Pulsed metallic-plasma generators.

NASA Technical Reports Server (NTRS)

Gilmour, A. S., Jr.; Lockwood, D. L.

1972-01-01

A pulsed metallic-plasma generator is described which utilizes a vacuum arc as the plasma source. The arc is initiated on the surface of a consumable cathode which can be any electrically conductive material. Ignition is accomplished by using a current pulse to vaporize a portion of a conductive film on the surface of an insulator separating the cathode from the ignition electrode. The film is regenerated during the ensuing arc. Over 100 million ignition cycles have been accomplished by using four 0.125-in. diameter zinc cathodes operating in parallel and high-density aluminum-oxide insulators. Among the applications being investigated for the generator are metal deposition, vacuum pumping, electric propulsion, and high-power dc arc interruption.

Plasma motor generator system

NASA Technical Reports Server (NTRS)

Hite, Gerald E.

1987-01-01

The significant potential advantages of a plasma motor generator system over conventional systems for the generation of electrical power and propulsion for spacecraft in low Earth orbits warrants its further investigation. The two main components of such a system are a long insulated wire and the plasma generating hollow cathodes needed to maintain electrical contact with the ionosphere. Results of preliminary theoretical and experimental investigations of this system are presented. The theoretical work involved the equilibrium configurations of the wire and the nature of small oscillation about these equilibrium positions. A particularly interesting result was that two different configurations are allowed when the current is above a critical value. Experimental investigations were made of the optimal starting and running conditions for the proposed, low current hollow cathodes. Although optimal ranges of temperature, argon pressure and discharge voltage were identified, start up became progressively more difficult. This supposed depletion or contamination of the emissive surface could be countered by the addition of new emissive material.

D.C. - ARC plasma generator for nonequilibrium plasmachemical processes

NASA Astrophysics Data System (ADS)

Kvaltin, J.

1990-06-01

The analysis of conditions for generation of nonequilibrium plasma to plasmachemical processes is made and the design of d.c.-arc plasma generator on the base of integral criterion is suggested. The measurement of potentials on the plasma column of that generator is presented.

Plasma plume MHD power generator and method

DOEpatents

Hammer, James H.

1993-01-01

Highly-conducting plasma plumes are ejected across the interplanetary magnetic field from a situs that is moving relative to the solar wind, such as a spacecraft or an astral body, such as the moon, having no magnetosphere that excludes the solar wind. Discrete plasma plumes are generated by plasma guns at the situs extending in opposite directions to one another and at an angle, preferably orthogonal, to the magnetic field direction of the solar wind plasma. The opposed plumes are separately electrically connected to their source by a low impedance connection. The relative movement between the plasma plumes and the solar wind plasma creates a voltage drop across the plumes which is tapped by placing the desired electrical load between the electrical connections of the plumes to their sources. A portion of the energy produced may be used in generating the plasma plumes for sustained operation.

An amplitude modulated radio frequency plasma generator

NASA Astrophysics Data System (ADS)

Lei, Fan; Li, Xiaoping; Liu, Yanming; Liu, Donglin; Yang, Min; Xie, Kai; Yao, Bo

2017-04-01

A glow discharge plasma generator and diagnostic system has been developed to study the effects of rapidly variable plasmas on electromagnetic wave propagation, mimicking the plasma sheath conditions encountered in space vehicle reentry. The plasma chamber is 400 mm in diameter and 240 mm in length, with a 300-mm-diameter unobstructed clear aperture. Electron densities produced are in the mid 1010 electrons/cm3. An 800 W radio frequency (RF) generator is capacitively coupled through an RF matcher to an internally cooled stainless steel electrode to form the plasma. The RF power is amplitude modulated by a waveform generator that operates at different frequencies. The resulting plasma contains electron density modulations caused by the varying power levels. A 10 GHz microwave horn antenna pair situated on opposite sides of the chamber serves as the source and detector of probe radiation. The microwave power feed to the source horn is split and one portion is sent directly to a high-speed recording oscilloscope. On mixing this with the signal from the pickup horn antenna, the plasma-induced phase shift between the two signals gives the path-integrated electron density with its complete time dependent variation. Care is taken to avoid microwave reflections and extensive shielding is in place to minimize electronic pickup. Data clearly show the low frequency modulation of the electron density as well as higher harmonics and plasma fluctuations.

Modeling thrombin generation: plasma composition based approach.

PubMed

Brummel-Ziedins, Kathleen E; Everse, Stephen J; Mann, Kenneth G; Orfeo, Thomas

2014-01-01

Thrombin has multiple functions in blood coagulation and its regulation is central to maintaining the balance between hemorrhage and thrombosis. Empirical and computational methods that capture thrombin generation can provide advancements to current clinical screening of the hemostatic balance at the level of the individual. In any individual, procoagulant and anticoagulant factor levels together act to generate a unique coagulation phenotype (net balance) that is reflective of the sum of its developmental, environmental, genetic, nutritional and pharmacological influences. Defining such thrombin phenotypes may provide a means to track disease progression pre-crisis. In this review we briefly describe thrombin function, methods for assessing thrombin dynamics as a phenotypic marker, computationally derived thrombin phenotypes versus determined clinical phenotypes, the boundaries of normal range thrombin generation using plasma composition based approaches and the feasibility of these approaches for predicting risk.

Hollow laser plasma self-confined microjet generation

NASA Astrophysics Data System (ADS)

Sizyuk, Valeryi; Hassanein, Ahmed; CenterMaterials under Extreme Environment Team

2017-10-01

Hollow laser beam produced plasma (LPP) devices are being used for the generation of the self-confined cumulative microjet. Most important place by this LPP device construction is achieving of an annular distribution of the laser beam intensity by spot. An integrated model is being developed to detailed simulation of the plasma generation and evolution inside the laser beam channel. The model describes in two temperature approximation hydrodynamic processes in plasma, laser absorption processes, heat conduction, and radiation energy transport. The total variation diminishing scheme in the Lax-Friedrich formulation for the description of plasma hydrodynamic is used. Laser absorption and radiation transport models on the base of Monte Carlo method are being developed. Heat conduction part on the implicit scheme with sparse matrixes using is realized. The developed models are being integrated into HEIGHTS-LPP computer simulation package. The integrated modeling of the hollow beam laser plasma generation showed the self-confinement and acceleration of the plasma microjet inside the laser channel. It was found dependence of the microjet parameters including radiation emission on the hole and beam radiuses ratio. This work is supported by the National Science Foundation, PIRE project.

Analysis of plasmas generated by fission fragments. [nuclear pumped lasers and helium plasma

NASA Technical Reports Server (NTRS)

Deese, J. E.; Hassan, H. A.

1977-01-01

A kinetic model is developed for a plasma generated by fission fragments and the results are employed to study helium plasma generated in a tube coated with fissionable material. Because both the heavy particles and electrons play important roles in creating the plasma, their effects are considered simultaneously. The calculations are carried out for a range of neutron fluxes and pressures. In general, the predictions of the theory are in good agreement with available intensity measurements. Moreover, the theory predicts the experimentally measured inversions. However, the calculated gain coefficients are such that lasing is not expected to take place in a helium plasma generated by fission fragments. The effects of an externally applied electric field are also considered.

Back-diffusion plasma generator for ionosphere study

NASA Astrophysics Data System (ADS)

Fang, H. K.; Oyama, K.-I.; Chen, A. B.

2017-11-01

To produce ionospheric plasma environments at ground level is essential to get information not only for the development of CubeSat-class spacecraft but also for the design of ionospheric plasma instruments and to confirm their performance. In this paper, we describe the principle of plasma generation and characteristics of the back-diffusion plasma source, which can produce in-lab plasma similar to the Earth’s ionosphere, E and F regions, conditions of electron and ion temperature and density. The ion and electron energy distributions of the plasma generated by a back-diffusion source are measured by means of a cleaned Langmuir probe and gridded particle energy analyzers. The ion motion in front of the source is investigated by a hard-sphere collision model in SIMION software and the simulation results are comparable with the findings of our experiment. Furthermore, plasma densities and ion temperatures at different positions in front of the source are also demonstrated. The back-diffusion source has been accommodated for ionospheric plasma productions in several Asian institutes. The plasma characteristics of the source shown in this paper will benefit space research groups in the development of space plasma instruments.

Plasma cell treatment device Plasma-on-Chip: Monitoring plasma-generated reactive species in microwells

PubMed Central

Oh, Jun-Seok; Kojima, Shinya; Sasaki, Minoru; Hatta, Akimitsu; Kumagai, Shinya

2017-01-01

We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use in cell treatment, and 3) through-holes (microchannels) that connect each microwell with the microplasma region for RONS delivery. Here, we analysed the delivery of the RONS to the liquid culture medium stored in the microwells. We developed a simple experimental set-up using a microdevice and applied in situ ultraviolet absorption spectroscopy with high sensitivity for detecting RONS in liquid. The plasma-generated RONS were delivered into the liquid culture medium via the through-holes fabricated into the microdevice. The RONS concentrations were on the order of 10–100 μM depending on the size of the through-holes. In contrast, we found that the amount of dissolved oxygen was almost constant. To investigate the process of RONS generation, we numerically analysed the gas flow in the through-holes. We suggest that the circulating gas flow in the through-holes promotes the interaction between the plasma (ionised gas) and the liquid, resulting in enhanced RONS concentrations. PMID:28176800

Activated factor XI and tissue factor in aortic stenosis: Links with thrombin generation

PubMed Central

Luszczak, Joanna; Undas, Anetta; Gissel, Matthew; Olszowska, Maria; Butenas, Saulius

2011-01-01

Introduction In our previous studies we showed that a significant proportion of patients with various cardiovascular diseases have active tissue factor (TF) and factor (F)XIa in their plasma. Objective To evaluate these two proteins in plasma from patients with aortic stenosis (AS) and established their relationship with the severity of the disease. Methods Fifty-four consecutive patients with AS, including 38 (70.4%) severe AS patients, were studied. Plasma FXIa and TF activity were determined in clotting assays by measuring the response to inhibitory monoclonal antibodies. Results TF activity was detectible in plasma from 14 of 54 patients (25.9%), including 13 of 38 with severe AS (34.2%) and 1 of 16 (6.25%) with moderate AS (p=0.052). FXIa activity was found in 12 (22.2%) patients, mostly in individuals with severe AS (11 of 38, 28.9%, p=0.067). All 12 patients with circulating FXIa had active TF in their plasma as well. Severe AS patients with detectable TF had higher maximal (111±20 vs 97±16 mm Hg, p=0.02) and mean (61±12 vs 53±8 mm Hg, p=0.02) transvalvular gradient, compared with those without such activity in plasma. In severe AS patients with detectable active TF, prothrombin fragment 1.2, a thrombin generation marker, was higher than in patients without TF (375±122 vs. 207±64 pM, p<0.001). Conclusions Detectable FXIa and TF activity was observed for the first time in AS patients, primarily in severe ones. This activity correlates with thrombin generation in those patients. PMID:21519234

Solitary plasma rings and magnetic field generation involving gravity and differential rotation

NASA Astrophysics Data System (ADS)

Coppi, B.

2012-12-01

A new theoretical framework for describing how magnetic fields are generated and amplified is provided by finding magneto-gravitational modes that involve gravity, density gradients, and differential rotation in an essential way. Other factors, such as the presence of a high temperature particle population or of a temperature gradient, can contribute to their excitation. These modes identified by a linearized analysis are shown to be important for the evolution of plasma disks surrounding black holes toward different configurations. Since the nonlinear development of these modes can lead to radially localized regions with a relatively small differential rotation, new stationary structures have been identified, in the (fully) nonlinear limit, which are localized radially over regions with negligible gradients of the rotation frequency. These structures, characterized by solitary plasma rings, do not involve a pre-existing "seed" magnetic field, unlike other configurations found previously. The relevant magnetic energy density is comparable to the gravitationally confined plasma pressure. The "source" of these configurations is the combination of the gravitational force and of the plasma density gradient orthogonal to it that is an important factor in the theory of magneto-gravitational modes, another important factor being an anisotropy of the plasma pressure.

Role of plasma electrons in the generation of a gas discharge plasma

NASA Astrophysics Data System (ADS)

Gruzdev, V. A.; Zalesski, V. G.; Rusetski, I. S.

2012-12-01

The role of different ionization mechanisms in penning-type gas discharges used to generate an emitting plasma in plasma electron sources is considered. It is shown that, under certain conditions, a substantial contribution to the process of gas ionization is provided by plasma electrons.

High Frequency Plasma Generators for Ion Thrusters

NASA Technical Reports Server (NTRS)

Divergilio, W. F.; Goede, H.; Fosnight, V. V.

1981-01-01

The results of a one year program to experimentally adapt two new types of high frequency plasma generators to Argon ion thrusters and to analytically study a third high frequency source concept are presented. Conventional 30 cm two grid ion extraction was utilized or proposed for all three sources. The two plasma generating methods selected for experimental study were a radio frequency induction (RFI) source, operating at about 1 MHz, and an electron cyclotron heated (ECH) plasma source operating at about 5 GHz. Both sources utilize multi-linecusp permanent magnet configurations for plasma confinement. The plasma characteristics, plasma loading of the rf antenna, and the rf frequency dependence of source efficiency and antenna circuit efficiency are described for the RFI Multi-cusp source. In a series of tests of this source at Lewis Research Center, minimum discharge losses of 220+/-10 eV/ion were obtained with propellant utilization of .45 at a beam current of 3 amperes. Possible improvement modifications are discussed.

Atmospheric plasma generation for LCD panel cleaning

NASA Astrophysics Data System (ADS)

Kim, Gyu-Sik; Won, Chung-Yuen; Choi, Ju-Yeop; Yim, C. H.

2007-12-01

UV lamp systems have been used for cleaning of display panels of TFT LCD or Plasma Display Panel (PDP). However, the needs for high efficient cleaning and low cost made high voltage plasma cleaning techniques to be developed and to be improved. Dielectric-barrier discharges (DBDs), also referred to as barrier discharges or silent discharges have for a long time been exclusively related to ozone generation. In this paper, a 6kW high voltage plasma power supply system was developed for LCD cleaning. The -phase input voltage is rectified and then inverter system is used to make a high frequency pulse train, which is rectified after passing through a high-power transformer. Finally, bi-directional high voltage pulse switching circuits are used to generate the high voltage plasma. Some experimental results showed the usefulness of atmospheric plasma for LCD panel cleaning.

Cascade generation in Al laser induced plasma

NASA Astrophysics Data System (ADS)

Nagli, Lev; Gaft, Michael; Raichlin, Yosef; Gornushkin, Igor

2018-05-01

We found cascade IR generation in Al laser induced plasma. This generation includes doublet transitions 3s 25s 2S1/2 → 3s24p 2P1/2,3/2 → 3s24s 2S1/2; corresponding to strong lines at 2110 and 2117 nm, and much weaker lines at 1312-1315 nm. The 3s25s2S 1/2 starting IR generation level is directly pumped from the 3s23p 2P3/2 ground level. The starting level for UV generation at 396.2 nm (transitions 3s24s 2S1/2 → 4p 2P3/2) is populated due to the fast collisional processes in the plasma plume. These differences led to different time and special dependences on the lasing in the IR and UV spectral range within the aluminum laser induced plasma.

The effect of serum on monocyte tissue factor generation.

PubMed

Edwards, R L; Perla, D

1984-09-01

Human monocytes generate the procoagulant tissue factor (MTF) following exposure to a variety of immune stimuli in vitro. The generation of MTF is modified by T cells, lymphokines, and immunoregulatory lipoproteins, and recent studies have shown that MTF can be activated in an immune-specific manner following exposure to antigen. We have examined the role of serum factors in the regulation of MTF generation. Low concentrations (less than 1%) of heat-inactivated normal human serum greatly enhanced MTF generation in cultures of normal peripheral blood mononuclear cells. The stimulatory effect was observed in cultures of both unstimulated cells and cells exposed to bacterial lipopolysaccharide. Stimulation was not observed at high serum concentrations (greater than 10%) and could not be explained by endotoxin contamination or activation of the assay system. Stimulatory activity was present in plasma and BaSO4-adsorbed plasma as well as autologous and allogeneic serum, was not abolished by removal of serum lipoproteins, and did not require the presence of T cells for its expression. Sera from 28 different normal volunteers were screened for stimulatory activity and demonstrated a wide variation in potency. These results suggest that a potent factor is present in sera that enhances the expression of MTF activity in vitro. This factor is distinct from previously described lipoprotein regulators and may play a role in the initiation of coagulation in both normal hemostasis and pathologic states.

Slot-Antenna/Permanent-Magnet Device for Generating Plasma

NASA Technical Reports Server (NTRS)

Foster, John E.

2007-01-01

A device that includes a rectangular-waveguide/slot-antenna structure and permanent magnets has been devised as a means of generating a substantially uniform plasma over a relatively large area, using relatively low input power and a low gas flow rate. The device utilizes electron cyclotron resonance (ECR) excited by microwave power to efficiently generate plasma in a manner that is completely electrodeless in the sense that, in principle, there is no electrical contact between the plasma and the antenna. Plasmas generated by devices like this one are suitable for use as sources of ions and/or electrons for diverse material-processing applications (e.g., etching or deposition) and for ion thrusters. The absence of plasma/electrode contact essentially prevents plasma-induced erosion of the antenna, thereby also helping to minimize contamination of the plasma and of objects exposed to the plasma. Consequently, the operational lifetime of the rectangular-waveguide/ slot-antenna structure is long and the lifetime of the plasma source is limited by the lifetime of the associated charged-particle-extraction grid (if used) or the lifetime of the microwave power source. The device includes a series of matched radiating slot pairs that are distributed along the length of a plasma-source discharge chamber (see figure). This arrangement enables the production of plasma in a distributed fashion, thereby giving rise to a uniform plasma profile. A uniform plasma profile is necessary for uniformity in any electron- or ion-extraction electrostatic optics. The slotted configuration of the waveguide/ antenna structure makes the device scalable to larger areas and higher powers. All that is needed for scaling up is the attachment of additional matched radiating slots along the length of the discharge chamber. If it is desired to make the power per slot remain constant in scaling up, then the input microwave power must be increased accordingly. Unlike in prior ECR microwave plasma-generating

On-site SiH4 generator using hydrogen plasma generated in slit-type narrow gap

NASA Astrophysics Data System (ADS)

Takei, Norihisa; Shinoda, Fumiya; Kakiuchi, Hiroaki; Yasutake, Kiyoshi; Ohmi, Hiromasa

2018-06-01

We have been developing an on-site silane (SiH4) generator based on use of the chemical etching reaction between solid silicon (Si) and the high-density H atoms that are generated in high-pressure H2 plasma. In this study, we have developed a slit-type plasma source for high-efficiency SiH4 generation. High-density H2 plasma was generated in a narrow slit-type discharge gap using a 2.45 GHz microwave power supply. The plasma’s optical emission intensity distribution along the slit was measured and the resulting distribution was reflected by both the electric power distribution and the hydrogen gas flow. Because the Si etching rate strongly affects the SiH4 generation rate, the Si etching behavior was investigated with respect to variations in the experimental parameters. The weight etch rate increased monotonically with increasing input microwave power. However, the weight etch rate decreased with increasing H2 pressure and an increasing plasma gap. This reduction in the etch rate appears to be related to shrinkage of the plasma generation area because increased input power is required to maintain a constant plasma area with increasing H2 pressure and the increasing plasma gap. Additionally, the weight etch rate also increases with increasing H2 flow rate. The SiH4 generation rate of the slit-type plasma source was also evaluated using gas-phase Fourier transform infrared absorption spectroscopy and the material utilization efficiencies of both Si and the H2 gas for SiH4 gas formation were discussed. The main etch product was determined to be SiH4 and the developed plasma source achieved a SiH4 generation rate of 10 sccm (standard cubic centimeters per minute) at an input power of 900 W. In addition, the Si utilization efficiency exceeded 60%.

Method for generating a highly reactive plasma for exhaust gas aftertreatment and enhanced catalyst reactivity

DOEpatents

Whealton, John H.; Hanson, Gregory R.; Storey, John M.; Raridon, Richard J.; Armfield, Jeffrey S.; Bigelow, Timothy S.; Graves, Ronald L.

2001-01-01

A method for non-thermal plasma aftertreatment of exhaust gases the method comprising the steps of providing short risetime (about 40 ps), high frequency (about 5G hz), high power bursts of low-duty factor microwaves sufficient to generate a dielectric barrier discharge and passing a gas to treated through the discharge so as to cause dissociative reduction of the exhaust gases. The invention also includes a reactor for generating the non-thermal plasma.

Electrode assemblies, plasma apparatuses and systems including electrode assemblies, and methods for generating plasma

DOEpatents

Kong, Peter C; Grandy, Jon D; Detering, Brent A; Zuck, Larry D

2013-09-17

Electrode assemblies for plasma reactors include a structure or device for constraining an arc endpoint to a selected area or region on an electrode. In some embodiments, the structure or device may comprise one or more insulating members covering a portion of an electrode. In additional embodiments, the structure or device may provide a magnetic field configured to control a location of an arc endpoint on the electrode. Plasma generating modules, apparatus, and systems include such electrode assemblies. Methods for generating a plasma include covering at least a portion of a surface of an electrode with an electrically insulating member to constrain a location of an arc endpoint on the electrode. Additional methods for generating a plasma include generating a magnetic field to constrain a location of an arc endpoint on an electrode.

Plasma driven neutron/gamma generator

DOEpatents

Leung, Ka-Ngo; Antolak, Arlyn

2015-03-03

An apparatus for the generation of neutron/gamma rays is described including a chamber which defines an ion source, said apparatus including an RF antenna positioned outside of or within the chamber. Positioned within the chamber is a target material. One or more sets of confining magnets are also provided to create a cross B magnetic field directly above the target. To generate neutrons/gamma rays, the appropriate source gas is first introduced into the chamber, the RF antenna energized and a plasma formed. A series of high voltage pulses are then applied to the target. A plasma sheath, which serves as an accelerating gap, is formed upon application of the high voltage pulse to the target. Depending upon the selected combination of source gas and target material, either neutrons or gamma rays are generated, which may be used for cargo inspection, and the like.

Generation conditions of CW Diode Laser Sustained Plasma

NASA Astrophysics Data System (ADS)

Nishimoto, Koji; Matsui, Makoto; Ono, Takahiro

2016-09-01

Laser sustained plasma was generated using 1 kW class continuous wave diode laser. The laser beam was focused on the seed plasma generated by arc discharge in 1 MPa xenon lamp. The diode laser has advantages of high energy conversion efficiency of 80%, ease of maintenance, compact size and availability of conventional quartz based optics. Therefore, it has a prospect of further development compared with conventional CO2 laser. In this study, variation of the plasma shape caused by laser power is observed and also temperature distribution in the direction of plasma radius is measured by optical emission spectroscopy.

Impact of Pre-Plasma on Electron Generation and Transport in Laser Plasma Interactions

NASA Astrophysics Data System (ADS)

Peebles, Jonathan Lee

Relativistic laser plasma interactions in conjunction with an underdense pre-plasma have been shown to generate a two temperature component electron spectrum. The lower temperature component described by "ponderomotive scaling'" is relatively well known and understood and is useful for applications such as the fast ignition inertial confinement fusion scheme. The higher energy electrons generated due to pre-plasma are denoted as "super-ponderomotive" electrons and facilitate interesting and useful applications. These include but are not limited to table top particle acceleration and generating high energy protons, x-rays and neutrons from secondary interactions. This dissertation describes experimental and particle-in-cell computational studies of the electron spectra produced from interactions between short pulse high intensity lasers and controlled pre-plasma conditions. Experiments were conducted at 3 laser labs: Texas Petawatt (University of Texas at Austin), Titan (Lawrence Livermore National Laboratory) and OMEGA-EP (University of Rochester). These lasers have different capabilities, and multiple experiments were carried out in order to fully understand super-ponderomotive electron generation and transport in the high intensity laser regime (I > 1018 W/cm2). In these experiments, an additional secondary long pulse beam was used to generate different scale lengths of "injected" pre-plasma while the pulse length and intensity of the short pulse beam were varied. The temperature and quantity of super-ponderomotive electrons were monitored with magnetic spectrometers and inferred via bremsstrahlung spectrometers while trajectory was estimated via Cu-Kalpha imaging. The experimental and simulation data show that super-ponderomotive electrons require pulse lengths of at least 450 fs to be accelerated and that higher intensity interactions generate large magnetic fields which cause severe deflection of the super-ponderomotive electrons. Laser incidence angle is

Enhanced pair plasma generation in the relativistic transparency regime

NASA Astrophysics Data System (ADS)

Liu, W. Y.; Luo, W.; Yuan, T.; Yu, J. Y.; Chen, M.; Sheng, Z. M.

2017-10-01

Electron-positron ( e - e + ) pair plasma generation in the relativistic transparency regime in a thin foil with a fixed thickness irradiated by two counter-propagating laser pulses is investigated through multi-dimensional particle-in-cell simulations. It is shown that target transparency can significantly enhance the pair generation due to the formation of a stable standing wave. An optimum foil density of 200-280 n c (with nc being the critical plasma density of the incident laser at the wavelength of 1 μm) is found for enhanced e - e + pair generation for laser intensity around 10 PW. With such foil density, laser energy transformed to pair plasma formation is approximately four times higher than that with a foil density of 710 nc, while the laser energy transformed to γ-photons remains almost the same. Dense e - e + plasma with a density as high as 10 22 cm - 3 ( ≃ 10 n c ) can be produced accordingly. Comparison of pair plasma generation between cases with fundamental and double frequency driver lasers further demonstrates such an enhancement effect. It shows that when the duration of the laser pulse is relatively short, the double frequency driver can generate more pair plasmas due to the earlier excitation of relativistic transparency.

Ultra-High Intensity Magnetic Field Generation in Dense Plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisch, Nathaniel J.

2014-01-08

The main objective of this grant proposal was to explore the efficient generation of intense currents. Whereas the efficient generation of electric current in low-­energy-­density plasma has occupied the attention of the magnetic fusion community for several decades, scant attention has been paid to carrying over to high-­energy-­density plasma the ideas for steady-­state current drive developed for low-­energy-­density plasma, or, for that matter, to inventing new methodologies for generating electric current in high-­energy-­density plasma. What we proposed to do was to identify new mechanisms to accomplish current generation, and to assess the operation, physics, and engineering basis of new formsmore » of current drive in regimes appropriate for new fusion concepts.« less

A direct thrombin inhibitor suppresses protein C activation and factor Va degradation in human plasma: Possible mechanisms of paradoxical enhancement of thrombin generation.

PubMed

Kamisato, Chikako; Furugohri, Taketoshi; Morishima, Yoshiyuki

2016-05-01

We have demonstrated that antithrombin (AT)-independent thrombin inhibitors paradoxically increase thrombin generation (TG) in human plasma in a thrombomodulin (TM)- and protein C (PC)-dependent manner. We determined the effects of AT-independent thrombin inhibitors on the negative-feedback system, activation of PC and production and degradation of factor Va (FVa), as possible mechanisms underlying the paradoxical enhancement of TG. TG in human plasma containing 10nM TM was assayed by means of the calibrated automated thrombography. As an index of PC activation, plasma concentration of activated PC-PC inhibitor complex (aPC-PCI) was measured. The amounts of FVa heavy chain and its degradation product (FVa(307-506)) were examined by western blotting. AT-independent thrombin inhibitors, melagatran and dabigatran (both at 25-600nM) and 3-30μg/ml active site-blocked thrombin (IIai), increased peak levels of TG. Melagatran, dabigatran and IIai significantly decreased plasma concentration of aPC-PCI complex at 25nM or more, 75nM or more, and 10 and 30μg/ml, respectively. Melagatran (300nM) significantly increased FVa and decreased FVa(307-506). In contrast, a direct factor Xa inhibitor edoxaban preferentially inhibited thrombin generation (≥25nM), and higher concentrations were required to inhibit PC activation (≥150nM) and FVa degradation (300nM). The present study suggests that the inhibitions of protein C activation and subsequent degradation of FVa and increase in FVa by antithrombin-independent thrombin inhibitors may contribute to the paradoxical TG enhancement, and edoxaban may inhibit PC activation and FVa degradation as a result of TG suppression. Copyright © 2016 Elsevier Ltd. All rights reserved.

High density plasma gun generates plasmas at 190 kilometers per second

NASA Technical Reports Server (NTRS)

Espy, P. N.

1971-01-01

Gun has thin metal foil disc which positions or localizes gas to be ionized during electrical discharge cycle, overcoming major limiting factor in obtaining such plasmas. Expanding plasma front travels at 190 km/sec, compared to plasmas of 50 to 60 km/sec previously achieved.

Quarantine versus pathogen-reduced plasma-coagulation factor content and rotational thromboelastometry coagulation.

PubMed

Theusinger, Oliver M; Goslings, David; Studt, Jan-Dirk; Brand-Staufer, Brigitte; Seifert, Burkhardt; Spahn, Donat R; Frey, Beat M

2017-03-01

Different types of fresh-frozen plasma (FFP) exist, and the concentrations of plasma proteins vary between individuals and blood groups. Furthermore, processing may also influence the content. Quarantine-stored plasma (qFFP) and plasma that was pathogen-reduced using blood-safety (Intercept) technology (piFFP) were analyzed regarding procoagulant and anticoagulant hemostasis proteins, including endogenous thrombin (thrombin-generation) potential (ETP). Thirty-five samples of each type of FFP were analyzed using only male Blood Group O donors. FFP units were stored frozen for comparable periods of time before plasma protein content was assessed. Once the units were thawed, all tests were completed within 4 hours. The results are presented as means ± standard deviations or as median (minimum; maximum) and were compared using independent-sample t tests (significance, p < 0.01). Significantly higher concentrations of adintegrin-like and metalloprotease with thrombospondin type-13 motifs (ADAMTS13), fibrinogen, Factor (F)V, FVIII, FXIII, protein S, protein S activity, antithrombin, microvesicle (<900 nm), and α2 antiplasmin were observed in qFFP. The variability of factors was significantly lower in piFFP. Tissue factor (TF) at 1 picomolar (pM) exhibited significantly longer lag time, a lower peak, lower ETP, and a lower velocity index in qFFP compared with piFFP. In TF at 5 pM, significant differences in lag time (longer in qFFP), velocity index (lower in qFFP), and peak (lower in qFFP) were observed. Rotational thromboelastometry revealed a significantly longer (p = 0.002) clot-formation time with intrinsic thromboelastometry for piFFP and a significantly shorter clotting time (p = 0.004) with thromboelastometry fibrinogen testing for piFFP. Pathogen reduction reduces procoagulant and anticoagulant coagulation factors as well as variability. A thrombin-generation assay showed no reduced ETP and no supraphysiological thrombin generation. None of the

Edge plasma boundary layer generated by kink modes in tokamaks

NASA Astrophysics Data System (ADS)

Zakharov, Leonid E.

2011-06-01

This paper describes the structure of the electric current generated by external wall touching and free boundary kink modes at the plasma edge using the ideally conducting plasma model. Both kinds of modes generate δ-functional surface current at the plasma edge. Free boundary kink modes also perturb the core plasma current, which in the plasma edge compensates the difference between the δ-functional surface currents of free boundary and wall touching kink modes. In addition, the resolution of an apparent paradox with the pressure balance across the plasma boundary in the presence of the surface currents is provided.

Conceptual Design of Electron-Beam Generated Plasma Tools

NASA Astrophysics Data System (ADS)

Agarwal, Ankur; Rauf, Shahid; Dorf, Leonid; Collins, Ken; Boris, David; Walton, Scott

2015-09-01

Realization of the next generation of high-density nanostructured devices is predicated on etching features with atomic layer resolution, no damage and high selectivity. High energy electron beams generate plasmas with unique features that make them attractive for applications requiring monolayer precision. In these plasmas, high energy beam electrons ionize the background gas and the resultant daughter electrons cool to low temperatures via collisions with gas molecules and lack of any accelerating fields. For example, an electron temperature of <0.6 eV with densities comparable to conventional plasma sources can be obtained in molecular gases. The chemistry in such plasmas can significantly differ from RF plasmas as the ions/radicals are produced primarily by beam electrons rather than those in the tail of a low energy distribution. In this work, we will discuss the conceptual design of an electron beam based plasma processing system. Plasma properties will be discussed for Ar, Ar/N2, and O2 plasmas using a computational plasma model, and comparisons made to experiments. The fluid plasma model is coupled to a Monte Carlo kinetic model for beam electrons which considers gas phase collisions and the effect of electric and magnetic fields on electron motion. The impact of critical operating parameters such as magnetic field, beam energy, and gas pressure on plasma characteristics in electron-beam plasma processing systems will be discussed. Partially supported by the NRL base program.

Plasma generators, reactor systems and related methods

DOEpatents

Kong, Peter C [Idaho Falls, ID; Pink, Robert J [Pocatello, ID; Lee, James E [Idaho Falls, ID

2007-06-19

A plasma generator, reactor and associated systems and methods are provided in accordance with the present invention. A plasma reactor may include multiple sections or modules which are removably coupled together to form a chamber. Associated with each section is an electrode set including three electrodes with each electrode being coupled to a single phase of a three-phase alternating current (AC) power supply. The electrodes are disposed about a longitudinal centerline of the chamber and are arranged to provide and extended arc and generate an extended body of plasma. The electrodes are displaceable relative to the longitudinal centerline of the chamber. A control system may be utilized so as to automatically displace the electrodes and define an electrode gap responsive to measure voltage or current levels of the associated power supply.

Arc plasma generator of atomic driver for steady-state negative ion source.

PubMed

Ivanov, A A; Belchenko, Yu I; Davydenko, V I; Ivanov, I A; Kolmogorov, V V; Listopad, A A; Mishagin, V V; Putvinsky, S V; Shulzhenko, G I; Smirnov, A

2014-02-01

The paper reviews the results of development of steady-state arc-discharge plasma generator with directly heated LaB6 cathode. This arc-discharge plasma generator produces a plasma jet which is to be converted into an atomic one after recombination on a metallic plate. The plate is electrically biased relative to the plasma in order to control the atom energies. Such an intensive jet of hydrogen atoms can be used in negative ion sources for effective production of negative ions on a cesiated surface of plasma grid. All elements of the plasma generator have an augmented water cooling to operate in long pulse mode or in steady state. The thermo-mechanical stresses and deformations of the most critical elements of the plasma generator were determined by simulations. Magnetic field inside the discharge chamber was optimized to reduce the local power loads. The first tests of the steady-state arc plasma generator prototype have performed in long-pulse mode.

Time Resolved Temperature Measurement of Hypervelocity Impact Generated Plasma Using a Global Optimization Method

NASA Astrophysics Data System (ADS)

Hew, Y. M.; Linscott, I.; Close, S.

2015-12-01

Meteoroids and orbital debris, collectively referred to as hypervelocity impactors, travel between 7 and 72 km/s in free space. Upon their impact onto the spacecraft, the energy conversion from kinetic to ionization/vaporization occurs within a very brief timescale and results in a small and dense expanding plasma with a very strong optical flash. The radio frequency (RF) emission produced by this plasma can potentially lead to electrical anomalies within the spacecraft. In addition, space weather, such as solar activity and background plasma, can establish spacecraft conditions which can exaggerate the damages done by these impacts. During the impact, a very strong impact flash will be generated. Through the studying of this emission spectrum of the impact, we hope to study the impact generated gas cloud/plasma properties. The impact flash emitted from a ground-based hypervelocity impact test is long expected by many scientists to contain the characteristics of the impact generated plasma, such as plasma temperature and density. This paper presents a method for the time-resolved plasma temperature estimation using three-color visible band photometry data with a global pattern search optimization method. The equilibrium temperature of the plasma can be estimated using an optical model which accounts for both the line emission and continuum emission from the plasma. Using a global pattern search based optimizer, the model can isolate the contribution of the continuum emission versus the line emission from the plasma. The plasma temperature can thus be estimated. Prior to the optimization step, a Gaussian process is also applied to extract the optical emission signal out of the noisy background. The resultant temperature and line-to-continuum emission weighting factor are consistent with the spectrum of the impactor material and current literature.

Apparatus for generating quasi-free-space microwave-driven plasmas

NASA Astrophysics Data System (ADS)

Hoff, Brad W.; French, David M.; Reid, Remington R.; Lawrance, Julie E.; Lepell, P. David; Maestas, Sabrina S.

2016-03-01

An apparatus for generating quasi-free-space microwave-driven plasmas has been designed, constructed, and tested. The plasma is driven by a multi-kW, ˜5 GHz microwave beam focused at the center of a vacuum chamber using a Koch-type metal plate lens. Sustained plasma discharges have been generated in argon at pressures ranging from 150 to 200 mTorr, at beam power levels ranging from 5 to 10 kW, and at gas flow rates of approximately 200 SCCM.

Apparatus for generating quasi-free-space microwave-driven plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoff, Brad W.; French, David M.; Reid, Remington R.

An apparatus for generating quasi-free-space microwave-driven plasmas has been designed, constructed, and tested. The plasma is driven by a multi-kW, ∼5 GHz microwave beam focused at the center of a vacuum chamber using a Koch-type metal plate lens. Sustained plasma discharges have been generated in argon at pressures ranging from 150 to 200 mTorr, at beam power levels ranging from 5 to 10 kW, and at gas flow rates of approximately 200 SCCM.

Apparatus for generating quasi-free-space microwave-driven plasmas.

PubMed

Hoff, Brad W; French, David M; Reid, Remington R; Lawrance, Julie E; Lepell, P David; Maestas, Sabrina S

2016-03-01

An apparatus for generating quasi-free-space microwave-driven plasmas has been designed, constructed, and tested. The plasma is driven by a multi-kW, ∼5 GHz microwave beam focused at the center of a vacuum chamber using a Koch-type metal plate lens. Sustained plasma discharges have been generated in argon at pressures ranging from 150 to 200 mTorr, at beam power levels ranging from 5 to 10 kW, and at gas flow rates of approximately 200 SCCM.

Release kinetics of platelet-derived and plasma-derived growth factors from autologous plasma rich in growth factors.

PubMed

Anitua, Eduardo; Zalduendo, Mari Mar; Alkhraisat, Mohammad Hamdan; Orive, Gorka

2013-10-01

Many studies have evaluated the biological effects of platelet rich plasma reporting the final outcomes on cell and tissues. However, few studies have dealt with the kinetics of growth factor delivery by plasma rich in growth factors. Venous blood was obtained from three healthy volunteers and processed with PRGF-Endoret technology to prepare autologous plasma rich in growth factors. The gel-like fibrin scaffolds were then incubated in triplicate, in a cell culture medium to monitor the release of PDGF-AB, VEGF, HGF and IGF-I during 8 days of incubation. A leukocyte-platelet rich plasma was prepared employing the same technology and the concentrations of growth factors and interleukin-1β were determined after 24h of incubation. After each period, the medium was collected, fibrin clot was destroyed and the supernatants were stored at -80°C until analysis. The growth factor delivery is diffusion controlled with a rapid initial release by 30% of the bioactive content after 1h of incubation and a steady state release when almost 70% of the growth factor content has been delivered. Autologous fibrin matrix retained almost 30% of the amount of the growth factors after 8 days of incubation. The addition of leukocytes to the formula of platelet rich plasma did not increase the concentration of the growth factors, while it drastically increased the presence of pro-inflammatory IL-1β. Further studies employing an in vitro inflammatory model would be interesting to study the difference in growth factors and pro-inflammatory cytokines between leukocyte-free and leukocyte-rich platelet rich plasma. Copyright © 2013 Elsevier GmbH. All rights reserved.

Laser-pulse shape effects on magnetic field generation in underdense plasmas

NASA Astrophysics Data System (ADS)

Gopal, Krishna; Raja, Md. Ali; Gupta, Devki Nandan; Avinash, K.; Sharma, Suresh C.

2018-07-01

Laser pulse shape effect has been considered to estimate the self-generated magnetic field in laser-plasma interaction. A ponderomotive force based physical mechanism has been proposed to investigate the self-generated magnetic field for different spatial profiles of the laser pulse in inhomogeneous plasmas. The spatially inhomogeneous electric field of a laser pulse imparts a stronger ponderomotive force on plasma electrons. Thus, the stronger ponderomotive force associated with the asymmetric laser pulse generates a stronger magnetic field in comparison to the case of a symmetric laser pulse. Scaling laws for magnetic field strength with the laser and plasma parameters for different shape of the pulse have been suggested. Present study might be helpful to understand the plasma dynamics relevant to the particle trapping and injection in laser-plasma accelerators.

Analysis and characterization of microwave plasma generated with rectangular all-dielectric resonators

NASA Astrophysics Data System (ADS)

Kourtzanidis, K.; Raja, L. L.

2017-04-01

We report on a computational modeling study of small scale plasma discharge formation with rectangular dielectric resonators (DR). An array of rectangular dielectric slabs, separated by a gap of millimeter dimensions is used to provide resonant response when illuminated by an incident wave of 1.26 GHz. A coupled electromagnetic (EM) wave-plasma model is used to describe the breakdown, early response and steady state of the argon discharge. We characterize the plasma generation with respect to the input power, background gas pressure and gap size. It is found that the plasma discharge is generated mainly inside the gaps between the DR at positions that correspond to the antinodes of the resonant enhanced electric field pattern. The enhancement of the electric field inside the gaps is due to a combination of leaking and displacement current radiation from the DR. The plasma is sustained in over-critical densities due to the large skin depth with respect to the gap and plasma size. Electron densities are calculated in the order of {10}18{--}{10}19 {{{m}}}-3 for a gas pressure of 10 Torr, while they exceed 1020 {{{m}}}-3 in atmospheric conditions. Increase of input power leads to more intense ionization and thus faster plasma formation and results to a more symmetric plasma pattern. For low background gas pressure the discharge is diffusive and extends away from the gap region while in high pressure it is constricted inside the gap. An optimal gap size can be found to provide maximum EM energy transfer to the plasma. This fact demonstrates that the gap size dictates to a certain extent the resonant frequency and the Q-factor of the dielectric array and the breakdown fields can not be determined in a straight-forward way but they are functions of the resonators geometry and incident field frequency.

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.

PubMed

Nadir, Yona; Brenner, Benjamin; Fux, Liat; Shafat, Itay; Attias, Judith; Vlodavsky, Israel

2010-11-01

Heparanase is an endo-β-D-glucuronidase dominantly involved in tumor metastasis and angiogenesis. Recently, we demonstrated that heparanase is involved in the regulation of the hemostatic system. Our hypothesis was that heparanase is directly involved in activation of the coagulation cascade. Activated factor X and thrombin were studied using chromogenic assays, immunoblotting and thromboelastography. Heparanase levels were measured by enzyme-linked immunosorbent assay. A potential direct interaction between tissue factor and heparanase was studied by co-immunoprecipitation and far-western assays. Interestingly, addition of heparanase to tissue factor and activated factor VII resulted in a 3- to 4-fold increase in activation of the coagulation cascade as shown by increased activated factor X and thrombin production. Culture medium of human embryonic kidney 293 cells over-expressing heparanase and its derivatives increased activated factor X levels in a non-enzymatic manner. When heparanase was added to pooled normal plasma, a 7- to 8-fold increase in activated factor X level was observed. Subsequently, we searched for clinical data supporting this newly identified role of heparanase. Plasma samples from 35 patients with acute leukemia at presentation and 20 healthy donors were studied for heparanase and activated factor X levels. A strong positive correlation was found between plasma heparanase and activated factor X levels (r=0.735, P=0.001). Unfractionated heparin and an inhibitor of activated factor X abolished the effect of heparanase, while tissue factor pathway inhibitor and tissue factor pathway inhibitor-2 only attenuated the procoagulant effect. Using co-immunoprecipitation and far-western analyses it was shown that heparanase interacts directly with tissue factor. Overall, our results support the notion that heparanase is a potential modulator of blood hemostasis, and suggest a novel mechanism by which heparanase increases the generation of activated

Partitioning the variability of fasting plasma glucose levels in pedigrees. Genetic and environmental factors.

PubMed

Boehnke, M; Moll, P P; Kottke, B A; Weidman, W H

1987-04-01

Fasting plasma glucose measurements made in 1972-1977 on normoglycemic individuals in three-generation Caucasian pedigrees from Rochester, Minnesota were analyzed. The authors determined the contributions of polygenic loci and environmental factors to fasting plasma glucose variability in these pedigrees. To that end, fasting plasma glucose measurements were normalized by an inverse normal scores transformation and then regressed separately for males and females on measured concomitants including age, body mass index (weight/height2), season of measurement, sex hormone use, and diuretic use. The authors found that 27.7% of the variability in normalized fasting plasma glucose in these pedigrees is explained by these measured concomitants. Subsequent variance components analysis suggested that unmeasured polygenic loci and unmeasured shared environmental factors together account for at least an additional 36.7% of the variability in normalized fasting plasma glucose, with genes alone accounting for at least 27.3%. These results are consistent with the known familiality of diabetes, for which fasting plasma glucose level is an important predictor. Further, these familial factors provide an explanation for at least half the variability in normalized fasting plasma glucose which remains after regression on known concomitants.

Use of Plasma Actuators as a Moving-Wake Generator

NASA Technical Reports Server (NTRS)

Corke, Thomas C.; Thomas, Flint O.; Klapetzky Michael J.

2007-01-01

The work documented in this report tests the concept of using plasma actuators as a simple and easy way to generate a simulated moving-wake and the disturbances associated with it in turbines. This wake is caused by the blades of the upstream stages of the turbine. Two types of devices, one constructed of arrays of NACA 0018 airfoils, and the one constructed of flat plates were studied. The airfoils or plates were equipped with surface mounted dielectric barrier discharge (DBD) plasma actuators, which were used to generate flow disturbances resembling moving-wakes. CTA hot-wire anemometry and flow visualization using a smoke-wire were used to investigate the wake independence at various spacings and downstream locations. The flat plates were found to produce better results than the airfoils in creating large velocity fluctuations in the free-stream flow. Different dielectric materials, plasma actuator locations, leading edge contours, angles of attack and plate spacings were investigated, some with positive results. The magnitudes of the velocity fluctuations were found to be comparable to existing mechanical moving-wake generators, thus proving the feasibility of using plasma actuators as a moving-wake generator.

Studying the Generation Stage of a Plasma Jet in a Plasma Focus Discharge

NASA Astrophysics Data System (ADS)

Polukhin, S. N.; Gurei, A. E.; Nikulin, V. Ya.; Peregudova, E. N.; Silin, P. V.; Kharrasov, A. M.

2017-12-01

A dense compact plasmoid generated at the pinch collapse stage is revealed in a plasma focus discharge by laser optical methods. The initial size of the plasmoid is 1 mm, its electron density is more than 2 × 1019 cm-3, and the plasmoid propagates along the axis from the anode at an average velocity of more than 107 cm/s. A shock wave is generated in the residual argon plasma during the motion of the bunch, its density decreases to 1018 cm-3 at a distance of 3 cm from its place of generation, and the plasmoid expands by 3-5 times and almost merges together with the leading edge of the shock wave.

Effects of molecular size and chemical factor on plasma gene transfection

NASA Astrophysics Data System (ADS)

Ikeda, Yoshihisa; Motomura, Hideki; Kido, Yugo; Satoh, Susumu; Jinno, Masafumi

2016-07-01

In order to clarify the mechanism of plasma gene transfection, the relationship between transfection efficiency and transferred molecular size was investigated. Molecules with low molecular mass (less than 50 kDa; dye or dye-labeled oligonucleotide) and high molecular mass (more than 1 MDa; plasmid DNA or fragment of plasmid DNA) were transferred to L-929 cells. It was found that the transfection efficiency decreases with increasing in transferred molecular size and also depends on the tertiary structure of transferred molecules. Moreover, it was suggested the transfection mechanism is different between the molecules with low (less than 50 kDa) and high molecular mass (higher than 1 MDa). For the amount of gene transfection after plasma irradiation, which is comparable to that during plasma irradiation, it is shown that H2O2 molecules are the main contributor. The transfection efficiency decreased to 0.40 ± 0.22 upon scavenging the H2O2 generated by plasma irradiation using the catalase. On the other hand, when the H2O2 solution is dropped into the cell suspension without plasma irradiation, the transfection efficiency is almost 0%. In these results, it is also suggested that there is a synergetic effect of H2O2 with electrical factors or other reactive species generated by plasma irradiation.

Explosively Generated Plasmas: Measurement and Models of Shock Generation and Material Interactions

NASA Astrophysics Data System (ADS)

Emery, Samuel; Elert, Mark; Giannuzzi, Paul; Le, Ryan; McCarthy, Daniel; Schweigert, Igor

2017-06-01

Explosively generated plasmas (EGPs) are created by the focusing of a shock produced from an explosive driver via a conical waveguide. In the waveguide, the gases from the explosive along with the trapped air are accelerated and compressed (via Mach stemming) to such extent that plasma is produced. These EGPs have been measured in controlled experiments to achieve temperatures on the order of 1 eV and velocities as high as 25 km/s. We have conducted a combined modeling and measurement effort to increase the understanding for design purposes of the shock generation of EGPs and the interaction of EGP with explosive materials. Such efforts have led to improved measures of pressure and temperature, spatial structure of the plasma, and the decomposition/deflagration behavior of RDX upon exposure to an EGP. Funding provided by the Environmental Security Technology Certification Program (ESTCP) Munitions Response program area.

Non-Equilibrium Plasma MHD Electrical Power Generation at Tokyo Tech

NASA Astrophysics Data System (ADS)

Murakami, T.; Okuno, Y.; Yamasaki, H.

2008-02-01

This paper reviews the recent activities on radio-frequency (rf) electromagnetic-field-assisted magnetohydrodynamic (MHD) power generation experiments at the Tokyo Institute of Technology. An inductively coupled rf field (13.56 MHz) is continuously supplied to the disk-shaped Hall-type MHD generator. The first part of this paper describes a method of obtaining increased power output from a pure Argon plasma MHD power generator by incorporating an rf power source to preionize and heat the plasma. The rf heating enhances ionization of the Argon and raises the temperature of the free electron population above the nominally low 4500 K temperatures obtained without rf heating. This in turn enhances the plasma conductivity making MHD power generation feasible. We demonstrate an enhanced power output when rf heating is on approximately 5 times larger than the input power of the rf generator. The second part of this paper is a demonstration of a physical phenomenon of the rf-stabilization of the ionization instability, that had been conjectured for some time, but had not been seen experimentally. The rf heating suppresses the ionization instability in the plasma behavior and homogenizes the nonuniformity of the plasma structures. The power-generating performance is significantly improved with the aid of the rf power under wide seeding conditions. The increment of the enthalpy extraction ratio of around 2% is significantly greater than the fraction of the net rf power, that is, 0.16%, to the thermal input.

Peculiarities of Efficient Plasma Generation in Air and Water by Short Duration Laser Pulses

NASA Technical Reports Server (NTRS)

Adamovsky, Grigory; Floyd, Bertram M.

2017-01-01

We have conducted experiments to demonstrate an efficient generation of plasma discharges by focused nanosecond pulsed laser beams in air and provided recommendations on the design of optical systems to implement such plasma generation. We have also demonstrated generation of the secondary plasma discharge using the unused energy from the primary one. Focused nanosecond pulsed laser beams have also been utilized to generate plasma in water where we observed self-focusing and filamentation. Furthermore, we applied the laser generated plasma to the decomposition of methylene blue dye diluted in water.

Generation of low-temperature air plasma for food processing

NASA Astrophysics Data System (ADS)

Stepanova, Olga; Demidova, Maria; Astafiev, Alexander; Pinchuk, Mikhail; Balkir, Pinar; Turantas, Fulya

2015-11-01

The project is aimed at developing a physical and technical foundation of generating plasma with low gas temperature at atmospheric pressure for food industry needs. As known, plasma has an antimicrobial effect on the numerous types of microorganisms, including those that cause food spoilage. In this work an original experimental setup has been developed for the treatment of different foods. It is based on initiating corona or dielectric-barrier discharge in a chamber filled with ambient air in combination with a certain helium admixture. The experimental setup provides various conditions of discharge generation (including discharge gap geometry, supply voltage, velocity of gas flow, content of helium admixture in air and working pressure) and allows for the measurement of the electrical discharge parameters. Some recommendations on choosing optimal conditions of discharge generation for experiments on plasma food processing are developed.

Characterization of pulsed atmospheric-pressure plasma streams (PAPS) generated by a plasma gun

NASA Astrophysics Data System (ADS)

Robert, E.; Sarron, V.; Riès, D.; Dozias, S.; Vandamme, M.; Pouvesle, J.-M.

2012-06-01

An experimental study of atmospheric-pressure rare gas plasma propagation in a high-aspect-ratio capillary is reported. The plasma is generated with a plasma gun device based on a dielectric barrier discharge (DBD) reactor powered by either nanosecond or microsecond rise-time high-voltage pulses at single-shot to multi-kHz frequencies. The influence of the voltage waveform, pulse polarity, pulse repetition rate and capillary material have been studied using nanosecond intensified charge-coupled device imaging and plasma-front velocity measurements. The evolution of the plasma appearance during its propagation and the study of the role of the different experimental parameters lead us to suggest a new denomination of pulsed atmospheric-pressure plasma streams to describe all the plasma features, including the previously so-called plasma bullet. The unique properties of such non-thermal plasma launching in capillaries, far from the primary DBD plasma, are associated with a fast ionization wave travelling with velocity in the 107-108 cm s-1 range. Voltage pulse tailoring is shown to allow for a significant improvement of such plasma delivery. Thus, the plasma gun device affords unique opportunities in biomedical endoscopic applications.

Generator of the low-temperature heterogeneous plasma flow

NASA Astrophysics Data System (ADS)

Yusupov, D. I.; Gadzhiev, M. Kh; Tyuftyaev, A. S.; Chinnov, V. F.; Sargsyan, M. A.

2018-01-01

A generator of low-temperature dc plasma with an expanding channel of an output electrode for gas-thermal spraying was designed and constructed. The delivery of the sprayed powder into the cathode and anode arc-binding zones or into the plasma jet below the anode binding was realized. The electrophysical characteristics of both the plasma torch and the heterogeneous plasma flow with Al2O3 powder are studied. It is shown that the current-voltage characteristic (CVC) of a plasma torch depends on the gas flow rate. If the flow rate varies from 1 to 3 g/s, the falling CVC becomes gradually increasing. The speed and temperature of the sprayed powder are determined.

Electron beam generation in the turbulent plasma of Z-pinch discharges

NASA Astrophysics Data System (ADS)

Vikhrev, Victor V.; Baronova, Elena O.

1997-05-01

Numerical modeling of the process of electron beam generation in z-pinch discharges are presented. The proposed model represents the electron beam generation under turbulent plasma conditions. Strong current distribution inhomogeneity in the plasma column has been accounted for the adequate generation process investigation. Electron beam is generated near the maximum of compression due to run away mechanism and it is not related with the current break effect.

Generation of filamentary structures by beam-plasma interaction

NASA Astrophysics Data System (ADS)

Wang, X. Y.; Lin, Y.

2006-05-01

The previous simulations by Wang and Lin [Phys. Plasmas. 10, 3528, (2003)] showed that filaments, frequently observed in space plasmas, can form via the interaction between an ion beam and a background plasma. In this study, the physical mechanism for the generation of the filaments is investigated by a two-dimensional hybrid simulation, in which a field-aligned ion beam with relative beam density nb=0.1 and beam velocity Vb=10VA is initiated in a uniform plasma. Right-hand nonresonant ion beam modes, consistent with the linear theory, are found to be dominant in the linear stage of the beam-plasma interaction. In the later nonlinear stage, the nonresonant modes decay and the resonant modes grow through a nonlinear wave coupling. The interaction among the resonant modes leads to the formation of filamentary structures, which are the field-aligned structures (k⊥B) of magnetic field B, density, and temperature in the final stage. The filaments are nonlinearly generated in a prey-predator fashion by the parallel and oblique resonant ion beam modes, which meanwhile evolve into two types of shear Alfvén modes, with one mainly propagating along the background field B0 and the other obliquely propagating. The filamentary structures are found to be phase standing in the plasma frame, but their amplitude oscillates with time. In the dominant filament mode, fluctuations in the background ion density, background ion temperature, and beam density are in phase with the fluctuations in B, whereas the significantly enhanced beam temperature is antiphase with B. It is found that the filaments are produced by the interaction of at least two ion beam modes with comparable amplitudes, not by only one single mode, thus their generation mechanism is different from other mechanisms such as the stimulated excitation by the decay of an Alfvén wave.

