Advanced Technical Data Study

DTIC Science & Technology

1975-01-29

will shut down automatically when condenser high pressure causes Pressure Limit Control high pressure switch to release. Press START switch (3...power cable (1) from facility pow- er. Troubleshoot cooling unit, for HI-LOW pressure switch repeated cutout. Refer to AGE ECU Cooling Unit...acti- vate when loss of air flow oc- curred, the pressure switch (3) failed to open circuit. Adjust or replace pressure switch . Refer to

Using dew points to estimate savings during a planned cooling shutdown

NASA Astrophysics Data System (ADS)

Friedlein, Matthew T.; Changnon, David; Musselman, Eric; Zielinski, Jeff

2005-12-01

In an effort to save money during the summer of 2003, Northern Illinois University (NIU) administrators instituted a four-day working week and stopped air conditioning buildings for the three-day weekends (Friday through Sunday). Shutting down the air conditioning systems caused a noticeable drop in electricity usage for that part of the campus that features in our study, with estimated total electricity savings of 1,268,492 kilowatt-hours or 17% of the average usage during that eight-week period. NIU's air conditioning systems, which relied on evaporative cooling to function, were sensitive to dew point levels. Greatest savings during the shutdown period occurred on days with higher dew points. An examination of the regional dew point climatology (1959 2003) indicated that the average summer daily dew point for 2003 was 14.9°C (58.8°F), which fell in the lowest 20% of the distribution. Based on the relationship between daily average dew points and electrical usage, a predictive model that could estimate electrical daily savings was created. This model suggests that electrical savings related to any future three-day shutdowns over summer could be much greater in more humid summers. Studies like this demonstrate the potential value of applying climatological information and of integrating this information into practical decision-making.

Save More Tomorrow: Using Behavioral Economics to Increase Employee Saving.

ERIC Educational Resources Information Center

Thaler, Richard H.; Benartzi, Shlomo

2004-01-01

As firms switch from defined-benefit plans to defined-contribution plans, employees bear more responsibility for making decisions about how much to save. The employees who fail to join the plan or who participate at a very low level appear to be saving at less than the predicted life cycle savings rates. Behavioral explanations for this behavior…

Method of locating a leaking fuel element in a fast breeder power reactor

DOEpatents

Honekamp, John R.; Fryer, Richard M.

1978-01-01

Leaking fuel elements in a fast reactor are identified by measuring the ratio of .sup.134 Xe to .sup.133 Xe in the reactor cover gas following detection of a fuel element leak, this ratio being indicative of the power and burnup of the failed fuel element. This procedure can be used to identify leaking fuel elements in a power breeder reactor while continuing operation of the reactor since the ratio measured is that of the gases stored in the plenum of the failed fuel element. Thus, use of a cleanup system for the cover gas makes it possible to identify sequentially a multiplicity of leaking fuel elements without shutting the reactor down.

Fault Detection and Isolation for Hydraulic Control

NASA Technical Reports Server (NTRS)

1987-01-01

Pressure sensors and isolation valves act to shut down defective servochannel. Redundant hydraulic system indirectly senses failure in any of its electrical control channels and mechanically isolates hydraulic channel controlled by faulty electrical channel so flat it cannot participate in operating system. With failure-detection and isolation technique, system can sustains two failed channels and still functions at full performance levels. Scheme useful on aircraft or other systems with hydraulic servovalves where failure cannot be tolerated.

Sandia, California Tritium Research Laboratory transition and reutilization project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia, T.B.

1997-02-01

This paper describes a project within Sandia National Laboratory to convert the shut down Tritium Research Laboratory into a facility which could be reused within the laboratory complex. In the process of decommissioning and decontaminating the facility, the laboratory was able to save substantial financial resources by transferring much existing equipment to other DOE facilities, and then expeditiously implementing a decontamination program which has resulted in the building being converted into laboratory space for new lab programs. This project of facility reuse has been a significant financial benefit to the laboratory.

Programs for Children with Specific Learning Disabilities. P.L. 91-230, Title VI-G. Final Report on Products and Results of Year's Work, July 1, 1973 to June 30, 1974. Fail Save Continuum.

ERIC Educational Resources Information Center

1974

Presented is the final report of the Learning Disability Fail-Save Continuum Project, designed to provide identification, assessment, and placement services to 378 elementary and secondary level students. Outlined in Section I are the following project components: major revisions from the original proposal (such as implementation of the itinerant…

Method and apparatus for in-cell vacuuming of radiologically contaminated materials

DOEpatents

Spadaro, Peter R.; Smith, Jay E.; Speer, Elmer L.; Cecconi, Arnold L.

1987-01-01

A vacuum air flow operated cyclone separator arrangement for collecting, handling and packaging loose contaminated material in accordance with acceptable radiological and criticality control requirements. The vacuum air flow system includes a specially designed fail-safe prefilter installed upstream of the vacuum air flow power supply. The fail-safe prefilter provides in-cell vacuum system flow visualization and automatically reduces or shuts off the vacuum air flow in the event of an upstream prefilter failure. The system is effective for collecting and handling highly contaminated radiological waste in the form of dust, dirt, fuel element fines, metal chips and similar loose material in accordance with radiological and criticality control requirements for disposal by means of shipment and burial.

Can regional climate engineering save the summer Arctic sea ice?

NASA Astrophysics Data System (ADS)

Tilmes, S.; Jahn, Alexandra; Kay, Jennifer E.; Holland, Marika; Lamarque, Jean-Francois

2014-02-01

Rapid declines in summer Arctic sea ice extent are projected under high-forcing future climate scenarios. Regional Arctic climate engineering has been suggested as an emergency strategy to save the sea ice. Model simulations of idealized regional dimming experiments compared to a business-as-usual greenhouse gas emission simulation demonstrate the importance of both local and remote feedback mechanisms to the surface energy budget in high latitudes. With increasing artificial reduction in incoming shortwave radiation, the positive surface albedo feedback from Arctic sea ice loss is reduced. However, changes in Arctic clouds and the strongly increasing northward heat transport both counteract the direct dimming effects. A 4 times stronger local reduction in solar radiation compared to a global experiment is required to preserve summer Arctic sea ice area. Even with regional Arctic dimming, a reduction in the strength of the oceanic meridional overturning circulation and a shut down of Labrador Sea deep convection are possible.

Design and Manufacture of Structurally Efficient Tapered Struts

NASA Technical Reports Server (NTRS)

Brewster, Jebediah W.

2009-01-01

Composite materials offer the potential of weight savings for numerous spacecraft and aircraft applications. A composite strut is just one integral part of the node-to-node system and the optimization of the shut and node assembly is needed to take full advantage of the benefit of composites materials. Lockheed Martin designed and manufactured a very light weight one piece composite tapered strut that is fully representative of a full scale flight article. In addition, the team designed and built a prototype of the node and end fitting system that will effectively integrate and work with the full scale flight articles.

Using Culture to Explain Behavior: An Integrative Cultural Approach

ERIC Educational Resources Information Center

Shepherd, Hana R.; Stephens, Nicole M.

2010-01-01

While savings rates among low-income families vary greatly, a 2008 National Poverty Center report finds that over 40 percent of low-income families fail to save any money. For decades policy makers and social scientists have sought to explain this phenomenon. Even after accounting for the fact that low-income families have less money to save, why…

Advanced Health Management of a Brushless Direct Current Motor/Controller

NASA Technical Reports Server (NTRS)

Pickett, R. D.

