs a oe -nded a ceiling level

  2. Implementation of EPA criminal enforcement strategy for RCRA interim status facilities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1985-11-15

    The directive discusses criminal enforcement priorities and procedures related to the RCRA section 3007(e)(2) Loss of Interim Status (LOIS) provision, including: (1) identifying/targeting facilities with violations, (2) verifying receipt of RCRA 3007 letters, and (3) inspections of facilities. The directive supplements directive no. 9930.0-1 RCRA LOIS Enforcement Strategy, dated October 15, 1985. The directive is supplemented by directive no. 9930.0-2a, Accepting Nonhazardous Waste After Losing Interim Status, dated December 20, 1986.

  3. 78 FR 72897 - Draft Guidance for Industry on Interim Product Reporting for Human Drug Compounding Outsourcing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-04

    ...] Draft Guidance for Industry on Interim Product Reporting for Human Drug Compounding Outsourcing... Compounding Outsourcing Facilities Under Section 503B of the Federal Food, Drug, and Cosmetic Act.'' The draft... human drug compounders that choose to register as outsourcing facilities (outsourcing facilities). DATES...

  4. 42 CFR 413.350 - Periodic interim payments for skilled nursing facilities receiving payment under the skilled...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Periodic interim payments for skilled nursing facilities receiving payment under the skilled nursing facility prospective payment system for Part A...-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING...

  5. 42 CFR 413.350 - Periodic interim payments for skilled nursing facilities receiving payment under the skilled...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Periodic interim payments for skilled nursing facilities receiving payment under the skilled nursing facility prospective payment system for Part A...-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING...

  6. 42 CFR 413.350 - Periodic interim payments for skilled nursing facilities receiving payment under the skilled...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Periodic interim payments for skilled nursing facilities receiving payment under the skilled nursing facility prospective payment system for Part A...-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING...

  7. 42 CFR 413.350 - Periodic interim payments for skilled nursing facilities receiving payment under the skilled...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Periodic interim payments for skilled nursing facilities receiving payment under the skilled nursing facility prospective payment system for Part A...-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING...

  8. 42 CFR 413.350 - Periodic interim payments for skilled nursing facilities receiving payment under the skilled...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Periodic interim payments for skilled nursing facilities receiving payment under the skilled nursing facility prospective payment system for Part A...-STAGE RENAL DISEASE SERVICES; OPTIONAL PROSPECTIVELY DETERMINED PAYMENT RATES FOR SKILLED NURSING...

  9. 16 CFR 1209.1 - Scope and application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM... part 1209, an interim consumer product safety standard, prescribes flame resistance and corrosiveness requirements for cellulose insulation that is a consumer product. These requirements are intended to reduce or...

  10. 16 CFR 1209.1 - Scope and application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM... part 1209, an interim consumer product safety standard, prescribes flame resistance and corrosiveness requirements for cellulose insulation that is a consumer product. These requirements are intended to reduce or...

  11. 16 CFR 1209.1 - Scope and application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM... part 1209, an interim consumer product safety standard, prescribes flame resistance and corrosiveness requirements for cellulose insulation that is a consumer product. These requirements are intended to reduce or...

  12. Integrated waste management system costs in a MPC system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Supko, E.M.

    1995-12-01

    The impact on system costs of including a centralized interim storage facility as part of an integrated waste management system based on multi-purpose canister (MPC) technology was assessed in analyses by Energy Resources International, Inc. A system cost savings of $1 to $2 billion occurs if the Department of Energy begins spent fuel acceptance in 1998 at a centralized interim storage facility. That is, the savings associated with decreased utility spent fuel management costs will be greater than the cost of constructing and operating a centralized interim storage facility.

  13. Evaluation of US 119 Pine Mountain safety improvements : interim report.

    DOT National Transportation Integrated Search

    2003-10-01

    The safety improvement project for a section of US 119 across Pine Mountain in Letcher County was initiated as an interim effort to address safety issues related t o roadway geometrics and specific problems related to truck traffic. : Specific object...

  14. 16 CFR 1209.31 - Purpose and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1209.31 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.31 Purpose and applicability. (a..., importers, and private labelers must follow to certify that their products comply with the Amended Interim...

  15. The Creation of a French Basic Nuclear Installation - Description of the Regulatory Process - 13293

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mahe, Carole; Leroy, Christine

    CEA is a French government-funded technological research organization. It has to build a medium-level waste interim storage facility because the geological repository will not be available until 2025. This interim storage facility, called DIADEM, has to be available in 2017. These wastes are coming from the research facilities for spent fuel reprocessing and the dismantling of the most radioactive parts of nuclear facilities. The CEA handles the waste management by inventorying the needs and updating them regularly. The conception of the facility is mainly based on this inventory. It provides quantity and characteristics of wastes and it gives the productionmore » schedule until 2035. Beyond mass and volume, main characteristics of these radioactive wastes are chemical nature, radioisotopes, radioactivity, radiation dose, the heat emitted, corrosive or explosive gas production, etc. These characteristics provide information to study the repository safety. DIADEM mainly consists of a concrete cell, isolated from the outside, wherein stainless steel welded containers are stored, stacked in a vertical position in the racks. DIADEM is scheduled to store three types of 8 mm-thick, stainless steel cylindrical containers with an outside diameter 498 mm and height from 620 to 2120 mm. DIADEM will be a basic nuclear installation (INB in French) because of overall activity of radioactive substances stored. The creation of a French basic nuclear installation is subject to authorization according to the French law No. 2006-686 of 13 June 2006 on Transparency and Security in the Nuclear Field. The authorization takes into account the technical and financial capacities of the licensee which must allow him to conduct his project in compliance with these interests, especially to cover the costs of decommissioning the installation and conduct remediation work, and to monitor and maintain its location site or, for radioactive waste disposal installations, to cover the definitive shut-down, maintenance and surveillance expenditure. The authorization is issued by a decree adopted upon advice of the French Nuclear Safety Authority and after a public enquiry. In accordance with Decree No. 2007-1557 of November 2, 2007, the application is filed with the ministries responsible for nuclear safety and the Nuclear Safety Authority. It consists of twelve files and four records information. The favorable opinion of the Nuclear Safety Authority on the folder is required to start the public inquiry. Once the public inquiry is completed, the building permit is issued by the prefect. (authors)« less

  16. The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study.

    PubMed

    Holubkov, Richard; Casper, T Charles; Dean, J Michael; Anand, K J S; Zimmerman, Jerry; Meert, Kathleen L; Newth, Christopher J L; Berger, John; Harrison, Rick; Willson, Douglas F; Nicholson, Carol

    2013-05-01

    Randomized clinical trials are commonly overseen by a Data and Safety Monitoring Board comprised of experts in medicine, ethics, and biostatistics. Data and Safety Monitoring Board responsibilities include protocol approval, interim review of study enrollment, protocol compliance, safety, and efficacy data. Data and Safety Monitoring Board decisions can affect study design and conduct, as well as reported findings. Researchers must incorporate Data and Safety Monitoring Board oversight into the design, monitoring, and reporting of randomized trials. Case study, narrative review. The Data and Safety Monitoring Board's role during the comparative pediatric Critical Illness Stress-Induced Immune Suppression (CRISIS) Prevention Trial is described. The National Institutes of Health-appointed CRISIS Data and Safety Monitoring Board was charged with monitoring sample size adequacy and feasibility, safety with respect to adverse events and 28-day mortality, and efficacy with respect to the primary nosocomial infection/sepsis outcome. The Federal Drug Administration also requested Data and Safety Monitoring Board interim review before opening CRISIS to children below 1 yr of age. The first interim analysis found higher 28-day mortality in one treatment arm. The Data and Safety Monitoring Board maintained trial closure to younger children and requested a second interim data review 6 months later. At this second meeting, mortality was no longer of concern, whereas a weak efficacy trend of lower infection/sepsis rates in one study arm emerged. As over 40% of total patients had been enrolled, the Data and Safety Monitoring Board elected to examine conditional power and unmask treatment arm identities. On finding somewhat greater efficacy in the placebo arm, the Data and Safety Monitoring Board recommended stopping CRISIS due to futility. The design and operating procedures of a multicenter randomized trial must consider a pivotal Data and Safety Monitoring Board role. Maximum study design flexibility must be allowed, and investigators must be prepared for protocol modifications due to interim findings. The Data and Safety Monitoring Board must have sufficient clinical and statistical expertise to assess potential importance of interim treatment differences in the setting of multiple looks at accumulating data with numerous outcomes and subgroups.

  17. Accounting for interim safety monitoring of an adverse event upon termination of a clinical trial.

    PubMed

    Dallas, Michael J

    2008-01-01

    Upon termination of a clinical trial that uses interim evaluations to determine whether the trial can be stopped, a proper statistical analysis must account for the interim evaluations. For example, in a group-sequential design where the efficacy of a treatment regimen is evaluated at interim stages, and the opportunity to stop the trial based on positive efficacy findings exists, the terminal p-value, point estimate, and confidence limits of the outcome of interest must be adjusted to eliminate bias. While it is standard practice to adjust terminal statistical analyses due to opportunities to stop for "positive" findings, adjusting due to opportunities to stop for "negative" findings is also important. Stopping rules for negative findings are particularly useful when monitoring a specific rare serious adverse event in trials designed to show safety with respect to the event. In these settings, establishing conservative stopping rules are appropriate, and therefore accounting for the interim monitoring can have a substantial effect on the final results. Here I present a method to account for interim safety monitoring and illustrate its usefulness. The method is demonstrated to have advantages over methodology that does not account for interim monitoring.

  18. Conceptual design statement of work for the immobilized low-activity waste interim storage facility project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carlson, T.A., Fluor Daniel Hanford

    1997-02-06

    The Immobilized Low-Activity Waste Interim Storage subproject will provide storage capacity for immobilized low-activity waste product sold to the U.S. Department of Energy by the privatization contractor. This statement of work describes the work scope (encompassing definition of new installations and retrofit modifications to four existing grout vaults), to be performed by the Architect-Engineer, in preparation of a conceptual design for the Immobilized Low-Activity Waste Interim Storage Facility.

  19. RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: Groundwater monitoring (40 CFR parts 264/265, subpart F) updated as of July 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-11-01

    The module presents the requirements for groundwater monitoring at interim status and permitted treatment, storage, and disposal facilities. It describes the groundwater monitoring criteria for interim status and permitted facilities. It explains monitoring well placement and outlines the three stages of the groundwater monitoring program for permitted facilities.

  20. Interim Stabilization Equipment Essential and Support Drawing Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    KOCH, M.R.

    The purpose of this document is to list the Interim Stabilization equipment drawings that are classified as Essential or Support drawings. Essential Drawings: Those drawings identified by the facility staff as necessary to directly support the safe operation of the facility or equipment. Support Drawings: Those drawings identified by the facility staff that further describe the design details of structures, systems or components shown on essential drawings.

  1. Planning and Designing School Computer Facilities. Interim Report.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Finance and Administration Div.

    This publication provides suggestions and considerations that may be useful for school jurisdictions developing facilities for computers in schools. An interim report for both use and review, it is intended to assist school system planners in clarifying the specifications needed by the architects, other design consultants, and purchasers involved.…

  2. PROJECT W-551 INTERIM PRETREATMENT SYSTEM PRECONCEPTUAL CANDIDATE TECHNOLOGY DESCRIPTIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MAY TH

    The Office of River Protection (ORP) has authorized a study to recommend and select options for interim pretreatment of tank waste and support Waste Treatment Plant (WTP) low activity waste (LAW) operations prior to startup of all the WTP facilities. The Interim Pretreatment System (IPS) is to be a moderately sized system which separates entrained solids and 137Cs from tank waste for an interim time period while WTP high level waste vitrification and pretreatment facilities are completed. This study's objective is to prepare pre-conceptual technology descriptions that expand the technical detail for selected solid and cesium separation technologies. This revisionmore » includes information on additional feed tanks.« less

  3. 33 CFR 154.1120 - Operating restrictions and interim operating authorization.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Facility Operating in Prince William Sound, Alaska § 154.1120 Operating restrictions and interim operating authorization. (a) The owner or operator of a TAPAA facility may not operate in Prince William Sound, Alaska... practicable, a worst case discharge or a discharge of 200,000 barrels of oil, whichever is grater, in Prince...

  4. Cost Implications of an Interim Storage Facility in the Waste Management System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jarrell, Joshua J.; Joseph, III, Robert Anthony; Howard, Rob L

    2016-09-01

    This report provides an evaluation of the cost implications of incorporating a consolidated interim storage facility (ISF) into the waste management system (WMS). Specifically, the impacts of the timing of opening an ISF relative to opening a repository were analyzed to understand the potential effects on total system costs.

  5. Leveraging Available Data to Support Extension of Transportation Packages Service Life

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dunn, K.; Abramczyk, G.; Bellamy, S.

    Data obtained from testing shipping package materials have been leveraged to support extending the service life of select shipping packages while in nuclear materials transportation. Increasingly, nuclear material inventories are being transferred to an interim storage location where they will reside for extended periods of time. Use of a shipping package to store nuclear materials in an interim storage location has become more attractive for a variety of reasons. Shipping packages are robust and have a qualified pedigree for their performance in normal operation and accident conditions within the approved shipment period and storing nuclear material within a shipping packagemore » results in reduced operations for the storage facility. However, the shipping package materials of construction must maintain a level of integrity as specified by the safety basis of the storage facility through the duration of the storage period, which is typically well beyond the one year transportation window. Test programs have been established to obtain aging data on materials of construction that are the most sensitive/susceptible to aging in certain shipping package designs. The collective data are being used to support extending the service life of shipping packages in both transportation and storage.« less

  6. RCRA, superfund and EPCRA hotline training module. Introduction to: Groundwater monitoring (40 cfr parts 264/265, subpart f) updated July 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-07-01

    The module presents the requirements for groundwater monitoring at interim status and permitted treatment, storage, and disposal facilities (TSDFs) under the Resource Conservation and Recovery Act (RCRA). The goal of the module is to explain the standards and specific requirements for groundwater monitoring programs at interim status and permitted facilities.

  7. 40 CFR Appendix III to Part 265 - EPA Interim Primary Drinking Water Standards

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false EPA Interim Primary Drinking Water Standards III Appendix III to Part 265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Pt....

  8. Defensive efficacy interim design: Dynamic benefit/risk ratio view using probability of success.

    PubMed

    Tang, Zhongwen

    2017-01-01

    Traditional efficacy interim design is based on alpha spending which does not have intuitive interpretation and hence is difficult to communicate with non-statistician colleagues. The alpha-spending approach is based on efficacy alone and hence does not have the flexibility to incorporate newly emerged safety signal. Newly emerged safety signal may nullify the originally set efficacy boundary. In contrast, the probability of success (POS) concept has intuitive interpretation and hence can facilitate our communication with non-statistician colleagues and help to obtain health authority (HA) buying. The success criteria of POS are not restricted to statistical significance. Hence, POS has the capability to incorporate both efficacy and safety information. We propose to use POS and its credible interval to design efficacy interim. In the proposed method, the efficacy boundary is adjustable to offset newly emerged safety signal.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nicholson, J. C.

    Performance metrics for evaluating commercial fixatives are often not readily available for important parameters that must be considered per the facility safety basis and the facility Basis for Interim Operations (BIO). One such parameter is the behavior of such materials in varied, “non-ideal” conditions where ideal is defined as 75 °F, 40% RH. Coupled with the inherent flammable nature of the fixative materials that can act to propagate flame along surfaces that are otherwise fireproof (concrete, sheet metal), much is left unknown when considering the safety basis implications for introducing these materials into nuclear facilities. Through SRNL’s efforts, three (3)more » fixatives, one (1) decontamination gel, and six (6) intumescent coatings were examined for their responses to environmental conditions to determine whether these materials were impervious to non-nominal temperatures and humidities that may be found in nuclear facilities. Characteristics that were examined included set-to-touch time, dust free time, and adhesion testing of the fully cured compounds. Of these ten materials, three were two-part epoxy materials while the other seven consisted of only one constituent. The results show that the epoxies tested are unable to cure in sub-freezing temperatures, with the low temperatures inhibiting crosslinking to a very significant degree. These efforts show significant inhibiting of performance for non-nominal environmental conditions, something that must be addressed both in the decision process for a fixative material to apply and per the safety basis to ensure the accurate flammability and material at risk is calculated.« less

  10. Taipower`s radioactive waste management program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, B.C.C.

    1996-09-01

    Nuclear safety and radioactive waste management are the two major concerns of nuclear power in Taiwan. Recognizing that it is an issue imbued with political and social-economic concerns, Taipower has established an integrated nuclear backend management system and its associated financial and mechanism. For LLW, the Orchid Island storage facility will play an important role in bridging the gap between on-site storage and final disposal of LLW. Also, on-site interim storage of spent fuel for 40 years or longer will provide Taipower with ample time and flexibility to adopt the suitable alternative of direct disposal or reprocessing. In other words,more » by so exercising interim storage option, Taipower will be in a comfortable position to safely and permanently dispose of radwaste without unduly forgoing the opportunities of adopting better technologies or alternatives. Furthermore, Taipower will spare no efforts to communicate with the general public and make her nuclear backend management activities accountable to them.« less

  11. Characterization of the radiation environment for a large-area interim spent-nuclear-fuel storage facility

    NASA Astrophysics Data System (ADS)

    Fortkamp, Jonathan C.

    Current needs in the nuclear industry and movements in the political arena indicate that authorization may soon be given for development of a federal interim storage facility for spent nuclear fuel. The initial stages of the design work have already begun within the Department of Energy and are being reviewed by the Nuclear Regulatory Commission. This dissertation addresses the radiation environment around an interim spent nuclear fuel storage facility. Specifically the dissertation characterizes the radiation dose rates around the facility based on a design basis source term, evaluates the changes in dose due to varying cask spacing configurations, and uses these results to define some applicable health physics principles for the storage facility. Results indicate that dose rates from the facility are due primarily from photons from the spent fuel and Co-60 activation in the fuel assemblies. In the modeled cask system, skyshine was a significant contribution to dose rates at distances from the cask array, but this contribution can be reduced with an alternate cask venting system. With the application of appropriate health physics principles, occupation doses can be easily maintained far below regulatory limits and maintained ALARA.

  12. Explanation of Significant Differences for the Record of Decision for Interim Actions in Zone 1, East Tennessee Technology Park, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bechtel Jacobs

    2011-02-01

    Zone 1 is a 1400-acre area outside the fence of the main plant at The East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee. The Record of Decision for Interim Actions in Zone, ETTP (Zone 1 Interim ROD) (DOE 2002) identifies the remedial actions for contaminated soil, buried waste, and subsurface infrastructure necessary to protect human health and to limit further contamination of groundwater. Since the Zone 1 Interim Record of Decision (ROD) was signed, new information has been obtained that requires the remedy to be modified as follows: (1) Change the end use in Contractor's Spoil Area (CSA) frommore » unrestricted industrial to recreational; (2) Remove Exposure Units (EU5) ZI-50, 51, and 52 from the scope of the Zone I Interim ROD; (3) Change the end use of the duct bank corridor from unrestricted industrial to restricted industrial; and (4) Remove restriction for the disturbance of soils below 10 feet in Exposure Unit (EU) Z1-04. In accordance with 40 Code of Federal Regulations (CFR) 300.435, these scope modifications are a 'significant' change to the Zone 1 Interim ROD. In accordance with CERCLA Sect. 117 (c) and 40 CFR 300.435 (c)(2)(i), such a significant change is documented with an Explanation of Significant Differences (ESD). The purpose of this ESD is to make the changes listed above. This ESD is part of the Administrative Record file, and it, and other information supporting the selected remedy, can be found at the DOE Information Center, 475 Oak Ridge Turnpike, Oak Ridge, Tennessee 37830, from 8:00 a.m. to 5:00 p.m., Monday through Friday. The ORR is located in Roane and Anderson counties, within and adjacent to the corporate city limits of Oak Ridge, Tennessee. ETTP is located in Roane County near the northwest corner of the ORR. ETTP began operation during World War II as part of the Manhattan Project. The original mission of ETTP was to produce enriched uranium for use in atomic weapons. The plant produced enriched uranium from 1945 until 1985. Uranium production was terminated in 1987. ORR was placed on the National Priorities List in 1989, so remediation activities are conducted under CERCLA. The primary contaminants of concern at ETTP follow: (1) In groundwater - volatile organic compounds (VOCs) at multiple locations (trichloroethene is generally the most prevalent compound); (2) In sediment - inorganic elements, radionuclides, and polychlorinated biphenyls; (3) In soil - inorganic elements, radionuclides, semivolatile organic compounds (particularly the polycyclic aromatic hydrocarbons), and VOCs; and (4) In facilities - radionuclides and polychlorinated biphenyls (abandoned facilities also pose a safety and health hazard to workers.) The purposes of the remedial actions selected in the Zone 1 Interim ROD are to allow unrestricted industrial use down to 10 feet and to remediate potential sources of groundwater contamination. Following is a summary of the major components of the Zone 1 Interim ROD remedy: (1) Excavation of the Blair Quarry burial area and associated contaminated soil; (2) Excavation of miscellaneous contaminated soil in the K-895 Cylinder Destruct Facility area and in the Powerhouse Area; (3) Removal of sludge and demolition of the K-710 sludge beds and Imhoff tanks; (4) Implementation of land use controls (LUCs); and (5) Characterization of soil and remediation of areas that exceed remediation levels.« less

  13. The Time Needed to Implement the Blue Ribbon Commission Recommendation on Interim Storage - 13124

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Voegele, Michael D.; Vieth, Donald

    2013-07-01

    The report of the Blue Ribbon Commission on America's Nuclear Future [1] makes a number of important recommendations to be considered if Congress elects to redirect U.S. high-level radioactive waste disposal policy. Setting aside for the purposes of this discussion any issues related to political forces leading to stopping progress on the Yucca Mountain project and driving the creation of the Commission, an important recommendation of the Commission was to institute prompt efforts to develop one or more consolidated storage facilities. The Blue Ribbon Commission noted that this recommended strategy for future storage and disposal facilities and operations should bemore » implemented regardless of what happens with Yucca Mountain. It is too easy, however, to focus on interim storage as an alternative to geologic disposal. The Blue Ribbon Commission report does not go far enough in addressing the magnitude of the contentious problems associated with reopening the issues of relative authorities of the states and federal government with which Congress wrestled in crafting the Nuclear Waste Policy Act [2]. The Blue Ribbon Commission recommendation for prompt adoption of an interim storage program does not appear to be fully informed about the actions that must be taken, the relative cost of the effort, or the realistic time line that would be involved. In essence, the recommendation leaves to others the details of the systems engineering analyses needed to understand the nature and details of all the operations required to reach an operational interim storage facility without derailing forever the true end goal of geologic disposal. The material presented identifies a number of impediments that must be overcome before the country could develop a centralized federal interim storage facility. In summary, and in the order presented, they are: 1. Change the law, HJR 87, PL 107-200, designating Yucca Mountain for the development of a repository. 2. Bring new nuclear waste legislation to the floor of the Senate, overcoming existing House support for Yucca Mountain; 3. Change the longstanding focus of Congress from disposal to storage; 4. Change the funding concepts embodied in the Nuclear Waste Policy Act to allow the Nuclear Waste fund to be used to pay for interim storage; 5. Reverse the Congressional policy not to give states or tribes veto or consent authority, and to reserve to Congress the authority to override a state or tribal disapproval; 6. Promulgate interim storage facility siting regulations to reflect the new policies after such changes to policy and law; 7. Complete already underway changes to storage and transportation regulations, possibly incorporating changes to reflect changes to waste disposal law; 8. Promulgate new repository siting regulations if the interim storage facility is to support repository development; 9. Identify volunteer sites, negotiate agreements, and get Congressional approval for negotiated benefits packages; 10. Design, License and develop the interim storage facility. The time required to accomplish these ten items depends on many factors. The estimate developed assumes that certain of the items must be completed before other items are started; given past criticisms of the current program, such an assumption appears appropriate. Estimated times for completion of individual items are based on historical precedent. (authors)« less

  14. Evaluation of Environmental Conditions on the Curing Of Commercial Fixative and Intumescent Coatings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nicholson, J. C.

    2016-09-26

    Performance metrics for evaluating commercial fixatives are often not readily available for important parameters that must be considered per the facility safety basis and the facility Basis for Interim Operations (BIO). One such parameter is the behavior of such materials in varied, “non-ideal” conditions where ideal is defined as 75 °F, 40% RH. Coupled with the inherent flammable nature of the fixative materials that can act to propagate flame along surfaces that are otherwise fireproof (concrete, sheet metal), much is left unknown when considering the safety basis implications for introducing these materials into nuclear facilities. Through SRNL’s efforts, three (3)more » fixatives, one (1) decontamination gel, and six (6) intumescent coatings were examined for their responses to environmental conditions to determine whether these materials were impervious to non-nominal temperatures and humidities that may be found in nuclear facilities. Characteristics that were examined included set-to-touch time, dust free time, and adhesion testing of the fully cured compounds. Of these ten materials, three were two-part epoxy materials while the other seven consisted of only one constituent. The results show that the epoxies tested are unable to cure in sub-freezing temperatures, with the low temperatures inhibiting crosslinking to a very significant degree. These efforts show significant inhibiting of performance for non-nominal environmental conditions, something that must be addressed both in the decision process for a fixative material to apply and per the safety basis to ensure the accurate flammability and material at risk is calculated.« less

  15. Application of Framework for Integrating Safety, Security and Safeguards (3Ss) into the Design Of Used Nuclear Fuel Storage Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Badwan, Faris M.; Demuth, Scott F

    Department of Energy’s Office of Nuclear Energy, Fuel Cycle Research and Development develops options to the current commercial fuel cycle management strategy to enable the safe, secure, economic, and sustainable expansion of nuclear energy while minimizing proliferation risks by conducting research and development focused on used nuclear fuel recycling and waste management to meet U.S. needs. Used nuclear fuel is currently stored onsite in either wet pools or in dry storage systems, with disposal envisioned in interim storage facility and, ultimately, in a deep-mined geologic repository. The safe management and disposition of used nuclear fuel and/or nuclear waste is amore » fundamental aspect of any nuclear fuel cycle. Integrating safety, security, and safeguards (3Ss) fully in the early stages of the design process for a new nuclear facility has the potential to effectively minimize safety, proliferation, and security risks. The 3Ss integration framework could become the new national and international norm and the standard process for designing future nuclear facilities. The purpose of this report is to develop a framework for integrating the safety, security and safeguards concept into the design of Used Nuclear Fuel Storage Facility (UNFSF). The primary focus is on integration of safeguards and security into the UNFSF based on the existing Nuclear Regulatory Commission (NRC) approach to addressing the safety/security interface (10 CFR 73.58 and Regulatory Guide 5.73) for nuclear power plants. The methodology used for adaptation of the NRC safety/security interface will be used as the basis for development of the safeguards /security interface and later will be used as the basis for development of safety and safeguards interface. Then this will complete the integration cycle of safety, security, and safeguards. The overall methodology for integration of 3Ss will be proposed, but only the integration of safeguards and security will be applied to the design of the UNFSF. The framework for integration of safeguards and security into the UNFSF will include 1) identification of applicable regulatory requirements, 2) selection of a common system that share dual safeguard and security functions, 3) development of functional design criteria and design requirements for the selected system, 4) identification and integration of the dual safeguards and security design requirements, and 5) assessment of the integration and potential benefit.« less

  16. Intelligent cruise control field operational test : interim report

    DOT National Transportation Integrated Search

    1997-03-01

    This interim document reports on a cooperative agreement between NHTSA and UMTRI entitled Intelligent Cruise Control (ICC) Field Operational Test (FOT). The overarching goal of the work is to characterize safety and comfort issues that are fundamenta...

  17. 7 CFR 1737.41 - Procedure for obtaining approval.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RUS financing. (3) The proposed interim financing presents unacceptable loan security risks to RUS, or..., DEPARTMENT OF AGRICULTURE PRE-LOAN POLICIES AND PROCEDURES COMMON TO INSURED AND GUARANTEED TELECOMMUNICATIONS LOANS Interim Financing of Construction of Telephone Facilities § 1737.41 Procedure for obtaining...

  18. Toxic Hazards Research Unit

    NASA Technical Reports Server (NTRS)

    Macewen, J. D.; Vernot, E. H.

    1971-01-01

    The activities of the Toxic Hazards Research Unit (THRU) for the period of June 1970 through May 1971 reviewed. Modification of the animal exposure facilities primarily for improved human safety but also for experimental integrity and continuity are discussed. Acute toxicity experiments were conducted on hydrogen fluoride (HF), hydrogen chloride (HCl), nitrogen dioxide (NO2), and hydrogen cyanide (HCN) both singly and in combination with carbon dioxide (CO). Additional acute toxicity experiments were conducted on oxygen difluoride (OF2) and chlorine pentafluoride (ClF5). Subacute toxicity studies were conducted on methylisobutylketone and dichloromethane (methylene dichloride). The interim results of further chronic toxicity experiments on monomethylhydrazine (MMH) are also described.

  19. Medicare and Medicaid programs; rural hospitals: provision of long-term care services (swing-bed provision); flexibility in application of standards--Health Care Financing Administration. Interim final rule with comment period.

    PubMed

    1982-07-20

    These regulations implement sections 904 and 949 of Pub. L. 96-499, the Omnibus Reconciliation Act of 1980. Under section 904 (the swing-bed provision), certain small, rural hospitals may use their inpatient facilities to furnish skilled nursing facility (SNF) services to Medicare and Medicaid beneficiaries, and intermediate care facility (ICF) services to Medicaid beneficiaries. These hospitals will be reimbursed at rates appropriate for those services, which are generally lower than hospital rates. This statutory provision is intended to encourage the most efficient and effective use of inpatient hospital beds for delivery of either hospital or SNF and ICF services. Under section 949, rural hospitals of 50 or fewer beds may be exempted from certain personnel standards in the conditions of participation for hospitals. This exemption applies only to the extent that it does not jeopardize or adversely affect the health and safety of patients.

  20. Long-term storage facility for reactor compartments in Sayda Bay - German support for utilization of nuclear submarines in Russia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wolff, Dietmar; Voelzke, Holger; Weber, Wolfgang

    2007-07-01

    The German-Russian project that is part of the G8 initiative on Global Partnership Against the Spread of Weapons and Materials of Mass Destruction focuses on the speedy construction of a land-based interim storage facility for nuclear submarine reactor compartments at Sayda Bay near Murmansk. This project includes the required infrastructure facilities for long-term storage of about 150 reactor compartments for a period of about 70 years. The interim storage facility is a precondition for effective activities of decommissioning and dismantlement of almost all nuclear-powered submarines of the Russian Northern Fleet. The project also includes the establishment of a computer-assisted wastemore » monitoring system. In addition, the project involves clearing Sayda Bay of other shipwrecks of the Russian navy. On the German side the project is carried out by the Energiewerke Nord GmbH (EWN) on behalf of the Federal Ministry of Economics and Labour (BMWi). On the Russian side the Kurchatov Institute holds the project management of the long-term interim storage facility in Sayda Bay, whilst the Nerpa Shipyard, which is about 25 km away from the storage facility, is dismantling the submarines and preparing the reactor compartments for long-term interim storage. The technical monitoring of the German part of this project, being implemented by BMWi, is the responsibility of the Federal Institute for Materials Research and Testing (BAM). This paper gives an overview of the German-Russian project and a brief description of solutions for nuclear submarine disposal in other countries. At Nerpa shipyard, being refurbished with logistic and technical support from Germany, the reactor compartments are sealed by welding, provided with biological shielding, subjected to surface treatment and conservation measures. Using floating docks, a tugboat tows the reactor compartments from Nerpa shipyard to the interim storage facility at Sayda Bay where they will be left on the on-shore concrete storage space to allow the radioactivity to decay. For transport of reactor compartments at the shipyard, at the dock and at the storage facility, hydraulic keel blocks, developed and supplied by German subcontractors, are used. In July 2006 the first stage of the reactor compartment storage facility was commissioned and the first seven reactor compartments have been delivered from Nerpa shipyard. Following transports of reactor compartments to the storage facility are expected in 2007. (authors)« less

  1. Improvement of operational safety of dual-purpose transport packaging set for naval SNF in storage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guskov, Vladimir; Korotkov, Gennady; Barnes, Ella

    2007-07-01

    Available in abstract form only. Full text of publication follows: In recent ten years a new technology of management of irradiated nuclear fuel (SNF) at the final stage of fuel cycle has been intensely developing on a basis of a new type of casks used for interim storage of SNF and subsequent transportation therein to the place of processing, further storage or final disposal. This technology stems from the concept of a protective cask which provides preservation of its content (SNF) and fulfillment of all other safety requirements for storage and transportation of SNF. Radiation protection against emissions and non-distributionmore » of activity outside the cask is ensured by physical barriers, i.e. all-metal or composite body, shells, inner cavities for irradiated fuel assemblies (SFA), lids with sealing systems. Residual heat release of SFA is discharged to the environment by natural way: through emission and convection of surrounding air. By now more than 100 dual purpose packaging sets TUK-108/1 are in operation in the mode of interim storage and transportation of SNF from decommissioned nuclear powered submarines (NPS). In accordance with certificate, spent fuel is stored in TUK-108/1 on the premises of plants involved in NPS dismantlement for 2 years, whereupon it is transported for processing to PO Mayak. At one Far Eastern plant Zvezda involved in NPS dismantlement there arose a complicated situation due to necessity to extend period of storage of SNF in TUK- 108/1. To ensure safety over a longer period of storage of SNF in TUK-108/1 it is essential to modify conditions of storage by removing of residual water and filling the inner cavity of the cask with an inert gas. Within implementation of the international 1.1- 2 project Development of drying technology for the cask TUK-108/1 intended for naval SNF under the Program, there has been developed the technology of preparation of the cask for long-term storage of SNF in TUK-108/1, the design of a mobile TUK-108/1 drying facility; a pilot facility has been manufactured. This report describes key issues of cask drying technology, justification of terms of dry storage of naval SNF in no-108/1, design features of the mobile drying facility, results of tests of the pilot facility at the Far Eastern plant Zvezda. (authors)« less

  2. 42 CFR 93.401 - Interaction with other offices and interim actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

  3. 42 CFR 93.401 - Interaction with other offices and interim actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

  4. 42 CFR 93.401 - Interaction with other offices and interim actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

  5. 42 CFR 93.401 - Interaction with other offices and interim actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC... offices and funding components at any time to permit them to make appropriate interim responses to protect... making decisions about the award or continuation of funding. Research Misconduct Issues ...

  6. The role of the Data and Safety Monitoring Board in a clinical trial: The CRISIS Study

    PubMed Central

    Holubkov, Richard; Casper, T. Charles; Dean, J. Michael; Anand, K. J. S.; Zimmerman, Jerry; Meert, Kathleen L.; Newth, Christopher J. L.; Berger, John; Harrison, Rick; Willson, Douglas F.; Nicholson, Carol

    2012-01-01

    Objective Randomized clinical trials are commonly overseen by a data and safety monitoring board (DSMB) comprised of experts in medicine, ethics, and biostatistics. DSMB responsibilities include protocol approval, interim review of study enrollment, protocol compliance, safety, and efficacy data. DSMB decisions can affect study design and conduct, as well as reported findings. Researchers must incorporate DSMB oversight into the design, monitoring, and reporting of randomized trials. Design Case study, narrative review. Methods The DSMB’s role during the comparative pediatric Critical Illness Stress-Induced Immune Suppression (CRISIS) Prevention Trial is described. Findings The NIH-appointed CRISIS DSMB was charged with monitoring sample size adequacy and feasibility, safety with respect to adverse events and 28-day mortality, and efficacy with respect to the primary nosocomial infection/sepsis outcome. The Federal Drug Administration also requested DSMB interim review before opening CRISIS to children below one year of age. The first interim analysis found higher 28-day mortality in one treatment arm. The DSMB maintained trial closure to younger children, and requested a second interim data review six months later. At this second meeting, mortality was no longer of concern, while a weak efficacy trend of lower infection/sepsis rates in one study arm emerged. As over 40% of total patients had been enrolled, the DSMB elected to examine conditional power, and unmask treatment arm identities. Upon finding somewhat greater efficacy in the placebo arm, the DSMB recommended stopping CRISIS due to futility. Conclusions The design and operating procedures of a multicenter randomized trial must consider a pivotal DSMB role. Maximum study design flexibility must be allowed, and investigators must be prepared for protocol modifications due to interim findings. The DSMB must have sufficient clinical and statistical expertise to assess potential importance of interim treatment differences in the setting of multiple looks at accumulating data with numerous outcomes and subgroups. PMID:23392377

  7. 14 CFR 171.271 - Installation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing System (ISMLS) § 171.271 Installation requirements. (a) The ISMLS facility must be permanent in nature, located... codes, FCC licensing requirements, and paragraphs (a) and (c) of § 171.261. (b) The ISMLS facility must...

  8. 14 CFR 171.271 - Installation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing System (ISMLS) § 171.271 Installation requirements. (a) The ISMLS facility must be permanent in nature, located... codes, FCC licensing requirements, and paragraphs (a) and (c) of § 171.261. (b) The ISMLS facility must...

  9. 14 CFR 171.271 - Installation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing System (ISMLS) § 171.271 Installation requirements. (a) The ISMLS facility must be permanent in nature, located... codes, FCC licensing requirements, and paragraphs (a) and (c) of § 171.261. (b) The ISMLS facility must...

  10. Safety evaluation for packaging transportation of equipment for tank 241-C-106 waste sluicing system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Calmus, D.B.

    1994-08-25

    A Waste Sluicing System (WSS) is scheduled for installation in nd waste storage tank 241-C-106 (106-C). The WSS will transfer high rating sludge from single shell tank 106-C to double shell waste tank 241-AY-102 (102-AY). Prior to installation of the WSS, a heel pump and a transfer pump will be removed from tank 106-C and an agitator pump will be removed from tank 102-AY. Special flexible receivers will be used to contain the pumps during removal from the tanks. After equipment removal, the flexible receivers will be placed in separate containers (packagings). The packaging and contents (packages) will be transferredmore » from the Tank Farms to the Central Waste Complex (CWC) for interim storage and then to T Plant for evaluation and processing for final disposition. Two sizes of packagings will be provided for transferring the equipment from the Tank Farms to the interim storage facility. The packagings will be designated as the WSSP-1 and WSSP-2 packagings throughout the remainder of this Safety Evaluation for Packaging (SEP). The WSSP-1 packagings will transport the heel and transfer pumps from 106-C and the WSSP-2 packaging will transport the agitator pump from 102-AY. The WSSP-1 and WSSP-2 packagings are similar except for the length.« less

  11. Orion EM-1 Interim Cryogenic Propulsion Stage (ICPS) move from HIF to DOC

    NASA Image and Video Library

    2017-04-12

    The Orion EM-1 Interim Cryogenic Propulsion Stage is moved from the Horizontal Integration Facility (HIF) to the Delta Operations Center (DOC) at Cape Canaveral Air Force Station to continue processing for it's future mission on the Space Launch System rocket.