THE DYNAMICAL GENERATION OF CURRENT SHEETS IN ASTROPHYSICAL PLASMA TURBULENCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howes, Gregory G.

2016-08-20

Turbulence profoundly affects particle transport and plasma heating in many astrophysical plasma environments, from galaxy clusters to the solar corona and solar wind to Earth's magnetosphere. Both fluid and kinetic simulations of plasma turbulence ubiquitously generate coherent structures, in the form of current sheets, at small scales, and the locations of these current sheets appear to be associated with enhanced rates of dissipation of the turbulent energy. Therefore, illuminating the origin and nature of these current sheets is critical to identifying the dominant physical mechanisms of dissipation, a primary aim at the forefront of plasma turbulence research. Here, we presentmore » evidence from nonlinear gyrokinetic simulations that strong nonlinear interactions between counterpropagating Alfvén waves, or strong Alfvén wave collisions, are a natural mechanism for the generation of current sheets in plasma turbulence. Furthermore, we conceptually explain this current sheet development in terms of the nonlinear dynamics of Alfvén wave collisions, showing that these current sheets arise through constructive interference among the initial Alfvén waves and nonlinearly generated modes. The properties of current sheets generated by strong Alfvén wave collisions are compared to published observations of current sheets in the Earth's magnetosheath and the solar wind, and the nature of these current sheets leads to the expectation that Landau damping of the constituent Alfvén waves plays a dominant role in the damping of turbulently generated current sheets.« less

Waves generated in the plasma plume of helicon magnetic nozzle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Nagendra; Rao, Sathyanarayan; Ranganath, Praveen

2013-03-15

Experimental measurements have shown that the plasma plume created in a helicon plasma device contains a conical structure in the plasma density and a U-shaped double layer (US-DL) tightly confined near the throat where plasma begins to expand from the source. Recently reported two-dimensional particle-in-cell simulations verified these density and US-DL features of the plasma plume. Simulations also showed that the plasma in the plume develops non-thermal feature consisting of radial ion beams with large densities near the conical surface of the density structure. The plasma waves that are generated by the radial ion beams affecting the structure of themore » plasma plume are studied here. We find that most intense waves persist in the high-density regions of the conical density structure, where the transversely accelerated ions in the radial electric fields in the plume are reflected setting up counter-streaming. The waves generated are primarily ion Bernstein modes. The nonlinear evolution of the waves leads to magnetic field-aligned striations in the fields and the plasma near the conical surface of the density structure.« less

Magnetic Field Generation During the Collision of Narrow Plasma Clouds

NASA Astrophysics Data System (ADS)

Sakai, Jun-ichi; Kazimura, Yoshihiro; Haruki, Takayuki

1999-06-01

We investigate the dynamics of the collision of narrow plasma clouds,whose transverse dimension is on the order of the electron skin depth.A 2D3V (two dimensions in space and three dimensions in velocity space)particle-in-cell (PIC) collisionless relativistic code is used toshow the generation of a quasi-staticmagnetic field during the collision of narrow plasma clouds both inelectron-ion and electron-positron (pair) plasmas. The localizedstrong magnetic fluxes result in the generation of the charge separationwith complicated structures, which may be sources of electromagneticas well as Langmuir waves. We also present one applicationof this process, which occurs during coalescence of magnetic islandsin a current sheet of pair plasmas.

Exploration to generate atmospheric pressure glow discharge plasma in air

NASA Astrophysics Data System (ADS)

Wenzheng, LIU; Chuanlong, MA; Shuai, ZHAO; Xiaozhong, CHEN; Tahan, WANG; Luxiang, ZHAO; Zhiyi, LI; Jiangqi, NIU; Liying, ZHU; Maolin, CHAI

2018-03-01

Atmospheric pressure glow discharge (APGD) plasma in air has high application value. In this paper, the methods of generating APGD plasma in air are discussed, and the characteristics of dielectric barrier discharge (DBD) in non-uniform electric field are studied. It makes sure that APGD in air is formed by DBD in alternating current electric field with using the absorbing electron capacity of electret materials to provide initial electrons and to end the discharge progress. Through designing electric field to form two-dimensional space varying electric field and three-dimensional space varying electric field, the development of electron avalanches in air-gap is suppressed effectively and a large space of APGD plasma in air is generated. Further, through combining electrode structures, a large area of APGD plasma in air is generated. On the other hand, by using the method of increasing the density of initial electrons, millimeter-gap glow discharge in atmospheric pressure air is formed, and a maximum gap distance between electrodes is 8 mm. By using the APGD plasma surface treatment device composed of contact electrodes, the surface modification of high polymer materials such as aramid fiber and polyester are studied and good effect of modifications is obtained. The present paper provides references for the researchers of industrial applications of plasma.

Method for generating a highly reactive plasma for exhaust gas aftertreatment and enhanced catalyst reactivity

DOEpatents

Whealton, John H.; Hanson, Gregory R.; Storey, John M.; Raridon, Richard J.; Armfield, Jeffrey S.; Bigelow, Timothy S.; Graves, Ronald L.

2002-01-01

A method for non-thermal plasma aftertreatment of exhaust gases the method comprising the steps of providing short risetime, high frequency, high power bursts of low-duty factor microwaves sufficient to generate a plasma discharge and passing a gas to be treated through the discharge so as to cause dissociative reduction of the exhaust gases and enhanced catalyst reactivity through application of the pulsed microwave fields directly to the catalyst material sufficient to cause a polarizability catastrophe and enhanced heating of the metal crystallite particles of the catalyst, and in the presence or absence of the plasma. The invention also includes a reactor for aftertreatment of exhaust gases.

S-Duct Engine Inlet Flow Control Using SDBD Plasma Streamwise Vortex Generators

NASA Astrophysics Data System (ADS)

Kelley, Christopher; He, Chuan; Corke, Thomas

2009-11-01

The results of a numerical simulation and experiment characterizing the performance of plasma streamwise vortex generators in controlling separation and secondary flow within a serpentine, diffusing duct are presented. A no flow control case is first run to check agreement of location of separation, development of secondary flow, and total pressure recovery between the experiment and numerical results. Upon validation, passive vane-type vortex generators and plasma streamwise vortex generators are implemented to increase total pressure recovery and reduce flow distortion at the aerodynamic interface plane: the exit of the S-duct. Total pressure recovery is found experimentally with a pitot probe rake assembly at the aerodynamic interface plane. Stagnation pressure distortion descriptors are also presented to show the performance increase with plasma streamwise vortex generators in comparison to the baseline no flow control case. These performance parameters show that streamwise plasma vortex generators are an effective alternative to vane-type vortex generators in total pressure recovery and total pressure distortion reduction in S-duct inlets.

Factor V Has Anticoagulant Activity in Plasma in the Presence of TFPIα: Difference between FV1 and FV2.

PubMed

van Doorn, Peter; Rosing, Jan; Duckers, Connie; Hackeng, Tilman M; Simioni, Paolo; Castoldi, Elisabetta

2018-06-04

 Activated factor V (FVa) is a potent procoagulant cofactor in the prothrombinase complex, whereas its precursor factor V (FV) stimulates the inhibition of factor Xa (FXa) by tissue factor pathway inhibitor-α (TFPIα), presumably by promoting TFPIα binding to phospholipids. Plasma FV comprises two glycosylation isoforms (FV1 and FV2) with low and high phospholipid-binding affinity, respectively. The FV1/FV2 ratio is increased in carriers of the FV R2 haplotype.  This article demonstrates the TFPIα-cofactor function of FV in plasma and compares FV1 and FV2.  Thrombin generation at low TF concentration was measured in FV-depleted plasma reconstituted with 0 to 100% FV, FV1 or FV2, and in 122 individuals genotyped for the R2 haplotype. The TFPIα-cofactor activities of FV1 and FV2 were also investigated in a model system of TFPIα-mediated FXa inhibition.  In the FV titration, thrombin generation first increased (up to 5% FV) and then progressively decreased at higher FV concentrations. This anticoagulant effect of FV, which was also observed with FV2 but not with FV1, was largely abolished by anti-TFPIα antibodies, suggesting that it reflects TFPIα-cofactor activity of FV. In the model system of TFPIα-mediated FXa inhibition, FV2 was a more potent TFPIα-cofactor than FV1, in line with their respective phospholipid affinities. Accordingly, FV R2 carriers had higher thrombin generation than non-carriers, even after correction for demographics and plasma levels of coagulation factors and inhibitors.  FV (and particularly its FV2 isoform) contributes to the TFPIα-dependent down-regulation of thrombin generation in plasma triggered with low TF. Schattauer GmbH Stuttgart.

Comparative biochemical studies of fresh frozen plasma and pooled solvent/detergent-treated plasma (octaplasLG® ) with focus on protein S and its impact in different thrombin generation assay set-ups.

PubMed

Heger, A; Janisch, S; Pock, K; Römisch, J

2016-10-01

The solvent/detergent treatment enables effective and robust inactivation of all lipid-enveloped viruses, but also inactivates partly sensitive plasma proteins such as protein S. The aim of this study was to investigate the thrombin generation capacity of octaplasLG ® , in particular focusing on the function of protein S in thrombin generation assay and the impact of assay settings. Sixteen octaplasLG ® batches and 32 units of single donor fresh frozen plasma (FFP) were investigated. For protein S, both functional activity and free antigen levels were measured. Thrombin generation assay was performed using two fluorogenic tests with different triggers. Finally, rotational thromboelastometry was performed. Mean protein S levels were lower in octaplasLG ® , but a wider range of values was found for FFP. Clotting parameters and thrombin generation capacities overlapped between the two plasma groups as demonstrated using both thrombin generation assays and different triggers. Spiking studies with protein S-depleted plasma, human purified protein S or antibodies against protein S confirmed a correlation between protein S and thrombin generation capacity under specific assay conditions, especially in an assay with low tissue factor concentration. Correlation between protein S and thrombin generation capacity was demonstrated in the TGA. Due to higher variability in protein S content in the FFP group, overlapping haemostatic potentials of the two plasma groups were found. © 2016 International Society of Blood Transfusion.

A study of single and binary ion plasma expansion into laboratory-generated plasma wakes

NASA Technical Reports Server (NTRS)

Wright, Kenneth Herbert, Jr.

1988-01-01

Plasma expansion into the wake of a large rectangular plate immersed in a collisionless, supersonic plasma was investigated in laboratory experiments. The experimental conditions address both single ion and binary ion plasma flows for the case of a body whose size is large in comparison with the Debye length, when the potential difference between the body and the plasma is relatively small. A new plasma source was developed to generate equi-velocity, binary ion plasma flows, which allows access to new parameter space that have previously been unavailable for laboratory studies. Specifically, the new parameters are the ionic mass ratio and the ionic component density ratio. In a series of experiments, a krypton-neon plasma is employed where the ambient density ratio of neon to krypton is varied more than an order of magnitude. The expansion in both the single ion and binary ion plasma cases is limited to early times, i.e., a few ion plasma periods, by the combination of plasma density, plasma drift speed, and vacuum chamber size, which prevented detailed comparison with self-similar theory.

About plasma points' generation in Z-pinch

NASA Astrophysics Data System (ADS)

Afonin, V. I.; Potapov, A. V.; Lazarchuk, V. P.; Murugov, V. M.; Senik, A. V.

1997-05-01

The streak tube study results (at visible and x-ray ranges) of dynamics of fast Z-pinch formed at explosion of metal wire in diode of high current generator are presented. Amplitude of current in the load reached ˜180 kA at increase time ˜50 ns. The results' analysis points to capability of controlling hot plasma points generation process in Z-pinch.

Chemically reactive species in liquids generated by atmospheric-pressure plasmas and their roles in plasma medicine

NASA Astrophysics Data System (ADS)

Hamaguchi, Satoshi

2013-07-01

Plasmas whose gas temperatures are close to room temperature may be generated in ambient air or a gas at atmospheric pressure with the use of low-frequency high voltage or low-power radio-frequency (RF) or microwave power applied to electrodes. Such plasmas can serve as a powerful source of free radicals and/or chemically reactive species that arise from atoms and molecules of the ambient gas. Recently use of such plasmas for medical purposes has attracted much attention as they can be implemented in possible medical devices that can cause blood coagulation, heal wounds, facilitate angiogenesis, sterilize surgical devices as well as living tissues without harming healthy cells, and selectively inactivate cancer cells. Especially of interest among reactive species generated by atmospheric-pressure plasmas (APP) are reactive oxygen species (ROS) and reactive nitrogen species (RNS) that are generated in liquid phase. Since most living tissues and cells are immersed in liquids (such as blood or culture media), reactive species generated by APPs in the gas phase are transported to the liquid phase and possibly converted to different types of reactive species therein before causing some influence on the tissues or cells. In this study, the rate equations are solved to evaluate concentrations of various reactive species in pure water that are originated by plasma reactions in atmosphere and possible effects of such species (including ROS/RNS) on living tissues and cells are discussed.

Defect generation in electronic devices under plasma exposure: Plasma-induced damage

NASA Astrophysics Data System (ADS)

Eriguchi, Koji

2017-06-01

The increasing demand for higher performance of ULSI circuits requires aggressive shrinkage of device feature sizes in accordance with Moore’s law. Plasma processing plays an important role in achieving fine patterns with anisotropic features in metal-oxide-semiconductor field-effect transistors (MOSFETs). This article comprehensively addresses the negative aspect of plasma processing — plasma-induced damage (PID). PID naturally not only modifies the surface morphology of materials but also degrades the performance and reliability of MOSFETs as a result of defect generation in the materials. Three key mechanisms of PID, i.e., physical, electrical, and photon-irradiation interactions, are overviewed in terms of modeling, characterization techniques, and experimental evidence reported so far. In addition, some of the emerging topics — control of parameter variability in ULSI circuits caused by PID and recovery of PID — are discussed as future perspectives.

Study of Plasma Motor Generator (PMG) tether system for orbit reboost

NASA Technical Reports Server (NTRS)

1987-01-01

Detailed designs were produced for a 2 kW plasma motor generator tether system based largely on existing hardware and hardware designs. Specifically, the hollow cathode design and electronics are derived from ion propulsion equipment. A prototype tether was constructed and will be tested for deployment, strength, resistance to breakage and abrasion and electrical properties. In addition, laboratory development models of the electronics will be used to operate two plasma motor generator hollow cathode assemblies with this tether to verify electrical performance parameters for the complete system. Results show that a low cost demonstration of a plasma motor generator tether system appears to be feasible by the middle of the 1990s.

Shock Generation and Control Using DBD Plasma Actuators

NASA Technical Reports Server (NTRS)

Patel, Mehul P.; Cain, Alan B.; Nelson, Christopher C.; Corke, Thomas C.; Matlis, Eric H.

2012-01-01

This report is the final report of a NASA Phase I SBIR contract, with some revisions to remove company proprietary data. The Shock Boundary Layer Interaction (SBLI) phenomena in a supersonic inlet involve mutual interaction of oblique shocks with boundary layers, forcing the boundary layer to separate from the inlet wall. To improve the inlet efficiency, it is desired to prevent or delay shock-induced boundary layer separation. In this effort, Innovative Technology Applications Company (ITAC), LLC and the University of Notre Dame (UND) jointly investigated the use of dielectric-barrier-discharge (DBD) plasma actuators for control of SBLI in a supersonic inlet. The research investigated the potential for DBD plasma actuators to suppress flow separation caused by a shock in a turbulent boundary layer. The research involved both numerical and experimental investigations of plasma flow control for a few different SBLI configurations: (a) a 12 wedge flow test case at Mach 1.5 (numerical and experimental), (b) an impinging shock test case at Mach 1.5 using an airfoil as a shock generator (numerical and experimental), and (c) a Mach 2.0 nozzle flow case in a simulated 15 X 15 cm wind tunnel with a shock generator (numerical). Numerical studies were performed for all three test cases to examine the feasibility of plasma flow control concepts. These results were used to guide the wind tunnel experiments conducted on the Mach 1.5 12 degree wedge flow (case a) and the Mach 1.5 impinging shock test case (case b) which were at similar flow conditions as the corresponding numerical studies to obtain experimental evidence of plasma control effects for SBLI control. The experiments also generated data that were used in validating the numerical studies for the baseline cases (without plasma actuators). The experiments were conducted in a Mach 1.5 test section in the University of Notre Dame Hessert Laboratory. The simulation results from cases a and b indicated that multiple

A research program in magnetogasdynamics utilizing hypervelocity coaxial plasma generators

NASA Technical Reports Server (NTRS)

Spight, C.

1976-01-01

A broadly-gauged research program in magnetogasdynamics utilizing hypervelocity coaxial plasma generators is presented. A complete hypervelocity coaxial plasma generator facility was assembled and tested. Significant progress was made in the direction of understanding the important processes in the interaction of hypervelocity MGD flow with transverse applied fields. It is now proposed to utilize the accumulated experimental capability and theoretical analysis in application to the analysis and design parameterization of pulsed magnetogasdynamic direct energy convertor configurations.

Development of a microplate coagulation assay for Factor V in human plasma.

PubMed

Tilley, Derek; Levit, Irina; Samis, John A

2011-06-28

Factor V (FV) in its activated form, FVa, is a critical regulator of thrombin generation during fibrin clot formation. There is a need of a simple, fast, and inexpensive microplate-based coagulation assay to measure the functional activity of FV in human plasma. The objective of this study was to develop a microplate-based assay that measures FV coagulation activity during clot formation in human plasma, which is currently not available. The FV assay requires a kinetic microplate reader to measure the change in absorbance at 405nm during fibrin formation in human plasma. The FV assay accurately measures the time, initial rate, and extent of fibrin clot formation in human plasma. The FV microplate assay is simple, fast, economical, sensitive to approx 24-80pM, and multiple samples may be analyzed simultaneously. All the required materials are commercially available. Standard curves of time or initial rate of fibrin clot formation vs FV activity in the 1-stage assay (Without activation by thrombin) may be used to measure FV activity in samples of human plasma. The assay was used to demonstrate that in nine patients with disseminated intravascular coagulation (DIC), the FV 1-stage, 2-stage (With activation by thrombin), and total (2-stage activity - 1-stage activity) activities were decreased, on average, by approximately 54%, 44%, and 42%, respectively, from prolonged clot times when compared to normal pooled human reference plasma (NHP). The results indicate that the FV in the DIC patient plasmas supported both a delayed and slower rate of fibrin clot formation compared with NHP; however, the extent of fibrin clot formation in the DIC patients remained largely unchanged from that observed with NHP. The FV microplate assay may be easily adapted to measure the activity of any coagulation factor using the appropriate factor-deficient plasma and clot initiating reagent. The microplate assay will find use in both research and clinical laboratories to provide measurement

Development of a microplate coagulation assay for Factor V in human plasma

PubMed Central

2011-01-01

Background Factor V (FV) in its activated form, FVa, is a critical regulator of thrombin generation during fibrin clot formation. There is a need of a simple, fast, and inexpensive microplate-based coagulation assay to measure the functional activity of FV in human plasma. The objective of this study was to develop a microplate-based assay that measures FV coagulation activity during clot formation in human plasma, which is currently not available. Methods The FV assay requires a kinetic microplate reader to measure the change in absorbance at 405nm during fibrin formation in human plasma. The FV assay accurately measures the time, initial rate, and extent of fibrin clot formation in human plasma. Results The FV microplate assay is simple, fast, economical, sensitive to approx 24-80pM, and multiple samples may be analyzed simultaneously. All the required materials are commercially available. Standard curves of time or initial rate of fibrin clot formation vs FV activity in the 1-stage assay (Without activation by thrombin) may be used to measure FV activity in samples of human plasma. The assay was used to demonstrate that in nine patients with disseminated intravascular coagulation (DIC), the FV 1-stage, 2-stage (With activation by thrombin), and total (2-stage activity - 1-stage activity) activities were decreased, on average, by approximately 54%, 44%, and 42%, respectively, from prolonged clot times when compared to normal pooled human reference plasma (NHP). The results indicate that the FV in the DIC patient plasmas supported both a delayed and slower rate of fibrin clot formation compared with NHP; however, the extent of fibrin clot formation in the DIC patients remained largely unchanged from that observed with NHP. Conclusions The FV microplate assay may be easily adapted to measure the activity of any coagulation factor using the appropriate factor-deficient plasma and clot initiating reagent. The microplate assay will find use in both research and

Effects of current on droplet generation and arc plasma in gas metal arc welding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, J.; Tsai, H. L.

2006-09-01

In gas metal arc welding (GMAW), a technology using pulsed currents has been employed to achieve the one-droplet-per-pulse (ODPP) metal transfer mode with the advantages of low average currents, a stable and controllable droplet generation, and reduced spatter. In this paper, a comprehensive model was developed to study the effects of different current profiles on the droplet formation, plasma generation, metal transfer, and weld pool dynamics in GMAW. Five types of welding currents were studied, including two constant currents and three wave form currents. In each type, the transient temperature and velocity distributions of the arc plasma and the moltenmore » metal, and the shapes of the droplet and the weld pool were calculated. The results showed that a higher current generates smaller droplets, higher droplet frequency, and higher electromagnetic force that becomes the dominant factor detaching the droplet from the electrode tip. The model has demonstrated that a stable ODPP metal transfer mode can be achieved by choosing a current with proper wave form for given welding conditions.« less

Reactive species in non-equilibrium atmospheric-pressure plasmas: Generation, transport, and biological effects

NASA Astrophysics Data System (ADS)

Lu, X.; Naidis, G. V.; Laroussi, M.; Reuter, S.; Graves, D. B.; Ostrikov, K.

2016-05-01

Non-equilibrium atmospheric-pressure plasmas have recently become a topical area of research owing to their diverse applications in health care and medicine, environmental remediation and pollution control, materials processing, electrochemistry, nanotechnology and other fields. This review focuses on the reactive electrons and ionic, atomic, molecular, and radical species that are produced in these plasmas and then transported from the point of generation to the point of interaction with the material, medium, living cells or tissues being processed. The most important mechanisms of generation and transport of the key species in the plasmas of atmospheric-pressure plasma jets and other non-equilibrium atmospheric-pressure plasmas are introduced and examined from the viewpoint of their applications in plasma hygiene and medicine and other relevant fields. Sophisticated high-precision, time-resolved plasma diagnostics approaches and techniques are presented and their applications to monitor the reactive species and plasma dynamics in the plasma jets and other discharges, both in the gas phase and during the plasma interaction with liquid media, are critically reviewed. The large amount of experimental data is supported by the theoretical models of reactive species generation and transport in the plasmas, surrounding gaseous environments, and plasma interaction with liquid media. These models are presented and their limitations are discussed. Special attention is paid to biological effects of the plasma-generated reactive oxygen and nitrogen (and some other) species in basic biological processes such as cell metabolism, proliferation, survival, etc. as well as plasma applications in bacterial inactivation, wound healing, cancer treatment and some others. Challenges and opportunities for theoretical and experimental research are discussed and the authors' vision for the emerging convergence trends across several disciplines and application domains is presented to

Material for electrodes of low temperature plasma generators

DOEpatents

Caplan, Malcolm; Vinogradov, Sergel Evge'evich; Ribin, Valeri Vasil'evich; Shekalov, Valentin Ivanovich; Rutberg, Philip Grigor'evich; Safronov, Alexi Anatol'evich

2008-12-09

Material for electrodes of low temperature plasma generators. The material contains a porous metal matrix impregnated with a material emitting electrons. The material uses a mixture of copper and iron powders as a porous metal matrix and a Group IIIB metal component such as Y.sub.2O.sub.3 is used as a material emitting electrons at, for example, the proportion of the components, mass %: iron: 3-30; Y.sub.2O.sub.3:0.05-1; copper: the remainder. Copper provides a high level of heat conduction and electric conductance, iron decreases intensity of copper evaporation in the process of plasma creation providing increased strength and lifetime, Y.sub.2O.sub.3 provides decreasing of electronic work function and stability of arc burning. The material can be used for producing the electrodes of low temperature AC plasma generators used for destruction of liquid organic wastes, medical wastes, and municipal wastes as well as for decontamination of low level radioactive waste, the destruction of chemical weapons, warfare toxic agents, etc.

Material for electrodes of low temperature plasma generators

DOEpatents

Caplan, Malcolm; Vinogradov, Sergel Evge'evich; Ribin, Valeri Vasil'evich; Shekalov, Valentin Ivanovich; Rutberg, Philip Grigor'evich; Safronov, Alexi Anatol'evich; Shiryaev, Vasili Nikolaevich

2010-03-02

Material for electrodes of low temperature plasma generators. The material contains a porous metal matrix impregnated with a material emitting electrons. The material uses a mixture of copper and iron powders as a porous metal matrix and a Group IIIB metal component such as Y.sub.2O.sub.3 is used as a material emitting electrons at, for example, the proportion of the components, mass %: iron:3-30; Y.sub.2O.sub.3:0.05-1; copper: the remainder. Copper provides a high level of heat conduction and electric conductance, iron decreases intensity of copper evaporation in the process of plasma creation providing increased strength and lifetime, Y.sub.2O.sub.3 provides decreasing of electronic work function and stability of arc burning. The material can be used for producing the electrodes of low temperature AC plasma generators used for destruction of liquid organic wastes, medical wastes, municipal wastes as well as for decontamination of low level radioactive waste, the destruction of chemical weapons, warfare toxic agents, etc.

Current Interruption and Particle Beam Generation by a Plasma Focus.

DTIC Science & Technology

1982-11-30

Through collaboration with Dr. K. H. Schoenbach of Texas Tech University the plasma focus opening switch (PFOS) was revised to answer basic questions...results are consistent with the snowplow model. The final analysis of the plasma focus particle beam generation experiments was completed and a...strong correlation was found for the beam-target model as the mechanism for neutron production in the Illinois plasma focus device. (Author)

Nonlinear currents generated in plasma by a radiation pulse with a frequency exceeding the electron plasma frequency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grishkov, V. E.; Uryupin, S. A., E-mail: uryupin@sci.lebedev.ru

2016-09-15

It is shown that the nonlinear currents generated in plasma by a radiation pulse with a frequency exceeding the electron plasma frequency change substantially due to a reduction in the effective electron–ion collision frequency.

Preliminary characterization of a laser-generated plasma sheet

DOE PAGES

Keiter, P. A.; Malamud, G.; Trantham, M.; ...

2014-12-10

We present the results from recent experiments to create a flowing plasma sheet. Two groups of three laser beams with nominally 1.5 kJ of energy per group were focused to separate pointing locations, driving a shock into a wedge target. As the shock breaks out of the wedge, the plasma is focused on center, creating a sheet of plasma. Measurements at 60 ns indicate the plasma sheet has propagated 2825 microns with an average velocity of 49 microns/ns. These experiments follow previous experiments, which are aimed at studying similar physics as that found in the hot spot region of cataclysmicmore » variables. Krauland et al created a flowing plasma, which represents the flowing plasma from the secondary star. This flow interacted with a stationary object, which represented the disk around the white dwarf. A reverse shock is a shock formed when a freely expanding plasma encounters an obstacle. Reverse shocks can be generated by a blast wave propagating through a medium. As a result, they can also be found in binary star systems where the flowing gas from a companion star interacts with the accretion disk of the primary star.« less

Simulations of controlled spectral emission of Al plasmas generated by temporally tailored laser irradiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colombier, J. P.; Guillermin, M.; Garrelie, F.

2010-10-08

Hydrodynamics simulations and irradiation experiments were performed to correlate ul-trashort intensity envelopes of the laser fields and thermodynamical states reached by the emerging plasma phase in ablation regimes. We discuss the efficiency of energy coupling as a function of different intensity envelopes and the resulting temperature, density and ionization states since the energy delivery rate is an essential factor that predetermines the material thermodynamic evolution. Subsequently, we examine the plasma composition in calculating the proportion of neutral/ion species typical of LIBS signals and comparing it with neutral/ion ratios given by experimental results. Moreover, the calculations allow to investigate the efficiencymore » of nanoparticles generation from materials subjected to different heating rates. These can be related to hydrodynamic ejection of nanosized liquid layers upon the action of mechanic waves. With support from numerical simulations of the hydrodynamic advance of the excited matter, experiments revealed that mastering intensity envelopes of ultrashort laser pulse leads to further control on the ablation products. Emerging plasma phase in a hot state generates specific spectral emission patterns that can serve as indicators for its controlled formation and kinetic evolution.« less

Magnetic Field Generation Processes Involving Gravity and Differential Rotation. Solitary Plasma Rings Formation around Black Holes

NASA Astrophysics Data System (ADS)

Coppi, Bruno

2012-10-01

A clear theoretical framework to describe how magnetic fields are generated and amplified is provided by the magneto-gravitational modes that involve both differential rotation and gravity and for which other factors such as temperature gradients can contribute to their excitation. These modes are shown to be important for the evolution of plasma disks surrounding black holes.footnotetextB. Coppi, Phys. Plasmas 18, 032901 (2011) Non-linear and axi-symmetric plasmas and associated field configurations are found under stationary conditions that do not involve the presence of a pre-existing ``seed'' magnetic field unlike other configurations found previously.footnotetextIbid. The relevant magnetic energy density is of the order of the gravitationally confined plasma pressure. The solitary plasma rings that characterize these configurations are localized radially over regions with vanishing differential rotation and can be envisioned as the saturated state of magneto-gravitational modes. The ``source'' of these configurations is the combination of the gravitational force and of the plasma density gradient orthogonal to it.

Nitrogen Gas Plasma Generated by a Static Induction Thyristor as a Pulsed Power Supply Inactivates Adenovirus

PubMed Central

Sakudo, Akikazu; Toyokawa, Yoichi; Imanishi, Yuichiro

2016-01-01

Adenovirus is one of the most important causative agents of iatrogenic infections derived from contaminated medical devices or finger contact. In this study, we investigated whether nitrogen gas plasma, generated by applying a short high-voltage pulse to nitrogen using a static induction thyristor power supply (1.5 kilo pulse per second), exhibited a virucidal effect against adenoviruses. Viral titer was reduced by one log within 0.94 min. Results from detection of viral capsid proteins, hexon and penton, by Western blotting and immunochromatography were unaffected by the plasma treatment. In contrast, analysis using the polymerase chain reaction suggested that plasma treatment damages the viral genomic DNA. Reactive chemical products (hydrogen peroxide, nitrate, and nitrite), ultraviolet light (UV-A) and slight temperature elevations were observed during the operation of the gas plasma device. Viral titer versus intensity of each potential virucidal factor were used to identify the primary mechanism of disinfection of adenovirus. Although exposure to equivalent levels of UV-A or heat treatment did not inactivate adenovirus, treatment with a relatively low concentration of hydrogen peroxide efficiently inactivated the virus. Our results suggest the nitrogen gas plasma generates reactive chemical products that inactivate adenovirus by damaging the viral genomic DNA. PMID:27322066

Generation of nano roughness on fibrous materials by atmospheric plasma

NASA Astrophysics Data System (ADS)

Kulyk, I.; Scapinello, M.; Stefan, M.

2012-12-01

Atmospheric plasma technology finds novel applications in textile industry. It eliminates the usage of water and of hazard liquid chemicals, making production much more eco-friendly and economically convenient. Due to chemical effects of atmospheric plasma, it permits to optimize dyeing and laminating affinity of fabrics, as well as anti-microbial treatments. Other important applications such as increase of mechanical resistance of fiber sleeves and of yarns, anti-pilling properties of fabrics and anti-shrinking property of wool fabrics were studied in this work. These results could be attributed to the generation of nano roughness on fibers surface by atmospheric plasma. Nano roughness generation is extensively studied at different conditions. Alternative explanations for the important practical results on textile materials and discussed.

Pulsed Energy Systems for Generating Plasmas

NASA Technical Reports Server (NTRS)

Rose, M. Franklin; Shotts, Z.

2005-01-01

This paper will describe the techniques needed to electrically generate highly ionized dense plasmas for a variety of applications. The components needed in pulsed circuits are described in terms of general performance parameters currently available from commercial vendors. Examples of pulsed systems using these components are described and technical data from laboratory experiments presented. Experimental data are given for point designs, capable of multi-megawatt power levels.

Control of ultra-intense single attosecond pulse generation in laser-driven overdense plasmas.

PubMed

Liu, Qingcao; Xu, Yanxia; Qi, Xin; Zhao, Xiaoying; Ji, Liangliang; Yu, Tongpu; Wei, Luo; Yang, Lei; Hu, Bitao

2013-12-30

Ultra-intense single attosecond pulse (AP) can be obtained from circularly polarized (CP) laser interacting with overdense plasma. High harmonics are naturally generated in the reflected laser pulses due to the laser-induced one-time drastic oscillation of the plasma boundary. Using two-dimensional (2D) planar particle-in-cell (PIC) simulations and analytical model, we show that multi-dimensional effects have great influence on the generation of AP. Self-focusing and defocusing phenomena occur in front of the compressed plasma boundary, which lead to the dispersion of the generated AP in the far field. We propose to control the reflected high harmonics by employing a density-modulated foil target (DMFT). When the target density distribution fits the laser intensity profile, the intensity of the attosecond pulse generated from the center part of the plasma has a flatten profile within the center range in the transverse direction. It is shown that a single 300 attosecond (1 as = 10(-18)s) pulse with the intensity of 1.4 × 10(21) W cm(-2) can be naturally generated. Further simulations reveal that the reflected high harmonics properties are highly related to the modulated density distribution and the phase offset between laser field and the carrier envelope. The emission direction of the AP generated from the plasma boundary can be controlled in a very wide range in front of the plasma surface by combining the DMFT and a suitable driving laser.

Short-range wakefields generated in the blowout regime of plasma-wakefield acceleration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stupakov, G.

In the past, calculation of wakefields generated by an electron bunch propagating in a plasma has been carried out in linear approximation, where the plasma perturbation can be assumed small and plasma equations of motion linearized. This approximation breaks down in the blowout regime where a high-density electron driver expels plasma electrons from its path and creates a cavity void of electrons in its wake. Here in this paper, we develop a technique that allows us to calculate short-range longitudinal and transverse wakes generated by a witness bunch being accelerated inside the cavity. Our results can be used for studiesmore » of the beam loading and the hosing instability of the witness bunch in plasma-wakefield and laser-wakefield acceleration.« less

Short-range wakefields generated in the blowout regime of plasma-wakefield acceleration

NASA Astrophysics Data System (ADS)

Stupakov, G.

2018-04-01

In the past, calculation of wakefields generated by an electron bunch propagating in a plasma has been carried out in linear approximation, where the plasma perturbation can be assumed small and plasma equations of motion linearized. This approximation breaks down in the blowout regime where a high-density electron driver expels plasma electrons from its path and creates a cavity void of electrons in its wake. In this paper, we develop a technique that allows us to calculate short-range longitudinal and transverse wakes generated by a witness bunch being accelerated inside the cavity. Our results can be used for studies of the beam loading and the hosing instability of the witness bunch in plasma-wakefield and laser-wakefield acceleration.

Short-range wakefields generated in the blowout regime of plasma-wakefield acceleration

DOE PAGES

Stupakov, G.

2018-04-02

In the past, calculation of wakefields generated by an electron bunch propagating in a plasma has been carried out in linear approximation, where the plasma perturbation can be assumed small and plasma equations of motion linearized. This approximation breaks down in the blowout regime where a high-density electron driver expels plasma electrons from its path and creates a cavity void of electrons in its wake. Here in this paper, we develop a technique that allows us to calculate short-range longitudinal and transverse wakes generated by a witness bunch being accelerated inside the cavity. Our results can be used for studiesmore » of the beam loading and the hosing instability of the witness bunch in plasma-wakefield and laser-wakefield acceleration.« less

Contribution of photocurrent mechanism and influence of plasma length in THz generation by two-color laser induced plasma

NASA Astrophysics Data System (ADS)

Alirezaee, Hajar; Sharifian, Mehdi

2018-04-01

The contribution of the photocurrent mechanism has been investigated in terahertz (THz) generation in laser-induced gas plasma. This study was done through comparing the THz amplitude for two phase differences (" separators="| φ = 0 , π / 2 ) between the fundamental pulse and its second harmonic. Our particle-in-cell simulation result showed that this mechanism played the most important role in the two-color regime with a low-frequency range. We also investigated the effect of the plasma channel length on generated THz amplitude, and it was found that THz amplitude would depend significantly on the plasma channel length.

Charge-exchange plasma generated by an ion thruster

NASA Technical Reports Server (NTRS)

Kaufman, H. R.

1977-01-01

The charge exchange plasma generated by an ion thruster was investigated experimentally using both 5 cm and 15 cm thrusters. Results are shown for wide ranges of radial distance from the thruster and angle from the beam direction. Considerations of test environment, as well as distance from the thruster, indicate that a valid simulation of a thruster on a spacecraft was obtained. A calculation procedure and a sample calculation of charge exchange plasma density and saturation electron current density are included.

Investigation Of Plasma Critical Surface Rippling By Harmonics Generation In Laser Plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Racz, E.; Foeldes, I. B.; Szatmari, S.

2006-01-15

Experiments were carried out by a tightly focused, prepulse-free hybrid KrF excimer-dye laser system (700fs pulse duration, 248nm wavelength, 15mJ pulse energy). Intense 2{omega}, 3{omega} and near threshold 4{omega} were generated in laser plasmas on solid surfaces for p- and s-polarized 1.5{center_dot}1017 W/cm2 radiation intensity. Directionality and polarization properties were investigated depending on the laser intensity and polarization. The observations showed diffuse propagation of harmonics for intensities above 1016 W/cm2 and the polarization of harmonics was mixed for the highest intensities. The explanation of these results is surface rippling of the plasma critical surface because of the Rayleigh-Taylor instability, whichmore » is an intrinsic consequence of the unstable balance between light pressure and plasma expansion.« less

Generation and acceleration of neutral atoms in intense laser plasma experiments

NASA Astrophysics Data System (ADS)

Tata, Sheroy; Mondal, Angana; Sarkar, Shobhik; Ved, Yash; Lad, Amit D.; Pasley, John; Colgan, James; Krishnamurthy, M.

2017-10-01

The interaction of a high intensity (>=1018 W/cm2), high contrast (>=109), ultra-short (30fs) laser with solid targets generates a highly dense hot plasma. The quasi-static electric fields in such plasmas are well known for ion acceleration via the target normal sheath acceleration process. Under such conditions charge reduction to generate fast neutral atoms is almost inhibited. Improvised Thomson parabola spectrometry with improved signal to noise ratio has enabled us to measure the signals of fast neutral atoms and negative ions having energies in excess of tens of keV. A study on the neutralization of accelerated protons in plasma shows that the neutral atom to all particle ratio rises sharply from a few percent at the highest detectable energy to 50 % at 15 keV. Using usual charge transfer reactions the generation of neutral atoms can not be explained, thus we conjecture that the neutralization of the accelerated ions is not from the hot dense region of the plasma but neutral atom formation takes place by co-propagating ions with low energy electrons enhancing the effective neutral ratio.

Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

NASA Astrophysics Data System (ADS)

Jablonowski, H.; Bussiahn, R.; Hammer, M. U.; Weltmann, K.-D.; von Woedtke, Th.; Reuter, S.

2015-12-01

Plasma medicine utilizes the combined interaction of plasma produced reactive components. These are reactive atoms, molecules, ions, metastable species, and radiation. Here, ultraviolet (UV, 100-400 nm) and, in particular, vacuum ultraviolet (VUV, 10-200 nm) radiation generated by an atmospheric pressure argon plasma jet were investigated regarding plasma emission, absorption in a humidified atmosphere and in solutions relevant for plasma medicine. The energy absorption was obtained for simple solutions like distilled water (dH2O) or ultrapure water and sodium chloride (NaCl) solution as well as for more complex ones, for example, Rosewell Park Memorial Institute (RPMI 1640) cell culture media. As moderate stable reactive oxygen species, hydrogen peroxide (H2O2) was studied. Highly reactive oxygen radicals, namely, superoxide anion (O2•-) and hydroxyl radicals (•OH), were investigated by the use of electron paramagnetic resonance spectroscopy. All species amounts were detected for three different treatment cases: Plasma jet generated VUV and UV radiation, plasma jet generated UV radiation without VUV part, and complete plasma jet including all reactive components additionally to VUV and UV radiation. It was found that a considerable amount of radicals are generated by the plasma generated photoemission. From the experiments, estimation on the low hazard potential of plasma generated VUV radiation is discussed.

[Relations between plasma-erythrocyte viscosity factors and ESR].

PubMed

Cortinovis, A; Crippa, A; Crippa, M; Bosoni, T; Moratti, R

1992-09-01

The ESR is usually put in relationship: to the real density of the RBCs (erythrocytes) (difference between the RBC specific gravity and the plasma one), and to the resistance that the RBCs meet moving in a medium, which is due to the plasma viscosity and to the total external RBC surface. When the RBCs take shape of aggregates, their external surface is decreased and ESR increases. The most important plasma factor causing changes in ESR is the fibrinogen level followed by the plasma globulins and by the products arising from the tissue damage. The resistance that the RBCs meet moving in the plasma is well expressed by the measurement of the plasma-RBC viscosity considering that is inclusive of both factors that are the plasma viscosity and the external RBC surface. The plasma-RBC viscosity is the resultant of several factors: Fa = Fb - Fe - Fs - Fm, were: Fa is the resultant, Fb the attracting forces due to the proteic macromolecules, Fe the repulsing forces due the negative charges. Fs the repulsing forces due to the shear-stress, Fm the force which opposes itself against the surface tension of the aggregation; it depends on the RBC morphology and on the RBC rigidity. The ESR has been recently used like an index of the RBC aggregation. The Authors study the relationship between several hemorheological parameters and the ESR in infective and inflammatory processes.(ABSTRACT TRUNCATED AT 250 WORDS)

Terahertz generation by beating two Langmuir waves in a warm and collisional plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Xiao-Bo; Qiao, Xin; Cheng, Li-Hong

2015-09-15

Terahertz (THz) radiation generated by beating of two Langmuir waves in a warm and collisional plasma is discussed theoretically. The critical angle between the two Langmuir waves and the critical wave-length (wave vector) of Langmuir waves for generating THz radiation are obtained analytically. Furthermore, the maximum radiation energy is obtained. We find that the critical angle, the critical wave-length, and the generated radiation energy strongly depend on plasma temperature and wave-length of the Langmuir waves. That is, the THz radiation generated by beating of two Langmuir waves in a warm and collisional plasma can be controlled by adjusting the plasmamore » temperature and the Langmuir wave-length.« less

Low Cost, Efficient Microcavity Plasma Ozone Generation for Water Remediation and Air Purification

DTIC Science & Technology

2012-06-01

Eliasson, and M. Hirth, “ Ozone Generation from Oxygen and Air: Discharge Physics and Reaction Mechanisms,” Ozone Sci. and Eng., vol. 10, pp. 367-378...Phase I Final Report: Low Cost, Efficient Microcavity Plasma Ozone Generation for Water Remediation and Air Purification...Contract Number: FA9550-11-C-0087 June 2012 Low Cost, Efficient Microcavity Plasma Ozone Generation for Water Remediation

Electromagnetic radiation generated by arcing in low density plasma

NASA Technical Reports Server (NTRS)

Vayner, Boris V.; Ferguson, Dale C.; Snyder, David B.; Doreswamy, C. V.

1996-01-01

An unavoidable step in the process of space exploration is to use high-power, very large spacecraft launched into Earth orbit. Obviously, the spacecraft will need powerful energy sources. Previous experience has shown that electrical discharges occur on the surfaces of a high-voltage array, and these discharges (arcs) are undesirable in many respects. Moreover, any high voltage conductor will interact with the surrounding plasma, and that interaction may result in electrical discharges between the conductor and plasma (or between two conductors with different potentials, for example, during docking and extravehicular activity). One very important aspect is the generation of electromagnetic radiation by arcing. To prevent the negative influence of electromagnetic noise on the operation of spacecraft systems, it seems necessary to determine the spectra and absolute levels of the radiation, and to determine limitations on the solar array bias voltage that depend on the parameters of LEO plasma and the technical requirements of the spacecraft equipment. This report describes the results of an experimental study and computer simulation of the electromagnetic radiation generated by arcing on spacecraft surfaces. A large set of high quality data was obtained during the Solar Array Module Plasma Interaction Experiment (SAMPIE, flight STS-62) and ground test. These data include the amplitudes of current, pulse forms, duration of each arc, and spectra of plasma waves. A theoretical explanation of the observed features is presented in this report too. The elaborated model allows us to determine the parameters of the electromagnetic noise for different frequency ranges, distances from the arcing site, and distinct kinds of plasma waves.

Generation of high-field narrowband terahertz radiation by counterpropagating plasma wakefields

NASA Astrophysics Data System (ADS)

Timofeev, I. V.; Annenkov, V. V.; Volchok, E. P.

2017-10-01

It is found that nonlinear interaction of plasma wakefields driven by counterpropagating laser or particle beams can efficiently generate high-power electromagnetic radiation at the second harmonic of the plasma frequency. Using a simple analytical theory and particle-in-cell simulations, we show that this phenomenon can be attractive for producing high-field ( ˜10 MV/cm) tunable terahertz radiation with a narrow line width. For laser drivers produced by existing petawatt-class systems, this nonlinear process opens the way to the generation of gigawatt, multi-millijoule terahertz pulses which are not presently available for any other generating schemes.

Characterization of X-ray emission from laser generated plasma

NASA Astrophysics Data System (ADS)

Cannavò, Antonino; Torrisi, Lorenzo; Ceccio, Giovanni; Cutroneo, Mariapompea; Calcagno, Lucia; Sciuto, Antonella; Mazzillo, Massimo

2018-01-01

X-ray emission from laser generated plasma was studied at low (1010 W/cm2) and high (1018 W/cm2) intensity using ns and fs laser, respectively. Plasma characteristics were controlled trough the laser parameters, the irradiation conditions and the target properties. The X-ray spectra were acquired using fast detection technique based on SiC diodes with different active regions. The X-ray yield increases with the atomic number of the target, both at low and high intensity, and a similar empirical law has been obtained. The X-ray emission mechanisms from plasma are correlated to the plasma temperature and density and to the Coulomb charge particle acceleration, due to the charge separation effects produced in the non-equilibrium plasma. Functional dependences, theoretical approaches and interpretation of possible mechanism will be presented and discussed.

Effect of Dielectric and Liquid on Plasma Sterilization Using Dielectric Barrier Discharge Plasma

PubMed Central

Mastanaiah, Navya; Johnson, Judith A.; Roy, Subrata

2013-01-01

Plasma sterilization offers a faster, less toxic and versatile alternative to conventional sterilization methods. Using a relatively small, low temperature, atmospheric, dielectric barrier discharge surface plasma generator, we achieved ≥6 log reduction in concentration of vegetative bacterial and yeast cells within 4 minutes and ≥6 log reduction of Geobacillus stearothermophilus spores within 20 minutes. Plasma sterilization is influenced by a wide variety of factors. Two factors studied in this particular paper are the effect of using different dielectric substrates and the significance of the amount of liquid on the dielectric surface. Of the two dielectric substrates tested (FR4 and semi-ceramic (SC)), it is noted that the FR4 is more efficient in terms of time taken for complete inactivation. FR4 is more efficient at generating plasma as shown by the intensity of spectral peaks, amount of ozone generated, the power used and the speed of killing vegetative cells. The surface temperature during plasma generation is also higher in the case of FR4. An inoculated FR4 or SC device produces less ozone than the respective clean devices. Temperature studies show that the surface temperatures reached during plasma generation are in the range of 30°C–66°C (for FR4) and 20°C–49°C (for SC). Surface temperatures during plasma generation of inoculated devices are lower than the corresponding temperatures of clean devices. pH studies indicate a slight reduction in pH value due to plasma generation, which implies that while temperature and acidification may play a minor role in DBD plasma sterilization, the presence of the liquid on the dielectric surface hampers sterilization and as the liquid evaporates, sterilization improves. PMID:23951023

Effect of dielectric and liquid on plasma sterilization using dielectric barrier discharge plasma.

PubMed

Mastanaiah, Navya; Johnson, Judith A; Roy, Subrata

2013-01-01

Plasma sterilization offers a faster, less toxic and versatile alternative to conventional sterilization methods. Using a relatively small, low temperature, atmospheric, dielectric barrier discharge surface plasma generator, we achieved ≥ 6 log reduction in concentration of vegetative bacterial and yeast cells within 4 minutes and ≥ 6 log reduction of Geobacillus stearothermophilus spores within 20 minutes. Plasma sterilization is influenced by a wide variety of factors. Two factors studied in this particular paper are the effect of using different dielectric substrates and the significance of the amount of liquid on the dielectric surface. Of the two dielectric substrates tested (FR4 and semi-ceramic (SC)), it is noted that the FR4 is more efficient in terms of time taken for complete inactivation. FR4 is more efficient at generating plasma as shown by the intensity of spectral peaks, amount of ozone generated, the power used and the speed of killing vegetative cells. The surface temperature during plasma generation is also higher in the case of FR4. An inoculated FR4 or SC device produces less ozone than the respective clean devices. Temperature studies show that the surface temperatures reached during plasma generation are in the range of 30°C-66 °C (for FR4) and 20 °C-49 °C (for SC). Surface temperatures during plasma generation of inoculated devices are lower than the corresponding temperatures of clean devices. pH studies indicate a slight reduction in pH value due to plasma generation, which implies that while temperature and acidification may play a minor role in DBD plasma sterilization, the presence of the liquid on the dielectric surface hampers sterilization and as the liquid evaporates, sterilization improves.

Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jablonowski, H.; Hammer, M. U.; Reuter, S.

Plasma medicine utilizes the combined interaction of plasma produced reactive components. These are reactive atoms, molecules, ions, metastable species, and radiation. Here, ultraviolet (UV, 100–400 nm) and, in particular, vacuum ultraviolet (VUV, 10–200 nm) radiation generated by an atmospheric pressure argon plasma jet were investigated regarding plasma emission, absorption in a humidified atmosphere and in solutions relevant for plasma medicine. The energy absorption was obtained for simple solutions like distilled water (dH{sub 2}O) or ultrapure water and sodium chloride (NaCl) solution as well as for more complex ones, for example, Rosewell Park Memorial Institute (RPMI 1640) cell culture media. As moderate stablemore » reactive oxygen species, hydrogen peroxide (H{sub 2}O{sub 2}) was studied. Highly reactive oxygen radicals, namely, superoxide anion (O{sub 2}{sup •−}) and hydroxyl radicals ({sup •}OH), were investigated by the use of electron paramagnetic resonance spectroscopy. All species amounts were detected for three different treatment cases: Plasma jet generated VUV and UV radiation, plasma jet generated UV radiation without VUV part, and complete plasma jet including all reactive components additionally to VUV and UV radiation. It was found that a considerable amount of radicals are generated by the plasma generated photoemission. From the experiments, estimation on the low hazard potential of plasma generated VUV radiation is discussed.« less

Plasma plume MHD power generator and method

DOEpatents

Hammer, J.H.

1993-08-10

A method is described of generating power at a situs exposed to the solar wind which comprises creating at separate sources at the situs discrete plasma plumes extending in opposed directions, providing electrical communication between the plumes at their source and interposing a desired electrical load in the said electrical communication between the plumes.

Generation of zonal flows by electrostatic drift waves in electron-positron-ion plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaladze, T. D.; I. Vekua Institute of Applied Mathematics, Tbilisi State University, 2 University Str., 0186 Tbilisi; Shad, M.

2010-02-15

Generation of large-scale zonal flows by comparatively small-scale electrostatic drift waves in electron-positron-ion plasmas is considered. The generation mechanism is based on the parametric excitation of convective cells by finite amplitude drift waves having arbitrary wavelengths (as compared with the ion Larmor radius of plasma ions at the plasma electron temperature). Temperature inhomogeneity of electrons and positrons is taken into account assuming ions to be cold. To describe the generation of zonal flow generalized Hasegawa-Mima equation containing both vector and two scalar (of different nature) nonlinearities is used. A set of coupled equations describing the nonlinear interaction of drift wavesmore » and zonal flows is deduced. Explicit expressions for the maximum growth rate as well as for the optimal spatial dimensions of the zonal flows are obtained. Enriched possibilities of zonal flow generation with different growth rates are revealed. The present theory can be used for interpretations of drift wave observations in laboratory and astrophysical plasmas.« less

Intermittent laser-plasma interactions and hot electron generation in shock ignition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, R.; Li, J.; Ren, C.

We study laser-plasma interactions and hot electron generation in the ignition phase of shock ignition through 1D and 2D particle-in-cell simulations in the regime of long density scale length and moderately high laser intensity. These long-term simulations show an intermittent bursting pattern of laser-plasma instabilities, resulting from a coupling of the modes near the quarter-critical-surface and those in the lower density region via plasma waves and laser pump depletion. The majority of the hot electrons are found to be from stimulated Raman scattering and of moderate energies. However, high energy electrons of preheating threat can still be generated from themore » two-plasmon-decay instability.« less

Numerical Simulation of Flow in the Chamber of the Water-Argon Plasma Generator

NASA Astrophysics Data System (ADS)

Hlbočan, Peter; Varchola, Michal; Knížat, Branislav; Mlkvik, Marek; Olšiak, Róbert

2012-12-01

The paper describes the CFD simulation of the flow of gas and plasma in a plasma generator with a hybrid stabilization of the electric arc. The momentum equations of the model also take Lorentz forces into account. In the energy equation, Joule heat is introduced as an energy source. The introduction of boundary conditions is also explained, as along with plasma transport properties and a method of solution. The paper presents selected results of pressure and velocity fields in the chamber of the plasma generator.

Study of Plasma Flows Generated in Plasma Focus Discharge in Different Regimes of Working Gas Filling

NASA Astrophysics Data System (ADS)

Voitenko, D. A.; Ananyev, S. S.; Astapenko, G. I.; Basilaia, A. D.; Markolia, A. I.; Mitrofanov, K. N.; Myalton, V. V.; Timoshenko, A. P.; Kharrasov, A. M.; Krauz, V. I.

2017-12-01

Results are presented from experimental studies of the plasma flows generated in the KPF-4 Phoenix Mather-type plasma focus device (Sukhum Physical Technical Institute). In order to study how the formation and dynamics of the plasma flow depend on the initial distribution of the working gas, a system of pulsed gas puffing into the discharge volume was developed. The system allows one to create profiled gas distributions, including those with a reduced gas density in the region of plasma flow propagation. Results of measurements of the magnetic field, flow profile, and flow deceleration dynamics at different initial distributions of the gas pressure are presented.

A New Way to Generate Collimated Plasma Jets?

NASA Astrophysics Data System (ADS)

Young, Rachel; Kuranz, C. C.; Sweeney, R. M.; Drake, R. P.

2012-05-01

We may have a new way to generate collimated, high-Mach-number plasma jets for laboratory astrophysics experiments. Analytic calculations show that irradiating the rear side of a cone-shaped foil can produce a collimated plasma jet with a Mach number of more than 2. Preliminary numeric simulations confirm this. We intend to test this method with a day of experiments at OMEGA (Laboratory for Laser Energetics, Rochester, New York) in April 2012; results may be available in time for this meeting. If successful, this will be the first step in an experimental campaign to investigate the affects of magnetic fields on mixing plasma jets. We hope to create a swirling disk of magnetized plasma_and possibly witness the turbulent dynamo_by firing roughly half a dozen such jets towards each other. However, for such an experiment to succeed, the disk must rotate more quickly than it expands, requiring the contributing jets to have M > 2. This work is funded by the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, grant number DE-FG52-09NA29548, and by the National Laser User Facility Program, grant number DE-NA0000850.

