Why Is Marketing Education a Must for Engineers? A Manager's Viewpoint.

ERIC Educational Resources Information Center

Rammant, J-P.

1988-01-01

Discusses the application of marketing principles to a software house specializing in products for the construction industry. Concludes that service management and marketing insights are important factors for the successful growth of a company or service department. (YP)

Engineering growth factors for regenerative medicine applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, Aaron C.; Briquez, Priscilla S.; Hubbell, Jeffrey A.

Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in regenerative medicine applications, translation of growth factors into clinical treatments has been hindered by limitations including poor protein stability, low recombinant expression yield, and suboptimal efficacy. This review highlights current tools, technologies, and approaches to design integrated and effective growth factor-based therapies for regenerative medicine applications. The first section describes rational and combinatorial protein engineering approaches that have been utilized to improve growth factor stability, expression yield, biodistribution, and serum half-life, or alter their cell traffickingmore » behavior or receptor binding affinity. The second section highlights elegant biomaterial-based systems, inspired by the natural extracellular matrix milieu, that have been developed for effective spatial and temporal delivery of growth factors to cell surface receptors. Although appearing distinct, these two approaches are highly complementary and involve principles of molecular design and engineering to be considered in parallel when developing optimal materials for clinical applications.« less

Growth factor delivery for oral and periodontal tissue engineering

PubMed Central

Kaigler, Darnell; Cirelli, Joni A; Giannobile, William V

2008-01-01

The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. Growth factors are critical to the development, maturation, maintenance and repair of craniofacial tissues, as they establish an extracellular environment that is conducive to cell and tissue growth. Tissue-engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. These materials have been constructed into devices that can be used as vehicles for delivery of cells, growth factors and DNA. In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral- and tooth-supporting structures, namely the periodontium and alveolar bone. PMID:16948560

Universal Design: Process, Principles, and Applications

ERIC Educational Resources Information Center

Burgstahler, Sheryl

2009-01-01

Designing any product or environment involves the consideration of many factors, including aesthetics, engineering options, environmental issues, safety concerns, industry standards, and cost. Typically, designers focus their attention on the average user. In contrast, universal design (UD), according to the Center for Universal Design," is…

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XVIII, I--UNDERSTAND ENGINE GEARS AND GEARING PRINCIPLES, II--MACK INTER-AXLE POWER DIVIDER.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF DIESEL ENGINE GEARS AND GEARING PRINCIPLES AND THE OPERATING PRINCIPLES AND MAINTENANCE OF POWER DIVIDERS (GEAR BOXES) USED IN DIESEL ENGINE POWER TRANSMISSION. TOPICS ARE (1) THE PURPOSE OF THE ENGINE GEARS, (2) INSPECTING FOR GEAR FAILURES, (3) INSPECTING FOR SHAFT…

Introduction to tissue engineering and application for cartilage engineering.

PubMed

de Isla, N; Huseltein, C; Jessel, N; Pinzano, A; Decot, V; Magdalou, J; Bensoussan, D; Stoltz, J-F

2010-01-01

Tissue engineering is a multidisciplinary field that applies the principles of engineering, life sciences, cell and molecular biology toward the development of biological substitutes that restore, maintain, and improve tissue function. In Western Countries, tissues or cells management for clinical uses is a medical activity governed by different laws. Three general components are involved in tissue engineering: (1) reparative cells that can form a functional matrix; (2) an appropriate scaffold for transplantation and support; and (3) bioreactive molecules, such as cytokines and growth factors that will support and choreograph formation of the desired tissue. These three components may be used individually or in combination to regenerate organs or tissues. Thus the growing development of tissue engineering needs to solve four main problems: cells, engineering development, grafting and safety studies.

Universal Design in Postsecondary Education: Process, Principles, and Applications

ERIC Educational Resources Information Center

Burgstahler, Sheryl

2009-01-01

Designing any product or environment involves the consideration of many factors, including aesthetics, engineering options, environmental issues, safety concerns, industry standards, and cost. Typically, designers focus their attention on the average user. In contrast, universal design (UD), according to the Center for Universal Design, "is…

Human Factors Design Principles for Instrument Approach Procedure Charts. Volume 1. Readability

DTIC Science & Technology

1992-08-01

discovery of mechanical type (Spencer, 1969). Not surprisingly, there is a substantial body of research and accepted practice that addresses...Swey for Automotive Engieer ARP4032 (April, 1988). Human engineering considerations in the application of cobr to electronic aircmjl dLspkp. Warrenlale

Near-field three-terminal thermoelectric heat engine

NASA Astrophysics Data System (ADS)

Jiang, Jian-Hua; Imry, Yoseph

2018-03-01

We propose a near-field inelastic thermoelectric heat engine where quantum dots are used to effectively rectify the charge flow of photocarriers. The device converts near-field heat radiation into useful electrical power. Heat absorption and inelastic transport can be enhanced by introducing two continuous spectra separated by an energy gap. The thermoelectric transport properties of the heat engine are studied in the linear-response regime. Using a small band-gap semiconductor as the absorption material, we show that the device achieves very large thermopower and thermoelectric figure of merit, as well as considerable power factor. By analyzing thermal-photocarrier generation and conduction, we reveal that the Seebeck coefficient and the figure of merit have oscillatory dependence on the thickness of the vacuum gap. Meanwhile, the power factor, the charge, and thermal conductivity are significantly improved by near-field radiation. Conditions and guiding principles for powerful and efficient thermoelectric heat engines are discussed in details.

Green engineering education through a U.S. EPA/academia collaboration.

PubMed

Shonnard, David R; Allen, David T; Nguyen, Nhan; Austin, Sharon Weil; Hesketh, Robert

2003-12-01

The need to use resources efficiently and reduce environmental impacts of industrial products and processes is becoming increasingly important in engineering design; therefore, green engineering principles are gaining prominence within engineering education. This paper describes a general framework for incorporating green engineering design principles into engineering curricula, with specific examples for chemical engineering. The framework for teaching green engineering discussed in this paper mirrors the 12 Principles of Green Engineering proposed by Anastas and Zimmerman (Environ. Sci. Technol. 2003, 37, 94A-101A), especially in methods for estimating the hazardous nature of chemicals, strategies for pollution prevention, and approaches leading to efficient energy and material utilization. The key elements in green engineering education, which enlarge the "box" for engineering design, are environmental literacy, environmentally conscious design, and beyond-the-plant boundary considerations.

Reflexive Principlism as an Effective Approach for Developing Ethical Reasoning in Engineering.

PubMed

Beever, Jonathan; Brightman, Andrew O

2016-02-01

An important goal of teaching ethics to engineering students is to enhance their ability to make well-reasoned ethical decisions in their engineering practice: a goal in line with the stated ethical codes of professional engineering organizations. While engineering educators have explored a wide range of methodologies for teaching ethics, a satisfying model for developing ethical reasoning skills has not been adopted broadly. In this paper we argue that a principlist-based approach to ethical reasoning is uniquely suited to engineering ethics education. Reflexive Principlism is an approach to ethical decision-making that focuses on internalizing a reflective and iterative process of specification, balancing, and justification of four core ethical principles in the context of specific cases. In engineering, that approach provides structure to ethical reasoning while allowing the flexibility for adaptation to varying contexts through specification. Reflexive Principlism integrates well with the prevalent and familiar methodologies of reasoning within the engineering disciplines as well as with the goals of engineering ethics education.

Design principles for therapeutic angiogenic materials

NASA Astrophysics Data System (ADS)

Briquez, Priscilla S.; Clegg, Lindsay E.; Martino, Mikaël M.; Gabhann, Feilim Mac; Hubbell, Jeffrey A.

2016-01-01

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis — the process of blood-vessel growth from existing vasculature — is regulated by a complex interplay of biophysical and biochemical cues from the extracellular matrix (ECM), angiogenic factors and multiple cell types. The ECM can be regarded as the natural 3D material that regulates angiogenesis. Here, we leverage knowledge of ECM properties to derive design rules for engineering pro-angiogenic materials. We propose that pro-angiogenic materials should be biomimetic, incorporate angiogenic factors and mimic cooperative interactions between growth factors and the ECM. We highlight examples of material designs that demonstrate these principles and considerations for designing better angiogenic materials.

Model and Study on Cascade Control System Based on IGBT Chopping Control

NASA Astrophysics Data System (ADS)

Niu, Yuxin; Chen, Liangqiao; Wang, Shuwen

2018-01-01

Thyristor cascade control system has a wide range of applications in the industrial field, but the traditional cascade control system has some shortcomings, such as a low power factor, serious harmonic pollution. In this paper, not only analyzing its system structure and working principle, but also discussing the two main factors affecting the power factor. Chopping-control cascade control system, adopted a new power switching device IGBT, which could overcome traditional cascade control system’s two main drawbacks efficiently. The basic principle of this cascade control system is discussed in this paper and the model of speed control system is built by using MATLAB/Simulink software. Finally, the simulation results of the system shows that the system works efficiently. This system is worthy to be spread widely in engineering application.

Engineering management of large scale systems

NASA Technical Reports Server (NTRS)

Sanders, Serita; Gill, Tepper L.; Paul, Arthur S.

1989-01-01

The organization of high technology and engineering problem solving, has given rise to an emerging concept. Reasoning principles for integrating traditional engineering problem solving with system theory, management sciences, behavioral decision theory, and planning and design approaches can be incorporated into a methodological approach to solving problems with a long range perspective. Long range planning has a great potential to improve productivity by using a systematic and organized approach. Thus, efficiency and cost effectiveness are the driving forces in promoting the organization of engineering problems. Aspects of systems engineering that provide an understanding of management of large scale systems are broadly covered here. Due to the focus and application of research, other significant factors (e.g., human behavior, decision making, etc.) are not emphasized but are considered.

Principles of Sociology in Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Andrews, James G.; Larsen, Jordan A.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, often with different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated with all relevant information informing system decisions. Robert K. Merton studied the sociological principles of the sciences and the sociological principles he developed apply to systems engineering. Concepts such as specification of ignorance, common terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that should be employed by the systems engineer. In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, insider-outsider behavior, unintended consequences, and the self-fulfilling prophecy. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information. This also helps identify key sociological barriers to information flow through the organization. This paper will discuss this theoretical basis for the application of sociological principles to systems engineering.

Proceedings from the U.S. Army Corps of Engineers (USACE) and the National Oceanic and Atmospheric Administration (NOAA) Engineering With Nature Workshop

DTIC Science & Technology

2017-03-01

opportunities emerged. It will be essential to capture and share lessons learned as the two organizations plan and implement selected EWN projects...their top five or six opportunities and subsequently selected the two highest priorities. Each of the three breakout groups then worked together to...will ensure agency buy-in, establish local reference sites, and promote EWN principles. Site selection will include an iterative process that factors

Just Culture: A Foundation for Balanced Accountability and Patient Safety

PubMed Central

Boysen, Philip G.

2013-01-01

Background The framework of a just culture ensures balanced accountability for both individuals and the organization responsible for designing and improving systems in the workplace. Engineering principles and human factors analysis influence the design of these systems so they are safe and reliable. Methods Approaches for improving patient safety introduced here are (1) analysis of error, (2) specific tools to enhance safety, and (3) outcome engineering. Conclusion The just culture is a learning culture that is constantly improving and oriented toward patient safety. PMID:24052772

An Internal Review and Operational Trial of a Human Factors Engineering Self-Paced Course in Accordance with the Instructional Systems Development Process.

DTIC Science & Technology

1983-12-01

factors aspects of systems and equipments. 6. Identify the human factors principles which must be applied during the evaluation of a workspace and control...Curriculum Development Expert Questionnaires Three proven specialists in the field of curriculum evaluation who regularly apply the standards and criteria 67...which each terminal objective met each of the six criteria listed in Appendix E. Ordinal values ranging from 1 through 4, were applied to the verbal

Discriminative non-negative matrix factorization (DNMF) and its application to the fault diagnosis of diesel engine

NASA Astrophysics Data System (ADS)

Yang, Yong-sheng; Ming, An-bo; Zhang, You-yun; Zhu, Yong-sheng

2017-10-01

Diesel engines, widely used in engineering, are very important for the running of equipments and their fault diagnosis have attracted much attention. In the past several decades, the image based fault diagnosis methods have provided efficient ways for the diesel engine fault diagnosis. By introducing the class information into the traditional non-negative matrix factorization (NMF), an improved NMF algorithm named as discriminative NMF (DNMF) was developed and a novel imaged based fault diagnosis method was proposed by the combination of the DNMF and the KNN classifier. Experiments performed on the fault diagnosis of diesel engine were used to validate the efficacy of the proposed method. It is shown that the fault conditions of diesel engine can be efficiently classified by the proposed method using the coefficient matrix obtained by DNMF. Compared with the original NMF (ONMF) and principle component analysis (PCA), the DNMF can represent the class information more efficiently because the class characters of basis matrices obtained by the DNMF are more visible than those in the basis matrices obtained by the ONMF and PCA.

Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine

DOE PAGES

Martino, Mikael M.; Brkic, Sime; Bovo, Emmanuela; ...

2015-04-01

In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular,more » the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.« less

Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martino, Mikael M.; Brkic, Sime; Bovo, Emmanuela

In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular,more » the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.« less

Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martino, Mikael M.; Brkic, Sime; Bovo, Emmanuela

Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localizationmore » of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.« less

Gene therapy with growth factors for periodontal tissue engineering–A review

PubMed Central

Gupta, Shipra; Mahendra, Aneet

2012-01-01

The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. A challenge faced by periodontal therapy is the predictable regeneration of periodontal tissues lost as a consequence of disease. Growth factors are critical to the development, maturation, maintenance and repair of oral tissues as they establish an extra-cellular environment that is conducive to cell and tissue growth. Tissue engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. The aim of this paper is to review emerging periodontal therapies in the areas of materials science, growth factor biology and cell/gene therapy. Various such materials have been formulated into devices that can be used as vehicles for delivery of cells, growth factors and DNA. Different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral and tooth supporting structure. Key words: Periodontal disease, gene therapy, regeneration, tissue repair, growth factors, tissue engineering. PMID:22143705

Designing for Success: Developing Engineers Who Consider Universal Design Principles

ERIC Educational Resources Information Center

Bigelow, Kimberly Edginton

2012-01-01

Engineers must design for a diverse group of potential users of their products; however, engineering curricula rarely include an emphasis on universal design principles. This research article details the effectiveness of a design project implemented in a first-year engineering course in an effort to raise awareness of the need for engineers to be…

The Application of Tissue Engineering Procedures to Repair the Larynx

ERIC Educational Resources Information Center

Ringel, Robert L.; Kahane, Joel C.; Hillsamer, Peter J.; Lee, Annie S.; Badylak, Stephen F.

2006-01-01

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach.

PubMed

Jabbarzadeh, Ehsan; Starnes, Trevor; Khan, Yusuf M; Jiang, Tao; Wirtel, Anthony J; Deng, Meng; Lv, Qing; Nair, Lakshmi S; Doty, Steven B; Laurencin, Cato T

2008-08-12

One of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Efforts to induce vascular growth into tissue-engineered scaffolds have recently been dedicated to developing novel strategies to deliver specific biological factors that direct the recruitment of endothelial cell (EC) progenitors and their differentiation. The challenge, however, lies in orchestration of the cells, appropriate biological factors, and optimal factor doses. This study reports an approach as a step forward to resolving this dilemma by combining an ex vivo gene transfer strategy and EC transplantation. The utility of this approach was evaluated by using 3D poly(lactide-co-glycolide) (PLAGA) sintered microsphere scaffolds for bone tissue engineering applications. Our goal was achieved by isolation and transfection of adipose-derived stromal cells (ADSCs) with adenovirus encoding the cDNA of VEGF. We demonstrated that the combination of VEGF releasing ADSCs and ECs results in marked vascular growth within PLAGA scaffolds. We thereby delineate the potential of ADSCs to promote vascular growth into biomaterials.

Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy–cell transplantation approach

PubMed Central

Jabbarzadeh, Ehsan; Starnes, Trevor; Khan, Yusuf M.; Jiang, Tao; Wirtel, Anthony J.; Deng, Meng; Lv, Qing; Nair, Lakshmi S.; Doty, Steven B.; Laurencin, Cato T.

2008-01-01

One of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Efforts to induce vascular growth into tissue-engineered scaffolds have recently been dedicated to developing novel strategies to deliver specific biological factors that direct the recruitment of endothelial cell (EC) progenitors and their differentiation. The challenge, however, lies in orchestration of the cells, appropriate biological factors, and optimal factor doses. This study reports an approach as a step forward to resolving this dilemma by combining an ex vivo gene transfer strategy and EC transplantation. The utility of this approach was evaluated by using 3D poly(lactide-co-glycolide) (PLAGA) sintered microsphere scaffolds for bone tissue engineering applications. Our goal was achieved by isolation and transfection of adipose-derived stromal cells (ADSCs) with adenovirus encoding the cDNA of VEGF. We demonstrated that the combination of VEGF releasing ADSCs and ECs results in marked vascular growth within PLAGA scaffolds. We thereby delineate the potential of ADSCs to promote vascular growth into biomaterials. PMID:18678895

Biomechanics and mechanobiology in functional tissue engineering

PubMed Central

Guilak, Farshid; Butler, David L.; Goldstein, Steven A.; Baaijens, Frank P.T.

2014-01-01

The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway. However, specific challenges still remain in the repair or regeneration of tissues that serve a predominantly biomechanical function. Furthermore, it is now clear that mechanobiological interactions between cells and scaffolds can critically influence cell behavior, even in tissues and organs that do not serve an overt biomechanical role. Over the past decade, the field of “functional tissue engineering” has grown as a subfield of tissue engineering to address the challenges and questions on the role of biomechanics and mechanobiology in tissue engineering. Originally posed as a set of principles and guidelines for engineering of load-bearing tissues, functional tissue engineering has grown to encompass several related areas that have proven to have important implications for tissue repair and regeneration. These topics include measurement and modeling of the in vivo biomechanical environment; quantitative analysis of the mechanical properties of native tissues, scaffolds, and repair tissues; development of rationale criteria for the design and assessment of engineered tissues; investigation of the effects biomechanical factors on native and repair tissues, in vivo and in vitro; and development and application of computational models of tissue growth and remodeling. Here we further expand this paradigm and provide examples of the numerous advances in the field over the past decade. Consideration of these principles in the design process will hopefully improve the safety, efficacy, and overall success of engineered tissue replacements. PMID:24818797

Inductive knowledge acquisition experience with commercial tools for space shuttle main engine testing

NASA Technical Reports Server (NTRS)

Modesitt, Kenneth L.

1990-01-01

Since 1984, an effort has been underway at Rocketdyne, manufacturer of the Space Shuttle Main Engine (SSME), to automate much of the analysis procedure conducted after engine test firings. Previously published articles at national and international conferences have contained the context of and justification for this effort. Here, progress is reported in building the full system, including the extensions of integrating large databases with the system, known as Scotty. Inductive knowledge acquisition has proven itself to be a key factor in the success of Scotty. The combination of a powerful inductive expert system building tool (ExTran), a relational data base management system (Reliance), and software engineering principles and Computer-Assisted Software Engineering (CASE) tools makes for a practical, useful and state-of-the-art application of an expert system.

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

Green Engineering Principle #4 Maximize Efficiency

EPA Science Inventory

As one reads the twelve principles of Green Engineering, there is one message that stands out and becomes ever increasingly more evident with each principle. Moreover, that message is simplicity! It is simplicity that will allow us, as a society, to become more sustainable.Althou...

Biomechanics and mechanobiology in functional tissue engineering.

PubMed

Guilak, Farshid; Butler, David L; Goldstein, Steven A; Baaijens, Frank P T

2014-06-27

The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway. However, specific challenges still remain in the repair or regeneration of tissues that serve a predominantly biomechanical function. Furthermore, it is now clear that mechanobiological interactions between cells and scaffolds can critically influence cell behavior, even in tissues and organs that do not serve an overt biomechanical role. Over the past decade, the field of "functional tissue engineering" has grown as a subfield of tissue engineering to address the challenges and questions on the role of biomechanics and mechanobiology in tissue engineering. Originally posed as a set of principles and guidelines for engineering of load-bearing tissues, functional tissue engineering has grown to encompass several related areas that have proven to have important implications for tissue repair and regeneration. These topics include measurement and modeling of the in vivo biomechanical environment; quantitative analysis of the mechanical properties of native tissues, scaffolds, and repair tissues; development of rationale criteria for the design and assessment of engineered tissues; investigation of the effects biomechanical factors on native and repair tissues, in vivo and in vitro; and development and application of computational models of tissue growth and remodeling. Here we further expand this paradigm and provide examples of the numerous advances in the field over the past decade. Consideration of these principles in the design process will hopefully improve the safety, efficacy, and overall success of engineered tissue replacements. Copyright © 2014 Elsevier Ltd. All rights reserved.

Showcasing Chemical Engineering Principles through the Production of Biodiesel from Spent Coffee Grounds

ERIC Educational Resources Information Center

Bendall, Sophie; Birdsall-Wilson, Max; Jenkins, Rhodri; Chew, Y. M. John; Chuck, Christopher J.

2015-01-01

Chemical engineering is rarely encountered before higher-level education in the U.S. or in Europe, leaving prospective students unaware of what an applied chemistry or chemical engineering degree entails. In this lab experiment, we report the implementation of a three-day course to showcase chemical engineering principles for 16-17 year olds…

Concise Review: Organ Engineering: Design, Technology, and Integration.

PubMed

Kaushik, Gaurav; Leijten, Jeroen; Khademhosseini, Ali

2017-01-01

Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed. Stem Cells 2017;35:51-60. © 2016 AlphaMed Press.

Applying human factors principles to alert design increases efficiency and reduces prescribing errors in a scenario-based simulation

PubMed Central

Russ, Alissa L; Zillich, Alan J; Melton, Brittany L; Russell, Scott A; Chen, Siying; Spina, Jeffrey R; Weiner, Michael; Johnson, Elizabette G; Daggy, Joanne K; McManus, M Sue; Hawsey, Jason M; Puleo, Anthony G; Doebbeling, Bradley N; Saleem, Jason J

2014-01-01

Objective To apply human factors engineering principles to improve alert interface design. We hypothesized that incorporating human factors principles into alerts would improve usability, reduce workload for prescribers, and reduce prescribing errors. Materials and methods We performed a scenario-based simulation study using a counterbalanced, crossover design with 20 Veterans Affairs prescribers to compare original versus redesigned alerts. We redesigned drug–allergy, drug–drug interaction, and drug–disease alerts based upon human factors principles. We assessed usability (learnability of redesign, efficiency, satisfaction, and usability errors), perceived workload, and prescribing errors. Results Although prescribers received no training on the design changes, prescribers were able to resolve redesigned alerts more efficiently (median (IQR): 56 (47) s) compared to the original alerts (85 (71) s; p=0.015). In addition, prescribers rated redesigned alerts significantly higher than original alerts across several dimensions of satisfaction. Redesigned alerts led to a modest but significant reduction in workload (p=0.042) and significantly reduced the number of prescribing errors per prescriber (median (range): 2 (1–5) compared to original alerts: 4 (1–7); p=0.024). Discussion Aspects of the redesigned alerts that likely contributed to better prescribing include design modifications that reduced usability-related errors, providing clinical data closer to the point of decision, and displaying alert text in a tabular format. Displaying alert text in a tabular format may help prescribers extract information quickly and thereby increase responsiveness to alerts. Conclusions This simulation study provides evidence that applying human factors design principles to medication alerts can improve usability and prescribing outcomes. PMID:24668841

Applying human factors principles to alert design increases efficiency and reduces prescribing errors in a scenario-based simulation.

PubMed

Russ, Alissa L; Zillich, Alan J; Melton, Brittany L; Russell, Scott A; Chen, Siying; Spina, Jeffrey R; Weiner, Michael; Johnson, Elizabette G; Daggy, Joanne K; McManus, M Sue; Hawsey, Jason M; Puleo, Anthony G; Doebbeling, Bradley N; Saleem, Jason J

2014-10-01

To apply human factors engineering principles to improve alert interface design. We hypothesized that incorporating human factors principles into alerts would improve usability, reduce workload for prescribers, and reduce prescribing errors. We performed a scenario-based simulation study using a counterbalanced, crossover design with 20 Veterans Affairs prescribers to compare original versus redesigned alerts. We redesigned drug-allergy, drug-drug interaction, and drug-disease alerts based upon human factors principles. We assessed usability (learnability of redesign, efficiency, satisfaction, and usability errors), perceived workload, and prescribing errors. Although prescribers received no training on the design changes, prescribers were able to resolve redesigned alerts more efficiently (median (IQR): 56 (47) s) compared to the original alerts (85 (71) s; p=0.015). In addition, prescribers rated redesigned alerts significantly higher than original alerts across several dimensions of satisfaction. Redesigned alerts led to a modest but significant reduction in workload (p=0.042) and significantly reduced the number of prescribing errors per prescriber (median (range): 2 (1-5) compared to original alerts: 4 (1-7); p=0.024). Aspects of the redesigned alerts that likely contributed to better prescribing include design modifications that reduced usability-related errors, providing clinical data closer to the point of decision, and displaying alert text in a tabular format. Displaying alert text in a tabular format may help prescribers extract information quickly and thereby increase responsiveness to alerts. This simulation study provides evidence that applying human factors design principles to medication alerts can improve usability and prescribing outcomes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Profile of an Effective Engineering Manager at the Naval Avionics Center

DTIC Science & Technology

1991-06-01

GROUP Leadership ; Engineering Management Effectiveness; Engineers; Engineering Managers ; Naval Avionics Center 19 ABSTR. T (Continue on reverse if...Personnel. The purpose of the Institute is to support the implementation of the NAC Leadership / Management Principles throughout NAC. The Leadership ... Management Principles are as follows: - Develc 2 and Maintain a Corporate Outlook. - Communicate the Organizational Vision through Positive Leadership

Ambulatory Antibiotic Stewardship through a Human Factors Engineering Approach: A Systematic Review.

PubMed

Keller, Sara C; Tamma, Pranita D; Cosgrove, Sara E; Miller, Melissa A; Sateia, Heather; Szymczak, Julie; Gurses, Ayse P; Linder, Jeffrey A

2018-01-01

In the United States, most antibiotics are prescribed in ambulatory settings. Human factors engineering, which explores interactions between people and the place where they work, has successfully improved quality of care. However, human factors engineering models have not been explored to frame what is known about ambulatory antibiotic stewardship (AS) interventions and barriers and facilitators to their implementation. We conducted a systematic review and searched OVID MEDLINE, Embase, Scopus, Web of Science, and CINAHL to identify controlled interventions and qualitative studies of ambulatory AS and determine whether and how they incorporated principles from a human factors engineering model, the Systems Engineering Initiative for Patient Safety 2.0 model. This model describes how a work system (ambulatory clinic) contributes to a process (antibiotic prescribing) that leads to outcomes. The work system consists of 5 components, tools and technology, organization, person, tasks, and environment, within an external environment. Of 1,288 abstracts initially identified, 42 quantitative studies and 17 qualitative studies met inclusion criteria. Effective interventions focused on tools and technology (eg, clinical decision support and point-of-care testing), the person (eg, clinician education), organization (eg, audit and feedback and academic detailing), tasks (eg, delayed antibiotic prescribing), the environment (eg, commitment posters), and the external environment (media campaigns). Studies have not focused on clinic-wide approaches to AS. A human factors engineering approach suggests that investigating the role of the clinic's processes or physical layout or external pressures' role in antibiotic prescribing may be a promising way to improve ambulatory AS. © Copyright 2018 by the American Board of Family Medicine.

An economic analysis of adherence engineering to improve use of best practices during central line maintenance procedures.

PubMed

Nelson, Richard E; Angelovic, Aaron W; Nelson, Scott D; Gleed, Jeremy R; Drews, Frank A

2015-05-01

Adherence engineering applies human factors principles to examine non-adherence within a specific task and to guide the development of materials or equipment to increase protocol adherence and reduce human error. Central line maintenance (CLM) for intensive care unit (ICU) patients is a task through which error or non-adherence to protocols can cause central line-associated bloodstream infections (CLABSIs). We conducted an economic analysis of an adherence engineering CLM kit designed to improve the CLM task and reduce the risk of CLABSI. We constructed a Markov model to compare the cost-effectiveness of the CLM kit, which contains each of the 27 items necessary for performing the CLM procedure, compared with the standard care procedure for CLM, in which each item for dressing maintenance is gathered separately. We estimated the model using the cost of CLABSI overall ($45,685) as well as the excess LOS (6.9 excess ICU days, 3.5 excess general ward days). Assuming the CLM kit reduces the risk of CLABSI by 100% and 50%, this strategy was less costly (cost savings between $306 and $860) and more effective (between 0.05 and 0.13 more quality-adjusted life-years) compared with not using the pre-packaged kit. We identified threshold values for the effectiveness of the kit in reducing CLABSI for which the kit strategy was no longer less costly. An adherence engineering-based intervention to streamline the CLM process can improve patient outcomes and lower costs. Patient safety can be improved by adopting new approaches that are based on human factors principles.

Principles and Experience of the On-Condition Application of Oils and Working Fluids to Aeronautical Engineering

DTIC Science & Technology

1996-04-01

structural factors; I is the temperature, p is the pressure; P, is the vibration parameter; Q, is the supply amount (volume); R, is the supply rate; If is...Bueiu6, Aires, Argentina, p. 4, 1994. 3. B.Bedrik, M.Yampolsky "Study and procedure of oils application in aeroengines according to the condition. Joint

New Principles and Basic Approaches for the Curricula of Engineering Degree Courses.

ERIC Educational Resources Information Center

Gargione, Luiz Antonio

This paper presents new principles and basic approaches for the curricula of engineering degree courses. The accentuated evolution of engineering, the fast technological transformations and, still, the impact provoked by government regulations in the field of education in Brazil have called attention to these issues. Following these changes, it…

Developing a Dynamics and Vibrations Course for Civil Engineering Students Based on Fundamental-Principles

ERIC Educational Resources Information Center

Barroso, Luciana R.; Morgan, James R.

2012-01-01

This paper describes the creation and evolution of an undergraduate dynamics and vibrations course for civil engineering students. Incorporating vibrations into the course allows students to see and study "real" civil engineering applications of the course content. This connection of academic principles to real life situations is in…

Engineering Codes of Ethics and the Duty to Set a Moral Precedent.

PubMed

Schlossberger, Eugene

2016-10-01

Each of the major engineering societies has its own code of ethics. Seven "common core" clauses and several code-specific clauses can be identified. The paper articulates objections to and rationales for two clauses that raise controversy: do engineers have a duty (a) to provide pro bono services and/or speak out on major issues, and (b) to associate only with reputable individuals and organizations? This latter "association clause" can be justified by the "proclamative principle," an alternative to Kant's universalizability requirement. At the heart of engineering codes of ethics, and implicit in what it is to be a moral agent, the "proclamative principle" asserts that one's life should proclaim one's moral stances (one's values, principles, perceptions, etc.). More specifically, it directs engineers to strive to insure that their actions, thoughts, and relationships be fit to offer to their communities as part of the body of moral precedents for how to be an engineer. Understanding codes of ethics as reflections of this principle casts light both on how to apply the codes and on the distinction between private and professional morality.

The construction of life prediction models for the design of Stirling engine heater components

NASA Technical Reports Server (NTRS)

Petrovich, A.; Bright, A.; Cronin, M.; Arnold, S.

1983-01-01

The service life of Stirling-engine heater structures of Fe-based high-temperature alloys is predicted using a numerical model based on a linear-damage approach and published test data (engine test data for a Co-based alloy and tensile-test results for both the Co-based and the Fe-based alloys). The operating principle of the automotive Stirling engine is reviewed; the economic and technical factors affecting the choice of heater material are surveyed; the test results are summarized in tables and graphs; the engine environment and automotive duty cycle are characterized; and the modeling procedure is explained. It is found that the statistical scatter of the fatigue properties of the heater components needs to be reduced (by decreasing the porosity of the cast material or employing wrought material in fatigue-prone locations) before the accuracy of life predictions can be improved.

Using Green Chemistry and Engineering Principles to Design ...

EPA Pesticide Factsheets

The concepts of green chemistry and engineering (GC&E) have been promoted as an effective qualitative framework for developing more sustainable chemical syntheses, processes, and material management techniques. This has been demonstrated by many theoretical and practical cases. In addition, there are several approaches and frameworks focused on demonstrating that improvements were achieved through GC&E technologies. However, the application of these principles is not always straightforward. We propose using systematic frameworks and tools that help practitioners when deciding which principles can be applied, the levels of implementation, prospective of obtaining simultaneous improvements in all sustainability aspects, and ways to deal with multiobjective problems. Therefore, this contribution aims to provide a systematic combination of three different and complementary design tools for assisting designers in evaluating, developing, and improving chemical manufacturing and material management systems under GC&E perspectives. The WAR Algorithm, GREENSCOPE, and SustainPro were employed for this synergistic approach of incorporating sustainability at early stages of process development. In this demonstration, simulated ammonia production is used as a case study to illustrate this advancement. Results show how to identify process design areas for improvements, key factors, multi-criteria decision-making solutions, and optimal tradeoffs. Finally, conclusions were pre

Organizational and Pedagogical Fundamentals of Professional Training of Engineers in the Field of Nanoelectronics in UK Universities

ERIC Educational Resources Information Center

Mykhailiuk, Maryna

2014-01-01

The article deals with the organizational and pedagogical principles of the professional training of future nanoelectronics engineers in UK universities. There has been substantiated a number of general didactic and specific principles of the professional training of future nanoelectronics engineers, which facilitate the concretization of content,…

Lessons Learned in Engineering

NASA Technical Reports Server (NTRS)

Blair, J. C.; Ryan, R. S.; Schutzenhofer, L. A.

2011-01-01

This Contractor Report (CR) is a compilation of Lessons Learned in approximately 55 years of engineering experience by each James C. Blair, Robert S. Ryan, and Luke A. Schutzenhofer. The lessons are the basis of a course on Lessons Learned that has been taught at Marshall Space Flight Center. The lessons are drawn from NASA space projects and are characterized in terms of generic lessons learned from the project experience, which are further distilled into overarching principles that can be applied to future projects. Included are discussions of the overarching principles followed by a listing of the lessons associated with that principle. The lesson with sub-lessons are stated along with a listing of the project problems the lesson is drawn from, then each problem is illustrated and discussed, with conclusions drawn in terms of Lessons Learned. The purpose of this CR is to provide principles learned from past aerospace experience to help achieve greater success in future programs, and identify application of these principles to space systems design. The problems experienced provide insight into the engineering process and are examples of the subtleties one experiences performing engineering design, manufacturing, and operations.

The telerobot workstation testbed for the shuttle aft flight deck: A project plan for integrating human factors into system design

NASA Technical Reports Server (NTRS)

Sauerwein, Timothy

1989-01-01

The human factors design process in developing a shuttle orbiter aft flight deck workstation testbed is described. In developing an operator workstation to control various laboratory telerobots, strong elements of human factors engineering and ergonomics are integrated into the design process. The integration of human factors is performed by incorporating user feedback at key stages in the project life-cycle. An operator centered design approach helps insure the system users are working with the system designer in the design and operation of the system. The design methodology is presented along with the results of the design and the solutions regarding human factors design principles.

Background and principles of throttles-only flight control

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.

1995-01-01

There have been many cases in which the crew of a multi-engine airplane had to use engine thrust for emergency flight control. Such a procedure is very difficult, because the propulsive control forces are small, the engine response is slow, and airplane dynamics such as the phugoid and dutch roll are difficult to damp with thrust. In general, thrust increases are used to climb, thrust decreases to descend, and differential thrust is used to turn. Average speed is not significantly affected by changes in throttle setting. Pitch control is achieved because of pitching moments due to speed changes, from thrust offset, and from the vertical component of thrust. Roll control is achieved by using differential thrust to develop yaw, which, through the normal dihedral effect, causes a roll. Control power in pitch and roll tends to increase as speed decreases. Although speed is not controlled by the throttles, configuration changes are often available (lowering gear, flaps, moving center-of-gravity) to change the speed. The airplane basic stability is also a significant factor. Fuel slosh and gyroscopic moments are small influences on throttles-only control. The background and principles of throttles-only flight control are described.

High frequency x-ray generator basics.

PubMed

Sobol, Wlad T

2002-02-01

The purpose of this paper is to present basic functional principles of high frequency x-ray generators. The emphasis is put on physical concepts that determine the engineering solutions to the problem of efficient generation and control of high voltage power required to drive the x-ray tube. The physics of magnetically coupled circuits is discussed first, as a background for the discussion of engineering issues related to high-frequency power transformer design. Attention is paid to physical processes that influence such factors as size, efficiency, and reliability of a high voltage power transformer. The basic electrical circuit of a high frequency generator is analyzed next, with focus on functional principles. This section investigates the role and function of basic components, such as power supply, inverter, and voltage doubler. Essential electronic circuits of generator control are then examined, including regulation of voltage, current and timing of electrical power delivery to the x-ray tube. Finally, issues related to efficient feedback control, including basic design of the AEC circuitry are reviewed.

Review paper: critical issues in tissue engineering: biomaterials, cell sources, angiogenesis, and drug delivery systems.

PubMed

Naderi, Hojjat; Matin, Maryam M; Bahrami, Ahmad Reza

2011-11-01

Tissue engineering is a newly emerging biomedical technology, which aids and increases the repair and regeneration of deficient and injured tissues. It employs the principles from the fields of materials science, cell biology, transplantation, and engineering in an effort to treat or replace damaged tissues. Tissue engineering and development of complex tissues or organs, such as heart, muscle, kidney, liver, and lung, are still a distant milestone in twenty-first century. Generally, there are four main challenges in tissue engineering which need optimization. These include biomaterials, cell sources, vascularization of engineered tissues, and design of drug delivery systems. Biomaterials and cell sources should be specific for the engineering of each tissue or organ. On the other hand, angiogenesis is required not only for the treatment of a variety of ischemic conditions, but it is also a critical component of virtually all tissue-engineering strategies. Therefore, controlling the dose, location, and duration of releasing angiogenic factors via polymeric delivery systems, in order to ultimately better mimic the stem cell niche through scaffolds, will dictate the utility of a variety of biomaterials in tissue regeneration. This review focuses on the use of polymeric vehicles that are made of synthetic and/or natural biomaterials as scaffolds for three-dimensional cell cultures and for locally delivering the inductive growth factors in various formats to provide a method of controlled, localized delivery for the desired time frame and for vascularized tissue-engineering therapies.

Synthetic Biology: Engineering Living Systems from Biophysical Principles.

PubMed

Bartley, Bryan A; Kim, Kyung; Medley, J Kyle; Sauro, Herbert M

2017-03-28

Synthetic biology was founded as a biophysical discipline that sought explanations for the origins of life from chemical and physical first principles. Modern synthetic biology has been reinvented as an engineering discipline to design new organisms as well as to better understand fundamental biological mechanisms. However, success is still largely limited to the laboratory and transformative applications of synthetic biology are still in their infancy. Here, we review six principles of living systems and how they compare and contrast with engineered systems. We cite specific examples from the synthetic biology literature that illustrate these principles and speculate on their implications for further study. To fully realize the promise of synthetic biology, we must be aware of life's unique properties. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

A CAL Program to Teach the Basic Principles of Genetic Engineering--A Change from the Traditional Approach.