  12. 40 CFR 270.72 - Changes during interim status.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the changes to the facility exceeds 50 percent of the capital cost of a comparable entirely new... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Changes during interim status. 270.72 Section 270.72 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...

  13. 76 FR 75913 - Notice of Lodging of Modification of Consent Decree Under the Clean Water Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... (``Regulated Bacteria'') and to comply with interim effluent limitations for those pollutants. The proposed Modification provides new, more stringent interim effluent limitations for Regulated Bacteria and requires... effluent limitations for Regulated Bacteria set forth in the Facility's National Pollutant Discharge...

  14. 42 CFR 93.401 - Interaction with other offices and interim actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Interaction with other offices and interim actions. 93.401 Section 93.401 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC...

  15. Cost Sensitivity Analysis for Consolidated Interim Storage of Spent Fuel: Evaluating the Effect of Economic Environment Parameters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cumberland, Riley M.; Williams, Kent Alan; Jarrell, Joshua J.

    This report evaluates how the economic environment (i.e., discount rate, inflation rate, escalation rate) can impact previously estimated differences in lifecycle costs between an integrated waste management system with an interim storage facility (ISF) and a similar system without an ISF.

  16. 76 FR 72006 - Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    .... Discussion Uranium recovery facility licensees, including in-situ recovery facilities and conventional... Recovery Facility Surveys of Radon and Radon Progeny in Air and Demonstrations of Compliance AGENCY... Staff Guidance, ``Evaluations of Uranium Recovery Facility Surveys of Radon and Radon Progeny in Air and...

  17. 42 CFR 57.1505 - Approval of applications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Loan Guarantees and Interest Subsidies to Assist in Construction of Teaching Facilities for Health Profession... loan, whichever is longer or in the case of interim facilities, the term of the guaranteed loan, and (2...

  18. 75 FR 4344 - Foreign-Trade Zone 22-Chicago, IL Application for Temporary/Interim Manufacturing Authority LG...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Docket T-1-2010] Foreign-Trade Zone 22--Chicago, IL Application for Temporary/ Interim Manufacturing Authority LG Electronics MobileComm USA, Inc... Electronics MobileComm USA, Inc. (LGEMU) facility, located in Bolingbrook, Illinois. The application was filed...

  19. Flammability, Offgassing, and Compatibility Requirements and Test Procedures. Interim NASA Technical Standard

    NASA Technical Reports Server (NTRS)

    2009-01-01

    This Interim Standard establishes requirements for evaluation, testing, and selection of materials that are intended for use in space vehicles, associated Ground Support Equipment (GSE), and facilities used during assembly, test, and flight operations. Included are requirements, criteria, and test methods for evaluating the flammability, offgassing, and compatibility of materials.

  20. 40 CFR 264.3 - Relationship to interim status standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Relationship to interim status standards. 264.3 Section 264.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES General § 264.3 Relationship to...

  1. 16 CFR 1209.38 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.38 Records. (a) Establishment and maintenance. Each... product specification containing all information required by § 1209.35. (This includes information...

  2. 16 CFR 1209.37 - Corrective actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.37 Corrective actions. (a) Test failure... insulation product itself. Corrective action may consist of equipment adjustment, equipment repair, equipment...

  3. NASA/Navy Benchmarking Exchange (NNBE). Volume 1. Interim Report. Navy Submarine Program Safety Assurance

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The NASA/Navy Benchmarking Exchange (NNBE) was undertaken to identify practices and procedures and to share lessons learned in the Navy's submarine and NASA's human space flight programs. The NNBE focus is on safety and mission assurance policies, processes, accountability, and control measures. This report is an interim summary of activity conducted through October 2002, and it coincides with completion of the first phase of a two-phase fact-finding effort.In August 2002, a team was formed, co-chaired by senior representatives from the NASA Office of Safety and Mission Assurance and the NAVSEA 92Q Submarine Safety and Quality Assurance Division. The team closely examined the two elements of submarine safety (SUBSAFE) certification: (1) new design/construction (initial certification) and (2) maintenance and modernization (sustaining certification), with a focus on: (1) Management and Organization, (2) Safety Requirements (technical and administrative), (3) Implementation Processes, (4) Compliance Verification Processes, and (5) Certification Processes.

  4. 40 CFR 270.72 - Changes during interim status.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reconstruction of the hazardous waste management facility. Reconstruction occurs when the capital investment in the changes to the facility exceeds 50 percent of the capital cost of a comparable entirely new...

  5. 14 CFR 171.267 - Glide path automatic monitor system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... control points when any of the following occurs: (1) A shift of the mean ISMLS glide path angle equivalent... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave...

  6. 14 CFR 171.267 - Glide path automatic monitor system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... control points when any of the following occurs: (1) A shift of the mean ISMLS glide path angle equivalent... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave...

  7. 14 CFR 171.267 - Glide path automatic monitor system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... control points when any of the following occurs: (1) A shift of the mean ISMLS glide path angle equivalent... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave...

  8. 78 FR 48503 - Proposed Revision to Missiles Generated by Extreme Winds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ...-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants: LWR..., ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants,'' and Interim Staff Guidance DC... and Hurricane Missiles for Nuclear Power Plants'' (ADAMS, Accession No. ML110940300), and Interim...

  9. 16 CFR 1209.33 - Reasonable testing program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1209.33 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.33 Reasonable testing program. (a) General. Section 14(a) of the Consumer Product Safety Act (15 U.S.C. 2063(a)) requires each manufacturer...

  10. 16 CFR 1209.36 - Production testing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.36 Production testing. (a) General... manufactured to demonstrate that the product being manufactured is substantially similar to the product which...

  11. 16 CFR 1209.32 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.32 Definitions. In addition to the... samples of the cellulose insulation being produced to demonstrate that the product meets the requirements...

  12. Radon exposure at a radioactive waste storage facility.

    PubMed

    Manocchi, F H; Campos, M P; Dellamano, J C; Silva, G M

    2014-06-01

    The Waste Management Department of Nuclear and Energy Research Institute (IPEN) is responsible for the safety management of the waste generated at all internal research centers and that of other waste producers such as industry, medical facilities, and universities in Brazil. These waste materials, after treatment, are placed in an interim storage facility. Among them are (226)Ra needles used in radiotherapy, siliceous cake arising from conversion processes, and several other classes of waste from the nuclear fuel cycle, which contain Ra-226 producing (222)Rn gas daughter.In order to estimate the effective dose for workers due to radon inhalation, the radon concentration at the storage facility has been assessed within this study. Radon measurements have been carried out through the passive method with solid-state nuclear track detectors (CR-39) over a period of nine months, changing detectors every month in order to determine the long-term average levels of indoor radon concentrations. The radon concentration results, covering the period from June 2012 to March 2013, varied from 0.55 ± 0.05 to 5.19 ± 0.45 kBq m(-3). The effective dose due to (222)Rn inhalation was further assessed following ICRP Publication 65.

  13. 40 CFR 267.2 - What is the relationship to interim status standards?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What is the relationship to interim status standards? 267.2 Section 267.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE FACILITIES OPERATING UNDER A STANDARDIZED PERMIT General § 267.2...

  14. 14 CFR 171.265 - Glide path performance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... impressed on the microwave carrier of the radiated glide slope signal in the form of a unique summation of... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave... assumption that the aircraft is heading directly toward the facility. (a) The glide slope antenna system must...

  15. 14 CFR 171.265 - Glide path performance requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... impressed on the microwave carrier of the radiated glide slope signal in the form of a unique summation of... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave... assumption that the aircraft is heading directly toward the facility. (a) The glide slope antenna system must...

  16. 14 CFR 171.265 - Glide path performance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... impressed on the microwave carrier of the radiated glide slope signal in the form of a unique summation of... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave... assumption that the aircraft is heading directly toward the facility. (a) The glide slope antenna system must...

  17. 14 CFR 171.265 - Glide path performance requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... impressed on the microwave carrier of the radiated glide slope signal in the form of a unique summation of... TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave... assumption that the aircraft is heading directly toward the facility. (a) The glide slope antenna system must...

  18. Developing a concept for a national used fuel interim storage facility in the United States

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lewis, Donald Wayne

    2013-07-01

    In the United States (U.S.) the nuclear waste issue has plagued the nuclear industry for decades. Originally, spent fuel was to be reprocessed but with the threat of nuclear proliferation, spent fuel reprocessing has been eliminated, at least for now. In 1983, the Nuclear Waste Policy Act of 1982 [1] was established, authorizing development of one or more spent fuel and high-level nuclear waste geological repositories and a consolidated national storage facility, called a 'Monitored Retrievable Storage' facility, that could store the spent nuclear fuel until it could be placed into the geological repository. Plans were under way to buildmore » a geological repository, Yucca Mountain, but with the decision by President Obama to terminate the development of Yucca Mountain, a consolidated national storage facility that can store spent fuel for an interim period until a new repository is established has become very important. Since reactor sites have not been able to wait for the government to come up with a storage or disposal location, spent fuel remains in wet or dry storage at each nuclear plant. The purpose of this paper is to present a concept developed to address the DOE's goals stated above. This concept was developed over the past few months by collaboration between the DOE and industry experts that have experience in designing spent nuclear fuel facilities. The paper examines the current spent fuel storage conditions at shutdown reactor sites, operating reactor sites, and the type of storage systems (transportable versus non-transportable, welded or bolted). The concept lays out the basis for a pilot storage facility to house spent fuel from shutdown reactor sites and then how the pilot facility can be enlarged to a larger full scale consolidated interim storage facility. (authors)« less

  19. 16 CFR § 1209.1 - Scope and application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...§ 1209.1 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS.... This part 1209, an interim consumer product safety standard, prescribes flame resistance and corrosiveness requirements for cellulose insulation that is a consumer product. These requirements are intended...

  20. 16 CFR 1209.34 - Qualification testing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....34 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.34 Qualification testing. (a... labelers, or importers may select samples for qualification testing of a product in any manner they desire. ...

  1. 16 CFR 1209.40 - Certification responsibility, multiple parties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Certification responsibility, multiple parties. 1209.40 Section 1209.40 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.40...

  2. 16 CFR 1209.35 - Product specification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Product specification. 1209.35 Section 1209.35 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.35 Product specification. (a...

  3. Overview of Federal Motor Carrier Safety Administration safety training research for new entrant motor carriers : [research brief].

    DOT National Transportation Integrated Search

    2015-07-01

    In 2002, the Federal Motor Carrier Safety Administration (FMCSA) issued the New Entrant Program Interim Final Rule in response to the requirement in the Motor Carrier Safety Improvement Act of 1999. The requirement in the Act was based on research fi...

  4. Comparison of RCRA SWMU Corrective Action and CERCLA Remedial Action

    DTIC Science & Technology

    1991-09-30

    4. TITLE AND SUBTITLE 5 . FUNDING NUMBERS Comparison of RCRA SWMU Corrective Action and CERCLA Remedial Action 6. AUTHOR(S) Sam Capps Rupe, Major -1...Interim Status for TSD Facilities .................... 19 5 . Closure and Postclosure Requirements for TSD Facilities ........... 25 D. State Role... 65 1. RCRA Facility Assessment . ............................... 65 2. RCRA Facility Investigation . .............................. 66 3

  5. 16 CFR Figure 5 to Subpart A of... - Zero Reference Point Related to Detecting Plane

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Plane 5 Figure 5 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt... Plane EC03OC91.035 ...

  6. 16 CFR 1209.39 - Certification of compliance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Certification of compliance. 1209.39 Section 1209.39 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.39 Certification of compliance. (a...

  7. 16 CFR 1209.41 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Effective date. 1209.41 Section 1209.41 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.41 Effective date. The requirements of this...

  8. Storage for greater-than-Class C low-level radioactive waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Beitel, G.A.

    1991-12-31

    EG and G Idaho, Inc., at the Idaho National Engineering Laboratory (INEL) is actively pursuing technical storage alternatives for greater-than-Class C low-level radioactive waste (GTCC LLW) until a suitable licensed disposal facility is operating. A recently completed study projects that between 2200 and 6000 m{sup 3} of GTCC LLW will be generated by the year 2035; the base case estimate is 3250 m{sup 3}. The current plan envisions a disposal facility available as early as the year 2010. A long-term dedicated storage facility could be available in 1997. In the meantime, it is anticipated that a limited number of sealedmore » sources that are no longer useful and have GTCC concentrations of radionuclides will require storage. Arrangements are being made to provide this interim storage at an existing DOE waste management facility. All interim stored waste will subsequently be moved to the dedicated storage facility once it is operating. Negotiations are under way to establish a host site for interim storage, which may be operational, at the earliest, by the second quarter of 1993. Two major activities toward developing a long-term dedicated storage facility are ongoing. (a) An engineering study, which explores costs for alternatives to provide environmentally safe storage and satisfy all regulations, is being prepared. Details of some of the findings of that study will be presented. (b) There is also an effort under way to seek the assistance of one or more private companies in providing dedicated storage. Alternatives and options will be discussed.« less

  9. 75 FR 81337 - Interim Final Regulation Deferring the Reporting Date for Certain Data Elements Required Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... Meat processing facilities. 311411 Frozen fruit, juice, and vegetable manufacturing facilities. 311421... volume conversion factor. Y 98.256(m)(3) Only total quantity of crude oil plus the quantity of...

  10. Hazmat storage requires a zero-risk attitude

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roer, M.

    It does not matter whether a company accumulates, transports, treats, stores or disposes hazardous chemicals--it is held responsible by the Environmental Protection Agency for environmental damage caused by leaks and spills. As a result, facilities must take sufficient precautions to minimize damage and avoid liability under the federal Comprehensive Environmental Response, Compensation and Liability Act, applicable state statute, Occupational Safety and Health Administration regulations, and Department of Transportation (DOT) requirements. A facility may accumulate hazardous waste onsite--without a permit or having interim status--for 90 days or less, or up to 120 days with an extension. However, certain conditions must bemore » met. Companies can determine their specific storage requirements in accordance with federal regulations and local requirements. To help these companies, various laboratories have developed procedures for examining, testing, listing and labeling hazardous materials storage lockers. A pre-examination service and accompanying approval label should provide generators and authorities with an increased level of confidence when selecting storage containment systems.« less

  11. Regulatory Supervision of Radiological Protection in the Russian Federation as Applied to Facility Decommissioning and Site Remediation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sneve, M.K.; Shandala, N.K.

    2007-07-01

    The Russian Federation is carrying out major work to manage the legacy of exploitation of nuclear power and use of radioactive materials. This paper describes work on-going to provide enhanced regulatory supervision of these activities as regards radiological protection. The scope includes worker and public protection in routine operation; emergency preparedness and response; radioactive waste management, including treatment, interim storage and transport as well as final disposal; and long term site restoration. Examples examined include waste from facilities in NW Russia, including remediation of previous shore technical bases (STBs) for submarines, spent fuel and radioactive waste management from ice-breakers, andmore » decommissioning of Radio-Thermal-Generators (RTGs) used in navigational devices. Consideration is given to the identification of regulatory responsibilities among different regulators; development of necessary regulatory instruments; and development of regulatory procedures for safety case reviews and compliance monitoring and international cooperation between different regulators. (authors)« less

  12. Remedy Selection and Land Use at Federal Facilities

    EPA Pesticide Factsheets

    Analysis of approximately 98 percent of the interim and final source control Records of Decision signed at Federal Facilities on the NPL from the beginning of Superfund through August 1995. PB96-963309. EPA/540/R-96/020. August 1996

  13. Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study.

    PubMed

    Arzimanoglou, Alexis; Ferreira, Jose A; Satlin, Andrew; Mendes, Shannon; Williams, Betsy; Critchley, David; Schuck, Edgar; Hussein, Ziad; Kumar, Dinesh; Dhadda, Shobha; Bibbiani, Francesco

    2016-05-01

    A good knowledge of safety and age group-specific pharmacokinetics (PK) of antiepileptic drugs (AEDs) in young pediatric patients is of great importance in clinical practice. This paper presents 6-month interim safety and PK from an ongoing 2-year open-label study (Study 303) of adjunctive rufinamide treatment in pediatric subjects ≥ 1 to < 4 years with inadequately controlled epilepsies of the Lennox-Gastaut syndrome (LGS) spectrum. Subjects (N = 37) were randomized to either rufinamide or any other approved AED chosen by the investigator as adjunctive therapy to the subject's existing regimen of 1-3 AEDs. Interim safety results showed that treatment-emergent adverse events (TEAEs) were similar between the rufinamide (22 [88.0%]) and any-other-AED group (9 [81.8%]), with most events considered mild or moderate. A population PK analysis was conducted including plasma rufinamide concentrations from Study 303 and two other study populations of LGS subjects ≥ 4 years. The rufinamide PK profile was dose independent. The apparent clearance (CL/F) estimated from the PK model was 2.19 L/h; it was found to increase significantly as a function of body weight. Coadministration of valproic acid significantly decreased rufinamide CL/F. CL/F was not significantly affected by other concomitant AEDs, age, gender, race, hepatic function, or renal function. No adjustments to body weight-based rufinamide dosing in subjects ≥ 1 to < 4 years are necessary. Rufinamide was safe and well tolerated in these pediatric subjects. Results from the interim analysis demonstrate that rufinamide's safety and PK profile is comparable in subjects ≥ 1 to < 4 and ≥ 4 years with LGS. Study 303 (clinicaltrials.gov: NCT01405053). Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. 77 FR 74512 - Interim Policy Leasing for Renewable Energy Data Collection Facility on the Outer Continental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Policy Leasing for Renewable Energy Data Collection Facility on the Outer Continental Shelf off the Coast..., tribes, local governments, and the public in the preparation of an EA. The EA will consider the environmental consequences associated with issuing a lease for an offshore data collection facility located on...

  15. Evaluation of automated flagger assistance devices : interim report.

    DOT National Transportation Integrated Search

    2017-08-01

    Flagger safety is an important issue in work zones due to the proximity of the flagger to traffic. Some strategies for improving flagger safety include slowing down approaching vehicles or removing flaggers from the immediate vicinity of traffic. The...

  16. 40 CFR 745.82 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... child-occupied facilities, except for the following: (1) Renovations in target housing or child-occupied...) Renovations in target housing or child-occupied facilities in which a certified renovator, using an EPA... with significant damage. Interim controls performed in response to an elevated blood lead level in a...

  17. INTERIM -- Starlink Software Environment

    NASA Astrophysics Data System (ADS)

    Pearce, Dave; Pavelin, Cliff; Lawden, M. D.

    Early versions of this paper were based on a number of other papers produced at a very early stage of the Starlink project. They contained a description of a specific implementation of a subroutine library, speculations on the desirable attributes of a software environment, and future development plans. They reflected the experimental nature of the Starlink software environment at that time. Since then, the situation has changed. The implemented subroutine library, INTERIM_DIR:INTERIM.OLB, is now a well established and widely used piece of software. A completely new Starlink software environment (ADAM) has been developed and distributed. Thus the library released in 1980 as `STARLINK' and now called `INTERIM' has reached the end of its development cycle and is now frozen in its current state, apart from bug corrections. This paper has, therefore, been completely rewritten and restructured to reflect the new situation. Its aim is to describe the facilities of the INTERIM subroutine library as clearly and concisely as possible. It avoids speculation, discussion of design decisions, and announcements of future plans.

  18. 76 FR 78150 - Procedures for the Handling of Retaliation Complaints Under Section 806 of the Sarbanes-Oxley Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... of the Sarbanes-Oxley Act of 2002, as Amended; Correction AGENCY: Occupational Safety and Health Administration, Labor. ACTION: Interim final rule; correction. SUMMARY: The Occupational Safety and Health... DEPARTMENT OF LABOR Occupational Safety and Health Administration 29 CFR Part 1980 [Docket Number...

  19. 14 CFR 171.263 - Localizer automatic monitor system.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

  20. 14 CFR 171.263 - Localizer automatic monitor system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

  1. 14 CFR 171.263 - Localizer automatic monitor system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

  2. 14 CFR 171.263 - Localizer automatic monitor system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

  3. 14 CFR 171.263 - Localizer automatic monitor system.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Interim Standard Microwave Landing... provide an automatic monitor system that transmits a warning to designated local and remote control points... centerline equivalent to more than 0.015 DDM at the ISMLS reference datum. (2) For localizers in which the...

  4. H. R. 3692: a bill to modify the deadlines applicable to hazardous waste disposal facilities. A report submitted to the House of Representatives, Ninety-Ninth Congress, First Session, November 6, 1985

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1985-01-01

    This bill amends the Solid Waste Disposal Act to change the deadlines when facilities must certify that they are in compliance with the financial requirements of the Act; i.e., that they have obtained appropriate insurance policies and other protection as required by law. The bill delays compliance during interim status in terms of groundwater monitoring, with interim status terminating on November 8, 1987. The bill covers facilities which were in compliance, but whose insurance policies were later cancelled, those with revenues in the July 1981-1982 fiscal year of less than $5 million, those in states whose requirement came into effectmore » after November 8, 1984, and those which can document a good-faith effort to comply.« less

  5. Planning for progress, productivity, and performance.

    PubMed

    Benedict, J M

    1983-10-01

    A project is described for the interim renovation of a labor intensive existing foodservice facility. The renovated area will provide effective food management during the hospital's redevelopment period, including a new foodservice. Objectives of the interim project were to conserve labor while emphasizing control and centralization, provide economic foodservices with improved quality, and incorporate one tray distribution system throughout the hospital complex. Immediate measures were necessary in order to generate funds to proceed. Renovations had to occur without disrupting food-service to patients. The project was planned over a three year period and included an ingredient control area, two patient tray service centres, a renewed production kitchen and test kitchen facility. Each phase has been financed on the understanding that the costs of construction and equipment will be repaid within one fiscal year of operating the renovated facility. Positive results are being achieved, attributable to the support and encouragement received from staff during the change process.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hopper, Calvin Mitchell

    In May 1973 the University of New Mexico conducted the first nationwide criticality safety training and education week-long short course for nuclear criticality safety engineers. Subsequent to that course, the Los Alamos Critical Experiments Facility (LACEF) developed very successful 'hands-on' subcritical and critical training programs for operators, supervisors, and engineering staff. Since the inception of the US Department of Energy (DOE) Nuclear Criticality Technology and Safety Project (NCT&SP) in 1983, the DOE has stimulated contractor facilities and laboratories to collaborate in the furthering of nuclear criticality as a discipline. That effort included the education and training of nuclear criticality safetymore » engineers (NCSEs). In 1985 a textbook was written that established a path toward formalizing education and training for NCSEs. Though the NCT&SP went through a brief hiatus from 1990 to 1992, other DOE-supported programs were evolving to the benefit of NCSE training and education. In 1993 the DOE established a Nuclear Criticality Safety Program (NCSP) and undertook a comprehensive development effort to expand the extant LACEF 'hands-on' course specifically for the education and training of NCSEs. That successful education and training was interrupted in 2006 for the closing of the LACEF and the accompanying movement of materials and critical experiment machines to the Nevada Test Site. Prior to that closing, the Lawrence Livermore National Laboratory (LLNL) was commissioned by the US DOE NCSP to establish an independent hands-on NCSE subcritical education and training course. The course provided an interim transition for the establishment of a reinvigorated and expanded two-week NCSE education and training program in 2011. The 2011 piloted two-week course was coordinated by the Oak Ridge National Laboratory (ORNL) and jointly conducted by the Los Alamos National Laboratory (LANL) classroom education and facility training, the Sandia National Laboratory (SNL) hands-on criticality experiments training, and the US DOE National Criticality Experiment Research Center (NCERC) hands-on criticality experiments training that is jointly supported by LLNL and LANL and located at the Nevada National Security Site (NNSS) This paper provides the description of the bases, content, and conduct of the piloted, and future US DOE NCSP Criticality Safety Engineer Training and Education Project.« less

  7. Spent Fuel Working Group Report. Volume 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    O`Toole, T.

    1993-11-01

    The Department of Energy is storing large amounts of spent nuclear fuel and other reactor irradiated nuclear materials (herein referred to as RINM). In the past, the Department reprocessed RINM to recover plutonium, tritium, and other isotopes. However, the Department has ceased or is phasing out reprocessing operations. As a consequence, Department facilities designed, constructed, and operated to store RINM for relatively short periods of time now store RINM, pending decisions on the disposition of these materials. The extended use of the facilities, combined with their known degradation and that of their stored materials, has led to uncertainties about safety.more » To ensure that extended storage is safe (i.e., that protection exists for workers, the public, and the environment), the conditions of these storage facilities had to be assessed. The compelling need for such an assessment led to the Secretary`s initiative on spent fuel, which is the subject of this report. This report comprises three volumes: Volume I; Summary Results of the Spent Fuel Working Group Evaluation; Volume II, Working Group Assessment Team Reports and Protocol; Volume III; Operating Contractor Site Team Reports. This volume presents the overall results of the Working Group`s Evaluation. The group assessed 66 facilities spread across 11 sites. It identified: (1) facilities that should be considered for priority attention. (2) programmatic issues to be considered in decision making about interim storage plans and (3) specific vulnerabilities for some of these facilities.« less

  8. 16 CFR 1209.31 - Purpose and applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1209.31 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS..., importers, and private labelers must follow to certify that their products comply with the Amended Interim... temporary household or residence, a school, in recreation or otherwise. The standard applies to cellulose...

  9. 16 CFR 1209.31 - Purpose and applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1209.31 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS..., importers, and private labelers must follow to certify that their products comply with the Amended Interim... temporary household or residence, a school, in recreation or otherwise. The standard applies to cellulose...

  10. 16 CFR 1209.31 - Purpose and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1209.31 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS..., importers, and private labelers must follow to certify that their products comply with the Amended Interim... temporary household or residence, a school, in recreation or otherwise. The standard applies to cellulose...

  11. 77 FR 4296 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Activities; Submission to OMB for Review and Approval; Comment Request; Facility Ground-Water Monitoring... docket, go to www.regulations.gov . Title: Facility Ground-Water Monitoring Requirements (Renewal). ICR.... Abstract: This ICR examines the ground-water monitoring standards for permitted and interim status...

  12. 42 CFR 412.432 - Method of payment under the inpatient psychiatric facility prospective payment system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR... inpatient psychiatric facility receives payment under this subpart for inpatient operating cost and capital-related costs for each inpatient stay following submission of a bill. (b) Periodic interim payments (PIP...

  13. Comparative risk assessments for the production and interim storage of glass and ceramic waste forms: Defense waste processing facility

    NASA Astrophysics Data System (ADS)

    Huang, J. C.; Wright, W. V.

    1982-04-01

    The Defense Waste Processing Facility (DWPF) for immobilizing nuclear high level waste (HLW) is scheduled to be built. High level waste is produced when reactor components are subjected to chemical separation operations. Two candidates for immobilizing this HLW are borosilicate glass and crystalline ceramic, either being contained in weld sealed stainless steel canisters. A number of technical analyses are being conducted to support a selection between these two waste forms. The risks associated with the manufacture and interim storage of these two forms in the DWPF are compared. Process information used in the risk analysis was taken primarily from a DWPF processibility analysis. The DWPF environmental analysis provided much of the necessary environmental information.

  14. PROJECT W-551 DETERMINATION DATA FOR EARLY LAW INTERIM PRETREATMENT SYSTEM SELECTION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    TEDESCHI AR

    This report provides the detailed assessment forms and data for selection of the solids separation and cesium separation technology for project W-551, Interim Pretreatment System. This project will provide early pretreated low activity waste feed to the Waste Treatment Plant to allow Waste Treatment Plan Low Activity Waste facility operation prior to construction completion of the Pretreatment and High Level Waste facilities. The candidate solids separations technologies are rotary microfiltration and crossflow filtration, and the candidate cesium separation technologies are fractional crystallization, caustic-side solvent extraction, and ion-exchange using spherical resorcinol-formaldehyde resin. This data was used to prepare a cross-cutting technologymore » summary, reported in RPP-RPT-37740.« less

  15. Interim Analysis of School Facility Funding in the American Recovery and Reinvestment Act of 2009 Including Expenditures through January 5, 2010

    ERIC Educational Resources Information Center

    21st Century School Fund, 2010

    2010-01-01

    The 21st Century School Fund, through its Building Educational Success Together (BEST) collaborative, is tracking the effect of federal stimulus funding on the condition of PK-12 public school facilities and whether or not the distribution of ARRA funding related to public school facilities is helping reduce the disparity of capital expenditures…

  16. Effectiveness of Low Temperature Additives for Biodiesel Blends

    DTIC Science & Technology

    2012-06-30

    Westbrook U.S. Army TARDEC Fuels and Lubricants Research Facility Southwest Research Institute® (SwRI®) San Antonio, TX for U.S. Army TARDEC...INTERIM REPORT TFLRF No. 428 by Steven R. Westbrook U.S. Army TARDEC Fuels and Lubricants Research Facility Southwest Research Institute...Director U.S. Army TARDEC Fuels and Lubricants Research Facility (SwRI®) UNCLASSIFIED UNCLASSIFIED REPORT DOCUMENTATION PAGE Form Approved

  17. Neutron detection devices with 6LiF converter layers

    NASA Astrophysics Data System (ADS)

    Finocchiaro, Paolo; Cosentino, Luigi; Meo, Sergio Lo; Nolte, Ralf; Radeck, Desiree

    2018-01-01

    The demand for new thermal neutron detectors as an alternative to 3He tubes in research, industrial, safety and homeland security applications, is growing. These needs have triggered research and development activities about new generations of thermal neutron detectors, characterized by reasonable efficiency and gamma rejection comparable to 3He tubes. In this paper we show the state of art of a promising lowcost technique, based on commercial solid state silicon detectors coupled with thin neutron converter layers of 6LiF deposited onto carbon fiber substrates. Several configurations were studied with the GEANT4 simulation code, and then calibrated at the PTB Thermal Neutron Calibration Facility. The results show that the measured detection efficiency is well reproduced by the simulations, therefore validating the simulation tool in view of new designs. These neutron detectors have also been tested at neutron beam facilities like ISIS (Rutherford Appleton Laboratory, UK) and n_TOF (CERN) where a few samples are already in operation for beam flux and 2D profile measurements. Forthcoming applications are foreseen for the online monitoring of spent nuclear fuel casks in interim storage sites.

  18. Safety and Security of Radioactive Sealed and Disused/Orphan Sources in Ukraine - German Contribution - 13359

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brasser, Thomas; Hertes, Uwe; Meyer, Thorsten

    2013-07-01

    Within the scope of 'Nuclear Security of Radioactive Sources', the German government implemented the modernization of Ukrainian State Production Company's transport and storage facility for radioactive sources (TSF) in Kiev. The overall management of optimizing the physical protection of the storage facility (including the construction of a hot cell for handling the radioactive sources) is currently carried out by the German Federal Foreign Office (AA). AA jointly have assigned Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Germany's leading expert institution in the area of nuclear safety and waste management, to implement the project and to ensure transparency by financial andmore » technical monitoring. Sealed radioactive sources are widely used in industry, medicine and research. Their life cycle starts with the production and finally ends with the interim/long-term storage of the disused sources. In Ukraine, IZOTOP is responsible for all radioactive sources throughout their life cycle. IZOTOP's transport and storage facility (TSF) is the only Ukrainian storage facility for factory-fresh radioactive sources up to an activity of about 1 million Ci (3.7 1016 Bq). The TSF is specially designed for the storage and handling of radioactive sources. Storage began in 1968, and is licensed by the Ukrainian state authorities. Beside the outdated state of TSF's physical protection and the vulnerability of the facility linked with it, the lack of a hot cell for handling and repacking radioactive sources on the site itself represents an additional potential hazard. The project, financed by the German Federal Foreign Office, aims to significantly improve the security of radioactive sources during their storage and handling at the TSF site. Main tasks of the project are a) the modernization of the physical protection of the TSF itself in order to prevent any unauthorized access to radioactive sources as well as b) the construction of a hot cell to reduce the number of transports of radioactive sources within the city of Kiev. In future, the new established hot cell at IZOTOP's transport and storage facility will be useful for identification and characterization of orphan/disused radioactive sources. The projects implemented are performed in accordance with international recommendations (e. g. IAEA) and national normative documents and will make a crucial contribution towards an improved safety and security management of radioactive sources in Ukraine. (authors)« less

  19. NASA Safety and Health (Short Form). Final rule

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This final rule adopts with changes the interim rule published in the Federal Register on April 5, 2001 (65 FR 18051-18053), which amended the NASA FAR Supplement to implement a Safety and Health (Short Form) clause to address safety and occupational health in all NASA contracts above the micro-purchase threshold where the existing Safety and Health clause did not apply, and amended other safety and health clauses to be consistent with the new NASA Safety and Health (Short Form) clause.

  20. Safety and efficacy of long-term treatment with teneligliptin: Interim analysis of a post-marketing surveillance of more than 10,000 Japanese patients with type 2 diabetes mellitus.

    PubMed

    Kadowaki, Takashi; Haneda, Masakazu; Ito, Hiroshi; Ueno, Makoto; Matsukawa, Miyuki; Yamakura, Tomoko; Sasaki, Kazuyo; Kimura, Mayumi; Iijima, Hiroaki

    2018-02-01

    This post-marketing surveillance examined the safety and efficacy of long-term teneligliptin therapy in Japanese patients. We report interim results (cut-off date: 28 June 2017) of a 3-year PMS undertaken in subjects with type 2 diabetes mellitus (T2DM). Survey items included demographics, treatments, adverse drug reactions (ADRs), and laboratory variables. A subgroup analysis was also performed across three age groups (<65 years; 65 to <75 years; ≥75 years). Main outcome measures were incidence of ADRs, laboratory variables, and change in glycated hemoglobin (HbA1c) from baseline over time. Of 11,677 patients registered, data from 10,532 patients (6,338 males/4,194 females) were analyzed for the safety analysis set; the median administration period was 731 days. Overall, ADRs and serious ADRs were reported in 364 (3.46%) and 91 patients (0.86%), respectively. The most common ADRs were all hypoglycemia (0.32%), constipation (0.27%), and hepatic function abnormal (0.24%). No change in mean body weight occurred, and a reduction in mean HbA1c was observed until 2 years. The safety and efficacy profiles did not differ markedly among the three age groups. These interim results show that teneligliptin was well tolerated and improved hyperglycemia in Japanese patients with T2DM in clinical practice.

  1. Safety Effectiveness of Regulatory Headlight Signs in Wyoming - Phase 1 : Interim Report - Phase 2

    DOT National Transportation Integrated Search

    2016-01-01

    Although Daytime Running Lights (DRLs) may have a significant impact on increasing vehicle conspicuity during different times of the day, their effect on overall safety is still up for debate. A recent study by the U.S. Department of Transportation (...

  2. Treatment of G1 Baskets at the CEA Marcoule Site - 12027

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fourquet, Line; Boya, Didier

    2012-07-01

    In the dismantling program for the first-generation French reactors in accordance with the nonproliferation treaty, the CEA is in charge of cleanup and dismantling operations for the facilities at Marcoule, including the decladding units. The G1 decladding was built between 1955 and 1957 in order to de-clad spent fuel elements from the G1 plutonium-producing reactor and prepare them for dissolution. The facility was also used for interim storage of G1, G2 and G3 fuel dissolution baskets, which had been used during plant operation for transfer (from the decladding facility to the UP1 plant) and/or dissolution of spent fuel elements. Onemore » of the cleanup projects involves recovery of the baskets, which will be cut up, sorted, and conditioned in metal bins. The bins will be immobilized with cement grout, then transferred to the onsite solid waste conditioning facility (CDS) and to the repository operated by the French National Radioactive Waste Management Agency (ANDRA). The project is now in progress, after special safety permits were issued and measurement stations and dedicated tools were developed to handle all types of baskets (which differed according to their origin and use). The disposal of all the baskets is scheduled to last 2 years and will produce 55 metal waste bins. (authors)« less

  3. RCRA, superfund and EPCRA hotline training module. Introduction to: Permits and interim status (40 cfr part 270) updated July 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-07-01

    Owners/operators of facilities that treat, store, or dispose of hazardous waste must obtain an operating permit, as required by Subtitle C of the Resource Conservation and Recovery Act (RCRA). The module presents an overview of the RCRA permitting process and the requirements that apply to TSDFs operating under interim status until a permit is issued. The regulations governing the permit process are found in 40 CFR Parts 124 through 270.

  4. 76 FR 72559 - Enhancements to Emergency Preparedness Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... allow the assignment of the on-shift health physics technician (HP Tech.) as the interim operations... public health and safety. These modifications were issued to licensees by NRC Order EA-02-026, ``Order... health and safety through improvements in the response to unlikely initiating events that could lead to...

  5. 16 CFR 1209.8 - Procedure for calibration of radiation instrumentation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.8 Procedure... radiation pyrometer. Repeat for each temperature. (b) Total heat flux meter. The total flux meter shall be... meter. This latter calibration shall make use of the radiant panel tester as the heat source...

  6. 16 CFR 1209.8 - Procedure for calibration of radiation instrumentation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.8 Procedure... radiation pyrometer. Repeat for each temperature. (b) Total heat flux meter. The total flux meter shall be... meter. This latter calibration shall make use of the radiant panel tester as the heat source...

  7. 10 CFR Appendix A to Part 440 - Standards for Weatherization Materials

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...] Insulate tank and distribution piping (See insulation section of this appendix). Install heat traps on..., Ceilings, Attics, and Roofs Insulation—organic fiber—conformance to Interim Safety Standard in 16 CFR part 1209; Fire Safety Requirements for Thermal Insulating Materials According to Insulation Use—Attic Floor...

  8. 10 CFR Appendix A to Part 440 - Standards for Weatherization Materials

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...] Insulate tank and distribution piping (See insulation section of this appendix). Install heat traps on..., Ceilings, Attics, and Roofs Insulation—organic fiber—conformance to Interim Safety Standard in 16 CFR part 1209; Fire Safety Requirements for Thermal Insulating Materials According to Insulation Use—Attic Floor...

  9. 10 CFR Appendix A to Part 440 - Standards for Weatherization Materials

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...] Insulate tank and distribution piping (See insulation section of this appendix). Install heat traps on..., Ceilings, Attics, and Roofs Insulation—organic fiber—conformance to Interim Safety Standard in 16 CFR part 1209; Fire Safety Requirements for Thermal Insulating Materials According to Insulation Use—Attic Floor...