Two-Color Laser High-Harmonic Generation in Cavitated Plasma Wakefields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schroeder, Carl; Benedetti, Carlo; Esarey, Eric

2016-10-03

A method is proposed for producing coherent x-rays via high-harmonic generation using a laser interacting with highly-stripped ions in cavitated plasma wakefields. Two laser pulses of different colors are employed: a long-wavelength pulse for cavitation and a short-wavelength pulse for harmonic generation. This method enables efficient laser harmonic generation in the sub-nm wavelength regime.

Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia

PubMed Central

Gissel, Matthew; Orfeo, Thomas; Foley, Jonathan H; Butenas, Saulius

2012-01-01

Summary Introduction In hemophilia, thrombin generation is significantly suppressed due to decreased factor (F)X activation. Clinical studies and experiments with transgenic mice have suggested that the severity of hemophilia is substantially reduced by tissue factor pathway inhibitor (TFPI) deficiency. Methods We evaluated the effect of TFPI antagonist aptamer BAX499 (formerly ARC19499) on TFPI function in purified systems and on thrombin generation and clot formation in plasma and blood. Results BAX499 effectively neutralized TFPI inhibition of FXa and FXa dependent inhibition of TF/FVIIa by TFPI. BAX499 did not inhibit FXa or TF/FVIIa when used up to 500 nM. In the synthetic coagulation proteome with TFPI at its mean physiologic concentration, BAX499 at 1 – 10 nM increased thrombin generation triggered with 5 pM relipidated TF in a concentration-dependent manner. In severe hemophilia A or B models using the synthetic coagulation proteome, the addition of BAX499 at 5 nM increased thrombin generation to the levels observed in normal control. Thrombin generation measured in induced hemophilia B plasma required ~100 nM BAX499 to restore thrombin levels to those seen in untreated plasma. In induced hemophilia B whole blood, BAX499 repaired the clotting time but failed to appreciably impact the propagation phase of thrombin generation. Conclusion These data suggest that inhibition of TFPI by BAX499 may have potential for hemophilia treatment but requires further study in blood-based hemophilia systems. PMID:22951415

Development of a plasma generator for a long pulse ion source for neutral beam injectors.

PubMed

Watanabe, K; Dairaku, M; Tobari, H; Kashiwagi, M; Inoue, T; Hanada, M; Jeong, S H; Chang, D H; Kim, T S; Kim, B R; Seo, C S; Jin, J T; Lee, K W; In, S R; Oh, B H; Kim, J; Bae, Y S

2011-06-01

A plasma generator for a long pulse H(+)/D(+) ion source has been developed. The plasma generator was designed to produce 65 A H(+)/D(+) beams at an energy of 120 keV from an ion extraction area of 12 cm in width and 45 cm in length. Configuration of the plasma generator is a multi-cusp bucket type with SmCo permanent magnets. Dimension of a plasma chamber is 25 cm in width, 59 cm in length, and 32.5 cm in depth. The plasma generator was designed and fabricated at Japan Atomic Energy Agency. Source plasma generation and beam extraction tests for hydrogen coupling with an accelerator of the KSTAR ion source have been performed at the KSTAR neutral beam test stand under the agreement of Japan-Korea collaborative experiment. Spatial uniformity of the source plasma at the extraction region was measured using Langmuir probes and ±7% of the deviation from an averaged ion saturation current density was obtained. A long pulse test of the plasma generation up to 200 s with an arc discharge power of 70 kW has been successfully demonstrated. The arc discharge power satisfies the requirement of the beam production for the KSTAR NBI. A 70 keV, 41 A, 5 s hydrogen ion beam has been extracted with a high arc efficiency of 0.9 -1.1 A/kW at a beam extraction experiment. A deuteron yield of 77% was measured even at a low beam current density of 73 mA/cm(2). © 2011 American Institute of Physics

Evaluation on nitrogen oxides and nanoparticle removal and nitrogen monoxide generation using a wet-type nonthermal plasma reactor

NASA Astrophysics Data System (ADS)

Takehana, Kotaro; Kuroki, Tomoyuki; Okubo, Masaaki

2018-05-01

Nitrogen oxides (NOx) emitted from power plants and combustion sources cause air pollution problems. Selective catalytic reduction technology is remarkably useful for NOx removal. However, there are several drawbacks such as preparation of reducing agents, usage of harmful heavy metals, and higher cost. On the other hand, trace NO is a vasodilator agent and employed in inhalation therapies for treating pulmonary hypertension in humans. Considering these factors, in the present study, a wet-type nonthermal plasma reactor, which can control NOx and nanoparticle emissions and generate NO, is investigated. The fundamental characteristics of the reactor are investigated. First, the experiment of nanoparticle removal is carried out. Collection efficiencies of over 99% are achieved for nanoparticles at 50 and 100 ml min‑1 of liquid flow rates. Second, experiments of NOx removal under air atmosphere and NOx generation under nitrogen atmosphere are carried out. NOx-removal efficiencies of over 95% under the air plasma are achieved in 50–200 ml min‑1 liquid flow rates. Moreover, under nitrogen plasma, NOx is generated, of which the major portion is NO. For example, NO concentration is 25 ppm, while NOx concentration is 31 ppm at 50 ml min‑1 liquid flow rate. Finally, experiments of NO generation under the nitrogen atmosphere with or without flowing water are carried out. When water flows on the inner surface of the reactor, approximately 14 ppm of NO is generated. Therefore, NO generation requires flowing water. It is considered that the reaction of N and OH, which is similar to the extended Zeldovich mechanism, could occur to induce NO formation. From these results, it is verified that the wet-type plasma reactor is useful for NOx removal and NO generation under nitrogen atmosphere with flowing water.

Preliminary studies for a beam-generated plasma neutralizer test in NIO1

NASA Astrophysics Data System (ADS)

Sartori, E.; Veltri, P.; Balbinot, L.; Cavenago, M.; Veranda, M.; Antoni, V.; Serianni, G.

2017-08-01

The deployment of neutral beam injectors in future fusion plants is beset by the particularly poor efficiency of the neutralization process. Beam-generated plasma neutralizers were proposed as a passive and intrinsically safe scheme of efficient plasma neutralizers. The concept is based on the natural ionization of the gas target by the beam, and on a suitable confinement of the secondary plasma. The technological challenge of such a concept is the magnetic confinement of the secondary plasma: a proof-of-principle for the concept is needed. The possibility to test of such a system in the small negative ion beam system NIO1 is discussed in this paper. The constraints given by the facility are first discussed. A model of beam-gas interaction is developed to provide the charge-state of beam particles along the neutralizer, and to provide the source terms of plasma generation. By using a cylindrical model of plasma diffusion in magnetic fields, the ionization degree of the target is estimated. In the absence of magnetic fields the diffusion model is validated against experimental measurements of the space-charge compensation plasma in the drift region of NIO1. Finally, the feasibility study for a beam-generated plasma neutralizer in NIO is presented. The neutralizer length, required gas target thickness, and a very simple magnetic setup were considered, taking into account the integration in NIO1. For the basic design a low ionization degree (1%) is obtained, however a promising plasma density up to hundred times the beam density was calculated. The proposed test in NIO1 can be the starting point for studying advanced schemes of magnetic confinement aiming at ionization degrees in the order of 10%.

Thrombin generation and fibrin formation under flow on biomimetic tissue factor-rich surfaces.

PubMed

Onasoga-Jarvis, A A; Puls, T J; O'Brien, S K; Kuang, L; Liang, H J; Neeves, K B

2014-01-01

Blood flow regulates coagulation and fibrin assembly by controlling the rate of transport of zymogens, enzymes and plasma proteins to and from the site of an injury. The objective of this work was to define the hemodynamic conditions under which fibrin can form under flow on tissue factor (TF)-rich substrates. TF-coated silica beads (~ 800 nm) were patterned into 18-85-μm spots. Normal pooled plasma and factors VIII, IX and XI deficient plasmas were perfused over the beads coated with 0.08, 0.8 and 8 molecules-TF μm(-2) at shear rates of 50-1000 s(-1) . Fibrin deposition and thrombin generation were measured by fluorescence microscopy in a hydrodynamic focusing microfluidic device. Fibrin deposition was supported on patterned bead spots, but not planar TF substrates at the same surface TF concentration. There was a threshold spot size and a shear rate dependent TF concentration that was necessary to support fibrin polymerization. FVIII and FIX had minor effects on fibrin dynamics at 8 molecules-TF μm(-2) , but were essential at 0.8 molecules-TF μm(-2) . The absence of FXI influenced thrombin generation and fibrin deposition at both 0.8 and 8 molecules-TF μm(-2) . These results show that fibrin deposition requires perturbations in the flow field that protect reactions from dilution by flow under venous and arterial conditions. FVIII and FIX have a modest effect on fibrin deposition at high TF concentrations, but are necessary for fibrin deposition at low TF concentrations. FXI amplifies thrombin generation under flow at both low and high TF concentrations. © 2013 International Society on Thrombosis and Haemostasis.

The role of laser wavelength on plasma generation and expansion of ablation plumes in air

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hussein, A. E.; Department of Physics, McGill University, Montreal, Quebec H3A 0G4; Diwakar, P. K.

2013-04-14

We investigated the role of excitation laser wavelength on plasma generation and the expansion and confinement of ablation plumes at early times (0-500 ns) in the presence of atmospheric pressure. Fundamental, second, and fourth harmonic radiation from Nd:YAG laser was focused on Al target to produce plasma. Shadowgraphy, fast photography, and optical emission spectroscopy were employed to analyze the plasma plumes, and white light interferometry was used to characterize the laser ablation craters. Our results indicated that excitation wavelength plays a crucial role in laser-target and laser-plasma coupling, which in turn affects plasma plume morphology and radiation emission. Fast photographymore » and shadowgraphy images showed that plasmas generated by 1064 nm are more cylindrical compared to plasmas generated by shorter wavelengths, indicating the role of inverse bremsstrahlung absorption at longer laser wavelength excitation. Electron density estimates using Stark broadening showed higher densities for shorter wavelength laser generated plasmas, demonstrating the significance of absorption caused by photoionization. Crater depth analysis showed that ablated mass is significantly higher for UV wavelengths compared to IR laser radiation. In this experimental study, the use of multiple diagnostic tools provided a comprehensive picture of the differing roles of laser absorption mechanisms during ablation.« less

Harmonic generation in magnetized quantum plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Punit; Singh, Abhisek Kumar; Singh, Shiv

2016-05-06

A study of second harmonic generation by propagation of a linearly polarized electromagnetic wave through homogeneous high density quantum plasma in the presence of transverse magnetic field. The nonlinear current density and dispersion relations for the fundamental and second harmonic frequencies have been obtained using the recently developed quantum hydrodynamic (QHD) model. The effect of quantum Bohm potential, Fermi pressure and the electron spin have been taken into account. The second harmonic is found to be less dispersed than the first.

Plasma characterization of the superconducting proton linear accelerator plasma generator using a 2 MHz compensated Langmuir probe.

PubMed

Schmitzer, C; Kronberger, M; Lettry, J; Sanchez-Arias, J; Störi, H

2012-02-01

The CERN study for a superconducting proton Linac (SPL) investigates the design of a pulsed 5 GeV Linac operating at 50 Hz. As a first step towards a future SPL H(-) volume ion source, a plasma generator capable of operating at Linac4 or nominal SPL settings has been developed and operated at a dedicated test stand. The hydrogen plasma is heated by an inductively coupled RF discharge e(-) and ions are confined by a magnetic multipole cusp field similar to the currently commissioned Linac4 H(-) ion source. Time-resolved measurements of the plasma potential, temperature, and electron energy distribution function obtained by means of a RF compensated Langmuir probe along the axis of the plasma generator are presented. The influence of the main tuning parameters, such as RF power and frequency and the timing scheme is discussed with the aim to correlate them to optimum H(-) ion beam parameters measured on an ion source test stand. The effects of hydrogen injection settings which allow operation at 50 Hz repetition rate are discussed.

Plasma characterization of the superconducting proton linear accelerator plasma generator using a 2 MHz compensated Langmuir probea)

NASA Astrophysics Data System (ADS)

Schmitzer, C.; Kronberger, M.; Lettry, J.; Sanchez-Arias, J.; Störi, H.

2012-02-01

The CERN study for a superconducting proton Linac (SPL) investigates the design of a pulsed 5 GeV Linac operating at 50 Hz. As a first step towards a future SPL H- volume ion source, a plasma generator capable of operating at Linac4 or nominal SPL settings has been developed and operated at a dedicated test stand. The hydrogen plasma is heated by an inductively coupled RF discharge e- and ions are confined by a magnetic multipole cusp field similar to the currently commissioned Linac4 H- ion source. Time-resolved measurements of the plasma potential, temperature, and electron energy distribution function obtained by means of a RF compensated Langmuir probe along the axis of the plasma generator are presented. The influence of the main tuning parameters, such as RF power and frequency and the timing scheme is discussed with the aim to correlate them to optimum H- ion beam parameters measured on an ion source test stand. The effects of hydrogen injection settings which allow operation at 50 Hz repetition rate are discussed.

Stability of prothrombin and factor VII in freeze-dried plasma

PubMed Central

Brozović, M.; Gurd, L. J.; Robertson, I.; Bangham, D. R.

1971-01-01

The stability of prothrombin and factor VII was studied using accelerated degradation tests in three preparations of freeze-dried pooled normal plasmas. In a previous report (Brozović, Gurd, Robertson, and Bangham, 1971) factor X was shown to be relatively unstable in these preparations of freeze-dried plasma: it was calculated that up to 8% of the original factor X activity would be lost after 10 years at −20°C, up to 54% at 4°C, and up to 90% at room temperature. The losses of factor VII activity were estimated to be negligible at −20°C, between 2 and 18% at 4°C, and between 20 and 70% of the original activity at 20°C, after 10 years of storage. Prothrombin was found to be less stable than factor VII: the expected loss in 10 years at −20°C may be up to 4%, at 4°C up to 30%, and at 20°C up to 83% of the initial activity. These findings indicate that in freeze-dried plasma prothrombin as well as factor X may be insufficiently stable for plasma to serve as long-term reference material for the standardization of the one-stage prothrombin time. Moreover, the loss of prothrombin and factor X in freeze-dried plasma stored at 4°C may be so high that when it is required to preserve these factors it may be necessary to store freeze-dried plasma at lower temperatures. PMID:5130534

Cold atmospheric plasma jet-generated RONS and their selective effects on normal and carcinoma cells

PubMed Central

Kim, Sun Ja; Chung, T. H.

2016-01-01

Cold atmospheric helium plasma jets were fabricated and utilized for plasma–cell interactions. The effect of operating parameters and jet design on the generation of specific reactive oxygen and nitrogen species (RONS) within cells and cellular response were investigated. It was found that plasma treatment induced the overproduction of RONS in various cancer cell lines selectively. The plasma under a relatively low applied voltage induced the detachment of cells, a reduction in cell viability, and apoptosis, while the plasma under higher applied voltage led to cellular necrosis in our case. To determine whether plasma-induced reactive oxygen species (ROS) generation occurs through interfering with mitochondria-related cellular response, we examined the plasma effects on ROS generation in both parental A549 cells and A549 ρ0 cells. It was observed that cancer cells were more susceptible to plasma-induced RONS (especially nitric oxide (NO) and nitrogen dioxide (NO2−) radicals) than normal cells, and consequently, plasma induced apoptotic cell responses mainly in cancer cells. PMID:26838306

System and method for generating steady state confining current for a toroidal plasma fusion reactor

DOEpatents

Bers, Abraham

1981-01-01

A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma.

Advanced Method of Boundary-Layer Control Based on Localized Plasma Generation

DTIC Science & Technology

2009-05-01

measurements, validation of experiments, wind-tunnel testing of the microwave / plasma generation system , preliminary assessment of energy required...and design of a microwave generator , electrodynamic and multivibrator systems for experiments in the IHM-NAU wind tunnel: MW generator and its high...equipped with the microwave - generation and protection systems to study advanced methods of flow control (Kiev) Fig. 2.1,a. The blade

Generation of plasma X-ray sources via high repetition rate femtosecond laser pulses

NASA Astrophysics Data System (ADS)

Baguckis, Artūras; Plukis, Artūras; Reklaitis, Jonas; Remeikis, Vidmantas; Giniūnas, Linas; Vengris, Mikas

2017-12-01

In this study, we present the development and characterization of Cu plasma X-ray source driven by 20 W average power high repetition rate femtosecond laser in ambient atmosphere environment. The peak Cu- Kα photon flux of 2.3 × 109 photons/s into full solid angle is demonstrated (with a process conversion efficiency of 10-7), using pulses with peak intensity of 4.65 × 1014 W/cm2. Such Cu- Kα flux is significantly larger than others found in comparable experiments, performed in air environment. The effects of resonance plasma absorption process, when optimized, are shown to increase measured flux by the factor of 2-3. The relationship between X-ray photon flux and plasma-driving pulse repetition rate is quasi-linear, suggesting that fluxes could further be increased to 1010 photons/s using even higher average powers of driving radiation. These results suggest that to fully utilize the potential of high repetition rate laser sources, novel target material delivery systems (for example, jet-based ones) are required. On the other hand, this study demonstrates that high energy lasers currently used for plasma X-ray sources can be conveniently and efficiently replaced by high average power and repetition rate laser radiation, as a way to increase the brightness of the generated X-rays.

Non-inductive current generation in fusion plasmas with turbulence

NASA Astrophysics Data System (ADS)

Wang, Weixing; Ethier, S.; Startsev, E.; Chen, J.; Hahm, T. S.; Yoo, M. G.

2017-10-01

It is found that plasma turbulence may strongly influence non-inductive current generation. This may have radical impact on various aspects of tokamak physics. Our simulation study employs a global gyrokinetic model coupling self-consistent neoclassical and turbulent dynamics with focus on electron current. Distinct phases in electron current generation are illustrated in the initial value simulation. In the early phase before turbulence develops, the electron bootstrap current is established in a time scale of a few electron collision times, which closely agrees with the neoclassical prediction. The second phase follows when turbulence begins to saturate, during which turbulent fluctuations are found to strongly affect electron current. The profile structure, amplitude and phase space structure of electron current density are all significantly modified relative to the neoclassical bootstrap current by the presence of turbulence. Both electron parallel acceleration and parallel residual stress drive are shown to play important roles in turbulence-induced current generation. The current density profile is modified in a way that correlates with the fluctuation intensity gradient through its effect on k//-symmetry breaking in fluctuation spectrum. Turbulence is shown to deduct (enhance) plasma self-generated current in low (high) collisionality regime, and the reduction of total electron current relative to the neoclassical bootstrap current increases as collisionality decreases. The implication of this result to the fully non-inductive current operation in steady state burning plasma regime should be investigated. Finally, significant non-inductive current is observed in flat pressure region, which is a nonlocal effect and results from turbulence spreading induced current diffusion. Work supported by U.S. DOE Contract DE-AC02-09-CH11466.

Adjustable, High Voltage Pulse Generator with Isolated Output for Plasma Processing

NASA Astrophysics Data System (ADS)

Ziemba, Timothy; Miller, Kenneth E.; Prager, James; Slobodov, Ilia

2015-09-01

Eagle Harbor Technologies (EHT), Inc. has developed a high voltage pulse generator with isolated output for etch, sputtering, and ion implantation applications within the materials science and semiconductor processing communities. The output parameters are independently user adjustable: output voltage (0 - 2.5 kV), pulse repetition frequency (0 - 100 kHz), and duty cycle (0 - 100%). The pulser can drive loads down to 200 Ω. Higher voltage pulsers have also been tested. The isolated output allows the pulse generator to be connected to loads that need to be biased. These pulser generators take advantage modern silicon carbide (SiC) MOSFETs. These new solid-state switches decrease the switching and conduction losses while allowing for higher switching frequency capabilities. This pulse generator has applications for RF plasma heating; inductive and arc plasma sources; magnetron driving; and generation of arbitrary pulses at high voltage, high current, and high pulse repetition frequency. This work was supported in part by a DOE SBIR.

Helicon wave-generated plasmas for negative ion beams for fusion

NASA Astrophysics Data System (ADS)

Furno, Ivo; Agnello, Riccardo; Fantz, U.; Howling, Alan; Jacquier, Remy; Marini, Claudio; Plyushchev, Gennady; Guittienne, Philippe; Simonin, Alain

2017-10-01

In the next generation of fusion reactors, such as DEMO, neutral beam injectors (NBIs) of high energy (0.8-1 MeV) deuterium atoms with high wall-plug efficiency (>50%) will be required to reach burning plasma conditions and to provide a significant amount of current drive. The present NBI system for DEMO assumes that 50 MW is delivered to the plasma by 3 NBIs. In the Siphore NBI concept, negative deuterium ions are extracted from a long, thin ion source 3 m high and 15 cm wide, accelerated and subsequently photo-neutralized. This requires the development of a new generation of negative ion sources. At the Swiss Plasma Center, a novel radio frequency helicon plasma source, based on a resonant network antenna source delivering up to 10 kW at 13.56 MHz, has been developed and is presently under study on the Resonant Antenna Ion Device (RAID). RAID is a linear device (1.9 m total length, 0.4 m diameter) and is equipped with an extensive set of diagnostics for full plasma characterization. In this work, the principles of operation of resonant antennas as helicon sources are introduced. We present absolute spectroscopy, Langmuir probe, and interferometry measurements on helicon plasmas. We characterize the performance of the source in terms of hydrogen/deuterium dissociation and negative ion production as a function of the input power. Furthermore, first results with the helicon birdcage antenna installed on the Cybele negative ion source at CEA-IRFM are presented, as a first step towards the validation of the Siphore concept.

Next Generation Driver for Attosecond and Laser-plasma Physics.

PubMed

Rivas, D E; Borot, A; Cardenas, D E; Marcus, G; Gu, X; Herrmann, D; Xu, J; Tan, J; Kormin, D; Ma, G; Dallari, W; Tsakiris, G D; Földes, I B; Chou, S-W; Weidman, M; Bergues, B; Wittmann, T; Schröder, H; Tzallas, P; Charalambidis, D; Razskazovskaya, O; Pervak, V; Krausz, F; Veisz, L

2017-07-12

The observation and manipulation of electron dynamics in matter call for attosecond light pulses, routinely available from high-order harmonic generation driven by few-femtosecond lasers. However, the energy limitation of these lasers supports only weak sources and correspondingly linear attosecond studies. Here we report on an optical parametric synthesizer designed for nonlinear attosecond optics and relativistic laser-plasma physics. This synthesizer uniquely combines ultra-relativistic focused intensities of about 10 20  W/cm 2 with a pulse duration of sub-two carrier-wave cycles. The coherent combination of two sequentially amplified and complementary spectral ranges yields sub-5-fs pulses with multi-TW peak power. The application of this source allows the generation of a broad spectral continuum at 100-eV photon energy in gases as well as high-order harmonics in relativistic plasmas. Unprecedented spatio-temporal confinement of light now permits the investigation of electric-field-driven electron phenomena in the relativistic regime and ultimately the rise of next-generation intense isolated attosecond sources.

Apparatus for recording emissions from a rapidly generated plasma from a single plasma producing event

DOEpatents

Tan, Tai Ho; Williams, Arthur H.

1985-01-01

An optical fiber-coupled detector visible streak camera plasma diagnostic apparatus. Arrays of optical fiber-coupled detectors are placed on the film plane of several types of particle, x-ray and visible spectrometers or directly in the path of the emissions to be measured and the output is imaged by a visible streak camera. Time and spatial dependence of the emission from plasmas generated from a single pulse of electromagnetic radiation or from a single particle beam burst can be recorded.

Apparatus for recording emissions from a rapidly generated plasma from a single plasma producing event

DOEpatents

Tan, T.H.; Williams, A.H.

An optical fiber-coupled detector visible streak camera plasma diagnostic apparatus. Arrays of optical fiber-coupled detectors are placed on the film plane of several types of particle, x-ray and visible spectrometers or directly in the path of the emissions to be measured and the output is imaged by a visible streak camera. Time and spatial dependence of the emission from plasma generated from a single pulse of electromagnetic radiation or from a single particle beam burst can be recorded.

Third harmonic generation in air ambient and laser ablated carbon plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Ravi Pratap, E-mail: ravips@iitk.ac.in; Gupta, Shyam L.; Thareja, Raj K.

2015-12-15

We report the third harmonic generation of a nanosecond laser pulse (1.06 μm) in air ambient and in the presence of nanoparticles from laser ablated carbon plasma. Significant decrease in the threshold of third harmonic generation and multi-fold increment in the intensity of generated third harmonic is observed in presence of carbon plasma. The third harmonic in air is due to the quasi-resonant four photon process involving vibrationally excited states of molecular ion of nitrogen due to electron impact ionization and laser pulse. Following optical emission spectroscopic observations we conclude that the presence of C{sub 2} and CN in the ablatedmore » plume play a vital role in the observed third harmonic signals.« less

Advanced properties of extended plasmas for efficient high-order harmonic generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ganeev, R. A.; Physics Department, Voronezh State University, Voronezh 394006; Suzuki, M.

We demonstrate the advanced properties of extended plasma plumes (5 mm) for efficient harmonic generation of laser radiation compared with the short lengths of plasmas (∼0.3–0.5 mm) used in previous studies. The harmonic conversion efficiency quadratically increased with the growth of plasma length. The studies of this process along the whole extreme ultraviolet range using the long plasma jets produced on various metal surfaces, particularly including the resonance-enhanced laser frequency conversion and two-color pump, are presented. Such plasmas could be used for the quasi-phase matching experiments by proper modulation of the spatial characteristics of extended ablating area and formation of separated plasmamore » jets.« less

Miniature microwave plasmas generated in high pressure argon

NASA Astrophysics Data System (ADS)

Inoue, Kenichi; Stauss, Sven; Kim, Jaeho; Ito, Tsuyohito; Terashima, Kazuo

2018-05-01

Miniature microwave plasmas with diameters of approximately 1 mm were generated in high-pressure argon (0.1–5.0 MPa) using a microgap electrode. The microwave power required to sustain plasmas was 1–10 W, depending on the pressure. Strong electron-neutral bremsstrahlung emission, indicating an electron temperature of approximately 12000 K, was observed at high pressures (>1 MPa), and electron densities estimated from Stark broadening revealed high values on the order of 1023 m‑3. The analysis confirmed that the coefficient for the pressure shift of the Ar I line at 696.5 nm reported by Copley and Camm can be extended to 5 MPa.

High-energy-density plasma jet generated by laser-cone interaction

NASA Astrophysics Data System (ADS)

Ke, Y. Z.; Yang, X. H.; Ma, Y. Y.; Xu, B. B.; Ge, Z. Y.; Gan, L. F.; Meng, L.; Wang, S. W.; Kawata, S.

2018-04-01

The generation of high-energy-density (HED) plasma jet from a laser ablating thin cone target is studied theoretically and by numerical simulations. Theoretical analysis and 1D simulations show that a maximum kinetic energy conversion efficiency (CE) of 26% can be achieved when nearly 80% of the foil is ablated by laser. A HED plasma jet is generated when an intense laser (˜1015 W/cm2) irradiates the cone target, inducing a great enhancement of energy density compared to that of the planar target, which is attributed to the cumulative effect of the cone shape and the new generation mechanism of jet, i.e., laser directly accelerating the cone wall onto the axis. The characteristic of jet is influenced by the cone geometry, i.e., thickness and cone angle. It is found that a cone with a half opening angle around 70 ° and the optimized thickness (˜5 μm) can induce a jet with a high CE and long duration, whose peak energy density can reach 3.5 × 1015 erg/cm3. The results can be beneficial for laser-driven novel neutron sources and other fusion related experiments, where HED plasma jet can be applied.

Method for generating a plasma wave to accelerate electrons

DOEpatents

Umstadter, D.; Esarey, E.; Kim, J.K.

1997-06-10

The invention provides a method and apparatus for generating large amplitude nonlinear plasma waves, driven by an optimized train of independently adjustable, intense laser pulses. In the method, optimal pulse widths, interpulse spacing, and intensity profiles of each pulse are determined for each pulse in a series of pulses. A resonant region of the plasma wave phase space is found where the plasma wave is driven most efficiently by the laser pulses. The accelerator system of the invention comprises several parts: the laser system, with its pulse-shaping subsystem; the electron gun system, also called beam source, which preferably comprises photo cathode electron source and RF-LINAC accelerator; electron photo-cathode triggering system; the electron diagnostics; and the feedback system between the electron diagnostics and the laser system. The system also includes plasma source including vacuum chamber, magnetic lens, and magnetic field means. The laser system produces a train of pulses that has been optimized to maximize the axial electric field amplitude of the plasma wave, and thus the electron acceleration, using the method of the invention. 21 figs.

Method for generating a plasma wave to accelerate electrons

DOEpatents

Umstadter, Donald; Esarey, Eric; Kim, Joon K.

1997-01-01

The invention provides a method and apparatus for generating large amplitude nonlinear plasma waves, driven by an optimized train of independently adjustable, intense laser pulses. In the method, optimal pulse widths, interpulse spacing, and intensity profiles of each pulse are determined for each pulse in a series of pulses. A resonant region of the plasma wave phase space is found where the plasma wave is driven most efficiently by the laser pulses. The accelerator system of the invention comprises several parts: the laser system, with its pulse-shaping subsystem; the electron gun system, also called beam source, which preferably comprises photo cathode electron source and RF-LINAC accelerator; electron photo-cathode triggering system; the electron diagnostics; and the feedback system between the electron diagnostics and the laser system. The system also includes plasma source including vacuum chamber, magnetic lens, and magnetic field means. The laser system produces a train of pulses that has been optimized to maximize the axial electric field amplitude of the plasma wave, and thus the electron acceleration, using the method of the invention.

Characteristics of chiral plasma plumes generated in the absence of external magnetic field

NASA Astrophysics Data System (ADS)

Nie, LanLan; Liu, FengWu; Zhou, XinCai; Lu, XinPei; Xian, YuBin

2018-05-01

A chiral plasma plume has recently been generated inside a dielectric tube without the use of an external magnetic field. In this paper, we seek to further study the key properties of such a chiral plume to improve our understanding of how this interesting structure is generated and controlled. The chiral plume is generated by externally mounting a stainless steel helical coil or a ring onto the dielectric tube. By changing the pitch of the helical coil, the pitch of the plasma plume can be controlled, with the shape of the plume following the shape of the helical coil. The addition of the helical coil significantly expands the range of parameters under which the chiral plasma plume appears. When the frequency of the applied voltage increases, additional stable discharge channels appear between the adjacent helices. The addition of two helical coils results in the formation of two chiral plasma plumes, which follow the shape of the helical coils. When a metal ring is placed on the outside of the tube, there is no chiral plasma plume between the high voltage electrode and the ring; however, a chiral plasma plume appears on the right side of the ring if the distance between the ring and the high voltage electrode is small. These findings suggest that the chiral plasma can be effectively modulated and guided using an externally mounted helical coil, which acts as the floating/actual ground to reduce the impedance of the discharge and as such contributes to the emergence of the chiral plasma plume behavior.

System and method for generating steady state confining current for a toroidal plasma fusion reactor

DOEpatents

Fisch, Nathaniel J.

1981-01-01

A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma.

Targeting Cancer Cells with Reactive Oxygen and Nitrogen Species Generated by Atmospheric-Pressure Air Plasma

PubMed Central

Hoan, Nguyen Ngoc; Kim, Churl Ho; Moon, Eunpyo; Choi, Kyeong Sook; Yang, Sang Sik; Lee, Jong-Soo

2014-01-01

The plasma jet has been proposed as a novel therapeutic method for cancer. Anticancer activity of plasma has been reported to involve mitochondrial dysfunction. However, what constituents generated by plasma is linked to this anticancer process and its mechanism of action remain unclear. Here, we report that the therapeutic effects of air plasma result from generation of reactive oxygen/nitrogen species (ROS/RNS) including H2O2, Ox, OH−, •O2, NOx, leading to depolarization of mitochondrial membrane potential and mitochondrial ROS accumulation. Simultaneously, ROS/RNS activate c-Jun NH2-terminal kinase (JNK) and p38 kinase. As a consequence, treatment with air plasma jets induces apoptotic death in human cervical cancer HeLa cells. Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis. Therefore, administration of air plasma may be a feasible strategy to eliminate cancer cells. PMID:24465942

Volumetric Near-Field Microwave Plasma Generation

NASA Technical Reports Server (NTRS)

Exton, R. J.; Balla, R. Jeffrey; Herring, G. C.; Popovic, S.; Vuskovic, L.

2003-01-01

A periodic series of microwave-induced plasmoids is generated using the outgoing wave from a microwave horn and the reflected wave from a nearby on-axis concave reflector. The plasmoids are spaced at half-wavelength separations according to a standing-wave pattern. The plasmoids are enhanced by an effective focusing in the near field of the horn (Fresnel region) as a result of a diffractive narrowing. Optical imaging, electron density, and rotational temperature measurements characterize the near field plasma region. Volumetric microwave discharges may have application to combustion ignition in scramjet engines.

Suppression of high-energy electrons generated in both disrupting and sustained MST tokamak plasmas

NASA Astrophysics Data System (ADS)

Pandya, M. D.; Chapman, B. E.; Munaretto, S.; Cornille, B. S.; McCollam, K. J.; Sovinec, C. R.; Dubois, A. M.; Almagri, A. F.; Goetz, J. A.

2017-10-01

High-energy electrons appearing during MST tokamak plasma disruptions are rapidly lost from the plasma due apparently to internal MHD activity. Work has just recently begun on generating and diagnosing disruptions in MST tokamak plasmas. Initial measurements show the characteristic drop in central temperature and density preceding a quench of the plasma current. This corresponds to a burst of dominantly n=1 MHD activity, which is accompanied by a short-lived burst of high-energy electrons. The short-lived nature of these electrons is suspected to be due to stochastic transport associated with the increased MHD. Earlier work shows that runaway electrons generated in low density, sustained plasmas are suppressed by a sufficiently large m=3 RMP in plasmas with q(a) <3. RMPs of various poloidal mode number can be generated with an array of saddle coils wound around the vertical insulated gap in MST's thick conducting shell. With an m=3 RMP, the degree of runaway suppression increases with RMP amplitude, while an m=1 RMP has little effect on the runaways. Nonlinear MHD modeling with NIMROD of these MST plasmas indicates increased stochasticity with an m=3 RMP, while no such increase in stochasticity is observed with an m=1 RMP. Work supported by US DOE.

Study on the plasma generation characteristics of an induction-triggered coaxial pulsed plasma thruster

NASA Astrophysics Data System (ADS)

Weisheng, CUI; Wenzheng, LIU; Jia, TIAN; Xiuyang, CHEN

2018-02-01

At present, spark plugs are used to trigger discharge in pulsed plasma thrusters (PPT), which are known to be life-limiting components due to plasma corrosion and carbon deposition. A strong electric field could be formed in a cathode triple junction (CTJ) to achieve a trigger function under vacuum conditions. We propose an induction-triggered electrode structure on the basis of the CTJ trigger principle. The induction-triggered electrode structure could increase the electric field strength of the CTJ without changing the voltage between electrodes, contributing to a reduction in the electrode breakdown voltage. Additionally, it can maintain the plasma generation effect when the breakdown voltage is reduced in the discharge experiments. The induction-triggered electrode structure could ensure an effective trigger when the ablation distance of Teflon increases, and the magnetic field produced by the discharge current could further improve the plasma density and propagation velocity. The induction-triggered coaxial PPT we propose has a simplified trigger structure, and it is an effective attempt to optimize the micro-satellite thruster.

Secondary electron emission from plasma-generated nanostructured tungsten fuzz

DOE PAGES

Patino, M.; Raitses, Y.; Wirz, R.

2016-11-14

Recently, several researchers (e.g., Q. Yang, Y.-W. You, L. Liu, H. Fan, W. Ni, D. Liu, C. S. Liu, G. Benstetter, and Y. Wang, Scientific Reports 5, 10959 (2015)) have shown that tungsten fuzz can grow on a hot tungsten surface under bombardment by energetic helium ions in different plasma discharges and applications, including magnetic fusion devices with plasma facing tungsten components. This work reports direct measurements of the total effective secondary electron emission (SEE) from tungsten fuzz. Using dedicated material surface diagnostics and in-situ characterization, we find two important results: (1) SEE values for tungsten fuzz are 40-63% lowermore » than for smooth tungsten and (2) the SEE values for tungsten fuzz are independent of the angle of the incident electron. The reduction in SEE from tungsten fuzz is most pronounced at high incident angles, which has important implications for many plasma devices since in a negative-going sheath the potential structure leads to relatively high incident angles for the electrons at the plasma confining walls. Overall, low SEE will create a relatively higher sheath potential difference that reduces plasma electron energy loss to the confining wall. Thus the presence or self-generation in a plasma of a low SEE surface such as tungsten fuzz can be desirable for improved performance of many plasma devices.:7px« less

Magnetic filter apparatus and method for generating cold plasma in semicoductor processing

DOEpatents

Vella, Michael C.

1996-01-01

Disclosed herein is a system and method for providing a plasma flood having a low electron temperature to a semiconductor target region during an ion implantation process. The plasma generator providing the plasma is coupled to a magnetic filter which allows ions and low energy electrons to pass therethrough while retaining captive the primary or high energy electrons. The ions and low energy electrons form a "cold plasma" which is diffused in the region of the process surface while the ion implantation process takes place.

Magnetic filter apparatus and method for generating cold plasma in semiconductor processing

DOEpatents

Vella, M.C.

1996-08-13

Disclosed herein is a system and method for providing a plasma flood having a low electron temperature to a semiconductor target region during an ion implantation process. The plasma generator providing the plasma is coupled to a magnetic filter which allows ions and low energy electrons to pass therethrough while retaining captive the primary or high energy electrons. The ions and low energy electrons form a ``cold plasma`` which is diffused in the region of the process surface while the ion implantation process takes place. 15 figs.

Generation of a wakefield undulator in plasma with transverse density gradient

DOE PAGES

Stupakov, Gennady V.

2017-11-30

Here, we show that a short relativistic electron beam propagating in a plasma with a density gradient perpendicular to the direction of motion generates a wakefield in which a witness bunch experiences a transverse force. A density gradient oscillating along the beam path would create a periodically varying force$-$an undulator, with an estimated strength of the equivalent magnetic field more than ten Tesla. This opens an avenue for creation of a high-strength, short-period undulators, which eventually may lead to all-plasma, free electron lasers where a plasma wakefield acceleration is naturally combined with a plasma undulator in a unifying, compact setup.

Generation of a wakefield undulator in plasma with transverse density gradient

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stupakov, Gennady V.

Here, we show that a short relativistic electron beam propagating in a plasma with a density gradient perpendicular to the direction of motion generates a wakefield in which a witness bunch experiences a transverse force. A density gradient oscillating along the beam path would create a periodically varying force$-$an undulator, with an estimated strength of the equivalent magnetic field more than ten Tesla. This opens an avenue for creation of a high-strength, short-period undulators, which eventually may lead to all-plasma, free electron lasers where a plasma wakefield acceleration is naturally combined with a plasma undulator in a unifying, compact setup.

Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock.

PubMed

Hellum, Marit; Øvstebø, Reidun; Brusletto, Berit S; Berg, Jens P; Brandtzaeg, Petter; Henriksson, Carola E

2014-03-01

The plasma level of bacterial lipopolysaccharides (LPS) is associated with activation of the coagulation system, inhibition of fibrinolysis and the nature of the clinical presentation and outcome in patients with meningococcal disease. Tissue factor (TF)-bearing microparticles (MPs) appear to contribute to the pathogenesis of disseminated intravascular coagulation (DIC). The aim of this study was to investigate the relationship between MP-associated TF activity and the level of bacterial LPS in plasma from patients with meningococcal septic shock and meningitis. MPs isolated from citrated plasmas were assessed for TF-dependent activity with both a plasma-based thrombin generation assay (CAT) and whole blood-based thromboelastometry (ROTEM). The LPS level was measured using a chromogenic Limulus amebocyte lysate assay. MPs obtained from patients with meningococcal septic shock initiated significantly more efficient and TF-dependent thrombin generation in the CAT assay compared to MPs from patients with meningococcal meningitis. Differences in MP-associated TF activity between the septic shock patients and the meningitis patients were also evident when MPs were added to whole blood using ROTEM. The level of plasma LPS in patients with septic shock (range 2-2,100 EU/mL) was correlated with thrombogram parameters in the CAT assay; lagtime (r(s)=-0.84), time to peak (rs=-0.83), peak (r(s)=0.85) and ETP (r(s)=0.83). MPs obtained from patients with meningococcal septic shock displayed more efficient TF-dependent thrombin generation and clot formation compared to MPs from meningitis patients. MP-associated TF activity was closely associated with plasma LPS levels in the septic shock group. Copyright © 2013 Elsevier Ltd. All rights reserved.

Microwave plasma generation of arsine from hydrogen and solid arsenic

NASA Astrophysics Data System (ADS)

Omstead, Thomas R.; Annapragada, Ananth V.; Jensen, Klavs F.

1990-12-01

The generation of arsine from the reactions of hydrogen and elemental arsenic in a microwave plasma reactor is described. The arsenic is evaporated from a solid source upstream and carried into the microwave plasma region by a mixture of hydrogen and argon. Stable reaction products, arsine and diarsine are observed by molecular beam sampled mass spectroscopy along with partially hydrogenated species (e.g., AsH and AsH2). The effect of composition and flow rate of the argon/hydrogen carrier gas mixture on the amount of arsine generated is investigated. The arsine production reaches a maximum for an argon-to-hydrogen ratio of unity indicating that metastable argon species act as energy transfer intermediates in the overall reaction. The generation of arsine and diarsine from easily handled solid arsenic by this technique makes it attractive as a possible arsenic source for the growth of compound semiconductors by low-pressure metalorganic chemical vapor deposition.

Electrostatic wave heating and possible formation of self-generated high electric fields in a magnetized plasma

NASA Astrophysics Data System (ADS)

Mascali, D.; Celona, L.; Gammino, S.; Miracoli, R.; Castro, G.; Gambino, N.; Ciavola, G.

2011-10-01

A plasma reactor operates at the Laboratori Nazionali del Sud of INFN, Catania, and it has been used as a test-bench for the investigation of innovative mechanisms of plasma ignition based on electrostatic waves (ES-W), obtained via the inner plasma EM-to-ES wave conversion. Evidences of Bernstein wave (BW) generation will be shown. The Langmuir probe measurements have revealed a strong increase of the ion saturation current, where the BW are generated or absorbed, this being a signature of possible high energy ion flows. The results are interpreted through the Bernstein wave heating theory, which predicts the formation of high speed rotating layers of the plasma (a dense plasma ring is in fact observed). High intensity inner plasma self-generated electric fields (on the order of several tens of kV/cm) come out by our calculations.

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

PubMed Central

Tilley, Derek; Levit, Irina; Samis, John A.

2012-01-01

In response to injury, blood coagulation is activated and results in generation of the clotting protease, thrombin. Thrombin cleaves fibrinogen to fibrin which forms an insoluble clot that stops hemorrhage. Factor V (FV) in its activated form, FVa, is a critical cofactor for the protease FXa and accelerator of thrombin generation during fibrin clot formation as part of prothrombinase 1, 2. Manual FV assays have been described 3, 4, but they are time consuming and subjective. Automated FV assays have been reported 5-7, but the analyzer and reagents are expensive and generally provide only the clot time, not the rate and extent of fibrin formation. The microplate platform is preferred for measuring enzyme-catalyzed events because of convenience, time, cost, small volume, continuous monitoring, and high-throughput 8, 9. Microplate assays have been reported for clot lysis 10, platelet aggregation 11, and coagulation Factors 12, but not for FV activity in human plasma. The goal of the method was to develop a microplate assay that measures FV activity during fibrin formation in human plasma. This novel microplate method outlines a simple, inexpensive, and rapid assay of FV activity in human plasma. The assay utilizes a kinetic microplate reader to monitor the absorbance change at 405nm during fibrin formation in human plasma (Figure 1) 13. The assay accurately measures the time, initial rate, and extent of fibrin clot formation. It requires only μl quantities of plasma, is complete in 6 min, has high-throughput, is sensitive to 24-80pM FV, and measures the amount of unintentionally activated (1-stage activity) and thrombin-activated FV (2-stage activity) to obtain a complete assessment of its total functional activity (2-stage activity - 1-stage activity). Disseminated intravascular coagulation (DIC) is an acquired coagulopathy that most often develops from pre-existing infections 14. DIC is associated with a poor prognosis and increases mortality above the pre

Measurement of factor v activity in human plasma using a microplate coagulation assay.

PubMed

Tilley, Derek; Levit, Irina; Samis, John A

2012-09-09

In response to injury, blood coagulation is activated and results in generation of the clotting protease, thrombin. Thrombin cleaves fibrinogen to fibrin which forms an insoluble clot that stops hemorrhage. Factor V (FV) in its activated form, FVa, is a critical cofactor for the protease FXa and accelerator of thrombin generation during fibrin clot formation as part of prothrombinase (1, 2). Manual FV assays have been described (3, 4), but they are time consuming and subjective. Automated FV assays have been reported (5-7), but the analyzer and reagents are expensive and generally provide only the clot time, not the rate and extent of fibrin formation. The microplate platform is preferred for measuring enzyme-catalyzed events because of convenience, time, cost, small volume, continuous monitoring, and high-throughput (8, 9). Microplate assays have been reported for clot lysis (10), platelet aggregation (11), and coagulation Factors (12), but not for FV activity in human plasma. The goal of the method was to develop a microplate assay that measures FV activity during fibrin formation in human plasma. This novel microplate method outlines a simple, inexpensive, and rapid assay of FV activity in human plasma. The assay utilizes a kinetic microplate reader to monitor the absorbance change at 405 nm during fibrin formation in human plasma (Figure 1) (13). The assay accurately measures the time, initial rate, and extent of fibrin clot formation. It requires only μl quantities of plasma, is complete in 6 min, has high-throughput, is sensitive to 24-80 pM FV, and measures the amount of unintentionally activated (1-stage activity) and thrombin-activated FV (2-stage activity) to obtain a complete assessment of its total functional activity (2-stage activity - 1-stage activity). Disseminated intravascular coagulation (DIC) is an acquired coagulopathy that most often develops from pre-existing infections (14). DIC is associated with a poor prognosis and increases mortality

Stable generation of GeV-class electron beams from self-guided laser-plasma channels

NASA Astrophysics Data System (ADS)

Hafz, Nasr A. M.; Jeong, Tae Moon; Choi, Il Woo; Lee, Seong Ku; Pae, Ki Hong; Kulagin, Victor V.; Sung, Jae Hee; Yu, Tae Jun; Hong, Kyung-Han; Hosokai, Tomonao; Cary, John R.; Ko, Do-Kyeong; Lee, Jongmin

2008-09-01

Table-top laser-driven plasma accelerators are gaining attention for their potential use in miniaturizing future high-energy accelerators. By irradiating gas jet targets with ultrashort intense laser pulses, the generation of quasimonoenergetic electron beams was recently observed. Currently, the stability of beam generation and the ability to scale to higher electron beam energies are critical issues for practical laser acceleration. Here, we demonstrate the first generation of stable GeV-class electron beams from stable few-millimetre-long plasma channels in a self-guided wakefield acceleration process. As primary evidence of the laser wakefield acceleration in a bubble regime, we observed a boost of both the electron beam energy and quality by reducing the plasma density and increasing the plasma length in a 1-cm-long gas jet. Subsequent three-dimensional simulations show the possibility of achieving even higher electron beam energies by minimizing plasma bubble elongation, and we anticipate dramatic increases in beam energy and quality in the near future. This will pave the way towards ultracompact, all-optical electron beam accelerators and their applications in science, technology and medicine.

Plasma and Shock Generation by Indirect Laser Pulse Action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasperczuk, A.; Borodziuk, S.; Pisarczyk, T.

2006-01-15

In the paper the results of our experiment with flyer disks, accelerated to high velocities by the PALS iodine laser and subsequently creating craters when hitting massive targets , are presented. We have carried out experiments with the double targets consisted of a disk placed in front of a massive target part at distances of either 200 or 500 {mu}m. Both elements of the targets were made of Al. The following disk irradiation conditions were used: laser energy of 130 J, laser wavelength of 1.315 {mu}m, pulse duration of 0.4 ns, and laser spot diameter of 250 {mu}m. To measuremore » some plasma parameters and accelerated disk velocity a three frame interferometric system was used. Efficiency of crater creation by a disk impact was determined from the crater parameters, which were obtained by means of a crater replica technique. The experimental results concern two main stages: (a) ablative plasma generation and disk acceleration and (b) disk impact and crater creation. Spatial density distributions at different moments of plasma generation and expansion are shown. Discussion of the experimental results on the basis of a 2-D theoretical model of the laser -- solid target interaction is carried out.« less

Gene expression responses of HeLa cells to chemical species generated by an atmospheric plasma flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yokoyama, Mayo, E-mail: yokoyama@plasma.ifs.tohoku.ac.jp; Johkura, Kohei, E-mail: kohei@shinshu-u.ac.jp; Sato, Takehiko, E-mail: sato@ifs.tohoku.ac.jp

2014-08-08

Highlights: • Response of HeLa cells to a plasma-irradiated medium was revealed by DNA microarray. • Gene expression pattern was basically different from that in a H{sub 2}O{sub 2}-added medium. • Prominently up-/down-regulated genes were partly shared by the two media. • Gene ontology analysis showed both similar and different responses in the two media. • Candidate genes involved in response to ROS were detected in each medium. - Abstract: Plasma irradiation generates many factors able to affect the cellular condition, and this feature has been studied for its application in the field of medicine. We previously reported that hydrogenmore » peroxide (H{sub 2}O{sub 2}) was the major cause of HeLa cell death among the chemical species generated by high level irradiation of a culture medium by atmospheric plasma. To assess the effect of plasma-induced factors on the response of live cells, HeLa cells were exposed to a medium irradiated by a non-lethal plasma flow level, and their gene expression was broadly analyzed by DNA microarray in comparison with that in a corresponding concentration of 51 μM H{sub 2}O{sub 2}. As a result, though the cell viability was sufficiently maintained at more than 90% in both cases, the plasma-medium had a greater impact on it than the H{sub 2}O{sub 2}-medium. Hierarchical clustering analysis revealed fundamentally different cellular responses between these two media. A larger population of genes was upregulated in the plasma-medium, whereas genes were downregulated in the H{sub 2}O{sub 2}-medium. However, a part of the genes that showed prominent differential expression was shared by them, including an immediate early gene ID2. In gene ontology analysis of upregulated genes, the plasma-medium showed more diverse ontologies than the H{sub 2}O{sub 2}-medium, whereas ontologies such as “response to stimulus” were common, and several genes corresponded to “response to reactive oxygen species.” Genes of AP-1 proteins, e

Generation of Currents in Weakly Ionized Plasmas through a Collisional Dynamo

NASA Astrophysics Data System (ADS)

Dimant, Yakov; Oppenheim, Meers; Fletcher, Alex

2016-10-01

Intense electric currents called electrojets occur in weakly ionized magnetized plasmas. An example occurs in the Earth's ionosphere near the magnetic equator where neutral winds drive the plasma across the geomagnetic field. Similar processes take place in the Solar chromosphere and MHD generators. We argue that not all convective neutral flows generate electrojets and it introduces the corresponding universal criterion for the current formation, ∇ × (U-> × B->) ≠ ∂ B-> / ∂ t , where U-> is the neutral flow velocity, B-> is the magnetic field, and t is time. This criterion does not depend on the conductivity tensor, σ̂ . For many systems, the displacement current, ∂ B-> / ∂ t , is negligible, making the criterion even simpler. This theory also shows that the neutral-dynamo driver that generates electrojets plays the same role as the DC electric current plays for the generation of the magnetic field in the Biot-Savart law. Work supported by NSF/DOE Grant PHY-1500439.

Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.

PubMed

Thomas, Christopher P; Morgan, Lloyd T; Maskrey, Benjamin H; Murphy, Robert C; Kühn, Hartmut; Hazen, Stanley L; Goodall, Alison H; Hamali, Hassan A; Collins, Peter W; O'Donnell, Valerie B

2010-03-05

Here, a group of specific lipids, comprising phosphatidylethanolamine (PE)- or phosphatidylcholine (PC)-esterified 12S-hydroxyeicosatetraenoic acid (12S-HETE), generated by 12-lipoxygenase was identified and characterized. 12S-HETE-PE/PCs were formed within 5 min of activation by thrombin, ionophore, or collagen. Esterified HETE levels generated in response to thrombin were 5.85 +/- 1.42 (PE) or 18.35 +/- 4.61 (PC), whereas free was 65.5 +/- 17.6 ng/4 x 10(7) cells (n = 5 separate donors, mean +/- S.E.). Their generation was stimulated by triggering protease-activated receptors-1 and -4 and signaling via Ca(2+) mobilization secretory phospholipase A2, platelet-activating factor-acetylhydrolase, src tyrosine kinases, and protein kinase C. Stable isotope labeling showed that they form predominantly by esterification that occurs on the same time scale as free acid generation. Unlike free 12S-HETE that is secreted, esterified HETEs remain cell-associated, with HETE-PEs migrating to the outside of the plasma membrane. 12-Lipoxygenase inhibition attenuated externalization of native PE and phosphatidylserine and HETE-PEs. Platelets from a patient with the bleeding disorder, Scott syndrome, did not externalize HETE-PEs, and liposomes supplemented with HETE-PC dose-dependently enhanced tissue factor-dependent thrombin generation in vitro. This suggests a role for these novel lipids in promoting coagulation. Thus, oxidized phospholipids form by receptor/agonist mechanisms, not merely as an undesirable consequence of vascular and inflammatory disease.

Method for generating extreme ultraviolet with mather-type plasma accelerators for use in Extreme Ultraviolet Lithography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hassanein, Ahmed; Konkashbaev, Isak

A device and method for generating extremely short-wave ultraviolet electromagnetic wave uses two intersecting plasma beams generated by two plasma accelerators. The intersection of the two plasma beams emits electromagnetic radiation and in particular radiation in the extreme ultraviolet wavelength. In the preferred orientation two axially aligned counter streaming plasmas collide to produce an intense source of electromagnetic radiation at the 13.5 nm wavelength. The Mather type plasma accelerators can utilize tin, or lithium covered electrodes. Tin, lithium or xenon can be used as the photon emitting gas source.

Modelling of plasma generation and thin film deposition by a non-thermal plasma jet at atmospheric pressure

NASA Astrophysics Data System (ADS)

Sigeneger, F.; Becker, M. M.; Foest, R.; Loffhagen, D.

2016-09-01

The gas flow and plasma in a miniaturized non-thermal atmospheric pressure plasma jet for plasma enhanced chemical vapour deposition has been investigated by means of hydrodynamic modelling. The investigation focuses on the interplay between the plasma generation in the active zone where the power is supplied by an rf voltage to the filaments, the transport of active plasma particles due to the gas flow into the effluent, their reactions with the thin film precursor molecules and the transport of precursor fragments towards the substrate. The main features of the spatially two-dimensional model used are given. The results of the numerical modelling show that most active particles of the argon plasma are mainly confined within the active volume in the outer capillary of the plasma jet, with the exception of molecular argon ions which are transported remarkably into the effluent together with slow electrons. A simplified model of the precursor kinetics yields radial profiles of precursor fragment fluxes onto the substrate, which agree qualitatively with the measured profiles of thin films obtained by static film deposition experiments.

Role of plasma-induced defects in the generation of 1/f noise in graphene

NASA Astrophysics Data System (ADS)

Cultrera, Alessandro; Callegaro, Luca; Marzano, Martina; Ortolano, Massimo; Amato, Giampiero

2018-02-01

It has already been reported that 1/f noise in graphene can be dominated by fluctuations of charge carrier mobility. We show here that the increasing damage induced by oxygen plasma on graphene samples result in two trends: at low doses, the magnitude of the 1/f noise increases with the dose; and at high doses, it decreases with the dose. This behaviour is interpreted in the framework of 1/f noise generated by carrier mobility fluctuations where the concentration of mobility fluctuation centers and the mean free path of the carriers are competing factors.