ERIC Educational Resources Information Center

Dewhurst, D. G.; And Others

1989-01-01

An interactive computer-assisted learning program written for the BBC microcomputer to teach the basic principles of genetic engineering is described. Discussed are the hardware requirements software, use of the program, and assessment. (Author/CW)

Dental pulp stem cells. Biology and use for periodontal tissue engineering.

PubMed

Ashri, Nahid Y; Ajlan, Sumaiah A; Aldahmash, Abdullah M

2015-12-01

Inflammatory periodontal disease is a major cause of loss of tooth-supporting structures. Novel approaches for regeneration of periodontal apparatus is an area of intensive research. Periodontal tissue engineering implies the use of appropriate regenerative cells, delivered through a suitable scaffold, and guided through signaling molecules. Dental pulp stem cells have been used in an increasing number of studies in dental tissue engineering. Those cells show mesenchymal (stromal) stem cell-like properties including self-renewal and multilineage differentiation potentials, aside from their relative accessibility and pleasant handling properties. The purpose of this article is to review the biological principles of periodontal tissue engineering, along with the challenges facing the development of a consistent and clinically relevant tissue regeneration platform. This article includes an updated review on dental pulp stem cells and their applications in periodontal regeneration, in combination with different scaffolds and growth factors.

Quantum heat engine operating between thermal and spin reservoirs

NASA Astrophysics Data System (ADS)

Wright, Jackson S. S. T.; Gould, Tim; Carvalho, André R. R.; Bedkihal, Salil; Vaccaro, Joan A.

2018-05-01

Landauer's erasure principle is a cornerstone of thermodynamics and information theory [R. Landauer, IBM J. Res. Dev. 5, 183 (1961), 10.1147/rd.53.0183]. According to this principle, erasing information incurs a minimum energy cost. Recently, Vaccaro and Barnett [J. A. Vaccaro and S. M. Barnett, Proc. R. Soc. A 467, 1770 (2011), 10.1098/rspa.2010.0577] explored information erasure in the context of multiple conserved quantities and showed that the erasure cost can be solely in terms of spin angular momentum. As Landauer's erasure principle plays a fundamental role in heat engines, their result considerably widens the possible configurations that heat engines can have. Motivated by this, we propose here an optical heat engine that operates under a single thermal reservoir and a spin angular momentum reservoir coupled to a three-level system with two energy degenerate ground states. The proposed heat engine operates without producing waste heat and goes beyond the traditional Carnot engine where the working fluid is subjected to two thermal baths at different temperatures.

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Briquez, Priscilla S.; Hubbell, Jeffrey A.; Martino, Mikaël M.

2015-08-01

Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localizationmore » of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.« less

Laser identification system based on acousto-optical barcode scanner principles

NASA Astrophysics Data System (ADS)

Khansuvarov, Ruslan A.; Korol, Georgy I.; Preslenev, Leonid N.; Bestugin, Aleksandr R.; Paraskun, Arthur S.

2016-09-01

The main purpose of the bar code in the modern world is the unique identification of the product, service, or any of their features, so personal and stationary barcode scanners so widely used. One of the important parameters of bar code scanners is their reliability, accuracy of the barcode recognition, response time and performance. Nowadays, the most popular personal barcode scanners contain a mechanical part, which extremely impairs the reliability indices. Group of SUAI engineers has proposed bar code scanner based on laser beam acoustic deflection effect in crystals [RU patent No 156009 issued 4/16/2015] Through the use of an acousto-optic deflector element in barcode scanner described by a group of engineers SUAI, it can be implemented in the manual form factor, and the stationary form factor of a barcode scanner. Being a wave electronic device, an acousto-optic element in the composition of the acousto-optic barcode scanner allows you to clearly establish a mathematical link between the encoded function of the bar code with the accepted input photodetector intensities function that allows you to speak about the great probability of a bar code clear definition. This paper provides a description of the issued patent, the description of the principles of operation based on the mathematical analysis, a description of the layout of the implemented scanner.

Global challenges as inspiration: a classroom strategy to foster social responsibility.

PubMed

Vanasupa, Linda; Slivovsky, Lynn; Chen, Katherine C

2006-04-01

Social responsibility is at the heart of the Engineer's Creed embodied in the pledge that we will dedicate [our] professional knowledge and skill to the advancement and betterment of human welfare... [placing] public welfare above all other considerations. However, half century after the original creed was written, we find ourselves in a world with great technological advances and great global-scale technologically-enabled peril. These issues can be naturally integrated into the engineering curriculum in a way that enhances the development of the technological skill set. We have found that these global challenges create a natural opportunity to foster social responsibility within the engineering students whom we educate. In freshman through senior-level materials engineering courses, we used five guiding principles to shape several different classroom activities and assignments. Upon testing an initial cohort of 28 students had classroom experiences based on these five principles, we saw a shift in attitude: before the experience, 18% of the cohort viewed engineers as playing an active role in solving global problems; after the experiences, 79% recognized the engineer's role in solving global-scale problems. In this paper, we present how global issues can be used to stimulate thinking for socially-responsible engineering solutions. We set forth five guiding principles that can foster the mindset for socially responsible actions along with examples of how these principles translate into classroom activities.

The importance of meta-ethics in engineering education.

PubMed

Haws, David R

2004-04-01

Our shared moral framework is negotiated as part of the social contract. Some elements of that framework are established (tell the truth under oath), but other elements lack an overlapping consensus (just when can an individual lie to protect his or her privacy?). The tidy bits of our accepted moral framework have been codified, becoming the subject of legal rather than ethical consideration. Those elements remaining in the realm of ethics seem fragmented and inconsistent. Yet, our engineering students will need to navigate the broken ground of this complex moral landscape. A minimalist approach would leave our students with formulated dogma--principles of right and wrong such as the National Society for Professional Engineers (NSPE) Code of Ethics for Engineers--but without any insight into the genesis of these principles. A slightly deeper, micro-ethics approach would teach our students to solve ethical problems by applying heuristics--giving our students a rational process to manipulate ethical dilemmas using the same principles simply referenced a priori by dogma. A macro-ethics approach--helping students to inductively construct a posteriori principles from case studies--goes beyond the simple statement or manipulation of principles, but falls short of linking personal moral principles to the larger, social context. Ultimately, it is this social context that requires both the application of ethical principles, and the negotiation of moral values--from an understanding of meta-ethics. The approaches to engineering ethics instruction (dogma, heuristics, case studies, and meta-ethics) can be associated with stages of moral development. If we leave our students with only a dogmatic reaction to ethical dilemmas, they will be dependent on the ethical decisions of others (a denial of their fundamental potential for moral autonomy). Heuristics offers a tool to deal independently with moral questions, but a tool that too frequently reduces to casuistry when rigidly applied to "simplified" dilemmas. Case studies, while providing a context for engineering ethics, can encourage the premature analysis of specific moral conduct rather than the development of broad moral principles--stifling our students' facility with meta-ethics. Clearly, if a moral sense is developmental, ethics instruction should lead our students from lower to higher stages of moral development.

Technology transfer in software engineering

NASA Technical Reports Server (NTRS)

Bishop, Peter C.

1989-01-01

The University of Houston-Clear Lake is the prime contractor for the AdaNET Research Project under the direction of NASA Johnson Space Center. AdaNET was established to promote the principles of software engineering to the software development industry. AdaNET will contain not only environments and tools, but also concepts, principles, models, standards, guidelines and practices. Initially, AdaNET will serve clients from the U.S. government and private industry who are working in software development. It will seek new clients from those who have not yet adopted the principles and practices of software engineering. Some of the goals of AdaNET are to become known as an objective, authoritative source of new software engineering information and parts, to provide easy access to information and parts, and to keep abreast of innovations in the field.

Lessons Learned in Engineering. Supplement

NASA Technical Reports Server (NTRS)

Blair, James C.; Ryan, Robert S.; Schultzenhofer, Luke A.

2011-01-01

This Contractor Report (CR) is a compilation of Lessons Learned in approximately 55 years of engineering experience by each James C. Blair, Robert S. Ryan, and Luke A. Schutzenhofer. The lessons are the basis of a course on Lessons Learned that has been taught at Marshall Space Flight Center. The lessons are drawn from NASA space projects and are characterized in terms of generic lessons learned from the project experience, which are further distilled into overarching principles that can be applied to future projects. Included are discussions of the overarching principles followed by a listing of the lessons associated with that principle. The lesson with sub-lessons are stated along with a listing of the project problems the lesson is drawn from, then each problem is illustrated and discussed, with conclusions drawn in terms of Lessons Learned. The purpose of this CR is to provide principles learned from past aerospace experience to help achieve greater success in future programs, and identify application of these principles to space systems design. The problems experienced provide insight into the engineering process and are examples of the subtleties one experiences performing engineering design, manufacturing, and operations. The supplemental CD contains accompanying PowerPoint presentations.

Integrated Turbine Tip Clearance and Gas Turbine Engine Simulation

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Kratz, Jonathan; Guo, Ten-Huei; Litt, Jonathan

2016-01-01

Gas turbine compressor and turbine blade tip clearance (i.e., the radial distance between the blade tip of an axial compressor or turbine and the containment structure) is a major contributing factor to gas path sealing, and can significantly affect engine efficiency and operational temperature. This paper details the creation of a generic but realistic high pressure turbine tip clearance model that may be used to facilitate active tip clearance control system research. This model uses a first principles approach to approximate thermal and mechanical deformations of the turbine system, taking into account the rotor, shroud, and blade tip components. Validation of the tip clearance model shows that the results are realistic and reflect values found in literature. In addition, this model has been integrated with a gas turbine engine simulation, creating a platform to explore engine performance as tip clearance is adjusted. Results from the integrated model explore the effects of tip clearance on engine operation and highlight advantages of tip clearance management.

Engineering Encounters: Teaching Educators about Engineering

ERIC Educational Resources Information Center

Tank, Kristina M.; Raman, D. Raj; Lamm, Monica H.; Sundararajan, Sriram; Estapa, Anne

2017-01-01

This column presents ideas and techniques to enhance science teaching. This month's issue describes preservice elementary teachers learning engineering principles from engineers. Few elementary teachers have experience with implementing engineering into the classroom. While engineering professional development opportunities for inservice teachers…

Software Engineering Principles for Courseware Development.

ERIC Educational Resources Information Center

Magel, Kenneth

1980-01-01

Courseware (computer based curriculum materials) development should follow the lessons learned by software engineers. The most important of 28 principles of software development presented here include a stress on human readability, the importance of early planning and analysis, the need for independent evaluation, and the need to be flexible.…

Fundamentals of Diesel Engines.

ERIC Educational Resources Information Center

Marine Corps Inst., Washington, DC.

This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the fundamentals of diesel engine mechanics. Addressed in the three individual units of the course are the following topics: basic principles of diesel mechanics; principles, mechanics, and…

Effects of an Advanced Reactor’s Design, Use of Automation, and Mission on Human Operators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffrey C. Joe; Johanna H. Oxstrand

The roles, functions, and tasks of the human operator in existing light water nuclear power plants (NPPs) are based on sound nuclear and human factors engineering (HFE) principles, are well defined by the plant’s conduct of operations, and have been validated by years of operating experience. However, advanced NPPs whose engineering designs differ from existing light-water reactors (LWRs) will impose changes on the roles, functions, and tasks of the human operators. The plans to increase the use of automation, reduce staffing levels, and add to the mission of these advanced NPPs will also affect the operator’s roles, functions, and tasks.more » We assert that these factors, which do not appear to have received a lot of attention by the design engineers of advanced NPPs relative to the attention given to conceptual design of these reactors, can have significant risk implications for the operators and overall plant safety if not mitigated appropriately. This paper presents a high-level analysis of a specific advanced NPP and how its engineered design, its plan to use greater levels of automation, and its expanded mission have risk significant implications on operator performance and overall plant safety.« less

How can systems engineering inform the methods of programme evaluation in health professions education?

PubMed

Rojas, David; Grierson, Lawrence; Mylopoulos, Maria; Trbovich, Patricia; Bagli, Darius; Brydges, Ryan

2018-04-01

We evaluate programmes in health professions education (HPE) to determine their effectiveness and value. Programme evaluation has evolved from use of reductionist frameworks to those addressing the complex interactions between programme factors. Researchers in HPE have recently suggested a 'holistic programme evaluation' aiming to better describe and understand the implications of 'emergent processes and outcomes'. We propose a programme evaluation framework informed by principles and tools from systems engineering. Systems engineers conceptualise complexity and emergent elements in unique ways that may complement and extend contemporary programme evaluations in HPE. We demonstrate how the abstract decomposition space (ADS), an engineering knowledge elicitation tool, provides the foundation for a systems engineering informed programme evaluation designed to capture both planned and emergent programme elements. We translate the ADS tool to use education-oriented language, and describe how evaluators can use it to create a programme-specific ADS through iterative refinement. We provide a conceptualisation of emergent elements and an equation that evaluators can use to identify the emergent elements in their programme. Using our framework, evaluators can analyse programmes not as isolated units with planned processes and planned outcomes, but as unfolding, complex interactive systems that will exhibit emergent processes and emergent outcomes. Subsequent analysis of these emergent elements will inform the evaluator as they seek to optimise and improve the programme. Our proposed systems engineering informed programme evaluation framework provides principles and tools for analysing the implications of planned and emergent elements, as well as their potential interactions. We acknowledge that our framework is preliminary and will require application and constant refinement. We suggest that our framework will also advance our understanding of the construct of 'emergence' in HPE research. © 2017 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

A computer model for liquid jet atomization in rocket thrust chambers

NASA Astrophysics Data System (ADS)

Giridharan, M. G.; Lee, J. G.; Krishnan, A.; Yang, H. Q.; Ibrahim, E.; Chuech, S.; Przekwas, A. J.

1991-12-01

The process of atomization has been used as an efficient means of burning liquid fuels in rocket engines, gas turbine engines, internal combustion engines, and industrial furnaces. Despite its widespread application, this complex hydrodynamic phenomenon has not been well understood, and predictive models for this process are still in their infancy. The difficulty in simulating the atomization process arises from the relatively large number of parameters that influence it, including the details of the injector geometry, liquid and gas turbulence, and the operating conditions. In this study, numerical models are developed from first principles, to quantify factors influencing atomization. For example, the surface wave dynamics theory is used for modeling the primary atomization and the droplet energy conservation principle is applied for modeling the secondary atomization. The use of empirical correlations has been minimized by shifting the analyses to fundamental levels. During applications of these models, parametric studies are performed to understand and correlate the influence of relevant parameters on the atomization process. The predictions of these models are compared with existing experimental data. The main tasks of this study were the following: development of a primary atomization model; development of a secondary atomization model; development of a model for impinging jets; development of a model for swirling jets; and coupling of the primary atomization model with a CFD code.

Research approach to teaching groundwater biodegradation in karst aquifers

USGS Publications Warehouse

King, L.; Byl, T.; Painter, R.

2006-01-01

TSU in partnership with the USGS has conducted extensive research regarding biode??gradation of contaminants in karst aquifers. This research resulted in the development of a numerical approach to modeling biodegradation of contaminants in karst aquifers that is taught to environmental engineering students in several steps. First, environmental engineering students are taught chemical-reaction engineering principles relating to a wide variety of environmental fate and transport issues. Second, as part of TSU's engineering course curriculum, students use a non-ideal flow laboratory reactor system and run a tracer study to establish residence time distribution (RTD). Next, the students couple that formula to a first-order biodegradation rate and predict the removal of a biodegradable contaminant as a function of residence time. Following this, students are shown data collected from karst bedrock wells that suggest that karst aquifers are analogous to non-ideal flow reactors. The students are challenged to develop rates of biodegradation through lab studies and use their results to predict biodegradaton at an actual contaminated karst site. Field studies are also conducted to determine the accuracy of the students' predictions. This academic approach teaches biodegradation processes, rate-kinetic processes, hydraulic processes and numerical principles. The students are able to experience how chemical engineering principles can be applied to other situations, such as, modeling biodegradation of contaminants in karst aquifers. This paper provides background on the chemical engineering principles and karst issues used in the research-enhanced curriculum. ?? American Society for Engineering Education, 2006.

Practical Application of Sociology in Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Andrews, James G.; Eckley, Jeri Cassel; Culver, Michael L.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, who often have different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated will all relevant information informing system decisions. The practical application of the sociology in systems engineering brings in various organizational development concepts including the principles of planned renegotiation and the application of principles to address information barriers created by organizational culture. Concepts such as specification of ignorance, consistent terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that help address the organizational social structure (culture). In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, and insider-outsider behavior. Unintended consequences can result when these social issues are present. These issues can occur when localized subcultures shift from the overarching organizational culture, or when the organizational culture prevents achievement of system goals. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information and provides key sociological barriers to information flow through the organization. This paper will discuss the practical application of sociological principles to systems engineering.

The Effectiveness of Contextual Learning on Physics Achievement in Career Technical Education

NASA Astrophysics Data System (ADS)

Arcand, Scott Andrew

The purpose of this casual-comparative study was to determine if students being taught the Minnesota Science Physics Standards via contextual learning methods in Project Lead the Way (PLTW) Principles of Engineering or the PLTW Aerospace Engineering courses, taught by a Career Technical Education (CTE) teacher, achieve at the same rate as students in a physics course taught by a science teacher. The PLTW courses only cover the standards taught in the first trimester of physics. The PLTW courses are two periods long for one trimester. Students who successfully pass the PLTW Principles of Engineering course or the PLTW Engineering Aerospace course earn one-half credit in physics and one-half elective credit. The instrument used to measure student achievement was the district common summative assessment for physics. The Common Summative Assessment scores were pulled from the data warehouse from the first trimester of the 2013-2014 school year. Implications of the research address concepts of contextual learning especially in the Career Technical Education space. The mean score for Physics students (30.916) and PLTW Principles of Engineering students (32.333) was not statistically significantly different. Students in PLTW Principles of Engineering achieved at the same rate as students in physics. Due to the low rate of students participating in the Common Summative Assessment in PTLW Aerospace (four out of seven students), there is not enough data to determine if there is a significant difference in the Physics A scores and PLTW Aerospace Engineering scores.

Engineering Robustness of Microbial Cell Factories.

PubMed

Gong, Zhiwei; Nielsen, Jens; Zhou, Yongjin J

2017-10-01

Metabolic engineering and synthetic biology offer great prospects in developing microbial cell factories capable of converting renewable feedstocks into fuels, chemicals, food ingredients, and pharmaceuticals. However, prohibitively low production rate and mass concentration remain the major hurdles in industrial processes even though the biosynthetic pathways are comprehensively optimized. These limitations are caused by a variety of factors unamenable for host cell survival, such as harsh industrial conditions, fermentation inhibitors from biomass hydrolysates, and toxic compounds including metabolic intermediates and valuable target products. Therefore, engineered microbes with robust phenotypes is essential for achieving higher yield and productivity. In this review, the recent advances in engineering robustness and tolerance of cell factories is described to cope with these issues and briefly introduce novel strategies with great potential to enhance the robustness of cell factories, including metabolic pathway balancing, transporter engineering, and adaptive laboratory evolution. This review also highlights the integration of advanced systems and synthetic biology principles toward engineering the harmony of overall cell function, more than the specific pathways or enzymes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

PubMed Central

Rodriguez, Isaac A.; Growney Kalaf, Emily A.; Bowlin, Gary L.; Sell, Scott A.

2014-01-01

Human bone is a tissue with a fairly remarkable inherent capacity for regeneration; however, this regenerative capacity has its limitations, and defects larger than a critical size lack the ability to spontaneously heal. As such, the development and clinical translation of effective bone regeneration modalities are paramount. One regenerative medicine approach that is beginning to gain momentum in the clinical setting is the use of platelet-rich plasma (PRP). PRP therapy is essentially a method for concentrating platelets and their intrinsic growth factors to stimulate and accelerate a healing response. While PRP has shown some efficacy in both in vitro and in vivo scenarios, to date its use and delivery have not been optimized for bone regeneration. Issues remain with the effective delivery of the platelet-derived growth factors to a localized site of injury, the activation and temporal release of the growth factors, and the rate of growth factor clearance. This review will briefly describe the physiological principles behind PRP use and then discuss how engineering its method of delivery may ultimately impact its ability to successfully translate to widespread clinical use. PMID:25050347

Application of the Total Quality Management Approach Principles and the ISO 9000 Standards in Engineering Education.

ERIC Educational Resources Information Center

Waks, Shlomo; Frank, Moti

1999-01-01

Discusses the applicability of the definition, principles, and underlying strategies of total quality management (TQM) for engineering education. Describes several tools and methods for the implementation of TQM and its suitability for a variety of school activities. Presents a TQM course outline combining lectures, discussions, suggested…

Integrating Sustainable Development in Chemical Engineering Education: The Application of an Environmental Management System

ERIC Educational Resources Information Center

Montanes, M. T.; Palomares, A. E.; Sanchez-Tovar, R.

2012-01-01

The principles of sustainable development have been integrated in chemical engineering education by means of an environmental management system. These principles have been introduced in the teaching laboratories where students perform their practical classes. In this paper, the implementation of the environmental management system, the problems…

An Undergraduate Course on Operating Systems Principles.

ERIC Educational Resources Information Center

National Academy of Engineering, Washington, DC. Commission on Education.

This report is from Task Force VIII of the COSINE Committee of the Commission on Education of the National Academy of Engineering. The task force was established to formulate subject matter for an elective undergraduate subject on computer operating systems principles for students whose major interest is in the engineering of computer systems and…

Using engineering control principles to inform the design of adaptive interventions: a conceptual introduction.

PubMed

Rivera, Daniel E; Pew, Michael D; Collins, Linda M

2007-05-01

The goal of this paper is to describe the role that control engineering principles can play in developing and improving the efficacy of adaptive, time-varying interventions. It is demonstrated that adaptive interventions constitute a form of feedback control system in the context of behavioral health. Consequently, drawing from ideas in control engineering has the potential to significantly inform the analysis, design, and implementation of adaptive interventions, leading to improved adherence, better management of limited resources, a reduction of negative effects, and overall more effective interventions. This article illustrates how to express an adaptive intervention in control engineering terms, and how to use this framework in a computer simulation to investigate the anticipated impact of intervention design choices on efficacy. The potential benefits of operationalizing decision rules based on control engineering principles are particularly significant for adaptive interventions that involve multiple components or address co-morbidities, situations that pose significant challenges to conventional clinical practice.

Using Engineering Control Principles to Inform the Design of Adaptive Interventions: A Conceptual Introduction

PubMed Central

Rivera, Daniel E.; Pew, Michael D.; Collins, Linda M.

2007-01-01

The goal of this paper is to describe the role that control engineering principles can play in developing and improving the efficacy of adaptive, time-varying interventions. It is demonstrated that adaptive interventions constitute a form of feedback control system in the context of behavioral health. Consequently, drawing from ideas in control engineering has the potential to significantly inform the analysis, design, and implementation of adaptive interventions, leading to improved adherence, better management of limited resources, a reduction of negative effects, and overall more effective interventions. This article illustrates how to express an adaptive intervention in control engineering terms, and how to use this framework in a computer simulation to investigate the anticipated impact of intervention design choices on efficacy. The potential benefits of operationalizing decision rules based on control engineering principles are particularly significant for adaptive interventions that involve multiple components or address co-morbidities, situations that pose significant challenges to conventional clinical practice. PMID:17169503

Basic Study on Engine with Scroll Compressor and Expander

NASA Astrophysics Data System (ADS)

Morishita, Etsuo; Kitora, Yoshihisa; Nishida, Mitsuhiro

Scroll compressors are becoming popular in air conditioning and refrigeration. This is primarily due to their higher efficiency and low noise/vibration characteristics. The scroll principle can be applied also to the steam expander and the Brayton cycle engine,as shown in the past literature. The Otto cycle spark-ignition engine with a scroll compressor and expander is studied in this report. The principle and basic structure of the scroll engine are explained,and the engine characteristic are calculated based on the idealized cycles and processes. A prototype model has been proposed and constructed. The rotary type engine has always had a problem with sealing. The scroll engine might overcome this shortcoming with its much lower rubbing speed compared to its previous counterparts,and is therefore worth investigating.

The Faster, Better, Cheaper Approach to Space Missions: An Engineering Management Assessment

NASA Technical Reports Server (NTRS)

Hamaker, Joe

2000-01-01

This paper describes, in viewgraph form, the faster, better, cheaper approach to space missions. The topics include: 1) What drives "Faster, Better, Cheaper"? 2) Why Space Programs are Costly; 3) Background; 4) Aerospace Project Management (Old Culture); 5) Aerospace Project Management (New Culture); 6) Scope of Analysis Limited to Engineering Management Culture; 7) Qualitative Analysis; 8) Some Basic Principles of the New Culture; 9) Cause and Effect; 10) "New Ways of Doing Business" Survey Results; 11) Quantitative Analysis; 12) Recent Space System Cost Trends; 13) Spacecraft Dry Weight Trend; 14) Complexity Factor Trends; 15) Cost Normalization; 16) Cost Normalization Algorithm; 17) Unnormalized Cost vs. Normalized Cost; and 18) Concluding Observations.

The Application of the Human Engineering Modeling and Performance Laboratory for Space Vehicle Ground Processing Tasks at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Woodbury, Sarah K.

2008-01-01

The introduction of United Space Alliance's Human Engineering Modeling and Performance Laboratory began in early 2007 in an attempt to address the problematic workspace design issues that the Space Shuttle has imposed on technicians performing maintenance and inspection operations. The Space Shuttle was not expected to require the extensive maintenance it undergoes between flights. As a result, extensive, costly resources have been expended on workarounds and modifications to accommodate ground processing personnel. Consideration of basic human factors principles for design of maintenance is essential during the design phase of future space vehicles, facilities, and equipment. Simulation will be needed to test and validate designs before implementation.

Simulation technology - A key to effective man-machine integration for future combat rotorcraft systems

NASA Technical Reports Server (NTRS)

Kerr, Andrew W.

1990-01-01

The utilization of advanced simulation technology in the development of the non-real-time MANPRINT design tools in the Army/NASA Aircrew-Aircraft Integration (A3I) program is described. A description is then given of the Crew Station Research and Development Facilities, the primary tool for the application of MANPRINT principles. The purpose of the A3I program is to develop a rational, predictive methodology for helicopter cockpit system design that integrates human factors engineering with other principles at an early stage in the development process, avoiding the high cost of previous system design methods. Enabling technologies such as the MIDAS work station are examined, and the potential of low-cost parallel-processing systems is indicated.

The morality of socioscientific issues: Construal and resolution of genetic engineering dilemmas

NASA Astrophysics Data System (ADS)

Sadler, Troy D.; Zeidler, Dana L.

2004-01-01

The ability to negotiate and resolve socioscientific issues has been posited as integral components of scientific literacy. Although philosophers and science educators have argued that socioscientific issues inherently involve moral and ethical considerations, the ultimate arbiters of morality are individual decision-makers. This study explored the extent to which college students construe genetic engineering issues as moral problems. Twenty college students participated in interviews designed to elicit their ideas, reactions, and feelings regarding a series of gene therapy and cloning scenarios. Qualitative analyses revealed that moral considerations were significant influences on decision-making, indicating a tendency for students to construe genetic engineering issues as moral problems. Students engaged in moral reasoning based on utilitarian analyses of consequences as well as the application of principles. Issue construal was also influenced by affective features such as emotion and intuition. In addition to moral considerations, a series of other factors emerged as important dimensions of socioscientific decision-making. These factors included personal experiences, family biases, background knowledge, and the impact of popular culture. The implications for classroom science instruction and future research are discussed.

The Pursuit of Chronically Reliable Neural Interfaces: A Materials Perspective.

PubMed

Guo, Liang

2016-01-01

Brain-computer interfaces represent one of the most astonishing technologies in our era. However, the grand challenge of chronic instability and limited throughput of the electrode-tissue interface has significantly hindered the further development and ultimate deployment of such exciting technologies. A multidisciplinary research workforce has been called upon to respond to this engineering need. In this paper, I briefly review this multidisciplinary pursuit of chronically reliable neural interfaces from a materials perspective by analyzing the problem, abstracting the engineering principles, and summarizing the corresponding engineering strategies. I further draw my future perspectives by extending the proposed engineering principles.

The shear-lag effect of thin-walled box girder under vertical earthquake excitation

NASA Astrophysics Data System (ADS)

Zhai, Zhipeng; Li, Yaozhuang; Guo, Wei

2017-03-01

The variation method based on the energy variation principle is proved to be accurate and valid for analyzing the shear lag effect of box girder under static and dynamic load. Meanwhile, dynamic problems gradually become the key factors in engineering practice. Therefore, a method for calculating the shear lag effect in thin-walled box girder under vertical seismic excitation is proposed by applying Hamilton Principle in this paper. The Timoshenko shear deformation is taken into account. And a new definition of shear lag ratio for box girder is given. What's more, some conclusions are drawn by analysis of numerical example. The results show that small amplitude of earthquake ground motion can generate high stress and obvious shear lag, especially in the region of resonance. And the influence of rotary inertia cannot be ignored for analyzing the shear lag effect. With the increase of span to width ratio, shear lag effect becomes smaller and smaller. These research conclusions will be useful for the engineering practice and enrich the theoretical studies of box girders.

Principles of Biomimetic Vascular Network Design Applied to a Tissue-Engineered Liver Scaffold

PubMed Central

Hoganson, David M.; Pryor, Howard I.; Spool, Ira D.; Burns, Owen H.; Gilmore, J. Randall

2010-01-01

Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow. PMID:20001254

Principles of biomimetic vascular network design applied to a tissue-engineered liver scaffold.

PubMed

Hoganson, David M; Pryor, Howard I; Spool, Ira D; Burns, Owen H; Gilmore, J Randall; Vacanti, Joseph P

2010-05-01

Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow.

The Underrepresentation of Women in the Engineering Element of STEM Occupations and Influencers Contributing to the Persistent Gap

NASA Astrophysics Data System (ADS)

Holl, David

Within Science, Technology, Engineering, and Mathematics (STEM) careers fields, the representation of women remains at an inequitable level when compared to men and to women's representation in other professions. Given the current state of women representing 52% of the professional and management-related workforce (U.S. Bureau of Labor and Statistics, 2015), their representation at only 15% of employed engineers nationwide appears to be a problem. When considering the fact that recent graduation data show women earn over 19% of Bachelor's degrees in engineering each year, the low number becomes increasingly puzzling. What factors are contributing to this low number of women in engineering professions? One of the contributing factors is clearly women's choice of education and career paths. However, empirical literature suggests, after pursuing and entering the engineer profession, women often are victim to gender schema, cognitive bias, and an absence of family-friendly work policies, an insufficient number of female mentors, social exclusion, and other drivers potentially leading to their higher turnover rate compared to their male counterparts. This project looks within one military-related organization to uncover reasons for the low representation of female engineers. The combination of a mixed-methods approach to data collection and the Knowledge, Motivation, and Organization (KMO) framework developed by Clark and Estes (2008) for analysis is employed by this project. Comparison of the analysis results to widely accepted learning and motivation principles presented in the reviewed literature led to a proposal of research-based solutions to address the representation gap and ultimately increase women's representation in engineering and other STEM career fields.

Designing a 'neotissue' using the principles of biology, chemistry and engineering.

PubMed

Nannaparaju, Madhusudhan; Oragui, Emeka; Khan, Wasim S

2012-01-01

The traditional methods of treating musculoskeletal injuries and disorders are not completely effective and have several limitations. Tissue engineering involves using the principles of biology, chemistry and engineering to design a 'neotissue' that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. In this review we provide an overview of the biology of common musculoskeletal tissue and discuss their common pathologies. We also describe the commonly used stem cells, scaffolds and bioreactors and evaluate their role in issue engineering.

Basic Principles of Marine Diesel Engines, 8-2. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This volume of student materials for a secondary/postsecondary level course in principles of marine diesel engines is one of a number of military-developed curriculum packages selected for adaptation to vocational instruction and curriculum development in a civilian setting. The purpose of the individualized, self-paced course is to acquaint…

Construction Mechanic Part I, 8-5. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This course, adapted from military curriculum materials for use in vocational and technical education, is the first of a two-course series that teaches students to maintain and repair automotive and construction equipment using either gasoline or diesel engines. It covers basic combustion engine principles and electrical system principles as well…

The technology improvement and development of the new design-engineering principles of pilot bore directional drilling

NASA Astrophysics Data System (ADS)

Shadrina, A.; Saruev, L.; Vasenin, S.

2016-09-01

This paper addresses the effectiveness of impact energy use in pilot bore directional drilling at pipe driving. We establish and develop new design-engineering principles for this method. These principles are based on a drill string construction with a new nipple thread connection and a generator construction of strain waves transferred through the drill string. The experiment was conducted on a test bench. Strain measurement is used to estimate compression, tensile, shear and bending stresses in the drill string during the propagation of elastic waves. Finally, the main directions of pilot bore directional drilling improvement during pipe driving are determinated. The new engineering design, as components of the pilot bore directional drilling technology are presented.

Assessment of Human Factors

NASA Technical Reports Server (NTRS)

Mount, Frances; Foley, Tico

1999-01-01

Human Factors Engineering, often referred to as Ergonomics, is a science that applies a detailed understanding of human characteristics, capabilities, and limitations to the design, evaluation, and operation of environments, tools, and systems for work and daily living. Human Factors is the investigation, design, and evaluation of equipment, techniques, procedures, facilities, and human interfaces, and encompasses all aspects of human activity from manual labor to mental processing and leisure time enjoyments. In spaceflight applications, human factors engineering seeks to: (1) ensure that a task can be accomplished, (2) maintain productivity during spaceflight, and (3) ensure the habitability of the pressurized living areas. DSO 904 served as a vehicle for the verification and elucidation of human factors principles and tools in the microgravity environment. Over six flights, twelve topics were investigated. This study documented the strengths and limitations of human operators in a complex, multifaceted, and unique environment. By focusing on the man-machine interface in space flight activities, it was determined which designs allow astronauts to be optimally productive during valuable and costly space flights. Among the most promising areas of inquiry were procedures, tools, habitat, environmental conditions, tasking, work load, flexibility, and individual control over work.

Evolutionary engineering for industrial microbiology.

PubMed

Vanee, Niti; Fisher, Adam B; Fong, Stephen S

2012-01-01

Superficially, evolutionary engineering is a paradoxical field that balances competing interests. In natural settings, evolution iteratively selects and enriches subpopulations that are best adapted to a particular ecological niche using random processes such as genetic mutation. In engineering desired approaches utilize rational prospective design to address targeted problems. When considering details of evolutionary and engineering processes, more commonality can be found. Engineering relies on detailed knowledge of the problem parameters and design properties in order to predict design outcomes that would be an optimized solution. When detailed knowledge of a system is lacking, engineers often employ algorithmic search strategies to identify empirical solutions. Evolution epitomizes this iterative optimization by continuously diversifying design options from a parental design, and then selecting the progeny designs that represent satisfactory solutions. In this chapter, the technique of applying the natural principles of evolution to engineer microbes for industrial applications is discussed to highlight the challenges and principles of evolutionary engineering.

Suggested criteria for evaluating systems engineering methodologies

NASA Technical Reports Server (NTRS)

Gates, Audrey; Paul, Arthur S.; Gill, Tepper L.

1989-01-01

Systems engineering is the application of mathematical and scientific principles to practical ends in the life-cycle of a system. A methodology for systems engineering is a carefully developed, relatively complex procedure or process for applying these mathematical and scientific principles. There are many systems engineering methodologies (or possibly many versions of a few methodologies) currently in use in government and industry. These methodologies are usually designed to meet the needs of a particular organization. It has been observed, however, that many technical and non-technical problems arise when inadequate systems engineering methodologies are applied by organizations to their systems development projects. Various criteria for evaluating systems engineering methodologies are discussed. Such criteria are developed to assist methodology-users in identifying and selecting methodologies that best fit the needs of the organization.

Diesel Technology: Engines. [Teacher and Student Editions.

ERIC Educational Resources Information Center

Barbieri, Dave; Miller, Roger; Kellum, Mary

Competency-based teacher and student materials on diesel engines are provided for a diesel technology curriculum. Seventeen units of instruction cover the following topics: introduction to engine principles and procedures; engine systems and components; fuel systems; engine diagnosis and maintenance. The materials are based on the…

Heat Transfer Principles in Thermal Calculation of Structures in Fire

PubMed Central

Zhang, Chao; Usmani, Asif

2016-01-01

Structural fire engineering (SFE) is a relatively new interdisciplinary subject, which requires a comprehensive knowledge of heat transfer, fire dynamics and structural analysis. It is predominantly the community of structural engineers who currently carry out most of the structural fire engineering research and design work. The structural engineering curriculum in universities and colleges do not usually include courses in heat transfer and fire dynamics. In some institutions of higher education, there are graduate courses for fire resistant design which focus on the design approaches in codes. As a result, structural engineers who are responsible for structural fire safety and are competent to do their jobs by following the rules specified in prescriptive codes may find it difficult to move toward performance-based fire safety design which requires a deep understanding of both fire and heat. Fire safety engineers, on the other hand, are usually focused on fire development and smoke control, and may not be familiar with the heat transfer principles used in structural fire analysis, or structural failure analysis. This paper discusses the fundamental heat transfer principles in thermal calculation of structures in fire, which might serve as an educational guide for students, engineers and researchers. Insights on problems which are commonly ignored in performance based fire safety design are also presented. PMID:26783379

Rapid prototyping technology and its application in bone tissue engineering*

PubMed Central

YUAN, Bo; ZHOU, Sheng-yuan; CHEN, Xiong-sheng

2017-01-01

Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects. PMID:28378568

Rapid prototyping technology and its application in bone tissue engineering.

PubMed

Yuan, Bo; Zhou, Sheng-Yuan; Chen, Xiong-Sheng

Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.

The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine

PubMed Central

Butler, David L.; Goldstein, Steven A.; Guo, X. Edward; Kamm, Roger; Laurencin, Cato T.; McIntire, Larry V.; Mow, Van C.; Nerem, Robert M.; Sah, Robert L.; Soslowsky, Louis J.; Spilker, Robert L.; Tranquillo, Robert T.

2009-01-01

Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges. PMID:19583462

Current and future regenerative medicine — Principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine

PubMed Central

Koch, Thomas G.; Berg, Lise C.; Betts, Dean H.

