SEMICIRCULAR-LIKE SECONDARY FLARE RIBBONS ASSOCIATED WITH A FAILED ERUPTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, R.; Korsós, M. B.; Erdélyi, R., E-mail: r.zheng@sheffield.ac.uk, E-mail: robertus@sheffield.ac.uk

Flare ribbons (FRs) are one of the most apparent signatures of solar flares and have been treated as an indicator of magnetic reconnection. Drawing upon the observations from the Solar Dynamics Observatory, we present semicircular-like secondary FRs (SFRs) of a C2.3 flare on 2013 June 19. Before the flare eruption, two bipoles in this core region subsequently emerged. Due to the interaction between the two bipoles, a tether-cutting eruption took place in the core region. The SFRs, surrounding the core region nearly simultaneously with the flare onset, were much weaker than the two normal FRs. Two ends of the SFRsmore » experienced a separation and extension movement, but the middle part of the SFRs hardly expanded outward. We find SFRs are closely associated with the footpoint brightenings of some small loops around the core region. The eruption was confined by transequatorial loops (TLs), which resulted in the plasma material falling in the north end of the TLs and remote brightenings showing up in the south end of the TLs. The disappearance of the faint (filament) material during the emergence of the SFRs could indicate another eruption. We conclude that two or more magnetic reconnections are involved in this event and propose that SFRs consisting of a small part of true FRs resulted from the second magnetic reconnection and bright footpoints of loop clusters likely heated by the main flare.« less

Past and future star formation in disk galaxies

NASA Astrophysics Data System (ADS)

Kennicutt, Robert C., Jr.; Tamblyn, Peter; Congdon, Charles E.

1994-11-01

We have combined H-alpha and UBV measurements of 210 nearby Sa-Irr galaxies with new photometric synthesis models to reanalyze the past and future star formation timescales in disks. The integrated photoionization rates and colors of disks are best fitted by a stellar initial mass function (IMF) which is enriched in massive stars by a factor of 2-3 relative to the Scalo solar neighborhood IMF. We have used published surface photometry of spiral galaxies to analyze the star formation histories of disks independent of their bulge properties. The ratio of the current star formation rate (SFR) to the average past rate increases from of order 0.01 in Sa galaxies to 1 in Sc-Irr disks. This confirms that the pronounced change in the photometric properties of spiral galaxies along the Hubble sequence is predominantly due to changes in the star formation histories of disks, and only secondarily to changes in the bulge/disk ratio. A comparison of current SFRs and gas masses of the sample yields median timescales for gas consumption of approximately 3 Gyr, in the absence of stellar recycling. However, a proper time-dependent treatment of the gas return from stars shows that recycling extends the gas lifetimes of disks by factors of 1.5-4 for typical disk parameters. Consequently the current SFRs in many (but not all) disks can be sustained for periods comparable to the Hubble time.

CHARACTERIZING THE STAR FORMATION OF THE LOW-MASS SHIELD GALAXIES FROM HUBBLE SPACE TELESCOPE IMAGING

DOE Office of Scientific and Technical Information (OSTI.GOV)

McQuinn, Kristen B. W.; Skillman, Evan D.; Simones, Jacob E.

The Survey of Hi in Extremely Low-mass Dwarfs is an on-going multi-wavelength program to characterize the gas, star formation, and evolution in gas-rich, very low-mass galaxies that populate the faint end of the galaxy luminosity function. The galaxies were selected from the first ∼10% of the Hi Arecibo Legacy Fast ALFA survey based on their low Hi mass and low baryonic mass. Here, we measure the star formation properties from optically resolved stellar populations for 12 galaxies using a color–magnitude diagram fitting technique. We derive lifetime average star formation rates (SFRs), recent SFRs, stellar masses, and gas fractions. Overall, themore » recent SFRs are comparable to the lifetime SFRs with mean birthrate parameter of 1.4, with a surprisingly narrow standard deviation of 0.7. Two galaxies are classified as dwarf transition galaxies (dTrans). These dTrans systems have star formation and gas properties consistent with the rest of the sample, in agreement with previous results that some dTrans galaxies may simply be low-luminosity dwarf irregulars. We do not find a correlation between the recent star formation activity and the distance to the nearest neighboring galaxy, suggesting that the star formation process is not driven by gravitational interactions, but regulated internally. Further, we find a broadening in the star formation and gas properties (i.e., specific SFRs, stellar masses, and gas fractions) compared to the generally tight correlation found in more massive galaxies. Overall, the star formation and gas properties indicate these very low-mass galaxies host a fluctuating, non-deterministic, and inefficient star formation process.« less

Tests of star formation metrics in the low-metallicity galaxy NGC 5253 using ALMA observations of H30α line emission

NASA Astrophysics Data System (ADS)

Bendo, G. J.; Miura, R. E.; Espada, D.; Nakanishi, K.; Beswick, R. J.; D'Cruze, M. J.; Dickinson, C.; Fuller, G. A.

2017-11-01

We use Atacama Large Millimeter/submillimeter Array (ALMA) observations of H30α (231.90 GHz) emission from the low-metallicity dwarf galaxy NGC 5253 to measure the star formation rate (SFR) within the galaxy and to test the reliability of SFRs derived from other commonly used metrics. The H30α emission, which originates mainly from the central starburst, yields a photoionizing photon production rate of (1.9 ± 0.3) × 1052 s-1 and an SFR of 0.087 ± 0.013 M⊙ yr-1 based on conversions that account for the low metallicity of the galaxy and for stellar rotation. Among the other star formation metrics we examined, the SFR calculated from the total infrared flux was statistically equivalent to the values from the H30α data. The SFR based on a previously published version of the H α flux that was extinction corrected using Paα and Paβ lines was lower than but also statistically similar to the H30α value. The mid-infrared (22 μm) flux density and the composite star formation tracer based on H α and mid-infrared emission give SFRs that were significantly higher because the dust emission appears unusually hot compared to typical spiral galaxies. Conversely, the 70 and 160 μm flux densities yielded SFRs lower than the H30α value, although the SFRs from the 70 μm and H30α data were within 1σ-2σ of each other. While further analysis on a broader range of galaxies is needed, these results are instructive of the best and worst methods to use when measuring SFR in low-metallicity dwarf galaxies like NGC 5253.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mor, Rivay; Netzer, Hagai; Trakhtenbrot, Benny

We report new Herschel observations of 25 z {approx_equal} 4.8 extremely luminous optically selected active galactic nuclei (AGNs). Five of the sources have extremely large star-forming (SF) luminosities, L{sub SF}, corresponding to SF rates (SFRs) of 2800-5600 M{sub Sun} yr{sup -1} assuming a Salpeter initial mass function. The remaining sources have only upper limits on their SFRs, but stacking their Herschel images results in a mean SFR of 700 {+-} 150 M{sub Sun} yr{sup -1}. The higher SFRs in our sample are comparable to the highest observed values so far at any redshift. Our sample does not contain obscured AGNs,more » which enables us to investigate several evolutionary scenarios connecting supermassive black holes and SF activity in the early universe. The most probable scenario is that we are witnessing the peak of SF activity in some sources and the beginning of the post-starburst decline in others. We suggest that all 25 sources, which are at their peak AGN activity, are in large mergers. AGN feedback may be responsible for diminishing the SF activity in 20 of them, but is not operating efficiently in 5 others.« less

Estimating the Star Formation Rate at 1 kpc Scales in nearby Galaxies

NASA Astrophysics Data System (ADS)

Leroy, Adam K.; Bigiel, Frank; de Blok, W. J. G.; Boissier, Samuel; Bolatto, Alberto; Brinks, Elias; Madore, Barry; Munoz-Mateos, Juan-Carlos; Murphy, Eric; Sandstrom, Karin; Schruba, Andreas; Walter, Fabian

2012-07-01

Using combinations of Hα, ultraviolet (UV), and infrared (IR) emission, we estimate the star formation rate (SFR) surface density, ΣSFR, at 1 kpc resolution for 30 disk galaxies that are targets of the IRAM HERACLES CO survey. We present a new physically motivated IR spectral-energy-distribution-based approach to account for possible contributions to 24 μm emission not associated with recent star formation. Considering a variety of "reference" SFRs from the literature, we revisit the calibration of the 24 μm term in hybrid (UV+IR or Hα+IR) tracers. We show that the overall calibration of this term remains uncertain at the factor of two level because of the lack of wide-field, robust reference SFR estimates. Within this uncertainty, published calibrations represent a reasonable starting point for 1 kpc-wide areas of star-forming disk galaxies, but we re-derive and refine the calibration of the IR term in these tracers to match our resolution and approach to 24 μm emission. We compare a large suite of ΣSFR estimates and find that above ΣSFR ~ 10-3 M ⊙ yr-1 kpc-2 the systematic differences among tracers are less than a factor of two across two orders of magnitude dynamic range. We caution that methodology and data both become serious issues below this level. We note from simple model considerations that when focusing on a part of a galaxy dominated by a single stellar population, the intrinsic uncertainty in Hα- and FUV-based SFRs is ~0.3 and ~0.5 dex.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Getman, Konstantin V.; Broos, Patrick S.; Feigelson, Eric D.

The Star Formation in Nearby Clouds (SFiNCs) project is aimed at providing a detailed study of the young stellar populations and of star cluster formation in the nearby 22 star-forming regions (SFRs) for comparison with our earlier MYStIX survey of richer, more distant clusters. As a foundation for the SFiNCs science studies, here, homogeneous data analyses of the Chandra X-ray and Spitzer mid-infrared archival SFiNCs data are described, and the resulting catalogs of over 15,300 X-ray and over 1,630,000 mid-infrared point sources are presented. On the basis of their X-ray/infrared properties and spatial distributions, nearly 8500 point sources have been identifiedmore » as probable young stellar members of the SFiNCs regions. Compared to the existing X-ray/mid-infrared publications, the SFiNCs member list increases the census of YSO members by 6%–200% for individual SFRs and by 40% for the merged sample of all 22 SFiNCs SFRs.« less

Are We Correctly Measuring Star-Formation Rates?

NASA Astrophysics Data System (ADS)

McQuinn, Kristen B.; Skillman, Evan D.; Dolphin, Andrew E.; Mitchell, Noah P.

2017-01-01

Integrating our knowledge of star formation (SF) traced by observations at different wavelengths is essential for correctly interpreting and comparing SF activity in a variety of systems and environments. This study compares extinction-corrected, integrated ultraviolet (UV) emission from resolved galaxies with color-magnitude diagram (CMD) based star-formation rates (SFRs) derived from resolved stellar populations and CMD fitting techniques in 19 nearby starburst and post-starburst dwarf galaxies. The data sets are from the panchromatic Starburst Irregular Dwarf Survey (STARBIRDS) and include deep legacy GALEX UV imaging, Hubble Space Telescope optical imaging, and Spitzer MIPS imaging. For the majority of the sample, the integrated near-UV fluxes predicted from the CMD-based SFRs—using four different models—agree with the measured, extinction corrected, integrated near-UV fluxes from GALEX images, but the far-UV (FUV) predicted fluxes do not. Furthermore, we find a systematic deviation between the SFRs based on integrated FUV luminosities and existing scaling relations, and the SFRs based on the resolved stellar populations. This offset is not driven by different SF timescales, variations in SFRs, UV attenuation, nor stochastic effects. This first comparison between CMD-based SFRs and an integrated FUV emission SFR indicator suggests that the most likely cause of the discrepancy is the theoretical FUV-SFR calibration from stellar evolutionary libraries and/or stellar atmospheric models. We present an empirical calibration of the FUV-based SFR relation for dwarf galaxies, with uncertainties, which is ˜53% larger than previous relations. These results have signficant implications for measuring FUV-based SFRs of high-redshift galaxies.

How dead are dead galaxies? Mid-infrared fluxes of quiescent galaxies at redshift 0.3 < z < 2.5: implications for star formation rates and dust heating

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fumagalli, Mattia; Labbé, Ivo; Patel, Shannon G.

We investigate star formation rates (SFRs) of quiescent galaxies at high redshift (0.3 < z < 2.5) using 3D-HST WFC3 grism spectroscopy and Spitzer mid-infrared data. We select quiescent galaxies on the basis of the widely used UVJ color-color criteria. Spectral energy distribution (SED) fitting (rest-frame optical and near-IR) indicates very low SFRs for quiescent galaxies (sSFR ∼ 10{sup –12} yr{sup –1}). However, SED fitting can miss star formation if it is hidden behind high dust obscuration and ionizing radiation is re-emitted in the mid-infrared. It is therefore fundamental to measure the dust-obscured SFRs with a mid-IR indicator. We stackmore » the MIPS 24 μm images of quiescent objects in five redshift bins centered on z = 0.5, 0.9, 1.2, 1.7, 2.2 and perform aperture photometry. Including direct 24 μm detections, we find sSFR ∼ 10{sup –11.9} × (1 + z){sup 4} yr{sup –1}. These values are higher than those indicated by SED fitting, but at each redshift they are 20-40 times lower than those of typical star-forming galaxies. The true SFRs of quiescent galaxies might be even lower, as we show that the mid-IR fluxes can be due to processes unrelated to ongoing star formation, such as cirrus dust heated by old stellar populations and circumstellar dust. Our measurements show that star formation quenching is very efficient at every redshift. The measured SFR values are at z > 1.5 marginally consistent with the ones expected from gas recycling (assuming that mass loss from evolved stars refuels star formation) and well below that at lower redshifts.« less

13CO Survey of Northern Intermediate-Mass Star-Forming Regions

NASA Astrophysics Data System (ADS)

Lundquist, Michael J.; Kobulnicky, H. A.; Kerton, C. R.

2014-01-01

We conducted a survey of 13CO with the OSO 20-m telescope toward 68 intermediate-mass star-forming regions (IM SFRs) visible in the northern hemisphere. These regions have mostly been excluded from previous CO surveys and were selected from IRAS colors that specify cool dust and large PAH contribution. These regions are known to host stars up to, but not exceeding, about 8 solar masses. We detect 13CO in 57 of the 68 IM SFRs down to a typical RMS of ~50 mK. We present kinematic distances, minimum column densities, and minimum masses for these IM SFRs.

The mean star formation rates of unobscured QSOs: searching for evidence of suppressed or enhanced star formation

NASA Astrophysics Data System (ADS)

Stanley, F.; Alexander, D. M.; Harrison, C. M.; Rosario, D. J.; Wang, L.; Aird, J. A.; Bourne, N.; Dunne, L.; Dye, S.; Eales, S.; Knudsen, K. K.; Michałowski, M. J.; Valiante, E.; De Zotti, G.; Furlanetto, C.; Ivison, R.; Maddox, S.; Smith, M. W. L.

2017-12-01

We investigate the mean star formation rates (SFRs) in the host galaxies of ∼3000 optically selected quasi-stellar objects (QSOs) from the Sloan Digital Sky Survey within the Herschel-ATLAS fields, and a radio-luminous subsample covering the redshift range of z = 0.2-2.5. Using Wide-field Infrared Survey Explorer (WISE) and Herschel photometry (12-500 μm) we construct composite spectral energy distributions (SEDs) in bins of redshift and active galactic nucleus (AGN) luminosity. We perform SED fitting to measure the mean infrared luminosity due to star formation, removing the contamination from AGN emission. We find that the mean SFRs show a weak positive trend with increasing AGN luminosity. However, we demonstrate that the observed trend could be due to an increase in black hole (BH) mass (and a consequent increase of inferred stellar mass) with increasing AGN luminosity. We compare to a sample of X-ray selected AGN and find that the two populations have consistent mean SFRs when matched in AGN luminosity and redshift. On the basis of the available virial BH masses, and the evolving BH mass to stellar mass relationship, we find that the mean SFRs of our QSO sample are consistent with those of main sequence star-forming galaxies. Similarly the radio-luminous QSOs have mean SFRs that are consistent with both the overall QSO sample and with star-forming galaxies on the main sequence. In conclusion, on average QSOs reside on the main sequence of star-forming galaxies, and the observed positive trend between the mean SFRs and AGN luminosity can be attributed to BH mass and redshift dependencies.

Impact of the deployment schedule of fast breeding reactors in the frame of French act for nuclear materials and radioactive waste management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le Mer, J.; Garzenne, C.; Lemasson, D.

In the frame of the French Act of June 28, 2006 on 'a sustainable management of nuclear materials and radioactive waste' EDF R and D assesses various research scenarios of transition between the actual French fleet and a Generation IV fleet with a closed fuel cycle where plutonium is multi-recycled. The basic scenarios simulate a deployment of 60 GWe of Sodium-cooled Fast Reactors (SFRs) in two steps: one third from 2040 to 2050 and the rest from 2080 to 2100 (scenarios 2040). These research scenarios assume that SFR technology will be ready for industrial deployment in 2040. One of themore » many sensitivity analyses that EDF, as a nuclear power plant operator, must evaluate is the impact of a delay of SFR technology in terms of uranium consumptions, plutonium needs and fuel cycle utilities gauging. The sensitivity scenarios use the same assumptions as scenarios 2040 but they simulate a different transition phase: SFRs are deployed in one step between 2080 and 2110 (scenarios 2080). As the French Act states to conduct research on minor actinides (MA) management, we studied different options for 2040 and 2080 scenarios: no MA transmutation, americium transmutation in heterogeneous mode based on americium Bearing Blankets (AmBB) in SFRs and all MA transmutation in heterogeneous mode based on MA Bearing Blankets (MABB). Moreover, we studied multiple parameters that could impact the deployment of these reactors (SFR load factor, increase of the use of MOX in Light Water Reactors, increase of the cooling time in spent nuclear fuel storage...). Each scenario has been computed with the EDF R and D fuel cycle simulation code TIRELIRE-STRATEGIE and optimized to meet various fuel cycle constraints such as using the reprocessing facility with long period of constant capacity, keeping the temporary stored mass of plutonium and MA under imposed limits, recycling older assemblies first... These research scenarios show that the transition from the current PWR fleet to an equivalent fleet of Generation IV SFR can follow different courses. The design of SFR-V2B that we used in our studies needs a high inventory of plutonium resulting in tension on this resource. Several options can be used in order to loosen this tension: our results lead to favour the use of axial breeding blanket in SFR. Load factor of upcoming reactors has to be regarded with attention as it has a high impact on plutonium resource for a given production of electricity. The deployment of SFRs beginning in 2080 instead of 2040 following the scenarios we described creates higher tensions on reprocessing capacity, separated plutonium storage and spent fuel storage. In the frame of the French Act, we studied minor actinides transmutation. The flux of MA in all fuel cycle plants is really high, which will lead to decay heat, a and neutron emission related problems. In terms of reduction of MA inventories, the deployment of MA transmutation cycle must not delay the installation of SFRs. The plutonium production in MABB and AmBB does not allow reducing the use of axial breeding blankets. The impact of MA or Am transmutation over the high level waste disposal is more important if the SFRs are deployed later. Transmutation option (americium or all MA) does not have a significant impact on the number of canister produced nor on its long-term thermal properties. (authors)« less

Spatially unresolved SED fitting can underestimate galaxy masses: a solution to the missing mass problem

NASA Astrophysics Data System (ADS)

Sorba, Robert; Sawicki, Marcin

2018-05-01

We perform spatially resolved, pixel-by-pixel Spectral Energy Distribution (SED) fitting on galaxies up to z ˜ 2.5 in the Hubble eXtreme Deep Field (XDF). Comparing stellar mass estimates from spatially resolved and spatially unresolved photometry we find that unresolved masses can be systematically underestimated by factors of up to 5. The ratio of the unresolved to resolved mass measurement depends on the galaxy's specific star formation rate (sSFR): at low sSFRs the bias is small, but above sSFR ˜ 10-9.5 yr-1 the discrepancy increases rapidly such that galaxies with sSFRs ˜ 10-8 yr-1 have unresolved mass estimates of only one-half to one-fifth of the resolved value. This result indicates that stellar masses estimated from spatially unresolved data sets need to be systematically corrected, in some cases by large amounts, and we provide an analytic prescription for applying this correction. We show that correcting stellar mass measurements for this bias changes the normalization and slope of the star-forming main sequence and reduces its intrinsic width; most dramatically, correcting for the mass bias increases the stellar mass density of the Universe at high redshift and can resolve the long-standing discrepancy between the directly measured cosmic SFR density at z ≳ 1 and that inferred from stellar mass densities (`the missing mass problem').

Spatially Resolved Spectroscopy of Narrow-line Seyfert 1 Host Galaxies

NASA Astrophysics Data System (ADS)

Scharwächter, J.; Husemann, B.; Busch, G.; Komossa, S.; Dopita, M. A.

2017-10-01

We present optical integral field spectroscopy for five z< 0.062 narrow-line Seyfert 1 (NLS1) galaxies, probing their host galaxies at ≳ 2{--}3 {kpc} scales. Emission lines from the active galactic nucleus (AGN) and the large-scale host galaxy are analyzed separately, based on an AGN-host decomposition technique. The host galaxy gas kinematics indicates large-scale gas rotation in all five sources. At the probed scales of ≳ 2{--}3 {kpc}, the host galaxy gas is found to be predominantly ionized by star formation without any evidence of a strong AGN contribution. None of the five objects shows specific star formation rates (SFRs) exceeding the main sequence of low-redshift star-forming galaxies. The specific SFRs for MCG-05-01-013 and WPVS 007 are roughly consistent with the main sequence, while ESO 399-IG20, MS 22549-3712, and TON S180 show lower specific SFRs, intermediate to the main sequence and the red quiescent galaxies. The host galaxy metallicities, derived for the two sources with sufficient data quality (ESO 399-IG20 and MCG-05-01-013), indicate central oxygen abundances just below the low-redshift mass-metallicity relation. Based on this initial case study, we outline a comparison of AGN and host galaxy parameters as a starting point for future extended NLS1 studies with similar methods.

GAMA/H-ATLAS: the ultraviolet spectral slope and obscuration in galaxies

NASA Astrophysics Data System (ADS)

Wijesinghe, D. B.; da Cunha, E.; Hopkins, A. M.; Dunne, L.; Sharp, R.; Gunawardhana, M.; Brough, S.; Sadler, E. M.; Driver, S.; Baldry, I.; Bamford, S.; Liske, J.; Loveday, J.; Norberg, P.; Peacock, J.; Popescu, C. C.; Tuffs, R.; Andrae, E.; Auld, R.; Baes, M.; Bland-Hawthorn, J.; Buttiglione, S.; Cava, A.; Cameron, E.; Conselice, C. J.; Cooray, A.; Croom, S.; Dariush, A.; Dezotti, G.; Dye, S.; Eales, S.; Frenk, C.; Fritz, J.; Hill, D.; Hopwood, R.; Ibar, E.; Ivison, R.; Jarvis, M.; Jones, D. H.; van Kampen, E.; Kelvin, L.; Kuijken, K.; Maddox, S. J.; Madore, B.; Michałowski, M. J.; Nichol, B.; Parkinson, H.; Pascale, E.; Pimbblet, K. A.; Pohlen, M.; Prescott, M.; Rhodighiero, G.; Robotham, A. S. G.; Rigby, E. E.; Seibert, M.; Sergeant, S.; Smith, D. J. B.; Temi, P.; Sutherland, W.; Taylor, E.; Thomas, D.; van der Werf, P.

2011-08-01

We use multiwavelength data from the Galaxy And Mass Assembly (GAMA) and Herschel-ATLAS (H-ATLAS) surveys to compare the relationship between various dust obscuration measures in galaxies. We explore the connections between the ultraviolet (UV) spectral slope, β, the Balmer decrement and the far-infrared (FIR) to 150 nm far-ultraviolet (FUV) luminosity ratio. We explore trends with galaxy mass, star formation rate (SFR) and redshift in order to identify possible systematics in these various measures. We reiterate the finding of other authors that there is a large scatter between the Balmer decrement and the β parameter, and that β may be poorly constrained when derived from only two broad passbands in the UV. We also emphasize that FUV-derived SFRs, corrected for dust obscuration using β, will be overestimated unless a modified relation between β and the attenuation factor is used. Even in the optimum case, the resulting SFRs have a significant scatter, well over an order of magnitude. While there is a stronger correlation between the IR-to-FUV luminosity ratio and β parameter than with the Balmer decrement, neither of these correlations are particularly tight, and dust corrections based on β for high-redshift galaxy SFRs must be treated with caution. We conclude with a description of the extent to which the different obscuration measures are consistent with each other as well as the effects of including other galactic properties on these correlations.

Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia.

PubMed

Perez-Marques, Francesca; Simpson, Pippa; Yan, Ke; Quasney, Michael W; Halligan, Nadine; Merchant, Daniel; Dahmer, Mary K

2016-09-05

Previous work has demonstrated a strong association between lung injury in African American children with pneumonia and a polymorphic (TG)mTn region in cystic fibrosis transmembrane conductance (CFTR) involved in the generation of a nonfunctional CFTR protein lacking exon 9. A number of splicing factors that regulate the inclusion/exclusion of exon 9 have been identified. The objective of this study was to determine whether genetic variants in these splicing factors were associated with acute respiratory distress syndrome (ARDS) in children with pneumonia. This is a prospective cohort genetic association study of lung injury in African American and non-Hispanic Caucasian children with community-acquired pneumonia evaluated in the emergency department or admitted to the hospital. Linkage-disequilibrium-tag single nucleotide polymorphisms (LD-tag SNPs) in genes of the following splicing factors (followed by gene name) involved in exon 9 skipping PTB1 (PTBP1), SRp40 (SFRS1), SR2/ASF (SFRS5), TDP-43 (TARDBP), TIA-1 (TIA1), and U2AF(65) (U2AF2) were genotyped. SNPs in the gene of the splicing factor CELF2 (CELF2) were selected by conservation score. Multivariable analysis was used to examine association between genotypes and ARDS. The African American cohort (n = 474) had 29 children with ARDS and the non-Hispanic Caucasian cohort (n = 304) had 32 children with ARDS. In the African American group multivariable analysis indicated that three variants in CELF2, rs7068124 (p = 0.004), rs3814634 (p = 0.032) and rs10905928 (p = 0.044), and two in TIA1, rs2592178 (p = 0.005) and rs13402990 (p = 0.018) were independently associated with ARDS. In the non-Hispanic Caucasian group, a single variant in CELF2, rs2277212 (p = 0.014), was associated with increased risk of developing ARDS. The data indicate that SNPs in CELF2 may be associated with the risk of developing ARDS in both African American and non-Hispanic Caucasian children with pneumonia and suggest that the potential role of the splicing factor CELF2 in ARDS should be explored further.

Structured Forms Reference Set of Binary Images (SFRS)

National Institute of Standards and Technology Data Gateway

NIST Structured Forms Reference Set of Binary Images (SFRS) (Web, free access)   The NIST Structured Forms Database (Special Database 2) consists of 5,590 pages of binary, black-and-white images of synthesized documents. The documents in this database are 12 different tax forms from the IRS 1040 Package X for the year 1988.

The Luminous Polycyclic Aromatic Hydrocarbon Emission Features: Applications to High Redshift Galaxies and Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Shipley, Heath V.

2016-01-01

For decades, significant work has been applied to calibrating emission from the ultra-violet, nebular emission lines, far-infrared, X-ray and radio as tracers of the star-formation rate (SFR) in distant galaxies. Understanding the exact rate of star-formation and how it evolves with time and galaxy mass has deep implications for how galaxies form. The co-evolution of star-formation and supermassive black hole (SMBH) accretion is one of the key problems in galaxy formation theory. But, many of these SFR indicators are influenced by SMBH accretion in galaxies and result in unreliable SFRs. Utilizing the luminous polycyclic aromatic hydrocarbon (PAH) emission features, I provide a new robust SFR calibration using the luminosity emitted from the PAHs at 6.2μm, 7.7μm and 11.3μm to solve this. The PAH features emit strongly in the mid-infrared (mid-IR; 5-25μm) mitigating dust extinction, containing on average 5-10% of the total IR luminosity in galaxies. I use a sample of 105 star-forming galaxies covering a range of total IR luminosity, LIR = L(8-1000μm) = 109 - 1012 L⊙ and redshift 0 < z < 0.4, with mid-IR spectroscopy from the Spitzer Infrared Spectrograph (IRS), and data covering other SFR indicators (Hα emission and rest-frame 24μm continuum emission). The PAH luminosity correlates linearly with the SFR as measured by the Hα luminosity (corrected for attenuation using the mono-chromatic rest-frame 24μm emission), with a tight scatter of <0.15 dex. The scatter is comparable to that between SFRs derived from the Paα and dust-corrected Hα emission lines. We present a case study in advance of JWST, which will be capable of measuring SFRs (from 8μm rest-frame photometry, i.e. PAHs) in distant galaxies (z ≤ 2) with JWST/MIRI to SFRs as low as ~10 M⊙yr-1, because the PAH features are so bright. We use Spitzer/IRS observations of PAH features in lensed star-forming galaxies at 1 < z < 3 to demonstrate the utility of the PAHs to derive SFRs that agree with those available from Paα. This new SFR indicator will be useful for probing the peak of the SFR density in the universe (1 < z < 3) and for studying the co-evolution of star-formation and supermassive blackhole accretion contemporaneously in a galaxy.

Tracing the Far-Infrared Roles of AGN in Dusty Star-Forming Galaxies

NASA Astrophysics Data System (ADS)

Brown, Arianna; Nayyeri, Hooshang; Cooray, Asantha R.; Mitchell-Wynne, Ketron

2017-01-01

Active galactic nuclei (AGNs) are suggested to play an important role in quenching their host galaxy’s star formation rate (SFR) by heating up and/or consuming the cool gas necessary to create stars. This mechanism is theorized as a critical step in AGN evolutionary models. The efforts to study this effect suffer in part from low-number statistics at high x-ray luminosities (LXR > 1044 ergs/s) for AGNs at z≈1-3, and a lack of separately estimated SFRs for AGN in dusty, star-forming galaxies (DSFGs). In this work, we extend our analysis to build a more complete picture using the variety of available multi-wavelength data in the XBoötes region. The Chandra XBoötes Survey is a 5-ks X-ray survey of the 9.3 square degree Boötes Field of the NOAO Deep Wide-Field Survey, a survey imaged from the optical to the near-IR. We estimate AGN spectral energy distributions and SFRs for ~400 x-ray sources using available data in all four Spitzer IRAC bands, the Spitzer MIPS 24µm band, all five Herschel SPIRE and PACS bands, along with NEWFIRM optical bands. Preliminary results show an exponential correlation between x-ray luminosity and star formation. As a comparison, we will use a stacking technique for the ~500 x-ray sources that were not detected at submillimeter wavelengths, where sources are binned by x-ray luminosity. We will compare these two samples and expect to see a difference in slope. Using these techniques, we hope to place tighter constraints on the mean SFRs of high-luminosity AGNs inside DSFGs, and determine if x-ray luminosities are independent of average SFRs for our sample in the Boötes field.

A catalogue of faint local radio AGN and the properties of their host galaxies

NASA Astrophysics Data System (ADS)

Lofthouse, E. K.; Kaviraj, S.; Smith, D. JB; Hardcastle, M. J.

2018-05-01

We present a catalogue of local (z < 0.1) galaxies that contain faint AGN. We select these objects by identifying galaxies that exhibit a significant excess in their radio luminosities, compared to what is expected from the observed levels of star-formation activity in these systems. This is achieved by comparing the optical (spectroscopic) star formation rate (SFR) to the 1.4 GHz luminosity measured from the FIRST survey. The majority of the AGN identified in this study are fainter than those in previous work, such as in the Best and Heckman (2012) catalogue. We show that these faint AGN make a non-negligible contribution to the radio luminosity function at low luminosities (below 1022.5 W Hz-1), and host ˜13 per cent of the local radio luminosity budget. Their host galaxies are predominantly high stellar-mass systems (with a median stellar mass of 1011M⊙), are found across a range of environments (but typically in denser environments than star-forming galaxies) and have early-type morphologies. This study demonstrates a general technique to identify AGN in galaxy populations where reliable optical SFRs can be extracted using spectro-photometry and where radio data are also available so that a radio excess can be measured. Our results also demonstrate that it is unsafe to infer SFRs from radio emission alone, even if bright AGN have been excluded from a sample, since there is a significant population of faint radio AGN which may contaminate the radio-derived SFRs.

Structured Forms Reference Set of Binary Images II (SFRS2)

National Institute of Standards and Technology Data Gateway

NIST Structured Forms Reference Set of Binary Images II (SFRS2) (Web, free access)   The second NIST database of structured forms (Special Database 6) consists of 5,595 pages of binary, black-and-white images of synthesized documents containing hand-print. The documents in this database are 12 different tax forms with the IRS 1040 Package X for the year 1988.

Spitzer observations of red galaxies: Implication for high-redshift star formation

NASA Astrophysics Data System (ADS)

Papovich, Casey

2006-03-01

My colleagues and I identified distant red galaxies (DRGs) with J - Ks > 2.3 in the southern Great Observatories Origins Deep Surveys (GOODS-S) field. These galaxies reside at z ˜ 1-3.5, (< z> ≃ 2.2) and based on their ACS (0.4-1 μm), ISAAC (1-2.2 μm), and IRAC (3-8 μm) photometry, they typically have stellar masses M ⩾ 10 11 M⊙. Interestingly, more than 50% of these objects have 24 μm flux densities ⩾50 μJy. Attributing the IR emission to star-formation implies star-formation rates (SFRs) of ≃100-1000 M⊙ yr -1. As a result, galaxies with M ⩾ 10 11 M⊙ have specific SFRs equal to or exceeding the global value at z ˜ 1.5-3. In contrast, galaxies with M ⩾ 10 11 M⊙ at z ˜ 0.3-0.75 have specific SFRs less than the global average, and more than an order of magnitude lower than that for massive DRGs at z ˜ 1.5-3. Thus, the bulk of star formation in massive galaxies is largely complete by z ˜ 1.5. The red colors and large inferred stellar masses in the DRGs suggest that much of the star formation in these galaxies occurred at redshifts z ≳ 5-6. Using model star-formation histories that match the DRG colors and stellar masses at z ˜ 2-3, and measurements of the UV luminosity density at z ≳ 5-6, we consider what constraints exist on the stellar initial mass function in the progenitors of the massive DRGs at z ˜ 2-3.

Characterizing Protoplanetary Disks in a Young Binary in Orion

NASA Astrophysics Data System (ADS)

Powell, Jonas; Hughes, A. Meredith; Mann, Rita; Flaherty, Kevin; Di Francesco, James; Williams, Jonathan

2018-01-01

Planetary systems form in circumstellar disks of gas and dust surrounding young stars. One open question in the study of planet formation involves understanding how different environments affect the properties of the disks and planets they generate. Understanding the properties of disks in high-mass star forming regions (SFRs) is critical since most stars - probably including our Sun - form in those regions. By comparing the disks in high-mass SFRs to those in better-studied low-mass SFRs we can learn about the role environment plays in planet formation. Here we present 0.5" resolution observations of the young two-disk binary system V2434 Ori in the Orion Nebula from the Atacama Large Millimeter/submillimeter Array (ALMA) in molecular line tracers of CO(3-2), HCN(4-3), HCO+(4-3) and CS(7-6). We model each disk’s mass, radius, temperature structure, and molecular abundances, by creating synthetic images using an LTE ray-tracing code and comparing simulated observations with the ALMA data in the visibility domain. We then compare our results to a previous study of molecular line emission from a single Orion proplyd, modeled using similar methods, and to previously characterized disks in low-mass SFRs to investigate the role of environment in disk chemistry and planetary system formation.

The Ultraviolet and Infrared Star Formation Rates of Compact Group Galaxies: An Expanded Sample

NASA Technical Reports Server (NTRS)

Lenkic, Laura; Tzanavaris, Panayiotis; Gallagher, Sarah C.; Desjardins, Tyler D.; Walker, Lisa May; Johnson, Kelsey E.; Fedotov, Konstantin; Charlton, Jane; Cardiff, Ann H.; Durell, Pat R.

2016-01-01

Compact groups of galaxies provide insight into the role of low-mass, dense environments in galaxy evolution because the low velocity dispersions and close proximity of galaxy members result in frequent interactions that take place over extended time-scales. We expand the census of star formation in compact group galaxies by Tzanavaris et al. (2010) and collaborators with Swift UVOT, Spitzer IRAC and MIPS 24 m photometry of a sample of 183 galaxies in 46 compact groups. After correcting luminosities for the contribution from old stellar populations, we estimate the dust-unobscured star formation rate (SFRUV) using the UVOT uvw2 photometry. Similarly, we use the MIPS 24 m photometry to estimate the component of the SFR that is obscured by dust (SFRIR). We find that galaxies which are MIR-active (MIR-red), also have bluer UV colours, higher specific SFRs, and tend to lie in Hi-rich groups, while galaxies that are MIR-inactive (MIR-blue) have redder UV colours, lower specific SFRs, and tend to lie in Hi-poor groups. We find the SFRs to be continuously distributed with a peak at about 1 M yr1, indicating this might be the most common value in compact groups. In contrast, the specific SFR distribution is bimodal, and there is a clear distinction between star-forming and quiescent galaxies. Overall, our results suggest that the specific SFR is the best tracer of gas depletion and galaxy evolution in compact groups.

The Discovery of Lensed Radio and X-ray Sources Behind the Frontier Fields Cluster MACS J0717.5+3745 with the JVLA and Chandra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weeren, R. J. van; Ogrean, G. A.; Jones, C.

We report on high-resolution JVLA and Chandra observations of the Hubble Space Telescope (HST) Frontier Cluster MACS J0717.5+3745. MACS J0717.5+3745 offers the largest contiguous magnified area of any known cluster, making it a promising target to search for lensed radio and X-ray sources. With the high-resolution 1.0–6.5 GHz JVLA imaging in A and B configuration, we detect a total of 51 compact radio sources within the area covered by the HST imaging. Within this sample, we find seven lensed sources with amplification factors larger than two. None of these sources are identified as multiply lensed. Based on the radio luminosities,more » the majority of these sources are likely star-forming galaxies with star-formation rates (SFRs) of 10–50 M ⊙ yr -1 located at 1≲ z ≲ 2. Two of the lensed radio sources are also detected in the Chandra image of the cluster. These two sources are likely active galactic nuclei, given their 2–10 keV X-ray luminosities of ~ 10 43-44 erg s -1. From the derived radio luminosity function, we find evidence for an increase in the number density of radio sources at 0.6 < z < 2.0, compared to a z < 0.3 sample. Lastly, our observations indicate that deep radio imaging of lensing clusters can be used to study star-forming galaxies, with SFRs as low as ~10M ⊙ yr -1, at the peak of cosmic star formation history.« less

The Discovery of Lensed Radio and X-ray Sources Behind the Frontier Fields Cluster MACS J0717.5+3745 with the JVLA and Chandra

DOE PAGES

Weeren, R. J. van; Ogrean, G. A.; Jones, C.; ...

2016-01-27

We report on high-resolution JVLA and Chandra observations of the Hubble Space Telescope (HST) Frontier Cluster MACS J0717.5+3745. MACS J0717.5+3745 offers the largest contiguous magnified area of any known cluster, making it a promising target to search for lensed radio and X-ray sources. With the high-resolution 1.0–6.5 GHz JVLA imaging in A and B configuration, we detect a total of 51 compact radio sources within the area covered by the HST imaging. Within this sample, we find seven lensed sources with amplification factors larger than two. None of these sources are identified as multiply lensed. Based on the radio luminosities,more » the majority of these sources are likely star-forming galaxies with star-formation rates (SFRs) of 10–50 M ⊙ yr -1 located at 1≲ z ≲ 2. Two of the lensed radio sources are also detected in the Chandra image of the cluster. These two sources are likely active galactic nuclei, given their 2–10 keV X-ray luminosities of ~ 10 43-44 erg s -1. From the derived radio luminosity function, we find evidence for an increase in the number density of radio sources at 0.6 < z < 2.0, compared to a z < 0.3 sample. Lastly, our observations indicate that deep radio imaging of lensing clusters can be used to study star-forming galaxies, with SFRs as low as ~10M ⊙ yr -1, at the peak of cosmic star formation history.« less

VizieR Online Data Catalog: SFiNCs: X-ray, IR and membership catalogs (Getman+, 2017)

NASA Astrophysics Data System (ADS)

Getman, K. V.; Broos, P. S.; Kuhn, M. A.; Feigelson, E. D.; Richert, A. J. W.; Ota, Y.; Bate, M. R.; Garmire, G. P.

2017-06-01

Sixty five X-ray observations for the 22 Star Formation in Nearby Clouds (SFiNCs) star-forming regions (SFRs) (see tables 1 and 2), made with the imaging array on the Advanced CCD Imaging Spectrometer (ACIS), were pulled from the Chandra archive (spanning 2000 Jan to 2015 Apr; see table 2). Our final Chandra-ACIS catalog for the 22 SFiNCs SFRs comprises 15364 X-ray sources (Tables 3 and 4 and section 3.2). To obtain MIR photometry for X-ray objects and to identify and measure MIR photometry for additional non-Chandra disky stars that were missed in previous studies of the SFiNCs regions (typically faint YSOs), we have reduced the archived Spitzer-IRAC data by homogeneously applying the MYStIX-based Spitzer-IRAC data reduction methods of Kuhn+ (2013, J/ApJS/209/29) to the 423 Astronomical Object Request (AORs) data sets for the 22 SFiNCs SFRs (Table 5). As in MYStIX, here the SFiNCs IRAC source catalog retains all point sources with the photometric signal-to-noise ratio >5 in both [3.6] and [4.5] channels. This catalog covers the 22 SFiNCs SFRs and their vicinities on the sky and comprises 1638654 IRAC sources with available photometric measurements for 100%, 100%, 29%, and 23% of these sources in the 3.6, 4.5, 5.8, and 8.0um bands, respectively (see table 6 and section 3.4). Source position cross correlations between the SFiNCs Chandra X-ray source catalog and an IR catalog, either the "cut-out" IRAC or 2MASS, were made using the steps described in section 3.5. Tables 7 and 8 provide the list of 8492 SFiNCs probable cluster members (SPCMs) and their main IR and X-ray properties (see section 4). (9 data files).

ESTIMATING THE STAR FORMATION RATE AT 1 kpc SCALES IN NEARBY GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leroy, Adam K.; Munoz-Mateos, Juan-Carlos; Bigiel, Frank

2012-07-15

Using combinations of H{alpha}, ultraviolet (UV), and infrared (IR) emission, we estimate the star formation rate (SFR) surface density, {Sigma}{sub SFR}, at 1 kpc resolution for 30 disk galaxies that are targets of the IRAM HERACLES CO survey. We present a new physically motivated IR spectral-energy-distribution-based approach to account for possible contributions to 24 {mu}m emission not associated with recent star formation. Considering a variety of 'reference' SFRs from the literature, we revisit the calibration of the 24 {mu}m term in hybrid (UV+IR or H{alpha}+IR) tracers. We show that the overall calibration of this term remains uncertain at the factormore » of two level because of the lack of wide-field, robust reference SFR estimates. Within this uncertainty, published calibrations represent a reasonable starting point for 1 kpc-wide areas of star-forming disk galaxies, but we re-derive and refine the calibration of the IR term in these tracers to match our resolution and approach to 24 {mu}m emission. We compare a large suite of {Sigma}{sub SFR} estimates and find that above {Sigma}{sub SFR} {approx} 10{sup -3} M{sub Sun} yr{sup -1} kpc{sup -2} the systematic differences among tracers are less than a factor of two across two orders of magnitude dynamic range. We caution that methodology and data both become serious issues below this level. We note from simple model considerations that when focusing on a part of a galaxy dominated by a single stellar population, the intrinsic uncertainty in H{alpha}- and FUV-based SFRs is {approx}0.3 and {approx}0.5 dex.« less

The Star Formation Reference Survey - II. Activity demographics and host-galaxy properties for infrared-selected galaxies

NASA Astrophysics Data System (ADS)

Maragkoudakis, A.; Zezas, A.; Ashby, M. L. N.; Willner, S. P.

2018-04-01

We present activity demographics and host-galaxy properties of infrared-selected galaxies in the local Universe, using the representative Star Formation Reference Survey (SFRS). Our classification scheme is based on a combination of optical emission-line diagrams (BPT) and infrared (IR)-colour diagnostics. Using the weights assigned to the SFRS galaxies based on its parent sample, a far-IR-selected sample comprises 71 per cent H II galaxies, 13 per cent Seyferts, 3 per cent transition objects (TOs), and 13 per cent low-ionization nuclear emission-line regions (LINERs). For the SFRS H II galaxies, we derive nuclear star formation rates and gas-phase metallicities. We measure host-galaxy metallicities for all galaxies with available long-slit spectroscopy and abundance gradients for a subset of 12 face-on galaxies. The majority of H II galaxies show a narrow range of metallicities, close to solar, and flat metallicity profiles. Based on their host-galaxy and nuclear properties, the dominant ionizing source in the far-infrared selected TOs is star-forming activity. LINERs are found mostly in massive hosts (median of 1010.5 M⊙), median L(60 μm) = 109 L⊙, median dust temperatures of F60/F100 = 0.36, and median LH α surface density of 1040.2 erg s-1kpc-2, indicating older stellar populations as their main ionizing source rather than active galactic nucleus activity.

A Multi-Wavelength Census of Dust and Star Formation in Galaxies at z ~ 2

NASA Astrophysics Data System (ADS)

Shivaei, Irene; Reddy, Naveen; MOSDEF Collaboration

2017-01-01

Redshift of z ~ 2 is an important era in the history of the universe, as it contains the peak of star formation rate density and quasar activity. We study the galaxy properties during this era from two different, yet complementary, aspects: by studying formation of stars and mass assembly, and exploring the properties of galactic dust. We use a wealth of multi-wavelength data, from UV to far-IR, to obtain a complete census of obscured and unobscured star formation in galaxies. Our data consists of rest-frame optical spectra from the MOSDEF survey, rest-frame UV and optical photometric data from the 3D-HST survey, and mid- and far-IR data obtained by the Spitzer and Herschel telescopes. In the MOSDEF survey, we acquired rest-frame optical spectra of ~ 1500 galaxies with the MOSFIRE spectrograph on the Keck I telescope. MOSDEF is currently the largest survey of the rest-frame optical properties of galaxies at 1.37 ≤ z ≤ 3.80. Using the multi-wavelength data sets, we show that Hα SFRs, corrected for dust attenuation using the Hβ line, accurately trace SFRs up to ~ 300 M⊙ yr-1, when compared with panchromatic (UV-to-far-IR) SED models. Using Hα SFRs for a large sample of ~ 200 galaxies at z ~ 2, we explore the SFR-M* relation and show that the slope of this relation is shallower than previously measured. We conclude that the scatter in the SFR-M* relation is dominated by uncertainties in dust correction and cannot be used to measure the star formation stochasticity. Furthermore, we investigate the robustness of Spitzer/MIPS 24 micron flux as an SFR indicator and its variation with ISM physical parameters. We find that 24 micron flux, which at z ~ 2 traces the emission from the PAH grains, significantly depends on metallicity, such that there is a PAH deficiency in metal-poor galaxies. We demonstrate that commonly-used conversions of 24 micron flux to IR luminosity underestimate the IR luminosity of low-mass galaxies by more than a factor of 2. Our results suggest a higher specific SFR (i.e., SFR/M*) at M* ~ 109.5M⊙ and a higher IR luminosity density at z ~ 2 than previously measured. The latter corresponds to a ~ 30% increase in the SFR density.

The Relationship Between Brightest Cluster Galaxy Star Formation and the Intracluster Medium in CLASH

NASA Astrophysics Data System (ADS)

Fogarty, Kevin; Postman, Marc; Larson, Rebecca; Donahue, Megan; Moustakas, John

2017-09-01

We study the nature of feedback mechanisms in the 11 CLASH brightest cluster galaxies (BCGs) that exhibit extended ultraviolet and nebular line emission features. We estimate star formation rates (SFRs), dust masses, and starburst durations using a Bayesian photometry-fitting technique that accounts for both stellar and dust emission from the UV through far-IR. By comparing these quantities to intracluster medium (ICM) cooling times and freefall times derived from X-ray observations and lensing estimates of the cluster mass distribution, we discover a tight relationship between the BCG SFR and the ICM cooling time to freefall time ratio, {t}{cool}/{t}{ff}, with an upper limit on the intrinsic scatter of 0.15 dex. Furthermore, starburst durations may correlate with ICM cooling times at a radius of 0.025 {R}500, and the two quantities converge upon reaching the gigayear regime. Our results provide a direct observational link between the thermodynamical state of the ICM and the intensity and duration of BCG star formation activity, and appear consistent with a scenario where active galactic nuclei induce condensation of thermally unstable ICM overdensities that fuel long-duration (>1 Gyr) BCG starbursts. This scenario can explain (a) how gas with a low cooling time is depleted without causing a cooling flow and (b) the scaling relationship between SFR and {t}{cool}/{t}{ff}. We also find that the scaling relation between SFR and dust mass in BCGs with SFRs < 100 {M}⊙ yr-1 is similar to that in star-forming field galaxies; BCGs with large (> 100 {M}⊙ yr-1) SFRs have dust masses comparable to extreme starbursts.

Combining physical galaxy models with radio observations to constrain the SFRs of high-z dusty star-forming galaxies

NASA Astrophysics Data System (ADS)

Lo Faro, B.; Silva, L.; Franceschini, A.; Miller, N.; Efstathiou, A.

2015-03-01

We complement our previous analysis of a sample of z ˜ 1-2 luminous and ultraluminous infrared galaxies [(U)LIRGs], by adding deep Very Large Array radio observations at 1.4 GHz to a large data set from the far-UV to the submillimetre, including Spitzer and Herschel data. Given the relatively small number of (U)LIRGs in our sample with high signal-to-noise (S/N) radio data, and to extend our study to a different family of galaxies, we also include six well-sampled near-infrared (near-IR)-selected BzK galaxies at z ˜ 1.5. From our analysis based on the radtran spectral synthesis code GRASIL, we find that, while the IR luminosity may be a biased tracer of the star formation rate (SFR) depending on the age of stars dominating the dust heating, the inclusion of the radio flux offers significantly tighter constraints on SFR. Our predicted SFRs are in good agreement with the estimates based on rest-frame radio luminosity and the Bell calibration. The extensive spectrophotometric coverage of our sample allows us to set important constraints on the star formation (SF) history of individual objects. For essentially all galaxies, we find evidence for a rather continuous SFR and a peak epoch of SF preceding that of the observation by a few Gyr. This seems to correspond to a formation redshift of z ˜ 5-6. We finally show that our physical analysis may affect the interpretation of the SFR-M⋆ diagram, by possibly shifting, with respect to previous works, the position of the most dust obscured objects to higher M⋆ and lower SFRs.

The Lesser Role of Starbursts in Star Formation at z = 2

NASA Astrophysics Data System (ADS)

Rodighiero, G.; Daddi, E.; Baronchelli, I.; Cimatti, A.; Renzini, A.; Aussel, H.; Popesso, P.; Lutz, D.; Andreani, P.; Berta, S.; Cava, A.; Elbaz, D.; Feltre, A.; Fontana, A.; Förster Schreiber, N. M.; Franceschini, A.; Genzel, R.; Grazian, A.; Gruppioni, C.; Ilbert, O.; Le Floch, E.; Magdis, G.; Magliocchetti, M.; Magnelli, B.; Maiolino, R.; McCracken, H.; Nordon, R.; Poglitsch, A.; Santini, P.; Pozzi, F.; Riguccini, L.; Tacconi, L. J.; Wuyts, S.; Zamorani, G.

2011-10-01

Two main modes of star formation are know to control the growth of galaxies: a relatively steady one in disk-like galaxies, defining a tight star formation rate (SFR)-stellar mass sequence, and a starburst mode in outliers to such a sequence which is generally interpreted as driven by merging. Such starburst galaxies are rare but have much higher SFRs, and it is of interest to establish the relative importance of these two modes. PACS/Herschel observations over the whole COSMOS and GOODS-South fields, in conjunction with previous optical/near-IR data, have allowed us to accurately quantify for the first time the relative contribution of the two modes to the global SFR density in the redshift interval 1.5 < z < 2.5, i.e., at the cosmic peak of the star formation activity. The logarithmic distributions of galaxy SFRs at fixed stellar mass are well described by Gaussians, with starburst galaxies representing only a relatively minor deviation that becomes apparent for SFRs more than four times higher than on the main sequence. Such starburst galaxies represent only 2% of mass-selected star-forming galaxies and account for only 10% of the cosmic SFR density at z ~ 2. Only when limited to SFR > 1000 M sun yr-1, off-sequence sources significantly contribute to the SFR density (46% ± 20%). We conclude that merger-driven starbursts play a relatively minor role in the formation of stars in galaxies, whereas they may represent a critical phase toward the quenching of star formation and morphological transformation in galaxies.

THE MOLECULAR GAS DENSITY IN GALAXY CENTERS AND HOW IT CONNECTS TO BULGES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisher, David B.; Bolatto, Alberto; Drory, Niv

2013-02-20

In this paper we present gas density, star formation rate (SFR), stellar masses, and bulge-disk decompositions for a sample of 60 galaxies. Our sample is the combined sample of the BIMA SONG, CARMA STING, and PdBI NUGA surveys. We study the effect of using CO-to-H{sub 2} conversion factors that depend on the CO surface brightness, and also that of correcting SFRs for diffuse emission from old stellar populations. We estimate that SFRs in bulges are typically lower by 20% when correcting for diffuse emission. Using the surface brightness dependent conversion factor, we find that over half of the galaxies inmore » our sample have {Sigma}{sub mol} > 100 M {sub Sun} pc{sup -2}. Though our sample is not complete in any sense, our results are enough to rule out the assumption that bulges are uniformly gas-poor systems. We find a trend between gas density of bulges and bulge Sersic index; bulges with lower Sersic index have higher gas density. Those bulges with low Sersic index (pseudobulges) have gas fractions that are similar to that of disks. Conversely, the typical molecular gas fraction in classical bulges is more similar to that of an elliptical galaxy. We also find that there is a strong correlation between bulges with the highest gas surface density and the galaxy being barred. However, we also find that classical bulges with low gas surface density can be barred as well. Our results suggest that understanding the connection between the central surface density of gas in disk galaxies and the presence of bars should also take into account the total gas content of the galaxy. Finally, we show that when using the corrected SFRs and gas densities, the correlation between SFR surface density and gas surface density of bulges is similar to that of disks. This implies that at the scale of the bulges the timescale for converting gas into stars is comparable to those results found in disks.« less

THE MOST MASSIVE GALAXIES AT 3.0 {<=} z < 4.0 IN THE NEWFIRM MEDIUM-BAND SURVEY: PROPERTIES AND IMPROVED CONSTRAINTS ON THE STELLAR MASS FUNCTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchesini, Danilo; Whitaker, Katherine E.; Brammer, Gabriel

2010-12-10

We use the optical to mid-infrared coverage of the NEWFIRM Medium-Band Survey (NMBS) to characterize, for the first time, the properties of a mass-complete sample of 14 galaxies at 3.0 {<=} z < 4.0 with M{sub star}>2.5 x 10{sup 11} M{sub sun}, and to derive significantly more accurate measurements of the high-mass end of the stellar mass function (SMF) of galaxies at 3.0 {<=} z < 4.0. The accurate photometric redshifts and well-sampled spectral energy distributions (SEDs) provided by the NMBS combined with the large surveyed area result in significantly reduced contributions from photometric redshift errors and cosmic variance tomore » the total error budget of the SMF. The typical very massive galaxy at 3.0 {<=} z < 4.0 is red and faint in the observer's optical, with a median r-band magnitude of (r{sub tot}) = 26.1, and median rest-frame U - V colors of (U - V) = 1.6. About 60% of the mass-complete sample has optical colors satisfying either the U- or the B-dropout color criteria, although {approx}50% of these galaxies has r>25.5. We find that {approx}30% of the sample has star formation rates (SFRs) from SED modeling consistent with zero, although SFRs of up to {approx}1-18 M{sub sun} yr{sup -1} are also allowed within 1{sigma}. However, >80% of the sample is detected at 24 {mu}m, resulting in total infrared luminosities in the range (0.5-4.0) x 10{sup 13} L{sub sun}. This implies the presence of either dust-enshrouded starburst activity (with SFRs of 600-4300 M{sub sun} yr{sup -1}) and/or highly obscured active galactic nuclei (AGNs). The contribution of galaxies with M{sub star}>2.5 x 10{sup 11} M{sub sun} to the total stellar mass budget at 3.0 {<=} z < 4.0 is {approx}8{sup +13}{sub -3}%. Compared to recent estimates of the stellar mass density in galaxies with M{sub star} {approx} 10{sup 9}-10{sup 11} M{sub sun} at z {approx} 5 and z {approx} 6, we find an evolution by a factor of 2-7 and 3-22 from z {approx} 5 and z {approx} 6, respectively, to z = 3.5. The previously found disagreement at the high-mass end between observed and model-predicted SMFs is now significant at the 3{sigma} level when only random uncertainties are considered. However, systematic uncertainties dominate the total error budget, with errors up to a factor of {approx}8 in the densities at the high-mass end, bringing the observed SMF in marginal agreement with the predicted SMF. Additional systematic uncertainties on the high-mass end could be potentially introduced by either (1) the intense star formation and/or the very common AGN activities as inferred from the MIPS 24 {mu}m detections, and/or (2) contamination by a significant population of massive, old, and dusty galaxies at z {approx} 2.6.« less

What are the Progenitors of Compace, Massive, Quiescent Galaxies at z (equals) 2.3? The Population of Massive Galaxies at z (greater than) 3 From NMBS AND CANDELS

NASA Technical Reports Server (NTRS)

Stefanon, Mauro; Marchesini, Danilo; Rudnick, Gregory H.; Brammer, Gabriel B.; Tease, Katherine Whitaker

2013-01-01

Using public data from the NEWFIRM Medium-Band Survey (NMBS) and the Cosmic Assembly Near-Infrared Deep Extragalactic Legacy Survey (CANDELS), we investigate the population of massive galaxies at z > 3. The main aim of this work is to identify the potential progenitors of z 2 compact, massive, quiescent galaxies (CMQGs), furthering our understanding of the onset and evolution of massive galaxies. Our work is enabled by high-resolution images from CANDELS data and accurate photometric redshifts, stellar masses, and star formation rates (SFRs) from 37-band NMBS photometry. The total number of massive galaxies at z > 3 is consistent with the number of massive, quiescent galaxies (MQGs) at z 2, implying that the SFRs for all of these galaxies must be much lower by z 2. We discover four CMQGs at z > 3, pushing back the time for which such galaxies have been observed. However, the volume density for these galaxies is significantly less than that of galaxies at z < 2 with similar masses, SFRs, and sizes, implying that additional CMQGs must be created in the intervening 1 Gyr between z = 3 and z = 2. We find five star-forming galaxies at z 3 that are compact (Re < 1.4 kpc) and have stellar mass M* > 1010.6M; these galaxies are likely to become members of the massive, quiescent, compact galaxy population at z 2. We evolve the stellar masses and SFRs of each individual z > 3 galaxy adopting five different star formation histories (SFHs) and studying the resulting population of massive galaxies at z = 2.3. We find that declining or truncated SFHs are necessary to match the observed number density of MQGs at z 2, whereas a constant delayed-exponential SFH would result in a number density significantly smaller than observed. All of our assumed SFHs imply number densities of CMQGs at z 2 that are consistent with the observed number density. Better agreement with the observed number density of CMQGs at z 2 is obtained if merging is included in the analysis and better still if star formation quenching is assumed to shortly follow the merging event, as implied by recent models of the formation of MQGs.

The Luminous Polycyclic Aromatic Hydrocarbon Emission Features: Applications to High Redshift Galaxies and Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Shipley, Heath; Papovich, Casey

2015-08-01

We provide a new robust star-formation rate (SFR) calibration using the luminosity from polycyclic aromatic hydrogen (PAH) molecules. The PAH features emit strongly in the mid-infrared (mid-IR; 3-19μm), mitigating dust extinction, and they are very luminous, containing 5-10% of the total IR luminosity in galaxies. We derive the calibration of the PAH luminosity as a SFR indicator using a sample of 105 star-forming galaxies covering a range of total IR luminosity, LIR = L(8-1000μm) = 109 - 1012 L⊙ and redshift 0 < z < 0.6. The PAH luminosity correlates linearly with the SFR as measured by the dust-corrected Hα luminosity (using the sum of the Hα and rest-frame 24μm luminosity from Kennicutt et al. 2009), with tight scatter of ~0.15 dex, comparable to the scatter in the dust-corrected Hα SFRs and Paα SFRs. We show this relation is sensitive to galaxy metallicity, where the PAH luminosity of galaxies with Z < 0.7 Z⊙ departs from the linear SFR relationship but in a behaved manor. We derive for this a correction to galaxies below solar metallicity. As a case study for observations with JWST, we apply the PAH SFR calibration to a sample of lensed galaxies at 1 < z < 3 with Spitzer Infrared Spectrograph (IRS) data, and we demonstrate the utility of PAHs to derive SFRs as accurate as those available from any other indicator. This new SFR indicator will be useful for probing the peak of the SFR density of the universe (1 < z < 3) and for studying the coevolution of star-formation and supermassive blackhole accretion contemporaneously in a galaxy.

STAR FORMATION ACTIVITY IN CLASH BRIGHTEST CLUSTER GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fogarty, Kevin; Postman, Marc; Connor, Thomas

2015-11-10

The CLASH X-ray selected sample of 20 galaxy clusters contains 10 brightest cluster galaxies (BCGs) that exhibit significant (>5σ) extinction-corrected star formation rates (SFRs). Star formation activity is inferred from photometric estimates of UV and Hα+[N ii] emission in knots and filaments detected in CLASH Hubble Space Telescope ACS and WFC3 observations. UV-derived SFRs in these BCGs span two orders of magnitude, including two with a SFR ≳ 100 M{sub ⊙} yr{sup −1}. These measurements are supplemented with [O ii], [O iii], and Hβ fluxes measured from spectra obtained with the SOAR telescope. We confirm that photoionization from ongoing starmore » formation powers the line emission nebulae in these BCGs, although in many BCGs there is also evidence of a LINER-like contribution to the line emission. Coupling these data with Chandra X-ray measurements, we infer that the star formation occurs exclusively in low-entropy cluster cores and exhibits a correlation with gas properties related to cooling. We also perform an in-depth study of the starburst history of the BCG in the cluster RXJ1532.9+3021, and create 2D maps of stellar properties on scales down to ∼350 pc. These maps reveal evidence for an ongoing burst occurring in elongated filaments, generally on ∼0.5–1.0 Gyr timescales, although some filaments are consistent with much younger (≲100 Myr) burst timescales and may be correlated with recent activity from the active galactic nucleus. The relationship between BCG SFRs and the surrounding intracluster medium gas properties provide new support for the process of feedback-regulated cooling in galaxy clusters and is consistent with recent theoretical predictions.« less

The Average Star Formation Histories of Galaxies in Dark Matter Halos from z = 0-8

NASA Astrophysics Data System (ADS)

Behroozi, Peter S.; Wechsler, Risa H.; Conroy, Charlie

2013-06-01

We present a robust method to constrain average galaxy star formation rates (SFRs), star formation histories (SFHs), and the intracluster light (ICL) as a function of halo mass. Our results are consistent with observed galaxy stellar mass functions, specific star formation rates (SSFRs), and cosmic star formation rates (CSFRs) from z = 0 to z = 8. We consider the effects of a wide range of uncertainties on our results, including those affecting stellar masses, SFRs, and the halo mass function at the heart of our analysis. As they are relevant to our method, we also present new calibrations of the dark matter halo mass function, halo mass accretion histories, and halo-subhalo merger rates out to z = 8. We also provide new compilations of CSFRs and SSFRs; more recent measurements are now consistent with the buildup of the cosmic stellar mass density at all redshifts. Implications of our work include: halos near 1012 M ⊙ are the most efficient at forming stars at all redshifts, the baryon conversion efficiency of massive halos drops markedly after z ~ 2.5 (consistent with theories of cold-mode accretion), the ICL for massive galaxies is expected to be significant out to at least z ~ 1-1.5, and dwarf galaxies at low redshifts have higher stellar mass to halo mass ratios than previous expectations and form later than in most theoretical models. Finally, we provide new fitting formulae for SFHs that are more accurate than the standard declining tau model. Our approach places a wide variety of observations relating to the SFH of galaxies into a self-consistent framework based on the modern understanding of structure formation in ΛCDM. Constraints on the stellar mass-halo mass relationship and SFRs are available for download online.

Dust Attenuation and H(alpha) Star Formation Rates of Z Approx. 0.5 Galaxies

NASA Technical Reports Server (NTRS)

Ly, Chun; Malkan, Matthew A.; Kashikawa, Nobunari; Ota, Kazuaki; Shimasaku, Kazuhiro; Iye, Masanori; Currie, Thayne

2012-01-01

Using deep narrow-band and broad-band imaging, we identify 401 z approximately 0.40 and 249 z approximately 0.49 H-alpha line-emitting galaxies in the Subaru Deep Field. Compared to other H-alpha surveys at similar redshifts, our samples are unique since they probe lower H-alpha luminosities, are augmented with multi-wavelength (rest-frame 1000AA--1.5 microns) coverage, and a large fraction (20%) of our samples has already been spectroscopically confirmed. Our spectra allow us to measure the Balmer decrement for nearly 60 galaxies with H-beta detected above 5-sigma. The Balmer decrements indicate an average extinction of A(H-alpha)=0.7(uparrow){+1.4}_{-0.7} mag. We find that the Balmer decrement systematically increases with higher H-alpha luminosities and with larger stellar masses, in agreement with previous studies with sparser samples. We find that the SFRs estimated from modeling the spectral energy distribution (SED) is reliable---we derived an "intrinsic" H-alpha luminosity which is then reddened assuming the color excess from SED modeling. The SED-predicted H-alpha luminosity agrees with H-alpha narrow-band measurements over 3 dex (rms of 0.25 dex). We then use the SED SFRs to test different statistically-based dust corrections for H-alpha and find that adopting one magnitude of extinction is inappropriate: galaxies with lower luminosities are less reddened. We find that the luminosity-dependent dust correction of Hopkins et al. yields consistent results over 3 dex (rms of 0.3 dex). Our comparisons are only possible by assuming that stellar reddening is roughly half of nebular reddening. The strong correspondence argue that with SED modeling, we can derive reliable intrinsic SFRs even in the absence of H-alpha measurements at z approximately 0.5.

Are star formation rates of galaxies bimodal?

NASA Astrophysics Data System (ADS)

Feldmann, Robert

2017-09-01

Star formation rate (SFR) distributions of galaxies are often assumed to be bimodal with modes corresponding to star-forming and quiescent galaxies, respectively. Both classes of galaxies are typically studied separately, and SFR distributions of star-forming galaxies are commonly modelled as lognormals. Using both observational data and results from numerical simulations, I argue that this division into star-forming and quiescent galaxies is unnecessary from a theoretical point of view and that the SFR distributions of the whole population can be well fitted by zero-inflated negative binomial distributions. This family of distributions has three parameters that determine the average SFR of the galaxies in the sample, the scatter relative to the star-forming sequence and the fraction of galaxies with zero SFRs, respectively. The proposed distributions naturally account for (I) the discrete nature of star formation, (II) the presence of 'dead' galaxies with zero SFRs and (III) asymmetric scatter. Excluding 'dead' galaxies, the distribution of log SFR is unimodal with a peak at the star-forming sequence and an extended tail towards low SFRs. However, uncertainties and biases in the SFR measurements can create the appearance of a bimodal distribution.

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.

PubMed

Chen, Shasha; Cai, Chenxu; Li, Zehua; Liu, Guangao; Wang, Yuande; Blonska, Marzenna; Li, Dan; Du, Juan; Lin, Xin; Yang, Meixiang; Dong, Zhongjun

2017-02-01

Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) mutations in X-linked lymphoproliferative disease (XLP) lead to defective NKT cell development and impaired humoral immunity. Because of the redundancy of SLAM family receptors (SFRs) and the complexity of SAP actions, how SFRs and SAP mediate these processes remains elusive. Here, we examined NKT cell development and humoral immunity in mice completely deficient in SFR. We found that SFR deficiency severely impaired NKT cell development. In contrast to SAP deficiency, SFR deficiency caused no apparent defect in follicular helper T (T FH ) cell differentiation. Intriguingly, the deletion of SFRs completely rescued the severe defect in T FH cell generation caused by SAP deficiency, whereas SFR deletion had a minimal effect on the defective NKT cell development in SAP-deficient mice. These findings suggest that SAP-dependent activating SFR signaling is essential for NKT cell selection; however, SFR signaling is inhibitory in SAP-deficient T FH cells. Thus, our current study revises our understanding of the mechanisms underlying T cell defects in patients with XLP. © 2017 Chen et al.

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity

PubMed Central

Cai, Chenxu; Liu, Guangao; Wang, Yuande; Du, Juan; Lin, Xin; Yang, Meixiang

2017-01-01

Signaling lymphocytic activation molecule (SLAM)–associated protein (SAP) mutations in X-linked lymphoproliferative disease (XLP) lead to defective NKT cell development and impaired humoral immunity. Because of the redundancy of SLAM family receptors (SFRs) and the complexity of SAP actions, how SFRs and SAP mediate these processes remains elusive. Here, we examined NKT cell development and humoral immunity in mice completely deficient in SFR. We found that SFR deficiency severely impaired NKT cell development. In contrast to SAP deficiency, SFR deficiency caused no apparent defect in follicular helper T (TFH) cell differentiation. Intriguingly, the deletion of SFRs completely rescued the severe defect in TFH cell generation caused by SAP deficiency, whereas SFR deletion had a minimal effect on the defective NKT cell development in SAP-deficient mice. These findings suggest that SAP-dependent activating SFR signaling is essential for NKT cell selection; however, SFR signaling is inhibitory in SAP-deficient TFH cells. Thus, our current study revises our understanding of the mechanisms underlying T cell defects in patients with XLP. PMID:28049627

Galaxy pairs in the SDSS - XIII. The connection between enhanced star formation and molecular gas properties in galaxy mergers

NASA Astrophysics Data System (ADS)

Violino, Giulio; Ellison, Sara L.; Sargent, Mark; Coppin, Kristen E. K.; Scudder, Jillian M.; Mendel, Trevor J.; Saintonge, Amelie

2018-05-01

We investigate the connection between star formation and molecular gas properties in galaxy mergers at low redshift (z ≤ 0.06). The study we present is based on IRAM 30-m CO(1-0) observations of 11 galaxies with a close companion selected from the Sloan Digital Sky Survey (SDSS). The pairs have mass ratios ≤4, projected separations rp ≤ 30 kpc and velocity separations ΔV ≤ 300 km s-1, and have been selected to exhibit enhanced specific star formation rates (sSFRs). We calculate molecular gas (H2) masses, assigning to each galaxy a physically motivated conversion factor αCO, and we derive molecular gas fractions and depletion times. We compare these quantities with those of isolated galaxies from the extended CO Legacy Data base for the GALEX Arecibo SDSS Survey sample (xCOLDGASS; Saintonge et al.) with gas quantities computed in an identical way. Ours is the first study which directly compares the gas properties of galaxy pairs and those of a control sample of normal galaxies with rigorous control procedures and for which SFR and H2 masses have been estimated using the same method. We find that the galaxy pairs have shorter depletion times and an average molecular gas fraction enhancement of 0.4 dex compared to the mass matched control sample drawn from xCOLDGASS. However, the gas masses (and fractions) in galaxy pairs and their depletion times are consistent with those of non-mergers whose SFRs are similarly elevated. We conclude that both external interactions and internal processes may lead to molecular gas enhancement and decreased depletion times.

The Role Of Rejuvenation In Shaping The High-Mass End Of The Main Sequence

NASA Astrophysics Data System (ADS)

Mancini, Chiara

2017-06-01

We investigate the nature of star forming galaxies with reduced specific SFRs and high stellar masses, those that seemingly cause the so-called bending of the main sequence. The fact that such objects host large bulges recently lead some to suggest that the internal formation of the bulges, via compaction or disk instabilities, was the late event that induced sSFRs of massive galaxies to drop in a slow downfall and thus the main sequence to bend. We have studied in detail a sample of 16 galaxies at 0.5

A COMPARATIVE STUDY OF KNOTS OF STAR FORMATION IN INTERACTING VERSUS SPIRAL GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Beverly J.; Olmsted, Susan; Jones, Keith

2016-03-15

Interacting galaxies are known to have higher global rates of star formation on average than normal galaxies, relative to their stellar masses. Using UV and IR photometry combined with new and published Hα images, we have compared the star formation rates (SFRs) of ∼700 star forming complexes in 46 nearby interacting galaxy pairs with those of regions in 39 normal spiral galaxies. The interacting galaxies have proportionally more regions with high SFRs than the spirals. The most extreme regions in the interacting systems lie at the intersections of spiral/tidal structures, where gas is expected to pile up and trigger starmore » formation. Published Hubble Space Telescope images show unusually large and luminous star clusters in the highest luminosity regions. The SFRs of the clumps correlate with measures of the dust attenuation, consistent with the idea that regions with more interstellar gas have more star formation. For the clumps with the highest SFRs, the apparent dust attenuation is consistent with the Calzetti starburst dust attenuation law. This suggests that the high luminosity regions are dominated by a central group of young stars surrounded by a shell of clumpy interstellar gas. In contrast, the lower luminosity clumps are bright in the UV relative to Hα, suggesting either a high differential attenuation between the ionized gas and the stars, or a post-starburst population bright in the UV but faded in Hα. The fraction of the global light of the galaxies in the clumps is higher on average for the interacting galaxies than for the spirals. Thus either star formation in interacting galaxies is “clumpier” on average, or the star forming regions in interacting galaxies are more luminous, dustier, or younger on average.« less

Asteroid spin-rate studies using large sky-field surveys

NASA Astrophysics Data System (ADS)

Chang, Chan-Kao; Lin, Hsing-Wen; Ip, Wing-Huen; Prince, Thomas A.; Kulkarni, Shrinivas R.; Levitan, David; Laher, Russ; Surace, Jason

2017-12-01

Eight campaigns to survey asteroid rotation periods have been carried out using the intermediate Palomar Transient Factory in the past 3 years. 2780 reliable rotation periods were obtained, from which we identified two new super-fast rotators (SFRs), (335433) 2005 UW163 and (40511) 1999 RE88, and 23 candidate SFRs. Along with other three known super-fast rotators, there are five known SFRs so far. Contrary to the case of rubble-pile asteroids (i.e., bounded aggregations by gravity only), an internal cohesion, ranging from 100 to 1000 Pa, is required to prevent these five SFRs from flying apart because of their super-fast rotations. This cohesion range is comparable with that of lunar regolith. However, some candidates of several kilometers in size require unusually high cohesion (i.e., a few thousands of Pa). Therefore, the confirmation of these kilometer-sized candidates can provide important information about asteroid interior structure. From the rotation periods we collected, we also found that the spin-rate limit of C-type asteroids, which has a lower bulk density, is lower than for S-type asteroids. This result is in agreement with the general picture of rubble-pile asteroids (i.e., lower bulk density, lower spin-rate limit). Moreover, the spin-rate distributions of asteroids of 3< D < 15 km in size show a steady decrease along frequency for f > 5 rev/day, regardless of the location in the main belt. The YORP effect is indicated to be less efficient in altering asteroid spin rates from our results when compared with the flat distribution found by Pravec et al. (Icarus 197:497-504, 2008. doi: 10.1016/j.icarus.2008.05.012). We also found a significant number drop at f = 5 rev/day in the spin-rate distributions of asteroids of D < 3 km.

The Effect of Star Formation History on the Inferred Stellar Initial Mass Function

NASA Astrophysics Data System (ADS)

Elmegreen, Bruce G.; Scalo, John

2006-01-01

Peaks and lulls in the star formation rate (SFR) over the history of the Galaxy produce plateaus and declines in the present-day mass function (PDMF) where the main-sequence lifetime overlaps the age and duration of the SFR variation. These PDMF features can be misinterpreted as the form of the intrinsic stellar initial mass function (IMF) if the star formation rate is assumed to be constant or slowly varying with time. This effect applies to all regions that have formed stars for longer than the age of the most massive stars, including OB associations, star complexes, and especially galactic field stars. Related problems may apply to embedded clusters. Evidence is summarized for temporal SFR variations from parsec scales to entire galaxies, all of which should contribute to inferred IMF distortions. We give examples of various star formation histories to demonstrate the types of false IMF structures that might be seen. These include short-duration bursts, stochastic histories with lognormal amplitude distributions, and oscillating histories with various periods and phases. The inferred IMF should appear steeper than the intrinsic IMF over mass ranges where the stellar lifetimes correspond to times of decreasing SFRs; shallow portions of the inferred IMF correspond to times of increasing SFRs. If field regions are populated by dispersed clusters and defined by their low current SFRs, then they should have steeper inferred IMFs than the clusters. The SFRs required to give the steep field IMFs in the LMC and SMC are determined. Structure observed in several determinations of the Milky Way field star IMF can be accounted for by a stochastic and bursty star formation history.

VizieR Online Data Catalog: X-ray observations of HCG galaxies (Tzanavaris+, 2016)

NASA Astrophysics Data System (ADS)

Tzanavaris, P.; Hornschemeier, A. E.; Gallagher, S. C.; Lenkic, L.; Desjardins, T. D.; Walker, L. M.; Johnson, K. E.; Mulchaey, J. S.

2016-04-01

In this paper we study a sample of 15 compact groups (CGs) observed with Chandra/ACIS, Swift/UVOT and Spitzer/IRAC-MIPS for which archival data exist, allowing us to obtain SFRs, stellar masses, sSFRs and X-ray fluxes and luminosities. Table 1 shows the group sample, including redshifts, luminosity distances and group evolutionary types. Allowing for the fact that some galaxies do not fall in the field of view of all three instruments, the total number of CG galaxies analyzed is 47. Details on the Swift and Spitzer observations and data for systems in this sample can be found in Tzanavaris et al. (2010ApJ...716..556T) and (L. Lenkic et al. 2015, in preparation). For Chandra/ACIS observations we refer the reader to Tzanavaris et al. (2014, J/ApJS/212/9) and Desjardins et al. (2013ApJ...763..121D; 2014ApJ...790..132D). (2 data files).

The ALMA Spectroscopic Survey in the Hubble Ultra Deep Field: Continuum Number Counts, Resolved 1.2 mm Extragalactic Background, and Properties of the Faintest Dusty Star-forming Galaxies

NASA Astrophysics Data System (ADS)

Aravena, M.; Decarli, R.; Walter, F.; Da Cunha, E.; Bauer, F. E.; Carilli, C. L.; Daddi, E.; Elbaz, D.; Ivison, R. J.; Riechers, D. A.; Smail, I.; Swinbank, A. M.; Weiss, A.; Anguita, T.; Assef, R. J.; Bell, E.; Bertoldi, F.; Bacon, R.; Bouwens, R.; Cortes, P.; Cox, P.; Gónzalez-López, J.; Hodge, J.; Ibar, E.; Inami, H.; Infante, L.; Karim, A.; Le Le Fèvre, O.; Magnelli, B.; Ota, K.; Popping, G.; Sheth, K.; van der Werf, P.; Wagg, J.

2016-12-01

We present an analysis of a deep (1σ = 13 μJy) cosmological 1.2 mm continuum map based on ASPECS, the ALMA Spectroscopic Survey in the Hubble Ultra Deep Field. In the 1 arcmin2 covered by ASPECS we detect nine sources at \\gt 3.5σ significance at 1.2 mm. Our ALMA-selected sample has a median redshift of z=1.6+/- 0.4, with only one galaxy detected at z > 2 within the survey area. This value is significantly lower than that found in millimeter samples selected at a higher flux density cutoff and similar frequencies. Most galaxies have specific star formation rates (SFRs) similar to that of main-sequence galaxies at the same epoch, and we find median values of stellar mass and SFRs of 4.0× {10}10 {M}⊙ and ˜ 40 {M}⊙ yr-1, respectively. Using the dust emission as a tracer for the interstellar medium (ISM) mass, we derive depletion times that are typically longer than 300 Myr, and we find molecular gas fractions ranging from ˜0.1 to 1.0. As noted by previous studies, these values are lower than those using CO-based ISM estimates by a factor of ˜2. The 1 mm number counts (corrected for fidelity and completeness) are in agreement with previous studies that were typically restricted to brighter sources. With our individual detections only, we recover 55% ± 4% of the extragalactic background light (EBL) at 1.2 mm measured by the Planck satellite, and we recover 80% ± 7% of this EBL if we include the bright end of the number counts and additional detections from stacking. The stacked contribution is dominated by galaxies at z˜ 1{--}2, with stellar masses of (1-3) × 1010 M {}⊙ . For the first time, we are able to characterize the population of galaxies that dominate the EBL at 1.2 mm.

Star-formation rate in compact star-forming galaxies

NASA Astrophysics Data System (ADS)

Izotova, I. Y.; Izotov, Y. I.

2018-03-01

We use the data for the Hβ emission-line, far-ultraviolet (FUV) and mid-infrared 22 μm continuum luminosities to estimate star formation rates < SFR > averaged over the galaxy lifetime for a sample of about 14000 bursting compact star-forming galaxies (CSFGs) selected from the Data Release 12 (DR12) of the Sloan Digital Sky Survey (SDSS). The average coefficient linking < SFR > and the star formation rate SFR0 derived from the Hβ luminosity at zero starburst age is found to be 0.04. We compare < SFR > s with some commonly used SFRs which are derived adopting a continuous star formation during a period of {˜} 100 Myr, and find that the latter ones are 2-3 times higher. It is shown that the relations between SFRs derived using a geometric mean of two star-formation indicators in the UV and IR ranges and reduced to zero starburst age have considerably lower dispersion compared to those with single star-formation indicators. We suggest that our relations for < SFR > determination are more appropriate for CSFGs because they take into account a proper temporal evolution of their luminosities. On the other hand, we show that commonly used SFR relations can be applied for approximate estimation within a factor of {˜} 2 of the < SFR > averaged over the lifetime of the bursting compact galaxy.

The Large Super-Fast Rotators and Asteroidal Spin-Rate Distributions With Large Sky-Field Surveys Using iPTF

NASA Astrophysics Data System (ADS)

Chang, Chan-Kao; Lin, Hsing-Wen; Ip, Wing-Huen; iPTF Team

2016-10-01

In order to look for kilometer-sized super-fast rotators (large SFRs) and understand the spin-rate distributions of small (i.e. D of several kilometers) asteroids, we have been conducting asteroid rotation period surveys of large sky area using intermediate Palomar Transient Factory (iPTF) since 2014. So far, we have observed 261 deg2 with 20 min cadence, 188 deg2 with 10 min cadence, and 65 deg2 with 5 min cadence. From these surveys, we found that the spin-rate distributions of small asteroids at different locations in the main-belt are very similar. Moreover, the distributions of asteroids with 3 < D < 15 km show number decrease along with increase of spin rate for frequency > 5 rev/day, and that of asteroids with D < 3 km have a significant number drop at frequency = 5 rev/day. However, we only discover two new large SFRs and 24 candidates. Comparing with the ordinary asteroids, the population of large SFR seems to be far less than the whole asteroid population. This might indicate a peculiar group of asteroid for large SFRs.