  10. 16 CFR 1209.8 - Procedure for calibration of radiation instrumentation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.8 Procedure... radiation pyrometer. Repeat for each temperature. (b) Total heat flux meter. The total flux meter shall be... meter. This latter calibration shall make use of the radiant panel tester as the heat source...

  11. 10 CFR Appendix A to Part 440 - Standards for Weatherization Materials

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...] Insulate tank and distribution piping (See insulation section of this appendix). Install heat traps on..., Ceilings, Attics, and Roofs Insulation—organic fiber—conformance to Interim Safety Standard in 16 CFR part 1209; Fire Safety Requirements for Thermal Insulating Materials According to Insulation Use—Attic Floor...

  12. 16 CFR 1209.8 - Procedure for calibration of radiation instrumentation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.8 Procedure... radiation pyrometer. Repeat for each temperature. (b) Total heat flux meter. The total flux meter shall be... meter. This latter calibration shall make use of the radiant panel tester as the heat source...

  13. 78 FR 49735 - Intent To Prepare a Draft Environmental Impact Statement for Dam Safety Study, Lake Lewisville...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ... determine appropriate permanent methods for correcting potential problems, interim risk reduction measures... Environmental Impact Statement for Dam Safety Study, Lake Lewisville Dam, Elm Fork Trinity River, Denton County... primary purposes of the project are flood risk management, [[Page 49736

  14. Interim Status Closure Plan Open Burning Treatment Unit Technical Area 16-399 Burn Tray

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vigil-Holterman, Luciana R.

    2012-05-07

    This closure plan describes the activities necessary to close one of the interim status hazardous waste open burning treatment units at Technical Area (TA) 16 at the Los Alamos National Laboratory (LANL or the Facility), hereinafter referred to as the 'TA-16-399 Burn Tray' or 'the unit'. The information provided in this closure plan addresses the closure requirements specified in the Code of Federal Regulations (CFR), Title 40, Part 265, Subparts G and P for the thermal treatment units operated at the Facility under the Resource Conservation and Recovery Act (RCRA) and the New Mexico Hazardous Waste Act. Closure of themore » open burning treatment unit will be completed in accordance with Section 4.1 of this closure plan.« less

  15. Characterization of neutron sources from spent fuel casks. [Skyshine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parks, C.V.; Pace, J.V. III

    1987-01-01

    In the interim period prior to the acceptance of spent fuel for disposal by the USDOE, utilities are beginning to choose dry cask storage as an alternative to pool re-racking, transshipments, or new pool construction. In addition, the current MRS proposal calls for interim dry storage of consolidated spent fuel in concrete casks. As part of the licensing requirements for these cask storage facilities, calculations are typically necessary to determine the yearly radiation dose received at the site boundary. Unlike wet facilities, neutron skyshine can be an important contribution to the total boundary dose from a dry storage facility. Calculationmore » of the neutron skyshine is in turn heavily dependent on the source characteristics and source model selected for the analysis. This paper presents the basic source characteristics of the spent fuel stored in dry casks and discusses factors that must be considered in evaluating and modeling the radiation sources for the subsequent skyshine calculation. 4 refs., 1 tab.« less

  16. 16 CFR Figure 5 to Subpart A of... - Zero Reference Point Related to Detecting Plane

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Zero Reference Point Related to Detecting Plane 5 Figure 5 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 5 Figure 5 to Subpart A o...

  17. 16 CFR Figure 10 to Subpart A of... - Insulation Radiant Panel Test Data Log Format

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A...

  18. 16 CFR Figure 10 to Subpart A of... - Insulation Radiant Panel Test Data Log Format

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A...

  19. 16 CFR Figure 10 to Subpart A of... - Insulation Radiant Panel Test Data Log Format

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A...

  20. 16 CFR Figure 10 to Subpart A of... - Insulation Radiant Panel Test Data Log Format

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A...

  1. 16 CFR Figure 10 to Subpart A of... - Insulation Radiant Panel Test Data Log Format

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A...

  2. A Guide for Planning Facilities for Occupational Preparation Programs in Metallurgy Technology. Interim Report. Research 28.

    ERIC Educational Resources Information Center

    German, Carl, Jr.

    The major purpose of this guide is to elicit the information necessary for writing educational specifications for facilities to house technical education programs in metallurgy. It is organized in these parts: (1) Part I discusses the major purpose, underlying assumptions, recent instructional trends, and guiding principles utilized in the…

  3. 42 CFR 412.624 - Methodology for calculating the Federal prospective payment rates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Adjustments for teaching hospitals. For discharges on or after October 1, 2005, CMS adjusts the Federal prospective payment on a facility basis by a factor as specified by CMS for facilities that are teaching institutions or units of teaching institutions. This adjustment is made on a claim basis as an interim payment...

  4. Safety Analysis of Dual Purpose Metal Cask Subjected to Impulsive Loads due to Aircraft Engine Crash

    NASA Astrophysics Data System (ADS)

    Shirai, Koji; Namba, Kosuke; Saegusa, Toshiari

    In Japan, the first Interim Storage Facility of spent nuclear fuel away from reactor site is being planned to start its commercial operation around 2010, in use of dual-purpose metal cask in the northern part of Main Japan Island. Business License Examination for safety design approval has started since March, 2007. To demonstrate the more scientific and rational performance of safety regulation activities on each phase for the first license procedure, CREPEI has executed demonstration tests with full scale casks, such as drop tests onto real targets without impact limiters(1) and seismic tests subjected to strong earthquake motions(2). Moreover, it is important to develop the knowledge for the inherent security of metal casks under extreme mechanical-impact conditions, especially for increasing interest since the terrorist attacks from 11th September 2001(3)-(6). This paper presents dynamic mechanical behavior of the metal cask lid closure system caused by direct aircraft engine crash and describes calculated results (especially, leak tightness based on relative dynamic displacements between metallic seals). Firstly, the local penetration damage of the interim storage facility building by a big passenger aircraft engine crash (diameter 2.7m, length 4.3m, weight 4.4ton, impact velocity 90m/s) has been examined. The reduced velocity is calculated by the local damage formula for concrete structure with its thickness of 70cm. The load vs. time function for this reduced velocity (60m/s) is estimated by the impact analysis using Finite Element code LS-DYNA with the full scale engine model onto a hypothetically rigid target. Secondly, as the most critical scenarios for the metal cask, two impact scenarios (horizontal impact hitting the cask and vertical impact onto the lid metallic seal system) are chosen. To consider the geometry of all bolts for two lids, the gasket reaction forces and the inner pressure of the cask cavity, the detailed three dimensional FEM models are developed and calculated. Main criteria for estimating the maximum leakage rate for the lid metallic seal system are no loss of the pre-stress of the lid bolts, no appearance of the plastic region between the metal seal flanges, and no large relative deformation of the lid seals. Finally, in both cases, the low leakage rate for the metal cask lid closure system under the impulsive loads due to aircraft engine crash will be proved thoroughly.

  5. 16 CFR § 1209.6 - Test procedures for critical radiant flux.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... radiant flux of exposed attic floor insulation using a radiant heat energy source. (a) Apparatus and... SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.6 Test... radiant heat energy panel or equivalent panel inclined at 30° above and directed at a horizontally-mounted...

  6. 16 CFR § 1209.8 - Procedure for calibration of radiation instrumentation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.8... radiation pyrometer. Repeat for each temperature. (b) Total heat flux meter. The total flux meter shall be... meter. This latter calibration shall make use of the radiant panel tester as the heat source...

  7. Software Safety Progress in NASA

    NASA Technical Reports Server (NTRS)

    Radley, Charles F.

    1995-01-01

    NASA has developed guidelines for development and analysis of safety-critical software. These guidelines have been documented in a Guidebook for Safety Critical Software Development and Analysis. The guidelines represent a practical 'how to' approach, to assist software developers and safety analysts in cost effective methods for software safety. They provide guidance in the implementation of the recent NASA Software Safety Standard NSS-1740.13 which was released as 'Interim' version in June 1994, scheduled for formal adoption late 1995. This paper is a survey of the methods in general use, resulting in the NASA guidelines for safety critical software development and analysis.

  8. A Guide for Planning Facilities for Occupational Preparation Programs in Data Processing. Interim Report. Research 25.

    ERIC Educational Resources Information Center

    McIntosh, William A.

    This guide lists a series of pivotal questions about the educational program to be offered, and the answers to these questions bear directly on the numbers and kinds of instructional areas needed in the contemplated facilities. Much of the material is presented in a checklist format which allows for consideration of alternatives in facility…

  9. A Guide for Planning Facilities for Occupational Preparation Programs in the Machine Trades. Interim Report. Research 24.

    ERIC Educational Resources Information Center

    Larson, Milton E.

    This guide is designed for use by any person or groups of persons responsible for planning occupational programs in the machine trades. Its major purpose is to elicit the necessary information for the writing of educational specifications for facilities to house needed vocational programs in machine tool operation, machine shop, and tool and die…

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This volume contains the interim change notice for the safety operation procedure for hot cell. It covers the master-slave manipulators, dry waste removal, cell transfers, hoists, cask handling, liquid waste system, and physical characterization of fluids.

  11. Absolute efficiency calibration of 6LiF-based solid state thermal neutron detectors

    NASA Astrophysics Data System (ADS)

    Finocchiaro, Paolo; Cosentino, Luigi; Lo Meo, Sergio; Nolte, Ralf; Radeck, Desiree

    2018-03-01

    The demand for new thermal neutron detectors as an alternative to 3He tubes in research, industrial, safety and homeland security applications, is growing. These needs have triggered research and development activities about new generations of thermal neutron detectors, characterized by reasonable efficiency and gamma rejection comparable to 3He tubes. In this paper we show the state of the art of a promising low-cost technique, based on commercial solid state silicon detectors coupled with thin neutron converter layers of 6LiF deposited onto carbon fiber substrates. A few configurations were studied with the GEANT4 simulation code, and the intrinsic efficiency of the corresponding detectors was calibrated at the PTB Thermal Neutron Calibration Facility. The results show that the measured intrinsic detection efficiency is well reproduced by the simulations, therefore validating the simulation tool in view of new designs. These neutron detectors have also been tested at neutron beam facilities like ISIS (Rutherford Appleton Laboratory, UK) and n_TOF (CERN) where a few samples are already in operation for beam flux and 2D profile measurements. Forthcoming applications are foreseen for the online monitoring of spent nuclear fuel casks in interim storage sites.

  12. The WIND-HAARP-HIPAS Interferometer Experiment

    DTIC Science & Technology

    1999-04-22

    Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6750--99-8349 The WIND- HAARP -HIPAS Interferometer Experiment P. RODRIGUEZ AND M. J...1999 3. REPORT TYPE AND DATES COVERED Interim Report 4. TITLE AND SUBTITLE The WIND- HAARP -HIPAS Interferometer Experiment 5. FUNDING NUMBERS JO...frequency transmitting facilities in a bistatic, interferometer mode. The HAARP and HIPAS facilities in Alaska radiated at 4525 kHz with total combined

  13. SPACE COMMUNICATIONS TECHNIQUES

    DTIC Science & Technology

    A description is given of the expansion of interim simplex space communication facilities at Rome, N . Y ., and Trinidad to full duplex for use in...communications baseband demod ulator, doppler-shift tracking, and passive radar tracking at Rome, N . Y . are discussed.

  14. Pembrolizumab for Ipilimumab-Resistant Melanoma

    Cancer.gov

    KEYNOTE-002 was designed to test the safety and efficacy of two doses of pembrolizumab compared with chemotherapy in patients with ipilimumab-resistant melanoma; interim results show that pembrolizumab improves progression-free survival for these patients

  15. Baseline characteristics and interim (3-month) efficacy and safety data from STELLA-LONG TERM, a long-term post-marketing surveillance study of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice.

    PubMed

    Maegawa, Hiroshi; Tobe, Kazuyuki; Tabuchi, Hiromi; Nakamura, Ichiro

    2016-10-01

    To evaluate the efficacy and safety of ipragliflozin in real-world clinical practice in Japanese patients with type 2 diabetes. We conducted interim analyses at 3 months of a 3-year prospective study of patients who were first prescribed ipragliflozin between 17 July 2014 and 16 October 2015, and whose data were locked by 16 January 2016. Changes in glycemic control, blood pressure, and laboratory variables from baseline, and incidence of adverse drug reactions (ADRs). Of 11,412 patients initially registered, efficacy and safety data were available for 3481 (30.5%) and 4360 (38.2%) patients, respectively. Hemoglobin A1c and fasting plasma glucose decreased by 0.67% and 28.8 mg/dL, respectively, at 3 months/last assessment (both P < .001) from baseline (8.00% and 166.4 mg/dL, respectively). Blood pressure and lipid levels also improved significantly. There were 258 ADRs in 194 patients. The ADRs included 'renal and urinary disorders' (system organ class) in 110 patients (2.5%). These 3-month interim results indicate that ipragliflozin improved glycemic control, lipids, and blood pressure with low rates of ADRs in Japanese patients with type 2 diabetes in real-world clinical practice. The results were consistent with those of placebo-controlled, randomized clinical trials. Clinicaltrials.gov identifier: NCT02479399.

  16. Flight Set 360T004 (STS-30) Insulation Component, Interim Release, Volume 3

    NASA Technical Reports Server (NTRS)

    Passman, James A.

    1989-01-01

    The insulation component of the Redesigned Solid Rocket Motor (RSRM) is discussed. The results of all visual evaluations and a thermal safety factor analysis are given. The data contained here supersedes the interim release and the insulation data presented in the Clearfield 10 day report. The objective is to document the postflight condition of the internal and external insulation of nozzle to case joints, the case field joints, the igniter to case joints, and the acreage insulation which made up RSRM-4A and RSRM-4B.

  17. Soyuz-TM-based interim Assured Crew Return Vehicle (ACRV) for the Space Station Freedom

    NASA Technical Reports Server (NTRS)

    Semenov, Yu. P.; Babkov, Oleg I.; Timchenko, Vladimir A.; Craig, Jerry W.

    1993-01-01

    The concept of using the available Soyuz-TM Assured Crew Return Vehicle (ACRV) spacecraft for the assurance of the safety of the Space Station Freedom (SSF) crew after the departure of the Space Shuttle from SSF was proposed by the NPO Energia and was accepted by NASA in 1992. The ACRV will provide the crew with the capability to evacuate a seriously injured/ill crewmember from the SSF to a ground-based care facility under medically tolerable conditions and with the capability for a safe evacuation from SSF in the events SSF becomes uninhabitable or the Space Shuttle flights are interrupted for a time that exceeds SSF ability for crew support and/or safe operations. This paper presents the main results of studies on Phase A (including studies on the service life of ACRV; spacecraft design and operations; prelaunch processing; mission support; safety, reliability, maintenance and quality and assurance; landing, and search/rescue operations; interfaces with the SSF and with Space Shuttle; crew accommodation; motion of orbital an service modules; and ACRV injection by the Expendable Launch Vehicles), along with the objectives of further work on the Phase B.

  18. Operational Strategies for Low-Level Radioactive Waste Disposal Site in Egypt - 13513

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mohamed, Yasser T.

    The ultimate aims of treatment and conditioning is to prepare waste for disposal by ensuring that the waste will meet the waste acceptance criteria of a disposal facility. Hence the purpose of low-level waste disposal is to isolate the waste from both people and the environment. The radioactive particles in low-level waste emit the same types of radiation that everyone receives from nature. Most low-level waste fades away to natural background levels of radioactivity in months or years. Virtually all of it diminishes to natural levels in less than 300 years. In Egypt, The Hot Laboratories and Waste Management Centermore » has been established since 1983, as a waste management facility for LLW and ILW and the disposal site licensed for preoperational in 2005. The site accepts the low level waste generated on site and off site and unwanted radioactive sealed sources with half-life less than 30 years for disposal and all types of sources for interim storage prior to the final disposal. Operational requirements at the low-level (LLRW) disposal site are listed in the National Center for Nuclear Safety and Radiation Control NCNSRC guidelines. Additional procedures are listed in the Low-Level Radioactive Waste Disposal Facility Standards Manual. The following describes the current operations at the LLRW disposal site. (authors)« less

  19. Planning for the recreational end use of a future LLR waste mound in Canada - Leaving an honourable legacy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kleb, H.R.; Zelmer, R.L.

    2007-07-01

    The Low-Level Radioactive Waste Management Office was established in 1982 to carry out the federal government's responsibilities for low-level radioactive (LLR) waste management in Canada. In this capacity, the Office operates programs to characterize, delineate, decontaminate and consolidate historic LLR waste for interim and long-term storage. The Office is currently the proponent of the Port Hope Area Initiative; a program directed at the development and implementation of a safe, local long-term management solution for historic LLR waste in the Port Hope area. A legal agreement between the Government of Canada and the host community provides the framework for the implementationmore » of the Port Hope Project. Specifically, the agreement requires that the surface of the long-term LLR waste management facility be 'conducive to passive and active recreational uses such as soccer fields and baseball diamonds'. However, there are currently no examples of licensed LLR waste management facilities in Canada that permit recreational use. Such an end use presents challenges with respect to engineering and design, health and safety and landscape planning. This paper presents the cover system design, the environmental effects assessment and the landscape planning processes that were undertaken in support of the recreational end use of the Port Hope long-term LLR waste management facility. (authors)« less

  20. 16 CFR Figure 8 to Subpart A of... - Standard Radiant Heat Energy Flux Profile

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Standard Radiant Heat Energy Flux Profile 8... PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 8 Figure 8 to Subpart A of Part 1209—Standard Radiant Heat Energy Flux Profile EC03OC91...

  1. 16 CFR Figure 8 to Subpart A of... - Standard Radiant Heat Energy Flux Profile

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Standard Radiant Heat Energy Flux Profile 8... PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 8 Figure 8 to Subpart A of Part 1209—Standard Radiant Heat Energy Flux Profile EC03OC91...

  2. 16 CFR Figure 8 to Subpart A of... - Standard Radiant Heat Energy Flux Profile

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Standard Radiant Heat Energy Flux Profile 8... PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 8 Figure 8 to Subpart A of Part 1209—Standard Radiant Heat Energy Flux Profile EC03OC91...

  3. 16 CFR Figure 8 to Subpart A of... - Standard Radiant Heat Energy Flux Profile

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Standard Radiant Heat Energy Flux Profile 8... PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 8 Figure 8 to Subpart A of Part 1209—Standard Radiant Heat Energy Flux Profile EC03OC91...

  4. 16 CFR Figure 8 to Subpart A of... - Standard Radiant Heat Energy Flux Profile

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Standard Radiant Heat Energy Flux Profile 8... PRODUCT SAFETY ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard Pt. 1209, Subpt. A, Fig. 8 Figure 8 to Subpart A of Part 1209—Standard Radiant Heat Energy Flux Profile EC03OC91...

  5. 76 FR 63676 - Final Division of Safety Systems Interim Staff Guidance DSS-ISG-2010-01: Staff Guidance Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... learned based on recent submittals. FOR FURTHER INFORMATION CONTACT: Mr. Kent Wood, Division of Safety...-0001; telephone: 301-415-4120; or e- mail: [email protected] . ADDRESSES: You can access publicly... are available online in the NRC Library at http://www.nrc.gov/reading-rm/adams.html . From this page...

  6. Interim Cryogenic Propulsion Stage (ICPS) Transport from DOC to

    NASA Image and Video Library

    2017-07-26

    Packed inside its canister, the Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket arrives at the low bay entrance of the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  7. Interim Cryogenic Propulsion Stage (ICPS) Transport from DOC to

    NASA Image and Video Library

    2017-07-26

    Packed inside its canister, the Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket is being transported to the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  8. Interim Cryogenic Propulsion Stage (ICPS) Transport from DOC to

    NASA Image and Video Library

    2017-07-26

    Packed inside its canister, the Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket is moved into the low bay entrance of the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  9. 40 CFR 265.110 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Closure... through 265.115 (which concern closure) apply to the owners and operators of all hazardous waste...

  10. Estimates of Urban Roadway Congestion, 1990: Interim Report

    DOT National Transportation Integrated Search

    1993-03-01

    This research report is the fifth year continuation of a six year research effort focused on quantifying urban mobility. This study contains the facility information for 50 urban areas throughout the country. The database used for this research conta...

  11. Standards to prevent, detect, and respond to sexual abuse and sexual harassment involving unaccompanied children. Interim final rule (IFR).

    PubMed

    2014-12-24

    This IFR proposes standards and procedures to prevent, detect, and respond to sexual abuse and sexual harassment involving unaccompanied children (UCs) in ORR's care provider facilities. DATES: This IFR is effective on December 24, 2014. ORR care provider facilities must be in compliance with this IFR by June 24, 2015 but encourages care provider facilities to be in compliance sooner, if possible. HHS will work with facilities to implement and enforce the standards contained in this rule. Comments on this IFR must be received on or before February 23, 2015.

  12. LEVERAGING AGING MATERIALS DATA TO SUPPORT EXTENSION OF TRANSPORTATION SHIPPING PACKAGES SERVICE LIFE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dunn, K.; Bellamy, S.; Daugherty, W.

    Nuclear material inventories are increasingly being transferred to interim storage locations where they may reside for extended periods of time. Use of a shipping package to store nuclear materials after the transfer has become more common for a variety of reasons. Shipping packages are robust and have a qualified pedigree for performance in normal operation and accident conditions but are only certified over an approved transportation window. The continued use of shipping packages to contain nuclear material during interim storage will result in reduced overall costs and reduced exposure to workers. However, the shipping package materials of construction must maintainmore » integrity as specified by the safety basis of the storage facility throughout the storage period, which is typically well beyond the certified transportation window. In many ways, the certification processes required for interim storage of nuclear materials in shipping packages is similar to life extension programs required for dry cask storage systems for commercial nuclear fuels. The storage of spent nuclear fuel in dry cask storage systems is federally-regulated, and over 1500 individual dry casks have been in successful service up to 20 years in the US. The uncertainty in final disposition will likely require extended storage of this fuel well beyond initial license periods and perhaps multiple re-licenses may be needed. Thus, both the shipping packages and the dry cask storage systems require materials integrity assessments and assurance of continued satisfactory materials performance over times not considered in the original evaluation processes. Test programs for the shipping packages have been established to obtain aging data on materials of construction to demonstrate continued system integrity. The collective data may be coupled with similar data for the dry cask storage systems and used to support extending the service life of shipping packages in both transportation and storage.« less

  13. Metropolitan Spokane Region Water Resources Study. Appendix 1. Institutional Analysis

    DTIC Science & Technology

    1976-01-01

    projects in the State of Washington. -It- h"Ithe- ath- -ority to require compliance from all local... projects of relatively modest scope. -rojec- financ- ing is based, as in the case of irrigation districts, on assessments lev- ied on district lands. The ...treatment -facilities would be phased out at that time. The other interim facilities all west of Five Mile Prairie are projected to remain in service

  14. 40 CFR 265.340 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES... hazardous waste incinerators (as defined in § 260.10 of this chapter), except as § 265.1 provides otherwise...

  15. 40 CFR 265.340 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES... hazardous waste incinerators (as defined in § 260.10 of this chapter), except as § 265.1 provides otherwise...

  16. Road weather connected vehicle applications : benefit-cost analysis interim report.

    DOT National Transportation Integrated Search

    2013-01-01

    RWMP is currently engaged in a project to evaluate the potential benefits of road weather connected vehicle applications. Of particular interest are the potential improvements in safety, reductions in travel time, improved travel reliability, reducti...

  17. An investigation of safety belt usage and effectiveness

    DOT National Transportation Integrated Search

    1975-03-01

    This interim report contains primarily a theoretical discussion of problems of inference in studies on seat belt utilization and effectiveness. Seat belt effectiveness in accidents is initially discussed from a population paramenter point of, view. T...

  18. 33 CFR 96.350 - Interim Document of Compliance certificate: what is it and when can it be used?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Document of Compliance certificate may be issued to help set up a company's safety management system when— (1) A company is newly set up or in transition from an existing company into a new company; or (2) A new type of vessel is added to an existing safety management system and Document of Compliance...

  19. 40 CFR 265.31 - Maintenance and operation of facility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water which could threaten human health or the -environment. ...

  20. 40 CFR 265.31 - Maintenance and operation of facility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water which could threaten human health or the -environment. ...

  1. 40 CFR 265.31 - Maintenance and operation of facility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water which could threaten human health or the -environment. ...

  2. IFR Approval of Differential Global Positioning System (DGPS) Special Category I Instrument Approaches Using Private Ground Facilities

    DOT National Transportation Integrated Search

    1994-08-19

    This order establishes interim procedures to approve special instrument approach : operations using privately owned DGPS installations at U.S. and foreign airports/ : runways. It identifies specific criteria, not presently found in existing : standar...

  3. 40 CFR 265.31 - Maintenance and operation of facility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT... any unplanned sudden or non-sudden release of hazardous waste or hazardous waste constituents to air, soil, or surface water which could threaten human health or the -environment. ...

  4. Locomotive cab design development. volume 2 : operator's manual - Interim Report

    DOT National Transportation Integrated Search

    1976-10-01

    Locomotive Cab 913 designed as a result of Contract DOT-TSC- 913 has been built as a hard mock-up. This Operator's Manual is to familiarize the user with the mock-up. Normal and emergency procedures and cab facilities are described.

  5. Evaluation of stone/RAP interlayers under accelerated loading : construction report : interim report.

    DOT National Transportation Integrated Search

    2001-03-01

    Three test lanes were constructed at the Louisiana Pavement Research Facility to study the performance of Reclaimed Asphalt Pavement (RAP) as a stress relieving layer between the cement treated base and asphalt concrete layers in lieu of crushed ston...

  6. Cooper's Challenge

    ERIC Educational Resources Information Center

    Oder, Norman

    2007-01-01

    A funny thing happened while the District of Columbia Public Library (DCPL), already suffering from deteriorated facilities and systems, slogged through stasis (and three interim directors) after the 2003 departure of Director Molly Raphael. Mayor Anthony Williams presided over the city's economic turnaround--or, some charged, cozied up to…

  7. 75 FR 70126 - Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... of docket USCG-2010-0776 and are available online by going to http://www.regulations.gov , inserting... Guard received a total of one piece of correspondence in response to the temporary interim rule. No...

  8. DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaFreniere, L. M.; Environmental Science Division

    In October, 2007, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) presented the document Interim Measure Conceptual Design (Argonne 2007a) to the Kansas Department of Health and Environment, Bureau of Environmental Remediation (KDHE/BER), for a proposed non-emergency Interim Measure (IM) at the site of the former CCC/USDA grain storage facility in Centralia, Kansas (Figure 1.1). The IM was recommended to mitigate existing levels of carbon tetrachloride contamination identified in the vadose zone soils beneath the former facility and in the groundwater beneath and in the vicinity of the former facility, as well as to moderate or decreasemore » the potential future concentrations of carbon tetrachloride in the groundwater. The Interim Measure Conceptual Design (Argonne 2007a) was developed in accordance with the KDHE/BER Policy No.BERRS-029, Policy and Scope of Work: Interim Measures (KDHE 1996). The hydrogeologic, geochemical, and contaminant distribution characteristics of the Centralia site, as identified by the CCC/USDA, factored into the development of the nonemergency IM proposal. These characteristics were summarized in the Interim Measure Conceptual Design (Argonne 2007a) and were discussed in detail in previous Argonne reports (Argonne 2002a, 2003, 2004, 2005a,b,c, 2006a,b, 2007b). The identified remedial goals of the proposed IM were as follows: (1) To reduce the existing concentrations of carbon tetrachloride in groundwater in three 'hot spot' areas identified at the site (at SB01, SB05, and SB12-MW02; Figure 1.2) to levels acceptable to the KDHE. (2) To reduce carbon tetrachloride concentrations in the soils near the location of former soil boring SB12 and existing monitoring well MW02 (Figure 1.2) to levels below the KDHE Tier 2 Risk-Based Screening Level (RBSL) of 200 {micro}g/kg for this contaminant. To address these goals, the potential application of an in situ chemical reduction (ISCR) treatment technology, employing the use of the EHC{reg_sign} treatment materials marketed by Adventus Americas, Inc. (Freeport, Illinois), was recommended. The EHC materials are proprietary mixtures of food-grade organic carbon and zero-valent iron that are injected into the subsurface as a slurry (EHC) or in dissolved form (EHC-A) and subsequently released slowly into the formation. The materials are designed to create highly reducing geochemical conditions in the vadose and saturated zones that foster both thermodynamic and biological reductive dechlorination of carbon tetrachloride.« less

  9. Safety and effectiveness of 24-week treatment with iguratimod, a new oral disease-modifying antirheumatic drug, for patients with rheumatoid arthritis: interim analysis of a post-marketing surveillance study of 2679 patients in Japan.

    PubMed

    Mimori, Tsuneyo; Harigai, Masayoshi; Atsumi, Tatsuya; Fujii, Takao; Kuwana, Masataka; Matsuno, Hiroaki; Momohara, Shigeki; Takei, Syuji; Tamura, Naoto; Takasaki, Yoshinari; Ikeuchi, Satoshi; Kushimoto, Satoru; Koike, Takao

    2017-09-01

    To determine the real-world safety and effectiveness of iguratimod (IGU) for rheumatoid arthritis (RA), a 52-week, Japanese, post-marketing surveillance study was conducted. An interim analysis at week 24 was performed. This study included all RA patients who received IGU following its introduction to the market. All adverse events (AEs) and adverse drug reactions (ADRs) were collected. Effectiveness was evaluated by the change in Disease Activity Score 28-C-reactive protein (DAS28-CRP) from baseline to week 24. Safety was analyzed in 2679 patients. The overall incidences of AEs, ADRs, and serious ADRs were 38.41, 31.65, and 3.21%, respectively; the most commonly reported serious ADRs were pneumonia/bacterial pneumonia, interstitial lung disease, and Pneumocystis jiroveci pneumonia. Concomitant glucocorticoid use and comorbid conditions associated with respiratory disease were identified as risk factors for serious infections. Pulmonary alveolar hemorrhage and increased international normalized ratio of prothrombin time were observed with concomitant use of IGU and warfarin. The DAS28-CRP decreased from baseline to week 24. Although a safety concern was identified with concomitant use of IGU and warfarin, this real-world study showed no other new safety concerns and similar effectiveness to clinical trials. IGU is a new therapeutic option for RA patients.

  10. Interim Cryogenic Propulsion Stage (ICPS) for EM-1 Transport fro

    NASA Image and Video Library

    2017-04-11

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System rocket arrives at the Delta Operations Center at Cape Canaveral Air Force Station in Florida. The ICPS was moved from the United Launch Alliance (ULA) Horizontal Integration Facility near Space Launch Complex 37 at the Cape. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  11. Benchmarking of MCNP for calculating dose rates at an interim storage facility for nuclear waste.

    PubMed

    Heuel-Fabianek, Burkhard; Hille, Ralf

    2005-01-01

    During the operation of research facilities at Research Centre Jülich, Germany, nuclear waste is stored in drums and other vessels in an interim storage building on-site, which has a concrete shielding at the side walls. Owing to the lack of a well-defined source, measured gamma spectra were unfolded to determine the photon flux on the surface of the containers. The dose rate simulation, including the effects of skyshine, using the Monte Carlo transport code MCNP is compared with the measured dosimetric data at some locations in the vicinity of the interim storage building. The MCNP data for direct radiation confirm the data calculated using a point-kernel method. However, a comparison of the modelled dose rates for direct radiation and skyshine with the measured data demonstrate the need for a more precise definition of the source. Both the measured and the modelled dose rates verified the fact that the legal limits (<1 mSv a(-1)) are met in the area outside the perimeter fence of the storage building to which members of the public have access. Using container surface data (gamma spectra) to define the source may be a useful tool for practical calculations and additionally for benchmarking of computer codes if the discussed critical aspects with respect to the source can be addressed adequately.

  12. RH-TRU Waste Shipments from Battelle Columbus Laboratories to the Hanford Nuclear Facility for Interim Storage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Eide, J.; Baillieul, T. A.; Biedscheid, J.

    2003-02-26

    Battelle Columbus Laboratories (BCL), located in Columbus, Ohio, must complete decontamination and decommissioning (D&D) activities for nuclear research buildings and grounds by 2006, as directed by Congress. Most of the resulting waste (approximately 27 cubic meters [m3]) is remote-handled (RH) transuranic (TRU) waste destined for disposal at the Waste Isolation Pilot Plant (WIPP). The BCL, under a contract to the U.S. Department of Energy (DOE) Ohio Field Office, has initiated a plan to ship the TRU waste to the DOE Hanford Nuclear Facility (Hanford) for interim storage pending the authorization of WIPP for the permanent disposal of RH-TRU waste. Themore » first of the BCL RH-TRU waste shipments was successfully completed on December 18, 2002. This BCL shipment of one fully loaded 10-160B Cask was the first shipment of RH-TRU waste in several years. Its successful completion required a complex effort entailing coordination between different contractors and federal agencies to establish necessary supporting agreements. This paper discusses the agreements and funding mechanisms used in support of the BCL shipments of TRU waste to Hanford for interim storage. In addition, this paper presents a summary of the efforts completed to demonstrate the effectiveness of the 10-160B Cask system. Lessons learned during this process are discussed and may be applicable to other TRU waste site shipment plans.« less

  13. Safety, tolerability, efficacy and pharmacodynamics of the selective JAK1 inhibitor GSK2586184 in patients with systemic lupus erythematosus.

    PubMed

    Kahl, L; Patel, J; Layton, M; Binks, M; Hicks, K; Leon, G; Hachulla, E; Machado, D; Staumont-Sallé, D; Dickson, M; Condreay, L; Schifano, L; Zamuner, S; van Vollenhoven, R F

    2016-11-01

    We aimed to evaluate the pharmacodynamics, efficacy, safety and tolerability of the JAK1 inhibitor GSK2586184 in adults with systemic lupus erythematosus (SLE). In this adaptive, randomized, double-blind, placebo-controlled study, patients received oral GSK2586184 50-400 mg, or placebo twice daily for 12 weeks. Primary endpoints included interferon-mediated messenger RNA transcription over time, changes in Safety of Estrogen in Lupus National Assessment-SLE Disease Activity Index score, and number/severity of adverse events. A pre-specified interim analysis was performed when ≥ 5 patients per group completed 2 weeks of treatment. In total, 84-92% of patients were high baseline expressors of the interferon transcriptional biomarkers evaluated. At interim analysis, GSK2586184 showed no significant effect on mean interferon transcriptional biomarker expression (all panels). The study was declared futile and recruitment was halted at 50 patients. Shortly thereafter, significant safety data were identified, including elevated liver enzymes in six patients (one confirmed and one suspected case of Drug Reaction with Eosinophilia and Systemic Symptoms), leading to immediate dosing cessation. Safety of Estrogen in Lupus National Assessment-SLE Disease Activity Index scores were not analysed due to the small number of patients completing the study. The study futility and safety data described for GSK2586184 do not support further evaluation in patients with SLE. Study identifiers: GSK Study JAK115919; ClinicalTrials.gov identifier: NCT01777256.

  14. Safety and efficacy of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice: interim results of the STELLA-LONG TERM post-marketing surveillance study.

    PubMed

    Nakamura, Ichiro; Maegawa, Hiroshi; Tobe, Kazuyuki; Tabuchi, Hiromi; Uno, Satoshi

    2018-02-01

    Data regarding the efficacy and safety of sodium-glucose cotransporter 2 inhibitors in the real-world setting in Japan are limited. The STELLA-LONG TERM study is an ongoing 3-year post-marketing surveillance study of ipragliflozin in type 2 diabetes (T2D) patients. Here, we report the interim results (including 3-, 12-, and 24-month data). All Japanese patients with T2D who were first prescribed ipragliflozin between 17 July 2014 and 16 October 2015 at participating centers in Japan were registered in STELLA-LONG TERM. At 3, 12, and 24 months, the safety analysis set comprised 11,053, 5475, and 138 patients, respectively; the efficacy analysis set comprised 8757 patients. Ipragliflozin treatment resulted in statistically significant improvements versus baseline in hemoglobin A1c, fasting plasma glucose concentration, body weight, blood pressure, heart rate, and serum concentrations of low-density lipoprotein cholesterol and triglycerides. The adverse drug reaction incidence rate was 10.71%, the most common reactions being renal and urinary disorders (5.06%), infections and infestations (1.24%), and skin and subcutaneous tissue disorders (1.14%). Ipragliflozin was well tolerated and effective in Japanese patients with T2D; no new safety issues were identified.

  15. 40 CFR 265.254 - Design and operating requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....254 Section 265.254 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 265.254 Design and operating requirements. The owner or operator of each...

  16. Surveillance on The Safety and Efficacy of Ambrisentan (Volibris Tablet 2.5 mg) in Patients with Pulmonary Arterial Hypertension in Real Clinical Practice: Post-marketing Surveillance (Interim Analysis Report).

    PubMed

    Takahashi, Tomohiko; Hayata, Satoru; Kobayashi, Akihiro; Onaka, Yuna; Ebihara, Takeshi; Hara, Terufumi

    2018-03-01

    Pulmonary arterial hypertension (PAH) is an intractable and rare disease and the accumulation of clinical evidence under real-world setting is needed. A post-marketing surveillance for the endothelin receptor antagonist ambrisentan (Volibris tablet) has been conducted by all-case investigation since September 2010. This paper is an interim report on the safety and efficacy of ambrisentan in 702 patients with PAH. PAH patients aged 15 years or older were subjected to the analysis. The safety analysis by overall cases or stratification of patient backgrounds and the efficacy analysis were investigated. Regarding patient characteristics, the 702 patients subjected to safety analysis included 543 (77.4%) women and 546 (77.8%) patients at WHO functional class II/III. The mean observational time was 392.7 days. A total of 324 adverse drug reaction (ADR) occurred in 204 (29.1%) patients. Common ADRs (≥ 2%) included anemia (4.6%), peripheral edema (4.1%), headache (3.6%), edema and face edema (2.6% each), abnormal hepatic function (2.3%), and epistaxis (2.1%). There were 82 serious ADRs occurring in 44 (6.3%) patients (385 serious adverse events in 184 (26.2%) patients). Although 11 (1.6%) interstitial lung disease (ILD) cases were reported, all were observed in patients with disease that may contribute to ILD and therefore it is difficult to assess if ambrisentan was associated with these events. There was no difference in safety in relation to the presence/absence of connective tissue disease-related PAH (CTD-PAH) or combination therapy. Among 677 patients subjected to efficacy analysis, those in whom hemodynamic status was determined before and after treatment showed improvement in the mean pulmonary arterial pressure and pulmonary vascular resistance after treatment. The interim results showed safety consistent with the known profile of ambrisentan in terms of the types and frequencies of ADRs in patients with PAH in real clinical practice, in comparison with previous clinical trials in Japan and the rest of the world. Thus, these results provided another corroboration of the tolerability of ambrisentan and we continue to monitor proper use information via the post-marketing surveillance to ensure any new safety signals are identified in a timely manner (ClinTrial.gov: NCT01406327).