2003-01-01

This effort demonstrates that health management can be taken to the component level for electromechanical systems. The same techniques can be applied to take any health management system to the component level, based on the practicality of the implementation for that particular system. This effort allows various logic schemes to be implemented for the identification and management of failures. By taking health management to the component level, integrated vehicle health management systems can be enhanced by protecting box-level avionics from being shut down in order to isolate a failed computer.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankamo, T.; Kim, I.S.; Yang, Ji Wu

Failures in the auxiliary feedwater (AFW) system of pressurized water reactors (PWRs) are considered to involve substantial risk whether a decision is made to either continue power operation while repair is being done, or to shut down the plant to undertake repairs. Technical specification action requirements usually require immediate plant shutdown in the case of multiple failures in the system (in some cases, immediate repair of one train is required when all AFW trains fail). This paper presents a probabilistic risk assessment-based method to quantitatively evaluate and compare both the risks of continued power operation and of shutting the plantmore » down, given known failures in the system. The method is applied to the AFW system for four different PWRs. Results show that the risk of continued power operation and plant shutdown both are substantial, but the latter is larger than the former over the usual repair time. This was proven for four plants with different designs: two operating Westinghouse plants, one operating Asea-Brown Boveri Combustion Engineering Plant, and one of evolutionary design. The method can be used to analyze individual plant design and to improve AFW action requirements using risk-informed evaluations.« less

An A-76 Survival Guide

DTIC Science & Technology

2002-04-09

25 THE SAVINGS BUGABOO ...fail to capture some important costs, particularly initial investment costs to conduct the competition and implement the contract or MEO (e.g...would be well spent as current employees are aware that the government continues to look at outsourcing more functions. CONCLUSION THE SAVINGS BUGABOO

Why Save Wilderness?--Fruits and Veggies!

ERIC Educational Resources Information Center

Kowalewski, David

2015-01-01

Why save wilderness? Environmental educators usually offer ecosystemic and aesthetic reasons, yet clearly this abstract approach has failed to resonate with the wider public. In this article I adopt a nutritional strategy based on a broad array of sources. Wild plant food, in terms of economics, ubiquity, and other measures, performs very well…

Assessing Potential Energy Cost Savings from Increased Energy Code Compliance in Commercial Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenberg, Michael I.; Hart, Philip R.; Athalye, Rahul A.

The US Department of Energy’s most recent commercial energy code compliance evaluation efforts focused on determining a percent compliance rating for states to help them meet requirements under the American Recovery and Reinvestment Act (ARRA) of 2009. That approach included a checklist of code requirements, each of which was graded pass or fail. Percent compliance for any given building was simply the percent of individual requirements that passed. With its binary approach to compliance determination, the previous methodology failed to answer some important questions. In particular, how much energy cost could be saved by better compliance with the commercial energymore » code and what are the relative priorities of code requirements from an energy cost savings perspective? This paper explores an analytical approach and pilot study using a single building type and climate zone to answer those questions.« less

Power-Factor Controllers: How Safe?

NASA Technical Reports Server (NTRS)

Long, K.; Christian, W.; Kovacik, J.; Grazyk, T.

1985-01-01

Potential safety problems with power-factor controllers (PFC's) evaluated. Based on study of PFCs in use with appliances, report recommends measures to prevent consumers from misapplying these energy saving devices. Device used on such appliances as refrigerators, sewing machines, pumps, hair dryers, and food processors. When misused, they fail to save energy and may cause damage.

The Art of Saving a Failing School

ERIC Educational Resources Information Center

Stein, Les

2012-01-01

While the debate continues over whether to close failing schools or attempt fixing them, the author asserts that the solution most often lies in assigning strong leaders to them who will take definite and immediate action. Reviewing his own success turning around schools, he says creating a sense of urgency, unloading poor performing staff, and…

Methods and Devices for Modifying Active Paths in a K-Delta-1-Sigma Modulator

NASA Technical Reports Server (NTRS)

Ardalan, Sasan (Inventor)

2017-01-01

The invention relates to an improved K-Delta-1-Sigma Modulators (KG1Ss) that achieve multi GHz sampling rates with 90 nm and 45 nm CMOS processes, and that provide the capability to balance performance with power in many applications. The improved KD1Ss activate all paths when high performance is needed (e.g. high bandwidth), and reduce the effective bandwidth by shutting down multiple paths when low performance is required. The improved KD1Ss can adjust the baseband filtering for lower bandwidth, and can provide large savings in power consumption while maintaining the communication link, which is a great advantage in space communications. The improved KD1Ss herein provides a receiver that adjusts to accommodate a higher rate when a packet is received at a low bandwidth, and at a initial lower rate, power is saved by turning off paths in the KD1S Analog to Digital Converter, and where when a higher rate is required, multiple paths are enabled in the KD1S to accommodate the higher band widths.

Application of MODFLOW for oil reservoir simulation during the Deepwater Horizon Crisis

USGS Publications Warehouse

Hsieh, Paul A.

2011-01-01

When the Macondo well was shut in on July 15, 2010, the shut-in pressure recovered to a level that indicated the possibility of oil leakage out of the well casing into the surrounding formation. Such a leak could initiate a hydraulic fracture that might eventually breach the seafloor, resulting in renewed and uncontrolled oil flow into the Gulf of Mexico. To help evaluate whether or not to reopen the well, a MODFLOW model was constructed within 24 h after shut in to analyze the shut-in pressure. The model showed that the shut-in pressure can be explained by a reasonable scenario in which the well did not leak after shut in. The rapid response provided a scientific analysis for the decision to keep the well shut, thus ending the oil spill resulting from the Deepwater Horizon blow out.

When energy saving advice leads to more, rather than less, consumption

NASA Astrophysics Data System (ADS)

Revell, Kirsten M. A.; Stanton, Neville A.

2017-01-01

Energy saving technology that relies on behaviour change fails to deliver on its promise. Energy saving advice also has limited effect. This paper examines and reveals how technology and energy saving advice interacts with householders' thought processes to influence energy consumption. A case study of three households that held a 'Feedback' mental model of the home heating thermostat, as defined by Kempton [1986. 'Two Theories of Home Heat Control'. Cognitive Science 10 (1): 75-90], was undertaken to understand the driver behind differences in their home heating strategies, and the effect on energy consumption. Analysis was undertaken from five different data sources comprising: (1) boiler on durations, (2) thermostat set point adjustments, (3) self-reported strategies with home heating controls, (4) user mental model descriptions of the home heating system, and (5) Interview transcripts. The authors found that differences in user mental models of home heating at the system level explained differences in the strategies chosen at the control device level. Differences in boiler on periods were found to relate to limitations of the 'Feedback' mental model; that is, the model fails to consider the effect of the movement of warm air within the home and the impact of internal/external temperature differentials on heat loss rates. The authors argue that technology and advice should be tailored to the thought processes adopted by householders in order to promote behaviour that would realise intended energy savings.

What is Swanson's Law & why Should you Care?

NASA Astrophysics Data System (ADS)

Hansen, S. F.; Partain, L.; Hansen, R. T.