Temperature and Nitric Oxide Generation in a Pulsed Arc Discharge Plasma

NASA Astrophysics Data System (ADS)

Namihira, T.; Sakai, S.; Matsuda, M.; D., Wang; Kiyan, T.; Akiyama, H.; Okamoto, K.; Toda, K.

2007-12-01

Nitric oxide (NO) is increasingly being used in medical treatments of high blood pressure, acute respiratory distress syndrome and other illnesses related to the lungs. Currently a NO inhalation system consists of a gas cylinder of N2 mixed with a high concentration of NO. This arrangement is potentially risky due to the possibility of an accidental leak of NO from the cylinder. The presence of NO in the air leads to the formation of nitric dioxide (NO2), which is toxic to the lungs. Therefore, an on-site generator of NO would be highly desirable for medical doctors to use with patients with lung disease. To develop the NO inhalation system without a gas cylinder, which would include a high concentration of NO, NAMIHIRA et al have recently reported on the production of NO from room air using a pulsed arc discharge. In the present work, the temperature of the pulsed arc discharge plasma used to generate NO was measured to optimize the discharge condition. The results of the temperature measurements showed the temperature of the pulsed arc discharge plasma reached about 10,000 K immediately after discharge initiation and gradually decreased over tens of microseconds. In addition, it was found that NO was formed in a discharge plasma having temperatures higher than 9,000 K and a smaller input energy into the discharge plasma generates NO more efficiently than a larger one.

Influence of plasma volume expansion with saline on the plasma levels of an ouabain-like factor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rauch, A.L.; Morris, M.; Buckalew, V.M. Jr.

1986-03-05

Plasma volume expansion with saline activates the cardiopulmonary baroreflex and causes the release of natriuretic factors(s). One putative natriuretic factor has ouabain-like activity (OLA). To examine the relationship between this factor and plasma volume expansion, the OLA of plasma was examined in rats that were volume expanded with 0.9% saline at a rate of 150..mu..l/min/100 g of rat for 15, 30, 60 and 120 minutes. Plasma OLA was quantitated with a radioreceptor assay utilizing /sup 3/H-ouabain and erythrocytes ghosts. The OLA and hematocrit of control rats were 18.2 +/- 2.93 pmoles of OLA/ml of plasma and 43.7 +/- 0.65. Aftermore » plasma volume expansion for 15 and 30 minutes, plasma OLA was not significantly altered (27.1 +/- 6.64 and 15.3 +/- 2.80, respectively). However, the hematocrit was reduced 13.9% (37.6 +/- 1.34, p < 0.05) and 33.6% (29.0 +/- 1.92, p < 0.01) for 15 and 30 minutes of volume expansion, respectively. After 60 minutes of volume expansion the hematocrit began to recover (33.7 +/- 2.16) although it was still significantly depressed (p < 0.01). At this time point the OLA was increased 248% to 63.4 +/- 22.7 pmoles of OLA/ml of plasma (p < 0.01). At 120 minutes of volume expansion the hematocrit was 38.3 +/- 1.24 and the OLA returned to control values (13.4 +/- 5.17). This data indicates that volume expansion causes an increase in plasma OLA and this increase in activity may contribute to the recovery of hematocrit that is seen with continued volume expansion.« less

Factor XIII as a modulator of plasma fibronectin alterations during experimental bacteremia.

PubMed

Kiener, J L; Cho, E; Saba, T M

1986-11-01

Fibronectin is found in plasma as well as in association with connective tissue and cell surfaces. Depletion of plasma fibronectin is often observed in septic trauma and burned patients, while experimental rats often manifest hyperfibronectinemia with sepsis. Since Factor XIII may influence the rate of clearance and deposition of plasma fibronectin into tissues, we evaluated the temporal changes in plasma fibronectin and plasma Factor XIII following bacteremia and RE blockade in rats in an attempt to understand the mechanism leading to elevation of fibronectin levels in bacteremic rats, which is distinct from that observed with RE blockade. Clearance of exogenously administered fibronectin after bacteremia was also determined. Rats received either saline, Pseudomonas aeruginosa (1 X 10(9) organisms), gelatinized RE test lipid emulsion (50 mg/100 gm B.W.), or emulsion followed by Pseudomonas. Plasma fibronectin and Factor XIII were determined at 0, 2, 24, and 48 hours post-blockade or bacteremia. At 24 and 48 hr following bacteremia alone or bacteremia after RE blockade, there was a significant elevation (p less than 0.05) of plasma fibronectin and a concomitant decrease (p less than 0.05) of plasma factor XIII activity. Extractable tissue fibronectin from liver and spleen was also increased at 24 and 48 hours following R.E. blockade plus bacteremia. In addition, the plasma clearance of human fibronectin was significantly prolonged (p less than 0.05) following bacterial challenge. Infusion of activated Factor XIII (20 units/rat) during a period of hyperfibronectinemia (908.0 +/- 55.1 micrograms/ml) resulted in a significant (p less than 0.05) decrease in plasma fibronectin (548.5 +/- 49.9 micrograms/ml) within 30 min. Thus Factor XIII deficiency in rats with bacteremia may contribute to the elevation in plasma fibronectin by altering kinetics associated with the clearance of fibronectin from the blood.

Frequency up-conversion of a high-power microwave pulse propagating in a self-generated plasma

NASA Technical Reports Server (NTRS)

Kuo, S. P.; Ren, A.

1992-01-01

In the study of the propagation of a high-power microwave pulse, one of the main concerns is how to minimize the energy loss of the pulse before reaching the destination. A frequency autoconversion process that can lead to reflectionless propagation of powerful electromagnetic pulses in self-generated plasmas is studied. The theory shows that, under the proper condition, the carrier frequency omega of the pulse shifts upward during the growth of local plasma frequency omega(pe). Thus, the self-generated plasma remains underdense to the pulse. A chamber experiment to demonstrate the frequency autoconversion during the pulse propagation through the self-generated plasma is conducted. The detected frequency shift is compared with the theoretical result calculated by using the measured electron density distribution along the propagation path of the pulse. Good agreement is obtained.

Second harmonic generation by self-focusing of intense hollow Gaussian laser beam in collisionless plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Purohit, Gunjan, E-mail: gunjan75@gmail.com; Rawat, Priyanka; Gauniyal, Rakhi

2016-01-15

The effect of self focused hollow Gaussian laser beam (HGLB) (carrying null intensity in center) on the excitation of electron plasma wave (EPW) and second harmonic generation (SHG) has been investigated in collisionless plasma, where relativistic-ponderomotive and only relativistic nonlinearities are operative. The relativistic change of electron mass and the modification of the background electron density due to ponderomotive nonlinearity lead to self-focusing of HGLB in plasma. Paraxial ray theory has been used to derive coupled equations for the self focusing of HGLB in plasma, generation of EPW, and second harmonic. These coupled equations are solved analytically and numerically tomore » study the laser intensity in the plasma, electric field associated with the excited EPW, and the power of SHG. Second harmonic emission is generated due to nonlinear coupling between incident HGLB and EPW satisfying the proper phase matching conditions. The results show that the effect of including the ponderomotive nonlinearity is significant on the generation of EPW and second harmonic. The electric field associated with EPW and the power of SHG are found to be highly sensitive to the order of the hollow Gaussian beam.« less

Power consumption analysis DBD plasma ozone generator

NASA Astrophysics Data System (ADS)

Nur, M.; Restiwijaya, M.; Muchlisin, Z.; Susan, I. A.; Arianto, F.; Widyanto, S. A.

2016-11-01

Studies on the consumption of energy by an ozone generator with various constructions electrodes of dielectric barrier discharge plasma (DBDP) reactor has been carried out. This research was done to get the configuration of the reactor, that is capable to produce high ozone concentrations with low energy consumption. BDBP reactors were constructed by spiral- cylindrical configuration, plasma ozone was generated by high voltage AC voltage up to 25 kV and maximum frequency of 23 kHz. The reactor consists of an active electrode in the form of a spiral-shaped with variation diameter Dc, and it was made by using copper wire with diameter Dw. In this research, we variated number of loops coil windings N as well as Dc and Dw. Ozone concentrations greater when the wire's diameter Dw and the diameter of the coil windings applied was greater. We found that impedance greater will minimize the concentration of ozone, in contrary to the greater capacitance will increase the concentration of ozone. The ozone concentrations increase with augmenting of power. Maximum power is effective at DBD reactor spiral-cylinder is on the Dc = 20 mm, Dw = 1.2 mm, and the number of coil windings N = 10 loops with the resulting concentration is greater than 20 ppm and it consumes energy of 177.60 watts

Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test – Demonstrated in vitro and ex vivo

PubMed Central

Madsen, Daniel Elenius; Nichols, Timothy C.; Merricks, Elizabeth P.; Waters, Emily K.; Wiinberg, Bo

2017-01-01

Introduction Canine models of severe haemophilia resemble their human equivalents both regarding clinical bleeding phenotype and response to treatment. Therefore pre-clinical studies in haemophilia dogs have allowed researchers to make valuable translational predictions regarding the potency and efficacy of new anti-haemophilia drugs (AHDs) in humans. To refine in vivo experiments and reduce number of animals, such translational studies are ideally preceded by in vitro prediction of compound efficacy using a plasma based global coagulation method. One such widely used method is the thrombin generation test (TGT). Unfortunately, commercially available TGTs are incapable of distinguishing between normal and haemophilia canine plasma, and therefore in vitro prediction using TGT has so far not been possible in canine plasma material. Aim Establish a modified TGT capable of: 1) distinguishing between normal and haemophilia canine plasma, 2) monitoring correlation between canine plasma levels of coagulation factor VIII (FVIII) and IX (FIX) and thrombin generation, 3) assessing for agreement between compound activity and thrombin generation in ex vivo samples. Methods A modified TGT assay was established where coagulation was triggered using a commercially available activated partial thromboplastin time reagent. Results With the modified TGT a significant difference was observed in thrombin generation between normal and haemophilia canine plasma. A dose dependent thrombin generation was observed when assessing haemophilia A and B plasma spiked with dilution series of FVIII and FIX, respectively. Correlation between FVIII activity and thrombin generation was observed when analyzing samples from haemophilia A dogs dosed with canine FVIII. Limit of detection was 0.1% (v/v) FVIII or FIX. Conclusion A novel modified TGT suitable for monitoring and prediction of replacement therapy efficacy in plasma from haemophilia A and B dogs was established. PMID:28384182

Simultaneous generation of acidic and alkaline water using atmospheric air plasma formed in water

NASA Astrophysics Data System (ADS)

Imai, Shin-ichi; Sakaguchi, Yoshihiro; Shirafuji, Tatsuru

2018-01-01

Plasmas on water surfaces and in water can be generated at atmosphere pressure using several kinds of gases, including helium, argon, oxygen, and air. Nitrates are generated in water through the interaction between water and atmospheric plasma that uses ambient air. Water that has been made acidic by the generation of nitric acid and the acidic water can be used for the sterilization of medical instruments, toilet bowls, and washing machines. Dishwashers are another potential application, as alkaline water is needed to remove grease from tableware. To investigate the production of alkaline water and its mechanism, gas component analysis was performed using an atmospheric quadrupole mass spectrometer. It was found that hydrogen gas evolves from the water surrounding both the positive and negative electrodes. The gas and water analyses carried out in this study revealed that acidic water of pH 2.5 and alkaline water of pH 10 can be simultaneously generated by our ambient air plasma device, which has been altered from our original model. The alterative plasma device has a partition wall, which is made of conductive resin, between the positive and negative electrodes.

Enhancement of plasma generation in catalyst pores with different shapes

NASA Astrophysics Data System (ADS)

Zhang, Yu-Ru; Neyts, Erik C.; Bogaerts, Annemie

2018-05-01

Plasma generation inside catalyst pores is of utmost importance for plasma catalysis, as the existence of plasma species inside the pores affects the active surface area of the catalyst available to the plasma species for catalytic reactions. In this paper, the electric field enhancement, and thus the plasma production inside catalyst pores with different pore shapes is studied with a two-dimensional fluid model. The results indicate that the electric field will be significantly enhanced near tip-like structures. In a conical pore with small opening, the strongest electric field appears at the opening and bottom corners of the pore, giving rise to a prominent ionization rate throughout the pore. For a cylindrical pore, the electric field is only enhanced at the bottom corners of the pore, with lower absolute value, and thus the ionization rate inside the pore is only slightly enhanced. Finally, in a conical pore with large opening, the electric field is characterized by a maximum at the bottom of the pore, yielding a similar behavior for the ionization rate. These results demonstrate that the shape of the pore has a significantly influence on the electric field enhancement, and thus modifies the plasma properties.

Magnetic field generation, Weibel-mediated collisionless shocks, and magnetic reconnection in colliding laser-produced plasmas

NASA Astrophysics Data System (ADS)

Fox, W.; Bhattacharjee, A.; Fiksel, G.

2016-10-01

Colliding plasmas are ubiquitous in astrophysical environments and allow conversion of kinetic energy into heat and, most importantly, the acceleration of particles to extremely high energies to form the cosmic ray spectrum. In collisionless astrophysical plasmas, kinetic plasma processes govern the interaction and particle acceleration processes, including shock formation, self-generation of magnetic fields by kinetic plasma instabilities, and magnetic field compression and reconnection. How each of these contribute to the observed spectra of cosmic rays is not fully understood, in particular both shock acceleration processes and magnetic reconnection have been proposed. We will review recent results of laboratory astrophysics experiments conducted at high-power, inertial-fusion-class laser facilities, which have uncovered significant results relevant to these processes. Recent experiments have now observed the long-sought Weibel instability between two interpenetrating high temperature plasma plumes, which has been proposed to generate the magnetic field necessary for shock formation in unmagnetized regimes. Secondly, magnetic reconnection has been studied in systems of colliding plasmas using either self-generated magnetic fields or externally applied magnetic fields, and show extremely fast reconnection rates, indicating fast destruction of magnetic energy and further possibilities to accelerate particles. Finally, we highlight kinetic plasma simulations, which have proven to be essential tools in the design and interpretation of these experiments.

Concentration of platelets and growth factors in platelet-rich plasma from Goettingen minipigs.

PubMed

Jungbluth, Pascal; Grassmann, Jan-Peter; Thelen, Simon; Wild, Michael; Sager, Martin; Windolf, Joachim; Hakimi, Mohssen

2014-01-01

In minipigs little is known about the concentration of growth factors in plasma, despite their major role in several patho-physiological processes such as healing of fractures. This prompted us to study the concentration of platelets and selected growth factors in plasma and platelet-rich plasma (PRP) preparation of sixteen Goettingen minipigs. Platelet concentrations increased significantly in PRP in comparison to native blood plasma. Generally, significant increase in the concentration of all growth factors tested was observed in the PRP in comparison to the corresponding plasma or serum. Five of the plasma samples examined contained detectable levels of bone morphogenic protein 2 (BMP-2) whereas eleven of the plasma or serum samples contained minimal amounts of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-bb) respectively. On the other hand variable concentrations of bone morphogenic protein 7 (BMP-7) and transforming growth factor β1 (TGF-β1) were measured in all plasma samples. In contrast, all PRP samples contained significantly increased amounts of growth factors. The level of BMP-2, BMP-7, TGF-β1, VEGF and PDGF-bb increased by 17.6, 1.5, 7.1, 7.2 and 103.3 fold, in comparison to the corresponding non-enriched preparations. Moreover significant positive correlations were found between platelet count and the concentrations of BMP-2 (r=0.62, p<0.001), TGF-β1 (r=0.85, p<0.001), VEGF (r=0.46, p<0.01) and PDGF-bb (r=0.9, p<0.001). Our results demonstrate that selected growth factors are present in the platelet-rich plasma of minipigs which might thus serve as a source of autologous growth factors.

Plasma zinc's alter ego is a low-molecular-weight humoral factor.

PubMed

Ou, Ou; Allen-Redpath, Keith; Urgast, Dagmar; Gordon, Margaret-Jane; Campbell, Gill; Feldmann, Jörg; Nixon, Graeme F; Mayer, Claus-Dieter; Kwun, In-Sook; Beattie, John H

2013-09-01

Mild dietary zinc deprivation in humans and rodents has little effect on blood plasma zinc levels, and yet cellular consequences of zinc depletion can be detected in vascular and other tissues. We proposed that a zinc-regulated humoral factor might mediate the effects of zinc deprivation. Using a novel approach, primary rat vascular smooth muscle cells (VSMCs) were treated with plasma from zinc-deficient (<1 mg Zn/kg) or zinc-adequate (35 mg Zn/kg, pair-fed) adult male rats, and zinc levels were manipulated to distinguish direct and indirect effects of plasma zinc. Gene expression changes were analyzed by microarray and qPCR, and incubation of VSMCs with blood plasma from zinc-deficient rats strongly changed the expression of >2500 genes, compared to incubation of cells with zinc-adequate rat plasma. We demonstrated that this effect was caused by a low-molecular-weight (∼2-kDa) zinc-regulated humoral factor but that changes in gene expression were mostly reversed by adding zinc back to zinc-deficient plasma. Strongly regulated genes were overrepresented in pathways associated with immune function and development. We conclude that zinc deficiency induces the production of a low-molecular-weight humoral factor whose influence on VSMC gene expression is blocked by plasma zinc. This factor is therefore under dual control by zinc.

Designing plasmas for chronic wound disinfection

NASA Astrophysics Data System (ADS)

Nosenko, T.; Shimizu, T.; Morfill, G. E.

2009-11-01

Irradiation with low-temperature atmospheric-pressure plasma provides a promising method for chronic wound disinfection. To be efficient for this purpose, plasma should meet the following criteria: it should significantly reduce bacterial density in the wounded area, cause a long-term post-irradiation inhibition of bacterial growth, yet without causing any negative effect on human cells. In order to design plasmas that would satisfy these requirements, we assessed the relative contribution of different components with respect to bactericidal properties due to irradiation with argon plasma. We demonstrate that plasma-generated UV radiation is the main short-term sterilizing factor of argon plasma. On the other hand, plasma-generated reactive nitrogen species (RNS) and reactive oxygen species (ROS) cause a long-term 'after-irradiation' inhibition of bacterial growth and, therefore, are important for preventing wound recolonization with bacteria between two treatments. We also demonstrate that at certain concentrations plasma-generated RNS and ROS cause significant reduction of bacterial density, but have no adverse effect on human skin cells. Possible mechanisms of the different effects of plasma-generated reactive species on bacteria and human cells are discussed. The results of this study suggest that argon plasma for therapeutic purposes should be optimized in the direction of reducing the intensity of plasma-generated UV radiation and increasing the density of non-UV plasma products.

Gas-pressure dependence of terahertz-pulse generation in a laser-generated nitrogen plasma

NASA Astrophysics Data System (ADS)

Löffler, T.; Roskos, H. G.

2002-03-01

Far-infrared (terahertz) pulses can be generated by photoionization of electrically biased gases with amplified laser pulses [T. Löffler, F. Jacob, and H. G. Roskos, Appl. Phys. Lett. 77, 453 (2000)]. The efficiency of the generation process can be significantly increased when the absolute gas pressure is raised because it is then possible to apply higher bias fields close to the dielectric breakdown field of the gas which increases with the pressure. The dependence of the THz output on the optical pump power does not show any indication of saturation, making the plasma emitter an interesting source for THz pulses especially in conjunction with terawatt laser systems.

Antiplatelet Agents Can Promote Two-Peaked Thrombin Generation in Platelet Rich Plasma: Mechanism and Possible Applications

PubMed Central

Tarandovskiy, Ivan D.; Artemenko, Elena O.; Panteleev, Mikhail A.; Sinauridze, Elena I.; Ataullakhanov, Fazoil I.

2013-01-01

Background Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions. In particular, TGC in platelet-rich plasma (PRP) can sometimes have two peaks. Objective We sought to understand the mechanism underlying the occurrence of two peaks in the PRP thrombin generation curve. Methods Tissue factor-induced thrombin generation in PRP and platelet-poor plasma (PPP) was monitored using continuous measurement of the hydrolysis rate of the thrombin-specific fluorogenic substrate Z-Gly-Gly-Arg-AMC. Expression of phosphatidylserine (PS) and CD62P on the surface of activated platelets was measured by flow cytometry using corresponding fluorescently labeled markers. Results The addition of the P2Y12 receptor antagonist MeS-AMP (160 µM), 83 nM prostaglandin E1 (PGE1), or 1.6% DMSO to PRP caused the appearance of two peaks in the TGC. The PS exposure after thrombin activation on washed platelets in a suspension supplemented with DMSO, PGE1 or MeS-AMP was delayed, which could indicate mechanism of the second peak formation. Supplementation of PRP with 1.6% DMSO plus 830 nM PGE1 mediated the disappearance of the second peak and decreased the amplitude of the first peak. Increasing the platelet concentration in the PRP promoted the consolidation of the two peaks into one. Conclusions Procoagulant tenase and prothrombinase complexes in PRP assemble on phospholipid surfaces containing PS of two types - plasma lipoproteins and the surface of activated platelets. Thrombin generation in the PRP can be two-peaked. The second peak appears in the presence of platelet antagonists as a result of delayed PS expression on platelets, which leads to delayed assembly of the membrane-dependent procoagulant complexes and a second wave of thrombin generation. PMID:23405196

Bright high-order harmonic generation with controllable polarization from a relativistic plasma mirror

PubMed Central

Chen, Zi-Yu; Pukhov, Alexander

2016-01-01

Ultrafast extreme ultraviolet (XUV) sources with a controllable polarization state are powerful tools for investigating the structural and electronic as well as the magnetic properties of materials. However, such light sources are still limited to only a few free-electron laser facilities and, very recently, to high-order harmonic generation from noble gases. Here we propose and numerically demonstrate a laser–plasma scheme to generate bright XUV pulses with fully controlled polarization. In this scheme, an elliptically polarized laser pulse is obliquely incident on a plasma surface, and the reflected radiation contains pulse trains and isolated circularly or highly elliptically polarized attosecond XUV pulses. The harmonic polarization state is fully controlled by the laser–plasma parameters. The mechanism can be explained within the relativistically oscillating mirror model. This scheme opens a practical and promising route to generate bright attosecond XUV pulses with desirable ellipticities in a straightforward and efficient way for a number of applications. PMID:27531047

Influence of the RF electrode cleanliness on plasma characteristics and dust-particle generation in methane dusty plasmas

NASA Astrophysics Data System (ADS)

Géraud-Grenier, I.; Desdions, W.; Faubert, F.; Mikikian, M.; Massereau-Guilbaud, V.

2018-01-01

The methane decomposition in a planar RF discharge (13.56 MHz) leads both to a dust-particle generation in the plasma bulk and to a coating growth on the electrodes. Growing dust-particles fall onto the grounded electrode when they are too heavy. Thus, at the end of the experiment, the grounded electrode is covered by a coating and by fallen dust-particles. During the dust-particle growth, the negative DC self-bias voltage (VDC) increases because fewer electrons reach the RF electrode, leading to a more resistive plasma and to changes in the plasma chemical composition. In this paper, the cleanliness influence of the RF electrode on the dust-particle growth, on the plasma characteristics and composition is investigated. A cleanliness electrode is an electrode without coating and dust-particles on its surface at the beginning of the experiment.

Efficacy of solvent/detergent plasma after storage at 2-8 °C for 5 days in comparison to other plasma products to improve factor V levels in factor V deficient plasma.

PubMed

Cushing, Melissa M; Asmis, Lars; Calabia, Carmencita; Rand, Jacob H; Haas, Thorsten

2016-08-01

Factor V (FV) plays an important role in coagulation. As no purified concentrate is available to restore critical FV levels, the main blood product used to replace FV is plasma. The aim of the present in vitro study was to compare the efficacy of the different available plasma products on the reversal of moderate and severe FV deficiency as assessed by ROTEM® and FV levels. Five different plasma products (6 batches of each) were compared to determine their effectiveness in replacing FV in plasma moderately or severely deficient in FV. Effectiveness was measured using the ROTEM® EXTEM clotting time (CT) and a factor V assay. FFP, plasma frozen within 24 hours (FP24), Octaplas (solvent/detergent treated pooled plasma), as well as Octaplas and FP24 thawed and stored for 5 days (Octaplas TP and TP), were all used for in vitro replacement of FV. TP was significantly less effective at reversing a prolonged EXTEM CT and FV levels in FV deficient plasma than other tested products. There were no significant differences in EXTEM CT between Octaplas and Octaplas TP, while factor V activity was significantly lower in the Octaplas TP. There was no significant difference between Octaplas and FFP for EXTEM CT or FV activity. Octaplas and Octaplas TP appear to have an equivalent ability to improve the EXTEM CT and could be considered as a treatment alternative to FFP in patients with FV deficiency. Copyright © 2016 Elsevier Ltd. All rights reserved.

Dimensionless factors for an alternating-current non-thermal arc plasma

NASA Astrophysics Data System (ADS)

Zhang, Si-Yuan; Li, Xiao-Song; Liu, Jin-Bao; Liu, Jing-Lin; Li, He-Ping; Zhu, Ai-Min

2016-12-01

A gliding arc discharge, as a source of warm plasma combining advantages of both thermal and cold plasmas, would have promising application prospects in the fields of fuel conversion, combustion enhancement, material synthesis, surface modifications, pollution control, etc. In order to gain insight into the features of an alternating-current gliding arc discharge plasma, three dimensionless factors, i.e., the extinction span (ψ), current lag (δ), and heating lag (χ) factors are proposed in this letter based on the measured waveforms of the discharge voltage and current in an AC gliding arc discharge plasma. The influences of the driving frequency of the power supply (f) on these three dimensionless parameters are investigated experimentally with the explanations on the physical meanings of these factors. The experimental results show that a higher value of f would lead to the lower values of ψ and δ, as well as a higher value of χ. These experimental phenomena indicate a lower threshold ignition voltage of the discharges, a lower current-growth inertia of the gliding arcs and a larger relative thermal inertia of the plasmas with increase the driving frequency of the power supply in the operating parameter range studied in this letter.

Electron dynamics in high energy density plasma bunch generation driven by intense picosecond laser pulse

NASA Astrophysics Data System (ADS)

Li, M.; Yuan, T.; Xu, Y. X.; Luo, S. N.

2018-05-01

When an intense picosecond laser pulse is loaded upon a dense plasma, a high energy density plasma bunch, including electron bunch and ion bunch, can be generated in the target. We simulate this process through one-dimensional particle-in-cell simulation and find that the electron bunch generation is mainly due to a local high energy density electron sphere originated in the plasma skin layer. Once generated the sphere rapidly expands to compress the surrounding electrons and induce high density electron layer, coupled with that, hot electrons are efficiently triggered in the local sphere and traveling in the whole target. Under the compressions of light pressure, forward-running and backward-running hot electrons, a high energy density electron bunch generates. The bunch energy density is as high as TJ/m3 order of magnitude in our conditions, which is significant in laser driven dynamic high pressure generation and may find applications in high energy density physics.

Ultra-low emittance electron beam generation using ionization injection in a plasma beatwave accelerator

NASA Astrophysics Data System (ADS)

Schroeder, Carl; Benedetti, Carlo; Esarey, Eric; Leemans, Wim

2017-10-01

Ultra-low emittance beams can be generated using ionization injection of electrons into a wakefield excited by a plasma beatwave accelerator. This all-optical method of electron beam generation uses three laser pulses of different colors. Two long-wavelength laser pulses, with frequency difference equal to the plasma frequency, resonantly drive a plasma wave without fully ionizing a gas. A short-wavelength injection laser pulse (with a small ponderomotive force and large peak electric field), co-propagating and delayed with respect to the beating long-wavelength lasers, ionizes a fraction of the remaining bound electrons at a trapped wake phase, generating an electron beam that is accelerated in the wakefield. Using the beating of long-wavelength pulses to generate the wakefield enables atomically-bound electrons to remain at low ionization potentials, reducing the required amplitude of the ionization pulse, and, hence, the initial transverse momentum and emittance of the injected electrons. An example is presented using two lines of a CO2 laser to form a plasma beatwave accelerator to drive the wake and a frequency-doubled Ti:Al2O3 laser for ionization injection. Supported by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.

Low- and high-order harmonic generation in the extended plasmas produced by laser ablation of zinc and manganese targets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ganeev, R. A., E-mail: rashid-ganeev@mail.ru; Physical Department, Voronezh State University, Voronezh 394006; Baba, M.

The systematic studies of the harmonic generation of ultrashort laser pulses in the 5-mm-long Zn and Mn plasmas (i.e., application of nanosecond, picosecond, and femtosecond pulses for ablation, comparison of harmonic generation from atomic, ionic, and cluster-contained species of plasma, variation of plasma length, two-color pump of plasmas, etc.) are presented. The conversion efficiency of the 11th–19th harmonics generated in the Zn plasma was ∼5 × 10{sup −5}. The role of the ionic resonances of Zn near the 9th and 10th harmonics on the enhancement of harmonics is discussed. The enhancement of harmonics was also analyzed using the two-color pump of extendedmore » plasmas, which showed similar intensities of the odd and even harmonics along the whole range of generation. The harmonics up to the 107th order were demonstrated in the case of manganese plasma. The comparison of harmonic generation in the 5-mm-long and commonly used short (≤0.5 mm) plasma plumes showed the advanced properties of extended media.« less

A study of increasing radical density and etch rate using remote plasma generator system

NASA Astrophysics Data System (ADS)

Lee, Jaewon; Kim, Kyunghyun; Cho, Sung-Won; Chung, Chin-Wook

2013-09-01

To improve radical density without changing electron temperature, remote plasma generator (RPG) is applied. Multistep dissociation of the polyatomic molecule was performed using RPG system. RPG is installed to inductively coupled type processing reactor; electrons, positive ions, radicals and polyatomic molecule generated in RPG and they diffused to processing reactor. The processing reactor dissociates the polyatomic molecules with inductively coupled power. The polyatomic molecules are dissociated by the processing reactor that is operated by inductively coupled power. Therefore, the multistep dissociation system generates more radicals than single-step system. The RPG was composed with two cylinder type inductively coupled plasma (ICP) using 400 kHz RF power and nitrogen gas. The processing reactor composed with two turn antenna with 13.56 MHz RF power. Plasma density, electron temperature and radical density were measured with electrical probe and optical methods.

The dynamics of a surface plasma generated by an independent source in the field of laser emission

NASA Astrophysics Data System (ADS)

Kovalev, A. S.; Popov, A. M.; Seleznev, B. V.; Feoktistov, V. A.

1986-09-01

A study is made of the evolution of a plasma formation generated by a high-power short pulse of an Nd laser on a metal surface, with the relatively weak emission of a CO2 laser focused on the surface. The thresholds of a sustained breakdown plasma are measured as a function of the plasma-generating pulse energy. The dynamics of plasma front propagation along the target surface and in the direction opposite to the laser beam direction is investigated. It is shown that the use of an additional laser with an energy less than that of the CO2 laser by 2-3 orders of magnitude makes it possible to generate a surface plasma capable of absorbing and transferring to the target a significantly greater fraction of the CO2 laser energy.

Schlieren Technique Applied to Magnetohydrodynamic Generator Plasma Torch

NASA Astrophysics Data System (ADS)

Chopra, Nirbhav; Pearcy, Jacob; Jaworski, Michael

2017-10-01

Magnetohydrodynamic (MHD) generators are a promising augmentation to current hydrocarbon based combustion schemes for creating electrical power. In recent years, interest in MHD generators has been revitalized due to advances in a number of technologies such as superconducting magnets, solid-state power electronics and materials science as well as changing economics associated with carbon capture, utilization, and sequestration. We use a multi-wavelength schlieren imaging system to evaluate electron density independently of gas density in a plasma torch under conditions relevant to MHD generators. The sensitivity and resolution of the optical system are evaluated alongside the development of an automated analysis and calibration program in Python. Preliminary analysis shows spatial resolutions less than 1mm and measures an electron density of ne = 1 ×1016 cm-3 in an atmospheric microwave torch. Work supported by DOE contract DE-AC02-09CH11466.

A Multiple Z-Pinch Configuration for the Generation of High-Density, Magnetized Plasmas

NASA Astrophysics Data System (ADS)

Tarditi, Alfonso G.

2015-11-01

The z-pinch is arguably the most straightforward and economical approach for the generation and confinement of hot plasmas, with a long history of theoretical investigations and experimental developments. While most of the past studies were focused on countering the natural tendency of z-pinches to develop instabilities, this study attempts to take advantage of those unstable regimes to form a quasi-stable plasma, with higher density and temperature, possibly of interest for a fusion reactor concept. For this purpose, a configuration with four z-pinch discharges, with axis parallel to each other and symmetrically positioned, is considered. Electrodes for the generation of the discharges and magnetic coils are arranged to favor the formation of concave discharge patterns. The mutual attraction from the co-streaming discharge currents enhances this pattern, leading to bent plasma streams, all nearing towards the axis. This configuration is intended to excite and sustain a ``kink'' unstable mode for each z-pinch, eventually producing either plasmoid structures, detached from each discharge, or sustained kink patterns: both these cases appear to lead to plasmas merging in the central region. The feasibility of this approach in creating a higher density, hotter, meta-stable plasma regime is investigated computationally, addressing both the kink excitation phase and the dynamics of the converging plasma columns.

Laser-plasma mirrors: from electron acceleration to harmonics generation

NASA Astrophysics Data System (ADS)

Thévenet, Maxence; Bocoum, Maïmouna; Faure, Jérôme; Leblanc, Adrien; Vincenti, Henri; Quéré, Fabien

2016-10-01

Accelerating electrons in the > 10 TV/m fields inside an ultrashort ultraintense laser pulse has been a long-standing goal in experimental physics, motivated by promising theoretical predictions. The biggest hurdle was to have electrons injected in the center of the laser pulse. Recent experimental and numerical results showed that this problem could be solved using a plasma mirror, i.e. an overdense plasma with a sharp (generation mechanisms on plasma mirrors, giving new insights into the motion of the plasma mirror surface. funded by the European Research Council, Contract No. 306708, ERC Starting Grant FEMTOELEC.

Influence of impact conditions on plasma generation during hypervelocity impact by aluminum projectile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Song, Weidong, E-mail: swdgh@bit.edu.cn; Lv, Yangtao; Li, Jianqiao

2016-07-15

For describing hypervelocity impact (relative low-speed as related to space debris and much lower than travelling speed of meteoroids) phenomenon associated with plasma generation, a self-developed 3D code was advanced to numerically simulate projectiles impacting on a rigid wall. The numerical results were combined with a new ionization model which was developed in an early study to calculate the ionized materials during the impact. The calculated results of ionization were compared with the empirical formulas concluded by experiments in references and a good agreement was obtained. Then based on the reliable 3D numerical code, a series of impacts with differentmore » projectile configurations were simulated to investigate the influence of impact conditions on hypervelocity impact generated plasma. It was found that the form of empirical formula needed to be modified. A new empirical formula with a critical impact velocity was advanced to describe the velocity dependence of plasma generation and the parameters of the modified formula were ensured by the comparison between the numerical predictions and the empirical formulas. For different projectile configurations, the changes of plasma charges with time are different but the integrals of charges on time almost stayed in the same level.« less

Generation of electromagnetic emission during the injection of dense supersonic plasma flows into arched magnetic field

NASA Astrophysics Data System (ADS)

Viktorov, Mikhail; Golubev, Sergey; Mansfeld, Dmitry; Vodopyanov, Alexander

2016-04-01

Interaction of dense supersonic plasma flows with an inhomogeneous arched magnetic field is one of the key problems in near-Earth and space plasma physics. It can influence on the energetic electron population formation in magnetosphere of the Earth, movement of plasma flows in magnetospheres of planets, energy release during magnetic reconnection, generation of electromagnetic radiation and particle precipitation during solar flares eruption. Laboratory study of this interaction is of big interest to determine the physical mechanisms of processes in space plasmas and their detailed investigation under reproducible conditions. In this work a new experimental approach is suggested to study interaction of supersonic (ion Mach number up to 2.7) dense (up to 1015 cm-3) plasma flows with inhomogeneous magnetic field (an arched magnetic trap with a field strength up to 3.3 T) which opens wide opportunities to model space plasma processes in laboratory conditions. Fully ionized plasma flows with density from 1013 cm-3 to 1015 cm-3 are created by plasma generator on the basis of pulsed vacuum arc discharge. Then plasma is injected in an arched open magnetic trap along or across magnetic field lines. The filling of the arched magnetic trap with dense plasma and further magnetic field lines break by dense plasma flow were experimentally demonstrated. The process of plasma deceleration during the injection of plasma flow across the magnetic field lines was experimentally demonstrated. Pulsed plasma microwave emission at the electron cyclotron frequency range was observed. It was shown that frequency spectrum of plasma emission is determined by position of deceleration region in the magnetic field of the magnetic arc, and is affected by plasma density. Frequency spectrum shifts to higher frequencies with increasing of arc current (plasma density) because the deceleration region of plasma flow moves into higher magnetic field. The observed emission can be related to the

Laser propagation and soliton generation in strongly magnetized plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, W.; Li, J. Q.; Kishimoto, Y.

The propagation characteristics of various laser modes with different polarization, as well as the soliton generation in strongly magnetized plasmas are studied numerically through one-dimensional (1D) particle-in-cell (PIC) simulations and analytically by solving the laser wave equation. PIC simulations show that the laser heating efficiency substantially depends on the magnetic field strength, the propagation modes of the laser pulse and their intensities. Generally, large amplitude laser can efficiently heat the plasma with strong magnetic field. Theoretical analyses on the linear propagation of the laser pulse in both under-dense and over-dense magnetized plasmas are well confirmed by the numerical observations. Mostmore » interestingly, it is found that a standing or moving soliton with frequency lower than the laser frequency is generated in certain magnetic field strength and laser intensity range, which can greatly enhance the laser heating efficiency. The range of magnetic field strength for the right-hand circularly polarized (RCP) soliton formation with high and low frequencies is identified by solving the soliton equations including the contribution of ion's motion and the finite temperature effects under the quasi-neutral approximation. In the limit of immobile ions, the RCP soliton tends to be peaked and stronger as the magnetic field increases, while the enhanced soliton becomes broader as the temperature increases. These findings in 1D model are well validated by 2D simulations.« less

Decreased Plasma Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Concentrations during Military Training

PubMed Central

Nibuya, Masashi; Ishida, Toru; Yamamoto, Tetsuo; Mukai, Yasuo; Mitani, Keiji; Tsumatori, Gentaro; Scott, Daniel; Shimizu, Kunio

2014-01-01

Decreased concentrations of plasma brain-derived neurotrophic factor (BDNF) and serum BDNF have been proposed to be a state marker of depression and a biological indicator of loaded psychosocial stress. Stress evaluations of participants in military mission are critically important and appropriate objective biological parameters that evaluate stress are needed. In military circumstances, there are several problems to adopt plasma BDNF concentration as a stress biomarker. First, in addition to psychosocial stress, military missions inevitably involve physical exercise that increases plasma BDNF concentrations. Second, most participants in the mission do not have adequate quality or quantity of sleep, and sleep deprivation has also been reported to increase plasma BDNF concentration. We evaluated plasma BDNF concentrations in 52 participants on a 9-week military mission. The present study revealed that plasma BDNF concentration significantly decreased despite elevated serum enzymes that escaped from muscle and decreased quantity and quality of sleep, as detected by a wearable watch-type sensor. In addition, we observed a significant decrease in plasma vascular endothelial growth factor (VEGF) during the mission. VEGF is also neurotrophic and its expression in the brain has been reported to be up-regulated by antidepressive treatments and down-regulated by stress. This is the first report of decreased plasma VEGF concentrations by stress. We conclude that decreased plasma concentrations of neurotrophins can be candidates for mental stress indicators in actual stressful environments that include physical exercise and limited sleep. PMID:24586790

Non-ambipolar radio-frequency plasma electron source and systems and methods for generating electron beams

DOEpatents

Hershkowitz, Noah [Madison, WI; Longmier, Benjamin [Madison, WI; Baalrud, Scott [Madison, WI

2009-03-03

An electron generating device extracts electrons, through an electron sheath, from plasma produced using RF fields. The electron sheath is located near a grounded ring at one end of a negatively biased conducting surface, which is normally a cylinder. Extracted electrons pass through the grounded ring in the presence of a steady state axial magnetic field. Sufficiently large magnetic fields and/or RF power into the plasma allow for helicon plasma generation. The ion loss area is sufficiently large compared to the electron loss area to allow for total non-ambipolar extraction of all electrons leaving the plasma. Voids in the negatively-biased conducting surface allow the time-varying magnetic fields provided by the antenna to inductively couple to the plasma within the conducting surface. The conducting surface acts as a Faraday shield, which reduces any time-varying electric fields from entering the conductive surface, i.e. blocks capacitive coupling between the antenna and the plasma.

Non-ambipolar radio-frequency plasma electron source and systems and methods for generating electron beams

NASA Technical Reports Server (NTRS)

Hershkowitz, Noah (Inventor); Longmier, Benjamin (Inventor); Baalrud, Scott (Inventor)

2011-01-01

An electron generating device extracts electrons, through an electron sheath, from plasma produced using RF fields. The electron sheath is located near a grounded ring at one end of a negatively biased conducting surface, which is normally a cylinder. Extracted electrons pass through the grounded ring in the presence of a steady state axial magnetic field. Sufficiently large magnetic fields and/or RF power into the plasma allow for helicon plasma generation. The ion loss area is sufficiently large compared to the electron loss area to allow for total non-ambipolar extraction of all electrons leaving the plasma. Voids in the negatively-biased conducting surface allow the time-varying magnetic fields provided by the antenna to inductively couple to the plasma within the conducting surface. The conducting surface acts as a Faraday shield, which reduces any time-varying electric fields from entering the conductive surface, i.e. blocks capacitive coupling between the antenna and the plasma.

Non-ambipolar radio-frequency plasma electron source and systems and methods for generating electron beams

NASA Technical Reports Server (NTRS)

Hershkowitz, Noah (Inventor); Longmier, Benjamin (Inventor); Baalrud, Scott (Inventor)

2009-01-01

An electron generating device extracts electrons, through an electron sheath, from plasma produced using RF fields. The electron sheath is located near a grounded ring at one end of a negatively biased conducting surface, which is normally a cylinder. Extracted electrons pass through the grounded ring in the presence of a steady state axial magnetic field. Sufficiently large magnetic fields and/or RF power into the plasma allow for helicon plasma generation. The ion loss area is sufficiently large compared to the electron loss area to allow for total non-ambipolar extraction of all electrons leaving the plasma. Voids in the negatively-biased conducting surface allow the time-varying magnetic fields provided by the antenna to inductively couple to the plasma within the conducting surface. The conducting surface acts as a Faraday shield, which reduces any time-varying electric fields from entering the conductive surface, i.e. blocks capacitive coupling between the antenna and the plasma.

An Explorative Study to Use DBD Plasma Generation for Aircraft Icing Mitigation

NASA Astrophysics Data System (ADS)

Hu, Hui; Zhou, Wenwu; Liu, Yang; Kolbakir, Cem

2017-11-01

An explorative investigation was performed to demonstrate the feasibility of utilizing thermal effect induced by Dielectric-Barrier-Discharge (DBD) plasma generation for aircraft icing mitigation. The experimental study was performed in an Icing Research Tunnel available at Iowa State University (i.e., ISU-IRT). A NACA0012 airfoil/wing model embedded with DBD plasma actuators was installed in ISU-IRT under typical glaze icing conditions pertinent to aircraft inflight icing phenomena. While a high-speed imaging system was used to record the dynamic ice accretion process over the airfoil surface for the test cases with and without switching on the DBD plasma actuators, an infrared (IR) thermal imaging system was utilized to map the corresponding temperature distributions to quantify the unsteady heat transfer and phase changing process over the airfoil surface. The thermal effect induced by DBD plasma generation was demonstrated to be able to keep the airfoil surface staying free of ice during the entire ice accretion experiment. The measured quantitative surface temperature distributions were correlated with the acquired images of the dynamic ice accretion and water runback processes to elucidate the underlying physics. National Science Foundation CBET-1064196 and CBET-1435590.

PREFACE: Acceleration and radiation generation in space and laboratory plasmas

NASA Astrophysics Data System (ADS)

Bingham, R.; Katsouleas, T.; Dawson, J. M.; Stenflo, L.

1994-01-01

Sixty-six leading researchers from ten nations gathered in the Homeric village of Kardamyli, on the southern coast of mainland Greece, from August 29-September 4, 1993 for the International Workshop on Acceleration and Radiation Generation in Space and Laboratory Plasmas. This Special Issue represents a cross-section of the presentations made at and the research stimulated by that meeting. According to the Iliad, King Agamemnon used Kardamyli as a dowry offering in order to draw a sulking Achilles into the Trojan War. 3000 years later, Kardamyli is no less seductive. Its remoteness and tranquility made it an ideal venue for promoting the free exchange of ideas between various disciplines that do not normally interact. Through invited presen tations, informal poster discussions and working group sessions, the Workshop brought together leaders from the laboratory and space/astrophysics communities working on common problems of acceleration and radiation generation in plasmas. It was clear from the presentation and discussion sessions that there is a great deal of common ground between these disciplines which is not at first obvious due to the differing terminologies and types of observations available to each community. All of the papers in this Special Issue highlight the role collective plasma processes play in accelerating particles or generating radiation. Some are state-of-the-art presentations of the latest research in a single discipline, while others investi gate the applicability of known laboratory mechanisms to explain observations in natural plasmas. Notable among the latter are the papers by Marshall et al. on kHz radiation in the magnetosphere ; Barletta et al. on collective acceleration in solar flares; and by Dendy et al. on ion cyclotron emission. The papers in this Issue are organized as follows: In Section 1 are four general papers by Dawson, Galeev, Bingham et al. and Mon which serves as an introduction to the physical mechanisms of acceleration

EFFECTS OF LASER RADIATION ON MATTER. LASER PLASMA: Low-threshold generation of harmonics and hard x radiation in a laser plasma. 2. Multipeak generation

NASA Astrophysics Data System (ADS)

Apollonov, V. V.; Derzhavin, S. I.; Kazakov, K. Kh

1993-02-01

The conditions for the generation of hard x radiation with a multipeak structure in a plasma pumped by a long pulse from a free-running CO2 laser at a low intensity (q≲10 GW/cm2) have been studied. This x-ray generation had been observed in a previous study by the present authors. It is shown that this generation of hard x radiation with a multipeak structure leads to a more than tenfold increase in the yield of hard x radiation per laser pulse, under optimum conditions. This increase results from the additional peaks in the x-ray signal. An explanation of this effect is proposed.

Third harmonic generation of a short pulse laser in a plasma density ripple created by a machining beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, C. S.; Tripathi, V. K.

An intense machining laser beam, impinged on a gas jet target, causes space periodic ionization of the gas and heats the electrons. The nonuniform plasma pressure leads to atomic density redistribution. When, after a suitable time delay, a second more intense laser pulse is launched along the periodicity wave vector q-vector, a plasma density ripple n{sub q} is instantly created, leading to resonant third harmonic generation when q=4{omega}{sub p}{sup 2}/(3{omega}c{gamma}{sub 0}), where {omega}{sub p} is the plasma frequency, {omega} is the laser frequency, and {gamma}{sub 0} is the electron Lorentz factor. The third harmonic is produced through the beating ofmore » ponderomotive force induced second harmonic density oscillations and the quiver velocity of electrons at the fundamental. The relativistic mass nonlinearity plays no role in resonant coupling. The energy conversion efficiency scales as the square of plasma density and square of depth of density ripple, and is {approx}0.2% for normalized laser amplitude a{sub o}{approx}1 in a plasma of 1% critical density with 20% density ripple. The theory explains several features of a recent experiment.« less

Probing plasma wakefields using electron bunches generated from a laser wakefield accelerator

NASA Astrophysics Data System (ADS)

Zhang, C. J.; Wan, Y.; Guo, B.; Hua, J. F.; Pai, C.-H.; Li, F.; Zhang, J.; Ma, Y.; Wu, Y. P.; Xu, X. L.; Mori, W. B.; Chu, H.-H.; Wang, J.; Lu, W.; Joshi, C.

2018-04-01

We show experimental results of probing the electric field structure of plasma wakes by using femtosecond relativistic electron bunches generated from a laser wakefield accelerator. Snapshots of laser-driven linear wakes in plasmas with different densities and density gradients are captured. The spatiotemporal evolution of the wake in a plasma density up-ramp is recorded. Two parallel wakes driven by a laser with a main spot and sidelobes are identified in the experiment and reproduced in simulations. The capability of this new method for capturing the electron- and positron-driven wakes is also shown via 3D particle-in-cell simulations.

Optical Analysis Of The Vacuum Arc Plasma Generated In Cup-Shape Contacts

NASA Astrophysics Data System (ADS)

Pavelescu, G.; Pavelescu, D.; Dumitrescu, G.; Anghelita, P.; Gherendi, F.

2007-04-01

In this paper are presented the results of the optical analysis on the rotating arc plasma, generated in the vacuum low voltage circuit breaker with cup-shaped contacts. An adequate experimental setup was used for single shot time and spatial resolved spectroscopy in order to analyze the evolution of the vacuum arc plasma. Different current interruption situations are correlated with plasma spectral diagnosis. The study is aimed to contribute to a better understanding of the complex phenomena that take place in the interruption process of high currents that appears in the short-circuit regime of electrical networks.

A simulation study of interactions of space-shuttle generated electron beams with ambient plasma and neutral gas

NASA Technical Reports Server (NTRS)

Winglee, Robert M.

1991-01-01

The objective was to conduct large scale simulations of electron beams injected into space. The study of the active injection of electron beams from spacecraft is important, as it provides valuable insight into the plasma beam interactions and the development of current systems in the ionosphere. However, the beam injection itself is not simple, being constrained by the ability of the spacecraft to draw current from the ambient plasma. The generation of these return currents is dependent on several factors, including the density of the ambient plasma relative to the beam density, the presence of neutrals around the spacecraft, the configuration of the spacecraft, and the motion of the spacecraft through the plasma. Two dimensional (three velocity) particle simulations with collisional processes included are used to show how these different and often coupled processes can be used to enhance beam propagation from the spacecraft. To understand the radial expansion mechanism of an electron beam injected from a highly charged spacecraft, two dimensional particle-in-cell simulations were conducted for a high density electron beam injected parallel to magnetic fields from an isolated equipotential conductor into a cold background plasma. The simulations indicate that charge build-up at the beam stagnation point causes the beam to expand radially to the beam electron gyroradius.

A simulation study of interactions of Space-Shuttle generated electron beams with ambient plasma and neutral gas

NASA Technical Reports Server (NTRS)

1991-01-01

The object was to conduct large scale simulations of electron beams injected into space. The study of active injection of electron beams from spacecraft is important since it provides valuable insight into beam-plasma interactions and the development of current systems in the ionosphere. However, the beam injection itself is not simple, being constrained by the ability of the spacecraft to draw return current from the ambient plasma. The generation of these return currents is dependent on several factors, including the density of the ambient plasma relative to the beam density, the presence of neutrals around the spacecraft, the configuration of the spacecraft, and the motion of the spacecraft through the plasma. Two dimensional particle simulations with collisional processes included are used to show how these different and often coupled processes can be utilized to enhance beam propagation from the spacecraft. To understand the radical expansion of mechanism of an electron beam from a highly charged spacecraft, two dimensional particle in cell simulations were conducted for a high density electron beam injected parallel to magnetic fields from an isolated equipotential conductor into a cold background plasma. The simulations indicate that charge buildup at the beam stagnation point causes the beam to expand radially to the beam electron gyroradius.

Solar Wind Strahl Broadening by Self-Generated Plasma Waves

NASA Technical Reports Server (NTRS)

Pavan, J.; Vinas, A. F.; Yoon, P. H.; Ziebell, L. F.; Gaelzer, R.

2013-01-01

This Letter reports on the results of numerical simulations which may provide a possible explanation for the strahl broadening during quiet solar conditions. The relevant processes involved in the broadening are due to kinetic quasi-linear wave-particle interaction. Making use of static analytical electron distribution in an inhomogeneous field, it is found that self-generated electrostatic waves at the plasma frequency, i.e., Langmuir waves, are capable of scattering the strahl component, resulting in energy and pitch-angle diffusion that broadens its velocity distribution significantly. The present theoretical results provide an alternative or complementary explanation to the usual whistler diffusion scenario, suggesting that self-induced electrostatic waves at the plasma frequency might play a key role in broadening the solar wind strahl during quiet solar conditions.

A spectral study of a radio-frequency plasma-generated flux of atomic oxygen

NASA Technical Reports Server (NTRS)

Batten, Carmen E.; Brown, Kenneth G.; Lewis, Beverley W.

1994-01-01

The active environment of a radio-frequency (RF) plasma generator, with and without low-pressure oxygen, has been characterized through the identification of emission lines in the spectral region from 250 to 900 nm. The environment is shown to be dependent on the partial pressure of oxygen and the power applied to the RF generator. Atomic oxygen has been found in significant amounts as well as atomic hydrogen and the molecular oxygen species O2((sup 1)Sigma). The only charged species observed was the singly charged molecular ion O2(+). With a polymer specimen in the plasma chamber, carbon monoxide was also observed. The significance of these observations with respect to previous studies using this type of generator to stimulate material degradation in space is discussed. The possibility of using these generators as atomic oxygen sources in the development of oxygen atom fluorescence sensors is explored.

Generation of terahertz radiation by intense hollow Gaussian laser beam in magnetised plasma under relativistic-ponderomotive regime

NASA Astrophysics Data System (ADS)

Rawat, Priyanka; Rawat, Vinod; Gaur, Bineet; Purohit, Gunjan

2017-07-01

This paper explores the self-focusing of hollow Gaussian laser beam (HGLB) in collisionless magnetized plasma and its effect on the generation of THz radiation in the presence of relativistic-ponderomotive nonlinearity. The relativistic change of electron mass and electron density perturbation due to the ponderomotive force leads to self-focusing of the laser beam in plasma. Nonlinear coupling between the intense HGLB and electron plasma wave leads to generation of THz radiation in plasma. Resonant excitation of THz radiation at different frequencies of laser and electron plasma wave satisfies proper phase matching conditions. Appropriate expressions for the beam width parameter of the laser beam and the electric vector of the THz wave have been evaluated under the paraxial-ray and Wentzel-Kramers Brillouin approximations. It is found that the yield of THz amplitude depends on the focusing behaviour of laser beam, magnetic field, and background electron density. Numerical simulations have been carried out to investigate the effect of laser and plasma parameters on self-focusing of the laser beam and further its effect on the efficiency of the generated THz radiation.

WE-E-18A-05: Bremsstrahlung of Laser-Plasma Interaction at KeV Temperature: Forward Dose and Attenuation Factors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saez-Beltran, M; Fernandez Gonzalez, F

2014-06-15

Purpose: To obtain an analytical empirical formula for the photon dose source term in forward direction from bremsstrahlung generated from laser-plasma accelerated electron beams in aluminum solid targets, with electron-plasma temperatures in the 10–100 keV energy range, and to calculate transmission factors for iron, aluminum, methacrylate, lead and concrete and air, materials most commonly found in vacuum chamber labs. Methods: Bremsstrahlung fluence is calculated from the convolution of thin-target bremsstrahlung spectrum for monoenergetic electrons and the relativistic Maxwell-Juettner energy distribution for the electron-plasma. Unattenuatted dose in tissue is calculated by integrating the photon spectrum with the mass-energy absorption coefficient. Formore » the attenuated dose, energy dependent absorption coefficient, build-up factors and finite shielding correction factors were also taken into account. For the source term we use a modified formula from Hayashi et al., and we fitted the proportionality constant from experiments with the aid of the previously calculated transmission factors. Results: The forward dose has a quadratic dependence on electron-plasma temperature: 1 joule of effective laser energy transferred to the electrons at 1 m in vacuum yields 0,72 Sv per MeV squared of electron-plasma temperature. Air strongly filters the softer part of the photon spectrum and reduce the dose to one tenth in the first centimeter. Exponential higher energy tail of maxwellian spectrum contributes mainly to the transmitted dose. Conclusion: A simple formula for forward photon dose from keV range temperature plasma is obtained, similar to those found in kilovoltage x-rays but with higher dose per dissipated electron energy, due to thin target and absence of filtration.« less

The effect of different methods of leucoreduction on plasma coagulation factors.