Investigating the Lyman photon escape in local starburst galaxies with the Cosmic Origins Spectrograph ★

NASA Astrophysics Data System (ADS)

Hernandez, Svea; Leitherer, Claus; Boquien, Médéric; Buat, Véronique; Burgarella, Denis; Calzetti, Daniela; Noll, Stefan

2018-04-01

We present a study of 7 star-forming galaxies from the Cosmic Evolution Survey (COSMOS) observed with the Cosmic Origins Spectrograph (COS) on board the Hubble Space Telescope (HST). The galaxies are located at relatively low redshifts, z ˜0.3, with morphologies ranging from extended and disturbed to compact and smooth. To complement the HST observations we also analyze observations taken with the VIMOS spectrograph on the Very Large Telescope (VLT). In our galaxy sample we identify three objects with double peak Lyman-α profiles similar to those seen in Green Pea compact galaxies and measure peak separations of 655, 374, and 275 km s-1. We measure Lyman-α escape fractions with values ranging between 5-13%. Given the low flux levels in the individual COS exposures we apply a weighted stacking approach to obtain a single spectrum. From this COS combined spectrum we infer upper limits for the absolute and relative Lyman continuum escape fractions of f_abs(LyC) = 0.4^{+10.1}_{-0.4}% and f_res(LyC) = 1.7^{+15.2}_{-1.7}%, respectively. Finally, we find that most of these galaxies have moderate UV and optical SFRs (SFRs ≲ 10 M⊙ yr-1).

Investigating the Lyman photon escape in local starburst galaxies with the Cosmic Origins Spectrograph

NASA Astrophysics Data System (ADS)

Hernandez, Svea; Leitherer, Claus; Boquien, Médéric; Buat, Véronique; Burgarella, Denis; Calzetti, Daniela; Noll, Stefan

2018-07-01

We present a study of seven star-forming galaxies from the Cosmic Evolution Survey observed with the Cosmic Origins Spectrograph (COS) onboard the Hubble Space Telescope (HST). The galaxies are located at relatively low redshifts, z ˜ 0.3, with morphologies ranging from extended and disturbed to compact and smooth. To complement the HST observations, we also analyse observations taken with the Visible Multi-object Spectrograph (VIMOS) on the Very Large Telescope (VLT). In our galaxy sample, we identify three objects with double peak Lyman-α profiles similar to those seen in Green Pea compact galaxies and measure peak separations of 655, 374, and 275 km s-1. We measure Lyman-α escape fractions with values ranging between 5 per cent and 13 per cent. Given the low flux levels in the individual COS exposures, we apply a weighted stacking approach to obtain a single spectrum. From this COS combined spectrum, we infer upper limits for the absolute and relative Lyman continuum escape fractions of f_abs(LyC) = 0.4^{+10.1}_{-0.4} per cent and f_res(LyC) = 1.7^{+15.2}_{-1.7}per cent, respectively. Finally, we find that most of these galaxies have moderate ultraviolet and optical star formation rates (SFRs) (SFRs ≲10 M⊙ yr-1).

A Critical Assessment of Ages Derived Using Pre-Main-Sequence Isochrones in Colour-Magnitude Diagrams

NASA Astrophysics Data System (ADS)

Bell, Cameron P. M.

2012-11-01

In this thesis a critical assessment of the ages derived using theoretical pre-main-sequence (pre-MS) stellar evolutionary models is presented by comparing the predictions to the low-mass pre-MS population of 14 young star-forming regions (SFRs) in colour-magnitude diagrams (CMDs). Deriving pre-MS ages requires precise distances and estimates of the reddening. Therefore, the main-sequence (MS) members of the SFRs have been used to derive a self-consistent set of statistically robust ages, distances and reddenings with associated uncertainties using a maximum-likelihood fitting statistic and MS evolutionary models. A photometric method for de-reddening individual stars - known as the Q-method - in regions where the extinction is spatially variable has been updated and is presented. The effects of both the model dependency and the SFR composition on these derived parameters are also discussed. The problem of calibrating photometric observations of red pre-MS stars is examined and it is shown that using observations of MS stars to transform the data into a standard photometric system can introduce significant errors in the position of the pre-MS locus in CMD space. Hence, it is crucial that precise photometric studies - especially of pre-MS objects - be carried out in the natural photometric system of the observations. This therefore requires a robust model of the system responses for the instrument used, and thus the calculated responses for the Wide-Field Camera on the Isaac Newton Telescope are presented. These system responses have been tested using standard star observations and have been shown to be a good representation of the photometric system. A benchmark test for the pre-MS evolutionary models is performed by comparing them to a set of well-calibrated CMDs of the Pleiades in the wavelength regime 0.4-2.5 μm. The masses predicted by these models are also tested against dynamical masses using a sample of MS binaries by calculating the system magnitude in a given photometric bandpass. This analysis shows that for Teff ≤ 4000 K the models systematically overestimate the flux by a factor of 2 at 0.5 μm, though this decreases with wavelength, becoming negligible at 2.2 μm. Thus before the pre-MS models are used to derive ages, a recalibration of the models is performed by incorporating an empirical colour-Teff relation and bolometric corrections based on the Ks-band luminosity of Pleiades members, with theoretical corrections for the dependence on the surface gravity (log g). The recalibrated pre-MS model isochrones are used to derive ages from the pre-MS populations of the SFRs. These ages are then compared with the MS derivations, thus providing a powerful diagnostic tool with which to discriminate between the different pre-MS age scales that arise from a much stronger model dependency in the pre-MS regime. The revised ages assigned to each of the 14 SFRs are up to a factor two older than previous derivations, a result with wide-ranging implications, including that circumstellar discs survive longer and that the average Class II lifetime is greater than currently believed.

Knowledge of stroke risk factors and early warning signs of stroke among students enrolled in allied health programs: a pilot study.

PubMed

Milner, Abby; Lewis, William J; Ellis, Charles

2008-01-01

The inclusion of stroke education modules early in medical school curricula has resulted in improved stroke knowledge in graduate physicians. The success of these programs suggests that allied health professions programs should also consider strategies to improve stroke knowledge in students preparing for allied health careers that also require knowledge of stroke risk factors and early warning signs. Currently, little is known about stroke knowledge in students enrolled in allied health professions programs. 208 first- and second-year students enrolled in allied health programs completed a survey of stroke risk factors and early warning signs of stroke. Risk factor knowledge - 99% identified smoking as a risk factor; 67% identified diabetes; 93% identified high cholesterol; 89% identified age; and 92% identified physical inactivity. Less than 50% of the students identified all 5 risk factors. There were no differences between first- and second-year students in risk factor knowledge. Early warning signs and first response knowledge - 89% recognized sudden confusion or trouble speaking; 94% recognized sudden facial, arm, or leg weakness; 65% recognized sudden vision loss; 82% recognized sudden trouble walking; and 73% recognized sudden headache as early warning signs of stroke. Eighty-one percent recognized calling 9-1-1 as the appropriate first action. However, only 25% recognized all five early warning signs and only 20% recognized all five early warning signs and would call 9-1-1 as the first action. There were differences between first- and second-year students in recognizing 3 of 5 early warning signs and appropriate first action to call 9-1-1. Most students recognized individual stroke risk factors and early warning signs but few recognized multiple risk factors and early warning signs of stroke.

Star Formation Activity in CLASH Brightest Cluster Galaxies

NASA Astrophysics Data System (ADS)

Fogarty, Kevin; Postman, Marc; Connor, Thomas; Donahue, Megan; Moustakas, John

2015-11-01

The CLASH X-ray selected sample of 20 galaxy clusters contains 10 brightest cluster galaxies (BCGs) that exhibit significant (>5σ) extinction-corrected star formation rates (SFRs). Star formation activity is inferred from photometric estimates of UV and Hα+[N ii] emission in knots and filaments detected in CLASH Hubble Space Telescope ACS and WFC3 observations. UV-derived SFRs in these BCGs span two orders of magnitude, including two with a SFR ≳ 100 M⊙ yr-1. These measurements are supplemented with [O ii], [O iii], and Hβ fluxes measured from spectra obtained with the SOAR telescope. We confirm that photoionization from ongoing star formation powers the line emission nebulae in these BCGs, although in many BCGs there is also evidence of a LINER-like contribution to the line emission. Coupling these data with Chandra X-ray measurements, we infer that the star formation occurs exclusively in low-entropy cluster cores and exhibits a correlation with gas properties related to cooling. We also perform an in-depth study of the starburst history of the BCG in the cluster RXJ1532.9+3021, and create 2D maps of stellar properties on scales down to ˜350 pc. These maps reveal evidence for an ongoing burst occurring in elongated filaments, generally on ˜0.5-1.0 Gyr timescales, although some filaments are consistent with much younger (≲100 Myr) burst timescales and may be correlated with recent activity from the active galactic nucleus. The relationship between BCG SFRs and the surrounding intracluster medium gas properties provide new support for the process of feedback-regulated cooling in galaxy clusters and is consistent with recent theoretical predictions. Based on observations obtained at the Southern Astrophysical Research (SOAR) telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the U.S. National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

VLBA SURVEYS OF OH MASERS IN STAR-FORMING REGIONS. I. SATELLITE LINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruiz-Velasco, A. E.; Felli, D.; Migenes, V.

2016-05-10

Using the Very Long Baseline Array we performed a high-resolution OH maser survey in Galactic star-forming regions (SFRs). We observed all the ground state spectral lines: the main lines at 1665 and 1667 MHz and the satellite lines at 1612 and 1720 MHz. Due to the exceptionality of finding satellite lines in SFRs, we will focus our discussion on those lines. In our sample of 41 OH maser sources, five (12%) showed the 1612 MHz line and ten (24%) showed the 1720 MHz line, with only one source showing both lines. We find that 1720 MHz emission is correlated withmore » the presence of H ii regions, suggesting that this emission could be used to diagnose or trace high-mass star formation. We include an analysis of the possible mechanisms that could be causing this correlation as well as assessing the possible relationships between lines in our sample. In particular, the presence of magnetic fields seems to play an important role as we found Zeeman splitting in four of our sources (W75 N, W3(OH), W51 and NGC 7538). Our results have implications for current understanding of the formation of high-mass stars as well as on the masing processes present in SFRs.« less

HIGH STAR FORMATION RATES IN TURBULENT ATOMIC-DOMINATED GAS IN THE INTERACTING GALAXIES IC 2163 AND NGC 2207

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elmegreen, Bruce G.; Kaufman, Michele; Bournaud, Frédéric

CO observations of the interacting galaxies IC 2163 and NGC 2207 are combined with HI, H α , and 24 μ m observations to study the star formation rate (SFR) surface density as a function of the gas surface density. More than half of the high-SFR regions are HI dominated. When compared to other galaxies, these HI-dominated regions have excess SFRs relative to their molecular gas surface densities but normal SFRs relative to their total gas surface densities. The HI-dominated regions are mostly located in the outer part of NGC 2207 where the HI velocity dispersion is high, 40–50 kmmore » s{sup −1}. We suggest that the star-forming clouds in these regions have envelopes at lower densities than normal, making them predominantly atomic, and cores at higher densities than normal because of the high turbulent Mach numbers. This is consistent with theoretical predictions of a flattening in the density probability distribution function for compressive, high Mach number turbulence.« less

Significant Enhancement of H2 Formation in Disk Galaxies under Strong Ram Pressure

NASA Astrophysics Data System (ADS)

Henderson, Benjamin; Bekki, Kenji

2016-05-01

We show for the first time that H2 formation on dust grains can be enhanced in disk galaxies under strong ram pressure (RP). We numerically investigate how the time evolution of H I and H2 components in disk galaxies orbiting a group/cluster of galaxies can be influenced by the hydrodynamical interaction between the gaseous components of the galaxies and the hot intracluster medium. We find that compression of H I caused by RP increases H2 formation in disk galaxies before RP rapidly strips H I, cutting off the fuel supply and causing a drop in H2 density. We also find that the level of this H2 formation enhancement in a disk galaxy under RP depends on the mass of its host cluster dark matter halo, the initial positions and velocities of the disk galaxy, and the disk inclination angle with respect to the orbital plane. We demonstrate that dust growth is a key factor in the evolution of the H I and H2 mass in disk galaxies under strong RP. We discuss how the correlation between H2 fractions and surface gas densities of disk galaxies evolves with time in the galaxies under RP. We also discuss whether galaxy-wide star formation rates (SFRs) in cluster disk galaxies can be enhanced by RP if the SFRs depend on H2 densities.

An Innovative Hybrid Loop-Pool SFR Design and Safety Analysis Methods: Today and Tomorrow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hongbin Zhang; Haihua Zhao; Vincent Mousseau

2008-04-01

Investment in commercial sodium cooled fast reactor (SFR) power plants will become possible only if SFRs achieve economic competitiveness as compared to light water reactors and other Generation IV reactors. Toward that end, we have launched efforts to improve the economics and safety of SFRs from the thermal design and safety analyses perspectives at Idaho National Laboratory. From the thermal design perspective, an innovative hybrid loop-pool SFR design has been proposed. This design takes advantage of the inherent safety of a pool design and the compactness of a loop design to further improve economics and safety. From the safety analysesmore » perspective, we have initiated an effort to develop a high fidelity reactor system safety code.« less

Measures of star formation rates from infrared (Herschel) and UV (GALEX) emissions of galaxies in the HerMES fields

NASA Astrophysics Data System (ADS)

Buat, V.; Giovannoli, E.; Burgarella, D.; Altieri, B.; Amblard, A.; Arumugam, V.; Aussel, H.; Babbedge, T.; Blain, A.; Bock, J.; Boselli, A.; Castro-Rodríguez, N.; Cava, A.; Chanial, P.; Clements, D. L.; Conley, A.; Conversi, L.; Cooray, A.; Dowell, C. D.; Dwek, E.; Eales, S.; Elbaz, D.; Fox, M.; Franceschini, A.; Gear, W.; Glenn, J.; Griffin, M.; Halpern, M.; Hatziminaoglou, E.; Heinis, S.; Ibar, E.; Isaak, K.; Ivison, R. J.; Lagache, G.; Levenson, L.; Lonsdale, C. J.; Lu, N.; Madden, S.; Maffei, B.; Magdis, G.; Mainetti, G.; Marchetti, L.; Morrison, G. E.; Nguyen, H. T.; O'Halloran, B.; Oliver, S. J.; Omont, A.; Owen, F. N.; Page, M. J.; Pannella, M.; Panuzzo, P.; Papageorgiou, A.; Pearson, C. P.; Pérez-Fournon, I.; Pohlen, M.; Rigopoulou, D.; Rizzo, D.; Roseboom, I. G.; Rowan-Robinson, M.; Sánchez Portal, M.; Schulz, B.; Seymour, N.; Shupe, D. L.; Smith, A. J.; Stevens, J. A.; Strazzullo, V.; Symeonidis, M.; Trichas, M.; Tugwell, K. E.; Vaccari, M.; Valiante, E.; Valtchanov, I.; Vigroux, L.; Wang, L.; Ward, R.; Wright, G.; Xu, C. K.; Zemcov, M.

2010-11-01

The reliability of infrared (IR) and ultraviolet (UV) emissions to measure star formation rates (SFRs) in galaxies is investigated for a large sample of galaxies observed with the Spectral and Photometric Imaging Receiver (SPIRE) and the Photodetector Array Camera and Spectrometer (PACS) instruments on Herschel as part of the Herschel Multi-Tiered Extragalactic Survey (HerMES) project. We build flux-limited 250-μm samples of sources at redshift z < 1, cross-matched with the Spitzer/MIPS and GALEX catalogues. About 60 per cent of the Herschel sources are detected in UV. The total IR luminosities, LIR, of the sources are estimated using a spectral energy distribution (SED) fitting code that fits to fluxes between 24 and 500 μm. Dust attenuation is discussed on the basis of commonly used diagnostics: the LIR/LUV ratio and the slope, β, of the UV continuum. A mean dust attenuation AUV of mag is measured in the samples. LIR/LUV is found to correlate with LIR. Galaxies with and 0.5 < z < 1 exhibit a mean dust attenuation AUV of about 0.7 mag lower than that found for their local counterparts, although with a large dispersion. Our galaxy samples span a large range of β and LIR/LUV values which, for the most part, are distributed between the ranges defined by the relations found locally for starburst and normal star-forming galaxies. As a consequence the recipe commonly applied to local starbursts is found to overestimate the dust attenuation correction in our galaxy sample by a factor of ~2-3. The SFRs deduced from LIR are found to account for about 90 per cent of the total SFR; this percentage drops to 71 per cent for galaxies with (or ). For these faint objects, one needs to combine UV and IR emissions to obtain an accurate measure of the SFR.

Is There a Maximum Star Formation Rate in High-redshift Galaxies?

NASA Astrophysics Data System (ADS)

Barger, A. J.; Cowie, L. L.; Chen, C.-C.; Owen, F. N.; Wang, W.-H.; Casey, C. M.; Lee, N.; Sanders, D. B.; Williams, J. P.

2014-03-01

We use the James Clerk Maxwell Telescope's SCUBA-2 camera to image a 400 arcmin2 area surrounding the GOODS-N field. The 850 μm rms noise ranges from a value of 0.49 mJy in the central region to 3.5 mJy at the outside edge. From these data, we construct an 850 μm source catalog to 2 mJy containing 49 sources detected above the 4σ level. We use an ultradeep (11.5 μJy at 5σ) 1.4 GHz image obtained with the Karl G. Jansky Very Large Array together with observations made with the Submillimeter Array to identify counterparts to the submillimeter galaxies. For most cases of multiple radio counterparts, we can identify the correct counterpart from new and existing Submillimeter Array data. We have spectroscopic redshifts for 62% of the radio sources in the 9' radius highest sensitivity region (556/894) and 67% of the radio sources in the GOODS-N region (367/543). We supplement these with a modest number of additional photometric redshifts in the GOODS-N region (30). We measure millimetric redshifts from the radio to submillimeter flux ratios for the unidentified submillimeter sample, assuming an Arp 220 spectral energy distribution. We find a radio-flux-dependent K - z relation for the radio sources, which we use to estimate redshifts for the remaining radio sources. We determine the star formation rates (SFRs) of the submillimeter sources based on their radio powers and their submillimeter fluxes and find that they agree well. The radio data are deep enough to detect star-forming galaxies with SFRs >2000 M ⊙ yr-1 to z ~ 6. We find galaxies with SFRs up to ~6000 M ⊙ yr-1 over the redshift range z = 1.5-6, but we see evidence for a turn-down in the SFR distribution function above 2000 M ⊙ yr-1. The James Clerk Maxwell Telescope is operated by the Joint Astronomy Centre on behalf of the Science and Technology Facilities Council of the United Kingdom, the National Research Council of Canada, and (until 2013 March 31) the Netherlands Organisation for Scientific Research. The W. M. Keck Observatory is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA, and was made possible by the generous financial support of the W. M. Keck Foundation.

A large-scale structure traced by [O II] emitters hosting a distant cluster at z= 1.62

NASA Astrophysics Data System (ADS)

Tadaki, Ken-ichi; Kodama, Tadayuki; Ota, Kazuaki; Hayashi, Masao; Koyama, Yusei; Papovich, Casey; Brodwin, Mark; Tanaka, Masayuki; Iye, Masanori

2012-07-01

We present a panoramic narrow-band imaging survey of [O II] emitters in and around the ClG J0218.3-0510 cluster at z= 1.62 with Suprime-Cam on Subaru Telescope. 352 [O II] emitters were identified on the basis of narrow-band excesses and photometric redshifts. We discovered a huge filamentary structure with some clumps traced by [O II] emitters and found that the ClG J0218.3-0510 cluster is embedded in an even larger superstructure than the one reported previously. 31 [O II] emitters were spectroscopically confirmed with the detection of Hα and/or [O III] emission lines by Fibre Multi Object Spectrograph observations. In the high-density regions such as cluster core and clumps, star-forming [O II] emitters show a high overdensity by a factor of more than 10 compared to the field region. Interestingly, the relative fraction of [O II] emitters in photo-z selected sample does not depend significantly on the local density. Although the star formation activity is very high even in the cluster core, some massive quiescent galaxies also exist at the same time. Furthermore, the properties of the individual [O II] emitters, such as star formation rates (SFRs), stellar masses and specific SFRs, do not show a significant dependence on the local density, either. Such a lack of environmental dependence is consistent with our earlier result by Hayashi et al. on a z= 1.5 cluster and its surrounding region. The fact that the star-forming activity of galaxies in the cluster core is as high as that in the field at z˜ 1.6 may suggest that the star-forming galaxies are probably just in a transition phase from a starburst mode to a quiescent mode, and are thus showing comparable level of star formation rates to those in lower density environments. We may be witnessing the start of the reversal of the local SFR-density relation due to the 'biased' galaxy formation and evolution in high-density regions at this high redshift, beyond which massive galaxies would be forming vigorously in a more biased way in protocluster cores.

Superluminous Spiral Galaxies

NASA Astrophysics Data System (ADS)

Ogle, Patrick M.; Lanz, Lauranne; Nader, Cyril; Helou, George

2016-02-01

We report the discovery of spiral galaxies that are as optically luminous as elliptical brightest cluster galaxies, with r-band monochromatic luminosity Lr = 8-14L* (4.3-7.5 × 1044 erg s-1). These super spiral galaxies are also giant and massive, with diameter D = 57-134 kpc and stellar mass Mstars = 0.3-3.4 × 1011M⊙. We find 53 super spirals out of a complete sample of 1616 SDSS galaxies with redshift z < 0.3 and Lr > 8L*. The closest example is found at z = 0.089. We use existing photometry to estimate their stellar masses and star formation rates (SFRs). The SDSS and Wide-field Infrared Survey Explorer colors are consistent with normal star-forming spirals on the blue sequence. However, the extreme masses and rapid SFRs of 5-65 M⊙ yr-1 place super spirals in a sparsely populated region of parameter space, above the star-forming main sequence of disk galaxies. Super spirals occupy a diverse range of environments, from isolation to cluster centers. We find four super spiral galaxy systems that are late-stage major mergers—a possible clue to their formation. We suggest that super spirals are a remnant population of unquenched, massive disk galaxies. They may eventually become massive lenticular galaxies after they are cut off from their gas supply and their disks fade.

Benchmark studies of thermal jet mixing in SFRs using a two-jet model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Omotowa, O. A.; Skifton, R.; Tokuhiro, A.

To guide the modeling, simulations and design of Sodium Fast Reactors (SFRs), we explore and compare the predictive capabilities of two numerical solvers COMSOL and OpenFOAM in the thermal jet mixing of two buoyant jets typical of the outlet flow from a SFR tube bundle. This process will help optimize on-going experimental efforts at obtaining high resolution data for V and V of CFD codes as anticipated in next generation nuclear systems. Using the k-{epsilon} turbulence models of both codes as reference, their ability to simulate the turbulence behavior in similar environments was first validated for single jet experimental datamore » reported in literature. This study investigates the thermal mixing of two parallel jets having a temperature difference (hot-to-cold) {Delta}T{sub hc}= 5 deg. C, 10 deg. C and velocity ratios U{sub c}/U{sub h} = 0.5, 1. Results of the computed turbulent quantities due to convective mixing and the variations in flow field along the axial position are presented. In addition, this study also evaluates the effect of spacing ratio between jets in predicting the flow field and jet behavior in near and far fields. (authors)« less

The galaxy-wide initial mass function of dwarf late-type to massive early-type galaxies

NASA Astrophysics Data System (ADS)

Weidner, C.; Kroupa, P.; Pflamm-Altenburg, J.; Vazdekis, A.

2013-12-01

Observational studies are showing that the galaxy-wide stellar initial mass function (IMF) is top-heavy in galaxies with high star formation rates (SFRs). Calculating the integrated galactic stellar initial mass function (IGIMF) as a function of the SFR of a galaxy, it follows that galaxies which have or which formed with SFRs >10 M⊙ yr-1 would have a top-heavy IGIMF in excellent consistency with the observations. Consequently and in agreement with observations, elliptical galaxies would have higher mass-to-light ratios as a result of the overabundance of stellar remnants compared to a stellar population that formed with an invariant canonical stellar IMF. For the Milky Way, the IGIMF yields very good agreement with the disc- and the bulge IMF determinations. Our conclusions are that purely stochastic descriptions of star formation on the scales of a parsec and above are falsified. Instead, star formation follows the laws, stated here as axioms, which define the IGIMF theory. We also find evidence that the power-law index β of the embedded cluster mass function decreases with increasing SFR. We propose further tests of the IGIMF theory through counting massive stars in dwarf galaxies.

SIGNIFICANT ENHANCEMENT OF H{sub 2} FORMATION IN DISK GALAXIES UNDER STRONG RAM PRESSURE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henderson, Benjamin; Bekki, Kenji

We show for the first time that H{sub 2} formation on dust grains can be enhanced in disk galaxies under strong ram pressure (RP). We numerically investigate how the time evolution of H i and H{sub 2} components in disk galaxies orbiting a group/cluster of galaxies can be influenced by the hydrodynamical interaction between the gaseous components of the galaxies and the hot intracluster medium. We find that compression of H i caused by RP increases H{sub 2} formation in disk galaxies before RP rapidly strips H i, cutting off the fuel supply and causing a drop in H{sub 2}more » density. We also find that the level of this H{sub 2} formation enhancement in a disk galaxy under RP depends on the mass of its host cluster dark matter halo, the initial positions and velocities of the disk galaxy, and the disk inclination angle with respect to the orbital plane. We demonstrate that dust growth is a key factor in the evolution of the H i and H{sub 2} mass in disk galaxies under strong RP. We discuss how the correlation between H{sub 2} fractions and surface gas densities of disk galaxies evolves with time in the galaxies under RP. We also discuss whether galaxy-wide star formation rates (SFRs) in cluster disk galaxies can be enhanced by RP if the SFRs depend on H{sub 2} densities.« less

Kinematics, turbulence, and star formation of z ˜ 1 strongly lensed galaxies seen with MUSE

NASA Astrophysics Data System (ADS)

Patrício, V.; Richard, J.; Carton, D.; Contini, T.; Epinat, B.; Brinchmann, J.; Schmidt, K. B.; Krajnović, D.; Bouché, N.; Weilbacher, P. M.; Pelló, R.; Caruana, J.; Maseda, M.; Finley, H.; Bauer, F. E.; Martinez, J.; Mahler, G.; Lagattuta, D.; Clément, B.; Soucail, G.; Wisotzki, L.

2018-06-01

We analyse a sample of eight highly magnified galaxies at redshift 0.6 < z < 1.5 observed with MUSE, exploring the resolved properties of these galaxies at sub-kiloparsec scales. Combining multiband HST photometry and MUSE spectra, we derive the stellar mass, global star formation rates (SFRs), extinction and metallicity from multiple nebular lines, concluding that our sample is representative of z ˜ 1 star-forming galaxies. We derive the 2D kinematics of these galaxies from the [O II ] emission and model it with a new method that accounts for lensing effects and fits multiple images simultaneously. We use these models to calculate the 2D beam-smearing correction and derive intrinsic velocity dispersion maps. We find them to be fairly homogeneous, with relatively constant velocity dispersions between 15 and 80 km s-1 and Gini coefficient of {≲ }0.3. We do not find any evidence for higher (or lower) velocity dispersions at the positions of bright star-forming clumps. We derive resolved maps of dust attenuation and attenuation-corrected SFRs from emission lines for two objects in the sample. We use this information to study the relation between resolved SFR and velocity dispersion. We find that these quantities are not correlated, and the high-velocity dispersions found for relatively low star-forming densities seems to indicate that, at sub-kiloparsec scales, turbulence in high-z discs is mainly dominated by gravitational instability rather than stellar feedback.

Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

PubMed Central

Marcel, V; Fernandes, K; Terrier, O; Lane, D P; Bourdon, J-C

2014-01-01

In addition to the tumor suppressor p53 protein, also termed p53α, the TP53 gene produces p53β and p53γ through alternative splicing of exons 9β and 9γ located within TP53 intron 9. Here we report that both TG003, a specific inhibitor of Cdc2-like kinases (Clk) that regulates the alternative splicing pre-mRNA pathway, and knockdown of SFRS1 increase expression of endogenous p53β and p53γ at mRNA and protein levels. Development of a TP53 intron 9 minigene shows that TG003 treatment and knockdown of SFRS1 promote inclusion of TP53 exons 9β/9γ. In a series of 85 primary breast tumors, a significant association was observed between expression of SFRS1 and α variant, supporting our experimental data. Using siRNA specifically targeting exons 9β/9γ, we demonstrate that cell growth can be driven by modulating p53β and p53γ expression in an opposite manner, depending on the cellular context. In MCF7 cells, p53β and p53γ promote apoptosis, thus inhibiting cell growth. By transient transfection, we show that p53β enhanced p53α transcriptional activity on the p21 and Bax promoters, while p53γ increased p53α transcriptional activity on the Bax promoter only. Moreover, p53β and p53γ co-immunoprecipitate with p53α only in the presence of p53-responsive promoter. Interestingly, although p53β and p53γ promote apoptosis in MCF7 cells, p53β and p53γ maintain cell growth in response to TG003 in a p53α-dependent manner. The dual activities of p53β and p53γ isoforms observed in non-treated and TG003-treated cells may result from the impact of TG003 on both expression and activities of p53 isoforms. Overall, our data suggest that p53β and p53γ regulate cellular response to modulation of alternative splicing pre-mRNA pathway by a small drug inhibitor. The development of novel drugs targeting alternative splicing process could be used as a novel therapeutic approach in human cancers. PMID:24926616

Star-forming galaxies are predicted to lie on a fundamental plane of mass, star formation rate and α-enhancement

NASA Astrophysics Data System (ADS)

Matthee, Jorryt; Schaye, Joop

2018-05-01

Observations show that star-forming galaxies reside on a tight three-dimensional plane between mass, gas-phase metallicity and star formation rate (SFR), which can be explained by the interplay between metal-poor gas inflows, SFR and outflows. However, different metals are released on different time-scales, which may affect the slope of this relation. Here, we use central, star-forming galaxies with Mstar = 109.0 - 10.5 M⊙ from the EAGLE hydrodynamical simulation to examine three-dimensional relations between mass, SFR and chemical enrichment using absolute and relative C, N, O and Fe abundances. We show that the scatter is smaller when gas-phase α-enhancement is used rather than metallicity. A similar plane also exists for stellar α-enhancement, implying that present-day specific SFRs are correlated with long time-scale star formation histories. Between z = 0 and 1, the α-enhancement plane is even more insensitive to redshift than the plane using metallicity. However, it evolves at z > 1 due to lagging iron yields. At fixed mass, galaxies with higher SFRs have star formation histories shifted toward late times, are more α-enhanced and this α-enhancement increases with redshift as observed. These findings suggest that relations between physical properties inferred from observations may be affected by systematic variations in α-enhancements.

EVIDENCE FOR ELEVATED X-RAY EMISSION IN LOCAL LYMAN BREAK GALAXY ANALOGS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basu-Zych, Antara R.; Lehmer, Bret D.; Hornschemeier, Ann E.

2013-09-10

Our knowledge of how X-ray emission scales with star formation at the earliest times in the universe relies on studies of very distant Lyman break galaxies (LBGs). In this paper, we study the relationship between the 2-10 keV X-ray luminosity (L{sub X}), assumed to originate from X-ray binaries (XRBs), and star formation rate (SFR) in ultraviolet (UV) selected z < 0.1 Lyman break analogs (LBAs). We present Chandra observations for four new Galaxy Evolution Explorer selected LBAs. Including previously studied LBAs, Haro 11 and VV 114, we find that LBAs demonstrate L{sub X}/SFR ratios that are elevated by {approx}1.5{sigma} comparedmore » to local galaxies, similar to the ratios found for stacked LBGs in the early universe (z > 2). Unlike some of the composite LBAs studied previously, we show that these LBAs are unlikely to harbor active galactic nuclei, based on their optical and X-ray spectra and the spatial distribution of the X-rays in three spatially extended cases. Instead, we expect that high-mass X-ray binaries (HMXBs) dominate the X-ray emission in these galaxies, based on their high specific SFRs (sSFRs {identical_to} SFR/M{sub *} {>=} 10{sup -9} yr{sup -1}), which suggest the prevalence of young stellar populations. Since both UV-selected populations (LBGs and LBAs) have lower dust attenuations and metallicities compared to similar samples of more typical local galaxies, we investigate the effects of dust extinction and metallicity on the L{sub X}/SFR for the broader population of galaxies with high sSFRs (>10{sup -10} yr{sup -1}). The estimated dust extinctions (corresponding to column densities of N{sub H} < 10{sup 22} cm{sup -2}) are expected to have insignificant effects on observed L{sub X}/SFR ratio for the majority of galaxy samples. We find that the observed relationship between L{sub X}/SFR and metallicity appears consistent with theoretical expectations from XRB population synthesis models. Therefore, we conclude that lower metallicities, related to more luminous HMXBs such as ultraluminous X-ray sources, drive the elevated L{sub X}/SFR observed in our sample of z < 0.1 LBAs. The relatively metal-poor, active mode of star formation in LBAs and distant z > 2 LBGs may yield higher total HMXB luminosity than found in typical galaxies in the local universe.« less

VizieR Online Data Catalog: 6 & 1.3cm deep VLA obs. toward 58 high-mass SFRs (Rosero+, 2016)

NASA Astrophysics Data System (ADS)

Rosero, V.; Hofner, P.; Claussen, M.; Kurtz, S.; Cesaroni, R.; Araya, E. D.; Carrasco-Gonzalez, C.; Rodriguez, L. F.; Menten, K. M.; Wyrowski, F.; Loinard, L.; Ellingsen, S. P.

2017-01-01

VLA continuum observations (project codes 10B-124 and 13B-210) at 6 and 1.3cm were made for all sources in the sample. The 6cm observations were made in the A configuration between 2011 June and August, providing a typical angular resolution of about 0.4". The 1.3cm observations were made in the B configuration, acquiring the first half of the data between 2010 November and 2011 May, and the second half between 2013 November and 2014 January. (2 data files).

Is stellar multiplicity universal? Tight stellar binaries in the Orion Nebula Cluster

NASA Astrophysics Data System (ADS)

Duchêne, Gaspard; Lacour, S.; Moraux, E.; Goodwin, S.; Bouvier, J.

2018-05-01

We present a survey for the tightest visual binaries among 0.3-2 M⊙ members the Orion Nebula Cluster (ONC). Among 42 targets, we discovered 13 new 0{^''.}025-0{^''.}15 companions. Accounting for the Branch bias, we find a companion star fraction (CSF) in the 10-60 au range of 21^{+8}_{-5}%, consistent with that observed in other star-forming regions (SFRs) and twice as high as among field stars; this excess is found with a high level of confidence. Since our sample is dominated by disk-bearing targets, this indicates that disk disruption by close binaries is inefficient, or has not yet taken place, in the ONC. The resulting separation distribution in the ONC drops sharply outside 60 au. These findings are consistent with a scenario in which the initial multiplicity properties, set by the star formation process itself, are identical in the ONC and in other SFRs and subsequently altered by the cluster's dynamical evolution. This implies that the fragmentation process does not depend on the global properties of a molecular cloud, but on the local properties of prestellar cores, and that the latter are self-regulated to be nearly identical in a wide range of environments. These results, however, raise anew the question of the origin of field stars as the tight binaries we have discovered will not be destroyed as the ONC dissolves into the galactic field. It thus appears that most field stars formed in regions that differ from well-studied SFRs in the Solar neighborhood, possibly due to changes in core fragmentation on Gyr timescales.

Mapping Extinction and Star Formation Rates of Nearby Galaxies

NASA Astrophysics Data System (ADS)

Ridenour, Anthony; Takamiya, M.

2010-01-01

Star Formation Rate (SFR) is a physical characteristic of galaxies vital to our understanding of such problems as the evolution of the Universe. In computing SFRs obscuring dust systematically lowers them at shorter wavelengths compared to longer wavelengths. This issue of dust extinction has been handled well by multi-wavelength studies of nearby galaxies. Star Formation Rate measurements of distant galaxies are currently reliant on the emission of visible spectroscopic lines like Hα and [OII] after correction for extinction. However, if the visible light is completely obscured an incorrect assumption may be drawn; namely that there is neither SFR nor extinction. The work purposed here is to calibrate the SFR ascertained from Hα emission in nearby galaxies and compare it to radio and infrared emission. The Balmer decrement, or the ratio of Hβ to Hα emission, used to determine extinction, will also be studied and compared to infrared images. 30 nearby galaxies will be sampled and 2-D maps and Balmer decrements will be formed to do two things: measure SFRs and determine differences between Hα and infrared emission, and explore in what ways this difference corresponds with such things as the radio SFR, galaxy luminosity and morphological type. The accuracy of Hα as a SFR indicator and its determination as a sound tool in measuring SFRs of distant galaxies can both be quantified by interpreting these maps. Dr. Marianne Takamiya, the principal investigator and my mentor, secured funds through a grant to the University of Hawai'i at Hilo from The Research Corporation for Science Advancement Cottrell College Science Awards for this research.

FY15 Status Report on NEAMS Neutronics Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, C. H.; Shemon, E. R.; Smith, M. A.

2015-09-30

This report summarizes the current status of NEAMS activities in FY2015. The tasks this year are (1) to improve solution methods for steady-state and transient conditions, (2) to develop features and user friendliness to increase the usability and applicability of the code, (3) to improve and verify the multigroup cross section generation scheme, (4) to perform verification and validation tests of the code using SFRs and thermal reactor cores, and (5) to support early users of PROTEUS and update the user manuals.

VizieR Online Data Catalog: Type 2 AGN host galaxies in Chandra-COSMOS (Suh+, 2017)

NASA Astrophysics Data System (ADS)

Suh, H.; Civano, F.; Hasinger, G.; Lusso, E.; Lanzuisi, G.; Marchesi, S.; Trakhtenbrot, B.; Allevato, V.; Cappelluti, N.; Capak, P. L.; Elvis, M.; Griffiths, R. E.; Laigle, C.; Lira, P.; Riguccini, L.; Rosario, D. J.; Salvato, M.; Schawinski, K.; Vignali, C.

2018-01-01

We investigate the star formation properties of a large sample of ~2300 X-ray-selected Type 2 Active Galactic Nuclei (AGNs) host galaxies out to z~3 in the Chandra COSMOS Legacy Survey in order to understand the connection between the star formation and nuclear activity. Making use of the existing multi-wavelength photometric data available in the COSMOS field, we perform a multi-component modeling from far-infrared to near-ultraviolet using a nuclear dust torus model, a stellar population model and a starburst model of the spectral energy distributions (SEDs). Through detailed analyses of SEDs, we derive the stellar masses and the star formation rates (SFRs) of Type 2 AGN host galaxies. The stellar mass of our sample is in the range of 93), and grow slowly through secular fueling processes hosting moderate-luminosity AGNs. (1 data file).

Prevalence of Hyposalivation in Patients with Systemic Lupus Erythematosus in a Brazilian Subpopulation

PubMed Central

Leite, Cristhiane Almeida; Galera, Marcial Francis; Espinosa, Mariano Martínez; de Lima, Paulo Ricardo Teles; Fernandes, Vander; Borges, Álvaro Henrique; Dias, Eliane Pedra

2015-01-01

Background. Systemic lupus erythematosus (SLE) is a chronic inflammatory, multisystem, and autoimmune disease. Objective. The aim of this study was to describe the prevalence of hyposalivation in SLE patients and evaluate factors associated. Methods. This is a cross-sectional study developed at the Cuiaba University General Hospital (UNIC-HGU), Mato Grosso, Brazil. The study population consisted of female SLE patients treated at this hospital from 06/2010 to 12/2012. Unstimulated salivary flow rates (SFRs) were measured. Descriptive and inferential analyses were performed in all cases using a significance level P < 0.05. Results. The results showed that 79% of patients with systemic lupus erythematosus suffered from hyposalivation and that the disease activity and age in years were the factors that resulted in statistically significant differences. Conclusion. The activity of the disease, age >27 years, and the drugs used were factors associated with hyposalivation, resulting in a statistically significant decrease in saliva production. PMID:25649631

Deep 1.1 mm-wavelength imaging of the GOODS-S field by AzTEC/ASTE - II. Redshift distribution and nature of the submillimetre galaxy population

NASA Astrophysics Data System (ADS)

Yun, Min S.; Scott, K. S.; Guo, Yicheng; Aretxaga, I.; Giavalisco, M.; Austermann, J. E.; Capak, P.; Chen, Yuxi; Ezawa, H.; Hatsukade, B.; Hughes, D. H.; Iono, D.; Johnson, S.; Kawabe, R.; Kohno, K.; Lowenthal, J.; Miller, N.; Morrison, G.; Oshima, T.; Perera, T. A.; Salvato, M.; Silverman, J.; Tamura, Y.; Williams, C. C.; Wilson, G. W.

2012-02-01

We report the results of the counterpart identification and a detailed analysis of the physical properties of the 48 sources discovered in our deep 1.1-mm wavelength imaging survey of the Great Observatories Origins Deep Survey-South (GOODS-S) field using the AzTEC instrument on the Atacama Submillimeter Telescope Experiment. One or more robust or tentative counterpart candidate is found for 27 and 14 AzTEC sources, respectively, by employing deep radio continuum, Spitzer/Multiband Imaging Photometer for Spitzer and Infrared Array Camera, and Large APEX Bolometer Camera 870 μm data. Five of the sources (10 per cent) have two robust counterparts each, supporting the idea that these galaxies are strongly clustered and/or heavily confused. Photometric redshifts and star formation rates (SFRs) are derived by analysing ultraviolet(UV)-to-optical and infrared(IR)-to-radio spectral energy distributions (SEDs). The median redshift of zmed˜ 2.6 is similar to other earlier estimates, but we show that 80 per cent of the AzTEC-GOODS sources are at z≥ 2, with a significant high-redshift tail (20 per cent at z≥ 3.3). Rest-frame UV and optical properties of AzTEC sources are extremely diverse, spanning 10 mag in the i- and K-band photometry (a factor of 104 in flux density) with median values of i= 25.3 and K= 22.6 and a broad range of red colour (i-K= 0-6) with an average value of i-K≈ 3. These AzTEC sources are some of the most luminous galaxies in the rest-frame optical bands at z≥ 2, with inferred stellar masses M*= (1-30) × 1010 M⊙ and UV-derived SFRs of SFRUV≳ 101-3 M⊙ yr-1. The IR-derived SFR, 200-2000 M⊙ yr-1, is independent of z or M*. The resulting specific star formation rates, SSFR ≈ 1-100 Gyr-1, are 10-100 times higher than similar mass galaxies at z= 0, and they extend the previously observed rapid rise in the SSFR with redshift to z= 2-5. These galaxies have a SFR high enough to have built up their entire stellar mass within their Hubble time. We find only marginal evidence for an active galactic nucleus (AGN) contribution to the near-IR and mid-IR SEDs, even among the X-ray detected sources, and the derived M* and SFR show little dependence on the presence of an X-ray bright AGN.

Deep Submillimeter and Radio Observations in the SSA22 Field. I. Powering Sources and the Lyα Escape Fraction of Lyα Blobs

NASA Astrophysics Data System (ADS)

Ao, Y.; Matsuda, Y.; Henkel, C.; Iono, D.; Alexander, D. M.; Chapman, S. C.; Geach, J.; Hatsukade, B.; Hayes, M.; Hine, N. K.; Kato, Y.; Kawabe, R.; Kohno, K.; Kubo, M.; Lehnert, M.; Malkan, M.; Menten, K. M.; Nagao, T.; Norris, R. P.; Ouchi, M.; Saito, T.; Tamura, Y.; Taniguchi, Y.; Umehata, H.; Weiss, A.

2017-12-01

We study the heating mechanisms and Lyα escape fractions of 35 Lyα blobs (LABs) at z ≈ 3.1 in the SSA22 field. Dust continuum sources have been identified in 11 of the 35 LABs, all with star formation rates (SFRs) above 100 M ⊙ yr-1. Likely radio counterparts are detected in 9 out of 29 investigated LABs. The detection of submillimeter dust emission is more linked to the physical size of the Lyα emission than to the Lyα luminosities of the LABs. A radio excess in the submillimeter/radio-detected LABs is common, hinting at the presence of active galactic nuclei. Most radio sources without X-ray counterparts are located at the centers of the LABs. However, all X-ray counterparts avoid the central regions. This may be explained by absorption due to exceptionally large column densities along the line-of-sight or by LAB morphologies, which are highly orientation dependent. The median Lyα escape fraction is about 3% among the submillimeter-detected LABs, which is lower than a lower limit of 11% for the submillimeter-undetected LABs. We suspect that the large difference is due to the high dust attenuation supported by the large SFRs, the dense large-scale environment as well as large uncertainties in the extinction corrections required to apply when interpreting optical data.

Direct Measurements of Dust Attenuation in z ~ 1.5 Star-forming Galaxies from 3D-HST: Implications for Dust Geometry and Star Formation Rates

NASA Astrophysics Data System (ADS)

Price, Sedona H.; Kriek, Mariska; Brammer, Gabriel B.; Conroy, Charlie; Förster Schreiber, Natascha M.; Franx, Marijn; Fumagalli, Mattia; Lundgren, Britt; Momcheva, Ivelina; Nelson, Erica J.; Skelton, Rosalind E.; van Dokkum, Pieter G.; Whitaker, Katherine E.; Wuyts, Stijn

2014-06-01

The nature of dust in distant galaxies is not well understood, and until recently few direct dust measurements have been possible. We investigate dust in distant star-forming galaxies using near-infrared grism spectra of the 3D-HST survey combined with archival multi-wavelength photometry. These data allow us to make a direct comparison between dust around star-forming regions (A V, H II ) and the integrated dust content (A V, star). We select a sample of 163 galaxies between 1.36 <= z <= 1.5 with Hα signal-to-noise ratio >=5 and measure Balmer decrements from stacked spectra to calculate A V, H II . First, we stack spectra in bins of A V, star, and find that A V, H II = 1.86 A V, star, with a significance of σ = 1.7. Our result is consistent with the two-component dust model, in which galaxies contain both diffuse and stellar birth cloud dust. Next, we stack spectra in bins of specific star formation rate (log SSFR), star formation rate (log SFR), and stellar mass (log M *). We find that on average A V, H II increases with SFR and mass, but decreases with increasing SSFR. Interestingly, the data hint that the amount of extra attenuation decreases with increasing SSFR. This trend is expected from the two-component model, as the extra attenuation will increase once older stars outside the star-forming regions become more dominant in the galaxy spectrum. Finally, using Balmer decrements we derive dust-corrected Hα SFRs, and find that stellar population modeling produces incorrect SFRs if rapidly declining star formation histories are included in the explored parameter space.

VLA and ALMA Imaging of Intense Galaxy-wide Star Formation in z ˜ 2 Galaxies

NASA Astrophysics Data System (ADS)

Rujopakarn, W.; Dunlop, J. S.; Rieke, G. H.; Ivison, R. J.; Cibinel, A.; Nyland, K.; Jagannathan, P.; Silverman, J. D.; Alexander, D. M.; Biggs, A. D.; Bhatnagar, S.; Ballantyne, D. R.; Dickinson, M.; Elbaz, D.; Geach, J. E.; Hayward, C. C.; Kirkpatrick, A.; McLure, R. J.; Michałowski, M. J.; Miller, N. A.; Narayanan, D.; Owen, F. N.; Pannella, M.; Papovich, C.; Pope, A.; Rau, U.; Robertson, B. E.; Scott, D.; Swinbank, A. M.; van der Werf, P.; van Kampen, E.; Weiner, B. J.; Windhorst, R. A.

2016-12-01

We present ≃0.″4 resolution extinction-independent distributions of star formation and dust in 11 star-forming galaxies (SFGs) at z = 1.3-3.0. These galaxies are selected from sensitive blank-field surveys of the 2‧ × 2‧ Hubble Ultra-Deep Field at λ = 5 cm and 1.3 mm using the Karl G. Jansky Very Large Array and Atacama Large Millimeter/submillimeter Array. They have star formation rates (SFRs), stellar masses, and dust properties representative of massive main-sequence SFGs at z ˜ 2. Morphological classification performed on spatially resolved stellar mass maps indicates a mixture of disk and morphologically disturbed systems; half of the sample harbor X-ray active galactic nuclei (AGNs), thereby representing a diversity of z ˜ 2 SFGs undergoing vigorous mass assembly. We find that their intense star formation most frequently occurs at the location of stellar-mass concentration and extends over an area comparable to their stellar-mass distribution, with a median diameter of 4.2 ± 1.8 kpc. This provides direct evidence of galaxy-wide star formation in distant blank-field-selected main-sequence SFGs. The typical galactic-average SFR surface density is 2.5 M ⊙ yr-1 kpc-2, sufficiently high to drive outflows. In X-ray-selected AGN where radio emission is enhanced over the level associated with star formation, the radio excess pinpoints the AGNs, which are found to be cospatial with star formation. The median extinction-independent size of main-sequence SFGs is two times larger than those of bright submillimeter galaxies, whose SFRs are 3-8 times larger, providing a constraint on the characteristic SFR (˜300 M ⊙ yr-1) above which a significant population of more compact SFGs appears to emerge.

Understory and small trees contribute importantly to stemflow of a lower montane cloud forest

NASA Astrophysics Data System (ADS)

González Martínez, T. M.; Wiliams-Linera, G.; Holwerda, F.

2016-12-01

Stemflow (Sf) measurements in rainforests and montane forests dominated by large trees rarely include the understory and small trees. In the present study, contributions of woody understory (> 1 m height and < 5 cm DBH), small trees (5 < DBH < 10 cm) and upper canopy trees (> 10 cm DBH) to overall Sf of a lower montane cloud forest in central Veracruz, Mexico, were quantified. Incident precipitation (P), Sf volume and vegetation structure were measured. Subsequently, stemflow funneling ratios (SFR) were calculated, and allometric relationships between tree basal area and Sf volume were used to scale up measurements from individual trees to the stand level. Additionally, two other common methods to calculate areal Sf were used for comparative purposes. Understory woody plants, small trees and upper canopy trees represented 96, 2 and 2 %, respectively, of the total density. Upper canopy trees had the lowest SFRs (1.6 ± 0.5 on average), while the lower understory (> 1 m and < 2 m height) had the highest (36.1 ± 6.4). Small trees and upper understory (> 2 m) presented similar SFRs (22.9 ± 5.4 and 20.2 ± 3.9, respectively). Different scaling methods yielded very similar results for all but the upper understory. Overall areal Sf during the study period was 19 mm (3.8 % of rainfall), to which the understory contributed 66.3 % (12.6 mm), small trees 12.6 % (2.4 mm) and upper canopy trees 21.1 % (4.0 mm). Our results suggest that woody understory vegetation and small trees can have an important role in Sf generation of tall humid tropical forests, provided that the density of plants in these groups is high enough.

EVOLUTION OF GALAXIES AND THEIR ENVIRONMENTS AT z = 0.1-3 IN COSMOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scoville, N.; Benson, A.; Fu, Hai

2013-05-01

Large-scale structures (LSSs) out to z < 3.0 are measured in the Cosmic Evolution Survey (COSMOS) using extremely accurate photometric redshifts (photoz). The K{sub s} -band-selected sample (from Ultra-Vista) is comprised of 155,954 galaxies. Two techniques-adaptive smoothing and Voronoi tessellation-are used to estimate the environmental densities within 127 redshift slices. Approximately 250 statistically significant overdense structures are identified out to z = 3.0 with shapes varying from elongated filamentary structures to more circularly symmetric concentrations. We also compare the densities derived for COSMOS with those based on semi-analytic predictions for a {Lambda}CDM simulation and find excellent overall agreement between themore » mean densities as a function of redshift and the range of densities. The galaxy properties (stellar mass, spectral energy distributions (SEDs), and star formation rates (SFRs)) are strongly correlated with environmental density and redshift, particularly at z < 1.0-1.2. Classifying the spectral type of each galaxy using the rest-frame b - i color (from the photoz SED fitting), we find a strong correlation of early-type galaxies (E-Sa) with high-density environments, while the degree of environmental segregation varies systematically with redshift out to z {approx} 1.3. In the highest density regions, 80% of the galaxies are early types at z = 0.2 compared to only 20% at z = 1.5. The SFRs and the star formation timescales exhibit clear environmental correlations. At z > 0.8, the SFR density is uniformly distributed over all environmental density percentiles, while at lower redshifts the dominant contribution is shifted to galaxies in lower density environments.« less

The Relation between Luminous AGNs and Star Formation in Their Host Galaxies

NASA Astrophysics Data System (ADS)

Xu, Lei; Rieke, G. H.; Egami, E.; Haines, C. P.; Pereira, M. J.; Smith, G. P.

2015-08-01

We study the relation of active galactic nuclei (AGNs) to star formation in their host galaxies. Our sample includes 205 Type-1 and 85 Type-2 AGNs, 162 detected with Herschel, from fields surrounding 30 galaxy clusters in the Local Cluster Substructure Survey. The sample is identified by optical line widths and ratios after selection to be brighter than 1 mJy at 24 μm. We show that Type-2 AGN [O iii]λ5007 line fluxes at high z can be contaminated by their host galaxies with typical spectrograph entrance apertures (but our sample is not compromised in this way). We use spectral energy distribution (SED) templates to decompose the galaxy SEDs and estimate star formation rates (SFRs), AGN luminosities, and host galaxy stellar masses (described in an accompanying paper). The AGNs arise from massive black holes (˜ 3× {10}8{M}⊙ ) accreting at ˜10% of the Eddington rate and residing in galaxies with stellar mass \\gt 3× {10}10{M}⊙ ; those detected with Herschel have IR luminosity from star formation in the range of {L}{SF,{IR}}˜ {10}10-{10}12{L}⊙ . We find that (1) the specific SFRs in the host galaxies are generally consistent with those of normal star-forming (main sequence) galaxies; (2) there is a strong correlation between the luminosities from star formation and the AGN; and (3) the correlation may not result from a causal connection, but could arise because the black hole mass (and hence AGN Eddington luminosity) and star formation are both correlated with the galaxy mass.

High-redshift galaxy populations and their descendants

NASA Astrophysics Data System (ADS)

Guo, Qi; White, Simon D. M.

2009-06-01

We study predictions in the concordance Λ cold dark matter cosmology for the abundance and clustering of high-redshift galaxies and for the properties of their descendants. We focus on three high-redshift populations: Lyman break galaxies (LBGs) at z ~ 3, optically selected star-forming galaxies at z ~ 2 (BXs) and distant red galaxies (DRGs) at z ~ 2. We select galaxies from mock catalogues based on the Millennium Simulation using the observational colour and apparent magnitude criteria. With plausible dust assumptions, our galaxy formation model can simultaneously reproduce the abundances, redshift distributions and clustering of all three observed populations. The star formation rates (SFRs) of model LBGs and BXs are lower than those quoted for the real samples, reflecting differing initial mass functions and scatter in model dust properties. About 85 per cent of model galaxies selected as DRGs are star forming, with SFRs in the range 1 to ~100Msolaryr-1. Model LBGs, BXs and DRGs together account for less than half of all star formation over the range 1.5 < z < 3.2; many massive, star-forming galaxies are predicted to be too heavily obscured to appear in these populations. Model BXs have metallicities which agree roughly with observation, but model LBGs are only slightly more metal poor, in disagreement with recent observational results. The model galaxies are predominantly disc dominated. Stellar masses for LBGs and BXs are ~109.9Msolar, and for DRGs are ~1010.7Msolar. Only about 30 per cent of model galaxies with M* > 1011Msolar are classified as LBGs or BXs at the relevant redshifts, while 65 per cent are classified as DRGs. Almost all model LBGs and BXs are the central galaxies of their dark haloes, but fewer than half of the haloes of any given mass have an LBG or BX central galaxy. Half of all LBG descendants at z = 2 would be identified as BXs, but very few as DRGs. Clustering increases with decreasing redshift for descendants of all three populations, becoming stronger than that of L* galaxies by z = 0, when many have become satellite galaxies and their typical stellar mass has increased by a factor of 10 for LBGs and BXs and by a factor of 3 for DRGs. This growth is dominated by star formation until z ~ 1 and thereafter by mergers. Merging is predicted to be more important for LBG and DRG descendants than for BX descendants. Most LBGs and DRGs end up as red ellipticals, while BXs have a more varied fate. Over 70 per cent of local galaxies with M* > 1011Msolar are predicted to have at least one LBG/BX/DRG progenitor.

In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis.

PubMed

Lim, Daniel A; Suárez-Fariñas, Mayte; Naef, Felix; Hacker, Coleen R; Menn, Benedicte; Takebayashi, Hirohide; Magnasco, Marcelo; Patil, Nila; Alvarez-Buylla, Arturo

2006-01-01

Neural stem cells and neurogenesis persist in the adult mammalian brain subventricular zone (SVZ). Cells born in the rodent SVZ migrate to the olfactory bulb (Ob) where they differentiate into interneurons. To determine the gene expression and functional profile of SVZ neurogenesis, we performed three complementary sets of transcriptional analysis experiments using Affymetrix GeneChips: (1) comparison of adult mouse SVZ and Ob gene expression profiles with those of the striatum, cerebral cortex, and hippocampus; (2) profiling of SVZ stem cells and ependyma isolated by fluorescent-activated cell sorting (FACS); and (3) analysis of gene expression changes during in vivo SVZ regeneration after anti-mitotic treatment. Gene Ontology (GO) analysis of data from these three separate approaches showed that in adult SVZ neurogenesis, RNA splicing and chromatin remodeling are biological processes as statistically significant as cell proliferation, transcription, and neurogenesis. In non-neurogenic brain regions, RNA splicing and chromatin remodeling were not prominent processes. Fourteen mRNA splicing factors including Sf3b1, Sfrs2, Lsm4, and Khdrbs1/Sam68 were detected along with 9 chromatin remodeling genes including Mll, Bmi1, Smarcad1, Baf53a, and Hat1. We validated the transcriptional profile data with Northern blot analysis and in situ hybridization. The data greatly expand the catalogue of cell cycle components, transcription factors, and migration genes for adult SVZ neurogenesis and reveal RNA splicing and chromatin remodeling as prominent biological processes for these germinal cells.

EVIDENCE FOR REDUCED SPECIFIC STAR FORMATION RATES IN THE CENTERS OF MASSIVE GALAXIES AT z  = 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jung, Intae; Finkelstein, Steven L.; Song, Mimi

2017-01-01

We perform the first spatially resolved stellar population study of galaxies in the early universe ( z = 3.5–6.5), utilizing the Hubble Space Telescope Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey imaging data set over the GOODS-S field. We select a sample of 418 bright and extended galaxies at z  = 3.5–6.5 from a parent sample of ∼8000 photometric-redshift-selected galaxies from Finkelstein et al. We first examine galaxies at 3.5 ≲ z ≲ 4.0 using additional deep K -band survey data from the HAWK-I UDS and GOODS Survey which covers the 4000 Å break at these redshifts. We measure the stellar mass,more » star formation rate, and dust extinction for galaxy inner and outer regions via spatially resolved spectral energy distribution fitting based on a Markov Chain Monte Carlo algorithm. By comparing specific star formation rates (sSFRs) between inner and outer parts of the galaxies we find that the majority of galaxies with high central mass densities show evidence for a preferentially lower sSFR in their centers than in their outer regions, indicative of reduced sSFRs in their central regions. We also study galaxies at z ∼ 5 and 6 (here limited to high spatial resolution in the rest-frame ultraviolet only), finding that they show sSFRs which are generally independent of radial distance from the center of the galaxies. This indicates that stars are formed uniformly at all radii in massive galaxies at z  ∼ 5–6, contrary to massive galaxies at z ≲ 4.« less

Decoupled black hole accretion and quenching: the relationship between BHAR, SFR and quenching in Milky Way- and Andromeda-mass progenitors since z = 2.5

NASA Astrophysics Data System (ADS)

Cowley, M. J.; Spitler, L. R.; Quadri, R. F.; Goulding, A. D.; Papovich, C.; Tran, K. V. H.; Labbé, I.; Alcorn, L.; Allen, R. J.; Forrest, B.; Glazebrook, K.; Kacprzak, G. G.; Morrison, G.; Nanayakkara, T.; Straatman, C. M. S.; Tomczak, A. R.

2018-01-01

We investigate the relationship between the black hole accretion rate (BHAR) and star formation rate (SFR) for Milky Way (MW) and Andromeda (M31)-mass progenitors from z = 0.2 to 2.5. We source galaxies from the Ks-band-selected ZFOURGE survey, which includes multiwavelength data spanning 0.3-160 μm. We use decomposition software to split the observed spectral energy distributions (SEDs) of our galaxies into their active galactic nuclei (AGNs) and star-forming components, which allows us to estimate BHARs and SFRs from the infrared (IR). We perform tests to check the robustness of these estimates, including a comparison with BHARs and SFRs derived from X-ray stacking and far-IR analysis, respectively. We find that, as the progenitors evolve their relative black hole-galaxy growth (i.e. their BHAR/SFR ratio) increases from low to high redshift. The MW-mass progenitors exhibit a log-log slope of 0.64 ± 0.11, while the M31-mass progenitors are 0.39 ± 0.08. This result contrasts with previous studies that find an almost flat slope when adopting X-ray-/AGN-selected or mass-limited samples and is likely due to their use of a broad mixture of galaxies with different evolutionary histories. Our use of progenitor-matched samples highlights the potential importance of carefully selecting progenitors when searching for evolutionary relationships between BHAR/SFRs. Additionally, our finding that BHAR/SFR ratios do not track the rate at which progenitors quench casts doubts over the idea that the suppression of star formation is predominantly driven by luminous AGN feedback (i.e. high BHARs).

Induced Star Formation

NASA Astrophysics Data System (ADS)

Kennicutt, Robert C., Jr.

Overview: Induced Star Formation and Interactions Introduction Historical Background: First Hints Systematic Studies: Starbursts Interactions and Nuclear activity IRAS and Ultralumious starburst Galaxies The 1990's: HST, Supercomputers, and the Distant Universe Key Questions and Issues Organization of Lectures Star Formation Properties of Normal Galaxies Observational Techniques Results: Star Formation in Normal Galaxies Interpretation: Star Formation Histories Global Star Formation in interacting Galaxies A Gallery of Interactions and Mergers Star Formation Statistics: Guilt By Association Tests SFRs in Interacting vs Noninteracting Galaxies Kinematic Properties and Regulation of SFRs Induced Nuclear Activity and Star Formation Background: Nuclear Spectra and Classification Nuclear Star Formation and Starbursts Nuclear Star Formation and Interactions Induced AGN Activity: Statistics of Seyfert Galaxies Environments of Quasars Kinematic Clues to the Triggering of AGNs Infrared Luminous Galaxies and Starbursts Background: IR Luminous Galaxies and IRAS Infrared Luminosity Function and Spectra Infrared Structure and Morphology Interstellar Gas X-Ray Emission and Superwinds Optical, UV, and Near-Infrared Spectra Radio Continuum Emission Evidence for Interactions and Mergers The Power Source: Starbursts or Dusty AGNs? Spectral Diagnostics of Starbursts Evolutionary Synthesis Models Applications: Integrated Colors of Interacting Galaxies Applications: Hα Emission, Colors, and SFRs Applications: Spectral Modelling of Evolved Starbursts Infrared Starbursts and the IMF in starbursts Triggering and Regulation of Star Formation: The Problem Introduction: Star Formation as a Nonlinear Process The schmidt Law in Normal Galaxies Star Formation Regimes in Interacting Galaxies Summary Triggering and Regulation of Starbusts: Theoretical Ideas Gravitational Star Formation Thresholds Cloud Collision Models Radial Transport of Gas: Clues from Barred Galaxies Simulations of Starbursts in Merging Galaxies The Cosmological Role of Interactions and Starbursts Interactions in Hierarchical Cosmology Interaction-Induced Star Formation Today Interaction-Induced Star Formation in the Past Disk kinematics and the Merger Rate Global Effects of Starbursts and Superwinds Concluding Remarks References

Evidence for Reduced Species Star Formation Rates in the Centers of Massive Galaxies at zeta = 4

NASA Technical Reports Server (NTRS)

Jung, Intae; Finkelstein, Steven L.; Song, Mimi; Dickinson, Mark; Dekel, Avishai; Ferguson, Henry C.; Fontana, Adriano; Koekemoer, Anton M.; Lu, Yu; Mobasher, Bahram;

Identification of Lectins from Metastatic Cancer Cells through Magnetic Glyconanoparticles

PubMed Central

Kavunja, Herbert W.; Voss, Patricia G.

2016-01-01

Cancer cells can have characteristic carbohydrate binding properties. Previously, it was shown that a highly metastatic melanoma cell line B16F10 bound to galacto-side-functionalized nanoparticles much stronger than the corresponding less metastatic B16F1 cells. To better understand the carbohydrate binding properties of cancer cells, herein, we report the isolation and characterization of endogenous galactose binding proteins from B16F10 cells using magnetic glyconanoparticles. The galactose-coated magnetic glyconanoparticles could bind with lectins present in the cells and be isolated through magnet-mediated separation. Through Western blot and mass spectrometry, the arginine/serine rich splicing factor Sfrs1 was identified as a galactose-selective endogenous lectin, overexpressed in B16F10 cells, compared with B16F1 cells. In addition, galactin-3 was found in higher amounts in B16F10 cells. Finally, the glyconanoparticles exhibited a superior efficiency in lectin isolation, from both protein mixtures and live cells, than the corresponding more traditional microparticles functionalized with carbohydrates. Thus, the magnetic glyconanoparticles present a useful tool for discovery of endogenous lectins, as well as binding partners of lectins, without prior knowledge of protein identities. PMID:27110035

A Multi-Wavelength Survey of Intermediate-Mass Star-Forming Regions

NASA Astrophysics Data System (ADS)

Lundquist, Michael J.; Kobulnicky, Henry A.; Kerton, Charles R.

2015-01-01

Current research into Galactic star formation has focused on either massive star-forming regions or nearby low-mass regions. We present results from a survey of Galactic intermediate-mass star-forming regions (IM SFRs). These regions were selected from IRAS colors that specify cool dust and large PAH contribution, suggesting that they produce stars up to but not exceeding about 8 solar masses. Using WISE data we have classified 984 candidate IM SFRs as star-like objects, galaxies, filamentary structures, or blobs/shells based on their mid-infrared morphologies. Focusing on the blobs/shells, we combined follow-up observations of deep near-infrared (NIR) imaging with optical and NIR spectroscopy to study the stellar content, confirming the intermediate-mass nature of these regions. We also gathered CO data from OSO and APEX to study the molecular content and dynamics of these regions. We compare these results to those of high-mass star formation in order to better understand their role in the star-formation paradigm.

Astronomy in Denver: Spatial distributions of dust properties via far-IR broadband map with HerPlaNS

NASA Astrophysics Data System (ADS)

Asano, Kentaro; Ueta, Toshiya; Ladjal, Djazia; Exter, Katrina; Otsuka, Masaaki; HerPlaNS Consortium

2018-06-01

We present the results of our analyses on dust properties in all of Galactic planetary nebulae based on 5-band broadband images in the far-IR taken with the Herschel Space Observatory.By fitting surface brightness distributions of dust thermal emission at 70, 160, 250, 350 and 500 microns with a single-temperature modified black body function, we derive spatially resolved maps of the dust emissivity power-law index (beta) and dust temperature (Td), as well as the column density.We find that circumstellar dust grains in PNe occupy a specific region in the beta-Td space, which is distinct from that occupied by dust grains in the Interstellar Matter (ISM) and star forming regions (SFRs). Unlike those in the ISM and SFRs, dust grains in PNe exhibit little variation in beta while a large spread in Td, suggesting rather homogeneous dust properties.This work is part of the Herschel Planetary Nebula Survey Plus (HerPlaNS+) supported by the NASA Astrophysics Data Analysis Program.

How Dead are Dead Galaxies? Mid-Infrared Fluxes of Quiescent Galaxies at Redshift 0.3< Z< 2.5: Implications for Star Formation Rates and Dust Heating

NASA Technical Reports Server (NTRS)

Fumagalli, Mattia; Labbe, Ivo; Patel, Shannon G.; Franx, Marijn; vanDokkum, Pieter; Brammer, Gabriel; DaCunha, Elisabete; FoersterSchreiber, Natascha M.; Kriek, Mariska; Quadri, Ryan;

Insights from Synthetic Star-forming Regions. III. Calibration of Measurement and Techniques of Star Formation Rates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koepferl, Christine M.; Robitaille, Thomas P.; Dale, James E., E-mail: koepferl@usm.lmu.de

Through an extensive set of realistic synthetic observations (produced in Paper I), we assess in this part of the paper series (Paper III) how the choice of observational techniques affects the measurement of star formation rates (SFRs) in star-forming regions. We test the accuracy of commonly used techniques and construct new methods to extract the SFR, so that these findings can be applied to measure the SFR in real regions throughout the Milky Way. We investigate diffuse infrared SFR tracers such as those using 24 μ m, 70 μ m and total infrared emission, which have been previously calibrated formore » global galaxy scales. We set up a toy model of a galaxy and show that the infrared emission is consistent with the intrinsic SFR using extra-galactic calibrated laws (although the consistency does not prove their reliability). For local scales, we show that these techniques produce completely unreliable results for single star-forming regions, which are governed by different characteristic timescales. We show how calibration of these techniques can be improved for single star-forming regions by adjusting the characteristic timescale and the scaling factor and give suggestions of new calibrations of the diffuse star formation tracers. We show that star-forming regions that are dominated by high-mass stellar feedback experience a rapid drop in infrared emission once high-mass stellar feedback is turned on, which implies different characteristic timescales. Moreover, we explore the measured SFRs calculated directly from the observed young stellar population. We find that the measured point sources follow the evolutionary pace of star formation more directly than diffuse star formation tracers.« less

Feedback first: the surprisingly weak effects of magnetic fields, viscosity, conduction and metal diffusion on sub-L* galaxy formation

NASA Astrophysics Data System (ADS)

Su, Kung-Yi; Hopkins, Philip F.; Hayward, Christopher C.; Faucher-Giguère, Claude-André; Kereš, Dušan; Ma, Xiangcheng; Robles, Victor H.

2017-10-01

Using high-resolution simulations with explicit treatment of stellar feedback physics based on the FIRE (Feedback In Realistic Environments) project, we study how galaxy formation and the interstellar medium (ISM) are affected by magnetic fields, anisotropic Spitzer-Braginskii conduction and viscosity, and sub-grid metal diffusion from unresolved turbulence. We consider controlled simulations of isolated (non-cosmological) galaxies but also a limited set of cosmological 'zoom-in' simulations. Although simulations have shown significant effects from these physics with weak or absent stellar feedback, the effects are much weaker than those of stellar feedback when the latter is modelled explicitly. The additional physics have no systematic effect on galactic star formation rates (SFRs). In contrast, removing stellar feedback leads to SFRs being overpredicted by factors of ˜10-100. Without feedback, neither galactic winds nor volume-filling hot-phase gas exist, and discs tend to runaway collapse to ultra-thin scaleheights with unphysically dense clumps congregating at the galactic centre. With stellar feedback, a multi-phase, turbulent medium with galactic fountains and winds is established. At currently achievable resolutions and for the investigated halo mass range 1010-1013 M⊙, the additional physics investigated here (magnetohydrodynamic, conduction, viscosity, metal diffusion) have only weak (˜10 per cent-level) effects on regulating SFR and altering the balance of phases, outflows or the energy in ISM turbulence, consistent with simple equipartition arguments. We conclude that galactic star formation and the ISM are primarily governed by a combination of turbulence, gravitational instabilities and feedback. We add the caveat that active galactic nucleus feedback is not included in the present work.

The Quest for Dusty Primeval Galaxies

NASA Astrophysics Data System (ADS)

Mancuso, C.; Lapi, A.; Danese, L.

2016-06-01

We exploit the continuity equation approach and the 'main sequence' star-formation timescales to show that the observed high abundance of galaxies with stellar masses ? a few >10^10 M_⊙ at redshift z >? 4 implies the existence of a galaxy population featuring large star formation rates (SFRs) ψ >? 10^2 M_⊙ yr^-1 in heavily dust-obscured conditions. These galaxies constitute the high-redshift counterparts of the dusty star-forming population already surveyed for z<3 in the far-IR band by the Herschel space observatory. We work out specific predictions for the evolution of the corresponding stellar mass and SFR functions out to z ˜ 10, elucidating that the number density at z 30 M_⊙ yr^-1 cannot be estimated relying on the UV luminosity function alone, even when standard corrections for dust extinction based on the UV slope are applied. We compute the number counts and redshift distributions (including galaxy-scale gravitational lensing) of this galaxy population, and show that current data from AzTEC-LABOCA, SCUBA-2 and ALMA-SPT surveys are already digging into it. We substantiate how an observational strategy based on a color preselection in the far-IR or (sub-)mm band with Herschel and SCUBA-2, supplemented by photometric data via on-source observations with ALMA, can allow to reconstruct the bright end of the SFR functions out to z ? 8. In parallel, such a challenging task can be managed by exploiting current UV surveys in combination with (sub-)mm observations by ALMA and NIKA2 and/or radio observations by SKA and its precursors.

EVIDENCE FOR NON-STELLAR REST-FRAME NEAR-IR EMISSION ASSOCIATED WITH INCREASED STAR FORMATION IN GALAXIES AT z ∼ 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lange, Johannes U.; Van Dokkum, Pieter G.; Momcheva, Ivelina G.

2016-03-01

We explore the presence of non-stellar rest-frame near-IR (2–5 μm) emission in galaxies at z ∼ 1. Previous studies identified this excess in relatively small samples and suggested that such non-stellar emission, which could be linked to the 3.3 μm polycyclic aromatic hydrocarbons feature or hot dust emission, is associated with an increased star formation rate (SFR). In this Letter, we confirm and quantify the presence of an IR excess in a significant fraction of galaxies in the 3D-HST GOODS catalogs. By constructing a matched sample of galaxies with and without strong non-stellar near-IR emission, we find that galaxies with such emissionmore » are predominantly star-forming galaxies. Moreover, star-forming galaxies with an excess show increased mid- and far-IR and Hα emission compared to other star-forming galaxies without. While galaxies with a near-IR excess show a larger fraction of individually detected X-ray active galactic nuclei (AGNs), an X-ray stacking analysis, together with the IR-colors and Hα profiles, shows that AGNs are unlikely to be the dominant source of excess in the majority of galaxies. Our results suggest that non-stellar near-IR emission is linked to increased SFRs and is ubiquitous among star-forming galaxies. As such, the near-IR emission might be a powerful tool to measure SFRs in the era of the James Webb Space Telescope.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ogle, Patrick M.; Lanz, Lauranne; Nader, Cyril

We report the discovery of spiral galaxies that are as optically luminous as elliptical brightest cluster galaxies, with r-band monochromatic luminosity L{sub r} = 8–14L* (4.3–7.5 × 10{sup 44} erg s{sup −1}). These super spiral galaxies are also giant and massive, with diameter D = 57–134 kpc and stellar mass M{sub stars} = 0.3–3.4 × 10{sup 11}M{sub ⊙}. We find 53 super spirals out of a complete sample of 1616 SDSS galaxies with redshift z < 0.3 and L{sub r} > 8L*. The closest example is found at z = 0.089. We use existing photometry to estimate their stellar masses and star formation rates (SFRs). The SDSS and Wide-field Infrared Survey Explorer colors aremore » consistent with normal star-forming spirals on the blue sequence. However, the extreme masses and rapid SFRs of 5–65 M{sub ⊙} yr{sup −1} place super spirals in a sparsely populated region of parameter space, above the star-forming main sequence of disk galaxies. Super spirals occupy a diverse range of environments, from isolation to cluster centers. We find four super spiral galaxy systems that are late-stage major mergers—a possible clue to their formation. We suggest that super spirals are a remnant population of unquenched, massive disk galaxies. They may eventually become massive lenticular galaxies after they are cut off from their gas supply and their disks fade.« less

Calibrating Star Formation in WISE Using Total Infrared Luminosity

NASA Astrophysics Data System (ADS)

Cluver, M. E.; Jarrett, T. H.; Dale, D. A.; Smith, J.-D. T.; August, Tamlyn; Brown, M. J. I.

2017-11-01

We present accurate resolved WISE photometry of galaxies in the combined SINGS and KINGFISH sample. The luminosities in the W3 12 μm and W4 23 μm bands are calibrated to star formation rates (SFRs) derived using the total infrared luminosity, avoiding UV/optical uncertainties due to dust extinction corrections. The W3 relation has a 1σ scatter of 0.15 dex that is over nearly 5 orders of magnitude in SFR and 12 μm luminosity, and a range in host stellar mass from dwarfs (107 {M}⊙ ) to ˜ 3× {M}{\\star } (1011.5 {M}⊙ ) galaxies. In the absence of deep silicate absorption features and powerful active galactic nuclei, we expect this to be a reliable SFR indicator chiefly due to the broad nature of the W3 band. By contrast, the W4 SFR relation shows more scatter (1σ =0.18 dex). Both relations show reasonable agreement with radio-continuum-derived SFRs and excellent accordance with so-called “hybrid” Hα + 24 μm and FUV+24 μm indicators. Moreover, the WISE SFR relations appear to be insensitive to the metallicity range in the sample. We also compare our results with IRAS-selected luminous infrared galaxies, showing that the WISE relations maintain concordance, but systematically deviate for the most extreme galaxies. Given the all-sky coverage of WISE and the performance of the W3 band as an SFR indicator, the {L}12μ {{m}} SFR relation could be of great use to studies of nearby galaxies and forthcoming large-area surveys at optical and radio wavelengths.

The mass-metallicity and fundamental metallicity relations at z > 2 using very large telescope and Subaru near-infrared spectroscopy of zCOSMOS galaxies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maier, C.; Ziegler, B. L.; Lilly, S. J.

2014-09-01

In the local universe, there is good evidence that, at a given stellar mass M, the gas-phase metallicity Z is anti-correlated with the star formation rate (SFR) of the galaxies. It has also been claimed that the resulting Z(M, SFR) relation is invariant with redshift—the so-called 'fundamental metallicity relation' (FMR). Given a number of difficulties in determining metallicities, especially at higher redshifts, the form of the Z(M, SFR) relation and whether it is really independent of redshift is still very controversial. To explore this issue at z > 2, we used VLT-SINFONI and Subaru-MOIRCS near-infrared spectroscopy of 20 zCOSMOS-deep galaxiesmore » at 2.1 < z < 2.5 to measure the strengths of up to five emission lines: [O II] λ3727, Hβ, [O III] λ5007, Hα, and [N II] λ6584. This near-infrared spectroscopy enables us to derive O/H metallicities, and also SFRs from extinction corrected Hα measurements. We find that the mass-metallicity relation (MZR) of these star-forming galaxies at z ≈ 2.3 is lower than the local Sloan Digital Sky Survey (SDSS) MZR by a factor of three to five, a larger change than found by Erb et al. using [N II]/Hα-based metallicities from stacked spectra. We discuss how the different selections of the samples and metallicity calibrations used may be responsible for this discrepancy. The galaxies show direct evidence that the SFR is still a second parameter in the MZR at these redshifts. However, determining whether the Z(M, SFR) relation is invariant with epoch depends on the choice of extrapolation used from local samples, because z > 2 galaxies of a given mass have much higher SFRs than the local SDSS galaxies. We find that the zCOSMOS galaxies are consistent with a non-evolving FMR if we use the physically motivated formulation of the Z(M, SFR) relation from Lilly et al., but not if we use the empirical formulation of Mannucci et al.« less

Gravitational lensing reveals extreme dust-obscured star formation in quasar host galaxies

NASA Astrophysics Data System (ADS)

Stacey, H. R.; McKean, J. P.; Robertson, N. C.; Ivison, R. J.; Isaak, K. G.; Schleicher, D. R. G.; van der Werf, P. P.; Baan, W. A.; Berciano Alba, A.; Garrett, M. A.; Loenen, A. F.

2018-06-01

We have observed 104 gravitationally lensed quasars at z ˜ 1-4 with Herschel/SPIRE, the largest such sample ever studied. By targeting gravitational lenses, we probe intrinsic far-infrared (FIR) luminosities and star formation rates (SFRs) more typical of the population than the extremely luminous sources that are otherwise accessible. We detect 72 objects with Herschel/SPIRE and find 66 per cent (69 sources) of the sample have spectral energy distributions (SEDs) characteristic of dust emission. For 53 objects with sufficiently constrained SEDs, we find a median effective dust temperature of 38^{+12}_{-5} K. By applying the radio-infrared correlation, we find no evidence for an FIR excess that is consistent with star-formation-heated dust. We derive a median magnification-corrected FIR luminosity of 3.6^{+4.8}_{-2.4} × 10^{11} L_{⊙} and median SFR of 120^{+160}_{-80} M_{⊙} yr^{-1}} for 94 quasars with redshifts. We find ˜10 per cent of our sample have FIR properties similar to typical dusty star-forming galaxies at z ˜ 2-3 and a range of SFRs <20-10 000 M⊙ yr-1 for our sample as a whole. These results are in line with current models of quasar evolution and suggests a coexistence of dust-obscured star formation and AGN activity is typical of most quasars. We do not find a statistically significant difference in the FIR luminosities of quasars in our sample with a radio excess relative to the radio-infrared correlation. Synchrotron emission is found to dominate at FIR wavelengths for <15 per cent of those sources classified as powerful radio galaxies.

Molecular Cloud Evolution VI. Measuring cloud ages

NASA Astrophysics Data System (ADS)

Vázquez-Semadeni, Enrique; Zamora-Avilés, Manuel; Galván-Madrid, Roberto; Forbrich, Jan

2018-06-01

In previous contributions, we have presented an analytical model describing the evolution of molecular clouds (MCs) undergoing hierarchical gravitational contraction. The cloud's evolution is characterized by an initial increase in its mass, density, and star formation rate (SFR) and efficiency (SFE) as it contracts, followed by a decrease of these quantities as newly formed massive stars begin to disrupt the cloud. The main parameter of the model is the maximum mass reached by the cloud during its evolution. Thus, specifying the instantaneous mass and some other variable completely determines the cloud's evolutionary stage. We apply the model to interpret the observed scatter in SFEs of the cloud sample compiled by Lada et al. as an evolutionary effect so that, although clouds such as California and Orion A have similar masses, they are in very different evolutionary stages, causing their very different observed SFRs and SFEs. The model predicts that the California cloud will eventually reach a significantly larger total mass than the Orion A cloud. Next, we apply the model to derive estimated ages of the clouds since the time when approximately 25% of their mass had become molecular. We find ages from ˜1.5 to 27 Myr, with the most inactive clouds being the youngest. Further predictions of the model are that clouds with very low SFEs should have massive atomic envelopes constituting the majority of their gravitational mass, and that low-mass clouds (M ˜ 103-104M⊙) end their lives with a mini-burst of star formation, reaching SFRs ˜300-500 M⊙ Myr-1. By this time, they have contracted to become compact (˜1 pc) massive star-forming clumps, in general embedded within larger GMCs.

X-rays across the galaxy population - I. Tracing the main sequence of star formation

NASA Astrophysics Data System (ADS)

Aird, J.; Coil, A. L.; Georgakakis, A.