2009-01-01

This paper provides a bird’s-eye perspective of the general principles of stem-cell therapy and tissue engineering; it relates comparative knowledge in this area to the current and future status of equine regenerative medicine. The understanding of equine stem cell biology, biofactors, and scaffolds, and their potential therapeutic use in horses are rudimentary at present. Mesenchymal stem cell isolation has been proclaimed from several equine tissues in the past few years. Based on the criteria of the International Society for Cellular Therapy, most of these cells are more correctly referred to as multipotent mesenchymal stromal cells, unless there is proof that they exhibit the fundamental in vivo characteristics of pluripotency and the ability to self-renew. That said, these cells from various tissues hold great promise for therapeutic use in horses. The 3 components of tissue engineering — cells, biological factors, and biomaterials — are increasingly being applied in equine medicine, fuelled by better scaffolds and increased understanding of individual biofactors and cell sources. The effectiveness of stem cell-based therapies and most tissue engineering concepts has not been demonstrated sufficiently in controlled clinical trials in equine patients to be regarded as evidence-based medicine. In the meantime, the medical mantra “do no harm” should prevail, and the application of stem cell-based therapies in the horse should be done critically and cautiously, and treatment outcomes (good and bad) should be recorded and reported. Stem cell and tissue engineering research in the horse has exciting comparative and equine specific perspectives that most likely will benefit the health of horses and humans. Controlled, well-designed studies are needed to move this new equine research field forward. PMID:19412395

Standardized Curriculum for Diesel Engine Mechanics.

ERIC Educational Resources Information Center

Mississippi State Dept. of Education, Jackson. Office of Vocational, Technical and Adult Education.

Standardized curricula are provided for two courses for the secondary vocational education program in Mississippi: diesel engine mechanics I and II. The eight units in diesel engine mechanics I are as follows: orientation; shop safety; basic shop tools; fasteners; measurement; engine operating principles; engine components; and basic auxiliary…

Fundamentals of fluid lubrication

NASA Technical Reports Server (NTRS)

Hamrock, Bernard J.

1991-01-01

The aim is to coordinate the topics of design, engineering dynamics, and fluid dynamics in order to aid researchers in the area of fluid film lubrication. The lubrication principles that are covered can serve as a basis for the engineering design of machine elements. The fundamentals of fluid film lubrication are presented clearly so that students that use the book will have confidence in their ability to apply these principles to a wide range of lubrication situations. Some guidance on applying these fundamentals to the solution of engineering problems is also provided.

Forensic engineering: applying materials and mechanics principles to the investigation of product failures.

PubMed

Hainsworth, S V; Fitzpatrick, M E

2007-06-01

Forensic engineering is the application of engineering principles or techniques to the investigation of materials, products, structures or components that fail or do not perform as intended. In particular, forensic engineering can involve providing solutions to forensic problems by the application of engineering science. A criminal aspect may be involved in the investigation but often the problems are related to negligence, breach of contract, or providing information needed in the redesign of a product to eliminate future failures. Forensic engineering may include the investigation of the physical causes of accidents or other sources of claims and litigation (for example, patent disputes). It involves the preparation of technical engineering reports, and may require giving testimony and providing advice to assist in the resolution of disputes affecting life or property.This paper reviews the principal methods available for the analysis of failed components and then gives examples of different component failure modes through selected case studies.

Basic principles for rational design of high-performance nanostructured silicon-based thermoelectric materials.

PubMed

Yang, Chun Cheng; Li, Sean

2011-12-23

Recently, nanostructured silicon-based thermoelectric materials have drawn great attention owing to their excellent thermoelectric performance in the temperature range around 450 °C, which is eminently applicable for concentrated solar thermal technology. In this work, a unified nanothermodynamic model is developed to investigate the predominant factors that determine the lattice thermal conductivity of nanocrystalline, nanoporous, and nanostructured bulk Si. A systematic study shows that the thermoelectric performance of these materials can be substantially enhanced by the following three basic principles: 1) artificial manipulation and optimization of roughness with surface/interface patterning/engineering; 2) grain-size reduction with innovative fabrication techniques in a controllable fashion; and 3) optimization of material parameters, such as bulk solid-vapor transition entropy, bulk vibrational entropy, dimensionality, and porosity, to decrease the lattice thermal conductivity. These principles may be used to rationally design novel nanostructured Si-based thermoelectric materials for renewable energy applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Principles of thermoacoustic energy harvesting

NASA Astrophysics Data System (ADS)

Avent, A. W.; Bowen, C. R.

2015-11-01

Thermoacoustics exploit a temperature gradient to produce powerful acoustic pressure waves. The technology has a key role to play in energy harvesting systems. A time-line in the development of thermoacoustics is presented from its earliest recorded example in glass blowing through to the development of the Sondhauss and Rijke tubes to Stirling engines and pulse-tube cryo-cooling. The review sets the current literature in context, identifies key publications and promising areas of research. The fundamental principles of thermoacoustic phenomena are explained; design challenges and factors influencing efficiency are explored. Thermoacoustic processes involve complex multi-physical coupling and transient, highly non-linear relationships which are computationally expensive to model; appropriate numerical modelling techniques and options for analyses are presented. Potential methods of harvesting the energy in the acoustic waves are also examined.

Process quality engineering for bioreactor-driven manufacturing of tissue-engineered constructs for bone regeneration.

PubMed

Papantoniou Ir, Ioannis; Chai, Yoke Chin; Luyten, Frank P; Schrooten Ir, Jan

2013-08-01

The incorporation of Quality-by-Design (QbD) principles in tissue-engineering bioprocess development toward clinical use will ensure that manufactured constructs possess prerequisite quality characteristics addressing emerging regulatory requirements and ensuring the functional in vivo behavior. In this work, the QbD principles were applied on a manufacturing process step for the in vitro production of osteogenic three-dimensional (3D) hybrid scaffolds that involves cell matrix deposition on a 3D titanium (Ti) alloy scaffold. An osteogenic cell source (human periosteum-derived cells) cultured in a bioinstructive medium was used to functionalize regular Ti scaffolds in a perfusion bioreactor, resulting in an osteogenic hybrid carrier. A two-level three-factor fractional factorial design of experiments was employed to explore a range of production-relevant process conditions by simultaneously changing value levels of the following parameters: flow rate (0.5-2 mL/min), cell culture duration (7-21 days), and cell-seeding density (1.5×10(3)-3×10(3) cells/cm(2)). This approach allowed to evaluate the individual impact of the aforementioned process parameters upon key quality attributes of the produced hybrids, such as collagen production, mineralization level, and cell number. The use of a fractional factorial design approach helped create a design space in which hybrid scaffolds of predefined quality attributes may be robustly manufactured while minimizing the number of required experiments.

Small Engine Repair. Two-Stroke and Four-Stroke Cycle.

ERIC Educational Resources Information Center

Hires, Bill; And Others

This curriculum guide is intended to assist persons teaching a course in repairing two- and four-stroke cycle small engines. Addressed in the individual units of instruction are the following topics: safety, tools, fasteners, and measurement techniques; basic small engine theory (engine identification and inspection, basic engine principles and…

Teaching Engineering Habits of Mind in Technology Education

ERIC Educational Resources Information Center

Loveland, Thomas; Dunn, Derrek

2014-01-01

With a new emphasis on the inclusion of engineering content and practices in technology education, attention has focused on what engineering content should be taught and assessed in technology education. The National Academy of Engineering (2010) proposed three general principles for K-12 engineering education in "Standards for K-12…

ThermoData Engine Database

National Institute of Standards and Technology Data Gateway

SRD 103a NIST ThermoData Engine Database (PC database for purchase)   ThermoData Engine is the first product fully implementing all major principles of the concept of dynamic data evaluation formulated at NIST/TRC.

DENTAL PULP TISSUE ENGINEERING

PubMed Central

Demarco, FF; Conde, MCM; Cavalcanti, B; Casagrande, L; Sakai, V; Nör, JE

2013-01-01

Dental pulp is a highly specialized mesenchymal tissue, which have a restrict regeneration capacity due to anatomical arrangement and post-mitotic nature of odontoblastic cells. Entire pulp amputation followed by pulp-space disinfection and filling with an artificial material cause loss of a significant amount of dentin leaving as life-lasting sequelae a non-vital and weakened tooth. However, regenerative endodontics is an emerging field of modern tissue engineering that demonstrated promising results using stem cells associated with scaffolds and responsive molecules. Thereby, this article will review the most recent endeavors to regenerate pulp tissue based on tissue engineering principles and providing insightful information to readers about the different aspects enrolled in tissue engineering. Here, we speculate that the search for the ideal combination of cells, scaffolds, and morphogenic factors for dental pulp tissue engineering may be extended over future years and result in significant advances in other areas of dental and craniofacial research. The finds collected in our review showed that we are now at a stage in which engineering a complex tissue, such as the dental pulp, is no longer an unachievable and the next decade will certainly be an exciting time for dental and craniofacial research. PMID:21519641

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XIV, I--MAINTAINING THE AIR SYSTEM, CUMMINS DIESEL ENGINE, II--UNIT REMOVAL--TRANSMISSION.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES AND MAINTENANCE OF THE DIESEL ENGINE AIR SYSTEM AND THE PROCEDURES FOR TRANSMISSION REMOVAL. TOPICS ARE (1) DEFINITION OF TERMS RELATED TO THE DIESEL AIR SYSTEM, (2) PRNCIPLES OF DIESEL AIR COMPRESSORS, (3) PRINCIPLES OF AIR STARTING MOTORS, (4)…

AUTOMOTIVE DIESEL MAINTENANCE 1, UNIT XVI, I--USE AND CARE OF SMALL HAND TOOLS, II--PRINCIPLES OF THE POWER DIVIDER.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF SMALL HAND TOOLS USED IN DIESEL ENGINE MAINTENANCE AND THE OPERATING PRINCIPLES AND MAINTENANCE OF POWER DIVIDERS (GEAR BOXES) USED IN DIESEL ENGINE POWER DISTRIBUTION. TOPICS ARE (1) UNDERSTANDING TORQUE AND HOW IT IS MEASURED, (2) REPAIRING AND REPLACING THREADED…

A comparison of the role of beamwidth in biological and engineered sonar.

PubMed

Todd, Bryan D; Müller, Rolf

2017-12-28

Sonar is an important sensory modality for engineers as well as in nature. In engineering, sonar is the dominating modality for underwater sensing. In nature, biosonar is likely to have been a central factor behind the unprecedented evolutionary success of bats, a highly diverse group that accounts for over 20% of all mammal species. However, it remains unclear to what extent engineered and biosonar follow similar design and operational principles. In the current work, the key sonar design characteristic of beamwidth is examined in technical and biosonar. To this end, beamwidth data has been obtained for 23 engineered sonar systems and from numerical beampattern predictions for 151 emission and reception elements (noseleaves and ears) representing bat biosonar. Beamwidth data from these sources is compared to the beamwidth of a planar ellipsoidal transducer as a reference. The results show that engineered and biological both obey the basic physical limit on beamwidth as a function of the ratio of aperture size and wavelength. However, beyond that, the beamwidth data revealed very different behaviors between the engineered and the biological sonar systems. Whereas the beamwidths of the technical sonar systems were very close to the planar transducer limit, the biological samples showed a very wide scatter away from this limit. This scatter was as large, if not wider, than what was seen in a small reference data set obtained with random aluminum cones. A possible interpretation of these differences in the variability could be that whereas sonar engineers try to minimize beamwidth subject to constraints on device size, the evolutionary optimization of bat biosonar beampatterns has been directed at other factors that have left beamwidth as a byproduct. Alternatively, the biosonar systems may require beamwidth values that are larger than the physical limit and differ between species and their sensory ecological niches.

Exploring metabolic engineering design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803

PubMed Central

2014-01-01

Background Molecular engineering of the intermediary physiology of cyanobacteria has become important for the sustainable production of biofuels and commodity compounds from CO2 and sunlight by “designer microbes.” The chemical commodity product L-lactic acid can be synthesized in one step from a key intermediary metabolite of these organisms, pyruvate, catalyzed by a lactate dehydrogenase. Synthetic biology engineering to make “designer microbes” includes the introduction and overexpression of the product-forming biochemical pathway. For further optimization of product formation, modifications in the surrounding biochemical network of intermediary metabolism have to be made. Results To improve light-driven L-lactic acid production from CO2, we explored several metabolic engineering design principles, using a previously engineered L-lactic acid producing mutant strain of Synechocystis sp. PCC6803 as the benchmark. These strategies included: (i) increasing the expression level of the relevant product-forming enzyme, lactate dehydrogenase (LDH), for example, via expression from a replicative plasmid; (ii) co-expression of a heterologous pyruvate kinase to increase the flux towards pyruvate; and (iii) knockdown of phosphoenolpyruvate carboxylase to decrease the flux through a competing pathway (from phosphoenolpyruvate to oxaloacetate). In addition, we tested selected lactate dehydrogenases, some of which were further optimized through site-directed mutagenesis to improve the enzyme’s affinity for the co-factor nicotinamide adenine dinucleotide phosphate (NADPH). The carbon partitioning between biomass and lactic acid was increased from about 5% to over 50% by strain optimization. Conclusion An efficient photosynthetic microbial cell factory will display a high rate and extent of conversion of substrate (CO2) into product (here: L-lactic acid). In the existing CO2-based cyanobacterial cell factories that have been described in the literature, by far most of the control over product formation resides in the genetically introduced fermentative pathway. Here we show that a strong promoter, in combination with increased gene expression, can take away a significant part of the control of this step in lactic acid production from CO2. Under these premises, modulation of the intracellular precursor, pyruvate, can significantly increase productivity. Additionally, production enhancement is achieved by protein engineering to increase co-factor specificity of the heterologously expressed LDH. PMID:24991233

Why Industry Must Step In to Train Engineers.

ERIC Educational Resources Information Center

Business Week, 1981

1981-01-01

Suggests industrial training of Japanese engineers since engineering education in Japan focuses on abstract science and rote learning of fundamental principles and not on practical laboratory experiences characteristic of training in the United States. (SK)

The "Difference" in Babbage's Difference Engine.

ERIC Educational Resources Information Center

Crowley, Mary L.

1985-01-01

Discoveries of Charles Babbage in the 1800s are described. Origins of the difference engine, his calculating machine, the principles of computation applied to tables, and the design and construction of his engine are included. (MNS)

Principles of Naval Engineering.

ERIC Educational Resources Information Center

Naval Personnel Program Support Activity, Washington, DC.

Fundamentals of shipboard machinery, equipment, and engineering plants are presented in this text prepared for engineering officers. A general description is included of the development of naval ships, ship design and construction, stability and buoyancy, and damage and casualty control. Engineering theories are explained on the background of ship…

Protein Engineering: Case Studies of Commercialized Engineered Products

ERIC Educational Resources Information Center

Walsh, Gary

2007-01-01

Programs in biochemistry invariably encompass the principles of protein engineering. Students often display increased understanding and enthusiasm when theoretical concepts are underpinned by practical example. Herein are presented five case studies, each focusing upon a commercial protein product engineered to enhance its application-relevant…

Engineering the Follicle Microenvironment

PubMed Central

West, Erin R.; Shea, Lonnie D.; Woodruff, Teresa K.

2008-01-01

In vitro ovarian follicle culture provides a tool to investigate folliculogenesis, and may one day provide women with fertility-preservation options. The application of tissue engineering principles to ovarian follicle maturation may enable the creation of controllable microenvironments that will coordinate the growth of the multiple cellular compartments within the follicle. Three-dimensional culture systems can preserve follicle architecture, thereby maintaining critical cell–cell and cell–matrix signaling lost in traditional two-dimensional attached follicle culture systems. Maintaining the follicular structure while manipulating the biochemical and mechanical environment will enable the development of controllable systems to investigate the fundamental biological principles underlying follicle maturation. This review describes recent advances in ovarian follicle culture, and highlights the tissue engineering principles that may be applied to follicle culture, with the ultimate objective of germline preservation for females facing premature infertility. PMID:17594609

Uterine Tissue Engineering and the Future of Uterus Transplantation.

PubMed

Hellström, Mats; Bandstein, Sara; Brännström, Mats

2017-07-01

The recent successful births following live donor uterus transplantation are proof-of-concept that absolute uterine factor infertility is a treatable condition which affects several hundred thousand infertile women world-wide due to a dysfunctional uterus. This strategy also provides an alternative to gestational surrogate motherhood which is not practiced in most countries due to ethical, religious or legal reasons. The live donor surgery involved in uterus transplantation takes more than 10 h and is then followed by years of immunosuppressive medication to prevent uterine rejection. Immunosuppression is associated with significant adverse side effects, including nephrotoxicity, increased risk of serious infections, and diabetes. Thus, the development of alternative approaches to treat absolute uterine factor infertility would be desirable. This review discusses tissue engineering principles in general, but also details strategies on how to create a bioengineered uterus that could be used for transplantation, without risky donor surgery and any need for immunosuppression. We discuss scaffolds derived from decellularized organs/tissues which may be recellularized using various types of autologous somatic/stem cells, in particular for uterine tissue engineering. It further highlights the hurdles that lay ahead in developing an alternative to an allogeneic source for uterus transplantation.

Leadership in Government Organization Change Efforts: A Multi-Case Analysis

DTIC Science & Technology

2004-09-01

cleared contractor employees on short notice, in the event of demand surges. Letting go of contractor employees was considered a safer bet than...principle can be seen in the early establishment of two reactor plant-engineering laboratories. The strong, competitive capabilities of these two...personnel. The list could extend indefinitely. Application of this principle can be seen in the early establishment of two reactor plant-engineering

Katherine J. Chou | NREL

Science.gov Websites

J. Chou Photo of Katherine J. Chou Katherine Chou Microbial Physiology & Engineering , Clostridium thermocellum, through metabolic engineering. "Biological Electron Transfer and Catalysis principles governing substrate utilization. "Advance Biofuels from Cellulose via Genetic Engineering of

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

Occupational ergonomics and injury prevention.

PubMed

Stobbe, T J

1996-01-01

Ergonomics is the study of people at work. The current focus is on the prevention of work-induced musculoskeletal injuries through the application of sound ergonomic principles. This chapter has briefly outlined ergonomics and its history, has described low back pain and upper extremity cumulative trauma disorders from an ergonomic perspective, and has discussed control and prevention approaches for a few scenarios. Ergonomic principles are based on a combination of science and engineering and a thorough understanding of human capabilities and limitations. When these principles are applied to the design of a job, task, process, or procedure, the incidence and severity of musculoskeletal injuries decrease. In many cases productivity and morale also improve. Workers are spared suffering, and employers are spared costs. It is hoped that this discussion will encourage more health, safety, and business professionals to learn about and apply ergonomics in their workplaces for the improvement of the worker, product, and business. Finally, many additional epidemiologic studies on the individual and joint effects of the CTD risk factors are needed. The knowledge gained from these studies will promote the more effective application of ergonomic principles to reduce worker suffering, improve products, and reduce costs.

Applying design principles to fusion reactor configurations for propulsion in space

NASA Technical Reports Server (NTRS)

Carpenter, Scott A.; Deveny, Marc E.; Schulze, Norman R.

1993-01-01

The application of fusion power to space propulsion requires rethinking the engineering-design solution to controlled-fusion energy. Whereas the unit cost of electricity (COE) drives the engineering-design solution for utility-based fusion reactor configurations; initial mass to low earth orbit (IMLEO), specific jet power (kW(thrust)/kg(engine)), and reusability drive the engineering-design solution for successful application of fusion power to space propulsion. We applied three design principles (DP's) to adapt and optimize three candidate-terrestrial-fusion-reactor configurations for propulsion in space. The three design principles are: provide maximum direct access to space for waste radiation, operate components as passive radiators to minimize cooling-system mass, and optimize the plasma fuel, fuel mix, and temperature for best specific jet power. The three candidate terrestrial fusion reactor configurations are: the thermal barrier tandem mirror (TBTM), field reversed mirror (FRM), and levitated dipole field (LDF). The resulting three candidate space fusion propulsion systems have their IMLEO minimized and their specific jet power and reusability maximized. We performed a preliminary rating of these configurations and concluded that the leading engineering-design solution to space fusion propulsion is a modified TBTM that we call the Mirror Fusion Propulsion System (MFPS).

Health care professional workstation: software system construction using DSSA scenario-based engineering process.

PubMed

Hufnagel, S; Harbison, K; Silva, J; Mettala, E

1994-01-01

This paper describes a new method for the evolutionary determination of user requirements and system specifications called scenario-based engineering process (SEP). Health care professional workstations are critical components of large scale health care system architectures. We suggest that domain-specific software architectures (DSSAs) be used to specify standard interfaces and protocols for reusable software components throughout those architectures, including workstations. We encourage the use of engineering principles and abstraction mechanisms. Engineering principles are flexible guidelines, adaptable to particular situations. Abstraction mechanisms are simplifications for management of complexity. We recommend object-oriented design principles, graphical structural specifications, and formal components' behavioral specifications. We give an ambulatory care scenario and associated models to demonstrate SEP. The scenario uses health care terminology and gives patients' and health care providers' system views. Our goal is to have a threefold benefit. (i) Scenario view abstractions provide consistent interdisciplinary communications. (ii) Hierarchical object-oriented structures provide useful abstractions for reuse, understandability, and long term evolution. (iii) SEP and health care DSSA integration into computer aided software engineering (CASE) environments. These environments should support rapid construction and certification of individualized systems, from reuse libraries.

Report of the Polymer Core Course Committee: Polymer Principles for the Chemical Engineering Curriculum.

ERIC Educational Resources Information Center

Journal of Chemical Education, 1985

1985-01-01

Offers suggestions for introducing polymer topics into: (1) introductory chemical engineering; (2) transport phenomena and unit operations; (3) chemical engineering thermodynamics; and (4) reaction engineering. Also included for each area are examples of textbooks in current use and a few typical problems. (JN)

41 CFR 102-80.135 - Who is a qualified fire protection engineer?

Code of Federal Regulations, 2010 CFR

2010-07-01

... protection engineer? 102-80.135 Section 102-80.135 Public Contracts and Property Management Federal Property... qualified fire protection engineer? A qualified fire protection engineer is defined as an individual with a thorough knowledge and understanding of the principles of physics and chemistry governing fire growth...

Program (systems) engineering

NASA Technical Reports Server (NTRS)

Baroff, Lynn E.; Easter, Robert W.; Pomphrey, Richard B.

2004-01-01

Program Systems Engineering applies the principles of Systems Engineering at the program level. Space programs are composed of interrelated elements which can include collections of projects, advanced technologies, information systems, etc. Some program elements are outside traditional engineering's physical systems, such as education and public outreach, public relations, resource flow, and interactions within the political environments.

A Contemporary Preservice Technology Education Program

ERIC Educational Resources Information Center

Flanigan, Rod; Becker, Kurt; Stewardson, Gary

2012-01-01

In order to teach engineering education, today's engineering and technology education teachers must be equipped with lesson plans to teach engineering design, among other principles, to the 6th-12th grade levels. At Utah State University (USU), curriculum has been developed for preservice engineering and technology education teachers that…

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... vent. (D) Design analysis based on accepted chemical engineering principles, measurable process.... (i) For the purpose of determining de minimis status for emission points, engineering assessment may... operating conditions expected to yield the highest flow rate and concentration. Engineering assessment...

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... vent. (D) Design analysis based on accepted chemical engineering principles, measurable process.... (i) For the purpose of determining de minimis status for emission points, engineering assessment may... operating conditions expected to yield the highest flow rate and concentration. Engineering assessment...

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... vent. (D) Design analysis based on accepted chemical engineering principles, measurable process.... (i) For the purpose of determining de minimis status for emission points, engineering assessment may... operating conditions expected to yield the highest flow rate and concentration. Engineering assessment...

Development and integration of a scalable low NOx combustion chamber for a hydrogen-fueled aerogas turbine

NASA Astrophysics Data System (ADS)

Boerner, S.; Funke, H. H.-W.; Hendrick, P.; Recker, E.; Elsing, R.

2013-03-01

The usage of alternative fuels in aircraft industry plays an important role of current aero engine research and development processes. The micromix burning principle allows a secure and low NOx combustion of gaseous hydrogen. The combustion principle is based on the fluid phenomenon of jet in cross flow and achieves a significant lowering in NOx formation by using multiple miniaturized flames. The paper highlights the development and the integration of a combustion chamber, based on the micromix combustion principle, into an Auxiliary Power Unit (APU) GTCP 36-300 with regard to the necessary modifications on the gas turbine and on the engine controller.

Federal truck size and weight policy : looking beyond the comprehensive truck size and weight study : Irvine, California, May 10-11, 2000

DOT National Transportation Integrated Search

1997-05-01

This document presents a series of five design examples illustrating the principles and methods of geotechnical earthquake engineering and seismic design for highway facilities. These principles and methods are described in Volume I - Design Principl...

Recent advances in bioprinting techniques: approaches, applications and future prospects.

PubMed

Li, Jipeng; Chen, Mingjiao; Fan, Xianqun; Zhou, Huifang

2016-09-20

Bioprinting technology shows potential in tissue engineering for the fabrication of scaffolds, cells, tissues and organs reproducibly and with high accuracy. Bioprinting technologies are mainly divided into three categories, inkjet-based bioprinting, pressure-assisted bioprinting and laser-assisted bioprinting, based on their underlying printing principles. These various printing technologies have their advantages and limitations. Bioprinting utilizes biomaterials, cells or cell factors as a "bioink" to fabricate prospective tissue structures. Biomaterial parameters such as biocompatibility, cell viability and the cellular microenvironment strongly influence the printed product. Various printing technologies have been investigated, and great progress has been made in printing various types of tissue, including vasculature, heart, bone, cartilage, skin and liver. This review introduces basic principles and key aspects of some frequently used printing technologies. We focus on recent advances in three-dimensional printing applications, current challenges and future directions.

An Investigation of Factors Affecting How Engineers and Scientists Seek Information

NASA Technical Reports Server (NTRS)

Anderson, Claire J; Glassman, Myron; McAfee, R. Bruce; Pinelli, Thomas

2001-01-01

This study investigated how 872 US aerospace scientists and engineers select information carriers. When considering oral and written information carriers, the principle of least effort was supported with a strong preference for oral communication over written communication. In examining how the respondents select written carriers, the decision to use or not to use a written carrier was found to be primarily a function of the perceived importance of the carrier's information to a person's work. Task uncertainty and task complexity were found to be significant, but not the primary nor a totally consistent criteria. The perceived quality and accessibility of written carriers were not found significant. The findings reinforce the need for firms to hire knowledgeable employees, to provide them with comprehensive training programs, and to develop formal and informal communication networks.

CRISPR mediated somatic cell genome engineering in the chicken.

PubMed

Véron, Nadège; Qu, Zhengdong; Kipen, Phoebe A S; Hirst, Claire E; Marcelle, Christophe

2015-11-01

Gene-targeted knockout technologies are invaluable tools for understanding the functions of genes in vivo. CRISPR/Cas9 system of RNA-guided genome editing is revolutionizing genetics research in a wide spectrum of organisms. Here, we combined CRISPR with in vivo electroporation in the chicken embryo to efficiently target the transcription factor PAX7 in tissues of the developing embryo. This approach generated mosaic genetic mutations within a wild-type cellular background. This series of proof-of-principle experiments indicate that in vivo CRISPR-mediated cell genome engineering is an effective method to achieve gene loss-of-function in the tissues of the chicken embryo and it completes the growing genetic toolbox to study the molecular mechanisms regulating development in this important animal model. Copyright © 2015 Elsevier Inc. All rights reserved.

The Development of Ada (Trademark) Software for Secure Environments

DTIC Science & Technology

1986-05-23

Telecommunications environment, This paper discusses software socurity and seeks to demostrate how the Ada programming language can be utilizec as a tool...complexity 4 . We use abstraction in our lives every day to control complexity; the principles of abstraction for software engineering are ro different...systems. These features directly sup,) )-t t.ie m odernp software engineering principles d1 s I , , 1 t, thne previous section. This is not surprising

Katherine Young, P.E. | NREL

Science.gov Websites

) Water rights and resources engineering Database planning and development Research Interests Collection lean principles to streamline exploration and drilling and reduce error/risk Research, development and Groundwater modeling Quantitative methods in water resource engineering Water resource engineering and

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters... purpose of determining de minimis status for emission points, engineering assessment may be used to... expected to yield the highest flow rate and concentration. Engineering assessment includes, but is not...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters... purpose of determining de minimis status for emission points, engineering assessment may be used to... expected to yield the highest flow rate and concentration. Engineering assessment includes, but is not...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

Engineering for the 21st century: synthetic biology.

PubMed

Munnelly, Kevin

2013-05-17

For years, scientists have hoped that biology would find its engineering counterpart--a series of principles that could be used as reliably as chemical engineering is for chemistry. Thanks to major advances in synthetic biology, those hopes may soon be realized.

Sustainable Development in Engineering Education

ERIC Educational Resources Information Center

Taoussanidis, Nikolaos N.; Antoniadou, Myrofora A.

2006-01-01

The principles and practice of environmentally and socially sustainable engineering are in line with growing community expectations and the strengthening voice of civil society in engineering interventions. Pressures towards internationalization and globalization are reflected in new course accreditation criteria and higher education structures.…

Diesel Engine Mechanics.

ERIC Educational Resources Information Center

Foutes, William A.

Written in student performance terms, this curriculum guide on diesel engine repair is divided into the following eight sections: an orientation to the occupational field and instructional program; instruction in operating principles; instruction in engine components; instruction in auxiliary systems; instruction in fuel systems; instruction in…

Collaborating with human factors when designing an electronic textbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratner, J.A.; Zadoks, R.I.; Attaway, S.W.

The development of on-line engineering textbooks presents new challenges to authors to effectively integrate text and tools in an electronic environment. By incorporating human factors principles of interface design and cognitive psychology early in the design process, a team at Sandia National Laboratories was able to make the end product more usable and shorten the prototyping and editing phases. A critical issue was simultaneous development of paper and on-line versions of the textbook. In addition, interface consistency presented difficulties with distinct goals and limitations for each media. Many of these problems were resolved swiftly with human factors input using templates,more » style guides and iterative usability testing of both paper and on-line versions. Writing style continuity was also problematic with numerous authors contributing to the text.« less

CF60 Concrete Composition Design and Application on Fudiankou Xijiang Super Large Bridge

NASA Astrophysics Data System (ADS)

Qiu, Yi Mei; Wen, Sen Yuan; Chen, Jun Xiang

2018-06-01

Guangxi Wuzhou City Ring Road Fudiankou Xijiang super large bridge CF60 concrete is a new multi-phase composite high-performance concrete, this paper for the Fudiankou Xijiang bridge structure and characteristics of the project, in accordance with the principle of local materials and technical specification requirements, combined with the site conditions of CF60 engineering high performance concrete component materials, proportion and the technical performance, quantify the main physical and mechanical performance index. Analysis main influencing factors of the technical indicators, reasonable adjustment of concrete mix design parameters, and the use of technical means of admixture and multi-function composite admixture of concrete, obtain the optimal proportion of good work, process, mechanical properties stability and durability of engineering properties, recommend and verification of concrete mix; to explore the CF60 high performance concrete Soil in the Fudiankou Xijiang bridge application technology, detection and tracking the quality of concrete construction, concrete structure during the construction of the key technology and control points is proposed, evaluation of CF60 high performance concrete in the actual engineering application effect and benefit to ensure engineering quality of bridge structure and service life, and super long span bridge engineering construction to provide basis and reference.

Experimental study on distributed optical fiber-based approach monitoring saturation line in levee engineering

NASA Astrophysics Data System (ADS)

Su, Huaizhi; Li, Hao; Kang, Yeyuan; Wen, Zhiping

2018-02-01

Seepage is one of key factors which affect the levee engineering safety. The seepage danger without timely detection and rapid response may likely lead to severe accidents such as seepage failure, slope instability, and even levee break. More than 90 percent of levee break events are caused by the seepage. It is very important for seepage behavior identification to determine accurately saturation line in levee engineering. Furthermore, the location of saturation line has a major impact on slope stability in levee engineering. Considering the structure characteristics and service condition of levee engineering, the distributed optical fiber sensing technology is introduced to implement the real-time observation of saturation line in levee engineering. The distributed optical fiber temperature sensor system (DTS)-based monitoring principle of saturation line in levee engineering is investigated. An experimental platform, which consists of DTS, heating system, water-supply system, auxiliary analysis system and levee model, is designed and constructed. The monitoring experiment of saturation line in levee model is implemented on this platform. According to the experimental results, the numerical relationship between moisture content and thermal conductivity in porous medium is identified. A line heat source-based distributed optical fiber method obtaining the thermal conductivity in porous medium is developed. A DTS-based approach is proposed to monitor the saturation line in levee engineering. The embedment pattern of optical fiber for monitoring saturation line is presented.

A research review of quality assessment for software

NASA Technical Reports Server (NTRS)

1991-01-01

Measures were recommended to assess the quality of software submitted to the AdaNet program. The quality factors that are important to software reuse are explored and methods of evaluating those factors are discussed. Quality factors important to software reuse are: correctness, reliability, verifiability, understandability, modifiability, and certifiability. Certifiability is included because the documentation of many factors about a software component such as its efficiency, portability, and development history, constitute a class for factors important to some users, not important at all to other, and impossible for AdaNet to distinguish between a priori. The quality factors may be assessed in different ways. There are a few quantitative measures which have been shown to indicate software quality. However, it is believed that there exists many factors that indicate quality and have not been empirically validated due to their subjective nature. These subjective factors are characterized by the way in which they support the software engineering principles of abstraction, information hiding, modularity, localization, confirmability, uniformity, and completeness.

Progress in performance enhancement methods for capacitive silicon resonators

NASA Astrophysics Data System (ADS)

Van Toan, Nguyen; Ono, Takahito

2017-11-01

In this paper, we review the progress in recent studies on the performance enhancement methods for capacitive silicon resonators. We provide information on various fabrication technologies and design considerations that can be employed to improve the performance of capacitive silicon resonators, including low motional resistance, small insertion loss, and high quality factor (Q). This paper contains an overview of device structures and working principles, fabrication technologies consisting of hermetic packaging, deep reactive-ion etching and neutral beam etching, and design considerations including mechanically coupled, movable electrode structures and piezoresistive heat engines.

Automotive Engines; Automotive Mechanics I: 9043.03.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

This automotive engines course studies and demonstrates the theory and principles of operation of the automotive four stroke cycle engine. The student will develop an understanding of the systems necessary to make the engine perform as designed, such as cooling, fuel, ignition and lubrication. This is a one or two quinmester credit course of 45…

40 CFR 63.11950 - What emissions calculations must I use for an emission profile?

Code of Federal Regulations, 2012 CFR

2012-07-01

... chemical engineering principles, measurable process parameters, or physical or chemical laws or properties... stream. i = Identifier for a HAP compound. (i) Engineering assessments. You must conduct an engineering... drying or empty vessel purging. An engineering assessment may also be used to support a finding that the...

40 CFR 63.11950 - What emissions calculations must I use for an emission profile?

Code of Federal Regulations, 2013 CFR

2013-07-01

... chemical engineering principles, measurable process parameters, or physical or chemical laws or properties... stream. i = Identifier for a HAP compound. (i) Engineering assessments. You must conduct an engineering... drying or empty vessel purging. An engineering assessment may also be used to support a finding that the...

40 CFR 63.11950 - What emissions calculations must I use for an emission profile?

Code of Federal Regulations, 2014 CFR

2014-07-01

... chemical engineering principles, measurable process parameters, or physical or chemical laws or properties... stream. i = Identifier for a HAP compound. (i) Engineering assessments. You must conduct an engineering... drying or empty vessel purging. An engineering assessment may also be used to support a finding that the...

Auto Mechanics I. Learning Activity Packets (LAPs). Section C--Engine.

ERIC Educational Resources Information Center

Oklahoma State Board of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This document contains five learning activity packets (LAPs) that outline the study activities for the "engine" instructional area for an Auto Mechanics I course. The five LAPs cover the following topics: basic engine principles, cooling system, engine lubrication system, exhaust system, and fuel system. Each LAP contains a cover sheet…

Demonstration Experiments with a Stirling Engine.

ERIC Educational Resources Information Center

Deacon, Christopher G.; And Others

1994-01-01

Describes an investigation with the primary purpose of allowing students to generate and interpret a pressure/volume diagram of a Stirling engine. Explains how the Stirling engine can be used to demonstrate the principles of operation of a refrigerator and a heat pump. (DDR)

Engineering Redox Potential of Lithium Clusters for Electrode Material in Lithium-Ion Batteries

DOE PAGES

Kushwaha, Anoop Kumar; Sahoo, Mihir Ranjan; Nanda, Jagjit; ...

2017-07-01

Low negative electrode potential and high reactivity makes lithium (Li) ideal candidate for obtaining highest possible energy density among other materials. Here, we show a novel route with which the overall electrode potential could significantly be enhanced through selection of cluster size. In using first principles density functional theory and continuum dielectric model, we studied free energy and redox potential as well as investigated relative stability of Li n (n ≤ 8) clusters in both gas phase and solution. We found that Li 3 has the lowest negative redox potential (thereby highest overall electrode potential) suggesting that cluster based approachmore » could provide a novel way of engineering the next generation battery technology. The microscopic origin of Li 3 cluster’s superior performance is related to two major factors: gas phase ionization and difference between solvation free energy for neutral and positive ion. Taken together, our study provides insight into the engineering of redox potential in battery and could stimulate further work in this direction.« less

Engineering Redox Potential of Lithium Clusters for Electrode Material in Lithium-Ion Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kushwaha, Anoop Kumar; Sahoo, Mihir Ranjan; Nanda, Jagjit

Low negative electrode potential and high reactivity makes lithium (Li) ideal candidate for obtaining highest possible energy density among other materials. Here, we show a novel route with which the overall electrode potential could significantly be enhanced through selection of cluster size. In using first principles density functional theory and continuum dielectric model, we studied free energy and redox potential as well as investigated relative stability of Li n (n ≤ 8) clusters in both gas phase and solution. We found that Li 3 has the lowest negative redox potential (thereby highest overall electrode potential) suggesting that cluster based approachmore » could provide a novel way of engineering the next generation battery technology. The microscopic origin of Li 3 cluster’s superior performance is related to two major factors: gas phase ionization and difference between solvation free energy for neutral and positive ion. Taken together, our study provides insight into the engineering of redox potential in battery and could stimulate further work in this direction.« less

Tissue engineering therapies for the vocal fold lamina propria.

PubMed

Kutty, Jaishankar K; Webb, Ken

2009-09-01

The vocal folds are laryngeal connective tissues with complex matrix composition/organization that provide the viscoelastic mechanical properties required for voice production. Vocal fold injury results in alterations in tissue structure and corresponding changes in tissue biomechanics that reduce vocal quality. Recent work has begun to elucidate the biochemical changes underlying injury-induced pathology and to apply tissue engineering principles to the prevention and reversal of vocal fold scarring. Based on the extensive history of injectable biomaterials in laryngeal surgery, a major focus of regenerative therapies has been the development of novel scaffolds with controlled in vivo residence time and viscoelastic properties approximating the native tissue. Additional strategies have included cell transplantation and delivery of the antifibrotic cytokine hepatocyte growth factor, as well as investigation of the effects of the unique vocal fold vibratory microenvironment using in vitro dynamic culture systems. Recent achievements of significant reductions in fibrosis and improved recovery of native tissue viscoelasticity and vibratory/functional performance in animal models are rapidly moving vocal fold tissue engineering toward clinical application.