PubMed

Aboul Enein, Azza A; Abdel Rahman, Hala A; Abdel Maged, Mohamed M M; El Sissy, Maha H

2017-03-01

Removal of leucocytes from blood products, namely leucoreduction, improves the safety of blood transfusion by reducing adverse events associated with the incidental transfusion of leucocytes. Coagulation factors might be compromised during leucoreduction because of exposure of plasma to a variety of filter materials. The aim of the current study was to assess the effect of different methods of prestorage leucofiltration (apheresis and whole blood filters) on prothrombin time, international normalized ratio, partial thromboplastin time and factors V and VIII. There was a significant prolongation of prothrombin time as well as elevation of international normalized ratio in plasma after leucoreduction (14.5 ± 0.7 s vs. 13.9 ± 0.7 s, P = 0.008 and 1.14 ± 0.07 vs. 1.09 ± 0.07, P = 0.005, respectively). Also, there was a statistically significant prolongation of activated partial thromboplastin time in nonleucoreduced plasma (55.6 ± 9.9 s vs. 43.2 ± 12.8 s, P = 0.001). There was no significant filtration effect on factors V and VIII levels. Furthermore, there was no significant difference in factors V and VIII levels between plasma filtered by inline whole blood filters and apheresis machine. Leucodepleted plasma originating from both inline whole blood filter and apheresis machine maintained satisfactory levels of factors V and VIII.

Radiosurgery reduces plasma levels of angiogenic factors in brain arteriovenous malformation patients.

PubMed

Xu, Ming; Liu, Xiaoxia; Mei, Guanghai; Zhang, Junjie; Wang, Weixing; Xu, Hongzhi

2018-05-09

Aberrant expression of angiogenic factors has been anecdotally documented in brain arteriovenous malformation (AVM) nidus vessels; however, no data is available on the effect of radiosurgery on the levels of angiogenic factors in AVM patients. We sought to determine the plasma contents of VEGF, TGF-β, Ang-2 and bFGF in 28 brain AVM patients at baseline and post radiosurgery and further analyzed the relationship between plasma contents of these angiogenic factors with clinicopathologic variables of these patients. We enrolled brain AVM patients who underwent Cyberknife radiosurgery at our hospital between January 2014 and December 2015. Brain AVM was confirmed by cerebral angiography and radiosurgery was performed with Cyberknife irradiation. Plasma contents of VEGF, TGF-β, Ang-2 and bFGF were analyzed using commercially available enzyme-linked immunoassay (ELISA) kits. The baseline plasma VEGF content was 222.63 pg/mL (range 43.25-431.25 pg/mL). At three months post surgery, there was a significant -34.29% decline in plasma VEGF content versus baseline (P = 0.000). Furthermore, the median baseline plasma VEGF levels were higher in brain AVM with a nidus volume ≥ 10 cm 3 ) than those with a nidus volume < 10 cm 3 [median(IQR) 293.5 (186.5,359.25) vs. 202 (59.75, 270.75) pg/mL, P = 0.057]. The baseline plasma TGF-β content was 556.17 pg/mL (range 44.44-1486.11 pg/mL) and there was a significant -27.47% decline in plasma TGF-β content at 3 months post radiosurgery versus baseline (P = 0.015). Moreover, the baseline plasma ANG-2 content was 214.27 pg/mL (range 77.14-453.76 pg/mL). There was an immediate and significant -12.47% decline in plasma ANG-2 content post surgery versus baseline (P = 0.002). At three months post surgery, the plasma ANG-2 content still remained significantly depressed versus baseline (P = 0.002). In addition, the baseline plasma bFGF content was 9.17 pg/mL (range 3.67-36.78 pg/mL). No

Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.

PubMed

Mathijssen, Natascha C J; Masereeuw, Rosalinde; Holme, Pal Andre; van Kraaij, Marian G J; Laros-van Gorkom, Britta A P; Peyvandi, Flora; van Heerde, Waander L

2013-08-01

Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. Ten factor VII deficient patients were treated with either recombinant activated (20 μg/kg) or plasma-derived (25 IU/kg) factor VII in a cross-over design. Pharmacokinetic parameters were analyzed through activated factor VII activity, factor VII clotting activity, and factor VII antigen levels on depicted time points. Factor VII activity half-lifes, determined by non-compartmental and one-compartmental analysis (results in brackets), were shorter for recombinant activated (1.4h; 0.7h) than for plasma-derived factor VII (6.8h; 3.2h); both recombinant activated (5.1h; 2.1h and plasma-derived factor VII (5.8h; 3.2h) resulted in longer half-lives of factor VII antigen. Activated factor VII half-lives (based on activated factor VII activity levels) were significantly higher compared to factor VII clotting activity (1.6h; 0.9h). Volumes of distribution were significantly higher for activated factor VII (236 ml/kg; 175 ml/kg, measured by activated factor VII) as compared to plasma-derived factor VII (206 ml/kg; 64 ml/kg, measured by factor FVII activity), suggesting a plasma- and extracellular fluid distribution for recombinant activated factor VII. Recombinant activated factor VII showed significantly shorter half-lifes than plasma-derived factor VII. Volumes of distribution were significantly higher for treatment with recombinant activated factor VII. The longer half-life for plasma-derived factor VII, compared to recombinant activated factor VII, and the increased volume of distribution for recombinant activated factor VII, compared to plasma-derived factor VII may further elucidate the beneficial effect of prophylactic treatment of both products. Copyright © 2013 Elsevier Ltd. All rights reserved.

The Ultraviolet Surprise. Efficient Soft X-Ray High Harmonic Generation in Multiply-Ionized Plasmas

DOE PAGES

Popmintchev, Dimitar; Hernandez-Garcia, Carlos; Dollar, Franklin; ...

2015-12-04

High-harmonic generation is a universal response of matter to strong femtosecond laser fields, coherently upconverting light to much shorter wavelengths. Optimizing the conversion of laser light into soft x-rays typically demands a trade-off between two competing factors. Reduced quantum diffusion of the radiating electron wave function results in emission from each species which is highest when a short-wavelength ultraviolet driving laser is used. But, phase matching—the constructive addition of x-ray waves from a large number of atoms—favors longer-wavelength mid-infrared lasers. We identified a regime of high-harmonic generation driven by 40-cycle ultraviolet lasers in waveguides that can generate bright beams inmore » the soft x-ray region of the spectrum, up to photon energies of 280 electron volts. Surprisingly, the high ultraviolet refractive indices of both neutral atoms and ions enabled effective phase matching, even in a multiply ionized plasma. We observed harmonics with very narrow linewidths, while calculations show that the x-rays emerge as nearly time-bandwidth–limited pulse trains of ~100 attoseconds.« less

Two color laser driven THz generation in clustered plasma

NASA Astrophysics Data System (ADS)

Malik, Rakhee; Uma, R.; Kumar, Pawan

2017-07-01

A scheme of terahertz (THz) generation, using nonlinear mixing of two color laser (fundamental ω1 and slightly frequency shifted second harmonic ω2 ) in clustered plasma, is investigated. The lasers exert ponderomotive force on cluster electrons and drive density perturbations at 2 ω1 and ω2-ω1 . The density perturbations beat with the oscillatory velocities to produce nonlinear current at ω2-2 ω1 , generating THz radiation. The radiation is enhanced due to cluster plasmon resonance and by phase matching introduced through a density ripple. The generation involves third order nonlinearity and does not require a magnetic field or inhomogeneity to sustain it. We report THz power conversion efficiency ˜ 10-4 at 1 μm and 0.5 μm wavelengths with intensity ˜ 3 ×1014W/cm 2 .

Ultraviolet surprise: Efficient soft x-ray high-harmonic generation in multiply ionized plasmas.

PubMed

Popmintchev, Dimitar; Hernández-García, Carlos; Dollar, Franklin; Mancuso, Christopher; Pérez-Hernández, Jose A; Chen, Ming-Chang; Hankla, Amelia; Gao, Xiaohui; Shim, Bonggu; Gaeta, Alexander L; Tarazkar, Maryam; Romanov, Dmitri A; Levis, Robert J; Gaffney, Jim A; Foord, Mark; Libby, Stephen B; Jaron-Becker, Agnieszka; Becker, Andreas; Plaja, Luis; Murnane, Margaret M; Kapteyn, Henry C; Popmintchev, Tenio

2015-12-04

High-harmonic generation is a universal response of matter to strong femtosecond laser fields, coherently upconverting light to much shorter wavelengths. Optimizing the conversion of laser light into soft x-rays typically demands a trade-off between two competing factors. Because of reduced quantum diffusion of the radiating electron wave function, the emission from each species is highest when a short-wavelength ultraviolet driving laser is used. However, phase matching--the constructive addition of x-ray waves from a large number of atoms--favors longer-wavelength mid-infrared lasers. We identified a regime of high-harmonic generation driven by 40-cycle ultraviolet lasers in waveguides that can generate bright beams in the soft x-ray region of the spectrum, up to photon energies of 280 electron volts. Surprisingly, the high ultraviolet refractive indices of both neutral atoms and ions enabled effective phase matching, even in a multiply ionized plasma. We observed harmonics with very narrow linewidths, while calculations show that the x-rays emerge as nearly time-bandwidth-limited pulse trains of ~100 attoseconds. Copyright © 2015, American Association for the Advancement of Science.

Thrombin generation, ProC(®)Global, prothrombin time and activated partial thromboplastin time in thawed plasma stored for seven days and after methylene blue/light pathogen inactivation.

PubMed

Thiele, Thomas; Hron, Gregor; Kellner, Sarah; Wasner, Christina; Westphal, Antje; Warkentin, Theodore E; Greinacher, Andreas; Selleng, Kathleen

2016-01-01

Methylene blue pathogen inactivation and storage of thawed plasma both lead to changes in the activity of several clotting factors. We investigated how this translates into a global loss of thrombin generation potential and alterations in the protein C pathway. Fifty apheresis plasma samples were thawed and each divided into three subunits. One subunit was stored for 7 days at 4 °C, one was stored for 7 days at 22 °C and one was stored at 4 °C after methylene blue/light treatment. Thrombin generation parameters, ProC(®)Global-NR, prothrombin time and activated partial thromboplastin time were assessed on days 0 and 7. The velocity of thrombin generation increased significantly after methylene blue treatment (increased thrombin generation rate; time to peak decreased) and decreased after storage (decreased thrombin generation rate and peak thrombin; increased lag time and time to peak). The endogenous thrombin generation potential remained stable after methylene blue treatment and storage at 4 °C. Methylene blue treatment and 7 days of storage at 4 °C activated the protein C pathway, whereas storage at room temperature and storage after methylene blue treatment decreased the functional capacity of the protein C pathway. Prothrombin time and activated partial thromboplastin time showed only modest alterations. The global clotting capacity of thawed plasma is maintained at 4 °C for 7 days and directly after methylene blue treatment of thawed plasma. Thrombin generation and ProC(®)Global are useful tools for investigating the impact of pathogen inactivation and storage on the clotting capacity of therapeutic plasma preparations.

A Tesla-pulse forming line-plasma opening switch pulsed power generator.

PubMed

Novac, B M; Kumar, R; Smith, I R

2010-10-01

A pulsed power generator based on a high-voltage Tesla transformer which charges a 3.85 Ω/55 ns water-filled pulse forming line to 300 kV has been developed at Loughborough University as a training tool for pulsed power students. The generator uses all forms of insulation specific to pulsed power technology, liquid (oil and water), gas (SF(6)), and magnetic insulation in vacuum, and a number of fast voltage and current sensors are implemented for diagnostic purposes. A miniature (centimeter-size) plasma opening switch has recently been coupled to the output of the pulse forming line, with the overall system comprising the first phase of a program aimed at the development of a novel repetitive, table-top generator capable of producing 15 GW pulses for high power microwave loads. Technical details of all the generator components and the main experimental results obtained during the program and demonstrations of their performance are presented in the paper, together with a description of the various diagnostic tools involved. In particular, it is shown that the miniature plasma opening switch is capable of reducing the rise time of the input current while significantly increasing the load power. Future plans are outlined in the conclusions.

Ovulation-inducing factor: a protein component of llama seminal plasma

PubMed Central

2010-01-01

Background Previously, we documented the presence of ovulation-inducing factor (OIF) in the seminal plasma of llamas and alpacas. The purpose of the study was to define the biochemical characteristics of the molecule(s) in seminal plasma responsible for inducing ovulation. Methods In Experiment 1, llama seminal plasma was centrifuged using filtration devices with nominal molecular mass cut-offs of 30, 10 and 5 kDa. Female llamas (n = 9 per group) were treated i.m. with whole seminal plasma (positive control), phosphate-buffered saline (negative control), or the fraction of seminal plasma equal or higher than 30 kDa, 10 to 30 kDa, 5 to 10 kDa, or < 5 kDa. In Experiment 2, female llamas (n = 7 per group) were given an i.m. dose of seminal plasma treated previously by: 1) enzymatic digestion with proteinase-K, 2) incubation with charcoal-dextran, 3) heating to 65°C, or 4) untreated (control). In Experiment 3, female llamas (n = 10 per group) were given an i.m. dose of pronase-treated or non-treated (control) seminal plasma. In all experiments, llamas were examined by transrectal ultrasonography to detect ovulation and CL formation. Ovulation rate was compared among groups by Fisher's exact test and follicle and CL diameters were compared among groups by analyses of variance or student's t-tests. Results In Experiment 1, all llamas in the equal or higher than 30 kDa and positive control groups ovulated (9/9 in each), but none ovulated in the other groups (P < 0.001). In Experiment 2, ovulations were detected in all llamas in each treatment group; i.e., respective treatments of seminal plasma failed to inactivate the ovulation-inducing factor. In Experiment 3, ovulations were detected in 0/10 llamas given pronase-treated seminal plasma and in 9/10 controls (P < 0.01). Conclusions We conclude that ovulation-inducing factor (OIF) in llama seminal plasma is a protein molecule that is resistant to heat and enzymatic digestion with proteinase K, and has a molecular mass of

Components in Plasma-Derived Factor VIII, But Not in Recombinant Factor VIII Downregulate Anti-Inflammatory Surface Marker CD163 in Human Macrophages through Release of CXCL4 (Platelet Factor 4)

PubMed Central

Bertling, Anne; Brodde, Martin F.; Visser, Mayken; Treffon, Janina; Fennen, Michelle; Fender, Anke C.; Kelsch, Reinhard; Kehrel, Beate E.

2017-01-01

Background Hemarthrosis, or bleeding into the joints, is a hallmark of hemophilia. Heme triggers oxidative stress, inflammation, and destruction of cartilage and bone. The haptoglobin-CD163-heme oxygenase-1 (HO-1) pathway circumvents heme toxicity through enzymatic degradation of heme and transcription of antioxidant genes. Plasma-derived factor concentrates contain many proteins that might impact on cellular pathways in joints, blood, and vessels. Methods Activation of platelets from healthy volunteers was assessed by flow cytometry analysis of fibrinogen binding and CD62P expression. Platelet CXCL4 release was measured by ELISA. Human peripheral blood mononuclear cells were exposed to CXCL4 or platelet supernatants (untreated or pre-stimulated with factor VIII (FVIII) products) during their differentiation to macrophages and analyzed for CD163 expression. Some macrophage cultures were additionally incubated with autologous hemoglobin for 18 h for analysis of HO-1 expression. Results Platelet CXCL4 release was increased by all 8 tested plasma-derived FVIII products but not the 3 recombinant products. Macrophages exposed to supernatant from platelets treated with some plasma-derived FVIII products downregulated CD163 surface expression and failed to upregulate the athero- and joint protective enzyme HO-1 in response to hemoglobin. Conclusion Plasma-derived FVIII products might promote bleeding-induced joint injury via generation of macrophages that are unable to counteract redox stress. PMID:29070980

Components in Plasma-Derived Factor VIII, But Not in Recombinant Factor VIII Downregulate Anti-Inflammatory Surface Marker CD163 in Human Macrophages through Release of CXCL4 (Platelet Factor 4).

PubMed

Bertling, Anne; Brodde, Martin F; Visser, Mayken; Treffon, Janina; Fennen, Michelle; Fender, Anke C; Kelsch, Reinhard; Kehrel, Beate E

2017-09-01

Hemarthrosis, or bleeding into the joints, is a hallmark of hemophilia. Heme triggers oxidative stress, inflammation, and destruction of cartilage and bone. The haptoglobin-CD163-heme oxygenase-1 (HO-1) pathway circumvents heme toxicity through enzymatic degradation of heme and transcription of antioxidant genes. Plasma-derived factor concentrates contain many proteins that might impact on cellular pathways in joints, blood, and vessels. Activation of platelets from healthy volunteers was assessed by flow cytometry analysis of fibrinogen binding and CD62P expression. Platelet CXCL4 release was measured by ELISA. Human peripheral blood mononuclear cells were exposed to CXCL4 or platelet supernatants (untreated or pre-stimulated with factor VIII (FVIII) products) during their differentiation to macrophages and analyzed for CD163 expression. Some macrophage cultures were additionally incubated with autologous hemoglobin for 18 h for analysis of HO-1 expression. Platelet CXCL4 release was increased by all 8 tested plasma-derived FVIII products but not the 3 recombinant products. Macrophages exposed to supernatant from platelets treated with some plasma-derived FVIII products downregulated CD163 surface expression and failed to upregulate the athero- and joint protective enzyme HO-1 in response to hemoglobin. Plasma-derived FVIII products might promote bleeding-induced joint injury via generation of macrophages that are unable to counteract redox stress.

Graft Product for Autologous Peripheral Blood Stem Cell Transplantation Enhances Thrombin Generation and Expresses Procoagulant Microparticles and Tissue Factor.

PubMed

Sidibe, Fatoumata; Spanoudaki, Anastasia; Vanneaux, Valerie; Mbemba, Elisabeth; Larghero, Jerome; Van Dreden, Patrick; Lotz, Jean-Pierre; Elalamy, Ismail; Larsen, Annette K; Gerotziafas, Grigoris T

2018-05-01

The beneficial effect of autologous peripheral blood stem cell transplantation (APBSCT) may be compromised by acute vascular complications related to hypercoagulability. We studied the impact of graft product on thrombin generation of normal plasma and the expression of tissue factor (TF) and procoagulant platelet-derived procoagulant microparticles (Pd-MPs) in samples of graft products. Graft products from 10 patients eligible for APBSCT were mixed with platelet-poor plasma (PPP) or platelet-rich plasma (PRP) from healthy volunteers and assessed for in vitro thrombin generation. In control experiments, thrombin generation was assessed in (1) PPP and PRP without any exogenous TF and/or procoagulant phospholipids, (2) PPP with the addition of TF (5 pM) and procoagulant phospholipids (4 μM), (3) in PRP with the addition of TF (5 pM). Graft products were assessed with Western blot assay for TF expression, with a specific clotting assay for TF activity and with flow cytometry assay for Pd-MPs. The graft product enhanced thrombin generation and its procoagulant activity was related to the presence of Pd-MPs and TF. The concentration of Pd-MPs in the graft product was characterized by a significant interindividual variability. The present study reveals the need for a thorough quality control of the graft products regarding their procoagulant potential.

Generation of Autologous Platelet-Rich Plasma by the Ultrasonic Standing Waves.

PubMed

Wu, Yue; Kanna, Murugappan Suresh; Liu, Chenhui; Zhou, Yufeng; Chan, Casey K

2016-08-01

Platelet-rich plasma (PRP) is a volume of autologous plasma that has a higher platelet concentration above baseline. It has already been approved as a new therapeutic modality and investigated in clinics, such as bone repair and regeneration, and oral surgery, with low cost-effectiveness ratio. At present, PRP is mostly prepared using a centrifuge. However, this method has several shortcomings, such as long preparation time (30 min), complexity in operation, and contamination of red blood cells (RBCs). In this paper, a new PRP preparation approach was proposed and tested. Ultrasound waves (4.5 MHz) generated from piezoelectric ceramics can establish standing waves inside a syringe filled with the whole blood. Subsequently, RBCs would accumulate at the locations of pressure nodes in response to acoustic radiation force, and the formed clusters would have a high speed of sedimentation. It is found that the PRP prepared by the proposed device can achieve higher platelet concentration and less RBCs contamination than a commercial centrifugal device, but similar growth factor (i.e., PDGF-ββ). In addition, the sedimentation process under centrifugation and sonication was simulated using the Mason-Weaver equation and compared with each other to illustrate the differences between these two technologies and to optimize the design in the future. Altogether, ultrasound method is an effective method of PRP preparation with comparable outcomes as the commercially available centrifugal products.

Generation of various radicals in nitrogen plasma and their behavior in media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uhm, Han S., E-mail: hsuhm@kw.ac.kr

2015-12-15

Research on the generation of radicals in nitrogen plasma shows that the most dominant radicals are excited nitrogen molecules in the metastable state of N{sub 2}(A{sub 3}∑{sub u}{sup +}). Hydroxyl molecules are generated from the dissociation of water molecules upon contact with excited nitrogen molecules. The estimated densities of various radicals in nitrogen plasma with an electron temperature of 1 eV are presented in this study. The behavior of these radicals in media is also investigated. Excited nitrogen molecules in the N{sub 2}(A{sub 3}∑{sub u}{sup +}) state from a plasma jet are injected into water, after which the molecules disappear instantaneouslymore » within a few tens of nm, producing hydroxyl molecules. Hydrogen peroxide, hydrogen dioxide, and nitrogen monoxide molecules can diffuse much deeper into water, implying the possibility that a chemical reaction between hydrogen dioxide and nitrogen monoxide molecules produces hydroxyl molecules in deep water, even though density in this case may not be very high.« less

Influence of Pre-Analytical Factors on Thymus- and Activation-Regulated Chemokine Quantitation in Plasma

PubMed Central

Zhao, Xuemei; Delgado, Liliana; Weiner, Russell; Laterza, Omar F.

2015-01-01

Thymus- and activation-regulated chemokine (TARC) in serum/plasma associates with the disease activity of atopic dermatitis (AD), and is a promising tool for assessing the response to the treatment of the disease. TARC also exists within platelets, with elevated levels detectable in AD patients. We examined the effects of pre-analytical factors on the quantitation of TARC in human EDTA plasma. TARC levels in platelet-free plasma were significantly lower than those in platelet-containing plasma. After freeze-thaw, TARC levels increased in platelet-containing plasma, but remained unchanged in platelet-free plasma, suggesting TARC was released from the platelets during the freeze-thaw process. In contrast, TARC levels were stable in serum independent of freeze-thaw. These findings underscore the importance of pre-analytical factors to TARC quantitation. Plasma TARC levels should be measured in platelet-free plasma for accurate quantitation. Pre-analytical factors influence the quantitation, interpretation, and implementation of circulating TARC as a biomarker for the development of AD therapeutics. PMID:28936246

Bernstein wave aided laser third harmonic generation in a plasma

NASA Astrophysics Data System (ADS)

Tyagi, Yachna; Tripathi, Deepak; Kumar, Ashok

2016-09-01

The process of Bernstein wave aided resonant third harmonic generation of laser in a magnetized plasma is investigated. The extra-ordinary mode (X-mode) laser of frequency ω 0 and wave number k → 0 , travelling across the magnetic field in a plasma, exerts a second harmonic ponderomotive force on the electrons imparting them an oscillatory velocity v → 2 ω0 , 2 k → 0 . This velocity beats with the density perturbation due to the Bernstein wave to produce a density perturbation at cyclotron frequency shifted second harmonic. The density perturbation couples with the oscillatory velocity v → ω0 , k → 0 of X-mode of the laser to produce the cyclotron frequency shifted third harmonic current density leading to harmonic radiation. The phase matching condition for the up shifted frequency is satisfied when the Bernstein wave is nearly counter-propagating to the laser. As the transverse wave number of the Bernstein wave is large, it is effective in the phase matched third harmonic generation, when the laser frequency is not too far from the upper hybrid frequency.

Efficient quasi-monoenergetic ion beams up to 18 MeV/nucleon via self-generated plasma fields in relativistic laser plasmas

NASA Astrophysics Data System (ADS)

Palaniyappan, Sasi; Huang, Chengkun; Gautier, Donald; Hamilton, Christopher; Santiago, Miguel; Kreuzer, Christian; Shah, Rahul; Fernandez, Juan; Los Alamos National Laboratory Team; Ludwig-Maximilian-University Team

2015-11-01

Table-top laser-plasma ion accelerators seldom achieve narrow energy spreads, and never without serious compromises in efficiency, particle yield, etc. Using massive computer simulations, we identify a self-organizing scheme that exploits persisting self-generated plasma electric (~ TV/m) and magnetic (~ 104 Tesla) fields to reduce the ion energy spread after the laser exits the plasma - separating the ion acceleration from the energy spread reduction. Consistent with the scheme, we experimentally demonstrate aluminum and carbon ion beams with narrow spectral peaks at energies up to 310 MeV (11.5 MeV/nucleon) and 220 MeV (18.3 MeV/nucleon), respectively, with high conversion efficiency (~ 5%, i.e., 4J out of 80J laser). This is achieved with 0.12 PW high-contrast Gaussian laser pulses irradiating planar foils with optimal thicknesses of up to 250 nm that scale with laser intensity. When increasing the focused laser intensity fourfold (by reducing the focusing optic f/number twofold), the spectral-peak energy increases twofold. These results pave the way for next generation compact accelerators suitable for applications. For example, 400 MeV (33.3 MeV/nucleon) carbon-ion beam with narrow energy spread required for ion fast ignition could be generated using PW-class lasers.

Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation

PubMed Central

Eisenhauer, Peter; Chernets, Natalie; Song, You; Dobrynin, Danil; Pleshko, Nancy; Steinbeck, Marla J.; Freeman, Theresa A.

2017-01-01

The goal of this study was to investigate whether cold plasma generated by dielectric barrier discharge (DBD) modifies extracellular matrices (ECM) to influence chondrogenesis and endochondral ossification. Replacement of cartilage by bone during endochondral ossification is essential in fetal skeletal development, bone growth and fracture healing. Regulation of this process by the ECM occurs through matrix remodelling, involving a variety of cell attachment molecules and growth factors, which influence cell morphology and protein expression. The commercially available ECM, Matrigel, was treated with microsecond or nanosecond pulsed (µsp or nsp, respectively) DBD frequencies conditions at the equivalent frequencies (1 kHz) or power (~1 W). Recombinant human bone morphogenetic protein-2 was added and the mixture subcutaneously injected into mice to simulate ectopic endochondral ossification. Two weeks later, the masses were extracted and analysed by microcomputed tomography. A significant increase in bone formation was observed in Matrigel treated with µsp DBD compared with control, while a significant decrease in bone formation was observed for both nsp treatments. Histological and immunohistochemical analysis showed Matrigel treated with µsp plasma increased the number of invading cells, the amount of vascular endothelial growth factor and chondrogenesis while the opposite was true for Matrigel treated with nsp plasma. In support of the in vivo Matrigel study, 10 T1/2 cells cultured in vitro on µsp DBD-treated type I collagen showed increased expression of adhesion proteins and activation of survival pathways, which decreased with nsp plasma treatments. These results indicate DBD modification of ECM can influence cellular behaviours to accelerate or inhibit chondrogenesis and endochondral ossification. PMID:27510797

Factors influencing plasma transfusion practices in paediatric intensive care units around the world.

PubMed

Karam, O; Demaret, P; Duhamel, A; Shefler, A; Spinella, P C; Tucci, M; Leteurtre, S; Stanworth, S J

2017-02-01

Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma to >5% of their patients, whereas another 25% transfused plasma to <1% of their patients. The objective of this study was to explore the factors associated with different plasma transfusion practices in these centres. Online survey sent to the local investigators of the 101 participating centres, in February 2016. Four areas were explored: beliefs regarding plasma transfusion, patients' case-mix in each unit, unit's characteristics, and local blood product transfusion policies and processes. The response rate was 82% (83/101). 43% of the respondents believed that plasma transfusions can arrest bleeding, whereas 27% believe that plasma transfusion can prevent bleeding. Centres with the highest plasma transfusion rate were more likely to think that hypovolaemia and mildly abnormal coagulation tests are appropriate indications for plasma transfusions (P = 0·02 and P = 0·04, respectively). Case-mix, centre characteristics or local transfusion services were not identified as significant relevant factors. Factors influencing plasma transfusion practices reflect beliefs about indications and the efficacy of transfusion in the prevention and management of bleeding as well as effects on coagulation tests. Educational and other initiatives to target these beliefs should be the focus of research. © 2017 International Society of Blood Transfusion.

Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors

PubMed Central

Belderbos, Mirjam E.; Levy, Ofer; Stalpers, Femke; Kimpen, Jan L.; Meyaard, Linde; Bont, Louis

2012-01-01

Human neonates are highly susceptible to infection, which may be due in part to impaired innate immune function. Neonatal Toll-like receptor (TLR) responses are biased against the generation of pro-inflammatory/Th1-polarizing cytokines, yet the underlying mechanisms are incompletely defined. Here, we demonstrate that neonatal plasma polarizes TLR4-mediated cytokine production. When exposed to cord blood plasma, mononuclear cells (MCs) produced significantly lower TLR4-mediated IL-12p70 and higher IL-10 compared to MC exposed to adult plasma. Suppression by neonatal plasma of TLR4-mediated IL-12p70 production, but not induction of TLR4-mediated IL-10 production, was maintained up to the age of 1 month. Cord blood plasma conferred a similar pattern of MC cytokine responses to TLR3 and TLR8 agonists, demonstrating activity towards both MyD88-dependent and MyD88-independent agonists. The factor causing increased TLR4-mediated IL-10 production by cord blood plasma was heat-labile, lost after protein depletion and independent of lipoprotein binding protein (LBP) or soluble CD14 (sCD14). The factor causing inhibition of TLR4-mediated IL-12p70 production by cord blood plasma was resistant to heat inactivation or protein depletion and was independent of IL-10, vitamin D and prostaglandin E2. In conclusion, human neonatal plasma contains at least two distinct factors that suppress TLR4-mediated IL-12p70 production or induce IL-10 or production. Further identification of these factors will provide insight into the ontogeny of innate immune development and might identify novel targets for the prevention and treatment of neonatal infection. PMID:22442690

Measurement of activated species generated by AC power excited non-equilibrium atmospheric pressure Ar plasma jet with air engulfment

NASA Astrophysics Data System (ADS)

Takeda, Keigo; Ishikawa, Kenji; Tanaka, Hiromasa; Kano, Hiroyuki; Sekine, Makoto; Hori, Masaru

2013-09-01

Non-equilibrium atmospheric pressure plasma jet (NEAPPJ) is very attractive tool for bio and medical applications. In the plasma treatments, samples are typically located at a far region from main discharge, and treated in open air without purge gases. Influence of air engulfment on generation of activated species in the NEAPPJ in open air is a large issue for the application. In this study, the AC excited argon NEAPPJ with the gas flow rate of 2 slm was generated under the open air condition. The densities of the grand state nitrogen monoxide (NO) and the ground state O atom generated by the NEAPPJ were measured by laser induced fluorescence spectroscopy and vacuum ultraviolet absorption spectroscopy. The length of the plasma jet was around 10 mm. Up to 10 mm, the NO density increased with increasing the distance from plasma head, and then saturated in remote region of plasma. On the other hand, the O atom density decreased from 1014 to 1013 cm-3 with increasing the distance. Especially, the amount of decrease in O atom density became the largest at the plasma edge. We will discuss the generation and loss processes of activated species generated in the NEAPPJ with the measurement results using spectroscopic methods.

Energy loss of argon in a laser-generated carbon plasma.

PubMed

Frank, A; Blazević, A; Grande, P L; Harres, K; Hessling, T; Hoffmann, D H H; Knobloch-Maas, R; Kuznetsov, P G; Nürnberg, F; Pelka, A; Schaumann, G; Schiwietz, G; Schökel, A; Schollmeier, M; Schumacher, D; Schütrumpf, J; Vatulin, V V; Vinokurov, O A; Roth, M

2010-02-01

The experimental data presented in this paper address the energy loss determination for argon at 4 MeV/u projectile energy in laser-generated carbon plasma covering a huge parameter range in density and temperature. Furthermore, a consistent theoretical description of the projectile charge state evolution via a Monte Carlo code is combined with an improved version of the CasP code that allows us to calculate the contributions to the stopping power of bound and free electrons for each projectile charge state. This approach gets rid of any effective charge description of the stopping power. Comparison of experimental data and theoretical results allows us to judge the influence of different plasma parameters.

Next generation of Z* modelling tool for high intensity EUV and soft x-ray plasma sources simulations

NASA Astrophysics Data System (ADS)

Zakharov, S. V.; Zakharov, V. S.; Choi, P.; Krukovskiy, A. Y.; Novikov, V. G.; Solomyannaya, A. D.; Berezin, A. V.; Vorontsov, A. S.; Markov, M. B.; Parot'kin, S. V.

2011-04-01

In the specifications for EUV sources, high EUV power at IF for lithography HVM and very high brightness for actinic mask and in-situ inspections are required. In practice, the non-equilibrium plasma dynamics and self-absorption of radiation limit the in-band radiance of the plasma and the usable radiation power of a conventional single unit EUV source. A new generation of the computational code Z* is currently developed under international collaboration in the frames of FP7 IAPP project FIRE for modelling of multi-physics phenomena in radiation plasma sources, particularly for EUVL. The radiation plasma dynamics, the spectral effects of self-absorption in LPP and DPP and resulting Conversion Efficiencies are considered. The generation of fast electrons, ions and neutrals is discussed. Conditions for the enhanced radiance of highly ionized plasma in the presence of fast electrons are evaluated. The modelling results are guiding a new generation of EUV sources being developed at Nano-UV, based on spatial/temporal multiplexing of individual high brightness units, to deliver the requisite brightness and power for both lithography HVM and actinic metrology applications.

Experimental validation of a Lyapunov-based controller for the plasma safety factor and plasma pressure in the TCV tokamak

NASA Astrophysics Data System (ADS)

Mavkov, B.; Witrant, E.; Prieur, C.; Maljaars, E.; Felici, F.; Sauter, O.; the TCV-Team

2018-05-01

In this paper, model-based closed-loop algorithms are derived for distributed control of the inverse of the safety factor profile and the plasma pressure parameter β of the TCV tokamak. The simultaneous control of the two plasma quantities is performed by combining two different control methods. The control design of the plasma safety factor is based on an infinite-dimensional setting using Lyapunov analysis for partial differential equations, while the control of the plasma pressure parameter is designed using control techniques for single-input and single-output systems. The performance and robustness of the proposed controller is analyzed in simulations using the fast plasma transport simulator RAPTOR. The control is then implemented and tested in experiments in TCV L-mode discharges using the RAPTOR model predicted estimates for the q-profile. The distributed control in TCV is performed using one co-current and one counter-current electron cyclotron heating actuation.

Experimental design to generate strong shear layers in a high-energy-density plasma

NASA Astrophysics Data System (ADS)

Harding, E. C.; Drake, R. P.; Aglitskiy, Y.; Gillespie, R. S.; Grosskopf, M. J.; Weaver, J. L.; Velikovich, A. L.; Visco, A.; Ditmar, J. R.

2010-06-01

The development of a new experimental system for generating a strong shear flow in a high-energy-density plasma is described in detail. The targets were designed with the goal of producing a diagnosable Kelvin-Helmholtz (KH) instability, which plays an important role in the transition turbulence but remains relatively unexplored in the high-energy-density regime. To generate the shear flow the Nike laser was used to drive a flow of Al plasma over a low-density foam surface with an initial perturbation. The interaction of the Al and foam was captured with a spherical crystal imager using 1.86 keV X-rays. The selection of the individual targets components is discussed and results are presented.

Generation of two-dimensional binary mixtures in complex plasmas

NASA Astrophysics Data System (ADS)

Wieben, Frank; Block, Dietmar

2016-10-01

Complex plasmas are an excellent model system for strong coupling phenomena. Under certain conditions the dust particles immersed into the plasma form crystals which can be analyzed in terms of structure and dynamics. Previous experiments focussed mostly on monodisperse particle systems whereas dusty plasmas in nature and technology are polydisperse. Thus, a first and important step towards experiments in polydisperse systems are binary mixtures. Recent experiments on binary mixtures under microgravity conditions observed a phase separation of particle species with different radii even for small size disparities. This contradicts several numerical studies of 2D binary mixtures. Therefore, dedicated experiments are required to gain more insight into the physics of polydisperse systems. In this contribution first ground based experiments on two-dimensional binary mixtures are presented. Particular attention is paid to the requirements for the generation of such systems which involve the consideration of the temporal evolution of the particle properties. Furthermore, the structure of these two-component crystals is analyzed and compared to simulations. This work was supported by the Deutsche Forschungsgemeinschaft DFG in the framework of the SFB TR24 Greifswald Kiel, Project A3b.

Efficient generation of energetic ions in multi-ion plasmas by radio-frequency heating

NASA Astrophysics Data System (ADS)

Kazakov, Ye. O.; Ongena, J.; Wright, J. C.; Wukitch, S. J.; Lerche, E.; Mantsinen, M. J.; van Eester, D.; Craciunescu, T.; Kiptily, V. G.; Lin, Y.; Nocente, M.; Nabais, F.; Nave, M. F. F.; Baranov, Y.; Bielecki, J.; Bilato, R.; Bobkov, V.; Crombé, K.; Czarnecka, A.; Faustin, J. M.; Felton, R.; Fitzgerald, M.; Gallart, D.; Giacomelli, L.; Golfinopoulos, T.; Hubbard, A. E.; Jacquet, Ph.; Johnson, T.; Lennholm, M.; Loarer, T.; Porkolab, M.; Sharapov, S. E.; Valcarcel, D.; van Schoor, M.; Weisen, H.; Marmar, E. S.; Baek, S. G.; Barnard, H.; Bonoli, P.; Brunner, D.; Candy, J.; Canik, J.; Churchill, R. M.; Cziegler, I.; Dekow, G.; Delgado-Aparicio, L.; Diallo, A.; Edlund, E.; Ennever, P.; Faust, I.; Fiore, C.; Gao, Chi; Golfinopoulos, T.; Greenwald, M.; Hartwig, Z. S.; Holland, C.; Hubbard, A. E.; Hughes, J. W.; Hutchinson, I. H.; Irby, J.; Labombard, B.; Lin, Yijun; Lipschultz, B.; Loarte, A.; Mumgaard, R.; Parker, R. R.; Porkolab, M.; Reinke, M. L.; Rice, J. E.; Scott, S.; Shiraiwa, S.; Snyder, P.; Sorbom, B.; Terry, D.; Terry, J. L.; Theiler, C.; Vieira, R.; Walk, J. R.; Wallace, G. M.; White, A.; Whyte, D.; Wolfe, S. M.; Wright, G. M.; Wright, J.; Wukitch, S. J.; Xu, P.; Abduallev, S.; Abhangi, M.; Abreu, P.; Afzal, M.; Aggarwal, K. M.; Ahlgren, T.; Ahn, J. H.; Aho-Mantila, L.; Aiba, N.; Airila, M.; Albanese, R.; Aldred, V.; Alegre, D.; Alessi, E.; Aleynikov, P.; Alfier, A.; Alkseev, A.; Allinson, M.; Alper, B.; Alves, E.; Ambrosino, G.; Ambrosino, R.; Amicucci, L.; Amosov, V.; Sundén, E. Andersson; Angelone, M.; Anghel, M.; Angioni, C.; Appel, L.; Appelbee, C.; Arena, P.; Ariola, M.; Arnichand, H.; Arshad, S.; Ash, A.; Ashikawa, N.; Aslanyan, V.; Asunta, O.; Auriemma, F.; Austin, Y.; Avotina, L.; Axton, M. D.; Ayres, C.; Bacharis, M.; Baciero, A.; Baião, D.; Bailey, S.; Baker, A.; Balboa, I.; Balden, M.; Balshaw, N.; Bament, R.; Banks, J. W.; Baranov, Y. F.; Barnard, M. A.; Barnes, D.; Barnes, M.; Barnsley, R.; Wiechec, A. Baron; Orte, L. Barrera; Baruzzo, M.; Basiuk, V.; Bassan, M.; Bastow, R.; Batista, A.; Batistoni, P.; Baughan, R.; Bauvir, B.; Baylor, L.; Bazylev, B.; Beal, J.; Beaumont, P. S.; Beckers, M.; Beckett, B.; Becoulet, A.; Bekris, N.; Beldishevski, M.; Bell, K.; Belli, F.; Bellinger, M.; Belonohy, É.; Ayed, N. Ben; Benterman, N. A.; Bergsåker, H.; Bernardo, J.; Bernert, M.; Berry, M.; Bertalot, L.; Besliu, C.; Beurskens, M.; Bieg, B.; Bielecki, J.; Biewer, T.; Bigi, M.; Bílková, P.; Binda, F.; Bisoffi, A.; Bizarro, J. P. S.; Björkas, C.; Blackburn, J.; Blackman, K.; Blackman, T. R.; Blanchard, P.; Blatchford, P.; Bobkov, V.; Boboc, A.; Bodnár, G.; Bogar, O.; Bolshakova, I.; Bolzonella, T.; Bonanomi, N.; Bonelli, F.; Boom, J.; Booth, J.; Borba, D.; Borodin, D.; Borodkina, I.; Botrugno, A.; Bottereau, C.; Boulting, P.; Bourdelle, C.; Bowden, M.; Bower, C.; Bowman, C.; Boyce, T.; Boyd, C.; Boyer, H. J.; Bradshaw, J. M. A.; Braic, V.; Bravanec, R.; Breizman, B.; Bremond, S.; Brennan, P. D.; Breton, S.; Brett, A.; Brezinsek, S.; Bright, M. D. J.; Brix, M.; Broeckx, W.; Brombin, M.; Brosławski, A.; Brown, D. P. D.; Brown, M.; Bruno, E.; Bucalossi, J.; Buch, J.; Buchanan, J.; Buckley, M. A.; Budny, R.; Bufferand, H.; Bulman, M.; Bulmer, N.; Bunting, P.; Buratti, P.; Burckhart, A.; Buscarino, A.; Busse, A.; Butler, N. K.; Bykov, I.; Byrne, J.; Cahyna, P.; Calabrò, G.; Calvo, I.; Camenen, Y.; Camp, P.; Campling, D. C.; Cane, J.; Cannas, B.; Capel, A. J.; Card, P. J.; Cardinali, A.; Carman, P.; Carr, M.; Carralero, D.; Carraro, L.; Carvalho, B. B.; Carvalho, I.; Carvalho, P.; Casson, F. J.; Castaldo, C.; Catarino, N.; Caumont, J.; Causa, F.; Cavazzana, R.; Cave-Ayland, K.; Cavinato, M.; Cecconello, M.; Ceccuzzi, S.; Cecil, E.; Cenedese, A.; Cesario, R.; Challis, C. D.; Chandler, M.; Chandra, D.; Chang, C. S.; Chankin, A.; Chapman, I. T.; Chapman, S. C.; Chernyshova, M.; Chitarin, G.; Ciraolo, G.; Ciric, D.; Citrin, J.; Clairet, F.; Clark, E.; Clark, M.; Clarkson, R.; Clatworthy, D.; Clements, C.; Cleverly, M.; Coad, J. P.; Coates, P. A.; Cobalt, A.; Coccorese, V.; Cocilovo, V.; Coda, S.; Coelho, R.; Coenen, J. W.; Coffey, I.; Colas, L.; Collins, S.; Conka, D.; Conroy, S.; Conway, N.; Coombs, D.; Cooper, D.; Cooper, S. R.; Corradino, C.; Corre, Y.; Corrigan, G.; Cortes, S.; Coster, D.; Couchman, A. S.; Cox, M. P.; Craciunescu, T.; Cramp, S.; Craven, R.; Crisanti, F.; Croci, G.; Croft, D.; Crombé, K.; Crowe, R.; Cruz, N.; Cseh, G.; Cufar, A.; Cullen, A.; Curuia, M.; Czarnecka, A.; Dabirikhah, H.; Dalgliesh, P.; Dalley, S.; Dankowski, J.; Darrow, D.; Davies, O.; Davis, W.; Day, C.; Day, I. E.; de Bock, M.; de Castro, A.; de La Cal, E.; de La Luna, E.; Masi, G. De; de Pablos, J. L.; de Temmerman, G.; de Tommasi, G.; de Vries, P.; Deakin, K.; Deane, J.; Agostini, F. Degli; Dejarnac, R.; Delabie, E.; den Harder, N.; Dendy, R. O.; Denis, J.; Denner, P.; Devaux, S.; Devynck, P.; Maio, F. Di; Siena, A. Di; Troia, C. Di; Dinca, P.; D'Inca, R.; Ding, B.; Dittmar, T.; Doerk, H.; Doerner, R. P.; Donné, T.; Dorling, S. E.; Dormido-Canto, S.; Doswon, S.; Douai, D.; Doyle, P. T.; Drenik, A.; Drewelow, P.; Drews, P.; Duckworth, Ph.; Dumont, R.; Dumortier, P.; Dunai, D.; Dunne, M.; Ďuran, I.; Durodié, F.; Dutta, P.; Duval, B. P.; Dux, R.; Dylst, K.; Dzysiuk, N.; Edappala, P. V.; Edmond, J.; Edwards, A. M.; Edwards, J.; Eich, Th.; Ekedahl, A.; El-Jorf, R.; Elsmore, C. G.; Enachescu, M.; Ericsson, G.; Eriksson, F.; Eriksson, J.; Eriksson, L. G.; Esposito, B.; Esquembri, S.; Esser, H. G.; Esteve, D.; Evans, B.; Evans, G. E.; Evison, G.; Ewart, G. D.; Fagan, D.; Faitsch, M.; Falie, D.; Fanni, A.; Fasoli, A.; Faustin, J. M.; Fawlk, N.; Fazendeiro, L.; Fedorczak, N.; Felton, R. C.; Fenton, K.; Fernades, A.; Fernandes, H.; Ferreira, J.; Fessey, J. A.; Février, O.; Ficker, O.; Field, A.; Fietz, S.; Figueiredo, A.; Figueiredo, J.; Fil, A.; Finburg, P.; Firdaouss, M.; Fischer, U.; Fittill, L.; Fitzgerald, M.; Flammini, D.; Flanagan, J.; Fleming, C.; Flinders, K.; Fonnesu, N.; Fontdecaba, J. M.; Formisano, A.; Forsythe, L.; Fortuna, L.; Fortuna-Zalesna, E.; Fortune, M.; Foster, S.; Franke, T.; Franklin, T.; Frasca, M.; Frassinetti, L.; Freisinger, M.; Fresa, R.; Frigione, D.; Fuchs, V.; Fuller, D.; Futatani, S.; Fyvie, J.; Gál, K.; Galassi, D.; Gałązka, K.; Galdon-Quiroga, J.; Gallagher, J.; Gallart, D.; Galvão, R.; Gao, X.; Gao, Y.; Garcia, J.; Garcia-Carrasco, A.; García-Muñoz, M.; Gardarein, J.-L.; Garzotti, L.; Gaudio, P.; Gauthier, E.; Gear, D. F.; Gee, S. J.; Geiger, B.; Gelfusa, M.; Gerasimov, S.; Gervasini, G.; Gethins, M.; Ghani, Z.; Ghate, M.; Gherendi, M.; Giacalone, J. C.; Giacomelli, L.; Gibson, C. S.; Giegerich, T.; Gil, C.; Gil, L.; Gilligan, S.; Gin, D.; Giovannozzi, E.; Girardo, J. B.; Giroud, C.; Giruzzi, G.; Glöggler, S.; Godwin, J.; Goff, J.; Gohil, P.; Goloborod'Ko, V.; Gomes, R.; Gonçalves, B.; Goniche, M.; Goodliffe, M.; Goodyear, A.; Gorini, G.; Gosk, M.; Goulding, R.; Goussarov, A.; Gowland, R.; Graham, B.; Graham, M. E.; Graves, J. P.; Grazier, N.; Grazier, P.; Green, N. R.; Greuner, H.; Grierson, B.; Griph, F. S.; Grisolia, C.; Grist, D.; Groth, M.; Grove, R.; Grundy, C. N.; Grzonka, J.; Guard, D.; Guérard, C.; Guillemaut, C.; Guirlet, R.; Gurl, C.; Utoh, H. H.; Hackett, L. J.; Hacquin, S.; Hagar, A.; Hager, R.; Hakola, A.; Halitovs, M.; Hall, S. J.; Cook, S. P. Hallworth; Hamlyn-Harris, C.; Hammond, K.; Harrington, C.; Harrison, J.; Harting, D.; Hasenbeck, F.; Hatano, Y.; Hatch, D. R.; Haupt, T. D. V.; Hawes, J.; Hawkes, N. C.; Hawkins, J.; Hawkins, P.; Haydon, P. W.; Hayter, N.; Hazel, S.; Heesterman, P. J. L.; Heinola, K.; Hellesen, C.; Hellsten, T.; Helou, W.; Hemming, O. N.; Hender, T. C.; Henderson, M.; Henderson, S. S.; Henriques, R.; Hepple, D.; Hermon, G.; Hertout, P.; Hidalgo, C.; Highcock, E. G.; Hill, M.; Hillairet, J.; Hillesheim, J.; Hillis, D.; Hizanidis, K.; Hjalmarsson, A.; Hobirk, J.; Hodille, E.; Hogben, C. H. A.; Hogeweij, G. M. D.; Hollingsworth, A.; Hollis, S.; Homfray, D. A.; Horáček, J.; Hornung, G.; Horton, A. R.; Horton, L. D.; Horvath, L.; Hotchin, S. P.; Hough, M. R.; Howarth, P. J.; Hubbard, A.; Huber, A.; Huber, V.; Huddleston, T. M.; Hughes, M.; Huijsmans, G. T. A.; Hunter, C. L.; Huynh, P.; Hynes, A. M.; Iglesias, D.; Imazawa, N.; Imbeaux, F.; Imríšek, M.; Incelli, M.; Innocente, P.; Irishkin, M.; Ivanova-Stanik, I.; Jachmich, S.; Jacobsen, A. S.; Jacquet, P.; Jansons, J.; Jardin, A.; Järvinen, A.; Jaulmes, F.; Jednoróg, S.; Jenkins, I.; Jeong, C.; Jepu, I.; Joffrin, E.; Johnson, R.; Johnson, T.; Johnston, Jane; Joita, L.; Jones, G.; Jones, T. T. C.; Hoshino, K. K.; Kallenbach, A.; Kamiya, K.; Kaniewski, J.; Kantor, A.; Kappatou, A.; Karhunen, J.; Karkinsky, D.; Karnowska, I.; Kaufman, M.; Kaveney, G.; Kazakov, Y.; Kazantzidis, V.; Keeling, D. L.; Keenan, T.; Keep, J.; Kempenaars, M.; Kennedy, C.; Kenny, D.; Kent, J.; Kent, O. N.; Khilkevich, E.; Kim, H. T.; Kim, H. S.; Kinch, A.; King, C.; King, D.; King, R. F.; Kinna, D. J.; Kiptily, V.; Kirk, A.; Kirov, K.; Kirschner, A.; Kizane, G.; Klepper, C.; Klix, A.; Knight, P.; Knipe, S. J.; Knott, S.; Kobuchi, T.; Köchl, F.; Kocsis, G.; Kodeli, I.; Kogan, L.; Kogut, D.; Koivuranta, S.; Kominis, Y.; Köppen, M.; Kos, B.; Koskela, T.; Koslowski, H. R.; Koubiti, M.; Kovari, M.; Kowalska-Strzęciwilk, E.; Krasilnikov, A.; Krasilnikov, V.; Krawczyk, N.; Kresina, M.; Krieger, K.; Krivska, A.; Kruezi, U.; Książek, I.; Kukushkin, A.; Kundu, A.; Kurki-Suonio, T.; Kwak, S.; Kwiatkowski, R.; Kwon, O. J.; Laguardia, L.; Lahtinen, A.; Laing, A.; Lam, N.; Lambertz, H. T.; Lane, C.; Lang, P. T.; Lanthaler, S.; Lapins, J.; Lasa, A.; Last, J. R.; Łaszyńska, E.; Lawless, R.; Lawson, A.; Lawson, K. D.; Lazaros, A.; Lazzaro, E.; Leddy, J.; Lee, S.; Lefebvre, X.; Leggate, H. J.; Lehmann, J.; Lehnen, M.; Leichtle, D.; Leichuer, P.; Leipold, F.; Lengar, I.; Lennholm, M.; Lerche, E.; Lescinskis, A.; Lesnoj, S.; Letellier, E.; Leyland, M.; Leysen, W.; Li, L.; Liang, Y.; Likonen, J.; Linke, J.; Linsmeier, Ch.; Lipschultz, B.; Litaudon, X.; Liu, G.; Liu, Y.; Lo Schiavo, V. P.; Loarer, T.; Loarte, A.; Lobel, R. C.; Lomanowski, B.; Lomas, P. J.; Lönnroth, J.; López, J. M.; López-Razola, J.; Lorenzini, R.; Losada, U.; Lovell, J. J.; Loving, A. B.; Lowry, C.; Luce, T.; Lucock, R. M. A.; Lukin, A.; Luna, C.; Lungaroni, M.; Lungu, C. P.; Lungu, M.; Lunniss, A.; Lupelli, I.; Lyssoivan, A.; MacDonald, N.; Macheta, P.; Maczewa, K.; Magesh, B.; Maget, P.; Maggi, C.; Maier, H.; Mailloux, J.; Makkonen, T.; Makwana, R.; Malaquias, A.; Malizia, A.; Manas, P.; Manning, A.; Manso, M. E.; Mantica, P.; Mantsinen, M.; Manzanares, A.; Maquet, Ph.; Marandet, Y.; Marcenko, N.; Marchetto, C.; Marchuk, O.; Marinelli, M.; Marinucci, M.; Markovič, T.; Marocco, D.; Marot, L.; Marren, C. A.; Marshal, R.; Martin, A.; Martin, Y.; Martín de Aguilera, A.; Martínez, F. J.; Martín-Solís, J. R.; Martynova, Y.; Maruyama, S.; Masiello, A.; Maslov, M.; Matejcik, S.; Mattei, M.; Matthews, G. F.; Maviglia, F.; Mayer, M.; Mayoral, M. L.; May-Smith, T.; Mazon, D.; Mazzotta, C.; McAdams, R.; McCarthy, P. J.; McClements, K. G.; McCormack, O.; McCullen, P. A.; McDonald, D.; McIntosh, S.; McKean, R.; McKehon, J.; Meadows, R. C.; Meakins, A.; Medina, F.; Medland, M.; Medley, S.; Meigh, S.; Meigs, A. G.; Meisl, G.; Meitner, S.; Meneses, L.; Menmuir, S.; Mergia, K.; Merrigan, I. R.; Mertens, Ph.; Meshchaninov, S.; Messiaen, A.; Meyer, H.; Mianowski, S.; Michling, R.; Middleton-Gear, D.; Miettunen, J.; Militello, F.; Militello-Asp, E.; Miloshevsky, G.; Mink, F.; Minucci, S.; Miyoshi, Y.; Mlynář, J.; Molina, D.; Monakhov, I.; Moneti, M.; Mooney, R.; Moradi, S.; Mordijck, S.; Moreira, L.; Moreno, R.; Moro, F.; Morris, A. W.; Morris, J.; Moser, L.; Mosher, S.; Moulton, D.; Murari, A.; Muraro, A.; Murphy, S.; Asakura, N. N.; Na, Y. S.; Nabais, F.; Naish, R.; Nakano, T.; Nardon, E.; Naulin, V.; Nave, M. F. F.; Nedzelski, I.; Nemtsev, G.; Nespoli, F.; Neto, A.; Neu, R.; Neverov, V. S.; Newman, M.; Nicholls, K. J.; Nicolas, T.; Nielsen, A. H.; Nielsen, P.; Nilsson, E.; Nishijima, D.; Noble, C.; Nocente, M.; Nodwell, D.; Nordlund, K.; Nordman, H.; Nouailletas, R.; Nunes, I.; Oberkofler, M.; Odupitan, T.; Ogawa, M. T.; O'Gorman, T.; Okabayashi, M.; Olney, R.; Omolayo, O.; O'Mullane, M.; Ongena, J.; Orsitto, F.; Orszagh, J.; Oswuigwe, B. I.; Otin, R.; Owen, A.; Paccagnella, R.; Pace, N.; Pacella, D.; Packer, L. W.; Page, A.; Pajuste, E.; Palazzo, S.; Pamela, S.; Panja, S.; Papp, P.; Paprok, R.; Parail, V.; Park, M.; Diaz, F. Parra; Parsons, M.; Pasqualotto, R.; Patel, A.; Pathak, S.; Paton, D.; Patten, H.; Pau, A.; Pawelec, E.; Soldan, C. Paz; Peackoc, A.; Pearson, I. J.; Pehkonen, S.-P.; Peluso, E.; Penot, C.; Pereira, A.; Pereira, R.; Puglia, P. P. Pereira; von Thun, C. Perez; Peruzzo, S.; Peschanyi, S.; Peterka, M.; Petersson, P.; Petravich, G.; Petre, A.; Petrella, N.; Petržilka, V.; Peysson, Y.; Pfefferlé, D.; Philipps, V.; Pillon, M.; Pintsuk, G.; Piovesan, P.; Dos Reis, A. Pires; Piron, L.; Pironti, A.; Pisano; Pitts, R.; Pizzo, F.; Plyusnin, V.; Pomaro, N.; Pompilian, O. G.; Pool, P. J.; Popovichev, S.; Porfiri, M. T.; Porosnicu, C.; Porton, M.; Possnert, G.; Potzel, S.; Powell, T.; Pozzi, J.; Prajapati, V.; Prakash, R.; Prestopino, G.; Price, D.; Price, M.; Price, R.; Prior, P.; Proudfoot, R.; Pucella, G.; Puglia, P.; Puiatti, M. E.; Pulley, D.; Purahoo, K.; Pütterich, Th.; Rachlew, E.; Rack, M.; Ragona, R.; Rainford, M. S. J.; Rakha, A.; Ramogida, G.; Ranjan, S.; Rapson, C. J.; Rasmussen, J. J.; Rathod, K.; Rattá, G.; Ratynskaia, S.; Ravera, G.; Rayner, C.; Rebai, M.; Reece, D.; Reed, A.; Réfy, D.; Regan, B.; Regaña, J.; Reich, M.; Reid, N.; Reimold, F.; Reinhart, M.; Reinke, M.; Reiser, D.; Rendell, D.; Reux, C.; Cortes, S. D. A. Reyes; Reynolds, S.; Riccardo, V.; Richardson, N.; Riddle, K.; Rigamonti, D.; Rimini, F. G.; Risner, J.; Riva, M.; Roach, C.; Robins, R. J.; Robinson, S. A.; Robinson, T.; Robson, D. W.; Roccella, R.; Rodionov, R.; Rodrigues, P.; Rodriguez, J.; Rohde, V.; Romanelli, F.; Romanelli, M.; Romanelli, S.; Romazanov, J.; Rowe, S.; Rubel, M.; Rubinacci, G.; Rubino, G.; Ruchko, L.; Ruiz, M.; Ruset, C.; Rzadkiewicz, J.; Saarelma, S.; Sabot, R.; Safi, E.; Sagar, P.; Saibene, G.; Saint-Laurent, F.; Salewski, M.; Salmi, A.; Salmon, R.; Salzedas, F.; Samaddar, D.; Samm, U.; Sandiford, D.; Santa, P.; Santala, M. I. K.; Santos, B.; Santucci, A.; Sartori, F.; Sartori, R.; Sauter, O.; Scannell, R.; Schlummer, T.; Schmid, K.; Schmidt, V.; Schmuck, S.; Schneider, M.; Schöpf, K.; Schwörer, D.; Scott, S. D.; Sergienko, G.; Sertoli, M.; Shabbir, A.; Sharapov, S. E.; Shaw, A.; Shaw, R.; Sheikh, H.; Shepherd, A.; Shevelev, A.; Shumack, A.; Sias, G.; Sibbald, M.; Sieglin, B.; Silburn, S.; Silva, A.; Silva, C.; Simmons, P. A.; Simpson, J.; Simpson-Hutchinson, J.; Sinha, A.; Sipilä, S. K.; Sips, A. C. C.; Sirén, P.; Sirinelli, A.; Sjöstrand, H.; Skiba, M.; Skilton, R.; Slabkowska, K.; Slade, B.; Smith, N.; Smith, P. G.; Smith, R.; Smith, T. J.; Smithies, M.; Snoj, L.; Soare, S.; Solano, E. R.; Somers, A.; Sommariva, C.; Sonato, P.; Sopplesa, A.; Sousa, J.; Sozzi, C.; Spagnolo, S.; Spelzini, T.; Spineanu, F.; Stables, G.; Stamatelatos, I.; Stamp, M. F.; Staniec, P.; Stankūnas, G.; Stan-Sion, C.; Stead, M. J.; Stefanikova, E.; Stepanov, I.; Stephen, A. V.; Stephen, M.; Stevens, A.; Stevens, B. D.; Strachan, J.; Strand, P.; Strauss, H. R.; Ström, P.; Stubbs, G.; Studholme, W.; Subba, F.; Summers, H. P.; Svensson, J.; Świderski, Ł.; Szabolics, T.; Szawlowski, M.; Szepesi, G.; Suzuki, T. T.; Tál, B.; Tala, T.; Talbot, A. R.; Talebzadeh, S.; Taliercio, C.; Tamain, P.; Tame, C.; Tang, W.; Tardocchi, M.; Taroni, L.; Taylor, D.; Taylor, K. A.; Tegnered, D.; Telesca, G.; Teplova, N.; Terranova, D.; Testa, D.; Tholerus, E.; Thomas, J.; Thomas, J. D.; Thomas, P.; Thompson, A.; Thompson, C.-A.; Thompson, V. K.; Thorne, L.; Thornton, A.; Thrysøe, A. S.; Tigwell, P. A.; Tipton, N.; Tiseanu, I.; Tojo, H.; Tokitani, M.; Tolias, P.; Tomeš, M.; Tonner, P.; Towndrow, M.; Trimble, P.; Tripsky, M.; Tsalas, M.; Tsavalas, P.; Jun, D. Tskhakaya; Turner, I.; Turner, M. M.; Turnyanskiy, M.; Tvalashvili, G.; Tyrrell, S. G. J.; Uccello, A.; Ul-Abidin, Z.; Uljanovs, J.; Ulyatt, D.; Urano, H.; Uytdenhouwen, I.; Vadgama, A. P.; Valcarcel, D.; Valentinuzzi, M.; Valisa, M.; Olivares, P. Vallejos; Valovic, M.; van de Mortel, M.; van Eester, D.; van Renterghem, W.; van Rooij, G. J.; Varje, J.; Varoutis, S.; Vartanian, S.; Vasava, K.; Vasilopoulou, T.; Vega, J.; Verdoolaege, G.; Verhoeven, R.; Verona, C.; Rinati, G. Verona; Veshchev, E.; Vianello, N.; Vicente, J.; Viezzer, E.; Villari, S.; Villone, F.; Vincenzi, P.; Vinyar, I.; Viola, B.; Vitins, A.; Vizvary, Z.; Vlad, M.; Voitsekhovitch, I.; Vondráček, P.; Vora, N.; Vu, T.; de Sa, W. W. Pires; Wakeling, B.; Waldon, C. W. F.; Walkden, N.; Walker, M.; Walker, R.; Walsh, M.; Wang, E.; Wang, N.; Warder, S.; Warren, R. J.; Waterhouse, J.; Watkins, N. W.; Watts, C.; Wauters, T.; Weckmann, A.; Weiland, J.; Weisen, H.; Weiszflog, M.; Wellstood, C.; West, A. T.; Wheatley, M. R.; Whetham, S.; Whitehead, A. M.; Whitehead, B. D.; Widdowson, A. M.; Wiesen, S.; Wilkinson, J.; Williams, J.; Williams, M.; Wilson, A. R.; Wilson, D. J.; Wilson, H. R.; Wilson, J.; Wischmeier, M.; Withenshaw, G.; Withycombe, A.; Witts, D. M.; Wood, D.; Wood, R.; Woodley, C.; Wray, S.; Wright, J.; Wright, J. C.; Wu, J.; Wukitch, S.; Wynn, A.; Xu, T.; Yadikin, D.; Yanling, W.; Yao, L.; Yavorskij, V.; Yoo, M. G.; Young, C.; Young, D.; Young, I. D.; Young, R.; Zacks, J.; Zagorski, R.; Zaitsev, F. S.; Zanino, R.; Zarins, A.; Zastrow, K. D.; Zerbini, M.; Zhang, W.; Zhou, Y.; Zilli, E.; Zoita, V.; Zoletnik, S.; Zychor, I.