2017-03-01

We use deep Chandra imaging to measure the distribution of X-ray luminosities (LX) for samples of star-forming galaxies as a function of stellar mass and redshift, using a Bayesian method to push below the nominal X-ray detection limits. Our luminosity distributions all show narrow peaks at LX ≲ 1042 erg s-1 that we associate with star formation, as opposed to AGN that are traced by a broad tail to higher LX. Tracking the luminosity of these peaks as a function of stellar mass reveals an 'X-ray main sequence' with a constant slope ≈0.63 ± 0.03 over 8.5 ≲ log {M}_{ast }/M_{⊙} ≲ 11.5 and 0.1 ≲ z ≲ 4, with a normalization that increases with redshift as (1 + z)3.79 ± 0.12. We also compare the peak X-ray luminosities with UV-to-IR tracers of star formation rates (SFRs) to calibrate the scaling between LX and SFR. We find that LX ∝ SFR0.83 × (1 + z)1.3, where the redshift evolution and non-linearity likely reflect changes in high-mass X-ray binary populations of star-forming galaxies. Using galaxies with a broader range of SFR, we also constrain a stellar-mass-dependent contribution to LX, likely related to low-mass X-ray binaries. Using this calibration, we convert our X-ray main sequence to SFRs and measure a star-forming main sequence with a constant slope ≈0.76 ± 0.06 and a normalization that evolves with redshift as (1 + z)2.95 ± 0.33. Based on the X-ray emission, there is no evidence for a break in the main sequence at high stellar masses, although we cannot rule out a turnover given the uncertainties in the scaling of LX to SFR.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan Changshuo; Wang Jianmin, E-mail: wangjm@ihep.ac.c

High spatial resolution observations show that high-redshift galaxies are undergoing intensive evolution of dynamical structure and morphologies displayed by the H{alpha}, H{beta}, [O III], and [N II] images. It has been shown that supernova explosion (SNexp) of young massive stars during the star formation epoch, as kinetic feedback to host galaxies, can efficiently excite the turbulent viscosity. We incorporate the feedback into the dynamical equations through mass dropout and angular momentum transportation driven by the SNexp-excited turbulent viscosity. The empirical Kennicutt-Schmidt law is used for star formation rates (SFRs). We numerically solve the equations and show that there can bemore » intensive evolution of structure of the gaseous disk. Secular evolution of the disk shows interesting characteristics: (1) high viscosity excited by SNexp can efficiently transport the gas from 10 kpc to {approx}1 kpc forming a stellar disk whereas a stellar ring forms for the case with low viscosity; (2) starbursts trigger SMBH activity with a lag of {approx}10{sup 8} yr depending on SFRs, prompting the joint evolution of SMBHs and bulges; and (3) the velocity dispersion is as high as {approx}100 km s{sup -1} in the gaseous disk. These results are likely to vary with the initial mass function (IMF) that the SNexp rates rely on. Given the IMF, we use the GALAXEV code to compute the spectral evolution of stellar populations based on the dynamical structure. In order to compare the present models with the observed dynamical structure and images, we use the incident continuum from the simple stellar synthesis and CLOUDY to calculate emission line ratios of H{alpha}, H{beta}, [O III], and [N II], and H{alpha} brightness of gas photoionized by young massive stars formed on the disks. The models can produce the main features of emission from star-forming galaxies. We apply the present model to two galaxies, BX 389 and BX 482 observed in the SINS high-z sample, which are bulge and disk-dominated, respectively. Two successive rings independently evolving are able to reproduce the main dynamical and emission properties of the two galaxies, such as the Baldwin-Phillips-Terlevich diagram, the relation between line ratios, and H{alpha} brightness. The observed relation between turbulent velocity and the H{alpha} brightness can be explained by the present model. High viscosity excited by SNexp is able to efficiently transport the gas into a bulge to maintain high SFRs or to form a stellar ring close enough to the bulge so that it immigrates into the bulge of its host galaxy. This leads to a fast growing bulge. Implications and future work of the present models have been extensively discussed for galaxy formation in high-z universe.« less

EMBEDDED CLUSTERS IN THE LARGE MAGELLANIC CLOUD USING THE VISTA MAGELLANIC CLOUDS SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romita, Krista; Lada, Elizabeth; Cioni, Maria-Rosa, E-mail: k.a.romita@ufl.edu, E-mail: elada@ufl.edu, E-mail: mcioni@aip.de

We present initial results of the first large-scale survey of embedded star clusters in molecular clouds in the Large Magellanic Cloud (LMC) using near-infrared imaging from the Visible and Infrared Survey Telescope for Astronomy Magellanic Clouds Survey. We explored a ∼1.65 deg{sup 2} area of the LMC, which contains the well-known star-forming region 30 Doradus as well as ∼14% of the galaxy’s CO clouds, and identified 67 embedded cluster candidates, 45 of which are newly discovered as clusters. We have determined the sizes, luminosities, and masses for these embedded clusters, examined the star formation rates (SFRs) of their corresponding molecularmore » clouds, and made a comparison between the LMC and the Milky Way. Our preliminary results indicate that embedded clusters in the LMC are generally larger, more luminous, and more massive than those in the local Milky Way. We also find that the surface densities of both embedded clusters and molecular clouds is ∼3 times higher than in our local environment, the embedded cluster mass surface density is ∼40 times higher, the SFR is ∼20 times higher, and the star formation efficiency is ∼10 times higher. Despite these differences, the SFRs of the LMC molecular clouds are consistent with the SFR scaling law presented in Lada et al. This consistency indicates that while the conditions of embedded cluster formation may vary between environments, the overall process within molecular clouds may be universal.« less

THE FMOS-COSMOS SURVEY OF STAR-FORMING GALAXIES AT z ∼ 1.6. III. SURVEY DESIGN, PERFORMANCE, AND SAMPLE CHARACTERISTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silverman, J. D.; Sugiyama, N.; Kashino, D.

We present a spectroscopic survey of galaxies in the COSMOS field using the Fiber Multi-object Spectrograph (FMOS), a near-infrared instrument on the Subaru Telescope. Our survey is specifically designed to detect the Hα emission line that falls within the H-band (1.6–1.8 μm) spectroscopic window from star-forming galaxies with 1.4 < z < 1.7 and M{sub stellar} ≳ 10{sup 10} M{sub ⊙}. With the high multiplex capability of FMOS, it is now feasible to construct samples of over 1000 galaxies having spectroscopic redshifts at epochs that were previously challenging. The high-resolution mode (R ∼ 2600) effectively separates Hα and [N ii]λ6585,more » thus enabling studies of the gas-phase metallicity and photoionization state of the interstellar medium. The primary aim of our program is to establish how star formation depends on stellar mass and environment, both recognized as drivers of galaxy evolution at lower redshifts. In addition to the main galaxy sample, our target selection places priority on those detected in the far-infrared by Herschel/PACS to assess the level of obscured star formation and investigate, in detail, outliers from the star formation rate (SFR)—stellar mass relation. Galaxies with Hα detections are followed up with FMOS observations at shorter wavelengths using the J-long (1.11–1.35 μm) grating to detect Hβ and [O iii]λ5008 which provides an assessment of the extinction required to measure SFRs not hampered by dust, and an indication of embedded active galactic nuclei. With 460 redshifts measured from 1153 spectra, we assess the performance of the instrument with respect to achieving our goals, discuss inherent biases in the sample, and detail the emission-line properties. Our higher-level data products, including catalogs and spectra, are available to the community.« less

Directly Imaging Damped Ly-Alpha Galaxies at Redshifts Greater Than 2. III: The Star Formation Rates of Neutral Gas Reservoirs at Redshifts of Approximately 2.7

NASA Technical Reports Server (NTRS)

Fumagalli, Michele; OMeara, John M.; Prochaska, J. Xavier; Rafelski, Marc; Kanekar, Nissim

2014-01-01

We present results from a survey designed to probe the star formation properties of 32 damped Ly alpha systems (DLAs) at redshifts of approximately 2.7. By using the "double-DLA" technique that eliminates the glare of the bright background quasars, we directly measure the rest-frame FUV flux from DLAs and their neighbouring galaxies. At the position of the absorbing gas, we place stringent constraints on the unobscured star formation rates (SFRs) of DLAs to 2 sigma limits of psi less than 0.09-0.27 solar mass yr(exp -1), corresponding to SFR surface densities sigma(sub sfr) less than 10(exp -2.6)-10(exp -1.5) solar mass yr(exp -1) kpc(exp -2). The implications of these limits for the star formation law, metal enrichment, and cooling rates of DLAs are examined. By studying the distribution of impact parameters as a function of SFRs for all the galaxies detected around these DLAs, we place new direct constraints on the bright end of the UV luminosity function of DLA hosts. We find that less than or equal to 13% of the hosts have psi greater than or equal to 2 solar mass yr(exp -1) at impact parameters b(sub dla) less than or equal to (psi/solar mass yr(exp -1))(exp 0.8) + 6 kpc, differently from current samples of confirmed DLA galaxies. Our observations also disfavor a scenario in which the majority of DLAs arise from bright LBGs at distances 20 less than or equal to b(sub dla) less than 100 kpc. These new findings corroborate a picture in which DLAs do not originate from highly star forming systems that are coincident with the absorbers, and instead suggest that DLAs are associated with faint, possibly isolated, star-forming galaxies. Potential shortcomings of this scenario and future strategies for further investigation are discussed.

VLA AND ALMA IMAGING OF INTENSE GALAXY-WIDE STAR FORMATION IN z ∼ 2 GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rujopakarn, W.; Silverman, J. D.; Dunlop, J. S.

2016-12-10

We present ≃0.″4 resolution extinction-independent distributions of star formation and dust in 11 star-forming galaxies (SFGs) at z  = 1.3–3.0. These galaxies are selected from sensitive blank-field surveys of the 2′ × 2′ Hubble Ultra-Deep Field at λ  = 5 cm and 1.3 mm using the Karl G. Jansky Very Large Array and Atacama Large Millimeter/submillimeter Array. They have star formation rates (SFRs), stellar masses, and dust properties representative of massive main-sequence SFGs at z  ∼ 2. Morphological classification performed on spatially resolved stellar mass maps indicates a mixture of disk and morphologically disturbed systems; half of the sample harbor X-ray active galactic nuclei (AGNs),more » thereby representing a diversity of z  ∼ 2 SFGs undergoing vigorous mass assembly. We find that their intense star formation most frequently occurs at the location of stellar-mass concentration and extends over an area comparable to their stellar-mass distribution, with a median diameter of 4.2 ± 1.8 kpc. This provides direct evidence of galaxy-wide star formation in distant blank-field-selected main-sequence SFGs. The typical galactic-average SFR surface density is 2.5 M {sub ⊙} yr{sup −1} kpc{sup −2}, sufficiently high to drive outflows. In X-ray-selected AGN where radio emission is enhanced over the level associated with star formation, the radio excess pinpoints the AGNs, which are found to be cospatial with star formation. The median extinction-independent size of main-sequence SFGs is two times larger than those of bright submillimeter galaxies, whose SFRs are 3–8 times larger, providing a constraint on the characteristic SFR (∼300 M {sub ⊙} yr{sup −1}) above which a significant population of more compact SFGs appears to emerge.« less

Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia.

PubMed

Mohammadi, Alireza; Rashidi, Ehsan; Amooeian, Vahid Ghasem

2018-04-13

Over the last decade, finding a reliable biomarker for the early detection of schizophrenia (Scz) has been a topic of interest. The main goal of the current review is to provide a comprehensive view of the brain, blood, cerebrospinal fluid (CSF), and serum biomarkers of Scz disease. Imaging studies have demonstrated that the volumes of the corpus callosum, thalamus, hippocampal formation, subiculum, parahippocampal gyrus, superior temporal gyrus, prefrontal and orbitofrontal cortices, and amygdala-hippocampal complex were reduced in patients diagnosed with Scz. It has been revealed that the levels of interleukin 1β (IL-1β), IL-6, IL-8, and TNF-α were increased in patients with Scz. Decreased mRNA levels of brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), neurotrophin-3 (NT-3), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) genes have also been reported in Scz patients. Genes with known strong relationships with this disease include BDNF, catechol-O-methyltransferase (COMT), regulator of G-protein signaling 4 (RGS4), dystrobrevin-binding protein 1 (DTNBP1), neuregulin 1 (NRG1), Reelin (RELN), Selenium-binding protein 1 (SELENBP1), glutamic acid decarboxylase 67 (GAD 67), and disrupted in schizophrenia 1 (DISC1). The levels of dopamine, tyrosine hydroxylase (TH), serotonin or 5-hydroxytryptamine (5-HT) receptor 1A and B (5-HTR1A and 5-HTR1B), and 5-HT1B were significantly increased in Scz patients, while the levels of gamma-aminobutyric acid (GABA), 5-HT transporter (5-HTT), and 5-HT receptor 2A (5-HTR2A) were decreased. The increased levels of SELENBP1 and Glycogen synthase kinase 3 subunit α (GSK3α) genes in contrast with reduced levels of B-cell translocation gene 1 (BTG1), human leukocyte antigen DRB1 (HLA-DRB1), heterogeneous nuclear ribonucleoprotein A3 (HNRPA3), and serine/arginine-rich splicing factor 1 (SFRS1) genes have also been reported. This review covers various dysregulation of neurotransmitters and also highlights the strengths and weaknesses of studies attempting to identify candidate biomarkers. Copyright © 2018 Elsevier B.V. All rights reserved.

The Quest for Dusty Star-forming Galaxies at High Redshift z ≳ 4

NASA Astrophysics Data System (ADS)

Mancuso, C.; Lapi, A.; Shi, J.; Gonzalez-Nuevo, J.; Aversa, R.; Danese, L.

2016-06-01

We exploit the continuity equation approach and “main-sequence” star formation timescales to show that the observed high abundance of galaxies with stellar masses ≳ a few 1010 M ⊙ at redshift z ≳ 4 implies the existence of a galaxy population featuring large star formation rates (SFRs) ψ ≳ 102 M ⊙ yr-1 in heavily dust-obscured conditions. These galaxies constitute the high-redshift counterparts of the dusty star-forming population already surveyed for z ≲ 3 in the far-IR band by the Herschel Space Observatory. We work out specific predictions for the evolution of the corresponding stellar mass and SFR functions out to z ˜ 10, determining that the number density at z ≲ 8 for SFRs ψ ≳ 30 M ⊙ yr-1 cannot be estimated relying on the UV luminosity function alone, even when standard corrections for dust extinction based on the UV slope are applied. We compute the number counts and redshift distributions (including galaxy-scale gravitational lensing) of this galaxy population, and show that current data from the AzTEC-LABOCA, SCUBA-2, and ALMA-SPT surveys are already addressing it. We demonstrate how an observational strategy based on color preselection in the far-IR or (sub-)millimeter band with Herschel and SCUBA-2, supplemented by photometric data from on-source observations with ALMA, can allow us to reconstruct the bright end of the SFR functions out to z ≲ 8. In parallel, such a challenging task can be managed by exploiting current UV surveys in combination with (sub-)millimeter observations by ALMA and NIKA2 and/or radio observations by SKA and its precursors.

THE QUEST FOR DUSTY STAR-FORMING GALAXIES AT HIGH REDSHIFT z ≳ 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mancuso, C.; Lapi, A.; Shi, J.

2016-06-01

We exploit the continuity equation approach and “main-sequence” star formation timescales to show that the observed high abundance of galaxies with stellar masses ≳ a few 10{sup 10} M {sub ⊙} at redshift z ≳ 4 implies the existence of a galaxy population featuring large star formation rates (SFRs) ψ ≳ 10{sup 2} M {sub ⊙} yr{sup −1} in heavily dust-obscured conditions. These galaxies constitute the high-redshift counterparts of the dusty star-forming population already surveyed for z ≲ 3 in the far-IR band by the Herschel Space Observatory . We work out specific predictions for the evolution of the correspondingmore » stellar mass and SFR functions out to z ∼ 10, determining that the number density at z ≲ 8 for SFRs ψ ≳ 30 M {sub ⊙} yr{sup −1} cannot be estimated relying on the UV luminosity function alone, even when standard corrections for dust extinction based on the UV slope are applied. We compute the number counts and redshift distributions (including galaxy-scale gravitational lensing) of this galaxy population, and show that current data from the AzTEC - LABOCA , SCUBA-2 , and ALMA - SPT surveys are already addressing it. We demonstrate how an observational strategy based on color preselection in the far-IR or (sub-)millimeter band with Herschel and SCUBA-2 , supplemented by photometric data from on-source observations with ALMA , can allow us to reconstruct the bright end of the SFR functions out to z ≲ 8. In parallel, such a challenging task can be managed by exploiting current UV surveys in combination with (sub-)millimeter observations by ALMA and NIKA2 and/or radio observations by SKA and its precursors.« less

Stellar Populations of Highly Magnified Lensed Galaxies: Young Starbursts at Z approximately 2

NASA Technical Reports Server (NTRS)

Wuyts, Eva; Rigby, Jane R.; Gladders, Michael D.; Gilbank, David G.; Sharon, Keren; Gralla, Megan B.; Bayliss, Matthew B.

2012-01-01

We present a comprehensive analysis of the rest-frame UV to near-IR spectral energy distributions (SEDs) and rest-frame optical spectra of four of the brightest gravitationally lensed galaxies in the literature: RCSGA 032727-132609 at z = 1.70, MS1512-cB58 at z = 2.73, SGAS J152745.1+065219 at z = 2.76, and SGAS J122651.3+215220 at z = 2.92. This includes new Spitzer imaging for RCSGA0327 as well as new spectra, near-IR imaging and Spitzer imaging for SGAS1527 and SGAS1226. Lensing magnifications of 3-4 mag allow a detailed study of the stellar populations and physical conditions. We compare star formation rates (SFRs) as measured from the SED fit, the Ha and [O II] ?3727 emission lines, and the UV+IR bolometric luminosity where 24 micron photometry is available. The SFR estimate from the SED fit is consistently higher than the other indicators, which suggests that the Calzetti dust extinction law used in the SED fitting is too flat for young star-forming galaxies at z 2. Our analysis finds similar stellar population parameters for all four lensed galaxies: stellar masses (3-7) ? 10(exp 9)Solar M young ages approx 100 Myr, little dust content E(B - V) = 0.10-0.25, and SFRs around 20-100 solar M/ yr. Compared to typical values for the galaxy population at z approx. 2, this suggests we are looking at newly formed, starbursting systems that have only recently started the buildup of stellar mass. These results constitute the first detailed, uniform analysis of a sample of the growing number of strongly lensed galaxies known at z approx 2.

The star formation history of redshift z ~ 2 galaxies: the role of the infrared prior

NASA Astrophysics Data System (ADS)

Fan, Lu-Lu; Lapi, Andrea; Bressan, Alessandro; Nonino, Mario; De Zotti, Gianfranco; Danese, Luigi

2014-01-01

We build a sample of 298 spectroscopically-confirmed galaxies at redshift z ~ 2, selected in the z850-band from the GOODS-MUSIC catalog. By utilizing the rest frame 8 μm luminosity as a proxy of the star formation rate (SFR), we check the accuracy of the standard SED-fitting technique, finding it is not accurate enough to provide reliable estimates of the physical parameters of galaxies. We then develop a new SED-fitting method that includes the IR luminosity as a prior and a generalized Calzetti law with a variable RV. Then we exploit the new method to re-analyze our galaxy sample, and to robustly determine SFRs, stellar masses and ages. We find that there is a general trend of increasing attenuation with the SFR. Moreover, we find that the SFRs range between a few to 103 Msolar yr-1, the masses from 109 to 4 × 1011 Msolar, and the ages from a few tens of Myr to more than 1 Gyr. We discuss how individual age measurements of highly attenuated objects indicate that dust must have formed within a few tens of Myr and already been copious at <=100 Myr. In addition, we find that low luminosity galaxies harbor, on average, significantly older stellar populations and are also less massive than brighter ones; we discuss how these findings and the well known ‘downsizing’ scenario are consistent in a framework where less massive galaxies form first, but their star formation lasts longer. Finally, we find that the near-IR attenuation is not scarce for luminous objects, contrary to what is customarily assumed; we discuss how this affects the interpretation of the observed M*/L ratios.

Simulating the UV escape fractions from molecular cloud populations in star-forming dwarf and spiral galaxies

NASA Astrophysics Data System (ADS)

Howard, Corey S.; Pudritz, Ralph E.; Harris, William E.; Klessen, Ralf S.

2018-04-01

The escape of ultraviolet photons from the densest regions of the interstellar medium (ISM) - giant molecular clouds (GMCs) - is a poorly constrained parameter which is vital to understanding the ionization of the ISM and the intergalactic medium. We characterize the escape fraction, fesc,GMC, from a suite of individual GMC simulations with masses in the range 104-6 M⊙ using the adaptive-mesh refinement code FLASH. We find significantly different fesc,GMC depending on the GMC mass that can reach >90 per cent in the evolution of 5 × 104 and 105 M⊙ clouds or remain low at ˜5 per cent for most of the lifetime of more massive GMCs. All clouds show fluctuations over short, sub-Myr time-scales produced by flickering H II regions. We combine our results to calculate the total escape fraction (fesc,tot) from GMC populations in dwarf starburst and spiral galaxies by randomly drawing clouds from a GMC mass distribution (dN/dM ∝ Mα, where α is either -1.5 or -2.5) over fixed time intervals. We find typical fesc,tot values of 8 per cent for both the dwarf and spiral models. The fluctuations of fesc,tot, however, are much larger for the dwarf models with values as high as 90 per cent. The photons escaping from the 5 × 104 and 105 M⊙ GMCs are the dominant contributors to fesc,tot in all cases. We also show that the accompanying star formation rates (SFRs) of our model (˜2 × 10-2 and 0.73 M⊙yr-1) are consistent with observations of SFRs in dwarf starburst and spiral galaxies, respectively.

Identifying the subtle signatures of feedback from distant AGN using ALMA observations and the EAGLE hydrodynamical simulations

NASA Astrophysics Data System (ADS)

Scholtz, J.; Alexander, D. M.; Harrison, C. M.; Rosario, D. J.; McAlpine, S.; Mullaney, J. R.; Stanley, F.; Simpson, J.; Theuns, T.; Bower, R. G.; Hickox, R. C.; Santini, P.; Swinbank, A. M.

2018-03-01

We present sensitive 870 μm continuum measurements from our ALMA programmes of 114 X-ray selected active galactic nuclei (AGN) in the Chandra Deep Field-South and Cosmic Evolution Survey fields. We use these observations in combination with data from Spitzer and Herschel to construct a sample of 86 X-ray selected AGN, 63 with ALMA constraints at z = 1.5-3.2 with stellar mass >2 × 1010 M⊙. We constructed broad-band spectral energy distributions in the infrared band (8-1000 μm) and constrain star-formation rates (SFRs) uncontaminated by the AGN. Using a hierarchical Bayesian method that takes into account the information from upper limits, we fit SFR and specific SFR (sSFR) distributions. We explore these distributions as a function of both X-ray luminosity and stellar mass. We compare our measurements to two versions of the Evolution and Assembly of GaLaxies and their Environments (EAGLE) hydrodynamical simulations: the reference model with AGN feedback and the model without AGN. We find good agreement between the observations and that predicted by the EAGLE reference model for the modes and widths of the sSFR distributions as a function of both X-ray luminosity and stellar mass; however, we found that the EAGLE model without AGN feedback predicts a significantly narrower width when compared to the data. Overall, from the combination of the observations with the model predictions, we conclude that (1) even with AGN feedback, we expect no strong relationship between the sSFR distribution parameters and instantaneous AGN luminosity and (2) a signature of AGN feedback is a broad distribution of sSFRs for all galaxies (not just those hosting an AGN) with stellar masses above ≈1010 M⊙.

THE MULTI-WAVELENGTH EXTREME STARBURST SAMPLE OF LUMINOUS GALAXIES. I. SAMPLE CHARACTERISTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laag, Edward; Croft, Steve; Canalizo, Gabriela

2010-12-15

This paper introduces the Multi-wavelength Extreme Starburst Sample (MESS), a new catalog of 138 star-forming galaxies (0.1 < z < 0.3) optically selected from the Sloan Digital Sky Survey using emission line strength diagnostics to have a high absolute star formation rate (SFR; minimum 11 M{sub sun} yr{sup -1} with median SFR {approx} 61 M{sub sun} yr{sup -1} based on a Kroupa initial mass function). The MESS was designed to complement samples of nearby star-forming galaxies such as the luminous infrared galaxies (LIRGs) and ultraviolet luminous galaxies (UVLGs). Observations using the Multi-band Imaging Photometer (24, 70, and 160 {mu}m channels)more » on the Spitzer Space Telescope indicate that the MESS galaxies have IR luminosities similar to those of LIRGs, with an estimated median L{sub TIR} {approx} 3 x 10{sup 11} L{sub sun}. The selection criteria for the MESS objects suggest they may be less obscured than typical far-IR-selected galaxies with similar estimated SFRs. Twenty out of 70 of the MESS objects detected in the Galaxy Evolution Explorer FUV band also appear to be UVLGs. We estimate the SFRs based directly on luminosities to determine the agreement for these methods in the MESS. We compare these estimates to the emission line strength technique, since the effective measurement of dust attenuation plays a central role in these methods. We apply an image stacking technique to the Very Large Array FIRST survey radio data to retrieve 1.4 GHz luminosity information for 3/4 of the sample covered by FIRST including sources too faint, and at too high a redshift, to be detected in FIRST. We also discuss the relationship between the MESS objects and samples selected through alternative criteria. Morphologies will be the subject of a forthcoming paper.« less

Direct Measurement of Dust Attenuation in z approx. 1.5 Star-Forming Galaxies from 3D-HST: Implications for Dust Geometry and Star Formation Rates

NASA Technical Reports Server (NTRS)

Price, Sedona H.; Kriek, Mariska; Brammer, Gabriel B; Conroy, Charlie; Schreiber, Natascha M. Foerster; Franx, Marijn; Fumagalli, Mattia; Lundren, Britt; Momcheva, Ivelina; Nelson, Erica J.;

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.

PubMed

French, Juliet D; Johnatty, Sharon E; Lu, Yi; Beesley, Jonathan; Gao, Bo; Kalimutho, Murugan; Henderson, Michelle J; Russell, Amanda J; Kar, Siddhartha; Chen, Xiaoqing; Hillman, Kristine M; Kaufmann, Susanne; Sivakumaran, Haran; O'Reilly, Martin; Wang, Chen; Korbie, Darren J; Lambrechts, Diether; Despierre, Evelyn; Van Nieuwenhuysen, Els; Lambrechts, Sandrina; Vergote, Ignace; Karlan, Beth; Lester, Jenny; Orsulic, Sandra; Walsh, Christine; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Hein, Alexander; Matsuo, Keitaro; Hosono, Satoyo; Pisterer, Jacobus; Hillemanns, Peter; Nakanishi, Toru; Yatabe, Yasushi; Goodman, Marc T; Lurie, Galina; Matsuno, Rayna K; Thompson, Pamela J; Pejovic, Tanja; Bean, Yukie; Heitz, Florian; Harter, Philipp; du Bois, Andreas; Schwaab, Ira; Hogdall, Estrid; Kjaer, Susanne K; Jensen, Allan; Hogdall, Claus; Lundvall, Lene; Engelholm, Svend Aage; Brown, Bob; Flanagan, James M; Metcalf, Michelle D; Siddiqui, Nadeem; Sellers, Thomas; Fridley, Brooke; Cunningham, Julie; Schildkraut, Joellen M; Iversen, Ed; Weber, Rachel Palmieri; Brennan, Donal; Berchuck, Andrew; Pharoah, Paul; Harnett, Paul; Norris, Murray D; Haber, Michelle; Goode, Ellen L; Lee, Jason S; Khanna, Kum Kum; Meyer, Kerstin B; Chenevix-Trench, Georgia; deFazio, Anna; Edwards, Stacey L; MacGregor, Stuart

2016-02-09

Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable inter-individual variation in response. To identify germline single-nucleotide polymorphisms (SNPs) that contribute to variations in individual responses to chemotherapy, we carried out a multi-phase genome-wide association study (GWAS) in 1,244 women diagnosed with serous EOC who were treated with the same first-line chemotherapy, carboplatin and paclitaxel. We identified two SNPs (rs7874043 and rs72700653) in TTC39B (best P=7x10-5, HR=1.90, for rs7874043) associated with progression-free survival (PFS). Functional analyses show that both SNPs lie in a putative regulatory element (PRE) that physically interacts with the promoters of PSIP1, CCDC171 and an alternative promoter of TTC39B. The C allele of rs7874043 is associated with poor PFS and showed increased binding of the Sp1 transcription factor, which is critical for chromatin interactions with PSIP1. Silencing of PSIP1 significantly impaired DNA damage-induced Rad51 nuclear foci and reduced cell viability in ovarian cancer lines. PSIP1 (PC4 and SFRS1 Interacting Protein 1) is known to protect cells from stress-induced apoptosis, and high expression is associated with poor PFS in EOC patients. We therefore suggest that the minor allele of rs7874043 confers poor PFS by increasing PSIP1 expression.

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

PubMed Central

French, Juliet D.; Johnatty, Sharon E.; Lu, Yi; Beesley, Jonathan; Gao, Bo; Kalimutho, Murugan; Henderson, Michelle J.; Russell, Amanda J.; Kar, Siddhartha; Chen, Xiaoqing; Hillman, Kristine M.; Kaufmann, Susanne; Sivakumaran, Haran; O'Reilly, Martin; Wang, Chen; Korbie, Darren J.; Lambrechts, Diether; Despierre, Evelyn; Van Nieuwenhuysen, Els; Lambrechts, Sandrina; Vergote, Ignace; Karlan, Beth; Lester, Jenny; Orsulic, Sandra; Walsh, Christine; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Hein, Alexander; Matsuo, Keitaro; Hosono, Satoyo; Pisterer, Jacobus; Hillemanns, Peter; Nakanishi, Toru; Yatabe, Yasushi; Goodman, Marc T.; Lurie, Galina; Matsuno, Rayna K.; Thompson, Pamela J.; Pejovic, Tanja; Bean, Yukie; Heitz, Florian; Harter, Philipp; du Bois, Andreas; Schwaab, Ira; Hogdall, Estrid; Kjaer, Susanne K.; Jensen, Allan; Hogdall, Claus; Lundvall, Lene; Engelholm, Svend Aage; Brown, Bob; Flanagan, James M.; Metcalf, Michelle D.; Siddiqui, Nadeem; Sellers, Thomas; Fridley, Brooke; Cunningham, Julie; Schildkraut, Joellen M.; Iversen, Ed; Weber, Rachel Palmieri; Brennan, Donal; Berchuck, Andrew; Pharoah, Paul; Harnett, Paul; Norris, Murray D.; Haber, Michelle; Goode, Ellen L.; Lee, Jason S.; Khanna, Kum Kum; Meyer, Kerstin B.; Chenevix-Trench, Georgia; deFazio, Anna; Edwards, Stacey L.; MacGregor, Stuart

2016-01-01

Women with epithelial ovarian cancer (EOC) are usually treated with platinum/taxane therapy after cytoreductive surgery but there is considerable inter-individual variation in response. To identify germline single-nucleotide polymorphisms (SNPs) that contribute to variations in individual responses to chemotherapy, we carried out a multi-phase genome-wide association study (GWAS) in 1,244 women diagnosed with serous EOC who were treated with the same first-line chemotherapy, carboplatin and paclitaxel. We identified two SNPs (rs7874043 and rs72700653) in TTC39B (best P=7×10−5, HR=1.90, for rs7874043) associated with progression-free survival (PFS). Functional analyses show that both SNPs lie in a putative regulatory element (PRE) that physically interacts with the promoters of PSIP1, CCDC171 and an alternative promoter of TTC39B. The C allele of rs7874043 is associated with poor PFS and showed increased binding of the Sp1 transcription factor, which is critical for chromatin interactions with PSIP1. Silencing of PSIP1 significantly impaired DNA damage-induced Rad51 nuclear foci and reduced cell viability in ovarian cancer lines. PSIP1 (PC4 and SFRS1 Interacting Protein 1) is known to protect cells from stress-induced apoptosis, and high expression is associated with poor PFS in EOC patients. We therefore suggest that the minor allele of rs7874043 confers poor PFS by increasing PSIP1 expression. PMID:26840454

ALMA Imaging of Gas and Dust in a Galaxy Protocluster at Redshift 5.3: [C II] Emission in "Typical" Galaxies and Dusty Starbursts ≈1 Billion Years after the Big Bang

NASA Astrophysics Data System (ADS)

Riechers, Dominik A.; Carilli, Christopher L.; Capak, Peter L.; Scoville, Nicholas Z.; Smolčić, Vernesa; Schinnerer, Eva; Yun, Min; Cox, Pierre; Bertoldi, Frank; Karim, Alexander; Yan, Lin

2014-12-01

We report interferometric imaging of [C II](2 P 3/2→2 P 1/2) and OH(2Π1/2 J = 3/2→1/2) emission toward the center of the galaxy protocluster associated with the z = 5.3 submillimeter galaxy (SMG) AzTEC-3, using the Atacama Large (sub)Millimeter Array (ALMA). We detect strong [C II], OH, and rest-frame 157.7 μm continuum emission toward the SMG. The [C II](2 P 3/2→2 P 1/2) emission is distributed over a scale of 3.9 kpc, implying a dynamical mass of 9.7 × 1010 M ⊙, and a star formation rate (SFR) surface density of ΣSFR = 530 M ⊙ yr-1 kpc-2. This suggests that AzTEC-3 forms stars at ΣSFR approaching the Eddington limit for radiation pressure supported disks. We find that the OH emission is slightly blueshifted relative to the [C II] line, which may indicate a molecular outflow associated with the peak phase of the starburst. We also detect and dynamically resolve [C II](2 P 3/2→2 P 1/2) emission over a scale of 7.5 kpc toward a triplet of Lyman-break galaxies with moderate UV-based SFRs in the protocluster at ~95 kpc projected distance from the SMG. These galaxies are not detected in the continuum, suggesting far-infrared SFRs of <18-54 M ⊙ yr-1, consistent with a UV-based estimate of 22 M ⊙ yr-1. The spectral energy distribution of these galaxies is inconsistent with nearby spiral and starburst galaxies, but resembles those of dwarf galaxies. This is consistent with expectations for young starbursts without significant older stellar populations. This suggests that these galaxies are significantly metal-enriched, but not heavily dust-obscured, "normal" star-forming galaxies at z > 5, showing that ALMA can detect the interstellar medium in "typical" galaxies in the very early universe.

Worldwide Use of Antiretropulsive Techniques: Observations from the Clinical Research Office of the Endourological Society Ureteroscopy Global Study.

PubMed

Saussine, Christian; Andonian, Sero; Pacík, Dalibor; Popiolek, Marcin; Celia, Antonio; Buchholz, Noor; Sountoulides, Petros; Petrut, Bogdan; de la Rosette, Jean J M C H

2018-04-01

Retropulsion, defined as unintended migration of a stone under the influence of the fragmentation device in ureteroscopy (URS) procedures, occurs in 2% to 60% of the cases. Antiretropulsive devices (ARDs) have been studied in experimental and small clinical studies. The current study aims at describing the worldwide usage of ARD and the outcomes related to their usage. The Clinical Research Office of the Endourological Society URS Global Study enrolled 11,885 patients who underwent URS and stone fragmentation for ureteral and/or renal stones. Of the 11,885 treated patients, 9877 were treated for ureteral stones, and data were available on stone migration and ARD use. Of all procedures, 14.5% were performed with the use of an ARD. Less stone migration (-2.0%; p = 0.050), higher stone-free rates (SFRs) (2.8%; p < 0.001), and shorter length of stay (-4.7%; p = 0.001) were observed in the antiretropulsive group. When an ARD is used during URS, less migration, higher SFRs, and shorter length of hospital stay are observed. This effect is independent from baseline differences and corrected for other treatment characteristics.

NEAR-INFRARED ADAPTIVE OPTICS IMAGING OF INFRARED LUMINOUS GALAXIES: THE BRIGHTEST CLUSTER MAGNITUDE-STAR FORMATION RATE RELATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Randriamanakoto, Z.; Väisänen, P.; Escala, A.

2013-10-01

We have established a relation between the brightest super star cluster (SSC) magnitude in a galaxy and the host star formation rate (SFR) for the first time in the near-infrared (NIR). The data come from a statistical sample of ∼40 luminous IR galaxies (LIRGs) and starbursts utilizing K-band adaptive optics imaging. While expanding the observed relation to longer wavelengths, less affected by extinction effects, it also pushes to higher SFRs. The relation we find, M{sub K} ∼ –2.6log SFR, is similar to that derived previously in the optical and at lower SFRs. It does not, however, fit the optical relationmore » with a single optical to NIR color conversion, suggesting systematic extinction and/or age effects. While the relation is broadly consistent with a size-of-sample explanation, we argue physical reasons for the relation are likely as well. In particular, the scatter in the relation is smaller than expected from pure random sampling strongly suggesting physical constraints. We also derive a quantifiable relation tying together cluster-internal effects and host SFR properties to possibly explain the observed brightest SSC magnitude versus SFR dependency.« less

STAR FORMATION ACTIVITY IN A YOUNG GALAXY CLUSTER AT Z = 0.866

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laganá, T. F.; Martins, L. P.; Ulmer, M. P.

2016-07-10

The galaxy cluster RX J1257+4738 at z = 0.866 is one of the highest redshift clusters with a richness of multi-wavelength data, and is thus a good target to study the star formation–density relation at early epochs. Using a sample of spectroscopically confirmed cluster members, we derive the star-formation rates (SFRs) of our galaxies using two methods: (1) the relation between SFR and total infrared luminosity extrapolated from the observed Spitzer Multiband Imaging Photometer for Spitzer 24 μ m imaging data; and (2) spectral energy distribution fitting using the MAGPHYS code, including eight different bands. We show that, for thismore » cluster, the SFR–density relation is very weak and seems to be dominated by the two central galaxies and the SFR presents a mild dependence on stellar mass, with more massive galaxies having higher SFR. However, the specific SFR (SSFR) decreases with stellar mass, meaning that more massive galaxies are forming fewer stars per unit of mass, and thus suggesting that the increase in star-forming members is driven by cluster assembly and infall. If the environment is somehow driving the star formation, one would expect a relation between the SSFR and the cluster centric distance, but that is not the case. A possible scenario to explain this lack of correlation is the contamination by infalling galaxies in the inner part of the cluster, which may be on their initial pass through the cluster center. As these galaxies have higher SFRs for their stellar mass, they enhance the mean SSFR in the center of the cluster.« less

Soret forced Rayleigh scattering instrument for simultaneous detection of two-wavelength signals to measure Soret coefficient and thermodiffusion coefficient in ternary mixtures

NASA Astrophysics Data System (ADS)

Matsuura, H.; Nagasaka, Y.

2018-02-01

We describe an instrument for the measurement of the Soret and thermodiffusion coefficients in ternary systems based on the transient holographic grating technique, which is called Soret forced Rayleigh scattering (SFRS) or thermal diffusion forced Rayleigh scattering (TDFRS). We integrated the SFRS technique and the two-wavelength detection technique, which enabled us to obtain two different signals to determine the two independent Soret coefficients and thermodiffusion coefficients in ternary systems. The instrument has been designed to read the mass transport simultaneously by two-wavelength lasers with wavelengths of λ = 403 nm and λ = 639 nm. The irradiation time of the probing lasers is controlled to reduce the effect of laser absorption to the sample with dye (quinizarin), which is added to convert the interference pattern of the heating laser of λ = 532 nm to the temperature grating. The result of the measurement of binary benchmark mixtures composed of 1,2,3,4-tetrahydronaphthalene (THN), isobutylbenzene (IBB), and n-dodecane (nC12) shows that the simultaneous two-wavelength observation of the Soret effect and the mass diffusion are adequately performed. To evaluate performance in the measurement of ternary systems, we carried out experiments on the ternary benchmark mixtures of THN/IBB/nC12 with the mass fractions of 0.800/0.100/0.100 at a temperature of 298.2 K. The Soret coefficient and thermodiffusion coefficient agreed with the ternary benchmark values within the range of the standard uncertainties (23% for the Soret coefficient of THN and 30% for the thermodiffusion coefficient of THN).

Surgical management of urinary stones with abnormal kidney anatomy.

PubMed

Ergin, Giray; Kirac, Mustafa; Unsal, Ali; Kopru, Burak; Yordam, Mustafa; Biri, Hasan

2017-04-01

In spite of the fact that urologic surgical techniques used by urologists are becoming more and more minimally invasive and easier because of developing technologies, surgical approaches for the urinary stones in kidneys with abnormal anatomy are still confusing. The objective of this article is to determine the treatment options in these kidneys. For this purpose, between 2005 and 2015, we retrospectively evaluated patients operated for urolithiasis with various congenital renal anomalies in five referral urology clinics in our country. Of the 178 patients (110 male, 60 female), 96 had horseshoe kidneys, 42 had pelvic ectopic kidneys (PEKs), and 40 had isolated rotation anomalies (IRAs) of the kidney. We evaluated the patients for stone-free rate (SFR), mean operation time, mean hospitalization time, and complication rate. In horseshoe kidney, SFRs for retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PNL) groups were 72.2% and 90%, respectively. In PEKs, these rates were 83.6% and 100% for RIRS and laparoscopic pyelolithotomy, respectively. SFRs in kidneys with IRA were 75% for RIRS and 83.3% for PNL. The mean operation time for RIRS and PNL groups in horseshoe kidney was 40.5±11.2 minutes and 74.5±19.3 minutes, respectively. In PEKs, these times were 52.1±19.3 minutes and 53.1±24.3 minutes for RIRS and laparoscopic pyelolithotomy, respectively. Mean operation time in kidneys with IRA was 48.7±14.4 minutes for RIRS and 53.2±11.3 minutes for PNL. Mean hospitalization times for RIRS and PNL groups in horseshoe kidneys were 1.4±0.7 days and 2.2±1.4 days, respectively. In PEKs, these times were 2.7±1.8 days and 1.9±0.4 days for RIRS and laparoscopic pyelolithotomy, respectively. Mean operation time in kidneys with IRA was 1.5±0.9 days for RIRS and 1.8±0.6 days for PNL. The results of our study showed that RIRS could be used in all of types of abnormal kidneys with small- and medium-sized renal calculi safely and satisfactorily. Copyright © 2017. Published by Elsevier Taiwan.

Dust Attenuation, Bulge Formation, and Inside-out Quenching of Star Formation in Star-forming Main Sequence Galaxies at z ∼ 2

NASA Astrophysics Data System (ADS)

Tacchella, S.; Carollo, C. M.; Förster Schreiber, N. M.; Renzini, A.; Dekel, A.; Genzel, R.; Lang, P.; Lilly, S. J.; Mancini, C.; Onodera, M.; Tacconi, L. J.; Wuyts, S.; Zamorani, G.

2018-05-01

We derive 2D dust attenuation maps at ∼1 kpc resolution from the UV continuum for 10 galaxies on the z ∼ 2 star-forming main sequence (SFMS). Comparison with IR data shows that 9 out of 10 galaxies do not require further obscuration in addition to the UV-based correction, though our sample does not include the most heavily obscured, massive galaxies. The individual rest-frame V-band dust attenuation (A V) radial profiles scatter around an average profile that gently decreases from ∼1.8 mag in the center down to ∼0.6 mag at ∼3–4 half-mass radii. We use these maps to correct UV- and Hα-based star formation rates (SFRs), which agree with each other. At masses ≲ {10}11 {M}ȯ , the dust-corrected specific SFR (sSFR) profiles are on average radially constant at a mass-doubling timescale of ∼300 Myr, pointing at a synchronous growth of bulge and disk components. At masses ≳ {10}11 {M}ȯ , the sSFR profiles are typically centrally suppressed by a factor of ∼10 relative to the galaxy outskirts. With total central obscuration disfavored, this indicates that at least a fraction of massive z ∼ 2 SFMS galaxies have started their inside-out star formation quenching that will move them to the quenched sequence. In combination with other observations, galaxies above and below the ridge of the SFMS relation have, respectively, centrally enhanced and centrally suppressed sSFRs relative to their outskirts, supporting a picture where bulges are built owing to gas “compaction” that leads to a high central SFR as galaxies move toward the upper envelope of the SFMS. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated under NASA contract NAS 5‑26555 (programs GO9822, GO10092, GO10924, GO11694, GO12578, GO12060, GO12061, GO12062, GO12063, GO12064, GO12440, GO12442, GO12443, GO12444, GO12445, GO13669), and at the Very Large Telescope of the European Southern Observatory, Paranal, Chile (ESO Programme IDs 075.A-0466, 076.A-0527, 079.A-0341, 080.A-0330, 080.A-0339, 080.A-0635, 081.A-0672, 183.A-0781, 087.A-0081, 088.A-0202, 088.A-0209, 091.A-0126).

Multi-Wavelength Analysis of Active Galactic Nuclei and Host Galaxies Physical Properties

NASA Astrophysics Data System (ADS)

Azadi, Mojegan

In this dissertation we study the properties of active galactic nuclei (AGN), which are powered by the accretion activity of supermassive black holes residing at the centers of galaxies. While observations propose that growth of AGN and galaxies are globally tied, we investigate whether this connection exists in individual galaxies. We also investigate various AGN selection techniques and star formation rate (SFR) estimates using multi-wavelength data from Chandra, Spitzer and rest-frame optical spectra from the Keck telescope. We find that combining multi-wavelength identification techniques provides a more complete AGN sample, as each selection method suffers from selection biases. In particular, all selection techniques are biased against identifying AGN in lower mass galaxies. Once stellar mass selection biases are taken into account, we find that AGN reside in galaxies with similar physical properties (i.e., SFR) as inactive galaxies. We find that while AGN are prevalent in both star-forming and quiescent galaxies, AGN of a given accretion rate are more likely to reside in star-forming galaxies. The probability of fueling an AGN does not strongly depend on SFR for a star-forming galaxy, though it decreases when star formation is shut down in quiescent galaxies. We also find no evidence for a strong correlation between SFR or stellar mass of the host galaxy and AGN luminosity. These results indicate that while both AGN and galaxy growth are reliant on the same fuel, enhanced star formation activity does not necessarily go hand-in-hand with increased AGN activity. While the star formation activity of galaxies can be traced with various indicators, our investigations indicate that extrapolations from mid-infrared data using calibrations based on local galaxies overestimates SFRs at higher redshift. We show that a combina- tion of mid-infrared and far-infrared data provide a more reliable SFR estimation than the mid-infrared data alone. We also find that the robustness of UV-based SFRs depends on the extinction correction method used. We find a relatively small fraction of z 2 galaxies have SFRs from infrared observations that are elevated relative to other SFR tracers, and we do not find any contribution from AGN in this excess.

X-ray detections of submillimetre galaxies: active galactic nuclei versus starburst contribution

NASA Astrophysics Data System (ADS)

Johnson, S. P.; Wilson, G. W.; Wang, Q. D.; Williams, C. C.; Scott, K. S.; Yun, M. S.; Pope, A.; Lowenthal, J.; Aretxaga, I.; Hughes, D.; Kim, M. J.; Kim, S.; Tamura, Y.; Kohno, K.; Ezawa, H.; Kawabe, R.; Oshima, T.

2013-05-01

We present a large-scale study of the X-ray properties and near-IR-to-radio spectral energy distributions (SEDs) of submillimetre galaxies (SMGs) detected at 1.1 mm with the AzTEC instrument across a ˜1.2 square degree area of the sky. Combining deep 2-4 Ms Chandra data with Spitzer IRAC/MIPS and Very Large Array data within the Great Observatories Origins Deep Survey North (GOODS-N), GOODS-S and COSMOS fields, we find evidence for active galactic nucleus (AGN) activity in ˜14 per cent of 271 AzTEC SMGs, ˜28 per cent considering only the two GOODS fields. Through X-ray spectral modelling and multiwavelength SED fitting using Monte Carlo Markov chain techniques to Siebenmorgen et al. (AGN) and Efstathiou, Rowan-Robinson & Siebenmorgen (starburst) templates, we find that while star formation dominates the IR emission, with star formation rates (SFRs) ˜100-1000 M⊙ yr-1, the X-ray emission for most sources is almost exclusively from obscured AGNs, with column densities in excess of 1023 cm-2. Only for ˜6 per cent of our sources do we find an X-ray-derived SFR consistent with NIR-to-radio SED derived SFRs. Inclusion of the X-ray luminosities as a prior to the NIR-to-radio SED effectively sets the AGN luminosity and SFR, preventing significant contribution from the AGN template. Our SED modelling further shows that the AGN and starburst templates typically lack the required 1.1 mm emission necessary to match observations, arguing for an extended, cool dust component. The cross-correlation function between the full samples of X-ray sources and SMGs in these fields does not indicate a strong correlation between the two populations at large scales, suggesting that SMGs and AGNs do not necessarily trace the same underlying large-scale structure. Combined with the remaining X-ray-dim SMGs, this suggests that sub-mm-bright sources may evolve along multiple tracks, with X-ray-detected SMGs representing transitionary objects between periods of high star formation and AGN activity, while X-ray-faint SMGs represent a brief starburst phase of more normal galaxies.

VizieR Online Data Catalog: Circumnuclear star-forming regions (Alvarez-Alvarez+, 2015)

NASA Astrophysics Data System (ADS)

Alvarez-Alvarez, M.; Diaz, A. I.; Terlevich, E.; Terlevich, R.

2016-01-01

In order to achieve our scientific goals, we have studied a diverse population of galaxies with reported circumnuclear rings of SFRs in the bibliography. The data were acquired during five observing runs. For the first two runs (from 1988 to 1990), we used a blue sensitive GEC CCD at the f/15 Cassegrain focus of the 1.0m. Jacobus Kaptein Telescope of the Isaac Newton Group at the Observatorio del Roque de los Muchachos, La Palma, Spain. The CCD had 578x385 pixels 22um wide. The last three observing runs were carried on from 1999 to 2000 at the Centro Astronomico Hispano Aleman de Calar Alto, Almeria, Spain. (3 data files).

Deep Near-Infrared Surveys and Young Brown Dwarf Populations in Star-Forming Regions

NASA Astrophysics Data System (ADS)

Tamura, M.; Naoi, T.; Oasa, Y.; Nakajima, Y.; Nagashima, C.; Nagayama, T.; Baba, D.; Nagata, T.; Sato, S.; Kato, D.; Kurita, M.; Sugitani, K.; Itoh, Y.; Nakaya, H.; Pickles, A.

2003-06-01

We are currently conducting three kinds of IR surveys of star forming regions (SFRs) in order to seek for very low-mass young stellar populations. First is a deep JHKs-bands (simultaneous) survey with the SIRIUS camera on the IRSF 1.4m or the UH 2.2m telescopes. Second is a very deep JHKs survey with the CISCO IR camera on the Subaru 8.2m telescope. Third is a high resolution companion search around nearby YSOs with the CIAO adaptive optics coronagraph IR camera on the Subaru. In this contribution, we describe our SIRIUS camera and present preliminary results of the ongoing surveys with this new instrument.

Hα Imaging of Nearby Seyfert Host Galaxies

NASA Astrophysics Data System (ADS)

Theios, Rachel L.; Malkan, Matthew A.; Ross, Nathaniel R.

2016-05-01

We used narrowband (Δλ = 70 Å) interference filters with the CCD imaging camera on the Nickel 1.0 m telescope at Lick Observatory to observe 31 nearby (z < 0.03) Seyfert galaxies in the 12 μm active galaxy sample. We obtained pure emission-line images of each galaxy, which reach down to a flux limit of 7.3 × 10-15 erg cm-2 s-1 arcsec-2, and corrected these images for [N II] emission and extinction. We separated the Hα emission line of the “nucleus” (central 100-1000 pc) from that of the host galaxy. The extended Hα emission is expected to be powered by newly formed hot stars, and indeed correlates well with other indicators of current star formation rates (SFRs) in these galaxies: extended 7.7 μm polycyclic aromatic hydrocarbon, total far-infrared, and radio luminosity. Relative to what would be expected from recent star formation, there is a 0.8 dex excess of radio emission in our Seyfert galaxies. The Hα luminosity we measured in the centers of our galaxies is dominated by the active galactic nucleus (AGN), and is linearly correlated with the hard X-ray luminosity. There is, however, an upward offset of 1 dex in this correlation for the Seyfert 1s, because their nuclear Hα emission includes a strong additional contribution from the broad-line region. We found a correlation between SFR and AGN luminosity. In spite of selection effects, we concluded that the absence of bright Seyfert nuclei in galaxies with low SFRs is real, albeit only weakly significant. Finally, we used our measured spatial distributions of Hα emission to determine what these Seyfert galaxies would look like when observed through fixed apertures (e.g., a spectroscopic fiber) at high redshifts. We found that although all of these Seyfert galaxies would be detectable emission-line galaxies at any redshift, most of them would appear to be dominated by (>67%) their H II region emission. Only the most luminous AGNs (log(L Hα /erg s-1) > 41.5) would still be identified as such at z ˜ 0.3.

THE BURSTY STAR FORMATION HISTORIES OF LOW-MASS GALAXIES AT 0.4 < z < 1 REVEALED BY STAR FORMATION RATES MEASURED FROM H β AND FUV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Yicheng; Faber, S. M.; Koo, David C.

2016-12-10

We investigate the burstiness of star formation histories (SFHs) of galaxies at 0.4 <  z  < 1 by using the ratio of star formation rates (SFRs) measured from H β and FUV (1500 Å) (H β -to-FUV ratio). Our sample contains 164 galaxies down to stellar mass ( M {sub *}) of 10{sup 8.5} M {sub ⊙} in the CANDELS GOODS-N region, where Team Keck Redshift Survey Keck/DEIMOS spectroscopy and Hubble Space Telescope /WFC3 F275W images from CANDELS and Hubble Deep UV Legacy Survey are available. When the ratio of H β - and FUV-derived SFRs is measured, dust extinction correction ismore » negligible (except for very dusty galaxies) with the Calzetti attenuation curve. The H β -to-FUV ratio of our sample increases with M {sub *} and SFR. The median ratio is ∼0.7 at M {sub *} ∼ 10{sup 8.5} M {sub ⊙} (or SFR ∼ 0.5 M {sub ⊙} yr{sup −1}) and increases to ∼1 at M {sub *} ∼ 10{sup 10} M {sub ⊙} (or SFR ∼ 10 M {sub ⊙} yr{sup −1}). At M {sub *} < 10{sup 9.5} M {sub ⊙}, our median H β -to-FUV ratio is lower than that of local galaxies at the same M {sub *}, implying a redshift evolution. Bursty SFH on a timescale of a few tens of megayears on galactic scales provides a plausible explanation for our results, and the importance of the burstiness increases as M {sub *} decreases. Due to sample selection effects, our H β -to-FUV ratio may be an upper limit of the true value of a complete sample, which strengthens our conclusions. Other models, e.g., non-universal initial mass function or stochastic star formation on star cluster scales, are unable to plausibly explain our results.« less

The MUSE Hubble Ultra Deep Field Survey. VII. Fe II* emission in star-forming galaxies

NASA Astrophysics Data System (ADS)

Finley, Hayley; Bouché, Nicolas; Contini, Thierry; Paalvast, Mieke; Boogaard, Leindert; Maseda, Michael; Bacon, Roland; Blaizot, Jérémy; Brinchmann, Jarle; Epinat, Benoît; Feltre, Anna; Marino, Raffaella Anna; Muzahid, Sowgat; Richard, Johan; Schaye, Joop; Verhamme, Anne; Weilbacher, Peter M.; Wisotzki, Lutz

2017-11-01

Non-resonant Fe II* (λ2365, λ2396, λ2612, λ2626) emission can potentially trace galactic winds in emission and provide useful constraints to wind models. From the 3.15' × 3.15' mosaic of the Hubble Ultra Deep Field (UDF) obtained with the VLT/MUSE integral field spectrograph, we identify a statistical sample of 40 Fe II* emitters and 50 MgIII (λλ2796,2803) emitters from a sample of 271 [O II]λλ3726,3729 emitters with reliable redshifts from z = 0.85-1.50 down to 2 × 10-18 (3σ) ergs s-1 cm-2 (for [O II]), covering the M⋆ range from 108-1011 M⊙. The Fe II* and Mg II emitters follow the galaxy main sequence, but with a clear dichotomy. Galaxies with masses below 109 M⊙ and star formation rates (SFRs) of ≲ 1 M⊙ yr-1 have MgIII emission without accompanying Fe II* emission, whereas galaxies with masses above 1010 M⊙ and SFRs ≳ 10 M⊙ yr-1 have Fe II* emission without accompanying MgIII emission. Between these two regimes, galaxies have both MgIII and Fe II* emission, typically with MgIII P Cygni profiles. Indeed, the MgIII profile shows a progression along the main sequence from pure emission to P Cygni profiles to strong absorption, due to resonant trapping. Combining the deep MUSE data with HST ancillary information, we find that galaxies with pure MgIII emission profiles have lower SFR surface densities than those with either MgIII P Cygni profiles or Fe II* emission. These spectral signatures produced through continuum scattering and fluorescence, MgIII P Cygni profiles and Fe II* emission, are better candidates for tracing galactic outflows than pure MgIII emission, which may originate from HIII regions. We compare the absorption and emission rest-frame equivalent widths for pairs of FeIII transitions to predictions from outflow models and find that the observations consistently have less total re-emission than absorption, suggesting either dust extinction or non-isotropic outflow geometries.

A high affinity monoclonal antibody recognizing the light chain of human coagulating factor VII.

PubMed

Sarial, Sheila; Asadi, Farzad; Jeddi-Tehrani, Mahmood; Hadavi, Reza; Bayat, Ali Ahmad; Mahmoudian, Jafar; Taghizadeh-Jahed, Masoud; Shokri, Fazel; Rabbani, Hodjattallah

2012-12-01

Factor VII (FVII) is a serine protease-coagulating element responsible for the initiation of an extrinsic pathway of clot formation. Here we generated and characterized a high affinity monoclonal antibody that specifically recognizes human FVII. Recombinant human FVII (rh-FVII) was used for the production of a monoclonal antibody using BALB/c mice. The specificity of the antibody was determined by Western blot using plasma samples from human, mouse, sheep, goat, bovine, rabbit, and rat. Furthermore, the antibody was used to detect transiently expressed rh-FVII in BHK21 cell line using Western blot and sandwich ELISA. A mouse IgG1 (kappa chain) monoclonal antibody clone 1F1-B11 was produced against rh-FVII. The affinity constant (K(aff)) of the antibody was calculated to be 6.4×10(10) M(-1). The antibody could specifically recognize an epitope on the light chain of hFVII, with no reactivity with factor VII from several other animals. In addition, transiently expressed rh-FVII in BHK21 cells was recognized by 1F1-B11. The high affinity as well as the specificity of 1F1-B11 for hFVII will facilitate the affinity purification of hFVII and also production of FVII deficient plasma and minimizes the risk of bovine FVII contamination when fetal bovine serum-supplemented media are used for production and subsequent purification of rh-FVII.

VizieR Online Data Catalog: 6.7GHz methanol maser polarization in SFR (Surcis+, 2015)

NASA Astrophysics Data System (ADS)

Surcis, G.; Vlemmings, W. H. T.; van Langevelde, H. J.; Hutawarakorn Kramer, B.; Bartkiewicz, A.; Blasi, M. G.

2015-09-01

The first seven massive SFRs were observed at 6.7GHz in full polarization spectral mode with eight of the EVN antennas (Effelsberg, Jodrell, Onsala, Medicina, Noto, Torun, Westerbork, and Yebes-40m) between November 2012 and June 2013, for a total observation time of 49h. The bandwidth was 2MHz, providing a velocity range of ~100km/s. (8 data files).

Fertility patterns according to occupational grouping in Norway, 1989.

PubMed

Strand, K; Wergeland, E; Bjerkedal, T

1996-03-01

In the early 1990s, most pregnant women in Norway were in gainful employment. This led to increased interest in the possible consequences for reproductive health, and a growing concern for the need to accommodate the pregnancy. We have therefore investigated how accurately general fertility rates predict the number of pregnancies in the workforce. Fertility rates (FR) among employed women and standardized fertility ratios (SFR) in occupational groups were estimated on the basis of information from the Labour Market Statistics and the national survey "Pregnancy and Work", Norway, 1989. The fertility rate among employed women was 17% higher than the general fertility rate. Two occupational groups had significantly different SFRs: technical/professional workers (SFR 118) and transport/communication workers (SFR 82). In addition, differences were found for parity-specific SFRs in administrative/executive work (SFR nullipara 80, SFR para 125) and service work (SFR nullipara 114, SFR para 80). We suggest that work status and occupation should be included among the variables registered in the Medical Birth Registry of Norway, in order to facilitate routine presentations of fertility rates and pregnancy outcomes for women in paid work. The results further indicate that work-specific conditions influence first-birth fertility. This should be explored in demographic studies of the relation between women's fertility and participation in paid work.

Kiloparsec-scale Simulations of Star Formation in Disk Galaxies. IV. Regulation of Galactic Star Formation Rates by Stellar Feedback

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butler, Michael J.; Tan, Jonathan C.; Teyssier, Romain

2017-06-01

Star formation from the interstellar medium of galactic disks is a basic process controlling the evolution of galaxies. Understanding the star formation rate (SFR) in a local patch of a disk with a given gas mass is thus an important challenge for theoretical models. Here we simulate a kiloparsec region of a disk, following the evolution of self-gravitating molecular clouds down to subparsec scales, as they form stars that then inject feedback energy by dissociating and ionizing UV photons and supernova explosions. We assess the relative importance of each feedback mechanism. We find that H{sub 2}-dissociating feedback results in themore » largest absolute reduction in star formation compared to the run with no feedback. Subsequently adding photoionization feedback produces a more modest reduction. Our fiducial models that combine all three feedback mechanisms yield, without fine-tuning, SFRs that are in excellent agreement with observations, with H{sub 2}-dissociating photons playing a crucial role. Models that only include supernova feedback—a common method in galaxy evolution simulations—settle to similar SFRs, but with very different temperatures and chemical states of the gas, and with very different spatial distributions of young stars.« less

Dual Active Galactic Nuclei in Nearby Galaxies

NASA Astrophysics Data System (ADS)

Das, Mousumi; Rubinur, Khatun; Karb, Preeti; Varghese, Ashlin; Novakkuni, Navyasree; James, Atul

2018-04-01

Galaxy mergers play a crucial role in the formation of massive galaxies and the buildup of their bulges. An important aspect of the merging process is the in-spiral of the supermassive black-holes (SMBHs) to the centre of the merger remnant and the eventual formation of a SMBH binary. If both the SMBHs are accreting they will form a dual or binary active galactic nucleus (DAGN). The final merger remnant is usually very bright and shows enhanced star formation. In this paper we summarise the current sample of DAGN from previous studies and describe methods that can be used to identify strong DAGN candidates from optical and spectroscopic surveys. These methods depend on the Doppler separation of the double peaked AGN emission lines, the nuclear velocity dispersion of the galaxies and their optical/UV colours. We describe two high resolution, radio observations of DAGN candidates that have been selected based on their double peaked optical emission lines (DPAGN). We also examine whether DAGN host galaxies have higher star formation rates (SFRs) compared to merging galaxies that do not appear to have DAGN. We find that the SFR is not higher for DAGN host galaxies. This suggests that the SFRs in DAGN host galaxies is due to the merging process itself and not related to the presence of two AGN in the system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shao, X.; Liang, Y. C.; Chen, X. Y.

We compare the host galaxies of 902 supernovae (SNe), including SNe Ia, SNe II, and SNe Ibc, which are selected by cross-matching the Asiago Supernova Catalog with the Sloan Digital Sky Survey (SDSS) Data Release 7. We selected an additional 213 galaxies by requiring the light fraction of spectral observations to be >15%, which could represent well the global properties of the galaxies. Among these 213 galaxies, 135 appear on the Baldwin-Phillips-Terlevich diagram, which allows us to compare the hosts in terms of whether they are star-forming (SF) galaxies, active galactic nuclei (AGNs; including composites, LINERs, and Seyfert 2s) ormore » absorption-line galaxies (Absorps; i.e., their related emission lines are weak or non-existent). The diagrams related to the parameters D{sub n}(4000), Hδ{sub A}, stellar masses, star formation rates (SFRs), and specific SFRs for the SNe hosts show that almost all SNe II and most of the SNe Ibc occur in SF galaxies, which have a wide range of stellar masses and low D{sub n}(4000). The SNe Ia hosts as SF galaxies following similar trends. A significant fraction of SNe Ia occurs in AGNs and absorption-line galaxies, which are massive and have high D{sub n}(4000). The stellar population analysis from spectral synthesis fitting shows that the hosts of SNe II have a younger stellar population than hosts of SNe Ia. These results are compared with those of the 689 comparison galaxies where the SDSS fiber captures less than 15% of the total light. These comparison galaxies appear biased toward higher 12+log(O/H) (∼0.1 dex) at a given stellar mass. Therefore, we believe the aperture effect should be kept in mind when the properties of the hosts for different types of SNe are discussed.« less

GAMA/H-ATLAS: a meta-analysis of SFR indicators - comprehensive measures of the SFR-M* relation and cosmic star formation history at z < 0.4

NASA Astrophysics Data System (ADS)

Davies, L. J. M.; Driver, S. P.; Robotham, A. S. G.; Grootes, M. W.; Popescu, C. C.; Tuffs, R. J.; Hopkins, A.; Alpaslan, M.; Andrews, S. K.; Bland-Hawthorn, J.; Bremer, M. N.; Brough, S.; Brown, M. J. I.; Cluver, M. E.; Croom, S.; da Cunha, E.; Dunne, L.; Lara-López, M. A.; Liske, J.; Loveday, J.; Moffett, A. J.; Owers, M.; Phillipps, S.; Sansom, A. E.; Taylor, E. N.; Michalowski, M. J.; Ibar, E.; Smith, M.; Bourne, N.

2016-09-01

We present a meta-analysis of star formation rate (SFR) indicators in the Galaxy And Mass Assembly (GAMA) survey, producing 12 different SFR metrics and determining the SFR-M* relation for each. We compare and contrast published methods to extract the SFR from each indicator, using a well-defined local sample of morphologically selected spiral galaxies, which excludes sources which potentially have large recent changes to their SFR. The different methods are found to yield SFR-M* relations with inconsistent slopes and normalizations, suggesting differences between calibration methods. The recovered SFR-M* relations also have a large range in scatter which, as SFRs of the targets may be considered constant over the different time-scales, suggests differences in the accuracy by which methods correct for attenuation in individual targets. We then recalibrate all SFR indicators to provide new, robust and consistent luminosity-to-SFR calibrations, finding that the most consistent slopes and normalizations of the SFR-M* relations are obtained when recalibrated using the radiation transfer method of Popescu et al. These new calibrations can be used to directly compare SFRs across different observations, epochs and galaxy populations. We then apply our calibrations to the GAMA II equatorial data set and explore the evolution of star formation in the local Universe. We determine the evolution of the normalization to the SFR-M* relation from 0 < z < 0.35 - finding consistent trends with previous estimates at 0.3 < z < 1.2. We then provide the definitive z < 0.35 cosmic star formation history, SFR-M* relation and its evolution over the last 3 billion years.

Towards a more realistic population of bright spiral galaxies in cosmological simulations

NASA Astrophysics Data System (ADS)

Aumer, Michael; White, Simon D. M.; Naab, Thorsten; Scannapieco, Cecilia

2013-10-01

We present an update to the multiphase smoothed particle hydrodynamics galaxy formation code by Scannapieco et al. We include a more elaborate treatment of the production of metals, cooling rates based on individual element abundances and a scheme for the turbulent diffusion of metals. Our supernova feedback model now transfers energy to the interstellar medium (ISM) in kinetic and thermal form, and we include a prescription for the effects of radiation pressure from massive young stars on the ISM. We calibrate our new code on the well-studied Aquarius haloes and then use it to simulate a sample of 16 galaxies with halo masses between 1 × 1011 and 3 × 1012 M⊙. In general, the stellar masses of the sample agree well with the stellar mass to halo mass relation inferred from abundance matching techniques for redshifts z = 0-4. There is however a tendency to overproduce stars at z > 4 and to underproduce them at z < 0.5 in the least massive haloes. Overly high star formation rates (SFRs) at z < 1 for the most massive haloes are likely connected to the lack of active galactic nuclei feedback in our model. The simulated sample also shows reasonable agreement with observed SFRs, sizes, gas fractions and gas-phase metallicities at z = 0-3. Remaining discrepancies can be connected to deviations from predictions for star formation histories from abundance matching. At z = 0, the model galaxies show realistic morphologies, stellar surface density profiles, circular velocity curves and stellar metallicities, but overly flat metallicity gradients. 15 out of 16 of our galaxies contain disc components with kinematic disc fraction ranging between 15 and 65 per cent. The disc fraction depends on the time of the last destructive merger or misaligned infall event. Considering the remaining shortcomings of our simulations we conclude that even higher kinematic disc fractions may be possible for Λ cold dark matter haloes with quiet merger histories, such as the Aquarius haloes.

Orthotopic AY-27 rat bladder urothelial cell carcinoma model presented an elevated methemoglobin proportion in the increased total hemoglobin content when evaluated in vivo by single-fiber reflectance spectroscopy

NASA Astrophysics Data System (ADS)

Sun, Tengfei; Davis, Carole A.; Hurst, Robert E.; Slaton, Joel W.; Piao, Daqing

2017-02-01

In vivo single-fiber reflectance spectroscopy (SfRS) was performed on an orthotopic AY-27 rat bladder urothelial cell carcinoma model to explore potential spectroscopic features revealing neoplastic changes. AY-27 bladder tumor cells were intravesically instilled in four rats and allowed to implant and grow for one week, with two additional rats as the control. A total of 107 SfRS measurements were taken from 27 sites on two control bladders and 80 from four AY-27 treated bladders. The spectral profiles obtained from AY-27 treated bladders revealed various levels of a methemoglobin (MetHb) characteristic spectral feature around 635nm. A multisegment spectral analysis method estimated concentrations of five chromophore compositions including oxyhemoglobin, deoxyhemoglobin, MetHb, lipid and water. The total hemoglobin concentration ([HbT]), the MetHb proportion in the total hemoglobin and the lipid volume content showed possible correlations. The 80 measurements from the AY-27 treated bladders could separate to three sub-sets according to the MetHb proportion. Specifically, 72 were in subset 1 with low proportion (5.3%<[MetHb]<7%), 6 in subset 2 with moderate proportion (7%<[MetHb]<30%), and 2 in subset 3 with significant proportion (>30%). When grouped according to [MetHB], the [HbT] increased from 368 μM of subset 1 to 488 μM of subset 2 to 541 μM of subset 3, in comparison to the 285 μM of the control. The increased total hemoglobin and the elevation of MetHb proportion may signify angiogenesis and degradation in hemoglobin oxygen-transport. Additionally, the lipid volume content decreased from 2.58% in the control to <0.2% in the tumor groups, indicating disruption of subepithelium tissue architecture.

Galaxy And Mass Assembly: resolving the role of environment in galaxy evolution

NASA Astrophysics Data System (ADS)

Brough, S.; Croom, S.; Sharp, R.; Hopkins, A. M.; Taylor, E. N.; Baldry, I. K.; Gunawardhana, M. L. P.; Liske, J.; Norberg, P.; Robotham, A. S. G.; Bauer, A. E.; Bland-Hawthorn, J.; Colless, M.; Foster, C.; Kelvin, L. S.; Lara-Lopez, M. A.; López-Sánchez, Á. R.; Loveday, J.; Owers, M.; Pimbblet, K. A.; Prescott, M.

2013-11-01

We present observations of 18 galaxies from the Galaxy And Mass Assembly (GAMA) survey made with the SPIRAL optical integral field unit (IFU) on the Anglo-Australian Telescope. The galaxies are selected to have a narrow range in stellar mass (6 × 109 < M* < 2 × 1010 M⊙) in order to focus on the effects of environment. Local galaxy environments are measured quantitatively using fifth nearest neighbour surface densities. We find that the total star formation rates (SFR) measured from the IFU data are consistent with total SFRs measured from aperture correcting either GAMA or Sloan Digital Sky Survey single-fibre observations. The mean differences are SFRGAMA/SFRIFU = 1.26 ± 0.23, σ = 0.90 and for the Sloan Digital Sky Survey we similarly find SFRBrinchmann/SFRIFU = 1.34 ± 0.17, σ = 0.67. Examining the relationships with environment, we find that off-centre and clumpy Hα emission is not significantly dependent on environment, being present in 2/7 (29^{+20}_{-11} per cent) galaxies in high-density environments (>0.77 Mpc-2), and 5/11 (45^{+15}_{-13} per cent) galaxies in low-density environments (<0.77 Mpc-2). We find a weak but not significant relationship of the total SFRs of star-forming galaxies with environment. Due to the size of our sample and the scatter observed we do not draw a definitive conclusion about a possible SFR dependence on environment. Examining the spatial distribution of the Hα emission, we find no evidence for a change in shape or amplitude of the radial profile of star-forming galaxies with environment. If these observations are borne out in larger samples, this would infer that any environment-driven star formation suppression must either act very rapidly (the `infall-and-quench' model) or that galaxies must evolve in a density-dependent manner (an `in situ evolution' model).

PHIBSS: Unified Scaling Relations of Gas Depletion Time and Molecular Gas Fractions

NASA Astrophysics Data System (ADS)

Tacconi, L. J.; Genzel, R.; Saintonge, A.; Combes, F.; García-Burillo, S.; Neri, R.; Bolatto, A.; Contini, T.; Förster Schreiber, N. M.; Lilly, S.; Lutz, D.; Wuyts, S.; Accurso, G.; Boissier, J.; Boone, F.; Bouché, N.; Bournaud, F.; Burkert, A.; Carollo, M.; Cooper, M.; Cox, P.; Feruglio, C.; Freundlich, J.; Herrera-Camus, R.; Juneau, S.; Lippa, M.; Naab, T.; Renzini, A.; Salome, P.; Sternberg, A.; Tadaki, K.; Übler, H.; Walter, F.; Weiner, B.; Weiss, A.

2018-02-01

This paper provides an update of our previous scaling relations between galaxy-integrated molecular gas masses, stellar masses, and star formation rates (SFRs), in the framework of the star formation main sequence (MS), with the main goal of testing for possible systematic effects. For this purpose our new study combines three independent methods of determining molecular gas masses from CO line fluxes, far-infrared dust spectral energy distributions, and ∼1 mm dust photometry, in a large sample of 1444 star-forming galaxies between z = 0 and 4. The sample covers the stellar mass range log(M */M ⊙) = 9.0–11.8, and SFRs relative to that on the MS, δMS = SFR/SFR(MS), from 10‑1.3 to 102.2. Our most important finding is that all data sets, despite the different techniques and analysis methods used, follow the same scaling trends, once method-to-method zero-point offsets are minimized and uncertainties are properly taken into account. The molecular gas depletion time t depl, defined as the ratio of molecular gas mass to SFR, scales as (1 + z)‑0.6 × (δMS)‑0.44 and is only weakly dependent on stellar mass. The ratio of molecular to stellar mass μ gas depends on (1+z{)}2.5× {(δ {MS})}0.52× {({M}* )}-0.36, which tracks the evolution of the specific SFR. The redshift dependence of μ gas requires a curvature term, as may the mass dependences of t depl and μ gas. We find no or only weak correlations of t depl and μ gas with optical size R or surface density once one removes the above scalings, but we caution that optical sizes may not be appropriate for the high gas and dust columns at high z. Based on observations of an IRAM Legacy Program carried out with the NOEMA, operated by the Institute for Radio Astronomy in the Millimetre Range (IRAM), which is funded by a partnership of INSU/CNRS (France), MPG (Germany), and IGN (Spain).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Straatman, Caroline M. S.; Labbé, Ivo; Van Houdt, Josha

The FourStar galaxy evolution survey (ZFOURGE) is a 45 night legacy program with the FourStar near-infrared camera on Magellan and one of the most sensitive surveys to date. ZFOURGE covers a total of 400 arcmin{sup 2} in cosmic fields CDFS, COSMOS and UDS, overlapping CANDELS. We present photometric catalogs comprising >70,000 galaxies, selected from ultradeep K {sub s} -band detection images (25.5–26.5 AB mag, 5 σ , total), and >80% complete to K {sub s} < 25.3–25.9 AB. We use 5 near-IR medium-bandwidth filters ( J {sub 1}, J {sub 2}, J {sub 3}, H {sub s} , H {submore » l} ) as well as broad-band K {sub s} at 1.05–2.16 μ m to 25–26 AB at a seeing of ∼0.″5. Each field has ancillary imaging in 26–40 filters at 0.3–8 μ m. We derive photometric redshifts and stellar population properties. Comparing with spectroscopic redshifts indicates a photometric redshift uncertainty σ {sub z} = 0.010, 0.009, and 0.011 in CDFS, COSMOS, and UDS. As spectroscopic samples are often biased toward bright and blue sources, we also inspect the photometric redshift differences between close pairs of galaxies, finding σ {sub z} {sub ,pairs} = 0.01–0.02 at 1 < z < 2.5. We quantify how σ {sub z} {sub ,pairs} depends on redshift, magnitude, spectral energy distribution type, and the inclusion of FourStar medium bands. σ {sub z} {sub ,pairs} is smallest for bright, blue star-forming samples, while red star-forming galaxies have the worst σ {sub z} {sub ,pairs}. Including FourStar medium bands reduces σ {sub z} {sub ,pairs} by 50% at 1.5 < z < 2.5. We calculate star formation rates (SFRs) based on ultraviolet and ultradeep far-IR Spitzer /MIPS and Herschel /PACS data. We derive rest-frame U − V and V − J colors, and illustrate how these correlate with specific SFR and dust emission to z = 3.5. We confirm the existence of quiescent galaxies at z ∼ 3, demonstrating their SFRs are suppressed by > ×15.« less

ALMA imaging of gas and dust in a galaxy protocluster at redshift 5.3: [C II] emission in 'typical' galaxies and dusty starbursts ≈1 billion years after the big bang

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riechers, Dominik A.; Carilli, Christopher L.; Capak, Peter L.

2014-12-01

We report interferometric imaging of [C II]({sup 2} P {sub 3/2}→{sup 2} P {sub 1/2}) and OH({sup 2}Π{sub 1/2} J = 3/2→1/2) emission toward the center of the galaxy protocluster associated with the z = 5.3 submillimeter galaxy (SMG) AzTEC-3, using the Atacama Large (sub)Millimeter Array (ALMA). We detect strong [C II], OH, and rest-frame 157.7 μm continuum emission toward the SMG. The [C II]({sup 2} P {sub 3/2}→{sup 2} P {sub 1/2}) emission is distributed over a scale of 3.9 kpc, implying a dynamical mass of 9.7 × 10{sup 10} M {sub ☉}, and a star formation rate (SFR)more » surface density of Σ{sub SFR} = 530 M {sub ☉} yr{sup –1} kpc{sup –2}. This suggests that AzTEC-3 forms stars at Σ{sub SFR} approaching the Eddington limit for radiation pressure supported disks. We find that the OH emission is slightly blueshifted relative to the [C II] line, which may indicate a molecular outflow associated with the peak phase of the starburst. We also detect and dynamically resolve [C II]({sup 2} P {sub 3/2}→{sup 2} P {sub 1/2}) emission over a scale of 7.5 kpc toward a triplet of Lyman-break galaxies with moderate UV-based SFRs in the protocluster at ∼95 kpc projected distance from the SMG. These galaxies are not detected in the continuum, suggesting far-infrared SFRs of <18-54 M {sub ☉} yr{sup –1}, consistent with a UV-based estimate of 22 M {sub ☉} yr{sup –1}. The spectral energy distribution of these galaxies is inconsistent with nearby spiral and starburst galaxies, but resembles those of dwarf galaxies. This is consistent with expectations for young starbursts without significant older stellar populations. This suggests that these galaxies are significantly metal-enriched, but not heavily dust-obscured, 'normal' star-forming galaxies at z > 5, showing that ALMA can detect the interstellar medium in 'typical' galaxies in the very early universe.« less

Prognostic Impact of Stone-Scoring Systems After Percutaneous Nephrolithotomy for Staghorn Calculi: A Single Center's Experience Over 10 Years.

PubMed

Choi, Sae Woong; Bae, Woong Jin; Ha, U-Syn; Hong, Sung-Hoo; Lee, Ji Youl; Kim, Sae Woong; Cho, Hyuk Jin

2016-09-01

To investigate the prognostic factors associated with stone-free rate (SFR) and complications after percutaneous nephrolithotomy (PCNL) for the treatment of staghorn stone and to compare the predictive value and accuracy of three stone-scoring systems for the treatment success of staghorn stone. We retrospectively reviewed all patients undergoing PCNL at our center from June 2003 to June 2014. On the basis of noncontrast computed tomography (NCCT) scan images, we calculated Guy's score, S.T.O.N.E. nephrolithometry, and Clinical Research Office of the Endourological Society (CROES) nomogram to assess the association with stone-free status and complications. For statistical evaluation, univariate and multivariate logistic regression analyses were used. During the study period, 886 cases had medical records available. Cases who underwent PCNL for the treatment of staghorn calculi accounted for 34.4% (305/886 cases). Preoperative NCCT was performed in 217 cases. The 217 procedures (205 patients, 12 simultaneous bilateral PCNLs) had a mean stone size of 1358.3 ± 760.7 mm(2), with 111 (51.2%) partial staghorn and 106 (48.8%) complete staghorn stones. The initial and overall SFRs of PCNL were 53.9% and 70.1%, respectively. The overall complication rate was 32.7% (71/217 cases). On a multivariate logistic regression analysis, independent predictors for SFR were number of involved calices, S.T.O.N.E. nephrolithometry, and pre-existent urinary tract infection (UTI) (odds ratios [ORs] = 1.311, 1.933, and 2.340, respectively). Stone burden was an independent risk factor for the development of complications on multivariate analysis (OR = 2.846 and p = 0.001). The results of this study show that multiple involved calices, high grades of S.T.O.N.E. nephrolithometry, and pre-existent UTIs were associated with lower SFR after PCNL for staghorn calculi. Stone burden was an independent risk factor for the development of complications.

The Universe's Most Extreme Star-forming Galaxies

NASA Astrophysics Data System (ADS)

Casey, Caitlin

2017-06-01

Dusty star-forming galaxies host the most intense stellar nurseries in the Universe. Their unusual characteristics (SFRs=200-2000Msun/yr, Mstar>1010 Msun) pose a unique challenge for cosmological simulations and galaxy formation theory, particularly at early times. Although rare today, they were factors of 1000 times more prevalent at z~2-5, contributing significantly to the buildup of the Universe's stellar mass and the formation of high-mass galaxies. At even earlier times (within 1Gyr post Big Bang) they could have played a pivotal role in enriching the IGM. However, an ongoing debate lingers as to their evolutionary origins at high-redshift, whether or not they are triggered by major mergers of gas-rich disk galaxies, or if they are solitary galaxies continually fed pristine gas from the intergalactic medium. Furthermore, their presence in early protoclusters, only revealed quite recently, pose intriguing questions regarding the collapse of large scale structure. I will discuss some of the latest observational programs dedicated to understanding dust-obscuration in and gas content of the early Universe, their context in the cosmic web, and future long-term observing campaigns that may reveal their relationship to `normal’ galaxies, thus teaching us valuable lessons on the physical mechanisms of galaxy growth and the collapse of large scale structure in an evolving Universe.

Building on knowledge base of sodium cooled fast spectrum reactors to develop materials technology for fusion reactors

NASA Astrophysics Data System (ADS)

Raj, Baldev; Rao, K. Bhanu Sankara

2009-04-01

The alloys 316L(N) and Mod. 9Cr-1Mo steel are the major structural materials for fabrication of structural components in sodium cooled fast reactors (SFRs). Various factors influencing the mechanical behaviour of these alloys and different modes of deformation and failure in SFR systems, their analysis and the simulated tests performed on components for assessment of structural integrity and the applicability of RCC-MR code for the design and validation of components are highlighted. The procedures followed for optimal design of die and punch for the near net shape forming of petals of main vessel of 500 MWe prototype fast breeder reactor (PFBR); the safe temperature and strain rate domains established using dynamic materials model for forming of 316L(N) and 9Cr-1Mo steels components by various industrial processes are illustrated. Weldability problems associated with 316L(N) and Mo. 9Cr-1Mo are briefly discussed. The utilization of artificial neural network models for prediction of creep rupture life and delta-ferrite in austenitic stainless steel welds is described. The usage of non-destructive examination techniques in characterization of deformation, fracture and various microstructural features in SFR materials is briefly discussed. Most of the experience gained on SFR systems could be utilized in developing science and technology for fusion reactors. Summary of the current status of knowledge on various aspects of fission and fusion systems with emphasis on cross fertilization of research is presented.