2015-12-01

For 40 years the cost of Solar Photovoltaics (PV) has decreased by a factor of 2 for every 10X increase in its cumulative-installed electric-generating capacity (CC). The straight line, log-log, experimental and historical data fit of cost versus CC is called Swanson's Law for its accurate fit of the rapid decrease in cost over 6 orders of magnitude increase in CC with time. Now Solar PV is cost competitive with coal and natural gas in some regions and provides 1% of the world's electric generating capacity. The Law can next be tested to predict the future. With 2 more orders of magnitude increase in CC, Solar PV could provide 10% and then 100% of the world's current electric capacity, as the Law projects costs falling by another factor of 4. For the last 10 years CC has doubled every 2 years under strong public policy support. If this doubling and policy support are extended, an order-of-magnitude increase (10X) will occur every 6.6 yrs and installed solar PV capacity could reach 100% of the current world's consumption in 13 years or by 2028. The world's solar resource, accessible indefinitely and yearly to PV, is over 1000 times current consumption while coal, uranium, petroleum and natural gas are finite, limited resources, destined to be depleted within our lifetimes or the lives of our children or grandchildren. In 2015 a 56 MW fossil fueled power plant was shut down at Stanford University and replaced with Solar PV and geothermal to save money and eliminate greenhouse gas emissions. If more such shut downs could follow this same 2 year doubling time as Solar PV, then the replacements could exceed 14,000 within 26 years or by 2041, including all 7000 current coal-fired plants plus an equivalent number fueled by uranium, petroleum and natural gas. These shut-downs, including all current fossil-fueled-power plants, could start reversing the human-generated, greenhouse-gas-induced, global climate changes by 2041.

Saving Now and Saving Later: How High School Reform Can Reduce the Nation's Wasted Remediation Dollars. Issue Brief

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2011

2011-01-01

For young people entering the twenty-first-century job market, high school graduation is no longer the finish line, but the starting line. While one-third of students will fail to graduate from high school, too many students who do graduate and make it to the postsecondary starting line find that they are underprepared for postsecondary work. A…

46 CFR 58.05-10 - Automatic shut-off.

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND RELATED SYSTEMS Main Propulsion Machinery § 58.05-10 Automatic shut-off. Main propulsion machinery... controls must shut down main propulsion machinery in case of a failure, such as failure of the lubricating...

46 CFR 58.05-10 - Automatic shut-off.

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND RELATED SYSTEMS Main Propulsion Machinery § 58.05-10 Automatic shut-off. Main propulsion machinery... controls must shut down main propulsion machinery in case of a failure, such as failure of the lubricating...

46 CFR 58.05-10 - Automatic shut-off.

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND RELATED SYSTEMS Main Propulsion Machinery § 58.05-10 Automatic shut-off. Main propulsion machinery... controls must shut down main propulsion machinery in case of a failure, such as failure of the lubricating...

46 CFR 58.05-10 - Automatic shut-off.

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND RELATED SYSTEMS Main Propulsion Machinery § 58.05-10 Automatic shut-off. Main propulsion machinery... controls must shut down main propulsion machinery in case of a failure, such as failure of the lubricating...

46 CFR 58.05-10 - Automatic shut-off.

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND RELATED SYSTEMS Main Propulsion Machinery § 58.05-10 Automatic shut-off. Main propulsion machinery... controls must shut down main propulsion machinery in case of a failure, such as failure of the lubricating...

Similarities and Differences in Patterns and Geolocation of SSH Attack Data

DTIC Science & Technology

2015-09-01

failed inputs. ..................................................................................14  Figure 7.  Latest “ passwd ” commands entered by...also has fake file contents to allow an attacker to “cat” files like /etc/ passwd [12]. Kippo saves all downloaded files for later inspection. The...overall post-compromise activity, human activity inside the honeypot, top 10 inputs (overall), top 10 successful inputs, top 10 failed inputs, passwd

'No power' (green) electrowetting display

NASA Astrophysics Data System (ADS)

Jentsch, Michael; Rawert, Juergen; Jerosch, Dieter; Blankenbach, Karlheinz

2011-05-01

Electrowetting displays were first reported in 1981, several approaches were examined. However, ADT's "Droplet- Driven-Displays" technology is the only bistable one which makes them very attractive for energy-saving systems. That means that the power supply can completely shut off after changing the content and it will keep its information for years. More features that make the ADT approach very unique are paper like white appearance (even in the powerless OFFstate) and the capability for backlighting (most of the other e-paper technologies like electrophoretics can not be backlighted). Further achievements are a white state reflectance of about 70% resulting in sunlight readability and a pixel size in the range from 0.3mm to 10mm. Summarizing, ADT's electrowetting technology is highly suitable for lowest power (means eco-friendly or "green") displays.

Cloud field classification based upon high spatial resolution textural features. II - Simplified vector approaches

NASA Technical Reports Server (NTRS)

Chen, D. W.; Sengupta, S. K.; Welch, R. M.

1989-01-01

This paper compares the results of cloud-field classification derived from two simplified vector approaches, the Sum and Difference Histogram (SADH) and the Gray Level Difference Vector (GLDV), with the results produced by the Gray Level Cooccurrence Matrix (GLCM) approach described by Welch et al. (1988). It is shown that the SADH method produces accuracies equivalent to those obtained using the GLCM method, while the GLDV method fails to resolve error clusters. Compared to the GLCM method, the SADH method leads to a 31 percent saving in run time and a 50 percent saving in storage requirements, while the GLVD approach leads to a 40 percent saving in run time and an 87 percent saving in storage requirements.

Water withdrawal and consumption reduction analysis for electrical energy generation system

NASA Astrophysics Data System (ADS)

Nouri, Narjes

There is an increasing concern over shrinking water resources. Water use in the energy sector primarily occurs in electricity generation. Anticipating scarcer supplies, the value of water is undoubtedly on the rise and design, implementation, and utilization of water saving mechanisms in energy generation systems are becoming inevitable. Most power plants generate power by boiling water to produce steam to spin electricity-generating turbines. Large quantities of water are often used to cool the steam in these plants. As a consequence, most fossil-based power plants in addition to consuming water, impact the water resources by raising the temperature of water withdrawn for cooling. A comprehensive study is conducted in this thesis to analyze and quantify water withdrawals and consumption of various electricity generation sources such as coal, natural gas, renewable sources, etc. Electricity generation for the state of California is studied and presented as California is facing a serious drought problem affecting more than 30 million people. Integrated planning for the interleaved energy and water sectors is essential for both water and energy savings. A linear model is developed to minimize the water consumption while considering several limitations and restrictions. California has planned to shut down some of its hydro and nuclear plants due to environmental concerns. Studies have been performed for various electricity generation and water saving scenarios including no-hydro and no-nuclear plant and the results are presented. Modifications to proposed different scenarios have been applied and discussed to meet the practical and reliability constraints.

Time-saving and fail-safe dissection method for vestibulocochlear organs in gross anatomy classes.

PubMed

Suzuki, Ryoji; Konno, Naoaki; Ishizawa, Akimitsu; Kanatsu, Yoshinori; Funakoshi, Kodai; Akashi, Hideo; Zhou, Ming; Abe, Hiroshi

2017-09-01

Because the vestibulocochlear organs are tiny and complex, and are covered by the petrous part of the temporal bone, they are very difficult for medical students to dissect and visualize during gross anatomy classes. Here, we report a time-saving and fail-safe procedure we have devised, using a hand-held hobby router. Nine en bloc temporal bone samples from donated human cadavers were used as trial materials for devising an appropriate procedure for dissecting the vestibulocochlear organs. A hand-held hobby router was used to cut through the temporal bone. After trials, the most time-saving and fail-safe method was selected. The performance of the selected method was assessed by a survey of 242 sides of 121 cadavers during gross anatomy classes for vestibulocochlear dissection. The assessment was based on the observation ratio. The best procedure appeared to be removal of the external acoustic meatus roof and tympanic cavity roof together with removal of the internal acoustic meatus roof. The whole procedure was completed within two dissection classes, each lasting 4.5 hr. The ratio of surveillance for the chorda tympani and three semicircular canals by students was significantly improved during 2013 through 2016. In our dissection class, "removal of the external acoustic meatus roof and tympanic cavity roof together with removal of the internal acoustic meatus roof" was the best procedure for students in the limited time available. Clin. Anat. 30:703-710, 2017. © 2017Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Satellite failures revisited

NASA Astrophysics Data System (ADS)

Balcerak, Ernie

2012-12-01

In January 1994, the two geostationary satellites known as Anik-E1 and Anik-E2, operated by Telesat Canada, failed one after the other within 9 hours, leaving many northern Canadian communities without television and data services. The outage, which shut down much of the country's broadcast television for hours and cost Telesat Canada more than $15 million, generated significant media attention. Lam et al. used publicly available records to revisit the event; they looked at failure details, media coverage, recovery effort, and cost. They also used satellite and ground data to determine the precise causes of those satellite failures. The researchers traced the entire space weather event from conditions on the Sun through the interplanetary medium to the particle environment in geostationary orbit.