2017-10-01

We describe a new technique for the efficient generation of high-energy ions with electromagnetic ion cyclotron waves in multi-ion plasmas. The discussed `three-ion' scenarios are especially suited for strong wave absorption by a very low number of resonant ions. To observe this effect, the plasma composition has to be properly adjusted, as prescribed by theory. We demonstrate the potential of the method on the world-largest plasma magnetic confinement device, JET (Joint European Torus, Culham, UK), and the high-magnetic-field tokamak Alcator C-Mod (Cambridge, USA). The obtained results demonstrate efficient acceleration of 3He ions to high energies in dedicated hydrogen-deuterium mixtures. Simultaneously, effective plasma heating is observed, as a result of the slowing-down of the fast 3He ions. The developed technique is not only limited to laboratory plasmas, but can also be applied to explain observations of energetic ions in space-plasma environments, in particular, 3He-rich solar flares.

Evaluation of procoagulant tissue factor expression in canine hemangiosarcoma cell lines.

PubMed

Witter, Lauren E; Gruber, Erika J; Lean, Fabian Z X; Stokol, Tracy

2017-01-01

OBJECTIVE To evaluate expression of procoagulant tissue factor (TF) by canine hemangiosarcoma cells in vitro. SAMPLES 4 canine hemangiosarcoma cell lines (SB-HSA [mouse-passaged cutaneous tumor], Emma [primary metastatic brain tumor], and Frog and Dal-1 [primary splenic tumors]) and 1 nonneoplastic canine endothelial cell line (CnAoEC). PROCEDURES TF mRNA and TF antigen expression were evaluated by quantitative real-time PCR assay and flow cytometry, respectively. Thrombin generation was measured in canine plasma and in coagulation factor-replete or specific coagulation factor-deficient human plasma by calibrated automated thrombography. Corn trypsin inhibitor and annexin V were used to examine contributions of contact activation and membrane-bound phosphatidylserine, respectively, to thrombin generation. RESULTS All cell lines expressed TF mRNA and antigen, with significantly greater expression of both products in SB-HSA and Emma cells than in CnAoEC. A greater percentage of SB-HSA cells expressed TF antigen, compared with other hemangiosarcoma cell lines. All hemangiosarcoma cell lines generated significantly more thrombin than did CnAoEC in canine or factor-replete human plasma. Thrombin generation induced by SB-HSA cells was significantly lower in factor VII-deficient plasma than in factor-replete plasma and was abolished in factor X-deficient plasma; residual thrombin generation in factor VII-deficient plasma was abolished by incubation of cells with annexin V. Thrombin generation by SB-HSA cells was unaffected by the addition of corn trypsin inhibitor. CONCLUSIONS AND CLINICAL RELEVANCE Hemangiosarcoma cell lines expressed procoagulant TF in vitro. Further research is needed to determine whether TF can be used as a biomarker for hemostatic dysfunction in dogs with hemangiosarcoma.

Generation of disc-like plasma from laser-matter interaction in the presence of a strong external magnetic field

NASA Astrophysics Data System (ADS)

Ivanov, V. V.; Maximov, A. V.; Betti, R.; Wiewior, P. P.; Hakel, P.; Sherrill, M. E.

2017-08-01

Dynamics of laser produced plasma in a strong magnetic field was studied using a 1 MA pulsed power generator coupled to an intense, high-energy laser. A 2-2.5 MG magnetic field was generated on the surface of a rod load 0.8-1.2 mm in diameter. A sub-nanosecond laser pulse with intensity of 3 × 1015 W cm-2 was focused on the rod load surface. Side-on laser diagnostics showed the generation of two collimated jets 1-3 mm long on the front and rear sides of the load. End-on laser diagnostics reveal that the laser produced plasma in the MG magnetic field takes the form of a thin disc as the plasma propagates along the magnetic field lines. The disc-like plasma expands radially across the magnetic field with a velocity of 250 km s-1. An electron temperature of 400 eV was measured in the laser-produced plasma on the rod load.

Specular Reflectivity and Hot-Electron Generation in High-Contrast Relativistic Laser-Plasma Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kemp, Gregory Elijah

2013-01-01

Ultra-intense laser (> 1018 W/cm2) interactions with matter are capable of producing relativistic electrons which have a variety of applications in state-of-the-art scientific and medical research conducted at universities and national laboratories across the world. Control of various aspects of these hot-electron distributions is highly desired to optimize a particular outcome. Hot-electron generation in low-contrast interactions, where significant amounts of under-dense pre-plasma are present, can be plagued by highly non-linear relativistic laser-plasma instabilities and quasi-static magnetic field generation, often resulting in less than desirable and predictable electron source characteristics. High-contrast interactions offer more controlled interactions but often at the costmore » of overall lower coupling and increased sensitivity to initial target conditions. An experiment studying the differences in hot-electron generation between high and low-contrast pulse interactions with solid density targets was performed on the Titan laser platform at the Jupiter Laser Facility at Lawrence Livermore National Laboratory in Livermore, CA. To date, these hot-electrons generated in the laboratory are not directly observable at the source of the interaction. Instead, indirect studies are performed using state-of-the-art simulations, constrained by the various experimental measurements. These measurements, more-often-than-not, rely on secondary processes generated by the transport of these electrons through the solid density materials which can susceptible to a variety instabilities and target material/geometry effects. Although often neglected in these types of studies, the specularly reflected light can provide invaluable insight as it is directly influenced by the interaction. In this thesis, I address the use of (personally obtained) experimental specular reflectivity measurements to indirectly study hot-electron generation in the context of high

Plasma Generated Spherules

NASA Astrophysics Data System (ADS)

Ransom, C. J.

2005-04-01

Z-pinch plasma simulations have been performed that indicate the production of spherules under certain experimental parameters. (A. L. Peratt, private communication) While performing experiments dealing with the impact of plasma discharges on various materials, we observed that spherules were created at the surface of some of the materials. For specific materials and conditions, spherules were always produced. Both individual spherules and joined spherules were created. The size and shapes were nearly identical to items found by the Mars rover, Opportunity, and called ``blueberries.'' Sky & Telescope, June 2004, p. 20, among other sources indicated the blueberries were gray spherules composed of hematite. The experiments produced hematite spherules identical in appearance to those found on Mars. These experiments suggest how the newly discovered blueberries were formed on Mars while providing an explanation that does not depend on the presence of water.

Demonstration of multi-generational growth of tungsten nanoparticles in hydrogen plasma using in situ laser extinction method

NASA Astrophysics Data System (ADS)

Ouaras, K.; Lombardi, G.; Hassouni, K.

2018-03-01

For the first time, we demonstrate that tungsten (W) nanoparticles (NPs) are created when a tungsten target is exposed to low-pressure, high density hydrogen plasma. The plasma was generated using a novel dual plasma system combining a microwave discharge and a pulsed direct-current (DC) discharge. The tungsten surface originates in the multi-generational formation of a significant population of 30-70 nm diameter particles when the W cathode is biased at ~  -1 kV and submitted to ~1020 m2 s-1 H+/H2+ /H3+ ions flux. The evidenced NPs formation should be taking into account as one of the consequence of the plasma surface interaction outcomes, especially for fusion applications.

Generation and confinement of microwave gas-plasma in photonic dielectric microstructure.

PubMed

Debord, B; Jamier, R; Gérôme, F; Leroy, O; Boisse-Laporte, C; Leprince, P; Alves, L L; Benabid, F

2013-10-21

We report on a self-guided microwave surface-wave induced generation of ~60 μm diameter and 6 cm-long column of argon-plasma confined in the core of a hollow-core photonic crystal fiber. At gas pressure of 1 mbar, the micro-confined plasma exhibits a stable transverse profile with a maximum gas-temperature as high as 1300 ± 200 K, and a wall-temperature as low as 500 K, and an electron density level of 10¹⁴ cm⁻³. The fiber guided fluorescence emission presents strong Ar⁺ spectral lines in the visible and near UV. Theory shows that the observed combination of relatively low wall-temperature and high ionisation rate in this strongly confined configuration is due to an unprecedentedly wide electrostatic space-charge field and the subsequent ion acceleration dominance in the plasma-to-gas power transfer.

Phase-matched second- and third-harmonic generation in plasmas with density ripple

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dahiya, Deepak; Sajal, Vivek; Sharma, A. K.

The generation of second and third harmonics by the interaction of an ultrashort laser pulse with underdense plasma having a density ripple is studied at intensities I{lambda}{sup 2}=10{sup 16}-10{sup 19} W cm{sup -2} {mu}m{sup 2} using fully relativistic two-dimensional particle-in-cell simulations with high spectral resolution. A theoretical model is developed for second- and third-harmonic conversion efficiencies. When the laser is plane polarized in the simulation plane even and odd harmonics are excited in the same polarization as the laser polarization. The highest efficiency of generation of a specific harmonic occurs when the ripple wave vector value k{sub q} satisfies phase-matchingmore » conditions. The efficiency of phase-matched harmonic generation is an order of magnitude higher than the one without phase matching. The efficiency increases rapidly in weak and moderate relativistic regime and tends to saturate in strong relativistic regime. At moderately relativistic intensities and low plasma densities, the simulation and recent experimental results are fairly reproduced by an analytical theory.« less

Plasma Motor Generator (PMG) electrodynamic tether experiment

NASA Technical Reports Server (NTRS)

Grossi, Mario D.

1995-01-01

The Plasma Motor Generator (PMG) flight of June 26, 1993 has been the most sophisticated and most successful mission that has been carried out thus far with an electrodynamic tether. Three papers from the Smithsonian Astrophysical Observatory, Washington, DC concerned with the PMG, submitted at the Fourth International Space Conference on Tethers in Space, in Washington, DC, in April 1995, are contained in this document. The three papers are (1) Electromagnetic interactions between the PMG tether and the magneto-ionic medium of the Ionosphere; (2) Tether-current-voltage characteristics, as determined by the Hollow Cathode Operation Modes; and (3) Hawaii-Hilo ground observations on the occasion for the PMG flight of June 23, 1993.

Megawatt low-temperature DC plasma generator with divergent channels of gas-discharge tract

NASA Astrophysics Data System (ADS)

Gadzhiev, M. Kh.; Isakaev, E. Kh.; Tyuftyaev, A. S.; Yusupov, D. I.; Sargsyan, M. A.

2017-04-01

We have developed and studied a new effective megawatt double-unit generator of low-temperature argon plasma, which belongs to the class of dc plasmatrons and comprises the cathode and anode units with divergent gas-discharge channels. The generator has an efficiency of about 80-85% and ensures a long working life at operating currents up to 4000 A.

Promoting Plasma Physics as a Career: A Generational Approach

NASA Astrophysics Data System (ADS)

Morgan, James

2005-10-01

A paradigm shift is occurring in education physics programs. Educators are shifting from the traditional teaching focus to concentrate on student learning. Students are unaware of physics as a career, plasma physics or the job opportunities afforded to them with a physics degree. The physics profession needs to promote itself to the younger generations, or specifically the millennial generation (Born in the 1980's-2000's). Learning styles preferred by ``Millennials'' include a technological environment that promotes learning through active task performance rather than passive attendance at lectures. Millennials respond well to anything experiential and will be motivated by opportunities for creativity and challenging learning environments. The open-ended access to information, the ability to tailor learning paths, and continuous and instantaneous performance assessment offer flexibility in the design of curricula as well as in the method of delivery. Educators need to understand the millennial generation, appeal to their motivations and offer a learning environment designed for their learning style. This poster suggests promoting a physics career by focusing on generational learning styles and preferences.

Control of Reactive Species Generated by Low-frequency Biased Nanosecond Pulse Discharge in Atmospheric Pressure Plasma Effluent

NASA Astrophysics Data System (ADS)

Takashima, Keisuke; Kaneko, Toshiro

2016-09-01

The control of hydroxyl radical and the other gas phase species generation in the ejected gas through air plasma (air plasma effluent) has been experimentally studied, which is a key to extend the range of plasma treatment. Nanosecond pulse discharge is known to produce high reduced electric field (E/N) discharge that leads to efficient generation of the reactive species than conventional low frequency discharge, while the charge-voltage cycle in the low frequency discharge is known to be well-controlled. In this study, the nanosecond pulse discharge biased with AC low frequency high voltage is used to take advantages of these discharges, which allows us to modulate the reactive species composition in the air plasma effluent. The utilization of the gas-liquid interface and the liquid phase chemical reactions between the modulated long-lived reactive species delivered from the air plasma effluent could realize efficient liquid phase chemical reactions leading to short-lived reactive species production far from the air plasma, which is crucial for some plasma agricultural applications.

Astrophysics of magnetically collimated jets generated from laser-produced plasmas.

PubMed

Ciardi, A; Vinci, T; Fuchs, J; Albertazzi, B; Riconda, C; Pépin, H; Portugall, O

2013-01-11

The generation of astrophysically relevant jets, from magnetically collimated, laser-produced plasmas, is investigated through three-dimensional, magnetohydrodynamic simulations. We show that for laser intensities I∼10(12)-10(14) W cm(-2), a magnetic field in excess of ∼0.1  MG, can collimate the plasma plume into a prolate cavity bounded by a shock envelope with a standing conical shock at its tip, which recollimates the flow into a supermagnetosonic jet beam. This mechanism is equivalent to astrophysical models of hydrodynamic inertial collimation, where an isotropic wind is focused into a jet by a confining circumstellar toruslike envelope. The results suggest an alternative mechanism for a large-scale magnetic field to produce jets from wide-angle winds.

Mitigation of Hot Electrons from Laser-Plasma Instabilities in Laser-Generated X-Ray Sources

NASA Astrophysics Data System (ADS)

Fein, Jeffrey R.

This thesis describes experiments to understand and mitigate energetic or "hot" electrons from laser-plasma instabilities (LPIs) in an effort to improve radiographic techniques using laser-generated x-ray sources. Initial experiments on the OMEGA-60 laser show evidence of an underlying background generated by x-rays with energies over 10 keV on radiographs using backlit pinhole radiography, whose source is consistent with hard x-rays from LPI-generated hot electrons. Mitigating this background can dramatically reduce uncertainties in measured object densities from radiographs and may be achieved by eliminating the target components in which LPIs are most likely to grow. Experiments were performed on the OMEGA-EP laser to study hot electron production from laser-plasma instabilities in high-Z plasmas relevant to laser-generated x-ray sources. Measurements of hard x-rays show a dramatic reduction in hot-electron energy going from low-Z CH to high-Z Au targets, in a manner that is consistent with steepening electron density profiles that were also measured. The profile-steepening, we infer, increased thresholds of LPIs and contributed to the reduced hot-electron production at higher Z. Possible mechanisms for generating hot electrons include the two-plasmon decay and stimulated Raman scattering instabilities driven by multiple laser beams. Radiation hydrodynamic simulations using the CRASH code predict that both of these instabilities were above threshold with linear threshold parameters that decreased with increasing Z due to steepening length-scales, as well as enhanced laser absorption and increased collisional and Landau damping of electron plasma waves. Another set of experiments were performed on the OMEGA-60 laser to test whether hard x-ray background could be mitigated in backlit pinhole imagers by controlling laser-plasma instabilities. Based on the results above, we hypothesized that LPIs and hot electrons that lead to hard x-ray background would be reduced

Platelet-rich plasma stimulated by pulse electric fields: Platelet activation, procoagulant markers, growth factor release and cell proliferation.

PubMed

Frelinger, A L; Torres, A S; Caiafa, A; Morton, C A; Berny-Lang, M A; Gerrits, A J; Carmichael, S L; Neculaes, V B; Michelson, A D

2016-01-01

Therapeutic use of activated platelet-rich plasma (PRP) has been explored for wound healing, hemostasis and antimicrobial wound applications. Pulse electric field (PEF) stimulation may provide more consistent platelet activation and avoid complications associated with the addition of bovine thrombin, the current state of the art ex vivo activator of therapeutic PRP. The aim of this study was to compare the ability of PEF, bovine thrombin and thrombin receptor activating peptide (TRAP) to activate human PRP, release growth factors and induce cell proliferation in vitro. Human PRP was prepared in the Harvest SmartPreP2 System and treated with vehicle, PEF, bovine thrombin, TRAP or Triton X-100. Platelet activation and procoagulant markers and microparticle generation were measured by flow cytometry. Released growth factors were measured by ELISA. The releasates were tested for their ability to stimulate proliferation of human epithelial cells in culture. PEF produced more platelet-derived microparticles, P-selectin-positive particles and procoagulant annexin V-positive particles than bovine thrombin or TRAP. These differences were associated with higher levels of released epidermal growth factor after PEF than after bovine thrombin or TRAP but similar levels of platelet-derived, vascular-endothelial, and basic fibroblast growth factors, and platelet factor 4. Supernatant from PEF-treated platelets significantly increased cell proliferation compared to plasma. In conclusion, PEF treatment of fresh PRP results in generation of microparticles, exposure of prothrombotic platelet surfaces, differential release of growth factors compared to bovine thrombin and TRAP and significant cell proliferation. These results, together with PEF's inherent advantages, suggest that PEF may be a superior alternative to bovine thrombin activation of PRP for therapeutic applications.

Cylindrical neutron generator

DOEpatents

Leung, Ka-Ngo [Hercules, CA

2008-04-22

A cylindrical neutron generator is formed with a coaxial RF-driven plasma ion source and target. A deuterium (or deuterium and tritium) plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical neutron generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which contain many slots. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. The plasma generator may be in the center and the neutron target on the outside, or the plasma generator may be on the outside and the target on the inside. In a nested configuration, several concentric targets and plasma generating regions are nested to increase the neutron flux.

Cylindrical neutron generator

DOEpatents

Leung, Ka-Ngo

2005-06-14

A cylindrical neutron generator is formed with a coaxial RF-driven plasma ion source and target. A deuterium (or deuterium and tritium) plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical neutron generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which contain many slots. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. The plasma generator may be in the center and the neutron target on the outside, or the plasma generator may be on the outside and the target on the inside. In a nested configuration, several concentric targets and plasma generating regions are nested to increase the neutron flux.

Cylindrical neutron generator

DOEpatents

Leung, Ka-Ngo [Hercules, CA

2009-12-29

A cylindrical neutron generator is formed with a coaxial RF-driven plasma ion source and target. A deuterium (or deuterium and tritium) plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical neutron generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which contain many slots. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. The plasma generator may be in the center and the neutron target on the outside, or the plasma generator may be on the outside and the target on the inside. In a nested configuration, several concentric targets and plasma generating regions are nested to increase the neutron flux.

Contact Geometry and Distribution of Plasma Generated in the Vicinity of Sliding Contact

NASA Astrophysics Data System (ADS)

Nakayama, Keiji

2007-09-01

The effect of the geometry of the smaller sliding partner on plasma (triboplasma) generation has been investigated as a function of the tip radius of a diamond pin, which slides against a single crystal sapphire disk under atmospheric dry air pressure. It was found that the diameter and the total intensity of the circular triboplasma increase parabolically with an increase in the tip radius of the pin under constant normal force and sliding velocity. The plasma is most intense at the crossing point of the plasma ring and the frictional track in the plasma circle. The gap distance at the crossing point is independent of the tip radius. The ring diameter increases with an increase in the tip radius, keeping the gap distance constant and obeying Paschen’s law of gas discharge.

Generation of Low-Energy High-Current Electron Beams in Plasma-Anode Electron Guns

NASA Astrophysics Data System (ADS)

Ozur, G. E.; Proskurovsky, D. I.

2018-01-01

This paper is a review of studies on the generation of low-energy high-current electron beams in electron guns with a plasma anode and an explosive-emission cathode. The problems related to the initiation of explosive electron emission under plasma and the formation and transport of high-current electron beams in plasma-filled systems are discussed consecutively. Considerable attention is given to the nonstationary effects that occur in the space charge layers of plasma. Emphasis is also placed on the problem of providing a uniform energy density distribution over the beam cross section, which is of critical importance in using electron beams of this type for surface treatment of materials. Examples of facilities based on low-energy high-current electron beam sources are presented and their applications in materials science and practice are discussed.

Spontaneous Generation of a Sheared Plasma Rotation in a Field-Reversed θ-Pinch Discharge

NASA Astrophysics Data System (ADS)

Omelchenko, Y. A.; Karimabadi, H.

2012-08-01

By conducting two-dimensional hybrid simulations of an infinitely long field-reversed θ-pinch discharge we discover a new type of plasma rotation, which rapidly develops at the plasma edge in the ion diamagnetic direction due to the self-consistent generation of a Hall-driven radial electric field. This effect is different from the previously identified end-shorting and particle-loss mechanisms. We also demonstrate flutelike perturbations frequently inferred in experiments and show that in the absence of axial contraction effects they may quickly alter the toroidal symmetry of the plasma.

Baryon inhomogeneity generation in the quark-gluon plasma phase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Layek, Biswanath; Mishra, Ananta P.; Srivastava, Ajit M.

2006-05-15

We discuss the possibility of generation of baryon inhomogeneities in a quark-gluon plasma phase due to moving Z(3) interfaces. By modeling the dependence of effective mass of the quarks on the Polyakov loop order parameter, we study the reflection of quarks from collapsing Z(3) interfaces and estimate resulting baryon inhomogeneities in the context of the early universe. We argue that in the context of certain low energy scale inflationary models, it is possible that large Z(3) walls arise at the end of the reheating stage. Collapse of such walls could lead to baryon inhomogeneities which may be separated by largemore » distances near the QCD scale. Importantly, the generation of these inhomogeneities is insensitive to the order, or even the existence, of the quark-hadron phase transition. We also briefly discuss the possibility of formation of quark nuggets in this model, as well as baryon inhomogeneity generation in relativistic heavy-ion collisions.« less

The Tethered Balloon Current Generator - A space shuttle-tethered subsatellite for plasma studies and power generation

NASA Technical Reports Server (NTRS)

Williamson, P. R.; Banks, P. M.

1976-01-01

The objectives of the Tethered Balloon Current Generator experiment are to: (1) generate relatively large regions of thermalized, field-aligned currents, (2) produce controlled-amplitude Alfven waves, (3) study current-driven electrostatic plasma instabilities, and (4) generate substantial amounts of power or propulsion through the MHD interaction. A large balloon (a diameter of about 30 m) will be deployed with a conducting surface above the space shuttle at a distance of about 10 km. For a generally eastward directed orbit at an altitude near 400 km, the balloon, connected to the shuttle by a conducting wire, will be positive with respect to the shuttle, enabling it to collect electrons. At the same time, the shuttle will collect positive ions and, upon command, emit an electron beam to vary current flow in the system.

Study on THz wave generation from air plasma induced by quasi-square Airy beam

NASA Astrophysics Data System (ADS)

Zhang, Shijing; Zhang, Liangliang; Jiang, Guangtong; Zhang, Cunlin; Zhao, Yuejin

2018-01-01

Terahertz (THz) wave has attracted considerable attention in recent years because of its potential applications. The intense THz waves generated from air plasma induced by two-color femtosecond laser are widely used due to its high generation efficiency and broad frequency bandwidth. The parameters of the laser change the distribution of the air plasma, and then affect the generation of THz wave. In this research, we investigate the THz wave generation from air plasma induced by quasi-square Airy beam. Unlike the common Gauss beam, the quasi-square Airy beam has ability to autofocus and to increase the maximum intensity at the focus. By using the spatial light modulator (SLM), we can change the parameters of phase map to control the shape of the Airy beam. We obtain the two-color laser field by a 100-um-thick BBO crystal, then use a Golay detector to record THz wave energy. By comparing terahertz generation at different modulation depths, we find that terahertz energy produced by quasi-square Airy beam is up to 3.1 times stronger than that of Gauss beam with identical laser energy. In order to understand the influence of quasi-square Airy beam on the BBO crystal, we record THz wave energy by changing the azimuthal angle of BBO crystal with Gauss beam and Airy beam at different modulation depths. We find that the trend of terahertz energy with respect to the azimuthal angle of the BBO crystal keeps the same for different laser beams. We believe that the quasi-square Airy beam or other auto focusing beam can significantly improve the efficiency of terahertz wave generation and pave the way for its applications.

Generation of disc-like plasma from laser-matter interaction in the presence of a strong external magnetic field

DOE PAGES

Ivanov, V. V.; Maximov, A. V.; Betti, R.; ...

2017-05-16

Dynamics of laser produced plasma in a strong magnetic field was studied here using a 1 MA pulsed power generator coupled to an intense, high-energy laser. A 2–2.5 MG magnetic field was generated on the surface of a rod load 0.8–1.2 mm in diameter. A sub-nanosecond laser pulse with intensity of 3 × 10 15 W cm -2 was focused on the rod load surface. Side-on laser diagnostics showed the generation of two collimated jets 1–3 mm long on the front and rear sides of the load. End-on laser diagnostics reveal that the laser produced plasma in the MG magneticmore » field takes the form of a thin disc as the plasma propagates along the magnetic field lines. The disc-like plasma expands radially across the magnetic field with a velocity of 250 km s -1. An electron temperature of 400 eV was measured in the laser-produced plasma on the rod load.« less

Generation of disc-like plasma from laser-matter interaction in the presence of a strong external magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ivanov, V. V.; Maximov, A. V.; Betti, R.

Dynamics of laser produced plasma in a strong magnetic field was studied here using a 1 MA pulsed power generator coupled to an intense, high-energy laser. A 2–2.5 MG magnetic field was generated on the surface of a rod load 0.8–1.2 mm in diameter. A sub-nanosecond laser pulse with intensity of 3 × 10 15 W cm -2 was focused on the rod load surface. Side-on laser diagnostics showed the generation of two collimated jets 1–3 mm long on the front and rear sides of the load. End-on laser diagnostics reveal that the laser produced plasma in the MG magneticmore » field takes the form of a thin disc as the plasma propagates along the magnetic field lines. The disc-like plasma expands radially across the magnetic field with a velocity of 250 km s -1. An electron temperature of 400 eV was measured in the laser-produced plasma on the rod load.« less

Electron emission and plasma generation in a modulator electron gun using ferroelectric cathode

NASA Astrophysics Data System (ADS)

Chen, Shutao; Zheng, Shuxin; Zhu, Ziqiu; Dong, Xianlin; Tang, Chuanxiang

2006-10-01

Strong electron emission and dense plasma generation have been observed in a modulator electron gun with a Ba 0.67Sr 0.33TiO 3 ferroelectric cathode. Parameter of the modulator electron gun and lifetime of the ferroelectric cathode were investigated. It was shown that electron emission from Ba 0.67Sr 0.33TiO 3 cathode with a positive triggering pulse is a sort of plasma emission. Electrons were emitted by the co-effect of surface plasma and non-compensated negative polarization charges at the surface of the ferroelectric. The element analyses of the graphite collector after emission process was performed to show the ingredient of the plasma consist of Ba, Ti and Cu heavy cations of the ceramic compound and electrode. It was demonstrated the validity of the Child-Langmuir law by introducing the decrease of vacuum gap and increase of emission area caused by the expansion of the surface plasma.

Characteristics of the NASA Lewis bumpy-torus plasma generated with positive applied potentials

NASA Technical Reports Server (NTRS)

Roth, J. R.; Gerdin, G. A.; Richardson, R. W.

1976-01-01

Experimental observations were made during steady-state operation of a bumpy-torus plasma at input powers up to 150 kW in deuterium and helium gas and with positive potentials applied to the midplane electrodes. In this steady-state ion heating method a modified Penning discharge is operated such that the plasma is acted upon by a combination of strong electric and magnetic fields. Experimental investigation of a deuterium plasma revealed electron temperatures from 14 to 140 eV and ion kinetic temperatures from 160 to 1785 eV. At least two distinct modes of operation exist. Experimental data shows that the average ion residence time in the plasma is virtually independent of the magnetic field strength. Data was taken when all 12 anode rings were at high voltage, and in other symmetric configurations in which the toroidal plasma was generated by applying positive potentials to six anode rings, three anode rings, and a single anode ring.

Five isomers of C 60 generated in microwave plasma of chloroform

NASA Astrophysics Data System (ADS)

Xie, Su-Yuan; Deng, Shun-Liu; Huang, Rong-Bin; Yu, La-Jia; Zheng, Lan-Sun

2001-08-01

In addition to Ih symmetry buckminsterfullerene, four other isomers of C 60 were generated in a microwave plasma of chloroform. The newly observed isomers, separated and identified by a high performance liquid chromatography coupled with mass spectrometry (HPLC-MS), were found to be stable at room temperature but transform to buckminsterfullerene when heated. With regards to the generation of various fully chlorinated carbon clusters as well as the C 60 isomers, which may be attributed to the rapidly cooling of the synthetic reaction, a modified Pentagon Road scheme is suggested for fullerene formation.

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation

PubMed Central

Hess, Katharina; Ajjan, Ramzi; Phoenix, Fladia; Dobó, József; Gál, Péter; Schroeder, Verena

2012-01-01

Background Numerous interactions between the coagulation and complement systems have been shown. Recently, links between coagulation and mannan-binding lectin-associated serine protease-1 (MASP-1) of the complement lectin pathway have been proposed. Our aim was to investigate MASP-1 activation of factor XIII (FXIII), fibrinogen, prothrombin, and thrombin-activatable fibrinolysis inhibitor (TAFI) in plasma-based systems, and to analyse effects of MASP-1 on plasma clot formation, structure and lysis. Methodology/Principal Findings We used a FXIII incorporation assay and specific assays to measure the activation products prothrombin fragment F1+2, fibrinopeptide A (FPA), and activated TAFI (TAFIa). Clot formation and lysis were assessed by turbidimetric assay. Clot structure was studied by scanning electron microscopy. MASP-1 activated FXIII and, contrary to thrombin, induced FXIII activity faster in the Val34 than the Leu34 variant. MASP-1-dependent generation of F1+2, FPA and TAFIa showed a dose-dependent response in normal citrated plasma (NCP), albeit MASP-1 was much less efficient than FXa or thrombin. MASP-1 activation of prothrombin and TAFI cleavage were confirmed in purified systems. No FPA generation was observed in prothrombin-depleted plasma. MASP-1 induced clot formation in NCP, affected clot structure, and prolonged clot lysis. Conclusions/Significance We show that MASP-1 interacts with plasma clot formation on different levels and influences fibrin structure. Although MASP-1-induced fibrin formation is thrombin-dependent, MASP-1 directly activates prothrombin, FXIII and TAFI. We suggest that MASP-1, in concerted action with other complement and coagulation proteins, may play a role in fibrin clot formation. PMID:22536427

Low edge safety factor operation and passive disruption avoidance in current carrying plasmas by the addition of stellarator rotational transform

NASA Astrophysics Data System (ADS)

Pandya, M. D.; ArchMiller, M. C.; Cianciosa, M. R.; Ennis, D. A.; Hanson, J. D.; Hartwell, G. J.; Hebert, J. D.; Herfindal, J. L.; Knowlton, S. F.; Ma, X.; Massidda, S.; Maurer, D. A.; Roberds, N. A.; Traverso, P. J.

2015-11-01

Low edge safety factor operation at a value less than two ( q (a )=1 /ι̷tot(a )<2 ) is routine on the Compact Toroidal Hybrid device with the addition of sufficient external rotational transform. Presently, the operational space of this current carrying stellarator extends down to q (a )=1.2 without significant n = 1 kink mode activity after the initial plasma current rise phase of the discharge. The disruption dynamics of these low edge safety factor plasmas depend upon the fraction of helical field rotational transform from external stellarator coils to that generated by the plasma current. We observe that with approximately 10% of the total rotational transform supplied by the stellarator coils, low edge q disruptions are passively suppressed and avoided even though q(a) < 2. When the plasma does disrupt, the instability precursors measured and implicated as the cause are internal tearing modes with poloidal, m, and toroidal, n, helical mode numbers of m /n =3 /2 and 4/3 observed on external magnetic sensors and m /n =1 /1 activity observed on core soft x-ray emissivity measurements. Even though the edge safety factor passes through and becomes much less than q(a) < 2, external n = 1 kink mode activity does not appear to play a significant role in the disruption phenomenology observed.

Increasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatin.

PubMed

Gottsäter, A; Anwaar, I; Lind, P; Mattiasson, I; Lindgärde, F

1999-04-01

Lipid-lowering statin treatment reduces cardiovascular morbidity and mortality and improves endothelial function in patients with hypercholesterolemia. The aim of the present study was to evaluate plasma levels of fibrinogen, factor VII, and the macrophage-derived inflammatory mediator neopterin during lipid lowering. In addition, the endothelial production of platelet antiaggregatory and vasodilatory factors such as nitric oxide and prostacyclin, and vasoconstrictive factors such as endothelin-1, was assessed. Plasma fibrinogen, factor VII, endothelin-1, and the neopterin and intraplatelet nitric oxide and prostacyclin mediators cyclic 3'-5'guanosine monophosphate (cGMP) and cyclic 3'-5'adenosine monophosphate (cAMP) were measured before and 6 months after the institution of treatment with fluvastatin in 17 patients (eight men and nine women, median age 60 years) with vascular disease and previously untreated hypercholesterolemia. After 6 months, a decrease of 1.62 mmol/l [1.26-2.18 (19%); P < 0.01] was noted in levels of total cholesterol, and a decrease of 1.70 mmol/l [1.52-2.30 (28%); P < 0.01] in levels of low-density lipoprotein cholesterol. Plasma levels of fibrinogen had increased [from 4.81 g/l (4.26-5.27) to 5.17 g/l (4.81-5.67); P < 0.05], whereas no significant changes had occurred in intraplatelet levels of cGMP [decrease by 0.05 pmol/10(9) platelets (-0.17 to 0.24); NS], cAMP [decrease by 0.13 pmol/10(9) platelets (-0.37 to 0.86); NS], plasma endothelin-1 [decrease by 0.05 pg/ml (-0.60 to 0.70); NS], plasma factor VII [from 1.14 IE/ml (0.58-1.38) to 1.22 IE/ml (0.96-1.46); NS], or plasma neopterin [from 8.6 nmol/l (7.1-11.5) to 8.7 nmol/l (7.9-11.3); NS]. In conclusion, during cholesterol-lowering treatment with fluvastatin, plasma levels of fibrinogen increased whereas intraplatelet cyclic nucleotide levels and plasma endothelin-1, factor VII and neopterin levels were unchanged.

Specular reflectivity and hot-electron generation in high-contrast relativistic laser-plasma interactions

NASA Astrophysics Data System (ADS)

Kemp, Gregory Elijah

Ultra-intense laser (> 1018 W/cm2) interactions with matter are capable of producing relativistic electrons which have a variety of applications in state-of-the-art scientific and medical research conducted at universities and national laboratories across the world. Control of various aspects of these hot-electron distributions is highly desired to optimize a particular outcome. Hot-electron generation in low-contrast interactions, where significant amounts of under-dense pre-plasma are present, can be plagued by highly non-linear relativistic laser-plasma instabilities and quasi-static magnetic field generation, often resulting in less than desirable and predictable electron source characteristics. High-contrast interactions offer more controlled interactions but often at the cost of overall lower coupling and increased sensitivity to initial target conditions. An experiment studying the differences in hot-electron generation between high and low-contrast pulse interactions with solid density targets was performed on the Titan laser platform at the Jupiter Laser Facility at Lawrence Livermore National Laboratory in Livermore, CA. To date, these hot-electrons generated in the laboratory are not directly observable at the source of the interaction. Instead, indirect studies are performed using state-of-the-art simulations, constrained by the various experimental measurements. These measurements, more-often-than-not, rely on secondary processes generated by the transport of these electrons through the solid density materials which can susceptible to a variety instabilities and target material/geometry effects. Although often neglected in these types of studies, the specularly reflected light can provide invaluable insight as it is directly influenced by the interaction. In this thesis, I address the use of (personally obtained) experimental specular reflectivity measurements to indirectly study hot-electron generation in the context of high-contrast, relativistic

Tissue factor activity in women with preeclampsia or SGA: a potential explanation for the excessive thrombin generation in these syndromes.

PubMed

Erez, Offer; Romero, Roberto; Vaisbuch, Edi; Than, Nandor Gabor; Kusanovic, Juan Pedro; Mazaki-Tovi, Shali; Gotsch, Francesca; Mittal, Pooja; Dong, Zhong; Chaiworapongsa, Tinnakorn; Kim, Chong Jai; Nhan-Chang, Chia-Ling; Kim, Sun Kwon; Yeo, Lami; Mazor, Moshe; Hassan, Sonia S

2018-06-01

The aim of this study was to determine whether the activity of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the plasma of women with preeclampsia (PE) and small for gestational age (SGA) neonate differ from that of normal pregnant women and whether they are related to specific placental lesions. This cross-sectional study included the following groups: (1) normal pregnancy (n = 68); (2) PE (n= 128); and (3) SGA (n = 56). Maternal plasma TF and TFPI activity was determined with chromogenic assays. (1) The median maternal plasma TF activity, but not TFPI activity, differed among the study groups (p < .0001 and p = .4, respectively); (2) patients with PE had a higher median maternal plasma TF activity than women with normal pregnancies (p < .0001) and mothers with SGA fetuses (p = .002); (3) among patients with PE, those with distal villous hypoplasia had a higher median maternal TF activity than those without these placental lesions (p = .018); and (4) following adjustment for confounding variables, maternal plasma TF and TFPI activity were not associated with an SGA neonate. Plasma TF activity is higher in women with PE than in those with SGA or normal pregnancies. We propose that these changes may be responsible, at least in part, for the increased in-vivo thrombin generation observed in this obstetrical syndrome.

Simulations of a dense plasma focus on a high impedance generator

NASA Astrophysics Data System (ADS)

Beresnyak, Andrey; Giuliani, John; Jackson, Stuart; Richardson, Steve; Swanekamp, Steve; Schumer, Joe; Commisso, Robert; Mosher, Dave; Weber, Bruce; Velikovich, Alexander

2017-10-01

We study the connection between plasma instabilities and fast ion acceleration for neutron production on a Dense Plasma Focus (DPF). The experiments will be performed on the HAWK generator (665 kA), which has fast rise time, 1.2 μs, and a high inductance, 607 nH. It is hypothesized that high impedance may enhance the neutron yield because the current will not be reduced during the collapse resulting in higher magnetization. To prevent upstream breakdown, we will inject plasma far from the insulator stack. We simulated rundown and collapse dynamics with Athena - Eulerian 3D, unsplit finite volume MHD code that includes shock capturing with Riemann solvers, resistive diffusion and the Hall term. The simulations are coupled to an equivalent circuit model for HAWK. We will report the dynamics and implosion time as a function of the initial injected plasma distribution and the implications of non-ideal effects. We also traced test particles in MHD fields and confirmed the presence of stochastic acceleration, which was limited by the size of the system and the strength of the magnetic field. Supported by DOE/NNSA and the Naval Research Laboratory Base Program.

Plasma Streamwise Vortex Generators in an Adverse Pressure Gradient

NASA Astrophysics Data System (ADS)

Kelley, Christopher; Corke, Thomas; Thomas, Flint

2013-11-01

A wind tunnel experiment was conducted to compare plasma streamwise vortex generators (PSVGs) and passive vortex generators (VGs). These devices were installed on a wing section by which the angle of attack could be used to vary the streamwise pressure gradient. The experiment was performed for freestream Mach numbers 0.1-0.2. Three-dimensional velocity components were measured using a 5-hole Pitot probe in the boundary layer. These measurements were used to quantify the production of streamwise vorticity and the magnitude of the reorientation term from the vorticity transport equation. The effect of Mach number, pressure gradient, operating voltage, and electrode length was then investigated for the PSVGs. The results indicate that the PSVGs could easily outperform the passive VGs and provide a suitable alternative for flow control.

Research progress on ionic plasmas generated in an intense hydrogen negative ion source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takeiri, Y., E-mail: takeiri@nifs.ac.jp; Tsumori, K.; Nagaoka, K.

2015-04-08

Characteristics of ionic plasmas, observed in a high-density hydrogen negative ion source, are investigated with a multi-diagnostics system. The ionic plasma, which consists of hydrogen positive- and negative-ions with a significantly low-density of electrons, is generated in the ion extraction region, from which the negative ions are extracted through the plasma grid. The negative ion density, i.e., the ionic plasma density, as high as the order of 1×10{sup 17}m{sup −3}, is measured with cavity ring-down spectroscopy, while the electron density is lower than 1×10{sup 16}m{sup −3}, which is confirmed with millimeter-wave interferometer. Reduction of the negative ion density is observedmore » at the negative ion extraction, and at that time the electron flow into the ionic plasma region is observed to conserve the charge neutrality. Distribution of the plasma potential is measured in the extraction region in the direction normal to the plasma grid surface with a Langmuir probe, and the results suggest that the sheath is formed at the plasma boundary to the plasma grid to which the bias voltage is applied. The beam extraction should drive the negative ion transport in the ionic plasma across the sheath formed on the extraction surface. Larger reduction of the negative ions at the beam extraction is observed in a region above the extraction aperture on the plasma grid, which is confirmed with 2D image measurement of the Hα emission and cavity ring-down spectroscopy. The electron distribution is also measured near the plasma grid surface. These various properties observed in the ionic plasma are discussed.« less

Ionization-potential depression and dynamical structure factor in dense plasmas

NASA Astrophysics Data System (ADS)

Lin, Chengliang; Röpke, Gerd; Kraeft, Wolf-Dietrich; Reinholz, Heidi

2017-07-01

The properties of a bound electron system immersed in a plasma environment are strongly modified by the surrounding plasma. The modification of an essential quantity, the ionization energy, is described by the electronic and ionic self-energies, including dynamical screening within the framework of the quantum statistical theory. Introducing the ionic dynamical structure factor as the indicator for the ionic microfield, we demonstrate that ionic correlations and fluctuations play a critical role in determining the ionization potential depression. This is, in particular, true for mixtures of different ions with large mass and charge asymmetry. The ionization potential depression is calculated for dense aluminum plasmas as well as for a CH plasma and compared to the experimental data and more phenomenological approaches used so far.

Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients.

PubMed

van Geffen, Mark; Mathijssen, Natascha C J; Holme, Pål A; Laros-van Gorkom, Britta A P; van Kraaij, Marian G J; Masereeuw, Roselinde; Peyvandi, Flora; van Heerde, Waander L

2013-07-01

Recombinant activated factor VII (rFVIIa) and plasma-derived factor VII (pdFVII) are used to prevent bleedings in severe FVII deficient patients, despite their short half-lifes. It is suggested that FVII levels of 15-20 IU/dL are sufficient to maintain hemostasis. We analyzed the pharmacodynamic effects of FVII substitution therapy in the Nijmegen Hemostasis Assay (NHA) that simultaneously measures thrombin and plasmin generation. Ten severe FVII deficient patients were treated with 20 μg/kg rFVIIa or 25 IU/kg pdFVII in a cross-over design. Thrombin generation lag-time (TG-LT) was identified as an effect-response parameter. Pharmacodynamic analysis using a maximum effect model showed 50% reduction of the TG-LT effect at ~2 IU/dL FVII activity for both rFVIIa and pdFVII. The FVII activity to obtain TG-LT comparable to the upper limit of normal range in healthy controls (4 min) was given by the effective concentration (ECnormal), showing sufficient hemostasis at 3-4 IU/dL FVII activity. No association was seen between FVII activity and other thrombin or plasmin generation parameters as measured by NHA. In conclusion, 3-4 IU/dL FVII activity seems sufficient to maintain hemostasis in patients with severe FVII deficiency during prophylaxis. These data may suggest a potential value for measurement of TG-LT in the monitoring of FVII(a) therapy. Copyright © 2013 Elsevier Ltd. All rights reserved.

Gyrofluid Simulations of Intrinsic Rotation Generation in Reversed Shear Plasmas with Internal Transport Barriers

NASA Astrophysics Data System (ADS)

Jhang, Hogun; Kim, S. S.; Kwon, J. M.; Terzolo, L.; Kim, J. Y.; Diamond, P. H.

2010-11-01

It is accepted that the intrinsic rotation is generated via the residual stress, which is non-diffusive components of the turbulent Reynolds stress, without external momentum input. The physics leading to the onset of intrinsic rotation in L- and H- mode plasmas have been elucidated elsewhere. However, the physics responsible for the generation and transport of the intrinsic rotation and its relationship to the formation of internal transport barriers (ITBs) in reversed shear (RS) plasmas have not been explored in detail, which is the main subject in the present work. The revised version of the global gyrofluid code TRB is used for this study. It is found that the large intrinsic rotation (˜10-30% of the ion sound speed depending on ITB characteristics) is generated near the ITB region and propagates into the core. The intrinsic rotation increases linearly as the temperature gradient at ITB position increases, albeit not indefinitely. Key parameters related to the symmetry breaking, such as turbulent intensity and its gradient, the flux surface averaged parallel wavenumber are evaluated dynamically during the ITB formation. In particular, the role of reversed shear and the q-profile curvature is presented in relation to the symmetry breaking in RS plasmas.

Plasma levels of hypoxia-regulated factors in patients with age-related macular degeneration.

PubMed

Ioanna, Zygoula; Christian, Schori; Christian, Grimm; Daniel, Barthelmes

2018-02-01

Various hypoxia-related proteins are differentially expressed in the retina and secreted to the vitreous and/or aqueous humor of patients affected by dry or neovascular age-related macular degeneration (nAMD). To determine whether these conditions alter concentrations of cytokines also in the systemic circulation, we measured plasma levels of six hypoxia-related proteins. Plasma was prepared from EDTA blood that was collected from patients affected by dry AMD (n = 5), nAMD (n = 11), proliferative diabetic retinopathy (PDR; n = 9), and patients with an epiretinal membrane (ERM; n = 11). ERM samples served as negative controls, PDR samples as positive controls. Protein concentrations of vascular endothelial growth factor (VEGF), erythropoietin (EPO), angiopoietin-like 4 (ANGPTL4), placental growth factor (PlGF), tumor necrosis factor alpha (TNF-α), and pigment epithelium-derived factor (PEDF) were determined by enzyme-linked immunosorbent assay (ELISA). The concentration of PlGF was significantly increased in plasma of patients affected by nAMD. Although no statistically significant differences were found for EPO, ANGPTL4, PlGF, TNF-α, and PEDF, the mean concentration of VEGF was lowest in the nAMD group. Plasma concentrations of the six factors did not correlate with gender or age of patients. nAMD may increase plasma concentrations of PlGF, making it a candidate as a biomarker for the neovascular form of AMD. Other factors, however, were not differentially regulated, suggesting that their systemic concentrations are not generally increased in hypoxia-related retinal diseases.

Plasma brain-derived neurotrophic factor in women after bariatric surgery: a pilot study.

PubMed

Merhi, Zaher O; Minkoff, Howard; Lambert-Messerlian, Geralyn M; Macura, Jerzy; Feldman, Joseph; Seifer, David B

2009-04-01

Eighteen morbidly obese women had plasma brain-derived neurotrophic factor (BDNF) measured before bariatric surgery and 3 months postoperatively. We analyzed plasma BDNF levels in all the participants then subdivided according to menopausal status and type of surgery. Brain-derived neurotrophic factor decreased significantly in all the participants and in the premenopausal group when looked at in isolation.