Method for assessing coal-floor water-inrush risk based on the variable-weight model and unascertained measure theory

NASA Astrophysics Data System (ADS)

Wu, Qiang; Zhao, Dekang; Wang, Yang; Shen, Jianjun; Mu, Wenping; Liu, Honglei

2017-11-01

Water inrush from coal-seam floors greatly threatens mining safety in North China and is a complex process controlled by multiple factors. This study presents a mathematical assessment system for coal-floor water-inrush risk based on the variable-weight model (VWM) and unascertained measure theory (UMT). In contrast to the traditional constant-weight model (CWM), which assigns a fixed weight to each factor, the VWM varies with the factor-state value. The UMT employs the confidence principle, which is more effective in ordered partition problems than the maximum membership principle adopted in the former mathematical theory. The method is applied to the Datang Tashan Coal Mine in North China. First, eight main controlling factors are selected to construct the comprehensive evaluation index system. Subsequently, an incentive-penalty variable-weight model is built to calculate the variable weights of each factor. Then, the VWM-UMT model is established using the quantitative risk-grade divide of each factor according to the UMT. On this basis, the risk of coal-floor water inrush in Tashan Mine No. 8 is divided into five grades. For comparison, the CWM is also adopted for the risk assessment, and a differences distribution map is obtained between the two methods. Finally, the verification of water-inrush points indicates that the VWM-UMT model is powerful and more feasible and reasonable. The model has great potential and practical significance in future engineering applications.

Seven Key Principles of Program and Project Success: A Best Practices Survey

NASA Technical Reports Server (NTRS)

Bilardo, Vincent J.; Korte, John J.; Dankhoff, Walter; Langan, Kevin; Branscome, Darrell R.; Fragola, Joseph R.; Dugal, Dale J.; Gormley, Thomas J.; Hammond, Walter E.; Hollopeter, James J.;

40 CFR 65.64 - Group determination procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... stream volumetric flow shall be corrected to 2.3 percent moisture; or (2) The engineering assessment... section or by using the engineering assessment procedures in paragraph (i) of this section. (1) The net...

40 CFR 65.64 - Group determination procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... stream volumetric flow shall be corrected to 2.3 percent moisture; or (2) The engineering assessment... section or by using the engineering assessment procedures in paragraph (i) of this section. (1) The net...

40 CFR 63.1412 - Continuous process vent applicability assessment procedures and methods.

Code of Federal Regulations, 2010 CFR

2010-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... values, and engineering assessment control applicability assessment requirements are to be determined... by using the engineering assessment procedures in paragraph (k) of this section. (f) Volumetric flow...

40 CFR 63.1412 - Continuous process vent applicability assessment procedures and methods.

Code of Federal Regulations, 2012 CFR

2012-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... values, and engineering assessment control applicability assessment requirements are to be determined... by using the engineering assessment procedures in paragraph (k) of this section. (f) Volumetric flow...

40 CFR 63.1412 - Continuous process vent applicability assessment procedures and methods.

Code of Federal Regulations, 2014 CFR

2014-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... values, and engineering assessment control applicability assessment requirements are to be determined... by using the engineering assessment procedures in paragraph (k) of this section. (f) Volumetric flow...

40 CFR 63.1412 - Continuous process vent applicability assessment procedures and methods.

Code of Federal Regulations, 2013 CFR

2013-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... values, and engineering assessment control applicability assessment requirements are to be determined... by using the engineering assessment procedures in paragraph (k) of this section. (f) Volumetric flow...

40 CFR 63.1412 - Continuous process vent applicability assessment procedures and methods.

Code of Federal Regulations, 2011 CFR

2011-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... values, and engineering assessment control applicability assessment requirements are to be determined... by using the engineering assessment procedures in paragraph (k) of this section. (f) Volumetric flow...

40 CFR 65.64 - Group determination procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... stream volumetric flow shall be corrected to 2.3 percent moisture; or (2) The engineering assessment... section or by using the engineering assessment procedures in paragraph (i) of this section. (1) The net...

40 CFR 65.64 - Group determination procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... stream volumetric flow shall be corrected to 2.3 percent moisture; or (2) The engineering assessment... section or by using the engineering assessment procedures in paragraph (i) of this section. (1) The net...

The Art of Artificial Intelligence. 1. Themes and Case Studies of Knowledge Engineering

DTIC Science & Technology

1977-08-01

in scientific and medical inference illuminate the art of knowledge engineering and its parent science , Artificial Intelligence....The knowledge engineer practices the art of bringing the principles and tools of AI research to bear on difficult applications problems requiring

Low-dimensional transport and large thermoelectric power factors in bulk semiconductors by band engineering of highly directional electronic states.

PubMed

Bilc, Daniel I; Hautier, Geoffroy; Waroquiers, David; Rignanese, Gian-Marco; Ghosez, Philippe

2015-04-03

Thermoelectrics are promising for addressing energy issues but their exploitation is still hampered by low efficiencies. So far, much improvement has been achieved by reducing the thermal conductivity but less by maximizing the power factor. The latter imposes apparently conflicting requirements on the band structure: a narrow energy distribution and a low effective mass. Quantum confinement in nanostructures and the introduction of resonant states were suggested as possible solutions to this paradox, but with limited success. Here, we propose an original approach to fulfill both requirements in bulk semiconductors. It exploits the highly directional character of some orbitals to engineer the band structure and produce a type of low-dimensional transport similar to that targeted in nanostructures, while retaining isotropic properties. Using first-principle calculations, the theoretical concept is demonstrated in Fe2YZ Heusler compounds, yielding power factors 4 to 5 times larger than in classical thermoelectrics at room temperature. Our findings are totally generic and rationalize the search of alternative compounds with similar behavior. Beyond thermoelectricity, these might be relevant also in the context of electronic, superconducting, or photovoltaic applications.

ENVIRONMENTAL HYDRAULICS

EPA Science Inventory

The thermal, chemical, and biological quality of water in rivers, lakes, reservoirs, and near coastal areas is inseparable from a consideration of hydraulic engineering principles: therefore, the term environmental hydraulics. In this chapter we discuss the basic principles of w...

Performance assessment and optimisation of a large information system by combined customer relationship management and resilience engineering: a mathematical programming approach

NASA Astrophysics Data System (ADS)

Azadeh, A.; Foroozan, H.; Ashjari, B.; Motevali Haghighi, S.; Yazdanparast, R.; Saberi, M.; Torki Nejad, M.

2017-10-01

ISs and ITs play a critical role in large complex gas corporations. Many factors such as human, organisational and environmental factors affect IS in an organisation. Therefore, investigating ISs success is considered to be a complex problem. Also, because of the competitive business environment and the high amount of information flow in organisations, new issues like resilient ISs and successful customer relationship management (CRM) have emerged. A resilient IS will provide sustainable delivery of information to internal and external customers. This paper presents an integrated approach to enhance and optimise the performance of each component of a large IS based on CRM and resilience engineering (RE) in a gas company. The enhancement of the performance can help ISs to perform business tasks efficiently. The data are collected from standard questionnaires. It is then analysed by data envelopment analysis by selecting the optimal mathematical programming approach. The selected model is validated and verified by principle component analysis method. Finally, CRM and RE factors are identified as influential factors through sensitivity analysis for this particular case study. To the best of our knowledge, this is the first study for performance assessment and optimisation of large IS by combined RE and CRM.

A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

PubMed Central

Khalil, Ahmad S.; Lu, Timothy K.; Bashor, Caleb J.; Ramirez, Cherie L.; Pyenson, Nora C.; Joung, J. Keith; Collins, James J.

2013-01-01

SUMMARY Eukaryotic transcription factors (TFs) perform complex and combinatorial functions within transcriptional networks. Here, we present a synthetic framework for systematically constructing eukaryotic transcription functions using artificial zinc fingers, modular DNA-binding domains found within many eukaryotic TFs. Utilizing this platform, we construct a library of orthogonal synthetic transcription factors (sTFs) and use these to wire synthetic transcriptional circuits in yeast. We engineer complex functions, such as tunable output strength and transcriptional cooperativity, by rationally adjusting a decomposed set of key component properties, e.g., DNA specificity, affinity, promoter design, protein-protein interactions. We show that subtle perturbations to these properties can transform an individual sTF between distinct roles (activator, cooperative factor, inhibitory factor) within a transcriptional complex, thus drastically altering the signal processing behavior of multi-input systems. This platform provides new genetic components for synthetic biology and enables bottom-up approaches to understanding the design principles of eukaryotic transcriptional complexes and networks. PMID:22863014

Ergonomics and design: its principles applied in the industry.

PubMed

Tavares, Ademario Santos; Silva, Francisco Nilson da

2012-01-01

Industrial Design encompasses both product development and optimization of production process. In this sense, Ergonomics plays a fundamental role, because its principles, methods and techniques can help operators to carry out their tasks most successfully. A case study carried out in an industry shows that the interaction among Design, Production Engineering and Materials Engineering departments may improve some aspects concerned security, comfort, efficiency and performance. In this process, Ergonomics had shown to be of essential importance to strategic decision making to the improvement of production section.

EHV systems technology - A look at the principles and current status. [Electric and Hybrid Vehicle

NASA Technical Reports Server (NTRS)

Kurtz, D. W.; Levin, R. R.

1983-01-01

An examination of the basic principles and practices of systems engineering is undertaken in the context of their application to the component and subsystem technologies involved in electric and hybrid vehicle (EHV) development. The limitations of purely electric vehicles are contrasted with hybrid, heat engine-incorporating vehicle technology, which is inherently more versatile. A hybrid vehicle concept assessment methodology is presented which employs current technology and yet fully satisfies U.S. Department of Energy petroleum displacement goals.

Defense Innovation Unit Experimental (DIUX): Innovative or Excessive

DTIC Science & Technology

2017-04-06

DIUx, and the short history of DIUx. Innovation principles from authors Vijay Govindarajan, Michael Docherty, and Clayton Christensen are then...innovation principles such as performance engine & innovative team, collective / open innovation, and disruptive technology and its implications – is...various innovation principles drawing primarily from work by authors Vijay Govindarajan and Chris Trimble, Michael Docherty, and Clayton Christenson

40 CFR 98.454 - Monitoring and QA/QC requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... using measurements and/or engineering assessments or calculations based on chemical engineering principles or physical or chemical laws or properties. Such assessments or calculations may be based on, as...

40 CFR 98.454 - Monitoring and QA/QC requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... using measurements and/or engineering assessments or calculations based on chemical engineering principles or physical or chemical laws or properties. Such assessments or calculations may be based on, as...

40 CFR 98.454 - Monitoring and QA/QC requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... using measurements and/or engineering assessments or calculations based on chemical engineering principles or physical or chemical laws or properties. Such assessments or calculations may be based on, as...

40 CFR 98.454 - Monitoring and QA/QC requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... using measurements and/or engineering assessments or calculations based on chemical engineering principles or physical or chemical laws or properties. Such assessments or calculations may be based on, as...

40 CFR 35.936-20 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... costs. (b) Appropriate cost principles which apply to subagreements under EPA grants are identified in... engineering services are allowable, even when conducted before award of the grant. Legal and engineering costs...

40 CFR 35.936-20 - Allowable costs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... costs. (b) Appropriate cost principles which apply to subagreements under EPA grants are identified in... engineering services are allowable, even when conducted before award of the grant. Legal and engineering costs...

40 CFR 35.936-20 - Allowable costs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... costs. (b) Appropriate cost principles which apply to subagreements under EPA grants are identified in... engineering services are allowable, even when conducted before award of the grant. Legal and engineering costs...

40 CFR 35.936-20 - Allowable costs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... costs. (b) Appropriate cost principles which apply to subagreements under EPA grants are identified in... engineering services are allowable, even when conducted before award of the grant. Legal and engineering costs...

THE MAN MADE WORLD, TEACHER'S MANUAL.

ERIC Educational Resources Information Center

Commission on Engineering Education, Washington, DC.

THIS TEACHER'S MANUAL FOR THE ENGINEERING CONCEPTS CURRICULUM PROJECT'S HIGH SCHOOL COURSE, "THE MAN MADE WORLD," IS THE THIRD DRAFT OF THE EXPERIMENTAL VERSION. THE MATERIAL WRITTEN BY ENGINEERS, SCIENTISTS, AND EDUCATORS, EMPHASIZES ENGINEERING--MAN'S APPLICATION OF SCIENTIFIC PRINCIPLES TO THE CONTROL AND UTILIZATION OF HIS ENVIRONMENT.…

Is Computer Science Compatible with Technological Literacy?

ERIC Educational Resources Information Center

Buckler, Chris; Koperski, Kevin; Loveland, Thomas R.

2018-01-01

Although technology education evolved over time, and pressure increased to infuse more engineering principles and increase links to STEM (science technology, engineering, and mathematics) initiatives, there has never been an official alignment between technology and engineering education and computer science. There is movement at the federal level…

From Usability Engineering to Evidence-based Usability in Health IT.

PubMed

Marcilly, Romaric; Peute, Linda; Beuscart-Zephir, Marie-Catherine

2016-01-01

Usability is a critical factor in the acceptance, safe use, and success of health IT. The User-Centred Design process is widely promoted to improve usability. However, this traditional case by case approach that is rooted in the sound understanding of users' needs is not sufficient to improve technologies' usability and prevent usability-induced use-errors that may harm patients. It should be enriched with empirical evidence. This evidence is on design elements (what are the most valuable design principles, and the worst usability mistakes), and on the usability evaluation methods (which combination of methods is most suitable in which context). To achieve this evidence, several steps must be fulfilled and challenges must be overcome. Some attempts to search evidence for designing elements of health IT and for usability evaluation methods exist and are summarized. A concrete instance of evidence-based usability design principles for medication-related alerting systems is briefly described.

Fabrication Techniques and Principles for Flat Plate Antennas

DOT National Transportation Integrated Search

1973-09-01

The report documents the fabrication techniques and principles selected to produce one and ten million flat plate antennas per year. An engineering analysis of the reliability, electrical integrity, and repeatability is made, and a cost analysis summ...

Management: The Missing Link to Army Leadership Doctrine

DTIC Science & Technology

2003-01-01

46 B. FUNCTIONS AND PRINCIPLES OF MANAGEMENT ......................... 47 C. EVOLUTION OF COMMAND AND...business. 46 APPENDIX B FUNCTIONS AND PRINCIPLES OF MANAGEMENT Henri Fayol (1841-1925) Henri Fayol, a French engineer and director of mines, was

Career opportunities in clinical engineering.

PubMed

Morse, W A

1992-01-01

The varied career opportunities open to clinical engineers are described in this paper. Many of these opportunities are within the medical device industry in research, development, manufacturing design, regulatory activities, production, operations, sales, marketing, service, and management. Additional opportunities are available in hospitals, with the Veterans Administration, or working as an entrepreneur or a consultant. Each of these careers requires specific training and skills, and they all require a fundamental scientific knowledge of physical principles and mathematics. Research and management, however, require different educational preparation. The research emphasis should be on theoretical principles and creativity; the management emphasis should be on financial and labor problems. In all clinical engineering careers, the individual is a problem solver.

Implementation of a Goal-Based Systems Engineering Process Using the Systems Modeling Language (SysML)

NASA Technical Reports Server (NTRS)

Breckenridge, Jonathan T.; Johnson, Stephen B.

2013-01-01

This paper describes the core framework used to implement a Goal-Function Tree (GFT) based systems engineering process using the Systems Modeling Language. It defines a set of principles built upon by the theoretical approach described in the InfoTech 2013 ISHM paper titled "Goal-Function Tree Modeling for Systems Engineering and Fault Management" presented by Dr. Stephen B. Johnson. Using the SysML language, the principles in this paper describe the expansion of the SysML language as a baseline in order to: hierarchically describe a system, describe that system functionally within success space, and allocate detection mechanisms to success functions for system protection.

40 CFR 63.1414 - Test methods and emission estimation equations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters.... Engineering assessment may be used to estimate organic HAP emissions from a batch emission episode only under... (d)(5) of this section; through engineering assessment, as defined in paragraph (d)(6)(ii) of this...

75 FR 65399 - Petition for Waiver of Compliance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... determination that the engineering principles used in its design of its Continuous Speed Control Yard located at... states that the design elements of the Continuous Speed Control System meets American Railway Engineering... Section 2.4 of the AREMA Manual for Railway Engineering. UP also states that the design of Roseville yard...

Small Engines Care, Operation, Maintenance and Repair. Volume II.

ERIC Educational Resources Information Center

Turner, J. Howard

Developed by teacher educators and agricultural engineers, this teacher and student reference is for use in a course in small engine operation and maintenance. Content includes: (1) Principles of Good Workmanship, (2) Repairing Starters, (3) Maintaining and Repairing Ignition Systems, (4) Repairing Fuel Systems, (5) Repairing Governors, (6)…

Design and Implementation of a Project-Based Active/Cooperative Engineering Design Course for Freshmen

ERIC Educational Resources Information Center

Abdulaal, R. M.; Al-Bahi, A. M.; Soliman, A. Y.; Iskanderani, F. I.

2011-01-01

A project-based active/cooperative design course is planned, implemented, assessed and evaluated to achieve several desired engineering outcomes. The course allows freshman-level students to gain professional hands-on engineering design experience through an opportunity to practise teamwork, quality principles, communication skills, life-long…

Optimization, an Important Stage of Engineering Design

ERIC Educational Resources Information Center

Kelley, Todd R.

2010-01-01

A number of leaders in technology education have indicated that a major difference between the technological design process and the engineering design process is analysis and optimization. The analysis stage of the engineering design process is when mathematical models and scientific principles are employed to help the designer predict design…

Engineering Aid 1 & C. Rate Training Manual.

ERIC Educational Resources Information Center

Naval Education and Training Command, Pensacola, FL.

The manual is written primarily to aid in the training of personnel to meet the professional qualifications of the engineering aid, first class and chief. In chapter one, the trainee becomes familiar with the rewards and responsibilities of an engineering aid. Chapter two deals with principles of SEABEE administration, the organization and…

Teaching Process Engineering Principles Using an Ice Cream Maker

ERIC Educational Resources Information Center

Kaletunc, Gonul; Duemmel, Kevin; Gecik, Christopher

2007-01-01

The ice cream laboratory experiment is designed to illustrate and promote discussion of several engineering and science topics including material and energy balances, heat transfer, freezing, mass transfer, mixing, viscosity, and freezing point depression in a sophomore level engineering class. A pre-lab assignment requires the students to develop…

40 CFR 63.645 - Test methods and procedures for miscellaneous process vents.

Code of Federal Regulations, 2014 CFR

2014-07-01

... applicable to the process vent. (iv) Design analysis based on accepted chemical engineering principles..., dry standard cubic meters per minute, at a temperature of 20 °C. (g) Engineering assessment may be... the highest daily emission rate. (1) Engineering assessment includes, but is not limited to, the...

40 CFR 63.1414 - Test methods and emission estimation equations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters.... Engineering assessment may be used to estimate organic HAP emissions from a batch emission episode only under... (d)(5) of this section; through engineering assessment, as defined in paragraph (d)(6)(ii) of this...

40 CFR 63.1414 - Test methods and emission estimation equations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters.... Engineering assessment may be used to estimate organic HAP emissions from a batch emission episode only under... (d)(5) of this section; through engineering assessment, as defined in paragraph (d)(6)(ii) of this...

40 CFR 63.1414 - Test methods and emission estimation equations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters... paragraph (d)(5) of this section. Engineering assessment may be used to estimate organic HAP emissions from... defined in paragraph (d)(5) of this section; through engineering assessment, as defined in paragraph (d)(6...

40 CFR 63.11925 - What are my initial and continuous compliance requirements for process vents?

Code of Federal Regulations, 2013 CFR

2013-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... scale. (iv) Engineering assessment including, but not limited to, the following: (A) Previous test..., and procedures used in the engineering assessment shall be documented. (3) For miscellaneous process...

40 CFR 63.11925 - What are my initial and continuous compliance requirements for process vents?

Code of Federal Regulations, 2014 CFR

2014-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... scale. (iv) Engineering assessment including, but not limited to, the following: (A) Previous test..., and procedures used in the engineering assessment shall be documented. (3) For miscellaneous process...

40 CFR 63.11925 - What are my initial and continuous compliance requirements for process vents?

Code of Federal Regulations, 2012 CFR

2012-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... scale. (iv) Engineering assessment including, but not limited to, the following: (A) Previous test..., and procedures used in the engineering assessment shall be documented. (3) For miscellaneous process...

40 CFR 63.1414 - Test methods and emission estimation equations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (D) Design analysis based on accepted chemical engineering principles, measurable process parameters... paragraph (d)(5) of this section. Engineering assessment may be used to estimate organic HAP emissions from... defined in paragraph (d)(5) of this section; through engineering assessment, as defined in paragraph (d)(6...

Integration of Sustainability in Engineering Education: Why Is PBL an Answer?

ERIC Educational Resources Information Center

Guerra, Aida

2017-01-01

Purpose: Education for sustainable development (ESD) is one of the challenges engineering education currently faces. Engineering education needs to revise and change its curriculum to integrate ESD principles and knowledge. Problem based learning (PBL) has been one of the main learning pedagogies used to integrate sustainability in engineering…

Learning by Brewing: Beer Production Experiments in the Chemical Engineering Laboratory

ERIC Educational Resources Information Center

Cerretani, Colin; Kelkile, Esayas; Landry, Alexandra

2017-01-01

We discuss the successful creation and implementation of a biotechnology track within the chemical engineering unit operations course. The track focuses on engineering principles relevant to brewing. Following laboratory modules investigating heat transfer processes and yeast fermentation kinetics, student groups design and implement a project to…

Mendel's Modern Legacy

ERIC Educational Resources Information Center

Dixon, James; Kuldell, Natalie

2012-01-01

Genetic engineering is taught in biology--but as a scientific tool and not as a means to explore engineering design. Yet, given the clever behaviors and patterns that can be found when examining living systems, biology classes seem well positioned to teach foundational engineering design principles (Kuldell 2007). This article examines a new,…

Technological Literacy Learning with Cumulative and Stepwise Integration of Equations into Electrical Circuit Diagrams

ERIC Educational Resources Information Center

Ozogul, G.; Johnson, A. M.; Moreno, R.; Reisslein, M.

2012-01-01

Technological literacy education involves the teaching of basic engineering principles and problem solving, including elementary electrical circuit analysis, to non-engineering students. Learning materials on circuit analysis typically rely on equations and schematic diagrams, which are often unfamiliar to non-engineering students. The goal of…

Robot-aided electrospinning toward intelligent biomedical engineering.

PubMed

Tan, Rong; Yang, Xiong; Shen, Yajing

2017-01-01

The rapid development of robotics offers new opportunities for the traditional biofabrication in higher accuracy and controllability, which provides great potentials for the intelligent biomedical engineering. This paper reviews the state of the art of robotics in a widely used biomaterial fabrication process, i.e., electrospinning, including its working principle, main applications, challenges, and prospects. First, the principle and technique of electrospinning are introduced by categorizing it to melt electrospinning, solution electrospinning, and near-field electrospinning. Then, the applications of electrospinning in biomedical engineering are introduced briefly from the aspects of drug delivery, tissue engineering, and wound dressing. After that, we conclude the existing problems in traditional electrospinning such as low production, rough nanofibers, and uncontrolled morphology, and then discuss how those problems are addressed by robotics via four case studies. Lastly, the challenges and outlooks of robotics in electrospinning are discussed and prospected.

Colloquium: Modeling the dynamics of multicellular systems: Application to tissue engineering

NASA Astrophysics Data System (ADS)

Kosztin, Ioan; Vunjak-Novakovic, Gordana; Forgacs, Gabor

2012-10-01

Tissue engineering is a rapidly evolving discipline that aims at building functional tissues to improve or replace damaged ones. To be successful in such an endeavor, ideally, the engineering of tissues should be based on the principles of developmental biology. Recent progress in developmental biology suggests that the formation of tissues from the composing cells is often guided by physical laws. Here a comprehensive computational-theoretical formalism is presented that is based on experimental input and incorporates biomechanical principles of developmental biology. The formalism is described and it is shown that it correctly reproduces and predicts the quantitative characteristics of the fundamental early developmental process of tissue fusion. Based on this finding, the formalism is then used toward the optimization of the fabrication of tubular multicellular constructs, such as a vascular graft, by bioprinting, a novel tissue engineering technology.

Education for Sustainable Development: Assessment of the Current Situation at the Faculty of Engineering of Notre Dame University--Louaize

ERIC Educational Resources Information Center

Salem, Talal; Harb, Jacques

2012-01-01

There is a growing need to incorporate educational sustainable development (ESD) principles into engineering education. This paper identifies engineering competencies within the Faculty of Engineering at Notre Dame University--Louaize and the means to shift towards sustainability. ESD tools are used to carry the analysis, keeping in mind the…

First principles design of a core bioenergetic transmembrane electron-transfer protein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goparaju, Geetha; Fry, Bryan A.; Chobot, Sarah E.

Here we describe the design, Escherichia coli expression and characterization of a simplified, adaptable and functionally transparent single chain 4-α-helix transmembrane protein frame that binds multiple heme and light activatable porphyrins. Such man-made cofactor-binding oxidoreductases, designed from first principles with minimal reference to natural protein sequences, are known as maquettes. This design is an adaptable frame aiming to uncover core engineering principles governing bioenergetic transmembrane electron-transfer function and recapitulate protein archetypes proposed to represent the origins of photosynthesis. This article is part of a Special Issue entitled Biodesign for Bioenergetics — the design and engineering of electronic transfer cofactors, proteinsmore » and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson.« less

Applying Human Factors Principles to Mitigate Usability Issues Related to Embedded Assumptions in Health Information Technology Design

PubMed Central

Lowry, Svetlana Z; Patterson, Emily S

2014-01-01

Background There is growing recognition that design flaws in health information technology (HIT) lead to increased cognitive work, impact workflows, and produce other undesirable user experiences that contribute to usability issues and, in some cases, patient harm. These usability issues may in turn contribute to HIT utilization disparities and patient safety concerns, particularly among “non-typical” HIT users and their health care providers. Health care disparities are associated with poor health outcomes, premature death, and increased health care costs. HIT has the potential to reduce these disparate outcomes. In the computer science field, it has long been recognized that embedded cultural assumptions can reduce the usability, usefulness, and safety of HIT systems for populations whose characteristics differ from “stereotypical” users. Among these non-typical users, inappropriate embedded design assumptions may contribute to health care disparities. It is unclear how to address potentially inappropriate embedded HIT design assumptions once detected. Objective The objective of this paper is to explain HIT universal design principles derived from the human factors engineering literature that can help to overcome potential usability and/or patient safety issues that are associated with unrecognized, embedded assumptions about cultural groups when designing HIT systems. Methods Existing best practices, guidance, and standards in software usability and accessibility were subjected to a 5-step expert review process to identify and summarize those best practices, guidance, and standards that could help identify and/or address embedded design assumptions in HIT that could negatively impact patient safety, particularly for non-majority HIT user populations. An iterative consensus-based process was then used to derive evidence-based design principles from the data to address potentially inappropriate embedded cultural assumptions. Results Design principles that may help identify and address embedded HIT design assumptions are available in the existing literature. Conclusions Evidence-based HIT design principles derived from existing human factors and informatics literature can help HIT developers identify and address embedded cultural assumptions that may underlie HIT-associated usability and patient safety concerns as well as health care disparities. PMID:27025349

Applying Human Factors Principles to Mitigate Usability Issues Related to Embedded Assumptions in Health Information Technology Design.

PubMed

Gibbons, Michael C; Lowry, Svetlana Z; Patterson, Emily S

2014-12-18

There is growing recognition that design flaws in health information technology (HIT) lead to increased cognitive work, impact workflows, and produce other undesirable user experiences that contribute to usability issues and, in some cases, patient harm. These usability issues may in turn contribute to HIT utilization disparities and patient safety concerns, particularly among "non-typical" HIT users and their health care providers. Health care disparities are associated with poor health outcomes, premature death, and increased health care costs. HIT has the potential to reduce these disparate outcomes. In the computer science field, it has long been recognized that embedded cultural assumptions can reduce the usability, usefulness, and safety of HIT systems for populations whose characteristics differ from "stereotypical" users. Among these non-typical users, inappropriate embedded design assumptions may contribute to health care disparities. It is unclear how to address potentially inappropriate embedded HIT design assumptions once detected. The objective of this paper is to explain HIT universal design principles derived from the human factors engineering literature that can help to overcome potential usability and/or patient safety issues that are associated with unrecognized, embedded assumptions about cultural groups when designing HIT systems. Existing best practices, guidance, and standards in software usability and accessibility were subjected to a 5-step expert review process to identify and summarize those best practices, guidance, and standards that could help identify and/or address embedded design assumptions in HIT that could negatively impact patient safety, particularly for non-majority HIT user populations. An iterative consensus-based process was then used to derive evidence-based design principles from the data to address potentially inappropriate embedded cultural assumptions. Design principles that may help identify and address embedded HIT design assumptions are available in the existing literature. Evidence-based HIT design principles derived from existing human factors and informatics literature can help HIT developers identify and address embedded cultural assumptions that may underlie HIT-associated usability and patient safety concerns as well as health care disparities.

Engineering Forum Strategic Plan

EPA Pesticide Factsheets

This Strategic Plan highlights the purpose, mission, goals, and objectives of the U.S. Environmental Protection Agency (EPA) Engineering Forum (EF). It sets forth the principles that guide the EF's decision-making, helps clarify the EF's priorities, and...

2000 report on the value pricing pilot program

DOT National Transportation Integrated Search

1997-05-01

This document has been written to provide information on how to apply principles of geotechnical earthquake engineering to planning, design, and retrofit of highway facilities. Geotechnical earthquake engineering topics discussed in this document inc...

Hidden in plain view: feminists doing engineering ethics, engineers doing feminist ethics.

PubMed

Riley, Donna

2013-03-01

How has engineering ethics addressed gender concerns to date? How have the ideas of feminist philosophers and feminist ethicists made their way into engineering ethics? What might an explicitly feminist engineering ethics look like? This paper reviews some major themes in feminist ethics and then considers three areas in which these themes have been taken up in engineering ethics to date. First, Caroline Whitbeck's work in engineering ethics integrates considerations from her own earlier writings and those of other feminist philosophers, but does not use the feminist label. Second, efforts to incorporate the Ethic of Care and principles of Social Justice into engineering have drawn on feminist scholarship and principles, but these commitments can be lost in translation to the broader engineering community. Third, the film Henry's Daughters brings gender considerations into the mainstream of engineering ethics, but does not draw on feminist ethics per se; despite the best intentions in broaching a difficult subject, the film unfortunately does more harm than good when it comes to sexual harassment education. I seek not only to make the case that engineers should pay attention to feminist ethics and engineering ethicists make more use of feminist ethics traditions in the field, but also to provide some avenues for how to approach integrating feminist ethics in engineering. The literature review and analysis of the three examples point to future work for further developing what might be called feminist engineering ethics.

5 CFR 551.202 - General principles.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... preclude exemption under another category. For example, an engineering technician who fails to meet the...

5 CFR 551.202 - General principles.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... preclude exemption under another category. For example, an engineering technician who fails to meet the...

5 CFR 551.202 - General principles.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... preclude exemption under another category. For example, an engineering technician who fails to meet the...

5 CFR 551.202 - General principles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... preclude exemption under another category. For example, an engineering technician who fails to meet the...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

23 CFR 660.509 - General principles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or any...

Software engineering and the role of Ada: Executive seminar

NASA Technical Reports Server (NTRS)

Freedman, Glenn B.

1987-01-01

The objective was to introduce the basic terminology and concepts of software engineering and Ada. The life cycle model is reviewed. The application of the goals and principles of software engineering is applied. An introductory understanding of the features of the Ada language is gained. Topics addressed include: the software crises; the mandate of the Space Station Program; software life cycle model; software engineering; and Ada under the software engineering umbrella.

Cell-based immunotherapy in gynecologic malignancies.

PubMed

Schaar, Bruce; Krishnan, Venkatesh; Tallapragada, Supreeti; Dorigo, Oliver

2018-02-01

To provide an overview of the principles, safety and efficacy of adoptive cell therapy (ACT) in solid tumors particularly in gynecological cancers. Efforts to target solid tumors using tumor-infiltrating lymphocytes and genetically modified T cells have shown promising efficacy in some patients. Two food and drug administration approvals for the treatment of leukemia are the first gene therapies available for cancer treatment in the United States. Genetic engineering of antitumor immunity using T cells has the potential to target specific tumor-associated antigens and overcome obstacles to successful immunotherapy like immune-suppressive factors in the tumor microenvironment.

Heat engine by exorcism of Maxwell Demon using spin angular momentum reservoir

NASA Astrophysics Data System (ADS)

Bedkihal, Salil; Wright, Jackson; Vaccaro, Joan; Gould, Tim

Landauer's erasure principle is a hallmark in thermodynamics and information theory. According to this principle, erasing one bit of information incurs a minimum energy cost. Recently, Vaccaro and Barnett (VB) have explored the role of multiple conserved quantities in memory erasure. They further illustrated that for the energy degenerate spin reservoirs, the cost of erasure can be solely in terms of spin angular momentum and no energy. Motivated by the VB erasure, in this work we propose a novel optical heat engine that operates under a single thermal reservoir and a spin angular momentum reservoir. The novel heat engine exploits ultrafast processes of phonon absorption to convert thermal phonon energy to coherent light. The entropy generated in this process then corresponds to a mixture of spin up and spin down populations of energy degenerate electronic ground states which acts as demon's memory. This information is then erased using a polarised spin reservoir that acts as an entropy sink. The proposed heat engines goes beyond the traditional Carnot engine.

Box 11: Tissue Engineering and Bioscience Methods Using Proton Beam Writing

NASA Astrophysics Data System (ADS)

van Kan, J. A.

Tissue engineering is a rapidly developing and highly interdisciplinary field that applies the principles of cell biology, engineering, and materials science to the culture of biological tissue. The artificially grown tissue then can be implanted directly into the body, or it can form part of a device that replaces organ functionality.

About Cooperative Engineering: Theory and Emblematic Examples

ERIC Educational Resources Information Center

Morales, Grace; Sensevy, Gérard; Forest, Dominique

2017-01-01

In this article we focus on "cooperative engineering", in which teachers and researchers co-design didactic sequences. In the first part of the article, we present cooperative engineering by describing some of the main principles on which it is grounded. The second part is dedicated to a case study, which enables us to illustrate some…

Incorporating Molecular and Cellular Biology into a Chemical Engineering Degree Program

ERIC Educational Resources Information Center

O'Connor, Kim C.

2005-01-01

There is a growing need for a workforce that can apply engineering principles to molecular based discovery and product development in the biological sciences. To this end, Tulane University established a degree program that incorporates molecular and cellular biology into the chemical engineering curriculum. In celebration of the tenth anniversary…

40 CFR 63.500 - Back-end process provisions-carbon disulfide limitations for styrene butadiene rubber by emulsion...

Code of Federal Regulations, 2010 CFR

2010-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... engineering assessment, as described in paragraph (c)(2) of this section. (1) The owner or operator may choose... run. (2) The owner or operator may use engineering assessment to demonstrate compliance with the...

40 CFR 63.500 - Back-end process provisions-carbon disulfide limitations for styrene butadiene rubber by emulsion...

Code of Federal Regulations, 2013 CFR

2013-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... engineering assessment, as described in paragraph (c)(2) of this section. (1) The owner or operator may choose... run. (2) The owner or operator may use engineering assessment to demonstrate compliance with the...

40 CFR 63.500 - Back-end process provisions-carbon disulfide limitations for styrene butadiene rubber by emulsion...

Code of Federal Regulations, 2012 CFR

2012-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... engineering assessment, as described in paragraph (c)(2) of this section. (1) The owner or operator may choose... run. (2) The owner or operator may use engineering assessment to demonstrate compliance with the...

40 CFR 63.488 - Methods and procedures for batch front-end process vent group determination.

Code of Federal Regulations, 2014 CFR

2014-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... direct measurement as specified in paragraph (b)(5) of this section. Engineering assessment may also be... obtained through direct measurement, as defined in paragraph (b)(5) of this section, through engineering...

40 CFR 63.488 - Methods and procedures for batch front-end process vent group determination.

Code of Federal Regulations, 2012 CFR

2012-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... direct measurement as specified in paragraph (b)(5) of this section. Engineering assessment may also be... obtained through direct measurement, as defined in paragraph (b)(5) of this section, through engineering...

40 CFR 63.645 - Test methods and procedures for miscellaneous process vents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... analysis based on accepted chemical engineering principles, measurable process parameters, or physical or... minute, at a temperature of 20 °C. (g) Engineering assessment may be used to determine the TOC emission...) Engineering assessment includes, but is not limited to, the following: (i) Previous test results provided the...

40 CFR 63.1323 - Batch process vents-methods and procedures for group determination.

Code of Federal Regulations, 2014 CFR

2014-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... paragraph (b)(5) of this section. Engineering assessment may be used to estimate emissions from a batch... defined in paragraph (b)(5) of this section, through engineering assessment, as defined in paragraph (b)(6...

40 CFR 63.645 - Test methods and procedures for miscellaneous process vents.

Code of Federal Regulations, 2013 CFR

2013-07-01

... analysis based on accepted chemical engineering principles, measurable process parameters, or physical or... minute, at a temperature of 20 °C. (g) Engineering assessment may be used to determine the TOC emission...) Engineering assessment includes, but is not limited to, the following: (i) Previous test results provided the...

40 CFR 63.645 - Test methods and procedures for miscellaneous process vents.

Code of Federal Regulations, 2011 CFR

2011-07-01

... analysis based on accepted chemical engineering principles, measurable process parameters, or physical or... minute, at a temperature of 20 °C. (g) Engineering assessment may be used to determine the TOC emission...) Engineering assessment includes, but is not limited to, the following: (i) Previous test results provided the...

40 CFR 63.488 - Methods and procedures for batch front-end process vent group determination.

Code of Federal Regulations, 2013 CFR

2013-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... direct measurement as specified in paragraph (b)(5) of this section. Engineering assessment may also be... obtained through direct measurement, as defined in paragraph (b)(5) of this section, through engineering...

40 CFR 63.1323 - Batch process vents-methods and procedures for group determination.

Code of Federal Regulations, 2011 CFR

2011-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... paragraph (b)(5) of this section. Engineering assessment may be used to estimate emissions from a batch... defined in paragraph (b)(5) of this section, through engineering assessment, as defined in paragraph (b)(6...

40 CFR 63.1323 - Batch process vents-methods and procedures for group determination.

Code of Federal Regulations, 2013 CFR

2013-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... paragraph (b)(5) of this section. Engineering assessment may be used to estimate emissions from a batch... defined in paragraph (b)(5) of this section, through engineering assessment, as defined in paragraph (b)(6...

40 CFR 63.488 - Methods and procedures for batch front-end process vent group determination.

Code of Federal Regulations, 2011 CFR

2011-07-01

... engineering principles, measurable process parameters, or physical or chemical laws or properties. Examples of... direct measurement as specified in paragraph (b)(5) of this section. Engineering assessment may also be... obtained through direct measurement, as defined in paragraph (b)(5) of this section, through engineering...