Module failure isolation circuit for paralleled inverters. [preventing system failure during power conditioning for spacecraft applications

NASA Technical Reports Server (NTRS)

Nagano, S. (Inventor)

1979-01-01

A module failure isolation circuit is described which senses and averages the collector current of each paralled inverter power transistor and compares the collector current of each power transistor the average collector current of all power transistors to determine when the sensed collector current of a power transistor in any one inverter falls below a predetermined ratio of the average collector current. The module associated with any transistor that fails to maintain a current level above the predetermined radio of the average collector current is then shut off. A separate circuit detects when there is no load, or a light load, to inhibit operation of the isolation circuit during no load or light load conditions.

Suppressing active replication of a live attenuated simian immunodeficiency virus vaccine does not abrogate protection from challenge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gabriel, Benjamin; Fiebig, Uwe; Hohn, Oliver

Although safety concerns preclude the use of live attenuated HIV vaccines in humans, they provide a useful system for identifying the elusive correlates of protective immunity in the SIV/macaque animal model. However, a number of pieces of evidence suggest that protection may result from prior occupancy of susceptible target cells by the vaccine virus rather than the immune response. To address this, we developed a Nef-deletion variant of an RT-SHIV whose active replication could be shut off by treatment with RT-inhibitors. Groups of macaques were inoculated with the ∆Nef-RT-SHIV and immune responses allowed to develop before antiretroviral treatment and subsequentmore » challenge with wild-type SIVmac239. Vaccinated animals either resisted infection fully or significantly controlled the subsequent viremia. However, there was no difference between animals undergoing replication of the vaccine virus and those without. This strongly suggests that competition for available target cells does not play a role in protection. - Highlights: • A Nef-deleted RT-SHIV was used as a live attenuated vaccine in macaques. • Vaccine virus replication was shut down to investigate its role in protection. • Ongoing vaccine virus replication did not appear to be necessary for protection. • An analysis of T- and B-cell responses failed to identify a correlate of protection.« less

75 FR 7557 - Airworthiness Directives; The Boeing Company Model 767 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... shorts in many systems, including the spar fuel shut off valve, oxygen mask deployment, and burned wires... and wire bundles, causing shorts in many systems, including the spar fuel shut off valve, oxygen mask... and wire bundles, causing shorts in many systems, including the spar fuel shut off valve, oxygen mask...

Concept for a power system controller for large space electrical power systems

NASA Technical Reports Server (NTRS)

Lollar, L. F.; Lanier, J. R., Jr.; Graves, J. R.

1981-01-01

The development of technology for a fail-operatonal power system controller (PSC) utilizing microprocessor technology for managing the distribution and power processor subsystems of a large multi-kW space electrical power system is discussed. The specific functions which must be performed by the PSC, the best microprocessor available to do the job, and the feasibility, cost savings, and applications of a PSC were determined. A limited function breadboard version of a PSC was developed to demonstrate the concept and potential cost savings.

When All Else Fails, Organize and Advocate

ERIC Educational Resources Information Center

Prichard, Ami

2014-01-01

Caught in the perfect storm of a sour economy, declining home values, legislative tax hesitance, and growing unfunded mandates, a school district leads a campaign to raise local tax and bond levies to save jobs and enhance education.

New Understanding of Hubble Space Telescope Gyro Current Increase Led to a Method to Save a Failing Gyro Presentation

NASA Technical Reports Server (NTRS)

Blumenstock, Kenneth A.

2017-01-01

Throughout the history of the Hubble Space Telescope (HST) program, gyro current increases have been observed to occur, often times leading to gyro failure. The explanation was that debris from the surfaces of the gas bearings, with only 1.27 micron clearance, resulted in rotor restriction, which increased friction, torque, and current. However, the rotor restriction theory never could account for the fact that a restart of the gyro would restore the current back to nominal. An effort was made to understand this puzzling gyro behavior after two HST gyros exhibited increased current within the same week in November 2015. A review board was created to resolve these anomalies and generate operational procedures to potentially extend gyro life. A new understanding of gyro current behavior led to implementation of a method that could potentially save a failing gyro.

46 CFR 154.540 - Quick-closing shut-off valves: Emergency shut-down system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design... emergency shut-down system that: (a) Closes all the valves; (b) Is actuated by a single control in at least two locations remote from the quick-closing valves; (c) Is actuated by a single control in each cargo...

46 CFR 154.540 - Quick-closing shut-off valves: Emergency shut-down system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design... emergency shut-down system that: (a) Closes all the valves; (b) Is actuated by a single control in at least two locations remote from the quick-closing valves; (c) Is actuated by a single control in each cargo...

Energy Star program benefits Con Edison

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Impressed with savings in energy costs achieved after upgrading the lighting and air conditioning systems at its Manhattan headquarters, Home Box Office (HBO) wanted to do more, James Flock, vice president for computer and office systems, contacted Con Edison Co. of New York in March 1991 to determine what the company could do to save money by reducing energy consumed by personal computers. Arthur Kressner, Con Edison Research and Development manager contacted industry organizations and manufacturers for advice, but was told only to shut off computers at night and on weekends. Kressner arranged a series of meetings with IBM andmore » the Electric Power Research Institute (EPRI) to discuss the issue, then approached the U.S. Environmental Protection Agency (EPA), which was designing a program to promote the introduction and use of energy-efficient office equipment. In 1992, the EPA announced the Energy Star program for PCs, enabling manufacturers to display the Energy Star logo on machines meeting program criteria, including the ability to enter a sleep mode in which neither the computer nor monitor consume more than 30 W or electricity. Industry experts estimate national energy consumption by office equipment could double by the year 2000, but Energy Star equipment is expected to improve efficiency and help maintain electric loads.« less

75 FR 10696 - Airworthiness Directives; Fokker Services B.V. Model F.28 Mark 0070 and 0100 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... form on actuators P/N 9409122 installed on fuel crossfeed valves and fuel fire shut-off valves. Tests... fuel crossfeed valves and fuel fire shut-off valves. Tests revealed that the ice can prevent the... Tests for Fuel Crossfeed Valves and Fuel Fire Shut-Off Valves (g) For airplanes with an actuator having...

UVC Sheds New Light on School Mold Problems.

ERIC Educational Resources Information Center

Freeman, James

2002-01-01

Describes how the LaPorte Independent School District in Texas turned to ultraviolent light devices installed within the HVAC system to combat mold and fungus after conventional approaches failed. Describes the additional benefits of energy savings from the system. (EV)

Tornado wind-loading requirements based on risk assessment techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deobald, T.L.; Coles, G.A.; Smith, G.L.