Environmental Effects on Evolution of Cluster Galaxies in a Λ-dominated Cold Dark Matter Universe

NASA Astrophysics Data System (ADS)

Okamoto, Takashi; Nagashima, Masahiro

2003-04-01

We investigate environmental effects on evolution of bright cluster galaxies (L>L*) in a Λ-dominated cold dark matter universe using a combination of dissipationless N-body simulations and a semianalytic galaxy formation model. The N-body simulations enable us to calculate orbits of galaxies in simulated clusters. Therefore, we can incorporate stripping of cold gas from galactic disks by ram pressure (RP) from the intracluster medium into our model. In this paper we study how ram pressure stripping (RPS) and small starburst induced by a minor merger affect colors, star formation rates (SFRs), and morphologies of cluster galaxies. These processes are new ingredients in our model and have not been studied sufficiently. We find that the RPS is not important for colors and SFRs of galaxies in the cluster core if the star formation timescale is properly chosen, because the star formation is sufficiently suppressed by consumption of the cold gas in the disks. Then observed color and SFR gradients can be reproduced without the RPS. The small starburst triggered by a minor merger hardly affects the SFRs and colors of the galaxies as well. We also examine whether these two processes can resolve the known problem that the hierarchical clustering models based on the major merger-driven bulge formation scenario predict too few galaxies of intermediate bulge-to-total luminosity ratio (B/T) in clusters. When the minor burst is taken into account, the intermediate B/T population is increased, and the observed morphology gradients in clusters are successfully reproduced. Without the minor burst, the RPS cannot increase the intermediate B/T population. On the other hand, when the minor burst is considered, the RPS also plays an important role in formation of the intermediate B/T galaxies. We present redshift evolution of morphological fractions predicted by our models. The predicted number ratios of the intermediate B/T galaxies to the bulge-dominated galaxies show nearly flat or slightly increasing trends with increasing redshift. We conclude that these trends are inevitable when bulges are formed through mergers. We discuss whether our results conflict with observationally suggested NS0/NE evolution in clusters, which is a decreasing function of redshift.

The Initial Conditions and Evolution of Isolated Galaxy Models: Effects of the Hot Gas Halo

NASA Astrophysics Data System (ADS)

Hwang, Jeong-Sun; Park, Changbom; Choi, Jun-Hwan

2013-02-01

We construct several Milky Way-like galaxy models containing a gas halo (as well as gaseous and stellar disks, a dark matter halo, and a stellar bulge) following either an isothermal or an NFW density profile with varying mass and initial spin. In addition, galactic winds associated with star formation are tested in some of the simulations. We evolve these isolated galaxy models using the GADGET-3 N-body/hydrodynamic simulation code, paying particular attention to the effects of the gaseous halo on the evolution. We find that the evolution of the models is strongly affected by the adopted gas halo component, particularly in the gas dissipation and the star formation activity in the disk. The model without a gas halo shows an increasing star formation rate (SFR) at the beginning of the simulation for some hundreds of millions of years and then a continuously decreasing rate to the end of the run at 3 Gyr. Whereas the SFRs in the models with a gas halo, depending on the density profile and the total mass of the gas halo, emerge to be either relatively flat throughout the simulations or increasing until the middle of the run (over a gigayear) and then decreasing to the end. The models with the more centrally concentrated NFW gas halo show overall higher SFRs than those with the isothermal gas halo of the equal mass. The gas accretion from the halo onto the disk also occurs more in the models with the NFW gas halo, however, this is shown to take place mostly in the inner part of the disk and not to contribute significantly to the star formation unless the gas halo has very high density at the central part. The rotation of a gas halo is found to make SFR lower in the model. The SFRs in the runs including galactic winds are found to be lower than those in the same runs but without winds. We conclude that the effects of a hot gaseous halo on the evolution of galaxies are generally too significant to be simply ignored. We also expect that more hydrodynamical processes in galaxies could be understood through numerical simulations employing both gas disk and gas halo components.

Observations of starburst galaxies: Science and supporting technology

NASA Astrophysics Data System (ADS)

Laag, Edward Aric

In chapter 1 we report on the development of wavefront reconstruction and control algorithms for multi-conjugate adaptive optics (MCAO) and the results of testing them in the laboratory under conditions that simulate an 8 meter class telescope. The UCO/Lick Observatory Laboratory for Adaptive Optics Multi-Conjugate testbed allows us to test wide field of view adaptive optics systems as they might be instantiated in the near future on giant telescopes. In particular, we have been investigating the performance of MCAO using five laser beacons for wavefront sensing and a minimum variance algorithm for control of two conjugate deformable mirrors. We have demonstrated improved Strehl ratio and enlarged field of view performance when compared to conventional AO techniques. We have demonstrated improved MCAO performance with the implementation of a routine that minimizes the generalized isoplanatism when turbulent layers do not correspond to deformable mirror conjugate altitudes. Finally, we have demonstrated suitability of the system for closed-loop operation when configured to feed back conditional mean estimates of wavefront residuals rather than the directly measured residuals. This technique has recently been referred to as the "pseudo-open-loop" control law in the literature. Chapter 2 introduces the Multi-wavelength Extreme Starburst Sample (MESS), a new catalog of 138 star-forming galaxies (0.1 < z < 0.3) optically selected from the SDSS using emission line strength diagnostics to have SFR ≥ 50 M⊙ yr-1 based on a Kroupa IMF. The MESS was designed to complement samples of nearby star forming galaxies such as the luminous infrared galaxies (LIRGs), and ultraviolet luminous galaxies (UVLGs). Observations using the multiband imaging photometer (MIPS; 24, 70, and 160mum channels) on the Spitzer Space Telescope indicate the MESS galaxies have IR luminosities similar to those of LIRGs, with an estimated median LTIR ˜ 3 x 1011 L⊙ . The selection criteria for the MESS suggests they may be less obscured than typical far-IR selected galaxies with similar estimated SFRs. We estimate the SFRs based directly on luminosities to determine the agreement for these methods in the MESS.

Mid-infrared luminous quasars in the GOODS-Herschel fields: a large population of heavily obscured, Compton-thick quasars at z ≈ 2

NASA Astrophysics Data System (ADS)

Del Moro, A.; Alexander, D. M.; Bauer, F. E.; Daddi, E.; Kocevski, D. D.; McIntosh, D. H.; Stanley, F.; Brandt, W. N.; Elbaz, D.; Harrison, C. M.; Luo, B.; Mullaney, J. R.; Xue, Y. Q.

2016-02-01

We present the infrared (IR) and X-ray properties of a sample of 33 mid-IR luminous quasars (νL6 μm ≥ 6 × 1044 erg s-1) at redshift z ≈ 1-3, identified through detailed spectral energy distribution analyses of distant star-forming galaxies, using the deepest IR data from Spitzer and Herschel in the GOODS-Herschel fields. The aim is to constrain the fraction of obscured, and Compton-thick (CT, NH > 1.5 × 1024 cm-2) quasars at the peak era of nuclear and star formation activities. Despite being very bright in the mid-IR band, ≈30 per cent of these quasars are not detected in the extremely deep 2 and 4 Ms Chandra X-ray data available in these fields. X-ray spectral analysis of the detected sources reveals that the majority (≈67 per cent) are obscured by column densities NH > 1022 cm-2; this fraction reaches ≈80 per cent when including the X-ray-undetected sources (9 out of 33), which are likely to be the most heavily obscured, CT quasars. We constrain the fraction of CT quasars in our sample to be ≈24-48 per cent, and their space density to be Φ = (6.7 ± 2.2) × 10-6 Mpc-3. From the investigation of the quasar host galaxies in terms of star formation rates (SFRs) and morphological distortions, as a sign of galaxy mergers/interactions, we do not find any direct relation between SFRs and quasar luminosity or X-ray obscuration. On the other hand, there is tentative evidence that the most heavily obscured quasars have, on average, more disturbed morphologies than the unobscured/moderately obscured quasar hosts, which preferentially live in undisturbed systems. However, the fraction of quasars with disturbed morphology amongst the whole sample is ≈40 per cent, suggesting that galaxy mergers are not the main fuelling mechanism of quasars at z ≈ 2.

THE STAR FORMATION RATE OF TURBULENT MAGNETIZED CLOUDS: COMPARING THEORY, SIMULATIONS, AND OBSERVATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Federrath, Christoph; Klessen, Ralf S., E-mail: christoph.federrath@monash.edu

2012-12-20

The role of turbulence and magnetic fields is studied for star formation in molecular clouds. We derive and compare six theoretical models for the star formation rate (SFR)-the Krumholz and McKee (KM), Padoan and Nordlund (PN), and Hennebelle and Chabrier (HC) models, and three multi-freefall versions of these, suggested by HC-all based on integrals over the log-normal distribution of turbulent gas. We extend all theories to include magnetic fields and show that the SFR depends on four basic parameters: (1) virial parameter {alpha}{sub vir}; (2) sonic Mach number M; (3) turbulent forcing parameter b, which is a measure for themore » fraction of energy driven in compressive modes; and (4) plasma {beta}=2M{sub A}{sup 2}/M{sup 2} with the Alfven Mach number M{sub A}. We compare all six theories with MHD simulations, covering cloud masses of 300 to 4 Multiplication-Sign 10{sup 6} M{sub Sun} and Mach numbers M=3-50 and M{sub A}=1-{infinity}, with solenoidal (b = 1/3), mixed (b = 0.4), and compressive turbulent (b = 1) forcings. We find that the SFR increases by a factor of four between M=5 and 50 for compressive turbulent forcing and {alpha}{sub vir} {approx} 1. Comparing forcing parameters, we see that the SFR is more than 10 times higher with compressive than solenoidal forcing for M=10 simulations. The SFR and fragmentation are both reduced by a factor of two in strongly magnetized, trans-Alfvenic turbulence compared to hydrodynamic turbulence. All simulations are fit simultaneously by the multi-freefall KM and multi-freefall PN theories within a factor of two over two orders of magnitude in SFR. The simulated SFRs cover the range and correlation of SFR column density with gas column density observed in Galactic clouds, and agree well for star formation efficiencies SFE = 1%-10% and local efficiencies {epsilon} = 0.3-0.7 due to feedback. We conclude that the SFR is primarily controlled by interstellar turbulence, with a secondary effect coming from magnetic fields.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Meimei; Natesan, K.; Chen, Wei-Ying

This report provides an update on the understanding of the effect of sodium exposures on microstructure and tensile properties of Grade 91 (G91) steel in support of the design and operation of G91 components in sodium-cooled fast reactors (SFRs). The report is a Level 3 deliverable in FY17 (M3AT-17AN1602018), under the Work Package AT-17AN160201, “SFR Materials Testing” performed by the Argonne National Laboratory (ANL), as part of the Advanced Reactor Technologies Program.

SCUSS u- BAND EMISSION AS A STAR-FORMATION-RATE INDICATOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Zhimin; Zhou, Xu; Wu, Hong

2017-01-20

We present and analyze the possibility of using optical u- band luminosities to estimate star-formation rates (SFRs) of galaxies based on the data from the South Galactic Cap u band Sky Survey (SCUSS), which provides a deep u -band photometric survey covering about 5000 deg{sup 2} of the South Galactic Cap. Based on two samples of normal star-forming galaxies selected by the BPT diagram, we explore the correlations between u -band, H α , and IR luminosities by combing SCUSS data with the Sloan Digital Sky Survey and Wide-field Infrared Survey Explorer ( WISE ). The attenuation-corrected u -band luminositiesmore » are tightly correlated with the Balmer decrement-corrected H α luminosities with an rms scatter of ∼0.17 dex. The IR-corrected u luminosities are derived based on the correlations between the attenuation of u- band luminosities and WISE 12 (or 22) μ m luminosities, and then calibrated with the Balmer-corrected H α luminosities. The systematic residuals of these calibrations are tested against the physical properties over the ranges covered by our sample objects. We find that the best-fitting nonlinear relations are better than the linear ones and recommended to be applied in the measurement of SFRs. The systematic deviations mainly come from the pollution of old stellar population and the effect of dust extinction; therefore, a more detailed analysis is needed in future work.« less

Scuss u-Band Emission as a Star-Formation-Rate Indicator

NASA Astrophysics Data System (ADS)

Zhou, Zhimin; Zhou, Xu; Wu, Hong; Fan, Xiao-Hui; Fan, Zhou; Jiang, Zhao-Ji; Jing, Yi-Peng; Li, Cheng; Lesser, Michael; Jiang, Lin-Hua; Ma, Jun; Nie, Jun-Dan; Shen, Shi-Yin; Wang, Jia-Li; Wu, Zhen-Yu; Zhang, Tian-Meng; Zou, Hu

2017-01-01

We present and analyze the possibility of using optical u-band luminosities to estimate star-formation rates (SFRs) of galaxies based on the data from the South Galactic Cap u band Sky Survey (SCUSS), which provides a deep u-band photometric survey covering about 5000 deg2 of the South Galactic Cap. Based on two samples of normal star-forming galaxies selected by the BPT diagram, we explore the correlations between u-band, Hα, and IR luminosities by combing SCUSS data with the Sloan Digital Sky Survey and Wide-field Infrared Survey Explorer (WISE). The attenuation-corrected u-band luminosities are tightly correlated with the Balmer decrement-corrected Hα luminosities with an rms scatter of ˜0.17 dex. The IR-corrected u luminosities are derived based on the correlations between the attenuation of u-band luminosities and WISE 12 (or 22) μm luminosities, and then calibrated with the Balmer-corrected Hα luminosities. The systematic residuals of these calibrations are tested against the physical properties over the ranges covered by our sample objects. We find that the best-fitting nonlinear relations are better than the linear ones and recommended to be applied in the measurement of SFRs. The systematic deviations mainly come from the pollution of old stellar population and the effect of dust extinction; therefore, a more detailed analysis is needed in future work.

The pathophysiology of glossal pain in patients with iron deficiency and anemia.

PubMed

Osaki, T; Ueta, E; Arisawa, K; Kitamura, Y; Matsugi, N

1999-11-01

It is well known that prolonged anemia causes atrophy of tongue papillae, glossal pain, and dysphagia, but it is uncertain whether iron (Fe) deficiency induces glossal pain without any objective manifestation. To resolve this matter, the relationship between Fe deficiency and glossal pain was examined. Eighteen patients with Fe deficiency and 7 anemic patients manifesting spontaneous irritation or pain of the tongue without any objective abnormalities participated in this study. To ascertain the cause of glossal pain and the oral pathophysiology in Fe deficiency and anemia, peripheral blood was examined and the glossal pain threshold and salivary flow rates (SFRs) were estimated along with Candida albicans cell culture tests. Compared with patients with Fe deficiency, those with anemia had a longer history of tongue pain. In patients with anemia, painful areas of the tongue were more numerous than in patients with Fe deficiency. Pain thresholds were decreased in the painful portions, and both nonstimulated and stimulated SFRs were suppressed. Each patient was treated with oral Fe; within 2 months, most patients exhibited increased serum ferritin level (P< 0.02, paired t-test), pain threshold (P < 0.05) and salivation (P < 0.05) and glossal pain subsided. Fe deficiency causes glossal pain and the degree of glossal pain increases as Fe deficiency advances to anemia, manifesting hyposalivation and abnormalities of glossal papillae.

Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buchman, A.R.; Kimmerly, W.J.; Rine, J.

1988-01-01

Two DNA-binding factors from Saccharomyces cerevisiae have been characterized, GRFI (general regulatory factor I) and ABFI (ARS-binding factor I), that recognize specific sequences within diverse genetic elements. GRFI bound to sequences at the negative regulatory elements (silencers) of the silent mating type loci HML E and HMR E and to the upstream activating sequence (UAS) required for transcription of the MAT ..cap alpha.. genes. A putative conserved UAS located at genes involved in translation (RPG box) was also recognized by GRFI. In addition, GRFI bound with high affinity to sequences within the (C/sub 1-3/A)-repeat region at yeast telomeres. Binding sitesmore » for GRFI with the highest affinity appeared to be of the form 5'-(A/G)(A/C)ACCCAN NCA(T/C)(T/C)-3', where N is any nucleotide. ABFI-binding sites were located next to autonomously replicating sequences (ARSs) at controlling elements of the silent mating type loci HMR E, HMR I, and HML I and were associated with ARS1, ARS2, and the 2..mu..m plasmid ARS. Two tandem ABFI binding sites were found between the HIS3 and DED1 genes, several kilobase pairs from any ARS, indicating that ABFI-binding sites are not restricted to ARSs. The sequences recognized by AFBI showed partial dyad-symmetry and appeared to be variations of the consensus 5'-TATCATTNNNNACGA-3'. GRFI and ABFI were both abundant DNA-binding factors and did not appear to be encoded by the SIR genes, whose product are required for repression of the silent mating type loci. Together, these results indicate that both GRFI and ABFI play multiple roles within the cell.« less

The collaborative effect of ram pressure and merging on star formation and stripping fraction

NASA Astrophysics Data System (ADS)

Bischko, J. C.; Steinhauser, D.; Schindler, S.

2015-04-01

Aims: We investigate the effect of ram pressure stripping (RPS) on several simulations of merging pairs of gas-rich spiral galaxies. We are concerned with the changes in stripping efficiency and the time evolution of the star formation rate. Our goal is to provide an estimate of the combined effect of merging and RPS compared to the influence of the individual processes. Methods: We make use of the combined N-body/hydrodynamic code GADGET-2. The code features a threshold-based statistical recipe for star formation, as well as radiative cooling and modeling of galactic winds. In our simulations, we vary mass ratios between 1:4 and 1:8 in a binary merger. We sample different geometric configurations of the merging systems (edge-on and face-on mergers, different impact parameters). Furthermore, we vary the properties of the intracluster medium (ICM) in rough steps: the speed of the merging system relative to the ICM between 500 and 1000 km s-1, the ICM density between 10-29 and 10-27 g cm-3, and the ICM direction relative to the mergers' orbital plane. Ram pressure is kept constant within a simulation time period, as is the ICM temperature of 107 K. Each simulation in the ICM is compared to simulations of the merger in vacuum and the non-merging galaxies with acting ram pressure. Results: Averaged over the simulation time (1 Gyr) the merging pairs show a negligible 5% enhancement in SFR, when compared to single galaxies under the same environmental conditions. The SFRs peak at the time of the galaxies first fly-through. There, our simulations show SFRs of up to 20 M⊙ yr-1 (compared to 3 M⊙ yr-1 of the non-merging galaxies in vacuum). In the most extreme case, this constitutes a short-term (<50 Myr) SFR increase of 50 % over the non-merging galaxies experiencing ram pressure. The wake of merging galaxies in the ICM typically has a third to half the star mass seen in the non-merging galaxies and 5% to 10% less gas mass. The joint effect of RPS and merging, according to our simulations, is not significantly different from pure ram pressure effects.

A Kennicutt-Schmidt relation at molecular cloud scales and beyond

NASA Astrophysics Data System (ADS)

Khoperskov, Sergey A.; Vasiliev, Evgenii O.

2017-06-01

Using N-body/gasdynamic simulations of a Milky Way-like galaxy, we analyse a Kennicutt-Schmidt (KS) relation, Σ _SFR ∝ Σ _gas^N, at different spatial scales. We simulate synthetic observations in CO lines and ultraviolet (UV) band. We adopt the star formation rate (SFR) defined in two ways: based on free fall collapse of a molecular cloud - ΣSFR, cl, and calculated by using a UV flux calibration - ΣSFR,UV. We study a KS relation for spatially smoothed maps with effective spatial resolution from molecular cloud scales to several hundred parsecs. We find that for spatially and kinematically resolved molecular clouds the Σ _{SFR, cl} ∝ σ _{gas}^N relation follows the power law with index N ≈ 1.4. Using UV flux as SFR calibrator, we confirm a systematic offset between the ΣSFR,UV and Σgas distributions on scales compared to molecular cloud sizes. Degrading resolution of our simulated maps for surface densities of gas and SFRs, we establish that there is no relation ΣSFR,UV -Σgas below the resolution ˜50 pc. We find a transition range around scales ˜50-120 pc, where the power-law index N increases from 0 to 1-1.8 and saturates for scales larger ˜120 pc. A value of the index saturated depends on a surface gas density threshold and it becomes steeper for higher Σgas threshold. Averaging over scales with size of ≳ 150 pc the power-law index N equals 1.3-1.4 for surface gas density threshold ˜5 M⊙ pc-2. At scales ≳ 120 pc surface SFR densities determined by using CO data and UV flux, ΣSFR,UV/SFR, cl, demonstrate a discrepancy about a factor of 3. We argue that this may be originated from overestimating (constant) values of conversion factor, star formation efficiency or UV calibration used in our analysis.

Dusty Star Forming Galaxies and Supermassive Black Holes at High Redshifts: In- Situ Coevolution

NASA Astrophysics Data System (ADS)

Mancuso, Claudia

2016-10-01

We have exploited the continuity equation approach and the star-formation timescales derived from the observed 'main sequence' relation (Star Formation Rate vs Stellar Mass), to show that the observed high abundance of galaxies with stellar masses ≥ a few 10^10 M⊙ at redshift z ≥ 4 implies the existence of a galaxy population featuring large star formation rates (SFRs) ψ ≥ 10^2 M⊙ yr^-1 in heavily dust-obscured conditions. These galaxies constitute the high-redshift counterparts of the dusty star-forming population already surveyed for z ≤ 3 in the Far-InfraRed (FIR) band by the Herschel space observatory. We work out specific predictions for the evolution of the corresponding stellar mass and SFR functions out to z ∼10, elucidating that the number density at z ≤ 8 for SFRs ψ ≥ 30 M⊙ yr^-1 cannot be estimated relying on the UltraViolet (UV) luminosity function alone, even when standard corrections for dust extinction based on the UV slope are applied. We compute the number counts and redshift distributions (including galaxy-scale gravitational lensing) of this galaxy population, and show that current data from AzTEC-LABOCA, SCUBA-2 and ALMA-SPT surveys are already digging into it. We substantiate how an observational strategy based on a color preselection in the far-IR or (sub-)mm band with Herschel and SCUBA-2, supplemented by photometric data via on-source observations with ALMA, can allow to reconstruct the bright end of the SFR functions out to z ≤ 8. In parallel, such a challenging task can be managed by exploiting current UV surveys in combination with (sub-)mm observations by ALMA and NIKA2. The same could be done with radio observations by SKA and its precursors. In particular we have worked out predictions for the radio counts of star-forming galaxies down to nJy levels, along with redshift distributions down to the detection limits of the phase 1 Square Kilometer Array MID telescope (SKA1-MID) and of its precursors. To do that we exploited our SFR functions with relations between SFR and radio (synchrotron and free-free) emission. Our results show that the deepest SKA1- MID surveys will detect high-z galaxies with SFRs two orders of magnitude lower compared to Herschel surveys. The highest redshift tails of the distributions at the detection limits of planned SKA1-MID surveys comprise a substantial fraction of strongly lensed galaxies. The SKA1-MID will thus provide a comprehensive view of the star formation history throughout the re-ionization epoch, unaffected by dust extinction. We have also provided specific predictions for the EMU/ASKAP and MIGHTEE/MeerKAT surveys. We finally provide a novel, unifying physical interpretation on the origin, the average shape, the scatter, and the cosmic evolution for the main sequences (MS) of star-forming galaxies and active galactic nuclei at high redshift z ≥ 1. We achieve this goal in a model-independent way by exploiting the redshift-dependent SFR functions, and the deterministic evolutionary tracks for the history of star formation and black hole accretion, gauged on a wealth of multiwavelength observations including the observed Eddington ratio distribution. We further validate these ingredients by showing their consistency with the observed galaxy stellar mass functions and active galactic nucleus (AGN) bolometric luminosity functions at different redshifts via, again, the continuity equation approach. Our analysis of the main sequence for high-redshift galaxies and AGNs highlights that the present data strongly support a scenario of in situ coevolution for star formation and black hole accretion, envisaging these as local, time coordinated processes.

Herschel far-infrared photometry of the Swift Burst Alert Telescope active galactic nuclei sample of the local universe - III. Global star-forming properties and the lack of a connection to nuclear activity

NASA Astrophysics Data System (ADS)

Shimizu, T. Taro; Mushotzky, Richard F.; Meléndez, Marcio; Koss, Michael J.; Barger, Amy J.; Cowie, Lennox L.

2017-04-01

We combine the Herschel Space Observatory PACS (Photoconductor Array Camera and Spectrometer) and SPIRE (Spectral and Photometric Imaging Receiver) photometry with archival WISE (Wide-field Infrared Survey Explorer) photometry to construct the spectral energy distributions (SEDs) for over 300 local (z < 0.05), ultrahard X-ray (14-195 keV) selected active galactic nuclei (AGN) from the Swift Burst Alert Telescope (BAT) 58-month catalogue. Using a simple analytical model that combines an exponentially cutoff power law with a single temperature modified blackbody, we decompose the SEDs into a host galaxy and AGN component. We calculate dust masses, dust temperatures, and star formation rates (SFRs) for our entire sample and compare them to a stellar mass-matched sample of local non-AGN galaxies. We find AGN host galaxies have systematically higher dust masses, dust temperatures, and SFRs due to the higher prevalence of late-type galaxies to host an AGN, in agreement with previous studies of the Swift/BAT AGN. We provide a scaling to convert X-ray luminosities into 8-1000 μm AGN luminosities, as well as determine the best mid-to-far IR colours for identifying AGN-dominated galaxies in the IR regime. We find that for nearly 30 per cent of our sample, the 70 μm emission contains a significant contribution from the AGN (>0.5), especially at higher luminosities (L14 - 195 keV > 1042.5 erg s-1). Finally, we measure the local SFR-AGN luminosity relationship, finding a slope of 0.18, large scatter (0.37 dex), and no evidence for an upturn at high AGN luminosity. We conclude with a discussion on the implications of our results within the context of galaxy evolution with and without AGN feedback.

GAS, STARS, AND STAR FORMATION IN ALFALFA DWARF GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang Shan; Haynes, Martha P.; Giovanelli, Riccardo

2012-06-15

We examine the global properties of the stellar and H I components of 229 low H I mass dwarf galaxies extracted from the ALFALFA survey, including a complete sample of 176 galaxies with H I masses <10{sup 7.7} M{sub Sun} and H I line widths <80 km s{sup -1}. Sloan Digital Sky Survey (SDSS) data are combined with photometric properties derived from Galaxy Evolution Explorer to derive stellar masses (M{sub *}) and star formation rates (SFRs) by fitting their UV-optical spectral energy distributions (SEDs). In optical images, many of the ALFALFA dwarfs are faint and of low surface brightness; onlymore » 56% of those within the SDSS footprint have a counterpart in the SDSS spectroscopic survey. A large fraction of the dwarfs have high specific star formation rates (SSFRs), and estimates of their SFRs and M{sub *} obtained by SED fitting are systematically smaller than ones derived via standard formulae assuming a constant SFR. The increased dispersion of the SSFR distribution at M{sub *} {approx}< 10{sup 8} M{sub Sun} is driven by a set of dwarf galaxies that have low gas fractions and SSFRs; some of these are dE/dSphs in the Virgo Cluster. The imposition of an upper H I mass limit yields the selection of a sample with lower gas fractions for their M{sub *} than found for the overall ALFALFA population. Many of the ALFALFA dwarfs, particularly the Virgo members, have H I depletion timescales shorter than a Hubble time. An examination of the dwarf galaxies within the full ALFALFA population in the context of global star formation (SF) laws is consistent with the general assumptions that gas-rich galaxies have lower SF efficiencies than do optically selected populations and that H I disks are more extended than stellar ones.« less

The FourStar Galaxy Evolution Survey (ZFOURGE): Ultraviolet to Far-infrared Catalogs, Medium-bandwidth Photometric Redshifts with Improved Accuracy, Stellar Masses, and Confirmation of Quiescent Galaxies to z ˜ 3.5

NASA Astrophysics Data System (ADS)

Straatman, Caroline M. S.; Spitler, Lee R.; Quadri, Ryan F.; Labbé, Ivo; Glazebrook, Karl; Persson, S. Eric; Papovich, Casey; Tran, Kim-Vy H.; Brammer, Gabriel B.; Cowley, Michael; Tomczak, Adam; Nanayakkara, Themiya; Alcorn, Leo; Allen, Rebecca; Broussard, Adam; van Dokkum, Pieter; Forrest, Ben; van Houdt, Josha; Kacprzak, Glenn G.; Kawinwanichakij, Lalitwadee; Kelson, Daniel D.; Lee, Janice; McCarthy, Patrick J.; Mehrtens, Nicola; Monson, Andrew; Murphy, David; Rees, Glen; Tilvi, Vithal; Whitaker, Katherine E.

2016-10-01

The FourStar galaxy evolution survey (ZFOURGE) is a 45 night legacy program with the FourStar near-infrared camera on Magellan and one of the most sensitive surveys to date. ZFOURGE covers a total of 400 arcmin2 in cosmic fields CDFS, COSMOS and UDS, overlapping CANDELS. We present photometric catalogs comprising >70,000 galaxies, selected from ultradeep K s -band detection images (25.5-26.5 AB mag, 5σ, total), and >80% complete to K s < 25.3-25.9 AB. We use 5 near-IR medium-bandwidth filters (J 1, J 2, J 3, H s , H l ) as well as broad-band K s at 1.05-2.16 μm to 25-26 AB at a seeing of ˜0.″5. Each field has ancillary imaging in 26-40 filters at 0.3-8 μm. We derive photometric redshifts and stellar population properties. Comparing with spectroscopic redshifts indicates a photometric redshift uncertainty σ z = 0.010, 0.009, and 0.011 in CDFS, COSMOS, and UDS. As spectroscopic samples are often biased toward bright and blue sources, we also inspect the photometric redshift differences between close pairs of galaxies, finding σ z,pairs = 0.01-0.02 at 1 < z < 2.5. We quantify how σ z,pairs depends on redshift, magnitude, spectral energy distribution type, and the inclusion of FourStar medium bands. σ z,pairs is smallest for bright, blue star-forming samples, while red star-forming galaxies have the worst σ z,pairs. Including FourStar medium bands reduces σ z,pairs by 50% at 1.5 < z < 2.5. We calculate star formation rates (SFRs) based on ultraviolet and ultradeep far-IR Spitzer/MIPS and Herschel/PACS data. We derive rest-frame U - V and V - J colors, and illustrate how these correlate with specific SFR and dust emission to z = 3.5. We confirm the existence of quiescent galaxies at z ˜ 3, demonstrating their SFRs are suppressed by > ×15. This paper contains data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas observatory, Chile

INTER- AND INTRA-CLUSTER AGE GRADIENTS IN MASSIVE STAR FORMING REGIONS AND INDIVIDUAL NEARBY STELLAR CLUSTERS REVEALED BY MYStIX

NASA Astrophysics Data System (ADS)

Getman, Konstantin V.; Feigelson, Eric; Kuhn, Michael A.; Broos, Patrick S; Townsley, Leisa K.; Naylor, Tim; Povich, Matthew S.; Luhman, Kevin; Garmire, Gordon

2014-08-01

The MYStIX (Massive Young Star-Forming Complex Study in Infrared and X-ray) project seeks to characterize 20 OB-dominated young star forming regions (SFRs) at distances <4 kpc using photometric catalogs from the Chandra X-ray Observatory, Spitzer Space Telescope, UKIRT and 2MASS surveys. As part of the MYStIX project, we developed a new stellar chronometer that employs near-infrared and X-ray photometry data, AgeJX. Computing AgeJX averaged over MYStIX (sub)clusters reveals previously unknown age gradients across most of the MYStIX regions as well as within some individual rich clusters. Within the SFRs, the inferred AgeJX ages are youngest in obscured locations in molecular clouds, intermediate in revealed stellar clusters, and oldest in distributed stellar populations. Noticeable intra-cluster gradients are seen in the NGC 2024 (Flame Nebula) star cluster and the Orion Nebula Cluster (ONC): stars in cluster cores appear younger and thus were formed later than stars in cluster halos. The latter result has two important implications for the formation of young stellar clusters. Clusters likely form slowly: they do not arise from a single nearly-instantaneous burst of star formation. The simple models where clusters form inside-out are likely incorrect, and more complex models are needed. We provide several star formation scenarios that alone or in combination may lead to the observed core-halo age gradients.

Nuclear fuel requirements for the American economy - A model

NASA Astrophysics Data System (ADS)

Curtis, Thomas Dexter

A model is provided to determine the amounts of various fuel streams required to supply energy from planned and projected nuclear plant operations, including new builds. Flexible, user-defined scenarios can be constructed with respect to energy requirements, choices of reactors and choices of fuels. The model includes interactive effects and extends through 2099. Outputs include energy provided by reactors, the number of reactors, and masses of natural Uranium and other fuels used. Energy demand, including electricity and hydrogen, is obtained from US DOE historical data and projections, along with other studies of potential hydrogen demand. An option to include other energy demand to nuclear power is included. Reactor types modeled include (thermal reactors) PWRs, BWRs and MHRs and (fast reactors) GFRs and SFRs. The MHRs (VHTRs), GFRs and SFRs are similar to those described in the 2002 DOE "Roadmap for Generation IV Nuclear Energy Systems." Fuel source choices include natural Uranium, self-recycled spent fuel, Plutonium from breeder reactors and existing stockpiles of surplus HEU, military Plutonium, LWR spent fuel and depleted Uranium. Other reactors and fuel sources can be added to the model. Fidelity checks of the model's results indicate good agreement with historical Uranium use and number of reactors, and with DOE projections. The model supports conclusions that substantial use of natural Uranium will likely continue to the end of the 21st century, though legacy spent fuel and depleted uranium could easily supply all nuclear energy demand by shifting to predominant use of fast reactors.

Delayed or No Feedback? Gas Outflows in Type 2 AGNs. III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woo, Jong-Hak; Son, Donghoon; Bae, Hyun-Jin, E-mail: woo@astro.snu.ac.kr, E-mail: hjbae@galaxy.yonsei.ac.kr

2017-04-20

We present gas kinematics based on the [O iii] λ 5007 line and their connection to galaxy gravitational potential, active galactic nucleus (AGN) energetics, and star formation, using a large sample of ∼110,000 AGNs and star-forming (SF) galaxies at z < 0.3. Gas and stellar velocity dispersions are comparable to each other in SF galaxies, indicating that the ionized gas kinematics can be accounted by the gravitational potential of host galaxies. In contrast, AGNs clearly show non-gravitational kinematics, which is comparable to or stronger than the virial motion caused by the gravitational potential. The [O iii] velocity–velocity dispersion (VVD) diagrammore » dramatically expands toward high values as a function of AGN luminosity, implying that the outflows are AGN-driven, while SF galaxies do not show such a trend. We find that the fraction of AGNs with a signature of outflow kinematics, steeply increases with AGN luminosity and Eddington ratio. In particular, the majority of luminous AGNs presents strong non-gravitational kinematics in the [O iii] profile. AGNs with strong outflow signatures show on average similar specific star formation rates (sSFRs) to those of star-forming galaxies. In contrast, AGNs with weak or no outflows have an order of magnitude lower sSFRs, suggesting that AGNs with current strong outflows do now show any negative AGN feedback and that it may take dynamical time to impact on star formation over galactic scales.« less

Deep ALMA photometry of distant X-ray AGN: improvements in star formation rate constraints, and AGN identification

NASA Astrophysics Data System (ADS)

Stanley, F.; Harrison, C. M.; Alexander, D. M.; Simpson, J.; Knudsen, K. K.; Mullaney, J. R.; Rosario, D. J.; Scholtz, J.

2018-05-01

We present the star formation rates (SFRs) of a sample of 109 galaxies with X-ray selected active galactic nuclei (AGN) with moderate to high X-ray luminosities (\\mathrel {L_2-8{keV}}= 10^{42} - 10^{45} \\mathrel {erg {} s^{-1}}), at redshifts 1 < z < 4.7, that were selected to be faint or undetected in the Herschel bands. We combine our deep ALMA continuum observations with deblended 8-500\\mathrel {μ m} photometry from Spitzer and Herschel, and use infrared (IR) SED fitting and AGN - star formation decomposition methods. The addition of the ALMA photometry results in an order of magnitude more X-ray AGN in our sample with a measured SFR (now 37 per cent). The remaining 63 per cent of the sources have SFR upper limits that are typically a factor of 2-10 times lower than the pre-ALMA constraints. With the improved constraints on the IR SEDs, we can now identify a mid-IR (MIR) AGN component in 50 per cent of our sample, compared to only ˜1 per cent previously. We further explore the F_{870\\mathrel {μ m}}/F_{24\\mathrel {μ m}}-redshift plane as a tool for the identification of MIR emitting AGN, for three different samples representing AGN dominated, star formation dominated, and composite sources. We demonstrate that the F_{870\\mathrel {μ m}}/F_{24\\mathrel {μ m}}-redshift plane can successfully split between AGN and star formation dominated sources, and can be used as an AGN identification method.

The global star formation law of galaxies revisited in the radio continuum

NASA Astrophysics Data System (ADS)

Liu, LiJie; Gao, Yu

2012-02-01

We study the global star formation law, the relation between the gas and star formation rate (SFR) in a sample of 130 local galaxies with infrared (IR) luminosities spanning over three orders of magnitude (109-1012 L⊙), which includes 91 normal spiral galaxies and 39 (ultra)luminous IR galaxies [(U)LIRGs]. We derive their total (atomic and molecular) gas and dense molecular gas masses using newly available HI, CO and HCN data from the literature. The SFR of galaxies is determined from total IR (8-1000 μm) and 1.4 GHz radio continuum (RC) luminosities. The galaxy disk sizes are defined by the de-convolved elliptical Gaussian FWHM of the RC maps. We derive the galaxy disk-averaged SFRs and various gas surface densities, and investigate their relationships. We find that the galaxy disk-averaged surface density of dense molecular gas mass has the tightest correlation with that of SFR (scatter ˜0.26 dex), and is linear in log-log space (power-law slope of N=1.03±0.02) across the full galaxy sample. The correlation between the total gas and SFR surface densities for the full sample has a somewhat larger scatter (˜0.48 dex), and is best fit by a power-law with slope 1.45±0.02. However, the slope changes from ˜1 when only normal spirals are considered, to ˜1.5 when more and more (U)LIRGs are included in the fitting. When different CO-to-H2 conversion factors are used to infer molecular gas masses for normal galaxies and (U)LIRGs, the bi-modal relations claimed recently in CO observations of high-redshift galaxies appear to also exist in local populations of star-forming galaxies.

Star-Forming Regions in Orion as a Dust Evolution Laboratory

NASA Astrophysics Data System (ADS)

Wiebe, D.; Murga, M.; Sivkova, E.

2017-06-01

Star-forming regions (SFR) represent a convenient opportunity to study various processes related both to dust growth and to dust destruction. While extragalactic SFRs allow considering these processes in a wide range of metallicities, UV field intensities, etc., the Orion star-forming complex opens up a possibility to observe dust evolution with an unprecedented angular resolution. We review various observations related to dust evolution in some most prominent Orion regions, paying special attention to organic dust evolution, and introduce a new model of organic dust evolution.

Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor.

PubMed

Yamazaki, Yuji; Kubota, Hiroshi; Nozaki, Masami; Nagata, Kazuhiro

2003-08-15

The chaperonin-containing t-complex polypeptide 1 (CCT) is a molecular chaperone that facilitates protein folding in eukaryotic cytosol, and the expression of CCT is highly dependent on cell growth. We show here that transcription of the gene encoding the theta subunit of mouse CCT, Cctq, is regulated by the ternary complex factors (TCFs), Elk-1, Sap-1a, and Net (Sap-2). Reporter gene assay using HeLa cells indicated that the Cctq gene promoter contains a cis-acting element of the CCGGAAGT sequence (CQE1) at -36 bp. The major CQE1-binding proteins in HeLa cell nuclear extract was recognized by anti-Elk-1 or anti-Sap-1a antibodies in electrophoretic mobility shift assay, and recombinant Elk-1, Sap-1a, or Net specifically recognized CQE1. The CQE1-dependent transcriptional activity in HeLa cells was virtually abolished by overexpression of the DNA binding domains of TCFs. Overexpression of full-length TCFs with Ras indicated that exogenous TCFs can regulate the CQE1-dependent transcription in a Ras-dependent manner. PD98059, an inhibitor of MAPK, significantly repressed the CQE1-dependent transcription. However, no serum response factor was detected by electrophoretic mobility shift assay using the CQE1 element. These results indicate that transcription of the Cctq gene is regulated by TCFs under the control of the Ras/MAPK pathway, probably independently of serum response factor.

Family Factors Affecting Retention: A Review of the Literature

DTIC Science & Technology

1989-03-01

leadership has begun to recognize that career and reenlistment decisions are often family decisions, research incorporating family factors have...tentative links among these factors and between these factors and retention. There is much to be learned in order to provide Army leadership with the...questions are tied to key policy questions that Army leadership has asked of the AFRP. Rsac QLuestions: 1. What family factors inmact on retention? 2

From Cosmic Dusk till Dawn with RELICS

NASA Astrophysics Data System (ADS)

Bradac, Marusa

When did galaxies start forming stars? What is the role of distant galaxies in galaxy formation models and the epoch of reionization? What are the conditions in typical lowmass, star-forming galaxies at z 4? Why is galaxy evolution dependent on environment? Recent observations indicate several critical puzzles in studies that address these questions. Chief among these, galaxies might have started forming stars earlier than previously thought (<400Myr after the Big Bang) and their star formation history differs from what is predicted from simulations. Furthermore, the details of the mechanisms that regulate star formation and morphological transformation in dense environments are still unknown. To solve these puzzles of galaxy evolution, we will use 41 galaxy clusters from the RELICS program (Reionization Lensing Cluster Survey) that are among the most powerful cosmic telescopes. Their magnification will allow us to study stellar properties of a large number of galaxies all the way to the reionization era. Accurate knowledge of stellar masses, ages, and star formation rates (SFRs) requires measuring both rest-frame UV and optical light, which only Spitzer can probe at z>0.5-11 for a sufficiently large sample of typical galaxies. This program will combine Spitzer imaging from two large programs, Director Discretionary Time (DDT) and the SRELICS program led by the PI.The main challenge in a study such as this is the capability to perform reliable photometry in crowded fields. Our team recently helped develop TPHOT, which is a much improved and much faster version of previously available codes. TPHOT is specifically designed to extract fluxes in crowded fields with very different PSFs. We will combine Spitzer photometry with ground based imaging and spectroscopy to obtain robust measurements of galaxy star formation rates, stellar masses, and stellar ages. This program will be a crucial legacy complement to previous Spitzer/IRAC deep blank field surveys and cluster studies, and will open up new parameter space by probing intrinsically fainter objects than most current surveys with a significantly improved sample variance over deep field surveys. It will allow us to study the properties (e.g. SFRs and stellar masses) of a large number of galaxies (200 at z=6-10), thus meeting our goal of reconstructing the cosmic SFR density with sufficient precision to better understand the role of galaxies in the reionization process. We will measure the presence (or absence) of established stellar populations with Spitzer for the largest sample to date. Furthermore this proposal will allow us to study the SFRs of the intrinsically faint (and magnified) intermediate redshift (z 4) galaxies, as well as the stellar mass function of z=0.3-0.7 galaxy members of our cluster sample, thereby expanding our understanding of star formation from reionization to the epoch of galaxy formation and dense environments. Many of the science goals of this proposal are main science drivers for JWST. Due to magnification our effective depth and resolution match those of the JWST blank fields and affords us a sneak preview of JWST sources with Spitzer now. This program will thus provide a valuable test-bed for simulations, observation planning and source selection just in time for JWST Cycle 1.

Connections between Star Cluster Populations and Their Host Galaxy Nuclear Rings

NASA Astrophysics Data System (ADS)

Ma, Chao; de Grijs, Richard; Ho, Luis C.

2018-04-01

Nuclear rings are excellent laboratories for probing diverse phenomena such as the formation and evolution of young massive star clusters and nuclear starbursts, as well as the secular evolution and dynamics of their host galaxies. We have compiled a sample of 17 galaxies with nuclear rings, which are well resolved by high-resolution Hubble and Spitzer Space Telescope imaging. For each nuclear ring, we identified the ring star cluster population, along with their physical properties (ages, masses, and extinction values). We also determined the integrated ring properties, including the average age, total stellar mass, and current star formation rate (SFR). We find that Sb-type galaxies tend to have the highest ring stellar mass fraction with respect to the host galaxy, and this parameter is correlated with the ring’s SFR surface density. The ring SFRs are correlated with their stellar masses, which is reminiscent of the main sequence of star-forming galaxies. There are striking correlations between star-forming properties (i.e., SFR and SFR surface density) and nonaxisymmetric bar parameters, appearing to confirm previous inferences that strongly barred galaxies tend to have lower ring SFRs, although the ring star formation histories turn out to be significantly more complicated. Nuclear rings with higher stellar masses tend to be associated with lower cluster mass fractions, but there is no such relation for the ages of the rings. The two youngest nuclear rings in our sample, NGC 1512 and NGC 4314, which have the most extreme physical properties, represent the young extremity of the nuclear ring age distribution.

The Influence of Neonatal Nursery Design on Mothers' Interactions in the Nursery.

PubMed

Jones, Liz; Peters, Kathryn; Rowe, Jennifer; Sheeran, Nicola

2016-01-01

This study examined the influence of neonatal nursery design on interactions between nurses and mothers of infants in the nursery. We used a natural quasi-experimental design, using semi-structured interviews and a structured measure of mothers' and nurses' perceptions of nursing care, to compare mothers (n=26 and n=40) and nurses (n=22 and n=29) in an open-bay (OB) nursery and a single family room (SFR) nursery. Thematic analysis was used to generate key themes from the interviews. Mothers and nurses in both nursery designs talked about Valuing interactions; the importance of interactions between mothers and nurses. Mothers and nurses described SFRs as providing a space, My/their room, which enhanced mothers' sense of control and connection with the infant. SFRs were also associated with Changing the norms of interactions with nurses and other mothers, which created challenges in the desired quantity and quality of interactions for mothers and nurses. Nurses in the SFR nursery also reported Enhanced interactions, including improved confidentiality and personalized communication. Mothers in the OB nursery reported more supportive mothering actions from nurses than mothers in the SFR nursery. Both mothers and nurses in the OB nursery also talked about Our nursery community, which captured the value of having other nurses and mothers in the rooms. Mothers and nurses perceived that the SFR nursery enhanced privacy and maternal closeness for mothers compared to the OB nursery. However, the SFR nursery design presented challenges to some interactions of value to nurses and mothers. Copyright © 2016 Elsevier Inc. All rights reserved.

Demographics of Star-forming Galaxies since z ∼ 2.5. I. The UVJ Diagram in CANDELS

NASA Astrophysics Data System (ADS)

Fang, Jerome J.; Faber, S. M.; Koo, David C.; Rodríguez-Puebla, Aldo; Guo, Yicheng; Barro, Guillermo; Behroozi, Peter; Brammer, Gabriel; Chen, Zhu; Dekel, Avishai; Ferguson, Henry C.; Gawiser, Eric; Giavalisco, Mauro; Kartaltepe, Jeyhan; Kocevski, Dale D.; Koekemoer, Anton M.; McGrath, Elizabeth J.; McIntosh, Daniel; Newman, Jeffrey A.; Pacifici, Camilla; Pandya, Viraj; Pérez-González, Pablo G.; Primack, Joel R.; Salmon, Brett; Trump, Jonathan R.; Weiner, Benjamin; Willner, S. P.; Acquaviva, Viviana; Dahlen, Tomas; Finkelstein, Steven L.; Finlator, Kristian; Fontana, Adriano; Galametz, Audrey; Grogin, Norman A.; Gruetzbauch, Ruth; Johnson, Seth; Mobasher, Bahram; Papovich, Casey J.; Pforr, Janine; Salvato, Mara; Santini, P.; van der Wel, Arjen; Wiklind, Tommy; Wuyts, Stijn

2018-05-01

This is the first in a series of papers examining the demographics of star-forming (SF) galaxies at 0.2 < z < 2.5 in CANDELS. We study 9100 galaxies from GOODS-S and UDS, having published values of redshifts, masses, star formation rates (SFRs), and dust attenuation (A V ) derived from UV–optical spectral energy distribution fitting. In agreement with previous works, we find that the UVJ colors of a galaxy are closely correlated with its specific star formation rate (SSFR) and A V . We define rotated UVJ coordinate axes, termed S SED and C SED, that are parallel and perpendicular to the SF sequence and derive a quantitative calibration that predicts SSFR from C SED with an accuracy of ∼0.2 dex. SFRs from UV–optical fitting and from UV+IR values based on Spitzer/MIPS 24 μm agree well overall, but systematic differences of order 0.2 dex exist at high and low redshifts. A novel plotting scheme conveys the evolution of multiple galaxy properties simultaneously, and dust growth, as well as star formation decline and quenching, exhibit “mass-accelerated evolution” (“downsizing”). A population of transition galaxies below the SF main sequence is identified. These objects are located between SF and quiescent galaxies in UVJ space, and have lower A V and smaller radii than galaxies on the main sequence. Their properties are consistent with their being in transit between the two regions. The relative numbers of quenched, transition, and SF galaxies are given as a function of mass and redshift.

Exploring Damped Ly Alpha System Host Galaxies Using Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Toy, Vicki L.; Cucchiara, Antonino; Veilleux, Sylvain; Fumagalli, Michele; Rafelski, Marc; Rahmati, Alireza; Cenko, S. Bradley; Capone, John I.; Pasham, Dheeraj R.

2016-01-01

We present a sample of 45 Damped Ly-Alpha system [DLA; H I-N is greater than or equal to 2 x 10(exp. 20) cm(exp. -2)] counterparts (33 detections, 12 upper limits) which host gamma-ray bursts (GRB-DLAs) in order to investigate star formation and metallicity within galaxies hosting DLAs. Our sample spans z is approx. 2 - 6 and is nearly three times larger than any previously detected DLA counterparts survey based on quasar line-of-sight searches (QSO-DLAs). We report star formation rates (SFRs) from rest-frame UV photometry and spectral energy distribution modeling. We find that DLA counterpart SFRs are not correlated with either redshift or H I column density. Thanks to the combination of Hubble Space Telescope and ground-based observations, we also investigate DLA host star formation efficiency. Our GRB-DLA counterpart sample spans both higher efficiency and low efficiency star formation regions compared to the local Kennicutt-Schmidt relation, local star formation laws, and z is approximately 3 cosmological simulations. We also compare the depletion times of our DLA hosts sample to other objects in the local universe; our sample appears to deviate from the star formation efficiencies measured in local spiral and dwarf galaxies. Furthermore, we find similar efficiencies as local inner disks, SMC, and Lyman-break galaxy outskirts. Finally, our enrichment time measurements show a spread of systems with under- and over-abundance of metals, which may suggest that these systems had episodic star formation and a metal enrichment/depletion as a result of strong stellar feedback and/or metal inflow/outflow.

The Search for AGN in Dusty Star Forming Hosts with JWST

NASA Astrophysics Data System (ADS)

Kirkpatrick, Allison; Alberts, Stacey; Pope, Alexandra; Rieke, George; Sajina, Anna

2018-01-01

The bulk of the stellar growth over cosmic time is dominated by IR luminous galaxies at cosmic noon (z=1-2), many of which harbor a hidden active galactic nucleus (AGN). I use state of the art infrared color diagnostics, combining Spitzer and Herschel observations, to separate dust-obscured AGN from dusty star forming galaxies (SFGs) in the CANDELS and COSMOS surveys. I calculate 24 micron counts of SFGs, AGN/star forming "Composites", and AGN. AGN and Composites dominate the counts above 0.8 mJy at 24 micron, and Composites form at least 25% of an IR sample even to faint detection limits. I develop methods to use the Mid-Infrared Instrument (MIRI) on JWST to identify dust-obscured AGN and Composite galaxies from z~1-2. I demonstrate that MIRI color techniques can select AGN with lower Eddington ratios and higher specific SFRs than X-ray techniques alone. JWST/MIRI will enable critical steps forward in identifying and understanding dust-obscured AGN and the link to their host galaxies.

Lactic acid production from Sophora flavescens residues pretreated with sodium hydroxide: Reutilization of the pretreated liquor during fermentation.

PubMed

Wang, Juan; Gao, Ming; Liu, Jianguo; Wang, Qunhui; Wang, Cong; Yin, Zihe; Wu, Chuanfu

2017-10-01

The feasibility of lactic acid production from Sophora flavescens residues (SFRs) pretreated with sodium hydroxide with the reutilization of the pretreated liquor during fermentation was investigated. After sodium hydroxide pretreatment, 67.5% of the lignin was removed, and hydrolysis efficiency increased from 37.3% to 79.2%. The reutilization of pretreated liquor at 50% loading during open fermentation of unwashed SFR increased lactic acid production by 34.1%. The pretreated liquor acted as pH buffer and resulted in stable pH and high cellulase activity during fermentation. Inhibitors in the pretreated liquor did not affect the growth of lactic acid bacteria but severely inhibited the growth of ethanol-producing yeast. Consequently, lactic acid production increased and ethanol production was zero at 50% loading. Water consumption during pretreatment and fermentation with 50% pretreated liquor was 1.341L per 100g SFR, which was 67.6% lower than that during fermentation with washed SFR. Copyright © 2017 Elsevier Ltd. All rights reserved.

Risk Factors in the Pediatric Ward Recognized by Students Before Pediatric Nursing Practice －Basic Data for Medical Safety Education Based on Student's Learning Readiness－.

PubMed

Hirowatari, Kanako; Nakamura, Emi

2016-09-01

The purpose of this study was to extract the risk factors recognized by students before pediatric nursing practice in order to conduct medical safety education based on student's learning readiness. Third-year nursing students of A nursing college used the P-mSHELL model to find the risk factors in a simulated pediatric hospital room, and the researchers analyzed the contents. The students recognized four categories of risk factors: "burden on the family", "characteristics of the infant", "characteristics of children with disease", and "the family's cognition and understanding". There were three categories of risk factors related to "the environment": "environment that can cause a dangerous action", "unsafe environment", and "sickroom as a living space". There were four categories of risk factors related to "the student": "students' own physical/mental condition", "anxiety caused by pediatric nursing practice", "learning process in nursing practice" and "students' understanding of pediatric nursing". The students recognized that there were various risk factors in the child, the family, and the environment, and, by the P-mSHELL model, they recognized that they themselves could become a risk factor. Based on the risk factors that students extracted, teachers should think about what kind of preparation is necessary for students in pediatric nursing practice, and it is important to conduct medical safety education.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brunett, A. J.; Fanning, T. H.

The United States has extensive experience with the design, construction, and operation of sodium cooled fast reactors (SFRs) over the last six decades. Despite the closure of various facilities, the U.S. continues to dedicate research and development (R&D) efforts to the design of innovative experimental, prototype, and commercial facilities. Accordingly, in support of the rich operating history and ongoing design efforts, the U.S. has been developing and maintaining a series of tools with capabilities that envelope all facets of SFR design and safety analyses. This paper provides an overview of the current U.S. SFR analysis toolset, including codes such asmore » SAS4A/SASSYS-1, MC2-3, SE2-ANL, PERSENT, NUBOW-3D, and LIFE-METAL, as well as the higher-fidelity tools (e.g. PROTEUS) being integrated into the toolset. Current capabilities of the codes are described and key ongoing development efforts are highlighted for some codes.« less

Differential expression of rheumatoid factor-associated cross-reactive idiotypes in Iranian seropositive and seronegative patients with rheumatoid arthritis.

PubMed

Mosayebi, Ghasem; Rizgar, Mageed; Gharagozloo, Soheila; Shokri, Fazel

2007-01-01

High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. In the present study a panel of monoclonal antibodies (mAb) recognizing RF-associated cross-reactive idiotypes (CRI) linked to the VH1 (G8), VH4 (LC1), VK3b (17-109) and a mAb recognizing the VK3 subgroup (C7) of immunoglobulin variable region (IgV) gene products were used to quantitate the level of expression of these gene products in serum and synovial fluid of 35 seropositive (SP) and 8 SN RA patients by capture ELISA. While the concentration and relative proportion of the IgV are recognized by the mAb G8, 17-109 and C7 were significantly higher in serum and synovial fluid of the SP RA, compared to the SN-RA patients (G8, p = 0.009; 17-109, p = 0.0001; C7, p = 0.001). The CRI recognized by the mAb LC1 was highly represented in serum and synovial fluid of the SN-RA patients. There have been no significant differences in the level of expression of these IgV gene products (other than the product recognized by C7 mAb in SP patients) between serum and synovial fluid of either group of patients. Our results suggest that the expressed repertoire of Ig VH and VK genes in these two subsets of RA is differentially regulated and may be influenced by selective mechanisms leading to positive or negative selection of certain genes.

Radio Identification of Millimeter-Bright Galaxies Detected in the AzTEC/ASTE Blank Field Survey

NASA Astrophysics Data System (ADS)

Hatsukade, Bunyo; Kohno, Kotaro; White, Glenn; Matsuura, Shuji; Hanami, Hitoshi; Shirahata, Mai; Nakanishi, Kouichiro; Hughes, David; Tamura, Yoichi; Iono, Daisuke; Wilson, Grant; Yun, Min

2008-10-01

We propose a deep 1.4-GHz imaging of millimeter-bright sources in the AzTEC/ASTE 1.1-mm blank field survey of AKARI Deep Field-South. The AzTEC/ASTE uncovered 37 sources, which are possibly at z > 2. We have obtained multi-wavelength data in this field, but the large beam size of AzTEC/ASTE (30 arcsec) prevents us from identifying counterparts. The aim of this proposal is to identify radio counterparts with higher-angular resolution. This enables us (i) To identifying optical/IR counterparts. It enables optical spectroscopy to determine precise redshifts, allowing us to derive SFRs, luminosity functions, clustering properties, mass of dark matter halos, etc. (ii) To constrain luminosity evolutions of SMGs by comparing of 1.4-GHz number counts (and luminosity functions) with luminosity evolution models. (iii) To estimate photometric redshifts from 1.4-GHz and 1.1-mm data using the radio-FIR flux correlation. In case of non-detection, we can put deep lower limits (3 sigma limit of z > 3). These information lead to the study of evolutionary history of SMGs, their relationship with other galaxy populations, contribution to the cosmic star formation history and the infrared background.

An amorphous silicon photodiode microfluidic chip to detect nanomolar quantities of HIV-1 virion infectivity factor.

PubMed

Vistas, Cláudia R; Soares, Sandra S; Rodrigues, Rogério M M; Chu, Virginia; Conde, João P; Ferreira, Guilherme N M

2014-08-07

A hydrogenated amorphous silicon (a-Si:H) photosensor was explored for the quantitative detection of a HIV-1 virion infectivity factor (Vif) at a detection limit in the single nanomolar range. The a-Si:H photosensor was coupled with a microfluidic channel that was functionalized with a recombinant single chain variable fragment antibody. The biosensor selectively recognizes HIV-1 Vif from human cell extracts.

Use of In Vitro Transcription System for Analysis of Corynebacterium glutamicum Promoters Recognized by Two Sigma Factors.

PubMed

Šilar, Radoslav; Holátko, Jiří; Rucká, Lenka; Rapoport, Andrey; Dostálová, Hana; Kadeřábková, Pavla; Nešvera, Jan; Pátek, Miroslav

2016-09-01

Promoter activities in Corynebacterium glutamicum strains with deletions of genes encoding sigma factors of RNA polymerase suggested that transcription from some promoters is controlled by two sigma factors. To prove that different sigma factors are involved in the recognition of selected Corynebacterium glutamicum promoters, in vitro transcription system was applied. It was found that a typical housekeeping promoter Pper interacts with the alternative sigma factor σ(B) in addition to the primary sigma factor σ(A). On the other way round, the σ(B)-dependent promoter of the pqo gene that is expressed mainly in the stationary growth phase was active also with σ(A). Some promoters of genes involved in stress responses (P1clgR, P2dnaK, and P2dnaJ2) were found to be recognized by two stress-responding sigma factors, σ(H) and σ(E). In vitro transcription system thus proved to be a useful direct technique for demonstrating the overlap of different sigma factors in recognition of individual promoters in C. glutamicum.

Authoritative School Climate, Number of Parents at Home, and Academic Achievement

ERIC Educational Resources Information Center

Huang, Francis L.; Eklund, Katie; Cornell, Dewey G.

2017-01-01

School climate is widely recognized as an important factor in promoting student academic achievement. The current study investigated the hypothesis that a demanding and supportive school climate, based on authoritative school climate theory, would serve as a protective factor for students living with 1 or no parents at home. Using a statewide…

A Multiwavelength Approach to the Star Formation Rate Estimation in Galaxies at Intermediate Redshifts

NASA Astrophysics Data System (ADS)

Cardiel, N.; Elbaz, D.; Schiavon, R. P.; Willmer, C. N. A.; Koo, D. C.; Phillips, A. C.; Gallego, J.

2003-02-01

We use a sample of seven starburst galaxies at intermediate redshifts (z~0.4 and 0.8) with observations ranging from the observed ultraviolet to 1.4 GHz, to compare the star formation rate (SFR) estimators that are used in the different wavelength regimes. We find that extinction-corrected Hα underestimates the SFR, and the degree of this underestimation increases with the infrared luminosity of the galaxies. Galaxies with very different levels of dust extinction as measured with SFRIR/SFR(Hα, uncorrected for extinction) present a similar attenuation A[Hα], as if the Balmer lines probed a different region of the galaxy than the one responsible for the bulk of the IR luminosity for large SFRs. In addition, SFR estimates derived from [O II] λ3727 match very well those inferred from Hα after applying the metallicity correction derived from local galaxies. SFRs estimated from the UV luminosities show a dichotomic behavior, similar to that previously reported by other authors in galaxies at z<~0.4. Here we extend this result up to z~0.8. Finally, one of the studied objects is a luminous compact galaxy (LCG) that may be suffering similar dust-enshrouded star formation episodes. These results highlight the relevance of quantifying the actual LIR of LCGs, as well as that of a much larger and generic sample of luminous infrared galaxies, which will be possible after the launch of SIRTF. Based on data obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. Based in part on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. Based in part on observations with the Infrared Space Observatory (ISO), an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, Netherlands, and United Kingdom) with the participation of ISAS and NASA.

The Maternal Microbiome and Pregnancy Outcomes that Impact Infant Health: A Review

PubMed Central

Mulle, Jennifer G.; Ferranti, Erin P.; Edwards, Sara; Dunn, Alexis B.; Corwin, Elizabeth J.

2015-01-01

The maternal microbiome is recognized as a key determinant of a range of important maternal and child health outcomes, and together with perinatal factors influences the infant microbiome. This manuscript provides a summary review of research investigating: (1) the role of the maternal microbiome in pregnancy outcomes known to adversely influence neonatal and infant health, including preterm birth, cardiometabolic complications of pregnancy such as preeclampsia and gestational diabetes, and excessive gestational weight gain; (2) factors with an established link to adverse pregnancy outcomes that are known to influence the composition of the maternal microbiome; and (3) strategies for promoting a healthy maternal microbiome, recognizing that much more research is needed in this area. PMID:26317856

Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp

DOE Office of Scientific and Technical Information (OSTI.GOV)

An, Sojin; Kim, Hanseong; Cho, Uhn-Soo

2015-09-04

CENP-A is a centromere-specific histone H3 variant that is required for kinetochore assembly and accurate chromosome segregation. For it to function properly, CENP-A must be specifically localized to centromeres. In fission yeast, Scm3sp and the Mis18 complex, composed of Mis16, Eic1, and Mis18, function as a CENP-ACnp1-specific chaperone and a recruiting factor, respectively, and together ensure accurate delivery of CENP-ACnp1 to centromeres. Although how Scm3sp specifically recognizes CENP-ACnp1 has been revealed recently, the recruiting mechanism of CENP-ACnp1 via the Mis18 complex remains unknown. In this study, we have determined crystal structures of Schizosaccharomyces japonicus Mis16 alone and in complex withmore » the helix 1 of histone H4 (H4α1). Crystal structures followed by mutant analysis and affinity pull-downs have revealed that Mis16 recognizes both H4α1 and Scm3sp independently within the CENP-ACnp1/H4:Scm3sp complex. This observation suggests that Mis16 gains CENP-ACnp1 specificity by recognizing both Scm3sp and histone H4. Our studies provide insights into the molecular mechanisms underlying specific recruitment of CENP-ACnp1/H4:Scm3sp into centromeres.« less

THE AROMATIC FEATURES IN VERY FAINT DWARF GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu Ronin; Hogg, David W.; Moustakas, John

2011-04-01

We present optical and mid-infrared photometry of a statistically complete sample of 29 dwarf galaxies (M{sub r} > - 15 mag) selected from the Sloan Digital Sky Survey (SDSS) spectroscopic sample and observed in the mid-infrared with Spitzer IRAC. This sample contains nearby (redshift {approx}<0.005) galaxies 3 mag fainter than previously studied samples. We compare our sample with other star-forming galaxies that have been observed with both IRAC and SDSS. We examine the relationship of the infrared color, [3.6]-[7.8], sensitive to polycyclic aromatic hydrocarbon (PAH) abundance and also hot dust and stellar continuum, with star formation rates (SFRs), oxygen abundances,more » and radiation hardness, all estimated by optical emission lines. Consistent with studies of more luminous dwarfs, we find that these dwarf galaxies show much redder [3.6]-[7.8] color than luminous galaxies with similar specific SFRs. Unlike luminous galaxies, we find that these dwarf galaxies show no significant dependence at all of the [3.6]-[7.8] color on SFR, oxygen abundance, or radiation hardness, despite the fact that the sample spans a significant range in all of these quantities. When the dwarfs in our sample are compared with more luminous dwarfs, we find that the [3.6]-[7.8] color, potentially tracing the PAH emission, depends on oxygen abundance and radiation hardness. However, these two parameters are correlated with one another as well; we break this degeneracy by looking at the PAH-oxygen abundance relation at a fixed radiation hardness and the PAH-hardness relation at a fixed oxygen abundance. This test shows that the [3.6]-[7.8] color in dwarf galaxies appears to depend more directly on oxygen abundance based on the data currently available.« less

Gas, Stars, and Star Formation in Alfalfa Dwarf Galaxies

NASA Technical Reports Server (NTRS)

Huang, Shan; Haynes, Martha P.; Giovanelli, Riccardo; Brinchmann, Jarle; Stierwalt, Sabrina; Neff, Susan G.

2012-01-01

We examine the global properties of the stellar and Hi components of 229 low H i mass dwarf galaxies extracted from the ALFALFA survey, including a complete sample of 176 galaxies with H i masses <10(sup 7.7) solar mass and Hi line widths <80 kilometers per second. Sloan Digital Sky Survey (SDSS) data are combined with photometric properties derived from Galaxy Evolution Explorer to derive stellar masses (M*) and star formation rates (SFRs) by fitting their UV-optical spectral energy distributions (SEDs). In optical images, many of the ALFALFA dwarfs are faint and of low surface brightness; only 56% of those within the SDSS footprint have a counterpart in the SDSS spectroscopic survey. A large fraction of the dwarfs have high specific star formation rates (SSFRs), and estimates of their SFRs and M* obtained by SED fitting are systematically smaller than ones derived via standard formulae assuming a constant SFR. The increased dispersion of the SSFR distribution at M* approximately less than10(exp 8)M(sub 0) is driven by a set of dwarf galaxies that have low gas fractions and SSFRs; some of these are dE/dSphs in the Virgo Cluster. The imposition of an upper Hi mass limit yields the selection of a sample with lower gas fractions for their M* than found for the overall ALFALFA population. Many of the ALFALFA dwarfs, particularly the Virgo members, have H i depletion timescales shorter than a Hubble time. An examination of the dwarf galaxies within the full ALFALFA population in the context of global star formation (SF) laws is consistent with the general assumptions that gas-rich galaxies have lower SF efficiencies than do optically selected populations and that Hi disks are more extended than stellar ones.

EXPLORING SYSTEMATIC EFFECTS IN THE RELATION BETWEEN STELLAR MASS, GAS PHASE METALLICITY, AND STAR FORMATION RATE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Telford, O. Grace; Dalcanton, Julianne J.; Skillman, Evan D.

2016-08-10

There is evidence that the well-established mass–metallicity relation in galaxies is correlated with a third parameter: star formation rate (SFR). The strength of this correlation may be used to disentangle the relative importance of different physical processes (e.g., infall of pristine gas, metal-enriched outflows) in governing chemical evolution. However, all three parameters are susceptible to biases that might affect the observed strength of the relation between them. We analyze possible sources of systematic error, including sample bias, application of signal-to-noise ratio cuts on emission lines, choice of metallicity calibration, uncertainty in stellar mass determination, aperture effects, and dust. We presentmore » the first analysis of the relation between stellar mass, gas phase metallicity, and SFR using strong line abundance diagnostics from Dopita et al. for ∼130,000 star-forming galaxies in the Sloan Digital Sky Survey and provide a detailed comparison of these diagnostics in an appendix. Using these new abundance diagnostics yields a 30%–55% weaker anti-correlation between metallicity and SFR at fixed stellar mass than that reported by Mannucci et al. We find that, for all abundance diagnostics, the anti-correlation with SFR is stronger for the relatively few galaxies whose current SFRs are elevated above their past average SFRs. This is also true for the new abundance diagnostic of Dopita et al., which gives anti-correlation between Z and SFR only in the high specific star formation rate (sSFR) regime, in contrast to the recent results of Kashino et al. The poorly constrained strength of the relation between stellar mass, metallicity, and SFR must be carefully accounted for in theoretical studies of chemical evolution.« less

Clinical Nomograms to Predict Stone-Free Rates after Shock-Wave Lithotripsy: Development and Internal-Validation

PubMed Central

Kim, Jung Kwon; Ha, Seung Beom; Jeon, Chan Hoo; Oh, Jong Jin; Cho, Sung Yong; Oh, Seung-June; Kim, Hyeon Hoe; Jeong, Chang Wook

2016-01-01

Purpose Shock-wave lithotripsy (SWL) is accepted as the first line treatment modality for uncomplicated upper urinary tract stones; however, validated prediction models with regards to stone-free rates (SFRs) are still needed. We aimed to develop nomograms predicting SFRs after the first and within the third session of SWL. Computed tomography (CT) information was also modeled for constructing nomograms. Materials and Methods From March 2006 to December 2013, 3028 patients were treated with SWL for ureter and renal stones at our three tertiary institutions. Four cohorts were constructed: Total-development, Total-validation, CT-development, and CT-validation cohorts. The nomograms were developed using multivariate logistic regression models with selected significant variables in a univariate logistic regression model. A C-index was used to assess the discrimination accuracy of nomograms and calibration plots were used to analyze the consistency of prediction. Results The SFR, after the first and within the third session, was 48.3% and 68.8%, respectively. Significant variables were sex, stone location, stone number, and maximal stone diameter in the Total-development cohort, and mean Hounsfield unit (HU) and grade of hydronephrosis (HN) were additional parameters in the CT-development cohort. The C-indices were 0.712 and 0.723 for after the first and within the third session of SWL in the Total-development cohort, and 0.755 and 0.756, in the CT-development cohort, respectively. The calibration plots showed good correspondences. Conclusions We constructed and validated nomograms to predict SFR after SWL. To the best of our knowledge, these are the first graphical nomograms to be modeled with CT information. These may be useful for patient counseling and treatment decision-making. PMID:26890006

New approaches for MOX multi-recycling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gain, T.; Bouvier, E.; Grosman, R.

Due to its low fissile content after irradiation, Pu from used MOX fuel is considered by some as not recyclable in LWR (Light Water Reactors). The point of this paper is hence to go back to those statements and provide a new analysis based on AREVA extended experience in the fields of fissile and fertile material management and optimized waste management. This is done using the current US fuel inventory as a case study. MOX Multi-recycling in LWRs is a closed cycle scenario where U and Pu management through reprocessing and recycling leads to a significant reduction of the usedmore » assemblies to be stored. The recycling of Pu in MOX fuel is moreover a way to maintain the self-protection of the Pu-bearing assemblies. With this scenario, Pu content is also reduced repetitively via a multi-recycling of MOX in LWRs. Simultaneously, {sup 238}Pu content decreases. All along this scenario, HLW (High-Level Radioactive Waste) vitrified canisters are produced and planned for deep geological disposal. Contrary to used fuel, HLW vitrified canisters do not contain proliferation materials. Moreover, the reprocessing of used fuel limits the space needed on current interim storage. With MOX multi-recycling in LWR, Pu isotopy needs to be managed carefully all along the scenario. The early introduction of a limited number of SFRs (Sodium Fast Reactors) can therefore be a real asset for the overall system. A few SFRs would be enough to improve the Pu isotopy from used LWR MOX fuel and provide a Pu-isotopy that could be mixed back with multi-recycled Pu from LWRs, hence increasing the Pu multi-recycling potential in LWRs.« less

Using dust, gas and stellar mass-selected samples to probe dust sources and sinks in low-metallicity galaxies

NASA Astrophysics Data System (ADS)

De Vis, P.; Gomez, H. L.; Schofield, S. P.; Maddox, S.; Dunne, L.; Baes, M.; Cigan, P.; Clark, C. J. R.; Gomez, E. L.; Lara-López, M.; Owers, M.

2017-10-01

We combine samples of nearby galaxies with Herschel photometry selected on their dust, metal, H I and stellar mass content, and compare these to chemical evolution models in order to discriminate between different dust sources. In a companion paper, we used an H I-selected sample of nearby galaxies to reveal a subsample of very gas-rich (gas fraction >80 per cent) sources with dust masses significantly below predictions from simple chemical evolution models, and well below Md/M* and Md/Mgas scaling relations seen in dust and stellar-selected samples of local galaxies. We use a chemical evolution model to explain these dust-poor, but gas-rich, sources as well as the observed star formation rates (SFRs) and dust-to-gas ratios. We find that (I) a delayed star formation history is required to model the observed SFRs; (II) inflows and outflows are required to model the observed metallicities at low gas fractions; (III) a reduced contribution of dust from supernovae (SNe) is needed to explain the dust-poor sources with high gas fractions. These dust-poor, low stellar mass galaxies require a typical core-collapse SN to produce 0.01-0.16 M⊙ of dust. To match the observed dust masses at lower gas fractions, significant grain growth is required to counteract the reduced contribution from dust in SNe and dust destruction from SN shocks. These findings are statistically robust, though due to intrinsic scatter it is not always possible to find one single model that successfully describes all the data. We also show that the dust-to-metal ratio decreases towards lower metallicity.

SAM Theory Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Rui

The System Analysis Module (SAM) is an advanced and modern system analysis tool being developed at Argonne National Laboratory under the U.S. DOE Office of Nuclear Energy’s Nuclear Energy Advanced Modeling and Simulation (NEAMS) program. SAM development aims for advances in physical modeling, numerical methods, and software engineering to enhance its user experience and usability for reactor transient analyses. To facilitate the code development, SAM utilizes an object-oriented application framework (MOOSE), and its underlying meshing and finite-element library (libMesh) and linear and non-linear solvers (PETSc), to leverage modern advanced software environments and numerical methods. SAM focuses on modeling advanced reactormore » concepts such as SFRs (sodium fast reactors), LFRs (lead-cooled fast reactors), and FHRs (fluoride-salt-cooled high temperature reactors) or MSRs (molten salt reactors). These advanced concepts are distinguished from light-water reactors in their use of single-phase, low-pressure, high-temperature, and low Prandtl number (sodium and lead) coolants. As a new code development, the initial effort has been focused on modeling and simulation capabilities of heat transfer and single-phase fluid dynamics responses in Sodium-cooled Fast Reactor (SFR) systems. The system-level simulation capabilities of fluid flow and heat transfer in general engineering systems and typical SFRs have been verified and validated. This document provides the theoretical and technical basis of the code to help users understand the underlying physical models (such as governing equations, closure models, and component models), system modeling approaches, numerical discretization and solution methods, and the overall capabilities in SAM. As the code is still under ongoing development, this SAM Theory Manual will be updated periodically to keep it consistent with the state of the development.« less

Conjugative type IVb pilus recognizes lipopolysaccharide of recipient cells to initiate PAPI-1 pathogenicity island transfer in Pseudomonas aeruginosa

USDA-ARS?s Scientific Manuscript database

Pseudomonas aeruginosa pathogenicity island 1 (PAPI-1) is one of the largest genomic islands of this important opportunistic human pathogen. Previous studies have shown that PAPI-1 encodes several putative virulence factors, a major regulator of biofilm formation, and antibiotic-resistance traits, a...

A New, More Powerful Approach to Multitrait-Multimethod Analyses: An Application of Second-Order Confirmatory Factor Analysis.

ERIC Educational Resources Information Center

Marsh, Herbert W.; Hocevar, Dennis

The advantages of applying confirmatory factor analysis (CFA) to multitrait-multimethod (MTMM) data are widely recognized. However, because CFA as traditionally applied to MTMM data incorporates single indicators of each scale (i.e., each trait/method combination), important weaknesses are the failure to: (1) correct appropriately for measurement…

L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets.

PubMed

Colombo, Federico; Meldolesi, Jacopo

2015-11-01

L1 cell adhesion molecule (L1-CAM) and neural cell adhesion molecule (N-CAM), key members of the immunoglobulin-like CAM (Ig-CAM) family, were first recognized to play critical roles in surface interactions of neurons, by binding with each other and with extracellular matrix (ECM) proteins. Subsequently, adhesion was recognized to include signaling due to both activation of β-integrin, with the generation of intracellular cascades, and integration with the surface cytoskeleton. The importance of the two Ig-CAMs was revealed by their activation of the tyrosine kinase receptors of fibroblast growth factor (FGF), epidermal growth factor (EGF), and nerve growth factor (NGF). Based on these complex signaling properties, L1-CAM and N-CAM have become of great potential pharmacological interest in neurons and cancers. Treatment of neurodegenerative disorders and cognitive deficits of neurons is aimed to increase the cell Ig-CAM tone, possibly provided by synthetic/mimetic peptides. In cancer cells, where Ig-CAMs are often overexpressed, the proteins are employed for prognosis. The approaches to therapy are based on protein downregulation, antibodies, and adoptive immunotherapy. Copyright © 2015 Elsevier Ltd. All rights reserved.

Measuring Star-Formation Rates of AGNs and QSOs using a new calibration from Polycyclic Aromatic Hydrocarbon Emission

NASA Astrophysics Data System (ADS)

Papovich, Casey

Understanding the coevolution of star-formation and supermassive black hole accretion is one of the key questions in galaxy formation theory. This relation is important for understanding why at present the mass in galaxy bulges (on scales of kpc) correlates so tightly with the mass of galaxy central supermassive blackholes (on scales of AU). Feedback from supermassive black hole accretion may also be responsible for heating or expelling cold gas from galaxies, shutting off the fuel for star-formation and additional black hole growth. Did bulges proceed the formation of black holes, or vice versa, or are they contemporaneous? Therefore, understanding the exact rates of star-formation and supermassive black hole growth, and how they evolve with time and galaxy mass has deep implications for how galaxies form. It has previously been nearly impossible to study simultaneously both star-formation and accretion onto supermassive black holes in galaxies because the emission from black hole accretion contaminates nearly all diagnostics of star-formation. The "standard" diagnostics for the star-formation rate (the emission from hydrogen, UV emission, midIR emission, far-IR emission, etc) are not suitable for measuring star-formation rates in galaxies with actively accreting supermassive blackholes. In this proposal, the researchers request NASA/ADP funding for an archival study using spectroscopy with the Spitzer Space Telescope to measure simultaneously the star-formation rate (SFR) and bolometric emission from accreting supermassive blackholes to understand the complex relation between both processes. The key to this study is that they will develop a new calibrator for SFRs in galaxies with active supermassive black holes based on the molecular emission from polycyclic aromatic hydrocarbons (PAHs), which emit strongly in the mid-IR (3 - 20 micron) and are very strong in spectra from the Spitzer Space Telescope. The PAH molecules exist near photo-dissociation regions, and they re-emit a large fraction of the ionization radiation from ongoing star formation. Preliminary work using archival spectra from Spitzer show that the PAH luminosity scales linearly with the SFR with smaller scatter than "gold standard" SFR tracers, such as the (dust corrected) hydrogen emission. The PAH emission becomes important because they are destroyed by the hard UV radiation in the vicinity of accreting supermassive blackholes. Therefore, this makes the PAH emission extremely powerful: it has the unique ability to measure SFRs in galaxies with active supermassive black holes, where every other SFR indicator is contaminated by emission from the supermassive black hole. This objectives for this proposal are to (1) provide a robust recalibration of the SFR from the mid-IR PAH emission features using a large sample of star-forming galaxies in the Spitzer archive; (2) demonstrate the utility of the PAHs to derive valid SFRs from JWST observations, using archival Spitzer spectroscopy for distant galaxies strongly lensed gravitationally; finally, using a large sample of galaxies with Spitzer spectroscopy spanning a large range of total luminosity and AGN activity (from pure starbursts to quasars) to (3) measure the distribution function of the luminosity of star-formation, AGN, and test how these vary with total luminosity and redshift. Theoretical models make strong predictions for this distribution function. Comparing the data to these predictions allows us to test these models directly.

What factors influence ward nurses' recognition of and response to patient deterioration? An integrative review of the literature.

PubMed

Massey, Debbie; Chaboyer, Wendy; Anderson, Vinah

2017-01-01

In this integrative review, we aimed to: first, identify and summarize published studies relating to ward nurses' recognition of and response to patient deterioration; second, to critically evaluate studies that described or appraised the practice of ward nurses in recognizing and responding to patient deterioration; and third, identify gaps in the literature for further research. An integrative review. The Cumulative Index to Nursing and Allied Health Literature (CINAHL) Ovid Medline, Informit and Google Scholar databases were accessed for the years 1990-2014. Data were extracted and summarized in tables and then appraised using the Mixed Method Appraisal Tool. Data were grouped into two domains; recognizing and responding to deterioration and then thematic analysis was used to identify the emerging themes. Seventeen studies were reviewed and appraised. Recognizing patient deterioration was encapsulated in four themes: (1) assessing the patient; (2) knowing the patient; (3) education and (4) environmental factors. Responding to patient deterioration was encapsulated in three themes; (1) non-technical skills; (2) access to support and (3) negative emotional responses. Issues involved in timely recognition of and response to clinical deterioration remain complex, yet patient safety relies on nurses' timely assessments and actions.

Application of the SHARP Toolkit to Sodium-Cooled Fast Reactor Challenge Problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shemon, E. R.; Yu, Y.; Kim, T. K.