40 CFR 63.500 - Back-end process provisions-carbon disulfide limitations for styrene butadiene rubber by emulsion...

Code of Federal Regulations, 2011 CFR

2011-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... engineering assessment, as described in paragraph (c)(2) of this section. (1) The owner or operator may choose... run. (2) The owner or operator may use engineering assessment to demonstrate compliance with the...

40 CFR 63.1323 - Batch process vents-methods and procedures for group determination.

Code of Federal Regulations, 2012 CFR

2012-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... paragraph (b)(5) of this section. Engineering assessment may be used to estimate emissions from a batch... defined in paragraph (b)(5) of this section, through engineering assessment, as defined in paragraph (b)(6...

Training Course in Geotechnical and Foundation Engineering. Geotechnical Earthquake Engineering: Reference Manual. Chapters 4, Ground Motion Characterization, and 8, Liquefaction and Seismic Settlement.

DOT National Transportation Integrated Search

1998-12-01

This manual was written to provide training on how to apply principles of geotechnical earthquake engineering to planning, design, and retrofit of highway facilities. Reproduced here are two chapters 4 and 8 in the settlement, respectively. These cha...

Theory of Technical Systems--Educational Tool for Engineering

ERIC Educational Resources Information Center

Eder, Wolfgang Ernst

2016-01-01

Hubka's theory of technical systems (TTS) is briefly outlined. It describes commonalities in all engineering devices, whatever their physical principles of action. This theory is based on a general transformation system (TrfS), which can be used to show engineering in the contexts of society, economics and historic developments. The life cycle of…

A single instrument: engineering and engineering technology students demonstrating competence in ethics and professional standards.

PubMed

Feldhaus, Charles R; Wolter, Robert M; Hundley, Stephen P; Diemer, Tim

2006-04-01

This paper details efforts by the Purdue School of Engineering and Technology at Indiana University Purdue University Indianapolis (IUPUI) to create a single instrument for honors science, technology, engineering and mathematics (STEM) students wishing to demonstrate competence in the IUPUI Principles of Undergraduate Learning (PUL's) and Accreditation Board for Engineering and Technology (ABET) Engineering Accreditation Criterion (EAC) and Technology Accreditation Criterion (TAC) 2, a through k. Honors courses in Human Behavior, Ethical Decision-Making, Applied Leadership, International Issues and Leadership Theories and Processes were created along with a specific menu of activities and an assessment rubric based on PUL's and ABET criteria to evaluate student performance in the aforementioned courses. Students who complete the series of 18 Honors Credit hours are eligible for an Honors Certificate in Leadership Studies from the Department of Organizational Leadership and Supervision. Finally, an accounting of how various university assessment criteria, in this case the IUPUI Principles of Undergraduate Learning, can be linked to ABET outcomes and prove student competence in both, using the aforementioned courses, menu of items, and assessment rubrics; these will be analyzed and discussed.

Who Is Doing the Engineering, the Student or the Teacher? The Development and Use of a Rubric to Categorize Level of Design for the Elementary Classroom

ERIC Educational Resources Information Center

Nadelson, Louis S.; Pfiester, Joshua; Callahan, Janet; Pyke, Patricia

2015-01-01

Science, technology, engineering, and mathematics (STEM) professional development for K-5 teachers often includes engineering design as a focus. Because engineering applications provide perspective to both teachers and their students in terms of how mathematic and scientific principles are employed to solve real-world problems (Baine, 2004; Roden,…

Reliability of ceramics for heat engine applications

NASA Technical Reports Server (NTRS)

1980-01-01

The advantages and disadvantages associated with the use of monolithic ceramics in heat engines are discussed. The principle gaps in the state of understanding of ceramic material, failure origins, nondestructive tests as well as life prediction are included.

TRIZ theory in NEA photocathode preparation system

NASA Astrophysics Data System (ADS)

Qiao, Jianliang; Huang, Dayong; Li, Xiangjiang; Gao, Youtang

2016-09-01

The solutions to the engineering problems were provided according to the innovation principle based on the theory of TRIZ. The ultra high vacuum test and evaluation system for the preparation of negative electron affinity (NEA) photocathode has the characteristics of complex structure and powerful functions. Segmentation principle, advance function principle, curved surface principle, dynamic characteristics principle and nested principle adopted by the design of ultra high vacuum test and evaluation system for cathode preparation were analyzed. The applications of the physical contradiction and the substance-field analysis method of the theory of TRIZ in the cathode preparation ultra high vacuum test and evaluation system were discussed.

Statistical Thermodynamics and Microscale Thermophysics

NASA Astrophysics Data System (ADS)

Carey, Van P.

1999-08-01

Many exciting new developments in microscale engineering are based on the application of traditional principles of statistical thermodynamics. In this text Van Carey offers a modern view of thermodynamics, interweaving classical and statistical thermodynamic principles and applying them to current engineering systems. He begins with coverage of microscale energy storage mechanisms from a quantum mechanics perspective and then develops the fundamental elements of classical and statistical thermodynamics. Subsequent chapters discuss applications of equilibrium statistical thermodynamics to solid, liquid, and gas phase systems. The remainder of the book is devoted to nonequilibrium thermodynamics of transport phenomena and to nonequilibrium effects and noncontinuum behavior at the microscale. Although the text emphasizes mathematical development, Carey includes many examples and exercises to illustrate how the theoretical concepts are applied to systems of scientific and engineering interest. In the process he offers a fresh view of statistical thermodynamics for advanced undergraduate and graduate students, as well as practitioners, in mechanical, chemical, and materials engineering.

Mazda's new V-6 gasoline engine and its innovative induction system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hatamura, K.; Morishita, K.; Asanomi, K.

1987-01-01

Mazda succeeded in the development of a new V-type 6-cylinder engine series comprising 2-liter JF naturally aspirated and turbocharged units and also a 3-liter JE naturally aspirated unit. This engine is 60-degree-banked and has 18 valves: two intake valves and one exhaust valve per cylinder. Various techniques, such as High Rigidity Cylinder Block and HLA, are adopted to upgrade quietness and smoothness. The Dynamic Charge Effects system, a combination of inertia and resonance charge effects, is modeled on the principle of two-degree-of-freedom system. The application of this principle helped develop the Induction system that is compatible with the three enginemore » types. The turbocharger adopted on the JF engine is of a twin scroll type to considerably improve power response quality and increase torque at low speed. Triple Port Induction Control System is used to help improve fuel economy and running performance.« less

Implementing Set Based Design into Department of Defense Acquisition

DTIC Science & Technology

2016-12-01

challenges for the DOD. This report identifies the original SBD principles and characteristics based on Toyota Motor Corporation’s Set Based Concurrent...Engineering Model. Additionally, the team reviewed DOD case studies that implemented SBD. The SBD principles , along with the common themes from the...perennial challenges for the DOD. This report identifies the original SBD principles and characteristics based on Toyota Motor Corporation’s Set

Enhancing light-harvesting power with coherent vibrational interactions: A quantum heat engine picture

NASA Astrophysics Data System (ADS)

Killoran, N.; Huelga, S. F.; Plenio, M. B.

2015-10-01

Recent evidence suggests that quantum effects may have functional importance in biological light-harvesting systems. Along with delocalized electronic excitations, it is now suspected that quantum coherent interactions with certain near-resonant vibrations may contribute to light-harvesting performance. However, the actual quantum advantage offered by such coherent vibrational interactions has not yet been established. We investigate a quantum design principle, whereby coherent exchange of single energy quanta between electronic and vibrational degrees of freedom can enhance a light-harvesting system's power above what is possible by thermal mechanisms alone. We present a prototype quantum heat engine which cleanly illustrates this quantum design principle and quantifies its quantum advantage using thermodynamic measures of performance. We also demonstrate the principle's relevance in parameter regimes connected to natural light-harvesting structures.

Organizational/institutional factors affecting performance in the nuclear power industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, J.L.

1992-01-01

The dramatic macro experiences occurring at Three Mile Island and Chernobyl as well as the cumulative micro experiences represented by sky-rocketing costs and public concerns have demonstrated how the institutionally and organizationally related aspects of the nuclear power industry have dominated and shaped the technical ones. Further, given the relatively stable or evolutionary nature of the technology as it is currently applied, these institutional and organizational factors contain the roots of most of the complications/problems associated with the industry relative to achieving any or all of its future performance objectives (technical, economic, and safety). Some technology transfer was attempted bymore » the author from the field of general systems/cybernetics, which was explicitly aimed at dealing with the organizational/institutional factors, i.e., the problems and issues were approached using principles and methodology substantially different from that typically seen from applications based on the more traditional paradigmic engineering/industrial management orientation.« less

An overlooked alliance: using human factors engineering to reduce patient harm.

PubMed

Perry, Shawna J

2004-08-01

Although human factors engineering (HFE) is considered only in relationship to the design of medical devices or information systems technology, human factors issues arise in many aspects of work in health care organizations. In one scenario, the resuscitation stretcher would not pass through the ED door closest to radiology. Many clinical work spaces were never formally designed for the work currently being performed in them; instead, they were adapted from existing space originally designed for a different use. In a second scenario, infusion pump malfunction was not apparent. The patient experienced a near miss secondary to poor design; users thought that the infusion pump had been turned off when it was not. Health care can significantly benefit from the incorporation of HFE into the workplace. Introductory classes in medical and nursing schools on HFE will assist students in detecting HFE-related issues, making them less likely to suffer with them or overlook them once in clinical practice. More extensive training for patient safety and risk managers, that is, at a minimum, a certificate-level course from an HFE program, would enhance case and root cause analyses since these issues are rarely factored in. Collaboration with HFE experts and use of HFE principles may not make health care fool-proof, but it will make it less dependent on improvisation and ingenuity to protect patients from the system's vulnerabilities.

Scale Up in Education. Volume 1: Ideas in Principle

ERIC Educational Resources Information Center

Schneider, Barbara Ed.; McDonald, Sarah-Kathryn Ed.

2006-01-01

"Scale Up in Education, Volume 1: Ideas in Principle" examines the challenges of "scaling up" from a multidisciplinary perspective. It brings together contributions from disciplines that routinely take promising innovations to scale, including medicine, business, engineering, computing, and education. Together the contributors explore appropriate…

Detection on vehicle vibration induced by the engine shaking based on the laser triangulation

NASA Astrophysics Data System (ADS)

Chen, Wenxue; Yang, Biwu; Ni, Zhibin; Hu, Xinhan; Han, Tieqiang; Hu, Yaocheng; Zhang, Wu; Wang, Yunfeng

2017-10-01

The magnitude of engine shaking is chosen to evaluate the vehicle performance. The engine shaking is evaluated by the vehicle vibration. Based on the laser triangulation, the vehicle vibration is measured by detecting the distance variation between the bodywork and road surface. The results represent the magnitude of engine shaking. The principle and configuration of the laser triangulation is also introduced in this paper.

Characterisation

DTIC Science & Technology

2007-03-01

Characterisation. In Nanotechnology Aerospace Applications – 2006 (pp. 4-1 – 4-8). Educational Notes RTO-EN-AVT-129bis, Paper 4. Neuilly-sur-Seine, France: RTO...the Commercialisation Processes Concept IDEA Proof-of- Principle Trial Samples Engineering Verification Samples Design Verification Samples...SEIC Systems Engineering for commercialisation Design Houses, Engineering & R&D USERS & Integrators SE S U R Integrators Fabs & Wafer Processing Die

40 CFR 63.500 - Back-end process provisions-carbon disulfide limitations for styrene butadiene rubber by emulsion...

Code of Federal Regulations, 2014 CFR

2014-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... engineering assessment, as described in paragraph (c)(2) of this section. (1) The owner or operator may choose... sample run. (2) The owner or operator may use engineering assessment to demonstrate compliance with the...

A Guideline of Using Case Method in Software Engineering Courses

ERIC Educational Resources Information Center

Zainal, Dzulaiha Aryanee Putri; Razali, Rozilawati; Shukur, Zarina

2014-01-01

Software Engineering (SE) education has been reported to fall short in producing high quality software engineers. In seeking alternative solutions, Case Method (CM) is regarded as having potential to solve the issue. CM is a teaching and learning (T&L) method that has been found to be effective in Social Science education. In principle,…

Assessing the Value-Added by the Environmental Testing Process with the Aide of Physics/Engineering of Failure Evaluations

NASA Technical Reports Server (NTRS)

Cornford, S.; Gibbel, M.

1997-01-01

NASA's Code QT Test Effectiveness Program is funding a series of applied research activities focused on utilizing the principles of physics and engineering of failure and those of engineering economics to assess and improve the value-added by the various validation and verification activities to organizations.

High-energy mode-locked fiber lasers using multiple transmission filters and a genetic algorithm.

PubMed

Fu, Xing; Kutz, J Nathan

2013-03-11

We theoretically demonstrate that in a laser cavity mode-locked by nonlinear polarization rotation (NPR) using sets of waveplates and passive polarizer, the energy performance can be significantly increased by incorporating multiple NPR filters. The NPR filters are engineered so as to mitigate the multi-pulsing instability in the laser cavity which is responsible for limiting the single pulse per round trip energy in a myriad of mode-locked cavities. Engineering of the NPR filters for performance is accomplished by implementing a genetic algorithm that is capable of systematically identifying viable and optimal NPR settings in a vast parameter space. Our study shows that five NPR filters can increase the cavity energy by approximately a factor of five, with additional NPRs contributing little or no enhancements beyond this. With the advent and demonstration of electronic controls for waveplates and polarizers, the analysis suggests a general design and engineering principle that can potentially close the order of magnitude energy gap between fiber based mode-locked lasers and their solid state counterparts.

A Principle of Intentionality.

PubMed

Turner, Charles K

2017-01-01

The mainstream theories and models of the physical sciences, including neuroscience, are all consistent with the principle of causality. Wholly causal explanations make sense of how things go, but are inherently value-neutral, providing no objective basis for true beliefs being better than false beliefs, nor for it being better to intend wisely than foolishly. Dennett (1987) makes a related point in calling the brain a syntactic (procedure-based) engine. He says that you cannot get to a semantic (meaning-based) engine from there. He suggests that folk psychology revolves around an intentional stance that is independent of the causal theories of the brain, and accounts for constructs such as meanings, agency, true belief, and wise desire. Dennett proposes that the intentional stance is so powerful that it can be developed into a valid intentional theory. This article expands Dennett's model into a principle of intentionality that revolves around the construct of objective wisdom. This principle provides a structure that can account for all mental processes, and for the scientific understanding of objective value. It is suggested that science can develop a far more complete worldview with a combination of the principles of causality and intentionality than would be possible with scientific theories that are consistent with the principle of causality alone.

A Principle of Intentionality

PubMed Central

Turner, Charles K.

2017-01-01

The mainstream theories and models of the physical sciences, including neuroscience, are all consistent with the principle of causality. Wholly causal explanations make sense of how things go, but are inherently value-neutral, providing no objective basis for true beliefs being better than false beliefs, nor for it being better to intend wisely than foolishly. Dennett (1987) makes a related point in calling the brain a syntactic (procedure-based) engine. He says that you cannot get to a semantic (meaning-based) engine from there. He suggests that folk psychology revolves around an intentional stance that is independent of the causal theories of the brain, and accounts for constructs such as meanings, agency, true belief, and wise desire. Dennett proposes that the intentional stance is so powerful that it can be developed into a valid intentional theory. This article expands Dennett’s model into a principle of intentionality that revolves around the construct of objective wisdom. This principle provides a structure that can account for all mental processes, and for the scientific understanding of objective value. It is suggested that science can develop a far more complete worldview with a combination of the principles of causality and intentionality than would be possible with scientific theories that are consistent with the principle of causality alone. PMID:28223954

33 CFR 385.9 - Implementation principles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Responsibilities § 385.9 Implementation principles. The Corps of Engineers and the South Florida Water Management...) Endorsement of the Plan as a restoration framework is not intended as a constraint on innovation during implementation through the adaptive management process. Continuous improvement of the Plan shall be sought to...

Some Remarks on the Improvement of Engineering Education

NASA Astrophysics Data System (ADS)

Tribus, Myron

2005-03-01

This paper combines the quality management principles of Deming with the educational theories of Feuerstein and Bloom in the design of a system of engineering education in which every student, on graduation, will display mastery of the subjects in the curriculum.

Some Remarks on the Improvement of Engineering Education

ERIC Educational Resources Information Center

Tribus, Myron

2005-01-01

This paper combines the quality management principles of Deming with the educational theories of Feuerstein and Bloom in the design of a system of engineering education in which every student, on graduation, will display mastery of the subjects in the curriculum.

A review of human factors principles for the design and implementation of medication safety alerts in clinical information systems.

PubMed

Phansalkar, Shobha; Edworthy, Judy; Hellier, Elizabeth; Seger, Diane L; Schedlbauer, Angela; Avery, Anthony J; Bates, David W

2010-01-01

The objective of this review is to describe the implementation of human factors principles for the design of alerts in clinical information systems. First, we conduct a review of alarm systems to identify human factors principles that are employed in the design and implementation of alerts. Second, we review the medical informatics literature to provide examples of the implementation of human factors principles in current clinical information systems using alerts to provide medication decision support. Last, we suggest actionable recommendations for delivering effective clinical decision support using alerts. A review of studies from the medical informatics literature suggests that many basic human factors principles are not followed, possibly contributing to the lack of acceptance of alerts in clinical information systems. We evaluate the limitations of current alerting philosophies and provide recommendations for improving acceptance of alerts by incorporating human factors principles in their design.

Review of jet engine emissions

NASA Technical Reports Server (NTRS)

Grobman, J. S.

1972-01-01

A review of the emission characteristics of jet engines is presented. The sources and concentrations of the various constituents in the engine exhaust and the influence of engine operating conditions on emissions are discussed. Cruise emissions to be expected from supersonic engines are compared with emissions from subsonic engines. The basic operating principles of the gas turbine combustor are reviewed together with the effects of combustor operating conditions on emissions. The performance criteria that determine the design of gas turbine combustors are discussed. Combustor design techniques are considered that may be used to reduce emissions.

Manufacturing engineering: Principles for optimization

NASA Astrophysics Data System (ADS)

Koenig, Daniel T.

Various subjects in the area of manufacturing engineering are addressed. The topics considered include: manufacturing engineering organization concepts and management techniques, factory capacity and loading techniques, capital equipment programs, machine tool and equipment selection and implementation, producibility engineering, methods, planning and work management, and process control engineering in job shops. Also discussed are: maintenance engineering, numerical control of machine tools, fundamentals of computer-aided design/computer-aided manufacture, computer-aided process planning and data collection, group technology basis for plant layout, environmental control and safety, and the Integrated Productivity Improvement Program.

Computing in Hydraulic Engineering Education

NASA Astrophysics Data System (ADS)

Duan, J. G.

2011-12-01

Civil engineers, pioneers of our civilization, are rarely perceived as leaders and innovators in modern society because of retardations in technology innovation. This crisis has resulted in the decline of the prestige of civil engineering profession, reduction of federal funding on deteriorating infrastructures, and problems with attracting the most talented high-school students. Infusion of cutting-edge computer technology and stimulating creativity and innovation therefore are the critical challenge to civil engineering education. To better prepare our graduates to innovate, this paper discussed the adaption of problem-based collaborative learning technique and integration of civil engineering computing into a traditional civil engineering curriculum. Three interconnected courses: Open Channel Flow, Computational Hydraulics, and Sedimentation Engineering, were developed with emphasis on computational simulations. In Open Channel flow, the focuses are principles of free surface flow and the application of computational models. This prepares students to the 2nd course, Computational Hydraulics, that introduce the fundamental principles of computational hydraulics, including finite difference and finite element methods. This course complements the Open Channel Flow class to provide students with in-depth understandings of computational methods. The 3rd course, Sedimentation Engineering, covers the fundamentals of sediment transport and river engineering, so students can apply the knowledge and programming skills gained from previous courses to develop computational models for simulating sediment transport. These courses effectively equipped students with important skills and knowledge to complete thesis and dissertation research.

Computational modeling for eco engineering: Making the connections between engineering and ecology (Invited)

NASA Astrophysics Data System (ADS)

Bowles, C.

2013-12-01

Ecological engineering, or eco engineering, is an emerging field in the study of integrating ecology and engineering, concerned with the design, monitoring, and construction of ecosystems. According to Mitsch (1996) 'the design of sustainable ecosystems intends to integrate human society with its natural environment for the benefit of both'. Eco engineering emerged as a new idea in the early 1960s, and the concept has seen refinement since then. As a commonly practiced field of engineering it is relatively novel. Howard Odum (1963) and others first introduced it as 'utilizing natural energy sources as the predominant input to manipulate and control environmental systems'. Mtisch and Jorgensen (1989) were the first to define eco engineering, to provide eco engineering principles and conceptual eco engineering models. Later they refined the definition and increased the number of principles. They suggested that the goals of eco engineering are: a) the restoration of ecosystems that have been substantially disturbed by human activities such as environmental pollution or land disturbance, and b) the development of new sustainable ecosystems that have both human and ecological values. Here a more detailed overview of eco engineering is provided, particularly with regard to how engineers and ecologists are utilizing multi-dimensional computational models to link ecology and engineering, resulting in increasingly successful project implementation. Descriptions are provided pertaining to 1-, 2- and 3-dimensional hydrodynamic models and their use at small- and large-scale applications. A range of conceptual models that have been developed to aid the in the creation of linkages between ecology and engineering are discussed. Finally, several case studies that link ecology and engineering via computational modeling are provided. These studies include localized stream rehabilitation, spawning gravel enhancement on a large river system, and watershed-wide floodplain modeling of the Sacramento River Valley.

On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology.

PubMed

Rao, Rohit T; Scherholz, Megerle L; Hartmanshenn, Clara; Bae, Seul-A; Androulakis, Ioannis P

2017-12-05

The use of models in biology has become particularly relevant as it enables investigators to develop a mechanistic framework for understanding the operating principles of living systems as well as in quantitatively predicting their response to both pathological perturbations and pharmacological interventions. This application has resulted in a synergistic convergence of systems biology and pharmacokinetic-pharmacodynamic modeling techniques that has led to the emergence of quantitative systems pharmacology (QSP). In this review, we discuss how the foundational principles of chemical process systems engineering inform the progressive development of more physiologically-based systems biology models.

Bioinspired principles for large-scale networked sensor systems: an overview.

PubMed

Jacobsen, Rune Hylsberg; Zhang, Qi; Toftegaard, Thomas Skjødeberg

2011-01-01

Biology has often been used as a source of inspiration in computer science and engineering. Bioinspired principles have found their way into network node design and research due to the appealing analogies between biological systems and large networks of small sensors. This paper provides an overview of bioinspired principles and methods such as swarm intelligence, natural time synchronization, artificial immune system and intercellular information exchange applicable for sensor network design. Bioinspired principles and methods are discussed in the context of routing, clustering, time synchronization, optimal node deployment, localization and security and privacy.

AGARD Flight Test Instrumentation Series. Volume 1, Issue 2. Basic Principles of Flight Test Instrumentation Engineering (Introduction Generale aux Principles de Base de l’Instrumentation des Essais en Vol)

DTIC Science & Technology

1994-03-01

evaluation of its anticipated value. If the program can be accomplished using conventional techniques , this should be seriously considered. Development or...the direct frequency generating principles such as, pulse tachos, turbine flowmeters, and encoders, also Doppler and laser techniques used for...CERAMIC BLOCK Figure 5.3. The basic concepts of the laser ring gyro (LRG). The principle depends upon the guidance of two beams of laser light around an

Clarity of objectives and working principles enhances the success of biomimetic programs.

PubMed

Wolff, Jonas O; Wells, David; Reid, Chris R; Blamires, Sean J

2017-09-26

Biomimetics, the transfer of functional principles from living systems into product designs, is increasingly being utilized by engineers. Nevertheless, recurring problems must be overcome if it is to avoid becoming a short-lived fad. Here we assess the efficiency and suitability of methods typically employed by examining three flagship examples of biomimetic design approaches from different disciplines: (1) the creation of gecko-inspired adhesives; (2) the synthesis of spider silk, and (3) the derivation of computer algorithms from natural self-organizing systems. We find that identification of the elemental working principles is the most crucial step in the biomimetic design process. It bears the highest risk of failure (e.g. losing the target function) due to false assumptions about the working principle. Common problems that hamper successful implementation are: (i) a discrepancy between biological functions and the desired properties of the product, (ii) uncertainty about objectives and applications, (iii) inherent limits in methodologies, and (iv) false assumptions about the biology of the models. Projects that aim for multi-functional products are particularly challenging to accomplish. We suggest a simplification, modularisation and specification of objectives, and a critical assessment of the suitability of the model. Comparative analyses, experimental manipulation, and numerical simulations followed by tests of artificial models have led to the successful extraction of working principles. A searchable database of biological systems would optimize the choice of a model system in top-down approaches that start at an engineering problem. Only when biomimetic projects become more predictable will there be wider acceptance of biomimetics as an innovative problem-solving tool among engineers and industry.

Tracing organizing principles: learning from the history of systems biology.

PubMed

Green, Sara; Wolkenhauer, Olaf

2013-01-01

With the emergence of systems biology, the identification of organizing principles is being highlighted as a key research aim. Researchers attempt to "reverse engineer" the functional organization of biological systems using methodologies from mathematics, engineering and computer science while taking advantage of data produced by new experimental techniques. While systems biology is a relatively new approach, the quest for general principles of biological organization dates back to systems theoretic approaches in early and mid-twentieth century. The aim of this paper is to draw on this historical background in order to increase the understanding of the motivation behind the search for general principles and to clarify different epistemic aims within systems biology. We pinpoint key aspects of earlier approaches that also underlie the current practice. These are i) the focus on relational and system-level properties, ii) the inherent critique of reductionism and fragmentation of knowledge resulting from overspecialization, and iii) the insight that the ideal of formulating abstract organizing principles is complementary to, rather than conflicting with, the aim of formulating detailed explanations of biological mechanisms. We argue that looking back not only helps us understand the current practice but also points to possible future directions for systems biology.

Principles and Practices Fostering Inclusive Excellence: Lessons from the Howard Hughes Medical Institute's Capstone Institutions

ERIC Educational Resources Information Center

DiBartolo, Patricia Marten; Gregg-Jolly, Leslie; Gross, Deborah; Manduca, Cathryn A.; Iverson, Ellen; Cooke, David B., III; Davis, Gregory K.; Davidson, Cameron; Hertz, Paul E.; Hibbard, Lisa; Ireland, Shubha K.; Mader, Catherine; Pai, Aditi; Raps, Shirley; Siwicki, Kathleen; Swartz, Jim E.

2016-01-01

Best-practices pedagogy in science, technology, engineering, and mathematics (STEM) aims for inclusive excellence that fosters student persistence. This paper describes principles of inclusivity across 11 primarily undergraduate institutions designated as Capstone Awardees in Howard Hughes Medical Institute's (HHMI) 2012 competition. The Capstones…

Improving FCS Accountability: Increasing STEM Awareness with Interior Design Modules

ERIC Educational Resources Information Center

Etheredge, Jessica; Moody, Dana; Cooper, Ashley

2014-01-01

This paper demonstrates ways in which family and consumer sciences (FCS) educators can explore more opportunities to integrate Science, Technology, Engineering, and Math (STEM) principles into secondary education curriculum. Interior design is used as a case study for creating learning modules that incorporate STEM principles in a creative and…

Bridging Levels of Analysis: Learning, Information Theory, and the Lexicon

ERIC Educational Resources Information Center

Dye, Melody

2017-01-01

While information theory is typically considered in the context of modern computing and engineering, its core mathematical principles provide a potentially useful lens through which to consider human language. Like the artificial communication systems such principles were invented to describe, natural languages involve a sender and receiver, a…

First-Hand Experience with Engineering Design and Career Interest in Engineering: An Informal STEM Education Case Study

ERIC Educational Resources Information Center

Ayar, Mehmet C.

2015-01-01

The purpose of this study is to present students' experiences, interest in engineering, and personal narratives while participating in a robotics summer camp in a metropolitan city in Turkey. In this study, I used qualitative data collection methods such as interviews, field notes, and observations. I used the four principles of Engle and Conant…

Increasing the Roles and Significance of Teachers in Policymaking for K-12 Engineering Education: Proceedings of a Convocation

ERIC Educational Resources Information Center

Olson, Steve

2017-01-01

Engineering is a small but growing part of K-12 education. Curricula that use the principles and practices of engineering are providing opportunities for elementary, middle, and high school students to design solutions to problems of immediate practical and societal importance. Professional development programs are showing teachers how to use…

40 CFR 92.102 - Definitions and abbreviations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... engineering practice. Calibration means the act of calibrating an analytical instrument using known standards... be consistent with scientific and engineering principles. Hang-up refers to the process of... reaching the instrument detector. It also refers to any subsequent desorption of the molecules into the...

The Contribution of Cognitive Engineering to the Effective Design and Use of Information Systems.

ERIC Educational Resources Information Center

Garg-Janardan, Chaya; Salvendy, Gavriel

1986-01-01

Examines the role of human information processing and decision-making capabilities and limitations in the design of effective human-computer interfaces. Several cognitive engineering principles that should guide the design process are outlined. (48 references) (Author/CLB)

Toward an Engineering Model for the Aerodynamic Forces Acting on Wind Turbine Blades in Quasisteady Standstill and Blade Installation Situations

NASA Astrophysics Data System (ADS)

Gaunaa, Mac; Heinz, Joachim; Skrzypiński, Witold

2016-09-01

The crossflow principle is one of the key elements used in engineering models for prediction of the aerodynamic loads on wind turbine blades in standstill or blade installation situations, where the flow direction relative to the wind turbine blade has a component in the direction of the blade span direction. In the present work, the performance of the crossflow principle is assessed on the DTU 10MW reference blade using extensive 3D CFD calculations. Analysis of the computational results shows that there is only a relatively narrow region in which the crossflow principle describes the aerodynamic loading well. In some conditions the deviation of the predicted loadings can be quite significant, having a large influence on for instance the integral aerodynamic moments around the blade centre of mass; which is very important for single blade installation applications. The main features of these deviations, however, have a systematic behaviour on all force components, which in this paper is employed to formulate the first version of an engineering correction method to the crossflow principle applicable for wind turbine blades. The new correction model improves the agreement with CFD results for the key aerodynamic loads in crossflow situations. The general validity of this model for other blade shapes should be investigated in subsequent works.

Preparing technicians for engineering materials technology

NASA Technical Reports Server (NTRS)

Jacobs, James A.; Metzloff, Carlton H.

1990-01-01

A long held principle is that for every engineer and scientist there is a need for ten technicians to maximize the efficiency of the technology team for meeting needs of industry and government. Developing an adequate supply of technicians to meet the requirements of the materials related industry will be a challenge and difficult to accomplish. A variety of agencies feel the need and wish to support development of engineering materials technology programs. In a joint effort among Battelle Laboratories, the Department of Energy (DOE) and Northwest College and University Association for Science (NORCUS), the development of an engineering materials technology program for vocational programs and community colleges for the Pacific Northwest Region was recently completed. This effort has implications for a national model. The model Associate of Applied Science degree in Engineering Materials Technology shown provides a general structure. It purposely has course titles which need delimiting while also including a core of courses necessary to develop cognitive, affective and psychomotor skills with the underlining principles of math, science and technology so students have job entry skills, and so that students can learn about and adapt to evolving technology.

Cross-hierarchy systems principles.

PubMed

Goentoro, Lea

2017-02-01

One driving motivation of systems biology is the search for general principles that govern the design of biological systems. But questions often arise as to what kind of general principles biology could have. Concepts from engineering such as robustness and modularity are indeed becoming a regular way of describing biological systems. Another source of potential general principles is the emerging similarities found in processes across biological hierarchies. In this piece, I describe several emerging cross-hierarchy similarities. Identification of more cross-hierarchy principles, and understanding the implications these convergence have on the construction of biological systems, I believe, present exciting challenges for systems biology in the decades to come.

Principle of maximum entropy for reliability analysis in the design of machine components

NASA Astrophysics Data System (ADS)

Zhang, Yimin

2018-03-01

We studied the reliability of machine components with parameters that follow an arbitrary statistical distribution using the principle of maximum entropy (PME). We used PME to select the statistical distribution that best fits the available information. We also established a probability density function (PDF) and a failure probability model for the parameters of mechanical components using the concept of entropy and the PME. We obtained the first four moments of the state function for reliability analysis and design. Furthermore, we attained an estimate of the PDF with the fewest human bias factors using the PME. This function was used to calculate the reliability of the machine components, including a connecting rod, a vehicle half-shaft, a front axle, a rear axle housing, and a leaf spring, which have parameters that typically follow a non-normal distribution. Simulations were conducted for comparison. This study provides a design methodology for the reliability of mechanical components for practical engineering projects.

Application of the GA-BP Neural Network in Earthwork Calculation

NASA Astrophysics Data System (ADS)

Fang, Peng; Cai, Zhixiong; Zhang, Ping

2018-01-01

The calculation of earthwork quantity is the key factor to determine the project cost estimate and the optimization of the scheme. It is of great significance and function in the excavation of earth and rock works. We use optimization principle of GA-BP intelligent algorithm running process, and on the basis of earthwork quantity and cost information database, the design of the GA-BP neural network intelligent computing model, through the network training and learning, the accuracy of the results meet the actual engineering construction of gauge fan requirements, it provides a new approach for other projects the calculation, and has good popularization value.

Delivery of Brain-Derived Neurotrophic Factor by 3D Biocompatible Polymeric Scaffolds for Neural Tissue Engineering and Neuronal Regeneration.

PubMed

Limongi, T; Rocchi, A; Cesca, F; Tan, H; Miele, E; Giugni, A; Orlando, M; Perrone Donnorso, M; Perozziello, G; Benfenati, Fabio; Di Fabrizio, Enzo

2018-03-29

Biopolymers are increasingly employed for neuroscience applications as scaffolds to drive and promote neural regrowth, thanks to their ability to mediate the upload and subsequent release of active molecules and drugs. Synthetic degradable polymers are characterized by different responses ranging from tunable distension or shrinkage to total dissolution, depending on the function they are designed for. In this paper we present a biocompatible microfabricated poly-ε-caprolactone (PCL) scaffold for primary neuron growth and maturation that has been optimized for the in vitro controlled release of brain-derived neurotrophic factor (BDNF). We demonstrate that the designed morphology confers to these devices an enhanced drug delivery capability with respect to monolithic unstructured supports. After incubation with BDNF, micropillared PCL devices progressively release the neurotrophin over 21 days in vitro. Moreover, the bioactivity of released BDNF is confirmed using primary neuronal cultures, where it mediates a consistent activation of BDNF signaling cascades, increased synaptic density, and neuronal survival. These results provide the proof-of-principle on the fabrication process of micropatterned PCL devices, which represent a promising therapeutic option to enhance neuronal regeneration after lesion and for neural tissue engineering and prosthetics.

Innovation in user-centered skills and performance improvement for sustainable complex service systems.

PubMed

Karwowski, Waldemar; Ahram, Tareq Z

2012-01-01

In order to leverage individual and organizational learning and to remain competitive in current turbulent markets it is important for employees, managers, planners and leaders to perform at high levels over time. Employee competence and skills are extremely important matters in view of the general shortage of talent and the mobility of employees with talent. Two factors emerged to have the greatest impact on the competitiveness of complex service systems: improving managerial and employee's knowledge attainment for skills, and improving the training and development of the workforce. This paper introduces the knowledge-based user-centered service design approach for sustainable skill and performance improvement in education, design and modeling of the next generation of complex service systems. The rest of the paper cover topics in human factors and sustainable business process modeling for the service industry, and illustrates the user-centered service system development cycle with the integration of systems engineering concepts in service systems. A roadmap for designing service systems of the future is discussed. The framework introduced in this paper is based on key user-centered design principles and systems engineering applications to support service competitiveness.

Confirmatory factor analysis of teaching and learning guiding principles instrument among teacher educators in higher education institutions

NASA Astrophysics Data System (ADS)

Masuwai, Azwani; Tajudin, Nor'ain Mohd; Saad, Noor Shah

2017-05-01

The purpose of this study is to develop and establish the validity and reliability of an instrument to generate teaching and learning guiding principles using Teaching and Learning Guiding Principles Instrument (TLGPI). Participants consisted of 171 Malaysian teacher educators. It is an essential instrument to reflect in generating the teaching and learning guiding principles in higher education level in Malaysia. Confirmatory Factor Analysis has validated all 19 items of TLGPI whereby all items indicated high reliability and internal consistency. A Confirmatory Factor Analysis also confirmed that a single factor model was used to generate teaching and learning guiding principles.

Extrapolation, uncertainty factors, and the precautionary principle.

PubMed

Steel, Daniel

2011-09-01

This essay examines the relationship between the precautionary principle and uncertainty factors used by toxicologists to estimate acceptable exposure levels for toxic chemicals from animal experiments. It shows that the adoption of uncertainty factors in the United States in the 1950s can be understood by reference to the precautionary principle, but not by cost-benefit analysis because of a lack of relevant quantitative data at that time. In addition, it argues that uncertainty factors continue to be relevant to efforts to implement the precautionary principle and that the precautionary principle should not be restricted to cases involving unquantifiable hazards. Copyright © 2011 Elsevier Ltd. All rights reserved.

Towards a theoretical clarification of biomimetics using conceptual tools from engineering design.

PubMed

Drack, M; Limpinsel, M; de Bruyn, G; Nebelsick, J H; Betz, O

2017-12-13

Many successful examples of biomimetic products are available, and most research efforts in this emerging field are directed towards the development of specific applications. The theoretical and conceptual underpinnings of the knowledge transfer between biologists, engineers and architects are, however, poorly investigated. The present article addresses this gap. We use a 'technomorphic' approach, i.e. the application of conceptual tools derived from engineering design, to better understand the processes operating during a typical biomimetic research project. This helps to elucidate the formal connections between functions, working principles and constructions (in a broad sense)-because the 'form-function-relationship' is a recurring issue in biology and engineering. The presented schema also serves as a conceptual framework that can be implemented for future biomimetic projects. The concepts of 'function' and 'working principle' are identified as the core elements in the biomimetic knowledge transfer towards applications. This schema not only facilitates the development of a common language in the emerging science of biomimetics, but also promotes the interdisciplinary dialogue among its subdisciplines.

Emerging engineering principles for yield improvement in microbial cell design.

PubMed

Comba, Santiago; Arabolaza, Ana; Gramajo, Hugo

2012-01-01

Metabolic Engineering has undertaken a rapid transformation in the last ten years making real progress towards the production of a wide range of molecules and fine chemicals using a designed cellular host. However, the maximization of product yields through pathway optimization is a constant and central challenge of this field. Traditional methods used to improve the production of target compounds from engineered biosynthetic pathways in non-native hosts include: codon usage optimization, elimination of the accumulation of toxic intermediates or byproducts, enhanced production of rate-limiting enzymes, selection of appropriate promoter and ribosome binding sites, application of directed evolution of enzymes, and chassis re-circuit. Overall, these approaches tend to be specific for each engineering project rather than a systematic practice based on a more generalizable strategy. In this mini-review, we highlight some novel and extensive approaches and tools intended to address the improvement of a target product formation, founded in sophisticated principles such as dynamic control, pathway genes modularization, and flux modeling.