Regulations require that nuclear power plants be protected from tornado winds. If struck by a tornado, a plant must be capable of safely shutting down and removing decay heat. Probabilistic techniques are used to show that risk to the public from the US Department of Energy (DOE) SP-100 reactor is acceptable without tornado hardening parts of the secondary system. Relaxed requirements for design wind loadings will result in significant cost savings. To demonstrate an acceptable level of risk, this document examines tornado-initiated accidents. The two tornado-initiated accidents examined in detail are loss of cooling resulting in core damage and lossmore » of secondary system boundary integrity leading to sodium release. Loss of core cooling is analyzed using fault/event tree models. Loss of secondary system boundary integrity is analyzed by comparing the consequences to acceptance criteria for the release of radioactive material or alkali metal aerosol. 4 refs., 4 figs.« less

Hybrid Vehicle Technologies and their potential for reducing oil use

NASA Astrophysics Data System (ADS)

German, John

2006-04-01

Vehicles with hybrid gasoline-electric powertrains are starting to gain market share. Current hybrid vehicles add an electric motor, battery pack, and power electronics to the conventional powertrain. A variety of engine/motor configurations are possible, each with advantages and disadvantages. In general, efficiency is improved due to engine shut-off at idle, capture of energy during deceleration that is normally lost as heat in the brakes, downsizing of the conventional engine, and, in some cases, propulsion on the electric motor alone. Ongoing increases in hybrid market share are dependent on cost reduction, especially the battery pack, efficiency synergies with other vehicle technologies, use of the high electric power to provide features desired by customers, and future fuel price and availability. Potential barriers include historically low fuel prices, high discounting of the fuel savings by new vehicle purchasers, competing technologies, and tradeoffs with other factors desired by customers, such as performance, utility, safety, and luxury features.

Volatile Organic Analyzer (VOA) in 2006: Repair, Revalidation, and Restart of Elektron Event

NASA Technical Reports Server (NTRS)

Limero, Thomas

2007-01-01

The Volatile Organic Analyzer (VOA) was launched to the International Space Station (ISS) in August 2001 and was the first instrument to provide near real-time measurement of volatile organic compounds in a spacecraft atmosphere. The VOA performed an analysis of the ISS air approximately twice a month for most of its operation through May 2003. This intermittent operation, caused by a software interface issue with the ISS communication bus, slowed the validation of the VOA. However, operational validation was completed in 2003 when analysis of air samples collected in grab sample containers (GSCs) compared favorably with simultaneous VOA runs (1). The VOA has two channels that provide redundant function, albeit at slightly reduced performance, when only one channel is operating (2). Most target compounds can be detected on both channels. In January 2003, the VOA identified a malfunction in the channel 2 preconcentrator and it shut down that channel. The anomaly profile suggested that a fuse might have failed, but the root cause could not be determined. In May 2003, channel 1 was shut down when the detector s elevated temperature could not longer be maintained. Since both VOA channels were now deactivated, VOA operations ended until an in-flight repair could be planned and executed. This paper describes the process to repair the VOA and to revalidate it for operations, and then an account is given of the VOA s contribution following a contingency event on ISS.

Scientific basis for safely shutting in the Macondo Well after the April 20, 2010 Deepwater Horizon blowout

USGS Publications Warehouse

Hickman, Stephen H.; Hsieh, Paul A.; Mooney, Walter D.; Enomoto, Catherine B.; Nelson, Philip H.; Flemings, Peter; Mayer, Larry; Moran, Kathryn; Weber, Thomas; McNutt, Marcia K.; Rice, James R.

2012-01-01

As part of the government response to the Deepwater Horizon blowout, a Well Integrity Team evaluated the geologic hazards of shutting in the Macondo Well at the seafloor and determined the conditions under which it could safely be undertaken. Of particular concern was the possibility that, under the anticipated high shut-in pressures, oil could leak out of the well casing below the seafloor. Such a leak could lead to new geologic pathways for hydrocarbon release to the Gulf of Mexico. Evaluating this hazard required analyses of 2D and 3D seismic surveys, seafloor bathymetry, sediment properties, geophysical well logs, and drilling data to assess the geological, hydrological, and geomechanical conditions around the Macondo Well. After the well was successfully capped and shut in on July 15, 2010, a variety of monitoring activities were used to assess subsurface well integrity. These activities included acquisition of wellhead pressure data, marine multichannel seismic profiles, seafloor and water-column sonar surveys, and wellhead visual/acoustic monitoring. These data showed that the Macondo Well was not leaking after shut in, and therefore, it could remain safely shut until reservoir pressures were suppressed (killed) with heavy drilling mud and the well was sealed with cement.

Rocky Mountain spotted fever: a clinician's dilemma.

PubMed

Masters, Edwin J; Olson, Gary S; Weiner, Scott J; Paddock, Christopher D

2003-04-14

Rocky Mountain spotted fever is still the most lethal tick-vectored illness in the United States. We examine the dilemmas facing the clinician who is evaluating the patient with possible Rocky Mountain spotted fever, with particular attention to the following 8 pitfalls in diagnosis and treatment: (1) waiting for a petechial rash to develop before diagnosis; (2) misdiagnosing as gastroenteritis; (3) discounting a diagnosis when there is no history of a tick bite; (4) using an inappropriate geographic exclusion; (5) using an inappropriate seasonal exclusion; (6) failing to treat on clinical suspicion; (7) failing to elicit an appropriate history; and (8) failing to treat with doxycycline. Early diagnosis and proper treatment save lives.

Structural health monitoring of wind turbine blades

NASA Astrophysics Data System (ADS)

Rumsey, Mark A.; Paquette, Joshua A.

2008-03-01

As electric utility wind turbines increase in size, and correspondingly, increase in initial capital investment cost, there is an increasing need to monitor the health of the structure. Acquiring an early indication of structural or mechanical problems allows operators to better plan for maintenance, possibly operate the machine in a de-rated condition rather than taking the unit off-line, or in the case of an emergency, shut the machine down to avoid further damage. This paper describes several promising structural health monitoring (SHM) techniques that were recently exercised during a fatigue test of a 9 meter glass-epoxy and carbon-epoxy wind turbine blade. The SHM systems were implemented by teams from NASA Kennedy Space Center, Purdue University and Virginia Tech. A commercial off-the-shelf acoustic emission (AE) NDT system gathered blade AE data throughout the test. At a fatigue load cycle rate around 1.2 Hertz, and after more than 4,000,000 fatigue cycles, the blade was diagnostically and visibly failing at the out-board blade spar-cap termination point at 4.5 meters. For safety reasons, the test was stopped just before the blade completely failed. This paper provides an overview of the SHM and NDT system setups and some current test results.