  17. Performance assessment for continuing and future operations at Solid Waste Storage Area 6

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-02-01

    This radiological performance assessment for the continued disposal operations at Solid Waste Storage Area 6 (SWSA 6) on the Oak Ridge Reservation (ORR) has been prepared to demonstrate compliance with the requirements of the US DOE. The analysis of SWSA 6 required the use of assumptions to supplement the available site data when the available data were incomplete for the purpose of analysis. Results indicate that SWSA 6 does not presently meet the performance objectives of DOE Order 5820.2A. Changes in operations and continued work on the performance assessment are expected to demonstrate compliance with the performance objectives for continuingmore » operations at the Interim Waste Management Facility (IWMF). All other disposal operations in SWSA 6 are to be discontinued as of January 1, 1994. The disposal units at which disposal operations are discontinued will be subject to CERCLA remediation, which will result in acceptable protection of the public health and safety.« less

  18. RCRA, superfund and EPCRA hotline training module. Introduction to: RCRA enforcement and compliance updated July 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-07-01

    The module describes enforcement procedures and cites the statutory authority and describes the two different types of enforcement (i.e., administrative and judicial). It explains when and how EPA can enforce the RCRA regulations in authorized states. It describes the enforcement mechanisms available to EPA. It states the differences between enforcement at interim status and permitted facilities. It describes enforcement at federal facilities and identifies relevant resource documents.

  19. RCRA/UST, superfund, and EPCRA hotline training module. Introduction to: RCRA enforcement and compliance, update as of July 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-11-01

    The module describds enforcement procedures and cites the statutory authority. It describes the two different types of enforcement (i.e., administrative and judicial) and explains when and how EPA can enforce the RCRA regulations in authorized states. It describes the enforcement mechanisms available to EPA. It states the differences between enforcement at interim status, permitted facilities, and Federal facilities. It also identifies relevant resources documents.

  20. Global Spent Fuel Logistics Systems Study (GSFLS). Volume 3A. GSFLS technical analysis (appendix). Interim report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kriger, A.

    1978-01-31

    This report is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. The technical and financial considerations underlying a global spent fuel logistics systems have been studied and are reported. The Pacific Basin is used as a model throughout this report; however the stated methodology and, in many cases, considerations and conclusions are applicable to other global regions. Spent fuel discharge profiles for Pacific Basin Countries were used to determine the technical systems requirements for alternative concepts. Functional analyses and flows were generated to define both system design requirements and logistics parameters. Amore » technology review was made to ascertain the state-of-the-art of relevant GSFLS technical systems. Modular GSFLS facility designs were developed using the information generated from the functional analysis and technology review. The modular facility designs were used as a basis for siting and cost estimates for various GSFLS alternatives. Various GSFLS concepts were analyzed from a financial and economic perspective in order to provide total concepts costs and ascertain financial and economic sensitivities to key GSFLS variations. Results of the study include quantification of GSFLS facility and hardware requirements; drawings of relevant GSFLS facility designs; system cost estimates; financial reports - including user service charges; and comparative analyses of various GSFLS alternatives.« less

  1. Environment, Safety, and Health: Status of DOE’s Reorganization of it’s Safety Oversight Function

    DTIC Science & Technology

    1990-01-01

    facilities. After deliberation, the Congress in late 1988 directed that the Defense Nuclear Facilities Safety Board be established to provide...nuclear safety matters will be conducted by either the Advisory Committee on Nuclear Facility Safety or the recently mandated Defense Nuclear Facilities Safety...the facilities under the statutory purview of the Defense Nuclear Facilities Safety Board once the board determines it is ready to assume independent

  2. Long-term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A.

    PubMed

    Nolan, B; Mahlangu, J; Perry, D; Young, G; Liesner, R; Konkle, B; Rangarajan, S; Brown, S; Hanabusa, H; Pasi, K J; Pabinger, I; Jackson, S; Cristiano, L M; Li, X; Pierce, G F; Allen, G

    2016-01-01

    The safety, efficacy and prolonged half-life of recombinant factor VIII Fc fusion protein (rFVIIIFc) in previously treated patients with severe haemophilia A was demonstrated in the phase 3 A-LONG and Kids A-LONG studies. Here, we report interim safety and efficacy data from the rFVIIIFc extension study, ASPIRE (ClinicalTrials.gov #NCT01454739). Eligible subjects could enrol in ASPIRE upon completing A-LONG or Kids A-LONG. There were four treatment groups: individualized prophylaxis; weekly prophylaxis; modified prophylaxis (for subjects in whom optimal treatment could not be achieved with individualized or weekly prophylaxis); and episodic treatment. The primary endpoint was development of inhibitors. A total of 150 A-LONG subjects and 61 Kids A-LONG subjects enrolled in ASPIRE. As of the interim data cut (6 January 2014), the median time on study was 80.9 (A-LONG) and 23.9 (Kids A-LONG) weeks. The majority of subjects (A-LONG, 92.0%; Kids A-LONG, 57.4%) had ≥100 cumulative rFVIIIFc exposure days. No inhibitors were observed. Adverse events were generally consistent with those expected in the general haemophilia A population. Median annualized bleeding rates (ABRs) were low with individualized [A-LONG: 0.66; Kids A-LONG: 0.00 (<6 years old), 1.54 (6 to <12 years old)], weekly (A-LONG: 2.03) and modified (A-LONG: 1.97) prophylaxis. There was no change in prophylactic infusion frequency or total weekly prophylactic dose in the majority of subjects from A-LONG and Kids A-LONG. Interim data from ASPIRE confirm the long-term safety of rFVIIIFc and the maintenance of a low ABR with extended-interval prophylactic dosing in patients with severe haemophilia A. © 2015 The Authors. Haemophilia Published by John Wiley & Sons Ltd.

  3. 40 CFR 445.10 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LANDFILLS POINT SOURCE CATEGORY RCRA Subtitle C Hazardous Waste Landfill § 445.10 Applicability. Except as provided in § 445.1, this subpart applies to discharges of wastewater from landfills subject to the... Disposal Facilities, Subpart N-(Landfills); and 40 CFR Part 265, Interim Status Standards for Owners and...

  4. Spent Nuclear Fuel (SNF) Project Execution Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LEROY, P.G.

    2000-11-03

    The Spent Nuclear Fuel (SNF) Project supports the Hanford Site Mission to cleanup the Site by providing safe, economic, environmentally sound management of Site spent nuclear fuel in a manner that reduces hazards by staging it to interim onsite storage and deactivates the 100 K Area facilities.

  5. Development of a conditioning system for the dual-purpose transport and storage cask for spent nuclear fuel from decommissioned Russian submarines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dyer, R.S.; Barnes, E.; Snipes, R.L.

    2007-07-01

    Russia, stores large quantities of spent nuclear fuel (SNF) from submarine and ice-breaker nuclear powered naval vessels. This high-level radioactive material presents a significant threat to the Arctic and marine environments. Much of the SNF from decommissioned Russian nuclear submarines is stored either onboard the submarines or in floating storage vessels in Northwest and Far East Russia. Some of the SNF is damaged, stored in an unstable condition, or of a type that cannot currently be reprocessed. In many cases, the existing Russian transport infrastructure and reprocessing facilities cannot meet the requirements for moving and reprocessing all of this fuelmore » from remote locations. Additional transport and storage options are required. Some of the existing storage facilities being used in Russia do not meet health and safety and physical security requirements. The U.S. has assisted Russia in the development of a new dual-purpose metal-concrete transport and storage cask (TUK-108/1) for their military SNF and assisted them in building several new facilities for off-loading submarine SNF and storing these TUK-108/1 casks. These efforts have reduced the technical, ecological, and security challenges for removal, handling, interim storage, and shipment of this submarine fuel. Currently, Russian licensing limits the storage period of the TUK-108/1 casks to no more than two years before the fuel must be shipped for reprocessing. In order to extend this licensed storage period, a system is required to condition the casks by removing residual water and creating an inert storage environment by backfilling the internal canisters with a noble gas such as argon. The U.S. has assisted Russia in the development of a mobile cask conditioning system for the TUK-108/1 cask. This new conditioning system allows the TUK 108/1 casks to be stored for up to five years after which the license may be considered for renewal for an additional five years or the fuel will be shipped to 'Mayak' for reprocessing. The U.S. Environmental Protection Agency (EPA), in cooperation with the U.S. DOD Office of Cooperative Threat Reduction (CTR), and the DOE's ORNL, along with the Norwegian Defense Research Establishment, worked closely with the Ministry of Defense and the Ministry of Atomic Energy of the Russian Federation (RF) to develop an improved integrated management system for interim storage of military SNF in Russia. The initial Project activities included: (1) development of a prototype dual-purpose, metal-concrete 40-ton cask for both the transport and interim storage of RF SNF, and (2) development of the first transshipment/interim storage facility for these casks in Murmansk. The U.S. has continued support to the project by assisting the RF with the development of the first mobile system that provides internal conditioning for the TUK-108/1 casks to allow them to be stored for longer than the current licensing period of two years. Development of the prototype TUK-108/1 cask was completed in December 2000 under the Arctic Military Environmental Cooperation (AMEC) Program. This was the first metal-concrete cask developed, licensed, and produced in the RF for both the transportation and storage of SNF from decommissioned submarines. These casks are currently being serially produced in NW Russia and 108 casks have been produced to date. Russia is using these casks for the transport and interim storage of military SNF from decommissioned nuclear submarines at naval installations in the Arctic and Far East in conformance with the Strategic Arms Reduction Treaty (START II). The design, construction, and commissioning of the first transshipment/interim storage facility in the RF was completed and ready for full operation in September 2003. Because of the RF government reorganization and changing regulations for spent fuel storage facilities, the storage facility at Murmansk was not fully licensed for operation until December 2005. The RF has reported that the facility is now fully operational. The TUK-108/1 SNF transport and storage casks were designed to have a 50-year storage life. Current RF practice is not to condition the submarine SNF or cask during the cask loading. Current RF regulations allow up to 4 mm of residual water (up to 3.2 liters) to remain in the casks. It has been determined that allowing this amount of residual water to remain untreated for a period longer than two years can produce hydrogen gas through hydrolysis which will increase the risk of explosion and could cause some corrosion of internal components. A solution to this problem was to develop and utilize a cask conditioning system to remove the residual water and create an inert storage environment in the cask by back-filling the internal cask cavity with an inert gas, such as helium or argon. This system is compatible with the existing TUK-108/1 design and is mobile for use at multiple submarine dismantlement sites. The RF has required that this cask conditioning system be tested and commissioned at the 'Zvezda' Shipyard in the Far East near Vladivostok, one of the major RF submarine fuel off loading and storage facilities. Currently, the fuel cannot be transferred to 'Mayak' for reprocessing until the completion of the 20 km railroad connector between 'Zvezda' and the main rail line to 'Mayak'. The cask conditioning system will allow extension of the currently-stored casks for an additional three years, at which time the rail connector line should be completed. The current license to store these casks at 'Zvezda' was scheduled to expire on 31 Dec 2006. Without the cask-conditioning system, the license could not be extended, no more fuel could be off-loaded from the decommissioned submarines, and the START objectives could not be met at 'Zvezda'. Completion of this cask conditioning system has removed a significant bottleneck for the completion of the Russian submarine decommissioning program under the START II Agreement. (authors)« less

  6. Safety implications of the use of the flashing yellow arrow for permissive left turns.

    DOT National Transportation Integrated Search

    2011-01-01

    The use of the flashing yellow arrow (FYA) for permissive left turns is relatively new to California, with at least five : installations approved under a 2006 Federal Highway Administration (FHWA) Interim Approval memorandum. : Inclusion of formal gu...

  7. Erlotinib 150 mg daily plus chemotherapy in advanced pancreatic cancer: an interim safety analysis of a multicenter, randomized, cross-over phase III trial of the 'Arbeitsgemeinschaft Internistische Onkologie'.

    PubMed

    Boeck, Stefan; Vehling-Kaiser, Ursula; Waldschmidt, Dirk; Kettner, Erika; Märten, Angela; Winkelmann, Cornelia; Klein, Stefan; Kojouharoff, Georgi; Gauler, Thomas; Fischer von Weikersthal, Ludwig; Clemens, Michael R; Geissler, Michael; Greten, Tim F; Hegewisch-Becker, Susanna; Neugebauer, Sascha; Heinemann, Volker

    2010-01-01

    To date, only limited toxicity data are available for the combination of erlotinib with either capecitabine or gemcitabine as front-line therapy for advanced pancreatic cancer. Within a randomized phase III trial, 281 treatment-naive patients were randomly assigned between capecitabine (2000 mg/m/day, for 14 days, once every 3 weeks) plus erlotinib (150 mg/day, arm A) and gemcitabine (1000 mg/m as a 30-min infusion) plus erlotinib (150 mg/day, arm B). In case of treatment failure, patients were crossed over to a second-line treatment with the comparator cytostatic drug without erlotinib. The primary study endpoint was the time to treatment failure of second-line therapy (TTF2). This interim analysis of toxicity contains safety data from the first 127 randomized patients. During first-line therapy, patients received a median number of three treatment cycles (range 0-13) in both the arms. Regarding chemotherapy, a treatment delay was observed in 12% of the cycles in arm A and in 22% of the cycles in arm B. Dose reductions of the cytostatic drug were performed in 18 and 27% of treatment cycles, respectively. Erlotinib dose reductions were performed in 6 and 11% of all cycles. Grade 3/4 hematological toxicity was <10% in both the arms; major grade 3/4 toxicities in arms A and B were diarrhea (9 vs. 7%), skin rash (4 vs. 12%), and hand-foot syndrome (7 vs. 0%). No treatment-related death was observed. In conclusion, this interim safety analysis suggests that treatment with erlotinib 150 mg/day is feasible in combination with capecitabine or gemcitabine.

  8. Issues with monitoring the safety of psychoactive products under a legal regulated market for new psychoactive substances ('legal highs') in New Zealand.

    PubMed

    Rychert, Marta; Wilkins, Chris; Witten, Karen

    2017-09-01

    New Zealand's Psychoactive Substances Act (2013) established the world's first regulated market for 'low risk' psychoactive products ('legal highs'). Under an interim PSA regime, 47 existing products were permitted to be continued to be sold. To explore issues with the implementation of regulatory systems to monitor the safety of products on the legal market under the interim Psychoactive Substances Act regime. Semi-structured interviews with 30 key stakeholders, including industry, government agency, health and drug service professionals were conducted, transcribed and analysed thematically. In retrospect stakeholders questioned the decision to approve strong synthetic cannabinoid smoking products, noting their health risks because of product formulation, inconsistent manufacturing practices and smoking as the means of administration. Industry actors claimed the decision to approve synthetic cannabinoid smokeable products prevented potentially safer products from gaining market share. The system for withdrawing approved products which were subsequently found to be harmful was criticised for the poor quality of data available, limited engagement with health professionals and the slowness of product withdrawal. Many of the problems with the regime were attributed to the urgency under which the legal market under the interim Psychoactive Substances Act was established and implemented. The selection of 'safer' products, implementation of the product monitoring system, and engagement with health professionals may have benefited from more time and resources. An incremental approach to establishing the new market may have made the regulatory management of the new regime more workable. [Rychert M, Wilkins C, Witten K. Issues with monitoring the safety of psychoactive products under a legal regulated market for new psychoactive substances ('legal highs') in New Zealand. Drug Alcohol Rev 2017;00:000-000]. © 2017 Australasian Professional Society on Alcohol and other Drugs.

  9. 40 CFR 265.112 - Closure plan; amendment of plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND.... By May 19, 1981, or by six months after the effective date of the rule that first subjects a facility... description of other activities necessary during the partial and final closure periods to ensure that all...

  10. Hazardous Waste Management System - Identification and Listing of Hazardous Waste - Toxicity Characteristic - Hydrocarbon Recovery Operations - Federal Register Notice, October 5, 1990

    EPA Pesticide Factsheets

    The Agency is promulgating an interim final rule to extend the compliance date of the Toxicity Characteristic rule for petroleum refining facilities, marketing terminals and bulk plants engaged in the recovery and remediation operation for 120 days.

  11. 76 FR 30184 - Outer Continental Shelf (OCS) Renewable Energy Program Interim Policy Leasing for Marine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... DEPARTMENT OF THE INTERIOR Bureau of Ocean Energy Management, Regulation and Enforcement [Docket..., Regulation and Enforcement (BOEMRE), Interior. ACTION: Notice of Intent (NOI) to Prepare an Environmental... technology testing facility located on the OCS, in accordance with the Department of the Interior and the...

  12. Development of performance specifications for collision avoidance systems for lane change crashes. Task 6, interim report : testbed systems design and associated facilities

    DOT National Transportation Integrated Search

    2001-11-01

    This report documents the design of an on-road testbed vehicle. The purposes of this testbed are twofold: (1) Establish a foundation for estimating lane change collision avoidance effectiveness, and (2) provide information pertinent to setting perfor...

  13. Radon Reduction Techniques in Schools: Interim Technical Guidance.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    This technical document is intended to assist school facilities maintenance personnel in the selection, design, and operation of radon reduction systems in schools. The guidance contained in this document is based largely on research conducted in 1987 and 1988 in schools located in Maryland and Virginia. Researchers from the United States…

  14. 77 FR 55781 - Port Access Route Study: The Atlantic Coast from Maine to Florida

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... the interim report or submission of additional information for consideration by the workgroup. DATES...) Mail: Docket Management Facility (M-30), U.S. Department of Transportation, West Building Ground Floor... Participation and Request for Comments'' portion of the SUPPLEMENTARY INFORMATION section below for instructions...

  15. Superfund Record of Decision (EPA Region 4): Milan Army Ammunition Plant, TN. (First remedial action), September 1992. Interim report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-09-30

    The 22,436-acre Milan Army Ammunition Plant (MAAP) is located in western Tennessee, 5 miles east of Milan, Tennessee. The facility was constructed in 1941 to produce and store fuses, boosters, and small- and large-caliber ammunition. The ROD addresses an interim remedy for the contaminated ground water beneath and immediately downgradient from the former ponds as OU1. The primary contaminants of concern affecting the ground water are VOCs, including carbon disulfide; other organics, including HMX, RDX, 2,4,6-TNT, 2,4-DNT, 2,6-DNT, 1,3-DNB, 1,3,5-trinitrobenzene, and nitrobenzene; and inorganics, including nitrate.

  16. Interim Cryogenic Propulsion Stage (ICPS) Transport from DOC to

    NASA Image and Video Library

    2017-07-26

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket, packed inside a canister, exits the United Launch Alliance (ULA) Delta Operations Center near Space Launch Complex 37 at Cape Canaveral Air Force Station for its move to the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  17. Interim Cryogenic Propulsion Stage (ICPS) for EM-1 Transport fro

    NASA Image and Video Library

    2017-04-11

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System rocket is moved inside the Delta Operations Center at Cape Canaveral Air Force Station in Florida. The ICPS was moved from the United Launch Alliance (ULA) Horizontal Integration Facility near Space Launch Complex 37 at the Cape. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  18. Interim Cryogenic Propulsion Stage (ICPS) Prep for Transport fro

    NASA Image and Video Library

    2017-07-25

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket is packed inside a canister and ready to be moved from the United Launch Alliance (ULA) Delta Operations Center near Space Launch Complex 37 at Cape Canaveral Air Force Station to the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  19. Interim Cryogenic Propulsion Stage (ICPS) for EM-1 Transport fro

    NASA Image and Video Library

    2017-04-11

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket has been moved on its transport stand by truck out of the United Launch Alliance (ULA) Horizontal Integration Facility near Space Launch Complex 37 at Cape Canaveral Air Force Station in Florida. The ICPS will be transported to the Delta Operations Center. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  20. Interim Cryogenic Propulsion Stage (ICPS) for EM-1 Transport fro

    NASA Image and Video Library

    2017-04-11

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket is moved on its transport stand by truck out of the United Launch Alliance (ULA) Horizontal Integration Facility near Space Launch Complex 37 at Cape Canaveral Air Force Station in Florida. The ICPS will be transported to the Delta Operations Center. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  1. Interim Cryogenic Propulsion Stage (ICPS) for EM-1 Transport fro

    NASA Image and Video Library

    2017-04-11

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket has been moved on its transport stand by truck out of the United Launch Alliance (ULA) Horizontal Integration Facility near Space Launch Complex 37 at Cape Canaveral Air Force Station in Florida, on its way to the Delta Operations Center. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  2. Interim Cryogenic Propulsion Stage (ICPS) Transport from DOC to

    NASA Image and Video Library

    2017-07-26

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket, packed inside a canister, is transported from the United Launch Alliance (ULA) Delta Operations Center near Space Launch Complex 37 at Cape Canaveral Air Force Station along the route to the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  3. Interim Cryogenic Propulsion Stage (ICPS) for EM-1 Transport fro

    NASA Image and Video Library

    2017-04-11

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket has been moved on its transport stand by truck out of the United Launch Alliance (ULA) Horizontal Integration Facility near Space Launch Complex 37 at Cape Canaveral Air Force Station in Florida, and is on its way to the Delta Operations Center. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission 1.

  4. Installation Development Environmental Assessment at Joint Base Andrews-Naval Air Facility Washington Prince George’s County, Maryland

    DTIC Science & Technology

    2013-04-01

    and seven additional aircraft by fiscal year (FY) 16. As an interim solution, temporary trailers totaling 4,000 square feet (SF) are being used on a...hangar floor to accommodate office space and aircrew flight equipment workshop needs. However, the use of trailers comes at a direct cost to the...facility would have 18 classrooms, a gross motor room, a lobby with reception area, a conference room, administrative offices, a staff lounge, a full-service

  5. IRIS thermal balance test within ESTEC LSS

    NASA Technical Reports Server (NTRS)

    Messidoro, Piero; Ballesio, Marino; Vessaz, J. P.

    1988-01-01

    The Italian Research Interim Stage (IRIS) thermal balance test was successfully performed in the ESTEC Large Space Simulator (LSS) to qualify the thermal design and to validate the thermal mathematical model. Characteristics of the test were the complexity of the set-up required to simulate the Shuttle cargo bay and allowing IRIS mechanism actioning and operation for the first time in the new LSS facility. Details of the test are presented, and test results for IRIS and the LSS facility are described.

  6. U.S. Department of Transportation's intelligent transportation infrastructure deployment database : interim report

    DOT National Transportation Integrated Search

    2013-04-01

    Connected Vehicle to Vehicle (V2V) safety applications heavily rely on the BSM, which is one of the messages defined in the Society of Automotive standard J2735, Dedicated Short Range Communications (DSRC) Message Set Dictionary, November 2009. The B...

  7. Phase I interim report : automotive collision avoidance system field operational test

    DOT National Transportation Integrated Search

    2002-05-30

    In June of 1999, the National Highway Traffic Safety Administration entered into a cooperative research agreement with General Motors to advance the state-of-the-art of rear-end collision warning technology and conduct a field operational test of a f...

  8. An evaluation of the short-term effects of the Virginia driver improvement program : interim report.

    DOT National Transportation Integrated Search

    1981-01-01

    This study attempted to determine the impact of the driver improvement program on Virginia's traffic and safety environment in terms of accidents and traffic convictions averted as a result of appropriate treatment, and to establish an ongoing system...

  9. 33 CFR 157.500 - Purpose and applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Interim Measures for Certain Tank Vessels Without Double Hulls Carrying Animal Fat or... safety and operational requirements to reduce environmental damage resulting from the discharge of animal...

  10. 33 CFR 157.500 - Purpose and applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Interim Measures for Certain Tank Vessels Without Double Hulls Carrying Animal Fat or... safety and operational requirements to reduce environmental damage resulting from the discharge of animal...

  11. 33 CFR 157.500 - Purpose and applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Interim Measures for Certain Tank Vessels Without Double Hulls Carrying Animal Fat or... safety and operational requirements to reduce environmental damage resulting from the discharge of animal...

  12. Rolling out of kangaroo mother care in secondary level facilities in Bihar-Some experiences.

    PubMed

    Neogi, Sutapa B; Chauhan, Monika; Sharma, Jyoti; Negandhi, Preeti; Sethy, Ghanshyam

    2016-01-01

    Preterm birth is one of the leading causes of under-five child deaths worldwide and in India. Kangaroo mother care (KMC) is a powerful and easy-to-use method to promote health and well-being and reduce morbidity and mortality in preterm/low birth weight (LBW) babies. As the part of the roll-out of India Newborn Action Plan interventions, we implemented KMC in select facilities with an objective to assess the responsiveness of public health system to roll out KMC. KMC intervention was implemented in two select high priority districts, Gaya and Purnea in Bihar over the duration of 8 months from August 2015 to March 2016. The implementation of intervention was phased out into; situation analysis, implementation of intervention, and interim assessment. KMC model, as envisaged keeping in mind the building blocks of health system, was established in 6 identified health-care facilities. A pretested simple checklist was used to assess the awareness, knowledge, skills, and practice of KMC during baseline situational analysis and interim assessment phases for comparison. The intervention clearly seemed to improve the awareness among auxiliary nurse midwives/nurses about KMC. Improvements were also observed in the availability of infrastructure required for KMC and support logistics like facility for manual expression of breast milk, cups/suitable devices such as paladi cups for feeding small babies and digital weighing scale. Although the recording of information regarding LBW babies and KMC practice improved, still there is scope for much improvement. There is a commitment at the national level to promote KMC in every facility. The present experience shows the possibility of rolling out KMC in secondary level facilities with support from government functionaries.

  13. Safety and Efficacy of Teneligliptin in Patients with Type 2 Diabetes Mellitus and Impaired Renal Function: Interim Report from Post-marketing Surveillance.

    PubMed

    Haneda, Masakazu; Kadowaki, Takashi; Ito, Hiroshi; Sasaki, Kazuyo; Hiraide, Sonoe; Ishii, Manabu; Matsukawa, Miyuki; Ueno, Makoto

    2018-06-01

    Teneligliptin is a novel oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM). Safety and efficacy of teneligliptin have been demonstrated in clinical studies; however, data supporting its use in patients with moderate or severe renal impairment are limited. This interim analysis of a post-marketing surveillance of teneligliptin, exploRing the long-term efficacy and safety included cardiovascUlar events in patients with type 2 diaBetes treated bY teneligliptin in the real-world (RUBY), aims to verify the long-term safety and efficacy of teneligliptin in Japanese patients with T2DM and impaired renal function. For this analysis, we used the data from case report forms of the RUBY surveillance between May 2013 and June 2017. The patients were classified into G1-G5 stages of chronic kidney disease according to estimated glomerular filtration rate (eGFR) at initiation of teneligliptin treatment. Safety and efficacy were evaluated in these subgroups. Patients on dialysis were also assessed. Safety was assessed from adverse drug reactions (ADRs). Glycemic control was evaluated up to 2 years after teneligliptin initiation. A total of 11,677 patients were enrolled in the surveillance and 11,425 patient case-report forms were collected for the interim analysis. The incidence of ADRs in each subgroup was 2.98-6.98% of patients, with no differences in the ADR profile (including hypoglycemia and renal function ADRs) between subgroups. At 1 and 2 years after starting teneligliptin, the least-squares mean change in HbA1c adjusted to the baseline was - 0.68 to - 0.85% and - 0.71 to - 0.85% across the eGFR groups, respectively. Treatment with teneligliptin in patients on dialysis reduced or tended to reduce glycated albumin levels [- 2.29%, (p < 0.001) after 1 year; - 1.64%, (p = 0.064) after 2 years]. During long-term treatment, teneligliptin was generally well tolerated in patients with any stage of renal impairment from normal to end-stage renal disease, including those on dialysis, and improved glycemic control. Japic CTI-153047. Mitsubishi Tanabe Pharma Corporation and Daiichi Sankyo Co, Ltd.

  14. Grout Isolation and Stabilization of Structures and Materials within Nuclear Facilities at the U.S. Department of Energy, Hanford Site, Summary - 12309

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Phillips, S.J.; Phillips, M.; Etheridge, D.

    2012-07-01

    Per regulatory agreement and facility closure design, U.S. Department of Energy Hanford Site nuclear fuel cycle structures and materials require in situ isolation in perpetuity and/or interim physicochemical stabilization as a part of final disposal or interim waste removal, respectively. To this end, grout materials are being used to encase facilities structures or are being incorporated within structures containing hazardous and radioactive contaminants. Facilities where grout materials have been recently used for isolation and stabilization include: (1) spent fuel separations, (2) uranium trioxide calcining, (3) reactor fuel storage basin, (4) reactor fuel cooling basin transport rail tanker cars and casks,more » (5) cold vacuum drying and reactor fuel load-out, and (6) plutonium fuel metal finishing. Grout components primarily include: (1) portland cement, (2) fly ash, (3) aggregate, and (4) chemical admixtures. Mix designs for these typically include aggregate and non aggregate slurries and bulk powders. Placement equipment includes: (1) concrete piston line pump or boom pump truck for grout slurry, (2) progressive cavity and shearing vortex pump systems, and (3) extendable boom fork lift for bulk powder dry grout mix. Grout slurries placed within the interior of facilities were typically conveyed utilizing large diameter slick line and the equivalent diameter flexible high pressure concrete conveyance hose. Other facilities requirements dictated use of much smaller diameter flexible grout conveyance hose. Placement required direct operator location within facilities structures in most cases, whereas due to radiological dose concerns, placement has also been completed remotely with significant standoff distances. Grout performance during placement and subsequent to placement often required unique design. For example, grout placed in fuel basin structures to serve as interim stabilization materials required sufficient bearing i.e., unconfined compressive strength, to sustain heavy equipment yet, low breakout force to permit efficient removal by track hoe bucket or equivalent construction equipment. Further, flow of slurries through small orifice geometries of moderate head pressures was another typical design requirement. Phase separation of less than 1 percent was a typical design requirement for slurries. On the order of 30,000 cubic meters of cementitious grout have recently been placed in the above noted U.S. Department of Energy Hanford Site facilities or structures. Each has presented a unique challenge in mix design, equipment, grout injection or placement, and ultimate facility or structure performance. Unconfined compressive and shear strength, flow, density, mass attenuation coefficient, phase separation, air content, wash-out, parameters and others, unique to each facility or structure, dictate the grout mix design for each. Each mix design was tested under laboratory and scaled field conditions as a precursor to field deployment. Further, after injection or placement of each grout formulation, the material was field inspected either by standard laboratory testing protocols, direct physical evaluation, or both. (authors)« less

  15. Predicting clinical trial results based on announcements of interim analyses

    PubMed Central

    2014-01-01

    Background Announcements of interim analyses of a clinical trial convey information about the results beyond the trial’s Data Safety Monitoring Board (DSMB). The amount of information conveyed may be minimal, but the fact that none of the trial’s stopping boundaries has been crossed implies that the experimental therapy is neither extremely effective nor hopeless. Predicting success of the ongoing trial is of interest to the trial’s sponsor, the medical community, pharmaceutical companies, and investors. We determine the probability of trial success by quantifying only the publicly available information from interim analyses of an ongoing trial. We illustrate our method in the context of the National Surgical Adjuvant Breast and Bowel (NSABP) trial, C-08. Methods We simulated trials based on the specifics of the NSABP C-08 protocol that were publicly available. We quantified the uncertainty around the treatment effect using prior weights for the various possibilities in light of other colon cancer studies and other studies of the investigational agent, bevacizumab. We considered alternative prior distributions. Results Subsequent to the trial’s third interim analysis, our predictive probabilities were: that the trial would eventually be successful, 48.0%; would stop for futility, 7.4%; and would continue to completion without statistical significance, 44.5%. The actual trial continued to completion without statistical significance. Conclusions Announcements of interim analyses provide information outside the DSMB’s sphere of confidentiality. This information is potentially helpful to clinical trial prognosticators. ‘Information leakage’ from standard interim analyses such as in NSABP C-08 is conventionally viewed as acceptable even though it may be quite revealing. Whether leakage from more aggressive types of adaptations is acceptable should be assessed at the design stage. PMID:24607270

  16. Summary of Federal Aviation Administration Responses to National Transportation Safety Board Safety Recommendations.

    DTIC Science & Technology

    1981-01-01

    NASA was already being incorporated by several equipment manufacturers in their own development plans. A-78-29. In the interim, amend 14 CFR to...not necessary. Research and development previously accomplished by the U.S. Army and by NASA was already being incorporated by several equipment...by industry., On July 12, our Bureau of Technology hosted a U.S. Army/FAA/ NASA meeting to brief FAA and NASA representatives, at the technical level

  17. Health: Overview. Interim Guide.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    The Manitoba Health Education Curriculum focuses on promoting the development of positive lifestyle practices in students from kindergarten through grade nine. The core units of the program are: (1) social-emotional well-being; (2) physical well-being; (3) nutrition; (4) dental health; (5) safety; and (6) environmental health. This overview offers…

  18. Development Of Performance Specifications For Collision Avoidance Systems For Lane Change, Merging, And Backing, Task 3 - Interim Report: Test Of Existing Hardware

    DOT National Transportation Integrated Search

    1995-05-01

    KEYWORDS : ADVANCED VEHICLE CONTROL & SAFETY SYSTEMS OR AVCSS, COLLISION WARNING/AVOIDANCE SYSTEMS, CRASH REDUCTION, INTELLIGENT VEHICLE INITIATIVE OR IVI : RESULTS FROM THE TESTING OF ELEVEN COLLISION AVOIDANCE SYSTEMS (CAS) FOR LANE CHANGE, ...

  19. A NEW, SMALL DRYING FACILITY FOR WET RADIOACTIVE WASTE AND LIQUIDS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oldiges, Olaf; Blenski, Hans-Juergen

    2003-02-27

    Due to the reason, that in Germany every Waste, that is foreseen to be stored in a final disposal facility or in a long time interim storage facility, it is necessary to treat a lot of waste using different drying technologies. In Germany two different drying facilities are in operation. The GNS Company prefers a vacuum-drying-technology and has built and designed PETRA-Drying-Facilities. In a lot of smaller locations, it is not possible to install such a facility because inside the working areas of that location, the available space to install the PETRA-Drying-Facility is too small. For that reason, GNS decidedmore » to design a new, small Drying-Facility using industrial standard components, applying the vacuum-drying-technology. The new, small Drying-Facility for wet radioactive waste and liquids is presented in this paper. The results of some tests with a prototype facility are shown in chapter 4. The main components of that new facility are described in chapter 3.« less

  20. Radiological characterization of skyshine from a retired, low-level, radioactive liquid effluent disposal facility at Hanford

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brown, R.C.; Perkins, C.J.

    1991-02-01

    The 1301-N Liquid Waste Disposal Facility, located on the Hanford Site received N Reactor low-level radioactive liquid process effluent from 1962 to 1985. Radiation emanating from the top of the trench sections was not significant because of the sediments were normally under several meters of water, which provided the necessary shielding. Following retirement of the facility, the liquid in the trench sections percolated into the ground leaving the residual radioactively contaminated sediments unshielded along the bottom and sides of the trench sections. The radioactive constituents of the contaminated sediments include the gamma-emitting isotopes Co-60 and Cs-137. Because of the lackmore » of water covering, some of the gamma photons that were emitted upward were scattered downward due to Compton interaction with atmospheric constituents. This phenomenon is known as skyshine.'' A radiological characterization was required to provide guidance for determining the effectiveness of interim stabilization alternatives that would not adversely affect future Resource Conservation and Recovery Act site closure activities, (e.g., filling in trench sections with spoils from excavation activities). A noninvasive radiological characterization of this disposal facility and the affected area of the Columbia River shoreline was conducted. This characterization confirmed that skyshine is the cause of the elevated shoreline exposure rates and provided a model that could be used to rate the effectiveness of alternative interim stabilization measures. 4 refs., 5 figs.« less

  1. Evaluation of the HOPE Act: New State Services for Street Youth. Interim Report.

    ERIC Educational Resources Information Center

    McLain, Barbara

    This report reviews the effectiveness of Washington's HOPE Centers and Responsible Living Skills Programs (RLSPs) and reports findings and recommendations. In 1999, state legislators enacted the HOPE Act, which created these two services. HOPE Centers are temporary residential facilities where street youth can stay for 30 days while being…

  2. 78 FR 79674 - Endangered and Threatened Species; Take of Anadromous Fish

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... and eggs from the Feather River Fish Hatchery (FRFH) and their release into the San Joaquin River or... eggs produced or reared at either the interim facility or the permanent SCARF (from broodstock...,400 CV spring-run Chinook salmon juveniles or 80,000 CV spring-run Chinook salmon eggs originating...

  3. 45 CFR 86.71 - Interim procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Equipment, 86.41(c) Expenditures, 86.41(c) Facilities, 86.41(c) Travel, 86.41(c) Scholarships, [64, 65]; 86...-time employees, [89] G Grievance Procedure, see “Designation of responsible employee”, 86.8(a) (b) H... Undergraduate Professional Schools, [30]; 86.15(d) Purpose of Regulation, [13]; 86.1 R Real Property, 86.2(g...

  4. Development of performance specifications for collision avoidance systems for lane change, merging, and backing. Task 6, Interim report : testbed systems design and associated facilities

    DOT National Transportation Integrated Search

    1997-05-01

    This report represents the documentation of the design of the testbed. The purposes of the testbed are twofold 1) Establish a foundation for estimating collision avoidance effectiveness and 2) Provide information pertinent to setting performance spec...

  5. 76 FR 77479 - Foreign-Trade Zone 7-Mayaguez, PR; Application for Temporary/Interim Manufacturing Authority...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... (Pharmaceutical and Nutritional Intravenous Bags and Administration Sets); Aibonito and Jayuya, PR An application... Baxter facilities (200 million unit capacity) are used for the manufacture of pharmaceutical and... authority to produce filled pharmaceutical and nutritional I.V. bags (HTSUS 3004.20, 3004.40, 3004.50, 3004...

  6. 40 CFR 265.442 - Design and installation of new drip pads.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Design and installation of new drip pads. 265.442 Section 265.442 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Drip Pads §...

  7. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  8. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  9. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  10. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  11. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste, the... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Making the hazardous waste... 262.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...