Emerging engineering principles for yield improvement in microbial cell design

PubMed Central

Comba, Santiago; Arabolaza, Ana; Gramajo, Hugo

2012-01-01

Metabolic Engineering has undertaken a rapid transformation in the last ten years making real progress towards the production of a wide range of molecules and fine chemicals using a designed cellular host. However, the maximization of product yields through pathway optimization is a constant and central challenge of this field. Traditional methods used to improve the production of target compounds from engineered biosynthetic pathways in non-native hosts include: codon usage optimization, elimination of the accumulation of toxic intermediates or byproducts, enhanced production of rate-limiting enzymes, selection of appropriate promoter and ribosome binding sites, application of directed evolution of enzymes, and chassis re-circuit. Overall, these approaches tend to be specific for each engineering project rather than a systematic practice based on a more generalizable strategy. In this mini-review, we highlight some novel and extensive approaches and tools intended to address the improvement of a target product formation, founded in sophisticated principles such as dynamic control, pathway genes modularization, and flux modeling. PMID:24688676

Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.

PubMed

Barrett, David M; Grupp, Stephan A; June, Carl H

2015-08-01

The field of adoptive cell transfer (ACT) is currently comprised of chimeric Ag receptor (CAR)- and TCR-engineered T cells and has emerged from principles of basic immunology to paradigm-shifting clinical immunotherapy. ACT of T cells engineered to express artificial receptors that target cells of choice is an exciting new approach for cancer, and it holds equal promise for chronic infection and autoimmunity. Using principles of synthetic biology, advances in immunology, and genetic engineering have made it possible to generate human T cells that display desired specificities and enhanced functionalities. Clinical trials in patients with advanced B cell leukemias and lymphomas treated with CD19-specific CAR T cells have induced durable remissions in adults and children. The prospects for the widespread availability of engineered T cells have changed dramatically given the recent entry of the pharmaceutical industry to this arena. In this overview, we discuss some of the challenges and opportunities that face the field of ACT. Copyright © 2015 by The American Association of Immunologists, Inc.

Engineering a humanized bone organ model in mice to study bone metastases.

PubMed

Martine, Laure C; Holzapfel, Boris M; McGovern, Jacqui A; Wagner, Ferdinand; Quent, Verena M; Hesami, Parisa; Wunner, Felix M; Vaquette, Cedryck; De-Juan-Pardo, Elena M; Brown, Toby D; Nowlan, Bianca; Wu, Dan Jing; Hutmacher, Cosmo Orlando; Moi, Davide; Oussenko, Tatiana; Piccinini, Elia; Zandstra, Peter W; Mazzieri, Roberta; Lévesque, Jean-Pierre; Dalton, Paul D; Taubenberger, Anna V; Hutmacher, Dietmar W

2017-04-01

Current in vivo models for investigating human primary bone tumors and cancer metastasis to the bone rely on the injection of human cancer cells into the mouse skeleton. This approach does not mimic species-specific mechanisms occurring in human diseases and may preclude successful clinical translation. We have developed a protocol to engineer humanized bone within immunodeficient hosts, which can be adapted to study the interactions between human cancer cells and a humanized bone microenvironment in vivo. A researcher trained in the principles of tissue engineering will be able to execute the protocol and yield study results within 4-6 months. Additive biomanufactured scaffolds seeded and cultured with human bone-forming cells are implanted ectopically in combination with osteogenic factors into mice to generate a physiological bone 'organ', which is partially humanized. The model comprises human bone cells and secreted extracellular matrix (ECM); however, other components of the engineered tissue, such as the vasculature, are of murine origin. The model can be further humanized through the engraftment of human hematopoietic stem cells (HSCs) that can lead to human hematopoiesis within the murine host. The humanized organ bone model has been well characterized and validated and allows dissection of some of the mechanisms of the bone metastatic processes in prostate and breast cancer.

An exploration of the biomedical optics course construction of undergraduate biomedical engineering program in medical colleges

NASA Astrophysics Data System (ADS)

Guo, Shijun; Lyu, Jie; Zhang, Peiming

2017-08-01

In this paper, the teaching goals, teaching contents and teaching methods in biomedical optics course construction are discussed. From the dimension of teaching goals, students should master the principle of optical inspection on the human body, diagnosis and treatment of methodology and instruments, through the study of the theory and practice of this course, and can utilize biomedical optics methods to solve practical problems in the clinical medical engineering practice. From the dimension of teaching contents, based on the characteristics of biomedical engineering in medical colleges, the organic integration of engineering aspects, medical optical instruments, and biomedical aspects dispersed in human anatomy, human physiology, clinical medicine fundamental related to the biomedical optics is build. Noninvasive measurement of the human body composition and noninvasive optical imaging of the human body were taken as actual problems in biomedical optics fields. Typical medical applications such as eye optics and laser medicine were also integrated into the theory and practice teaching. From the dimension of teaching methods, referencing to organ-system based medical teaching mode, optical principle and instrument principle were taught by teachers from school of medical instruments, and the histological characteristics and clinical actual need in areas such as digestive diseases and urinary surgery were taught by teachers from school of basic medicine or clinical medicine of medical colleges. Furthermore, clinical application guidance would be provided by physician and surgeons in hospitals.

Recoding aminoacyl-tRNA synthetases for synthetic biology by rational protein-RNA engineering.

PubMed

Hadd, Andrew; Perona, John J

2014-12-19

We have taken a rational approach to redesigning the amino acid binding and aminoacyl-tRNA pairing specificities of bacterial glutaminyl-tRNA synthetase. The four-stage engineering incorporates generalizable design principles and improves the pairing efficiency of noncognate glutamate with tRNA(Gln) by over 10(5)-fold compared to the wild-type enzyme. Better optimized designs of the protein-RNA complex include substantial reengineering of the globular core region of the tRNA, demonstrating a role for specific tRNA nucleotides in specifying the identity of the genetically encoded amino acid. Principles emerging from this engineering effort open new prospects for combining rational and genetic selection approaches to design novel aminoacyl-tRNA synthetases that ligate noncanonical amino acids onto tRNAs. This will facilitate reconstruction of the cellular translation apparatus for applications in synthetic biology.

Materials for Liquid Propulsion Systems. Chapter 12

NASA Technical Reports Server (NTRS)

Halchak, John A.; Cannon, James L.; Brown, Corey

2016-01-01

Earth to orbit launch vehicles are propelled by rocket engines and motors, both liquid and solid. This chapter will discuss liquid engines. The heart of a launch vehicle is its engine. The remainder of the vehicle (with the notable exceptions of the payload and guidance system) is an aero structure to support the propellant tanks which provide the fuel and oxidizer to feed the engine or engines. The basic principle behind a rocket engine is straightforward. The engine is a means to convert potential thermochemical energy of one or more propellants into exhaust jet kinetic energy. Fuel and oxidizer are burned in a combustion chamber where they create hot gases under high pressure. These hot gases are allowed to expand through a nozzle. The molecules of hot gas are first constricted by the throat of the nozzle (de-Laval nozzle) which forces them to accelerate; then as the nozzle flares outwards, they expand and further accelerate. It is the mass of the combustion gases times their velocity, reacting against the walls of the combustion chamber and nozzle, which produce thrust according to Newton's third law: for every action there is an equal and opposite reaction. Solid rocket motors are cheaper to manufacture and offer good values for their cost. Liquid propellant engines offer higher performance, that is, they deliver greater thrust per unit weight of propellant burned. They also have a considerably higher thrust to weigh ratio. Since liquid rocket engines can be tested several times before flight, they have the capability to be more reliable, and their ability to shut down once started provides an extra margin of safety. Liquid propellant engines also can be designed with restart capability to provide orbital maneuvering capability. In some instances, liquid engines also can be designed to be reusable. On the solid side, hybrid solid motors also have been developed with the capability to stop and restart. Solid motors are covered in detail in chapter 11. Liquid rocket engine operational factors can be described in terms of extremes: temperatures ranging from that of liquid hydrogen (-423 F) to 6000 F hot gases; enormous thermal shock (7000 F/sec); large temperature differentials between contiguous components; reactive propellants; extreme acoustic environments; high rotational speeds for turbo machinery and extreme power densities. These factors place great demands on materials selection and each must be dealt with while maintaining an engine of the lightest possible weight. This chapter will describe the design considerations for the materials used in the various components of liquid rocket engines and provide examples of usage and experiences in each.

Systems Engineering and Integration as a Foundation for Mission Engineering

DTIC Science & Technology

2015-09-01

parallels the INCOSE definition to develop a system, it is important to note the focus on a complete life cycle balanced solution and the satisfaction of...unacceptable to relevant stakeholders. Principle 7 Managers should acknowledge the potential conflicts between (a) their own role as corporate...engineer in understanding the relationships between various needs and to identify similarities, differences, or redundancies. Another method for

Defense Acquisitions: Addressing Incentives is Key to Further Reform Efforts

DTIC Science & Technology

2014-04-30

championed sound management practices, such as realistic cost estimating, prototyping, and systems engineering . While some progress has been made...other reforms have championed sound management practices, such as realistic cost estimating, prototyping, and systems engineering . DOD’s declining...principles from disciplines such as systems engineering , as well as lessons learned and past reforms. The body of work we have done on benchmarking

Welding As Science: Applying Basic Engineering Principles to the Discipline

NASA Technical Reports Server (NTRS)

Nunes, A. C., Jr.

2010-01-01

This Technical Memorandum provides sample problems illustrating ways in which basic engineering science has been applied to the discipline of welding. Perhaps inferences may be drawn regarding optimal approaches to particular welding problems, as well as for the optimal education for welding engineers. Perhaps also some readers may be attracted to the science(s) of welding and may make worthwhile contributions to the discipline.

Astronautics

NASA Technical Reports Server (NTRS)

1977-01-01

Principles of rocket engineering, flight dynamics, and trajectories are discussed in this summary of Soviet rocket development and technology. Topics include rocket engine design, propellants, propulsive efficiency, and capabilities required for orbital launch. The design of the RD 107, 108, 119, and 214 rocket engines and their uses in various satellite launches are described. NASA's Saturn 5 and Atlas Agena launch vehicles are used to illustrate the requirements of multistage rockets.

Strengthening the Link between Theory and Practice in Teaching Design Engineering: An Empirical Study on a New Approach

ERIC Educational Resources Information Center

Tempelman, E.; Pilot, A.

2011-01-01

In 2007, the Faculty of Industrial Design Engineering of the Delft University of Technology introduced a new bachelor program. Based on theories of learning and instruction three design principles were used to develop an approach that aims to make it easier for students to bridge the gap between theoretical design engineering courses and practical…

Assessment Engineering Task Model Maps, Task Models and Templates as a New Way to Develop and Implement Test Specifications

ERIC Educational Resources Information Center

Luecht, Richard M.

2013-01-01

Assessment engineering is a new way to design and implement scalable, sustainable and ideally lower-cost solutions to the complexities of designing and developing tests. It represents a merger of sorts between cognitive task modeling and engineering design principles--a merger that requires some new thinking about the nature of score scales, item…

Two stroke homogenous charge compression ignition engine with pulsed air supplier

DOEpatents

Clarke, John M.

2003-08-05

A two stroke homogenous charge compression ignition engine includes a volume pulsed air supplier, such as a piston driven pump, for efficient scavenging. The usage of a homogenous charge tends to decrease emissions. The use of a volume pulsed air supplier in conjunction with conventional poppet type intake and exhaust valves results in a relatively efficient scavenging mode for the engine. The engine preferably includes features that permit valving event timing, air pulse event timing and injection event timing to be varied relative to engine crankshaft angle. The principle use of the invention lies in improving diesel engines.

Engineering Elegant Systems: Postulates, Principles, and Hypotheses of Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.

2018-01-01

Definition: System Engineering is the engineering discipline which integrates the system functions, system environment, and the engineering disciplines necessary to produce and/or operate an elegant system; Elegant System - A system that is robust in application, fully meeting specified and adumbrated intent, is well structured, and is graceful in operation. Primary Focus: System Design and Integration: Identify system couplings and interactions; Identify system uncertainties and sensitivities; Identify emergent properties; Manage the effectiveness of the system. Engineering Discipline Integration: Manage flow of information for system development and/or operations; Maintain system activities within budget and schedule. Supporting Activities: Process application and execution.

Quality engineering as a profession.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolb, Rachel R.; Hoover, Marcey L.

Over the course of time, the profession of quality engineering has witnessed significant change, from its original emphasis on quality control and inspection to a more contemporary focus on upholding quality processes throughout the organization and its product realization activities. This paper describes the profession of quality engineering, exploring how todays quality engineers and quality professionals are certified individuals committed to upholding quality processes and principles while working with different dimensions of product development. It also discusses the future of the quality engineering profession and the future of the quality movement as a whole.

Symposium on Aviation Psychology, 1st, Ohio State University, Columbus, OH, April 21, 22, 1981, Proceedings

NASA Technical Reports Server (NTRS)

1981-01-01

The impact of modern technology on the role, responsibility, authority, and performance of human operators in modern aircraft and ATC systems was examined in terms of principles defined by Paul Fitts. Research into human factors in aircraft operations and the use of human factors engineering for aircraft safety improvements were discussed, and features of the man-machine interface in computerized cockpit warning systems are examined. The design and operational features of computerized avionics displays and HUDs are described, along with results of investigations into pilot decision-making behavior, aircrew procedural compliance, and aircrew judgment training programs. Experiments in vision and visual perception are detailed, as are behavioral studies of crew workload, coordination, and complement. The effectiveness of pilot selection, screening, and training techniques are assessed, as are methods for evaluating pilot performance.

Evolutionary mechanics: new engineering principles for the emergence of flexibility in a dynamic and uncertain world.

PubMed

Whitacre, James M; Rohlfshagen, Philipp; Bender, Axel; Yao, Xin

2012-09-01

Engineered systems are designed to deftly operate under predetermined conditions yet are notoriously fragile when unexpected perturbations arise. In contrast, biological systems operate in a highly flexible manner; learn quickly adequate responses to novel conditions, and evolve new routines and traits to remain competitive under persistent environmental change. A recent theory on the origins of biological flexibility has proposed that degeneracy-the existence of multi-functional components with partially overlapping functions-is a primary determinant of the robustness and adaptability found in evolved systems. While degeneracy's contribution to biological flexibility is well documented, there has been little investigation of degeneracy design principles for achieving flexibility in systems engineering. Actually, the conditions that can lead to degeneracy are routinely eliminated in engineering design. With the planning of transportation vehicle fleets taken as a case study, this article reports evidence that degeneracy improves the robustness and adaptability of a simulated fleet towards unpredicted changes in task requirements without incurring costs to fleet efficiency. We find that degeneracy supports faster rates of design adaptation and ultimately leads to better fleet designs. In investigating the limitations of degeneracy as a design principle, we consider decision-making difficulties that arise from degeneracy's influence on fleet complexity. While global decision-making becomes more challenging, we also find degeneracy accommodates rapid distributed decision-making leading to (near-optimal) robust system performance. Given the range of conditions where favorable short-term and long-term performance outcomes are observed, we propose that degeneracy may fundamentally alter the propensity for adaptation and is useful within different engineering and planning contexts.

Presenting Science to the Public. The Professional Writing Series.

ERIC Educational Resources Information Center

Gastel, Barbara

This book introduces scientists, health professionals, and engineers to principles of communicating with the public and to practical aspects of dealing with the press. Part I focuses on the advantages, principles, and problems of communicating with the public. Part II discusses the nature of science reporting and offers advice for presenting…

Design Principles for the Atomic and Electronic Structure of Halide Perovskite Photovoltaic Materials: Insights from Computation.

PubMed

Berger, Robert F

2018-02-09

In the current decade, perovskite solar cell research has emerged as a remarkably active, promising, and rapidly developing field. Alongside breakthroughs in synthesis and device engineering, halide perovskite photovoltaic materials have been the subject of predictive and explanatory computational work. In this Minireview, we focus on a subset of this computation: density functional theory (DFT)-based work highlighting the ways in which the electronic structure and band gap of this class of materials can be tuned via changes in atomic structure. We distill this body of computational literature into a set of underlying design principles for the band gap engineering of these materials, and rationalize these principles from the viewpoint of band-edge orbital character. We hope that this perspective provides guidance and insight toward the rational design and continued improvement of perovskite photovoltaics. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Green tribology: principles, research areas and challenges.

PubMed

Nosonovsky, Michael; Bhushan, Bharat

2010-10-28

In this introductory paper for the Theme Issue on green tribology, we discuss the concept of green tribology and its relation to other areas of tribology as well as other 'green' disciplines, namely, green engineering and green chemistry. We formulate the 12 principles of green tribology: the minimization of (i) friction and (ii) wear, (iii) the reduction or complete elimination of lubrication, including self-lubrication, (iv) natural and (v) biodegradable lubrication, (vi) using sustainable chemistry and engineering principles, (vii) biomimetic approaches, (viii) surface texturing, (ix) environmental implications of coatings, (x) real-time monitoring, (xi) design for degradation, and (xii) sustainable energy applications. We further define three areas of green tribology: (i) biomimetics for tribological applications, (ii) environment-friendly lubrication, and (iii) the tribology of renewable-energy application. The integration of these areas remains a primary challenge for this novel area of research. We also discuss the challenges of green tribology and future directions of research.

ETHICS AND JUSTICE IN ENVIRONMENTAL SCIENCE AND ENGINEERING

EPA Science Inventory

Science and engineering are built on trust. C.P. Snow's famous quote, "the only ethical principle which has made science possible is that the truth shall be told all the time" underscores the importance of honesty in science. Environmental scientists must do work that is useful...

Physics for First-Graders.

ERIC Educational Resources Information Center

Hagerott, Steven G.

1997-01-01

A Lockheed flight controls engineer describes how, as an undergraduate, he taught first graders basic lessons in physics and engineering by using slides, monkey bars, and other playground equipment to demonstrate principles like gravity, friction, force, and inertia. The children learned more about lift and gravity by constructing and flying paper…

Using Green Chemistry and Engineering Principles to Design, Assess, and Retrofit Chemical Processes for Sustainability

EPA Science Inventory

The concepts of green chemistry and engineering (GC&E) have been promoted as an effective qualitative framework for developing more sustainable chemical syntheses, processes, and material management techniques. This has been demonstrated by many theoretical and practical cases. I...

How Much Safety Do We Need in ChE Education?

ERIC Educational Resources Information Center

Mewis, Jan

1984-01-01

Discusses aims, objectives, and content of a safety course for chemical engineering students. Course emphasizes awareness of hazards, basic concepts and principles of safety engineering, and the ability to recognize, assess, and remedy specific risks occurring in chemical plants. Course implementation is also discussed. (JN)

Picasso, Car Classics, and the Engineers.

ERIC Educational Resources Information Center

Wosk, Julie H.

1982-01-01

Describes a college course which introduces engineering and business students to abstract art. Students study the relationships between abstract styles in painting and abstract styles in twentieth-century architecture and industrial design. The relevance of abstract design principles is shown by referring students to "Car and Driver"…

Engineering directorate technical facilities catalog

NASA Technical Reports Server (NTRS)

Maloy, Joseph E.

1993-01-01

The Engineering Directorate Technical Facilities Catalog is designed to provide an overview of the technical facilities available within the Engineering Directorate at the National Aeronautics and Space Administration (NASA), Lyndon B. Johnson Space Center (JSC) in Houston, Texas. The combined capabilities of these engineering facilities are essential elements of overall JSC capabilities required to manage and perform major NASA engineering programs. The facilities are grouped in the text by chapter according to the JSC division responsible for operation of the facility. This catalog updates the facility descriptions for the JSC Engineering Directorate Technical Facilities Catalog, JSC 19295 (August 1989), and supersedes the Engineering Directorate, Principle test and Development Facilities, JSC, 19962 (November 1984).

LEADER - An integrated engine behavior and design analyses based real-time fault diagnostic expert system for Space Shuttle Main Engine (SSME)

NASA Technical Reports Server (NTRS)

Gupta, U. K.; Ali, M.

1989-01-01

The LEADER expert system has been developed for automatic learning tasks encompassing real-time detection, identification, verification, and correction of anomalous propulsion system operations, using a set of sensors to monitor engine component performance to ascertain anomalies in engine dynamics and behavior. Two diagnostic approaches are embodied in LEADER's architecture: (1) learning and identifying engine behavior patterns to generate novel hypotheses about possible abnormalities, and (2) the direction of engine sensor data processing to perform resoning based on engine design and functional knowledge, as well as the principles of the relevant mechanics and physics.

A review of selected pumping systems in nature and engineering--potential biomimetic concepts for improving displacement pumps and pulsation damping.

PubMed

Bach, D; Schmich, F; Masselter, T; Speck, T

2015-09-03

The active transport of fluids by pumps plays an essential role in engineering and biology. Due to increasing energy costs and environmental issues, topics like noise reduction, increase of efficiency and enhanced robustness are of high importance in the development of pumps in engineering. The study compares pumps in biology and engineering and assesses biomimetic potentials for improving man-made pumping systems. To this aim, examples of common challenges, applications and current biomimetic research for state-of-the art pumps are presented. The biomimetic research is helped by the similar configuration of many positive displacement pumping systems in biology and engineering. In contrast, the configuration and underlying pumping principles for fluid dynamic pumps (FDPs) differ to a greater extent in biology and engineering. However, progress has been made for positive displacement as well as for FDPs by developing biomimetic devices with artificial muscles and cilia that improve energetic efficiency and fail-safe operation or reduce noise. The circulatory system of vertebrates holds a high biomimetic potential for the damping of pressure pulsations, a common challenge in engineering. Damping of blood pressure pulsation results from a nonlinear viscoelastic behavior of the artery walls which represent a complex composite material. The transfer of the underlying functional principle could lead to an improvement of existing technical solutions and be used to develop novel biomimetic damping solutions. To enhance efficiency or thrust of man-made fluid transportation systems, research on jet propulsion in biology has shown that a pulsed jet can be tuned to either maximize thrust or efficiency. The underlying principle has already been transferred into biomimetic applications in open channel water systems. Overall there is a high potential to learn from nature in order to improve pumping systems for challenges like the reduction of pressure pulsations, increase of jet propulsion efficiency or the reduction of wear.

Introduction to Color Imaging Science

NASA Astrophysics Data System (ADS)

Lee, Hsien-Che

2005-04-01

Color imaging technology has become almost ubiquitous in modern life in the form of monitors, liquid crystal screens, color printers, scanners, and digital cameras. This book is a comprehensive guide to the scientific and engineering principles of color imaging. It covers the physics of light and color, how the eye and physical devices capture color images, how color is measured and calibrated, and how images are processed. It stresses physical principles and includes a wealth of real-world examples. The book will be of value to scientists and engineers in the color imaging industry and, with homework problems, can also be used as a text for graduate courses on color imaging.

Integrating biological redesign: where synthetic biology came from and where it needs to go.

PubMed

Way, Jeffrey C; Collins, James J; Keasling, Jay D; Silver, Pamela A

2014-03-27

Synthetic biology seeks to extend approaches from engineering and computation to redesign of biology, with goals such as generating new chemicals, improving human health, and addressing environmental issues. Early on, several guiding principles of synthetic biology were articulated, including design according to specification, separation of design from fabrication, use of standardized biological parts and organisms, and abstraction. We review the utility of these principles over the past decade in light of the field's accomplishments in building complex systems based on microbial transcription and metabolism and describe the progress in mammalian cell engineering. Copyright © 2014 Elsevier Inc. All rights reserved.

Embryo mechanics: balancing force production with elastic resistance during morphogenesis.

PubMed

Davidson, Lance A

2011-01-01

Morphogenesis requires the spatial and temporal control of embryo mechanics, including force production and mechanical resistance to those forces, to coordinate tissue deformation and large-scale movements. Thus, biomechanical processes play a key role in directly shaping the embryo. Additional roles for embryo mechanics during development may include the patterning of positional information and to provide feedback to ensure the success of morphogenetic movements in shaping the larval body and organs. To understand the multiple roles of mechanics during development requires familiarity with engineering principles of the mechanics of structures, the viscoelastic properties of biomaterials, and the integration of force and stress within embryonic structures as morphogenesis progresses. In this chapter, we review the basic engineering principles of biomechanics as they relate to morphogenesis, introduce methods for quantifying embryo mechanics and the limitations of these methods, and outline a formalism for investigating the role of embryo mechanics in birth defects. We encourage the nascent field of embryo mechanics to adopt standard engineering terms and test methods so that studies of diverse organisms can be compared and universal biomechanical principles can be revealed. Copyright © 2011 Elsevier Inc. All rights reserved.

Bioinspired Principles for Large-Scale Networked Sensor Systems: An Overview

PubMed Central

Jacobsen, Rune Hylsberg; Zhang, Qi; Toftegaard, Thomas Skjødeberg

2011-01-01

Biology has often been used as a source of inspiration in computer science and engineering. Bioinspired principles have found their way into network node design and research due to the appealing analogies between biological systems and large networks of small sensors. This paper provides an overview of bioinspired principles and methods such as swarm intelligence, natural time synchronization, artificial immune system and intercellular information exchange applicable for sensor network design. Bioinspired principles and methods are discussed in the context of routing, clustering, time synchronization, optimal node deployment, localization and security and privacy. PMID:22163841

Database Search Engines: Paradigms, Challenges and Solutions.

PubMed

Verheggen, Kenneth; Martens, Lennart; Berven, Frode S; Barsnes, Harald; Vaudel, Marc

2016-01-01

The first step in identifying proteins from mass spectrometry based shotgun proteomics data is to infer peptides from tandem mass spectra, a task generally achieved using database search engines. In this chapter, the basic principles of database search engines are introduced with a focus on open source software, and the use of database search engines is demonstrated using the freely available SearchGUI interface. This chapter also discusses how to tackle general issues related to sequence database searching and shows how to minimize their impact.

High Pressure Regenerative Turbine Engine: 21st Century Propulsion

NASA Technical Reports Server (NTRS)

Lear, W. E.; Laganelli, A. L.; Senick, Paul (Technical Monitor)

2001-01-01

A novel semi-closed cycle gas turbine engine was demonstrated and was found to meet the program goals. The proof-of-principle test of the High Pressure Regenerative Turbine Engine produced data that agreed well with models, enabling more confidence in designing future prototypes based on this concept. Emission levels were significantly reduced as predicted as a natural attribute of this power cycle. Engine testing over a portion of the operating range allowed verification of predicted power increases compared to the baseline.

The Fundamental Principles of High-speed Semi-diesel Engines. Part I: a General Discussion of the Subject of Fuel Injection in Diesel Engines and Detailed Descriptions of Many Types of Injection Nozzles

NASA Technical Reports Server (NTRS)

Buchner,

1926-01-01

Three questions relating to the technical progress in the utilization of heavy oils are discussed. The first question considers solid injection in high-speed automobile engines, the second concerns the development of the hot-bulb engine, and the third question relates to the need for a more thorough investigation of the processes on which the formatation of combustible, rapidly-burning mixtures depend.

Engineering Ecosystems and Synthetic Ecologies#

PubMed Central

Mee, Michael T; Wang, Harris H

2012-01-01

Microbial ecosystems play an important role in nature. Engineering these systems for industrial, medical, or biotechnological purposes are important pursuits for synthetic biologists and biological engineers moving forward. Here, we provide a review of recent progress in engineering natural and synthetic microbial ecosystems. We highlight important forward engineering design principles, theoretical and quantitative models, new experimental and manipulation tools, and possible applications of microbial ecosystem engineering. We argue that simply engineering individual microbes will lead to fragile homogenous populations that are difficult to sustain, especially in highly heterogeneous and unpredictable environments. Instead, engineered microbial ecosystems are likely to be more robust and able to achieve complex tasks at the spatial and temporal resolution needed for truly programmable biology. PMID:22722235

26 CFR 1.43-2 - Qualified enhanced oil recovery project.

Code of Federal Regulations, 2010 CFR

2010-04-01

... not obtained, to obtain a chemical or physical reaction (other than pressure) between the oil and the... following requirements— (1) The project involves the application (in accordance with sound engineering... engineering principles and whether the change in method will result in more than an insignificant increase in...

A Design-Based Engineering Graphics Course for First-Year Students.

ERIC Educational Resources Information Center

Smith, Shana Shiang-Fong

2003-01-01

Describes the first-year Introduction to Design course at Iowa State University which incorporates design for manufacturing and concurrent engineering principles into the curriculum. Autodesk Inventor was used as the primary CAD tool for parametric solid modeling. Test results show that student spatial visualization skills were dramatically…

Bioinspired engineering of exploration systems for NASA and DoD: from bees to BEES

NASA Technical Reports Server (NTRS)

Thakoor, S.; Zornetzer, S.; Hine, B.; Chahl, J.; Werblin, F.; Srinivasan, M. V.; Young, L.

2003-01-01

The intent of Bio-inspired Engineering of Exploration Systems (BEES) is to distill the principles found in successful, nature-tested mechanisms of specific crucial functions that are hard to accomplish by conventional methods, but accomplished rather deftly in nature by biological organisms.

Control Engineering, System Theory and Mathematics: The Teacher's Challenge

ERIC Educational Resources Information Center

Zenger, K.

2007-01-01

The principles, difficulties and challenges in control education are discussed and compared to the similar problems in the teaching of mathematics and systems science in general. The difficulties of today's students to appreciate the classical teaching of engineering disciplines, which are based on rigorous and scientifically sound grounds, are…

You and Technology, A High School Case Study Text.

ERIC Educational Resources Information Center

Damaskos, Nickander J., Ed.; Smyth, Michael P., Ed.

This second draft of a manuscript for a high school engineering and technology course uses case studies as its format. The principles associated with various engineering problems are presented along with their effects on daily life. Topics include the computer, the automotive power system, satellite communications, the petroleum industry, water…

The Impact of New Learning Environments in an Engineering Design Course

ERIC Educational Resources Information Center

Dinsmore, Daniel L.; Alexander, Patricia A.; Loughlin, Sandra M.

2008-01-01

In this study, we investigated the effects of students' participation in a collaborative, project-based engineering design course on their domain knowledge, interests, and strategic processing. Participants were 70 college seniors working in teams on a design project of their choosing. Their declarative, procedural, and principled knowledge, along…

40 CFR 63.115 - Process vent provisions-methods and procedures for process vent group determination.

Code of Federal Regulations, 2011 CFR

2011-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage Vessels, Transfer... (d)(3) of this section. (1) Engineering assessment may be used to determine vent stream flow rate...

40 CFR 63.115 - Process vent provisions-methods and procedures for process vent group determination.

Code of Federal Regulations, 2013 CFR

2013-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage Vessels, Transfer... (d)(3) of this section. (1) Engineering assessment may be used to determine vent stream flow rate...

40 CFR 63.115 - Process vent provisions-methods and procedures for process vent group determination.

Code of Federal Regulations, 2014 CFR

2014-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage Vessels, Transfer... (d)(3) of this section. (1) Engineering assessment may be used to determine vent stream flow rate...

40 CFR 63.115 - Process vent provisions-methods and procedures for process vent group determination.

Code of Federal Regulations, 2012 CFR

2012-07-01

... accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or... From the Synthetic Organic Chemical Manufacturing Industry for Process Vents, Storage Vessels, Transfer... (d)(3) of this section. (1) Engineering assessment may be used to determine vent stream flow rate...

General Mechanical Repair. Minor Automotive Maintenance. Volume 1. Teacher's Guide.

ERIC Educational Resources Information Center

East Texas State Univ., Commerce. Occupational Curriculum Lab.

Fourteen units on minor automotive maintenance are presented in this teacher's guide. The units are the following: introduction to minor automotive maintenance, shop safety, engine principles, fuel system operation and repair, electrical system, ignition system, lubrication system, engine cooling system, exhaust system, wheel bearings and tires,…

Some heat engine cycles in which liquids can work.

PubMed

Allen, P C; Paulson, D N; Wheatley, J C

1981-01-01

Liquids can work in heat engine cycles that employ regeneration. Four such cycles are discussed: Stirling, Malone, Stirling-Malone, and Brayton. Both regeneration and the role of the second thermodynamic medium are treated, and the principles are verified by quantitative measurements with propylene in a Stirling-Malone cycle.

Some heat engine cycles in which liquids can work

PubMed Central

Allen, P. C.; Paulson, D. N.; Wheatley, J. C.

1981-01-01

Liquids can work in heat engine cycles that employ regeneration. Four such cycles are discussed: Stirling, Malone, Stirling-Malone, and Brayton. Both regeneration and the role of the second thermodynamic medium are treated, and the principles are verified by quantitative measurements with propylene in a Stirling-Malone cycle. PMID:16592952

Imprinting Community College Computer Science Education with Software Engineering Principles

ERIC Educational Resources Information Center

Hundley, Jacqueline Holliday

2012-01-01

Although the two-year curriculum guide includes coverage of all eight software engineering core topics, the computer science courses taught in Alabama community colleges limit student exposure to the programming, or coding, phase of the software development lifecycle and offer little experience in requirements analysis, design, testing, and…

Impact Assessment of Problem-Based Learning in an Engineering Science Course

ERIC Educational Resources Information Center

Nasr, Karim J.; Ramadan, Bassem H.

2008-01-01

This paper presents the development and implementation of Problem-Based Learning (PBL) in an engineering thermodynamics course at Kettering University. In this project, the thermodynamics course was restructured as modules presenting practical applications first, whereas principles were introduced just-in-time and as encountered. Theoretical…

The systems engineering overview and process (from the Systems Engineering Management Guide, 1990)

NASA Technical Reports Server (NTRS)

1993-01-01

The past several decades have seen the rise of large, highly interactive systems that are on the forward edge of technology. As a result of this growth and the increased usage of digital systems (computers and software), the concept of systems engineering has gained increasing attention. Some of this attention is no doubt due to large program failures which possibly could have been avoided, or at least mitigated, through the use of systems engineering principles. The complexity of modern day weapon systems requires conscious application of systems engineering concepts to ensure producible, operable and supportable systems that satisfy mission requirements. Although many authors have traced the roots of systems engineering to earlier dates, the initial formalization of the systems engineering process for military development began to surface in the mid-1950s on the ballistic missile programs. These early ballistic missile development programs marked the emergence of engineering discipline 'specialists' which has since continued to grow. Each of these specialties not only has a need to take data from the overall development process, but also to supply data, in the form of requirements and analysis results, to the process. A number of technical instructions, military standards and specifications, and manuals were developed as a result of these development programs. In particular, MILSTD-499 was issued in 1969 to assist both government and contractor personnel in defining the systems engineering effort in support of defense acquisition programs. This standard was updated to MIL-STD499A in 1974, and formed the foundation for current application of systems engineering principles to military development programs.

The systems engineering overview and process (from the Systems Engineering Management Guide, 1990)

NASA Astrophysics Data System (ADS)

The past several decades have seen the rise of large, highly interactive systems that are on the forward edge of technology. As a result of this growth and the increased usage of digital systems (computers and software), the concept of systems engineering has gained increasing attention. Some of this attention is no doubt due to large program failures which possibly could have been avoided, or at least mitigated, through the use of systems engineering principles. The complexity of modern day weapon systems requires conscious application of systems engineering concepts to ensure producible, operable and supportable systems that satisfy mission requirements. Although many authors have traced the roots of systems engineering to earlier dates, the initial formalization of the systems engineering process for military development began to surface in the mid-1950s on the ballistic missile programs. These early ballistic missile development programs marked the emergence of engineering discipline 'specialists' which has since continued to grow. Each of these specialties not only has a need to take data from the overall development process, but also to supply data, in the form of requirements and analysis results, to the process. A number of technical instructions, military standards and specifications, and manuals were developed as a result of these development programs. In particular, MILSTD-499 was issued in 1969 to assist both government and contractor personnel in defining the systems engineering effort in support of defense acquisition programs. This standard was updated to MIL-STD499A in 1974, and formed the foundation for current application of systems engineering principles to military development programs.

Launch vehicle systems design analysis

NASA Technical Reports Server (NTRS)

Ryan, Robert; Verderaime, V.

1993-01-01

Current launch vehicle design emphasis is on low life-cycle cost. This paper applies total quality management (TQM) principles to a conventional systems design analysis process to provide low-cost, high-reliability designs. Suggested TQM techniques include Steward's systems information flow matrix method, quality leverage principle, quality through robustness and function deployment, Pareto's principle, Pugh's selection and enhancement criteria, and other design process procedures. TQM quality performance at least-cost can be realized through competent concurrent engineering teams and brilliance of their technical leadership.

Modified Universal Design Survey: Enhancing Operability of Launch Vehicle Ground Crew Worksites

NASA Technical Reports Server (NTRS)

Blume, Jennifer L.

2010-01-01

Operability is a driving requirement for next generation space launch vehicles. Launch site ground operations include numerous operator tasks to prepare the vehicle for launch or to perform preflight maintenance. Ensuring that components requiring operator interaction at the launch site are designed for optimal human use is a high priority for operability. To promote operability, a Design Quality Evaluation Survey based on Universal Design framework was developed to support Human Factors Engineering (HFE) evaluation for NASA s launch vehicles. Universal Design per se is not a priority for launch vehicle processing however; applying principles of Universal Design will increase the probability of an error free and efficient design which promotes operability. The Design Quality Evaluation Survey incorporates and tailors the seven Universal Design Principles and adds new measures for Safety and Efficiency. Adapting an approach proven to measure Universal Design Performance in Product, each principle is associated with multiple performance measures which are rated with the degree to which the statement is true. The Design Quality Evaluation Survey was employed for several launch vehicle ground processing worksite analyses. The tool was found to be most useful for comparative judgments as opposed to an assessment of a single design option. It provided a useful piece of additional data when assessing possible operator interfaces or worksites for operability.

Interface design and human factors considerations for model-based tight glycemic control in critical care.

PubMed

Ward, Logan; Steel, James; Le Compte, Aaron; Evans, Alicia; Tan, Chia-Siong; Penning, Sophie; Shaw, Geoffrey M; Desaive, Thomas; Chase, J Geoffrey

2012-01-01

Tight glycemic control (TGC) has shown benefits but has been difficult to implement. Model-based methods and computerized protocols offer the opportunity to improve TGC quality and compliance. This research presents an interface design to maximize compliance, minimize real and perceived clinical effort, and minimize error based on simple human factors and end user input. The graphical user interface (GUI) design is presented by construction based on a series of simple, short design criteria based on fundamental human factors engineering and includes the use of user feedback and focus groups comprising nursing staff at Christchurch Hospital. The overall design maximizes ease of use and minimizes (unnecessary) interaction and use. It is coupled to a protocol that allows nurse staff to select measurement intervals and thus self-manage workload. The overall GUI design is presented and requires only one data entry point per intervention cycle. The design and main interface are heavily focused on the nurse end users who are the predominant users, while additional detailed and longitudinal data, which are of interest to doctors guiding overall patient care, are available via tabs. This dichotomy of needs and interests based on the end user's immediate focus and goals shows how interfaces must adapt to offer different information to multiple types of users. The interface is designed to minimize real and perceived clinical effort, and ongoing pilot trials have reported high levels of acceptance. The overall design principles, approach, and testing methods are based on fundamental human factors principles designed to reduce user effort and error and are readily generalizable. © 2012 Diabetes Technology Society.