Interstate Electrification Improvement Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puckette, Margaret; Kim, Jeff

The Interstate Electrification Improvement Project, publicly known as the Shorepower Truck Electrification Project (STEP), started in May 2011 and ended in March 2015. The project grant was awarded by the Department of Energy’s Vehicles Technology Office in the amount of $22.2 million. It had three overarching missions: 1. Reduce the idling of Class 8 tractors when parked at truck stops, to reduce diesel fuel consumption and thus U.S. dependence on foreign petroleum; 2. Stimulate job creation and economic activity as part of the American Reinvestment and Recovery Act of 2009; 3. Reduce greenhouse gas emissions (GHG) from diesel combustion andmore » the carbon footprint of the truck transportation industry. The project design was straightforward. First, build fifty Truck Stop Electrification (TSE) facilities in truck stop parking lots across the country so trucks could plug-in to 110V, 220V, or 480VAC, and shut down the engine instead of idling. These facilities were strategically located at fifty truck stops along major U.S. Interstates with heavy truck traffic. Approximately 1,350 connection points were installed, including 150 high-voltage electric standby Transport Refrigeration Unit (eTRU) plugs--eTRUs are capable of plugging in to shore power1 to cool the refrigerated trailer for loads such as produce, meats and ice cream. Second, the project provided financial incentives on idle reduction equipment to 5,000 trucks in the form of rebates, to install equipment compatible with shore power. This equipment enables drivers to shut down the main engine when parked, to heat or cool their cab, charge batteries, or use other household appliances without idling—a common practice that uses approximately 1 gallon of diesel per hour. The rebate recipients were intended to be the first fleets to plug into Shorepower to save diesel fuel and ensure there is significant population of shore power capable trucks. This two part project was designed to complement each other by providing: 1) the infrastructure to plug into and 2) the on-board equipment capable of plugging into the infrastructure. This project generated the largest dataset to date on shore power TSE utilization and use patterns, providing: insight into driver behavior and acceptance; evidence of cost savings; experience with system operations and management; and data for guiding future development of shore power, whether as a private enterprise or a publicly-subsidized service for meeting air quality goals.« less

Semuloparin for prevention of venous thromboembolism after major orthopedic surgery: results from three randomized clinical trials, SAVE-HIP1, SAVE-HIP2 and SAVE-KNEE.

PubMed

Lassen, M R; Fisher, W; Mouret, P; Agnelli, G; George, D; Kakkar, A; Mismetti, P; Turpie, A G G

2012-05-01

Semuloparin is a novel ultra-low-molecular-weight heparin under development for venous thromboembolism (VTE) prevention in patients at increased risk, such as surgical and cancer patients. Three Phase III studies compared semuloparin and enoxaparin after major orthopedic surgery: elective knee replacement (SAVE-KNEE), elective hip replacement (SAVE-HIP1) and hip fracture surgery (SAVE-HIP2). All studies were multinational, randomized and double-blind. Semuloparin and enoxaparin were administered for 7-10 days after surgery. Mandatory bilateral venography was to be performed between days 7 and 11. The primary efficacy endpoint was a composite of any deep vein thrombosis, non-fatal pulmonary embolism or all-cause death. Safety outcomes included major bleeding, clinically relevant non-major (CRNM) bleeding, and any clinically relevant bleeding (major bleeding plus CRNM). In total, 1150, 2326 and 1003 patients were randomized in SAVE-KNEE, SAVE-HIP1 and SAVE-HIP2, respectively. In all studies, the incidences of the primary efficacy endpoint were numerically lower in the semuloparin group vs. the enoxaparin group, but the difference was statistically significant only in SAVE-HIP1. In SAVE-HIP1, clinically relevant bleeding and major bleeding were significantly lower in the semuloparin vs. the enoxaparin group. In SAVE-KNEE and SAVE-HIP2, clinically relevant bleeding tended to be higher in the semuloparin group, but rates of major bleeding were similar in the two groups. Other safety parameters were generally similar between treatment groups. Semuloparin was superior to enoxaparin for VTE prevention after hip replacement surgery, but failed to demonstrate superiority after knee replacement surgery and hip fracture surgery. Semuloparin and enoxaparin exhibited generally similar safety profiles. © 2012 International Society on Thrombosis and Haemostasis.

Forensic investigation of two voided slab bridges in the Virginia Department of Transportation's Richmond District.

DOT National Transportation Integrated Search

2017-06-01

The precast prestressed concrete voided slab structure is a popular bridge design because of its rapid construction and cost : savings in terms of eliminating formwork at the jobsite. However, the longitudinal shear transfer mechanism often fails, le...

An Asian perspective on organ transplantation.

PubMed

Tai, Michael Cheng-tek

2009-01-01

The organ transplantation seems to have become a route practice of modern medical treatment when a patient's organ fails providing that she/he can afford the cost and a suitable organ is found. This practice, however, was not without scepticism and reservation at least to some Asians, for instance, Japan has been reluctant to launch a brave search for organs to save any patient whose organs fail. The western world including Vatican has seen donating one's organ for transplantation to save others as an act of love. Compassion is one of the main teachings in Asian tradition too, therefore culturally, Asians should be in favour of this modern medical treatment. But the ancient teachings of Asia also call for respecting parents by carefully safeguarding the gift of body that they gave and abiding in Tao to follow the flow of nature. What will the Asian ancient sages say to this new modern medical technology? This article will examine the teachings of Confucianism, Taoism and Buddhism to find out how they respond to the procedures of organ transplantation.

INCREASING SAVING BEHAVIOR THROUGH AGE-PROGRESSED RENDERINGS OF THE FUTURE SELF.

PubMed

Hershfield, Hal E; Goldstein, Daniel G; Sharpe, William F; Fox, Jesse; Yeykelis, Leo; Carstensen, Laura L; Bailenson, Jeremy N

2011-11-01

Many people fail to save what they need to for retirement (Munnell, Webb, and Golub-Sass 2009). Research on excessive discounting of the future suggests that removing the lure of immediate rewards by pre-committing to decisions, or elaborating the value of future rewards can both make decisions more future-oriented. In this article, we explore a third and complementary route, one that deals not with present and future rewards, but with present and future selves. In line with thinkers who have suggested that people may fail, through a lack of belief or imagination, to identify with their future selves (Parfit 1971; Schelling 1984), we propose that allowing people to interact with age-progressed renderings of themselves will cause them to allocate more resources toward the future. In four studies, participants interacted with realistic computer renderings of their future selves using immersive virtual reality hardware and interactive decision aids. In all cases, those who interacted with virtual future selves exhibited an increased tendency to accept later monetary rewards over immediate ones.

CD4+ T-cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

PubMed Central

Rakhra, Kavya; Bachireddy, Pavan; Zabuawala, Tahera; Zeiser, Robert; Xu, Liwen; Kopelman, Andrew; Fan, Alice C.; Yang, Qiwei; Braunstein, Lior; Crosby, Erika; Ryeom, Sandra; Felsher, Dean W.

2010-01-01

Summary Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the induction and restraint of tumorigenesis, but their role in oncogene inactivation mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4+ T-cells, is required for the induction of cellular senescence, shut down of angiogenesis and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T-cell acute lymphoblastic lymphoma and pro-B-cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4+ T-cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction. PMID:21035406

FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation.

PubMed

Monsonego-Ornan, E; Adar, R; Rom, E; Yayon, A

2002-09-25

A crucial aspect of ligand-mediated receptor activation and shut-down is receptor internalization and degradation. Here we compared the ubiquitylation of either wild type or a K508A 'kinase-dead' mutant of fibroblast growth factor receptor 3 (FGFR3) with that of its naturally occurring overactive mutants, G380R as in achondroplasia, or K650E involved in thanatophoric dysplasia. Fibroblast growth factor receptors ubiquitylation was found to be directly proportional to their intrinsic tyrosine kinase activity, both of which could be blocked using kinase inhibitors. Despite excessive ubiquitylation, both overactive mutants failed to be efficiently degraded, even when challenged with ligand or overexpression of c-Cbl, a putative E3 ligase. We conclude that phosphorylation is essential for FGFR3 ubiquitylation, but is not sufficient to induce downregulation of its internalization resistant mutants.

No-Fail Software Gifts for Kids.