  12. Cementitious waste option scoping study report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, A.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) on the Idaho National Engineering and Environmental Laboratory (INEEL) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This study investigates the nonseparations Cementitious Waste Option (CWO) as a means to achieve this goal. Under this option all liquid sodium-bearing waste (SBW) and existing HLW calcine would be recalcined with sucrose, grouted, canisterized, and interim stored asmore » a mixed-HLW for eventual preparation and shipment off-Site for disposal. The CWO waste would be transported to a Greater Confinement Disposal Facility (GCDF) located in the southwestern desert of the US on the Nevada Test Site (NTS). All transport preparation, shipment, and disposal facility activities are beyond the scope of this study. CWO waste processing, packaging, and interim storage would occur over a 5-year period between 2013 and 2017. Waste transport and disposal would occur during the same time period.« less

  13. 78 FR 17835 - Approval and Promulgation of Federal Implementation Plan for Oil and Natural Gas Well Production...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ...The EPA is taking final action to promulgate a Reservation- specific Federal Implementation Plan in order to regulate emissions from oil and natural gas production facilities located on the Fort Berthold Indian Reservation in North Dakota. The Federal Implementation Plan includes basic air quality regulations for the protection of communities in and adjacent to the Fort Berthold Indian Reservation. The Federal Implementation Plan requires owners and operators of oil and natural gas production facilities to reduce emissions of volatile organic compounds emanating from well completions, recompletions, and production and storage operations. This Federal Implementation Plan will be implemented by the EPA, or a delegated tribal authority, until replaced by a Tribal Implementation Plan. The EPA proposed a Reservation-specific Federal Implementation Plan concurrently with an interim final rule on August 15, 2012. This final Federal Implementation Plan replaces the interim final rule in all intents and purposes on the effective date of the final rule. The EPA is taking this action pursuant to the Clean Air Act (CAA).

  14. Tri-level study of the causes of traffic accidents : interim report 1. Vol. 1, research findings

    DOT National Transportation Integrated Search

    1973-08-31

    This is the final report of the first year of activity under a proposed three-year program entitled "Tri-Level Study of the Causes of Traffic Accidents." This study has been performed by the Indiana University institute for Research in Public Safety ...

  15. Tri-level study of the causes of traffic accidents : interim report 1. Vol. 2 : appendices

    DOT National Transportation Integrated Search

    1973-08-31

    This is the final report of the first year of activity under a proposed three-year program entitled "Tri-Level Study of the Causes of Traffic Accidents." This study has been performed by the Indiana University Institute for Research in Public Safety ...

  16. 16 CFR 1209.6 - Test procedures for critical radiant flux.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... radiant flux of exposed attic floor insulation using a radiant heat energy source. (a) Apparatus and... ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.6 Test procedures... radiant heat energy panel or equivalent panel inclined at 30° above and directed at a horizontally-mounted...

  17. 16 CFR 1209.6 - Test procedures for critical radiant flux.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... radiant flux of exposed attic floor insulation using a radiant heat energy source. (a) Apparatus and... ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.6 Test procedures... radiant heat energy panel or equivalent panel inclined at 30° above and directed at a horizontally-mounted...

  18. 16 CFR 1209.6 - Test procedures for critical radiant flux.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... radiant flux of exposed attic floor insulation using a radiant heat energy source. (a) Apparatus and... ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.6 Test procedures... radiant heat energy panel or equivalent panel inclined at 30° above and directed at a horizontally-mounted...

  19. 16 CFR 1209.6 - Test procedures for critical radiant flux.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... radiant flux of exposed attic floor insulation using a radiant heat energy source. (a) Apparatus and... ACT REGULATIONS INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION The Standard § 1209.6 Test procedures... radiant heat energy panel or equivalent panel inclined at 30° above and directed at a horizontally-mounted...

  20. 77 FR 62596 - Interim Guidance on State Freight Plans and State Freight Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...), Maritime Administration (MARAD), Pipeline and Hazardous Materials Safety Administration (PHSMA), Research... Research Program (23 U.S.C. 505). They may also use carryover balances from National Highway System funds... system's users and to the general public (for example, reductions in crashes, fatalities, and injuries...

  1. 76 FR 33184 - Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... multiple OPs from 2001-2005. Furthermore, the USDA Food Safety and Inspection Service (FSIS) monitors meat... Food, Drug, and Cosmetic Act (FFDCA). DATES: Comments, identified by docket identification (ID) number...? You may be potentially affected by this action if you are an agricultural producer, food manufacturer...

  2. 77 FR 1407 - Regulated Navigation Area; Memorial Bridge Construction, Piscataqua River, Portsmouth, NH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ...-AA11 Regulated Navigation Area; Memorial Bridge Construction, Piscataqua River, Portsmouth, NH AGENCY... River under and surrounding the Memorial Bridge between Portsmouth, NH and Kittery, ME. This temporary interim rule is necessary to provide for the safety of life on the navigable waters during bridge...

  3. Interim Closure Activities at Corrective Action Unit 114: Area 25 EMAD Facility, Nevada National Security Site, Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boehlecke, R. F.

    This letter report documents interim activities that have been completed at CAU 114 to support ongoing access and generate information necessary to plan future closure activities. General housekeeping and cleanup of debris was conducted in the EMAD yard, cold bays, support areas of Building 3900, and postmortem cell tunnel area of the hot bay. All non-asbestos ceiling tiles and loose and broken non-friable asbestos floor tiles were removed from support galleries and office areas. Non-radiologically contaminated piping and equipment in the cold areas of the building and in the two 120-ton locomotives in the yard were tapped, characterized, drained, andmore » verified free of contents.« less

  4. Interim Cryogenic Propulsion Stage (ICPS) Transport from DOC to

    NASA Image and Video Library

    2017-07-26

    The Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System (SLS) rocket is packed inside a canister and ready to exit the United Launch Alliance (ULA) Delta Operations Center near Space Launch Complex 37 at Cape Canaveral Air Force Station for its move to the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. It is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission-1.

  5. 76 FR 42686 - DOE Response to Recommendation 2011-1 of the Defense Nuclear Facilities Safety Board, Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... DEPARTMENT OF ENERGY DOE Response to Recommendation 2011-1 of the Defense Nuclear Facilities... Nuclear Facilities Safety Board, Office of Health, Safety and Security, U.S. Department of Energy, 1000... Department of Energy (DOE) acknowledges receipt of Defense Nuclear Facilities Safety Board (Board...

  6. Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.

    PubMed

    Aggarwal, Swati P; Zinman, Lorne; Simpson, Elizabeth; McKinley, Jane; Jackson, Katherine E; Pinto, Hanika; Kaufman, Petra; Conwit, Robin A; Schoenfeld, David; Shefner, Jeremy; Cudkowicz, Merit

    2010-05-01

    In a pilot study, lithium treatment slowed progression of amyotrophic lateral sclerosis (ALS). We aimed to confirm or disprove these findings by assessing the safety and efficacy of lithium in combination with riluzole in patients with ALS. We did a double-blind, placebo-controlled trial with a time-to-event design. Between January and June, 2009, patients with ALS who were taking a stable dose of riluzole for at least 30 days were randomly assigned (1:1) by a centralised computer to receive either lithium or placebo. Patients, caregivers, investigators, and all site study staff with the exception of site pharmacists were masked to treatment assignment. The primary endpoint was the time to an event, defined as a decrease of at least six points on the revised ALS functional rating scale score or death. Interim analyses were planned for when 84 patients had been allocated treatment, 6 months later or after 55 events, and after 100 events. Analysis was by intention to treat. The stopping boundary for futility at the first interim analysis was a p value of at least 0.68. We used a log-rank test to compare the distributions of the time to an event between the lithium and placebo groups. This trial is registered with ClinicalTrials.gov, NCT00818389. At the first interim analysis, 22 of 40 patients in the lithium group had an event compared with 20 of 44 patients in the placebo group (log rank p=0.51). The hazard ratio of reaching the primary endpoint was 1.13 (95% CI 0.61-2.07). The study was stopped at the first interim analysis because criterion for futility was met (p=0.78). The difference in mean decline in the ALS functional rating scale score between the lithium group and the placebo group was 0.15 (95% CI -0.43 to 0.73, p=0.61). There were no major safety concerns. Falls (p=0.04) and back pain (p=0.05) were more common in the lithium group than in the placebo group. We found no evidence that lithium in combination with riluzole slows progression of ALS more than riluzole alone. The time-to-event endpoint and use of prespecified interim analyses enabled a clear result to be obtained rapidly. This design should be considered for future trials testing the therapeutic efficacy of drugs that are easily accessible to people with ALS. National Institute of Neurological Disorders and Stroke, ALS Association, and ALS Society of Canada. Copyright 2010 Elsevier Ltd. All rights reserved.

  7. Butch Wilmore tour of ULA facility and viewing of ICPS

    NASA Image and Video Library

    2017-03-16

    Inside the United Launch Alliance Horizontal Integration Facility at Cape Canaveral Air Force Station in Florida, NASA astronaut Barry "Butch" Wilmore views the first integrated piece of flight hardware for NASA's Space Launch System (SLS) rocket, the Interim Cryogenic Propulsion Stage (ICPS). The ICPS is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission 1.

  8. Experimental validation of depletion calculations with VESTA 2.1.5 using JEFF-3.2

    NASA Astrophysics Data System (ADS)

    Haeck, Wim; Ichou, Raphaëlle

    2017-09-01

    The removal of decay heat is a significant safety concern in nuclear engineering for the operation of a nuclear reactor both in normal and accidental conditions and for intermediate and long term waste storage facilities. The correct evaluation of the decay heat produced by an irradiated material requires first of all the calculation of the composition of the irradiated material by depletion codes such as VESTA 2.1, currently under development at IRSN in France. A set of PWR assembly decay heat measurements performed by the Swedish Central Interim Storage Facility (CLAB) located in Oskarshamm (Sweden) have been calculated using different nuclear data libraries: ENDF/B-VII.0, JEFF-3.1, JEFF-3.2 and JEFF-3.3T1. Using these nuclear data libraries, VESTA 2.1 calculates the assembly decay heat for almost all cases within 4% of the measured decay heat. On average, the ENDF/B-VII.0 calculated decay heat values appear to give a systematic underestimation of only 0.5%. When using the JEFF-3.1 library, this results a systematic underestimation of about 2%. By switching to the JEFF-3.2 library, this systematic underestimation is improved slighty (up to 1.5%). The changes made in the JEFF-3.3T1 beta library appear to be overcorrecting, as the systematic underestimation is transformed into a systematic overestimation of about 1.5%.

  9. 78 FR 69433 - Executive Order 13650 Improving Chemical Facility Safety and Security Listening Sessions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... Chemical Facility Safety and Security Listening Sessions AGENCY: National Protection and Programs... from stakeholders on issues pertaining to Improving Chemical Facility Safety and Security (Executive... regulations, guidance, and policies; and identifying best practices in chemical facility safety and security...

  10. TRICARE; changes included in the National Defense Authorization Act for fiscal year 2005; TRICARE Dental Program. Interim final rule.

    PubMed

    2005-09-21

    The Department is publishing this interim final rule to implement sections 711 and 715 of the Ronald W. Reagan National Defense Authorization Act for Fiscal Year 2005 (NDAA-05), Public Law 108-375. Specifically, that legislation makes young dependents of deceased Service members eligible for enrollment in the TRICARE Dental Program when the child was not previously enrolled because of age, and authorizes post-graduate dental residents in a dental treatment facility of the uniformed services under a graduate dental education program accredited by the American Dental Association to provide dental treatment to dependents who are 12 years of age or younger and who are covered by a dental plan established under 10 U.S.C. 1076a. This rule also corrects certain references in 32 CFR 199.13. The rule is being published as an interim final rule with comment period in order to comply with statutory effective dates. Public comments are invited and will be considered for possible revisions to the final rule.

  11. Interim Consequence Management Guidance for a Wide-Area Biological Attack

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Raber, Ellen; Kirvel, Robert; MacQueen, Don

    2011-05-17

    The Interagency Biological Restoration Demonstration (IBRD) program is a collaborative, interagency effort co-chaired by the Department of Homeland Security and Department of Defense aimed at improving the nation‘s ability to respond to and recover from a large-scale, wide-area, domestic attack involving the release of an environmentally persistent biological warfare agent. The program is focused on understanding interactions between the civilian and military sectors, and in building mutual support to carry out such remediations. This Interim Consequence Management Guidance document provides guidance for decisionmakers in executing activities required to respond to and recover from a biological incident affecting a wide urbanmore » area insofar as information is currently available. The spore-forming bacterium Bacillus anthracis is discussed as the biological agent of primary concern because it is the most difficult of known bioterrorism agents to inactivate and is considered to be one of the key threat agents. Most other biological threat agents are much easier to remediate, and in many cases, inactivation would occur naturally within days as a result of environmental exposure; however, the framework and operational questions that need to be addressed are expected to remain the same. The guidance in this document is applicable to (1) enclosed facilities, such as commercial, residential, and continental U.S. military facilities; (2) semi-enclosed facilities, such as subways and public transit facilities; (3) outdoor areas (both localized and wide area), such as building exteriors, streets, parks, and other open spaces; (4) drinking water facilities; and (5) drinking water sources. This document follows an interagency framework [Planning Guidance for Recovery Following Biological Incidents (DHS and EPA 2009)]—which considered Raber et al. (2002) in its development—but takes the framework to a more operational level and provides guidance at key action and decision points.« less

  12. Establishing a store baseline during interim storage of waste packages and a review of potential technologies for base-lining

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McTeer, Jennifer; Morris, Jenny; Wickham, Stephen

    Interim storage is an essential component of the waste management lifecycle, providing a safe, secure environment for waste packages awaiting final disposal. In order to be able to monitor and detect change or degradation of the waste packages, storage building or equipment, it is necessary to know the original condition of these components (the 'waste storage system'). This paper presents an approach to establishing the baseline for a waste-storage system, and provides guidance on the selection and implementation of potential base-lining technologies. The approach is made up of two sections; assessment of base-lining needs and definition of base-lining approach. Duringmore » the assessment of base-lining needs a review of available monitoring data and store/package records should be undertaken (if the store is operational). Evolutionary processes (affecting safety functions), and their corresponding indicators, that can be measured to provide a baseline for the waste-storage system should then be identified in order for the most suitable indicators to be selected for base-lining. In defining the approach, identification of opportunities to collect data and constraints is undertaken before selecting the techniques for base-lining and developing a base-lining plan. Base-lining data may be used to establish that the state of the packages is consistent with the waste acceptance criteria for the storage facility and to support the interpretation of monitoring and inspection data collected during store operations. Opportunities and constraints are identified for different store and package types. Technologies that could potentially be used to measure baseline indicators are also reviewed. (authors)« less

  13. 77 FR 51943 - Procedures for Safety Investigations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1708 Procedures for Safety Investigations AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Proposed rule; extension of comment period. SUMMARY: The Defense Nuclear Facilities Safety Board is extending the time for comments on its proposed...

  14. Juvenile Residential Facility Census, 2010: Selected Findings. Juvenile Offenders and Victims: National Report Series. Bulletin NCJ 241134

    ERIC Educational Resources Information Center

    Hockenberry, Sarah; Sickmund, Melissa; Sladky, Anthony

    2013-01-01

    This bulletin is part of the "Juvenile Offenders and Victims National Report Series." The "National Report" offers a comprehensive statistical overview of the problems of juvenile crime, violence, and victimization and the response of the juvenile justice system. During each interim year, the bulletins in the "National…

  15. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service Pt. 124, Subpt. G... the area. 6. The availability of resources (including health manpower, management personnel, and funds... alternative uses of such resources for the provision of other health services. 7. The special needs and...

  16. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service Pt. 124, Subpt. G... the area. 6. The availability of resources (including health manpower, management personnel, and funds... alternative uses of such resources for the provision of other health services. 7. The special needs and...

  17. 42 CFR Appendix to Subpart G of... - Interim Procedures and Criteria for Review by Health Systems Agencies of Applications Under...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RESOURCES DEVELOPMENT MEDICAL FACILITY CONSTRUCTION AND MODERNIZATION Community Service Pt. 124, Subpt. G... the area. 6. The availability of resources (including health manpower, management personnel, and funds... alternative uses of such resources for the provision of other health services. 7. The special needs and...

  18. 78 FR 12042 - Public Availability of Defense Nuclear Facilities Safety Board FY 2011 Service Contract Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Public Availability of Defense Nuclear Facilities Safety Board FY 2011 Service Contract Inventory Analysis/FY 2012 Service Contract Inventory AGENCY: Defense Nuclear Facilities Safety Board (DNFSB). ACTION: Notice of Public Availability of FY 2011 Service Contract...

  19. 76 FR 5354 - Public Availability of Defense Nuclear Facilities Safety Board FY 2010 Service Contract Inventory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Public Availability of Defense Nuclear Facilities Safety Board FY 2010 Service Contract Inventory AGENCY: Defense Nuclear Facilities Safety Board (Board). ACTION: Notice of public availability of FY 2010 Service Contract Inventories. SUMMARY: In accordance with...

  20. 77 FR 7139 - Public Availability of Defense Nuclear Facilities Safety Board; FY 2010 Service Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Public Availability of Defense Nuclear Facilities Safety Board; FY 2010 Service Contract Inventory Analysis/FY 2011 Service Contract Inventory AGENCY: Defense Nuclear Facilities Safety Board (DNFSB). ACTION: Notice of Public Availability of FY 2010 Service Contract...

  1. Creating a Platform for Sustained Neighborhood Improvement: Interim Findings from Chicago's New Communities Program

    ERIC Educational Resources Information Center

    Greenberg, David; Verma, Nandita; Dillman, Keri-Nicole; Chaskin, Robert

    2010-01-01

    Distressed urban neighborhoods face challenges on multiple fronts, but most efforts to confront these problems work in isolation of one another. The New Communities Program (NCP) is an exception, helping selected Chicago neighborhoods develop partnerships to address challenges involving employment, education, housing, and safety in a…

  2. 75 FR 37452 - Science Board Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-N-0001... Safety and Applied Nutrition (CFSAN). The Science Board will hear about an interim report from the... the committee. Written submissions may be made to the contact person on or before August 9, 2010. Oral...

  3. 49 CFR 229.133 - Interim locomotive conspicuity measures-auxiliary external lights.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... incorporate a device that automatically extinguishes the white light if display of a light of another color is... display of a light of another color is required to protect the safety of railroad operations. (c)(1) Any... external lights. 229.133 Section 229.133 Transportation Other Regulations Relating to Transportation...

  4. 49 CFR 229.133 - Interim locomotive conspicuity measures-auxiliary external lights.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... incorporate a device that automatically extinguishes the white light if display of a light of another color is... display of a light of another color is required to protect the safety of railroad operations. (c)(1) Any... external lights. 229.133 Section 229.133 Transportation Other Regulations Relating to Transportation...

  5. 49 CFR 229.133 - Interim locomotive conspicuity measures-auxiliary external lights.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... incorporate a device that automatically extinguishes the white light if display of a light of another color is... display of a light of another color is required to protect the safety of railroad operations. (c)(1) Any... external lights. 229.133 Section 229.133 Transportation Other Regulations Relating to Transportation...

  6. 16 CFR 1203.53 - Interim safety standards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Protective Headgear for Bicyclists, (2) ASTM standards F 1447-93 or F 1447-94, Standard Specification for Protective Headgear Used in Bicycling, incorporating the relevant provisions of ASTM F 1446-93 or ASTM F 1446... Institute, 11 W. 42nd Street, 13th Floor, New York, NY 10036. Copies of the ASTM standards are available...

  7. 78 FR 14314 - Towing Safety Advisory Committee; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Regarding Manning of Inspected Towing Vessels. On March 21, 2013 from 8 a.m. to 5:30 p.m. and on March 22... Vessels. An interim report will be given. (7) Recommendations regarding Manning of Inspected Towing...) Recommendations for the Standardization of Tug/Towboat Definitions, and; (3) Recommendations for Wake and Surge...

  8. Exploring approaches to the administration of a long-term care facility: The application of a community planning and development process.

    PubMed

    Caldwell, W J

    1996-01-01

    This article outlines the approaches taken to the management of two long-term care facilities by the County of Huron in southwestern Ontario in 1994. Lay-offs, a move to new facilities, loss of local political confidence, changes in key administrative personnel and low staff morale prompted the county to ask an interim administrative team to develop and implement an appropriate response. The article explains how community development and planning principles and techniques were applied to the management of the homes to achieve an overall improvement in communication, staff morale and attitude. These approaches may prove helpful to other administrations facing major change.

  9. Guide for Maintaining Pedestrian Facilities for Enhanced Safety.

    DOT National Transportation Integrated Search

    2013-10-01

    A Guide for Maintaining Pedestrian Facilities for Enhanced Safety provides guidance for maintaining pedestrian facilities with the primary goal of increasing safety and mobility. The Guide addresses the needs for pedestrian facility maintenance; comm...

  10. Revised ground-water monitoring compliance plan for the 300 area process trenches

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schalla, R.; Aaberg, R.L.; Bates, D.J.

    1988-09-01

    This document contains ground-water monitoring plans for process-water disposal trenches located on the Hanford Site. These trenches, designated the 300 Area Process Trenches, have been used since 1973 for disposal of water that contains small quantities of both chemicals and radionuclides. The ground-water monitoring plans contained herein represent revision and expansion of an effort initiated in June 1985. At that time, a facility-specific monitoring program was implemented at the 300 Area Process Trenches as part of a regulatory compliance effort for hazardous chemicals being conducted on the Hanford Site. This monitoring program was based on the ground-water monitoring requirements formore » interim-status facilities, which are those facilities that do not yet have final permits, but are authorized to continue interim operations while engaged in the permitting process. The applicable monitoring requirements are described in the Resource Conservation and Recovery Act (RCRA), 40 CFR 265.90 of the federal regulations, and in WAC 173-303-400 of Washington State's regulations (Washington State Department of Ecology 1986). The program implemented for the process trenches was designed to be an alternate program, which is required instead of the standard detection program when a facility is known or suspected to have contaminated the ground water in the uppermost aquifer. The plans for the program, contained in a document prepared by the US Department of Energy (USDOE) in 1985, called for monthly sampling of 14 of the 37 existing monitoring wells at the 300 Area plus the installation and sampling of 2 new wells. 27 refs., 25 figs., 15 tabs.« less

  11. Disposition of fuel elements from the Aberdeen and Sandia pulse reactor (SPR-II) assemblies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mckerley, Bill; Bustamante, Jacqueline M; Costa, David A

    2010-01-01

    We describe the disposition of fuel from the Aberdeen (APR) and the Sandia Pulse Reactors (SPR-II) which were used to provide intense neutron bursts for radiation effects testing. The enriched Uranium - 10% Molybdenum fuel from these reactors was shipped to the Los Alamos National Laboratory (LANL) for size reduction prior to shipment to the Savannah River Site (SRS) for final disposition in the H Canyon facility. The Shipper/Receiver Agreements (SRA), intra-DOE interfaces, criticality safety evaluations, safety and quality requirements and key materials management issues required for the successful completion of this project will be presented. This work is inmore » support of the DOE Consolidation and Disposition program. Sandia National Laboratories (SNL) has operated pulse nuclear reactor research facilities for the Department of Energy since 1961. The Sandia Pulse Reactor (SPR-II) was a bare metal Godiva-type reactor. The reactor facilities have been used for research and development of nuclear and non-nuclear weapon systems, advanced nuclear reactors, reactor safety, simulation sources and energy related programs. The SPR-II was a fast burst reactor, designed and constructed by SNL that became operational in 1967. The SPR-ll core was a solid-metal fuel enriched to 93% {sup 235}U. The uranium was alloyed with 10 weight percent molybdenum to ensure the phase stabilization of the fuel. The core consisted of six fuel plates divided into two assemblies of three plates each. Figure 1 shows a cutaway diagram of the SPR-II Reactor with its decoupling shroud. NNSA charged Sandia with removing its category 1 and 2 special nuclear material by the end of 2008. The main impetus for this activity was based on NNSA Administrator Tom D'Agostino's six focus areas to reenergize NNSA's nuclear material consolidation and disposition efforts. For example, the removal of SPR-II from SNL to DAF was part of this undertaking. This project was in support of NNSA's efforts to consolidate the locations of special nuclear material (SNM) to reduce the cost of securing many SNM facilities. The removal of SPR-II from SNL was a significant accomplishment in SNL's de-inventory efforts and played a key role in reducing the number of locations requiring the expensive security measures required for category 1 and 2 SNM facilities. A similar pulse reactor was fabricated at the Y-12 National Security Complex beginning in the late 1960's. This Aberdeen Pulse Reactor (APR) was operated at the Army Pulse Radiation Facility (APRF) located at the Aberdeen Test Center (ATC) in Maryland. When the APRF was shut down in 2003, a portion of the DOE-owned Special Nuclear Material (SNM) was shipped to an interim facility for storage. Subsequently, the DOE determined that the material from both the SPR-II and the APR would be processed in the H-Canyon at the Savannah River Site (SRS). Because of the SRS receipt requirements some of the material was sent to the Los Alamos National Laboratory (LANL) for size-reduction prior to shipment to the SRS for final disposition.« less

  12. Japanese study of tofogliflozin with type 2 diabetes mellitus patients in an observational study of the elderly (J-STEP/EL): A 12-week interim analysis.

    PubMed

    Utsunomiya, Kazunori; Shimmoto, Naoki; Senda, Masayuki; Kurihara, Yuji; Gunji, Ryoji; Kameda, Hiroyuki; Tamura, Masahiro; Mihara, Hanako; Kaku, Kohei

    2016-09-01

    Sodium-glucose co-transporter 2 inhibitors are a promising treatment for type 2 diabetes mellitus, but are associated with concerns about specific adverse drug reactions. We carried out a 1-year post-marketing surveillance of tofogliflozin, a novel agent in this class, in Japanese elderly patients with type 2 diabetes mellitus and here report the results of a 12-week interim analysis, focusing on adverse drug reactions of special interest. The present prospective observational study included all type 2 diabetes mellitus patients aged ≥65 years who started tofogliflozin during the first 3 months after its launch. Data on demographic and baseline characteristics, clinical course and adverse events were collected. Of 1,535 patients registered, 1,506 patients whose electronic case report forms were collected and who had at least one follow-up visit were included in the safety analysis at 12 weeks. A total of 178 of 1,506 patients (11.82%) had at least one adverse drug reaction to tofogliflozin. The incidence of adverse drug reactions of special interest (polyuria/pollakiuria, volume depletion-related events, urinary tract infection, genital infection, skin disorders and hypoglycemia) was 2.19, 2.32, 1.33, 1.13, 1.46 and 0.73%, respectively. No new safety concerns were identified. Among those evaluable for clinical effectiveness, the mean (standard deviation) glycated hemoglobin decreased from 7.65% (1.35%) at baseline to 7.25% (1.16%) at 12 weeks by 0.39% (0.94%; P < 0.0001). This interim analysis characterized the safety profile of tofogliflozin in Japanese elderly patients with type 2 diabetes mellitus during the early post-marketing period. © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

  13. 76 FR 26716 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting AGENCY: Defense Nuclear Facilities... Defense Nuclear Facilities Safety Board's (Board) public meeting and hearing. FEDERAL REGISTER CITATIONS... Defense Nuclear Facilities Safety Board, Public Hearing Room, 625 Indiana Avenue, NW., Suite 300...

  14. Procedures for the handling of retaliation complaints under section 1558 of the Affordable Care Act. Interim final rule; request for comments.

    PubMed

    2013-02-27

    This document provides the interim final regulations governing the employee protection (whistleblower) provision of section 1558 of the Affordable Care Act, which added section 18C of the Fair Labor Standards Act, to provide protections to employees of health insurance issuers or other employers who may have been subject to retaliation for reporting potential violations of the law's consumer protections (e.g., the prohibition on denials of insurance due to pre-existing conditions) or affordability assistance provisions (e.g., access to health insurance premium tax credits). This interim rule establishes procedures and time frames for the handling of retaliation complaints under section 18C, including procedures and time frames for employee complaints to the Occupational Safety and Health Administration (OSHA), investigations by OSHA, appeals of OSHA determinations to an administrative law judge (ALJ) for a hearing de novo, hearings by ALJs, review of ALJ decisions by the Administrative Review Board (ARB) (acting on behalf of the Secretary of Labor), and judicial review of the Secretary's final decision.

  15. Progress and future direction for the interim safe storage and disposal of Hanford high-level waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kinzer, J.E.; Wodrich, D.D.; Bacon, R.F.

    This paper describes the progress made at the largest environmental cleanup program in the United States. Substantial advances in methods to start interim safe storage of Hanford Site high-level wastes, waste characterization to support both safety- and disposal-related information needs, and proceeding with cost-effective disposal by the U.S. Department of Energy (DOE) and its Hanford Site contractors, have been realized. Challenges facing the Tank Waste Remediation System (TWRS) Program, which is charged with the dual and parallel missions of interim safe storage and disposal of the high-level tank waste stored at the Hanford Site, are described. In these times ofmore » budget austerity, implementing an ongoing program that combines technical excellence and cost effectiveness is the near-term challenge. The technical initiatives and progress described in this paper are made more cost effective by DOE`s focus on work force productivity improvement, reduction of overhead costs, and reduction, integration and simplification of DOE regulations and operations requirements to more closely model those used in the private sector.« less

  16. Mapping the Risks. Assessing the Homeland Security Implications of Publicly Available Geospatial Information

    DTIC Science & Technology

    2004-01-01

    Defense Nuclear Facilities Safety Board 1 0.2 Export-Import Bank 1 0.2 National Archives and Records Administration 1 0.2 Supreme Court of the United...Agency Commodity Futures Trading Commission Consumer Product Safety Commission Defense Nuclear Facilities Safety Board Environmental Protection Agency...Intelligence www.cia.gov Defense Nuclear Facilities Safety Board Defense Nuclear Facilities Safety Board www.dnfsb.gov Department of

  17. 75 FR 74022 - Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD [Recommendation 2010-1] Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers AGENCY: Defense Nuclear Facilities Safety Board... Nuclear Facilities Safety Board has made a recommendation to the Secretary of Energy requesting an...

  18. 75 FR 56080 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... Facilities Safety Board's public hearing and meeting. FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT: 75... INFORMATION: Brian Grosner, General Manager, Defense Nuclear Facilities Safety Board, 625 Indiana Avenue, NW...

  19. 78 FR 4393 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... given of the Defense Nuclear Facilities Safety Board's (Board) public meeting and hearing described... Session II, the Board will receive testimony concerning safety at Pantex defense nuclear facilities. The...

  20. Facility safety study

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The safety of NASA's in house microelectronics facility is addressed. Industrial health standards, facility emission control requirements, operation and safety checklists, and the disposal of epitaxial vent gas are considered.

  1. 77 FR 479 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... of the Defense Nuclear Facilities Safety Board's (Board) public hearing and meeting described below... Nuclear Facilities Safety Board, 625 Indiana Avenue NW., Suite 700, Washington, DC 20004-2901, (800) 788...

  2. 77 FR 48970 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... given of the Defense Nuclear Facilities Safety Board's (Board) public meeting and hearing described... (NNSA) efforts to mitigate risks to public and worker safety posed by aging defense nuclear facilities...

  3. 78 FR 48201 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2013-01; Guidance for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... following the earthquake and shutdown of the operating units, however, the first large tsunami wave inundated the site, followed by additional waves. The tsunami caused extensive damage to site facilities and..., and after some period of time at the other units. Unit 6 retained the function of one air-cooled EDG...

  4. 78 FR 3039 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-06; Performing a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... following the earthquake and shutdown of the operating units, however, the first large tsunami wave inundated the site, followed by additional waves. The tsunami caused extensive damage to site facilities and..., and after some period of time at the other units. Unit 6 retained the function of one air-cooled EDG...

  5. 78 FR 35984 - Interim Eligible Class of NRC-Licensed Facilities; Docket Nos. (as Shown in Attachment 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... consisting of a fingerprint-based background check against applicable Federal Bureau of Investigation (FBI... completed hard-copy FBI Form FD- 258, ``Fingerprint Card,'' to the NRC as specified in Attachment 3, for all... Section 161A.b. shall be subject to a background check by the Attorney General, based on fingerprints and...

  6. School Capital Manual. An Interim Guide for School Boards, Administrators, Facility Planners and Consultants Who Engage in School Building Projects.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton.

    This manual is intended for use by the Alberta, Canada, school boards, administrators, consultants, education staff, and other individuals involved in school building projects. The purpose of the School Capital Plan, funding, and Alberta Education's funding framework are detailed. The school building project components of the School Capital Plan…

  7. MFTF-. cap alpha. + T progress report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, W.D.

    1985-04-01

    Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; theymore » will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.« less

  8. 78 FR 9902 - DOE Response to Recommendation 2012-2 of the Defense Nuclear Facilities Safety Board, Hanford...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... DEPARTMENT OF ENERGY DOE Response to Recommendation 2012-2 of the Defense Nuclear Facilities Safety Board, Hanford Tank Farms Flammable Gas Safety Strategy; Correction AGENCY: Department of Energy... Facilities Safety Board, Hanford Tank Farms Flammable Gas Safety Strategy. This document corrects an error in...

  9. 75 FR 69648 - Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD [Recommendation 2010-1] Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers AGENCY: Defense Nuclear Facilities Safety Board... Facilities Safety Board has made a recommendation to the Secretary of Energy requesting an amendment to the...

  10. 75 FR 53353 - Notice of Availability of Final Interim Staff Guidance Document No. 25 “Pressure and Helium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... Guidance Document No. 25 ``Pressure and Helium Leakage Testing of the Confinement Boundary of Spent Fuel...: The Division of Spent Fuel Storage and Transportation (SFST) of the Office of Nuclear Materials Safety... Helium Leakage Testing of the Confinement Boundary of Spent Fuel Dry Storage Systems.'' This ISG...

  11. Production Guides for Vegetable Entrees, Soups, Desserts, Pastries and Salads Developed for Use in Central Food Preparation Facilities. Fort Lee, Interim Facility

    DTIC Science & Technology

    1974-09-01

    mately l£ hours or until double in bulk. After fermentation, turn out dough onto a floured table. Divide and make up as desired. Cookies 1. When... cookies can be deposited on sheet pans by pastry bag. If a cookie depositer is used, the stiffness of the dough can be controlled by adjusting the...10 pieces, each weighing about 1 lb (1*53-6 g). Form each piece into a roll and cut into 20 slices. 3. Place cookie dough in rows 5 x 7 on greased

  12. Orion Stage Adapter Arrival

    NASA Image and Video Library

    2018-04-03

    NASA's Super Guppy aircraft touches down at the Shuttle Landing Facility at the agency's Kennedy Space Center in Florida. The Super Guppy is carrying the Orion Stage Adapter (OSA), the second flight-hardware section of NASA's Space Launch System (SLS) rocket that has arrived at Kennedy. The OSA will connect the Orion spacecraft to the upper part of the SLS rocket, the interim cryogenic propulsion stage (ICPS). Both the OSA and ICPS are being stored for processing in the center's Space Station Processing Facility in preparation for Exploration Mission-1, the first uncrewed, integrated launch of the SLS rocket and Orion spacecraft.

  13. Orion Stage Adapter Arrival

    NASA Image and Video Library

    2018-04-03

    NASA's Super Guppy aircraft taxies onto the tarmac after touching down at the Shuttle Landing Facility at the agency's Kennedy Space Center in Florida. The Super Guppy is carrying the Orion Stage Adapter (OSA), the second flight-hardware section of NASA's Space Launch System (SLS) rocket that has arrived at Kennedy. The OSA will connect the Orion spacecraft to the upper part of the SLS rocket, the interim cryogenic propulsion stage (ICPS). Both the OSA and ICPS are being stored for processing in the center's Space Station Processing Facility in preparation for Exploration Mission-1, the first uncrewed, integrated launch of the SLS rocket and Orion spacecraft.

  14. Orion Stage Adapter Arrival

    NASA Image and Video Library

    2018-04-03

    NASA's Super Guppy aircraft glides to a stop at the Shuttle Landing Facility at the agency's Kennedy Space Center in Florida. The Super Guppy is carrying the Orion Stage Adapter (OSA), the second flight-hardware section of NASA's Space Launch System (SLS) rocket that has arrived at Kennedy. The OSA will connect the Orion spacecraft to the upper part of the SLS rocket, the interim cryogenic propulsion stage (ICPS). Both the OSA and ICPS are being stored for processing in the center's Space Station Processing Facility in preparation for Exploration Mission-1, the first uncrewed, integrated launch of the SLS rocket and Orion spacecraft.

  15. Orion Stage Adapter Arrival

    NASA Image and Video Library

    2018-04-03

    NASA's Super Guppy aircraft prepares to touch down at the Shuttle Landing Facility at the agency's Kennedy Space Center in Florida. The Super Guppy is carrying the Orion Stage Adapter (OSA), the second flight-hardware section of NASA's Space Launch System (SLS) rocket that has arrived at Kennedy. The OSA will connect the Orion spacecraft to the upper part of the SLS rocket, the interim cryogenic propulsion stage (ICPS). Both the OSA and ICPS are being stored for processing in the center's Space Station Processing Facility in preparation for Exploration Mission-1, the first uncrewed, integrated launch of the SLS rocket and Orion spacecraft.

  16. (US low-level radioactive waste management facility design, construction, and operation): Foreign trip report, July 22--30, 1989

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Van Hoesen, S.D.; Bolinsky, J.

    1989-08-02

    The Martin Marietta Energy Systems, Inc., Team, consisting of representatives of the Engineering Division and Oak Ridge National Laboratory (ORNL), participated in a technology exchange program on French and US low-level radioactive waste (LLW) management facility design, construction, and operation. Meetings were held at the Agence National pour la Gestion des Dechets Radioactif (ANDRA) offices in Paris to review the designs for the new French LLW disposal facility, the Cente de Stockage de l'Aube (CSA), and the new ORNL LLW disposal project, the Interim Waste Management Facility (IWMF), and the results of the French LLW disposal facility cover experiment atmore » St. Sauveur. Visits were made to the operating LLW disposal facility, the Centre de Stockage de la Manche (CSM), the LLW conditioning facilities at the La Hague Reprocessing Facility, and the St. Saueveur Disposal Cap Experiment to discuss design, construction, and operating experience. A visit was also made to the CSA site to view the progress made in construction of the new facility.« less

  17. 78 FR 48029 - Improving Chemical Facility Safety and Security

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... responding to risks in chemical facilities (including during pre-inspection, inspection execution, post.... Sec. 2. Establishment of the Chemical Facility Safety and Security Working Group. (a) There is established a Chemical Facility Safety and Security Working Group (Working Group) co-chaired by the Secretary...

  18. Safety and effectiveness of certolizumab pegol in patients with rheumatoid arthritis: Interim analysis of post-marketing surveillance.