Brilliant petawatt gamma-ray pulse generation in quantum electrodynamic laser-plasma interaction

PubMed Central

Chang, H. X.; Qiao, B.; Huang, T. W.; Xu, Z.; Zhou, C. T.; Gu, Y. Q.; Yan, X. Q.; Zepf, M.; He, X. T.

2017-01-01

We show a new resonance acceleration scheme for generating ultradense relativistic electron bunches in helical motions and hence emitting brilliant vortical γ-ray pulses in the quantum electrodynamic (QED) regime of circularly-polarized (CP) laser-plasma interactions. Here the combined effects of the radiation reaction recoil force and the self-generated magnetic fields result in not only trapping of a great amount of electrons in laser-produced plasma channel, but also significant broadening of the resonance bandwidth between laser frequency and that of electron betatron oscillation in the channel, which eventually leads to formation of the ultradense electron bunch under resonant helical motion in CP laser fields. Three-dimensional PIC simulations show that a brilliant γ-ray pulse with unprecedented power of 6.7 PW and peak brightness of 1025 photons/s/mm2/mrad2/0.1% BW (at 15 MeV) is emitted at laser intensity of 1.9 × 1023 W/cm2. PMID:28338010

Fibulin-1 purification from human plasma using affinity chromatography on Factor H-Sepharose

PubMed Central

DiScipio, Richard G.; Liddington, Robert C.; Schraufstatter, Ingrid U.

2016-01-01

A method is reported to purify Fibulin-1 from human plasma resulting in a 36% recovery. The steps involve removal of the cryoglobulin and the vitamin K dependent proteins followed by polyethylene glycol and ammonium sulfate precipitations, DEAE-Sephadex column chromatography and finally Factor H-Sepharose affinity purification. The procedure is designed to be integrated into an overall scheme for the isolation of over 30 plasma proteins from a single batch of human plasma. Results from mass spectroscopy, SDS-PAGE, and Western blotting indicate that human plasma Fibulin-1 is a single chain of the largest isotype. Functional binding assays demonstrated calcium ion dependent interaction of Fibulin-1 for fibrinogen, fibronectin, and Factor H. The procedure described is the first to our knowledge that enables a large scale purification of Fibulin-1 from human plasma. PMID:26826315

X-Ray generation in strongly nonlinear plasma waves.

NASA Astrophysics Data System (ADS)

Kiselev, Sergey; Pukhov, Alexander; Kostyukov, Igor

2004-11-01

Using three-dimensional particle-in-cell simulations we show that a strongly nonlinear plasma wave excited by an ultrahigh intensity laser pulse works as a compact high-brightness source of Xray radiation. It has been recently suggested by A. Pukhov and J. Meyer-ter-Vehn, Appl. Phys. B 74, 355 (2002), that in a strongly nonlinear regime the plasma wave transforms to a ``bubble'', which is almost free from background electrons. Inside the bubble, a dense bunch of relativistic electrons is produced. These accelerated electrons make betatron oscillations in the transverse fields of the bubble and emit a bright broadband X-ray radiation with a maximum about 50 keV. The emission is confined to a small angle of about 0.1 rad. In addition, we make simulations of X-ray generation by an external 28.5-GeV electron bunch injected into the bubble. Gamma-quanta with up to GeV energies are observed in the simulation in a good agreement with analytical results. The energy conversion is efficient, leading to a significant stopping of the electron bunch over 5 mm interaction distance.

Magnetic field generation in core-sheath jets via the kinetic Kelvin-Helmholtz instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nishikawa, K.-I.; Hardee, P. E.; Duţan, I.

2014-09-20

We have investigated magnetic field generation in velocity shears via the kinetic Kelvin-Helmholtz instability (kKHI) using a relativistic plasma jet core and stationary plasma sheath. Our three-dimensional particle-in-cell simulations consider plasma jet cores with Lorentz factors of 1.5, 5, and 15 for both electron-proton and electron-positron plasmas. For electron-proton plasmas, we find generation of strong large-scale DC currents and magnetic fields that extend over the entire shear surface and reach thicknesses of a few tens of electron skin depths. For electron-positron plasmas, we find generation of alternating currents and magnetic fields. Jet and sheath plasmas are accelerated across the shearmore » surface in the strong magnetic fields generated by the kKHI. The mixing of jet and sheath plasmas generates a transverse structure similar to that produced by the Weibel instability.« less

Evaluation of procoagulant tissue factor expression in canine hemangiosarcoma cell lines

PubMed Central

Witter, Lauren E.; Gruber, Erika J.; Lean, Fabian Z. X.; Stokol, Tracy

2017-01-01

OBJECTIVE To evaluate expression of procoagulant tissue factor (TF) by canine hemangiosarcoma cells in vitro. SAMPLES 4 canine hemangiosarcoma cell lines (SB-HSA [mouse-passaged cutaneous tumor], Emma [primary metastatic brain tumor], and Frog and Dal-1 [primary splenic tumors]) and 1 nonneoplastic canine endothelial cell line (CnAoEC). PROCEDURES TF mRNA and TF antigen expression were evaluated by quantitative real-time PCR assay and flow cytometry, respectively. Thrombin generation was measured in canine plasma and in coagulation factor–replete or specific coagulation factor–deficient human plasma by calibrated automated thrombography. Corn trypsin inhibitor and annexin V were used to examine contributions of contact activation and membrane-bound phosphatidylserine, respectively, to thrombin generation. RESULTS All cell lines expressed TF mRNA and antigen, with significantly greater expression of both products in SB-HSA and Emma cells than in CnAoEC. A greater percentage of SB-HSA cells expressed TF antigen, compared with other hemangiosarcoma cell lines. All hemangiosarcoma cell lines generated significantly more thrombin than did CnAoEC in canine or factor-replete human plasma. Thrombin generation induced by SB-HSA cells was significantly lower in factor VII-deficient plasma than in factor-replete plasma and was abolished in factor X–deficient plasma; residual thrombin generation in FVII-deficient plasma was abolished by incubation of cells with annexin V. Thrombin generation by SB-HSA cells was unaffected by the addition of corn trypsin inhibitor. CONCLUSIONS AND CLINICAL RELEVANCE Hemangiosarcoma cell lines expressed procoagulant TF in vitro. Further research is needed to determine whether TF can be used as a biomarker for hemostatic dysfunction in dogs with hemangiosarcoma. PMID:28029283

Surface plasma wave assisted second harmonic generation of laser over a metal film

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chauhan, Santosh; Parashar, J., E-mail: j.p.parashar@gmail.com

2015-01-15

Second harmonic generation of laser mode converted surface plasma wave (SPW) over a corrugated metal film is studied. The laser, impinged on the metal film, under attenuated total reflection configuration, excites SPW over the metal–vacuum interface. The excited SPW extends over a much wider surface area than the laser spot cross-section. It exerts a second harmonic ponderomotive force on metal electrons, imparting them velocity that beats with the surface ripple to produce a nonlinear current, driving resonant second harmonic surface plasma wave.

Sterilization of Fusarium oxysporum by treatment of non-thermalequilibrium plasma in nutrient solution

NASA Astrophysics Data System (ADS)

Yasui, Shinji; Seki, Satoshi; Yoshida, Ryohei; Shoji, Kazuhiro; Terazoe, Hitoshi

2016-01-01

Fusarium wilt of spinach due to F. oxysporum infection is one of the most destructive root diseases in hydroponics in factories using the nutrient film technique. We investigated new technologies for the sterilization of microconidia of F. oxysporum by using a non-thermalequilibrium plasma treatment method in nutrient solution. Specifically, we investigated the sterilization capabilities of five types of gas (air, O2, N2, He, and Ar) used for plasma generation. The highest sterilization capability was achieved by using O2 plasma. However, ozone, which causes growth inhibition, was then generated and released into the atmosphere. The sterilization capability was lower when N2 or air plasma was used in the nutrient solution. It was confirmed that sterilization can be achieved by plasma treatment using inert gases that do not generate ozone; therefore, we determined that Ar plasma is the most preferable. In addition, we investigated the sterilization capabilities of other factors associated with Ar plasma generation, without direct plasma treatment. However, none of these other factors, which included Ar bubbling, pH reduction, increased temperature, hydrogen peroxide concentration, and UV radiation, could completely reproduce the results of direct plasma treatment. We assume that radicals such as O or OH may contribute significantly to the sterilization of microconidia of F. oxysporum in a nutrient solution.

Characterization of a deuterium-deuterium plasma fusion neutron generator

NASA Astrophysics Data System (ADS)

Lang, R. F.; Pienaar, J.; Hogenbirk, E.; Masson, D.; Nolte, R.; Zimbal, A.; Röttger, S.; Benabderrahmane, M. L.; Bruno, G.

2018-01-01

We characterize the neutron output of a deuterium-deuterium plasma fusion neutron generator, model 35-DD-W-S, manufactured by NSD/Gradel-Fusion. The measured energy spectrum is found to be dominated by neutron peaks at 2.2 MeV and 2.7 MeV. A detailed GEANT4 simulation accurately reproduces the measured energy spectrum and confirms our understanding of the fusion process in this generator. Additionally, a contribution of 14 . 1 MeV neutrons from deuterium-tritium fusion is found at a level of 3 . 5%, from tritium produced in previous deuterium-deuterium reactions. We have measured both the absolute neutron flux as well as its relative variation on the operational parameters of the generator. We find the flux to be proportional to voltage V 3 . 32 ± 0 . 14 and current I 0 . 97 ± 0 . 01. Further, we have measured the angular dependence of the neutron emission with respect to the polar angle. We conclude that it is well described by isotropic production of neutrons within the cathode field cage.

Advanced Thomson scattering system for high-flux linear plasma generator.

PubMed

van der Meiden, H J; Lof, A R; van den Berg, M A; Brons, S; Donné, A J H; van Eck, H J N; Koelman, P M J; Koppers, W R; Kruijt, O G; Naumenko, N N; Oyevaar, T; Prins, P R; Rapp, J; Scholten, J; Schram, D C; Smeets, P H M; van der Star, G; Tugarinov, S N; Zeijlmans van Emmichoven, P A

2012-12-01

An advanced Thomson scattering system has been built for a linear plasma generator for plasma surface interaction studies. The Thomson scattering system is based on a Nd:YAG laser operating at the second harmonic and a detection branch featuring a high etendue (f/3) transmission grating spectrometer equipped with an intensified charged coupled device camera. The system is able to measure electron density (n(e)) and temperature (T(e)) profiles close to the output of the plasma source and, at a distance of 1.25 m, just in front of a target. The detection system enables to measure 50 spatial channels of about 2 mm each, along a laser chord of 95 mm. By summing a total of 30 laser pulses (0.6 J, 10 Hz), an observational error of 3% in n(e) and 6% in T(e) (at n(e) = 9.4 × 10(18) m(-3)) can be obtained. Single pulse Thomson scattering measurements can be performed with the same accuracy for n(e) > 2.8 × 10(20) m(-3). The minimum measurable density and temperature are n(e) < 1 × 10(17) m(-3) and T(e) < 0.07 eV, respectively. In addition, using the Rayleigh peak, superimposed on the Thomson scattered spectrum, the neutral density (n(0)) of the plasma can be measured with an accuracy of 25% (at n(0) = 1 × 10(20) m(-3)). In this report, the performance of the Thomson scattering system will be shown along with unprecedented accurate Thomson-Rayleigh scattering measurements on a low-temperature argon plasma expansion into a low-pressure background.

Generation of anomalously energetic suprathermal electrons by an electron beam interacting with a nonuniform plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sydorenko, D.; Kaganovich, I. D.; Chen, L.

Generation of anomalously energetic suprathermal electrons was observed in simulation of a high-voltage dc discharge with electron emission from the cathode. An electron beam produced by the emission interacts with the nonuniform plasma in the discharge via a two-stream instability. The energy transfer from the beam to the plasma electrons is ensured by the plasma nonuniformity. The electron beam excites plasma waves whose wavelength and phase speed gradually decrease towards anode. The waves with short wavelength near the anode accelerate plasma bulk electrons to suprathermal energies. The sheath near the anode reflects some of the accelerated electrons back into themore » plasma. These electrons travel through the plasma, reflect near the cathode, and enter the accelerating area again but with a higher energy than before. Such particles are accelerated to energies much higher than after the first acceleration. This mechanism plays a role in explaining earlier experimental observations of energetic suprathermal electrons in similar discharges.« less

Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors

PubMed Central

Ogston, Derek; Ogston, C. Marie; Ratnoff, Oscar D.; Forbes, Charles D.

1969-01-01

As demonstrated by others, fibrinolytic activity was generated in diluted, acidified normal plasma exposed to kaolin, a process requiring Hageman factor (Factor XII). Generation was impaired by adsorbing plasma with glass or similar agents under conditions which did not deplete its content of Hageman factor or plasminogen. The defect could be repaired by addition of a noneuglobulin fraction of plasma or an agent or agents eluted from diatomaceous earth which had been exposed to normal plasma. The restorative agent, tentatively called Hageman factor-cofactor, was partially purified by chromatography and had an apparent molecular weight of approximately 165,000. It could be distinguished from plasma thromboplastin antecedent (Factor XI) and plasma kallikrein, other substrates of Hageman factor, and from the streptokinase-activated pro-activator of plasminogen. Evidence is presented that an additional component may be needed for the generation of fibrinolytic activity in mixtures containing Hageman factor, HF-cofactor, and plasminogen. The long-recognized generation of plasmin activity in chloroform-treated euglobulin fractions of plasma was found to be dependent upon the presence of Hageman factor. Whether chloroform activation of plasminogen requires Hageman factor-cofactor was not determined, but glass-adsorbed plasma, containing Hageman factor and plasminogen, did not generate appreciable fibrinolytic or caseinolytic activity. These studies emphasize the complex nature of the mechanisms which lead to the generation of plasmin in human plasma. PMID:4241814

Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor

NASA Astrophysics Data System (ADS)

Tormoen, Garth W.; Khader, Ayesha; Gruber, András; McCarty, Owen J. T.

2013-06-01

Thrombosis significantly contributes to cancer morbidity and mortality. The mechanism behind thrombosis in cancer may be circulating tissue factor (TF), as levels of circulating TF are associated with thrombosis. However, circulating TF antigen level alone has failed to predict thrombosis in patients with cancer. We hypothesize that coagulation factor levels regulate the kinetics of circulating TF-induced thrombosis. Coagulation kinetics were measured as a function of individual coagulation factor levels and TF particle concentration. Clotting times increased when pooled plasma was mixed at or above a ratio of 4:6 with PBS. Clotting times increased when pooled plasma was mixed at or above a ratio of 8:2 with factor VII-depleted plasma, 7:3 with factor IX- or factor X-depleted plasmas, or 2:8 with factor II-, V- or VIII-depleted plasmas. Addition of coagulation factors VII, X, IX, V and II to depleted plasmas shortened clotting and enzyme initiation times, and increased enzyme generation rates in a concentration-dependent manner. Only additions of factors IX and X from low-normal to high-normal levels shortened clotting times and increased enzyme generation rates. Our results demonstrate that coagulation kinetics for TF particles are controlled by factor IX and X levels within the normal physiological range. We hypothesize that individual patient factor IX and X levels may be prognostic for susceptibility to circulating TF-induced thrombosis.

Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

PubMed

Ohlmann, Philippe; Hechler, Béatrice; Chafey, Philippe; Ravanat, Catherine; Isola, Hervé; Wiesel, Marie-Louise; Cazenave, Jean-Pierre; Gachet, Christian

2016-09-01

The INTERCEPT Blood System (IBS) using amotosalen-HCl and ultraviolet (UV)A inactivates a large spectrum of microbial pathogens and white blood cells in therapeutic plasma. Our aim was to evaluate to what extent IBS modifies the capacity of plasma to generate thrombin and induces qualitative or quantitative modifications of plasma proteins. Plasma units from four donors were collected by apheresis. Samples were taken before (control [CTRL]) and after IBS treatment and stored at -80°C until use. The activities of plasma coagulation factors and inhibitors and the thrombin generation potential were determined using assays measuring clotting times and the calibrated automated thrombogram (CAT), respectively. The proteomic profile of plasma proteins was examined using a two-dimensional differential in-gel electrophoresis (2D-DIGE) method. Nearly all of the procoagulant and antithrombotic factors tested retained at least 78% of their initial pre-IBS activity. Only FVII and FVIII displayed a lower level of conservation (67%), which nevertheless remained within the reference range for conventional plasma coagulation factors. The thrombin generation profile of plasma was conserved after IBS treatment. Among the 1331 protein spots revealed by 2D-DIGE analysis, only four were differentially expressed in IBS plasma compared to CTRL plasma and two were identified by mass spectrometric analysis as transthyretin and apolipoprotein A1. The IBS technique for plasma moderately decreases the activities of plasma coagulation factors and antithrombotic proteins, with no impact on the thrombin generation potential of plasma and very limited modifications of the proteomic profile. © 2016 AABB.

Effect of Time Dependent Bending of Current Sheets in Response to Generation of Plasma Jets and Reverse Currents

NASA Astrophysics Data System (ADS)

Frank, Anna

Magnetic reconnection is a basis for many impulsive phenomena in space and laboratory plasmas accompanied by effective transformation of magnetic energy. Reconnection processes usually occur in relatively thin current sheets (CSs), which separate magnetic fields of different or opposite directions. We report on recent observations of time dependent bending of CSs, which results from plasma dynamics inside the sheet. The experiments are carried out with the CS-3D laboratory device (Institute of General Physics RAS, Moscow) [1]. The CS magnetic structure with an X line provides excitation of the Hall currents and plasma acceleration from the X line to both side edges [2]. In the presence of the guide field By the Hall currents give rise to bending of the sheet: the peripheral regions located away from the X line are deflected from CS middle plane (z=0) in the opposite directions ±z [3]. We have revealed generation of reverse currents jy near the CS edges, i.e. the currents flowing in the opposite direction to the main current in the sheet [4]. There are strong grounds to believe that reverse currents are generated by the outflow plasma jets [5], accelerated inside the sheet and penetrated into the regions with strong normal magnetic field component Bz [4]. An impressive effect of sudden change in the sign of the CS bend has been disclosed recently, when analyzing distributions of plasma density [6] and current away from the X line, in the presence of the guide field By. The CS configuration suddenly becomes opposite from that observed at the initial stage, and this effect correlates well with generation of reverse currents. Consequently this effect can be related to excitation of the reverse Hall currents owing to generation of reverse currents jy in the CS. Hence it may be concluded that CSs may exhibit time dependent vertical z-displacements, and the sheet geometry depends on excitation of the Hall currents, acceleration of plasma jets and generation of reverse

Drive Beam Shaping and Witness Bunch Generation for the Plasma Wakefield Accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

England, R. J.; Frederico, J.; Hogan, M. J.

2010-11-04

High transformer ratio operation of the plasma wake field accelerator requires a tailored drive beam current profile followed by a short witness bunch. We discuss techniques for generating the requisite dual bunches and for obtaining the desired drive beam profile, with emphasis on the FACET experiment at SLAC National Accelerator Laboratory.

Thrombin generation potential and clot-forming capacity of thawed fresh-frozen plasma, plasma frozen within 24 h and solvent/detergent-treated plasma (octaplasLG® ), during 5-day storage at 1-6°C.

PubMed

Heger, A; Neisser-Svae, A; Trawnicek, L; Triulzi, D

2018-04-23

To enable rapid availability of plasma in emergency situations, the shelf-life of thawed fresh-frozen plasma (FFP) has been extended from 24 h to 5 days. The aim of this study was to evaluate the thrombin generation (TG) potential and clot-forming ability during 5 days of refrigerated storage of thawed FFP, plasma frozen within 24 h and solvent/detergent-treated plasma octaplasLG ® . During storage for 5 days, TG capacity decreased significantly over time, and rotational thromboelastometry showed significantly prolonged clotting times. However, the stability studies confirmed comparable in vitro haemostatic potentials of all three thawed plasma products at day 5. © 2018 International Society of Blood Transfusion.

Generation of electric fields and currents by neutral flows in weakly ionized plasmas through collisional dynamos

NASA Astrophysics Data System (ADS)

Dimant, Y. S.; Oppenheim, M. M.; Fletcher, A. C.

2016-08-01

In weakly ionized plasmas neutral flows drag plasma across magnetic field lines generating intense electric fields and currents. An example occurs in the Earth's ionosphere near the geomagnetic equator. Similar processes take place in the Solar chromosphere and magnetohydrodynamic generators. This paper argues that not all convective neutral flows generate electric fields and currents and it introduces the corresponding universal criterion for their formation, ∇×(U ×B )≠∂B /∂t , where U is the neutral flow velocity, B is the magnetic field, and t is time. This criterion does not depend on the conductivity tensor, σ ̂ . For many systems, the displacement current, ∂B /∂t , is negligible making the criterion even simpler. This theory also shows that the neutral-dynamo driver that generates E-fields and currents plays the same role as the DC electric current plays for the generation of the magnetic field in the Biot-Savart law.

A linear-field plasma jet for generating a brush-shaped laminar plume at atmospheric pressure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Xuechen; Jia, Pengying, E-mail: plasmalab@126.com; Key Laboratory of Photo-Electronics Information Materials of Hebei Province, Baoding 071002

2016-06-15

A linear-field plasma jet composed of line-to-plate electrodes is used to generate a large-scale brush-shaped plasma plume with flowing argon used as working gas. Through electrical measurement and fast photography, it is found that the plasma plume bridges the two electrodes for the discharge in the positive voltage half-cycle, which behaves like fast moving plasma bullets directed from the anode to the cathode. Compared with the positive discharge, the negative discharge only develops inside the nozzle and propagates much slower. Results also indicate that the gas temperature of the plume is close to room temperature, which is promising for biomedicalmore » application.« less

Numerical Model of the Plasma Sheath Generated by the Plasma Source Instrument Aboard the Polar Satellite

NASA Technical Reports Server (NTRS)

Leung, Wing C.; Singh, Nagendra; Moore, Thomas E.; Craven, Paul D.

2000-01-01

The plasma sheath generated by the operation of the Plasma Source Instrument (PSI) aboard the POLAR satellite is studied by using a 3-dimensional Particle-In-Cell (PIC) code. When the satellite passes through the region of low density plasma, the satellite charges to positive potentials as high as 4050Volts due to the photoelectrons emission. In such a case, ambient core ions cannot accurately be measured or detected. The goal of the onboard PSI is to reduce the floating potential of the satellite to a sufficiently low value so that the ions in the polar wind become detectable. When the PSI is operated, an ion-rich Xenon plasma is ejected from the satellite, such that the floating potential of the satellite is reduced and is maintained at about 2Volts. Accordingly, in our 3-dimensional PIC simulation, we considered that the potential of the satellite is 2Volts as a fixed bias. Considering the relatively high density of the Xenon plasma in the sheath (approx. 10 - 10(exp 3)/cc), the ambient plasma of low density (less than 1/cc) is neglected. In the simulations, the electric fields and plasma dynamics are calculated self-consistently. We found that an "Apple" shape positive potential sheath forms surrounding the satellite. In the region near the PSI emission, a high positive potential hill develops. Near the Thermal Ion Detection Experiment (TIDE) detector away from the PSI, the potentials are sufficiently low for the ambient polar wind ions to reach it. In the simulations, it takes about a hundred electron gyroperiods for the sheath to reach a quasi-steady state. This time is approximately the time taken by the heavy Xe(+) ions to expand up to about one average Larmor radius of electrons from the satellite surface. Using the steady state sheath, we performed trajectory calculations to characterize the detector response to a highly supersonic polar wind flow. The detected ions' velocity distribution shows significant deviations from a shifted Maxwellian in the

Numerical Model of the Plasma Sheath Generated by the Plasma Source Instrument Aboard the Polar Satellite

NASA Technical Reports Server (NTRS)

Singh, N.; Leung, W. C.; Moore, T. E.; Craven, P. D.

2001-01-01

The plasma sheath generated by the operation of the Plasma Source Instrument (PSI) aboard the Polar satellite is studied by using a three-dimensional particle-in-cell (PIC) code. When the satellite passes through the region of low-density plasma, the satellite charges to positive potentials as high as 40-50 V, owing to the photoelectron emission. In such a case, ambient core ions cannot accurately be measured or detected. The goal of the onboard PSI is to reduce the floating potential of the satellite to a sufficiently low value so that the ions in the polar wind become detectable. When the PSI is operated, ion-rich xenon plasma is ejected from the satellite, such that the floating potential of the satellite is reduced and is maintained at approximately 2 V. Accordingly, in our three-dimensional PIC simulation we considered that the potential of the satellite is 2 V as a fixed bias. Considering the relatively high density of the xenon plasma in the sheath (10-10(exp 3)/cc), the ambient plasma of low density (<1/cc) is neglected. In the simulations the electric fields and plasma dynamics are calculated self-consistently. We found that an 'apple'-shape positive potential sheath forms surrounding the satellite. In the region near the PSI emission a high positive potential hill develops. Near the Thermal Ion Dynamics Experiment detector away from the PSI, the potentials are sufficiently low for the ambient polar wind ions to reach it. In the simulations it takes only about a couple of tens of electron gyroperiods for the sheath to reach a quasi steady state. This time is approximately the time taken by the heavy Xe(+) ions to expand up to about one average Larmor radius of electrons from the satellite surface. After this time the expansion of the sheath in directions transverse to the ambient magnetic field slows down because the electrons are magnetized. Using the quasi steady sheath, we performed trajectory calculations to characterize the detector response to a

Quantum shielding effects on the Gamow penetration factor for nuclear fusion reaction in quantum plasmas

NASA Astrophysics Data System (ADS)

Lee, Myoung-Jae; Jung, Young-Dae

2017-01-01

The quantum shielding effects on the nuclear fusion reaction process are investigated in quantum plasmas. The closed expression of the classical turning point for the Gamow penetration factor in quantum plasmas is obtained by the Lambert W-function. The closed expressions of the Gamow penetration factor and the cross section for the nuclear fusion reaction in quantum plasmas are obtained as functions of the plasmon energy and the relative kinetic energy by using the effective interaction potential with the WKB analysis. It is shown that the influence of quantum screening suppresses the Sommerfeld reaction factor. It is also shown that the Gamow penetration factor increases with an increase of the plasmon energy. It is also shown that the quantum shielding effect enhances the deuterium formation by the proton-proton reaction in quantum plasmas. In addition, it is found that the energy dependences on the reaction cross section and the Gamow penetration factor are more significant in high plasmon-energy domains.

Dynamics of a pulsed laser generated tin plasma expanding in an oxygen atmosphere

NASA Astrophysics Data System (ADS)

Barreca, F.; Fazio, E.; Neri, F.; Barletta, E.; Trusso, S.; Fazio, B.

2005-10-01

Semiconducting tin oxide can be successfully deposited by means of the laser ablation technique. In particular by ablating metallic tin in a controlled oxygen atmosphere, thin films of SnOx have been deposited. The partial oxygen pressure at which the films are deposited strongly influences both the stoichiometry and the structural properties of the films. In this work, we present a study of the expansion dynamics of the plasma generated by ablating a tin target by means of a pulsed laser using time and space resolved optical emission spectroscopy and fast photography imaging of the expanding plasma. Both Sn I and Sn II optical emission lines have been observed from the time-integrated spectroscopy. Time resolved-measurements revealed the dynamics of the expanding plasma in the ambient oxygen atmosphere. Stoichiometry of the films has been determined by means of X-ray photoelectron spectroscopy and correlated to the expansion dynamics of the plasma.

A reference protocol for comparing the biocidal properties of gas plasma generating devices

NASA Astrophysics Data System (ADS)

Shaw, A.; Seri, P.; Borghi, C. A.; Shama, G.; Iza, F.

2015-12-01

Growing interest in the use of non-thermal, atmospheric pressure gas plasmas for decontamination purposes has resulted in a multiplicity of plasma-generating devices. There is currently no universally approved method of comparing the biocidal performance of such devices and in the work described here spores of the Gram positive bacterium Bacillus subtilis (ATCC 6633) are proposed as a suitable reference biological agent. In order to achieve consistency in the form in which the biological agent in question is presented to the plasma, a polycarbonate membrane loaded with a monolayer of spores is proposed. The advantages of the proposed protocol are evaluated by comparing inactivation tests in which an alternative microorganism (methicillin resistant Staphylococcus aureus—MRSA) and the widely-used sample preparation technique of directly pipetting cell suspensions onto membranes are employed. In all cases, inactivation tests with either UV irradiation or plasma exposure were more reproducible when the proposed protocol was followed.

Effect of thermionic cathode heating current self-magnetic field on gaseous plasma generator characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopatin, I. V., E-mail: lopatin@opee.hcei.tsc.ru; Akhmadeev, Yu. H.; Koval, N. N.

2015-10-15

The performance capabilities of the PINK, a plasma generator with a thermionic cathode mounted in the cavity of a hollow cathode, depending for its operation on a non-self-sustained low-pressure gas discharge have been investigated. It has been shown that when a single-filament tungsten cathode 2 mm in diameter is used and the peak filament current is equal to or higher than 100 A, the self-magnetic field of the filament current significantly affects the discharge current and voltage waveforms. This effect is due to changes in the time and space distributions of the emission current density from the hot cathode. Whenmore » the electron mean free path is close to the characteristic dimensions of the thermionic cathode, the synthesized plasma density distribution is nonuniform and the cathode is etched nonuniformly. The cathode lifetime in this case is 8–12 h. Using a cathode consisting of several parallel-connected tungsten filaments ∼0.8 mm in diameter moderates the effect of the self-magnetic field of the filament current and nearly doubles the cathode lifetime. The use of this type of cathode together with a discharge igniting electrode reduces the minimum operating pressure in the plasma generator to about one third of that required for the generator operation with a single-filament cathode (to 0.04 Pa)« less

RF generator interlock by plasma grid bias current - An alternate to Hα interlock

NASA Astrophysics Data System (ADS)

Bandyopadhyay, M.; Gahlaut, A.; Yadav, R. K.; Pandya, K.; Tyagi, H.; Vupugalla, M.; Bhuyan, M.; Bhagora, J.; Chakraborty, A.

2017-08-01

ROBIN is inductively coupled plasma (ICP) based negative hydrogen ion source, operated with a 100kW, 1MHz Tetrode based RF generator (RFG). Inductive plasma ignition by the RFG in ROBIN is associated with electron seeding by a hot filament and a gas puff. RFG is triggered by the control system to deliver power just at the peak pressure of the gas puff. Once plasma is ignited due to proper impedance matching, a bright light, dominated by Hα (˜656nm wavelength) radiation is available inside RF driver which is used as a feedback signal to the RFG to continue its operation. If impedance matching is not correct, plasma is not produced due to lack of power coupling and bright light is not available. During such condition, reflected RF power may damage the RFG. Therefore, to protect the RFG, it needs to be switched off automatically within 200ms by the control system in such cases. This plasma light based RFG interlock is adopted from BATMAN ion source. However, in case of vacuum immersed RF ion source in reactor grade NBI system, such plasma light based interlock may not be feasible due to lack of adequate optical fiber interfaces. In reactor grade NBI system, neutron and gamma radiations have impact on materials which may lead to frequent maintenance and machine down time. The present demonstration of RFG interlock by Bias Current (BC) in ROBIN testbed gives an alternate option in this regard. In ROBIN, a bias plate (BP) is placed in the plasma chamber near the plasma grid (PG). BP is electrically connected to the plasma chamber wall of the ion source and PG is isolated from the wall. A high current ˜85 A direct current (DC) power supply of voltage in the range of 0 - 33V is connected between the PG and the BP in such a way that PG can be biased positively with respect to the BP or plasma chamber. This arrangement is actually made to absorb electrons and correspondingly reduce co-extracted electron current during beam extraction. However, in case of normal plasma

Plasma Modification of Poly Lactic Acid Solutions to Generate High Quality Electrospun PLA Nanofibers.

PubMed

Rezaei, Fatemeh; Nikiforov, Anton; Morent, Rino; De Geyter, Nathalie

2018-02-02

Physical properties of pre-electrospinning polymer solutions play a key role in electrospinning as they strongly determine the morphology of the obtained electrospun nanofibers. In this work, an atmospheric-pressure argon plasma directly submerged in the liquid-phase was used to modify the physical properties of poly lactic acid (PLA) spinning solutions in an effort to improve their electrospinnability. The electrical characteristics of the plasma were investigated by two methods; V-I waveforms and Q-V Lissajous plots while the optical emission characteristics of the plasma were also determined using optical emission spectroscopy (OES). To perform a complete physical characterization of the plasma-modified polymer solutions, measurements of viscosity, surface tension, and electrical conductivity were performed for various PLA concentrations, plasma exposure times, gas flow rates, and applied voltages. Moreover, a fast intensified charge-couple device (ICCD) camera was used to image the bubble dynamics during the plasma treatments. In addition, morphological changes of PLA nanofibers generated from plasma-treated PLA solutions were observed by scanning electron microscopy (SEM). The performed plasma treatments were found to induce significant changes to the main physical properties of the PLA solutions, leading to an enhancement of electrospinnability and an improvement of PLA nanofiber formation.

Influence of ionic liquid and ionic salt on protein against the reactive species generated using dielectric barrier discharge plasma.

PubMed

Attri, Pankaj; Sarinont, Thapanut; Kim, Minsup; Amano, Takaaki; Koga, Kazunori; Cho, Art E; Choi, Eun Ha; Shiratani, Masaharu

2015-12-10

The presence of salts in biological solution can affect the activity of the reactive species (RS) generated by plasma, and so they can also have an influence on the plasma-induced sterilization. In this work, we assess the influence that diethylammonium dihydrogen phosphate (DEAP), an ionic liquid (IL), and sodium chloride (NaCl), an ionic salt (IS), have on the structural changes in hemoglobin (Hb) in the presence of RS generated using dielectric barrier discharge (DBD) plasma in the presence of various gases [O2, N2, Ar, He, NO (10%) + N2 and Air]. We carry out fluorescence spectroscopy to verify the generation of (•)OH with or without the presence of DEAP IL and IS, and we use electron spin resonance (ESR) to check the generation of H(•) and (•)OH. In addition, we verified the structural changes in the Hb structure after treatment with DBD in presence and absence of IL and IS. We then assessed the structural stability of the Hb in the presence of IL and IS by using molecular dynamic (MD) simulations. Our results indicate that the IL has a strong effect on the conservation of the Hb structure relative to that of IS against RS generated by plasma.

Influence of ionic liquid and ionic salt on protein against the reactive species generated using dielectric barrier discharge plasma

NASA Astrophysics Data System (ADS)

Attri, Pankaj; Sarinont, Thapanut; Kim, Minsup; Amano, Takaaki; Koga, Kazunori; Cho, Art E.; Ha Choi, Eun; Shiratani, Masaharu

2015-12-01

The presence of salts in biological solution can affect the activity of the reactive species (RS) generated by plasma, and so they can also have an influence on the plasma-induced sterilization. In this work, we assess the influence that diethylammonium dihydrogen phosphate (DEAP), an ionic liquid (IL), and sodium chloride (NaCl), an ionic salt (IS), have on the structural changes in hemoglobin (Hb) in the presence of RS generated using dielectric barrier discharge (DBD) plasma in the presence of various gases [O2, N2, Ar, He, NO (10%) + N2 and Air]. We carry out fluorescence spectroscopy to verify the generation of •OH with or without the presence of DEAP IL and IS, and we use electron spin resonance (ESR) to check the generation of H• and •OH. In addition, we verified the structural changes in the Hb structure after treatment with DBD in presence and absence of IL and IS. We then assessed the structural stability of the Hb in the presence of IL and IS by using molecular dynamic (MD) simulations. Our results indicate that the IL has a strong effect on the conservation of the Hb structure relative to that of IS against RS generated by plasma.

The study of hard x-ray emission and electron beam generation in wire array Z-pinch and X-pinch plasmas at university-scale generators

NASA Astrophysics Data System (ADS)

Shrestha, Ishor Kumar

The studies of hard x-ray (HXR) emission and electron beam generation in Z-pinch plasmas are very important for Inertial Confinement Fusion (ICF) research and HXR emission application for sources of K-shell and L-shell radiation. Energetic electron beams from Z-pinch plasmas are potentially a problem in the development of ICF. The electron beams and the accompanying HXR emission can preheat the fuel of a thermonuclear target, thereby preventing the fuel compression from reaching densities required for the ignition of a fusion reaction. The photons above 3-4 keV radiated from a Z pinch can provide detailed information about the high energy density plasmas produced at stagnation. Hence, the investigation of characteristics of hard x-rays and electron beams produced during implosions of wire array loads on university scale-generators may provide important data for future ICF, sources of K-shell and L-shell radiations and basic plasma research. This dissertation presents the results of experimental studies of HXR and electron beam generation in wire-array and X-pinch on the 1.7 MA, 100-ns current rise time Zebra generator at University of Nevada, Reno and 1-MA 100-ns current rise-time Cornell Beam Research Accelerator (COBRA) at Cornell University. The experimental study of characteristics of HXR produced by multi-planar wire arrays, compact cylindrical wire array (CCWA) and nested cylindrical wire array (NCWA) made from Al, Cu, Mo, Ag, W and Au were analyzed. The dependence of the HXR yield and power on geometry of the load, the wire material, and load mass was observed. The presence of aluminum wires in the load with the main material such as stainless steel, Cu, Mo, Ag, W or Au in combined wire array decreases HXR yield. The comparison of emission characteristics of HXR and generation of electron beams in CCWA and NCWA on both the high impedance Zebra generator and low impedance COBRA generator were investigated. Some of the "cold" K- shell spectral lines (0.7-2.3�

Second harmonic generation of q-Gaussian laser beam in preformed collisional plasma channel with nonlinear absorption

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Naveen, E-mail: naveens222@rediffmail.com; Singh, Arvinder, E-mail: arvinder6@lycos.com; Singh, Navpreet, E-mail: navpreet.nit@gmail.com

2015-11-15

This paper presents a scheme for second harmonic generation of an intense q-Gaussian laser beam in a preformed parabolic plasma channel, where collisional nonlinearity is operative with nonlinear absorption. Due to nonuniform irradiance of intensity along the wavefront of the laser beam, nonuniform Ohmic heating of plasma electrons takes place. Due to this nonuniform heating of plasma, the laser beam gets self-focused and produces strong density gradients in the transverse direction. The generated density gradients excite an electron plasma wave at pump frequency that interacts with the pump beam to produce its second harmonics. The formulation is based on amore » numerical solution of the nonlinear Schrodinger wave equation in WKB approximation followed by moment theory approach. A second order nonlinear differential equation governing the propagation dynamics of the laser beam with distance of propagation has been obtained and is solved numerically by Runge Kutta fourth order technique. The effect of nonlinear absorption on self-focusing of the laser beam and conversion efficiency of its second harmonics has been investigated.« less

Generation and Sustainment of Plasma Rotation by ICRF Heating

NASA Astrophysics Data System (ADS)

Perkins, F. W.

2000-10-01

When tokamak plasmas are heated by the fundamental minority ion-cyclotron process, they are observed to rotate toroidally, even though this heating process introduces negligable angular momentum. This work proposes and evaluates a physics mechanism which resolves this apparent conflict. The argument has two elements. First, it is assumed that angular momentum transport is governed by a diffusion equation with a v_tor = 0 boundary condition at the plasma surface and a torque-density source. When the source consists of separated regions of positive and negative torque density, a finite central rotation velocity results, even though the volume integrated torque density - the angular momentum input - vanishes. Secondly, ions energized by the ICRF process can generate separated regions of positive and negative torque density. Heating increases their banana widths which leads to radial energetic-particle transport that must be balanced by neutralizing radial currents and a j_rB_pR torque density in the bulk plasma. Additional, comparable torque density results from collisional transfer of mechanical angular momentum from energetic particles to the bulk plasma and particle loss through banana particles impacting the wall. Monte-Carlo calculations utilizing the ORBIT code evaluate all sources of torque density and rigorously assure that no net angular momentum is introduced. Two models of ICRF heating, diffusive and instantaneous, give similar results. When the resonance location is on the LFS, the calculated rotation has the magnitude, profile, and co-current sense of Alcator C-Mod observations. For HFS resonance locations, the model predicts counter-current rotation. Scans of rotational profiles vs. resonance location, initial energy, particle loss, pitch, and qm will be presented as will the location of the velocity shear layer its scaling to a reactor.

Advanced Thomson scattering system for high-flux linear plasma generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meiden, H. J. van der; Lof, A. R.; Berg, M. A. van den

2012-12-15

An advanced Thomson scattering system has been built for a linear plasma generator for plasma surface interaction studies. The Thomson scattering system is based on a Nd:YAG laser operating at the second harmonic and a detection branch featuring a high etendue (f /3) transmission grating spectrometer equipped with an intensified charged coupled device camera. The system is able to measure electron density (n{sub e}) and temperature (T{sub e}) profiles close to the output of the plasma source and, at a distance of 1.25 m, just in front of a target. The detection system enables to measure 50 spatial channels ofmore » about 2 mm each, along a laser chord of 95 mm. By summing a total of 30 laser pulses (0.6 J, 10 Hz), an observational error of 3% in n{sub e} and 6% in T{sub e} (at n{sub e}= 9.4 Multiplication-Sign 10{sup 18} m{sup -3}) can be obtained. Single pulse Thomson scattering measurements can be performed with the same accuracy for n{sub e} > 2.8 Multiplication-Sign 10{sup 20} m{sup -3}. The minimum measurable density and temperature are n{sub e} < 1 Multiplication-Sign 10{sup 17} m{sup -3} and T{sub e} < 0.07 eV, respectively. In addition, using the Rayleigh peak, superimposed on the Thomson scattered spectrum, the neutral density (n{sub 0}) of the plasma can be measured with an accuracy of 25% (at n{sub 0}= 1 Multiplication-Sign 10{sup 20} m{sup -3}). In this report, the performance of the Thomson scattering system will be shown along with unprecedented accurate Thomson-Rayleigh scattering measurements on a low-temperature argon plasma expansion into a low-pressure background.« less

The diagnostic value of plasma N-terminal connective tissue growth factor levels in children with heart failure.

PubMed

Li, Gang; Song, Xueqing; Xia, Jiyi; Li, Jing; Jia, Peng; Chen, Pengyuan; Zhao, Jian; Liu, Bin

2017-01-01

The aim of this study was to assess the diagnostic value of plasma N-terminal connective tissue growth factor in children with heart failure. Methods and results Plasma N-terminal connective tissue growth factor was determined in 61 children, including 41 children with heart failure, 20 children without heart failure, and 30 healthy volunteers. The correlations between plasma N-terminal connective tissue growth factor levels and clinical parameters were investigated. Moreover, the diagnostic value of N-terminal connective tissue growth factor levels was evaluated. Compared with healthy volunteers and children without heart failure, plasma N-terminal connective tissue growth factor levels were significantly elevated in those with heart failure (p0.05), but it obviously improved the ability of diagnosing heart failure in children, as demonstrated by the integrated discrimination improvement (6.2%, p=0.013) and net re-classification improvement (13.2%, p=0.017) indices. Plasma N-terminal connective tissue growth factor is a promising diagnostic biomarker for heart failure in children.

Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects.

PubMed

Hsia, Chien-Hsun; Shen, Ming-Ching; Lin, Jen-Shiou; Wen, Yao-Ke; Hwang, Kai-Lin; Cham, Thau-Ming; Yang, Nae-Cherng

2009-03-01

Nattokinase, a serine proteinase from Bacillus subtilis, is considered to be one of the most active functional ingredients found in natto. In this study, we hypothesized that nattokinase could reduce certain factors of blood clotting and lipids that are associated with an increase risk for cardiovascular disease (CVD). Thus, an open-label, self-controlled clinical trial was conducted on subjects of the following groups: healthy volunteers (Healthy Group), patients with cardiovascular risk factors (Cardiovascular Group), and patients undergoing dialysis (Dialysis Group). All subjects ingested 2 capsules of nattokinase (2000 fibrinolysis units per capsule) daily orally for 2 months. The laboratory measurements were performed on the screening visit and, subsequently, regularly after the initiation of the study. The intent-to-treat analysis was performed on all 45 enrolled subjects. By use of mixed model analysis, a significant time effect, but not group effect, was observed in the change from baseline of fibrinogen (P = .003), factor VII (P < .001), and factor VIII (P < .001), suggesting that the plasma levels of the 3 coagulation factors continuously declined during intake; also, the extents of decrease were similar between groups. After 2 months of administration, fibrinogen, factor VII, and factor VIII decreased 9%, 14%, and 17%, respectively, for the Healthy Group; 7%, 13%, and 19%, respectively, for the Cardiovascular Group; and 10%, 7%, and 19%, respectively, for the Dialysis Group, whereas blood lipids were unaffected by nattokinase. No significant changes of uric acid or notable adverse events were observed in any of the subjects. In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII.

Environmental and Genetic Factors Regulating Localization of the Plant Plasma Membrane H+-ATPase.

PubMed

Haruta, Miyoshi; Tan, Li Xuan; Bushey, Daniel B; Swanson, Sarah J; Sussman, Michael R

2018-01-01

A P-type H + -ATPase is the primary transporter that converts ATP to electrochemical energy at the plasma membrane of higher plants. Its product, the proton-motive force, is composed of an electrical potential and a pH gradient. Many studies have demonstrated that this proton-motive force not only drives the secondary transporters required for nutrient uptake, but also plays a direct role in regulating cell expansion. Here, we have generated a transgenic Arabidopsis ( Arabidopsis thaliana ) plant expressing H + -ATPase isoform 2 (AHA2) that is translationally fused with a fluorescent protein and examined its cellular localization by live-cell microscopy. Using a 3D imaging approach with seedlings grown for various times under a variety of light intensities, we demonstrate that AHA2 localization at the plasma membrane of root cells requires light. In dim light conditions, AHA2 is found in intracellular compartments, in addition to the plasma membrane. This localization profile was age-dependent and specific to cell types found in the transition zone located between the meristem and elongation zones. The accumulation of AHA2 in intracellular compartments is consistent with reduced H + secretion near the transition zone and the suppression of root growth. By examining AHA2 localization in a knockout mutant of a receptor protein kinase, FERONIA, we found that the intracellular accumulation of AHA2 in the transition zone is dependent on a functional FERONIA-dependent inhibitory response in root elongation. Overall, this study provides a molecular underpinning for understanding the genetic, environmental, and developmental factors influencing root growth via localization of the plasma membrane H + -ATPase. © 2018 American Society of Plant Biologists. All Rights Reserved.

Design and development of a low cost, high current density power supply for streamer free atmospheric pressure DBD plasma generation in air.

PubMed

Jain, Vishal; Visani, Anand; Srinivasan, R; Agarwal, Vivek

2018-03-01

This paper presents a new power supply architecture for generating a uniform dielectric barrier discharge (DBD) plasma in air medium at atmospheric pressure. It is quite a challenge to generate atmospheric pressure uniform glow discharge plasma, especially in air. This is because air plasma needs very high voltage for initiation of discharge. If the high voltage is used along with high current density, it leads to the formation of streamers, which is undesirable for most applications like textile treatment, etc. Researchers have tried to generate high-density plasma using a RF source, nanosecond pulsed DC source, and medium frequency AC source. However, these solutions suffer from low current discharge and low efficiency due to the addition of an external resistor to control the discharge current. Moreover, they are relatively costly and bulky. This paper presents a new power supply configuration which is very compact and generates high average density (∼0.28 W/cm 2 ) uniform glow DBD plasma in air at atmospheric pressure. The efficiency is also higher as no external resistor is required to control the discharge current. An inherent feature of this topology is that it can drive higher current oscillations (∼50 A peak and 2-3 MHz frequency) into the plasma that damp out due to the plasma dissipation only. A newly proposed model has been used with experimental validation in this paper. Simulations and experimental validation of the proposed topology are included. Also, the application of the generated plasma for polymer film treatment is demonstrated.

Design and development of a low cost, high current density power supply for streamer free atmospheric pressure DBD plasma generation in air

NASA Astrophysics Data System (ADS)

Jain, Vishal; Visani, Anand; Srinivasan, R.; Agarwal, Vivek

2018-03-01

This paper presents a new power supply architecture for generating a uniform dielectric barrier discharge (DBD) plasma in air medium at atmospheric pressure. It is quite a challenge to generate atmospheric pressure uniform glow discharge plasma, especially in air. This is because air plasma needs very high voltage for initiation of discharge. If the high voltage is used along with high current density, it leads to the formation of streamers, which is undesirable for most applications like textile treatment, etc. Researchers have tried to generate high-density plasma using a RF source, nanosecond pulsed DC source, and medium frequency AC source. However, these solutions suffer from low current discharge and low efficiency due to the addition of an external resistor to control the discharge current. Moreover, they are relatively costly and bulky. This paper presents a new power supply configuration which is very compact and generates high average density (˜0.28 W/cm2) uniform glow DBD plasma in air at atmospheric pressure. The efficiency is also higher as no external resistor is required to control the discharge current. An inherent feature of this topology is that it can drive higher current oscillations (˜50 A peak and 2-3 MHz frequency) into the plasma that damp out due to the plasma dissipation only. A newly proposed model has been used with experimental validation in this paper. Simulations and experimental validation of the proposed topology are included. Also, the application of the generated plasma for polymer film treatment is demonstrated.

Reduced plasma levels of coagulation factors in relation to prostate cancer.

PubMed

Beecken, Wolf-Dietrich; Bentas, Wassilios; Engels, Knut; Glienke, Wolfgang; Urbschat, Anja; Jonas, Dietger; Binder, Jochen; Scharrer, Inge

2002-10-01

Prostate cancer has historically been associated with coagulation abnormalities. This study was undertaken to investigate the prevalence of abnormalities of coagulation factors in patients with prostate cancer before and after radical prostatectomy (RP). Because coagulation factors have been shown to be involved in tumor angiogenesis, the vascular density of the prostate tumors was assessed. Plasma of 40 consecutive patients with histologically proven prostate cancer was investigated pre-RP and post-RP. The antigen level for antithrombin, plasminogen activator inhibitor-1, and heparin cofactor-II, and the plasma activity of antithrombin and plasminogen were determined by using immunologic and chromogenic assays. The values of these assays were compared with a group of 28 male, age-matched patients without any evidence of cancer and 18 patients with orthopedic interventions preoperatively and postoperatively. The vascular density of the prostate tumors was assessed by staining paraffin sections with an antibody to CD34. The median plasma antigen levels and/or activities of the investigated factors were below normal in the prostate cancer patients before RP. Furthermore, coagulation factors were significantly lower than in the age-matched control group and patients before and after orthopedic surgery. In prostate cancer patients, the median values of all investigated factors went up to normal levels within 2 weeks after RP, whereas postsurgical levels in orthopedic patients remained stable. No correlations to tumor parameters have been observed. We assume that the reduction of these coagulation factors is a principle concept in prostate cancer that needs further investigation. Copyright 2002 Wiley-Liss, Inc.

Plasma convection and ion beam generation in the plasma sheet boundary layer

NASA Technical Reports Server (NTRS)

Moghaddam-Taaheri, E.; Goertz, C. K.; Smith, R. A.

1991-01-01

Because of the dawn-dusk electric field E(dd), plasma in the magnetotail convects from the lobe toward the central plasma sheet (CPS). In the absence of space or velocity diffusion due to plasma turbulence, convection would yield a steady state distribution function f = V exp (-2/3) g(v exp 2 V exp 2/3), where V is the flux tube volume. Starting with such a distribution function and a plasma beta which varies from beta greater than 1 in the CPS to beta much smaller than 1 in the lobe, the evolution of the ion distribution function was studied considering the combined effects of ion diffusion by kinetic Alfven waves (KAW) in the ULF frequency range (1-10 mHz) and convection due to E(dd) x B drift in the plasma sheet boundary layer (PSBL) and outer central plasma sheet (OCPS). The results show that, during the early stages after launching the KAWs, a beamlike ion distribution forms in the PSBL and at the same time the plasma density and temperature decrease in the OCPS. Following this stage, ions in the beams convect toward the CPS resulting in an increase of the plasma temperature in the OCPS.

Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma.

PubMed

van Beers, J J B C; van Egmond, L T; Wetzels, R J H; Verhezen, P W M; Beckers, E A M; van Oerle, R; Spronk, H M H; Straat, R J M H E; Henskens, Y M C

2016-07-01

In this study, differences in levels of proteins involved in coagulation and fibrinolysis were compared between fresh frozen (quarantine plasma) and Omniplasma. Furthermore, thawing conditions and plasma stability after thawing were studied. 10 Omniplasma and 10 quarantine plasma units were used to study different procoagulation, anticoagulation and fibrinolytic parameters. Analysis took place at different time-points during plasma storage at 2-6°C. At baseline, significant reduced levels of factor V, free protein S, α2-antiplasmin and tPA-induced ROTEM lysis time were observed in Omniplasma as compared to quarantine plasma. Moreover, thrombin generation, IXa-AT complex levels and factor XIa were significantly increased in Omniplasma. The majority of the parameters studied remained stable in Omniplasma 48 h after thawing, with the exception of factor VIII (decrease) and IXa-AT (increase). Our results suggest an increased coagulation potential, presumingly as a result of contact activation during the production process and also, an increased fibrinolytic potential in Omniplasma. The stability of Omniplasma, based upon the different parameters studied, is comparable to Q-plasma. A maximum post-thawing time of 48 hfor Omniplasma can be suggested. © 2016 International Society of Blood Transfusion.

REVIEWS OF TOPICAL PROBLEMS: Instabilities of a multicomponent plasma with accelerated particles and magnetic field generation in astrophysical objects

NASA Astrophysics Data System (ADS)

Bykov, Andrei M.; Toptygin, Igor'N.

2007-02-01

A system of MHD equations for the description of a magnetized nonequilibrium astrophysical plasma with neutral atoms and suprathermal (in particular, relativistic) particles is formulated. The instabilities of such a plasma, which arise from the presence of neutral and relativistic components, are considered. It is shown that the presence of nonthermal particles interacting with the thermal plasma component via regular and fluctuating electromagnetic fields is responsible for the emergence of specific mechanisms of MHD wave generation. The main generation mechanisms of static and turbulent magnetic fields near shock wave fronts in the Galaxy and interplanetary space are analyzed. We discuss the application of the generation effects of long-wave magnetic fluctuations to the problems of magnetic field origin and relativistic particle acceleration in astrophysical objects of various natures.

Racial and genetic determinants of plasma factor XIII activity.

PubMed

Saha, N; Aston, C E; Low, P S; Kamboh, M I

2000-12-01

Factor XIII (F XIII), a plasma transglutaminase, is essential for normal hemostasis and fibrinolysis. Plasma F XIII consists of two catalytic A (F XIIIA) and two non-catalytic B (F XIIIB) subunits. Activated F XIII is involved in the formation of fibrin gel by covalently crosslinking fibrin monomers. As the characteristics of the fibrin gel structure have been shown to be associated with the risk of coronary heart disease (CHD), F XIII activity may play a seminal role in its etiology. In this investigation, we determined plasma F XIII activity in two racial groups, including Asian Indians (n = 258) and Chinese (n = 385). Adjusted plasma F XIII activity was significantly higher in Indian men (142 vs. 110%; P<0.0001) and women (158 vs. 111%; P<0.0001) than their Chinese counterparts. As compared to Indians where the distribution of F XIII activity was almost normal, in Chinese it was skewed towards low activity. In both racial groups, bivariate and multivariate analyses showed strong correlation of F XIII activity with plasma fibrinogen and plasminogen levels. Race explained about 25% of the variation in F XIII activity even after the adjustment of significant correlates. We also determined the contribution of common genetic polymorphisms in the F XIIIA and F XIIIB genes in affecting plasma F XIII activity. Both loci showed significant and independent effects on plasma F XIII activity in Indians (F XIIIA, P< 0.01; F XIIIB, P<0.05) and Chinese (F XIIIA, P<0.0001; F XIIIB, P<0.13) in a gene dosage fashion. This study shows that both racial and genetic components play a significant role in determining plasma F XIII activity, and consequently it may affect the quantitative risk of CHD. Copyright 2000 Wiley-Liss, Inc.