ERIC Educational Resources Information Center

Buckleitner, Warren

1996-01-01

Reviews children's software packages: (1) "Fun 'N Games"--nonviolent games and activities; (2) "Putt-Putt Saves the Zoo"--matching, logic games, and animal facts; (3) "Big Job"--12 logic games with video from job sites; (4) "JumpStart First Grade"--15 activities introducing typical school lessons; and (5) "Read, Write, & Type!"--progressively…

It's in Our Hands Now

ERIC Educational Resources Information Center

Ward, Jane

2010-01-01

The world's political leaders failed to agree a fair, ambitious and legally binding accord that would protect the planet from catastrophic global warming at the United Nations' Copenhagen conference on climate change. This makes grassroots action all the more essential to save the world from devastating climate change. The UK Government championed…

Passive shut-down heat removal system

DOEpatents

Hundal, Rolv; Sharbaugh, John E.

1988-01-01

An improved shut-down heat removal system for a liquid metal nuclear reactor of the type having a vessel for holding hot and cold pools of liquid sodium is disclosed herein. Generally, the improved system comprises a redan or barrier within the reactor vessel which allows an auxiliary heat exchanger to become immersed in liquid sodium from the hot pool whenever the reactor pump fails to generate a metal-circulating pressure differential between the hot and cold pools of sodium. This redan also defines an alternative circulation path between the hot and cold pools of sodium in order to equilibrate the distribution of the decay heat from the reactor core. The invention may take the form of a redan or barrier that circumscribes the inner wall of the reactor vessel, thereby defining an annular space therebetween. In this embodiment, the bottom of the annular space communicates with the cold pool of sodium, and the auxiliary heat exchanger is placed in this annular space just above the drawn-down level that the liquid sodium assumes during normal operating conditions. Alternatively, the redan of the invention may include a pair of vertically oriented, concentrically disposed standpipes having a piston member disposed between them that operates somewhat like a pressure-sensitive valve. In both embodiments, the cessation of the pressure differential that is normally created by the reactor pump causes the auxiliary heat exchanger to be immersed in liquid sodium from the hot pool. Additionally, the redan in both embodiments forms a circulation flow path between the hot and cold pools so that the decay heat from the nuclear core is uniformly distributed within the vessel.

Physics and function of operating room suction.

PubMed

Meagher, A P; Hugh, T B; Li, B; Montano, S R

1991-09-01

A study was done to evaluate the performance of suction apparatus in the operating room. The investigation was prompted by perceived poor suction performance in a suite of new operating rooms built in accordance with Standards Australia (SA) specifications. SA performance tests were conducted on each of four suction outlets in nine operating rooms. All 36 outlets complied with SA standards for flow-rate (minimum 40 L/min) and occluded negative pressure (ONP; minimum -60 kPa). However, 24 collection units failed to comply with standards (ONP) of -40 kPa achieved in less than 4 s when a 4 L disposable suction apparatus was connected (mean time to ONP: 6.1 s, 95% confidence interval: 4.9, 7.3). When smaller capacity suction jars were substituted, more units met SA standards. The standards therefore need revision to include specification of the capacity of the collecting apparatus. Other factors that were found to degrade suction performance significantly were air leakage and defective shut-off valves. The physical principles involved in operating room suction are described. Surgeons and anaesthetists should understand these principles, and it is recommended that a simple pre-operative check of the suction apparatus should be carried out, as follows: (1) Turn the wall control knob fully on, and disconnect the suction apparatus. The gauge should register zero. (2) Connect the suction jars. If the indicated gauge pressure is in excess of -15 kPa, investigate the equipment for excessive resistance, particularly in the shut-off valve, which should be replaced with a new unit if necessary.(ABSTRACT TRUNCATED AT 250 WORDS)

Teaching Conservation in Elementary Schools. Bulletin, 1938, No. 14

ERIC Educational Resources Information Center

Bathurst, Effie, G.

1940-01-01

That which legislation many times fails to accomplish with adults, organized public education achieves through children. There is no better way, and perhaps no other way, to save the Nation's natural resources from three centuries of ruthless exploitation than by a program of adequate instruction in the Nation's schools. Children cannot begin too…

Guess Again: Will Changing the Grades Save Middle-Level Education?

ERIC Educational Resources Information Center

Beane, James; Lipka, Richard

2006-01-01

Blaming unsatisfactory student achievement on the middle school concept is a case of mistaken identity. Too many middle schools have failed to fully implement the middle school concept. Based on statements from the Carnegie Council and the National Middle School Association, the middle school concept calls for improved academic achievement for all…

Response to the Task Force on School Governance.

ERIC Educational Resources Information Center

Denoyer, Richard A.

Although the Task Force on School Governance report claims that restructuring of school boards is essential to save the nation's failing schools, the real failure is society itself. Societal problems such as the nation's $4 trillion debt, air and water pollution, crime, drug abuse, and special interest lobbies abound, and legislators'…

INCREASING SAVING BEHAVIOR THROUGH AGE-PROGRESSED RENDERINGS OF THE FUTURE SELF

PubMed Central

HERSHFIELD, HAL E.; GOLDSTEIN, DANIEL G.; SHARPE, WILLIAM F.; FOX, JESSE; YEYKELIS, LEO; CARSTENSEN, LAURA L.; BAILENSON, JEREMY N.

2014-01-01

Many people fail to save what they need to for retirement (Munnell, Webb, and Golub-Sass 2009). Research on excessive discounting of the future suggests that removing the lure of immediate rewards by pre-committing to decisions, or elaborating the value of future rewards can both make decisions more future-oriented. In this article, we explore a third and complementary route, one that deals not with present and future rewards, but with present and future selves. In line with thinkers who have suggested that people may fail, through a lack of belief or imagination, to identify with their future selves (Parfit 1971; Schelling 1984), we propose that allowing people to interact with age-progressed renderings of themselves will cause them to allocate more resources toward the future. In four studies, participants interacted with realistic computer renderings of their future selves using immersive virtual reality hardware and interactive decision aids. In all cases, those who interacted with virtual future selves exhibited an increased tendency to accept later monetary rewards over immediate ones. PMID:24634544

Architectural Analysis of Complex Evolving Systems of Systems

NASA Technical Reports Server (NTRS)

Lindvall, Mikael; Stratton, William C.; Sibol, Deane E.; Ray, Arnab; Ackemann, Chris; Yonkwa, Lyly; Ganesan, Dharma

2009-01-01

The goal of this collaborative project between FC-MD, APL, and GSFC and supported by NASA IV&V Software Assurance Research Program (SARP), was to develop a tool, Dynamic SAVE, or Dyn-SAVE for short, for analyzing architectures of systems of systems. The project team was comprised of the principal investigator (PI) from FC-MD and four other FC-MD scientists (part time) and several FC-MD students (full time), as well as, two APL software architects (part time), and one NASA POC (part time). The PI and FC-MD scientists together with APL architects were responsible for requirements analysis, and for applying and evaluating the Dyn-SAVE tool and method. The PI and a group of FC-MD scientists were responsible for improving the method and conducting outreach activities, while another group of FC-MD scientists were responsible for development and improvement of the tool. Oversight and reporting was conducted by the PI and NASA POC. The project team produced many results including several prototypes of the Dyn-SAVE tool and method, several case studies documenting how the tool and method was applied to APL s software systems, and several published papers in highly respected conferences and journals. Dyn-SAVE as developed and enhanced throughout this research period, is a software tool intended for software developers and architects, software integration testers, and persons who need to analyze software systems from the point of view of how it communicates with other systems. Using the tool, the user specifies the planned communication behavior of the system modeled as a sequence diagram. The user then captures and imports the actual communication behavior of the system, which is then converted and visualized as a sequence diagram by Dyn-SAVE. After mapping the planned to the actual and specifying parameter and timing constraints, Dyn-SAVE detects and highlights deviations between the planned and the actual behavior. Requirements based on the need to analyze two inter-system communication protocols that are representative of protocols used in the Aerospace industry have been specified. The protocols are related: APL s Common Ground System (CGS) as used in the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) and the Radiation Belt Space Probes (RBSP) missions. The analyzed communications were implementations of the Telemetry protocol and the CCSDS File Delivery Protocol (CFDP) protocol. Based on these requirements, three prototypes of Dyn-SAVE were developed and applied to these protocols. The application of Dyn-SAVE to these protocols resulted in the detection of several issues. Dyn-SAVE was also applied to several Testbeds that have previously been used for experimentation earlier on this project, as well as, to other protocols and logs for testing its broader applicability. For example, Dyn-SAVE was used to analyze 1) the communication pattern between a web browser and a web server, 2) the system log of a computer in order to detect offnominal computer shut-down behavior, and 3) the actual test cases of NASA Goddard s Core Flight System (CFS) and automatically generated test cases in order to determine the overlap between the two sets of test cases. In all cases, Dyn-SAVE assisted in providing insightful conclusions about each of the cases identified above.