    PubMed

    Kameda, Hideto; Nishida, Keiichiro; Nannki, Toshihiro; Watanabe, Akira; Oshima, Yukiya; Momohara, Shigaki

    2017-01-01

    Objective: To evaluate the safety and effectiveness of certolizumab pegol (CZP) in a real-world setting among Japanese patients with rheumatoid arthritis. Post-marketing surveillance data from 2,579 patients treated with CZP were analyzed. Adverse events (AEs) observed during the 24-week CZP treatment period were recorded. Disease activity was evaluated using DAS28-ESR and DAS28-CRP at baseline, Week 12, Week 24, or at withdrawal. The total period of exposure to CZP was 1313.8 patient-years (PY). AEs were reported in 658 (25.5%) patients, at an event rate (ER) of 73.68/100 PY. The most frequent serious AEs were pneumonia, herpes zoster, and interstitial lung disease, at ER per 100 PY of 2.06, 1.29, and 1.22, respectively. Mean disease activity scores at baseline, as measured by DAS28-ESR and DAS28-CRP, were 4.77 ± 1.34 and 4.21 ± 1.27, respectively. Mean changes from baseline at the last observation were -1.29 ± 1.46 and -1.30 ± 1.42, respectively. EULAR good or moderate responses were achieved in 65% of patients. Longer disease duration, prior biologics use, and treatment without MTX co-therapy were associated with EULAR no response. In this interim analysis, no new safety signals were observed. Clinical response to CZP was observed in approximately two thirds of patients.

  19. 75 FR 13433 - Safety Zone; Invista Inc Facility Docks, Victoria Barge Canal, Victoria, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ...-AA00 Safety Zone; Invista Inc Facility Docks, Victoria Barge Canal, Victoria, TX AGENCY: Coast Guard... safety zone for a partial blockage of the Victoria Barge Canal when the Invista Inc facility is... channel will be substantially reduced. The safety zone is necessary to help ensure the safety of the...

  20. Health and Safety Management for Small-scale Methane Fermentation Facilities

    NASA Astrophysics Data System (ADS)

    Yamaoka, Masaru; Yuyama, Yoshito; Nakamura, Masato; Oritate, Fumiko

    In this study, we considered health and safety management for small-scale methane fermentation facilities that treat 2-5 ton of biomass daily based on several years operation experience with an approximate capacity of 5 t·d-1. We also took account of existing knowledge, related laws and regulations. There are no qualifications or licenses required for management and operation of small-scale methane fermentation facilities, even though rural sewerage facilities with a relative similar function are required to obtain a legitimate license. Therefore, there are wide variations in health and safety consciousness of the operators of small-scale methane fermentation facilities. The industrial safety and health laws are not applied to the operation of small-scale methane fermentation facilities. However, in order to safely operate a small-scale methane fermentation facility, the occupational safety and health management system that the law recommends should be applied. The aims of this paper are to clarify the risk factors in small-scale methane fermentation facilities and encourage planning, design and operation of facilities based on health and safety management.

  1. 78 FR 70858 - Safety Zones; Pacific Northwest Grain Handlers Association Facilities; Columbia and Willamette...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... 1625-AA00 Safety Zones; Pacific Northwest Grain Handlers Association Facilities; Columbia and... establishing temporary safety zones around the following Pacific Northwest Grain Handlers Association... Commodities facility on the Willamette River in Portland, OR. These safety zones extend approximately between...

  2. Overview of Energy Systems` safety analysis report programs. Safety Analysis Report Update Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-03-01

    The primary purpose of an Safety Analysis Report (SAR) is to provide a basis for judging the adequacy of a facility`s safety. The SAR documents the safety analyses that systematically identify the hazards posed by the facility, analyze the consequences and risk of potential accidents, and describe hazard control measures that protect the health and safety of the public and employees. In addition, some SARs document, as Technical Safety Requirements (TSRs, which include Technical Specifications and Operational Safety Requirements), technical and administrative requirements that ensure the facility is operated within prescribed safety limits. SARs also provide conveniently summarized information thatmore » may be used to support procedure development, training, inspections, and other activities necessary to facility operation. This ``Overview of Energy Systems Safety Analysis Report Programs`` Provides an introduction to the programs and processes used in the development and maintenance of the SARs. It also summarizes some of the uses of the SARs within Energy Systems and DOE.« less

  3. Make safety awareness a priority: Use a login software in your research facility

    DOE PAGES

    Camino, Fernando E.

    2017-01-21

    We report on a facility login software, whose objective is to improve safety in multi-user research facilities. Its most important safety features are: 1) blocks users from entering the lab after being absent for more than a predetermined number of days; 2) gives users a random safety quiz question, which they need to answer satisfactorily in order to use the facility; 3) blocks unauthorized users from using the facility afterhours; and 4) displays the current users in the facility. Besides restricting access to unauthorized users, the software keeps users mindful of key safety concepts. In addition, integration of the softwaremore » with a door controller system can convert it into an effective physical safety mechanism. Depending on DOE approval, the code may be available as open source.« less

  4. Make safety awareness a priority: Use a login software in your research facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Camino, Fernando E.

    We report on a facility login software, whose objective is to improve safety in multi-user research facilities. Its most important safety features are: 1) blocks users from entering the lab after being absent for more than a predetermined number of days; 2) gives users a random safety quiz question, which they need to answer satisfactorily in order to use the facility; 3) blocks unauthorized users from using the facility afterhours; and 4) displays the current users in the facility. Besides restricting access to unauthorized users, the software keeps users mindful of key safety concepts. In addition, integration of the softwaremore » with a door controller system can convert it into an effective physical safety mechanism. Depending on DOE approval, the code may be available as open source.« less

  5. Functional safety for the Advanced Technology Solar Telescope

    NASA Astrophysics Data System (ADS)

    Bulau, Scott; Williams, Timothy R.

    2012-09-01

    Since inception, the Advanced Technology Solar Telescope (ATST) has planned to implement a facility-wide functional safety system to protect personnel from harm and prevent damage to the facility or environment. The ATST will deploy an integrated safety-related control system (SRCS) to achieve functional safety throughout the facility rather than relying on individual facility subsystems to provide safety functions on an ad hoc basis. The Global Interlock System (GIS) is an independent, distributed, facility-wide, safety-related control system, comprised of commercial off-the-shelf (COTS) programmable controllers that monitor, evaluate, and control hazardous energy and conditions throughout the facility that arise during operation and maintenance. The GIS has been designed to utilize recent advances in technology for functional safety plus revised national and international standards that allow for a distributed architecture using programmable controllers over a local area network instead of traditional hard-wired safety functions, while providing an equivalent or even greater level of safety. Programmable controllers provide an ideal platform for controlling the often complex interrelationships between subsystems in a modern astronomical facility, such as the ATST. A large, complex hard-wired relay control system is no longer needed. This type of system also offers greater flexibility during development and integration in addition to providing for expanded capability into the future. The GIS features fault detection, self-diagnostics, and redundant communications that will lead to decreased maintenance time and increased availability of the facility.

  6. 78 FR 4404 - DOE Response to Recommendation 2012-2 of the Defense Nuclear Facilities Safety Board, Hanford...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... DEPARTMENT OF ENERGY DOE Response to Recommendation 2012-2 of the Defense Nuclear Facilities Safety Board, Hanford Tank Farms Flammable Gas Safety Strategy AGENCY: Department of Energy. ACTION: Notice. SUMMARY: On September 28, 2012 the Defense Nuclear Facilities Safety Board submitted...

  7. Maywood interim storage site. Annual site environmental report, calendar year 1985

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1986-05-01

    During 1985, the environmental monitoring program was continued at the Maywood Interim Storage Site (MISS), a US Department of Energy (DOE) facility located in the Borough of Maywood and the Township of Rochelle Park, New Jersey. The MISS is presently used for the storage of low-level radioactively contaminated soils. Monitoring results show that the MISS is in compliance with DOE concentration guides and radiation protection standards. Derived Concentration Guides (DCGs) represent the concentrations of radionuclides in air or water that would limit the radiation dose to 100 mrem/yr. The applicable guides have been revised since the 1984 environmental monitoring reportmore » was published. The guides applied in 1984 were based on a radiation protection standard of 500 mrem/yr; the guides applied for 1985 are based on a standard of 100 mrem/yr.« less

  8. The Organization and Management of the Nuclear Weapons Program.

    DTIC Science & Technology

    1997-03-01

    over operations include the Defense Nuclear Facilities Safety Board, the Environmental Protection Agency, the Occupational Safety and Health...Safety, and Health. Still more guidance is received from the Defense Nuclear Facilities Safety Board and other external bodies such as the...state regulatory agencies, and the Defense Nuclear Facilities Safety Board. This chapter briefly reviews the most recent decade of this history, describes

  9. 77 FR 33779 - Interim Staff Guidance JLD-ISG-2012-01; Compliance With Order EA-12-049, Order Modifying Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ..., estimated to have exceeded 14 meters (45 feet) in height that inundated the Fukushima Dai-ichi nuclear power... earthquake occurred, Fukushima Dai-ichi Units 1, 2, and 3, were in operation and Units 4, 5, and 6, were shut... facility response to the earthquake appears to have been normal. Following the events at the Fukushima Dai...

  10. Functional Analysis and Preliminary Specifications for a Single Integrated Central Computer System for Secondary Schools and Junior Colleges. Interim Report.

    ERIC Educational Resources Information Center

    1968

    The present report proposes a central computing facility and presents the preliminary specifications for such a system. It is based, in part, on the results of earlier studies by two previous contractors on behalf of the U.S. Office of Education. The recommendations are based upon the present contractors considered evaluation of the earlier…

  11. Variations in return value estimate of ocean surface waves - a study based on measured buoy data and ERA-Interim reanalysis data

    NASA Astrophysics Data System (ADS)

    Muhammed Naseef, T.; Sanil Kumar, V.

    2017-10-01

    An assessment of extreme wave characteristics during the design of marine facilities not only helps to ensure their safety but also assess the economic aspects. In this study, return levels of significant wave height (Hs) for different periods are estimated using the generalized extreme value distribution (GEV) and generalized Pareto distribution (GPD) based on the Waverider buoy data spanning 8 years and the ERA-Interim reanalysis data spanning 38 years. The analysis is carried out for wind-sea, swell and total Hs separately for buoy data. Seasonality of the prevailing wave climate is also considered in the analysis to provide return levels for short-term activities in the location. The study shows that the initial distribution method (IDM) underestimates return levels compared to GPD. The maximum return levels estimated by the GPD corresponding to 100 years are 5.10 m for the monsoon season (JJAS), 2.66 m for the pre-monsoon season (FMAM) and 4.28 m for the post-monsoon season (ONDJ). The intercomparison of return levels by block maxima (annual, seasonal and monthly maxima) and the r-largest method for GEV theory shows that the maximum return level for 100 years is 7.20 m in the r-largest series followed by monthly maxima (6.02 m) and annual maxima (AM) (5.66 m) series. The analysis is also carried out to understand the sensitivity of the number of observations for the GEV annual maxima estimates. It indicates that the variations in the standard deviation of the series caused by changes in the number of observations are positively correlated with the return level estimates. The 100-year return level results of Hs using the GEV method are comparable for short-term (2008 to 2016) buoy data (4.18 m) and long-term (1979 to 2016) ERA-Interim shallow data (4.39 m). The 6 h interval data tend to miss high values of Hs, and hence there is a significant difference in the 100-year return level Hs obtained using 6 h interval data compared to data at 0.5 h interval. The study shows that a single storm can cause a large difference in the 100-year Hs value.

  12. Launch Services Safety Overview

    NASA Technical Reports Server (NTRS)

    Loftin, Charles E.

    2008-01-01

    NASA/KSC Launch Services Division Safety (SA-D) services include: (1) Assessing the safety of the launch vehicle (2) Assessing the safety of NASA ELV spacecraft (S/C) / launch vehicle (LV) interfaces (3) Assessing the safety of spacecraft processing to ensure resource protection of: - KSC facilities - KSC VAFB facilities - KSC controlled property - Other NASA assets (4) NASA personnel safety (5) Interfacing with payload organizations to review spacecraft for adequate safety implementation and compliance for integrated activities (6) Assisting in the integration of safety activities between the payload, launch vehicle, and processing facilities

  13. A prospective trial for laparoscopic adjustable gastric banding in morbidly obese adolescents: an interim report of weight loss, metabolic and quality of life outcomes.

    USDA-ARS?s Scientific Manuscript database

    The outcome of patients completing 12 months of follow-up in a prospective longitudinal trial of the safety/efficacy of laparoscopic adjustable gastric banding (LAGB), for morbidly obese adolescents aged 14 to 17 years using a Food and Drug Administration Institutional Device Exemption for the use o...

  14. 76 FR 58846 - Final Interim Staff Guidance: Review of Evaluation To Address Gas Accumulation Issues in Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... of the comments. A document comparing the version of the ISG that went out for public comment and the final version of the ISG can be found under ADAMS Accession No. ML111170302. ADDRESSES: Publicly... its issued staff guidance in the agency external web page ( http://www.nrc.gov/reading-rm/doc...

  15. Summary report, Flexible VSR`s and VSR channel sleeve development programs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kempf, F.J.

    1963-11-15

    (VSR = vertical safety rod.) This report summarizes results of development programs which have evaluated vertical rod channel sleeving materials and provided flexible vertical rods, acceptable for both interim use before rod channel sleeving, and for subsequent use in sleeved channels. B{sub 4}C is the rod material; graphite and Al oxide are among the sleeve materials.

  16. NREL Provides First-of-its-Kind Guidance Promoting Safety Standards for

    Science.gov Websites

    Promoting Safety Standards for Natural Gas Vehicle Maintenance Facilities NREL Provides First-of-its-Kind Guidance Promoting Safety Standards for Natural Gas Vehicle Maintenance Facilities December 1, 2017 The U.S vehicle maintenance facilities with a new handbook and webinar that outline safety factors and standards

  17. 77 FR 43583 - DOE Response to Recommendation 2012-1 of the Defense Nuclear Facilities Safety Board, Savannah...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... DEPARTMENT OF ENERGY DOE Response to Recommendation 2012-1 of the Defense Nuclear Facilities Safety Board, Savannah River Site Building 235-F Safety AGENCY: Department of Energy. ACTION: Notice. SUMMARY: On May 8, 2012, the Defense Nuclear Facilities Safety Board submitted Recommendation 2012-1...

  18. Safety and Effectiveness of Natalizumab: First Report of Interim Results of Post-Marketing Surveillance in Japan.

    PubMed

    Saida, Takahiko; Yokoyama, Kazumasa; Sato, Ryusuke; Makioka, Haruki; Iizuka, Yukihiko; Hase, Masakazu; Ling, Yan; Torii, Shinichi

    2017-12-01

    Natalizumab, a humanized anti-α4 integrin monoclonal antibody, received marketing approval in Japan in 2014 for the treatment of multiple sclerosis (MS). Because the previous large-scale clinical trials of natalizumab were mainly conducted in Europe and North American countries, and data in patients with MS from Japan were limited, we conducted an all-case post-marketing surveillance of natalizumab-treated MS patients from Japan to investigate the safety and effectiveness of natalizumab in a real-world clinical setting in Japan. Here, we report the results of an interim analysis. During the observation period of 2 years, all patients who were treated with natalizumab subsequent to its approval in Japan were followed. The effectiveness of natalizumab was assessed by examining the changes in expanded disability status scale (EDSS) score and annualized relapse rate (ARR) from baseline. Safety was assessed by analyzing the incidence of adverse drug reactions (ADRs). The safety analysis included 106 patients (mean age 39.3 years; women 62.3%) whose data were collected until the data lock point (February 7, 2016). The effectiveness analysis included 75 patients. The majority of patients had relapsing-remitting MS (93/106 patients; 87.7%). The mean length of treatment exposure in the present study was 6.6 months. During the 2-year observation period, no significant change in the EDSS was observed, while the ARR decreased significantly from baseline (72.9% reduction, p = 0.001). ADRs and serious ADRs were observed in 11.3% and 3.8% of patients, respectively; however, no new safety concerns were detected. No patient had progressive multifocal leukoencephalopathy (PML) during the present study period. The safety and effectiveness of natalizumab were confirmed in Japanese patients with MS in clinical practice. Nevertheless, potential risks including PML require continuous, careful observation. Biogen Japan Ltd (Tokyo, Japan).

  19. The interim regulated legal market for NPS ('legal high') products in New Zealand: The impact of new retail restrictions and product licensing.

    PubMed

    Wilkins, Chris

    2014-01-01

    New Zealand has recently established the world's first regulated legal market for new psychoactive products (NPS) (i.e. 'legal highs'). While the new regime is currently in a transitional phase, a range of retail restrictions and an interim licensing regime for NPS products and operators has been introduced. A product safety assessment framework has been developed to determine if a product should receive an interim licence. As a result of the licensing requirements, the number of NPS retail outlets fell from 3000- 4000 largely convenience stores to 156 specialty stores, and the number of legally available NPS products fell from 200 to fewer than 46. Some of the licensed products contain potent cannabinoid compounds. The licensing system provided, for the first time, information on all the products and operators involved in the sector, and this will assist future monitoring. The effectiveness of the new product safety assessment framework will depend on the quality of the data available on adverse cases. This is a challenge as self-reported information from users is often unreliable, and some emergency department cases do not have all the information required to make an accurate assessment. These data limitations indicate the need for retrospective studies of NPS adverse cases and additional test data. While the new legislation initially reduced the number of NPS retailers by prohibiting convenience outlets, new specialized NPS retail outlets may emerge as the new sector expands. Empirical research is required to measure the impact of the reduction in retail outlets and products on NPS availability. Copyright © 2014 John Wiley & Sons, Ltd.

  20. Immunogenicity, efficacy and safety of Nuwiq® (human-cl rhFVIII) in previously untreated patients with severe haemophilia A-Interim results from the NuProtect Study.

    PubMed

    Liesner, R J; Abashidze, M; Aleinikova, O; Altisent, C; Belletrutti, M J; Borel-Derlon, A; Carcao, M; Chambost, H; Chan, A K C; Dubey, L; Ducore, J; Fouzia, N A; Gattens, M; Gruel, Y; Guillet, B; Kavardakova, N; El Khorassani, M; Klukowska, A; Lambert, T; Lohade, S; Sigaud, M; Turea, V; Wu, J K M; Vdovin, V; Pavlova, A; Jansen, M; Belyanskaya, L; Walter, O; Knaub, S; Neufeld, E J

    2018-03-01

    Nuwiq ® (Human-cl rhFVIII) is a fourth generation recombinant FVIII, produced in a human cell line, without chemical modification or protein fusion. No inhibitors developed in studies with Nuwiq ® in 201 previously treated patients with haemophilia A (HA). The immunogenicity, efficacy and safety of Nuwiq ® in previously untreated patients (PUPs) with severe HA are being assessed in the ongoing NuProtect study. The study, conducted across 38 centres worldwide, is evaluating 110 true PUPs of all ages and ethnicities enrolled for study up to 100 exposure days (EDs) or 5 years maximum. The primary objective is to assess the immunogenicity of Nuwiq ® (inhibitor activity ≥0.6 BU) using the Nijmegen-modified Bethesda assay at a central laboratory. Data for 66 PUPs with ≥20 EDs from a preplanned interim analysis were analysed. High-titre (HT) inhibitors developed in 8 of 66 patients after a median of 11.5 EDs (range 6-24). Five patients developed low-titre inhibitors (4 transient). The cumulative incidence (95% confidence interval) was 12.8% (4.5%, 21.2%) for HT inhibitors and 20.8% (10.7%, 31.0%) for all inhibitors. During inhibitor-free periods, median annualized bleeding rates during prophylaxis were 0 for spontaneous bleeds and 2.40 for all bleeds. Efficacy was rated as "excellent" or "good" in treating 91.8% of bleeds. Efficacy of surgical prophylaxis was "excellent" or "good" for 8 (89%) procedures and "moderate" for 1 (11%). No tolerability concerns were evident. These interim data show a cumulative incidence of 12.8% for HT inhibitors and convincing efficacy and tolerability in PUPs treated with Nuwiq ® . © 2017 The Authors. Haemophilia published by John Wiley & Sons Ltd.

  1. Nuclear Warheads: The Reliable Replacement Warhead Program and the Life Extension Program

    DTIC Science & Technology

    2007-07-16

    The Defense Nuclear Facilities Safety Board was created by Congress 1988 “as an independent oversight organization within the Executive Branch charged... nuclear facilities .” U.S. Defense Nuclear Facilities Safety Board. “Who We Are,” at [http://www.dnfsb.gov/about/index.html]. beginning, addressed safety...approach, if successful, would “reduce or eliminate the need for ESD controls.”55 Kent Fortenberry, Technical Director of the Defense Nuclear Facilities Safety

  2. Animal-assisted interventions: A national survey of health and safety policies in hospitals, eldercare facilities, and therapy animal organizations.

    PubMed

    Linder, Deborah E; Siebens, Hannah C; Mueller, Megan K; Gibbs, Debra M; Freeman, Lisa M

    2017-08-01

    Animal-assisted intervention (AAI) programs are increasing in popularity, but it is unknown to what extent therapy animal organizations that provide AAI and the hospitals and eldercare facilities they work with implement effective animal health and safety policies to ensure safety of both animals and humans. Our study objective was to survey hospitals, eldercare facilities, and therapy animal organizations on their AAI policies and procedures. A survey of United States hospitals, eldercare facilities, and therapy animal organizations was administered to assess existing health and safety policies related to AAI programs. Forty-five eldercare facilities, 45 hospitals, and 27 therapy animal organizations were surveyed. Health and safety policies varied widely and potentially compromised human and animal safety. For example, 70% of therapy animal organizations potentially put patients at risk by allowing therapy animals eating raw meat diets to visit facilities. In general, hospitals had stricter requirements than eldercare facilities. This information suggests that there are gaps between the policies of facilities and therapy animal organizations compared with recent guidelines for animal visitation in hospitals. Facilities with AAI programs need to review their policies to address recent AAI guidelines to ensure the safety of animals and humans involved. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  3. Integrated Framework for Patient Safety and Energy Efficiency in Healthcare Facilities Retrofit Projects.

    PubMed

    Mohammadpour, Atefeh; Anumba, Chimay J; Messner, John I

    2016-07-01

    There is a growing focus on enhancing energy efficiency in healthcare facilities, many of which are decades old. Since replacement of all aging healthcare facilities is not economically feasible, the retrofitting of these facilities is an appropriate path, which also provides an opportunity to incorporate energy efficiency measures. In undertaking energy efficiency retrofits, it is vital that the safety of the patients in these facilities is maintained or enhanced. However, the interactions between patient safety and energy efficiency have not been adequately addressed to realize the full benefits of retrofitting healthcare facilities. To address this, an innovative integrated framework, the Patient Safety and Energy Efficiency (PATSiE) framework, was developed to simultaneously enhance patient safety and energy efficiency. The framework includes a step -: by -: step procedure for enhancing both patient safety and energy efficiency. It provides a structured overview of the different stages involved in retrofitting healthcare facilities and improves understanding of the intricacies associated with integrating patient safety improvements with energy efficiency enhancements. Evaluation of the PATSiE framework was conducted through focus groups with the key stakeholders in two case study healthcare facilities. The feedback from these stakeholders was generally positive, as they considered the framework useful and applicable to retrofit projects in the healthcare industry. © The Author(s) 2016.

  4. Proposed Guidance for Preparing and Reviewing Molten Salt Nonpower Reactor Licence Applications (NUREG-1537)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Belles, Randy; Flanagan, George F.; Voth, Marcus

    Development of non-power molten salt reactor (MSR) test facilities is under consideration to support the analyses needed for development of a full-scale MSR. These non-power MSR test facilities will require review by the US Nuclear Regulatory Commission (NRC) staff. This report proposes chapter adaptations for NUREG-1537 in the form of interim staff guidance to address preparation and review of molten salt non-power reactor license applications. The proposed adaptations are based on a previous regulatory gap analysis of select chapters from NUREG-1537 for their applicability to non-power MSRs operating with a homogeneous fuel salt mixture.

  5. Safe design of healthcare facilities

    PubMed Central

    Reiling, J

    2006-01-01

    The physical environment has a significant impact on health and safety; however, hospitals have not been designed with the explicit goal of enhancing patient safety through facility design. In April 2002, St Joseph's Community Hospital of West Bend, a member of SynergyHealth, brought together leaders in healthcare and systems engineering to develop a set of safety‐driven facility design recommendations and principles that would guide the design of a new hospital facility focused on patient safety. By introducing safety‐driven innovations into the facility design process, environmental designers and healthcare leaders will be able to make significant contributions to patient safety. PMID:17142606

  6. 76 FR 17627 - Sunshine Act Meeting Postponed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting Postponed AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of public meeting postponement. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register of March 3, 2011 (76 FR 11764...

  7. 77 FR 14007 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting Notice Federal Register CITATION OF... THE MEETING: The Defense Nuclear Facilities Safety Board (Board) is expanding the matters to be.../ resolution of safety and technical issues across the defense nuclear facilities complex. Since this panel...

  8. Shielding calculation and criticality safety analysis of spent fuel transportation cask in research reactors.

    PubMed

    Mohammadi, A; Hassanzadeh, M; Gharib, M

    2016-02-01

    In this study, shielding calculation and criticality safety analysis were carried out for general material testing reactor (MTR) research reactors interim storage and relevant transportation cask. During these processes, three major terms were considered: source term, shielding, and criticality calculations. The Monte Carlo transport code MCNP5 was used for shielding calculation and criticality safety analysis and ORIGEN2.1 code for source term calculation. According to the results obtained, a cylindrical cask with body, top, and bottom thicknesses of 18, 13, and 13 cm, respectively, was accepted as the dual-purpose cask. Furthermore, it is shown that the total dose rates are below the normal transport criteria that meet the standards specified. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Confinement of Radioactive Materials at Defense Nuclear Facilities

    DTIC Science & Technology

    2004-10-01

    The design of defense nuclear facilities includes systems whose reliable operation is vital to the protection of the public, workers, and the...final safety-class barrier to the release of hazardous materials with potentially serious public consequences. The Defense Nuclear Facilities Safety...the public at certain defense nuclear facilities . This change has resulted in downgrading of the functional safety classification of confinement

  10. Fire safety of ground-based space facilities on the spaceport ;Vostochny;

    NASA Astrophysics Data System (ADS)

    Artamonov, Vladimir S.; Gordienko, Denis M.; Melikhov, Anatoly S.

    2017-06-01

    The facilities of the spaceport ;Vostochny; and the innovative technologies for fire safety to be implemented are considered. The planned approaches and prospects for fire safety ensuring at the facilities of the spaceport ;Vostochny; are presented herein, based on the study of emergency situations having resulted in fire accidents and explosion cases at the facilities supporting space vehicles operation.

  11. Arms Control and Nonproliferation: A Catalog of Treaties and Agreements

    DTIC Science & Technology

    2011-03-23

    produced two agreements— the Interim Agreement ... on Certain Measures with Respect to the Limitation of...Iranian missile threat. The system was to include 10 interceptors based in Poland and a radar in the Czech Republic . Russia’s former President Putin and...that Moscow would not do so if the United States reversed its plan to emplace GMD facilities in Poland and the Czech Republic . Congress resisted the

  12. Quarterly report of RCRA groundwater monitoring data for period January 1, 1993 through March 31, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-07-01

    Hanford Site interim-status groundwater monitoring projects are conducted as either background, indicator parameter evaluation, or groundwater quality assessment monitoring programs as defined in the Resource Conservation and Recovery Act of 1976 (RCRA); and Interim Status Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities, as amended (40 Code of Federal Regulations [CFR] 265). Compliance with the 40 CFR 265 regulations is required by the Washington Administrative Code (WAC) 173-303. This report contains data from Hanford Site groundwater monitoring projects. This quarterly report contains data received between March 8 and May 24, 1993, which are the cutoffmore » dates for this reporting period. This report may contain not only data from the January through March quarter but also data from earlier sampling events that were not previously reported.« less

  13. Superfund Record of Decision (EPA Region 4): USMC Camp Lejeune Military Reservation, NC. (First remedial action), September 1992. Interim report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-09-23

    The 500-acre Camp Lejeune Military Reservation is located 15 miles southeast of Jacksonville, in Onslow County, North Carolina. Within the site lies the Hadnot Point Industrial Area (HPIA), which was constructed in the late 1930's. It is composed of 75 buildings and facilities, which include gas stations, offices, storage yards, maintenance shops, and a dry cleaning plant. Several areas of the HPIA have been investigated for potential contamination attributed to Marine Corps activities and operations that resulted in a generation of potentially hazardous wastes. The ROD addresses an interim remedial action for the shallow aquifer at the HPIA to protectmore » human health from exposure to VOCs and metals. The primary contaminants of concern affecting the shallow ground water aquifer are VOCs, including benzene and TCE; and metals, including arsenic, chromium, and lead.« less

  14. Health Resources Priority and Allocations System (HRPAS). Interim final rule.

    PubMed

    2015-07-17

    This interim final rule establishes standards and procedures by which the U.S. Department of Health and Human Services (HHS) may require that certain contracts or orders that promote the national defense be given priority over other contracts or orders. This rule also sets new standards and procedures by which HHS may allocate materials, services, and facilities to promote the national defense. This rule will implement HHS's administration of priorities and allocations actions, and establish the Health Resources Priorities and Allocation System (HRPAS). The HRPAS will cover health resources pursuant to the authority under Section 101(c) of the Defense Production Act as delegated to HHS by Executive Order 13603. Priorities authorities (and other authorities delegated to the Secretary in E.O. 13603, but not covered by this regulation) may be re-delegated by the Secretary. The Secretary retains the authority for allocations.

  15. 75 FR 27228 - Proposed FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of proposed rulemaking. SUMMARY: Pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations, the Defense Nuclear Facilities Safety Board is...

  16. 77 FR 41258 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to...

  17. 76 FR 28194 - Proposed FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 Proposed FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of proposed rulemaking. SUMMARY: Pursuant to 10 CFR 1703.107(b)(6) of the Board's regulations, the Defense Nuclear Facilities Safety Board is...

  18. 76 FR 43819 - FOIA Fee Schedule Update

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD 10 CFR Part 1703 FOIA Fee Schedule Update AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Establishment of FOIA Fee Schedule. SUMMARY: The Defense Nuclear Facilities Safety Board is publishing its Freedom of Information Act (FOIA) Fee Schedule Update pursuant to...

  19. 78 FR 20625 - Extension of Hearing Record Closure Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Extension of Hearing Record Closure Date AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Extension of hearing record closure date. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register on January 22, 2013...

  20. 77 FR 65871 - Extension of Hearing Record Closure Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Extension of Hearing Record Closure Date AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Extension of hearing record closure date. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register on August 15, 2012...

  1. 78 FR 1206 - Second Extension of Hearing Record Closure Date

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Second Extension of Hearing Record Closure Date AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Second extension of hearing record closure date. SUMMARY: The Defense Nuclear Facilities Safety Board (Board) published a document in the Federal Register on...

  2. Assessing Irregular Warfare: A Framework for Intelligence Analysis

    DTIC Science & Technology

    2008-01-01

    AND HEALTH CARE INTERNATIONAL AFFAIRS NATIONAL SECURITY POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY SUBSTANCE ABUSE TERRORISM AND...Interim FSTC Foreign Science and Technology Center GMI general military intelligence IED improvised explosive device INSCOM Intelligence and Security...ground forces intelligence in the Department of Defense (DoD).1 NGIC was created in March 1995, when the U.S. Army Foreign Science and Technology

  3. 20 CFR 410.490 - Interim adjudicatory rules for certain part B claims filed by a miner before July 1, 1973, or by...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to... the Black Lung Act of 1972, the Congress noted that adjudication of the large backlog of claims... pneumoconiosis, or to have been totally disabled due to pneumoconiosis at the time of his death, or his death...

  4. 20 CFR 410.490 - Interim adjudicatory rules for certain part B claims filed by a miner before July 1, 1973, or by...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to... the Black Lung Act of 1972, the Congress noted that adjudication of the large backlog of claims... pneumoconiosis, or to have been totally disabled due to pneumoconiosis at the time of his death, or his death...

  5. Alternatives Generation and Analysis for Heat Removal from High Level Waste Tanks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    WILLIS, W.L.

    This document addresses the preferred combination of design and operational configurations to provide heat removal from high-level waste tanks during Phase 1 waste feed delivery to prevent the waste temperature from exceeding tank safety requirement limits. An interim decision for the preferred method to remove the heat from the high-level waste tanks during waste feed delivery operations is presented herein.

  6. Lanthanum carbonate: safety data after 10 years.

    PubMed

    Hutchison, Alastair J; Wilson, Rosamund J; Garafola, Svetlana; Copley, John Brian

    2016-12-01

    Despite 10 years of post-marketing safety monitoring of the phosphate binder lanthanum carbonate, concerns about aluminium-like accumulation and toxicity persist. Here, we present a concise overview of the safety profile of lanthanum carbonate and interim results from a 5-year observational database study (SPD405-404; ClinicalTrials.gov identifier: NCT00567723). The pharmacokinetic paradigms of lanthanum and aluminium are different in that lanthanum is minimally absorbed and eliminated via the hepatobiliary pathway, whereas aluminium shows appreciable absorption and is eliminated by the kidneys. Randomised prospective studies of paired bone biopsies revealed no evidence of accumulation or toxicity in patients treated with lanthanum carbonate. Patients treated with lanthanum carbonate for up to 6 years showed no clinically relevant changes in liver enzyme or bilirubin levels. Lanthanum does not cross the intact blood-brain barrier. The most common adverse effects are mild/moderate nausea, diarrhoea and flatulence. An interim Kaplan-Meier analysis of SPD405-404 data from the United States Renal Data System revealed that the median 5-year survival was 51.6 months (95% CI: 49.1, 54.2) in patients who received lanthanum carbonate (test group), 48.9 months (95% CI: 47.3, 50.5) in patients treated with other phosphate binders (concomitant therapy control group) and 40.3 months (95% CI: 38.9, 41.5) in patients before the availability of lanthanum carbonate (historical control group). Bone fracture rates were 5.9%, 6.7% and 6.4%, respectively. After more than 850 000 person-years of worldwide patient exposure, there is no evidence that lanthanum carbonate is associated with adverse safety outcomes in patients with end-stage renal disease. © 2016 Shire Development LLC. Nephrology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Nephrology.

  7. Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension.

    PubMed

    Santos, Raul D; Duell, P Barton; East, Cara; Guyton, John R; Moriarty, Patrick M; Chin, Wai; Mittleman, Robert S

    2015-03-01

    To evaluate the efficacy and safety of extended dosing with mipomersen in patients with familial hypercholesterolaemia (HC) taking maximally tolerated lipid-lowering therapy. A planned interim analysis of an ongoing, open-label extension trial in patients (n = 141) with familial HC receiving a subcutaneous injection of 200 mg mipomersen weekly plus maximally tolerated lipid-lowering therapy for up to 104 weeks. The mean changes in low-density lipoprotein cholesterol (LDL-C) from baseline to weeks 26 (n = 130), 52 (n = 111), 76 (n = 66), and 104 (n = 53) were -28, -27, -27, and -28%; and in apolipoprotein B -29, -28, -30, and -31%, respectively. Reductions in total cholesterol, non-high-density lipoprotein-cholesterol, and lipoprotein(a) were comparable with decreases in LDL-C and apolipoprotein B levels. Mean high-density lipoprotein cholesterol increased from baseline by 7 and 6% at weeks 26 and 52, respectively. The long-term safety profile of mipomersen was similar to that reported in the associated randomized placebo-controlled Phase 3 trials. Adverse events included injection site reactions and flu-like symptoms. There was an incremental increase in the median liver fat during the initial 6-12 months that appeared to diminish with continued mipomersen exposure beyond 1 year and returned towards baseline 24 weeks after last drug dose suggestive of adaptation. The median alanine aminotransferase level showed a similar trend over time. Long-term treatment with mipomersen for up to 104 weeks provided sustained reductions in all atherosclerotic lipoproteins measured and a safety profile consistent with prior controlled trials in these high-risk patient populations. CLINICALTRIALS.GOV: NCT00694109. © The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology.

  8. Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension

    PubMed Central

    Santos, Raul D.; Duell, P. Barton; East, Cara; Guyton, John R.; Moriarty, Patrick M.; Chin, Wai; Mittleman, Robert S.

    2015-01-01

    Aims To evaluate the efficacy and safety of extended dosing with mipomersen in patients with familial hypercholesterolaemia (HC) taking maximally tolerated lipid-lowering therapy. Methods and results A planned interim analysis of an ongoing, open-label extension trial in patients (n = 141) with familial HC receiving a subcutaneous injection of 200 mg mipomersen weekly plus maximally tolerated lipid-lowering therapy for up to 104 weeks. The mean changes in low-density lipoprotein cholesterol (LDL-C) from baseline to weeks 26 (n = 130), 52 (n = 111), 76 (n = 66), and 104 (n = 53) were −28, −27, −27, and −28%; and in apolipoprotein B −29, −28, −30, and −31%, respectively. Reductions in total cholesterol, non-high-density lipoprotein-cholesterol, and lipoprotein(a) were comparable with decreases in LDL-C and apolipoprotein B levels. Mean high-density lipoprotein cholesterol increased from baseline by 7 and 6% at weeks 26 and 52, respectively. The long-term safety profile of mipomersen was similar to that reported in the associated randomized placebo-controlled Phase 3 trials. Adverse events included injection site reactions and flu-like symptoms. There was an incremental increase in the median liver fat during the initial 6–12 months that appeared to diminish with continued mipomersen exposure beyond 1 year and returned towards baseline 24 weeks after last drug dose suggestive of adaptation. The median alanine aminotransferase level showed a similar trend over time. Conclusion Long-term treatment with mipomersen for up to 104 weeks provided sustained reductions in all atherosclerotic lipoproteins measured and a safety profile consistent with prior controlled trials in these high-risk patient populations. Clinicaltrials.gov NCT00694109. PMID:24366918

  9. 78 FR 65978 - Draft Revised Strategic Plan for FY 2014-2018

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Draft Revised Strategic Plan for FY 2014-2018 AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice. SUMMARY: In accordance with Office of Management and Budget Circular No. A-11, the Defense Nuclear Facilities Safety Board (DNFSB) is soliciting...

  10. 75 FR 4794 - Draft Revised Strategic Plan for FY 2010-2015

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Draft Revised Strategic Plan for FY 2010-2015 AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice. SUMMARY: In accordance with OMB Circular No. A-11, the Defense Nuclear Facilities Safety Board is soliciting comments from all interested and potentially...