Effect of platelet activating factor on endothelial permeability to plasma macromolecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Handley, D.A.; Arbeeny, C.M.; Lee, M.L.

The effect of intrajugular administration of platelet activating factor (PAF-C16) on vascular permeability was examined in the guinea pig. To examine the loss of selective endothelial permeability, the extravasative effect of PAF was assessed by monitoring hemoconcentration and the plasma loss of /sup 125/I-albumin (6.7 nm), /sup 125/I-low density lipoproteins (22.0 nm) or /sup 125/I-very low density lipoproteins (62.1 nm). Extravasation was dose-dependent and began 1 min after PAF administration, continuing for 5-7 min. During extravasation, there was no evidence for selective plasma retention of any of the labeled plasma tracers, as measured by plasma radioactivity. These results suggest thatmore » PAF-induced extravasation is dose-dependent, with increases in vascular permeability sufficient to permit similar plasma efflux rates of albumin, low density lipoproteins and very low density lipoproteins.« less

Psoriasis is associated with decreased plasma adiponectin levels independently of cardiometabolic risk factors

PubMed Central

Li, R. C.; Krishnamoorthy, P.; DerOhannessian, S.; Doveikis, J.; Wilcox, M.; Thomas, P.; Rader, D. J.; Reilly, M. P.; Voorhees, A. Van; Gelfand, J. M.; Mehta, N. N.

2013-01-01

Summary Background Psoriasis is an inflammatory skin disease that may be associated with an adverse cardiometabolic profile including modulated plasma adiponectin and leptin levels. Whether these levels are independent of cardiometabolic risk factors, which are also prevalent in psoriasis, is not known. Methods A consecutive sample of 122 participants with varying degrees of psoriasis severity, and a random sample of 134 participants without psoriasis were recruited for this case–control study. Cardiometabolic risk factors including traditional cardiovascular risk factors, waist circumference, insulin resistance, and total plasma adiponectin and leptin were measured. Total plasma adiponectin and leptin levels were compared in unadjusted and adjusted analyses by psoriasis status. Results Participants with psoriasis had mostly mild disease and were mainly on topical therapies, but still had a more adverse cardiometabolic profile compared with those without psoriasis. Furthermore, plasma adiponectin levels were significantly lower in participants with psoriasis than those without {7.13 µg/mL [interquartile range (IQR) 4.9–11.3) vs. 14.5 µg/mL (IQR 8.4–24.1); P < 0.001]}. Plasma leptin (ng/mL) levels were higher in the psoriasis group but this did not reach statistical significance [11.3 (IQR 6.4–21.8) vs. 9.8 (IQR 4.9–20.5); P = 0.07]. In multivariable modelling, plasma adiponectin levels were still negatively associated with psoriasis status after adjusting for waist size (% difference = −41.2%, P < 0.001), insulin resistance (% difference = −39.5%, P < 0.001) and both waist size and insulin resistance (% difference = −38.5%, P < 0.001) Conclusion Plasma levels of adiponectin were lower in psoriasis, and this relationship persisted after adjusting for cardiometabolic risk factors known to decrease adiponectin levels. These findings suggest that inflammation present in psoriasis may be associated with adipose tissue dysfunction; however, direct

Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

PubMed Central

Altman, Raul; Scazziota, Alejandra Silvia; Herrera, Maria de Lourdes; Gonzalez, Claudio

2006-01-01

Background Platelet activation is crucial in normal hemostasis. Using a clotting system free of external tissue factor, we investigated whether activated Factor VII in combination with platelet agonists increased thrombin generation (TG) in vitro. Methods and results TG was quantified by time parameters: lag time (LT) and time to peak (TTP), and by amount of TG: peak of TG (PTG) and area under thrombin formation curve after 35 minutes (AUC→35min) in plasma from 29 healthy volunteers using the calibrated automated thrombography (CAT) technique. TG parameters were measured at basal conditions and after platelet stimulation by sodium arachidonate (AA), ADP, and collagen (Col). In addition, the effects of recombinant activated FVII (rFVIIa) alone or combined with the other platelet agonists on TG parameters were investigated. We found that LT and TTP were significantly decreased (p < 0.05) and PTG and AUC→35min were significantly increased (p < 0.05) in platelet rich plasma activated with AA, ADP, Col, and rFVIIa compared to non-activated platelet rich plasma from normal subjects (p = 0.01). Furthermore platelet rich plasma activated by the combined effects of rFVIIa plus AA, ADP or Col had significantly reduced LT and TTP and increased AUC→35min (but not PTG) when compared to platelet rich plasma activated with agonists in the absence of rFVIIa. Conclusion Platelets activated by AA, ADP, Col or rFVIIa triggered TG. This effect was increased by combining rFVIIa with other agonists. Our intrinsic coagulation system produced a burst in TG independent of external tissue factor activity an apparent hemostatic effect with little thrombotic capacity. Thus we suggest a modification in the cell-based model of hemostasis. PMID:16630353

Study of magnetic field expansion using a plasma generator for space radiation active protection

NASA Astrophysics Data System (ADS)

Jia, Xiang-Hong; Jia, Shao-Xia; Xu, Feng; Bai, Yan-Qiang; Wan, Jun; Liu, Hong-Tao; Jiang, Rui; Ma, Hong-Bo; Wang, Shou-Guo

2013-09-01

There are many active protecting methods including Electrostatic Fields, Confined Magnetic Field, Unconfined Magnetic Field and Plasma Shielding etc. for defending the high-energy solar particle events (SPE) and Galactic Cosmic Rays (GCR) in deep space exploration. The concept of using cold plasma to expand a magnetic field is the best one of all possible methods so far. The magnetic field expansion caused by plasma can improve its protective efficiency of space particles. One kind of plasma generator has been developed and installed into the cylindrical permanent magnet in the eccentric. A plasma stream is produced using a helical-shaped antenna driven by a radio-frequency (RF) power supply of 13.56 MHz, which exits from both sides of the magnet and makes the magnetic field expand on one side. The discharging belts phenomenon is similar to the Earth's radiation belt, but the mechanism has yet to be understood. A magnetic probe is used to measure the magnetic field expansion distributions, and the results indicate that the magnetic field intensity increases under higher increments of the discharge power.

Generation of a nonequlibrium plasma in heterophase atmospheric-pressure gas-liquid media and demonstration of its sterilization ability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akishev, Yu. S.; Grushin, M. E.; Karal'nik, V. B.

Results are presented from experiments on the generation of a low-temperature nonequilibrium plasma in atmospheric-pressure heterophase gas-liquid media of different compositions: (i) a liquid with air bubbles and (ii) air with liquid aerosol. To illustrate possible application of a low-temperature plasma in a heterophase medium, experiments on the inactivation of some microorganisms by a low-temperature plasma have been performed.

Detailed study of spontaneous rotation generation in diverted H-mode plasma using the full-f gyrokinetic code XGC1

NASA Astrophysics Data System (ADS)

Seo, Janghoon; Chang, C. S.; Ku, S.; Kwon, J. M.; Yoon, E. S.

2013-10-01

The Full-f gyrokinetic code XGC1 is used to study the details of toroidal momentum generation in H-mode plasma. Diverted DIII-D geometry is used, with Monte Carlo neutral particles that are recycled at the limiter wall. Nonlinear Coulomb collisions conserve particle, momentum, and energy. Gyrokinetic ions and adiabatic electrons are used in the present simulation to include the effects from ion gyrokinetic turbulence and neoclassical physics, under self-consistent radial electric field generation. Ion orbit loss physics is automatically included. Simulations show a strong co-Ip flow in the H-mode layer at outside midplane, similarly to the experimental observation from DIII-D and ASDEX-U. The co-Ip flow in the edge propagates inward into core. It is found that the strong co-Ip flow generation is mostly from neoclassical physics. On the other hand, the inward momentum transport is from turbulence physics, consistently with the theory of residual stress from symmetry breaking. Therefore, interaction between the neoclassical and turbulence physics is a key factor in the spontaneous momentum generation.

Association between lifestyle factors and plasma adiponectin levels in Japanese men.

PubMed

Tsukinoki, Rumi; Morimoto, Kanehisa; Nakayama, Kunio

2005-11-02

Adiponectin is an adipocyte-specific protein that plays a role in obesity, insulin resistant, lipid metabolism, and anti-inflammation. Hypoadiponectinemia may be associated with a higher risk for type 2 diabetes and cardiovascular disease. Some studies suggest that adiponectin levels are modulated by lifestyle factors, but little is known about the associations between lifestyle factors and plasma adiponectin levels in Japanese people. We therefore investigated the associations between lifestyle factors and plasma adiponectin levels in general Japanese men. The subjects were 202 Japanese male workers who participated in an annual health check. They provided details about anthropometrical data, blood collection, their use of prescribed medication, and the clinical history of their families. They also completed a self-administered questionnaire about their lifestyles. Subjects with plasma adiponectin levels below 4.0 microg/ml had significantly lower levels of HDL cholesterol and higher levels of BMI, SBP, DBP, total cholesterol, FBG, and platelets than did subjects with higher adiponectin levels. In multiple logistic regression after multiple adjustment, a plasma adiponectin level below 4.0 microg/ml was significantly associated with smoking (odds ratio [OR] = 2.08, 95% confidence interval [CI] = 1.01-4.30), a daily diet rich in deep-yellow vegetables (OR = 0.25, 95% CI= 0.07-0.91), frequent eating out (OR = 2.45, 95% CI = 1.19-5.08), and physical exercise two or more times a week (OR = 0.21, 95% CI = 0.06-0.74). Our findings show that adiponectin levels in general Japanese men are independently related to smoking, dietary factors, and physical exercise. We think that lifestyle habits might independently modulate adiponectin levels and that adiponectin might be the useful biomarker helping people to avoid developing type 2 diabetes and cardiovascular disease by modifying their lifestyles.

Ion Beam And Plasma Jet Generated By A 3 kJ Plasma Focus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, L. K.; Ngoi, S. K.; Yap, S. L.

The plasma focus device is well known as a copious source of X-ray, neutrons, ion and electron beams. In this work, the characteristics of energetic ion beam emission in a 3 kJ Mather-type plasma focus is studied. The plasma focus system is operated at low pressure with argon as the working gas. The objective of the project is to obtain the argon ion beam and the plasma jet. The ion beam and plasma jet are used for material processing. In order to investigate the effect of the ion beam and plasma jet, crystalline silicon substrates are placed above the anode.more » Samples obtained after irradiation with the plasma focus discharge are analyzed by using the Scanning electron microscopy (SEM) and Energy Dispersive X-ray spectroscopy (EDX).« less

Terahertz generation by relativistic ponderomotive focusing of two co-axial Gaussian laser beams propagating in ripple density plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Subodh; Singh, Ram Kishor, E-mail: ram007kishor@gmail.com; Sharma, R. P.

Terahertz (THz) generation by beating of two co-axial Gaussian laser beams, propagating in ripple density plasma, has been studied when both ponderomotive and relativistic nonlinearities are operative. When the two lasers co-propagate in rippled density plasma, electrons acquire a nonlinear velocity at beat frequency in the direction transverse to the direction of propagation. This nonlinear oscillatory velocity couples with the density ripple to generate a nonlinear current, which in turn generates THz radiation at the difference frequency. The necessary phase matching condition is provided by the density ripple. Relativistic ponderomotive focusing of the two lasers and its effects on yieldmore » of the generated THz amplitude have been discussed. Numerical results show that conversion efficiency of the order of 10{sup −3} can be achieved in the terahertz radiation generation with relativistic ponderomotive focusing.« less

Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems

PubMed Central

Kaushik, Neha; Uddin, Nizam; Sim, Geon Bo; Hong, Young June; Baik, Ku Youn; Kim, Chung Hyeok; Lee, Su Jae; Kaushik, Nagendra Kumar; Choi, Eun Ha

2015-01-01

In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2−), hydroxyl radical (HO·), and hydrogen peroxide (H2O2) with chemicals inside an in vitro cell culture. Our data revealed that plasma decreased the viability and intracellular ATP values of cells and increased the apoptotic population via a caspase activation mechanism. Plasma altered the mitochondrial membrane potential and eventually up-regulated the mRNA expression levels of BAX, BAK1 and H2AX gene but simultaneously down-regulated the levels of Bcl-2 in solid tumor cells. Moreover, a western blot analysis confirmed that plasma also altered phosphorylated ERK1/2/MAPK protein levels. At the same time, using ROS scavengers with plasma, we observed that scavengers of HO· (mannitol) and H2O2 (catalase and sodium pyruvate) attenuated the activity of plasma on cells to a large extent. In contrast, radicals generated by specific chemical systems enhanced cell death drastically in cancer as well as normal cell lines in a dose-dependent fashion but not specific with regard to the cell type as compared to plasma. PMID:25715710

Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems

NASA Astrophysics Data System (ADS)

Kaushik, Neha; Uddin, Nizam; Sim, Geon Bo; Hong, Young June; Baik, Ku Youn; Kim, Chung Hyeok; Lee, Su Jae; Kaushik, Nagendra Kumar; Choi, Eun Ha

2015-02-01

In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma, we generated superoxide anion (O2-), hydroxyl radical (HO.), and hydrogen peroxide (H2O2) with chemicals inside an in vitro cell culture. Our data revealed that plasma decreased the viability and intracellular ATP values of cells and increased the apoptotic population via a caspase activation mechanism. Plasma altered the mitochondrial membrane potential and eventually up-regulated the mRNA expression levels of BAX, BAK1 and H2AX gene but simultaneously down-regulated the levels of Bcl-2 in solid tumor cells. Moreover, a western blot analysis confirmed that plasma also altered phosphorylated ERK1/2/MAPK protein levels. At the same time, using ROS scavengers with plasma, we observed that scavengers of HO. (mannitol) and H2O2 (catalase and sodium pyruvate) attenuated the activity of plasma on cells to a large extent. In contrast, radicals generated by specific chemical systems enhanced cell death drastically in cancer as well as normal cell lines in a dose-dependent fashion but not specific with regard to the cell type as compared to plasma.

Effects of recombinant human prothrombin on thrombin generation in plasma from patients with hemophilia A and B.

PubMed

Hansson, K M; Gustafsson, D; Skärby, T; Frison, L; Berntorp, E

2015-07-01

The present study was carried out to investigate the impact of FII levels, and their increase, on the hemostatic potential in plasma from hemophilia A and B patients with and without inhibitors. Recombinant human factor (F) II (rhFII) was added ex vivo to plasma from 68 patients with hemophilia A and B, with or without inhibitors. The hemostatic potential as measured by thrombin generation (calibrated automated thrombogram [CAT]) was focused on the endogenous thrombin potential (ETP) as it has been shown to correlate with the clinical phenotype of bleeding in hemophilia patients and has also been used to guide bypassing therapy in hemophilia patients with inhibitors before elective surgery. The factor eight inhibitor bypassing agent (FEIBA(®) ) was used as a reference to the clinical situation. The study shows that rhFII concentration-dependently increased ETP by a similar magnitude in hemophilia A and B, both with and without inhibitors. Compared with FEIBA, rhFII showed a shallower concentration-response curve. In both types of hemophilia 100 mg L(-1) of rhFII roughly doubled the ETP. A corresponding response was obtained by 0.5 U mL(-1) of FEIBA. These data support the theory that FII is one of the major components responsible for the efficacy of FEIBA. The data also indicate that rhFII may be useful, alone or in combination with other coagulation factors, in some of the conditions for which FEIBA is used today, although more data are needed to substantiate this. © 2015 International Society on Thrombosis and Haemostasis.

Intense isolated attosecond pulse generation from relativistic laser plasmas using few-cycle laser pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Guangjin, E-mail: guangjin.ma@mpq.mpg.de; Max-Planck-Institut für Quantenoptik, D-85748 Garching; Dallari, William

2015-03-15

We have performed a systematic study through particle-in-cell simulations to investigate the generation of attosecond pulse from relativistic laser plasmas when laser pulse duration approaches the few-cycle regime. A significant enhancement of attosecond pulse energy has been found to depend on laser pulse duration, carrier envelope phase, and plasma scale length. Based on the results obtained in this work, the potential of attaining isolated attosecond pulses with ∼100 μJ energy for photons >16 eV using state-of-the-art laser technology appears to be within reach.

The measurement of insulin-like growth factor 1 in sheep plasma.

PubMed

Bruce, L A; Atkinson, T; Hutchinson, J S; Shakespear, R A; MacRae, J C

1991-02-01

A method is described for the radioimmunoassay (RIA) of insulin-like growth factor 1 (IGF-1) in neutralised formic acid-ethanol extracts of sheep plasma. The ability of the acid-ethanol pretreatment to remove the IGF-1 binding proteins (BPs), which interfere in the assay has been examined. Comparative plasma IGF-1 concentrations determined by the method correlated closely (P less than 0.001) with corresponding values where BPs were removed by acid gel filtration. The method has been applied to studies in which sheep were given exogenous growth hormone and indicated that plasma IGF-1 levels respond rapidly to the onset and termination of treatment.

The plasma filling factor of coronal bright points. II. Combined EIS and TRACE results

NASA Astrophysics Data System (ADS)

Dere, K. P.

2009-04-01

Aims: In a previous paper, the volumetric plasma filling factor of coronal bright points was determined from spectra obtained with the Extreme ultraviolet Imaging Spectrometer (EIS). The analysis of these data showed that the median plasma filling factor was 0.015. One interpretation of this result was that the small filling factor was consistent with a single coronal loop with a width of 1-2´´, somewhat below the apparent width. In this paper, higher spatial resolution observations with the Transition Region and Corona Explorer (TRACE) are used to test this interpretation. Methods: Rastered spectra of regions of the quiet Sun were recorded by the EIS during operations with the Hinode satellite. Many of these regions were simultaneously observed with TRACE. Calibrated intensities of Fe xii lines were obtained and images of the quiet corona were constructed from the EIS measurements. Emission measures were determined from the EIS spectra and geometrical widths of coronal bright points were obtained from the TRACE images. Electron densities were determined from density-sensitive line ratios measured with EIS. A comparison of the emission measure and bright point widths with the electron densities yielded the plasma filling factor. Results: The median electron density of coronal bright points is 3 × 109 cm-3 at a temperature of 1.6 × 106 K. The volumetric plasma filling factor of coronal bright points was found to vary from 3 × 10-3 to 0.3 with a median value of 0.04. Conclusions: The current set of EIS and TRACE coronal bright-point observations indicate the median value of their plasma filling factor is 0.04. This can be interpreted as evidence of a considerable subresolution structure in coronal bright points or as the result of a single completely filled plasma loop with widths on the order of 0.2-1.5´´ that has not been spatially resolved in these measurements.

Evaluation of factors important in modeling plasma concentrations of tetracycline hydrochloride administered in water in swine.

PubMed

Mason, Sharon E; Almond, Glen W; Riviere, Jim E; Baynes, Ronald E

2012-10-01

To model the plasma tetracycline concentrations in swine (Sus scrofa domestica) treated with medication administered in water and determine the factors that contribute to the most accurate predictions of measured plasma drug concentrations. Plasma tetracycline concentrations measured in blood samples from 3 populations of swine. Data from previous studies provided plasma tetracycline concentrations that were measured in blood samples collected from 1 swine population at 0, 4, 8, 12, 24, 32, 48, 56, 72, 80, 96, and 104 hours and from 2 swine populations at 0, 12, 24, 48, and 72 hours hours during administration of tetracycline hydrochloride dissolved in water. A 1-compartment pharmacostatistical model was used to analyze 5 potential covariate schemes and determine factors most important in predicting the plasma concentrations of tetracycline in swine. 2 models most accurately predicted the tetracycline plasma concentrations in the 3 populations of swine. Factors of importance were body weight or age of pig, ambient temperature, concentration of tetracycline in water, and water use per unit of time. The factors found to be of importance, combined with knowledge of the individual pharmacokinetic and chemical properties of medications currently approved for administration in water, may be useful in more prudent administration of approved medications administered to swine. Factors found to be important in pharmacostatistical models may allow prediction of plasma concentrations of tetracycline or other commonly used medications administered in water. The ability to predict in vivo concentrations of medication in a population of food animals can be combined with bacterial minimum inhibitory concentrations to decrease the risk of developing antimicrobial resistance.

Generation of high charge state metal ion beams by electron cyclotron resonance heating of vacuum arc plasma in cusp trap.

PubMed

Nikolaev, A G; Savkin, K P; Oks, E M; Vizir, A V; Yushkov, G Yu; Vodopyanov, A V; Izotov, I V; Mansfeld, D A

2012-02-01

A method for generating high charge state heavy metal ion beams based on high power microwave heating of vacuum arc plasma confined in a magnetic trap under electron cyclotron resonance conditions has been developed. A feature of the work described here is the use of a cusp magnetic field with inherent "minimum-B" structure as the confinement geometry, as opposed to a simple mirror device as we have reported on previously. The cusp configuration has been successfully used for microwave heating of gas discharge plasma and extraction from the plasma of highly charged, high current, gaseous ion beams. Now we use the trap for heavy metal ion beam generation. Two different approaches were used for injecting the vacuum arc metal plasma into the trap--axial injection from a miniature arc source located on-axis near the microwave window, and radial injection from sources mounted radially at the midplane of the trap. Here, we describe preliminary results of heating vacuum arc plasma in a cusp magnetic trap by pulsed (400 μs) high power (up to 100 kW) microwave radiation at 37.5 GHz for the generation of highly charged heavy metal ion beams.

Alfvén Waves Generated by Expanding Plasmas in the Laboratory and in Space

NASA Astrophysics Data System (ADS)

Gekelman, W.; Vanzeeland, M.; Vincena, S.; Pribyl, P.

2002-12-01

There are many situations, which occur in space (coronal mass ejections, supernovas), or are man-made (upper atmospheric detonations) in which a dense plasma expands into a background magnetized plasma, that can support Alfvén waves. The LArge Plasma Device (LAPD) is a machine, at UCLA, in which Alfvén waves propagation in homogeneous and inhomogeneous plasmas has been studied. These will be briefly reviewed. Then a new class of experiments which involve the expansion of a dense (initially, n/no>>1) laser-produced plasma into an ambient highly magnetized background plasma capable of supporting Alfvén waves will be presented. The 150 MW laser is pulsed at the same 1 Hz repetition rate as the plasma in a highly reproducible experiment. The laser beam impacts a solid target such that the initial plasma burst is directed either along or across the magnetic field. The interaction results in the production of intense shear and compressional Alfvén waves, as well as large density perturbations. The waves propagate away from the target and are observed to become plasma column resonances. The magnetic fields of the waves are obtained with a 3-axis inductive probe. Spatial patterns of the magnetic fields associated with the waves and density perturbations are measured at over {10}4 locations and will be shown in dramatic movies. These are used to estimate the coupling efficiency of the laser energy and kinetic energy of the dense plasma into wave energy. The wave generation mechanism is due to field aligned return currents, which replace fast electrons escaping the initial blast. Work supported by ONR, DOE, and NSF

A model comparing how rapidly transfusion of solvent detergent plasma restores clotting factors versus infusion of albumin-saline.

PubMed

Jilma-Stohlawetz, Petra; Kursten, Friedrich W; Horvath, Michaela; Leitner, Gerda; List, Jana; Marcek, Jana; Quehenberger, Peter; Schwameis, Michael; Bartko, Johann; Jilma, Bernd

2015-12-01

A recent randomized controlled trial demonstrated the bioequivalence between universally applicable and AB0 compatible transfusion plasma in healthy volunteers. There was a limited change in coagulation factor levels and inhibitors before and after plasmapheresis and subsequent plasma transfusion. The aim of this extension trial was to investigate the true capacity of these plasma products to restore baseline levels of coagulation factors and inhibitors after plasma depletion in comparison to haemodilution induced by infusion of albumin solution. Fourteen healthy subjects, who completed both plasma transfusion periods, underwent an additional plasmapheresis (600 mL) followed by an infusion of 1200 mL albumin (3.125%) in a third period. The fibrinogen levels, as well as other clotting factors (FII, FV, FVII and FXI), decreased by 10% after plasmapheresis, and subsequent infusion of albumin solution further aggravated this drop in clotting factors to approximately 20-25%. The clotting factors with a long half-life were not even restored 24 hours after infusion of albumin solution, whereas those with a short half-life were replenished by endogenous synthesis within 24 hours. In contrast, transfusion of either plasma product rapidly restored all clotting parameters and inhibitors (protein S and plasmin inhibitor) immediately after transfusion. This study demonstrates that albumin solution induces an enhanced dilution of clotting factors and inhibitors, whereas both plasma products quickly compensated for the experimental loss of these plasma proteins. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Synergistic effect of electrical and chemical factors on endocytosis in micro-discharge plasma gene transfection

NASA Astrophysics Data System (ADS)

Jinno, M.; Ikeda, Y.; Motomura, H.; Isozaki, Y.; Kido, Y.; Satoh, S.

2017-06-01

We have developed a new micro-discharge plasma (MDP)-based gene transfection method, which transfers genes into cells with high efficiency and low cytotoxicity; however, the mechanism underlying the method is still unknown. Studies revealed that the N-acetylcysteine-mediated inhibition of reactive oxygen species (ROS) activity completely abolished gene transfer. In this study, we used laser-produced plasma to demonstrate that gene transfer does not occur in the absence of electrical factors. Our results show that both electrical and chemical factors are necessary for gene transfer inside cells by microplasma irradiation. This indicates that plasma-mediated gene transfection utilizes the synergy between electrical and chemical factors. The electric field threshold required for transfection was approximately 1 kV m-1 in our MDP system. This indicates that MDP irradiation supplies sufficient concentrations of ROS, and the stimulation intensity of the electric field determines the transfection efficiency in our system. Gene transfer by plasma irradiation depends mainly on endocytosis, which accounts for at least 80% of the transfer, and clathrin-mediated endocytosis is a dominant endocytosis. In plasma-mediated gene transfection, alterations in electrical and chemical factors can independently regulate plasmid DNA adhesion and triggering of endocytosis, respectively. This implies that plasma characteristics can be adjusted according to target cell requirements, and the transfection process can be optimized with minimum damage to cells and maximum efficiency. This may explain how MDP simultaneously achieves high transfection efficiency with minimal cell damage.

Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.

PubMed

Slatter, David A; Percy, Charles L; Allen-Redpath, Keith; Gajsiewicz, Joshua M; Brooks, Nick J; Clayton, Aled; Tyrrell, Victoria J; Rosas, Marcela; Lauder, Sarah N; Watson, Andrew; Dul, Maria; Garcia-Diaz, Yoel; Aldrovandi, Maceler; Heurich, Meike; Hall, Judith; Morrissey, James H; Lacroix-Desmazes, Sebastien; Delignat, Sandrine; Jenkins, P Vincent; Collins, Peter W; O'Donnell, Valerie B

2018-03-22

Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell-derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic acid-phospholipids (HETE-PLs) restore hemostasis in human and murine conditions of pathological bleeding. HETE-PLs abolished blood loss in murine hemophilia A and enhanced coagulation in factor VIII- (FVIII-), FIX-, and FX-deficient human plasma . HETE-PLs were decreased in platelets from patients after cardiopulmonary bypass (CPB). To explore molecular mechanisms, the ability of eoxPL to stimulate individual isolated coagulation factor/cofactor complexes was tested in vitro. Extrinsic tenase (FVIIa/tissue factor [TF]), intrinsic tenase (FVIIIa/FIXa), and prothrombinase (FVa/FXa) all were enhanced by both HETE-PEs and HETE-PCs, suggesting a common mechanism involving the fatty acid moiety. In plasma, 9-, 15-, and 12-HETE-PLs were more effective than 5-, 11-, or 8-HETE-PLs, indicating positional isomer specificity. Coagulation was enhanced at lower lipid/factor ratios, consistent with a more concentrated area for protein binding. Surface plasmon resonance confirmed binding of FII and FX to HETE-PEs. HETE-PEs increased membrane curvature and thickness, but not surface charge or homogeneity, possibly suggesting increased accessibility to cations/factors. In summary, innate immune-derived eoxPL enhance calcium-dependent coagulation factor function, and their potential utility in bleeding disorders is proposed.

Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies

PubMed Central

Slatter, David A.; Percy, Charles L.; Allen-Redpath, Keith; Gajsiewicz, Joshua M.; Brooks, Nick J.; Tyrrell, Victoria J.; Lauder, Sarah N.; Watson, Andrew; Dul, Maria; Garcia-Diaz, Yoel; Aldrovandi, Maceler; Heurich, Meike; Hall, Judith; Lacroix-Desmazes, Sebastien; Delignat, Sandrine; Jenkins, P. Vincent; Collins, Peter W.; O’Donnell, Valerie B.

2018-01-01

Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell–derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic acid–phospholipids (HETE-PLs) restore hemostasis in human and murine conditions of pathological bleeding. HETE-PLs abolished blood loss in murine hemophilia A and enhanced coagulation in factor VIII- (FVIII-), FIX-, and FX-deficient human plasma . HETE-PLs were decreased in platelets from patients after cardiopulmonary bypass (CPB). To explore molecular mechanisms, the ability of eoxPL to stimulate individual isolated coagulation factor/cofactor complexes was tested in vitro. Extrinsic tenase (FVIIa/tissue factor [TF]), intrinsic tenase (FVIIIa/FIXa), and prothrombinase (FVa/FXa) all were enhanced by both HETE-PEs and HETE-PCs, suggesting a common mechanism involving the fatty acid moiety. In plasma, 9-, 15-, and 12-HETE-PLs were more effective than 5-, 11-, or 8-HETE-PLs, indicating positional isomer specificity. Coagulation was enhanced at lower lipid/factor ratios, consistent with a more concentrated area for protein binding. Surface plasmon resonance confirmed binding of FII and FX to HETE-PEs. HETE-PEs increased membrane curvature and thickness, but not surface charge or homogeneity, possibly suggesting increased accessibility to cations/factors. In summary, innate immune-derived eoxPL enhance calcium-dependent coagulation factor function, and their potential utility in bleeding disorders is proposed. PMID:29563336

Non-thermal atmospheric pressure HF plasma source: generation of nitric oxide and ozone for bio-medical applications

NASA Astrophysics Data System (ADS)

Kühn, S.; Bibinov, N.; Gesche, R.; Awakowicz, P.

2010-01-01

A new miniature high-frequency (HF) plasma source intended for bio-medical applications is studied using nitrogen/oxygen mixture at atmospheric pressure. This plasma source can be used as an element of a plasma source array for applications in dermatology and surgery. Nitric oxide and ozone which are produced in this plasma source are well-known agents for proliferation of the cells, inhalation therapy for newborn infants, disinfection of wounds and blood ozonation. Using optical emission spectroscopy, microphotography and numerical simulation, the gas temperature in the active plasma region and plasma parameters (electron density and electron distribution function) are determined for varied nitrogen/oxygen flows. The influence of the gas flows on the plasma conditions is studied. Ozone and nitric oxide concentrations in the effluent of the plasma source are measured using absorption spectroscopy and electro-chemical NO-detector at variable gas flows. Correlations between plasma parameters and concentrations of the particles in the effluent of the plasma source are discussed. By varying the gas flows, the HF plasma source can be optimized for nitric oxide or ozone production. Maximum concentrations of 2750 ppm and 400 ppm of NO and O3, correspondingly, are generated.

The interaction of intense, ultra-short microwave beams with the plasma generated by gas ionization

NASA Astrophysics Data System (ADS)

Shafir, G.; Cao, Y.; Bliokh, Y.; Leopold, J. G.; Levko, D.; Rostov, V.; Gad, R.; Fisher, A.; Bernshtam, V.; Krasik, Ya. E.

2018-03-01

Results of the non-linear interaction of an extremely short (0.6 ns) high power (˜500 MW) X-band focused microwave beam with the plasma generated by gas ionization are presented. Within certain gas pressure ranges, specific to the gas type, the plasma density is considerably lower around the microwave beam axis than at its periphery, thus forming guiding channel through which the beam self-focuses. Outside these pressure ranges, either diffuse or streamer-like plasma is observed. We also observe high energy electrons (˜15 keV), accelerated by the very high-power microwaves. A simplified analytical model of this complicated dynamical system and particle-in-cell numerical simulations confirm the experimental results.

High Speed and High Functional Inverter Power Supplies for Plasma Generation and Control, and their Performance

NASA Astrophysics Data System (ADS)

Uesugi, Yoshihiko; Razzak, Mohammad A.; Kondo, Kenji; Kikuchi, Yusuke; Takamura, Shuichi; Imai, Takahiro; Toyoda, Mitsuhiro

The Rapid development of high power and high speed semiconductor switching devices has led to their various applications in related plasma fields. Especially, a high speed inverter power supply can be used as an RF power source instead of conventional linear amplifiers and a power supply to control the magnetic field in a fusion plasma device. In this paper, RF thermal plasma production and plasma heating experiments are described emphasis placed on using a static induction transistor inverter at a frequency range between 200 kHz and 2.5 MHz as an RF power supply. Efficient thermal plasma production is achieved experimentally by using a flexible and easily operated high power semiconductor inverter power supply. Insulated gate bipolar transistor (IGBT) inverter power supplies driven by a high speed digital signal processor are applied as tokamak joule coil and vertical coil power supplies to control plasma current waveform and plasma equilibrium. Output characteristics, such as the arbitrary bipolar waveform generation of a pulse width modulation (PWM) inverter using digital signal processor (DSP) can be successfully applied to tokamak power supplies for flexible plasma current operation and fast position control of a small tokamak.

Effect of plasma-rich in platelet-derived growth factors on peri-implant bone healing: An experimental study in canines

PubMed Central

Birang, Reza; Torabi, Alireza; Shahabooei, Mohammad; Rismanchian, Mansour

2012-01-01

Background: Tissue engineering principles can be exploited to enhance alveolar and peri-implant bone reconstruction by applying such biological factors as platelet-derived growth factors. The objective of the present study is to investigate the effect of autologous plasma-rich in growth factors (on the healing of peri-implant bone in canine mandible). Materials and Methods: In this prospective experimental animal study, two healthy canines of the Iranian mix breed were selected. Three months after removing their premolar teeth on both sides of the mandible, 12 implants of the Osteo Implant Corporationsystem, 5 mm in diameter and 10 mm in length, were selected to be implanted. Plasma rich in growth factors (PRGF) were applied on six implants while the other six were used as plain implants without the plasma. The implants were installed in osteotomy sites on both sides of the mandible to be removed after 4 weeks with the surrounding bones using a trephine bur. Mesio-distal sections and implant blocks, 50 μ in diameter containing the peri-implant bone, were prepared By basic fuchin toluidine-bluefor histological and histomorphometric evaluation by optical microscope. The data were analyzed using Mann-Whitney Test (P<0.05). Results: The bone trabeculae and the type of bone generation in PRGF and control groups had no statistically significant differences (P=0.261, P=0.2) although the parameters showed higher measured values in the PRGF group. However, compared to the control, application of PRGF had significantly increased bone-to-implant contact (P=0.028) Conclusion: Based on the results, it may be concluded that application of PRGF on the surface of implant may enhance bone-to-implant contact. PMID:22363370

Sequential plasma angiogenic factors levels in women with suspected preeclampsia.

PubMed

Baltajian, Kedak; Bajracharya, Surichhya; Salahuddin, Saira; Berg, Anders H; Geahchan, Carl; Wenger, Julia B; Thadhani, Ravi; Karumanchi, S Ananth; Rana, Sarosh

2016-07-01

Alterations in circulating angiogenic factors are associated with the diagnosis of preeclampsia and correlate with adverse perinatal outcomes during the third trimester. Analysis of the sequential levels of plasma angiogenic factors among patients admitted for evaluation of preeclampsia. We performed an observational study among women with singleton pregnancies admitted to Beth Israel Deaconess Medical Center, Boston, Massachusetts, for evaluation of preeclampsia at less than 37 weeks of gestation. Plasma samples were collected on admission and daily for the first 3 days and then weekly until delivery. Doppler ultrasound was performed on admission (within 48 hours) and then weekly (within 24 hours of blood collection) to evaluate uteroplacental and umbilical blood flows. Maternal demographics, hospital course, mode of delivery, diagnosis of hypertensive disorder, adverse maternal outcomes (elevated liver function enzymes, low platelet count, pulmonary edema, cerebral hemorrhage, convulsion, acute renal insufficiency, or maternal death), and adverse fetal/neonatal outcomes (small for gestational age, abnormal umbilical artery Doppler, fetal death, and neonatal death) were recorded. Circulating angiogenic factors (soluble fms-like tyrosine kinase and placental growth factor were measured on automated platform in a single batch after delivery and in a blinded fashion. Data are presented as median (25th to 75th centile), mean, or proportions as appropriate. During the study period, data from 100 women were analyzed for the study, and 43 had adverse outcomes. Women with adverse outcomes had lower gestational age of delivery, higher systolic and diastolic blood pressures during hospitalization, and lower birthweight and placental weight (all P < .01). These patients had higher soluble fms-like tyrosine kinase and soluble fms-like tyrosine kinase/placental growth factor ratio on admission and continued to have an increase in levels throughout hospital course. The median

Generation of strongly coupled plasmas by high power excimer laser

NASA Astrophysics Data System (ADS)

Zhu, Yongxiang; Liu, Jingru; Zhang, Yongsheng; Hu, Yun; Zhang, Jiyan; Zheng, Zhijian; Ye, Xisheng

2013-05-01

(ultraviolet). To generate strongly coupled plasmas (SCP) by high power excimer laser, an Au-CH-Al-CH target is used to make the Al sample reach the state of SCP, in which the Au layer transforms laser energy to X-ray that heating the sample by volume and the CH layers provides necessary constraints. With aid of the MULTI-1D code, we calculate the state of the Al sample and its relationship with peak intensity, width and wavelength of laser pulses. The calculated results suggest that an excimer laser with peak intensity of the magnitude of 1013W/cm2 and pulse width being 5ns - 10ns is suitable to generate SCP with the temperature being tens of eV and the density of electron being of the order of 1022/cm-3. Lasers with shorter wavelength, such as KrF laser, are preferable.

Effect of Ti-Al cathode composition on plasma generation and plasma transport in direct current vacuum arc

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhirkov, I., E-mail: igozh@ifm.liu.se; Petruhins, A.; Dahlqvist, M.

2014-03-28

DC arc plasma from Ti, Al, and Ti{sub 1-x}Al{sub x} (x = 0.16, 0.25, 0.50, and 0.70) compound cathodes was characterized with respect to plasma chemistry and charge-state-resolved ion energy. Scanning electron microscopy, X-ray diffraction, and Energy-dispersive X-ray spectroscopy of the deposited films and the cathode surfaces were used for exploring the correlation between cathode-, plasma-, and film composition. Experimental work was performed at a base pressure of 10{sup −6} Torr, to exclude plasma-gas interaction. The plasma ion composition showed a reduction of Al of approximately 5 at. % compared to the cathode composition, while deposited films were in accordance with the cathodemore » stoichiometry. This may be explained by presence of neutrals in the plasma/vapour phase. The average ion charge states (Ti = 2.2, Al = 1.65) were consistent with reference data for elemental cathodes, and approximately independent on the cathode composition. On the contrary, the width of the ion energy distributions (IEDs) were drastically reduced when comparing the elemental Ti and Al cathodes with Ti{sub 0.5}Al{sub 0.5}, going from ∼150 and ∼175 eV to ∼100 and ∼75 eV for Ti and Al ions, respectively. This may be explained by a reduction in electron temperature, commonly associated with the high energy tail of the IED. The average Ti and Al ion energies ranged between ∼50 and ∼61 eV, and ∼30 and ∼50 eV, respectively, for different cathode compositions. The attained energy trends were explained by the velocity rule for compound cathodes, which states that the most likely velocities of ions of different mass are equal. Hence, compared to elemental cathodes, the faster Al ions will be decelerated, and the slower Ti ions will be accelerated when originating from compound cathodes. The intensity of the macroparticle generation and thickness of the deposited films were also found to be dependent on the cathode composition. The presented

Marginal Emissions Factors for Electricity Generation in the Midcontinent ISO.

PubMed

Thind, Maninder P S; Wilson, Elizabeth J; Azevedo, Inês L; Marshall, Julian D

2017-12-19

Environmental consequences of electricity generation are often determined using average emission factors. However, as different interventions are incrementally pursued in electricity systems, the resulting marginal change in emissions may differ from what one would predict based on system-average conditions. Here, we estimate average emission factors and marginal emission factors for CO 2 , SO 2 , and NO x from fossil and nonfossil generators in the Midcontinent Independent System Operator (MISO) region during years 2007-2016. We analyze multiple spatial scales (all MISO; each of the 11 MISO states; each utility; each generator) and use MISO data to characterize differences between the two emission factors (average; marginal). We also explore temporal trends in emissions factors by hour, day, month, and year, as well as the differences that arise from including only fossil generators versus total generation. We find, for example, that marginal emission factors are generally higher during late-night and early morning compared to afternoons. Overall, in MISO, average emission factors are generally higher than marginal estimates (typical difference: ∼20%). This means that the true environmental benefit of an energy efficiency program may be ∼20% smaller than anticipated if one were to use average emissions factors. Our analysis can usefully be extended to other regions to support effective near-term technical, policy and investment decisions based on marginal rather than only average emission factors.

Generating Long Scale-Length Plasma Jets Embedded in a Uniform, Multi-Tesla Magnetic-Field

NASA Astrophysics Data System (ADS)

Manuel, Mario; Kuranz, Carolyn; Rasmus, Alex; Klein, Sallee; Fein, Jeff; Belancourt, Patrick; Drake, R. P.; Pollock, Brad; Hazi, Andrew; Park, Jaebum; Williams, Jackson; Chen, Hui

2013-10-01

Collimated plasma jets emerge in many classes of astrophysical objects and are of great interest to explore in the laboratory. In many cases, these astrophysical jets exist within a background magnetic field where the magnetic pressure approaches the plasma pressure. Recent experiments performed at the Jupiter Laser Facility utilized a custom-designed solenoid to generate the multi-tesla fields necessary to achieve proper magnetization of the plasma. Time-gated interferometry, Schlieren imaging, and proton radiography were used to characterize jet evolution and collimation under varying degrees of magnetization. Experimental results will be presented and discussed. This work is funded by the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, grant number DE-NA0001840, by the National Laser User Facility Program, grant number DE-NA0000850, by the Predictive Sciences Academic Alliances Program in NNSA-ASC, grant number DEFC52-08NA28616, and by NASA through Einstein Postdoctoral Fellowship grant number PF3-140111 awarded by the Chandra X-ray Center, which is operated by the Smithsonian Astrophysical Observatory for NASA under contract NAS8-03060.

Plasma pharmacy - physical plasma in pharmaceutical applications.

PubMed

von Woedtke, Th; Haertel, B; Weltmann, K-D; Lindequist, U

2013-07-01

During the last years the use of physical plasma for medical applications has grown rapidly. A multitude of findings about plasma-cell and plasma-tissue interactions and its possible use in therapy have been provided. One of the key findings of plasma medical basic research is that several biological effects do not result from direct plasma-cell or plasma-tissue interaction but are mediated by liquids. Above all, it was demonstrated that simple liquids like water or physiological saline, are antimicrobially active after treatment by atmospheric pressure plasma and that these effects are attributable to the generation of different low-molecular reactive species. Besides, it could be shown that plasma treatment leads to the stimulation of specific aspects of cell metabolism and to a transient and reversible increase of diffusion properties of biological barriers. All these results gave rise to think about another new and innovative field of medical plasma application. In contrast to plasma medicine, which means the direct use of plasmas on or in the living organism for direct therapeutic purposes, this field - as a specific field of medical plasma application - is called plasma pharmacy. Based on the present state of knowledge, most promising application fields of plasma pharmacy might be: plasma-based generation of biologically active liquids; plasma-based preparation, optimization, or stabilization of - mainly liquid - pharmaceutical preparations; support of drug transport across biological barriers; plasma-based stimulation of biotechnological processes.

Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation.

PubMed

van der Meijden, Paola E J; Feijge, Marion A H; Swieringa, Frauke; Gilio, Karen; Nergiz-Unal, Reyhan; Hamulyák, Karly; Heemskerk, Johan W M

2012-10-01

The fibrin(ogen) receptor, integrin α(IIb)β(3), has a well-established role in platelet spreading, aggregation and clot retraction. How α(IIb)β(3) contributes to platelet-dependent coagulation is less well resolved. Here, we demonstrate that the potent suppressing effect of clinically used α(IIb)β(3) blockers on tissue factor-induced thrombin generation is linked to diminished platelet Ca(2+) responses and phosphatidylserine (PS) exposure. The same blockers suppress these responses in platelets stimulated with collagen and thrombin receptor agonists, whereas added fibrinogen potentiates these responses. In platelets spreading on fibrinogen, outside-in α(IIb)β(3) signaling similarly enhances thrombin-induced Ca(2+) rises and PS exposure. These responses are reduced in α(IIb)β(3)-deficient platelets from patients with Glanzmann's thrombasthenia. Furthermore, the contribution of α(IIb)β(3) to tissue factor-induced platelet Ca(2+) rises, PS exposure and thrombin generation in plasma are fully dependent on Syk kinase activity. Tyrosine phosphorylation analysis confirms a key role of Syk activation, which is largely but not exclusively dependent on α(IIb)β(3) activation. It is concluded that the majority of tissue factor-induced procoagulant activity of platelets relies on Syk activation and ensuing Ca(2+) signal generation, and furthermore that a considerable part of Syk activation relies on α(IIb)β(3) signaling. These results hence point to a novel role of Syk in integrin-dependent thrombin generation.

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone.

PubMed

Rivera, César; Monsalve, Francisco; Salas, Juan; Morán, Andrea; Suazo, Iván

2013-12-01

Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of treatment with either platelet-rich plasma (PRP) or plasma rich in growth factors (PRGF) in combination with SIMV in the regeneration and repair of alveolar bone. The jaws of Sprague Dawley rats (n=18) were subjected to rotary instrument-induced bone damage (BD). Animals were divided into six groups: BD/H 2 O (n=3), distilled water without the drug and alveolar bone damage; BD/H 2 O/PRP (n=3), BD and PRP; BD/H 2 O/PRGF (n=3), BD and PRGF; BD/SIMV (n=3), BD and water with SIMV; BD/SIMV/PRP (n=3), BD, PRP and SIMV; and BD/SIMV/PRGF (n=3), BD, PRGF and SIMV. Conventional histological analysis (hematoxylin and eosin staining) revealed that the BD/SIMV group showed indicators for mature bone tissue, while the BD/SIMV/PRP and BD/SIMV/PRGF groups showed the coexistence of indicators for mature and immature bone tissue, with no statistical differences between the platelet preparations. Simvastatin did not improve the effect of platelet-rich plasma and plasma rich in growth factors. It was not possible to determine which platelet preparation produced superior effects.

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone

PubMed Central

RIVERA, CÉSAR; MONSALVE, FRANCISCO; SALAS, JUAN; MORÁN, ANDREA; SUAZO, IVÁN

2013-01-01

Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of treatment with either platelet-rich plasma (PRP) or plasma rich in growth factors (PRGF) in combination with SIMV in the regeneration and repair of alveolar bone. The jaws of Sprague Dawley rats (n=18) were subjected to rotary instrument-induced bone damage (BD). Animals were divided into six groups: BD/H2O (n=3), distilled water without the drug and alveolar bone damage; BD/H2O/PRP (n=3), BD and PRP; BD/H2O/PRGF (n=3), BD and PRGF; BD/SIMV (n=3), BD and water with SIMV; BD/SIMV/PRP (n=3), BD, PRP and SIMV; and BD/SIMV/PRGF (n=3), BD, PRGF and SIMV. Conventional histological analysis (hematoxylin and eosin staining) revealed that the BD/SIMV group showed indicators for mature bone tissue, while the BD/SIMV/PRP and BD/SIMV/PRGF groups showed the coexistence of indicators for mature and immature bone tissue, with no statistical differences between the platelet preparations. Simvastatin did not improve the effect of platelet-rich plasma and plasma rich in growth factors. It was not possible to determine which platelet preparation produced superior effects. PMID:24250728

Contact Activation of Blood Plasma and Factor XII by Ion-exchange Resins

PubMed Central

Yeh, Chyi-Huey Josh; Dimachkie, Ziad O.; Golas, Avantika; Cheng, Alice; Parhi, Purnendu; Vogler, Erwin A.

2011-01-01

Sepharose ion-exchange particles bearing strong Lewis acid/base functional groups (sulfopropyl, carboxymethyl, quarternary ammonium, dimethyl aminoethyl, and iminodiacetic acid) exhibiting high plasma protein adsorbent capacities are shown to be more efficient activators of blood factor XII in neat-buffer solution than either hydrophilic clean-glass particles or hydrophobic octyl sepharose particles ( FXII→surfaceactivatorFXIIa; a.k.a autoactivation, where FXII is the zymogen and FXIIa is a procoagulant protease). In sharp contrast to the clean-glass standard of comparison, ion-exchange activators are shown to be inefficient activators of blood plasma coagulation. These contrasting activation properties are proposed to be due to the moderating effect of plasma-protein adsorption on plasma coagulation. Efficient adsorption of blood plasma proteins unrelated to the coagulation cascade impedes FXII contacts with ion-exchange particles immersed in plasma, reducing autoactivation, and causing sluggish plasma coagulation. By contrast, plasma proteins do not adsorb to hydrophilic clean glass and efficient autoactivation leads directly to efficient activation of plasma coagulation. It is also shown that competitive-protein adsorption can displace FXIIa adsorbed to the surface of ion-exchange resins. As a consequence of highly-efficient autoactivation and FXIIa displacement by plasma proteins, ion-exchange particles are slightly more efficient activators of plasma coagulation than hydrophobic octyl sepharose particles that do not bear strong Lewis acid/base surface functionalities but to which plasma proteins adsorb efficiently. Plasma proteins thus play a dual role in moderating contact activation of the plasma coagulation cascade. The principal role is impeding FXII contact with activating surfaces but this same effect can displace FXIIa from an activating surface into solution where the protease can potentiate subsequent steps of the plasma coagulation cascade. PMID

Analytical and between-subject variation of thrombin generation measured by calibrated automated thrombography on plasma samples.

PubMed

Kristensen, Anne F; Kristensen, Søren R; Falkmer, Ursula; Münster, Anna-Marie B; Pedersen, Shona

2018-05-01

The Calibrated Automated Thrombography (CAT) is an in vitro thrombin generation (TG) assay that holds promise as a valuable tool within clinical diagnostics. However, the technique has a considerable analytical variation, and we therefore, investigated the analytical and between-subject variation of CAT systematically. Moreover, we assess the application of an internal standard for normalization to diminish variation. 20 healthy volunteers donated one blood sample which was subsequently centrifuged, aliquoted and stored at -80 °C prior to analysis. The analytical variation was determined on eight runs, where plasma from the same seven volunteers was processed in triplicates, and for the between-subject variation, TG analysis was performed on plasma from all 20 volunteers. The trigger reagents used for the TG assays included both PPP reagent containing 5 pM tissue factor (TF) and PPPlow with 1 pM TF. Plasma, drawn from a single donor, was applied to all plates as an internal standard for each TG analysis, which subsequently was used for normalization. The total analytical variation for TG analysis performed with PPPlow reagent is 3-14% and 9-13% for PPP reagent. This variation can be minimally reduced by using an internal standard but mainly for ETP (endogenous thrombin potential). The between-subject variation is higher when using PPPlow than PPP and this variation is considerable higher than the analytical variation. TG has a rather high inherent analytical variation but considerable lower than the between-subject variation when using PPPlow as reagent.

Partially ionized plasmas including the third symposium on uranium plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krishnan, M.

1976-09-01

Separate abstracts are included for 28 papers on electrically generated plasmas, fission generated plasmas, nuclear pumped lasers, gaseous fuel reactor research, and applications. Five papers have been previously abstracted and included in ERA.

Generation and remote delivery of plasma activated species

NASA Astrophysics Data System (ADS)

Maguire, Paul; Mahony, Charles; Kelsey, Colin; Rutherford, David; Mariotti, Davide; Macias-Montero, Manuel; Perez-Martin, Fatima; Diver, Declan

2016-09-01

Plasma interactions with microdroplets offer new opportunities to deliver active chemical agents and nanoparticles to remote substrates downstream with many potential applications from cancer theranostics and wound healing in biomedicine, gentle food decontamination and seed germination in plasma agriculture to catalyst production and photonic structures fabrication, among others. We demonstrate plasma-liquid based pristine nanomaterials synthesis in flight and subsequent delivery up to 120mm from the atmospheric pressure plasma source. Monosized and non-aggregating metal nanoparticles are formed in the rf plasma in less than 100us, representing an increase in precursor reduction rate that is many (>4) orders of magnitude faster than that observed with standard colloidal chemistry or via high energy radiolytic techniques. Also the collection and purification limitations of the latter are avoided. Plasma activated liquid including OH radicals and H2O2 are transported over 120mm and have demonstrated high efficacy bacterial decontamination. These results will be compared with charge species and radical transport from the rf plasma without microdroplets. Reaction models based on high solvated surface electron concentrations will be presented. Funding from EPSRC acknowledged (Grants EP/K006088/1 and EP/K006142/1).

Nonthermal model for ultrafast laser-induced plasma generation around a plasmonic nanorod

NASA Astrophysics Data System (ADS)

Labouret, Timothée; Palpant, Bruno

2016-12-01

The excitation of plasmonic gold nanoparticles by ultrashort laser pulses can trigger interesting electron-based effects in biological media such as production of reactive oxygen species or cell membrane optoporation. In order to better understand the optical and thermal processes at play, we modeled the interaction of a subpicosecond, near-infrared laser pulse with a gold nanorod in water. A nonthermal model is used and compared to a simple two-temperature thermal approach. For both models, the computation of the transient optical response reveals strong plasmon damping. Electron emission from the metal into the water is also calculated in a specific way for each model. The dynamics of the resulting local plasma in water is assessed by a rate equation model. While both approaches provide similar results for the transient optical properties, the simple thermal one is unable to properly describe electron emission and plasma generation. The latter is shown to mostly originate from electron-electron thermionic emission and photoemission from the metal. Taking into account the transient optical response is mandatory to properly calculate both electron emission and local plasma dynamics in water.

Plasma precipitation on Mercury's nightside and its implications for magnetospheric convection and exosphere generation.

NASA Astrophysics Data System (ADS)

Raines, J. M.; Slavin, J. A.; Tracy, P.; Gershman, D. J.; Zurbuchen, T.; Korth, H.; Anderson, B. J.; Solomon, S. C.

2015-12-01

Plasma impact onto Mercury's surface can be an important contributor to Mercury's exosphere through the process of ion sputtering. Under some circumstances, this process can produce a substantial fraction of the exosphere. When the impacting plasma originates from the magnetosphere itself, this sputtering process can conversely be considered as a sink for the plasma of the Mercury magnetosphere, providing evidence for the processes at work in that system. One such process is reconnection in Mercury's magnetotail, which can accelerate ions and electrons from the central plasma sheet toward the nightside of the planet. By analogy with processes at Earth, it is hypothesized that as these flows approach the planet, much of the plasma is diverted from impact onto the surface by the increasingly strong planetary magnetic field closer to the planet. The remainder of the plasma is expected to follow nearly dipolar field lines, impacting the nightside surface and potentially contributing to field-aligned currents. We present the first direct evidence that this process is operating at Mercury. We examine ion precipitation events on Mercury's nightside with the Fast Imaging Plasma Spectrometer (FIPS) on the MESSENGER spacecraft, which orbited Mercury from 2011 to 2015. We characterize the energy distributions of these events and their extent in latitude and local time. We use these observations to predict the precipitating proton flux from altitudes as low as 11 km. We use this information to bound the region of Mercury's surface that remains protected from plasma bombardment by the planetary dipole magnetic field, and to explore the implications of this information for magnetospheric convection and exosphere generation at Mercury.

Plasma precipitation on Mercury's nightside and its implications for magnetospheric convection and exosphere generation.

NASA Astrophysics Data System (ADS)