The Simulation-based High-efficiency Advanced Reactor Prototyping (SHARP) toolkit is under development by the Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign of the U.S. Department of Energy, Office of Nuclear Energy. To better understand and exploit the benefits of advanced modeling simulations, the NEAMS Campaign initiated the “Sodium-Cooled Fast Reactor (SFR) Challenge Problems” task, which include the assessment of hot channel factors (HCFs) and the demonstration of zooming capability using the SHARP toolkit. If both challenge problems are resolved through advanced modeling and simulation using the SHARP toolkit, the economic competitiveness of a SFR can be significantly improved. The effortsmore » in the first year of this project focused on the development of computational models, meshes, and coupling procedures for multi-physics calculations using the neutronics (PROTEUS) and thermal-hydraulic (Nek5000) components of the SHARP toolkit, as well as demonstration of the HCF calculation capability for the 100 MWe Advanced Fast Reactor (AFR-100) design. Testing the feasibility of the SHARP zooming capability is planned in FY 2018. The HCFs developed for the earlier SFRs (FFTF, CRBR, and EBR-II) were reviewed, and a subset of these were identified as potential candidates for reduction or elimination through high-fidelity simulations. A one-way offline coupling method was used to evaluate the HCFs where the neutronics solver PROTEUS computes the power profile based on an assumed temperature, and the computational fluid dynamics solver Nek5000 evaluates the peak temperatures using the neutronics power profile. If the initial temperature profile used in the neutronics calculation is reasonably accurate, the one-way offline method is valid because the neutronics power profile has weak dependence on small temperature variation. In order to get more precise results, the proper temperature profile for initial neutronics calculations was obtained from the STAR-CCM+ calculations. The HCFs of the peak temperatures at cladding outer surface, cladding inner wall surface, and fuel centerline induced by cladding manufacturing tolerance and uncertainties on the cladding, coolant, and fuel properties were evaluated for the AFR-100. Some assessment on the effect of wire wrap configuration and size of the bundle shows that it is practical to use the 7-pin bare rod bundle to calculate the HCFs. The resulting HCFs obtained from the high-fidelity SHARP calculations are generally smaller than those developed for the earlier SFRs because the most uncertainties involved in the modeling and simulations were disappeared. For completeness, additional investigations are planned in FY 2018, which will use random sampling techniques.« less

TLR-2 Recognizes Propionibacterium acnes CAMP Factor 1 from Highly Inflammatory Strains

PubMed Central

Ollagnier, Guillaume; Désiré, Nathalie; Sayon, Sophie; Raingeaud, Jöel; Marcelin, Anne-Geneviève; Calvez, Vincent; Khammari, Amir; Batteux, Frédéric; Dréno, Brigitte; Dupin, Nicolas

2016-01-01

Background Propionibacterium acnes (P. acnes) is an anaerobic, Gram-positive bacteria encountered in inflammatory acne lesions, particularly in the pilosebaceous follicle. P. acnes triggers a strong immune response involving keratinocytes, sebocytes and monocytes, the target cells during acne development. Lipoteicoic acid and peptidoglycan induce the inflammatory reaction, but no P. acnes surface protein interacting with Toll-like receptors has been identified. P. acnes surface proteins have been extracted by lithium stripping and shown to induce CXCL8 production by keratinocytes. Methodology and principal findings Far-western blotting identified two surface proteins, of 24.5- and 27.5-kDa in size, specifically recognized by TLR2. These proteins were characterized, by LC-MS/MS, as CAMP factor 1 devoid of its signal peptide sequence, as shown by N-terminal sequencing. Purified CAMP factor 1 induces CXCL8 production by activating the CXCL8 gene promoter, triggering the synthesis of CXCL8 mRNA. Antibodies against TLR2 significantly decreased the CXCL8 response. For the 27 P. acnes strains used in this study, CAMP1-TLR2 binding intensity was modulated and appeared to be strong in type IB and II strains, which produced large amounts of CXCL8, whereas most of the type IA1 and IA2 strains presented little or no CAMP1-TLR2 binding and low levels of CXCL8 production. The nucleotide sequence of CAMP factor displays a major polymorphism, defining two distinct genetic groups corresponding to CAMP factor 1 with 14 amino-acid changes from strains phylotyped II with moderate and high levels of CAMP1-TLR2 binding activity, and CAMP factor 1 containing 0, 1 or 2 amino-acid changes from strains phylotyped IA1, IA2, or IB presenting no, weak or moderate CAMP1-TLR2 binding. Conclusions Our findings indicate that CAMP factor 1 may contribute to P. acnes virulence, by amplifying the inflammation reaction through direct interaction with TLR2. PMID:27902761

TLR-2 Recognizes Propionibacterium acnes CAMP Factor 1 from Highly Inflammatory Strains.

PubMed

Lheure, Coralie; Grange, Philippe Alain; Ollagnier, Guillaume; Morand, Philippe; Désiré, Nathalie; Sayon, Sophie; Corvec, Stéphane; Raingeaud, Jöel; Marcelin, Anne-Geneviève; Calvez, Vincent; Khammari, Amir; Batteux, Frédéric; Dréno, Brigitte; Dupin, Nicolas

2016-01-01

Propionibacterium acnes (P. acnes) is an anaerobic, Gram-positive bacteria encountered in inflammatory acne lesions, particularly in the pilosebaceous follicle. P. acnes triggers a strong immune response involving keratinocytes, sebocytes and monocytes, the target cells during acne development. Lipoteicoic acid and peptidoglycan induce the inflammatory reaction, but no P. acnes surface protein interacting with Toll-like receptors has been identified. P. acnes surface proteins have been extracted by lithium stripping and shown to induce CXCL8 production by keratinocytes. Far-western blotting identified two surface proteins, of 24.5- and 27.5-kDa in size, specifically recognized by TLR2. These proteins were characterized, by LC-MS/MS, as CAMP factor 1 devoid of its signal peptide sequence, as shown by N-terminal sequencing. Purified CAMP factor 1 induces CXCL8 production by activating the CXCL8 gene promoter, triggering the synthesis of CXCL8 mRNA. Antibodies against TLR2 significantly decreased the CXCL8 response. For the 27 P. acnes strains used in this study, CAMP1-TLR2 binding intensity was modulated and appeared to be strong in type IB and II strains, which produced large amounts of CXCL8, whereas most of the type IA1 and IA2 strains presented little or no CAMP1-TLR2 binding and low levels of CXCL8 production. The nucleotide sequence of CAMP factor displays a major polymorphism, defining two distinct genetic groups corresponding to CAMP factor 1 with 14 amino-acid changes from strains phylotyped II with moderate and high levels of CAMP1-TLR2 binding activity, and CAMP factor 1 containing 0, 1 or 2 amino-acid changes from strains phylotyped IA1, IA2, or IB presenting no, weak or moderate CAMP1-TLR2 binding. Our findings indicate that CAMP factor 1 may contribute to P. acnes virulence, by amplifying the inflammation reaction through direct interaction with TLR2.

Knowledge of stroke among stroke patients and their relatives in Northwest India.

PubMed

Pandian, Jeyaraj Durai; Kalra, Guneet; Jaison, Ashish; Deepak, Sukhbinder Singh; Shamsher, Shivali; Singh, Yashpal; Abraham, George

2006-06-01

The knowledge of warning symptoms and risk factors for stroke has not been studied among patients with stroke in developing countries. We aimed to assess the knowledge of stroke among patients with stroke and their relatives. Prospective tertiary referral hospital-based study in Northwest India. Trained nurses and medical interns interviewed patients with stroke and transient ischemic attack and their relatives about their knowledge of stroke symptoms and risk factors. Univariable and multivariable logistic regression were used. Of the 147 subjects interviewed, 102 (69%) were patients and 45 (31%) were relatives. There were 99 (67%) men and 48 (33%) women and the mean age was 59.7+/-14.1 years. Sixty-two percent of respondents recognized paralysis of one side as a warning symptom and 54% recognized hypertension as a risk factor for stroke. In the multivariable logistic regression analysis, higher education was associated with the knowledge of correct organ involvement in stroke (OR 2.6, CI 1.1- 6.1, P =0.02), whereas younger age (OR 2.7, CI 1.1-7.0, P =0.04) and higher education (OR 4.1, CI 1.5-10.9, P =0.005) correlated with a better knowledge regarding warning symptoms of stroke. In this study cohort, in general, there is lack of awareness of major warning symptoms, risk factors, organ involvement and self-recognition of stroke. However younger age and education status were associated with better knowledge. There is an urgent need for awareness programs about stroke in this study cohort.

Insulin resistance, role of metformin and other noninsulin therapies in pediatric type 1 diabetes

USDA-ARS?s Scientific Manuscript database

Type 1 diabetes mellitus (T1DM) in youth is a challenging chronic medical condition. Its management should address not only the glycemic control but also insulin resistance and cardiovascular disease risk factors which are increasingly recognized to be present in youth with TID. Current knowledge on...

Self-Reported Discrimination in Health-Care Settings Based on Recognizability as Transgender: A Cross-Sectional Study Among Transgender U.S. Citizens.

PubMed

Rodriguez, Amanda; Agardh, Anette; Asamoah, Benedict Oppong

2018-05-01

Discrimination has long been tied to health inequality. Rejected by families and communities because of their gender identity and gender-role behavior, transgender individuals are often socially marginalized. This study aimed to assess discrimination in health-care settings among persons self-identifying as transgender in the U.S. in relation to their recognizability as transgender, operationalized as how often they experienced that others recognized them as transgender. Data were obtained from the National Transgender Discrimination Survey (n = 6106 participants, assigned sex at birth = 3608 males, 2480 females, respectively). Binary logistic regressions were performed to examine associations between transgender recognizability and discrimination in health-care settings. Being recognized as transgender to any extent had a significant effect on perceived discrimination in health care. Always recognized as transgender showed significant associations with discrimination in a health-care setting (OR 1.48) and the following individualized health-care settings: social service settings (rape crisis and domestic violence centers, OR 5.22) and mental health settings (mental health clinic and drug treatment program, OR 1.87). Sex work and other street economy, which are known experiential factors affected by discrimination, were also significantly associated with discrimination in health-care settings. Discrimination in health-care settings is pervasive for transgender who are recognized as transgender. Public health efforts to improve access to equitable health care for transgender individuals may benefit from consideration of demographic, experiential, and medical risk factors to more fully understand the source of the seemingly excess risk of discrimination among persons recognized by others as being transgender.

Correlation between donor age and organs transplanted per donor: our experience in Japan.

PubMed

Ashikari, J; Omiya, K; Konaka, S; Nomoto, K

2014-05-01

The shortage of available organs for transplantation is a worldwide issue. To maximize the number of transplantations, increasing the number of organs transplanted per donor (OTPD) is widely recognized as an important factor for improving the shortage. In Japan, we have had 211 donors, 1112 organs transplanted, and 924 recipients receiving the transplants, resulting in 4.4 ± 1.4 recipients receiving transplants per donor and 5.3 ± 1.6 OTPD as of February 2013. Because donor age is a well-recognized factor of donor suitability, we analyzed the correlation between donor age group and OTPD. Only the age group 60 to 69 years and the age group 70 to 79 years were significantly different (P < .05) from adjacent age groups. We estimate that a donor under age 70 years has the potential to donate 4.6 to 6.7 organs. Copyright © 2014 Elsevier Inc. All rights reserved.

Galaxy pairs in the Sloan Digital Sky Survey - VII. The merger-luminous infrared galaxy connection

NASA Astrophysics Data System (ADS)

Ellison, Sara L.; Mendel, J. Trevor; Scudder, Jillian M.; Patton, David R.; Palmer, Michael J. D.

2013-04-01

We use a sample of 9397 low-redshift (z ≤ 0.1) galaxies with a close companion to investigate the connection between mergers and luminous infrared (IR) galaxies (LIRGs). The pairs are selected from the Sloan Digital Sky Survey (SDSS) and have projected separations rp ≤ 80 h{^{- 1}_{70}} kpc, relative velocities ΔV ≤ 300 km s-1 and stellar mass ratios within a factor of 1:10. A control sample consisting of four galaxies per pair galaxy is constructed by simultaneously matching in stellar mass, redshift and environment to galaxies with no close companion. The IR luminosities (LIR) of galaxies in the pair and control samples are determined from the SDSS - Infrared Astronomical Satellite (IRAS) matched catalogue of Hwang et al. Over the redshift range of our pairs sample, the IRAS matches are complete to LIRG luminosities (LIR ≥ 1011 L⊙), allowing us to investigate the connection between mergers and luminous IR galaxies. We find a trend for increasing LIRG fraction towards smaller pair separations, peaking at a factor of ˜5-10 above the median control fraction at the smallest separations (rp < 20 h{^{- 1}_{70}} kpc), but remaining elevated by a factor ˜2-3 even out to 80 h{^{- 1}_{70}} kpc (the widest separations in our sample). LIRG pairs predominantly have high star formation rates (SFRs), high extinction and are found in relatively low-density environments, relative to the full pairs sample. We also find that LIRGs are most likely to be found in high-mass galaxies which have an approximately equal-mass companion. We confirm the results of previous studies that both the active galactic nucleus (AGN) fraction and merger fraction increase strongly as a function of IR luminosity. About 7 per cent of LIRGs are associated with major mergers, as defined within the criteria and mass completion of our sample. Finally, we quantify an SFR offset (ΔSFR) as the enhancement (or decrement) relative to star-forming galaxies of the same mass and redshift. We demonstrate that there is a clear connection between the ΔSFR and the classification of a galaxy as a LIRG that is mass dependent. Most of the LIRGs in our merger sample are relatively high-mass galaxies (log (M⋆/M⊙) > 10.5), likely because the SFR enhancement required to produce LIRG luminosities is more modest than at low masses. The ΔSFR offers a redshift-independent metric for the identification of the galaxies with the most enhanced star-forming rates that does not rely on fixed LIR boundaries.

Part 1--Factors Associated with School Nurse Ratios: An Analysis of State Data

ERIC Educational Resources Information Center

Maughan, Erin

2009-01-01

Despite the recognized importance of school nurses, the ratios of nurse to pupil are insufficient in many states across the country. The purpose of this study was to describe school nurse-to-pupil ratios by state and to statistically identify factors that may influence these ratios. Funding per pupil unit in general and support services and laws…

Molecular cytogenetic mapping of 24 CEPH YACs and 24 gene-specific large insert probes to chromosome 17.

PubMed

Bärlund, M; Nupponen, N N; Karhu, R; Tanner, M M; Paavola, P; Kallioniemi, O P; Kallioniemi, A

1998-01-01

Defining boundaries of chromosomal rearrangements at the molecular level would benefit from landmarks that link the cytogenetic map to physical, genetic, and transcript maps, as well as from large-insert FISH probes for such loci to detect numerical and structural rearrangements in metaphase or interphase cells. Here, we determined the locations of 24 genetically mapped CEPH-Mega YACs along the FLpter scale (fractional length from p-telomere) by quantitative fluorescence in situ hybridization analysis. This generated a set of cytogenetically mapped probes for chromosome 17 with an average spacing of about 5 cM. We then developed large-insert YAC, BAC, PAC, or P1 clones to the following 24 known genes, and determined refined map locations along the same FLpter scale: pter-TP53-TOP3-cen-TNFAIP1-ERBB2-TOP2A- BRCA1-TCF11-NME1-HLF-ZNF147/CL N80-BCL5/MPO/SFRS1-TBX2-PECAM1-DDX5/ PRKCA-ICAM2-GH1/PRKAR1A-GRB2-CDK3 /FKHL13-qter. Taken together, these 48 cytogenetically mapped large-insert probes provide tools for the molecular analysis of chromosome 17 rearrangements, such as mapping amplification, deletion, and translocation breakpoints in this chromosome, in cancer and other diseases.

Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts*

PubMed Central

Bai, Shuting; Zha, Jikun; Zhao, Haibo; Ross, F. Patrick; Teitelbaum, Steven L.

2008-01-01

Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-κB (RANK) and is an essential component of the signaling complex mediating osteoclastogenesis. However, the osteoclastic activity of TRAF6 is blunted by its association with four and half LIM domain 2 (FHL2), which functions as an adaptor protein in the cytoplasm and transcriptional regulator in the nucleus. We find that TRAF6 also localizes in the nuclei of osteoclasts but not their bone marrow macrophage precursors and that osteoclast intranuclear abundance is specifically increased by RANK ligand (RANKL). TRAF6 nuclear localization requires FHL2 and is diminished in fhl2-/- osteoclasts. Suggesting transcriptional activity, TRAF6 interacts with the transcription factor RUNX1 in the osteoclast nucleus. FHL2 also associates with RUNX1 but does so only in the presence of TRAF6. Importantly, TRAF6 recognizes FHL2 and RUNX1 in osteoclast nuclei, and the three molecules form a DNA-binding complex that recognizes and transactivates the RUNX1 response element in the fhl2 promoter. Finally, TRAF6 and its proximal activator, RANKL, polyubiquitinate FHL2, prompting its proteasomal degradation. These observations suggest a feedback mechanism whereby TRAF6 negatively regulates osteoclast formation by intracytoplasmic sequestration of FHL2 to blunt RANK activation and as a component of a transcription complex promoting FHL2 expression. PMID:18768464

The Reconstruction of Condition-Specific Transcriptional Modules Provides New Insights in the Evolution of Yeast AP-1 Proteins

PubMed Central

Goudot, Christel; Etchebest, Catherine

2011-01-01

AP-1 proteins are transcription factors (TFs) that belong to the basic leucine zipper family, one of the largest families of TFs in eukaryotic cells. Despite high homology between their DNA binding domains, these proteins are able to recognize diverse DNA motifs. In yeasts, these motifs are referred as YRE (Yap Response Element) and are either seven (YRE-Overlap) or eight (YRE-Adjacent) base pair long. It has been proposed that the AP-1 DNA binding motif preference relies on a single change in the amino acid sequence of the yeast AP-1 TFs (an arginine in the YRE-O binding factors being replaced by a lysine in the YRE-A binding Yaps). We developed a computational approach to infer condition-specific transcriptional modules associated to the orthologous AP-1 protein Yap1p, Cgap1p and Cap1p, in three yeast species: the model yeast Saccharomyces cerevisiae and two pathogenic species Candida glabrata and Candida albicans. Exploitation of these modules in terms of predictions of the protein/DNA regulatory interactions changed our vision of AP-1 protein evolution. Cis-regulatory motif analyses revealed the presence of a conserved adenine in 5′ position of the canonical YRE sites. While Yap1p, Cgap1p and Cap1p shared a remarkably low number of target genes, an impressive conservation was observed in the YRE sequences identified by Yap1p and Cap1p. In Candida glabrata, we found that Cgap1p, unlike Yap1p and Cap1p, recognizes YRE-O and YRE-A motifs. These findings were supported by structural data available for the transcription factor Pap1p (Schizosaccharomyces pombe). Thus, whereas arginine and lysine substitutions in Cgap1p and Yap1p proteins were reported as responsible for a specific YRE-O or YRE-A preference, our analyses rather suggest that the ancestral yeast AP-1 protein could recognize both YRE-O and YRE-A motifs and that the arginine/lysine exchange is not the only determinant of the specialization of modern Yaps for one motif or another. PMID:21695268

Confronting models of star formation quenching in galaxy clusters with archival Spitzer data

NASA Astrophysics Data System (ADS)

Rudnick, Gregory

Large scale structures in the universe form hierarchically: small structures merge to form larger ones. Over the same epoch where these structures experience significant growth, the fraction of star forming galaxies within them decreases, and at a faster rate than for field galaxies. It is now widely accepted that there must be physical processes at work in these dense environments to actively quench star formation. However, despite no shortage of candidate mechanisms, sophisticated cosmological simulations still cannot reproduce the star formation rate distributions within dense environments, such as galaxy clusters. Insufficient observational constraints are a primary obstacle to further progress. In particular, the interpretation of observations of nearby clusters relies on untested assumptions about the properties of galaxies before they entered the dense cluster environment at higher redshifts. Clearly, direct constraints on these properties are required. Our group has assembled two data sets designed to address these concerns. The first focuses on an intermediate wide-field cluster sample and the second focuses on a well-matched low-redshift cluster sample. We will use these samples, along with sophisticated models of hierarchical galaxy formation, to meet the following objectives: 1. Directly measure the SFR distribution of the progenitors of present-day cluster galaxies. We will use ground-based spectroscopy to identify cluster members within four virial radii of eight intermediate-redshift clusters. We will couple this with archival Spitzer/MIPS data to measure the SFRs of galaxies out to the cluster outskirts. 2. Measure the SFR distribution of the present-day cluster galaxies using Spitzer and WISE. Robust N-body simulations tell us statistically which galaxies at intermediate redshifts will have entered the cluster virial radius by the current epoch. By combining our wide-field coverage at high redshift with our local cluster sample, we will determine the evolution in cluster galaxy SFRs over 6 billion years making minimal assumptions about the infalling galaxy population. 3. Provide a rigorous test of the quenching processes embedded in the theoretical models. We will create observed realizations of the theoretical models by subjecting them to our observational selection. This will enable a fair comparison between the models and the data, which will provide a valuable test of current theoretical implementations of quenching processes. We will also modify the quenching prescriptions in the models to determine the parameters required to reproduce the observations. The proposed research is novel for several reasons. 1) We have wide-field Spitzer/MIPS data that allows us to robustly measure SFRs in our distant cluster galaxies. WISE data on local clusters will provide us with analogous measurements in the nearby Universe. 2) Our significant investment in ancillary spectroscopy allows us to identify infalling galaxies that will eventually join the central regions of the cluster z=0. 3) Our intermediate redshift cluster sample was chosen to have characteristics expected for the progenitors of a large fraction of the known clusters at z=0. 4) We will take advantage of our own cosmological simulations of structure growth to interpret our data. 5) We have optical photometry over the full infall region, allowing us to control for stellar masses and to distinguish passive from dusty star-forming galaxies. We will learn which, if any, of the quenching prescriptions currently employed in semi-analytic models correctly reproduces the observed characteristics of the galaxies that will become cluster galaxies at z=0. We will pinpoint the cluster-centric radii over which quenching takes place between. We will determine the timescale (as a function of stellar mass) over which it must take place. This program will cement the legacy of Spitzer and WISE as tools for studying galaxy formation in clusters.

Study of signal-to-noise ratio in digital mammography

NASA Astrophysics Data System (ADS)

Kato, Yuri; Fujita, Naotoshi; Kodera, Yoshie

2009-02-01

Mammography techniques have recently advanced from those using analog systems (the screen-film system) to those using digital systems; for example, computed radiography (CR) and flat-panel detectors (FPDs) are nowadays used in mammography. Further, phase contrast mammography (PCM)-a digital technique by which images with a magnification of 1.75× can be obtained-is now available in the market. We studied the effect of the air gap in PCM and evaluated the effectiveness of an antiscatter x-ray grid in conventional mammography (CM) by measuring the scatter fraction ratio (SFR) and relative signal-to-noise ratio (rSNR) and comparing them between PCM and the digital CM. The results indicated that the SFRs for the CM images obtained with a grid were the lowest and that these ratios were almost the same as those for the PCM images. In contrast, the rSNRs for the PCM images were the highest, which means that the scattering of x-rays was sufficiently reduced by the air gap without the loss of primary x-rays.

(Sub)millimetre-Selected Galaxies and the Cosmic Star-Formation History

NASA Astrophysics Data System (ADS)

Koprowski, Maciej

2015-03-01

Understanding the time evolution of the star formation in the Universe is one of the main aims of observational astronomy. Since a significant portion of the UV starlight is being absorbed by dust and re-emitted in the IR, we need to understand both of those regimes to properly describe the cosmic star formation history. In UV, the depth and the resolution of the data permits calculations of the star formation rate densities out to very high redshifts (z˜8-9). In IR however, the large beam sizes and the relatively shallow data limits these calculations to z˜2. In this thesis, I explore the SMA and PdBI high-resolution follow-up of 30 bright sources originally selected by AzTEC and LABOCA instruments at 1.1 mm and 870 μm respectively in conjunction with the SCUBA-2 Cosmology Legacy Survey (S2CLS) deep COSMOS and wide UDS maps, where 106 and 283 sources were detected, with the signal-to-noise ratio of > 5 and > 3.5 at 850 μm respectively. I find that the (sub)mm-selected galaxies reside and the mean redshifts of z ≈ 2.5±0.05 with the exception of the brightest sources which z seem to lie at higher redshifts (z ≈ 3.5±0.2), most likely due to the apparent z correlation of the (sub)mm flux with redshift, where brighter sources tend to lie at higher redshifts. Stellar masses, M\\dot, and star formation rates, SFRs, were found (M\\dot ≥ 10^10 M⊙ and SFR ≥ 100 M⊙ yr-1 ) and used to calculate the specific SFRs. I determine that the (sub)mm-selected sources mostly lie on the high-mass end of the star formation 'main-sequence' which makes them a high-mass extension of normal star forming galaxies. I also find that the specific SFR slightly evolves at redshifts 2 - 4, suggesting that the efficiency of the star formation seems to be increasing at these redshifts. Using the S2CLS data, the bolometric IR luminosity functions (IR LFs) were found for a range of redshifts z = 1.2 - 4.2 and the contribution of the SMGs tothe total star formation rate density (SFRD) was calculated. The IR LFs were found to evolve out to redshift ∼ 2.5. The star formation activity in the Universe was found to peak at z ≈ 2 followed by a slight decline. Assuming the IR to total SFRD correction found in the literature the SFRD found in this work closely follows the best-fitting function of Madau & Dickinson (2014).

THE EXTREMELY RED HOST GALAXY OF GRB 080207

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, Leslie; Cresci, Giovanni; Palazzi, Eliana

2011-08-01

We present optical, near-infrared, and Spitzer IRAC and MIPS observations of the host galaxy of the dark Swift gamma-ray burst GRB 080207. The host is faint, with extremely red optical-infrared colors (R - K = 6.3, 24 {mu}m/R-band flux {approx}1000) making it an extremely red object (ERO) and a dust-obscured galaxy (DOG). The spectral energy distribution (SED) shows the clear signature of the 1.6 {mu}m photometric 'bump', typical of evolved stellar populations. We use this bump to establish the photometric redshift z{sub phot} as 2.2{sup +0.2}{sub -0.3}, using a vast library of SED templates, including M 82. The star formationmore » rate (SFR) inferred from the SED fitting is {approx}119 M{sub sun} yr{sup -1}, the stellar mass 3 x 10{sup 11} M{sub sun}, and A{sub V} extinction from 1 to 2 mag. The ERO and DOG nature of the host galaxy of the dark GRB 080207 may be emblematic of a distinct class of dark GRB hosts, with high SFRs, evolved and metal-rich stellar populations, and significant dust extinction within the host galaxy.« less

Cold-mode Accretion: Driving the Fundamental Mass-Metallicity Relation at z ~ 2

NASA Astrophysics Data System (ADS)

Kacprzak, Glenn G.; van de Voort, Freeke; Glazebrook, Karl; Tran, Kim-Vy H.; Yuan, Tiantian; Nanayakkara, Themiya; Allen, Rebecca J.; Alcorn, Leo; Cowley, Michael; Labbé, Ivo; Spitler, Lee; Straatman, Caroline; Tomczak, Adam

2016-07-01

We investigate the star formation rate (SFR) dependence on the stellar mass and gas-phase metallicity relation at z = 2 with MOSFIRE/Keck as part of the ZFIRE survey. We have identified 117 galaxies (1.98 ≤ z ≤ 2.56), with 8.9 ≤ log(M/M ⊙) ≤ 11.0, for which we can measure gas-phase metallicities. For the first time, we show a discernible difference between the mass-metallicity relation, using individual galaxies, when dividing the sample by low (<10 M ⊙ yr-1) and high (>10 M ⊙ yr-1) SFRs. At fixed mass, low star-forming galaxies tend to have higher metallicity than high star-forming galaxies. Using a few basic assumptions, we further show that the gas masses and metallicities required to produce the fundamental mass-metallicity relation and its intrinsic scatter are consistent with cold-mode accretion predictions obtained from the OWLS hydrodynamical simulations. Our results from both simulations and observations are suggestive that cold-mode accretion is responsible for the fundamental mass-metallicity relation at z = 2 and it demonstrates the direct relationship between cosmological accretion and the fundamental properties of galaxies.

Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs.

PubMed

Towler, D A; Bennett, C D; Rodan, G A

1994-05-01

A detailed analysis of the transcriptional machinery responsible for osteoblast-specific gene expression should provide tools useful for understanding osteoblast commitment and differentiation. We have defined three cis-elements important for basal activity of the rat osteocalcin (OC) promoter, located at about -200 to -180, -170 to -138, and -121 to -64 relative to the transcription initiation site. A motif (TCTGATTGTGT) present in the region between -200 and -170 that binds a multisubunit CP1/NFY/CBF-like CAAT factor complex contributes significantly to high level basal activity and presumably functions as the CAAT box for the rat OC promoter. We show that the region -121 to 32 is sufficient to confer osteoblastic cell type specificity in transient transfection assays of cultured cell lines using luciferase as a reporter. The basal promoter is active in rodent osteoblastic cell lines, but not in rodent fibroblastic or muscle cell lines. Although the rat OC box (-100 to -74) contains a CAAT motif, we could not detect CP1-like CAAT factor binding to this region. In fact, we demonstrate that a Msx-1 (Hox 7.1) homeodomain binding motif (ACTAATTG; bottom strand) in the 3'-end of the rat OC box is necessary for high level activity of the rat OC basal promoter in osteoblastic cells. A nuclear factor that recognizes this motif appears to be present in osteoblastic ROS 17/2.8 cells, which produce OC, but not in fibroblastic ROS 25/1 cells, which fail to express OC. This ROS 17/2.8 nuclear factor also recognizes the A/T-rich DNA cognates of the homeodomain-containing POU family of transcription factors. Taken together, these data suggest that a ubiquitous CP1-like CAAT factor and a cell type-restricted homeodomain containing (Msx or POU family) transcription factor interact with the proximal rat OC promoter to direct appropriate basal OC transcription in osteoblastic cells.

Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial.

PubMed

Perfilyev, Alexander; Dahlman, Ingrid; Gillberg, Linn; Rosqvist, Fredrik; Iggman, David; Volkov, Petr; Nilsson, Emma; Risérus, Ulf; Ling, Charlotte

2017-04-01

Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) have different metabolic responses. Objective: We investigated whether the epigenome of human adipose tissue is affected differently by dietary fat composition and general overfeeding in a randomized trial. Design: We studied the effects of 7 wk of excessive SFA ( n = 17) or PUFA ( n = 14) intake (+750 kcal/d) on the DNA methylation of ∼450,000 sites in human subcutaneous adipose tissue. Both diets resulted in similar body weight increases. We also combined the data from the 2 groups to examine the overall effect of overfeeding on the DNA methylation in adipose tissue. Results: The DNA methylation of 4875 Cytosine-phosphate-guanine (CpG) sites was affected differently between the 2 diets. Furthermore, both the SFA and PUFA diets increased the mean degree of DNA methylation in adipose tissue, particularly in promoter regions. However, although the mean methylation was changed in 1797 genes [e.g., alpha-ketoglutarate dependent dioxygenase ( FTO ), interleukin 6 ( IL6 ), insulin receptor ( INSR ), neuronal growth regulator 1 ( NEGR1 ), and proopiomelanocortin ( POMC )] by PUFAs, only 125 genes [e.g., adiponectin, C1Q and collagen domain containing ( ADIPOQ )] were changed by SFA overfeeding. In addition, the SFA diet significantly altered the expression of 28 transcripts [e.g., acyl-CoA oxidase 1 ( ACOX1 ) and FAT atypical cadherin 1 ( FAT1 )], whereas the PUFA diet did not significantly affect gene expression. When the data from the 2 diet groups were combined, the mean methylation of 1444 genes, including fatty acid binding protein 1 ( FABP1 ), fatty acid binding protein 2 ( FABP2 ), melanocortin 2 receptor ( MC2R ), MC3R , PPARG coactivator 1 α ( PPARGC1A ), and tumor necrosis factor ( TNF ), was changed in adipose tissue by overfeeding. Moreover, the baseline DNA methylation of 12 CpG sites that was annotated to 9 genes [e.g., mitogen-activated protein kinase 7 ( MAPK7 ), melanin concentrating hormone receptor 1 ( MCHR1 ), and splicing factor SWAP homolog ( SFRS8 )] was associated with the degree of weight increase in response to extra energy intake. Conclusions: SFA overfeeding and PUFA overfeeding induce distinct epigenetic changes in human adipose tissue. In addition, we present data that suggest that baseline DNA methylation can predict weight increase in response to overfeeding in humans. This trial was registered at clinicaltrials.gov as NCT01427140. © 2017 American Society for Nutrition.

School Counselors' Role in Dating Violence Intervention

ERIC Educational Resources Information Center

Craigen, Laurie M.; Sikes, April; Healey, Amanda; Hays, Danica

2009-01-01

Dating violence among adolescents is a major public health concern. The purpose of this paper is to examine five factors of which school counselors must be aware in order to recognize, intervene, and report incidence of dating violence. These factors are (a) understanding the diverse definitions of dating violence, (b) recognizing dating violence…

Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening.

PubMed

Boyer, Kenneth M; Holfels, Ellen; Roizen, Nancy; Swisher, Charles; Mack, Douglas; Remington, Jack; Withers, Shawn; Meier, Paul; McLeod, Rima

2005-02-01

The purpose of this study was to determine whether demographic characteristics, history of exposure to recognized transmission vehicles, or illness that was compatible with acute toxoplasmosis during gestation identified most mothers of infants with congenital toxoplasmosis. Mothers of 131 infants and children who were referred to a national study of treatment for congenital toxoplasmosis were characterized demographically and questioned concerning exposure to recognized risk factors or illness. No broad demographic features identified populations that were at risk. Only 48% of mothers recognized epidemiologic risk factors (direct or indirect exposure to raw/undercooked meat or to cat excrement) or gestational illnesses that were compatible with acute acquired toxoplasmosis during pregnancy. Maternal risk factors or compatible illnesses were recognized in retrospect by fewer than one half of North American mothers of infants with toxoplasmosis. Educational programs might have prevented acquisition of Toxoplasma gondii by those mothers who had clear exposure risks. However, only systematic serologic screening of all pregnant women at prenatal visits or of all newborn infants at birth would prevent or detect a higher proportion of these congenital infections.

Factors associated with recognition and prioritization for falling, and the effect on fall incidence in community dwelling older adults.

PubMed

Jansen, Sofie; Schoe, Jolanda; van Rijn, Marjon; Abu-Hanna, Ameen; Moll van Charante, Eric P; van der Velde, Nathalie; de Rooij, Sophia E

2015-12-17

Recent trials have shown that multifactorial fall interventions vary in effectiveness, possibly due to lack of adherence to the interventions. The aim of this study was to examine what proportion of older adults recognize their falls risk and prioritize for fall-preventive care, and which factors are associated with this prioritization. Observational study within the intervention arm of a cluster randomized controlled trial (RCT) on the effect of preventive interventions for geriatric problems in older community-dwellers at risk of functional decline.  general practices in the Netherlands. Participants were community dwellers (70+) in whom falling was identified as a condition. A comprehensive geriatric assessment (CGA) was performed by a registered community care nurse. Participants were asked which of the identified conditions they recognized and prioritized for in a preventive care plan, and subsequent interventions were started. Multivariable logistic regression was performed to identify which factors were associated with this prioritization. Fall-incidence was measured during one-year follow-up. The RCT included 6668 participants, 3430 were in the intervention arm. Of those, 1209 were at risk of functional decline, of whom 936 underwent CGA. In 380 participants (41 %), falling was identified as a condition; 62 (16 %) recognized this and 37 (10 %) prioritized for it. Factors associated with prioritization for falls-prevention were: recurrent falls in the past year (OR 2.2 [95 % CI 1.1-4.4]), severe fear-of-falling (OR 2.7 [1.2-6.0]) and use of a walking aid (2.3 [1.1-5.0]). Sixty participants received a preventive intervention for falling; 29 had prioritized for falling. Incidence of falls was higher in the priority group than the non-priority group (67 % vs. 37 % respectively) during first six months of follow-up, but similar between groups after 12 months (40.7 % vs. 44.4 %). The proportion of community-dwellers at risk of falls that recognizes this risk and prioritizes for preventive care is small. Recurrent falls in the past year, severe fear-of-falling and use of a walking aid were associated with prioritization. Prioritization was associated with a greater fall-risk during first six months, which appeared to level out at one-year follow-up. These results could aid in the identification of community-dwellings likely to benefit from fall-preventive interventions. NTR2653 , 17 December 2010.

Recognizing, Determining, and Addressing Entrepreneurial Innovations by Superintendents of Emerging or Established Educational Service Agencies

ERIC Educational Resources Information Center

Arfstrom, Kari M.

2009-01-01

This dissertation describes how entrepreneurial superintendents of educational service agencies (ESAs) recognize, determine and address common and distinct innovative characteristics within emerging or established regional educational environments. Because internal and external factors assist in recognizing innovative practices, this study…

STAR FORMATION RELATIONS IN THE MILKY WAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vutisalchavakul, Nalin; Evans II, Neal J.; Heyer, Mark, E-mail: nje@astro.as.utexas.edu

2016-11-01

The relations between star formation and properties of molecular clouds (MCs) are studied based on a sample of star-forming regions in the Galactic Plane. Sources were selected by having radio recombination lines to provide identification of associated MCs and dense clumps. Radio continuum emission and mid-infrared emission were used to determine star formation rates (SFRs), while {sup 13}CO and submillimeter dust continuum emission were used to obtain the masses of molecular and dense gas, respectively. We test whether total molecular gas or dense gas provides the best predictor of SFR. We also test two specific theoretical models, one relying onmore » the molecular mass divided by the free-fall time, the other using the free-fall time divided by the crossing time. Neither is supported by the data. The data are also compared to those from nearby star-forming regions and extragalactic data. The star formation “efficiency,” defined as SFR divided by mass, spreads over a large range when the mass refers to molecular gas; the standard deviation of the log of the efficiency decreases by a factor of three when the mass of relatively dense molecular gas is used rather than the mass of all of the molecular gas.« less

Report on Understanding and Predicting Effects of Thermal Aging on Microstructure and Tensile Properties of Grade 91 Steel for Structural Components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Meimei; Natesan, K.; Chen, Weiying

This report provides an update on understanding and predicting the effects of long-term thermal aging on microstructure and tensile properties of G91 to corroborate the ASME Code rules in strength reduction due to elevated temperature service. The research is to support the design and long-term operation of G91 structural components in sodium-cooled fast reactors (SFRs). The report is a Level 2 deliverable in FY17 (M2AT-17AN1602017), under the Work Package AT-17AN160201, “SFR Materials Testing” performed by the Argonne National Laboratory (ANL), as part of the Advanced Reactor Technologies Program.

Infrared Color Selection of Massive Galaxies at z > 3

NASA Astrophysics Data System (ADS)

Wang, T.; Elbaz, D.; Schreiber, C.; Pannella, M.; Shu, X.; Willner, S. P.; Ashby, M. L. N.; Huang, J.-S.; Fontana, A.; Dekel, A.; Daddi, E.; Ferguson, H. C.; Dunlop, J.; Ciesla, L.; Koekemoer, A. M.; Giavalisco, M.; Boutsia, K.; Finkelstein, S.; Juneau, S.; Barro, G.; Koo, D. C.; Michałowski, M. J.; Orellana, G.; Lu, Y.; Castellano, M.; Bourne, N.; Buitrago, F.; Santini, P.; Faber, S. M.; Hathi, N.; Lucas, R. A.; Pérez-González, P. G.

2016-01-01

We introduce a new color selection technique to identify high-redshift, massive galaxies that are systematically missed by Lyman-break selection. The new selection is based on the H160 (H) and Infrared Array Camera (IRAC) 4.5 μm bands, specifically H-[4.5]\\gt 2.25 mag. These galaxies, called “HIEROs,” include two major populations that can be separated with an additional J - H color. The populations are massive and dusty star-forming galaxies at z\\gt 3 ({JH}-{blue}) and extremely dusty galaxies at z≲ 3 ({JH}-{red}). The 350 arcmin2 of the GOODS-North and GOODS-South fields with the deepest Hubble Space Telescope (HST)/Wide Field Camera 3 (WFC3) near-infrared and IRAC data contain as many as 285 HIEROs down to [4.5]\\lt 24 mag. Inclusion of the most extreme HIEROs, not even detected in the H band, makes this selection particularly complete for the identification of massive high-redshift galaxies. We focus here primarily on {JH}-{blue} (z\\gt 3) HIEROs, which have a median photometric redshift < z> ˜ 4.4 and stellar mass {M}*˜ {10}10.6 {M}⊙ and are much fainter in the rest-frame UV than similarly massive Lyman-break galaxies (LBGs). Their star formation rates (SFRs), derived from their stacked infrared spectral energy distributions (SEDs), reach ˜240 {M}⊙ yr-1, leading to a specific SFR, {{sSFR}}\\equiv {{SFR}}/{M}*˜ 4.2 Gyr-1, suggesting that the sSFRs for massive galaxies continue to grow at z\\gt 2 but at a lower growth rate than from z = 0 to z = 2. With a median half-light radius of 2 kpc, including ˜ 20% as compact as quiescent (QS) galaxies at similar redshifts, {JH}-{blue} HIEROs represent perfect star-forming progenitors of the most massive ({M}*≳ {10}11.2 {M}⊙ ) compact QS galaxies at z˜ 3 and have the right number density. HIEROs make up ˜ 60% of all galaxies with {M}*\\gt {10}10.5 {M}⊙ identified at z\\gt 3 from their photometric redshifts. This is five times more than LBGs with nearly no overlap between the two populations. While HIEROs make up 15%-25% of the total SFR density at z˜ 4-5, they completely dominate the SFR density taking place in {M}*\\gt {10}10.5 {M}⊙ galaxies, and HIEROs are therefore crucial to understanding the very early phase of massive galaxy formation.

A Wide Area Survey for High-Redshift Massive Galaxies. II. Near-Infrared Spectroscopy of BzK-Selected Massive Star-Forming Galaxies

NASA Astrophysics Data System (ADS)

Onodera, Masato; Arimoto, Nobuo; Daddi, Emanuele; Renzini, Alvio; Kong, Xu; Cimatti, Andrea; Broadhurst, Tom; Alexander, Dave M.

2010-05-01

Results are presented from near-infrared spectroscopic observations of a sample of BzK-selected, massive star-forming galaxies (sBzKs) at 1.5 < z < 2.3 that were obtained with OHS/CISCO at the Subaru telescope and with SINFONI at the Very Large Telescope. Among the 28 sBzKs observed, Hα emission was detected in 14 objects, and for 11 of them the [N II] λ6583 flux was also measured. Multiwavelength photometry was also used to derive stellar masses and extinction parameters, whereas Hα and [N II] emissions have allowed us to estimate star formation rates (SFRs), metallicities, ionization mechanisms, and dynamical masses. In order to enforce agreement between SFRs from Hα with those derived from rest-frame UV and mid-infrared, additional obscuration for the emission lines (that originate in H II regions) was required compared to the extinction derived from the slope of the UV continuum. We have also derived the stellar mass-metallicity relation, as well as the relation between stellar mass and specific SFR (SSFR), and compared them to the results in other studies. At a given stellar mass, the sBzKs appear to have been already enriched to metallicities close to those of local star-forming galaxies of similar mass. The sBzKs presented here tend to have higher metallicities compared to those of UV-selected galaxies, indicating that near-infrared selected galaxies tend to be a chemically more evolved population. The sBzKs show SSFRs that are systematically higher, by up to ~2 orders of magnitude, compared to those of local galaxies of the same mass. The empirical correlations between stellar mass and metallicity, and stellar mass and SSFR are then compared with those of evolutionary population synthesis models constructed either with the simple closed-box assumption, or within an infall scenario. Within the assumptions that are built-in such models, it appears that a short timescale for the star formation (sime100 Myr) and large initial gas mass appear to be required if one wants to reproduce both relations simultaneously. Based on data collected at the Subaru telescope, which is operated by the National Astronomical Observatory of Japan (S04A-081, S05A-098), and on observations collected at the European Southern Observatory, Paranal, Chile (075.A-0439).

ALMA deep field in SSA22: Blindly detected CO emitters and [C II] emitter candidates

NASA Astrophysics Data System (ADS)

Hayatsu, Natsuki H.; Matsuda, Yuichi; Umehata, Hideki; Yoshida, Naoki; Smail, Ian; Swinbank, A. Mark; Ivison, Rob; Kohno, Kotaro; Tamura, Yoichi; Kubo, Mariko; Iono, Daisuke; Hatsukade, Bunyo; Nakanishi, Kouichiro; Kawabe, Ryohei; Nagao, Tohru; Inoue, Akio K.; Takeuchi, Tsutomu T.; Lee, Minju; Ao, Yiping; Fujimoto, Seiji; Izumi, Takuma; Yamaguchi, Yuki; Ikarashi, Soh; Yamada, Toru

2017-06-01

We report the identification of four millimeter line-emitting galaxies with the Atacama Large Milli/submillimeter Array (ALMA) in SSA22 Field (ADF22). We analyze the ALMA 1.1-mm survey data, with an effective survey area of 5 arcmin2, frequency ranges of 253.1-256.8 and 269.1-272.8 GHz, angular resolution of 0{^''.}7 and rms noise of 0.8 mJy beam-1 at 36 km s-1 velocity resolution. We detect four line-emitter candidates with significance levels above 6σ. We identify one of the four sources as a CO(9-8) emitter at z = 3.1 in a member of the proto-cluster known in this field. Another line emitter with an optical counterpart is likely a CO(4-3) emitter at z = 0.7. The other two sources without any millimeter continuum or optical/near-infrared counterpart are likely to be [C II] emitter candidates at z = 6.0 and 6.5. The equivalent widths of the [C II] candidates are consistent with those of confirmed high-redshift [C II] emitters and candidates, and are a factor of 10 times larger than that of the CO(9-8) emitter detected in this search. The [C II] luminosity of the candidates are 4-7 × 108 L⊙. The star formation rates (SFRs) of these sources are estimated to be 10-20 M⊙ yr-1 if we adopt an empirical [C II] luminosity-SFR relation. One of them has a relatively low S/N ratio, but shows features characteristic of emission lines. Assuming that at least one of the two candidates is a [C II] emitter, we derive a lower limit of [C II]-based star formation rate density (SFRD) at z ˜ 6. The resulting value of >10-2 M⊙ yr-1 Mpc-3 is consistent with the dust-uncorrected UV-based SFRD. Future millimeter/submillimeter surveys can be used to detect a number of high-redshift line emitters, with which to study the star formation history in the early universe.

SRY, like HMG1, recognizes sharp angles in DNA.

PubMed Central

Ferrari, S; Harley, V R; Pontiggia, A; Goodfellow, P N; Lovell-Badge, R; Bianchi, M E

1992-01-01

HMG boxes are DNA binding domains present in chromatin proteins, general transcription factors for nucleolar and mitochondrial RNA polymerases, and gene- and tissue-specific transcriptional regulators. The HMG boxes of HMG1, an abundant component of chromatin, interact specifically with four-way junctions, DNA structures that are cross-shaped and contain angles of approximately 60 and 120 degrees between their arms. We show here also that the HMG box of SRY, the protein that determines the expression of male-specific genes in humans, recognizes four-way junction DNAs irrespective of their sequence. In addition, when SRY binds to linear duplex DNA containing its specific target AACAAAG, it produces a sharp bend. Therefore, the interaction between HMG boxes and DNA appears to be predominantly structure-specific. The production of the recognition of a kink in DNA can serve several distinct functions, such as the repair of DNA lesions, the folding of DNA segments with bound transcriptional factors into productive complexes or the wrapping of DNA in chromatin. Images PMID:1425584

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

PubMed Central

Batsuli, Glaivy; Deng, Wei; Healey, John F.; Parker, Ernest T.; Baldwin, W. Hunter; Cox, Courtney; Nguyen, Brenda; Kahle, Joerg; Königs, Christoph; Li, Renhao; Lollar, Pete

2016-01-01

Inhibitor formation in hemophilia A is the most feared treatment-related complication of factor VIII (fVIII) therapy. Most inhibitor patients with hemophilia A develop antibodies against the fVIII A2 and C2 domains. Recent evidence demonstrates that the C1 domain contributes to the inhibitor response. Inhibitory anti-C1 monoclonal antibodies (mAbs) have been identified that bind to putative phospholipid and von Willebrand factor (VWF) binding epitopes and block endocytosis of fVIII by antigen presenting cells. We now demonstrate by competitive enzyme-linked immunosorbent assay and hydrogen-deuterium exchange mass spectrometry that 7 of 9 anti-human C1 mAbs tested recognize an epitope distinct from the C1 phospholipid binding site. These mAbs, designated group A, display high binding affinities for fVIII, weakly inhibit fVIII procoagulant activity, poorly inhibit fVIII binding to phospholipid, and exhibit heterogeneity with respect to blocking fVIII binding to VWF. Another mAb, designated group B, inhibits fVIII procoagulant activity, fVIII binding to VWF and phospholipid, fVIIIa incorporation into the intrinsic Xase complex, thrombin generation in plasma, and fVIII uptake by dendritic cells. Group A and B epitopes are distinct from the epitope recognized by the canonical, human-derived inhibitory anti-C1 mAb, KM33, whose epitope overlaps both groups A and B. Antibodies recognizing group A and B epitopes are present in inhibitor plasmas from patients with hemophilia A. Additionally, group A and B mAbs increase fVIII clearance and are pathogenic in a hemophilia A mouse tail snip bleeding model. Group A anti-C1 mAbs represent the first identification of pathogenic, weakly inhibitory antibodies that increase fVIII clearance. PMID:27381905

Recognizing and managing type 2 diabetes mellitus in children: an algorithm for primary care providers.

PubMed

Sunni, Muna; Mays, Rita; Kaup, Tara; Nathan, Brandon

2011-08-01

During the last two decades, type 2 diabetes mellitus increasingly has been seen in children. Although still not as common as type 1 diabetes among children, it has become the leading form of diabetes among adolescents of certain ethnicities. It is imperative that primary care providers recognize the risk factors, perform appropriate screening tests, and initiate therapy for children who have type 2 diabetes or prediabetes. This article discusses the epidemiology and pathogenesis of the disease, complications, and treatments, and includes a concise, easy-to-follow algorithm to assist providers in diagnosing and treating young patients.

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT.

PubMed Central

Masuda, E S; Tokumitsu, H; Tsuboi, A; Shlomai, J; Hung, P; Arai, K; Arai, N

1993-01-01

Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor. We have previously shown that a fragment containing bp -95 to +27 of the mouse GM-CSF promoter can confer inducibility to reporter genes in the human Jurkat T-cell line. Here we use an in vitro transcription system to demonstrate that a cis-acting element (positions -54 to -40), referred to as CLE0, is a target for the induction signals. We observed induction with templates containing intact CLE0 but not with templates with deleted or mutated CLE0. We also observed that two distinct signals were required for the stimulation through CLE0, since only extracts from cells treated with both phorbol myristate acetate and A23187 supported optimal induction. Stimulation probably was mediated by CLE0-binding proteins because depletion of these proteins specifically reduced GM-CSF transcription. One of the binding factors possessed biochemical and immunological features identical to those of the transcription factor AP1. Another factor resembled the T-cell-specific factor NFAT. The characteristics of these two factors are consistent with their involvement in GM-CSF induction. The presence of CLE0-like elements in the promoters of interleukin-3 (IL-3), IL-4, IL-5, GM-CSF, and NFAT sites in the IL-2 promoter suggests that the factors we detected, or related factors that recognize these sites, may account for the coordinate induction of these genes during T-cell activation. Images PMID:8246960

Doing Business with China.

ERIC Educational Resources Information Center

Department of Commerce, Washington, DC. Industry and Trade Administration.

This publication provides background and practical information for those interested in doing business with China. The United States officially recognized the People's Republic of China (PRC) on January 1, 1979. Chinese leaders view international trade as an important factor in transforming China into a modern industrial state as well as an…

Impact of sleeper berth usage on commercial driver fatigue : task 1

DOT National Transportation Integrated Search

1999-11-01

Driver fatigue is recognized as a major factor in the safety of long-haul commercial driving. Sleeper berths are often provided on tractors to allow the driver to sleep and rest when not driving. However, the sleeper berth environment and/or the mann...

Hot Dust in Panchromatic SED Fitting: Identification of Active Galactic Nuclei and Improved Galaxy Properties

NASA Astrophysics Data System (ADS)

Leja, Joel; Johnson, Benjamin D.; Conroy, Charlie; van Dokkum, Pieter

2018-02-01

Forward modeling of the full galaxy SED is a powerful technique, providing self-consistent constraints on stellar ages, dust properties, and metallicities. However, the accuracy of these results is contingent on the accuracy of the model. One significant source of uncertainty is the contribution of obscured AGN, as they are relatively common and can produce substantial mid-IR (MIR) emission. Here we include emission from dusty AGN torii in the Prospector SED-fitting framework, and fit the UV–IR broadband photometry of 129 nearby galaxies. We find that 10% of the fitted galaxies host an AGN contributing >10% of the observed galaxy MIR luminosity. We demonstrate the necessity of this AGN component in the following ways. First, we compare observed spectral features to spectral features predicted from our model fit to the photometry. We find that the AGN component greatly improves predictions for observed Hα and Hβ luminosities, as well as mid-infrared Akari and Spitzer/IRS spectra. Second, we show that inclusion of the AGN component changes stellar ages and SFRs by up to a factor of 10, and dust attenuations by up to a factor of 2.5. Finally, we show that the strength of our model AGN component correlates with independent AGN indicators, suggesting that these galaxies truly host AGN. Notably, only 46% of the SED-detected AGN would be detected with a simple MIR color selection. Based on these results, we conclude that SED models which fit MIR data without AGN components are vulnerable to substantial bias in their derived parameters.

Superiority of reproductive histories to sperm counts in detecting infertility at a dibromochloropropane manufacturing plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levine, R.J.; Blunden, P.B.; DalCorso, R.D.

1983-08-01

Sperm count distributions among exposed and control groups at a dibromochloropropane (DBCP) manufacturing plant were remarkably similar. Yet reproductive histories from 60 exposed men obtained in conjunction with the semen analyses indicated that fertility had been reduced during exposure. Ratios of observed to expected births or standardized fertility ratios (SFRs) were computed for reproductive experience at parities of 1 or greater. The SFR for the period at risk from DBCP exposure (SFR . 0.63) was significantly lower than those derived from the entire not-at-risk period (SFR . 1.21) or the portion related to nonexposed employment at the plant preceding exposuremore » (SFR . 1.33). Significant reductions would have been evident at least 18 years prior to the year in which the histories were obtained. The effect on fertility seems to have been greatest during the initial period of DBCP production. Most fertility reduction occurred after 3.5 years of exposure. Fertility returned to normal following cessation of exposure (SFR . 1.18), although it appeared to remain subnormal for about two years. Wherever there is concern about the potential for adverse reproductive effects in the workplace, data suitable for fertility analyses should be collected during annual medical examinations.« less

Heterogeneous sodium fast reactor designed for transmuting minor actinide waste isotopes into plutonium fuel

NASA Astrophysics Data System (ADS)

Bays, Samuel Eugene

2008-10-01

In the past several years there has been a renewed interest in sodium fast reactor (SFR) technology for the purpose of destroying transuranic waste (TRU) produced by light water reactors (LWR). The utility of SFRs as waste burners is due to the fact that higher neutron energies allow all of the actinides, including the minor actinides (MA), to contribute to fission. It is well understood that many of the design issues of LWR spent nuclear fuel (SNF) disposal in a geologic repository are linked to MAs. Because the probability of fission for essentially all the "non-fissile" MAs is nearly zero at low neutron energies, these isotopes act as a neutron capture sink in most thermal reactor systems. Furthermore, because most of the isotopes produced by these capture reactions are also non-fissile, they too are neutron sinks in most thermal reactor systems. Conversely, with high neutron energies, the MAs can produce neutrons by fast fission. Additionally, capture reactions transmute the MAs into mostly plutonium isotopes, which can fission more readily at any energy. The transmutation of non-fissile into fissile atoms is the premise of the plutonium breeder reactor. In a breeder reactor, not only does the non-fissile "fertile" U-238 atom contribute fast fission neutrons, but also transmutes into fissile Pu-239. The fissile value of the plutonium produced by MA transmutation can only be realized in fast neutron spectra. This is due to the fact that the predominate isotope produced by MA transmutation, Pu-238, is itself not fissile. However, the Pu-238 fission cross section is significantly larger than the original transmutation parent, predominately: Np-237 and Am-241, in the fast energy range. Also, Pu-238's fission cross section and fission-to-capture ratio is almost as high as that of fissile Pu-239 in the fast neutron spectrum. It is also important to note that a neutron absorption in Pu-238, that does not cause fission, will instead produce fissile Pu-239. Given this fast fissile quality and also the fact that Pu-238 is transmuted from Np-237 and Am-241, these MAs are regarded as fertile material in the SFR design proposed by this dissertation. This dissertation demonstrates a SFR design which is dedicated to plutonium breeding by targeting Am-241 transmutation. This SFR design uses a moderated axial transmutation target that functions primarily as a pseudo-blanket fuel, which is reprocessed with the active driver fuel in an integrated recycling strategy. This work demonstrates the cost and feasibility advantages of plutonium breeding via MA transmutation by adopting reactor, reprocessing and fuel technologies previously demonstrated for traditional breeder reactors. The fuel cycle proposed seeks to find a harmony between the waste management advantages of transuranic burning SFRs and the resource sustainability of traditional plutonium breeder SFRs. As a result, the enhanced plutonium conversion from MAs decreases the burner SFR's fuel costs, by extracting more fissile value from the initial TRU purchased through SNF reprocessing.

Teaching in a Diverse Society.

ERIC Educational Resources Information Center

Grossman, Herbert

The goal of this text is to help educators recognize and reduce ethnic, socioeconomic, gender, contextual, and communicative disparities and inequalities in school. It is designed for preservice educators and attempts to help them understand the influence of diversity factors on the educational careers of their students. Chapter 1 describes the…

28 CFR 32.13 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... or stroke is a substantial factor in bringing it about. Engagement in a situation involving law... government) legally recognizes him to have been in such course at the time of such engagement (or, at a... include any engagement or participation described in the Act, at 42 U.S.C. 3796(k)(1). Excessive...

TPA can overcome the requirement for EIa and together act synergistically in stimulating expression of the adenovirus EIII promoter.

PubMed Central

Buckbinder, L; Miralles, V J; Reinberg, D

1989-01-01

We have examined the control of gene expression from the adenovirus early region III (Ad-EIII) promoter, which contains two previously defined elements, the AP1 and ATF sites. We found that the AP1 element is capable of mediating activation by the adenovirus immediate early (EIa) gene products. Consistent with studies demonstrating that the AP1 site mediates signal transduction in response to 12-O-tetradecanoylphorbol 13-acetate (TPA) we have shown that TPA can activate Ad-EIII expression and overcome the requirement for EIa. Together TPA and EIa elicited a synergistic response in expression from the Ad-EIII promoter during both transient expression assays and viral infections. This synergistic effect required the AP1 element. An EIII promoter construct, in which sequences upstream of the TATA box had been replaced with four AP1 sites, was responsive to TPA and EIa and in combination promoted the synergistic effect. The analysis of specific factors involved in transcription from the Ad-EIII indicated that proteins recognizing the ATF and AP1 sites were important in expression from this promoter in vitro. Purification of protein factors that specifically stimulated EIII expression resulted in the isolation of a set of factors of the AP1 family. Affinity purified AP1 recognized and activated transcription through both the AP1 and ATF elements. In addition, a protein fraction was identified with DNA binding activity specific for the ATF element. This fraction was dependent on the ATF site for transcriptional activity. Images PMID:2531661

Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family.

PubMed

Dai, Qi; Ren, Aiming; Westholm, Jakub O; Duan, Hong; Patel, Dinshaw J; Lai, Eric C

2015-01-01

Recently, the BEN (BANP, E5R, and NAC1) domain was recognized as a new class of conserved DNA-binding domain. The fly genome encodes three proteins that bear only a single BEN domain ("BEN-solo" factors); namely, Insensitive (Insv), Bsg25A (Elba1), and CG9883 (Elba2). Insv homodimers preferentially bind CCAATTGG palindromes throughout the genome to mediate transcriptional repression, whereas Bsg25A and Elba2 heterotrimerize with their obligate adaptor, Elba3 (i.e., the ELBA complex), to recognize a CCAATAAG motif in the Fab-7 insulator. While these data suggest distinct DNA-binding properties of BEN-solo proteins, we performed reporter assays that indicate that both Bsg25A and Elba2 can individually recognize Insv consensus sites efficiently. We confirmed this by solving the structure of Bsg25A complexed to the Insv site, which showed that key aspects of the BEN:DNA recognition strategy are similar between these proteins. We next show that both Insv and ELBA proteins are competent to mediate transcriptional repression via Insv consensus sequences but that the ELBA complex appears to be selective for the ELBA site. Reciprocally, genome-wide analysis reveals that Insv exhibits significant cobinding to class I insulator elements, indicating that it may also contribute to insulator function. Indeed, we observed abundant Insv binding within the Hox complexes with substantial overlaps with class I insulators, many of which bear Insv consensus sites. Moreover, Insv coimmunoprecipitates with the class I insulator factor CP190. Finally, we observed that Insv harbors exclusive activity among fly BEN-solo factors with respect to regulation of Notch-mediated cell fate choices in the peripheral nervous system. This in vivo activity is recapitulated by BEND6, a mammalian BEN-solo factor that conserves the Notch corepressor function of Insv but not its capacity to bind Insv consensus sites. Altogether, our data define an array of common and distinct biochemical and functional properties of this new family of transcription factors. © 2015 Dai et al.; Published by Cold Spring Harbor Laboratory Press.

Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family

PubMed Central

Dai, Qi; Ren, Aiming; Westholm, Jakub O.; Duan, Hong; Patel, Dinshaw J.

2015-01-01

Recently, the BEN (BANP, E5R, and NAC1) domain was recognized as a new class of conserved DNA-binding domain. The fly genome encodes three proteins that bear only a single BEN domain (“BEN-solo” factors); namely, Insensitive (Insv), Bsg25A (Elba1), and CG9883 (Elba2). Insv homodimers preferentially bind CCAATTGG palindromes throughout the genome to mediate transcriptional repression, whereas Bsg25A and Elba2 heterotrimerize with their obligate adaptor, Elba3 (i.e., the ELBA complex), to recognize a CCAATAAG motif in the Fab-7 insulator. While these data suggest distinct DNA-binding properties of BEN-solo proteins, we performed reporter assays that indicate that both Bsg25A and Elba2 can individually recognize Insv consensus sites efficiently. We confirmed this by solving the structure of Bsg25A complexed to the Insv site, which showed that key aspects of the BEN:DNA recognition strategy are similar between these proteins. We next show that both Insv and ELBA proteins are competent to mediate transcriptional repression via Insv consensus sequences but that the ELBA complex appears to be selective for the ELBA site. Reciprocally, genome-wide analysis reveals that Insv exhibits significant cobinding to class I insulator elements, indicating that it may also contribute to insulator function. Indeed, we observed abundant Insv binding within the Hox complexes with substantial overlaps with class I insulators, many of which bear Insv consensus sites. Moreover, Insv coimmunoprecipitates with the class I insulator factor CP190. Finally, we observed that Insv harbors exclusive activity among fly BEN-solo factors with respect to regulation of Notch-mediated cell fate choices in the peripheral nervous system. This in vivo activity is recapitulated by BEND6, a mammalian BEN-solo factor that conserves the Notch corepressor function of Insv but not its capacity to bind Insv consensus sites. Altogether, our data define an array of common and distinct biochemical and functional properties of this new family of transcription factors. PMID:25561495

GROUND-BASED Paα NARROW-BAND IMAGING OF LOCAL LUMINOUS INFRARED GALAXIES. I. STAR FORMATION RATES AND SURFACE DENSITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tateuchi, Ken; Konishi, Masahiro; Motohara, Kentaro

2015-03-15

Luminous infrared galaxies (LIRGs) are enshrouded by a large amount of dust produced by their active star formation, and it is difficult to measure their activity in optical wavelengths. We have carried out Paα narrow-band imaging observations of 38 nearby star forming galaxies including 33 LIRGs listed in the IRAS Revised Bright Galaxy Sample catalog with the Atacama Near InfraRed camera on the University of Tokyo Atacama Observatory (TAO) 1.0 m telescope (miniTAO). Star formation rates (SFRs) estimated from the Paα fluxes, corrected for dust extinction using the Balmer decrement method (typically A{sub V} ∼ 4.3 mag), show a good correlation with thosemore » from the bolometric infrared luminosity of the IRAS data within a scatter of 0.27 dex. This suggests that the correction of dust extinction for the Paα flux is sufficient in our sample. We measure the physical sizes and surface densities of infrared luminosities (Σ{sub L(IR)}) and the SFR (Σ{sub SFR}) of star forming regions for individual galaxies, and we find that most of the galaxies follow a sequence of local ultra-luminous or luminous infrared galaxies (U/LIRGs) on the L(IR)-Σ{sub L(IR)} and SFR-Σ{sub SFR} plane. We confirm that a transition of the sequence from normal galaxies to U/LIRGs is seen at L(IR) = 8 × 10{sup 10} L {sub ☉}. Also, we find that there is a large scatter in physical size, different from normal galaxies or ULIRGs. Considering the fact that most U/LIRGs are merging or interacting galaxies, this scatter may be caused by strong external factors or differences in their merging stages.« less

Transcription factor ThWRKY4 binds to a novel WLS motif and a RAV1A element in addition to the W-box to regulate gene expression.

PubMed

Xu, Hongyun; Shi, Xinxin; Wang, Zhibo; Gao, Caiqiu; Wang, Chao; Wang, Yucheng

2017-08-01

WRKY transcription factors play important roles in many biological processes, and mainly bind to the W-box element to regulate gene expression. Previously, we characterized a WRKY gene from Tamarix hispida, ThWRKY4, in response to abiotic stress, and showed that it bound to the W-box motif. However, whether ThWRKY4 could bind to other motifs remains unknown. In this study, we employed a Transcription Factor-Centered Yeast one Hybrid (TF-Centered Y1H) screen to study the motifs recognized by ThWRKY4. In addition to the W-box core cis-element (termed W-box), we identified that ThWRKY4 could bind to two other motifs: the RAV1A element (CAACA) and a novel motif with sequence of GTCTA (W-box like sequence, WLS). The distributions of these motifs were screened in the promoter regions of genes regulated by some WRKYs. The results showed that the W-box, RAV1A, and WLS motifs were all present in high numbers, suggesting that they play key roles in gene expression mediated by WRKYs. Furthermore, five WRKY proteins from different WRKY subfamilies in Arabidopsis thaliana were selected and confirmed to bind to the RAV1A and WLS motifs, indicating that they are recognized commonly by WRKYs. These findings will help to further reveal the functions of WRKY proteins. Copyright © 2017 Elsevier B.V. All rights reserved.

Heterogeneity of Metastatic Melanoma:  Correlation of MITF With Its Transcriptional Targets MLSN1, PEDF, HMB-45, and MART-1.

PubMed

Zand, Sarvenaz; Buzney, Elizabeth; Duncan, Lyn M; Dadras, Soheil S

2016-09-01

Histologic and molecular heterogeneity is well recognized in malignant melanoma; however, the diversity of expression of new and classic melanoma markers has not been correlated in serial sections of metastases. We examined and correlated the expression of microphthalmia transcription factor (MITF) with its transcriptional targets, including melastatin (MLSN1/TRPM1), pigment epithelium-derived factor (SERPINF1/PEDF), SILV/PMEL17/GP100 (human melanoma black 45 [HMB-45]), and melanoma antigen recognized by T cells 1 (MART-1)/MLANA, in 13 melanoma metastases in lymph nodes of 13 patients. The expression levels and patterns of marker expression were recorded by a semiquantitative, 4-point ordinal reactivity method. Our results showed a consistently robust and diffuse expression of MITF protein in 12 (92%) of 13 metastatic tumors compared with variable expression of MLSN1 (46%) messenger RNA or PEDF (75%), HMB-45 (54%), and MART-1 (46%) proteins. Overall, in melanoma lymph node metastases, MITF protein expression was not tightly correlated with its gene targets. Moreover, the immunoreactivity for MITF, compared with MART-1 and HMB-45, was retained, supporting immunohistochemical detection of MITF as a more sensitive method of detecting metastatic melanoma. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

How autophagy eats large mitochondria: Autophagosome formation coupled with mitochondrial fragmentation.

PubMed

Yamashita, Shun-Ichi; Kanki, Tomotake

2017-05-04

Mitochondrial autophagy (mitophagy) is thought to be a multi-step pathway wherein mitochondria are first divided into small fragments, which are subsequently recognized by the phagophore. DNM1L (dynamin 1 like) plays a pivotal role in mitochondrial division; however, its role in mitophagy remains controversial. In our recent study, we examined the contribution of DNM1L to mitophagy and showed that mitophagy and mitochondrial division occur even in DNM1L-defective cells. Furthermore, time-lapse imaging of mitophagy showed that DNM1L-independent mitochondrial division occurs concomitantly with autophagosome formation. Upstream factors of autophagosome formation, i.e., RB1CC1/FIP200, ATG14, and WIPIs, are required for mitochondrial division, whereas ATG5 and ATG3 are dispensable. These results indicate that a portion of the tubular mitochondria is first recognized and then divided into small fragments by a phagophore-mediated event, independently of DNM1L. This autophagic process suggests that autophagy has the potential to degrade substrates larger than autophagosomes.

ARE LARGE, COMETARY-SHAPED PROPLYDS REALLY (FREE-FLOATING) EVAPORATING GAS GLOBULES?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sahai, R.; Guesten, R.; Morris, M. R., E-mail: raghvendra.sahai@jpl.nasa.gov

2012-12-20

We report the detection of strong and compact molecular line emission (in the CO J = 3-2, 4-3, 6-5, 7-6, {sup 13}CO J = 3-2, HCN, and HCO{sup +} J = 4-3 transitions) from a cometary-shaped object (Carina-frEGG1) in the Carina star-forming region (SFR) previously classified as a photoevaporating protoplanetary disk (proplyd). We derive a molecular mass of 0.35 M{sub Sun} for Carina-frEGG1, which shows that it is not a proplyd, but belongs to a class of free-floating evaporating gas globules (frEGGs) recently found in the Cygnus SFR by Sahai et al. Archival adaptive optics near-IR (Ks) images show amore » central hourglass-shaped nebula. The derived source luminosity (about 8-18 L{sub Sun }), the hourglass morphology, and the presence of collimated jets seen in Hubble Space Telescope images imply the presence of a jet-driving, young, low-mass star deeply embedded in the dust inside Carina-frEGG1. Our results suggest that the true nature of many or most such cometary-shaped objects seen in massive SFRs and previously labeled as proplyds has been misunderstood, and that these are really frEGGs.« less

COLD-MODE ACCRETION: DRIVING THE FUNDAMENTAL MASS–METALLICITY RELATION AT z ∼ 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kacprzak, Glenn G.; Glazebrook, Karl; Nanayakkara, Themiya

2016-07-20

We investigate the star formation rate (SFR) dependence on the stellar mass and gas-phase metallicity relation at z = 2 with MOSFIRE/Keck as part of the ZFIRE survey. We have identified 117 galaxies (1.98 ≤ z ≤ 2.56), with 8.9 ≤ log( M / M {sub ⊙}) ≤ 11.0, for which we can measure gas-phase metallicities. For the first time, we show a discernible difference between the mass–metallicity relation, using individual galaxies, when dividing the sample by low (<10 M {sub ⊙} yr{sup −1}) and high (>10 M {sub ⊙} yr{sup −1}) SFRs. At fixed mass, low star-forming galaxies tendmore » to have higher metallicity than high star-forming galaxies. Using a few basic assumptions, we further show that the gas masses and metallicities required to produce the fundamental mass–metallicity relation and its intrinsic scatter are consistent with cold-mode accretion predictions obtained from the OWLS hydrodynamical simulations. Our results from both simulations and observations are suggestive that cold-mode accretion is responsible for the fundamental mass–metallicity relation at z = 2 and it demonstrates the direct relationship between cosmological accretion and the fundamental properties of galaxies.« less

THE HOST GALAXY PROPERTIES OF VARIABILITY SELECTED AGN IN THE PAN-STARRS1 MEDIUM DEEP SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heinis, S.; Gezari, S.; Kumar, S.

2016-07-20

We study the properties of 975 active galactic nuclei (AGNs) selected by variability in the Pan-STARRS1 Medium deep Survey. Using complementary multi-wavelength data from the ultraviolet to the far-infrared, we use spectral energy distribution fitting to determine the AGN and host properties at z < 1 and compare to a well-matched control sample. We confirm the trend previously observed: that the variability amplitude decreases with AGN luminosity, but we also observe that the slope of this relation steepens with wavelength, resulting in a “redder when brighter” trend at low luminosities. Our results show that AGNs are hosted by more massivemore » hosts than control sample galaxies, while the rest frame dust-corrected NUV r color distribution of AGN hosts is similar to control galaxies. We find a positive correlation between the AGN luminosity and star formation rate (SFR), independent of redshift. AGN hosts populate the entire range of SFRs within and outside of the Main Sequence of star-forming galaxies. Comparing the distribution of AGN hosts and control galaxies, we show that AGN hosts are less likely to be hosted by quiescent galaxies and more likely to be hosted by Main Sequence or starburst galaxies.« less

Galaxy and Mass Assembly (GAMA): galaxies at the faint end of the Hα luminosity function

NASA Astrophysics Data System (ADS)

Brough, S.; Hopkins, A. M.; Sharp, R. G.; Gunawardhana, M.; Wijesinghe, D.; Robotham, A. S. G.; Driver, S. P.; Baldry, I. K.; Bamford, S. P.; Liske, J.; Loveday, J.; Norberg, P.; Peacock, J. A.; Bland-Hawthorn, J.; Brown, M. J. I.; Cameron, E.; Croom, S. M.; Frenk, C. S.; Foster, C.; Hill, D. T.; Jones, D. H.; Kelvin, L. S.; Kuijken, K.; Nichol, R. C.; Parkinson, H. R.; Pimbblet, K.; Popescu, C. C.; Prescott, M.; Sutherland, W. J.; Taylor, E.; Thomas, D.; Tuffs, R. J.; van Kampen, E.

2011-05-01

We present an analysis of the properties of the lowest Hα-luminosity galaxies (LHα≤ 4 × 1032 W; SFR < 0.02 M⊙ yr-1, with SFR denoting the star formation rate) in the Galaxy And Mass Assembly survey. These galaxies make up the rise above a Schechter function in the number density of systems seen at the faint end of the Hα luminosity function. Above our flux limit, we find that these galaxies are principally composed of intrinsically low stellar mass systems (median stellar mass = 2.5 × 108 M⊙) with only 5/90 having stellar masses M > 1010 M⊙. The low-SFR systems are found to exist predominantly in the lowest-density environments (median density ˜0.02 galaxy Mpc-2) with none in environments more dense than ˜1.5 galaxy Mpc-2. Their current specific SFRs (SSFRs; -8.5 < log [SSFR (yr -1)] < -12) are consistent with their having had a variety of star formation histories. The low-density environments of these galaxies demonstrate that such low-mass, star-forming systems can only remain as low mass and form stars if they reside sufficiently far from other galaxies to avoid being accreted, dispersed through tidal effects or having their gas reservoirs rendered ineffective through external processes.

Atomic hydrogen bridge fueling NGC 4418 with gas from VV 655

NASA Astrophysics Data System (ADS)

Varenius, E.; Costagliola, F.; Klöckner, H.-R.; Aalto, S.; Spoon, H.; Martí-Vidal, I.; Conway, J. E.; Privon, G. C.; König, S.

2017-11-01

Context. The galaxy NGC 4418 harbours a compact (<20 pc) core with a very high bolometric luminosity ( 1011L⊙). As most of the galaxy energy output comes from this small region, it is of interest to determine what fuels this intense activity. An interaction with the nearby blue irregular galaxy VV 655 has been proposed, where gas acquired by NGC 4418 could trigger intense star formation and/or black hole accretion in the centre. Aims: We aim to constrain the interaction hypothesis by studying neutral hydrogen structures that could reveal tails and debris connecting NGC 4418 to the nearby galaxy VV 655. Methods: We present observations at 1.4 GHz with the Very Large Array (VLA) of the radio continuum as well as emission and absorption from atomic hydrogen. Gaussian distributions are fitted to observed HI emission and absorption spectra. We estimate the star formation rates (SFRs) of NGC 4418 and VV 655 from the 1.4 GHz radio emission and compare them with estimates from archival 70 μm Herschel observations. Results: An atomic HI bridge is seen in emission, connecting NGC 4418 to the nearby galaxy VV 655. An HI tail is also seen extending south-west from VV 655. While NGC 4418 is bright in continuum emission and seen in HI absorption, VV 655 is barely detected in the continuum, but shows bright HI emission (MHI 109 M⊙). We estimate SFRs from the 1.4 GHz continuum of 3.2 M⊙ yr-1 and 0.13 M⊙ yr-1 for NGC 4418 and VV 655, respectively. Systemic HI velocities of 2202 ± 20 km s-1 (emission) and 2105.4 ± 10 km s-1 (absorption) are measured for VV 655 and NGC 4418, respectively. Redshifted HI absorption is seen (vc = 2194.0 ± 4.4 km s-1) towards NGC 4418, suggesting gas infall. North-west of NGC 4418, we detect HI in emission, blueshifted (vc = 2061.9 ± 5.1 km s-1) with respect to NGC 4418, consistent with an outflow perpendicular to the galaxy disk. We derive a deprojected outflow speed of 178 km s-1, which, assuming a simple cylindrical model, gives an order-of-magnitude estimate of the HI mass outflow rate of 2.5 M⊙ yr-1. Conclusions: The morphology and velocity structure seen in HI is consistent with an interaction scenario where gas was transferred from VV 655 to NGC 4418. We argue that the galaxies have passed each other once, about 190 Myr ago, and that this interaction has caused the tidal HI bridge and HI tail seen today. Some gas is falling towards NGC 4418, and may fuel the activity in the centre. We interpret blueshifted HI-emission north-west of NGC 4418 as a continuation of the outflow previously reported on smaller scales, powered by star formation and/or black hole accretion in the centre. The movie associated to Fig. 4 is available at http://www.aanda.orgThe radio continuum image and the spectral cube presented in Fig. 1 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/607/A43

Star Formation Rates of dS galaxies

NASA Astrophysics Data System (ADS)

Hidalgo-Gámez, A. M.; Vega-Acevedo, I.; Magaña-Serrano, M. A.

2014-10-01

The Star Formation Rate of a sample of nine dwarf spiral galaxies and ten late-type Sm is determined from the Hα luminosity. The main interest was to check if these two kind of late-type galaxies have similar SFR or not. The images were acquired at the 1.5m telescope of the SPM-OAN and they were reduced with the software MIDAS. The values of the SFR are very similar for both type of galaxies and also similar to other Sm galaxies. The main result is that the dwarf spiral galaxies are more efficient when forming stars than the Sm galaxies because the SFR per are are lower for the latter with the same gas density than for dwarf spirals. However, the SFRs are larger in the Sm galaxies. In addition, the SFR per area were compared with global properties of the galaxies. There is only a relationship between the SFR and the surface brightness as well as with the absolute blue magnitude, but no relationship with the optical radius. A larger sample is needed in order to obtain a more conclusive answer.

Gamma-Ray Bursts: Lighting Up the High-Redshift Universe

NASA Astrophysics Data System (ADS)

Toy, Vicki Louise

Gamma-ray bursts (GRBs) are the most luminous events in the Universe with Egamma,iso ˜ 1048-54 erg. Leading models hypothesize that GRBs are created from inter- nal collisions within collimated and ultrarelativistic jets. The jets then shock-heat the surrounding material (e.g. interstellar medium) to create GRB afterglows. These afterglows are extremely useful probes of the Universe because long GRBs are (1) bright events that can be used as backlights for absorption studies, (2) able to probe at all redshifts massive stars exist, and (3) transient events that allow us to follow- up on the host galaxies at late times. In this thesis we study the environments of GRBs. We first explore the relationship between GRB and supernova (SN) using a nearby GRB-SN (GRB 130702A/SN 2013dx) at z = 0.145. There are only nine other GRB-SNe that were close enough to have extensive spectroscopic and photometric follow-up of the SN at late times. We create a quasi-bolometic light curve of SN 2013dx and fit an analytical equation to the quasi-bolometric light curve combined with measurements of the photospheric velocity to determine SN parameters: mass of 56Ni, kinetic energy, and ejecta mass. We examine the relationship between SN parameters and E gamma,iso for the 10 well-studied GRB-SNe, but find no correlations despite numerical simulation predictions that the mass of 56Ni should correlate with the degree of asymmetry. We then move to larger distance scales and use GRB afterglows as bright back- lights to study distant galaxies. We examine the galactic environments of Damped Lyman-alpha systems (DLAs; NHI ≥ 1020.3 cm-2 ) identified with GRB afterglows at z ˜ 2 - 6. We use late-time photometry after the GRB afterglow has faded to determine star formation rates (SFRs) from rest-frame ultraviolet measurements or spectral energy distribution (SED) models from multiband photometry. We com- pare our sample's SFRs to a sample of quasars (QSOs) DLA host galaxies. Despite the overlapping NHI and redshift ranges, our GRB-DLA galaxies have much larger SFRs than the QSO-DLA host galaxy sample; this may suggest that the QSO-DLA and GRB-DLA galaxy populations are different. We also compare star formation efficiencies to the local Universe and simulations at z = 3. A large portion of this thesis has focused on the development of a new ground- based GRB afterglow follow-up instrument, the Rapid infrared IMAger-Spectrometer (RIMAS), that will target high-redshift GRB afterglows to study early galaxy envi- ronments. RIMAS covers 0.97-2.37 mum and can simultaneously observe two band-passes in any observing mode: photometry, low-resolution spectroscopy (R ˜ 30), or high-resolution spectroscopy (R ˜ 4000). In particular, this thesis focuses on RIMAS's three detectors: two science grade Teledyne HgCdTe Astronomy Wide Area Infrared Imager with 2K x 2K, Reference Pixels and Guide Mode (H2RG) and a slit-viewer Spitzer Legacy Indium-Antimonide (InSb) array. We describe the detector hardware and characterization in detail and discuss general infrared detector troubleshooting methods at both cryogenic and room temperatures. Several software packages have been developed for RIMAS throughout this thesis work. We introduce RIMAS's quick reduction pipeline that takes raw images from a single acquisition and returns a single result frame. We then present a generalized data reduction pipeline that we have tested on two currently operational photometers. We also describe our detailed and realistic RIMAS throughput models for all three observing modes as well as our online observer calculators with these throughput models. All of our data products are open source and are publicly available on Github repositories with detailed documentation.

76 FR 33419 - Nationally Recognized Statistical Rating Organizations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... documentation of the internal control structure) or should the factors focus on the design (i.e., establishment... related to implementing them. a. Controls reasonably designed to ensure that a newly developed methodology... U.S.C. 78o-7(r)(1)(A). b. Controls reasonably designed to ensure that a newly developed methodology...

Bacillus thuringiensis Resistance Influences European Corn Borer (Lepidoptera: Crambidae) Larval Behavior after Exposure to Cry1Ab

USDA-ARS?s Scientific Manuscript database

The behavior of target pests has been recognized as an important factor to appropriately define resistance management plans for Bacillus thuringiensis (Bt) crops. However, most data available do not include the possible impact resistance alleles may have on the behavior of pest larvae or adults. To ...

Childhood Disability in the Family: Recognizing the Added Handicap. Monograph Number Fourteen.

ERIC Educational Resources Information Center

Zucman, Elizabeth

The author reviews research pertaining to parent behavior in relation to child development, repercussions of disability on family life, and techniques for helping parents of disabled children. Section 1 considers theoretical bases of parenting and normal development; biological, psychological, and social factors in the genesis of handicaps; parent…

A search for Hα emission in high-metallicity damped Lyman α systems at z ˜ 2.4

NASA Astrophysics Data System (ADS)

Wang, Wei-Hao; Kanekar, Nissim; Prochaska, J. Xavier

2015-04-01

We report on a sensitive search for redshifted Hα line-emission from three high-metallicity damped Lyα absorbers (DLAs) at z ≈ 2.4 with the Near-infrared Integral Field Spectrometer (NIFS) on the Gemini-North telescope, assisted by the ALTtitude conjugate Adaptive optics for the InfraRed (ALTAIR) system with a laser guide star. Within the NIFS field-of-view, ≈3.22 arcsec × 2.92 arcsec corresponding to ≈25 kpc × 23 kpc at z = 2.4, we detect no statistically significant line-emission at the expected redshifted Hα wavelengths. The measured root-mean-square noise fluctuations in 0.4 arcsec apertures are 1-3 × 10-18 erg s-1 cm-2. Our analysis of simulated, compact, line-emitting sources yields stringent limits on the star formation rates (SFRs) of the three DLAs, <2.2 M⊙ yr-1 (3σ) for two absorbers, and <11 M⊙ yr-1 (3σ) for the third, at all impact parameters within ≈12.5 kpc to the quasar sightline at the DLA redshift. For the third absorber, the SFR limit is <4.4 M⊙ yr-1 for locations away from the quasar sightline. These results demonstrate the potential of adaptive optics-assisted, integral field unit searches for galaxies associated with high-z DLAs.