  11. Annual Report To Congress. Department of Energy Activities Relating to the Defense Nuclear Facilities Safety Board, Calendar Year 2003

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    2004-02-28

    The Department of Energy (Department) submits an Annual Report to Congress each year detailing the Department’s activities relating to the Defense Nuclear Facilities Safety Board (Board), which provides advice and recommendations to the Secretary of Energy (Secretary) regarding public health and safety issues at the Department’s defense nuclear facilities. In 2003, the Department continued ongoing activities to resolve issues identified by the Board in formal recommendations and correspondence, staff issue reports pertaining to Department facilities, and public meetings and briefings. Additionally, the Department is implementing several key safety initiatives to address and prevent safety issues: safety culture and review ofmore » the Columbia accident investigation; risk reduction through stabilization of excess nuclear materials; the Facility Representative Program; independent oversight and performance assurance; the Federal Technical Capability Program (FTCP); executive safety initiatives; and quality assurance activities. The following summarizes the key activities addressed in this Annual Report.« less

  12. 75 FR 66683 - Defense Federal Acquisition Regulation Supplement; Safety of Facilities, Infrastructure, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... operation of facilities, infrastructure, and equipment for use by DoD military or civilian should be...-7004, Safety of Facilities, Infrastructure, and Equipment for Military Operations. DFARS 246.270-1... operation of facilities. This includes contracts for facilities, infrastructure, and equipment configured...

  13. Waste Determination Equivalency - 12172

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Freeman, Rebecca D.

    2012-07-01

    The Savannah River Site (SRS) is a Department of Energy (DOE) facility encompassing approximately 800 square kilometers near Aiken, South Carolina which began operations in the 1950's with the mission to produce nuclear materials. The SRS contains fifty-one tanks (2 stabilized, 49 yet to be closed) distributed between two liquid radioactive waste storage facilities at SRS containing carbon steel underground tanks with storage capacities ranging from 2,800,000 to 4,900,000 liters. Treatment of the liquid waste from these tanks is essential both to closing older tanks and to maintaining space needed to treat the waste that is eventually vitrified or disposedmore » of onsite. Section 3116 of the Ronald W. Reagan National Defense Authorization Act of Fiscal Year 2005 (NDAA) provides the Secretary of Energy, in consultation with the Nuclear Regulatory Commission (NRC), a methodology to determine that certain waste resulting from prior reprocessing of spent nuclear fuel are not high-level radioactive waste if it can be demonstrated that the waste meets the criteria set forth in Section 3116(a) of the NDAA. The Secretary of Energy, in consultation with the NRC, signed a determination in January 2006, pursuant to Section 3116(a) of the NDAA, for salt waste disposal at the SRS Saltstone Disposal Facility. This determination is based, in part, on the Basis for Section 3116 Determination for Salt Waste Disposal at the Savannah River Site and supporting references, a document that describes the planned methods of liquid waste treatment and the resulting waste streams. The document provides descriptions of the proposed methods for processing salt waste, dividing them into 'Interim Salt Processing' and later processing through the Salt Waste Processing Facility (SWPF). Interim Salt Processing is separated into Deliquification, Dissolution, and Adjustment (DDA) and Actinide Removal Process/Caustic Side Solvent Extraction Unit (ARP/MCU). The Waste Determination was signed by the Secretary of Energy in January of 2006 based on proposed processing techniques with the expectation that it could be revised as new processing capabilities became viable. Once signed, however, it became evident that any changes would require lengthy review and another determination signed by the Secretary of Energy. With the maturation of additional salt removal technologies and the extension of the SWPF start-up date, it becomes necessary to define 'equivalency' to the processes laid out in the original determination. For the purposes of SRS, any waste not processed through Interim Salt Processing must be processed through SWPF or an equivalent process, and therefore a clear statement of the requirements for a process to be equivalent to SWPF becomes necessary. (authors)« less

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cummins, G.D.

    This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste is subject to the TSCA regulations of 40 CFR 761. Interim approval is requested for a period not to exceed 5 years from the date of approval. This request covers only the disposal of small 10 quantities of solid PCB waste contained in decommissioned, defueled submarine reactor compartments (SRC). In addition, the request applies only to disposal 12 of thismore » waste in Trench 94 of the 218-E-12B Burial Ground (Trench 94) in the 13 200 East Area of the US Department of Energy`s (DOE) Hanford Facility. Disposal of this waste will be conducted in accordance with the Compliance 15 Agreement (Appendix H) between the DOE Richland Operations Office (DOE-RL) and 16 the US Environmental Protection Agency (EPA), Region 10. During the 5-year interim approval period, the DOE-RL will submit an application seeking final 18 approval for operation of Trench 94 as a chemical waste landfill, including 19 any necessary waivers, and also will seek a final dangerous waste permit from 20 the Washington State Department of Ecology (Ecology) for disposal of lead 21 shielding contained in the SRCS.« less

  15. Medicaid program; home and community-based services waivers for individuals age 65 or older--HCFA. Interim final rule with comment period.

    PubMed

    1992-06-30

    This interim final rule amends current Medicaid regulations to permit States to offer, under a Secretarial waiver, a wide array of home and community-based services to individuals age 65 or older who are determined, but for the provision of these services, to be likely to require the level of care furnished in a skilled nursing facility (SNF) or intermediate care facility (ICF) (nursing facility (NF) effective October 1, 1990). The rule allows Federal payment for these and other long term care services, up to an amount specified in section 1915(d)(5)(B) of the Social Security Act, subject to HCFA's approval of the States' requests for waivers and certain assurances made by the States. Once granted, waivers are in effect for 3 years, unless terminated by the State with notice to the Secretary, and are renewable for periods of 5 years. Periodic evaluation, assessment, and review of the care furnished under the waivers is required. This rule implements section 4102 of the Omnibus Budget Reconciliation Act of 1987, as modified by section 411(k) of the Medicare Catastrophic Coverage Act of 1988, section 8432 of the Technical and Miscellaneous Revenue Act of 1988, and section 4741(b) of the Omnibus Budget Reconciliation Act of 1990. This rule is being issued in final and, for the most part, without a delay in the effective date for the reasons explained in section IV, "Waiver of Proposed Rulemaking and Delay in the Effective Date."

  16. 48 CFR 252.246-7004 - Safety of Facilities, Infrastructure, and Equipment for Military Operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: SAFETY OF FACILITIES, INFRASTRUCTURE, AND EQUIPMENT FOR MILITARY OPERATIONS (OCT 2010) (a) Definition... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Safety of Facilities, Infrastructure, and Equipment for Military Operations. 252.246-7004 Section 252.246-7004 Federal Acquisition...

  17. 48 CFR 246.270 - Safety of facilities, infrastructure, and equipment for military operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ASSURANCE Contract Quality Requirements 246.270 Safety of facilities, infrastructure, and equipment for... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Safety of facilities, infrastructure, and equipment for military operations. 246.270 Section 246.270 Federal Acquisition Regulations...

  18. Safety Information, Transportation & Public Facilities, State of Alaska

    Science.gov Websites

    Department of Transportation & Public Facilities/ Safety Information Search DOT&PF State of Alaska DOT&PF> Safety Information DOT&PF Safety Information link to 511 511.alaska.gov - Traveler Information link to AHSO Alaska Highway Safety Office link to HSIP Highway Safety Improvement Program link to

  19. Safety analysis, 200 Area, Savannah River Plant: Separations area operations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Perkins, W.C.; Lee, R.; Allen, P.M.

    1991-07-01

    The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutoniummore » Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.« less

  20. Background rates of adverse pregnancy outcomes for assessing the safety of maternal vaccine trials in sub-Saharan Africa.

    PubMed

    Orenstein, Lauren A V; Orenstein, Evan W; Teguete, Ibrahima; Kodio, Mamoudou; Tapia, Milagritos; Sow, Samba O; Levine, Myron M

    2012-01-01

    Maternal immunization has gained traction as a strategy to diminish maternal and young infant mortality attributable to infectious diseases. Background rates of adverse pregnancy outcomes are crucial to interpret results of clinical trials in Sub-Saharan Africa. We developed a mathematical model that calculates a clinical trial's expected number of neonatal and maternal deaths at an interim safety assessment based on the person-time observed during different risk windows. This model was compared to crude multiplication of the maternal mortality ratio and neonatal mortality rate by the number of live births. Systematic reviews of severe acute maternal morbidity (SAMM), low birth weight (LBW), prematurity, and major congenital malformations (MCM) in Sub-Saharan African countries were also performed. Accounting for the person-time observed during different risk periods yields lower, more conservative estimates of expected maternal and neonatal deaths, particularly at an interim safety evaluation soon after a large number of deliveries. Median incidence of SAMM in 16 reports was 40.7 (IQR: 10.6-73.3) per 1,000 total births, and the most common causes were hemorrhage (34%), dystocia (22%), and severe hypertensive disorders of pregnancy (22%). Proportions of liveborn infants who were LBW (median 13.3%, IQR: 9.9-16.4) or premature (median 15.4%, IQR: 10.6-19.1) were similar across geographic region, study design, and institutional setting. The median incidence of MCM per 1,000 live births was 14.4 (IQR: 5.5-17.6), with the musculoskeletal system comprising 30%. Some clinical trials assessing whether maternal immunization can improve pregnancy and young infant outcomes in the developing world have made ethics-based decisions not to use a pure placebo control. Consequently, reliable background rates of adverse pregnancy outcomes are necessary to distinguish between vaccine benefits and safety concerns. Local studies that quantify population-based background rates of adverse pregnancy outcomes will improve safety assessment of interventions during pregnancy.

  1. Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease.

    PubMed

    Galasko, Douglas; Bell, Joanne; Mancuso, Jessica Y; Kupiec, James W; Sabbagh, Marwan N; van Dyck, Christopher; Thomas, Ronald G; Aisen, Paul S

    2014-04-29

    To examine safety, tolerability, and efficacy of PF-04494700, an inhibitor of the receptor for advanced glycation end products (RAGE), in mild to moderate Alzheimer disease (AD). Double-blind, placebo-controlled trial at 40 academic centers (United States). Subjects with AD and Mini-Mental State Examination score 14-26 were randomized to PF-04494700 60 mg/day × 6 days, then 20 mg daily (high dose); 15 mg/day × 6 days, then 5 mg daily (low dose); or placebo, for 18 months. Clinical and laboratory measures were used to evaluate safety and tolerability. The primary efficacy measure was the Alzheimer's Disease Assessment Scale-cognitive (ADAS-cog). Secondary measures assessed clinical stage, function, behavior, MRI, and CSF biomarkers. A total of 399 subjects were randomized. In a prespecified interim analysis, when 50% of subjects had completed the 6-month visit, the high dose was associated with confusion, falls, and greater ADAS-cog decline and was discontinued. A second prespecified analysis compared low-dose and placebo groups for futility and safety approximately 12 months after all subjects were randomized. This analysis met criteria for futility, and treatment was discontinued. There were no safety concerns in the low-dose group. Analyses including post-futility data showed decreased decline on the ADAS-cog in the low-dose group at month 18. Other clinical and biomarker measures showed no differences between low-dose treatment and placebo. PF-04494700 at 20 mg/d was associated with increased adverse events and cognitive decline. At 5 mg/d, PF-04494700 had a good safety profile. A potential benefit for this low dose on the ADAS-cog is not conclusive, because of high dropout and discontinuation rates subsequent to the interim analyses. This study provides Class I evidence that in patients with AD high-dose PF-04494700 increased cognitive decline at 6 months and Class IV evidence that low-dose PF-04494700 slowed cognitive decline at 18 months.

  2. Overview of Energy Systems' safety analysis report programs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-03-01

    The primary purpose of an Safety Analysis Report (SAR) is to provide a basis for judging the adequacy of a facility's safety. The SAR documents the safety analyses that systematically identify the hazards posed by the facility, analyze the consequences and risk of potential accidents, and describe hazard control measures that protect the health and safety of the public and employees. In addition, some SARs document, as Technical Safety Requirements (TSRs, which include Technical Specifications and Operational Safety Requirements), technical and administrative requirements that ensure the facility is operated within prescribed safety limits. SARs also provide conveniently summarized information thatmore » may be used to support procedure development, training, inspections, and other activities necessary to facility operation. This Overview of Energy Systems Safety Analysis Report Programs'' Provides an introduction to the programs and processes used in the development and maintenance of the SARs. It also summarizes some of the uses of the SARs within Energy Systems and DOE.« less

  3. Brown continues crusade against earmarking

    NASA Astrophysics Data System (ADS)

    Leath, Audrey T.

    House Science Committee Chairman George Brown (D-Calif.), a crusader against earmarking of academic research and facilities, continues his efforts to raise the subject's visibility with a new report that was released on August 9."Academic Earmarks: An Interim Report by the Chairman of the Committee on Science, Space, and Technology" includes preliminary results of a survey of about fifty institutions receiving recent earmarks and offers a trio of recommendations to help stem the flood of unauthorized projects.

  4. Medicare and Medicaid Programs; Fire Safety Requirements for Certain Health Care Facilities. Final rule.

    PubMed

    2016-05-04

    This final rule will amend the fire safety standards for Medicare and Medicaid participating hospitals, critical access hospitals (CAHs), long-term care facilities, intermediate care facilities for individuals with intellectual disabilities (ICF-IID), ambulatory surgery centers (ASCs), hospices which provide inpatient services, religious non-medical health care institutions (RNHCIs), and programs of all-inclusive care for the elderly (PACE) facilities. Further, this final rule will adopt the 2012 edition of the Life Safety Code (LSC) and eliminate references in our regulations to all earlier editions of the Life Safety Code. It will also adopt the 2012 edition of the Health Care Facilities Code, with some exceptions.

  5. 33 CFR 147.815 - ExxonMobil Hoover Floating OCS Facility safety zone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false ExxonMobil Hoover Floating OCS... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.815 ExxonMobil Hoover Floating OCS Facility safety zone. (a) Description. The ExxonMobil Hoover Floating OCS Facility, Alaminos...

  6. 33 CFR 147.815 - ExxonMobil Hoover Floating OCS Facility safety zone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false ExxonMobil Hoover Floating OCS... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.815 ExxonMobil Hoover Floating OCS Facility safety zone. (a) Description. The ExxonMobil Hoover Floating OCS Facility, Alaminos...

  7. 33 CFR 147.815 - ExxonMobil Hoover Floating OCS Facility safety zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false ExxonMobil Hoover Floating OCS... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.815 ExxonMobil Hoover Floating OCS Facility safety zone. (a) Description. The ExxonMobil Hoover Floating OCS Facility, Alaminos...

  8. 33 CFR 147.815 - ExxonMobil Hoover Floating OCS Facility safety zone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false ExxonMobil Hoover Floating OCS... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES SAFETY ZONES § 147.815 ExxonMobil Hoover Floating OCS Facility safety zone. (a) Description. The ExxonMobil Hoover Floating OCS Facility, Alaminos...

  9. 76 FR 20588 - FDA Food Safety Modernization Act: Focus on Preventive Controls for Facilities; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    .... FDA-2011-N-0251] FDA Food Safety Modernization Act: Focus on Preventive Controls for Facilities... comment. SUMMARY: The Food and Drug Administration (FDA) is announcing a public meeting entitled ``FDA... controls for facilities provisions of the recently enacted FDA Food Safety Modernization Act (FSMA). FDA is...

  10. Case study, comparison of trial burn results from similar sulfuric acid regeneration plants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Milaszewski, M.; Johns, T.; Dickerson, W.F.

    The primary business of Rhodia Eco Services (Rhodia) is the regeneration of sulfuric acid. Sulfuric acid regeneration requires thermal decomposition of acid to sulfur dioxide, and remaking the acid through chemical reaction. The sulfuric acid regeneration furnace is the ideal place to process pumpable wastes for energy recovery and for thermal destruction. Rhodia is regulated by the Boiler and Industrial Furnace (BIF) regulations (40 CFR 266, Subpart H). The Hammond, Indiana plant is an interim status BIF facility and the Houston, Texas facility is renewing its RCRA incineration permit as a BIF facility. Both plants have conducted BIF Trial Burnsmore » with very similar results. The performance levels demonstrated were at levels better than RCRA/BIF standards for destruction and removal efficiency, metal, HCl/Cl, particulate, dioxin/furan, and organic emissions.« less

  11. A historical application of social amplification of risk model: Economic impacts of risk events at nuclear weapons facilities?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Metz, W.C.

    1996-12-31

    Public perceptions of risk have proven to be a critical barrier to the federal government`s extensive, decade-long, technical and scientific effort to site facilities for the interim storage and permanent disposal of high-level radioactive waste (HLW). The negative imagery, fear, and anxiety that are linked to ``nuclear`` and ``radioactive`` technologies, activities, and facilities by the public originate from the personal realities and experiences of individuals and the information they receive. These perceptions continue to be a perplexing problem for those responsible for making decisions about federal nuclear waste management policies and programs. The problem of understanding and addressing public perceptionsmore » is made even more difficult because there are decidedly different opinions about HLW held by the public and nuclear industry and radiation health experts.« less

  12. History of 232-F, tritium extraction processing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blackburn, G.W.

    1994-08-01

    In 1950 the Atomic Energy Commission authorized the Savannah River Project principally for the production of tritium and plutonium-239 for use in thermonuclear weapons. 232-F was built as an interim facility in 1953--1954, at a cost of $3.9M. Tritium extraction operations began in October, 1955, after the reactor and separations startups. In July, 1957 a larger tritium facility began operation in 232-H. In 1958 the capacity of 232-H was doubled. Also, in 1957 a new task was assigned to Savannah River, the loading of tritium into reservoirs that would be actual components of thermonuclear weapons. This report describes the historymore » of 232-F, the process for tritium extraction, and the lessons learned over the years that were eventually incorporated into the new Replacement Tritium Facility.« less

  13. Risk management. National Aeronautics and Space Administration (NASA). Interim rule adopted as final with changes.

    PubMed

    2000-11-22

    This is a final rule amending the NASA FAR Supplement (NFS) to emphasize considerations of risk management, including safety, security (including information technology security), health, export control, and damage to the environment, within the acquisition process. This final rule addresses risk management within the context of acquisition planning, selecting sources, choosing contract type, structuring award fee incentives, administering contracts, and conducting contractor surveillance.

  14. Panasonic Small Cell Testing for AHPS

    NASA Technical Reports Server (NTRS)

    Pearson, C.; Blackmore, P.; Lain, M.; Walpole, A.; Darcy, Eric

    2006-01-01

    AEA selection and successful Interim Design Review for AHPS proves maturity of small cell approach for very large batteries. Cells show excellent opportunity for battery mass reduction for AHPS and other low cycle applications. Lack of cycle and extended calendar life make EOL battery performance difficult (AHPS 8 year mission). Preliminary design, AEA retained SONY 18650HC cell as baseline: a) Well characterized performance; b) Wealth of safety test data.

  15. 75 FR 43495 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities..., structures, and components, and (5) safety-related design aspects of new facilities or modifications of existing facilities needed to deliver high-level waste feed. The Board will be prepared to accept any other...

  16. Functional design criteria for interim stabilization safety class 1 trip circuit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larson, R.E., Westinghouse Hanford

    1996-06-10

    This Functional Design Criteria document outlines the basic requirements for the Safety Class 1 Trip Circuit. The objective of the Safety Class 1 Trip Circuit is to isolate the power circuitry to the Class 1 Division 2, Group B or lesser grade electrically fed loads located in the pump pit. The electrically fed load circuits need to have power isolated to them upon receipt of the following conditions, loss of flammable gases being released (above a predetermined threshold), and seismic(greater than 0.12g acceleration) activity. The two circuits requiring power isolation are the pump and heat trace power circuits. The Safetymore » Class 1 Trip Circuit will be used to support salt well pumping in SST`s containing potentially flammable gas-bearing / gas-producing radioactive waste.« less

  17. An Overview of INEL Fusion Safety R&D Facilities

    NASA Astrophysics Data System (ADS)

    McCarthy, K. A.; Smolik, G. R.; Anderl, R. A.; Carmack, W. J.; Longhurst, G. R.

    1997-06-01

    The Fusion Safety Program at the Idaho National Engineering Laboratory has the lead for fusion safety work in the United States. Over the years, we have developed several experimental facilities to provide data for fusion reactor safety analyses. We now have four major experimental facilities that provide data for use in safety assessments. The Steam-Reactivity Measurement System measures hydrogen generation rates and tritium mobilization rates in high-temperature (up to 1200°C) fusion relevant materials exposed to steam. The Volatilization of Activation Product Oxides Reactor Facility provides information on mobilization and transport and chemical reactivity of fusion relevant materials at high temperature (up to 1200°C) in an oxidizing environment (air or steam). The Fusion Aerosol Source Test Facility is a scaled-up version of VAPOR. The ion-implanta-tion/thermal-desorption system is dedicated to research into processes and phenomena associated with the interaction of hydrogen isotopes with fusion materials. In this paper we describe the capabilities of these facilities.

  18. 33 CFR 165.1406 - Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii. 165.1406 Section 165.1406 Navigation and... Areas Fourteenth Coast Guard District § 165.1406 Safety Zone: Pacific Missile Range Facility (PMRF...

  19. 33 CFR 165.1406 - Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii. 165.1406 Section 165.1406 Navigation and... Areas Fourteenth Coast Guard District § 165.1406 Safety Zone: Pacific Missile Range Facility (PMRF...

  20. 33 CFR 165.1406 - Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii. 165.1406 Section 165.1406 Navigation and... Areas Fourteenth Coast Guard District § 165.1406 Safety Zone: Pacific Missile Range Facility (PMRF...

  1. 33 CFR 165.1406 - Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii. 165.1406 Section 165.1406 Navigation and... Areas Fourteenth Coast Guard District § 165.1406 Safety Zone: Pacific Missile Range Facility (PMRF...

  2. 33 CFR 165.1406 - Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: Pacific Missile Range Facility (PMRF), Barking Sands, Island of Kauai, Hawaii. 165.1406 Section 165.1406 Navigation and... Areas Fourteenth Coast Guard District § 165.1406 Safety Zone: Pacific Missile Range Facility (PMRF...

  3. 33 CFR 147.815 - ExxonMobil Hoover Floating OCS Facility safety zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false ExxonMobil Hoover Floating OCS... Floating OCS Facility safety zone. (a) Description. The ExxonMobil Hoover Floating OCS Facility, Alaminos... (1640.4 feet) from each point on the structure's outer edge is a safety zone. (b) Regulation. No vessel...

  4. Nuclear Warheads: The Reliable Replacement Warhead program and the Life Extension Program

    DTIC Science & Technology

    2007-12-03

    eliminate the need for ESD controls.”67 CRS-22 68 The Defense Nuclear Facilities Safety Board was created by Congress 1988 “as an independent oversight...public health and safety’ at DOE’s defense nuclear facilities .” U.S. Defense Nuclear Facilities Safety Board. “Who We Are,” at [http://www.dnfsb.gov...about/index.html]. 69 Personal communication, Kent Fortenberry, Technical Director, Defense Nuclear Facilities Safety Board, September 14, 2006. 70

  5. Nuclear Warheads: The Reliable Replacement Warhead Program and the Life Extension Program

    DTIC Science & Technology

    2007-04-04

    Information provided by Pantex Plant, Sept. 19, 2006. 50 The Defense Nuclear Facilities Safety Board was created by Congress 1988 “as an independent...protection of public health and safety’ at DOE’s defense nuclear facilities .” U.S. Defense Nuclear Facilities Safety Board. “Who We Are,” at [http...www.dnfsb.gov/about/index.html]. 51 Personal communication, Kent Fortenberry, Technical Director, Defense Nuclear Facilities Safety Board, Sept. 14, 2006

  6. Medicare and Medicaid programs; fire safety requirements for certain health care facilities. Final rule.

    PubMed

    2003-01-10

    This final rule amends the fire safety standards for hospitals, long-term care facilities, intermediate care facilities for the mentally retarded, ambulatory surgery centers, hospices that provide inpatient services, religious nonmedical health care institutions, critical access hospitals, and Programs of All-Inclusive Care for the Elderly facilities. Further, this final rule adopts the 2000 edition of the Life Safety Code and eliminates references in our regulations to all earlier editions.

  7. Recent Upgrades at the Safety and Tritium Applied Research Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cadwallader, Lee Charles; Merrill, Brad Johnson; Stewart, Dean Andrew

    This paper gives a brief overview of the Safety and Tritium Applied Research (STAR) facility operated by the Fusion Safety Program (FSP) at the Idaho National Laboratory (INL). FSP researchers use the STAR facility to carry out experiments in tritium permeation and retention in various fusion materials, including wall armor tile materials. FSP researchers also perform other experimentation as well to support safety assessment in fusion development. This lab, in its present two-building configuration, has been in operation for over ten years. The main experiments at STAR are briefly described. This paper discusses recent work to enhance personnel safety atmore » the facility. The STAR facility is a Department of Energy less than hazard category 3 facility; the personnel safety approach calls for ventilation and tritium monitoring for radiation protection. The tritium areas of STAR have about 4 to 12 air changes per hour, with air flow being once through and then routed to the facility vent stack. Additional radiation monitoring has been installed to read the laboratory room air where experiments with tritium are conducted. These ion chambers and bubblers are used to verify that no significant tritium concentrations are present in the experiment rooms. Standby electrical power has been added to the facility exhaust blower so that proper ventilation will now operate during commercial power outages as well as the real-time tritium air monitors.« less

  8. Health and safety programs for art and theater schools.

    PubMed

    McCann, M

    2001-01-01

    A wide variety of health and safety hazards exist in schools and colleges of art and theater due to a lack of formal health and safety programs and a failure to include health and safety concerns during planning of new facilities and renovation of existing facilities. This chapter discusses the elements of a health and safety program as well as safety-related structural and equipment needs that should be in the plans for any school of art or theater. These elements include curriculum content, ventilation, storage, housekeeping, waste management, fire and explosion prevention, machine and tool safety, electrical safety, noise, heat stress, and life safety and emergency procedures and equipment. Ideally, these elements should be incorporated into the plans for any new facilities, but ongoing programs can also benefit from a review of existing health and safety programs.

  9. Earfold Implantable Clip System for Correction of Prominent Ears: Analysis of Safety in 403 Patients

    PubMed Central

    Sojitra, Nilesh; Glumicic, Sinisa; Vlok, Jacobus A.; O’Toole, Greg; Hannan, S. Alam; Sabbagh, Walid

    2018-01-01

    Background: The Earfold system, a new treatment for the correction of prominent ears, consists of 3 components: the Earfold implant, the Earfold introducer, and the Prefold positioner. Methods: This is an interim report based on an ongoing analysis of safety in a series of patients treated for prominent ears with the Earfold implant between February 2013 and September 2014. Safety was assessed based on adverse event reports and the need for implant revision; follow-up is ongoing. Results: Seven surgeons used 1,200 Earfold implants to treat 403 patients (ages, 7–70 years; 63% male); the time since the initial implant procedure now ranges from 30 to 48 months. To date, 145 patients (36%) have returned for a follow-up visit (mean, 7.7 months [range, 1–34 months]). Adverse events requiring intervention have affected 39 of 403 (9.7%) patients; these include implant revisions (n = 17 [4.2%], most often due to implant visibility), skin erosion over the implant (n = 15 [3.7%]), and infection (n = 7 [1.7%]). Bleeding, recurrence of prominence, hematoma, deformity, or adverse scarring did not occur. Conclusions: This interim analysis has shown that Earfold prominent ear correction system is associated with relatively few adverse events that require intervention; a small number of patients experienced infection, implant extrusion, or implant visibility that required revision. Most adverse events were related to either patient selection or technical errors at implantation. It is expected that with continued use of Earfold by surgeons experienced in otoplasty, the adverse event incidence will decrease. PMID:29464160

  10. 78 FR 49262 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting AGENCY: Defense Nuclear Facilities... given of the Defense Nuclear Facilities Safety Board's (Board) public meeting and hearing described... associated with continued operation of aging defense nuclear [[Page 49263

  11. 76 FR 11339 - Update to NFPA 101, Life Safety Code, for State Home Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... DEPARTMENT OF VETERANS AFFAIRS 38 CFR Part 51 RIN 2900-AN59 Update to NFPA 101, Life Safety Code..., Life Safety Code. The change is designed to assure that State Home facilities meet current industry- wide standards regarding life safety and fire safety. DATES: Effective Date: This final rule is...

  12. 30 CFR 75.1712-2 - Location of surface facilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-2 Location of surface facilities. Bathhouses, change rooms, and sanitary toilet facilities shall be in a location... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Location of surface facilities. 75.1712-2...

  13. 30 CFR 75.1712-2 - Location of surface facilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-2 Location of surface facilities. Bathhouses, change rooms, and sanitary toilet facilities shall be in a location... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Location of surface facilities. 75.1712-2...

  14. 30 CFR 75.1712-2 - Location of surface facilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-2 Location of surface facilities. Bathhouses, change rooms, and sanitary toilet facilities shall be in a location... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Location of surface facilities. 75.1712-2...

  15. 30 CFR 75.1712-2 - Location of surface facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-2 Location of surface facilities. Bathhouses, change rooms, and sanitary toilet facilities shall be in a location... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Location of surface facilities. 75.1712-2...

  16. 30 CFR 75.1712-2 - Location of surface facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Location of surface facilities. 75.1712-2... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-2 Location of surface facilities. Bathhouses, change rooms, and sanitary toilet facilities shall be in a location...

  17. Highway Safety Manual applied in Missouri - freeway/software.

    DOT National Transportation Integrated Search

    2016-06-01

    AASHTOs Highway Safety Manual (HSM) facilitates the quantitative safety analysis of highway facilities. In a 2014 : supplement, freeway facilities were added to the original HSM manual which allows the modeling of highway : interchanges. This repo...

  18. Brown continues crusade against earmarking

    NASA Astrophysics Data System (ADS)

    Leath, Audrey T.

    House Science Committee Chairman George Brown (D-Calif.), a crusader against earmarking of academic research and facilities, continues his efforts to raise the subject's visibility with a new report that was released on August 9.“Academic Earmarks: An Interim Report by the Chairman of the Committee on Science, Space, and Technology” includes preliminary results of a survey of about fifty institutions receiving recent earmarks and offers a trio of recommendations to help stem the flood of unauthorized projects.

  19. Remedial Investigation/Feasibility Study/Interim Response Actions

    DTIC Science & Technology

    1988-03-25

    organosulfur compounds (CC/FP), organophosphorus compounds (CC/FPD), hydrocarbons (CC/FID), volatile aromatic compounds (GC/ PID ), volatile halogenated...ICP metals, mercury and arsenic (AA). Water samples are being analyzed for volatile halogenated organics (GC/CON), volatile aromatic organics (GC/ PID ...Feb Mar Apr May Jun Jul Aug SepSI - I I I I I • .. I I I ----+----- 685 27-90 so ONSITE DISPOSAL FACILITY .i * 686 27-01 Prep FLUE Plan Fz=m8u> 6e7

  20. Safety analysis report for the Waste Storage Facility. Revision 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bengston, S.J.

    1994-05-01

    This safety analysis report outlines the safety concerns associated with the Waste Storage Facility located in the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. The three main objectives of the report are: define and document a safety basis for the Waste Storage Facility activities; demonstrate how the activities will be carried out to adequately protect the workers, public, and environment; and provide a basis for review and acceptance of the identified risk that the managers, operators, and owners will assume.

  1. 75 FR 44817 - Notice of Availability of Uranium Enrichment Fuel Cycle Facility Inspection Reports Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... Uranium Enrichment Fuel Cycle Facility Inspection Reports Regarding Louisiana Energy Services, National... Enrichment Branch, Division of Fuel Cycle Safety and Safeguards, Office of Nuclear Material Safety and... Enrichment Branch, Division of Fuel Cycle Safety and Safeguards, Office of Nuclear Material Safety and...

  2. Public Preferences Related to Radioactive Waste Management in the United States: Methodology and Response Reference Report for the 2016 Energy and Environment Survey.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jenkins-Smith, Hank C.; Silva, Carol L.; Gupta, Kuhika

    This report presents the questions and responses to a nationwide survey taken June 2016 to track preferences of US residents concerning the environment, energy, and radioactive waste management. A focus of the 2016 survey is public perceptions on different options for managing spent nuclear fuel, including on-site storage, interim storage, deep boreholes, general purpose geologic repositories, and geologic repositories for only defense-related waste. Highlights of the survey results include the following: (1) public attention to the 2011 accident and subsequent cleanup at the Fukushima nuclear facility continues to influence the perceived balance of risk and benefit for nuclear energy; (2)more » the incident at the Waste Isolation Pilot Plant in 2014 could influence future public support for nuclear waste management; (3) public knowledge about US nuclear waste management policies has remined higher than seen prior to the Fukushima nuclear accident and submittal of the Yucca Mountain application; (6) support for a mined disposal facility is higher than for deep borehole disposal, building one more interim storage facilities, or continued on-site storage of spent nuclear fuel; (7) support for a repository that comingles commercial and defense related waste is higher than for a repository for only defense related waste; (8) the public’s level of trust accorded to the National Academies, university scientists, and local emergency responders is the highest and the level trust accorded to advocacy organizations, public utilities, and local/national press is the lowest; and (9) the public is willing to serve on citizens panels but, in general, will only modestly engage in issues related to radioactive waste management.« less

  3. Determining initial enrichment, burnup, and cooling time of pressurized-water reactor spent fuel assemblies by analyzing passive gamma spectra measured at the Clab interim-fuel storage facility in Sweden

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Favalli, Andrea; Vo, D.; Grogan, Brandon R.

    The purpose of the Next Generation Safeguards Initiative (NGSI)–Spent Fuel (SF) project is to strengthen the technical toolkit of safeguards inspectors and/or other interested parties. The NGSI–SF team is working to achieve the following technical goals more easily and efficiently than in the past using nondestructive assay measurements of spent fuel assemblies: (1) verify the initial enrichment, burnup, and cooling time of facility declaration; (2) detect the diversion or replacement of pins; (3) estimate the plutonium mass [which is also a function of the variables in (1)]; (4) estimate the decay heat; and (5) determine the reactivity of spent fuelmore » assemblies. Since August 2013, a set of measurement campaigns has been conducted at the Central Interim Storage Facility for Spent Nuclear Fuel (Clab), in collaboration with Swedish Nuclear Fuel and Waste Management Company (SKB). One purpose of the measurement campaigns was to acquire passive gamma spectra with high-purity germanium and lanthanum bromide scintillation detectors from Pressurized Water Reactor and Boiling Water Reactor spent fuel assemblies. The absolute 137Cs count rate and the 154Eu/ 137Cs, 134Cs/ 137Cs, 106Ru/ 137Cs, and 144Ce/ 137Cs isotopic ratios were extracted; these values were used to construct corresponding model functions (which describe each measured quantity’s behavior over various combinations of burnup, cooling time, and initial enrichment) and then were used to determine those same quantities in each measured spent fuel assembly. Furthermore, the results obtained in comparison with the operator declared values, as well as the methodology developed, are discussed in detail in the paper.« less

  4. Determining initial enrichment, burnup, and cooling time of pressurized-water reactor spent fuel assemblies by analyzing passive gamma spectra measured at the Clab interim-fuel storage facility in Sweden

    DOE PAGES

    Favalli, Andrea; Vo, D.; Grogan, Brandon R.; ...

    2016-02-26

    The purpose of the Next Generation Safeguards Initiative (NGSI)–Spent Fuel (SF) project is to strengthen the technical toolkit of safeguards inspectors and/or other interested parties. The NGSI–SF team is working to achieve the following technical goals more easily and efficiently than in the past using nondestructive assay measurements of spent fuel assemblies: (1) verify the initial enrichment, burnup, and cooling time of facility declaration; (2) detect the diversion or replacement of pins; (3) estimate the plutonium mass [which is also a function of the variables in (1)]; (4) estimate the decay heat; and (5) determine the reactivity of spent fuelmore » assemblies. Since August 2013, a set of measurement campaigns has been conducted at the Central Interim Storage Facility for Spent Nuclear Fuel (Clab), in collaboration with Swedish Nuclear Fuel and Waste Management Company (SKB). One purpose of the measurement campaigns was to acquire passive gamma spectra with high-purity germanium and lanthanum bromide scintillation detectors from Pressurized Water Reactor and Boiling Water Reactor spent fuel assemblies. The absolute 137Cs count rate and the 154Eu/ 137Cs, 134Cs/ 137Cs, 106Ru/ 137Cs, and 144Ce/ 137Cs isotopic ratios were extracted; these values were used to construct corresponding model functions (which describe each measured quantity’s behavior over various combinations of burnup, cooling time, and initial enrichment) and then were used to determine those same quantities in each measured spent fuel assembly. Furthermore, the results obtained in comparison with the operator declared values, as well as the methodology developed, are discussed in detail in the paper.« less

  5. Preliminary hazards analysis -- vitrification process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coordes, D.; Ruggieri, M.; Russell, J.

    1994-06-01

    This paper presents a Preliminary Hazards Analysis (PHA) for mixed waste vitrification by joule heating. The purpose of performing a PHA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PHA is then followed by a Preliminary Safety Analysis Report (PSAR) performed during Title 1 and 2 design. The PSAR then leads to performance of the Final Safety Analysis Report performed during the facility`s constructionmore » and testing. It should be completed before routine operation of the facility commences. This PHA addresses the first four chapters of the safety analysis process, in accordance with the requirements of DOE Safety Guidelines in SG 830.110. The hazards associated with vitrification processes are evaluated using standard safety analysis methods which include: identification of credible potential hazardous energy sources; identification of preventative features of the facility or system; identification of mitigative features; and analyses of credible hazards. Maximal facility inventories of radioactive and hazardous materials are postulated to evaluate worst case accident consequences. These inventories were based on DOE-STD-1027-92 guidance and the surrogate waste streams defined by Mayberry, et al. Radiological assessments indicate that a facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous materials assessment indicates that a Mixed Waste Vitrification facility will be a Low Hazard facility having minimal impacts to offsite personnel and the environment.« less

  6. 30 CFR 71.400 - Bathing facilities; change rooms; sanitary flush toilet facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... flush toilet facilities. 71.400 Section 71.400 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY HEALTH STANDARDS-SURFACE COAL MINES AND SURFACE... installations and at the surface worksites of such mine. (Note: Sanitary facilities at surface work areas of...