Interface Design and Human Factors Considerations for Model-Based Tight Glycemic Control in Critical Care

PubMed Central

Ward, Logan; Steel, James; Le Compte, Aaron; Evans, Alicia; Tan, Chia-Siong; Penning, Sophie; Shaw, Geoffrey M; Desaive, Thomas; Chase, J Geoffrey

2012-01-01

Introduction Tight glycemic control (TGC) has shown benefits but has been difficult to implement. Model-based methods and computerized protocols offer the opportunity to improve TGC quality and compliance. This research presents an interface design to maximize compliance, minimize real and perceived clinical effort, and minimize error based on simple human factors and end user input. Method The graphical user interface (GUI) design is presented by construction based on a series of simple, short design criteria based on fundamental human factors engineering and includes the use of user feedback and focus groups comprising nursing staff at Christchurch Hospital. The overall design maximizes ease of use and minimizes (unnecessary) interaction and use. It is coupled to a protocol that allows nurse staff to select measurement intervals and thus self-manage workload. Results The overall GUI design is presented and requires only one data entry point per intervention cycle. The design and main interface are heavily focused on the nurse end users who are the predominant users, while additional detailed and longitudinal data, which are of interest to doctors guiding overall patient care, are available via tabs. This dichotomy of needs and interests based on the end user's immediate focus and goals shows how interfaces must adapt to offer different information to multiple types of users. Conclusions The interface is designed to minimize real and perceived clinical effort, and ongoing pilot trials have reported high levels of acceptance. The overall design principles, approach, and testing methods are based on fundamental human factors principles designed to reduce user effort and error and are readily generalizable. PMID:22401330

Fundamentals of the Control of Gas-Turbine Power Plants for Aircraft. Part III Control of Jet Engines. Part 3; Control of Jet Engines

NASA Technical Reports Server (NTRS)

Kuehl, H.

1947-01-01

The basic principles of the control of TL ongincs are developed on .the basis of a quantitative investigation of the behavior of these behavior under various operating conditions with particular consideration of the simplifications pormissible in each case. Various possible means of control of jet engines are suggested and are illustrated by schematic designs.

Defense Acquisitions: Where Should Reform Aim Next?

DTIC Science & Technology

2013-10-29

realistic cost estimating, prototyping, and systems engineering . Too often, GAO reports on the same kinds of problems today that it did over 20... engineering . DOD’s declining budgets and the impact of sequestration have lent additional impetus to reduce the costs of weapons. While some progress has been...3 The sequence of events that comprise the process defined in policy reflects principles from disciplines such as systems engineering , as well as

Principles of Rapid Acquisition and Systems Engineering

DTIC Science & Technology

2012-06-14

Systems Engineering Research Council ( SERC ) research team interviewed over 30 organizations from across the DoD which focus on less traditional...enthusiasm • Lt Col John Elshaw, for his guidance on our statistical analysis • Our sponsors, the SERC , SAF/AQR, and the AF Center for Systems...experienced staff of 20 – 50 people” (Defense Science Board, 2011) Research Focus The Systems Engineering Research Center ( SERC ) has been charged with

Systems Engineering Case Studies: Synopsis of the Learning Principles

DTIC Science & Technology

2010-05-17

Engineering Case Study HST refers to the Hubble Space Telescope Systems Engineering Case Study TBMCS refers to the Theater Battle Management Core System...going to orbit undetected in spite of substantial evidence that could have been used to prevent this occurrence. TBMCS /1 Requirements Definition...baseline was volatile up to system acceptance, which took place after TBMCS passed operational test and evaluation. TBMCS /2 System Architecture The

Introduction to bioengineering: melding of engineering and biological sciences.

PubMed

Shoureshi, Rahmat A

2005-04-01

Engineering has traditionally focused on the external extensions of organisms, such as transportation systems, high-rise buildings, and entertainment systems. In contrast, bioengineering is concerned with inward processes of biologic organisms. Utilization of engineering principles and techniques in the analysis and solution of problems in medicine and biology is the basis for bioengineering. This article discusses subspecialties in bioengineering and presents examples of projects in this discipline.

Engineering the System and Technical Integration

NASA Technical Reports Server (NTRS)

Blair, J. C.; Ryan, R. S.; Schutzenhofer, L. A.

2011-01-01

Approximately 80% of the problems encountered in aerospace systems have been due to a breakdown in technical integration and/or systems engineering. One of the major challenges we face in designing, building, and operating space systems is: how is adequate integration achieved for the systems various functions, parts, and infrastructure? This Contractor Report (CR) deals with part of the problem of how we engineer the total system in order to achieve the best balanced design. We will discuss a key aspect of this question - the principle of Technical Integration and its components, along with management and decision making. The CR will first provide an introduction with a discussion of the Challenges in Space System Design and meeting the challenges. Next is an overview of Engineering the System including Technical Integration. Engineering the System is expanded to include key aspects of the Design Process, Lifecycle Considerations, etc. The basic information and figures used in this CR were presented in a NASA training program for Program and Project Managers Development (PPMD) in classes at Georgia Tech and at Marshall Space Flight Center (MSFC). Many of the principles and illustrations are extracted from the courses we teach for MSFC.

Adaptation of Combustion Principles to Aircraft Propulsion. Volume I; Basic Considerations in the Combustion of Hydrocarbon Fuels with Air

NASA Technical Reports Server (NTRS)

Barnett, Henry C (Editor); Hibbard, Robert R (Editor)

1955-01-01

The report summarizes source material on combustion for flight-propulsion engineers. First, several chapters review fundamental processes such as fuel-air mixture preparation, gas flow and mixing, flammability and ignition, flame propagation in both homogenous and heterogenous media, flame stabilization, combustion oscillations, and smoke and carbon formation. The practical significance and the relation of these processes to theory are presented. A second series of chapters describes the observed performance and design problems of engine combustors of the principal types. An attempt is made to interpret performance in terms of the fundamental processes and theories previously reviewed. Third, the design of high-speed combustion systems is discussed. Combustor design principles that can be established from basic considerations and from experience with actual combustors are described. Finally, future requirements for aircraft engine combustion systems are examined.

Is synthetic biology mechanical biology?

PubMed

Holm, Sune

2015-12-01

A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

Mechanical stimulation in the engineering of heart muscle.

PubMed

Liaw, Norman Yu; Zimmermann, Wolfram-Hubertus

2016-01-15

Recreating the beating heart in the laboratory continues to be a formidable bioengineering challenge. The fundamental feature of the heart is its pumping action, requiring considerable mechanical forces to compress a blood filled chamber with a defined in- and outlet. Ventricular output crucially depends on venous loading of the ventricles (preload) and on the force generated by the preloaded ventricles to overcome arterial blood pressure (afterload). The rate of contraction is controlled by the spontaneously active sinus node and transmission of its electrical impulses into the ventricles. The underlying principles for these physiological processes are described by the Frank-Starling mechanism and Bowditch phenomenon. It is essential to consider these principles in the design and evaluation of tissue engineered myocardium. This review focuses on current strategies to evoke mechanical loading in hydrogel-based heart muscle engineering. Copyright © 2015. Published by Elsevier B.V.

Rationally designed synthetic protein hydrogels with predictable mechanical properties.

PubMed

Wu, Junhua; Li, Pengfei; Dong, Chenling; Jiang, Heting; Bin Xue; Gao, Xiang; Qin, Meng; Wang, Wei; Bin Chen; Cao, Yi

2018-02-12

Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer research. However, it remains challenging to correlate the mechanical properties of protein hydrogels with the nanomechanics of individual building blocks. Here we use single-molecule force spectroscopy, protein engineering and theoretical modeling to prove that the mechanical properties of protein hydrogels are predictable based on the mechanical hierarchy of the cross-linkers and the load-bearing modules at the molecular level. These findings provide a framework for rationally designing protein hydrogels with independently tunable elasticity, extensibility, toughness and self-healing. Using this principle, we demonstrate the engineering of self-healable muscle-mimicking hydrogels that can significantly dissipate energy through protein unfolding. We expect that this principle can be generalized for the construction of protein hydrogels with customized mechanical properties for biomedical applications.

Electrical Grounding Architecture for Unmanned Spacecraft

NASA Technical Reports Server (NTRS)

1998-01-01

This handbook is approved for use by NASA Headquarters and all NASA Centers and is intended to provide a common framework for consistent practices across NASA programs. This handbook was developed to describe electrical grounding design architecture options for unmanned spacecraft. This handbook is written for spacecraft system engineers, power engineers, and electromagnetic compatibility (EMC) engineers. Spacecraft grounding architecture is a system-level decision which must be established at the earliest point in spacecraft design. All other grounding design must be coordinated with and be consistent with the system-level architecture. This handbook assumes that there is no one single 'correct' design for spacecraft grounding architecture. There have been many successful satellite and spacecraft programs from NASA, using a variety of grounding architectures with different levels of complexity. However, some design principles learned over the years apply to all types of spacecraft development. This handbook summarizes those principles to help guide spacecraft grounding architecture design for NASA and others.

Principles of Tendon Reconstruction Following Complex Trauma of the Upper Limb

PubMed Central

Chattopadhyay, Arhana; McGoldrick, Rory; Umansky, Elise; Chang, James

2015-01-01

Reconstruction of tendons following complex trauma to the upper limb presents unique clinical and research challenges. In this article, the authors review the principles guiding preoperative assessment, surgical reconstruction, and postoperative rehabilitation and management of the upper extremity. Tissue engineering approaches to address tissue shortages for tendon reconstruction are also discussed. PMID:25685101

Heparin Stimulates Elastogenesis: Application to Silk-Based Vascular Grafts

PubMed Central

Baughman, Cassandra; Kaplan, David L.; Castellot, John J.

2013-01-01

With over 500,000 coronary artery bypass grafts (CABG) performed annually in the United States alone, there is a significant clinical need for a small diameter tissue engineered vascular graft. A principle goal in tissue engineering is to develop materials and growth conditions that encourage appropriate re-cellularization and extracellular matrix formation in vivo. A particular challenge in vascular tissue engineering results from the inability of adult cells to produce elastin, as its expression is developmentally limited. We investigated factors to stimulate elastogenesis in vitro, and found that heparin treatment of adult human vascular smooth muscle cells promoted the formation of elastic fibers. This effect was heparin-specific, and dependent on cell density and growth state. We then applied this information to a silk-based construct, and found that immobilized heparin showed essentially identical biological effects to that of soluble heparin. These findings indicate that heparinized vascular grafts may promote elastin formation and regulate restenosis, in addition to heparin’s well-established antithrombotic properties. Given the increase in elastin mRNA level and the increase in extracellular elastin present, our data suggests that there may be multiple levels of elastin regulation that are mediated by heparin treatment. PMID:21600981

Re-engineering the Federal planning process: A total Federal planning strategy, integrating NEPA with modern management tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eccleston, C.H.

1997-09-05

The National Environmental Policy Act (NEPA) of 1969 was established by Congress more than a quarter of a century ago, yet there is a surprising lack of specific tools, techniques, and methodologies for effectively implementing these regulatory requirements. Lack of professionally accepted techniques is a principal factor responsible for many inefficiencies. Often, decision makers do not fully appreciate or capitalize on the true potential which NEPA provides as a platform for planning future actions. New approaches and modem management tools must be adopted to fully achieve NEPA`s mandate. A new strategy, referred to as Total Federal Planning, is proposed formore » unifying large-scale federal planning efforts under a single, systematic, structured, and holistic process. Under this approach, the NEPA planning process provides a unifying framework for integrating all early environmental and nonenvironmental decision-making factors into a single comprehensive planning process. To promote effectiveness and efficiency, modem tools and principles from the disciplines of Value Engineering, Systems Engineering, and Total Quality Management are incorporated. Properly integrated and implemented, these planning tools provide the rigorous, structured, and disciplined framework essential in achieving effective planning. Ultimately, the goal of a Total Federal Planning strategy is to construct a unified and interdisciplinary framework that substantially improves decision-making, while reducing the time, cost, redundancy, and effort necessary to comply with environmental and other planning requirements. At a time when Congress is striving to re-engineer the governmental framework, apparatus, and process, a Total Federal Planning philosophy offers a systematic approach for uniting the disjointed and often convoluted planning process currently used by most federal agencies. Potentially this approach has widespread implications in the way federal planning is approached.« less

A Study on the Self-Adaption Incentive Performance Salary

NASA Astrophysics Data System (ADS)

Zhang, Chuanming; Wang, Yang

In project managing, the performance salary management mode is often used to motivate project managers and other similar staff to improve performance or reduce the cost. But the engineering activities who own a lot of internal and external uncertain factors can not be known by the principle. It is difficult for to develop a suitable incentive target to project managers etch. This paper thinks that the manager self master the maximum of information on engineering activities. So this paper sets up an incentive model: the project managers themselves report performance objectives; owner gives the managers reward or punishment combined with their reported performance and actual performance. The model to ensure that the project manager is only accurate self reported its results to get the maximum profit. At the same time, it cans incentive managers to improve performance or reduce the cost. This paper focuses on setting up the model, analyzing the model parameters. And cite an example analyze them.

Who Would Have Thought? The Story of a Food Engineer.

PubMed

Lund, Daryl B

2017-02-28

Food engineering is a hybrid of food science and an engineering science, like chemical engineering in my particular case, resulting in the application of chemical engineering principles to food systems and their constituents. With the complexity of food and food processing, one generally narrows his or her interests, and my primary interests were in the kinetics of reactions important in foods, thermal processing, deposition of unwanted materials from food onto heated surfaces (fouling), and microwave heat transfer in baking. This review describes how I developed an interest in these topics and the contributions I have hopefully made to understanding food and to the application of engineering.

Upgrading the Space Shuttle Caution and Warning System

NASA Technical Reports Server (NTRS)

McCandless, Jeffrey W.; McCann, Robert S.; Hilty, Bruce T.

2005-01-01

A report describes the history and the continuing evolution of an avionic system aboard the space shuttle, denoted the caution and warning system, that generates visual and auditory displays to alert astronauts to malfunctions. The report focuses mainly on planned human-factors-oriented upgrades of an alphanumeric fault-summary display generated by the system. Such upgrades are needed because the display often becomes cluttered with extraneous messages that contribute to the difficulty of diagnosing malfunctions. In the first of two planned upgrades, the fault-summary display will be rebuilt with a more logical task-oriented graphical layout and multiple text fields for malfunction messages. In the second upgrade, information displayed will be changed, such that text fields will indicate only the sources (that is, root causes) of malfunctions; messages that are not operationally useful will no longer appear on the displays. These and other aspects of the upgrades are based on extensive collaboration among astronauts, engineers, and human-factors scientists. The report describes the human-factors principles applied in the upgrades.

Dialogue on sustainable development as part of engineering education: the relevance of the Finnish case : commentary on "a national collaboration process: Finnish engineering education for the benefit of people and environment".

PubMed

Geerts, Robert

2013-12-01

Society invests in the education of engineers because it is expected that the works of engineers will bring good results for society. Because the work of engineers is not value free or neutral, it is important that engineers are educated in the important principles of the social sciences and humanities. This education is essential for the awareness and understanding of what is good for society. Therefore the concept of sustainable development should be part of an education in engineering but only when the social sciences are also a part of it.

VR/LE engine with a variable R/L during a single cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rychter, T.J.; Teodorczyk, A.

1985-01-01

A new concept of an engine, called a Variable R/L Engine (VR/LE) is presented. The main feature of the engine is the continuous change of the crank-radius to connecting-rod-length ratio (R/L) during the single engine cycle. The variations of the phase angle result in changes of all the engine stroke lengths and also-they are causing the changes of the thermodynamic cycle of the engine. Therefore the phase angle variations make it possible to regulate continuously the compression ratio and the displacement volume of the engine within the range which depends on the engine mechanism geometry. The presented concept can bemore » applied to all the types of the IC piston engines, independently of their size and operation principle.« less

Search Engine Liability for Copyright Infringement

NASA Astrophysics Data System (ADS)

Fitzgerald, B.; O'Brien, D.; Fitzgerald, A.

The chapter provides a broad overview to the topic of search engine liability for copyright infringement. In doing so, the chapter examines some of the key copyright law principles and their application to search engines. The chapter also provides a discussion of some of the most important cases to be decided within the courts of the United States, Australia, China and Europe regarding the liability of search engines for copyright infringement. Finally, the chapter will conclude with some thoughts for reform, including how copyright law can be amended in order to accommodate and realise the great informative power which search engines have to offer society.

Parts plus pipes: synthetic biology approaches to metabolic engineering

PubMed Central

Boyle, Patrick M.; Silver, Pamela A.

2011-01-01

Synthetic biologists combine modular biological “parts” to create higher-order devices. Metabolic engineers construct biological “pipes” by optimizing the microbial conversion of basic substrates to desired compounds. Many scientists work at the intersection of these two philosophies, employing synthetic devices to enhance metabolic engineering efforts. These integrated approaches promise to do more than simply improve product yields; they can expand the array of products that are tractable to produce biologically. In this review, we explore the application of synthetic biology techniques to next-generation metabolic engineering challenges, as well as the emerging engineering principles for biological design. PMID:22037345

Applying the design-build-test paradigm in microbiome engineering.

PubMed

Pham, Hoang Long; Ho, Chun Loong; Wong, Adison; Lee, Yung Seng; Chang, Matthew Wook

2017-12-01

The recently discovered roles of human microbiome in health and diseases have inspired research efforts across many disciplines to engineer microbiome for health benefits. In this review, we highlight recent progress in human microbiome research and how modifications to the microbiome could result in implications to human health. Furthermore, we discuss the application of a 'design-build-test' framework to expedite microbiome engineering efforts by reviewing current literature on three key aspects: design principles to engineer the human microbiome, methods to engineer microbiome with desired functions, and analytical techniques to examine complex microbiome samples. Copyright © 2017 Elsevier Ltd. All rights reserved.

International Conference on Bio-Medical Instrumentation and related Engineering and Physical Sciences (BIOMEP 2015)

NASA Astrophysics Data System (ADS)

2015-09-01

The International Conference on Bio-Medical Instrumentation and related Engineering and Physical Sciences (BIOMEP 2015) took place in the Technological Educational Institute (TEI) of Athens, Greece on June 18-20, 2015 and was organized by the Department of Biomedical Engineering. The scope of the conference was to provide a forum on the latest developments in Biomedical Instrumentation and related principles of Physical and Engineering sciences. Scientists and engineers from academic, industrial and health disciplines were invited to participate in the Conference and to contribute both in the promotion and dissemination of the scientific knowledge.

Fault Management Guiding Principles

NASA Technical Reports Server (NTRS)

Newhouse, Marilyn E.; Friberg, Kenneth H.; Fesq, Lorraine; Barley, Bryan

2011-01-01

Regardless of the mission type: deep space or low Earth orbit, robotic or human spaceflight, Fault Management (FM) is a critical aspect of NASA space missions. As the complexity of space missions grows, the complexity of supporting FM systems increase in turn. Data on recent NASA missions show that development of FM capabilities is a common driver for significant cost overruns late in the project development cycle. Efforts to understand the drivers behind these cost overruns, spearheaded by NASA's Science Mission Directorate (SMD), indicate that they are primarily caused by the growing complexity of FM systems and the lack of maturity of FM as an engineering discipline. NASA can and does develop FM systems that effectively protect mission functionality and assets. The cost growth results from a lack of FM planning and emphasis by project management, as well the maturity of FM as an engineering discipline, which lags behind the maturity of other engineering disciplines. As a step towards controlling the cost growth associated with FM development, SMD has commissioned a multi-institution team to develop a practitioner's handbook representing best practices for the end-to-end processes involved in engineering FM systems. While currently concentrating primarily on FM for science missions, the expectation is that this handbook will grow into a NASA-wide handbook, serving as a companion to the NASA Systems Engineering Handbook. This paper presents a snapshot of the principles that have been identified to guide FM development from cradle to grave. The principles range from considerations for integrating FM into the project and SE organizational structure, the relationship between FM designs and mission risk, and the use of the various tools of FM (e.g., redundancy) to meet the FM goal of protecting mission functionality and assets.

``Dissection'' of a Hair Dryer

NASA Astrophysics Data System (ADS)

Eisenstein, Stan; Simpson, Jeff

2008-12-01

The electrical design of the common hair dryer is based almost entirely on relatively simple principles learned in introductory physics classes. Just as biology students dissect a frog to see the principles of anatomy in action, physics students can "dissect" a hair dryer to see how principles of electricity are used in a real system. They can discover how engineers solve problems such as how to vary between low and high heat and fan speed by simply moving the position of a single switch. Principles of alternating versus direct current, series and parallel circuits, electrical safety, voltage dividing, ac rectification, power, and measurement of resistance and continuity all come in to play.

Electronic collaboration: Some effects of telecommunication media and machine intelligence on team performance

NASA Technical Reports Server (NTRS)

Wellens, A. Rodney

1991-01-01

Both NASA and DoD have had a long standing interest in teamwork, distributed decision making, and automation. While research on these topics has been pursued independently, it is becoming increasingly clear that the integration of social, cognitive, and human factors engineering principles will be necessary to meet the challenges of highly sophisticated scientific and military programs of the future. Images of human/intelligent-machine electronic collaboration were drawn from NASA and Air Force reports as well as from other sources. Here, areas of common concern are highlighted. A description of the author's research program testing a 'psychological distancing' model of electronic media effects and human/expert system collaboration is given.

Strategies for a Creative Future with Computer Science, Quality Design and Communicability

NASA Astrophysics Data System (ADS)

Cipolla Ficarra, Francisco V.; Villarreal, Maria

In the current work is presented the importance of the two-way triad between computer science, design and communicability. It is demonstrated how the principles of quality of software engineering are not universal since they are disappearing inside university training. Besides, a short analysis of the term "creativity" males apparent the existence of plagiarism as a human factor that damages the future of communicability applied to the on-line and off-line contents of the open software. A set of measures and guidelines are presented so that the triad works again correctly in the next years to foster the qualitative design of the interactive systems on-line and/or off-line.

Performance Criteria of Nuclear Space Propulsion Systems

NASA Astrophysics Data System (ADS)

Shepherd, L. R.

Future exploration of the solar system on a major scale will require propulsion systems capable of performance far greater than is achievable with the present generation of rocket engines using chemical propellants. Viable missions going deeper into interstellar space will be even more demanding. Propulsion systems based on nuclear energy sources, fission or (eventually) fusion offer the best prospect for meeting the requirements. The most obvious gain coming from the application of nuclear reactions is the possibility, at least in principle, of obtaining specific impulses a thousandfold greater than can be achieved in chemically energised rockets. However, practical considerations preclude the possibility of exploiting the full potential of nuclear energy sources in any engines conceivable in terms of presently known technology. Achievable propulsive power is a particularly limiting factor, since this determines the acceleration that may be obtained. Conventional chemical rocket engines have specific propulsive powers (power per unit engine mass) in the order of gigawatts per tonne. One cannot envisage the possibility of approaching such a level of performance by orders of magnitude in presently conceivable nuclear propulsive systems. The time taken, under power, to reach a given terminal velocity is proportional to the square of the engine's exhaust velocity and the inverse of its specific power. An assessment of various nuclear propulsion concepts suggests that, even with the most optimistic assumptions, it could take many hundreds of years to attain the velocities necessary to reach the nearest stars. Exploration within a range of the order of a thousand AU, however, would appear to offer viable prospects, even with the low levels of specific power of presently conceivable nuclear engines.

Speed, Acceleration, and Velocity: Level II, Unit 9, Lesson 1; Force, Mass, and Distance: Lesson 2; Types of Motion and Rest: Lesson 3; Electricity and Magnetism: Lesson 4; Electrical, Magnetic, and Gravitational Fields: Lesson 5; The Conservation and Conversion of Matter and Energy: Lesson 6; Simple Machines and Work: Lesson 7; Gas Laws: Lesson 8; Principles of Heat Engines: Lesson 9; Sound and Sound Waves: Lesson 10; Light Waves and Particles: Lesson 11; Program. A High.....

ERIC Educational Resources Information Center

Manpower Administration (DOL), Washington, DC. Job Corps.

This self-study program for high-school level contains lessons on: Speed, Acceleration, and Velocity; Force, Mass, and Distance; Types of Motion and Rest; Electricity and Magnetism; Electrical, Magnetic, and Gravitational Fields; The Conservation and Conversion of Matter and Energy; Simple Machines and Work; Gas Laws; Principles of Heat Engines;…

Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room.

PubMed

Cengiz, Ibrahim Fatih; Pereira, Hélder; de Girolamo, Laura; Cucchiarini, Magali; Espregueira-Mendes, João; Reis, Rui L; Oliveira, Joaquim Miguel

2018-05-22

Orthopaedic disorders are very frequent, globally found and often partially unresolved despite the substantial advances in science and medicine. Their surgical intervention is multifarious and the most favourable treatment is chosen by the orthopaedic surgeon on a case-by-case basis depending on a number of factors related with the patient and the lesion. Numerous regenerative tissue engineering strategies have been developed and studied extensively in laboratory through in vitro experiments and preclinical in vivo trials with various established animal models, while a small proportion of them reached the operating room. However, based on the available literature, the current strategies have not yet achieved to fully solve the clinical problems. Thus, the gold standards, if existing, remain unchanged in the clinics, notwithstanding the known limitations and drawbacks. Herein, the involvement of regenerative tissue engineering in the clinical orthopaedics is reviewed. The current challenges are indicated and discussed in order to describe the current disequilibrium between the needs and solutions made available in the operating room. Regenerative tissue engineering is a very dynamic field that has a high growth rate and a great openness and ability to incorporate new technologies with passion to edge towards the Holy Grail that is functional tissue regeneration. Thus, the future of clinical solutions making use of regenerative tissue engineering principles for the management of orthopaedic disorders is firmly supported by the clinical need.

Special Quasirandom Structures to Study the (K0.5Na0.5)NbO3 Random Alloy

DTIC Science & Technology

2014-07-31

first-principles discovery of novel materials with properties such as ferroelectricity, piezoelectricity, ferromagnetism , and thermoelectricity. For...Tan,1 Valentino R. Cooper,4,* and Scott P. Beckman1,† 1Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011, USA...2Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 36211, USA 3Department of Materials Science and Engineering

Principles of Water Quality Control.

ERIC Educational Resources Information Center

Tebbutt, T. H. Y.

This book is designed as a text for undergraduate civil engineering courses and as preliminary reading for postgraduate courses in public health engineering and water resources technology. It is also intended to be of value to workers already in the field and to students preparing for the examinations of the Institute of Water Pollution Control…

Polymeric Medical Sutures: An Exploration of Polymers and Green Chemistry

ERIC Educational Resources Information Center

Knutson, Cassandra M.; Schneiderman, Deborah K.; Yu, Ming; Javner, Cassidy H.; Distefano, Mark D.; Wissinger, Jane E.

2017-01-01

With new K-12 national science standards emerging, there is an increased need for experiments that integrate engineering into the context of society. Here we describe a chemistry experiment that combines science and engineering principles while introducing basic polymer and green chemistry concepts. Using medical sutures as a platform for…

Implementing Assessment Engineering in the Uniform Certified Public Accountant (CPA) Examination

ERIC Educational Resources Information Center

Burke, Matthew; Devore, Richard; Stopek, Josh

2013-01-01

This paper describes efforts to bring principled assessment design to a large-scale, high-stakes licensure examination by employing the frameworks of Assessment Engineering (AE), the Revised Bloom's Taxonomy (RBT), and Cognitive Task Analysis (CTA). The Uniform CPA Examination is practice-oriented and focuses on the skills of accounting. In…

An industrial engineering approach to laboratory automation for high throughput screening

PubMed Central

Menke, Karl C.

2000-01-01

Across the pharmaceutical industry, there are a variety of approaches to laboratory automation for high throughput screening. At Sphinx Pharmaceuticals, the principles of industrial engineering have been applied to systematically identify and develop those automated solutions that provide the greatest value to the scientists engaged in lead generation. PMID:18924701

Bioinspired engineering of exploration systems: a horizon sensor/attitude reference system based on the dragonfly Ocelli for Mars exploration applications

NASA Technical Reports Server (NTRS)

Thakoor, S.; Zornetzer, S.; Hine, B.; Chahl, J.; Stange, G.

2002-01-01

The intent of Bio-inspired Engineering of Exploration Systems (BEES) is to distill the principles found in successful, nature-tested mechanisms of specific crucial functions that are hard to accomplish by conventional methods, but accomplished rather deftly in nature by biological oganisms.

Educational Modules in Tissue Engineering Based on the "How People Learn" Framework

ERIC Educational Resources Information Center

Birol, Gulnur; Liu, Shu Q.; Smith, H. David; Hirsch, Penny

2006-01-01

This paper describes an educational package for use in tertiary level tissue engineering education. Current learning science principles and theory were employed in the design process of these educational tools. Each module started with a challenge statement designed to motivate students and consisted of laboratory exercises centered on the "How…

Synthetic Biology: Knowledge Accessed by Everyone (Open Sources)

ERIC Educational Resources Information Center

Sánchez Reyes, Patricia Margarita

2016-01-01

Using the principles of biology, along with engineering and with the help of computer, scientists manage to copy. DNA sequences from nature and use them to create new organisms. DNA is created through engineering and computer science managing to create life inside a laboratory. We cannot dismiss the role that synthetic biology could lead in…

Everyday Engineering: What Makes a Bic Click?

ERIC Educational Resources Information Center

Moyer, Richard; Everett, Susan

2009-01-01

The ballpoint pen is an ideal example of simple engineering that we use everyday. But is it really so simple? The ballpoint pen is a remarkable combination of technology and science. Its operation uses several scientific principles related to chemistry and physics, such as properties of liquids and simple machines. They represent significant…

Exploring Students' Engineering Designs through Open-Ended Assignments

ERIC Educational Resources Information Center

Puente, S. M. Gómez; Jansen, J. W.

2017-01-01

This paper aims at presenting the experience of the Power Conversion project in teaching students to design a proof-of-principle contactless energy transfer system for the charging of electrical vehicles. The Power Conversion is a second-year electrical engineering (EE) project in which students are to gather and apply EE knowledge to design and…

Geotechnical Engineering Circular No. 3: Design Guidance. Geotechnical Earthquake Engineering for Highways. Volume I - Design Principles

DOT National Transportation Integrated Search

1995-01-01

In order to obtain regional perspective on the major problems and issues to be addressed, a series of nine regional round tables were convened across the nation. One of these was held in Norfolk, VA, on June 11, 1993. The primary focus of this meetin...

Software Engineering Design Principles Applied to Instructional Design: What Can We Learn from Our Sister Discipline?

ERIC Educational Resources Information Center

Adnan, Nor Hafizah; Ritzhaupt, Albert D.

2018-01-01

The failure of many instructional design initiatives is often attributed to poor instructional design. Current instructional design models do not provide much insight into design processes for creating e-learning instructional solutions. Given the similarities between the fields of instructional design and software engineering, instructional…

Teaching Technical Writing in a Lab Course in Chemical Engineering

ERIC Educational Resources Information Center

Lombardo, Stephen J.

2010-01-01

Techniques are presented for improving the technical writing of chemical engineering students enrolled in an undergraduate laboratory course. The principles of writing covered are adopted from the book, Style: Lessons in Clarity and Grace, by Joseph M. Williams: General examples of writing are taken from this book and then are recast into examples…

DIESEL ENGINE SYSTEMS. AGRICULTURAL MACHINERY--SERVICE OCCUPATIONS, MODULE NUMBER 15.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center for Vocational and Technical Education.

ONE OF A SERIES DESIGNED TO HELP TEACHERS PREPARE POSTSECONDARY STUDENTS FOR AGRICULTURAL MACHINERY SERVICE OCCUPATIONS AS PARTS MEN, MECHANICS, MECHANIC'S HELPERS, AND SERVICE SUPERVISORS, THIS GUIDE AIMS TO DEVELOP STUDENT UNDERSTANDING OF THE CONSTRUCTION AND OPERATING PRINCIPLES OF DIESEL ENGINES. IT WAS DEVELOPED BY A NATIONAL TASK FORCE ON…

PBL-SEE: An Authentic Assessment Model for PBL-Based Software Engineering Education

ERIC Educational Resources Information Center

dos Santos, Simone C.

2017-01-01

The problem-based learning (PBL) approach has been successfully applied to teaching software engineering thanks to its principles of group work, learning by solving real problems, and learning environments that match the market realities. However, the lack of well-defined methodologies and processes for implementing the PBL approach represents a…

Behavior Management in the Adaptive Environment: Evaluation of a School-Community Program for Adjudicated Youth.

ERIC Educational Resources Information Center

Lazzaro, Edward L.; Hosie, Thomas W.

1979-01-01

The principles of behavioral engineering were applied to create a program for delinquent youth to facilitate their adjustment into the regular pattern of the normal public school. Results indicated that the behavioral engineering method produced a significantly greater number of placements and significantly less recidivism. (Author)

A Theory of Information Quality and a Framework for Its Implementation in the Requirements Engineering Process

ERIC Educational Resources Information Center

Grenn, Michael W.

2013-01-01

This dissertation introduces a theory of information quality to explain macroscopic behavior observed in the systems engineering process. The theory extends principles of Shannon's mathematical theory of communication [1948] and statistical mechanics to information development processes concerned with the flow, transformation, and meaning of…

Elementary Science Teachers' Integration of Engineering Design into Science Instruction: Results from a Randomised Controlled Trial

ERIC Educational Resources Information Center

Maeng, Jennifer L.; Whitworth, Brooke A.; Gonczi, Amanda L.; Navy, Shannon L.; Wheeler, Lindsay B.

2017-01-01

This randomised controlled trial used a mixed-methods approach to investigate the frequency and how elementary teachers integrated engineering design (ED) principles into their science instruction following professional development (PD). The ED components of the PD were aligned with Cunningham and Carlsen's [(2014). "Teaching engineering…

Human Systems Engineering: A Leadership Model for Collaboration and Change.

ERIC Educational Resources Information Center

Clark, Karen L.

Human systems engineering (HSE) was created to introduce a new way of viewing collaboration. HSE emphasizes the role of leaders who welcome risk, commit to achieving positive change, and help others achieve change. The principles of HSE and its successful application to the collaborative process were illustrated through a case study representing a…

Notes on Advanced Engineering Education

ERIC Educational Resources Information Center

Klimenko, A. Y.

2017-01-01

This article reviews history, analyses principles and presents a modern interpretation of advanced engineering education (AEE). AEE originated in France, was adapted in Germany and reached its zenith in the second half of the twentieth century as part of technological efforts induced by the space race. AEE is an enhanced form of education aimed at…

From Science To Design: Systems Engineering For The Lsst

NASA Astrophysics Data System (ADS)

Claver, Chuck F.; Axelrod, T.; Fouts, K.; Kantor, J.; Nordby, M.; Sebag, J.; LSST Collaboration

2009-01-01

The LSST is a universal-purpose survey telescope that will address scores of scientific missions. To assist the technical teams to convergence to a specific engineering design, the LSST Science Requirements Document (SRD) selects four stressing principle scientific missions: 1) Constraining Dark Matter and Dark Energy; 2) taking an Inventory of the Solar System; 3) Exploring the Transient Optical Sky; and 4) mapping the Milky Way. From these 4 missions the SRD specifies the needed requirements for single images and the full 10 year survey that enables a wide range of science beyond the 4 principle missions. Through optical design and analysis, operations simulation, and throughput modeling the systems engineering effort in the LSST has largely focused on taking the SRD specifications and deriving system functional requirements that define the system design. A Model Based Systems Engineering approach with SysML is used to manage the flow down of requirements from science to system function to sub-system. The rigor of requirements flow and management assists the LSST in keeping the overall scope, hence budget and schedule, under control.

Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors.

PubMed

Mannan, Ahmad A; Liu, Di; Zhang, Fuzhong; Oyarzún, Diego A

2017-10-20

Metabolite biosensors are central to current efforts toward precision engineering of metabolism. Although most research has focused on building new biosensors, their tunability remains poorly understood and is fundamental for their broad applicability. Here we asked how genetic modifications shape the dose-response curve of biosensors based on metabolite-responsive transcription factors. Using the lac system in Escherichia coli as a model system, we built promoter libraries with variable operator sites that reveal interdependencies between biosensor dynamic range and response threshold. We developed a phenomenological theory to quantify such design constraints in biosensors with various architectures and tunable parameters. Our theory reveals a maximal achievable dynamic range and exposes tunable parameters for orthogonal control of dynamic range and response threshold. Our work sheds light on fundamental limits of synthetic biology designs and provides quantitative guidelines for biosensor design in applications such as dynamic pathway control, strain optimization, and real-time monitoring of metabolism.

Environmental Impact Assessment: Teaching the Principles and Practices by Means of a Role-Playing Case Study

ERIC Educational Resources Information Center

Crittenden, Barry D.; England, Richard

2005-01-01

The principles and practices of environmental impact assessment are best taught to chemical engineering undergraduate students by means of a role­-playing case study. Many suitable examples are available from public sources. The planning appeal process has been selected so as to introduce an adversarial style involving cross-­examination on…

Neural network controller development and implementation for spark ignition engines with high EGR levels.

PubMed

Vance, Jonathan Blake; Singh, Atmika; Kaul, Brian C; Jagannathan, Sarangapani; Drallmeier, James A

2007-07-01

Past research has shown substantial reductions in the oxides of nitrogen (NOx) concentrations by using 10%-25% exhaust gas recirculation (EGR) in spark ignition (SI) engines (see Dudek and Sain, 1989). However, under high EGR levels, the engine exhibits strong cyclic dispersion in heat release which may lead to instability and unsatisfactory performance preventing commercial engines to operate with high EGR levels. A neural network (NN)-based output feedback controller is developed to reduce cyclic variation in the heat release under high levels of EGR even when the engine dynamics are unknown by using fuel as the control input. A separate control loop was designed for controlling EGR levels. The stability analysis of the closed-loop system is given and the boundedness of the control input is demonstrated by relaxing separation principle, persistency of excitation condition, certainty equivalence principle, and linear in the unknown parameter assumptions. Online training is used for the adaptive NN and no offline training phase is needed. This online learning feature and model-free approach is used to demonstrate the applicability of the controller on a different engine with minimal effort. Simulation results demonstrate that the cyclic dispersion is reduced significantly using the proposed controller when implemented on an engine model that has been validated experimentally. For a single cylinder research engine fitted with a modern four-valve head (Ricardo engine), experimental results at 15% EGR indicate that cyclic dispersion was reduced 33% by the controller, an improvement of fuel efficiency by 2%, and a 90% drop in NOx from stoichiometric operation without EGR was observed. Moreover, unburned hydrocarbons (uHC) drop by 6% due to NN control as compared to the uncontrolled scenario due to the drop in cyclic dispersion. Similar performance was observed with the controller on a different engine.

Regenerative endodontics--Creating new horizons.