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

PubMed

Nie, Jianyun; Xu, Chao; Jin, Jing; Aka, Juliette A; Tempel, Wolfram; Nguyen, Vivian; You, Linya; Weist, Ryan; Min, Jinrong; Pawson, Tony; Yang, Xiang-Jiao

2015-04-07

Peptide motifs are often used for protein-protein interactions. We have recently demonstrated that ankyrin repeats of ANKRA2 and the paralogous bare lymphocyte syndrome transcription factor RFXANK recognize PxLPxL/I motifs shared by megalin, three histone deacetylases, and RFX5. We show here that that CCDC8 is a major partner of ANKRA2 but not RFXANK in cells. The CCDC8 gene is mutated in 3M syndrome, a short-stature disorder with additional facial and skeletal abnormalities. Two other genes mutated in this syndrome encode CUL7 and OBSL1. While CUL7 is a ubiquitin ligase and OBSL1 associates with the cytoskeleton, little is known about CCDC8. Binding and structural analyses reveal that the ankyrin repeats of ANKRA2 recognize a PxLPxL motif at the C-terminal region of CCDC8. The N-terminal part interacts with OBSL1 to form a CUL7 ligase complex. These results link ANKRA2 unexpectedly to 3M syndrome and suggest novel regulatory mechanisms for histone deacetylases and RFX7. Copyright © 2015 Elsevier Ltd. All rights reserved.

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yong; Yang, Yuting; van Overbeek, Megan

2008-05-01

Mammalian telomeres are protected by a six-protein complex: shelterin. Shelterin contains two closely related proteins (TRF1 and TRF2), which recruit various proteins to telomeres. We dissect the interactions of TRF1 and TRF2 with their shared binding partner (TIN2) and other shelterin accessory factors. TRF1 recognizes TIN2 using a conserved molecular surface in its TRF homology (TRFH) domain. However, this same surface does not act as a TIN2 binding site in TRF2, and TIN2 binding to TRF2 is mediated by a region outside the TRFH domain. Instead, the TRFH docking site of TRF2 binds a shelterin accessory factor (Apollo), which doesmore » not interact with the TRFH domain of TRF1. Conversely, the TRFH domain of TRF1, but not of TRF2, interacts with another shelterin-associated factor: PinX1.« less

Evaluation of speech recognizers for use in advanced combat helicopter crew station research and development

NASA Technical Reports Server (NTRS)

Simpson, Carol A.

1990-01-01

The U.S. Army Crew Station Research and Development Facility uses vintage 1984 speech recognizers. An evaluation was performed of newer off-the-shelf speech recognition devices to determine whether newer technology performance and capabilities are substantially better than that of the Army's current speech recognizers. The Phonetic Discrimination (PD-100) Test was used to compare recognizer performance in two ambient noise conditions: quiet office and helicopter noise. Test tokens were spoken by males and females and in isolated-word and connected-work mode. Better overall recognition accuracy was obtained from the newer recognizers. Recognizer capabilities needed to support the development of human factors design requirements for speech command systems in advanced combat helicopters are listed.

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration.

PubMed

Spielman, Lindsay J; Little, Jonathan P; Klegeris, Andis

2014-08-15

Obesity is a growing epidemic that contributes to several brain disorders including Alzheimer's, Parkinson's, and Huntington's diseases. Obesity could promote these diseases through several different mechanisms. Here we review evidence supporting the involvement of two recently recognized factors linking obesity with neurodegeneration: the induction of pro-inflammatory cytokines and onset of insulin and insulin-like growth factor 1 (IGF-1) resistance. Excess peripheral pro-inflammatory mediators, some of which can cross the blood brain barrier, may trigger neuroinflammation, which subsequently exacerbates neurodegeneration. Insulin and IGF-1 resistance leads to weakening of neuroprotective signaling by these molecules and can contribute to onset of neurodegenerative diseases. Copyright © 2014 Elsevier B.V. All rights reserved.

THE STAR FORMATION HISTORIES OF z {approx} 2 DUST-OBSCURED GALAXIES AND SUBMILLIMETER-SELECTED GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bussmann, R. S.; Dey, Arjun; Jannuzi, B. T.

The Spitzer Space Telescope has identified a population of ultraluminous infrared galaxies (ULIRGs) at z {approx} 2 that may play an important role in the evolution of massive galaxies. We measure the stellar masses (M{sub *}) of two populations of Spitzer-selected ULIRGs that have extremely red R - [24] colors (dust-obscured galaxies, or DOGs) and compare our results with submillimeter-selected galaxies (SMGs). One set of 39 DOGs has a local maximum in their mid-infrared (mid-IR) spectral energy distribution (SED) at rest frame 1.6 {mu}m associated with stellar emission ({sup b}ump DOGs{sup )}, while the other set of 51 DOGs havemore » power-law mid-IR SEDs that are typical of obscured active galactic nuclei ({sup p}ower-law DOGs{sup )}. We measure M{sub *} by applying Charlot and Bruzual stellar population synthesis models to broadband photometry in the rest-frame ultraviolet, optical, and near-infrared of each of these populations. Assuming a simple stellar population and a Chabrier initial mass function, we find that power-law DOGs and bump DOGs are on average a factor of 2 and 1.5 more massive than SMGs, respectively (median and inter-quartile M{sub *} values for SMGs, bump DOGs, and power-law DOGs are log(M{sub *}/M{sub Sun }) = 10.42{sup +0.42}{sub -0.36}, 10.62{sup +0.36}{sub -0.32}, and 10.71{sup +0.40}{sub -0.34}, respectively). More realistic star formation histories drawn from two competing theories for the nature of ULIRGs at z {approx} 2 (major merger versus smooth accretion) can increase these mass estimates by up to 0.5 dex. A comparison of our stellar masses with the instantaneous star formation rate (SFR) in these z {approx} 2 ULIRGs provides a preliminary indication supporting high SFRs for a given M{sub *}, a situation that arises more naturally in major mergers than in smooth accretion-powered systems.« less

A non-invasive multiproxy approach to recognize Holocene paleocoastal environmental signals in Sri Lanka.

NASA Astrophysics Data System (ADS)

Ranasinghe, P. N.; Ortiz, J. D.; Siriwardana, C.

2009-05-01

Coastal lagoons are archives of paleocoastal environmental signatures. Lagoonal cores are extensively used to recognize paleo-sea level changes, plaeoclimatic changes, paleo-tsunami and storm deposits. Grain size, microfossil assemblages and organic carbon content are some of the common proxies used in such paleoenvironmental studies. This study attempts to use petrophysical methods to measure the physical properties of lagoonal cores to recognize paleoenvironmental signatures. Three sediment cores, each five meters in length, were collected in a 1 km long transect from a siliciclastic coastal lagoon at Kirinda, Sri Lanka. This south-eastern lagoon is highly susceptible to tsunamis and coastal flood events; The 2004 Asian tsunami generated 7-8 m waves in the area. Evidence for Holocene sea level changes are also preserved in nearby areas. Particle size, magnetic susceptibility and visible color reflectance were measured in the three cores at 1 cm resolution. Principal component analysis (PCA) was carried out with grain size (Q-mode) and reflectance data (R-mode). Log records and depth variation diagrams of grain size, reflectance factor scores, and magnetic susceptibility were compared to identify paleo-environmental signals. PCA analysis of reflectance data identified three principle components which describe 92% of the variance while a similar analysis performed for grain size data identifies six components describing 98% of the variance. Downcore variation plots show that a*, b* and the reflectance factor scores representing sediment goethite and iron oxide content have a strong correlation with grain size factors representing the medium sand, silt and clay size classes. Sand layers deposited by 2004 tsunami event and by similar older events can be clearly recognized using these parameters. Magnetic susceptibility plots also show peaks in some of the same sand layers indicating the association of magnetic mineral-rich beach sand. Downcore plots of these petrophysical parameters show a significant abrupt change in the signal at about 2 m below the surface. According to an age model constructed for a nearby lagoon by Jackson (2009) this break dates back about 6000 yrs BP. This break may represent the mid Holocene sea level transgression, which resulted in about 1.5 m sea level rise in Sri Lanka (Katupota, 1995) Correlation of multi proxy downcore variation plots from Kirinda lagoon with geomorphologically and geographically different lagoons on the eastern coast would enable distinguishing different coastal events in the Holocene history.

Imaging Management of Breast Density, a Controversial Risk Factor for Breast Cancer.

PubMed

Falcon, Shannon; Williams, Angela; Weinfurtner, Jared; Drukteinis, Jennifer S

2017-04-01

Breast density is well recognized as an independent risk factor for the development of breast cancer. However, the magnitude of risk is controversial. As the public becomes increasingly aware of breast density as a risk factor, legislation and notification laws in relation to breast density have become common throughout the United States. Awareness of breast density as a risk factor for breast cancer presents new challenges for the clinician in the approach to the management and screening of women with dense breasts. The evidence and controversy surrounding breast density as a risk factor for the development of breast cancer are discussed. Common supplemental screening modalities for breast cancer are also discussed, including tomosynthesis, ultrasonography, and magnetic resonance imaging. A management strategy for screening women with dense breasts is also presented. The American College of Radiology recognizes breast density as a controversial risk factor for breast cancer, whereas the American Congress of Obstetricians and Gynecologists recognizes breast density as a modest risk factor. Neither organization recommends the routine use of supplemental screening in women with dense breasts without considering additional patient-related risk factors. Breast density is a poorly understood and controversial risk factor for the development of breast cancer. Mammography is a screening modality proven to reduce breast cancer-related mortality rates and is the single most appropriate tool for population-based screening. Use of supplemental screening modalities should be tailored to individual risk assessment.

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors.

PubMed

Batsuli, Glaivy; Deng, Wei; Healey, John F; Parker, Ernest T; Baldwin, W Hunter; Cox, Courtney; Nguyen, Brenda; Kahle, Joerg; Königs, Christoph; Li, Renhao; Lollar, Pete; Meeks, Shannon L

2016-10-20

Inhibitor formation in hemophilia A is the most feared treatment-related complication of factor VIII (fVIII) therapy. Most inhibitor patients with hemophilia A develop antibodies against the fVIII A2 and C2 domains. Recent evidence demonstrates that the C1 domain contributes to the inhibitor response. Inhibitory anti-C1 monoclonal antibodies (mAbs) have been identified that bind to putative phospholipid and von Willebrand factor (VWF) binding epitopes and block endocytosis of fVIII by antigen presenting cells. We now demonstrate by competitive enzyme-linked immunosorbent assay and hydrogen-deuterium exchange mass spectrometry that 7 of 9 anti-human C1 mAbs tested recognize an epitope distinct from the C1 phospholipid binding site. These mAbs, designated group A, display high binding affinities for fVIII, weakly inhibit fVIII procoagulant activity, poorly inhibit fVIII binding to phospholipid, and exhibit heterogeneity with respect to blocking fVIII binding to VWF. Another mAb, designated group B, inhibits fVIII procoagulant activity, fVIII binding to VWF and phospholipid, fVIIIa incorporation into the intrinsic Xase complex, thrombin generation in plasma, and fVIII uptake by dendritic cells. Group A and B epitopes are distinct from the epitope recognized by the canonical, human-derived inhibitory anti-C1 mAb, KM33, whose epitope overlaps both groups A and B. Antibodies recognizing group A and B epitopes are present in inhibitor plasmas from patients with hemophilia A. Additionally, group A and B mAbs increase fVIII clearance and are pathogenic in a hemophilia A mouse tail snip bleeding model. Group A anti-C1 mAbs represent the first identification of pathogenic, weakly inhibitory antibodies that increase fVIII clearance. © 2016 by The American Society of Hematology.

A Preliminary Analysis of Human Factors Affecting the Recognition Accuracy of a Discrete Word Recognizer for C3 Systems.

DTIC Science & Technology

1983-03-01

acoustic wave pattern and, if so, word recognitios would be a sliple matter of the voice recogniticn system scanning the pattern, comparing the slmple...TRAINING WEEL - EEK#1 ORD# UTTERANCE CRT PRCtMPT (co0THREE THREE (Oe1EUROPE ERP V)r;_ OVE IT LEFT MCV7 IT LEFT 01 !CARRIAGE RETURN CAER RETURN LOGOLT LOGO UT

Influence of quasi-specific sites on kinetics of target DNA search by a sequence-specific DNA-binding protein.

PubMed

Kemme, Catherine A; Esadze, Alexandre; Iwahara, Junji

2015-11-10

Functions of transcription factors require formation of specific complexes at particular sites in cis-regulatory elements of genes. However, chromosomal DNA contains numerous sites that are similar to the target sequences recognized by transcription factors. The influence of such "quasi-specific" sites on functions of the transcription factors is not well understood at present by experimental means. In this work, using fluorescence methods, we have investigated the influence of quasi-specific DNA sites on the efficiency of target location by the zinc finger DNA-binding domain of the inducible transcription factor Egr-1, which recognizes a 9 bp sequence. By stopped-flow assays, we measured the kinetics of Egr-1's association with a target site on 143 bp DNA in the presence of various competitor DNAs, including nonspecific and quasi-specific sites. The presence of quasi-specific sites on competitor DNA significantly decelerated the target association by the Egr-1 protein. The impact of the quasi-specific sites depended strongly on their affinity, their concentration, and the degree of their binding to the protein. To quantitatively describe the kinetic impact of the quasi-specific sites, we derived an analytical form of the apparent kinetic rate constant for the target association and used it for fitting to the experimental data. Our kinetic data with calf thymus DNA as a competitor suggested that there are millions of high-affinity quasi-specific sites for Egr-1 among the 3 billion bp of genomic DNA. This study quantitatively demonstrates that naturally abundant quasi-specific sites on DNA can considerably impede the target search processes of sequence-specific DNA-binding proteins.

Influence of Quasi-Specific Sites on Kinetics of Target DNA Search by a Sequence-Specific DNA-Binding Protein

PubMed Central

2015-01-01

Functions of transcription factors require formation of specific complexes at particular sites in cis-regulatory elements of genes. However, chromosomal DNA contains numerous sites that are similar to the target sequences recognized by transcription factors. The influence of such “quasi-specific” sites on functions of the transcription factors is not well understood at present by experimental means. In this work, using fluorescence methods, we have investigated the influence of quasi-specific DNA sites on the efficiency of target location by the zinc finger DNA-binding domain of the inducible transcription factor Egr-1, which recognizes a 9 bp sequence. By stopped-flow assays, we measured the kinetics of Egr-1’s association with a target site on 143 bp DNA in the presence of various competitor DNAs, including nonspecific and quasi-specific sites. The presence of quasi-specific sites on competitor DNA significantly decelerated the target association by the Egr-1 protein. The impact of the quasi-specific sites depended strongly on their affinity, their concentration, and the degree of their binding to the protein. To quantitatively describe the kinetic impact of the quasi-specific sites, we derived an analytical form of the apparent kinetic rate constant for the target association and used it for fitting to the experimental data. Our kinetic data with calf thymus DNA as a competitor suggested that there are millions of high-affinity quasi-specific sites for Egr-1 among the 3 billion bp of genomic DNA. This study quantitatively demonstrates that naturally abundant quasi-specific sites on DNA can considerably impede the target search processes of sequence-specific DNA-binding proteins. PMID:26502071

FY 2017-Influence of Sodium Environment on the Tensile Properties of Advanced Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Natesan, K.; Li, Meimei; Chen, Wei-Ying

This report provides an update on the understanding of the effects of sodium exposures on tensile properties of advanced alloy 709 in support of the design and operation of structural components in sodium-cooled fast reactors (SFRs). The report is a Level 3 deliverable in FY17 (M3AT-17AN1602093), under the Work Package AT-17AN160209, “Sodium Compatibility” performed by Argonne National Laboratory (ANL), as part of Advanced Reactor Technologies Program. Three laboratory-size heats of Alloy 709 austenitic steel were investigated in liquid sodium environments at 550-650°C to understand its corrosion behaviour, microstructural evolution, and tensile properties. In addition, a commercial scale heat has beenmore » produced and hot-rolled into plates.« less

UV-luminous, star-forming hosts of z ˜ 2 reddened quasars in the Dark Energy Survey

NASA Astrophysics Data System (ADS)

Wethers, C. F.; Banerji, M.; Hewett, P. C.; Lemon, C. A.; McMahon, R. G.; Reed, S. L.; Shen, Y.; Abdalla, F. B.; Benoit-Lévy, A.; Brooks, D.; Buckley-Geer, E.; Capozzi, D.; Carnero Rosell, A.; CarrascoKind, M.; Carretero, J.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; DePoy, D. L.; Desai, S.; Doel, P.; Flaugher, B.; Fosalba, P.; Frieman, J.; García-Bellido, J.; Gerdes, D. W.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; Honscheid, K.; James, D. J.; Jeltema, T.; Kuehn, K.; Kuhlmann, S.; Kuropatkin, N.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Martini, P.; Menanteau, F.; Miquel, R.; Nichol, R. C.; Nord, B.; Plazas, A. A.; Romer, A. K.; Sanchez, E.; Scarpine, V.; Schindler, R.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, M.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Tarle, G.; Walker, A. R.

2018-04-01

We present the first rest-frame UV population study of 17 heavily reddened, high-luminosity [E(B - V)QSO ≳ 0.5; Lbol > 1046 erg s-1] broad-line quasars at 1.5 < z < 2.7. We combine the first year of deep, optical, ground-based observations from the Dark Energy Survey (DES) with the near-infrared VISTA Hemisphere Survey and UKIDSS Large Area Survey data, from which the reddened quasars were initially identified. We demonstrate that the significant dust reddening towards the quasar in our sample allows host galaxy emission to be detected at the rest-frame UV wavelengths probed by the DES photometry. By exploiting this reddening effect, we disentangle the quasar emission from that of the host galaxy via spectral energy distribution fitting. We find evidence for a relatively unobscured, star-forming host galaxy in at least 10 quasars, with a further three quasars exhibiting emission consistent with either star formation or scattered light. From the rest-frame UV emission, we derive instantaneous, dust-corrected star formation rates (SFRs) in the range 25 < SFRUV < 365 M⊙ yr-1, with an average SFRUV = 130 ± 95 M⊙ yr-1. We find a broad correlation between SFRUV and the bolometric quasar luminosity. Overall, our results show evidence for coeval star formation and black hole accretion occurring in luminous, reddened quasars at the peak epoch of galaxy formation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shim, Hyunjin; Im, Myungshin; Jeon, Yiseul

We present spectra of 1796 sources selected in the AKARI North Ecliptic Pole Wide Survey field, obtained with MMT/Hectospec and WIYN/Hydra, for which we measure 1645 redshifts. We complemented the generic flux-limited spectroscopic surveys at 11 {mu}m and 15 {mu}m, with additional sources selected based on the MIR and optical colors. In MMT/Hectospec observations, the redshift identification rates are {approx}80% for objects with R < 21.5 mag. On the other hand, in WIYN/Hydra observations, the redshift identification rates are {approx}80% at R magnitudes brighter than 19 mag. The observed spectra were classified through the visual inspection or from the linemore » diagnostics. We identified 1128 star-forming or absorption-line-dominated galaxies, 198 Type-1 active galactic nuclei (AGNs), 8 Type-2 AGNs, 121 Galactic stars, and 190 spectra in unknown category due to low signal-to-noise ratio. The spectra were flux-calibrated but to an accuracy of 0.1-0.18 dex for most of the targets and worse for the remainder. We derive star formation rates (SFRs) from the mid-infrared fluxes or from the optical emission lines, showing that our sample spans an SFR range of 0.1 to a few hundred M{sub Sun} yr{sup -1}. We find that the extinction inferred from the difference between the IR and optical SFR increases as the IR luminosity increases but with a large scatter.« less

Self-Reported Use of Different Forms of Aggression in Late Adolescence and Emerging Adulthood

ERIC Educational Resources Information Center

Verona, Edelyn; Sadeh, Naomi; Case, Steve M.; Reed, Americus, II; Bhattacharjee, Amit

2008-01-01

Two studies investigated the psychometric properties of a self-report measure of commonly recognized forms of aggression (FOA) that could be used to efficiently gather aggression data in large samples. EFA and CFA in Study 1 suggested that a five-factor model (Physical, Property, Verbal, Relational, and Passive-Rational) best represented the data…

Serine/Arginine-rich Splicing Factor 2 Modulates Herpes Simplex Virus Type 1 Replication via Regulating Viral Gene Transcriptional Activity and Pre-mRNA Splicing.

PubMed

Wang, Ziqiang; Liu, Qing; Lu, Jinhua; Fan, Ping; Xie, Weidong; Qiu, Wei; Wang, Fan; Hu, Guangnan; Zhang, Yaou

2016-12-16

Once it enters the host cell, herpes simplex virus type 1 (HSV-1) recruits a series of host cell factors to facilitate its life cycle. Here, we demonstrate that serine/arginine-rich splicing factor 2 (SRSF2), which is an important component of the splicing speckle, mediates HSV-1 replication by regulating viral gene expression at the transcriptional and posttranscriptional levels. Our results indicate that SRSF2 functions as a transcriptional activator by directly binding to infected cell polypeptide 0 (ICP0), infected cell polypeptide 27 (ICP27), and thymidine kinase promoters. Moreover, SRSF2 participates in ICP0 pre-mRNA splicing by recognizing binding sites in ICP0 exon 3. These findings provide insight into the functions of SRSF2 in HSV-1 replication and gene expression. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion.

PubMed

Tanzawa, Takehito; Kato, Koji; Girodat, Dylan; Ose, Toyoyuki; Kumakura, Yuki; Wieden, Hans-Joachim; Uchiumi, Toshio; Tanaka, Isao; Yao, Min

2018-04-06

Archaea and eukaryotes have ribosomal P stalks composed of anchor protein P0 and aP1 homodimers (archaea) or P1•P2 heterodimers (eukaryotes). These P stalks recruit translational GTPases to the GTPase-associated center in ribosomes to provide energy during translation. The C-terminus of the P stalk is known to selectively recognize GTPases. Here we investigated the interaction between the P stalk and elongation factor 2 by determining the structures of Pyrococcus horikoshii EF-2 (PhoEF-2) in the Apo-form, GDP-form, GMPPCP-form (GTP-form), and GMPPCP-form bound with 11 C-terminal residues of P1 (P1C11). Helical structured P1C11 binds to a hydrophobic groove between domain G and subdomain G' of PhoEF-2, where is completely different from that of aEF-1α in terms of both position and sequence, implying that such interaction characteristic may be requested by how GTPases perform their functions on the ribosome. Combining PhoEF-2 P1-binding assays with a structural comparison of current PhoEF-2 structures and molecular dynamics model of a P1C11-bound GDP form, the conformational changes of the P1C11-binding groove in each form suggest that in response to the translation process, the groove has three states: closed, open, and release for recruiting and releasing GTPases.

Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues.

PubMed

Sato, Aya; Suematsu, Takuma; Aihara, Koh-Ki; Kita, Kiyoshi; Suzuki, Tsutomu; Watanabe, Kimitsuna; Ohtsuki, Takashi; Watanabe, Yoh-Ichi

2017-03-07

Translation elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to ribosomes in protein synthesis. EF-Tu generally recognizes aminoacyl moieties and acceptor- and T-stems of aa-tRNAs. However, nematode mitochondrial (mt) tRNAs frequently lack all or part of the T-arm that is recognized by canonical EF-Tu. We previously reported that two distinct EF-Tu species, EF-Tu1 and EF-Tu2, respectively, recognize mt tRNAs lacking T-arms and D-arms in the mitochondria of the chromadorean nematode Caenorhabditis elegans C. elegans EF-Tu2 specifically recognizes the seryl moiety of serylated D-armless tRNAs. Mitochondria of the enoplean nematode Trichinella possess three structural types of tRNAs: T-armless tRNAs, D-armless tRNAs, and cloverleaf tRNAs with a short T-arm. Trichinella mt EF-Tu1 binds to all three types and EF-Tu2 binds only to D-armless Ser-tRNAs, showing an evolutionary intermediate state from canonical EF-Tu to chromadorean nematode (e.g. C. elegans ) EF-Tu species. We report here that two EF-Tu species also participate in Drosophila melanogaster mitochondria. Both D. melanogaster EF-Tu1 and EF-Tu2 bound to cloverleaf and D-armless tRNAs. D. melanogaster EF-Tu1 has the ability to recognize T-armless tRNAs that do not evidently exist in D. melanogaster mitochondria, but do exist in related arthropod species. In addition, D. melanogaster EF-Tu2 preferentially bound to aa-tRNAs carrying small amino acids, but not to aa-tRNAs carrying bulky amino acids. These results suggest that the Drosophila mt translation system could be another intermediate state between the canonical and nematode mitochondria-type translation systems. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation

PubMed Central

Joo, Yoo Jin; Ficarro, Scott B.; Soares, Luis M.; Chun, Yujin; Marto, Jarrod A.; Buratowski, Stephen

2017-01-01

TFIID binds promoter DNA to recruit RNA polymerase II and other basal factors for transcription. Although the TATA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the TBP-associated factor (TAF) subunits recognize downstream promoter elements, act as coactivators, and interact with nucleosomes. In yeast nuclear extracts, transcription induces stable TAF binding to downstream promoter DNA, promoting subsequent activator-independent transcription reinitiation. In vivo, promoter responses to TAF mutations correlate with the level of downstream, rather than overall, Taf1 cross-linking. We propose a new model in which TAFs function as reinitiation factors, accounting for the differential responses of promoters to various transcription factor mutations. PMID:29203645

Cripto-1 in Mammary Gland Development and Carcinogenesis

DTIC Science & Technology

2000-12-01

Task 4). T.O. 2 We have designed and tested a hammerhead ribozyme [21, 22] that recognizes nucleotides 12-28 of the murine CR-I mRNA and cuts after the...Growth Factors, Ribozymes 23 16. PRICE CODE 17. SECURITY CLASSIFICATION 18. SECURITY CLASSIFICATION 19. SECURITY CLASSIFICATION 20. LIMITATION OF...Underexpression of CR-1 will decrease tumorigenicity of highly or moderately tumorigenic cell lines. (T.O. 2) 4. Efficient delivery of a ribozyme or

Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.

PubMed

Zhang, Chun Li; McKinsey, Timothy A; Olson, Eric N

2002-10-01

Class II histone deacetylases (HDACs) 4, 5, 7, and 9 repress muscle differentiation through associations with the myocyte enhancer factor 2 (MEF2) transcription factor. MEF2-interacting transcription repressor (MITR) is an amino-terminal splice variant of HDAC9 that also potently inhibits MEF2 transcriptional activity despite lacking a catalytic domain. Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase. Promyogenic signals provided by calcium/calmodulin-dependent kinase (CaMK) disrupt the interaction of MITR and HDACs with HP1. Since the histone methyl-lysine residues recognized by HP1 also serve as substrates for deacetylation by HDACs, the interaction of MITR and HDACs with HP1 provides an efficient mechanism for silencing MEF2 target genes by coupling histone deacetylation and methylation. Indeed, nucleosomal histones surrounding a MEF2-binding site in the myogenin gene promoter are highly methylated in undifferentiated myoblasts, when the gene is silent, and become acetylated during muscle differentiation, when the myogenin gene is expressed at high levels. The ability of MEF2 to recruit a histone methyltransferase to target gene promoters via HP1-MITR and HP1-HDAC interactions and of CaMK signaling to disrupt these interactions provides an efficient mechanism for signal-dependent regulation of the epigenetic events controlling muscle differentiation.

Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle Differentiation

PubMed Central

Zhang, Chun Li; McKinsey, Timothy A.; Olson, Eric N.

2002-01-01

Class II histone deacetylases (HDACs) 4, 5, 7, and 9 repress muscle differentiation through associations with the myocyte enhancer factor 2 (MEF2) transcription factor. MEF2-interacting transcription repressor (MITR) is an amino-terminal splice variant of HDAC9 that also potently inhibits MEF2 transcriptional activity despite lacking a catalytic domain. Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase. Promyogenic signals provided by calcium/calmodulin-dependent kinase (CaMK) disrupt the interaction of MITR and HDACs with HP1. Since the histone methyl-lysine residues recognized by HP1 also serve as substrates for deacetylation by HDACs, the interaction of MITR and HDACs with HP1 provides an efficient mechanism for silencing MEF2 target genes by coupling histone deacetylation and methylation. Indeed, nucleosomal histones surrounding a MEF2-binding site in the myogenin gene promoter are highly methylated in undifferentiated myoblasts, when the gene is silent, and become acetylated during muscle differentiation, when the myogenin gene is expressed at high levels. The ability of MEF2 to recruit a histone methyltransferase to target gene promoters via HP1-MITR and HP1-HDAC interactions and of CaMK signaling to disrupt these interactions provides an efficient mechanism for signal-dependent regulation of the epigenetic events controlling muscle differentiation. PMID:12242305

Far-Infrared and Nebular Star-Formation Rate of Dusty Star Forming Galaxies from Herschel, CANDELS and 3D-HST at z~1

NASA Astrophysics Data System (ADS)

Hasan, Farhanul; Nayyeri, Hooshang; Cooray, Asantha R.; Herschel Group: University of California Irvine. Dept. of Physics & Astronomy. Led by professor Asantha Cooray, Reed College Undergraduate Research Committee

2017-06-01

We present a combined Herschel/PACS and SPIRE and HST/WFC3 observations of the five CANDELS fields, EGS, GOODS-N, GOODS-S, COSMOS and UDS, to study star-formation activity in dusty star-forming galaxies (DSFGs) at z~1. We use 3D-HST photometry and Grism spectroscopic redshifts to construct the Spectral Energy Distributions (SED) of galaxies in the near UV, optical and near infrared, along with IRAC measurements at 3.6-8 μm in the mid-infrared, and Herschel data at 250-500 μm in the far-infrared. The 3D-HST grism line measurements are used to estimate the star-formation rate from nebular emission. In particular, we compare the H-alpha measured SFRs (corrected for attenuation) to that of direct observations of the far-infrared from Herschel. We further look at the infrared excess in this sample of dusty star-forming galaxies (denoted by LIR/LUV) as a function of the UV slope. We find that the population of high-z DSFGs sit above the trend expected for normal star-forming galaxies. Additionally, we study the dependence of SFR on total dust attenuation and confirm a strong correlation between SFR(Ha) and the balmer decrement (Hα/Hβ).

Human Factors Integration Requirements for Armoured Fighting Vehicles (AFVs). Part 1: Guidance on Addressing the Human System Integration (HSI) Content of Statements of Operational Requirements (SORs)

DTIC Science & Technology

1999-12-01

based on a systematic analysis of future systems, within the context of future scenarios and operational/support concepts . It is recognized, however...INFORMATION DISTRIBUTION CONCEPTS 2 6 IDENTIFY GAPS IN EXISTING KNOWLEDGE 2 7 DEVEWP FUTURE R&D PROGRAM ····· . 1 1 ...... 2 . . 2...stems Incorporated Annex B. Soldier’s Day Concept Page I ... mounted soldier performance can therefore be improved, and mounted/ dismounted

Searching for Lyman-alpha Emitters as a Probe of Cosmic Reionization and Peering Inside Galaxies in the First Two Billion Years

NASA Astrophysics Data System (ADS)

Jung, Intae; Finkelstein, Steven; CANDELS team

2018-01-01

In the reionization era an immediately accessible method for studying the intergalactic medium is to measure the equivalent width distribution of Lyman-alpha emission from galaxies with follow-up spectroscopy. To search for Lyman-alpha emission from galaxies at z ~ 5-8, we perform spectroscopic observations of candidate galaxies from the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). We utilize data from the Keck DEIMOS (optical) and MOSFIRE (near-infrared) spectrographs, ensuring a comprehensive wavelength coverage of Lyman-alpha emission at z ~ 5-8. We have a total of 1170 object-hours of spectroscopic integration of galaxies at z > 5: 118 galaxies with DEIMOS and 69 galaxies with MOSFIRE. The equivalent width distribution of Lyman-alpha emission is constrained with the number of detected objects from our dataset by constructing detailed simulations of mock emission lines, which consider observational conditions and the photometric redshift probability distribution function. We present our robust measure of the evolution of the Lyman-alpha emission equivalent width distribution at z ~ 5-8.Understanding what drives star-formation quenching in the early universe is a long-standing puzzle. To reveal the hidden relation of quenching with galaxy structural properties, particularly central stellar mass density, we perform the first spatially resolved stellar population study of galaxies at z ~ 4, utilizing the CANDELS imaging data set over the GOODS-S field. We examine 166 photometric-redshift-selected galaxies at 3.5 < z < 4.0 with additional deep K-band survey data from the HAWK-I UDS and GOODS Survey which covers the 4000Å break at these redshifts. We estimate the stellar mass, star formation rate, and dust extinction for galaxy inner and outer regions via spatially resolved spectral energy distribution fitting based on a Markov Chain Monte Carlo algorithm. By comparing specific star formation rates (sSFRs) between inner and outer parts of the galaxies we find that the majority of galaxies with high central mass densities show evidence for a preferentially lower sSFR in their centers than in their outer regions, indicative of reduced sSFRs in their central regions.

STAR FORMATION IN DWARF GALAXIES OF THE NEARBY CENTAURUS A GROUP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cote, Stephanie; Draginda, Adam; Skillman, Evan D.

2009-10-15

We present H{alpha} narrow-band imaging of 17 dwarf irregular (dI) galaxies in the nearby Centaurus A Group. Although all large galaxies of the group are or recently have been through a period of enhanced star formation, the dIs have normal star formation rates (SFRs) and do not contain a larger fraction of dwarf starbursts than other nearby groups such as the Sculptor Group or the Local Group. Most of the galaxies in the group now have fairly accurately known distances, which enables us to obtain relative distances between dIs and larger galaxies of the group. We find that the dImore » SFRs do not depend on local environment, and in particular they do not show any correlation with the distance of the dI to the nearest large galaxy of the group. There is a clear morphology-density relation in the Centaurus A Group, similar to the Sculptor Group and Local Group, in the sense that dwarf ellipticals (dEs)/dwarf spheroidals (dSphs) tend to be at small distances from the more massive galaxies of the group, while dIs are on average at larger distances. We find four transition dwarfs in the Group, dwarfs that show characteristics of both dE/dSphs and dIs, and which contain cold gas but no current star formation. Interestingly, the transition dwarfs have an average distance to the more massive galaxies, which is intermediate between those of the dEs/dSphs and dIs and which is quite large: 0.54 {+-} 0.31 Mpc. This large distance poses some difficulty for the most popular scenarios proposed for transforming a dI into a dE/dSph (ram-pressure with tidal stripping or galaxy harassment). If the observed transition dwarfs are indeed missing links between dIs and dE/dSphs, their relative isolation makes it less likely to have been produced by these mechanisms. An inhomogeneous intergalactic medium containing higher density clumps would be able to ram-pressure strip the dIs at larger distances from the more massive galaxies of the group.« less

GAMMA-RAY BURST HOST GALAXY SURVEYS AT REDSHIFT z {approx}> 4: PROBES OF STAR FORMATION RATE AND COSMIC REIONIZATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trenti, Michele; Perna, Rosalba; Levesque, Emily M.

2012-04-20

Measuring the star formation rate (SFR) at high redshift is crucial for understanding cosmic reionization and galaxy formation. Two common complementary approaches are Lyman break galaxy (LBG) surveys for large samples and gamma-ray burst (GRB) observations for sensitivity to SFR in small galaxies. The z {approx}> 4 GRB-inferred SFR is higher than the LBG rate, but this difference is difficult to understand, as both methods rely on several modeling assumptions. Using a physically motivated galaxy luminosity function model, with star formation in dark matter halos with virial temperature T{sub vir} {approx}> 2 Multiplication-Sign 10{sup 4} K (M{sub DM} {approx}> 2more » Multiplication-Sign 10{sup 8} M{sub Sun }), we show that GRB- and LBG-derived SFRs are consistent if GRBs extend to faint galaxies (M{sub AB} {approx}< -11). To test star formation below the detection limit L{sub lim} {approx} 0.05L*{sub z=3} of LBG surveys, we propose to measure the fraction f{sub det}(L > L{sub lim}, z) of GRB hosts with L > L{sub lim}. This fraction quantifies the missing star formation fraction in LBG surveys, constraining the mass-suppression scale for galaxy formation, with weak dependence on modeling assumptions. Because f{sub det}(L > L{sub lim}, z) corresponds to the ratio of SFRs derived from LBG and GRB surveys, if these estimators are unbiased, measuring f{sub det}(L > L{sub lim}, z) also constrains the redshift evolution of the GRB production rate per unit mass of star formation. Our analysis predicts significant success for GRB host detections at z {approx} 5 with f{sub det}(L > L{sub lim}, z) {approx} 0.4, but rarer detections at z > 6. By analyzing the upper limits on host galaxy luminosities of six z > 5 GRBs from literature data, we infer that galaxies with M{sub AB} > -15 were present at z > 5 at 95% confidence, demonstrating the key role played by very faint galaxies during reionization.« less

Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

PubMed Central

Srikanthan, Krithika; Feyh, Andrew; Visweshwar, Haresh; Shapiro, Joseph I.; Sodhi, Komal

2016-01-01

Introduction: Metabolic syndrome represents a cluster of related metabolic abnormalities, including central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance, with central obesity and insulin resistance in particular recognized as causative factors. These metabolic derangements present significant risk factors for cardiovascular disease, which is commonly recognized as the primary clinical outcome, although other outcomes are possible. Metabolic syndrome is a progressive condition that encompasses a wide array of disorders with specific metabolic abnormalities presenting at different times. These abnormalities can be detected and monitored via serum biomarkers. This review will compile a list of promising biomarkers that are associated with metabolic syndrome and this panel can aid in early detection and management of metabolic syndrome in high risk populations, such as in West Virginia. Methods: A literature review was conducted using PubMed, Science Direct, and Google Scholar to search for markers related to metabolic syndrome. Biomarkers searched included adipokines (leptin, adiponectin), neuropeptides (ghrelin), pro-inflammatory cytokines (IL-6, TNF-α), anti-inflammatory cytokines (IL-10), markers of antioxidant status (OxLDL, PON-1, uric acid), and prothrombic factors (PAI-1). Results: According to the literature, the concentrations of pro-inflammatory cytokines (IL-6, TNF-α), markers of pro-oxidant status (OxLDL, uric acid), and prothrombic factors (PAI-1) were elevated in metabolic syndrome. Additionally, leptin concentrations were found to be elevated in metabolic syndrome as well, likely due to leptin resistance. In contrast, concentrations of anti-inflammatory cytokines (IL-10), ghrelin, adiponectin, and antioxidant factors (PON-1) were decreased in metabolic syndrome, and these decreases also correlated with specific disorders within the cluster. Conclusion: Based on the evidence presented within the literature, the aforementioned biomarkers correlate significantly with metabolic syndrome and could provide a minimally-invasive means for early detection and specific treatment of these disorders. Further research is encouraged to determine the efficacy of applying these biomarkers to diagnosis and treatment in a clinical setting. PMID:26816492

Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ping; Mueller, Steffen; Morais, Marc C.

2010-11-02

When poliovirus (PV) recognizes its receptor, CD155, the virus changes from a 160S to a 135S particle before releasing its genome into the cytoplasm. CD155 is a transmembrane protein with 3 Ig-like extracellular domains, D1-D3, where D1 is recognized by the virus. The crystal structure of D1D2 has been determined to 3.5-{angstrom} resolution and fitted into {approx}8.5-{angstrom} resolution cryoelectron microscopy reconstructions of the virus-receptor complexes for the 3 PV serotypes. These structures show that, compared with human rhinoviruses, the virus-receptor interactions for PVs have a greater dependence on hydrophobic interactions, as might be required for a virus that can inhabitmore » environments of different pH. The pocket factor was shown to remain in the virus during the first recognition stage. The present structures, when combined with earlier mutational investigations, show that in the subsequent entry stage the receptor moves further into the canyon when at a physiological temperature, thereby expelling the pocket factor and separating the viral subunits to form 135S particles. These results provide a detailed analysis of how a nonenveloped virus can enter its host cell.« less

Occupational dermatitis in hairdressers - influence of individual and environmental factors.

PubMed

Carøe, Tanja K; Ebbehøj, Niels E; Agner, Tove

2017-03-01

Hairdressers are at risk of developing occupational contact dermatitis because of their intense contact with wet work in combination with chemicals. To perform an analysis of a cohort study of hairdressers with occupational contact dermatitis recognized in the period 2006-2011, focusing on individual and environmental factors associated with the disease. The study was a descriptive, register-based survey including all hairdressers with recognized occupational contact dermatitis in Denmark in the period January 2006 to September 2011. Data were obtained from the Danish National Board of Industrial Injuries. The study comprised 381 patients (373 women and 8 men). The median age was 25 years, 64.8% were apprentices, and 35.2% were fully trained hairdressers. The prevalence of atopic dermatitis was 36.0%, and was significantly higher among apprentices than among fully trained hairdressers (44.9% and 19.4%, respectively) (p < 0.001). Of the patients, 48.3% had their dermatitis recognized as occupational irritant contact dermatitis, 46.7% had their dermatitis recognized as as occupational allergic contact dermatitis or combined allergic and irritant contact dermatitis, and 5.0% were recognized as having occupational contact urticaria. The low median age, the high percentages of atopic dermatitis in apprentices and the fact that more apprentices than fully trained hairdressers had recognized occupational contact dermatitis underlines the importance of early prevention. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Problem Solving and Immigrant Student Mathematics and Science Achievement: Multination Findings from the Programme for International Student Assessment (PISA)

ERIC Educational Resources Information Center

Martin, Andrew J.; Liem, Gregory A. D.; Mok, Magdalena M. C.; Xu, Jacob

2012-01-01

The present study investigates problem-solving skill alongside more widely recognized settlement and sociodemographic factors in first-generation (1G) and second-generation (2G) immigrant students' science and mathematics achievement. A total of 113,767 students (ages 15-16 years) from 17 countries were drawn from the 2003 Programme for…

Schools and Students At Risk. Context and Framework for Positive Change.

ERIC Educational Resources Information Center

Rossi, Robert J., Ed.

This book presents essays from educational reformers who examine efforts aimed at students at risk for failure in U.S. schools. It is divided into four parts. Part 1 considers the factors that place children at risk for educational failure. Part 2 describes the dangers for students of a system that fails to recognize and appreciate their…

Nutrient Content of Foods, Nutritional Supplements, and Food Fallacies. Nutrition in Primary Care Series, Number 1.

ERIC Educational Resources Information Center

Gallagher-Allred, Charlette R.; Stein, Joan Z.

Nutrition is well-recognized as a necessary component of educational programs for physicians. This is to be valued in that of all factors affecting health in the United States, none is more important than nutrition. This can be argued from various perspectives, including health promotion, disease prevention, and therapeutic management. In all…

Retinopathy of prematurity - from recognition of risk factors to treatment recommendations.

PubMed

Fagerholm, Reija; Vesti, Eija

Retinopathy of prematurity is a proliferative retinal disorder diagnosed exclusively in prematurely born infants. In retinopathy of prematurity, growth of the retinal vasculature is disturbed, leading to hypoxia-induced pathological changes typical of retinopathy of prematurity, in the worst case resulting in retinal detachment. The most typical risk factors predisposing to the disease include hyperoxemia, low levels of insulin-like growth factor 1 (IGF-I), and low birth weight in relation to weeks of pregnancy. Laser therapy of peripheral retina is the currently established form of treatment. Screening is applied in order to recognize the pathological changes in retinopathy of prematurity early enough.

Wolf population regulation revisited: again

USGS Publications Warehouse

McRoberts, Ronald E.; Mech, L. David

2014-01-01

The long-accepted conclusion that wolf density is regulated by nutrition was recently challenged, and the conclusion was reached that, at greater levels of prey biomass, social factors such as intraspecific strife and territoriality tend to regulate wolf density. We reanalyzed the data used in that study for 2 reasons: 1) we disputed the use of 2 data points, and 2) because of recognized heteroscedasticity, we used weighted-regression analysis instead of the unweighted regressions used in the original study. We concluded that the data do not support the hypothesis that wolf densities are regulated by social factors.

Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells.

PubMed

Patil, Rajeshwari H; Babu, R L; Naveen Kumar, M; Kiran Kumar, K M; Hegde, Shubha M; Nagesh, Rashmi; Ramesh, Govindarajan T; Sharma, S Chidananda

2016-02-01

Apigenin is one of the plant flavonoids present in fruits and vegetables, acting as an important nutraceutical component. It is recognized as a potential antioxidant, antimicrobial, and anti-inflammatory molecule. In the present study, the mechanism of anti-inflammatory action of apigenin on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and activator protein-1 (AP-1) factors in human lung A549 cells was investigated. The anti-inflammatory activity of apigenin on LPS-induced inflammation was determined by analyzing the expression of pro-inflammatory cytokines, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and different AP-1 factors. Apigenin significantly inhibited the LPS-induced expression of iNOS, COX-2, expression of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, and TNF-α), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production. Study confirms the anti-inflammatory effect of apigenin by inhibiting the expression of inflammatory mediators and AP-1 factors involved in the inflammation and its importance in the treatment of lung inflammatory diseases.

Star Formation in the Central Regions of Galaxies

NASA Astrophysics Data System (ADS)

Tsai, Mengchun

2015-08-01

The galactic central region connects the galactic nucleus to the host galaxy. If the central black hole co-evolved with the host galaxies, there should be some evidence left in the central region. We use the environmental properties in the central regions such as star-forming activity, stellar population and molecular abundance to figure out a possible scenario of the evolution of galaxies. In this thesis at first we investigated the properties of the central regions in the host galaxies of active and normal galaxies. We used radio emission around the nuclei of the host galaxies to represent activity of active galactic nuclei (AGNs), and used infrared ray (IR) emission to represent the star-forming activity and stellar population of the host galaxies. We determined that active galaxies have higher stellar masses (SMs) within the central kiloparsec radius than normal galaxies do independent of the Hubble types of the host galaxies; but both active and normal galaxies exhibit similar specific star formation rates (SSFRs). We also discovered that certain AGNs exhibit substantial inner stellar structures in the IR images; most of the AGNs with inner structures are Seyferts, whereas only a few LINERs exhibit inner structures. We note that the AGNs with inner structures show a positive correlation between the radio activity of the AGNs and the SFRs of the host galaxies, but the sources without inner structures show a negative correlation between the radio power and the SFRs. These results might be explained with a scenario of starburst-AGN evolution. In this scenario, AGN activities are triggered following a nuclear starburst; during the evolution, AGN activities are accompanied by SF activity in the inner regions of the host galaxies; at the final stage of the evolution, the AGNs might transform into LINERs, exhibiting weak SF activity in the central regions of the host galaxies. For further investigation about the inner structure, we choose the most nearby and luminous Seyfert galaxy with inner structure as an example. In this thesis, we present CO(3-2) interferometric observations of the central region of the Seyfert 2 galaxy NGC1068 using the Submillimeter Array, together with CO(1-0) data taken with the Owens Valley Radio Observatory Millimeter Array. Both the CO(3-2) and CO(1-0) emission lines are mainly distributed within ~5 arcsec of the nucleus and along the spiral arms, but the intensity distributions show differences; the CO(3-2) map peaks in the nucleus, while the CO(1-0) emission is mainly located along the spiral arms. The CO(3-2)/CO(1-0) ratio is about 3.1 in the nucleus, which is four times as large as the average line ratio in the spiral arms, suggesting that the molecular gas there must be affected by the radiation arising from the AGN. On the other hand, the line ratios in the spiral arms vary over a wide range from 0.24 to 2.34 with a average value around 0.75, which is similar to the line ratios of star-formation regions, indicating that the molecular gas is affected by star formation. Besides, we see a tight correlation between CO(3-2)/(1-0) ratios in the spiral arms and star formation rate surface densities derived from Spitzer 8 micron dust flux densities. We also compare the CO(3-2)/(1-0) ratio and the star formation rate at different positions within the spiral arms; both are found to decrease as the radius from the nucleus increases.

46 CFR 31.10-1 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Recognized classification society-TB/ALL. 31.10-1... CERTIFICATION Inspections § 31.10-1 Recognized classification society—TB/ALL. (a) In the inspection of hulls... Shipping, or other recognized classification society for classed vessels, may be accepted by the Coast...

46 CFR 31.10-1 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Recognized classification society-TB/ALL. 31.10-1... CERTIFICATION Inspections § 31.10-1 Recognized classification society—TB/ALL. (a) In the inspection of hulls... Shipping, or other recognized classification society for classed vessels, may be accepted by the Coast...

Physical Properties of Sub-galactic Clumps at 0.5 ≤ Z ≤ 1.5 in the UVUDF

NASA Astrophysics Data System (ADS)

Soto, Emmaris; de Mello, Duilia F.; Rafelski, Marc; Gardner, Jonathan P.; Teplitz, Harry I.; Koekemoer, Anton M.; Ravindranath, Swara; Grogin, Norman A.; Scarlata, Claudia; Kurczynski, Peter; Gawiser, Eric

2017-03-01

We present an investigation of clumpy galaxies in the Hubble Ultra Deep Field at 0.5≤slant z≤slant 1.5 in the rest-frame far-ultraviolet (FUV) using Hubble Space Telescope Wide Field Camera 3 broadband imaging in F225W, F275W, and F336W. An analysis of 1404 galaxies yields 209 galaxies that host 403 kpc scale clumps. These host galaxies appear to be typical star-forming galaxies, with an average of 2 clumps per galaxy and reaching a maximum of 8 clumps. We measure the photometry of the clumps and determine the mass, age, and star formation rates (SFR) using the spectral energy distribution fitting code FAST. We find that clumps make an average contribution of 19% to the total rest-frame FUV flux of their host galaxy. Individually, clumps contribute a median of 5% to the host galaxy SFR and an average of ˜4% to the host galaxy mass, with total clump contributions to the host galaxy stellar mass ranging widely from lower than 1% up to 93%. Clumps in the outskirts of galaxies are typically younger, with higher SFRs, than clumps in the inner regions. The results are consistent with clump migration theories in which clumps form through violent gravitational instabilities in gas-rich turbulent disks, eventually migrate toward the center of the galaxies, and coalesce into the bulge.

A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter.

PubMed

Corthésy, B; Cardinaux, J R; Claret, F X; Wahli, W

1989-12-01

A hormone-controlled in vitro transcription system derived from Xenopus liver nuclear extracts was exploited to identify novel cis-acting elements within the vitellogenin gene B1 promoter region. In addition to the already well-documented estrogen-responsive element (ERE), two elements were found within the 140 base pairs upstream of the transcription initiation site. One of them, a negative regulatory element, is responsible for the lack of promoter activity in the absence of the hormone and, as demonstrated by DNA-binding assays, interacts with a liver-specific transcription factor. The second is required in association with the estrogen-responsive element to mediate hormonal induction and is recognized by the Xenopus liver homolog of nuclear factor I.

Pseudotumor of the pituitary due to PROP-1 deletion.

PubMed

Teinturier, C; Vallette, S; Adamsbaum, C; Bendaoud, M; Brue, T; Bougnères, P F

2002-01-01

Hypopituitarism associated with pituitary mass in childhood is most frequently the consequence of craniopharyngioma or Rathke's cleft cyst. We report a patient with an intrasellar pseudotumor associated with hypopituitarism, which led us to a misdiagnosis of intrasellar craniopharyngioma. After spontaneous involution of the mass, diagnosis was revised. DNA analysis showed a deletion in the Prophet of Pit-1 (PROP-1) gene, a pituitary transcription factor. It is important to recognize that a PROP-1 deletion can cause pituitary pseudotumor that can be mistaken for a craniopharyngioma or Rathke's pouch cyst.

Management of children and young people (CYP) with asthma: a clinical audit report.

PubMed

Levy, Mark L; Ward, Angela; Nelson, Sara

2018-05-21

An asthma attack or exacerbation signals treatment failure. Most attacks are preventable and failure to recognize risk of asthma attacks are well recognized as risk factors for future attacks and even death. Of the 19 recommendations made by the United Kingdom National Review of Asthma Deaths (NRAD) (1) only one has been partially implemented-a National Asthma Audit; however, this hasn't reported yet. The Harrow Clinical Commissioning Group (CCG) in London implemented a clinical asthma audit on 291 children and young people aged under 19 years (CYP) who had been treated for asthma attacks in 2016. This was funded as a Local Incentive Scheme (LIS) aimed at improving quality health care delivery. Two years after the publication of the NRAD report it is surprising that risks for future attacks were not recognized, that few patients were assessed objectively during attacks and only 10% of attacks were followed up within 2 days. However, it is encouraging that CYP hospital admissions following the audit were reduced by 16%, with clear benefit for patients, their families and the local health economy. This audit has provided an example of how clinicians can focus learning on patients who have had asthma attacks and utilize these events as a catalyst for active reflection in particular on modifiable risk factors. Through identification of these risks and active optimization of management, preventable asthma attacks could become 'never events'.

26 CFR 1.1374-2 - Net recognized built-in gain.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Net recognized built-in gain. 1.1374-2 Section 1... (CONTINUED) INCOME TAXES Small Business Corporations and Their Shareholders § 1.1374-2 Net recognized built-in gain. (a) In general. An S corporation's net recognized built-in gain for any taxable year is the...

Recognition of mental disorders among a multiracial population in Southeast Asia.

PubMed

Chong, Siow Ann; Abdin, Edimansyah; Picco, Louisa; Pang, Shirlene; Jeyagurunathan, Anitha; Vaingankar, Janhavi Ajit; Kwok, Kian Woon; Subramaniam, Mythily

2016-05-04

Mental health literacy is an important mediating factor in help-seeking behavior. An important component of this literacy is the proper recognition of mental disorders. The aim of this population-based study in Singapore was to determine the proportion of adults in the resident population who were able to recognize vignettes pertaining to alcohol abuse, dementia, depression, obsessive compulsive disorder (OCD) and schizophrenia correctly. The sociodemographic characteristics that were associated with the ability to correctly recognize these disorders were also examined. This was a nationwide cross-sectional study that involved establishing mental health literacy using a vignette approach. Respondents were recruited using a disproportionate stratified sampling design by age and ethnic groups. Face-to face-interviews were conducted with respondents aged 18 to 65 years belonging to Chinese, Malay, Indian and Other ethnic groups. A total of 3,006 respondents completed the survey (response rate of 71%). The most well recognized conditions were dementia (66.3%), alcohol abuse (57.1%) and depression (55.2%). The least recognized were OCD (28.7%) and schizophrenia (11.5%). Younger age and higher educational levels were found to be significant factors associated with the better recognition of specific disorders. The relatively high rate of recognition of dementia was likely to be due to the emphasis on public education programmes on dementia which is viewed as an emerging challenge due to Singapore's rapidly ageing population. The role of education and the portrayal of depression and alcohol related problems in the local mass media are possible influences in their better recognition as compared to OCD and schizophrenia. Sociodemographic characteristics influencing mental health literacy need to be considered in planning intervention strategies that target mental health literacy.

The ionisation parameter of star-forming galaxies evolves with the specific star formation rate

NASA Astrophysics Data System (ADS)

Kaasinen, Melanie; Kewley, Lisa; Bian, Fuyan; Groves, Brent; Kashino, Daichi; Silverman, John; Kartaltepe, Jeyhan

2018-04-01

We investigate the evolution of the ionisation parameter of star-forming galaxies using a high-redshift (z ˜ 1.5) sample from the FMOS-COSMOS survey and matched low-redshift samples from the Sloan Digital Sky Survey. By constructing samples of low-redshift galaxies for which the stellar mass (M*), star formation rate (SFR) and specific star formation rate (sSFR) are matched to the high-redshift sample we remove the effects of an evolution in these properties. We also account for the effect of metallicity by jointly constraining the metallicity and ionisation parameter of each sample. We find an evolution in the ionisation parameter for main-sequence, star-forming galaxies and show that this evolution is driven by the evolution of sSFR. By analysing the matched samples as well as a larger sample of z < 0.3, star-forming galaxies we show that high ionisation parameters are directly linked to high sSFRs and are not simply the byproduct of an evolution in metallicity. Our results are physically consistent with the definition of the ionisation parameter, a measure of the hydrogen ionising photon flux relative to the number density of hydrogen atoms.

The nature of H α-selected galaxies along the large-scale structure at z = 0.4 revealed by Subaru Hyper Suprime-Cam survey

NASA Astrophysics Data System (ADS)

Koyama, Yusei; Hayashi, Masao; Tanaka, Masayuki; Kodama, Tadayuki; Shimakawa, Rhythm; Yamamoto, Moegi; Nakata, Fumiaki; Tanaka, Ichi; Suzuki, Tomoko L.; Tadaki, Ken-ichi; Nishizawa, Atsushi J.; Yabe, Kiyoto; Toba, Yoshiki; Lin, Lihwai; Jian, Hung-Yu; Komiyama, Yutaka

2018-01-01

We present the environmental dependence of color, stellar mass, and star formation (SF) activity in Hα-selected galaxies along the large-scale structure at z = 0.4 hosting twin clusters in the DEEP2-3 field, discovered by the Subaru Strategic Program of Hyper Suprime-Cam (HSC SSP). By combining photo-z-selected galaxies and Hα emitters selected with broadband and narrowband (NB) data from the recent data release of HSC SSP (DR1), we confirm that galaxies in higher-density environments or galaxies in cluster central regions show redder colors. We find that there still remains a possible color-density and color-radius correlation even if we restrict the sample to Hα-selected galaxies, probably due to the presence of massive Hα emitters in denser regions. We also find a hint of increased star formation rates (SFR) amongst Hα emitters toward the highest-density environment, again primarily driven by the excess of red/massive Hα emitters in high-density environments, while their specific SFRs do not significantly change with environment. This work demonstrates the power of the HSC SSP NB data for studying SF galaxies across environments in the distant universe.

ENHANCED STAR FORMATION OF LESS MASSIVE GALAXIES IN A PROTOCLUSTER AT z = 2.5

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayashi, Masao; Kodama, Tadayuki; Tanaka, Ichi

2016-08-01

We investigate a correlation between star formation rate (SFR) and stellar mass for H α emission-line galaxies (HAEs) in one of the richest protoclusters ever known at z∼2.5, the USS 1558-003 protocluster. This study is based on a 9.7 hr narrowband imaging data with MOIRCS on the Subaru telescope. We are able to construct a sample in combination with additional H -band data taken with WFC3 on the Hubble Space Telescope , of 100 HAEs reaching the dust-corrected SFRs down to 3 M {sub ⊙} yr{sup −1} and the stellar masses down to 10{sup 8.0} M {sub ⊙}. We findmore » that while the star-forming galaxies with ≳10{sup 9.3} M {sub ⊙} are located on the universal SFR-mass main sequence (MS) irrespective of the environment, less massive star-forming galaxies with ≲10{sup 9.3} M {sub ⊙} show a significant upward scatter from the MS in this protocluster. This suggests that some less massive galaxies are in a starburst phase, although we do not know yet if this is due to environmental effects.« less

USF-related transcription factor, HIV-TF1, stimulates transcription of human immunodeficiency virus-1.

PubMed

Maekawa, T; Sudo, T; Kurimoto, M; Ishii, S

1991-09-11

The transcription factor HIV-TF1, which binds to a region about 60 bp upstream from the enhancer of the human immunodeficiency virus-1 (HIV-1), was purified from human B cells. HIV-TF1 had a molecular weight of 39,000. Binding of HIV-TF1 to the HIV long terminal repeat (LTR) activated transcription from the HIV promoter in vitro. The HIV-TF1-binding site in HIV LTR was similar to the site recognized by upstream stimulatory factor (USF) in the adenovirus major late promoter. DNA-binding properties of HIV-TF1 suggested that HIV-TF1 might be identical or related to USF. Interestingly, treatment of purified HIV-TF1 by phosphatase greatly reduced its DNA-binding activity, suggesting that phosphorylation of HIV-TF1 was essential for DNA binding. The disruption of HIV-TF1-binding site induced a 60% decrease in the level of transcription from the HIV promoter in vivo. These results suggest that HIV-TF1 is involved in transcriptional regulation of HIV-1.

Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells.

PubMed

Singh, Mrinalini; Tulsawani, Rajkumar; Koganti, Praveen; Chauhan, Amitabh; Manickam, Manimaran; Misra, Kshipra

2013-01-01

Cordyceps sinensis, an edible mushroom growing in Himalayan regions, is widely recognized in traditional system of medicine. In the present study, we report the efficacy of Cordyceps sinensis in facilitating tolerance to hypoxia using A549 cell line as a model system. Treatment with aqueous extract of Cordyceps sinensis appreciably attenuated hypoxia induced ROS generation, oxidation of lipids and proteins and maintained antioxidant status similar to that of controls via induction of antioxidant gene HO1 (heme oxygenase-1), MT (metallothionein) and Nrf2 (nuclear factor erythroid-derived 2-like 2). In contrast, lower level of NF κ B (nuclear factor kappaB) and tumor necrosis factor- α observed which might be due to higher levels of HO1, MT and transforming growth factor- β . Further, increase in HIF1 (hypoxia inducible factor-1) and its regulated genes; erythropoietin, vascular endothelial growth factor, and glucose transporter-1 was observed. Interestingly, Cordyceps sinensis treatment under normoxia did not regulate the expression HIF1, NF κ B and their regulated genes evidencing that Cordyceps sinensis per se did not have an effect on these transcription factors. Overall, Cordyceps sinensis treatment inhibited hypoxia induced oxidative stress by maintaining higher cellular Nrf2, HIF1 and lowering NF κ B levels. These findings provide a basis for possible use of Cordyceps sinensis in tolerating hypoxia.

Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells

PubMed Central

Manickam, Manimaran; Misra, Kshipra

2013-01-01

Cordyceps sinensis, an edible mushroom growing in Himalayan regions, is widely recognized in traditional system of medicine. In the present study, we report the efficacy of Cordyceps sinensis in facilitating tolerance to hypoxia using A549 cell line as a model system. Treatment with aqueous extract of Cordyceps sinensis appreciably attenuated hypoxia induced ROS generation, oxidation of lipids and proteins and maintained antioxidant status similar to that of controls via induction of antioxidant gene HO1 (heme oxygenase-1), MT (metallothionein) and Nrf2 (nuclear factor erythroid-derived 2-like 2). In contrast, lower level of NFκB (nuclear factor kappaB) and tumor necrosis factor-α observed which might be due to higher levels of HO1, MT and transforming growth factor-β. Further, increase in HIF1 (hypoxia inducible factor-1) and its regulated genes; erythropoietin, vascular endothelial growth factor, and glucose transporter-1 was observed. Interestingly, Cordyceps sinensis treatment under normoxia did not regulate the expression HIF1, NFκB and their regulated genes evidencing that Cordyceps sinensis per se did not have an effect on these transcription factors. Overall, Cordyceps sinensis treatment inhibited hypoxia induced oxidative stress by maintaining higher cellular Nrf2, HIF1 and lowering NFκB levels. These findings provide a basis for possible use of Cordyceps sinensis in tolerating hypoxia. PMID:24063008

Innate immunity against HIV-1 infection.

PubMed

Altfeld, Marcus; Gale, Michael

2015-06-01

During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling cascade that initiates innate intracellular antiviral defenses aimed at restricting the replication and spread of the virus. This cell-intrinsic response propagates outward via the action of secreted factors such as cytokines and chemokines that activate innate immune cells and attract them to the site of infection and to local lymphatic tissue. Antiviral innate effector cells can subsequently contribute to the control of viremia and modulate the quality of the adaptive immune response to HIV-1. The concerted actions of PRR signaling, specific viral-restriction factors, innate immune cells, innate-adaptive immune crosstalk and viral evasion strategies determine the outcome of HIV-1 infection and immune responses.

Factors associated with physical inactivity among school-going adolescents: data from the Malaysian School-Based Nutrition Survey 2012.

PubMed

Baharudin, Azli; Zainuddin, Ahmad Ali; Manickam, Mala A; Ambak, Rashidah; Ahmad, Mohamad Hasnan; Naidu, Balkish Mahadir; Cheong, Siew Man; Ying, Chan Ying; Saad, Hazizi Abu; Ahmad, Noor Ani

2014-09-01

The importance of physical activity to health is well recognized. Good health habits should begin from a young age. This article aims to explore physical activity among Malaysian school adolescents and factors associated with it. Data from the Malaysian School-Based Nutrition Survey (MSNS), comprising a nationally representative sample of school-going children aged 10 to 17 years, were used. The overall prevalence of physically inactive adolescents was 57.3%. Age in years (adjusted odds ratio = 1.2; 95% confidence interval = 1.16-1.23), gender - females (adjusted odds ratio = 2.9; 95% confidence interval = 2.66-3.10), afternoon school session, breakfast consumption (no breakfast and irregular breakfast), body mass index status (obese and underweight), and body weight perception (underweight perceivers) were significant factors associated with physical inactivity among Malaysian adolescents. Thus, there is evidence that programs to promote physical activity in this group should consider the combination of the aforementioned factors at the household, school, and community levels. © 2014 APJPH.

Wood decay and the cleanup crew

Treesearch

Kevin T. Smith; Jessie A. Glaeser

2017-01-01

Arborists are encouraged to recognize the wood-decay process as an important factor in tree health and public safety. Technical experts who develop training materials to recognize wood-decay processes in living trees are frequently forest pathologists. Much of the history of forest pathology was to support production of sound, high-quality timber. That heritage is...

Recognizing and managing sapstreak disease of sugar maple

Treesearch

David R. Houston; David R. Houston

1993-01-01

Sapstreak disease, a potentially serious problem of sugarbushes and forest stands, occurs when the causal fungus, Ceratocystis virescens, invades the sapwood of roots and bases of stems through wounds inflicted during logging, saphauling, or other activities. Describes how to recognize the disease, the factors that affect its occurrence and development, and management...

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.

PubMed

Osman, Narin; Grande-Allen, K Jane; Ballinger, Mandy L; Getachew, Robel; Marasco, Silvana; O'Brien, Kevin D; Little, Peter J

2013-01-01

Calcific aortic valve disease is a progressive condition that shares some common pathogenic features with atherosclerosis. Transforming growth factor-β1 is a recognized mediator of atherosclerosis and is expressed in aortic valve lesions. Transforming growth factorβ1 stimulates glycosaminoglycan elongation of proteoglycans that is associated with increased lipid binding. We investigated the presence of transforming growth factor-β1 and downstream signaling intermediates in diseased human aortic valves and the effects of activated transforming growth factor-β1 receptor signaling on aortic valve interstitial cell proteoglycan synthesis and lipid binding as a possible mechanism for the initiation of the early lesion of calcific aortic valve disease. Diseased human aortic valve leaflets demonstrated strong immunohistochemical staining for transforming growth factor-β1 and phosphorylated Smad2/3. In primary porcine aortic valve interstitial cells, Western blots showed that transforming growth factor-β1 stimulated phosphorylation in both the carboxy and linker regions of Smad2/3, which was inhibited by the transforming growth factor-β1 receptor inhibitor SB431542. Gel electrophoresis and size exclusion chromatography demonstrated that SB431542 decreased transforming growth factor-β1-mediated [(35)S]-sulfate incorporation into proteoglycans in a dose-dependent manner. Further, in proteoglycans derived from transforming growth factor-β1-treated valve interstitial cells, gel mobility shift assays demonstrated that inhibition of transforming growth factor-β1 receptor signaling resulted in decreased lipid binding. Classic transforming growth factor-β1 signaling is present in human aortic valves in vivo and contributes to the modification of proteoglycans expressed by valve interstitial cells in vitro. These findings suggest that transforming growth factor-β1 may promote increased low-density lipoprotein binding in the early phases of calcific aortic valve disease. Copyright © 2013 Elsevier Inc. All rights reserved.

Delay in Recognition of Pulmonary Arterial Hypertension

PubMed Central

Brown, Lynette M.; Chen, Hubert; Halpern, Scott; Taichman, Darren; McGoon, Michael D.; Farber, Harrison W.; Frost, Adaani E.; Liou, Theodore G.; Turner, Michelle; Feldkircher, Kathy; Miller, Dave P.

2011-01-01

Background: Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder. Despite the emergence of effective therapy, PAH is commonly at an advanced stage when recognized. Factors associated with a prolonged symptomatic period before the recognition of PAH have not been fully evaluated. Methods: The Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL Registry) enrolled 2,967 US adult patients with PAH from March 2006 to September 2007. Patients were considered to have delayed disease recognition if > 2 years elapsed between symptom onset and the patient receiving a PAH diagnosis, starting on PAH-specific therapy, or receiving a diagnosis by right-sided heart catheterization. Results: In 21.1% of patients, symptoms were experienced for > 2 years before PAH was recognized. Patients with onset of PAH symptoms before age 36 years showed the highest likelihood of delayed disease recognition (OR, 3.07; 95% CI, 2.03-4.66). History of obstructive airways disease (OR, 1.93; 95% CI, 1.5-2.47) and sleep apnea (OR, 1.72; 95% CI, 1.33-2.22) were independently associated with delayed PAH recognition. Six-minute walk distance < 250 m (OR, 1.91; 95% CI, 1.16-3.13), right atrial pressure < 10 mm Hg (OR, 1.77; 95% CI, 1.26-2.48), and pulmonary vascular resistance < 10 Wood units (OR, 1.28; 95% CI, 1.02-1.60) were also associated with delayed disease recognition, but sex, race/ethnicity, and geographic region showed no association. Conclusions: One in five patients in the REVEAL Registry who were diagnosed with PAH reported symptoms for > 2 years before their disease was recognized. Younger individuals and patients with histories of common respiratory disorders were most likely to experience delayed PAH recognition. Trial registry: ClinicalTrials.gov; No.: NCT00370214; URL: www.clinicaltrials.gov PMID:21393391

Diabetes mellitus: an important risk factor for reactivation of tuberculosis.

PubMed

Solá, Ernesto; Rivera, Carmen; Mangual, Michelle; Martinez, José; Rivera, Kelvin; Fernandez, Ricardo

2016-01-01

Diabetes mellitus was identified as a risk factor for developing tuberculosis (TB) infection, and relapse after therapy. The risk of acquiring TB is described as comparable to that of HIV population. The fact that diabetics are 3× times more prone to develop pulmonary TB than nondiabetics cannot be overlooked. With DM recognized as global epidemic, and TB affecting one-third of the world population, physicians must remain vigilant. We present a 45-year-old woman born in Dominican Republic (DR), with 10-year history of T2DM treated with metformin, arrived to our Urgency Room complaining of dry cough for the past 3months. Interview unveiled unintentional 15lbs weight loss, night sweats, occasional unquantified fever, and general malaise but denied bloody sputum. She traveled to DR 2years before, with no known ill exposure. Physical examination showed a thin body habitus, otherwise well appearing woman with stable vital signs, presenting solely right middle lung field ronchi. LDH, ESR, hsCRP and Hg A1C were elevated. Imaging revealed a right middle lobe cavitation. Sputum for AFB disclosed active pulmonary TB. Our case portrays that the consideration of TB as differential diagnosis in diabetics should be exercised with the same strength, as it is undertaken during the evaluation of HIV patients with lung cavitation. Inability to recognize TB will endanger the patient, hospital dwellers and staff, and perpetuate this global public health menace. Diabetes mellitus should be considered an important risk factor for the reactivation of pulmonary tuberculosis.High clinical suspicious should be taken into consideration as radiological findings for pulmonary tuberculosis in patients with diabetes mellitus may be atypical, involving middle and lower lobes.Inability to recognize pulmonary tuberculosis will endanger the patient, hospital dwellers and staff, and perpetuate this global public health menace.

Scaling of Advanced Theory-of-Mind Tasks.

PubMed

Osterhaus, Christopher; Koerber, Susanne; Sodian, Beate

2016-11-01

Advanced theory-of-mind (AToM) development was investigated in three separate studies involving 82, 466, and 402 elementary school children (8-, 9-, and 10-year-olds). Rasch and factor analyses assessed whether common conceptual development underlies higher-order false-belief understanding, social understanding, emotion recognition, and perspective-taking abilities. The results refuted a unidimensional scale and revealed three distinct AToM factors: social reasoning, reasoning about ambiguity, and recognizing transgressions of social norms. Developmental progressions emerged for the two reasoning factors but not for recognizing transgressions of social norms. Both social factors were significantly related to inhibition, whereas language development only predicted performance on social reasoning. These findings suggest that AToM comprises multiple abilities, which are subject to distinct cognitive influences. Importantly, only two AToM factors involve conceptual development. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro.

PubMed

Chorley, Brian N; Crews, Anne L; Li, Yuehua; Adler, Kenneth B; Minnicozzi, Michael; Martin, Linda D

2006-02-25

Mucus overproduction is a characteristic of inflammatory pulmonary diseases including asthma, chronic bronchitis, and cystic fibrosis. Expression of two mucin genes, MUC2 and MUC5AC, and their protein products (mucins), is modulated in certain disease states. Understanding the signaling mechanisms that regulate the production and secretion of these major mucus components may contribute significantly to development of effective therapies to modify their expression in inflamed airways. To study the differential expression of Muc2 and Muc5ac, a novel monoclonal antibody recognizing guinea pig Muc2 and a commercially-available antibody against human MUC5AC were optimized for recognition of specific guinea pig mucins by enzyme-linked immunosorbent assay (ELISA), Western blot, and immunohistochemistry (IHC). These antibodies were then used to analyze expression of Muc2 and another mucin subtype (likely Muc5ac) in guinea pig tracheal epithelial (GPTE) cells stimulated with a mixture of pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interferon- gamma (IFN-gamma)]. The anti-Muc2 (C4) and anti-MUC5AC (45M1) monoclonal antibodies specifically recognized proteins located in Muc2-dominant small intestinal and Muc5ac-dominant stomach mucosae, respectively, in both Western and ELISA experimental protocols. IHC protocols confirmed that C4 recognizes murine small intestine mucosal proteins while 45M1 does not react. C4 and 45M1 also stained specific epithelial cells in guinea pig lung sections. In the resting state, Muc2 was recognized as a highly expressed intracellular mucin in GPTE cells in vitro. Following cytokine exposure, secretion of Muc2, but not the mucin recognized by the 45M1 antibody (likely Muc5ac), was increased from the GPTE cells, with a concomitant increase in intracellular expression of both mucins. Given the tissue specificity in IHC and the differential hybridization to high molecular weight proteins by Western blot, we conclude that the antibodies used in this study can recognize specific mucin subtypes in guinea pig airway epithelium and in proteins from GPTE cells. In addition, Muc2 is highly expressed constitutively, modulated by inflammation, and secreted differentially (as compared to Muc5ac) in GPTE cells. This finding contrasts with expression patterns in the airway epithelium of a variety of mammalian species in which only Muc5ac predominates.

Differing roles for zinc fingers in DNA recognition: Structure of a six-finger transcription factor IIIA complex

PubMed Central

Nolte, Robert T.; Conlin, Rachel M.; Harrison, Stephen C.; Brown, Raymond S.

1998-01-01

The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 Å resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove. PMID:9501194

Hypoxia inducible factor 1 (HIF-1) and cardioprotection

PubMed Central

Tekin, Demet; Dursun, Ali D; Xi, Lei

2010-01-01

Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH regulation, cell proliferation and viability. Evidence accumulated during the past 7 years suggests a critical role for HIF-1α in mediating cardioprotection. The purpose of our present article is to provide an updated overview on this important regulator of gene expression in the cellular stress-responsive and adaptive process. We have particularly emphasized the involvement of HIF-1 in the induction of cardioprotective molecules, such as inducible nitric oxide synthase (iNOS), hemeoxygenase 1 (HO-1), and erythropoietin (EPO), which in turn alleviate myocardial damages caused by harmful events such as ischemia-reperfusion injury. Despite these advances, further in-depth studies are needed to elucidate the possible coordination or interaction between HIF-1α and other key transcription factors in regulating protein expression that leads to cardioprotection. PMID:20711226

A second cistron in the CACNA1A gene encodes a transcription factor that mediates cerebellar development and SCA6

PubMed Central

Du, Xiaofei; Wang, Jun; Zhu, Haipeng; Rinaldo, Lorenzo; Lamar, Kay-Marie; Palmenberg, Ann C.; Hansel, Christian; Gomez, Christopher M.

2014-01-01

SUMMARY The CACNA1A gene, encoding the voltage-gated calcium channel subunit α1A, is involved in pre- and postsynaptic Ca2+ signaling, gene expression, and several genetic neurological disorders. We found that CACNA1A employs a novel strategy to directly coordinate a gene expression program, using a bicistronic mRNA bearing a cryptic internal ribosomal entry site (IRES). The first cistron encodes the well-characterized α1A subunit. The second expresses a newly-recognized transcription factor, α1ACT, that coordinates expression of a program of genes involved in neural and Purkinje cell development. α1ACT also contains the polyglutamine (polyQ) tract that, when expanded, causes spinocerebellar ataxia type 6 (SCA6). When expressed as an independent polypeptide, α1ACT, bearing an expanded polyQ tract, lacks transcription factor function and neurite outgrowth properties, causes cell death in culture, and leads to ataxia and cerebellar atrophy in transgenic mice. Suppression of CACNA1A IRES function in SCA6 may be a potential therapeutic strategy. PMID:23827678

The relationship of depression with the level of blood pressure in population-based Kangbuk Samsung Health Study.

PubMed

Park, Sung Keun; Jung, Ju Young; Ryoo, Jae-Hong; Oh, Chang-Mo; Lee, Jae-Hon; Pan, Zihang; Mansur, Rodrigo B; Shekotikhina, Margarita; McIntyre, Roger S; Choi, Joong-Myung

2018-05-01

There has been increasing evidence about psychosomatic relationship between mood disorder and blood pressure (BP). However, the degree to which BP categories are associated with depression has been less well described. Thus, this study was to investigate the association of depression with BP categories. A total of 90,643 men and 68,933 women were enrolled in this study. They were stratified into four groups (normal, prehypertension, newly diagnosed hypertension, and recognized hypertension) according to the BP levels and the history of hypertension. Center for Epidemiological Studies-Depression was used to evaluate the depressive symptom, and the degree of depression was evaluated by the cutoff of Center for Epidemiological Studies-Depression (mild: 16-20, moderate: 21-24, severe: ≥25). The multivariate logistic regression was used in calculating odds ratios for depression according to the four BP categories, with adjustment for multiple confounding factors. Subgroup analysis was conducted by gender and age. The adjusted odds ratios for depression tended to decrease from normal to newly diagnosed hypertension, but significantly increased in recognized hypertension (normal: reference, prehypertension: 0.85 [0.80-0.91], newly diagnosed hypertension: 0.75 [0.65-0.86], recognized hypertension: 1.11 [1.03-1.20]). Subgroup analysis also indicated the similar pattern of relationship, which was more prominent in male and middle-aged subgroup than any other subgroups. Depression was inversely associated with elevated BP. However, recognized hypertension had the increased likelihood of depression in male and young age group. These findings suggest that the association between depression and BP may be moderated by the chronicity of hypertension in men and young individuals. Copyright © 2018 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.

26 CFR 1.1374-4 - Recognized built-in gain or loss.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 11 2014-04-01 2014-04-01 false Recognized built-in gain or loss. 1.1374-4... Recognized built-in gain or loss. (a) Sales and exchanges—(1) In general. Section 1374(d)(3) or 1374(d)(4) applies to any gain or loss recognized during the recognition period in a transaction treated as a sale or...

26 CFR 1.1374-4 - Recognized built-in gain or loss.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Recognized built-in gain or loss. 1.1374-4... Recognized built-in gain or loss. (a) Sales and exchanges—(1) In general. Section 1374(d)(3) or 1374(d)(4) applies to any gain or loss recognized during the recognition period in a transaction treated as a sale or...

26 CFR 1.1374-4 - Recognized built-in gain or loss.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 11 2013-04-01 2013-04-01 false Recognized built-in gain or loss. 1.1374-4... Recognized built-in gain or loss. (a) Sales and exchanges—(1) In general. Section 1374(d)(3) or 1374(d)(4) applies to any gain or loss recognized during the recognition period in a transaction treated as a sale or...

26 CFR 1.1374-4 - Recognized built-in gain or loss.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Recognized built-in gain or loss. 1.1374-4... Recognized built-in gain or loss. (a) Sales and exchanges—(1) In general. Section 1374(d)(3) or 1374(d)(4) applies to any gain or loss recognized during the recognition period in a transaction treated as a sale or...

Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein.

PubMed Central

Gaur, R K; Valcárcel, J; Green, M R

1995-01-01

Splicing of pre-mRNAs occurs via a lariat intermediate in which an intronic adenosine, embedded within a branch point sequence, forms a 2',5'-phosphodiester bond (RNA branch) with the 5' end of the intron. How the branch point is recognized and activated remains largely unknown. Using site-specific photochemical cross-linking, we have identified two proteins that specifically interact with the branch point during the splicing reaction. U2AF65, an essential splicing factor that binds to the adjacent polypyrimidine tract, crosslinks to the branch point at the earliest stage of spliceosome formation in an ATP-independent manner. A novel 28-kDa protein, which is a constituent of the mature spliceosome, contacts the branch point after the first catalytic step. Our results indicate that the branch point is sequentially recognized by distinct splicing factors in the course of the splicing reaction. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 PMID:7493318

Children's Understanding of Health and Health-Related Behavior: The Influence of Age and Information Source

ERIC Educational Resources Information Center

Daigle, Kay; Hebert, Edward; Humphries, Charlotte

2007-01-01

Background: Health is recognized as an important factor in children's educational achievement, and school-based health education programs are recognized for their potential long-term impact. However, the extent to which children conceptualize health similarly as adults, and the nature of their understandings of health, remain cloudy. Purpose:…

A case study of an extremely luminous, highly spatially extended starburst only 1.7Gyr after the Big Bang

NASA Astrophysics Data System (ADS)

Farrah, Duncan

2017-08-01

Luminous starbursts, systems with SFRs exceeding 1000Msun yr-1, are predicted to be extremely rare at z>3. However, recent observations find such systems at rates of tens to hundreds above predictions. This discrepancy is extremely difficult to explain. Case studies of such luminous starbursts are thus of profound importance to understand how star formation is triggered and quenched at z > 3, and help reconcile models with observations. Our group has been intensively studying the quasar SDSS J160705.16, at z = 3.65 (or 1.7Gyr after the Big Bang). This quasar is an excellent case study of luminous star formation at z > 3, and how AGN activity may affect such star formation. SDSS J160705.16 harbors both a broad-line, luminous quasar and an extremely high star formation rate, with an AGN luminosity of 10^47 ergs s-1 and an SFR of 2000 Msol yr-1. Sub-mm interferometry has further revealed that the star formation is highly spatially extended on scales up to 40kpc. Furthermore, VLA observations show an emerging 4kpc radio jet.We here propose WFC3 imaging with the following goals: (1) to set precise constraints on any lensing magnification, (2) to determine the morphology and color structure of the extended star formation, (3) to compare the optical morphology of the star formation to that seen in the sub-mm data, and (4) to search for evidence that SDSS J160705.16 resides in a protocluster.

Factors Influencing Army Accessions.

DTIC Science & Technology

1982-12-01

partial autocorrelations were examined for significant lags or a recognizable pattern such as a damped exponential or a sine wave. The TSP prugrams...decreasing function indicating nonstation- *arity or a very long sine wave where only a small portion of the wave is plotted. The partial...plot of the raw data appeared (Appendix E-1) to be either the middle of a long sine wave or a linearly decreasing function. This pattern is recognized

How aromatic compounds block DNA binding of HcaR catabolite regulator

DOE PAGES

Kim, Youngchang; Joachimiak, Grazyna; Bigelow, Lance; ...