  7. Improved survival with vemurafenib in melanoma with BRAF V600E mutation.

    PubMed

    Chapman, Paul B; Hauschild, Axel; Robert, Caroline; Haanen, John B; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Garbe, Claus; Testori, Alessandro; Maio, Michele; Hogg, David; Lorigan, Paul; Lebbe, Celeste; Jouary, Thomas; Schadendorf, Dirk; Ribas, Antoni; O'Day, Steven J; Sosman, Jeffrey A; Kirkwood, John M; Eggermont, Alexander M M; Dreno, Brigitte; Nolop, Keith; Li, Jiang; Nelson, Betty; Hou, Jeannie; Lee, Richard J; Flaherty, Keith T; McArthur, Grant A

    2011-06-30

    Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation. We conducted a phase 3 randomized clinical trial comparing vemurafenib with dacarbazine in 675 patients with previously untreated, metastatic melanoma with the BRAF V600E mutation. Patients were randomly assigned to receive either vemurafenib (960 mg orally twice daily) or dacarbazine (1000 mg per square meter of body-surface area intravenously every 3 weeks). Coprimary end points were rates of overall and progression-free survival. Secondary end points included the response rate, response duration, and safety. A final analysis was planned after 196 deaths and an interim analysis after 98 deaths. At 6 months, overall survival was 84% (95% confidence interval [CI], 78 to 89) in the vemurafenib group and 64% (95% CI, 56 to 73) in the dacarbazine group. In the interim analysis for overall survival and final analysis for progression-free survival, vemurafenib was associated with a relative reduction of 63% in the risk of death and of 74% in the risk of either death or disease progression, as compared with dacarbazine (P<0.001 for both comparisons). After review of the interim analysis by an independent data and safety monitoring board, crossover from dacarbazine to vemurafenib was recommended. Response rates were 48% for vemurafenib and 5% for dacarbazine. Common adverse events associated with vemurafenib were arthralgia, rash, fatigue, alopecia, keratoacanthoma or squamous-cell carcinoma, photosensitivity, nausea, and diarrhea; 38% of patients required dose modification because of toxic effects. Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation. (Funded by Hoffmann-La Roche; BRIM-3 ClinicalTrials.gov number, NCT01006980.).

  8. 49 CFR 193.2001 - Scope of part.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES... LNG facilities used in the transportation of gas by pipeline that is subject to the pipeline safety...

  9. Postirradiation Testing Laboratory (327 Building)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kammenzind, D.E.

    A Standards/Requirements Identification Document (S/RID) is the total list of the Environment, Safety and Health (ES and H) requirements to be implemented by a site, facility, or activity. These requirements are appropriate to the life cycle phase to achieve an adequate level of protection for worker and public health and safety, and the environment during design, construction, operation, decontamination and decommissioning, and environmental restoration. S/RlDs are living documents, to be revised appropriately based on change in the site`s or facility`s mission or configuration, a change in the facility`s life cycle phase, or a change to the applicable standards/requirements. S/RIDs encompassmore » health and safety, environmental, and safety related safeguards and security (S and S) standards/requirements related to the functional areas listed in the US Department of Energy (DOE) Environment, Safety and Health Configuration Guide. The Fluor Daniel Hanford (FDH) Contract S/RID contains standards/requirements, applicable to FDH and FDH subcontractors, necessary for safe operation of Project Hanford Management Contract (PHMC) facilities, that are not the direct responsibility of the facility manager (e.g., a site-wide fire department). Facility S/RIDs contain standards/requirements applicable to a specific facility that are the direct responsibility of the facility manager. S/RlDs are prepared by those responsible for managing the operation of facilities or the conduct of activities that present a potential threat to the health and safety of workers, public, or the environment, including: Hazard Category 1 and 2 nuclear facilities and activities, as defined in DOE 5480.23. Selected Hazard Category 3 nuclear, and Low Hazard non-nuclear facilities and activities, as agreed upon by RL. The Postirradiation Testing Laboratory (PTL) S/RID contains standards/ requirements that are necessary for safe operation of the PTL facility, and other building/areas that are the direct responsibility of the specific facility manager. The specific DOE Orders, regulations, industry codes/standards, guidance documents and good industry practices that serve as the basis for each element/subelement are identified and aligned with each subelement.« less

  10. Letter to the editor regarding "GRAS from the ground up: Review of the Interim Pilot Program for GRAS notification" by.

    PubMed

    Sewalt, Vincent; LaMarta, James; Shanahan, Diane; Gregg, Lori; Carrillo, Roberto

    2017-09-01

    Present letter is aimed at clarifying some critical points highlighted by Hanlon et al. regarding the common knowledge element of the safety of food enzymes in support of their GRAS designation. Particularly, we outline the development of peer-reviewed, generally recognized safety evaluation methodology for microbial enzymes and its adoption by the enzyme industry, which provides the US FDA with a review framework for enzyme GRAS Notices. This approach may serve as a model to other food ingredient categories for a scientifically sound, rigorous, and transparent application of the GRAS concept. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. 25 CFR 559.7 - May the Chairman request Indian lands or environmental and public health and safety documentation...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and public health and safety documentation regarding any gaming place, facility, or location where... environmental and public health and safety documentation regarding any gaming place, facility, or location where gaming will occur? A tribe shall provide Indian lands or environmental and public health and safety...

  12. 25 CFR 559.7 - May the Chairman request Indian lands or environmental and public health and safety documentation...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... and public health and safety documentation regarding any gaming place, facility, or location where... environmental and public health and safety documentation regarding any gaming place, facility, or location where gaming will occur? A tribe shall provide Indian lands or environmental and public health and safety...

  13. 25 CFR 559.7 - May the Chairman request Indian lands or environmental and public health and safety documentation...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and public health and safety documentation regarding any gaming place, facility, or location where... environmental and public health and safety documentation regarding any gaming place, facility, or location where gaming will occur? A tribe shall provide Indian lands or environmental and public health and safety...

  14. ICPS Removal from Shipping Container

    NASA Image and Video Library

    2017-03-09

    Inside the United Launch Alliance (ULA) Horizontal Integration Facility at Cape Canaveral Air Force Station in Florida, a crane lifts the shipping container cover away from the Interim Cryogenic Propulsion Stage (ICPS) for NASA's Space Launch System rocket, followed by the ICPS bring removed and placed on a work stand for processing. The ICPS is the first integrated piece of flight hardware to arrive for the SLS. The ICPS arrived from the ULA facility in Decatur, Alabama. The ICPS is the in-space stage that is located toward the top of the rocket, between the Launch Vehicle Stage Adapter and the Orion Spacecraft Adapter. It will provide some of the in-space propulsion during Orion's first flight test atop the SLS on Exploration Mission 1.

  15. 3S (Safeguards, Security, Safety) based pyroprocessing facility safety evaluation plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ku, J.H.; Choung, W.M.; You, G.S.

    The big advantage of pyroprocessing for the management of spent fuels against the conventional reprocessing technologies lies in its proliferation resistance since the pure plutonium cannot be separated from the spent fuel. The extracted materials can be directly used as metal fuel in a fast reactor, and pyroprocessing reduces drastically the volume and heat load of the spent fuel. KAERI has implemented the SBD (Safeguards-By-Design) concept in nuclear fuel cycle facilities. The goal of SBD is to integrate international safeguards into the entire facility design process since the very beginning of the design phase. This paper presents a safety evaluationmore » plan using a conceptual design of a reference pyroprocessing facility, in which 3S (Safeguards, Security, Safety)-By-Design (3SBD) concept is integrated from early conceptual design phase. The purpose of this paper is to establish an advanced pyroprocessing hot cell facility design concept based on 3SBD for the successful realization of pyroprocessing technology with enhanced safety and proliferation resistance.« less

  16. Authorization basis supporting documentation for plutonium finishing plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    King, J.P., Fluor Daniel Hanford

    1997-03-05

    The identification and definition of the authorization basis for the Plutonium Finishing Plant (PFP) facility and operations are essential for compliance to DOE Order 5480.21, Unreviewed Safety Questions. The authorization basis, as defined in the Order, consists of those aspects of the facility design basis, i.e., the structures, systems and components (SSCS) and the operational requirements that are considered to be important to the safety of operations and are relied upon by DOE to authorize operation of the facility. These facility design features and their function in various accident scenarios are described in WHC-SD-CP-SAR-021, Plutonium Finishing Plant Final Safety Analysismore » Report (FSAR), Chapter 9, `Accident Analysis.` Figure 1 depicts the relationship of the Authorization Basis to its components and other information contained in safety documentation supporting the Authorization Basis. The PFP SSCs that are important to safety, collectively referred to as the `Safety Envelope` are discussed in various chapters of the FSAR and in WHC-SD-CP-OSR-010, Plutonium Finishing Plant Operational Safety Requirements. Other documents such as Criticality Safety Evaluation Reports (CSERS) address and support some portions of the Authorization Basis and Safety Envelope.« less

  17. 75 FR 33899 - Advisory Committee on Structural Safety of Department of Veterans Affairs Facilities; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... Construction & Facilities Management (00CFM1A), Department of Veterans Affairs, 810 Vermont Avenue, NW... Affairs Facilities; Notice of Meeting The Department of Veterans Affairs (VA) gives notice under Public... Safety of Department of Veterans Affairs Facilities will be held on June 24-25, 2010, in Room 442, Export...

  18. 76 FR 21108 - Advisory Committee on Structural Safety of Department of Veterans Affairs Facilities; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... Quality Service, Office of Construction and Facilities Management (00CFM1A), Department of Veterans... Affairs Facilities; Notice of Meeting The Department of Veterans Affairs (VA) gives notice under Public... Safety of Department of Veterans Affairs Facilities will be held on May 12-13, 2011, in Room 442, at the...

  19. Meat Entree Operation Guides Developed for Use in Fort Lee Interim Central Food Preparation Facility

    DTIC Science & Technology

    1978-11-01

    ROAST L -10-2 IN G RED IEN...OPERATION.AL GUIDE FOR B A R B E U JE f) CHICKEN INGREDIENTS & BATCH SIZE L -128 S tandard S erv:ing: 8 o f 2 p cs. E st. P rep T im e: 5. 5 hours 1...8217 ( · - · - - · · - - - . - - ~ - . . , L A B E L E R ( 7 0 ) ) ~ ~ ( ~ P A L L E T I Z E , , . OPERATIONAL GUIDE FOR CHICKEN CACCIATORE L -130

  20. Meat Entree Item Production Guides Developed for Use in Ft. Lee Interim Central Food Preparation Facility

    DTIC Science & Technology

    1975-03-01

    serves 8). 10. Add cooked dough . (See topping procedure). 11. Cover, label and place in blast freezer. Totals Rotes: 1. Reheating...3. Gradually add cold water and mix only enough to form a soft dough . 4. Place dough on a lightly floured board, kneeding lightly about 1...minute or until dough Is smooth. 5. Roll out to a uniform thickness of 1/4 inch. 6. Cut into 2 i/4-inch diameter biscuits. 7. Bake for 15 minutes in

  1. ICPS Turnover GSDO Employee Event

    NASA Image and Video Library

    2017-11-07

    Mike Bolger, Ground Systems Development and Operations Program manager at NASA's Kennedy Space Center, speaks to guests during a ceremony in the high bay of the Space Station Processing Facility. The event marked the milestone of the Space Launch System rocket's Interim Cryogenic Propulsion Stage (ICPS) being turned over from NASA's Spacecraft/Payload Integration and Evolution organization to the spaceport's Ground Systems Development and Operations directorate. The ICPS is the first integrated piece of flight hardware to arrive in preparation for the uncrewed Exploration Mission-1.

  2. IUS/TUG orbital operations and mission support study. Volume 4: Project planning data

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Planning data are presented for the development phases of interim upper stage (IUS) and tug systems. Major project planning requirements, major event schedules, milestones, system development and operations process networks, and relevant support research and technology requirements are included. Topics discussed include: IUS flight software; tug flight software; IUS/tug ground control center facilities, personnel, data systems, software, and equipment; IUS mission events; tug mission events; tug/spacecraft rendezvous and docking; tug/orbiter operations interface, and IUS/orbiter operations interface.

  3. Laser Induced Fluorescence Detection of Gums in Jet Fuels

    DTIC Science & Technology

    1992-05-01

    Classification) Laser Induced Fluorescence Detection of GLus in Jet Fuels 12 PERSONAL AUTHOR(S) David W. Naegeli and Ralph H. Hill 13a. TYPE OF REPORT 13b...degraded jet fuel.( ) 47 REFERENCES 1. Fodor, G.E.; Naegeli , D.W.; Kohl, K.B.; Cuellar, J.P., Jr., Interim Report BFLRF No. 199, AD A163590, Belvoir Fuels...and Lubricants Research Facility, Southwest Research Institute, San Antonio, TX, June 1985. 2. Fodor, G.E.; Naegeli , D.W., Proceedings of the 2nd

  4. Advancement of High Resolution Radar Polarimetry in Target Verses Clutter Detection, Discrimination, Classification: A. Basic Theory and Modeling of Polarimetric Clutter Phenomenology.

    DTIC Science & Technology

    1988-07-15

    the interim period, polarimetLic measurement data collected at other DOD/NATO/Industrial R/D/M facilities will be used. These basic studies will be...the polarization sphere and its spread can he related either to the coherency factor or the depolarization factor plus descriptive parameters of the...careful study of the concluding sections outlining the overall scenario of solved and unsolved problems. Here, we also refer to the recent report (Dec

  5. Systems special investigation group

    NASA Technical Reports Server (NTRS)

    1991-01-01

    An interim report concerning the Long Duration Exposure Facility (LDEF) is presented by a Boeing Systems special investigation group (SIG). The SIG activities were divided into five engineering disciplines: electrical, mechanical, optics, thermal, and batteries/solar cells. The responsibilities of the SIG included the following areas: support de-integration at Kennedy Space Center (KSC); testing of hardware at Boeing; review of principal investigator (PI) test plans and test results; support of test activities at PI labs; and collation of all test results into the SIG database.

  6. Report to Congress on innovative safety and security technology solutions for alternative transportation facilities

    DOT National Transportation Integrated Search

    2017-05-01

    This research collected information on the frequency and impact of safety and security incidents (threats) at selected facilities and identified priority incidents at each facility. A customized all hazards approach was used to determine the ha...

  7. Safety Management for Water Play Facilities.

    ERIC Educational Resources Information Center

    Thompson, Claude

    1986-01-01

    Modern aquatic facilities, which include wave pools, water slides, and shallow water activity play pools, have a greater potential for injuries and lawsuits than conventional swimming pools. This article outlines comprehensive safety management for such facilities, including potential accident identification and injury control planning. (MT)

  8. 76 FR 11764 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... Defense Nuclear Facilities Safety Board's public hearing and meeting described below. Interested persons... the matters to be considered. TIME AND DATE OF MEETING: 9 a.m., March 31, 2011. PLACE: Defense Nuclear...

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Azar, Miguel; Gardner, Donald A.; Taylor, Edward R.

    Exelon Nuclear (Exelon) designed and constructed an Interim Radwaste Storage Facility (IRSF) in the mid-1980's at LaSalle County Nuclear Station (LaSalle). The facility was designed to store low-level radioactive waste (LLRW) on an interim basis, i.e., up to five years. The primary reason for the IRSF was to offset lack of disposal in case existing disposal facilities, such as the Southeast Compact's Barnwell Disposal Facility in Barnwell, South Carolina, ceased accepting radioactive waste from utilities not in the Southeast Compact. Approximately ninety percent of the Radwaste projected to be stored in the LaSalle IRSF in that period of time wasmore » Class A, with the balance being Class B/C waste. On July 1, 2008 the Barnwell Disposal Facility in the Southeast Compact closed its doors to out of- compact Radwaste, which precluded LaSalle from shipping Class B/C Radwaste to an outside disposal facility. Class A waste generated by LaSalle is still able to be disposed at the 'Envirocare of Utah LLRW Disposal Complex' in Clive, Utah. Thus the need for utilizing the LaSalle IRSF for storing Class B/C Radwaste for an extended period, perhaps life-of-plant or more became apparent. Additionally, other Exelon Midwest nuclear stations located in Illinois that did not build an IRSF heretofore also needed extended Radwaste storage. In early 2009, Exelon made a decision to forward Radwaste from the Byron Nuclear Station (Byron), Braidwood Nuclear Station (Braidwood), and Clinton Nuclear Station (Clinton) to LaSalle's IRSF. As only Class B/C Radwaste would need to be forwarded to LaSalle, the original volumetric capacity of the LaSalle IRSF was capable of handling the small number of additional expected shipments annually from the Exelon sister nuclear stations in Illinois. Forwarding Class B/C Radwaste from the Exelon sister nuclear stations in Illinois to LaSalle would require an amendment to the LaSalle Station operating license. Exelon submitted the License Amendment Request (LAR) to NRC on January 6, 2010; NRC approved the LAR on July 21, 2011. A similar decision was made by Exelon in early 2009 to forward Radwaste from Limerick Nuclear Station to its sister station, the Peach Bottom Atomic Power Station; both in Pennsylvania. A LAR submittal to the NRC was also provided and NRC approval was received in 2011. (authors)« less

  10. The capacity of aquatic macrophytes for phytoremediation and their disposal with specific reference to water hyacinth.

    PubMed

    Newete, Solomon W; Byrne, Marcus J

    2016-06-01

    The actual amount of fresh water readily accessible for use is <1 % of the total amount of water on earth, and is expected to shrink further due to the projected growth of the population by a third in 2050. Worse yet are the major issues of water pollution, including mining and industrial waste which account for the bulk of contamination sources. The use of aquatic macrophytes as a cost-effective and eco-friendly tool for phytoremediation is well documented. However, little is known about the fate of those plants after phytoremediation. This paper reviews the options for safe disposal of waste plant biomass after phytoremediation. Among the few mentioned in the literature are briquetting, incineration and biogasification. The economic viability of such processes and the safety of their economic products for domestic use are however, not yet established. Over half of the nations in the world are involved in mining of precious metals, and tailings dams are the widespread legacy of such activities. Thus, the disposal of polluted plant biomass onto mine storage facilities such as tailing dams could be an interim solution. There, the material can act as mulch for the establishment of stabilizing vegetation and suppress dust. Plant decomposition might liberate its contaminants, but in a site where containment is a priority.

  11. 10 CFR 1703.105 - Requests for board records not available through the public reading room (FOIA requests).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... public reading room (FOIA requests). 1703.105 Section 1703.105 Energy DEFENSE NUCLEAR FACILITIES SAFETY... address for such requests is: Designated FOIA Officer, Defense Nuclear Facilities Safety Board, 625... pertain to an immediate source of risk to the public health and safety or worker safety at a defense...

  12. 10 CFR 1703.105 - Requests for board records not available through the public reading room (FOIA requests).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... public reading room (FOIA requests). 1703.105 Section 1703.105 Energy DEFENSE NUCLEAR FACILITIES SAFETY... address for such requests is: Designated FOIA Officer, Defense Nuclear Facilities Safety Board, 625... pertain to an immediate source of risk to the public health and safety or worker safety at a defense...

  13. 10 CFR 1703.105 - Requests for board records not available through the public reading room (FOIA requests).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... public reading room (FOIA requests). 1703.105 Section 1703.105 Energy DEFENSE NUCLEAR FACILITIES SAFETY... address for such requests is: Designated FOIA Officer, Defense Nuclear Facilities Safety Board, 625... pertain to an immediate source of risk to the public health and safety or worker safety at a defense...

  14. 10 CFR 1703.105 - Requests for board records not available through the public reading room (FOIA requests).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... public reading room (FOIA requests). 1703.105 Section 1703.105 Energy DEFENSE NUCLEAR FACILITIES SAFETY... address for such requests is: Designated FOIA Officer, Defense Nuclear Facilities Safety Board, 625... pertain to an immediate source of risk to the public health and safety or worker safety at a defense...

  15. 10 CFR 1703.105 - Requests for board records not available through the public reading room (FOIA requests).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... public reading room (FOIA requests). 1703.105 Section 1703.105 Energy DEFENSE NUCLEAR FACILITIES SAFETY... address for such requests is: Designated FOIA Officer, Defense Nuclear Facilities Safety Board, 625... pertain to an immediate source of risk to the public health and safety or worker safety at a defense...

  16. Designing Effective Safety Signs, Based on a Study of Recall for Safety Signs.

    ERIC Educational Resources Information Center

    Berry, Dennis W.

    Aside from direct supervision at a recreational facility, safety signs, if designed properly, are the most effective approach to facility safety. This study was conducted to investigate the effectiveness of various sign designs: (l) multiple concepts with text; (2) single concept with text; and (3) single concept with graphics. A discussion of…

  17. 30 CFR 57.6160 - Main facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Explosives Storage... facilities will not prevent escape from the mine, or cause detonation of the contents of another storage...

  18. Limited-scope probabilistic safety analysis for the Los Alamos Meson Physics Facility (LAMPF)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharirli, M.; Rand, J.L.; Sasser, M.K.

    1992-01-01

    The reliability of instrumentation and safety systems is a major issue in the operation of accelerator facilities. A probabilistic safety analysis was performed or the key safety and instrumentation systems at the Los Alamos Meson Physics Facility (LAMPF). in Phase I of this unique study, the Personnel Safety System (PSS) and the Current Limiters (XLs) were analyzed through the use of the fault tree analyses, failure modes and effects analysis, and criticality analysis. Phase II of the program was done to update and reevaluate the safety systems after the Phase I recommendations were implemented. This paper provides a brief reviewmore » of the studies involved in Phases I and II of the program.« less

  19. Limited-scope probabilistic safety analysis for the Los Alamos Meson Physics Facility (LAMPF)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharirli, M.; Rand, J.L.; Sasser, M.K.

    1992-12-01

    The reliability of instrumentation and safety systems is a major issue in the operation of accelerator facilities. A probabilistic safety analysis was performed or the key safety and instrumentation systems at the Los Alamos Meson Physics Facility (LAMPF). in Phase I of this unique study, the Personnel Safety System (PSS) and the Current Limiters (XLs) were analyzed through the use of the fault tree analyses, failure modes and effects analysis, and criticality analysis. Phase II of the program was done to update and reevaluate the safety systems after the Phase I recommendations were implemented. This paper provides a brief reviewmore » of the studies involved in Phases I and II of the program.« less

  20. Interim reliability evaluation program, Browns Ferry 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mays, S.E.; Poloski, J.P.; Sullivan, W.H.

    1981-01-01

    Probabilistic risk analysis techniques, i.e., event tree and fault tree analysis, were utilized to provide a risk assessment of the Browns Ferry Nuclear Plant Unit 1. Browns Ferry 1 is a General Electric boiling water reactor of the BWR 4 product line with a Mark 1 (drywell and torus) containment. Within the guidelines of the IREP Procedure and Schedule Guide, dominant accident sequences that contribute to public health and safety risks were identified and grouped according to release categories.

  1. Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission.

    PubMed

    Lioy, Paul J; Hauser, Russ; Gennings, Chris; Koch, Holger M; Mirkes, Philip E; Schwetz, Bernard A; Kortenkamp, Andreas

    2015-01-01

    The Consumer Product Safety Commission (CPSC) convened a Chronic Hazard Advisory Panel (CHAP) on Phthalates found in children's toys, and childcare products, and in products used by women of childbearing age. The CHAP conducted a risk assessment on phthalates and phthalate substitutes, and made recommendations to either ban, impose an interim ban, or allow the continued use of phthalates and phthalate substitutes in the above products. After a review of the literature, the evaluation included toxic end points of primary concern, biomonitoring results, extant exposure reconstruction, and epidemiological results. The health end points chosen were associated with the rat phthalate syndrome, which is characterized by malformations of the epididymis, vas deferens, seminal vesicles, prostate, external genitalia (hypospadias), and by cryptorchidism (undescended testes), retention of nipples/areolae, and demasculinization (~incomplete masculinization) of the perineum, resulting in reduced anogenital distance. Risk assessment demonstrated that some phthalates should be permanently banned, removed from the banned list, or remain interim banned. Biomonitoring and toxicology data provided the strongest basis for a mixture risk assessment. In contrast, external exposure data were the weakest and need to be upgraded for epidemiological studies and risk assessments. Such studies would focus on routes and sources. The review presents recommendations and uncertainties.

  2. Effect of a Manager Training and Certification Program on Food Safety and Hygiene in Food Service Operations

    PubMed Central

    Kassa, Hailu; Silverman, Gary S.; Baroudi, Karim

    2010-01-01

    Food safety is an important public health issue in the U.S. Eating at restaurants and other food service facilities increasingly has been associated with food borne disease outbreaks. Food safety training and certification of food mangers has been used as a method for reducing food safety violations at food service facilities. However, the literature is inconclusive about the effectiveness of such training programs for improving food safety and protecting consumer health. The purpose of this study was to examine the effect of food manger training on reducing food safety violations. We examined food inspection reports from the Toledo/Lucas County Health Department (Ohio) from March 2005 through February 2006 and compared food hygiene violations between food service facilities with certified and without certified food managers. We also examined the impact on food safety of a food service facility being part of a larger group of facilities. Restaurants with trained and certified food managers had significantly fewer critical food safety violations but more non-critical violations than restaurants without certified personnel. Institutional food service facilities had significantly fewer violations than restaurants, and the number of violations did not differ as a function of certification. Similarly, restaurants with many outlets had significantly fewer violations than restaurants with fewer outlets, and training was not associated with lower numbers of violations from restaurants with many outlets. The value of having certified personnel was only observed in independent restaurants and those with few branches. This information may be useful in indicating where food safety problems are most likely to occur. Furthermore, we recommend that those characteristics of institutional and chain restaurants that result in fewer violations should be identified in future research, and efforts made to apply this knowledge at the level of individual restaurants. PMID:20523880

  3. Effect of a manager training and certification program on food safety and hygiene in food service operations.

    PubMed

    Kassa, Hailu; Silverman, Gary S; Baroudi, Karim

    2010-05-06

    Food safety is an important public health issue in the U.S. Eating at restaurants and other food service facilities increasingly has been associated with food borne disease outbreaks. Food safety training and certification of food mangers has been used as a method for reducing food safety violations at food service facilities. However, the literature is inconclusive about the effectiveness of such training programs for improving food safety and protecting consumer health. The purpose of this study was to examine the effect of food manger training on reducing food safety violations. We examined food inspection reports from the Toledo/Lucas County Health Department (Ohio) from March 2005 through February 2006 and compared food hygiene violations between food service facilities with certified and without certified food managers. We also examined the impact on food safety of a food service facility being part of a larger group of facilities.Restaurants with trained and certified food managers had significantly fewer critical food safety violations but more non-critical violations than restaurants without certified personnel. Institutional food service facilities had significantly fewer violations than restaurants, and the number of violations did not differ as a function of certification. Similarly, restaurants with many outlets had significantly fewer violations than restaurants with fewer outlets, and training was not associated with lower numbers of violations from restaurants with many outlets. The value of having certified personnel was only observed in independent restaurants and those with few branches. This information may be useful in indicating where food safety problems are most likely to occur. Furthermore, we recommend that those characteristics of institutional and chain restaurants that result in fewer violations should be identified in future research, and efforts made to apply this knowledge at the level of individual restaurants.

  4. 30 CFR 75.1712-10 - Underground sanitary facilities; maintenance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Underground sanitary facilities; maintenance... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-10 Underground sanitary facilities; maintenance. Sanitary toilets shall be regularly maintained in...

  5. 30 CFR 75.1712-10 - Underground sanitary facilities; maintenance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Underground sanitary facilities; maintenance... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-10 Underground sanitary facilities; maintenance. Sanitary toilets shall be regularly maintained in...

  6. 30 CFR 75.1712-10 - Underground sanitary facilities; maintenance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Underground sanitary facilities; maintenance... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-10 Underground sanitary facilities; maintenance. Sanitary toilets shall be regularly maintained in...

  7. 30 CFR 75.1712-10 - Underground sanitary facilities; maintenance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Underground sanitary facilities; maintenance... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-10 Underground sanitary facilities; maintenance. Sanitary toilets shall be regularly maintained in...

  8. 30 CFR 75.1712-10 - Underground sanitary facilities; maintenance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Underground sanitary facilities; maintenance... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-10 Underground sanitary facilities; maintenance. Sanitary toilets shall be regularly maintained in...

  9. 75 FR 21605 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... depth federal safety management and oversight policies being developed by DOE and NNSA for defense... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Notice AGENCY: Defense Nuclear Facilities... in the Sunshine Act'' (5 U.S.C. 552b), notice is hereby given of the Defense Nuclear Facilities...

  10. The status of LILW disposal facility construction in Korea

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Min-Seok; Chung, Myung-Sub; Park, Kyu-Wan

    2013-07-01

    In this paper, we discuss the experiences during the construction of the first LILW disposal facility in South Korea. In December 2005, the South Korean Government designated Gyeongju-city as a host city of Low- and Intermediate-Level Radioactive Waste(LILW) disposal site through local referendums held in regions whose local governments had applied to host disposal facility in accordance with the site selection procedures. The LILW disposal facility is being constructed in Bongilri, Yangbuk-myeon, Gyeongju. The official name of the disposal facility is called 'Wolsong Low and Intermediate Level Radioactive Waste Disposal Center (LILW Disposal Center)'. It can dispose of 800,000 drumsmore » of radioactive wastes in a site of 2,100,000 square meters. At the first stage, LILW repository of underground silo type with disposal capacity of 100,000 drums is under construction expected to be completed by June of 2014. The Wolsong Low and Intermediate Level Radioactive Waste Disposal Center consists of surface facilities and underground facilities. The surface facilities include a reception and inspection facility, an interim storage facility, a radioactive waste treatment building, and supporting facilities such as main control center, equipment and maintenance shop. The underground facilities consist of a construction tunnel for transport of construction equipment and materials, an operation tunnel for transport of radioactive waste, an entrance shaft for workers, and six silos for final disposal of radioactive waste. As of Dec. 2012, the overall project progress rate is 93.8%. (authors)« less

  11. The Future of U.S. Nuclear Forces: Boom or Bust

    DTIC Science & Technology

    2007-03-30

    materials, and nuclear waste.45 The Defense Nuclear Facilities Safety Board (DNFSB) was established by Congress in 1988 as an independent federal...adequate protection of public health and safety" at DOE’s defense nuclear facilities .46 This 100- person agency looks at four areas of the nuclear weapons...47 A.J. Eggenberger, Sixteenth Annual Report to Congress (Washington DC: Defense Nuclear Facilities Safety Board, February 2006), 13; available

  12. The safety and effectiveness profile of eldecalcitol in a prospective, post-marketing observational study in Japanese patients with osteoporosis: interim report.

    PubMed

    Saito, Hitoshi; Kakihata, Hiroyuki; Nishida, Yosuke; Yatomi, Sawako; Nihojima, Shigeru; Kobayashi, Yumiko; Tabata, Hidehiro; Nomura, Makoto

    2017-07-01

    This large-scale post-marketing surveillance study was conducted to assess the safety and effectiveness of eldecalcitol treatment in patients with osteoporosis in a Japanese clinical setting. A total of 3567 patients with osteoporosis were enrolled and received eldecalcitol 0.75 μg/day for 12 months. For this interim report, 3285 patients were eligible for analysis. Mean age was 74.9 ± 8.7 years; 86.8 % (2854/3285) were women. There were 142 reported adverse drug reactions (ADRs) in 129 patients (3.92 % of the total 3285 patients): the most common were hypercalcemia and increased blood calcium (0.88 %), renal impairment (0.27 %), abdominal discomfort (0.24 %), constipation (0.24 %), and pruritus (0.24 %). The incidence of ADRs was 5.10 % in men and 3.74 % in women. Although 10 serious ADRs were reported in 9 patients (0.27 %), no clinically significant safety issues were identified. Incidence of hypercalcemia or increased blood calcium was 8.47 % in patients with renal impairment and only 0.74 % in patients without renal impairment. At last observation, the incidence of new vertebral and nonvertebral fractures was 2.44 % and 1.70 %, respectively. There was a significant increase in bone mineral density at the lumbar spine and distal radius. The bone turnover markers BAP, serum NTX, urinary NTX, and TRACP-5b were suppressed by eldecalcitol treatment in both sexes. In conclusion, consistent with the findings of the phase III pivotal clinical trial, eldecalcitol was shown to have a favorable safety profile and effectiveness in Japanese patients with osteoporosis. However, periodic measurements of serum calcium were required to prevent occurrence of hypercalcemia during eldecalcitol treatment, especially in patients with renal impairment.

  13. Erenumab (AMG 334) in episodic migraine: Interim analysis of an ongoing open-label study.

    PubMed

    Ashina, Messoud; Dodick, David; Goadsby, Peter J; Reuter, Uwe; Silberstein, Stephen; Zhang, Feng; Gage, Julia R; Cheng, Sunfa; Mikol, Daniel D; Lenz, Robert A

    2017-09-19

    To assess long-term safety and efficacy of anti-calcitonin gene-related peptide receptor erenumab in patients with episodic migraine (EM). Patients enrolled in a 12-week, double-blind, placebo-controlled clinical trial (NCT01952574) who continued in an open-label extension (OLE) study will receive erenumab 70 mg every 4 weeks for up to 5 years. This preplanned interim analysis, conducted after all participants had completed the 1-year open-label follow-up, evaluated changes in monthly migraine days (MMD), achievement of ≥50%, ≥75%, and 100% reductions, Headache Impact Test (HIT-6) score, Migraine-Specific Quality of Life (MSQ), Migraine Disability Assessment (MIDAS), and safety. Data reported as observed without imputation for missing data. Of 472 patients enrolled in the parent study, 383 continued in the OLE with a median exposure to erenumab of 575 days (range 28-822 days). Mean (SD) MMD were 8.8 (2.6) at parent study baseline, 6.3 (4.2) at week 12 (beginning of OLE), and 3.7 (4.0) at week 64 (mean change from baseline [reduction] of 5.0 days). At week 64, 65%, 42%, and 26% achieved ≥50%, ≥75%, and 100% reduction in MMD, respectively. Mean HIT-6 scores were 60.2 (6.3) at baseline and 51.7 (9.2) at week 64. MSQ and MIDAS improvements from baseline were maintained through week 64. Safety profiles during the OLE were similar to those in the double-blind phase, which overall were similar to placebo. One-year efficacy, supported by functional improvements and favorable safety and tolerability profiles, supports further investigation of erenumab as a preventive treatment in patients with EM. NCT01952574. This study provides Class IV evidence that for patients with episodic migraine, erenumab reduces long-term MMD and improves headache-related disability and migraine-specific quality of life. © 2017 American Academy of Neurology.

  14. 77 FR 40891 - Towing Safety Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... ``Recommendations for Safety Standards of Portable Facility Vapor Control Systems.'' (4) Period for public comment... teleconference to review and discuss a new Task Statement titled ``Recommendations for Safety Standards of Portable Facility Vapor Control Systems'' and to discuss the progress of open Task Statements. This meeting...

  15. 78 FR 41991 - Pipeline Safety: Potential for Damage to Pipeline Facilities Caused by Flooding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No...: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION: Notice; Issuance of Advisory... Gas and Hazardous Liquid Pipeline Systems. Subject: Potential for Damage to Pipeline Facilities Caused...

  16. 77 FR 63437 - Advisory Committee on Structural Safety of Department of Veterans Affairs Facilities, Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ..., Office of Construction & Facilities Management (003C2B), Department of Veterans Affairs, 425 I Street NW... Affairs Facilities, Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the... Safety of Department of Veterans Affairs Facilities will be held on October 29-30, 2012, in Room 6W405...

  17. 78 FR 21198 - Advisory Committee on Structural Safety of Department of Veterans Affairs Facilities; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... Construction and Facilities Management (003C2B), Department of Veterans Affairs, 810 Vermont Avenue NW... Affairs Facilities; Notice of Meeting The Department of Veterans Affairs (VA) gives notice under the... Safety of Department of Veterans Affairs Facilities will be held on April 25-26, 2013, in Room 6W405, 425...

  18. Analysis of Transportation Options for Commercial Spent Fuel in the U.S.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kalinina, Elena; Busch, Ingrid Karin

    The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S.more » Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF)...« less

  19. Approach for validating actinide and fission product compositions for burnup credit criticality safety analyses

    DOE PAGES

    Radulescu, Georgeta; Gauld, Ian C.; Ilas, Germina; ...

    2014-11-01

    This paper describes a depletion code validation approach for criticality safety analysis using burnup credit for actinide and fission product nuclides in spent nuclear fuel (SNF) compositions. The technical basis for determining the uncertainties in the calculated nuclide concentrations is comparison of calculations to available measurements obtained from destructive radiochemical assay of SNF samples. Probability distributions developed for the uncertainties in the calculated nuclide concentrations were applied to the SNF compositions of a criticality safety analysis model by the use of a Monte Carlo uncertainty sampling method to determine bias and bias uncertainty in effective neutron multiplication factor. Application ofmore » the Monte Carlo uncertainty sampling approach is demonstrated for representative criticality safety analysis models of pressurized water reactor spent fuel pool storage racks and transportation packages using burnup-dependent nuclide concentrations calculated with SCALE 6.1 and the ENDF/B-VII nuclear data. Furthermore, the validation approach and results support a recent revision of the U.S. Nuclear Regulatory Commission Interim Staff Guidance 8.« less

  20. Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: A phase 3, randomized controlled trial.

    PubMed

    Mahableshwarkar, Atul R; Calabrese, Joseph R; Macek, Thomas A; Budur, Kumar; Adefuye, Adedeji; Dong, Xinxin; Hanson, Elizabeth; Sachs, Gary S

    2017-10-15

    The optimal long-term management strategy for bipolar I disorder patients is not yet established. Evidence supports the rationale for circadian rhythm regulation to prevent mood episode relapse in bipolar patients. This study evaluated the efficacy and safety of a new sublingual formulation of the melatonin receptor agonist ramelteon (ramelteon SL) as adjunctive therapy in the maintenance treatment of bipolar I patients. In a double-blinded trial in the United States and Latin America, adult bipolar I disorder patients stable for ≥ 8 weeks before baseline and with a mood episode 8 weeks to 9 months before screening, were randomized to once-daily ramelteon SL 0.1mg (n = 164), 0.4mg (n = 160), or 0.8mg (n = 154), or placebo (n = 164), in addition to their existing treatment. The primary endpoint was time from randomization to relapse of symptoms. The prespecified futility criterion in a planned, unblinded, independent interim analysis was the failure of all ramelteon SL doses to achieve a conditional power ≥ 30% compared with placebo. No significant differences between any dose of ramelteon SL and placebo were observed. The study was terminated after meeting the futility criteria. Ramelteon SL was well tolerated, with a safety profile consistent with that for oral ramelteon. A low rate of relapse events precluded detection of any statistically significant difference between groups. The study failed to demonstrate the efficacy of ramelteon SL as adjunctive maintenance therapy for bipolar disorder. Interim analyses for futility in clinical studies are valuable in preventing unnecessary exposure of subjects to interventions. Copyright © 2017. Published by Elsevier B.V.

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