PubMed

Dhillon, Harnoor; Kaushik, Mamta; Sharma, Roshni

2016-05-01

Trauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non-surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%-15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp. It utilizes mesenchymal stem cells, growth factors, and organ tissue culture to provide treatment. Potential treatment modalities include induction of blood clot for pulp revascularization, scaffold aided regeneration, and pulp implantation. Although in its infancy, successful treatment of damaged pulp tissue has been performed using principles of regenerative endodontics. This field is dynamic and exciting with the ability to shape the future of endodontics. This article highlights the fundamental concepts, protocol for treatment, and possible avenues for research in regenerative endodontics. © 2015 Wiley Periodicals, Inc.

Thermoelectric properties of 2H-CuGaO2 for device applications: A first principle TB-mBJ potential study

NASA Astrophysics Data System (ADS)

Bhamu, K. C.; Praveen, C. S.

2017-12-01

Here we report the structural, electronic, optical, and thermoelectric properties of delafossite type 2H-CuGaO2 using first principles calculations. The present calculation predict an indirect band gap of 1.20 eV and a direct band gap of 3.48 eV. A detailed analysis of the electronic structure is provided based on atom and orbital projected density of states. Frequency dependent dielectric functions, refractive index, and absorption coefficient as a function of photon energy are discussed. The thermoelectric properties with power factor, and the figure of merit are reported as a function of chemical potential in the region ± 0.195 (μ -EF) eV at constant temperature of 300 and 800 K. The thermoelectric properties shows that 2H-CuGaO2 could be potential candidate for engineering devises operating at high temperature for the chemical potential in the range of ± 0.055 (μ -EF) eV and beyond this range the thermoelectric performance of 2H-CuGaO2 get reduced.

[Thermodynamic principles and physiologic criteria for the use of heat engines to drive the ventricles of an artificial heart].

PubMed

Kiselev, Iu M; Mordashev, V M; Osipov, A P; Shumakov, V I

1990-01-01

The authors review the thermodynamic bases and physiological limitations of the applicability of thermal engines for driving artificial heart ventricles. Show that the thermodynamic characteristics of Stirling and Brighton cycles do not make it possible to effectively use cycle-based engines in the artificial heart. A steam engine operating in accordance with the Rankine cycle may be regarded as an optimum type engine for that purpose. Demonstrate that according to the rules of physiology, use should be made of a separate driving of artificial heart ventricles by two independently operating steam engines. Provide the characteristics of the Soviet artificial heart "MIKRON" acceptable for implantation into the orthotopic position.

Environmental engineering: A profession in transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mackay, D.

1996-11-01

This 50th Industrial Waste Conference at Purdue gives one an opportunity and excuse to reflect on progress in Environmental Engineering and speculate on future changes. The author suggests that during this 50-year period Environmental Engineering has emerged as a discrete and creditable body of knowledge, practice, and academic study. In this review he presents a personal view of the evolution of Environmental Engineering and its present status. He also suggests some future directions and principles which may prove useful, especially in the academic world. The paper discusses the sphere of the environmental engineer, the social incentive, the academic curriculum, environmentalmore » engineers and society, the chlorine controversy, research, and the electronic revolution.« less

Integrating Rehabilitation Engineering Technology With Biologics

PubMed Central

Collinger, Jennifer L.; Dicianno, Brad E.; Weber, Douglas J.; Cui, Xinyan Tracy; Wang, Wei; Brienza, David M.; Boninger, Michael L.

2017-01-01

Rehabilitation engineers apply engineering principles to improve function or to solve challenges faced by persons with disabilities. It is critical to integrate the knowledge of biologics into the process of rehabilitation engineering to advance the field and maximize potential benefits to patients. Some applications in particular demonstrate the value of a symbiotic relationship between biologics and rehabilitation engineering. In this review we illustrate how researchers working with neural interfaces and integrated prosthetics, assistive technology, and biologics data collection are currently integrating these 2 fields. We also discuss the potential for further integration of biologics and rehabilitation engineering to deliver the best technologies and treatments to patients. Engineers and clinicians must work together to develop technologies that meet clinical needs and are accessible to the intended patient population. PMID:21703573

Building Better Scientists through Cross-Disciplinary Collaboration in Synthetic Biology: A Report from the Genome Consortium for Active Teaching Workshop 2010

ERIC Educational Resources Information Center

Wolyniak, Michael J.; Alvarez, Consuelo J.; Chandrasekaran, Vidya; Grana, Theresa M.; Holgado, Andrea; Jones, Christopher J.; Morris, Robert W.; Pereira, Anil L.; Stamm, Joyce; Washington, Talitha M.; Yang, Yixin

2010-01-01

Synthetic biology is the application of engineering and mathematical principles to develop novel biological devices and circuits. What separates synthetic biology from traditional molecular biology is the development of standardized interchangeable DNA "parts," just as advances in engineering in the nineteenth century brought about standardized…

1000507

NASA Image and Video Library

2010-04-01

NASA ADMINISTRATOR CHARLES BOLDEN LOOKS ON AS BALL AEROSPACE TECHNOLOGIES CORPORATION PRINCIPLE OPTICAL ENGINEER DAVE CHANEY EXPLAINS HOW THE JAMES WEBB SPACE TELESCOPE MIRROR SEGMENTS ARE TESTED IN MARSHALL'S X-RAY AND CRYOGENIC FACILITY. PICTURED FROM LEFT: HELEN COLE, WEBB TELESCOPE ACTIVITIES PROJECT MANAGER AT MARSHALL; CHARLES SCALES, ASSOCIATE DEPUTY ADMINISTRATOR: ROBERT LIGHTFOOT, CENTER DIRECTOR; CHARLES BOLDEN, NASA ADMINISTRATOR; DAVE CHANEY, BALL OPTICAL ENGINEER.

Innovation Development--An Action Learning Programme for Medical Scientists and Engineers

ERIC Educational Resources Information Center

Beniston, Lee; Ellwood, Paul; Gold, Jeff; Roberts, James; Thorpe, Richard

2014-01-01

There is increasing evidence that action learning is valuable in a higher education setting. This paper goes on to report a personal development programme, based on principles of critical action learning, where the aim is to equip early-career scientists and engineers working in a university setting with the knowledge, skills and confidence to…

Cryogenic engineering

NASA Astrophysics Data System (ADS)

Beliakov, V. P.

Recent developments and trends in cryogenic engineering are reviewed, with emphasis on the role of cryogenics in power generation, machine building, chemistry, and metallurgy. Several cryogenic systems are described, including air-separation apparatus, cryogenic storage systems, cryothermovacuum devices, and the cryogenic systems of superconducting devices. The theoretical principles underlying the design of cryogenic systems are examined, along with the theory for the processes involved.

Synthesis of engineering designs of drilling facilities

NASA Astrophysics Data System (ADS)

Porozhsky, K.

2018-03-01

The article sets forth key principles of engineering of drilling equipment based on successive analysis of the goals of the production method, technologies of its implementation and conditions of mineral mining using a new approach to systematization of drilling methods. Potential advancement in the technologies and equipment of drilling is illustrated in terms of oil-well drilling.

Bionic Manufacturing: Towards Cyborg Cells and Sentient Microbots.

PubMed

Srivastava, Sarvesh Kumar; Yadav, Vikramaditya G

2018-05-01

Bio-inspired engineering applies biological design principles towards developing engineering solutions but is not practical as a manufacturing paradigm. We advocate 'bionic manufacturing', a synergistic fusion of biotic and abiotic components, to transition away from bio-inspiration toward bio-augmentation to address current limitations in bio-inspired manufacturing. Copyright © 2017 Elsevier Ltd. All rights reserved.

How Model Can Help Inquiry--A Qualitative Study of Model Based Inquiry Learning (Mobile) in Engineering Education

ERIC Educational Resources Information Center

Gong, Yu

2017-01-01

This study investigates how students can use "interactive example models" in inquiry activities to develop their conceptual knowledge about an engineering phenomenon like electromagnetic fields and waves. An interactive model, for example a computational model, could be used to develop and teach principles of dynamic complex systems, and…

Introducing High School Students to Chemical Engineering Kinetics with a Simple Experiment-Based Smartphone Education Application

ERIC Educational Resources Information Center

Stanley, Simone; Ymele-Leki, Patrick

2017-01-01

A community outreach project was integrated in a District of Columbia public schools summer internship program for students from underrepresented minorities in STEM. The project introduced these students to fundamental engineering principles by leveraging a smartphone application (App) so readily accessible and attractive to them that it boosted…

General Mechanical Repair. Minor Automotive Maintenance, Small Engine [Repair, and] Welding: Student Manual.

ERIC Educational Resources Information Center

Hamlin, Larry

This document is a student manual for a general mechanical repair course. Following a list of common essential elements of trade and industrial education, the manual is divided into three sections. The first section, on minor automotive maintenance, contains 13 units: automotive shop safety; engine principles; fuel system operation and repair;…

Engineering Encounters: Designing Healthy Ice Pops. A STEM Enrichment Project for Second Graders Incorporates Nutrition and Design Principles

ERIC Educational Resources Information Center

Bubnick, Laura; Enneking, Katie; Egbers, Julie

2016-01-01

Science, technology, engineering, and math (STEM) education piques students' innate curiosity and opens their eyes to hundreds of career possibilities. This column presents ideas and techniques to enhance your science teaching. This month's issue shares information about a STEM enrichment project for second graders that incorporates nutrition and…

Teaching Applied Genetics and Molecular Biology to Agriculture Engineers. Application of the European Credit Transfer System

ERIC Educational Resources Information Center

Weiss, J.; Egea-Cortines, M.

2008-01-01

We have been teaching applied molecular genetics to engineers and adapted the teaching methodology to the European Credit Transfer System. We teach core principles of genetics that are universal and form the conceptual basis of most molecular technologies. The course then teaches widely used techniques and finally shows how different techniques…

Ten recommendations for software engineering in research.

PubMed

Hastings, Janna; Haug, Kenneth; Steinbeck, Christoph

2014-01-01

Research in the context of data-driven science requires a backbone of well-written software, but scientific researchers are typically not trained at length in software engineering, the principles for creating better software products. To address this gap, in particular for young researchers new to programming, we give ten recommendations to ensure the usability, sustainability and practicality of research software.

An Evaluation of a Course That Introduces Undergraduate Students to Authentic Aerospace Engineering Research

ERIC Educational Resources Information Center

Mena, Irene B.; Schmitz, Sven; McLaughlin, Dennis

2015-01-01

This paper describes the implementation and assessment of an aerospace engineering course in which undergraduate students worked on research projects with graduate research mentors. The course was created using the principles from cooperative learning and project-based learning, and consisted of students working in small groups on a complex,…

Development of a Pedagogical Model to Help Engineering Faculty Design Interdisciplinary Curricula

ERIC Educational Resources Information Center

Navarro, Maria; Foutz, Timothy; Thompson, Sidney; Singer, Kerri Patrick

2016-01-01

The purpose of this study was to develop a model to help engineering faculty overcome the challenges they face when asked to design and implement interdisciplinary curricula. Researchers at a U.S. University worked with an Interdisciplinary Consultant Team and prepared a steering document with Guiding Principles and Essential Elements for the…

The Role of Authenticity in Design-Based Learning Environments: The Case of Engineering Education

ERIC Educational Resources Information Center

Strobel, J.; Wang, J.; Weber, N. R.; Dyehouse, M.

2013-01-01

The term "authenticity" is pervasive in the education literature in general and specifically in the design education and engineering education literature; yet, the construct is often used un-reflected and ill defined. The purpose of this paper is (1) to critically examine current conceptualizations of authenticity as principles to design learning…

Sodium heat engine system: Space application

NASA Astrophysics Data System (ADS)

Betz, Bryan H.; Sungu, Sabri; Vu, Hung V.

1994-08-01

This paper explores the possibility of utilizing the Sodium Heat Engine (SHE) or known as AMTEC (Alkali Metal Thermoelectric Converter), for electrical power generation in ``near earth'' geosynchronous orbit. The Sodium Heat Engine principle is very flexible and adapts well to a variety of physical geometries. The proposed system can be easily folded and then deployed into orbit without the need for on site assembly in space. Electric power generated from SHE engine can be used in communication satellites, in space station, and other applications such as electrical recharging of vehicles in space is one of the applications the Sodium Heat Engine could be adapted to serve.

Overview of NASA Lewis Research Center free-piston Stirling engine technology activities applicable to space power systems

NASA Technical Reports Server (NTRS)

Slaby, Jack G.

1987-01-01

A brief overview is presented of the development and technological activities of the free-piston Stirling engine. The engine started as a small scale fractional horsepower engine which demonstrated basic engine operating principles and the advantages of being hermetically sealed, highly efficient, and simple. It eventually developed into the free piston Stirling engine driven heat pump, and then into the SP-100 Space Reactor Power Program from which came the Space Power Demonstrator Engine (SPDE). The SPDE successfully operated for over 300 hr and delivered 20 kW of PV power to an alternator plunger. The SPDE demonstrated that a dynamic power conversion system can, with proper design, be balanced; and the engine performed well with externally pumped hydrostatic gas bearings.

Modularization of genetic elements promotes synthetic metabolic engineering.

PubMed

Qi, Hao; Li, Bing-Zhi; Zhang, Wen-Qian; Liu, Duo; Yuan, Ying-Jin

2015-11-15

In the context of emerging synthetic biology, metabolic engineering is moving to the next stage powered by new technologies. Systematical modularization of genetic elements makes it more convenient to engineer biological systems for chemical production or other desired purposes. In the past few years, progresses were made in engineering metabolic pathway using synthetic biology tools. Here, we spotlighted the topic of implementation of modularized genetic elements in metabolic engineering. First, we overviewed the principle developed for modularizing genetic elements and then discussed how the genetic modules advanced metabolic engineering studies. Next, we picked up some milestones of engineered metabolic pathway achieved in the past few years. Last, we discussed the rapid raised synthetic biology field of "building a genome" and the potential in metabolic engineering. Copyright © 2015 Elsevier Inc. All rights reserved.

Second thoughts about privacy, safety and deception

NASA Astrophysics Data System (ADS)

Sorell, Tom; Draper, Heather

2017-07-01

In this paper, we point out some difficulties with interpreting three of five principles formulated at a retreat on robot ethics sponsored by the Arts and Humanities Council and the Engineering and Physical Sciences Research Council. We also attempt to iron out some conflicts between the principles. Some of the difficulties arise from the way that the autonomy of robot users - their capacity to live by their own choices - can be a goal in the design of care robots. We discuss (a) problems for Principle 2 that arise from competing legal and philosophical understandings of privacy; (b) a tension between privacy and safety (Principles 2 and 3) and (c) some scepticism about the application of Principle 4, which addresses robot design that might result in the deception of vulnerable users.

Structure and Management of an Engineering Senior Design Course.

PubMed

Tanaka, Martin L; Fischer, Kenneth J

2016-07-01

The design of products and processes is an important area in engineering. Students in engineering schools learn fundamental principles in their courses but often lack an opportunity to apply these methods to real-world problems until their senior year. This article describes important elements that should be incorporated into a senior capstone design course. It includes a description of the general principles used in engineering design and a discussion of why students often have difficulty with application and revert to trial and error methods. The structure of a properly designed capstone course is dissected and its individual components are evaluated. Major components include assessing resources, identifying projects, establishing teams, understanding requirements, developing conceptual designs, creating detailed designs, building prototypes, testing performance, and final presentations. In addition to the course design, team management and effective mentoring are critical to success. This article includes suggested guidelines and tips for effective design team leadership, attention to detail, investment of time, and managing project scope. Furthermore, the importance of understanding business culture, displaying professionalism, and considerations of different types of senior projects is discussed. Through a well-designed course and proper mentoring, students will learn to apply their engineering skills and gain basic business knowledge that will prepare them for entry-level positions in industry.

Calculation of odour emissions from aircraft engines at Copenhagen Airport.

PubMed

Winther, Morten; Kousgaard, Uffe; Oxbøl, Arne

2006-07-31

In a new approach the odour emissions from aircraft engines at Copenhagen Airport are calculated using actual fuel flow and emission measurements (one main engine and one APU: Auxiliary Power Unit), odour panel results, engine specific data and aircraft operational data for seven busy days. The calculation principle assumes a linear relation between odour and HC emissions. Using a digitalisation of the aircraft movements in the airport area, the results are depicted on grid maps, clearly reflecting aircraft operational statistics as single flights or total activity during a whole day. The results clearly reflect the short-term temporal fluctuations of the emissions of odour (and exhaust gases). Aircraft operating at low engine thrust (taxiing, queuing and landing) have a total odour emission share of almost 98%, whereas the shares for the take off/climb out phases (2%) and APU usage (0.5%) are only marginal. In most hours of the day, the largest odour emissions occur, when the total amount of fuel burned during idle is high. However, significantly higher HC emissions for one specific engine cause considerable amounts of odour emissions during limited time periods. The experimentally derived odour emission factor of 57 OU/mg HC is within the range of 23 and 110 OU/mg HC used in other airport odour studies. The distribution of odour emission results between aircraft operational phases also correspond very well with the results for these other studies. The present study uses measurement data for a representative engine. However, the uncertainties become large when the experimental data is used to estimate the odour emissions for all aircraft engines. More experimental data is needed to increase inventory accuracy, and in terms of completeness it is recommended to make odour emission estimates also for engine start and the fuelling of aircraft at Copenhagen Airport in the future.

Approximate similarity principle for a full-scale STOVL ejector

NASA Astrophysics Data System (ADS)

Barankiewicz, Wendy S.; Perusek, Gail P.; Ibrahim, Mounir B.

1994-03-01

Full-scale ejector experiments are expensive and difficult to implement at engine exhaust temperatures. For this reason the utility of using similarity principles, in particular the Munk and prim principle for isentropic flow, was explored. Static performance test data for a full-scale thrust augmenting ejector were analyzed for primary flow temperature up to 1560 R. At different primary temperatures, exit pressure contours were compared for similarity. A nondimensional flow parameter is then used to eliminate primary nozzle temperature dependence and verify similarity between the hot and cold flow experiments. Under the assumption that an appropriate similarity principle can be established, properly chosen performance parameters were found to be similar for both flow and cold flow model tests.

Opportunities and problems in introducing or expanding the teaching of remote sensing in universities

NASA Technical Reports Server (NTRS)

Maxwell, E. L.

1980-01-01

The need for degree programs in remote sensing is considered. Any education program which claims to train remote sensing specialists must include expertise in the physical principles upon which remote sensing is based. These principles dictate the limits of engineering and design, computer analysis, photogrammetry, and photointerpretation. Faculty members must be hired to provide emphasis in those five areas.

Engineering principles to assure compatible docking between future spacecraft of USA and USSR

NASA Technical Reports Server (NTRS)

Johnson, C. C.

1973-01-01

An androgynous peripheral type docking mechanism concept selected by the U.S. and the USSR is described. The rationale supporting the selection of the concept, the mechanical principles inherent to the concept, and the probable nature of future designs stemming from the concept are discussed. Operational situations prior to docking, impact conditions, energy absorption, and structural joining of two spacecraft are examined.

Introducing survival ethics into engineering education and practice.

PubMed

Verharen, C; Tharakan, J; Middendorf, G; Castro-Sitiriche, M; Kadoda, G

2013-06-01

Given the possibilities of synthetic biology, weapons of mass destruction and global climate change, humans may achieve the capacity globally to alter life. This crisis calls for an ethics that furnishes effective motives to take global action necessary for survival. We propose a research program for understanding why ethical principles change across time and culture. We also propose provisional motives and methods for reaching global consensus on engineering field ethics. Current interdisciplinary research in ethics, psychology, neuroscience and evolutionary theory grounds these proposals. Experimental ethics, the application of scientific principles to ethical studies, provides a model for developing policies to advance solutions. A growing literature proposes evolutionary explanations for moral development. Connecting these approaches necessitates an experimental or scientific ethics that deliberately examines theories of morality for reliability. To illustrate how such an approach works, we cover three areas. The first section analyzes cross-cultural ethical systems in light of evolutionary theory. While such research is in its early stages, its assumptions entail consequences for engineering education. The second section discusses Howard University and University of Puerto Rico/Mayagüez (UPRM) courses that bring ethicists together with scientists and engineers to unite ethical theory and practice. We include a syllabus for engineering and STEM (Science, Technology, Engineering and Mathematics) ethics courses and a checklist model for translating educational theory and practice into community action. The model is based on aviation, medicine and engineering practice. The third and concluding section illustrates Howard University and UPRM efforts to translate engineering educational theory into community action. Multidisciplinary teams of engineering students and instructors take their expertise from the classroom to global communities to examine further the ethicality of prospective technologies and the decision-making processes that lead to them.

Plant synthetic biology.

PubMed

Liu, Wusheng; Stewart, C Neal

2015-05-01

Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants. Copyright © 2015 Elsevier Ltd. All rights reserved.

A Concert between Biology and Biomechanics: The Influence of the Mechanical Environment on Bone Healing

PubMed Central

Glatt, Vaida; Evans, Christopher H.; Tetsworth, Kevin

2017-01-01

In order to achieve consistent and predictable fracture healing, a broad spectrum of growth factors are required to interact with one another in a highly organized response. Critically important, the mechanical environment around the fracture site will significantly influence the way bone heals, or if it heals at all. The role of the various biological factors, the timing, and spatial relationship of their introduction, and how the mechanical environment orchestrates this activity, are all crucial aspects to consider. This review will synthesize decades of work and the acquired knowledge that has been used to develop new treatments and technologies for the regeneration and healing of bone. Moreover, it will discuss the current state of the art in experimental and clinical studies concerning the application of these mechano-biological principles to enhance bone healing, by controlling the mechanical environment under which bone regeneration takes place. This includes everything from the basic principles of fracture healing, to the influence of mechanical forces on bone regeneration, and how this knowledge has influenced current clinical practice. Finally, it will examine the efforts now being made for the integration of this research together with the findings of complementary studies in biology, tissue engineering, and regenerative medicine. By bringing together these diverse disciplines in a cohesive manner, the potential exists to enhance fracture healing and ultimately improve clinical outcomes. PMID:28174539

Ferroelectricity in Ruddlesden-Popper Chalcogenide Perovskites for Photovoltaic Application: The Role of Tolerance Factor.

PubMed

Zhang, Yajun; Shimada, Takahiro; Kitamura, Takayuki; Wang, Jie

2017-12-07

Chalcogenide perovskites with optimal band gap and desirable light absorption are promising for photovoltaic devices, whereas the absence of ferroelectricity limits their potential in applications. On the basis of first-principles calculations, we reveal the underlying mechanism of the paraelectric nature of Ba 3 Zr 2 S 7 observed in experiments and demonstrate a general rule for the appearance of ferroelectricity in chalcogenide perovskites with Ruddlesden-Popper (RP) A 3 B 2 X 7 structures. Group theoretical analysis shows that the tolerance factor is the primary factor that dominates the ferroelectricity. Both Ba 3 Zr 2 S 7 and Ba 3 Hf 2 S 7 with large tolerance factor are paraelectric because of the suppression of in-phase rotation that is indispensable to hybrid improper ferroelectricity. In contrast, Ca 3 Zr 2 S 7 , Ca 3 Hf 2 S 7 , Ca 3 Zr 2 Se 7 , and Ca 3 Hf 2 S 7 with small tolerance factor exhibit in-phase rotation and can be stable in the ferroelectric Cmc2 1 ground state with nontrivial polarization. These findings not only provide useful guidance to engineering ferroelectricity in RP chalcogenide perovskites but also suggest potential ferroelectric semiconductors for photovoltaic applications.

The Process of Suicide Risk Assessment: Twelve Core Principles

ERIC Educational Resources Information Center

Granello, Darcy Haag

2010-01-01

Suicide risk assessment requires counselors to determine client risk factors, warning signs, and protective factors. The content of suicide assessment has received attention in the literature. The guiding principles of the process of suicide assessment, however, have not yet been articulated. This article contains 12 core process principles that…

Proceedings of the Annual Ada Software Engineering Education and Training Symposium (6th), Held in Alexandria, Virginia on September 11-13, 1991

DTIC Science & Technology

1991-09-01

level are, by necessity, designed to be accomplished by one or a few students in the course of a single academic term. Moreover, the software is seldom...that are covered in Computer Science curricula today, but with more of an engineering structure added. A stronger engineering design component is...ing, and sound software design principles found throughout Ada, and they are unambiguously specified. These are not features which were grafted onto a

Semiconductor nanocrystal quantum dot synthesis approaches towards large-scale industrial production for energy applications

DOE PAGES

Hu, Michael Z.; Zhu, Ting

2015-12-04

This study reviews the experimental synthesis and engineering developments that focused on various green approaches and large-scale process production routes for quantum dots. Fundamental process engineering principles were illustrated. In relation to the small-scale hot injection method, our discussions focus on the non-injection route that could be scaled up with engineering stir-tank reactors. In addition, applications that demand to utilize quantum dots as "commodity" chemicals are discussed, including solar cells and solid-state lightings.

Design for reliability: NASA reliability preferred practices for design and test

NASA Technical Reports Server (NTRS)

Lalli, Vincent R.

1994-01-01

This tutorial summarizes reliability experience from both NASA and industry and reflects engineering practices that support current and future civil space programs. These practices were collected from various NASA field centers and were reviewed by a committee of senior technical representatives from the participating centers (members are listed at the end). The material for this tutorial was taken from the publication issued by the NASA Reliability and Maintainability Steering Committee (NASA Reliability Preferred Practices for Design and Test. NASA TM-4322, 1991). Reliability must be an integral part of the systems engineering process. Although both disciplines must be weighed equally with other technical and programmatic demands, the application of sound reliability principles will be the key to the effectiveness and affordability of America's space program. Our space programs have shown that reliability efforts must focus on the design characteristics that affect the frequency of failure. Herein, we emphasize that these identified design characteristics must be controlled by applying conservative engineering principles.

Looking into the Earth

NASA Astrophysics Data System (ADS)

Mussett, Alan E.; Aftab Khan, M.; Button, Illustrated By Sue

2000-12-01

Looking Into the Earth comprehensively describes the principles and applications of both `global' and `exploration' geophysics on all scales. It forms an introduction to geophysics suitable for those who do not necessarily intend to become professional geophysicists, including geologists, civil engineers, environmental scientists, and field archaeologists. The book is organised into two parts: Part 1 describes the geophysical methods, while Part 2 illustrates their use in a number of extended case histories. Mathematical and physical principles are introduced at an elementary level, and then developed as necessary. Student questions and exercises are included at the end of each chapter. The book is aimed primarily at introductory and intermediate university students taking courses in geology, earth science, environmental science, and engineering. It will also form an excellent introductory textbook in geophysics departments, and will help practising geologists, archaeologists and engineers understand what geophysics can offer their work. Accessible to students with little background in maths and physics Covers both global and applied geophysics Well illustrated and contains many student exercises and case studies Written by experienced teachers of geophysics

Modern Management Principles Come to the Dental School.

PubMed

Wataha, John C; Mouradian, Wendy E; Slayton, Rebecca L; Sorensen, John A; Berg, Joel H

2016-04-01

The University of Washington School of Dentistry may be the first dental school in the nation to apply lean process management principles as a primary tool to re-engineer its operations and curriculum to produce the dentist of the future. The efficiencies realized through re-engineering will better enable the school to remain competitive and viable as a national leader of dental education. Several task forces conducted rigorous value stream analyses in a highly collaborative environment led by the dean of the school. The four areas undergoing evaluation and re-engineering were organizational infrastructure, organizational processes, curriculum, and clinic operations. The new educational model was derived by thoroughly analyzing the current state of dental education in order to design and achieve the closest possible ideal state. As well, the school's goal was to create a lean, sustainable operational model. This model aims to ensure continued excellence in restorative dental instruction and to serve as a blueprint for other public dental schools seeking financial stability in this era of shrinking state support and rising costs.

On extracting design principles from biology: I. Method-General answers to high-level design questions for bioinspired robots.

PubMed

Haberland, M; Kim, S

2015-02-02

When millions of years of evolution suggest a particular design solution, we may be tempted to abandon traditional design methods and copy the biological example. However, biological solutions do not often translate directly into the engineering domain, and even when they do, copying eliminates the opportunity to improve. A better approach is to extract design principles relevant to the task of interest, incorporate them in engineering designs, and vet these candidates against others. This paper presents the first general framework for determining whether biologically inspired relationships between design input variables and output objectives and constraints are applicable to a variety of engineering systems. Using optimization and statistics to generalize the results beyond a particular system, the framework overcomes shortcomings observed of ad hoc methods, particularly those used in the challenging study of legged locomotion. The utility of the framework is demonstrated in a case study of the relative running efficiency of rotary-kneed and telescoping-legged robots.

Huyghens Engines--a new concept and its embodiment for nano-micro interlevel information processing.

PubMed

Santoli, Salvatore

2009-02-01

Current criteria in Bionanotechnology based on software and sensor/actuator hardware of Artificial Intelligence for bioinspired nanostructured systems lack the nanophysical background and key mathematics to describe and mimick the biological hierarchies of nano-to-micro-integrated informational/energetic levels. It is argued that bionanoscale hardware/software undividable solidarity can be mimicked by artificial nanostructured systems featuring intra/interlevel information processing through the emerging organization principle of quantum holography, described by the Heisenberg group G and by harmonic analysis on G. From a property of G as a Lie group, quantum holography is shown to merge the quantum/classical dynamic-symbolic ongoings into the structure-function unity of biological sensing-information processing-actuating, while by Ch. Huyghens' principles about wave motion and coupled oscillators synchronization it applies to environmental waves of any kind, so embodying a universal information processing engine, dubbed Huyghens Engine, that mimicks the holistic nanobiological structure-function solidarity and the kinetics/thermodynamics of nano/micro interface information transfer.

Atomic-scale insight and design principles for turbine engine thermal barrier coatings from theory

PubMed Central

Marino, Kristen A.; Hinnemann, Berit; Carter, Emily A.

2011-01-01

To maximize energy efficiency, gas turbine engines used in airplanes and for power generation operate at very high temperatures, even above the melting point of the metal alloys from which they are comprised. This feat is accomplished in part via the deposition of a multilayer, multicomponent thermal barrier coating (TBC), which lasts up to approximately 40,000 h before failing. Understanding failure mechanisms can aid in designing circumvention strategies. We review results of quantum mechanics calculations used to test hypotheses about impurities that harm TBCs and transition metal (TM) additives that render TBCs more robust. In particular, we discovered a number of roles that Pt and early TMs such as Hf and Y additives play in extending the lifetime of TBCs. Fundamental insight into the nature of the bonding created by such additives and its effect on high-temperature evolution of the TBCs led to design principles that can be used to create materials for even more efficient engines.

The biomaterials conundrum in tissue engineering.

PubMed

Williams, David F

2014-04-01

The development of biomaterials for use in tissue engineering processes has not so far followed a scientifically valid pathway; there have been no properly constituted specifications for these biomaterials, whose choice has often been dictated by the perceived need to comply with prior FDA approval for use of the materials in nontissue engineering applications. This short essay discusses the difficulties that have resulted in this approach and provides both conceptual and practical solutions for the future, based on sound principles of biocompatibility and the need to use tissue engineering templates that replicate the niche of the target cells.

Creating to understand - developmental biology meets engineering in Paris.

PubMed

Kicheva, Anna; Rivron, Nicolas C

2017-03-01

In November 2016, developmental biologists, synthetic biologists and engineers gathered in Paris for a meeting called 'Engineering the embryo'. The participants shared an interest in exploring how synthetic systems can reveal new principles of embryonic development, and how the in vitro manipulation and modeling of development using stem cells can be used to integrate ideas and expertise from physics, developmental biology and tissue engineering. As we review here, the conference pinpointed some of the challenges arising at the intersection of these fields, along with great enthusiasm for finding new approaches and collaborations. © 2017. Published by The Company of Biologists Ltd.

The Principles of Engineering Immune Cells to Treat Cancer

PubMed Central

Lim, Wendell A.; June, Carl H.

2017-01-01

Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can serve as a powerful new class of cancer therapeutics. Clinical experience has helped to define the major challenges that must be met to make engineered T cells a reliable, safe, and effective platform that can be deployed against a broad range of tumors. The emergence of synthetic biology approaches for cellular engineering is providing us with a broadly expanded set of tools for programming immune cells. We discuss how these tools could be used to design the next generation of smart T cell precision therapeutics. PMID:28187291

Working on the Boundaries: Philosophies and Practices of the Design Process

NASA Technical Reports Server (NTRS)

Ryan, R.; Blair, J.; Townsend, J.; Verderaime, V.

1996-01-01

While systems engineering process is a program formal management technique and contractually binding, the design process is the informal practice of achieving the design project requirements throughout all design phases of the systems engineering process. The design process and organization are systems and component dependent. Informal reviews include technical information meetings and concurrent engineering sessions, and formal technical discipline reviews are conducted through the systems engineering process. This paper discusses and references major philosophical principles in the design process, identifies its role in interacting systems and disciplines analyses and integrations, and illustrates the process application in experienced aerostructural designs.

Finite Element Method (FEM), Mechanobiology and Biomimetic Scaffolds in Bone Tissue Engineering

PubMed Central

Boccaccio, A.; Ballini, A.; Pappalettere, C.; Tullo, D.; Cantore, S.; Desiate, A.

2011-01-01

Techniques of bone reconstructive surgery are largely based on conventional, non-cell-based therapies that rely on the use of durable materials from outside the patient's body. In contrast to conventional materials, bone tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences towards the development of biological substitutes that restore, maintain, or improve bone tissue function. Bone tissue engineering has led to great expectations for clinical surgery or various diseases that cannot be solved with traditional devices. For example, critical-sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of bone tissue engineering is to apply engineering principles to incite and promote the natural healing process of bone which does not occur in critical-sized defects. The total market for bone tissue regeneration and repair was valued at $1.1 billion in 2007 and is projected to increase to nearly $1.6 billion by 2014. Usually, temporary biomimetic scaffolds are utilized for accommodating cell growth and bone tissue genesis. The scaffold has to promote biological processes such as the production of extra-cellular matrix and vascularisation, furthermore the scaffold has to withstand the mechanical loads acting on it and to transfer them to the natural tissues located in the vicinity. The design of a scaffold for the guided regeneration of a bony tissue requires a multidisciplinary approach. Finite element method and mechanobiology can be used in an integrated approach to find the optimal parameters governing bone scaffold performance. In this paper, a review of the studies that through a combined use of finite element method and mechano-regulation algorithms described the possible patterns of tissue differentiation in biomimetic scaffolds for bone tissue engineering is given. Firstly, the generalities of the finite element method of structural analysis are outlined; second, the issues related to the generation of a finite element model of a given anatomical site or of a bone scaffold are discussed; thirdly, the principles on which mechanobiology is based, the principal theories as well as the main applications of mechano-regulation models in bone tissue engineering are described; finally, the limitations of the mechanobiological models and the future perspectives are indicated. PMID:21278921

Integrated two-cylinder liquid piston Stirling engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Ning; Rickard, Robert; Pluckter, Kevin

2014-10-06

Heat engines utilizing the Stirling cycle may run on low temperature differentials with the capacity to function at high efficiency due to their near-reversible operation. However, current approaches to building Stirling engines are laborious and costly. Typically the components are assembled by hand and additional components require a corresponding increase in manufacturing complexity, akin to electronics before the integrated circuit. We present a simple and integrated approach to fabricating Stirling engines with precisely designed cylinders. We utilize computer aided design and one-step, planar machining to form all components of the engine. The engine utilizes liquid pistons and displacers to harnessmore » useful work from heat absorption and rejection. As a proof of principle of the integrated design, a two-cylinder engine is produced and characterized and liquid pumping is demonstrated.« less

Electrochemical energy engineering: a new frontier of chemical engineering innovation.

PubMed

Gu, Shuang; Xu, Bingjun; Yan, Yushan

2014-01-01

One of the grand challenges facing humanity today is a safe, clean, and sustainable energy system where combustion no longer dominates. This review proposes that electrochemical energy conversion could set the foundation for such an energy system. It further suggests that a simple switch from an acid to a base membrane coupled with innovative cell designs may lead to a new era of affordable electrochemical devices, including fuel cells, electrolyzers, solar hydrogen generators, and redox flow batteries, for which recent progress is discussed using the authors' work as examples. It also notes that electrochemical energy engineering will likely become a vibrant subdiscipline of chemical engineering and a fertile ground for chemical engineering innovation. To realize this vision, it is necessary to incorporate fundamental electrochemistry and electrochemical engineering principles into the chemical engineering curriculum.

System analysis of a piston steam engine employing the uniflow principle, a study in optimized performance

NASA Technical Reports Server (NTRS)

Peoples, J. A.

1975-01-01

Results are reported which were obtained from a mathematical model of a generalized piston steam engine configuration employing the uniflow principal. The model accounted for the effects of clearance volume, compression work, and release volume. A simple solution is presented which characterizes optimum performance of the steam engine, based on miles per gallon. Development of the mathematical model is presented. The relationship between efficiency and miles per gallon is developed. An approach to steam car analysis and design is presented which has purpose rather than lucky hopefulness. A practical engine design is proposed which correlates to the definition of the type engine used. This engine integrates several system components into the engine structure. All conclusions relate to the classical Rankine Cycle.

Integrated two-cylinder liquid piston Stirling engine

NASA Astrophysics Data System (ADS)

Yang, Ning; Rickard, Robert; Pluckter, Kevin; Sulchek, Todd

2014-10-01

Heat engines utilizing the Stirling cycle may run on low temperature differentials with the capacity to function at high efficiency due to their near-reversible operation. However, current approaches to building Stirling engines are laborious and costly. Typically the components are assembled by hand and additional components require a corresponding increase in manufacturing complexity, akin to electronics before the integrated circuit. We present a simple and integrated approach to fabricating Stirling engines with precisely designed cylinders. We utilize computer aided design and one-step, planar machining to form all components of the engine. The engine utilizes liquid pistons and displacers to harness useful work from heat absorption and rejection. As a proof of principle of the integrated design, a two-cylinder engine is produced and characterized and liquid pumping is demonstrated.

Comprehensive Erosion and Sediment Control Training Program for Engineers, Architects and Planners.

ERIC Educational Resources Information Center

Porter, Harry L., Jr.

This program training text was designed to provide uniform instruction to the engineer, architect, planner, and others who will be helping to implement an erosion and sediment control program. Although tailored for use in Virginia, the basic principles covered are universal, and the material is adaptable to meet the needs in any State. The 11…

Novel Model-Based Inquiry of Ionic Bonding in Alginate Hydrogels Used in Tissue Engineering for High School Students

ERIC Educational Resources Information Center

Bowles, Robby D.; Saroka, James M.; Archer, Shivaun D.; Bonassar, Lawrence J.

2012-01-01

Because of cost and time, it is difficult to relate to students how fundamental chemical principles are involved in cutting edge biomedical breakthroughs being reported in the national media. The laboratory exercise presented here is aimed at high school chemistry students and uses alginate hydrogels, a common material used in tissue engineering,…

Electronic materials testing in commercial aircraft engines

NASA Astrophysics Data System (ADS)

Brand, Dieter

A device for the electronic testing of materials used in commercial aircraft engines is described. The instrument can be used for ferromagnetic, ferrimagnetic, and nonferromagnetic metallic materials, and it functions either optically or acoustically. The design of the device is described and technical data are given. The device operates under the principle of controlled self-inductivity. Its mode of operation is described.