2016-04-25

Bacterial catabolism of aromatic compounds from various sources including phenylpropanoids and flavonoids that are abundant in soil plays an important role in the recycling of carbon in the ecosystem. We have determined the crystal structures of apo-HcaR from Acinetobacter sp. ADP1, a MarR/SlyA transcription factor, in complexes with hydroxycinnamates and a specific DNA operator. The protein regulates the expression of the hca catabolic operon in Acinetobacter and related bacterial strains, allowing utilization of hydroxycinnamates as sole sources of carbon. HcaR binds multiple ligands, and as a result the transcription of genes encoding several catabolic enzymes is increased. The 1.9-2.4 Åmore » resolution structures presented here explain how HcaR recognizes four ligands (ferulate, 3,4-dihydroxybenzoate, p-coumarate, and vanillin) using the same binding site. The ligand promiscuity appears to be an adaptation to match a broad specificity of hydroxycinnamate catabolic enzymes while responding to toxic thioester intermediates. Structures of apo-HcaR and in complex with a specific DNA hca operator when combined with binding studies of hydroxycinnamates show how aromatic ligands render HcaR unproductive in recognizing a specific DNA target. Furthermore, the current study contributes to a better understanding of the hca catabolic operon regulation mechanism by the transcription factor HcaR.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Youngchang; Joachimiak, Grazyna; Bigelow, Lance

Bacterial catabolism of aromatic compounds from various sources including phenylpropanoids and flavonoids that are abundant in soil plays an important role in the recycling of carbon in the ecosystem. We have determined the crystal structures of apo-HcaR from Acinetobacter sp. ADP1, a MarR/SlyA transcription factor, in complexes with hydroxycinnamates and a specific DNA operator. The protein regulates the expression of the hca catabolic operon in Acinetobacter and related bacterial strains, allowing utilization of hydroxycinnamates as sole sources of carbon. HcaR binds multiple ligands, and as a result the transcription of genes encoding several catabolic enzymes is increased. The 1.9-2.4 Åmore » resolution structures presented here explain how HcaR recognizes four ligands (ferulate, 3,4-dihydroxybenzoate, p-coumarate, and vanillin) using the same binding site. The ligand promiscuity appears to be an adaptation to match a broad specificity of hydroxycinnamate catabolic enzymes while responding to toxic thioester intermediates. Structures of apo-HcaR and in complex with a specific DNA hca operator when combined with binding studies of hydroxycinnamates show how aromatic ligands render HcaR unproductive in recognizing a specific DNA target. Furthermore, the current study contributes to a better understanding of the hca catabolic operon regulation mechanism by the transcription factor HcaR.« less

AP1 Keeps Chromatin Poised for Action | Center for Cancer Research

Cancer.gov

The human genome harbors gene-encoding DNA, the blueprint for building proteins that regulate cellular function. Embedded across the genome, in non-coding regions, are DNA elements to which regulatory factors bind. The interaction of regulatory factors with DNA at these sites modifies gene expression to modulate cell activity. In cells, DNA exists in a complex with proteins called chromatin that compacts the DNA in the nucleus, strongly restricting access to DNA sequences. As a result, regulatory factors only interact with a small subset of their potential binding elements in a given cell to regulate genes. How factors recognize and select sites in chromatin across the genome is not well understood -- but several discoveries in CCR’s Laboratory of Receptor Biology and Gene Expression (LRBGE) have shed light on the mechanisms that direct factors to DNA.

Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.

PubMed

Zandarashvili, Levani; White, Mark A; Esadze, Alexandre; Iwahara, Junji

2015-07-08

The inducible transcription factor Egr-1 binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. Although it appears that complete CpG methylation would make an unfavorable steric clash in the previous crystal structures of the complexes with unmethylated or partially methylated DNA, our affinity data suggest that DNA recognition by Egr-1 is insensitive to CpG methylation. We have determined, at a 1.4-Å resolution, the crystal structure of the Egr-1 zinc-finger complex with completely methylated target DNA. Structural comparison of the three different methylation states reveals why Egr-1 can recognize the target sequences regardless of CpG methylation. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Modeling and Validation of Sodium Plugging for Heat Exchangers in Sodium-cooled Fast Reactor Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferroni, Paolo; Tatli, Emre; Czerniak, Luke

The project “Modeling and Validation of Sodium Plugging for Heat Exchangers in Sodium-cooled Fast Reactor Systems” was conducted jointly by Westinghouse Electric Company (Westinghouse) and Argonne National Laboratory (ANL), over the period October 1, 2013- March 31, 2016. The project’s motivation was the need to provide designers of Sodium Fast Reactors (SFRs) with a validated, state-of-the-art computational tool for the prediction of sodium oxide (Na 2O) deposition in small-diameter sodium heat exchanger (HX) channels, such as those in the diffusion bonded HXs proposed for SFRs coupled with a supercritical CO 2 (sCO 2) Brayton cycle power conversion system. In SFRs,more » Na 2O deposition can potentially occur following accidental air ingress in the intermediate heat transport system (IHTS) sodium and simultaneous failure of the IHTS sodium cold trap. In this scenario, oxygen can travel through the IHTS loop and reach the coldest regions, represented by the cold end of the sodium channels of the HXs, where Na 2O precipitation may initiate and continue. In addition to deteriorating HX heat transfer and pressure drop performance, Na 2O deposition can lead to channel plugging especially when the size of the sodium channels is small, which is the case for diffusion bonded HXs whose sodium channel hydraulic diameter is generally below 5 mm. Sodium oxide melts at a high temperature well above the sodium melting temperature such that removal of a solid plug such as through dissolution by pure sodium could take a lengthy time. The Sodium Plugging Phenomena Loop (SPPL) was developed at ANL, prior to this project, for investigating Na 2O deposition phenomena within sodium channels that are prototypical of the diffusion bonded HX channels envisioned for SFR-sCO 2 systems. In this project, a Computational Fluid Dynamic (CFD) model capable of simulating the thermal-hydraulics of the SPPL test section and provided with Na 2O deposition prediction capabilities, was developed. This state-of-the-art computational tool incorporates a first-principles Na 2O deposition model developed by ANL, and combines it with predictive capabilities for the spatial and temporal variation of temperature, velocity, dissolved oxygen concentration, and wall temperature under flowing sodium conditions. The CFD model was validated under no-deposition conditions using experimental data collected with the SPPL, demonstrating the model’s capability to predict the thermal-hydraulics of the SPPL test section within the measurement uncertainty characterizing the SPPL instrumentation. The model’s deposition prediction capability was not, however, validated as the SPPL could not be operated under plugging conditions during the project, resulting in the lack of deposition data with adequate pedigree for a CFD model validation. Two novel diagnostic techniques to detect and characterize Na 2O deposits, i.e. Ultrasonic Time Domain Reflectometry (UTDR) and Potential Drop (PD) techniques, were developed to ultimately assist in the validation effort under plugging conditions, which can be performed once the SPPL becomes operational. This development effort consisted first in demonstrating, analytically and/or computationally, the capability of these techniques to diagnose Na 2O deposits inside of small channels (particularly the deposit’s thickness), and subsequently in the fabrication and testing of prototypical UTDR and PD instrumentation. The testing, performed on mockups of the SPPL test section, demonstrated the capability of these techniques to detect and characterize material discontinuities like those induced by sodium oxide deposition on stainless steel channel walls. Because of the mentioned impossibility to run the SPPL in a plugging mode, the developed instrumentation could not be tested in-situ, i.e. at the SPPL while deposits are being formed inside of the SPPL test section. Recommended future work includes a possible enhancement in the CFD modeling technique and installation of the developed UTDR and PD instrumentation on the test section, followed by plugging tests to be conducted with the SPPL. The installation of the UTDR and PD diagnostic instrumentation on the SPPL test section will allow collection of Na 2O deposition data after the onset of deposition to nearly complete channel plugging, which can ultimately be used for the validation of the CFD model.« less

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

PubMed Central

2014-01-01

Background Retroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized. Results Here we show that the zinc finger protein Krüppel-like Factor 3 (KLF3) specifically silences transcription from the ORR1A0 long terminal repeat in murine fetal and adult erythroid cells. In the absence of KLF3, we detect widespread transcription from ORR1A0 elements driven by the master erythroid regulator KLF1. In several instances these aberrant transcripts are spliced to downstream genic exons. One such chimeric transcript produces a novel, dominant negative isoform of PU.1 that can induce erythroid differentiation. Conclusions We propose that KLF3 ensures the integrity of the murine erythroid transcriptome through the selective repression of a particular retroelement and is likely one of multiple sequence-specific factors that cooperate to achieve global silencing. PMID:24946810

A Comparison of Distribution Free and Non-Distribution Free Factor Analysis Methods

ERIC Educational Resources Information Center

Ritter, Nicola L.

2012-01-01

Many researchers recognize that factor analysis can be conducted on both correlation matrices and variance-covariance matrices. Although most researchers extract factors from non-distribution free or parametric methods, researchers can also extract factors from distribution free or non-parametric methods. The nature of the data dictates the method…

Insights on star-formation histories and physical properties of 1.2 ≤z ≲ 4 Herschel-detected galaxies

NASA Astrophysics Data System (ADS)

Sklias, P.; Schaerer, D.; Elbaz, D.; Pannella, M.; Schreiber, C.; Cava, A.

2017-09-01

Aims: We aim to test the impact of using variable star-forming histories (SFHs) and the IR luminosity as a constrain on the physical parameters of high redshift dusty star-forming galaxies. We explore in particular the properties (SFHs, ages, timescales) of galaxies depending on their belonging to the "main sequence" of star-forming galaxies (MS). Methods: We performed spectral energy distribution (SED) fitting of the UV-to-NIR and FIR emissions of a moderately large sample of GOODS-Herschel galaxies, for which rich multi-wavelength, optical to IR observations are available. We tested different SFHs and the impact of imposing energy conservation in the SED fitting process, to help with issues like the age-extinction degeneracy and produce SEDs consistent with observations. Results: Our simple models produce well constrained SEDs for the broad majority of the sample (84%), with the notable exception of the very high LIR end, for which we have indications that the energy conservation hypothesis cannot hold true for a single component population approach. We observe trends in the preferences in SFHs among our sources depending on stellar mass M⋆ and z. Trends also emerge in the characteristic timescales of the SED models depending on the location on the SFR - M⋆ diagram. We show that whilst using the same available observational data, we can produce galaxies less star-forming than classically inferred, if we allow rapidly declining SFHs, while properly reproducing their observables. These sources, representing 7% of the sample, can be post-starbursts undergoing quenching, and their SFRs are potentially overestimated if inferred from their LIR. Based on the trends observed in the rising SFH fits we explore a simple evolution model for stellar mass build-up over the considered time period. Conclusions: Our approach successfully breaks the age-extinction degeneracy, and enables to evaluate properly the SFRs of the sources in the SED fitting process. Fitting without the IR constrain leads to a strong preference for declining SFHs, while its inclusion increases the preference of rising SFHs, more so at high z, in tentative agreement with the cosmic star-formation history (CSFH), although this result suffers from poor statistics. Keeping in mind that the sample is biased toward high luminosities and intense star formation, the evolution shaped by our model appears as both bursty (in its early stages) and steady-lasting (later on). The SFH of the sample considered as a whole follows the CSFH with a surprisingly small scatter, and is compatible with other studies supporting that the more massive galaxies have built most of their mass earlier than lower mass galaxies.

Diazepam reduces excitability of amygdala and further influences auditory cortex following sodium salicylate treatment in rats.

PubMed

Song, Yu; Liu, Junxiu; Ma, Furong; Mao, Lanqun

2016-12-01

Diazepam can reduce the excitability of lateral amygdala and eventually suppress the excitability of the auditory cortex in rats following salicylate treatment, indicating the regulating effect of lateral amygdala to the auditory cortex in the tinnitus procedure. To study the spontaneous firing rates (SFR) of the auditory cortex and lateral amygdala regulated by diazepam in the tinnitus rat model induced by sodium salicylate. This study first created a tinnitus rat modal induced by sodium salicylate, and recorded SFR of both auditory cortex and lateral amygdala. Then diazepam was intraperitoneally injected and the SFR changes of lateral amygdala recorded. Finally, diazepam was microinjected on lateral amygdala and the SFR changes of the auditory cortex recorded. Both SFRs of the auditory cortex and lateral amygdala increased after salicylate treatment. SFR of lateral amygdala decreased after intraperitoneal injection of diazepam. Microinjecting diazepam to lateral amygdala decreased SFR of the auditory cortex ipsilaterally and contralaterally.

FY16 Status Report on NEAMS Neutronics Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, C. H.; Shemon, E. R.; Smith, M. A.

2016-09-30

The goal of the NEAMS neutronics effort is to develop a neutronics toolkit for use on sodium-cooled fast reactors (SFRs) which can be extended to other reactor types. The neutronics toolkit includes the high-fidelity deterministic neutron transport code PROTEUS and many supporting tools such as a cross section generation code MC 2-3, a cross section library generation code, alternative cross section generation tools, mesh generation and conversion utilities, and an automated regression test tool. The FY16 effort for NEAMS neutronics focused on supporting the release of the SHARP toolkit and existing and new users, continuing to develop PROTEUS functions necessarymore » for performance improvement as well as the SHARP release, verifying PROTEUS against available existing benchmark problems, and developing new benchmark problems as needed. The FY16 research effort was focused on further updates of PROTEUS-SN and PROTEUS-MOCEX and cross section generation capabilities as needed.« less

38 CFR 1.525 - Inspection of records by or disclosure of information to recognized representatives of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... or disclosure of information to recognized representatives of organizations and recognized attorneys... records by or disclosure of information to recognized representatives of organizations and recognized... recognized organization finds it necessary to call upon a local representative to assemble information or...

38 CFR 1.525 - Inspection of records by or disclosure of information to recognized representatives of...

Code of Federal Regulations, 2011 CFR

2011-07-01

... or disclosure of information to recognized representatives of organizations and recognized attorneys... records by or disclosure of information to recognized representatives of organizations and recognized... recognized organization finds it necessary to call upon a local representative to assemble information or...

38 CFR 1.525 - Inspection of records by or disclosure of information to recognized representatives of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... or disclosure of information to recognized representatives of organizations and recognized attorneys... records by or disclosure of information to recognized representatives of organizations and recognized... recognized organization finds it necessary to call upon a local representative to assemble information or...

38 CFR 1.525 - Inspection of records by or disclosure of information to recognized representatives of...

Code of Federal Regulations, 2012 CFR

2012-07-01

... or disclosure of information to recognized representatives of organizations and recognized attorneys... records by or disclosure of information to recognized representatives of organizations and recognized... recognized organization finds it necessary to call upon a local representative to assemble information or...

38 CFR 1.525 - Inspection of records by or disclosure of information to recognized representatives of...

Code of Federal Regulations, 2010 CFR

2010-07-01

... or disclosure of information to recognized representatives of organizations and recognized attorneys... records by or disclosure of information to recognized representatives of organizations and recognized... recognized organization finds it necessary to call upon a local representative to assemble information or...

46 CFR 31.10-1 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Recognized classification society-TB/ALL. 31.10-1 Section 31.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS INSPECTION AND CERTIFICATION Inspections § 31.10-1 Recognized classification society—TB/ALL. (a) In the inspection of hulls...

46 CFR 31.10-1 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Recognized classification society-TB/ALL. 31.10-1 Section 31.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS INSPECTION AND CERTIFICATION Inspections § 31.10-1 Recognized classification society—TB/ALL. (a) In the inspection of hulls...

46 CFR 31.10-1 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Recognized classification society-TB/ALL. 31.10-1 Section 31.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS INSPECTION AND CERTIFICATION Inspections § 31.10-1 Recognized classification society—TB/ALL. (a) In the inspection of hulls...

Neuropsychological status at seizure onset in children

PubMed Central

Fastenau, P S.; Johnson, C S.; Perkins, S M.; Byars, A W.; deGrauw, T J.; Austin, J K.; Dunn, D W.

2009-01-01

Objective: This large, prospective, community-based study characterized neuropsychological functioning and academic achievement at the time of the first recognized seizure and identified risk factors for cognitive deficits. Methods: We compared 282 children (ages 6–14 years, IQ ≥70) with a first recognized seizure to 147 healthy siblings on a battery of well-standardized and widely used neuropsychological and academic achievement tests and examined relationships with demographic and clinical variables. Results: In this intellectually normal cohort, 27% with just one seizure and up to 40% of those with risk factors exhibited neuropsychological deficits at or near onset. Risk factors associated with neuropsychological deficits included multiple seizures (i.e., second unprovoked seizure; odds ratio [OR] = 1.96), use of antiepileptic drugs (OR = 2.27), symptomatic/cryptogenic etiology (OR = 2.15), and epileptiform activity on the initial EEG (OR = 1.90); a child with all 4 risks is 3.00 times more likely than healthy siblings to experience neuropsychological deficits by the first clinic visit. Absence epilepsy carried increased odds for neuropsychological impairment (OR = 2.00). Conclusions: A subgroup of intellectually normal children with seizures showed neuropsychological deficits at onset. Academic achievement was unaffected, suggesting that there is a window early in the disorder for intervention to ameliorate the impact on school performance. Therefore, the risk factors identified here (especially if multiple risks are present) warrant swift referral for neuropsychological evaluation early in the course of the condition. GLOSSARY AED = antiepileptic drug; ANOVA = analysis of variance; CELF = Clinical Evaluation of Language Fundamentals; CI = confidence interval; CTOPP = Comprehensive Test of Phonological Processing; OR = odds ratio; PURS = prior unrecognized seizure; WCST = Wisconsin Card Sorting Test; WRAML = Wide Range Assessment of Memory and Learning. PMID:19675309

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

PubMed Central

Small, D; Levenstein, M; Kim, E; Carow, C; Amin, S; Rockwell, P; Witte, L; Burrow, C; Ratajczak, M Z; Gewirtz, A M

1994-01-01

We cloned the cDNA for stem cell tyrosine kinase 1 (STK-1), the human homolog of murine Flk-2/Flt-3, from a CD34+ hematopoietic stem cell-enriched library and investigated its expression in subsets of normal human bone marrow. The cDNA encodes a protein of 993 aa with 85% identity and 92% similarity to Flk-2/Flt-3. STK-1 is a member of the type III receptor tyrosine kinase family that includes KIT (steel factor receptor), FMS (colony-stimulating factor 1R), and platelet-derived growth factor receptor. STK-1 expression in human blood and marrow is restricted to CD34+ cells, a population greatly enriched for stem/progenitor cells. Anti-STK-1 antiserum recognizes polypeptides of 160 and 130 kDa in several STK-1-expressing cell lines and in 3T3 cells transfected with a STK-1 expression vector. Antisense oligonucleotides directed against STK-1 sequences inhibited hematopoietic colony formation, most strongly in long-term bone marrow cultures. These data suggest that STK-1 may function as a growth factor receptor on hematopoietic stem and/or progenitor cells. Images Fig. 2 Fig. 3 Fig. 4 PMID:7507245

An Outbreak of Diarrhea in Mandera, Kenya, Due to Escherichia coli Serogroup O-Nontypable Strain That Had a Coding Gene for Enteroaggregative E. coli Heat-Stable Enterotoxin 1

PubMed Central

Ochi, Sadayuki; Shah, Mohammad; Odoyo, Erick; Bundi, Martin; Miringu, Gabriel; Guyo, Sora; Wandera, Ernest; Kathiiko, Cyrus; Kariuki, Samuel; Karama, Mohamed; Tsuji, Takao; Ichinose, Yoshio

2017-01-01

In an outbreak of gastroenteritis in December 2009, in Mandera, Kenya, Escherichia coli O-nontypable (ONT) strain was isolated from stool specimens of patients (18/24, 75%). The E. coli ONT organisms could not be assigned to any of the recognized diarrheagenic groups of E. coli. However, they possessed the enteroaggregative E. coli heat-stable enterotoxin-1 gene. The cell-free culture filtrates of the E. coli ONT strain isolated from the outbreak cases induced considerable amount of fluid accumulation in suckling mouse intestine, indicating production of an enterotoxic factor(s). These results identify E. coli that did not have any diarrheagenic characteristics except astA as the etiological agent of the diarrheal outbreak in Mandera. It is however considered necessary to characterize the fluid accumulation factor(s) to determine whether any novel toxins were responsible for the fluid accumulation. Moreover, it is important to study dissemination of strains producing the enterotoxic factor(s) to assess their public health significance distribution in the environment. PMID:27994101

Excellence in Business Education (A "FRUCE" Model for Higher Education Commission-Recognized Business Schools in Pakistan)

ERIC Educational Resources Information Center

Kolachi, Nadir Ali; Mohammad, Jan

2013-01-01

The paper develops a new model of the essential factors required to be a top business school in the world for the benefit of schools recognized by the Higher Education Commission (HEC) in Pakistan. Globally, top business schools are those that excel in research, attract strong faculty, and successfully foster student development. The present…

Harbingers of the Caliphate: Islamic State Revolutionary Actions 2011-2014

DTIC Science & Technology

2016-06-01

movements and tribal organizations. This evaluation illuminates the Islamic State’s internal structure and methodology for governing territory to support...and tribal organizations. This evaluation illuminates the Islamic State’s internal structure and methodology for governing territory to support...schools of thought: Theories that recognize structural conditions as the seminal factor leading to revolution, and those that recognize actors and

Individual Differences in Incorrect Responding and the Ability to Discriminate the Source of the Products of Retrieval

ERIC Educational Resources Information Center

Jonker, Tanya R.

2016-01-01

When memory is tested, researchers are often interested in the items that were correctly recalled or recognized, while ignoring or factoring out trials where one "recalls" or "recognizes" a nonstudied item. However, intrusions and false alarms are more than nuisance data and can provide key insights into the memory system. The…

How adolescent girls interpret weight-loss advertising.

PubMed

Hobbs, Renee; Broder, Sharon; Pope, Holly; Rowe, Jonelle

2006-10-01

While they demonstrate some ability to critically analyze the more obvious forms of deceptive weight-loss advertising, many girls do not recognize how advertising evokes emotional responses or how visual and narrative techniques are used to increase identification in weight-loss advertising. This study examined how girls aged 9-17 years interpreted magazine advertising, television (TV) advertising and infomercials for weight-loss products in order to determine whether deceptive advertising techniques were recognized and to assess pre-existing media-literacy skills. A total of 42 participants were interviewed in seven geographic regions of the United States. In groups of three, participants were shown seven print and TV advertisements (ads) for weight-loss products and asked to share their interpretations of each ad. Common factors in girls' interpretation of weight-loss advertising included responding to texts emotionally by identifying with characters; comparing and contrasting persuasive messages with real-life experiences with family members; using prior knowledge about nutrition management and recognizing obvious deceptive claims like 'rapid' or 'permanent' weight loss. Girls were less able to demonstrate skills including recognizing persuasive construction strategies including message purpose, target audience and subtext and awareness of economic factors including financial motives, credibility enhancement and branding.

Integral field spectroscopy of nearby quasi-stellar objects - II. Molecular gas content and conditions for star formation

NASA Astrophysics Data System (ADS)

Husemann, B.; Davis, T. A.; Jahnke, K.; Dannerbauer, H.; Urrutia, T.; Hodge, J.

2017-09-01

We present single-dish 12CO(1-0) and 12CO(2-1) observations for 14 low-redshift quasi-stellar objects (QSOs). In combination with optical integral field spectroscopy, we study how the cold gas content relates to the star formation rate (SFR) and black hole accretion rate. 12CO(1-0) is detected in 8 of 14 targets and 12CO(2-1) is detected in 7 out of 11 cases. The majority of disc-dominated QSOs reveal gas fractions and depletion times matching normal star-forming systems. Two gas-rich major mergers show clear starburst signatures with higher than average gas fractions and shorter depletion times. Bulge-dominated QSO hosts are mainly undetected in 12CO(1-0), which corresponds, on average, to lower gas fractions than in disc-dominated counterparts. Their SFRs, however, imply shorter than average depletion times and higher star formation efficiencies. Negative QSO feedback through removal of cold gas seems to play a negligible role in our sample. We find a trend between black hole accretion rate and total molecular gas content for disc-dominated QSOs when combined with literature samples. We interpret this as an upper envelope for the nuclear activity and it is well represented by a scaling relation between the total and circumnuclear gas reservoir accessible for accretion. Bulge-dominated QSOs significantly differ from that scaling relation and appear uncorrelated with the total molecular gas content. This could be explained either by a more compact gas reservoir, blown out of the gas envelope through outflows, or a different interstellar medium phase composition.

The FMOS-COSMOS survey of star-forming galaxies at z ∼ 1.6. II. The mass-metallicity relation and the dependence on star formation rate and dust extinction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zahid, H. J.; Sanders, D. B.; Chu, J.

We investigate the relationships between stellar mass, gas-phase oxygen abundance (metallicity), star formation rate (SFR), and dust content of star-forming galaxies at z ∼ 1.6 using Subaru/FMOS spectroscopy in the COSMOS field. The mass-metallicity (MZ) relation at z ∼ 1.6 is steeper than the relation observed in the local universe. The steeper MZ relation at z ∼ 1.6 is mainly due to evolution in the stellar mass where the MZ relation begins to turnover and flatten. This turnover mass is 1.2 dex larger at z ∼ 1.6. The most massive galaxies at z ∼ 1.6 (∼10{sup 11} M {sub ☉})more » are enriched to the level observed in massive galaxies in the local universe. The MZ relation we measure at z ∼ 1.6 supports the suggestion of an empirical upper metallicity limit that does not significantly evolve with redshift. We find an anti-correlation between metallicity and SFR for galaxies at a fixed stellar mass at z ∼ 1.6, which is similar to trends observed in the local universe. We do not find a relation between stellar mass, metallicity, and SFR that is independent of redshift; rather, our data suggest that there is redshift evolution in this relation. We examine the relation between stellar mass, metallicity, and dust extinction, and find that at a fixed stellar mass, dustier galaxies tend to be more metal rich. From examination of the stellar masses, metallicities, SFRs, and dust extinctions, we conclude that stellar mass is most closely related to dust extinction.« less

Bulgeless galaxies in the COSMOS field: environment and star formation evolution at z < 1

NASA Astrophysics Data System (ADS)

Grossi, Marco; Fernandes, Cristina A. C.; Sobral, David; Afonso, José; Telles, Eduardo; Bizzocchi, Luca; Paulino-Afonso, Ana; Matute, Israel

2018-03-01

Combining the catalogue of galaxy morphologies in the COSMOS field and the sample of H α emitters at redshifts z = 0.4 and z = 0.84 of the HiZELS survey, we selected ˜ 220 star-forming bulgeless systems (Sérsic index n ≤ 1.5) at both epochs. We present their star formation properties and we investigate their contribution to the star formation rate function (SFRF) and global star formation rate density (SFRD) at z < 1. For comparison, we also analyse H α emitters with more structurally evolved morphologies that we split into two classes according to their Sérsic index n: intermediate (1.5 < n ≤ 3) and bulge-dominated (n > 3). At both redshifts, the SFRF is dominated by the contribution of bulgeless galaxies and we show that they account for more than 60 per cent of the cosmic SFRD at z < 1. The decrease of the SFRD with redshift is common to the three morphological types, but it is stronger for bulge-dominated systems. Star-forming bulgeless systems are mostly located in regions of low to intermediate galaxy densities (Σ ˜ 1-4 Mpc-2) typical of field-like and filament-like environments and their specific star formation rates (sSFRs) do not appear to vary strongly with local galaxy density. Only few bulgeless galaxies in our sample have high (sSFR > 10-9 yr-1) and these are mainly low-mass systems. Above M* ˜ 1010 M⊙ bulgeless are evolving at a `normal' rate (10-9 yr-1 < sSFR < 10-10 yr-1) and in the absence of an external trigger (i.e. mergers/strong interactions) they might not be able to develop a central classical bulge.

The Human Splicing Factor ASF/SF2 can Specifically Recognize Pre-mRNA 5' Splice Sites

NASA Astrophysics Data System (ADS)

Zuo, Ping; Manley, James L.

1994-04-01

ASF/SF2 is a human protein previously shown to function in in vitro pre-mRNA splicing as an essential factor necessary for all splices and also as an alternative splicing factor, capable of switching selection of 5' splice sites. To begin to study the protein's mechanism of action, we have investigated the RNA binding properties of purified recombinant ASF/SF2. Using UV crosslinking and gel shift assays, we demonstrate that the RNA binding region of ASF/SF2 can interact with RNA in a sequence-specific manner, recognizing the 5' splice site in each of two different pre-mRNAs. Point mutations in the 5' splice site consensus can reduce binding by as much as a factor of 100, with the largest effects observed in competition assays. These findings support a model in which ASF/SF2 aids in the recognition of pre-mRNA 5' splice sites.

Expression of the pituitary transcription factor Ptx-1, but not that of the trans-activating factor prop-1, is reduced in human corticotroph adenomas and is associated with decreased alpha-subunit secretion.

PubMed

Skelly, R H; Korbonits, M; Grossman, A; Besser, G M; Monson, J P; Geddes, J F; Burrin, J M

2000-07-01

We have studied the expression of the pituitary transcription factors Ptx-1 and Prop-1 in a series of 34 pituitary adenomas fully characterized for in vitro hormone secretion and histological staining. In studies involving mammalian cell lines, the pituitary transcription factor Ptx-1 has been shown to be a pituitary hormone panactivator, whereas more recent studies have shown that it plays an important role in alpha-subunit gene expression. Its expression has not been examined previously in human pituitary adenomas characterized by in vitro hormone secretory profiles. Of the 34 pituitary adenomas studied, Ptx-1 expression was reduced by more than 50% compared to that of the housekeeping gene human glyceraldehyde-3-phosphate dehydrogenase in the 6 corticotroph adenomas, which also had significantly reduced alpha-subunit production (all 6 tumors secreting < or =0.5 ng/24 h). Mutations of the pituitary transcription factor Prop-1, which is responsible for the syndrome of Ames dwarfism in mice, are being increasingly recognized as a cause of combined pituitary hormone deficiency in humans, although ACTH deficiency has been described only once. Prop-1 expression was detected in all 34 pituitary adenomas, including 6 corticotroph adenomas and 5 gonadotroph adenomas. The expression of Prop-1 has not been described previously in these cell phenotypes.

The Importance of TLR2 and Macrophages in Modulating a Humoral Response after Encountering Streptococcus pneumoniae

DTIC Science & Technology

2008-03-26

Response after Encountering Streptococcus Pneumoniae" Brian Schae:5 ,Ph.D. Department of Microbi ogy & Immunology Committee Chairperson Masters...presenting cells (APCs), such as macrophages (M ) and dendritic cells (DC) recognize microbial surface components via cell surface receptors (i.e...stimulating factor (GM-CSF). TH1 cells are able to secrete IFN- , which is important in activating M to produce mediators important for microbial

A Study to Develop an Army Medical Department Wellness Program

DTIC Science & Technology

1982-08-01

fill in between meals, or to put the finishing touches on your meals and snacks. SLE i14: Artificially sweetened gelatin or i:w-calorie puddings are good...to factors such as sex, age, cigarette smoking habits, high blood pressure, high blood-sugar content ( diabetes ), electrocardio- gram abnormalities...hypertension, diabetes mellitus, and other disorders.1 3 Yet, most organizations have failed to recognize stress as a problem or to institute plans to assist

Quality in School Environments: A Multiple Case Study of the Diagnosis, Design and Management of Environmental Quality in Five Elementary Schools in the Baltimore City Public Schools from an Action Research Perspective. Volumes I and II.

ERIC Educational Resources Information Center

Lackney, Jeffery A.

Environmental factors are being increasingly recognized as playing a role in school effectiveness and educational outcomes. Volume 1 examines what is known concerning the diagnosis, design, and management of environmental quality in schools, and the perceived relationship between environmental quality and educational outcomes, as revealed in an…

Acceleration of thrombosis and hemolysis by fibrinolysis inhibiting factor and suppression by Ia antigen expressed on T cells in partially hepatectomized Lewis rats.

PubMed

Nakatsuji, T

1996-10-01

Partial hepatectomy (PH) of a left lateral lobe was performed on 45 Lewis rats 6.5-8.0 weeks old. Splenectomy, the injection of a fibrinolysis inhibiting (F1) factor (Gly-Pro-Arg-Pro) and both treatments were combined with the PH in 10, 11 and 9 rats, respectively. Among them, 4 males became weak with marked atrophic thymus before the 46th day after PH. All these males had massive pulmonary necrosis accompanied by platelet-rich emboli. Erythrocyte rosette formation was recognized in the mesenteric lymph nodes (MLN) of all 4 rats. The rosette erythrocytes reacted to anti-macrophage antibodies. FI factor-induced acute immune hemolysis occurred 5-9 days after PH in the 2 of the FI factor-injected and splenectomized males. Mildly to moderately atrophic thymuses were found in almost all the rats followed for 156-177 days after PH. T lymphocytes with cytoplasmic dense polysomes and desquamating endothelial cells with phagocytic erythrocytes were observed in the thymic electron micrograph of the FI factor-injected female. Positive D-D dimers were measured in the plasma of 7 rats. Increased peripheral reticulocytes (7.0 +/- 0.4%) were recognized in the males 156 days after single PH but not in the females. Ten of the 24 females and 3 of the 16 males showed an increase of peripheral Ia+ T cells to 20-30%. As well as acute pulmonary emboli, autoimmune hemolysis was induced more actively after PH in the males with CD5+ T cells that expressed the Ia antigen weakly.

Effectiveness of interventions to provide culturally appropriate maternity care in increasing uptake of skilled maternity care: a systematic review

PubMed Central

Coast, Ernestina; Jones, Eleri; Lattof, Samantha R; Portela, Anayda

2016-01-01

Addressing cultural factors that affect uptake of skilled maternity care is recognized as an important step in improving maternal and newborn health. This article describes a systematic review to examine the evidence available on the effects of interventions to provide culturally appropriate maternity care on the use of skilled maternity care during pregnancy, for birth or in the postpartum period. Items published in English, French and/or Spanish between 1 January 1990 and 31 March 2014 were considered. Fifteen studies describing a range of interventions met the inclusion criteria. Data were extracted on population and intervention characteristics; study design; definitions and data for relevant outcomes; and the contexts and conditions in which interventions occurred. Because most of the included studies focus on antenatal care outcomes, evidence of impact is particularly limited for care seeking for birth and after birth. Evidence in this review is clustered within a small number of countries, and evidence from low- and middle-income countries is notably lacking. Interventions largely had positive effects on uptake of skilled maternity care. Cultural factors are often not the sole factor affecting populations’ use of maternity care services. Broader social, economic, geographical and political factors interacted with cultural factors to affect targeted populations’ access to services in included studies. Programmes and policies should seek to establish an enabling environment and support respectful dialogue with communities to improve use of skilled maternity care. Whilst issues of culture are being recognized by programmes and researchers as being important, interventions that explicitly incorporate issues of culture are rarely evaluated. PMID:27190222

Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling.

PubMed

Farquharson, Colin; Ahmed, S Faisal

2013-04-01

Linear bone growth is widely recognized to be adversely affected in children with chronic kidney disease (CKD) and other chronic inflammatory disorders. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is anabolic to the skeleton and inflammatory cytokines compromise bone growth through a number of different mechanisms, which include interference with the systemic as well as the tissue-level GH/IGF-1 axis. Despite attempts to promote growth and control disease, there are an increasing number of reports of the persistence of poor growth in a substantial proportion of patients receiving rhGH and/or drugs that block cytokine action. Thus, there is an urgent need to consider better and alternative forms of therapy that are directed specifically at the mechanism of the insult which leads to abnormal bone health. Suppressor of cytokine signaling 2 (SOCS2) expression is increased in inflammatory conditions including CKD, and is a recognized inhibitor of GH signaling. Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter.

PubMed

Isalan, M; Klug, A; Choo, Y

2001-07-01

DNA-binding domains with predetermined sequence specificity are engineered by selection of zinc finger modules using phage display, allowing the construction of customized transcription factors. Despite remarkable progress in this field, the available protein-engineering methods are deficient in many respects, thus hampering the applicability of the technique. Here we present a rapid and convenient method that can be used to design zinc finger proteins against a variety of DNA-binding sites. This is based on a pair of pre-made zinc finger phage-display libraries, which are used in parallel to select two DNA-binding domains each of which recognizes given 5 base pair sequences, and whose products are recombined to produce a single protein that recognizes a composite (9 base pair) site of predefined sequence. Engineering using this system can be completed in less than two weeks and yields proteins that bind sequence-specifically to DNA with Kd values in the nanomolar range. To illustrate the technique, we have selected seven different proteins to bind various regions of the human immunodeficiency virus 1 (HIV-1) promoter.

Knowledge of heart attack symptoms and risk factors among native Thais: a street-intercept survey method.

PubMed

Poomsrikaew, Ornwanya; Ryan, Catherine J; Zerwic, Julie J

2010-10-01

This study aimed to determine Thais' knowledge of heart attack symptoms and risk factors and whether that knowledge was related to age, gender or education. Via a street-intercept survey method, a convenience sample of people aged ≥ 35 years (n = 192) was recruited. Mean age was 47 ± 9.6 years (range 35-81), and 55.2% were female. Participants identified on average 5.6 of 9 heart attack symptoms (SD 1.8) and 5.3 of 8 heart attack risk factors (SD 2.1). However, 66.7% mistakenly thought the chest discomfort would be severe, sharp and stabbing, and many subjects erroneously selected symptoms that are actually stroke symptoms. There were no gender or educational differences in knowledge of heart attack symptoms and risk factors. Older adults recognized fewer total symptoms than did younger adults. These findings could direct health-care providers to help the Thai population differentiate symptoms of heart attack from stroke. © 2010 Blackwell Publishing Asia Pty Ltd.

The optimal minimally invasive percutaneous nephrolithotomy strategy for the treatment of staghorn stones in a solitary kidney.

PubMed

Liu, Chenli; Cui, Zelin; Zeng, Guohua; Wan, Shaw P; Li, Jiasheng; Zhu, Wei; Zeng, Tao; Liu, Yang

2016-04-01

The objective of the study was to analyze the treatment outcomes for staghorn stones in patients with solitary kidney using either the single-tract or the multi-tract minimally invasive percutaneous nephrolithotomy (MPCNL). We retrospectively reviewed 105 patients who underwent MPCNL for staghorn calculi in solitary kidney from 2012 to 2014. The patients who underwent the single-tract approach (71 patients) were assigned to Group 1. The 34 patients who underwent the multi-tract approach (34 patients) were assigned to Group 2. We recorded and compared the patient's demographics, intraoperative parameters, and post-operative outcomes. We also analyzed any complications as a result of the particular procedure, as well as any resulting stone-free rates (SFRs). The mean number of access tracts was 2.38 ± 0.70 (range 2-4) for Group 2. The mean operative time was longer for Group 2, p = 0.01. The initial SFR was 52.1% for Group 1 and 47.1% for Group 2 after the one-session procedure, p = 0.63.The final SFR improved to 83.1 and 79.4% for both groups following auxiliary treatment, p = 0.65. The mean hemoglobin drop was higher in Group 2 as compared to Group 1, p < 0.01. There was no significant difference in the change of mean serum creatinine in either group. There were fewer overall complications in Group 1 than in Group 2 (23.9 vs. 44.1%). Almost half of the patients who underwent multi-tract MPCNL required an additional procedure to achieve satisfactory stone clearance. The results showed that single-tract MPCNL might be a better treatment option for staghorn stones in a solitary kidney with the same therapeutic outcome, but with less complications.

Comparison of treatment outcomes according to output voltage during shockwave lithotripsy for ureteral calculi: a prospective randomized multicenter study.

PubMed

Park, Jinsung; Kim, Hong-Wook; Hong, Sungwoo; Yang, Hee Jo; Chung, Hong

2015-05-01

To investigate the effect of fixed versus escalating voltage during SWL on treatment outcomes in patients with ureteral calculi (UC). A prospective, randomized, multicenter trial was conducted on 120 patients who were diagnosed with a single radiopaque UC. The patients were randomized into group C (n = 60, constant 13 kV, 3,000 shock wave, 2 Hz) or group E (n = 60, 11.4-12.0-13 kV per 1,000 shock waves, 2 Hz). They were evaluated by plain abdominal radiography and urinalysis at 1 week after a single session of SWL, and repeat SWL was performed if needed. The primary endpoint was stone-free rate at 1 week (SFR1) after SWL. Secondary endpoints were post-SWL visual pain score (VPS), oral analgesic requirements during 1 week, and cumulative SFRs after the second and third sessions of SWL. Groups C and E were well balanced in terms of baseline patients and stone characteristics, including pre-SWL VPS, stone location, and stone size (6.24 ± 1.92 vs. 6.30 ± 2.13 mm). SFR1s were not significantly different between groups C and E (60.0 vs. 68.3%, p = 0.447). Analyses stratified by stone size (<6 vs. ≥6 mm) showed no difference in SFR1 (p = 0.148 vs. 0.808). In the analyses stratified by stone location, group E tended to be more effective in distal UC (81.0 vs. 50.0%, p = 0.052), whereas no difference was seen in proximal UC (p = 0.487). Secondary endpoints were also similar between the two groups. Our results suggest that voltage escalation during SWL in UC may not provide superior stone fragmentation compared to fixed voltage.

T wave abnormalities, high body mass index, current smoking and high lipoprotein (a) levels predict the development of major abnormal Q/QS patterns 20 years later. A population-based study

PubMed Central

Moller, Christina Strom; Byberg, Liisa; Sundstrom, Johan; Lind, Lars

2006-01-01

Background Most studies on risk factors for development of coronary heart disease (CHD) have been based on the clinical outcome of CHD. Our aim was to identify factors that could predict the development of ECG markers of CHD, such as abnormal Q/QS patterns, ST segment depression and T wave abnormalities, in 70-year-old men, irrespective of clinical outcome. Methods Predictors for development of different ECG abnormalities were identified in a population-based study using stepwise logistic regression. Anthropometrical and metabolic factors, ECG abnormalities and vital signs from a health survey of men at age 50 were related to ECG abnormalities identified in the same cohort 20 years later. Results At the age of 70, 9% had developed a major abnormal Q/QS pattern, but 63% of these subjects had not been previously hospitalized due to MI, while 57% with symptomatic MI between age 50 and 70 had no major Q/QS pattern at age 70. T wave abnormalities (Odds ratio 3.11, 95% CI 1.18–8.17), high lipoprotein (a) levels, high body mass index (BMI) and smoking were identified as significant independent predictors for the development of abnormal major Q/QS patterns. T wave abnormalities and high fasting glucose levels were significant independent predictors for the development of ST segment depression without abnormal Q/QS pattern. Conclusion T wave abnormalities on resting ECG should be given special attention and correlated with clinical information. Risk factors for major Q/QS patterns need not be the same as traditional risk factors for clinically recognized CHD. High lipoprotein (a) levels may be a stronger risk factor for silent myocardial infarction (MI) compared to clinically recognized MI. PMID:16519804

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

PubMed Central

Shi, Yuan; Chen, Xiang; Elsasser, Suzanne; Stocks, Bradley B.; Tian, Geng; Lee, Byung-Hoon; Shi, Yanhong; Zhang, Naixia; de Poot, Stefanie A. H.; Tuebing, Fabian; Sun, Shuangwu; Vannoy, Jacob; Tarasov, Sergey G.; Engen, John R.; Finley, Daniel; Walters, Kylie J.

2016-01-01

Structured Abstract INTRODUCTION The ubiquitin-proteasome system comprises hundreds of distinct pathways of degradation, which converge at the step of ubiquitin recognition by the proteasome. Five proteasomal ubiquitin receptors have been identified, two that are intrinsic to the proteasome (Rpn10 and Rpn13) and three reversibly associated proteasomal ubiquitin receptors (Rad23, Dsk2, and Ddi1). RATIONALE We found that the five known proteasomal ubiquitin receptors of yeast are collectively nonessential for ubiquitin recognition by the proteasome. We therefore screened for additional ubiquitin receptors in the proteasome and identified subunit Rpn1 as a candidate. We used nuclear magnetic resonance (NMR) spectroscopy to characterize the structure of the binding site within Rpn1, which we term the T1 site. Mutational analysis of this site showed its functional importance within the context of intact proteasomes. T1 binds both ubiquitin and ubiquitin-like (UBL) proteins, in particular the substrate-delivering shuttle factor Rad23. A second site within the Rpn1 toroid, T2, recognizes the UBL domain of deubiquitinating enzyme Ubp6, as determined by hydrogen-deuterium exchange mass spectrometry analysis and validated by amino acid substitution and functional assays. The Rpn1 toroid thus serves a critical scaffolding role within the proteasome, helping to assemble multiple proteasome cofactors as well as substrates. RESULTS Our results indicate that proteasome subunit Rpn1 can recognize both ubiquitin and UBL domains of substrate shuttling factors that themselves bind ubiquitin and function as reversibly-associated proteasomal ubiquitin receptors. Recognition is mediated by the T1 site within the Rpn1 toroid, which supports proteasome function in vivo. We found that the capacity of T1 to recognize both ubiquitin and UBL proteins was shared with Rpn10 and Rpn13. The surprising multiplicity of ubiquitin-recognition domains within the proteasome may promote enhanced, multipoint binding of ubiquitin chains. The structures of the T1 site in its free state and complexed with monoubiquitin or K48-linked diubiquitin were solved, revealing that three neighboring outer helices from the T1 toroid engage two ubiquitins. This binding mode leads to a preference for certain ubiquitin chain types, especially K6- and K48-linked chains, in a distinct configuration that can position substrates close to the entry port of the proteasome. The fate of proteasome-docked ubiquitin conjugates is determined by a competition between deubiquitination and substrate degradation. We find that proximal to the T1 site within the Rpn1 toroid is a second UBL-binding site, T2, that does not assist in ubiquitin chain recognition, but rather in chain disassembly, by binding to the UBL domain of deubiquitinating enzyme Ubp6. Importantly, the UBL interactors at T1 and T2 are distinct, assigning substrate localization to T1 and substrate deubiquitination to T2. CONCLUSION A ligand-binding hotspot was identified in the Rpn1 toroid, consisting of two adjacent receptor sites, T1 and T2. The Rpn1 toroid represents a novel class of binding domains for ubiquitin and UBL proteins. This study thus defines a novel two-site recognition domain intrinsic to the proteasome that uses homologous ubiquitin/UBL-class ligands to assemble substrates, substrate shuttling factors, and a deubiquitinating enzyme in close proximity. A ligand-binding hotspot in the proteasome for assembling substrates and cofactors Schematic (top) and model structure (bottom, left) mapping the UBL-binding Rpn1 T1 (indigo) and T2 (orange) sites. (Bottom, right) Enlarged region of the proteasome to illustrate the Rpn1 T1 and T2 sites bound to a ubiquitin chain (yellow) and deubiquitinating enzyme Ubp6 (green), respectively. PDB 4CR2 and 2B9R were used for this figure. Hundreds of pathways for degradation converge at ubiquitin recognition by proteasome. Here we found that the five known proteasomal ubiquitin receptors are collectively nonessential for ubiquitin recognition, and identified a sixth receptor, Rpn1. A site (T1) in the Rpn1 toroid recognized ubiquitin and ubiquitin-like (UBL) domains of substrate shuttling factors. T1 structures with monoubiquitin or K48 diubiquitin show three neighboring outer helices engaging two ubiquitins. T1 contributes a distinct substrate-binding pathway with preference for K48-linked chains. Proximal to T1 within the Rpn1 toroid is a second UBL-binding site (T2) that assists in ubiquitin chain disassembly, by binding the UBL of deubiquitinating enzyme Ubp6. Thus a two-site recognition domain intrinsic to the proteasome uses homologous ubiquitin/UBL-class ligands to assemble substrates, shuttling factors, and a deubiquitinating enzyme. PMID:26912900

Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor.

PubMed

Hegenauer, Volker; Fürst, Ursula; Kaiser, Bettina; Smoker, Matthew; Zipfel, Cyril; Felix, Georg; Stahl, Mark; Albert, Markus

2016-07-29

Parasitic plants are a constraint on agriculture worldwide. Cuscuta reflexa is a stem holoparasite that infests most dicotyledonous plants. One exception is tomato, which is resistant to C. reflexa We discovered that tomato responds to a small peptide factor occurring in Cuscuta spp. with immune responses typically activated after perception of microbe-associated molecular patterns. We identified the cell surface receptor-like protein CUSCUTA RECEPTOR 1 (CuRe1) as essential for the perception of this parasite-associated molecular pattern. CuRe1 is sufficient to confer responsiveness to the Cuscuta factor and increased resistance to parasitic C. reflexa when heterologously expressed in otherwise susceptible host plants. Our findings reveal that plants recognize parasitic plants in a manner similar to perception of microbial pathogens. Copyright © 2016, American Association for the Advancement of Science.

Monocytic cell junction proteins serve important roles in atherosclerosis via the endoglin pathway

PubMed Central

Chen, Lina; Chen, Zhongliang; Ge, Menghua; Tang, Oushan; Cheng, Yinhong; Zhou, Haoliang; Shen, Yu; Qin, Fengming

2017-01-01

The formation of atherosclerosis is recognized to be caused by multiple factors including pathogenesis in monocytes during inflammation. The current study provided evidence that monocytic junctions were significantly altered in patients with atherosclerosis, which suggested an association between cell junctions and atherosclerosis. Claudin-1, occludin-1 and ZO-1 were significantly enhanced in atherosclerosis, indicating that the tight junction pathway was activated during the pathogenesis of atherosclerosis. In addition, the gene expression of 5 connexin members involved in the gap junction pathway were quantified, indicating that connexin 43 and 46 were significantly up-regulated in atherosclerosis. Furthermore, inflammatory factors including endoglin and SMAD were observed, suggesting that immune regulative factors were down-regulated in this pathway. Silicon-based analysis additionally identified that connexins and tight junctions were altered in association with monocytic inflammation regulations, endoglin pathway. The results imply that reduced expression of the immune regulation pathway in monocytes is correlated with the generation of gap junctions and tight junctions which serve important roles in atherosclerosis. PMID:28901429

White adipose tissue and cardiovascular disease.

PubMed

Matsuzawa, Yuji

2005-12-01

Adipocytes have recently been shown to secrete a variety of bioactive substances called 'adipocytokines', and have been recognized as endocrine cells. Tumour necrosis factor (TNF)-alphaalpha, plasminogen activator inhibitor-1 (PAI-1) and heparin-binding epidermal-growth-factor-like growth factor (HBEGF) are among these adipocytokines, and they contribute to the development of vascular diseases. Visfatin is a visceral fat-specific protein that may be related to the development of obesity-related diseases such as diabetes mellitus and cardiovascular disease. In contrast, adiponectin, an adipose-tissue-specific collagen-like protein, has recently been reported as an important anti-atherogenic and anti-diabetic protein. Adipocytokine secretion may be regulated dynamically by the nutritional state. Visceral fat accumulation leads to dysfunction of adipocytes (including hypersecretion of TNF-alphaalpha, PAI-1 and HBEGF, and hyposecretion of adiponectin), which results in the development of a variety of metabolic and circulatory diseases. In this review, the importance of adipocytokines, including adiponectin, is discussed with respect to cardiovascular disease.

17 CFR 240.17g-1 - Application for registration as a nationally recognized statistical rating organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... as a nationally recognized statistical rating organization. 240.17g-1 Section 240.17g-1 Commodity and... Statistical Rating Organizations § 240.17g-1 Application for registration as a nationally recognized statistical rating organization. (a) Initial application. A credit rating agency applying to the Commission to...

17 CFR 240.17g-1 - Application for registration as a nationally recognized statistical rating organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... as a nationally recognized statistical rating organization. 240.17g-1 Section 240.17g-1 Commodity and... Statistical Rating Organizations § 240.17g-1 Application for registration as a nationally recognized statistical rating organization. (a) Initial application. A credit rating agency applying to the Commission to...

Improving entrepreneurial opportunity recognition through web content analytics

NASA Astrophysics Data System (ADS)

Bakar, Muhamad Shahbani Abu; Azmi, Azwiyati

2017-10-01

The ability to recognize and develop an opportunity into a venture defines an entrepreneur. Research in opportunity recognition has been robust and focuses more on explaining the processes involved in opportunity recognition. Factors such as prior knowledge, cognitive and creative capabilities are shown to affect opportunity recognition in entrepreneurs. Prior knowledge in areas such as customer problems, ways to serve the market, and technology has been shows in various studies to be a factor that facilitates entrepreneurs to identify and recognize opportunities. Findings from research also shows that experienced entrepreneurs search and scan for information to discover opportunities. Searching and scanning for information has also been shown to help novice entrepreneurs who lack prior knowledge to narrow this gap and enable them to better identify and recognize opportunities. There is less focus in research on finding empirically proven techniques and methods to develop and enhance opportunity recognition in student entrepreneurs. This is important as the country pushes for more graduate entrepreneurs that can drive the economy. This paper aims to discuss Opportunity Recognition Support System (ORSS), an information support system to help especially student entrepreneurs in identifying and recognizing business opportunities. The ORSS aims to provide the necessary knowledge to student entrepreneurs to be able to better identify and recognize opportunities. Applying design research, theories in opportunity recognition are applied to identify the requirements for the support system and the requirements in turn dictate the design of the support system. The paper proposes the use of web content mining and analytics as two core components and techniques for the support system. Web content mining can mine the vast knowledge repositories available on the internet and analytics can provide entrepreneurs with further insights into the information needed to recognize opportunities in a given market or industry.

Associations between informal care, disease, and risk factors: A Spanish country-wide population-based study.

PubMed

González-de Paz, Luís; Real, Jordi; Borrás-Santos, Alicia; Martínez-Sánchez, José M; Rodrigo-Baños, Virginia; Dolores Navarro-Rubio, María

2016-05-01

This population-based study using 2011-2012 Spanish National Health Survey data aimed to measure the impact of disease, health-related habits, and risk factors associated with informal caregiving. We included and matched self-reported informal caregivers [ICs] with controls (1:4) from the same survey. For each outcome, we analyzed associations between ICs and controls using linear regression or logistic regression models. ICs had 3.4 per cent more depression (OR: 1.33, 95 per cent confidence intervals [CI]:1.06, 1.68). ICs had lower social support (95 per cent CI: 1.64, 3.28), they did more housework alone (OR:3.6, 95 per cent CI:2.65, 4.89), and had greater stress (95 per cent CI:0.13, 0.83). Women ICs caring alone had more anxiety than other groups. We found no statistical association between caregivers and worse health-related habits or increased risk factors (less physical activity, smoking, drinking, and cholesterol). Our results provide evidence that health-care professionals and organizations should recognize the importance of caring for those who care.

A Novel WRKY transcription factor is required for induction of PR-1a gene expression by salicylic acid and bacterial elicitors.

PubMed

van Verk, Marcel C; Pappaioannou, Dimitri; Neeleman, Lyda; Bol, John F; Linthorst, Huub J M

2008-04-01

PR-1a is a salicylic acid-inducible defense gene of tobacco (Nicotiana tabacum). One-hybrid screens identified a novel tobacco WRKY transcription factor (NtWRKY12) with specific binding sites in the PR-1a promoter at positions -564 (box WK(1)) and -859 (box WK(2)). NtWRKY12 belongs to the class of transcription factors in which the WRKY sequence is followed by a GKK rather than a GQK sequence. The binding sequence of NtWRKY12 (WK box TTTTCCAC) deviated significantly from the consensus sequence (W box TTGAC[C/T]) shown to be recognized by WRKY factors with the GQK sequence. Mutation of the GKK sequence in NtWRKY12 into GQK or GEK abolished binding to the WK box. The WK(1) box is in close proximity to binding sites in the PR-1a promoter for transcription factors TGA1a (as-1 box) and Myb1 (MBSII box). Expression studies with PR-1a promoterbeta-glucuronidase (GUS) genes in stably and transiently transformed tobacco indicated that NtWRKY12 and TGA1a act synergistically in PR-1a expression induced by salicylic acid and bacterial elicitors. Cotransfection of Arabidopsis thaliana protoplasts with 35SNtWRKY12 and PR-1aGUS promoter fusions showed that overexpression of NtWRKY12 resulted in a strong increase in GUS expression, which required functional WK boxes in the PR-1a promoter.

Simulated star formation rate functions at z ˜ 4-7, and the role of feedback in high-z galaxies

NASA Astrophysics Data System (ADS)

Tescari, E.; Katsianis, A.; Wyithe, J. S. B.; Dolag, K.; Tornatore, L.; Barai, P.; Viel, M.; Borgani, S.

2014-03-01

We study the role of feedback from supernovae (SN) and black holes in the evolution of the star formation rate function (SFRF) of z ˜ 4-7 galaxies. We use a new set of cosmological hydrodynamic simulations, ANGUS (AustraliaN GADGET-3 early Universe Simulations), run with a modified and improved version of the parallel TreePM-smoothed particle hydrodynamics code GADGET-3 called P-GADGET3(XXL), that includes a self-consistent implementation of stellar evolution and metal enrichment. In our simulations both SN-driven galactic winds and active galactic nuclei (AGN) act simultaneously in a complex interplay. The SFRF is insensitive to feedback prescription at z > 5, meaning that it cannot be used to discriminate between feedback models during reionization. However, the SFRF is sensitive to the details of feedback prescription at lower redshift. By exploring different SN-driven wind velocities and regimes for the AGN feedback, we find that the key factor for reproducing the observed SFRFs is a combination of `strong' SN winds and early AGN feedback in low-mass galaxies. Conversely, we show that the choice of initial mass function and inclusion of metal cooling have less impact on the evolution of the SFRF. When variable winds are considered, we find that a non-aggressive wind scaling is needed to reproduce the SFRFs at z ≳ 4. Otherwise, the amount of objects with low SFRs is greatly suppressed and at the same time winds are not effective enough in the most massive systems.

Confidence level in venipuncture and knowledge on causes of in vitro hemolysis among healthcare professionals.

PubMed

Milutinović, Dragana; Andrijević, Ilija; Ličina, Milijana; Andrijević, Ljiljana

2015-01-01

This study aimed to assess confidence level of healthcare professionals in venipuncture and their knowledge on the possible causes of in vitro hemolysis. A sample of 94 healthcare professionals (nurses and laboratory technicians) participated in this survey study. A four-section questionnaire was used as a research instrument comprising general information for research participants, knowledge on possible causes of in vitro hemolysis due to type of material used and venipuncture technique and specimen handling, as well as assessment of healthcare professionals' confidence level in their own ability to perform first and last venipuncture. The average score on the knowledge test was higher in nurses' than in laboratory technicians (8.11±1.7, and 7.4±1.5, respectively). The difference in average scores was statistically significant (P=0.035) and Cohen's d in the range of 0.4 indicates that there is a moderate difference on the knowledge test among the health care workers. Only 11/94 of healthcare professionals recognized that blood sample collection from cannula and evacuated tube is method which contributes most to the occurrence of in vitro hemolysis, whereas most risk factors affecting occurrence of in vitro hemolysis during venipuncture were recognized. There were no significant differences in mean score on the knowledge test in relation to the confidence level in venipuncture (P=0.551). Confidence level at last venipuncture among both profiles of healthcare staff was very high, but they showed insufficient knowledge about possible factors affecting hemolysis due to materials used in venipuncture compared with factors due to venipuncture technique and handling of blood sample.

46 CFR 30.10-57 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Recognized classification society-TB/ALL. 30.10-57... Definitions § 30.10-57 Recognized classification society—TB/ALL. The term recognized classification society means the American Bureau of Shipping or other classification society recognized by the Commandant. ...

46 CFR 30.10-57 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Recognized classification society-TB/ALL. 30.10-57... Definitions § 30.10-57 Recognized classification society—TB/ALL. The term recognized classification society means the American Bureau of Shipping or other classification society recognized by the Commandant. ...

The ionization parameter of star-forming galaxies evolves with the specific star formation rate

NASA Astrophysics Data System (ADS)

Kaasinen, Melanie; Kewley, Lisa; Bian, Fuyan; Groves, Brent; Kashino, Daichi; Silverman, John; Kartaltepe, Jeyhan

2018-07-01

We investigate the evolution of the ionization parameter of star-forming galaxies using a high-redshift (z˜ 1.5) sample from the FMOS-COSMOS (Fibre Multi-Object Spectrograph-COSMic evOlution Survey) and matched low-redshift samples from the Sloan Digital Sky Survey. By constructing samples of low-redshift galaxies for which the stellar mass (M*), star formation rate (SFR), and specific star formation rate (sSFR) are matched to the high-redshift sample, we remove the effects of an evolution in these properties. We also account for the effect of metallicity by jointly constraining the metallicity and ionization parameter of each sample. We find an evolution in the ionization parameter for main-sequence, star-forming galaxies and show that this evolution is driven by the evolution of sSFR. By analysing the matched samples as well as a larger sample of z< 0.3, star-forming galaxies we show that high ionization parameters are directly linked to high sSFRs and are not simply the by-product of an evolution in metallicity. Our results are physically consistent with the definition of the ionization parameter, a measure of the hydrogen ionizing photon flux relative to the number density of hydrogen atoms.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Benjamin; Tan, Jonathan C.; Christie, Duncan

We study giant molecular cloud (GMC) collisions and their ability to trigger star cluster formation. We further develop our three-dimensional magnetized, turbulent, colliding GMC simulations by implementing star formation subgrid models. Two such models are explored: (1) “Density-Regulated,” i.e., fixed efficiency per free-fall time above a set density threshold and (2) “Magnetically Regulated,” i.e., fixed efficiency per free-fall time in regions that are magnetically supercritical. Variations of parameters associated with these models are also explored. In the non-colliding simulations, the overall level of star formation is sensitive to model parameter choices that relate to effective density thresholds. In the GMCmore » collision simulations, the final star formation rates and efficiencies are relatively independent of these parameters. Between the non-colliding and colliding cases, we compare the morphologies of the resulting star clusters, properties of star-forming gas, time evolution of the star formation rate (SFR), spatial clustering of the stars, and resulting kinematics of the stars in comparison to the natal gas. We find that typical collisions, by creating larger amounts of dense gas, trigger earlier and enhanced star formation, resulting in 10 times higher SFRs and efficiencies. The star clusters formed from GMC collisions show greater spatial substructure and more disturbed kinematics.« less

Stellar Population Synthesis of Star-forming Clumps in Galaxy Pairs and Non-interacting Spiral Galaxies

NASA Astrophysics Data System (ADS)

Zaragoza-Cardiel, Javier; Smith, Beverly J.; Rosado, Margarita; Beckman, John E.; Bitsakis, Theodoros; Camps-Fariña, Artemi; Font, Joan; Cox, Isaiah S.

2018-02-01

We have identified 1027 star-forming complexes in a sample of 46 galaxies from the Spirals, Bridges, and Tails (SB&T) sample of interacting galaxies, and 693 star-forming complexes in a sample of 38 non-interacting spiral (NIS) galaxies in 8 μm observations from the Spitzer Infrared Array Camera. We have used archival multi-wavelength UV-to IR observations to fit the observed spectral energy distribution of our clumps with the Code Investigating GALaxy Emission using a double exponentially declined star formation history. We derive the star formation rates (SFRs), stellar masses, ages and fractions of the most recent burst, dust attenuation, and fractional emission due to an active galactic nucleus for these clumps. The resolved star formation main sequence holds on 2.5 kpc scales, although it does not hold on 1 kpc scales. We analyzed the relation between SFR, stellar mass, and age of the recent burst in the SB&T and NIS samples, and we found that the SFR per stellar mass is higher in the SB&T galaxies, and the clumps are younger in the galaxy pairs. We analyzed the SFR radial profile and found that the SFR is enhanced through the disk and in the tidal features relative to normal spirals.

New insights into the interplay between the translation machinery and nonsense-mediated mRNA decay factors.

PubMed

Raimondeau, Etienne; Bufton, Joshua C; Schaffitzel, Christiane

2018-06-19

Faulty mRNAs with a premature stop codon (PTC) are recognized and degraded by nonsense-mediated mRNA decay (NMD). Recognition of a nonsense mRNA depends on translation and on the presence of NMD-enhancing or the absence of NMD-inhibiting factors in the 3'-untranslated region. Our review summarizes our current understanding of the molecular function of the conserved NMD factors UPF3B and UPF1, and of the anti-NMD factor Poly(A)-binding protein, and their interactions with ribosomes translating PTC-containing mRNAs. Our recent discovery that UPF3B interferes with human translation termination and enhances ribosome dissociation in vitro , whereas UPF1 is inactive in these assays, suggests a re-interpretation of previous experiments and modification of prevalent NMD models. Moreover, we discuss recent work suggesting new functions of the key NMD factor UPF1 in ribosome recycling, inhibition of translation re-initiation and nascent chain ubiquitylation. These new findings suggest that the interplay of UPF proteins with the translation machinery is more intricate than previously appreciated, and that this interplay quality-controls the efficiency of termination, ribosome recycling and translation re-initiation. © 2018 The Author(s).

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.

PubMed

Chong, P Andrew; Lin, Hong; Wrana, Jeffrey L; Forman-Kay, Julie D

2010-10-26

Smad ubiquitination regulatory factor 2 (Smurf2) is an E3 ubiquitin ligase that participates in degradation of TGF-β receptors and other targets. Smurf2 WW domains recognize PPXY (PY) motifs on ubiquitin ligase target proteins or on adapters, such as Smad7, that bind to E3 target proteins. We previously demonstrated that the isolated WW3 domain of Smurf2, but not the WW2 domain, can directly bind to a Smad7 PY motif. We show here that the WW2 augments this interaction by binding to the WW3 and making auxiliary contacts with the PY motif and a novel E/D-S/T-P motif, which is N-terminal to all Smad PY motifs. The WW2 likely enhances the selectivity of Smurf2 for the Smad proteins. NMR titrations confirm that Smad1 and Smad2 are bound by Smurf2 with the same coupled WW domain arrangement used to bind Smad7. The analogous WW domains in the short isoform of Smurf1 recognize the Smad7 PY peptide using the same coupled mechanism. However, a longer Smurf1 isoform, which has an additional 26 residues in the inter-WW domain linker, is only partially able to use the coupled WW domain binding mechanism. The longer linker results in a decrease in affinity for the Smad7 peptide. Interdomain coupling of WW domains enhances selectivity and enables the tuning of interactions by isoform switching.

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity

PubMed Central

Chong, P. Andrew; Lin, Hong; Wrana, Jeffrey L.; Forman-Kay, Julie D.

2010-01-01

Smad ubiquitination regulatory factor 2 (Smurf2) is an E3 ubiquitin ligase that participates in degradation of TGF-β receptors and other targets. Smurf2 WW domains recognize PPXY (PY) motifs on ubiquitin ligase target proteins or on adapters, such as Smad7, that bind to E3 target proteins. We previously demonstrated that the isolated WW3 domain of Smurf2, but not the WW2 domain, can directly bind to a Smad7 PY motif. We show here that the WW2 augments this interaction by binding to the WW3 and making auxiliary contacts with the PY motif and a novel E/D-S/T-P motif, which is N-terminal to all Smad PY motifs. The WW2 likely enhances the selectivity of Smurf2 for the Smad proteins. NMR titrations confirm that Smad1 and Smad2 are bound by Smurf2 with the same coupled WW domain arrangement used to bind Smad7. The analogous WW domains in the short isoform of Smurf1 recognize the Smad7 PY peptide using the same coupled mechanism. However, a longer Smurf1 isoform, which has an additional 26 residues in the inter-WW domain linker, is only partially able to use the coupled WW domain binding mechanism. The longer linker results in a decrease in affinity for the Smad7 peptide. Interdomain coupling of WW domains enhances selectivity and enables the tuning of interactions by isoform switching. PMID:20937913

Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.

PubMed

Fujiwara, Ryoichi; Maruo, Yoshihiro; Chen, Shujuan; Tukey, Robert H

2015-11-15

Newborns commonly develop physiological hyperbilirubinemia (also known as jaundice). With increased bilirubin levels being observed in breast-fed infants, breast-feeding has been recognized as a contributing factor for the development of neonatal hyperbilirubinemia. Bilirubin undergoes selective metabolism by UDP-glucuronosyltransferase (UGT) 1A1 and becomes a water soluble glucuronide. Although several factors such as gestational age, dehydration and weight loss, and increased enterohepatic circulation have been associated with breast milk-induced jaundice (BMJ), deficiency in UGT1A1 expression is a known cause of BMJ. It is currently believed that unconjugated bilirubin is metabolized mainly in the liver. However, recent findings support the concept that extrahepatic tissues, such as small intestine and skin, contribute to bilirubin glucuronidation during the neonatal period. We will review the recent advances made towards understanding biological and molecular events impacting BMJ, especially regarding the role of extrahepatic UGT1A1 expression. Copyright © 2015 Elsevier Inc. All rights reserved.

Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia

PubMed Central

Fujiwara, Ryoichi; Maruo, Yoshihiro; Chen, Shujuan; Tukey, Robert H.

2015-01-01

Newborns commonly develop physiological hyperbilirubinemia (also known as jaundice). With increased bilirubin levels being observed in breast-fed infants, breast-feeding has been recognized as a contributing factor for the development of neonatal hyperbilirubinemia. Bilirubin undergoes selective metabolism by UDP-glucuronosyltransferase (UGT) 1A1 and becomes a water soluble glucuronide. Although several factors such as gestational age, dehydration and weight loss, and increased enterohepatic circulation have been associated with breast milk-induced jaundice (BMJ), deficiency in UGT1A1 expression is a known cause of BMJ. It is currently believed that unconjugated bilirubin is metabolized mainly in the liver. However, recent findings support the concept that extrahepatic tissues, such as small intestine and skin, contribute to bilirubin glucuronidation during the neonatal period. We will review the recent advances made towards understanding biological and molecular events impacting BMJ, especially regarding the role of extrahepatic UGT1A1 expression. PMID:26342858

The Serial Use of Child Neurocognitive Tests: Development versus Practice Effects

ERIC Educational Resources Information Center

Slade, Peter D.; Townes, Brenda D.; Rosenbaum, Gail; Martins, Isabel P.; Luis, Henrique; Bernardo, Mario; Martin, Michael D.; DeRouen, Timothy A.

2008-01-01

When serial neurocognitive assessments are performed, 2 main factors are of importance: test-retest reliability and practice effects. With children, however, there is a third, developmental factor, which occurs as a result of maturation. Child tests recognize this factor through the provision of age-corrected scaled scores. Thus, a ready-made…

Directing traffic on DNA-How transcription factors relieve or induce transcriptional interference.

PubMed

Hao, Nan; Palmer, Adam C; Dodd, Ian B; Shearwin, Keith E

2017-03-15

Transcriptional interference (TI) is increasingly recognized as a widespread mechanism of gene control, particularly given the pervasive nature of transcription, both sense and antisense, across all kingdoms of life. Here, we discuss how transcription factor binding kinetics strongly influence the ability of a transcription factor to relieve or induce TI.

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

PubMed Central

Uematsu, Satoshi; Sato, Shintaro; Yamamoto, Masahiro; Hirotani, Tomonori; Kato, Hiroki; Takeshita, Fumihiko; Matsuda, Michiyuki; Coban, Cevayir; Ishii, Ken J.; Kawai, Taro; Takeuchi, Osamu; Akira, Shizuo

2005-01-01

Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells (pDCs). This induction requires the formation of a complex consisting of the adaptor MyD88, tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and IFN regulatory factor (IRF) 7. Here we show an essential role of IL-1 receptor-associated kinase (IRAK)-1 in TLR7- and TLR9-mediated IRF7 signaling pathway. IRAK-1 directly bound and phosphorylated IRF7 in vitro. The kinase activity of IRAK-1 was necessary for transcriptional activation of IRF7. TLR7- and TLR9-mediated IFN-α production was abolished in Irak-1–deficient mice, whereas inflammatory cytokine production was not impaired. Despite normal activation of NF-κB and mitogen-activated protein kinases, IRF7 was not activated by a TLR9 ligand in Irak-1–deficient pDCs. These results indicated that IRAK-1 is a specific regulator for TLR7- and TLR9-mediated IFN-α induction in pDCs. PMID:15767370

UV-luminous, star-forming hosts of z ~ 2 reddened quasars in the Dark Energy Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wethers, C. F.; Banerji, M.; Hewett, P. C.

We present the first rest-frame UV population study of 17 heavily reddened, high-luminosity (E(B-V)more » $$_{\\rm{QSO}}\\gtrsim$$ 0.5; L$$_{\\rm{bol}}>$$ 10$$^{46}$$ergs$$^{-1}$$) broad-line quasars at $1.5 < z < 2.7$. We combine the first year of deep, optical, ground-based observations from the Dark Energy Survey (DES) with the near infrared VISTA Hemisphere Survey (VHS) and UKIDSS Large Area Survey (ULAS) data, from which the reddened quasars were initially identified. We demonstrate that the significant dust reddening towards the quasar in our sample allows host galaxy emission to be detected at the rest-frame UV wavelengths probed by the DES photometry. By exploiting this reddening effect, we disentangle the quasar emission from that of the host galaxy via spectral energy distribution (SED) fitting. We find evidence for a relatively unobscured, star-forming host galaxy in at least ten quasars, with a further three quasars exhibiting emission consistent with either star formation or scattered light. From the rest-frame UV emission, we derive instantaneous, dust-corrected star formation rates (SFRs) in the range 25 < SFR$$_{\\rm{UV}}$$ < 365 M$$_{\\odot}$$yr$$^{-1}$$, with an average SFR$$_{\\rm{UV}}$$ = 130 $$\\pm$$ 95 M$$_{\\odot}$$yr$$^{-1}$$. In conclusion, we find a broad correlation between SFR$$_{\\rm{UV}}$$ and the bolometric quasar luminosity. Overall, our results show evidence for coeval star formation and black hole accretion occurring in luminous, reddened quasars at the peak epoch of galaxy formation.« less

UV-luminous, star-forming hosts of z ~ 2 reddened quasars in the Dark Energy Survey

DOE PAGES

Wethers, C. F.; Banerji, M.; Hewett, P. C.; ...

2018-01-05

We present the first rest-frame UV population study of 17 heavily reddened, high-luminosity (E(B-V)more » $$_{\\rm{QSO}}\\gtrsim$$ 0.5; L$$_{\\rm{bol}}>$$ 10$$^{46}$$ergs$$^{-1}$$) broad-line quasars at $1.5 < z < 2.7$. We combine the first year of deep, optical, ground-based observations from the Dark Energy Survey (DES) with the near infrared VISTA Hemisphere Survey (VHS) and UKIDSS Large Area Survey (ULAS) data, from which the reddened quasars were initially identified. We demonstrate that the significant dust reddening towards the quasar in our sample allows host galaxy emission to be detected at the rest-frame UV wavelengths probed by the DES photometry. By exploiting this reddening effect, we disentangle the quasar emission from that of the host galaxy via spectral energy distribution (SED) fitting. We find evidence for a relatively unobscured, star-forming host galaxy in at least ten quasars, with a further three quasars exhibiting emission consistent with either star formation or scattered light. From the rest-frame UV emission, we derive instantaneous, dust-corrected star formation rates (SFRs) in the range 25 < SFR$$_{\\rm{UV}}$$ < 365 M$$_{\\odot}$$yr$$^{-1}$$, with an average SFR$$_{\\rm{UV}}$$ = 130 $$\\pm$$ 95 M$$_{\\odot}$$yr$$^{-1}$$. In conclusion, we find a broad correlation between SFR$$_{\\rm{UV}}$$ and the bolometric quasar luminosity. Overall, our results show evidence for coeval star formation and black hole accretion occurring in luminous, reddened quasars at the peak epoch of galaxy formation.« less

Incidence and risk factors of acute kidney injury after esophageal cancer surgery: A nested case-control study.

PubMed

Wang, Wen; Wang, Tong; Feng, Xiaoshuang; Sun, Li

2017-03-01

Acute kidney injury (AKI) has been increasingly recognized as a common and serious postoperative complication. Although many studies have been conducted to investigate postoperative AKI after thoracic surgery, little is known about AKI after esophageal surgery. Thus, we conducted this study to determine the incidence and identify risk factors of postoperative AKI after esophageal cancer surgery. A retrospective nested case-control study of patients undergoing elective esophageal cancer surgery between July 2013 and July 2016 in a single tertiary specialized cancer hospital was performed. The primary outcome was development of AKI. Conditional logistic regression analysis was performed to identify independent risk factors for AKI. Of 2094 patients, 51 (2.4%) developed postoperative AKI after esophageal cancer surgery. In multivariate conditional logistic regression analysis, four risk factors for AKI after esophageal surgery for cancer were identified: preoperative serum creatinine level (OR 1.040; 95% CI 1.012-1.069), duration of surgery (OR 1.009; 95% CI 1.005-1.014), smoking history (OR 3.029; 95% CI 1.092-8.399) and hypertension (OR 6.422; 95% CI 2.736-15.070). Postoperative AKI occurred in 2.4% of patients after esophageal surgery for cancer. Preoperative serum creatinine level, duration of surgery, smoking history and hypertension were independent risk factors for postoperative AKI. Copyright © 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

Single-domain antibodies that compete with the natural ligand fibroblast growth factor block the internalization of the fibroblast growth factor receptor 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veggiani, Gianluca; Ossolengo, Giuseppe; Aliprandi, Marisa

2011-05-20

Highlights: {yields} Recombinant antibodies for FGFR1 were isolated from a llama naive library in VHH format. {yields} These antibodies compete with the natural ligand FGF-2 for the same epitope on FGFR1. {yields} The antibody competition inhibits the FGF-2-dependent internalization of FGFR1. -- Abstract: Single-domain antibodies in VHH format specific for fibroblast growth factor receptor 1 (FGFR1) were isolated from a phage-display llama naive library. In particular, phage elution in the presence of the natural receptor ligand fibroblast growth factor (FGF) allowed for the identification of recombinant antibodies that compete with FGF for the same region on the receptor surface. Thesemore » antibodies posses a relatively low affinity for FGFR1 and were never identified when unspecific elution conditions favoring highly affine binders were applied to panning procedures. Two populations of competitive antibodies were identified that labeled specifically the receptor-expressing cells in immunofluorescence and recognize distinct epitopes. Antibodies from both populations effectively prevented FGF-dependent internalization and nuclear accumulation of the receptor in cultured cells. This achievement indicates that these antibodies have a capacity to modulate the receptor physiology and, therefore, constitute powerful reagents for basic research and a potential lead for therapeutic applications.« less

Authoritative school climate, number of parents at home, and academic achievement.

PubMed

Huang, Francis L; Eklund, Katie; Cornell, Dewey G

2017-12-01

School climate is widely recognized as an important factor in promoting student academic achievement. The current study investigated the hypothesis that a demanding and supportive school climate, based on authoritative school climate theory, would serve as a protective factor for students living with 1 or no parents at home. Using a statewide sample of 56,508 middle school students from 415 public schools in 1 state, results indicated that student perceptions of disciplinary structure, academic demandingness, and student support all had positive associations with student self-reported grade point average (GPA). In addition, findings showed that academic expectations and student support were more highly associated with GPA for students not living with any parent. Implications for policy and practice are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Determination of polycyclic aromatic hydrocarbons by four-way parallel factor analysis in presence of humic acid.

PubMed

Yang, Ruifang; Zhao, Nanjing; Xiao, Xue; Yu, Shaohui; Liu, Jianguo; Liu, Wenqing

2016-01-05

There is not effective method to solve the quenching effect of quencher in fluorescence spectra measurement and recognition of polycyclic aromatic hydrocarbons in aquatic environment. In this work, a four-way dataset combined with four-way parallel factor analysis is used to identify and quantify polycyclic aromatic hydrocarbons in the presence of humic acid, a fluorescent quencher and an ubiquitous substance in aquatic system, through modeling the quenching effect of humic acid by decomposing the four-way dataset into four loading matrices corresponding to relative concentration, excitation spectra, emission spectra and fluorescence quantum yield, respectively. It is found that Phenanthrene, pyrene, anthracene and fluorene can be recognized simultaneously with the similarities all above 0.980 between resolved spectra and reference spectra. Moreover, the concentrations of them ranging from 0 to 8μgL(-1) in the test samples prepared with river water could also be predicted successfully with recovery rate of each polycyclic aromatic hydrocarbon between 100% and 120%, which were higher than those of three-way PARAFAC. These results demonstrate that the combination of four-way dataset with four-way parallel factor analysis could be a promising method to recognize the fluorescence spectra of polycyclic aromatic hydrocarbons in the presence of fluorescent quencher from both qualitative and quantitative perspective. Copyright © 2015 Elsevier B.V. All rights reserved.

The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors.

PubMed

Valiante, Vito; Baldin, Clara; Hortschansky, Peter; Jain, Radhika; Thywißen, Andreas; Straßburger, Maria; Shelest, Ekaterina; Heinekamp, Thorsten; Brakhage, Axel A

2016-10-01

Melanins play a crucial role in defending organisms against external stressors. In several pathogenic fungi, including the human pathogen Aspergillus fumigatus, melanin production was shown to contribute to virulence. A. fumigatus produces two different types of melanins, i.e., pyomelanin and dihydroxynaphthalene (DHN)-melanin. DHN-melanin forms the gray-green pigment characteristic for conidia, playing an important role in immune evasion of conidia and thus for fungal virulence. The DHN-melanin biosynthesis pathway is encoded by six genes organized in a cluster with the polyketide synthase gene pksP as a core element. Here, cross-species promoter analysis identified specific DNA binding sites in the DHN-melanin biosynthesis genes pksP-arp1 intergenic region that can be recognized by bHLH and MADS-box transcriptional regulators. Independent deletion of two genes coding for the transcription factors DevR (bHLH) and RlmA (MADS-box) interfered with sporulation and reduced the expression of the DHN-melanin gene cluster. In vitro and in vivo experiments proved that these transcription factors cooperatively regulate pksP expression acting both as repressors and activators in a mutually exclusive manner. The dual role executed by each regulator depends on specific DNA motifs recognized in the pksP promoter region. © 2016 John Wiley & Sons Ltd.

Hospital-acquired gangrenous mucormycosis.

PubMed Central

Patterson, J. E.; Barden, G. E.; Bia, F. J.

1986-01-01

A post-operative diabetic patient who had been treated for Serratia marcescens bacterial sepsis developed recurrent thrombosis of the left femoral artery following intra-arterial instrumentation. Pathological examination of arterial thrombus ultimately demonstrated invasive mucormycosis of the femoral artery and cultures of this material grew Rhizopus oryzae. The occurrence of cutaneous and subcutaneous mucormycosis is reviewed, as well as recently recognized nosocomial risk factors for mucormycosis, such as elasticized bandages and wound dressings. Images FIG. 1 FIG. 2 FIG. 3 PMID:3765666

Concurrent Supermassive Black Hole and Galazy Growth: Linking Environment and Nuclear Activity in Zeta Equals 2.23 H Alpha Emitters

NASA Technical Reports Server (NTRS)

Lehmer, B. D.; Lucy, A. B.; Alexander, D. M.; Best, P. N.; Geach, J. E.; Harrison, C. M.; Hornschemeier, A. E.; Matsuda, Y.; Mullaney, J. R.; Smail, Ian;

Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A

PubMed Central

Aksu, Metin; Trakhanov, Sergei; Görlich, Dirk

2016-01-01

Xpo4 is a bidirectional nuclear transport receptor that mediates nuclear export of eIF5A and Smad3 as well as import of Sox2 and SRY. How Xpo4 recognizes such a variety of cargoes is as yet unknown. Here we present the crystal structure of the RanGTP·Xpo4·eIF5A export complex at 3.2 Å resolution. Xpo4 has a similar structure as CRM1, but the NES-binding site is occluded, and a new interaction site evolved that recognizes both globular domains of eIF5A. eIF5A contains hypusine, a unique amino acid with two positive charges, which is essential for cell viability and eIF5A function in translation. The hypusine docks into a deep, acidic pocket of Xpo4 and is thus a critical element of eIF5A's complex export signature. This further suggests that Xpo4 recognizes other cargoes differently, and illustrates how Xpo4 suppresses – in a chaperone-like manner – undesired interactions of eIF5A inside nuclei. PMID:27306458

Crew Communication as a Factor in Aviation Accidents

NASA Technical Reports Server (NTRS)

Goguen, J.; Linde, C.; Murphy, M.

1986-01-01

The crew communication process is analyzed. Planning and explanation are shown to be well-structured discourse types, described by formal rules. These formal rules are integrated with those describing the other most important discourse type within the cockpit: the command-and-control speech act chain. The latter is described as a sequence of speech acts for making requests (including orders and suggestions), for making reports, for supporting or challenging statements, and for acknowledging previous speech acts. Mitigation level, a linguistic indication of indirectness and tentativeness in speech, was an important variable in several hypotheses, i.e., the speech of subordinates is more mitigated than the speech of superiors, the speech of all crewmembers is less mitigated when they know that they are in either a problem or emergency situation, and mitigation is a factor in failures of crewmembers to initiate discussion of new topics or have suggestions ratified by the captain. Test results also show that planning and explanation are more frequently performed by captains, are done more during crew- recognized problems, and are done less during crew-recognized emergencies. The test results also indicated that planning and explanation are more frequently performed by captains than by other crewmembers, are done more during crew-recognized problems, and are done less during-recognized emergencies.

SHARDS: A Global View of the Star Formation Activity at z ~ 0.84 and z ~ 1.23

NASA Astrophysics Data System (ADS)

Cava, Antonio; Pérez-González, Pablo G.; Eliche-Moral, M. Carmen; Ricciardelli, Elena; Vidal-García, Alba; Alcalde Pampliega, Belen; Alonso-Herrero, Almudena; Barro, Guillermo; Cardiel, Nicolas; Cenarro, A. Javier; Charlot, Stephane; Daddi, Emanuele; Dessauges-Zavadsky, Miroslava; Domínguez Sánchez, Helena; Espino-Briones, Nestor; Esquej, Pilar; Gallego, Jesus; Hernán-Caballero, Antonio; Huertas-Company, Marc; Koekemoer, Anton M.; Muñoz-Tunon, Casiana; Rodriguez-Espinosa, Jose M.; Rodríguez-Muñoz, Lucia; Tresse, Laurence; Villar, Victor

2015-10-01

In this paper, we present a comprehensive analysis of star-forming galaxies (SFGs) at intermediate redshifts (z ˜ 1). We combine the ultra-deep optical spectro-photometric data from the Survey for High-z Absorption Red and Dead Sources (SHARDS) with deep UV-to-FIR observations in the GOODS-N field. Exploiting two of the 25 SHARDS medium-band filters, F687W17 and F823W17, we select [O ii] emission line galaxies at z ˜ 0.84 and z ˜ 1.23 and characterize their physical properties. Their rest-frame equivalent widths (EWrf([O ii])), line fluxes, luminosities, star formation rates (SFRs), and dust attenuation properties are investigated. The evolution of EWrf([O ii]) closely follows the SFR density evolution of the universe, with a trend of EWrf([O ii]) \\propto (1 + z)3 up to redshift z ≃ 1, followed by a possible flattening. The SF properties of the galaxies selected on the basis of their [O ii] emission are compared with complementary samples of SFGs selected by their MIR and FIR emission, and also with a general mass-selected sample of galaxies at the same redshifts. We demonstrate observationally that the UVJ diagram (or, similarly, a cut in the specific SFR) is only partially able to distinguish the quiescent galaxies from the SFGs. The SFR-M* relation is investigated for the different samples, yielding a logarithmic slope ˜1, in good agreement with previous results. The dust attenuations derived from different SFR indicators (UV(1600), UV(2800), [O ii], IR) are compared and show clear trends with respect to both the stellar mass and total SFR, with more massive and highly star-forming galaxies being affected by stronger dust attenuation.

Factors Predictive Of Alcohol Consumption Among Elderly People In A Rural Community: A Case Study In Phayao Province Thailand.

PubMed

Hongthong, Donnapa; Somrongthong, Ratana; Wongchaiya, Pimpimon; Kumar, Ramesh

2016-01-01

Alcohol consumption is recognized as a public health issue. Study objectives were to identify factors predictive of alcohol consumption among elderly people in Phayao province Thailand, where there was high prevalence of alcohol consumption. This was a cross-sectional study. Four hundred elderly people participated in a survey. Data was collected by face-to-face interviews. Chi-square and multivariate logistic regression were used to determine the factors predictive of alcohol consumption among the study subjects. One thirds of elderly (31.7%) had consumed alcohol in their lifetime, and (15.7%) of them were current drinkers. Following univariate analysis, seven factors included gender, working, sickness, smoking, quality of life (QOL), daily activities and economic recession - were identified as being significantly associated with drinking (p<0.05). Multivariate analysis revealed four factors to be predictive of alcohol among elderly people: gender (OR=6.02, 95% CI=3.58-10.13), smoking (OR=4.34, 95% CI=2.57-7.34), economic recession (OR=2.79, 95%, CI=1.66-4.71), and QOL (OR=1.86, 95%, CI=1.09-3.16). Gender (male) and smoking were strongly predictive factors of elderly alcohol consumption. Hence, an effort to reduce alcohol consumption should be placed on male elderly and those who smoke.

Cell proteins bind to multiple sites within the 5' untranslated region of poliovirus RNA.

PubMed Central

del Angel, R M; Papavassiliou, A G; Fernández-Tomás, C; Silverstein, S J; Racaniello, V R

1989-01-01

The 5' noncoding region of poliovirus RNA contains sequences necessary for translation and replication. These functions are probably carried out by recognition of poliovirus RNA by cellular and/or viral proteins. Using a mobility-shift electrophoresis assay and 1,10-phenanthroline/Cu+ footprinting, we demonstrate specific binding of cytoplasmic factors with a sequence from nucleotides 510-629 within the 5' untranslated region (UTR). Complex formation was also observed with a second sequence (nucleotides 97-182) within the 5' UTR. These two regions of the 5' UTR appear to be recognized by distinct cell factors as determined by competition analysis and the effects of ionic strength on complex formation. However, both complexes contain eukaryotic initiation factor 2 alpha, as revealed by their reaction with specific antibody. Images PMID:2554308

Recognition of maximum flooding events in mixed siliciclastic-carbonate systems: Key to global chronostratigraphic correlation

USGS Publications Warehouse

Mancini, E.A.; Tew, B.H.

1997-01-01

The maximum flooding event within a depositional sequence is an important datum for correlation because it represents a virtually synchronous horizon. This event is typically recognized by a distinctive physical surface and/or a significant change in microfossil assemblages (relative fossil abundance peaks) in siliciclastic deposits from shoreline to continental slope environments in a passive margin setting. Recognition of maximum flooding events in mixed siliciclastic-carbonate sediments is more complicated because the entire section usually represents deposition in continental shelf environments with varying rates of biologic and carbonate productivity versus siliciclastic influx. Hence, this event cannot be consistently identified simply by relative fossil abundance peaks. Factors such as siliciclastic input, carbonate productivity, sediment accumulation rates, and paleoenvironmental conditions dramatically affect the relative abundances of microfossils. Failure to recognize these complications can lead to a sequence stratigraphic interpretation that substantially overestimates the number of depositional sequences of 1 to 10 m.y. duration.

A Primary Care Approach to the Diagnosis and Management of Peripheral Arterial Disease

NASA Technical Reports Server (NTRS)

Dawson, David L.

2000-01-01

The objectives of this work are: (1) Be able to recognize characteristic symptoms of intermittent claudication (2) Diagnose PAD on the basis of history, physical exam, and simple limb blood pressure measurements (3) Recognize the significance of peripheral artery disease as a marker for coronary or cerebrovascular atherosclerosis (4) Provide appropriate medical management of atherosclerosis risk factors-- including use of antiplatelet therapy to reduce risk of myocardial infarction, stroke and death (5) Manage symptoms of intermittent claudication with program of smoking cessation, exercise, and medication The diagnosis of intermittent claudication secondary to peripheral artery disease (PAD) can often be made on the basis of history and physical examination. Additional evaluation of PAD is multi-modal and the techniques used will vary depending on the nature and severity of the patient's presenting problem. Most patients can be appropriately managed without referral for specialized diagnostic services or interventions.

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.

PubMed

Muth, V; Nadaud, S; Grummt, I; Voit, R

2001-03-15

Mammalian rRNA genes are preceded by a terminator element that is recognized by the transcription termination factor TTF-I. In exploring the functional significance of the promoter-proximal terminator, we found that TTF-I associates with the p300/CBP-associated factor PCAF, suggesting that TTF-I may target histone acetyltransferase to the rDNA promoter. We demonstrate that PCAF acetylates TAF(I)68, the second largest subunit of the TATA box-binding protein (TBP)-containing factor TIF-IB/SL1, and acetylation enhances binding of TAF(I)68 to the rDNA promoter. Moreover, PCAF stimulates RNA polymerase I (Pol I) transcription in a reconstituted in vitro system. Consistent with acetylation of TIF-IB/SL1 being required for rDNA transcription, the NAD(+)-dependent histone deacetylase mSir2a deacetylates TAF(I)68 and represses Pol I transcription. The results demonstrate that acetylation of the basal Pol I transcription machinery has functional consequences and suggest that reversible acetylation of TIF-IB/SL1 may be an effective means to regulate rDNA transcription in response to external signals.

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

PubMed Central

Cavigelli, M; Dolfi, F; Claret, F X; Karin, M

1995-01-01

Growth factors induce c-fos transcription by stimulating phosphorylation of transcription factor TCF/Elk-1, which binds to the serum response element (SRE). Under such conditions Elk-1 could be phosphorylated by the mitogen-activated protein kinases (MAPKs) ERK1 and ERK2. However, c-fos transcription and SRE activity are also induced by stimuli, such as UV irradiation and activation of the protein kinase MEKK1, that cause only an insignificant increase in ERK1/2 activity. However, both of these stimuli strongly activate two other MAPKs, JNK1 and JNK2, and stimulate Elk-1 transcriptional activity and phosphorylation. We find that the JNKs are the predominant Elk-1 activation domain kinases in extracts of UV-irradiated cells and that immunopurified JNK1/2 phosphorylate Elk-1 on the same major sites recognized by ERK1/2, that potentiate its transcriptional activity. Finally, we show that UV irradiation, but not serum or phorbol esters, stimulate translocation of JNK1 to the nucleus. As Elk-1 is most likely phosphorylated while bound to the c-fos promoter, these results suggest that UV irradiation and MEKK1 activation stimulate TCF/Elk-1 activity through JNK activation, while growth factors induce c-fos through ERK activation. Images PMID:8846788

Strong Showing for AGU Journals in 2009 Impact Factors

NASA Astrophysics Data System (ADS)

Cook, Bill

2010-06-01

AGU publishes great science, which is recognized in several ways. One of the most widely recognized is from Thomson Reuters, which provides the Journal Citation Report (JCR) each year as a component of the Web of Science®. JCR reports on several measures of journal usage, including a journal's Eigenfactor score, its Article Influence score, its Impact Factor, and its rank within a cohort of similar journals. According to the 2009 statistics released last week, AGU again has outperformed its larger competitors. For the twelfth time, two different AGU titles hold the top rank in their categories, and AGU titles hold the second spot in two other categories and third in two more.

The nuclear matrix protein NMP-1 is the transcription factor YY1.

PubMed Central

Guo, B; Odgren, P R; van Wijnen, A J; Last, T J; Nickerson, J; Penman, S; Lian, J B; Stein, J L; Stein, G S

1995-01-01

NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for the site IV regulatory element of a histone H4 gene. This distal promoter domain is a nuclear matrix interaction site. In the present study, we show that NMP-1 is the multifunctional transcription factor YY1. Gel-shift and Western blot analyses demonstrate that NMP-1 is immunoreactive with YY1 antibody. Furthermore, purified YY1 protein specifically recognizes site IV and reconstitutes the NMP-1 complex. Western blot and gel-shift analyses indicate that YY1 is present within the nuclear matrix. In situ immunofluorescence studies show that a significant fraction of YY1 is localized in the nuclear matrix, principally but not exclusively associated with residual nucleoli. Our results confirm that NMP-1/YY1 is a ubiquitous protein that is present in both human cells and in rat osteosarcoma ROS 17/2.8 cells. The finding that NMP-1 is identical to YY1 suggests that this transcriptional regulator may mediate gene-matrix interactions. Our results are consistent with the concept that the nuclear matrix may functionally compartmentalize the eukaryotic nucleus to support regulation of gene expression. Images Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7479833

The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family.

PubMed

Galarneau, L; Paré, J F; Allard, D; Hamel, D; Levesque, L; Tugwood, J D; Green, S; Bélanger, L

1996-07-01

The alpha1-fetoprotein (AFP) gene is located between the albumin and alpha-albumin genes and is activated by transcription factor FTF (fetoprotein transcription factor), presumed to transduce early developmental signals to the albumin gene cluster. We have identified FTF as an orphan nuclear receptor of the Drosophila FTZ-F1 family. FTF recognizes the DNA sequence 5'-TCAAGGTCA-3', the canonical recognition motif for FTZ-F1 receptors. cDNA sequence homologies indicate that rat FTF is the ortholog of mouse LRH-1 and Xenopus xFF1rA. Rodent FTF is encoded by a single-copy gene, related to the gene encoding steroidogenic factor 1 (SF-1). The 5.2-kb FTF transcript is translated from several in-frame initiator codons into FTF isoforms (54 to 64 kDa) which appear to bind DNA as monomers, with no need for a specific ligand, similar KdS (approximately equal 3 x 10(-10) M), and similar transcriptional effects. FTF activates the AFP promoter without the use of an amino-terminal activation domain; carboxy-terminus-truncated FTF exerts strong dominant negative effects. In the AFP promoter, FTF recruits an accessory trans-activator which imparts glucocorticoid reactivity upon the AFP gene. FTF binding sites are found in the promoters of other liver-expressed genes, some encoding liver transcription factors; FTF, liver alpha1-antitrypsin promoter factor LFB2, and HNF-3beta promoter factor UF2-H3beta are probably the same factor. FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues. HepG2 hepatoma cells seem to express a mutated form of FTF.

Behavior problems in children at time of first recognized seizure and changes over the following 3 years.

PubMed

Austin, J K; Perkins, S M; Johnson, C S; Fastenau, P S; Byars, A W; deGrauw, T J; Dunn, D W

2011-08-01

The purposes of this 36-month study of children with first recognized seizures were: (1) to describe baseline differences in behavior problems between children with and without prior unrecognized seizures; (2) to identify differences over time in behavior problems between children with seizures and their healthy siblings; (3) to identify the proportions of children with seizures and healthy siblings who were consistently at risk for behavior problems for 36 months; and (4) to identify risk factors for behavior problems 36 months following the first recognized seizure. Risk factors explored included demographic (child age and gender, caregiver education), neuropsychological (IQ, processing speed), seizure (epileptic syndrome, use of antiepileptic drug, seizure recurrence), and family (family mastery, satisfaction with family relationships, parent response) variables. Participants were 300 children aged 6 through 14 years with a first recognized seizure and 196 healthy siblings. Data were collected from medical records, structured interviews, self-report questionnaires, and neuropsychological testing. Behavior problems were measured using the Child Behavior Checklist and the Teacher's Report Form. Data analyses included descriptive statistics and linear mixed models. Children with prior unrecognized seizures were at higher risk for behavior problems at baseline. As a group, children with seizures showed a steady reduction in behavior problems over time. Children with seizures were found to have significantly more behavior problems than their siblings over time, and significantly more children with seizures (11.3%) than siblings (4.6%) had consistent behavior problems over time. Key risk factors for child behavior problems based on both caregivers and teachers were: less caregiver education, slower initial processing speed, slowing of processing speed over the first 36 months, and a number of family variables including lower levels of family mastery or child satisfaction with family relationships, lower parent support of the child's autonomy, and lower parent confidence in their ability to discipline their child. Children with new-onset seizures who are otherwise developing normally have higher rates of behavior problems than their healthy siblings; however, behavior problems are not consistently in the at-risk range in most children during the first 3 years after seizure onset. When children show behavior problems, family variables that might be targeted include family mastery, parent support of child autonomy, and parents' confidence in their ability to handle their children's behavior.

Quantifying lead-time bias in risk factor studies of cancer through simulation.

PubMed

Jansen, Rick J; Alexander, Bruce H; Anderson, Kristin E; Church, Timothy R

2013-11-01

Lead-time is inherent in early detection and creates bias in observational studies of screening efficacy, but its potential to bias effect estimates in risk factor studies is not always recognized. We describe a form of this bias that conventional analyses cannot address and develop a model to quantify it. Surveillance Epidemiology and End Results (SEER) data form the basis for estimates of age-specific preclinical incidence, and log-normal distributions describe the preclinical duration distribution. Simulations assume a joint null hypothesis of no effect of either the risk factor or screening on the preclinical incidence of cancer, and then quantify the bias as the risk-factor odds ratio (OR) from this null study. This bias can be used as a factor to adjust observed OR in the actual study. For this particular study design, as average preclinical duration increased, the bias in the total-physical activity OR monotonically increased from 1% to 22% above the null, but the smoking OR monotonically decreased from 1% above the null to 5% below the null. The finding of nontrivial bias in fixed risk-factor effect estimates demonstrates the importance of quantitatively evaluating it in susceptible studies. Copyright © 2013 Elsevier Inc. All rights reserved.

An Outbreak of Diarrhea in Mandera, Kenya, Due to Escherichia coli Serogroup O-Nontypable Strain That Had a Coding Gene for Enteroaggregative E. coli Heat-Stable Enterotoxin 1.

PubMed

Ochi, Sadayuki; Shah, Mohammad; Odoyo, Erick; Bundi, Martin; Miringu, Gabriel; Guyo, Sora; Wandera, Ernest; Kathiiko, Cyrus; Kariuki, Samuel; Karama, Mohamed; Tsuji, Takao; Ichinose, Yoshio

2017-02-08

In an outbreak of gastroenteritis in December 2009, in Mandera, Kenya, Escherichia coli O-nontypable (ONT) strain was isolated from stool specimens of patients (18/24, 75%). The E. coli ONT organisms could not be assigned to any of the recognized diarrheagenic groups of E. coli However, they possessed the enteroaggregative E. coli heat-stable enterotoxin-1 gene. The cell-free culture filtrates of the E. coli ONT strain isolated from the outbreak cases induced considerable amount of fluid accumulation in suckling mouse intestine, indicating production of an enterotoxic factor(s). These results identify E. coli that did not have any diarrheagenic characteristics except astA as the etiological agent of the diarrheal outbreak in Mandera. It is however considered necessary to characterize the fluid accumulation factor(s) to determine whether any novel toxins were responsible for the fluid accumulation. Moreover, it is important to study dissemination of strains producing the enterotoxic factor(s) to assess their public health significance distribution in the environment. © The American Society of Tropical Medicine and Hygiene.

Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure.

PubMed

Polyak, Maria J; Deans, Julie P

2002-05-01

In vivo ablation of malignant B cells can be achieved using antibodies directed against the CD20 antigen. Fine specificity differences among CD20 monoclonal antibodies (mAbs) are assumed not to be a factor in determining their efficacy because evidence from antibody-blocking studies indicates limited epitope diversity with only 2 overlapping extracellular CD20 epitopes. However, in this report a high degree of heterogeneity among antihuman CD20 mAbs is demonstrated. Mutation of alanine and proline at positions 170 and 172 (AxP) (single-letter amino acid codes; x indicates the identical amino acid at the same position in the murine and human CD20 sequences) in human CD20 abrogated the binding of all CD20 mAbs tested. Introduction of AxP into the equivalent positions in the murine sequence, which is not otherwise recognized by antihuman CD20 mAbs, fully reconstituted the epitope recognized by B1, the prototypic anti-CD20 mAb. 2H7, a mAb previously thought to recognize the same epitope as B1, did not recognize the murine AxP mutant. Reconstitution of the 2H7 epitope was achieved with additional mutations replacing VDxxD in the murine sequence for INxxN (positions 162-166 in the human sequence). The integrity of the 2H7 epitope, unlike that of B1, further depends on the maintenance of CD20 in an oligomeric complex. The majority of 16 antihuman CD20 mAbs tested, including rituximab, bound to murine CD20 containing the AxP mutations. Heterogeneity in the fine specificity of these antibodies was indicated by marked differences in their ability to induce homotypic cellular aggregation and translocation of CD20 to a detergent-insoluble membrane compartment previously identified as lipid rafts.

Effectiveness of interventions to provide culturally appropriate maternity care in increasing uptake of skilled maternity care: a systematic review.

PubMed

Coast, Ernestina; Jones, Eleri; Lattof, Samantha R; Portela, Anayda

2016-12-01

Addressing cultural factors that affect uptake of skilled maternity care is recognized as an important step in improving maternal and newborn health. This article describes a systematic review to examine the evidence available on the effects of interventions to provide culturally appropriate maternity care on the use of skilled maternity care during pregnancy, for birth or in the postpartum period. Items published in English, French and/or Spanish between 1 January 1990 and 31 March 2014 were considered. Fifteen studies describing a range of interventions met the inclusion criteria. Data were extracted on population and intervention characteristics; study design; definitions and data for relevant outcomes; and the contexts and conditions in which interventions occurred. Because most of the included studies focus on antenatal care outcomes, evidence of impact is particularly limited for care seeking for birth and after birth. Evidence in this review is clustered within a small number of countries, and evidence from low- and middle-income countries is notably lacking. Interventions largely had positive effects on uptake of skilled maternity care. Cultural factors are often not the sole factor affecting populations' use of maternity care services. Broader social, economic, geographical and political factors interacted with cultural factors to affect targeted populations' access to services in included studies. Programmes and policies should seek to establish an enabling environment and support respectful dialogue with communities to improve use of skilled maternity care. Whilst issues of culture are being recognized by programmes and researchers as being important, interventions that explicitly incorporate issues of culture are rarely evaluated. © The Author 2016. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.

Seismic High Attenuation Region Observed Beneath Southern New England From Teleseismic Body Wave Spectra: Evidence for High Asthenospheric Temperature Without Melt

NASA Astrophysics Data System (ADS)

Dong, Mingduo T.; Menke, William H.

2017-11-01

Seismic attenuation exhibits strong geographic variability in northeastern North America, with the highest values associated with the previously recognized Northern Appalachian Anomaly (NAA) in southern New England. The shear wave quality factor at 100 km depth is 14 < QS < 25, the ratio of P wave and S wave quality factors is QP/QS = 1.2 ± 0.03 (95%), and the frequency dependence parameter is α = 0.39 ± 0.025 (95%). The high values of QP/QS and α are compatible with laboratory measurements of unmelted rock and, in the case of α, incompatible with widespread melting. The low QS implies high mantle temperatures ( 1,550-1,650°C) at 100 km depth (assuming no melt). Small-scale variations in attenuation suggest structural heterogeneity within the NAA, possibly due to lithospheric delamination caused by asthenospheric flow.

Differences in maintenance of mean blood glucose (BG) and their association with response to “recognizing hunger”

PubMed Central

Ciampolini, Mario; Sifone, Massimiliano

2011-01-01

Background: Meals begin and end subjectively. We trained healthy subjects to recognize initial hunger as a preprandial target for meal consumption, and to create a “recognizing hunger” or initial hunger meal pattern. Objective: Training subjects to “recognize hunger” lowers blood glucose (BG) and improves energy balance, and lowers metabolic risks and bodyweight. A minority may have low BG and low metabolic risks at recruitment, but the others may recover this favorable condition by training. Methods: In a 7-day food diary, subjects reported their preprandial BG measurements; BG and energy availability by blood were assessed at the lowest BG during the day, and diary-mean BG thus characterized the individual meal pattern (daily energy intake). We analyzed the same diaries of a recent paper on a global, randomized comparison of subjects trained in “recognizing hunger” with control subjects. This time, we checked whether subjects who had maintained low BG (LBG subgroup) at recruitment were able to decrease mean BG and metabolic risk factors during “hunger recognition” like those who presented high BG (HBG subgroup). Results: At recruitment, the BG means of 120 investigated subjects were within mean confidence limits of ± 3.84 mg/dL, and we could stratify subjects in ten small strata of which each significantly differed by mean BG. Mean BG was stable in each control subject over five months; the mean absolute change being 6.0 ± 4.6 mg/dL. Only three out of 34 trained subjects who had lower mean BG than 81.8 mg/dL significantly decreased mean BG, whereas 41 out of 55 subjects whose mean BG was greater than 81.8 mg/dL significantly decreased mean BG after training (P < 0.0001). At recruitment, the LBG subgroup showed significantly lower insulin, lower BG area under curve (AUC) in the oral glucose tolerance test (GTT), and lower HbA1c than the HBG group. After training, only HBG subjects, compared with HBG controls, significantly decreased preprandial BG from 91.6 ± 7.7 mg/dL to 81.0 ± 7.7 mg/dL, in association with a decrease of HbA1c from 4.81% ± 0.44% to 4.56% ± 0.47%, of GTT insulin AUC from 244 ± 138 mU/L to 164 ± 92 mU/L, and of energy intake from 1872 ± 655 kcal to 1251 ± 470 kcal (P < 0.001), with an increase of indices of insulin sensitivity from 5.9 ± 3.3 to 9.8 ± 5.6 and of beta cell function from 1.0 ± 0.7 to 1.4 ± 1.1 (P < 0.05). LBG subjects only decreased weekly-diary BG standard deviation in comparison with controls. Conclusion: At recruitment, the 120 subjects maintained mean BG at one personal level of ten possibilities, and 34 subjects were below 81.8 mg/dL (LBG) and 55 were over (HBG). The 55 HBG subjects showed higher mean insulin resistance, HbA1c, other cardiovascular risk factors, and increased bodyweight compared with the 34 LBG subjects. A total of 41 out of the 55 HBG subjects regressed to LBG with training. PMID:21731891

A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model*

PubMed Central

Moayeri, Mahtab; Leysath, Clinton E.; Tremblay, Jacqueline M.; Vrentas, Catherine; Crown, Devorah; Leppla, Stephen H.; Shoemaker, Charles B.

2015-01-01

Anthrax disease is caused by a toxin consisting of protective antigen (PA), lethal factor, and edema factor. Antibodies against PA have been shown to be protective against the disease. Variable domains of camelid heavy chain-only antibodies (VHHs) with affinity for PA were obtained from immunized alpacas and screened for anthrax neutralizing activity in macrophage toxicity assays. Two classes of neutralizing VHHs were identified recognizing distinct, non-overlapping epitopes. One class recognizes domain 4 of PA at a well characterized neutralizing site through which PA binds to its cellular receptor. A second neutralizing VHH (JKH-C7) recognizes a novel epitope. This antibody inhibits conversion of the PA oligomer from “pre-pore” to its SDS and heat-resistant “pore” conformation while not preventing cleavage of full-length 83-kDa PA (PA83) by cell surface proteases to its oligomer-competent 63-kDa form (PA63). The antibody prevents endocytosis of the cell surface-generated PA63 subunit but not preformed PA63 oligomers formed in solution. JKH-C7 and the receptor-blocking VHH class (JIK-B8) were expressed as a heterodimeric VHH-based neutralizing agent (VNA2-PA). This VNA displayed improved neutralizing potency in cell assays and protected mice from anthrax toxin challenge with much better efficacy than the separate component VHHs. The VNA protected virtually all mice when separately administered at a 1:1 ratio to toxin and protected mice against Bacillus anthracis spore infection. Thus, our studies show the potential of VNAs as anthrax therapeutics. Due to their simple and stable nature, VNAs should be amenable to genetic delivery or administration via respiratory routes. PMID:25564615

Physicians’ Use of Email With Patients: Factors Influencing Electronic Communication and Adherence to Best Practices

PubMed Central

Menachemi, Nir

2006-01-01

Background With the public’s increased use of the Internet, the use of email as a means of communication between patients and physicians will likely increase. Yet, despite evidence of increased interest by patients, email use by physicians for clinical care has been slow. Objective To examine the factors associated with physician-patient email, and report on the physicians’ adherence to recognized guidelines for email communication. Methods Cross-sectional survey (March–May, 2005) of all primary care physicians (n = 10253), and a 25% stratified, random sample of all ambulatory clinical specialists (n = 3954) in the state of Florida. Physicians were surveyed on email use with patients, adherence to recognized guidelines, and demographics. Results The 4203 physicians completed the questionnaire (a 28.2% participation rate). Of these, 689 (16.6%) had personally used email to communicate with patients. Only 120 (2.9%) used email with patients frequently. In univariate analysis, email use correlated with physician age (decreased use: age > 61; P = .014), race (decreased use: Asian background; P < .001), medical training (increased use: family medicine, P = .001; or surgical specialty, P = .007; but not internal medicine, P = .112), practice size (> 50 physicians, P < .001), and geographic location (urban 17.2% vs. rural, 7.9%; P < .001). Multivariate modeling showed that only practice size greater than 50 (OR = 1.94; 95% CI = 1.01-3.79) and Asian-American race (OR = 0.26; 95% CI = 0.14-0.49) were related to email use with patients. Remarkably, only 46 physicians (6.7%) adhered to at least half of the 13 selected guidelines for email communication. Conclusions This large survey of physicians, practicing in ambulatory settings, shows only modest advances in the adoption of email communication, and little adherence to recognized guidelines for email correspondence. Further efforts are required to educate both patients and physicians on the advantages and limitations of email communication, and to remove fiscal and legal barriers to its adoption. PMID:16585026

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.

PubMed

Moayeri, Mahtab; Leysath, Clinton E; Tremblay, Jacqueline M; Vrentas, Catherine; Crown, Devorah; Leppla, Stephen H; Shoemaker, Charles B

2015-03-06

Anthrax disease is caused by a toxin consisting of protective antigen (PA), lethal factor, and edema factor. Antibodies against PA have been shown to be protective against the disease. Variable domains of camelid heavy chain-only antibodies (VHHs) with affinity for PA were obtained from immunized alpacas and screened for anthrax neutralizing activity in macrophage toxicity assays. Two classes of neutralizing VHHs were identified recognizing distinct, non-overlapping epitopes. One class recognizes domain 4 of PA at a well characterized neutralizing site through which PA binds to its cellular receptor. A second neutralizing VHH (JKH-C7) recognizes a novel epitope. This antibody inhibits conversion of the PA oligomer from "pre-pore" to its SDS and heat-resistant "pore" conformation while not preventing cleavage of full-length 83-kDa PA (PA83) by cell surface proteases to its oligomer-competent 63-kDa form (PA63). The antibody prevents endocytosis of the cell surface-generated PA63 subunit but not preformed PA63 oligomers formed in solution. JKH-C7 and the receptor-blocking VHH class (JIK-B8) were expressed as a heterodimeric VHH-based neutralizing agent (VNA2-PA). This VNA displayed improved neutralizing potency in cell assays and protected mice from anthrax toxin challenge with much better efficacy than the separate component VHHs. The VNA protected virtually all mice when separately administered at a 1:1 ratio to toxin and protected mice against Bacillus anthracis spore infection. Thus, our studies show the potential of VNAs as anthrax therapeutics. Due to their simple and stable nature, VNAs should be amenable to genetic delivery or administration via respiratory routes. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

46 CFR 1.03-35 - Appeals from decisions or actions of a recognized classification society acting on behalf of the...

Code of Federal Regulations, 2010 CFR

2010-10-01

... classification society acting on behalf of the Coast Guard. 1.03-35 Section 1.03-35 Shipping COAST GUARD... recognized classification society acting on behalf of the Coast Guard. (a) Any person directly affected by a decision or action of a recognized classification society performing plan review, tonnage measurement, or...

46 CFR 1.03-35 - Appeals from decisions or actions of a recognized classification society acting on behalf of the...

Code of Federal Regulations, 2011 CFR

2011-10-01

... classification society acting on behalf of the Coast Guard. 1.03-35 Section 1.03-35 Shipping COAST GUARD... recognized classification society acting on behalf of the Coast Guard. (a) Any person directly affected by a decision or action of a recognized classification society performing plan review, tonnage measurement, or...

26 CFR 1.1374-4 - Recognized built-in gain or loss.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Recognized built-in gain or loss. 1.1374-4... built-in gain or loss. (a) Sales and exchanges—(1) In general. Section 1374(d)(3) or 1374(d)(4) applies to any gain or loss recognized during the recognition period in a transaction treated as a sale or...

Rewriting History: Historical Research With the Digital Plan

DTIC Science & Technology

2009-10-01

significant enough to warrant a change or further analysis of how cadets take notes. The simple nature of the digital pen, akin to writing with a pen on... significant . By the third week the larger the percentage of handwriting correctly recognized, the higher the performance rating for the pen. Related...the pen at all. The current data showed two significant correlations between percent of handwriting recognized and the factors of pen performance and

Unwanted pregnancy and induced abortion among young women 16-22 years old in Greece: a retrospective study of the risk factors.

PubMed

Salakos, N; Koumousidis, A; Bakalianou, K; Paltoglou, G; Kalampokas, T; Iavazzo, C

2010-01-01

Unwanted pregnancies and the subsequent induced abortions are common problems of our youths in modern Greece. The aim of this study was to recognize the risk factors of the problem in an effort to find the best possible solution out of this social dead end. We interviewed 1,320 young female individuals and analyzed their answers using statistical analysis. Several useful conclusions were reached concerning the forces that are involved in unwanted pregnancy/induced abortions. We have tried to underline the strategy to combat the problem. Sexual education and the proper use of contraception remain the essential tools in this effort.

Exploring family and community involvement to protect Thai youths from alcohol and illegal drug abuse.

PubMed

Wongtongkam, Nualnong; Ward, Paul Russell; Day, Andrew; Winefield, Anthony Harold

2015-01-01

Youth substance abuse is widely recognized as a major public health issue in Thailand. This study explores family and community risk and protective factors relevant to alcohol and illegal drug misuse in 1,778 Thai teenagers. Strong family attachment and a family history of antisocial behaviors were strongly associated with nearly all forms of substance abuse, with adjusted odds ratios ranging from 5.05 to 8.45. Community disorganization was strongly associated with self-reported substance use, although involvement in prosocial activities acted as a protective factor. The findings suggest that interventions that promote family cohesion and encourage community involvement may have considerable benefits in reducing substance abuse in Thai adolescents.

Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujiwara, Ryoichi, E-mail: fujiwarar@pharm.kitasato-u.ac.jp; Maruo, Yoshihiro; Chen, Shujuan

Newborns commonly develop physiological hyperbilirubinemia (also known as jaundice). With increased bilirubin levels being observed in breast-fed infants, breast-feeding has been recognized as a contributing factor for the development of neonatal hyperbilirubinemia. Bilirubin undergoes selective metabolism by UDP-glucuronosyltransferase (UGT) 1A1 and becomes a water soluble glucuronide. Although several factors such as gestational age, dehydration and weight loss, and increased enterohepatic circulation have been associated with breast milk-induced jaundice (BMJ), deficiency in UGT1A1 expression is a known cause of BMJ. It is currently believed that unconjugated bilirubin is metabolized mainly in the liver. However, recent findings support the concept that extrahepaticmore » tissues, such as small intestine and skin, contribute to bilirubin glucuronidation during the neonatal period. We will review the recent advances made towards understanding biological and molecular events impacting BMJ, especially regarding the role of extrahepatic UGT1A1 expression. - Highlights: • Breast-feeding can be a factor for the development of neonatal hyperbilirubinemia. • UDP-glucuronosyltransferase (UGT) 1A1 is the sole bilirubin-metabolizing enzyme. • Extrahepatic UGT1A1 plays an important role in bilirubin metabolism. • We discuss the potential mechanism of breast milk-induced neonatal jaundice.« less

The yeast genome may harbor hypoxia response elements (HRE).

PubMed

Ferreira, Túlio César; Hertzberg, Libi; Gassmann, Max; Campos, Elida Geralda

2007-01-01

The hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor activated when cells are submitted to hypoxia. The heterodimer is composed of two subunits, HIF-1alpha and the constitutively expressed HIF-1beta. During normoxia, HIF-1alpha is degraded by the 26S proteasome, but hypoxia causes HIF-1alpha to be stabilized, enter the nucleus and bind to HIF-1beta, thus forming the active complex. The complex then binds to the regulatory sequences of various genes involved in physiological and pathological processes. The specific regulatory sequence recognized by HIF-1 is the hypoxia response element (HRE) that has the consensus sequence 5'BRCGTGVBBB3'. Although the basic transcriptional regulation machinery is conserved between yeast and mammals, Saccharomyces cerevisiae does not express HIF-1 subunits. However, we hypothesized that baker's yeast has a protein analogous to HIF-1 which participates in the response to changes in oxygen levels by binding to HRE sequences. In this study we screened the yeast genome for HREs using probabilistic motif search tools. We described 24 yeast genes containing motifs with high probability of being HREs (p-value<0.1) and classified them according to biological function. Our results show that S. cerevisiae may harbor HREs and indicate that a transcription factor analogous to HIF-1 may exist in this organism.

Star Formation Histories of z ∼ 1 Galaxies in LEGA-C

NASA Astrophysics Data System (ADS)

Chauke, Priscilla; van der Wel, Arjen; Pacifici, Camilla; Bezanson, Rachel; Wu, Po-Feng; Gallazzi, Anna; Noeske, Kai; Straatman, Caroline; Muños-Mateos, Juan-Carlos; Franx, Marijn; Barišić, Ivana; Bell, Eric F.; Brammer, Gabriel B.; Calhau, Joao; van Houdt, Josha; Labbé, Ivo; Maseda, Michael V.; Muzzin, Adam; Rix, Hans-Walter; Sobral, David

2018-07-01

Using high-resolution spectra from the VLT Large Early Galaxy Astrophysics Census (LEGA-C) program, we reconstruct the star formation histories (SFHs) of 607 galaxies at redshifts z = 0.6–1.0 and stellar masses ≳1010 M ⊙ using a custom full spectrum fitting algorithm that incorporates the emcee and FSPS packages. We show that the mass-weighted age of a galaxy correlates strongly with stellar velocity dispersion (σ *) and ongoing star formation (SF) activity, with the stellar content in higher-σ * galaxies having formed earlier and faster. The SFHs of quiescent galaxies are generally consistent with passive evolution since their main SF epoch, but a minority show clear evidence of a rejuvenation event in their recent past. The mean age of stars in galaxies that are star-forming is generally significantly younger, with SF peaking after z < 1.5 for almost all star-forming galaxies in the sample: many of these still have either constant or rising SFRs on timescales >100 Myr. This indicates that z > 2 progenitors of z ∼ 1 star-forming galaxies are generally far less massive. Finally, despite considerable variance in the individual SFHs, we show that the current SF activity of massive galaxies (>L *) at z ∼ 1 correlates with SF levels at least 3 Gyr prior: SFHs retain “memory” on a large fraction of the Hubble time. Our results illustrate a novel approach to resolve the formation phase of galaxies, and, by identifying their individual evolutionary paths, one can connect progenitors and descendants across cosmic time. This is uniquely enabled by the high-quality continuum spectroscopy provided by the LEGA-C survey.

Report of the 1st Planning Workshop for CELSS Flight Experimentation

NASA Technical Reports Server (NTRS)

Tremor, John W.; Macelroy, Robert D.

1988-01-01

A workshop held March 23 and 24, 1987 to establish a base upon which a CELSS flight experiment program will be developed, is summarized. The kind of information necessary for productivity assessment was determined. In addition, generic experiments necessary to gather that information were identified and prioritized. General problems of hardware and equipment were defined. The need for the hardware to provide a stress-free environment, not only for productivity, but also to make more readily identifiable disturbing mission factors, was recognized.

Interstellar medium conditions in z 0.2 Lyman-break analogs

NASA Astrophysics Data System (ADS)

Contursi, A.; Baker, A. J.; Berta, S.; Magnelli, B.; Lutz, D.; Fischer, J.; Verma, A.; Nielbock, M.; Grácia Carpio, J.; Veilleux, S.; Sturm, E.; Davies, R.; Genzel, R.; Hailey-Dunsheath, S.; Herrera-Camus, R.; Janssen, A.; Poglitsch, A.; Sternberg, A.; Tacconi, L. J.

2017-10-01

We present an analysis of far-infrared (FIR) [CII] and [OI] fine structure line and continuum observations obtained with Herschel/PACS, and 12CO(1-0) observations obtained with the IRAM Plateau de Bure Interferometer, of Lyman-break analogs (LBAs) at z 0.2. The principal aim of this work is to determine the typical interstellar medium (ISM) properties of z 1-2 main sequence (MS) galaxies, with stellar masses between 109.5 and 1011M⊙, which are currently not easily detectable in all these lines even with ALMA and NOEMA. We perform PDR modeling and apply different infared diagnostics to derive the main physical parameters of the far-infrared (FIR)-emitting gas and dust and we compare the derived ISM properties to those of galaxies on and above the MS at different redshifts. We find that the ISM properties of LBAs are quite extreme (low gas temperature and high density and thermal pressure) with respect to those found in local normal spirals and more active local galaxies. LBAs have no [CII] deficit despite having the high specific star formation rates (sSFRs) typical of starbursts. Although LBAs lie above the local MS, we show that their ISM properties are more similar to those of high-redshift MS galaxies than of local galaxies above the main sequence. This data set represents an important reference for planning future ALMA [CII] observations of relatively low-mass MS galaxies at the epoch of the peak of the cosmic star formation.

An Inclination-Dependent IRX-beta Relation for Galaxies at z~1.5

NASA Astrophysics Data System (ADS)

Wang, Weichen; Kassin, Susan A.; Pacifici, Camilla; de la Vega, Alexander; Simons, Raymond C.; Barro, Guillermo; Gordon, Karl D.; Snyder, Gregory

2018-01-01

Star-forming galaxies near cosmic noon are substantially obscured by dust. Therefore, to measure galaxy star-formation rates (SFRs), it is crucial to accurately account for dust obscuration. This is usually done by measuring the slopes of spectra in the rest-frame ultraviolet (i.e., β). Another independent method is to measure the infrared excess IRX, defined as the ratio between infrared and ultraviolet luminosity. In this work, we present the discovery that the relation between IRX and β varies systematically with galaxy inclination at z~1.5. Edge-on galaxies are on average ~0.5 dex higher in IRX than face-on galaxies at fixed β. Furthermore, we find that the difference between SFR(UV+IR) and β-corrected SFR(UV) is correlated with inclination. Our finding is consistent with the study of local galaxies (Wild et al. 2011), where the dust attenuation curve is found to flatten with increasing inclination. We interpret our results using a picture where dust and young stars are spatially mixed. In this case, β is more sensitive to the optically-thin regions near the surface of galaxy disks. Therefore, compared to the case of face-on galaxies, β measures a smaller fraction of the total dust optical depth for the edge-on galaxies, whereas IRX always probes the total optical depth. We conclude that inclination must be taken into account when evaluating dust attenuation with β at high redshift.

Activation of the hypoxia-inducible factor 1α promotes myogenesis through the noncanonical Wnt pathway, leading to hypertrophic myotubes.

PubMed

Cirillo, Federica; Resmini, Giulia; Ghiroldi, Andrea; Piccoli, Marco; Bergante, Sonia; Tettamanti, Guido; Anastasia, Luigi

2017-05-01

Regeneration of skeletal muscle is a complex process that requires the activation of quiescent adult stem cells, called satellite cells, which are resident in hypoxic niches in the tissue. Hypoxia has been recognized as a key factor to maintain stem cells in an undifferentiated state. Herein we report that hypoxia plays a fundamental role also in activating myogenesis. In particular, we found that the activation of the hypoxia-inducible factor (HIF)-1α under hypoxia, in murine skeletal myoblasts, leads to activation of MyoD through the noncanonical Wnt/β-catenin pathway. Moreover, chemical inhibition of HIF-1α activity significantly reduces differentiation, thus confirming its crucial role in the process. Furthermore, hypoxia-preconditioned myoblasts, once induced to differentiate under normoxic conditions, tend to form hypertrophic myotubes. These results support the notion that hypoxia plays a pivotal role in activating the regeneration process by directly inducing myogenesis through HIF-1α. Although preliminary, these findings may suggest new perspective for novel therapeutic targets in the treatment of several muscle diseases.-Cirillo, F., Resmini, G., Ghiroldi, A., Piccoli, M., Bergante, S., Tettamanti, G., Anastasia, L. Activation of the hypoxia-inducible factor 1α promotes myogenesis through the noncanonical Wnt pathway, leading to hypertrophic myotubes. © FASEB.

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.

PubMed

Cuende, Julia; Liénart, Stéphanie; Dedobbeleer, Olivier; van der Woning, Bas; De Boeck, Gitte; Stockis, Julie; Huygens, Caroline; Colau, Didier; Somja, Joan; Delvenne, Philippe; Hannon, Muriel; Baron, Frédéric; Dumoutier, Laure; Renauld, Jean-Christophe; De Haard, Hans; Saunders, Michael; Coulie, Pierre G; Lucas, Sophie

2015-04-22

Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function contributes to cancer progression by inhibiting antitumor immune responses. Tregs exert contact-dependent inhibition of immune cells through the production of active transforming growth factor-β1 (TGF-β1). On the Treg cell surface, TGF-β1 is in an inactive form bound to membrane protein GARP and then activated by an unknown mechanism. We demonstrate that GARP is involved in this activation mechanism. Two anti-GARP monoclonal antibodies were generated that block the production of active TGF-β1 by human Tregs. These antibodies recognize a conformational epitope that requires amino acids GARP137-139 within GARP/TGF-β1 complexes. A variety of antibodies recognizing other GARP epitopes did not block active TGF-β1 production by Tregs. In a model of xenogeneic graft-versus-host disease in NSG mice, the blocking antibodies inhibited the immunosuppressive activity of human Tregs. These antibodies may serve as therapeutic tools to boost immune responses to infection or cancer via a mechanism of action distinct from that of currently available immunomodulatory antibodies. Used alone or in combination with tumor vaccines or antibodies targeting the CTLA4 or PD1/PD-L1 pathways, blocking anti-GARP antibodies may improve the efficiency of cancer immunotherapy. Copyright © 2015, American Association for the Advancement of Science.

53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark

PubMed Central

Fradet-Turcotte, Amélie; Canny, Marella D.; Escribano-Díaz, Cristina; Orthwein, Alexandre; Leung, Charles C.Y.; Huang, Hao; Landry, Marie-Claude; Kitevski-LeBlanc, Julianne; Noordermeer, Sylvie M.; Sicheri, Frank; Durocher, Daniel

2014-01-01

53BP1 (TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand break (DSB) repair by non-homologous end joining. To accomplish its function in DNA repair, 53BP1 accumulates at DSB sites downstream of the RNF168 ubiquitin ligase. How ubiquitin recruits 53BP1 to break sites remains enigmatic since its relocalization involves recognition of H4 Lys20 (H4K20) methylation by its Tudor domain. Here we elucidate how 53BP1 is recruited to the chromatin that flanks DSB sites. We show that 53BP1 recognizes mono-nucleosomes containing dimethylated H4K20 (H4K20me2) and H2A ubiquitylated on Lys15 (H2AK15ub), the latter being a product of RNF168 action on chromatin. 53BP1 binds to nucleosomes minimally as a dimer using its previously characterized methyl-lysine-binding Tudor domain and a C-terminal extension, termed the ubiquitylation-dependent recruitment (UDR) motif, which interacts with the epitope formed by H2AK15ub and its surrounding residues on the H2A tail. 53BP1 is therefore a bivalent histone modification reader that recognizes a histone “code” produced by DSB signaling. PMID:23760478

Tissular growth factors profile after teduglutide administration on an animal model of intestinal anastomosis.

PubMed

Costa, Beatriz Pinto; Gonçalves, Ana Cristina; Abrantes, Ana Margarida; Alves, Raquel; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena; Castro-Sousa, Francisco

2018-01-16

Teduglutide is an enterotrophic analogue of glucagon-like peptide-2, with an indirect and poorly understood mechanism of action, approved for the rehabilitation of short-bowel syndrome. This study aims to analyze the response of tissue growth factors to surgical injury and teduglutide administration on an animal model of intestinal anastomosis. Wistar rats (n = 59) were distributed into four groups: "ileal resection" or "laparotomy", each one subdivided into "postoperative teduglutide administration" or "no treatment"; and sacrificed at the third or the seventh day, with ileal sample harvesting. Gene expression of insulin-like growth factor 1 (Igf1), vascular endothelial growth factor a (Vegfa), transforming growth factor β1 (Tgfβ1), connective tissue growth factor (Ctgf), fibroblast growth factor 2 (Fgf2), fibroblast growth factor 7 (Fgf7), epidermal growth factor (Egf), heparin-binding epidermal-like growth factor (Hbegf), platelet-derived growth factor b (Pdgfb) and glucagon-like peptide 2 receptor (Glp2r)was studied by real-time polymerase chain reaction. Upregulation of Fgf7, Fgf2, Egf, Vegfaand Glp2rat the third day and of Pdgfat the seventh day was verified in the perianastomotic segment. Teduglutide administration was associated with higher fold-change of relative gene expression of Vegfa(3.6 ± 1.3 vs.1.9 ± 2.0, p = 0.0001), Hbegf(2.2 ± 2.3 vs. 1.1 ± 0.9, p = 0.001), Igf1(1.6 ± 7.6 vs. 0.9 ± 0.7, p = 0.002) and Ctgf(1.1 ± 2.1 vs. 0.6 ± 2.0, p = 0.013); and lower fold-change of Tgfβ1, Fgf7and Glp2r. Those results underscore the recognized role of Igf1and Hbegfas molecular mediators of the effects of teduglutide and suggest that other humoral factors, like Vegfand Ctgf, may also be relevant in the perioperative context. Induction of Vegfa, Igf1and Ctgfgene expressions might indicate a favorable influence of teduglutide on the intestinal anastomotic healing.

Predictive Factors for Death After Snake Envenomation in Myanmar.

PubMed

Aye, Kyi-Phyu; Thanachartwet, Vipa; Soe, Chit; Desakorn, Varunee; Chamnanchanunt, Supat; Sahassananda, Duangjai; Supaporn, Thanom; Sitprija, Visith

2018-06-01

Factors predictive for death from snake envenomation vary between studies, possibly due to variation in host genetic factors and venom composition. This study aimed to evaluate predictive factors for death from snake envenomation in Myanmar. A prospective study was performed among adult patients with snakebite admitted to tertiary hospitals in Yangon, Myanmar, from May 2015 to August 2016. Data including clinical variables and laboratory parameters, management, and outcomes were evaluated. Multivariate regression analysis was performed to evaluate factors predictive for death at the time of presentation to the hospital. Of the 246 patients with snake envenomation recruited into the study, 225 (92%) survived and 21 (8%) died during hospitalization. The snake species responsible for a bite was identified in 74 (30%) of the patients; the majority of bites were from Russell's vipers (63 patients, 85%). The independent factors predictive for death included 1) duration from bite to arrival at the hospital >1 h (odds ratio [OR]: 9.0, 95% confidence interval [CI]: 1.1-75.2; P=0.04); 2) white blood cell counts >20 ×10 3 cells·μL -1 (OR: 8.9, 95% CI: 2.3-33.7; P=0.001); and 3) the presence of capillary leakage (OR: 3.7, 95% CI: 1.2-11.2; P=0.02). A delay in antivenom administration >4 h increases risk of death (11/21 deaths). Patients who present with these independent predictive factors should be recognized and provided with early appropriate intervention to reduce the mortality rate among adults with snake envenomation in Myanmar. Copyright © 2018 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.

PubMed

Lee, Dong-Kee; Suh, Dongchul; Edenberg, Howard J; Hur, Man-Wook

2002-07-26

The POZ domain is a protein-protein interaction motif that is found in many transcription factors, which are important for development, oncogenesis, apoptosis, and transcription repression. We cloned the POZ domain transcription factor, FBI-1, that recognizes the cis-element (bp -38 to -22) located just upstream of the core Sp1 binding sites (bp -22 to +22) of the ADH5/FDH minimal promoter (bp -38 to +61) in vitro and in vivo, as revealed by electrophoretic mobility shift assay and chromatin immunoprecipitation assay. The ADH5/FDH minimal promoter is potently repressed by the FBI-1. Glutathione S-transferase fusion protein pull-down showed that the POZ domains of FBI-1, Plzf, and Bcl-6 directly interact with the zinc finger DNA binding domain of Sp1. DNase I footprinting assays showed that the interaction prevents binding of Sp1 to the GC boxes of the ADH5/FDH promoter. Gal4-POZ domain fusions targeted proximal to the GC boxes repress transcription of the Gal4 upstream activator sequence-Sp1-adenovirus major late promoter. Our data suggest that POZ domain represses transcription by interacting with Sp1 zinc fingers and by interfering with the DNA binding activity of Sp1.

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications.

PubMed

Belaidi, Elise; Morand, Jessica; Gras, Emmanuelle; Pépin, Jean-Louis; Godin-Ribuot, Diane

2016-12-01

Obstructive sleep apnea (OSA) is now recognized as an independent and important risk factor for cardiovascular diseases such as hypertension, coronary heart disease, heart failure and stroke. Clinical and experimental data have confirmed that intermittent hypoxia is a major contributor to these deleterious consequences. The repetitive occurrence of hypoxia-reoxygenation sequences generates significant amounts of free radicals, particularly in moderate to severe OSA patients. Moreover, in addition to hypoxia, reactive oxygen species (ROS) are potential inducers of the hypoxia inducible transcription factor-1 (HIF-1) that promotes the transcription of numerous adaptive genes some of which being deleterious for the cardiovascular system, such as the endothelin-1 gene. This review will focus on the involvement of the ROS-HIF-1-endothelin signaling pathway in OSA and intermittent hypoxia and discuss current and potential therapeutic approaches targeting this pathway to treat or prevent cardiovascular disease in moderate to severe OSA patients. Copyright © 2016 Elsevier Inc. All rights reserved.

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications

PubMed Central

Belaidi, Elise; Morand, Jessica; Gras, Emmanuelle; Pépin, Jean-Louis; Godin-Ribuot, Diane

2016-01-01

Obstructive sleep apnea (OSA) is now recognized as an independent and important risk factor for cardiovascular diseases such as hypertension, coronary heart disease, heart failure and stroke. Clinical and experimental data have confirmed that intermittent hypoxia is a major contributor to these deleterious consequences. The repetitive occurrence of hypoxia-reoxygenation sequences generates significant amounts of free radicals, particularly in moderate to severe OSA patients. Moreover, in addition to hypoxia, reactive oxygen species (ROS) are potential inducers of the hypoxia inducible transcription factor-1 (HIF-1) that promotes the transcription of numerous adaptive genes some of which being deleterious for the cardiovascular system, such as the endothelin-1 gene. This review will focus on the involvement of the ROS-HIF-1-endotelin signaling pathway in OSA and intermittent hypoxia and discuss current and potential therapeutic approaches targeting this pathway to treat or prevent cardiovascular disease in moderate to severe OSA patients. PMID:27492897

Prevalence of forced sex and associated factors among women and men in Kisumu, Kenya.

PubMed

Adudans, Maureen K; Montandon, Michele; Kwena, Zachary; Bukusi, Elizabeth A; Cohen, Craig R

2011-12-01

Sexual violence is a well-recognized global health problem, albeit with limited population-based data available from sub-Saharan Africa. We sought to measure the prevalence of forced sex in Kisumu, Kenya, and identify its associated factors. The data were drawn from a population-based cross-sectional survey. A two-stage sampling design was used: 40 clusters within Kisumu municipality were enumerated and households within each cluster selected by systematic random sampling. Demographic and sexual histories, including questions on forced sex, were collected privately using a structured questionnaire. The prevalence of forced sex was 13% (women) and 4.5% (men). After adjusting for age and cluster, forced sex among women was associated with transactional sex (OR 2.33; 95%CI 1.38-3.95), having more than two lifetime partners (OR 1.9; 95%CI 1.20-3.30), having postprimary education (OR 1.49; 95%CI 1.04-2.14) and a high economic status (OR 1.87; 95%CI 1.2-2.9). No factors were significantly associated with forced sex among the male respondents. Intimate partners were the most common perpetrators of forced sex among both women (50%) and men (62.1%). Forced sex prevention programs need to target the identified associated factors, and educate the public on the high rate of forced sex perpetrated by intimate partners.

Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis.

PubMed

Li, Mo; Bian, Chunjing; Yu, Xiaochun

2014-01-01

Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis. However, the molecular mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive. Here, we show the evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor in mitosis. The BRCT domain of ECT2 directly binds to PAR both in vitro and in vivo. We further found that α-tubulin is PARylated during mitosis. PARylation of α-tubulin is recognized by ECT2 and recruits ECT2 to mitotic spindle for completing mitosis. Taken together, our study reveals a novel mechanism by which PAR regulates mitosis.

Promoting Students' Attention to Argumentative Reasoning Patterns

ERIC Educational Resources Information Center

Cavagnetto, Andy R.; Kurtz, Kenneth J.

2016-01-01

Argument-based interventions in science education have largely been motivated by the perspective that students lack knowledge of argument. Recent studies, however, suggest that contextual factors influence students' argument quality. The authors hypothesize that a key limiting factor lies in students' abilities to recognize when to employ…

The Definition and Measurement of Reasoning.

ERIC Educational Resources Information Center

Northrop, Lois C.

The complex and multi-faceted nature of the cognitive process of reasoning is discussed. The factor-analytic history of the isolation and definition of the three most important currently recognized reasoning factors (general reasoning, induction, and logical or deductive reasoning) is traced through the psychometric literature, and the…

Complex of Fas-associated Factor 1 (FAF1) with Valosin-containing Protein (VCP)-Npl4-Ufd1 and Polyubiquitinated Proteins Promotes Endoplasmic Reticulum-associated Degradation (ERAD)*

PubMed Central

Lee, Jae-Jin; Park, Joon Kyu; Jeong, Jaeho; Jeon, Hyesung; Yoon, Jong-Bok; Kim, Eunice EunKyeong; Lee, Kong-Joo

2013-01-01

Fas-associated factor 1 (FAF1) is a ubiquitin receptor containing multiple ubiquitin-related domains including ubiquitin-associated (UBA), ubiquitin-like (UBL) 1, UBL2, and ubiquitin regulatory X (UBX). We previously showed that N-terminal UBA domain recognizes Lys48-ubiquitin linkage to recruit polyubiquitinated proteins and that a C-terminal UBX domain interacts with valosin-containing protein (VCP). This study shows that FAF1 interacts only with VCP complexed with Npl4-Ufd1 heterodimer, a requirement for the recruitment of polyubiquitinated proteins to UBA domain. Intriguingly, VCP association to C-terminal UBX domain regulates ubiquitin binding to N-terminal UBA domain without direct interaction between UBA and UBX domains. These interactions are well characterized by structural and biochemical analysis. VCP-Npl4-Ufd1 complex is known as the machinery required for endoplasmic reticulum-associated degradation. We demonstrate here that FAF1 binds to VCP-Npl4-Ufd1 complex via UBX domain and polyubiquitinated proteins via UBA domain to promote endoplasmic reticulum-associated degradation. PMID:23293021

On the Appearance of Thresholds in the Dynamical Model of Star Formation

NASA Astrophysics Data System (ADS)

Elmegreen, Bruce G.

2018-02-01

The Kennicutt–Schmidt (KS) relationship between the surface density of the star formation rate (SFR) and the gas surface density has three distinct power laws that may result from one model in which gas collapses at a fixed fraction of the dynamical rate. The power-law slope is 1 when the observed gas has a characteristic density for detection, 1.5 for total gas when the thickness is about constant as in the main disks of galaxies, and 2 for total gas when the thickness is regulated by self-gravity and the velocity dispersion is about constant, as in the outer parts of spirals, dwarf irregulars, and giant molecular clouds. The observed scaling of the star formation efficiency (SFR per unit CO) with the dense gas fraction (HCN/CO) is derived from the KS relationship when one tracer (HCN) is on the linear part and the other (CO) is on the 1.5 part. Observations of a threshold density or column density with a constant SFR per unit gas mass above the threshold are proposed to be selection effects, as are observations of star formation in only the dense parts of clouds. The model allows a derivation of all three KS relations using the probability distribution function of density with no thresholds for star formation. Failed galaxies and systems with sub-KS SFRs are predicted to have gas that is dominated by an equilibrium warm phase where the thermal Jeans length exceeds the Toomre length. A squared relation is predicted for molecular gas-dominated young galaxies.

The Host Galaxies of X-Ray Selected Active Galactic Nuclei to z - 2.5: Structure, Star-Formation and Their Relationships from CANDELS and Herschel/Pacs

NASA Technical Reports Server (NTRS)

Rosario, D.J.; McIntosh, D. H.; van der Wel, A.; Kartaltepe, J.; Lang, P.; Santini, P.; Wuyts, S.; Lutz, D.; Rafelski, M.; Villforth, C.;

DETECTION OF H i IN EMISSION IN THE LY α EMITTING GALAXY HARO 11

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pardy, Stephen A.; Cannon, John M.; Östlin, Göran

We present the first robust detection of H i 21 cm emission in the blue compact galaxy Haro 11 using the 100 m Robert C. Byrd Green Bank Telescope (GBT). Haro 11 is a luminous blue compact galaxy with emission in both Ly α and the Lyman continuum. We detect (5.1 ± 0.7 × 10{sup 8}) M {sub ⊙} of H i gas at an assumed distance of 88 Mpc, making this galaxy H i deficient compared to other local galaxies with similar optical properties. Given this small H i mass, Haro 11 has an elevated M{sub H2}/ M{sub Hi} ratio and a verymore » low gas fraction compared to most local galaxies, and contains twice as much mass in ionized hydrogen as in neutral hydrogen. The H i emission has a linewidth of 71 km s{sup −}1 and is offset 60 km s{sup −1} redward of the optical line center. It is undergoing a starburst after a recent merger that has elevated the star formation rate, and will deplete the gas supply in <0.2 Gyr. Although this starburst has elevated the star formation rate (SFR) compared to galaxies with similar H i masses and line widths, Haro 11 matches a trend of lower gas fractions toward higher SFRs and is below the general trend of increasing H i mass with increasing luminosity. Taken together, our results paint Haro 11 as a standard low-mass galaxy that is undergoing an unusually efficient star formation episode.« less

Insulin resistance, role of metformin and other non-insulin therapies in pediatric type 1 diabetes.

PubMed

Bacha, Fida; Klinepeter Bartz, Sara

2016-12-01

Type 1 diabetes mellitus (T1DM) in youth is a challenging chronic medical condition. Its management should address not only the glycemic control but also insulin resistance and cardiovascular disease risk factors which are increasingly recognized to be present in youth with TID. Current knowledge on the mechanisms of insulin resistance in T1DM is reviewed. The use of adjunctive therapies that are beneficial to achieve adequate glycemic control while mitigating the effects of insulin resistance are discussed with a focus on metformin therapy and an overview of other new pharmacologic agents. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Confidence level in venipuncture and knowledge on causes of in vitro hemolysis among healthcare professionals

PubMed Central

Milutinović, Dragana; Andrijević, Ilija; Ličina, Milijana; Andrijević, Ljiljana

2015-01-01

Introduction This study aimed to assess confidence level of healthcare professionals in venipuncture and their knowledge on the possible causes of in vitro hemolysis. Materials and methods A sample of 94 healthcare professionals (nurses and laboratory technicians) participated in this survey study. A four-section questionnaire was used as a research instrument comprising general information for research participants, knowledge on possible causes of in vitro hemolysis due to type of material used and venipuncture technique and specimen handling, as well as assessment of healthcare professionals’ confidence level in their own ability to perform first and last venipuncture. Results The average score on the knowledge test was higher in nurses’ than in laboratory technicians (8.11 ± 1.7, and 7.4 ± 1.5, respectively). The difference in average scores was statistically significant (P = 0.035) and Cohen’s d in the range of 0.4 indicates that there is a moderate difference on the knowledge test among the health care workers. Only 11/94 of healthcare professionals recognized that blood sample collection from cannula and evacuated tube is method which contributes most to the occurrence of in vitro hemolysis, whereas most risk factors affecting occurrence of in vitro hemolysis during venipuncture were recognized. There were no significant differences in mean score on the knowledge test in relation to the confidence level in venipuncture (P = 0.551). Conclusion Confidence level at last venipuncture among both profiles of healthcare staff was very high, but they showed insufficient knowledge about possible factors affecting hemolysis due to materials used in venipuncture compared with factors due to venipuncture technique and handling of blood sample. PMID:26527124

Epidemiological Study on the Involvements of Environmental Factors and Allergy in Child Mental Health Using the Autism Screening Questionnaire

ERIC Educational Resources Information Center

Shibata, Aki; Hitomi, Yoshiaki; Kambayashi, Yasuhiro; Hibino, Yuri; Yamazaki, Masami; Mitoma, Junko; Asakura, Hiroki; Hayashi, Koichi; Otaki, Naoto; Sagara, Takiko; Nakamura, Hiroyuki

2013-01-01

Although autism is now recognized as being very common (Buie et al., 2010) and as developing due to not only genetic but also environmental factors, there is insufficient epidemiological evidence on the relationship between autism and allergy. In this study, therefore, we attempted to clarify the association of environmental factors with autism…

Multilevel Factor Structure, Concurrent Validity, and Test-Retest Reliability of the High School Teacher Version of the Authoritative School Climate Survey

ERIC Educational Resources Information Center

Huang, Francis L.; Cornell, Dewey G.

2016-01-01

Although school climate has long been recognized as an important factor in the school improvement process, there are few psychometrically supported measures based on teacher perspectives. The current study replicated and extended the factor structure, concurrent validity, and test-retest reliability of the teacher version of the Authoritative…

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development

PubMed Central

Rutkowski, Timothy P.; Kohn, Anat; Sharma, Deepika; Ren, Yinshi; Mirando, Anthony J.

2016-01-01

ABSTRACT RBPjκ-dependent Notch signaling regulates multiple processes during cartilage development, including chondrogenesis, chondrocyte hypertrophy and cartilage matrix catabolism. Select members of the HES- and HEY-families of transcription factors are recognized Notch signaling targets that mediate specific aspects of Notch function during development. However, whether particular HES and HEY factors play any role(s) in the processes during cartilage development is unknown. Here, for the first time, we have developed unique in vivo genetic models and in vitro approaches demonstrating that the RBPjκ-dependent Notch targets HES1 and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy. HES1 and HES5 might have some overlapping function in these processes, although only HES5 directly regulates Sox9 transcription to coordinate cartilage development. HEY1 and HEYL play no discernable role in regulating chondrogenesis or chondrocyte hypertrophy, whereas none of the HES or HEY factors appear to mediate Notch regulation of cartilage matrix catabolism. This work identifies important candidates that might function as downstream mediators of Notch signaling both during normal skeletal development and in Notch-related skeletal disorders. PMID:27160681

Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.

PubMed

Han, Weinong; Ming, Mei; Zhao, Rui; Pi, Jingbo; Wu, Chunli; He, Yu-Ying

2012-05-25

Skin cancer is the most common cancer in the United States. Its major environmental risk factor is UVB radiation in sunlight. In response to UVB damage, epidermal keratinocytes activate a specific repair pathway, i.e. nucleotide excision repair, to remove UVB-induced DNA lesions. However, the regulation of UVB response is not fully understood. Here we show that the long isoform of the nuclear factor erythroid 2-related factor 1 (Nrf1, also called NFE2L1), a cytoprotective transcription factor critical for the expression of multiple antioxidant response element-dependent genes, plays an important role in the response of keratinocytes to UVB. Nrf1 loss sensitized keratinocytes to UVB-induced apoptosis by up-regulating the expression of the proapoptotic Bcl-2 family member Bik through reducing glutathione levels. Knocking down Bik reduced UVB-induced apoptosis in Nrf1-inhibited cells. In UVB-irradiated surviving cells, however, disruption of Nrf1 impaired nucleotide excision repair through suppressing the transcription of xeroderma pigmentosum C (XPC), a factor essential for initiating the global genome nucleotide excision repair by recognizing the DNA lesion and recruiting downstream factors. Nrf1 enhanced XPC expression by increasing glutathione availability but was independent of the transcription repressor of XPC. Adding XPC or glutathione restored the DNA repair capacity in Nrf1-inhibited cells. Finally, we demonstrate that Nrf1 levels are significantly reduced by UVB radiation in mouse skin and are lower in human skin tumors than in normal skin. These results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin.

46 CFR 164.019-17 - Recognized laboratory.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Recognized laboratory. 164.019-17 Section 164.019-17...: SPECIFICATIONS AND APPROVAL MATERIALS Personal Flotation Device Components § 164.019-17 Recognized laboratory. (a) General. A laboratory may be designated as a recognized laboratory under this subpart if it is— (1...

46 CFR 164.019-17 - Recognized laboratory.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Recognized laboratory. 164.019-17 Section 164.019-17...: SPECIFICATIONS AND APPROVAL MATERIALS Personal Flotation Device Components § 164.019-17 Recognized laboratory. (a) General. A laboratory may be designated as a recognized laboratory under this subpart if it is— (1...

46 CFR 30.10-57 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Recognized classification society-TB/ALL. 30.10-57 Section 30.10-57 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-57 Recognized classification society—TB/ALL. The term recognized classification society...

46 CFR 30.10-57 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Recognized classification society-TB/ALL. 30.10-57 Section 30.10-57 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-57 Recognized classification society—TB/ALL. The term recognized classification society...

46 CFR 30.10-57 - Recognized classification society-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Recognized classification society-TB/ALL. 30.10-57 Section 30.10-57 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-57 Recognized classification society—TB/ALL. The term recognized classification society...

Structures of the tRNA export factor in the nuclear and cytosolic states.

PubMed

Cook, Atlanta G; Fukuhara, Noemi; Jinek, Martin; Conti, Elena

2009-09-03

Transfer RNAs are among the most ubiquitous molecules in cells, central to decoding information from messenger RNAs on translating ribosomes. In eukaryotic cells, tRNAs are actively transported from their site of synthesis in the nucleus to their site of function in the cytosol. This is mediated by a dedicated nucleo-cytoplasmic transport factor of the karyopherin-beta family (Xpot, also known as Los1 in Saccharomyces cerevisiae). Here we report the 3.2 A resolution structure of Schizosaccharomyces pombe Xpot in complex with tRNA and RanGTP, and the 3.1 A structure of unbound Xpot, revealing both nuclear and cytosolic snapshots of this transport factor. Xpot undergoes a large conformational change on binding cargo, wrapping around the tRNA and, in particular, binding to the tRNA 5' and 3' ends. The binding mode explains how Xpot can recognize all mature tRNAs in the cell and yet distinguish them from those that have not been properly processed, thus coupling tRNA export to quality control.

Decomposing Differences in Medical Care Access Among Cancer Survivors by Race and Ethnicity

PubMed Central

Chen, Jie; Dagher, Rada K.; Holt, Cheryl L.; Thomas, Stephen B.

2014-01-01

More research is needed to identify significant factors that explain why minority cancer survivors ages 18-64 are more likely to delay or forgo care when compared with whites. Data were merged from the 2000-2011 National Health Interview Survey to identify 12,125 adult survivors who delayed care due to cost, organization and transportation barriers. The Fairlie decomposition technique was applied to explore contributing factors. Compared to whites, Hispanics were more likely to delay medical or treatment due to organizational barriers (OR: 1.38; p<.05) and African Americans were more likely to delay care due to transportation barriers (OR: 1.54; p<.05). Age, insurance, perceived health, comorbidity, nativity and year were leading factors that contributed to the disparities. While expanded insurance coverage through the Affordable Care Act is expected to increase access, it is important to recognize the role of organizational convenience and transportation in facilitating timely health services for survivors. PMID:24904178

Identification of zinc finger transcription factor EGR2 as a novel acetylated protein.

PubMed

Noritsugu, Kota; Ito, Akihiro; Nakao, Yoichi; Yoshida, Minoru

2017-08-05

EGR2 is a zinc finger transcription factor that regulates myelination in the peripheral nervous system and T cell anergy. The transcriptional activity of EGR2 is known to be regulated by its co-activators and/or co-repressors. Although the activity of transcription factors is generally regulated not only by interactions with co-regulators but also posttranslational modifications including acetylation, little is known about posttranslational modifications of EGR2. Here we show that EGR2 is a novel acetylated protein. Through immunoblotting analyses using an antibody that specifically recognizes the acetylated form of EGR2, CBP and p300 were identified as acetyltransferases, while HDAC6, 10 and SIRT1 were identified as deacetylases of EGR2. Although the NuRD complex containing HDAC1 and HDAC2 is known to associate with EGR2, the present study suggests that acetylation of EGR2 is regulated independently of NuRD. Copyright © 2017 Elsevier Inc. All rights reserved.

HIghMass—High H I Mass, H I-rich Galaxies at z ˜ 0: Combined H I and H2 Observations

NASA Astrophysics Data System (ADS)

Hallenbeck, Gregory; Huang, Shan; Spekkens, Kristine; Haynes, Martha P.; Giovanelli, Riccardo; Adams, Elizabeth A. K.; Brinchmann, Jarle; Carpenter, John; Chengalur, Jayaram; Hunt, Leslie K.; Masters, Karen L.; Saintonge, Amélie

2016-12-01

We present resolved {{H}} {{I}} and CO observations of three galaxies from the HIghMass sample, a sample of {{H}} {{I}}-massive ({M}{{H}{{I}}}\\gt {10}10 {M}⊙ ), gas-rich ({M}{{H}{{I}}} in the top 5% for their M *) galaxies identified in the ALFALFA survey. Despite their high gas fractions, these are not low-surface-brightness galaxies and have typical specific star formation rates (SFR/{M}* ) for their stellar masses. The three galaxies have normal SFRs for their {{{H}}}2 masses, but unusually short star formation efficiency scale lengths, indicating that the star formation bottleneck in these galaxies is in the conversion of {{H}} {{I}} to {{{H}}}2, not in converting {{{H}}}2 to stars. In addition, their dark matter spin parameters (λ) are above average, but not exceptionally high, suggesting that their star formation has been suppressed over cosmic time but is now becoming active, in agreement with prior Hα observations.

Implementation Plan for Qualification of Sodium-Cooled Fast Reactor Technology Information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moe, Wayne; Honma, George

This document identifies and discusses implementation elements that can be used to facilitate consistent and systematic evaluation processes relating to quality attributes of technical information (with focus on SFR technology) that will be used to support licensing of advanced reactor designs. Information may include, but is not limited to, design documents for SFRs, research-and-development (R&D) data and associated documents, test plans and associated protocols, operations and test data, international research data, technical reports, and information associated with past U.S. Nuclear Regulatory Commission (NRC) reviews of SFR designs. The approach for determining acceptability of test data, analysis, and/or other technical informationmore » is based on guidance provided in INL/EXT-15-35805, “Guidance on Evaluating Historic Technology Information for Use in Advanced Reactor Licensing.” The implementation plan can be adopted into a working procedure at each of the national laboratories performing data qualification, or by applicants seeking future license application for advanced reactor technology.« less

The IMACS Cluster Building Survey. I. Description of the Survey and Analysis Methods

NASA Technical Reports Server (NTRS)

Oemler Jr., Augustus; Dressler, Alan; Gladders, Michael G.; Rigby, Jane R.; Bai, Lei; Kelson, Daniel; Villanueva, Edward; Fritz, Jacopo; Rieke, George; Poggianti, Bianca M.;

Synthesis and characterization of carbon microsphere for extinguishing sodium fire

NASA Astrophysics Data System (ADS)

Snehalatha, V.; Ponraju, D.; Nashine, B. K.; Chellapandi, P.

2013-06-01

In Sodium cooled Fast breeder Reactors (SFRs), accidental leakage of liquid sodium leads to sodium fire. Carbon microsphere is a promising and novel extinguishant for sodium fire since it possesses high thermal conductivity, chemical inertness and excellent flow characteristics. Low density Carbon microsphere (CMS) with high thermal stability was successfully synthesized from functionalized styrene divinyl benzene copolymer by carbonization under inert atmosphere. Protocol for stepwise carbonization was developed by optimizing heating rate and time of heating. The synthesized CMS was characterized by Densimeter, Scanning Electron Microscope (SEM), Fourier Transfer Infra-Red spectroscopy (FTIR), Thermogravimetry (TG), X-ray Diffraction (XRD) and RAMAN spectroscopy. CMS thus obtained was spherical in shape having diameters ranging between 60 to 80μm with narrow size distribution. The smooth surface of CMS ensures its free flow characteristics. The yield of carbonization process was about 38%. The performance of CMS was tested on small scale sodium. This paper describes the development of carbon microsphere for extinguishing sodium fire and its characteristics.

Sampling methods for stellar masses and the mmax-Mecl relation in the starburst dwarf galaxy NGC 4214

NASA Astrophysics Data System (ADS)

Weidner, Carsten; Kroupa, Pavel; Pflamm-Altenburg, Jan

2014-07-01

It has been claimed in the recent literature that a non-trivial relation between the mass of the most-massive star, mmax, in a star cluster and its embedded star cluster mass (the mmax - Mecl relation) is falsified by observations of the most-massive stars and the Hα luminosity of young star clusters in the starburst dwarf galaxy NGC 4214. Here, it is shown by comparing the NGC 4214 results with observations from the Milky Way that NGC 4214 agrees very well with the predictions of the mmax - Mecl relation and with the integrated galactic stellar initial mass function theory. The difference in conclusions is based on a high degree of degeneracy between expectations from random sampling and those from the mmax - Mecl relation, but are also due to interpreting mmax as a truncation mass in a randomly sampled initial mass function. Additional analysis of galaxies with lower SFRs than those currently presented in the literature will be required to break this degeneracy.

Murine J774 Macrophages Recognize LPS/IFN-g, Non-CpG DNA or Two-CpG DNA-containing Sequences as Immunologically Distinct

PubMed Central

Crosby, Lynn; Casey, Warren; Morgan, Kevin; Ni, Hong; Yoon, Lawrence; Easton, Marilyn; Misukonis, Mary; Burleson, Gary; Ghosh, Dipak K.

2010-01-01

Specific bacterial lipopolysaccharides (LPS), IFN-γ, and unmethylated cytosine or guanosine-phosphorothioate containing DNAs (CpG) activate host immunity, influencing infectious responses. Macrophages detect, inactivate and destroy infectious particles, and synthetic CpG sequences invoke similar responses of the innate immune system. Previously, murine macrophage J774 cells treated with CpG induced the expression of nitric oxide synthase 2 (NOS2) and cyclo-oxygenase 2 (COX2) mRNA and protein. In this study murine J774 macrophages were exposed to vehicle, interferon γ + lipopolysaccharide (IFN-g/LPS), non-CpG (SAK1), or two-CpG sequence-containing DNA (SAK2) for 0–18 hr and gene expression changes measured. A large number of immunostimulatory and inflammatory changes were observed. SAK2 was a stronger activator of TNFα- and chemokine expression-related changes than LPS/IFN-g. Up regulation included tumor necrosis factor receptor superfamily genes (TNFRSF’s), IL-1 receptor signaling via stress-activated protein kinase (SAPK), NF-κB activation, hemopoietic maturation factors and sonic hedgehog/wingless integration site (SHH/Wnt) pathway genes. Genes of the TGF-β pathway were down regulated. In contrast, LPS/IFN-g -treated cells showed increased levels for TGF-β signaling genes, which may be linked to the observed up regulation of numerous collagens and down regulation of Wnt pathway genes. SAK1 produced distinct changes from LPS/IFN-g or SAK2. Therefore, J774 macrophages recognize LPS/IFN-g, non-CpG DNA or two-CpG DNA-containing sequences as immunologically distinct. PMID:20097302

Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes.

PubMed

Chu, Chih-Sheng; Lee, Kun-Tai; Cheng, Kai-Hong; Lee, Min-Yi; Kuo, Hsuan-Fu; Lin, Tsung-Hsien; Su, Ho-Ming; Voon, Wen-Chol; Sheu, Sheng-Hsiung; Lai, Wen-Ter

2012-03-07

Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by oxidative stress. We hypothesized that postchallenge proinflammatory and nitrosative responses after 75 g oral glucose tolerance tests (75 g-OGTT) might be associated with CAD in patients without previously recognized type 2 diabetes mellitus (T2DM). Serial changes of plasma glucose (PG), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nitrotyrosine levels were analyzed during 75 g-OGTT in 120 patients (81 male; age 62 ± 11 years) before coronary angiography. Patients were classified as normal (NGT; 42%), impaired (IGT; 34%) and diabetic (T2DM; 24%) glucose tolerance by 75 g-OGTT. Postchallenge hyperglycemia elicited TNF-α, IL-6 and nitrotyrosine levels time-dependently, and 2-hr median levels of TNF-α (7.1 versus 6.4 pg/ml; P < 0.05) and nitrotyrosine (1.01 versus 0.83 μmol/l; P < 0.05), but not IL-6 or PG, were significantly higher in patients with CAD in either IGT or T2DM groups. After adjusting risk factors and glucose tolerance status, 2-hr nitrotyrosine in highest quartiles (OR: 3.1, P < 0.05) remained an independent predictor of CAD by logistic regression analysis. These results highlight postchallenge proinflammatory and nitrosative responses by 75 g-OGTT, rather than hyperglycemia per se, are associated with CAD in patients without previous recognized diabetes.

The role of genetic (PON1 polymorphism) and environmental factors, especially physical activity, in antioxidant function of paraoxonase.

PubMed

Otocka-Kmiecik, Aneta; Orłowska-Majdak, Monika

2009-12-30

Paraoxonase 1 (PON1) is a member of a three-gene family (PON1, PON2, and PON3). PON1 activity dominates in human plasma. It is secreted from hepatic cells and is found in the circulation bound to high-density lipoproteins (HDLs). For many years it has been known only for its ability to hydrolyze organophosphate derivatives. More recently, PON1's antioxidant activity draws attention as the enzyme was described to prevent oxidation of lipoproteins by reactive oxygen species formed during oxidative stress. PON1 was also shown to hydrolyze atherogenic products of oxidative lipid modification such as phospholipid peroxides and cholesterol ester hydroperoxides. Some studies indicate that the enzyme presents a lipolactonase activity and hydrolyzes homocysteine thiolactone (HCTL). There is growing evidence as to PON1's protective role in atherosclerosis. Genetic (PON1 polymorphism) and environmental factors and lifestyle may influence PON1 blood concentration and biological activity. Among the many recognized factors accounting for lifestyle, physical activity plays an important role. Various, often opposite, effects on PON1 status are observed in regular training and single physical activities. The results of different studies are often contradictory. It may depend on the time, intensity, and frequency of physical activity. Additionally, it seems that the effects of physical activity on PON1 blood concentration and activity are modified by environmental and lifestyle factors as well as PON1 polymorphism.

Specific and Modular Binding Code for Cytosine Recognition in Pumilio/FBF (PUF) RNA-binding Domains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong, Shuyun; Wang, Yang; Cassidy-Amstutz, Caleb

2011-10-28

Pumilio/fem-3 mRNA-binding factor (PUF) proteins possess a recognition code for bases A, U, and G, allowing designed RNA sequence specificity of their modular Pumilio (PUM) repeats. However, recognition side chains in a PUM repeat for cytosine are unknown. Here we report identification of a cytosine-recognition code by screening random amino acid combinations at conserved RNA recognition positions using a yeast three-hybrid system. This C-recognition code is specific and modular as specificity can be transferred to different positions in the RNA recognition sequence. A crystal structure of a modified PUF domain reveals specific contacts between an arginine side chain and themore » cytosine base. We applied the C-recognition code to design PUF domains that recognize targets with multiple cytosines and to generate engineered splicing factors that modulate alternative splicing. Finally, we identified a divergent yeast PUF protein, Nop9p, that may recognize natural target RNAs with cytosine. This work deepens our understanding of natural PUF protein target recognition and expands the ability to engineer PUF domains to recognize any RNA sequence.« less