43 CFR 3163.1 - Remedies for acts of noncompliance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ONSHORE OIL AND GAS OPERATIONS... environment, production accountability, or royalty income, the authorized officer may shut down operations... health and safety, the environment, production accountability, or royalty income. Shut-in actions for...

43 CFR 3163.1 - Remedies for acts of noncompliance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ONSHORE OIL AND GAS OPERATIONS... environment, production accountability, or royalty income, the authorized officer may shut down operations... health and safety, the environment, production accountability, or royalty income. Shut-in actions for...

43 CFR 3163.1 - Remedies for acts of noncompliance.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ONSHORE OIL AND GAS OPERATIONS... environment, production accountability, or royalty income, the authorized officer may shut down operations... health and safety, the environment, production accountability, or royalty income. Shut-in actions for...

43 CFR 3163.1 - Remedies for acts of noncompliance.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) ONSHORE OIL AND GAS OPERATIONS... environment, production accountability, or royalty income, the authorized officer may shut down operations... health and safety, the environment, production accountability, or royalty income. Shut-in actions for...

Qualitative Phenomenological Examination of IT Project Management in Pharmaceutical Industry

ERIC Educational Resources Information Center

Ly, Phil

2013-01-01

The purpose of this study was to examine what caused IT projects to fail at a high rate in the pharmaceutical industry. IT projects failures delayed development of new drugs that can help save lives. It was imperative to evaluate what caused project failures because the collateral damage was delay in drug development. This qualitative…

How Manipulatives Affect the Mathematics Achievement of Students in Nigerian Schools

ERIC Educational Resources Information Center

Aburime, F. Ehi.

2007-01-01

Mathematics is a very important subject in Nigeria. Yet, for more than twenty years, mathematics education in Nigeria has been in a sorry state. Mathematics achievement has been very low and frustrating. So far, every effort made to save Nigerian education from the devastating effect of persistent poor mathematics achievement has failed. An…

Only STEM Can Save Us? Examining Race, Place, and STEM Education as Property

ERIC Educational Resources Information Center

Bullock, Erika C.

2017-01-01

The rhetoric about science, technology, engineering, and mathematics (STEM) education in urban schools reflects a desire to imagine a new city that is poised to compete in a STEM-centered future. Therefore, STEM has been positioned as a critical part of urban education reform efforts. In various US cities, schools labeled as "failing"…

Popliteal Artery Repair in Massively Transfused Military Trauma Casualties: A Pursuit to Save Life and Limb

DTIC Science & Technology

2010-07-01

were centrally scored and calculated by trained re- search nurses and staff using ISS-98 after patient discharge. A Level I facility was defined as a...casualties, once evacuated to the United States, had limited remaining autogenous vein and required prosthetic grafts in the secondary management of failed

Schools and Classes for the Blind 1926-27. Bulletin, 1928, No. 9

ERIC Educational Resources Information Center

Phillips, Frank M.

1928-01-01

This report contains statistics concerning schools and classes for blind pupils for the year 1926-27. Reports are included for 80 schools and institutions. Data concerning sight-saving classes are not included where it is possible to separate them from data concerning classes for the blind. For schools that failed to report, statistics for a…

The impact of the 'Better Care Better Value' prescribing policy on the utilisation of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for treating hypertension in the UK primary care setting: longitudinal quasi-experimental design.

PubMed

Baker, Amanj; Chen, Li-Chia; Elliott, Rachel A; Godman, Brian

2015-09-10

In April/2009, the UK National Health Service initiated four Better Care Better Value (BCBV) prescribing indicators, one of which encouraged the prescribing of cheaper angiotensin-converting enzyme inhibitors (ACEIs) instead of expensive angiotensin receptor blockers (ARBs), with 80 % ACEIs/20 % ARBs as a proposed, and achievable target. The policy was intended to save costs without affecting patient outcomes. However, little is known about the actual impact of the BCBV indicator on ACEIs/ARBs utilisation and cost-savings. Therefore, this study aimed to evaluate the impact of BCBV policy on ACEIs/ARBs utilisation and cost-savings, including exploration of regional variations of the policy's impact. This cross-sectional study used data from the UK Clinical Practice Research Datalink. Segmented time-series analysis was applied to monthly ACEIs prescription proportion, adjusted number of ACEIs/ARBs prescriptions and costs. Overall, the proportion of ACEIs prescription decreased during the study period from 71.2% in April/2006 to 70.7% in March/2012, with a small but a statistically significant pre-policy reduction in its monthly trend of 0.02% (p < 0.001). Instantly after its initiation, the policy was associated with a sudden reduction in the proportion of ACEIs prescription; however, it resulted in a statistically significant increase in the post-policy monthly trend of ACEIs prescription proportion of 0.013% (p < 0.001), resulting in an overall post-policy slope of -0.007%. Despite this post-policy induced increment, the policy failed to achieve the 80% target, which resulted in missing a potential cost-saving opportunity. The pre-policy trend of the adjusted number of ACEIs/ARBs prescriptions was increasing; however, their trends declined after the policy implementation. The policy affected neither total ACEIs/ARBs cost nor individual ACEIs or ARBs costs. ACEIs/ARBs utilisation was not affected by the BCBV policy. The small increase in post-policy ACEIs prescription proportion was not associated with any savings. This study represents a case study of a failed or ineffective policy and thus provides key learning lessons for other healthcare authorities. Given the existing opportunity of potential cost-savings from achieving the 80 % target, specific measures would be needed to enhance the policy implementation and uptake; however, this must be balanced against other cost-saving policies in other high-priority areas.

The future of nuclear power: A world-wide perspective

NASA Astrophysics Data System (ADS)

Aktar, Ismail

This study analyzes the future of commercial nuclear electric generation worldwide using the Environmental Kuznets Curve (EKC) concept. The Tobit panel data estimation technique is applied to analyze the data between 1980 and 1998 for 105 countries. EKC assumes that low-income countries increase their nuclear reliance in total electric production whereas high-income countries decrease their nuclear reliance. Hence, we expect that high-income countries should shut down existing nuclear reactors and/or not build any new ones. We encounter two reasons for shutdowns: economic or political/environmental concerns. To distinguish these two effects, reasons for shut down are also investigated by using the Hazard Model technique. Hence, the load factor of a reactor is used as an approximation for economic reason to shut down the reactor. If a shut downed reactor had high load factor, this could be attributable to political/environmental concern or else economic concern. The only countries with nuclear power are considered in this model. The two data sets are created. In the first data set, the single entry for each reactor is created as of 1998 whereas in the second data set, the multiple entries are created for each reactor beginning from 1980 to 1998. The dependent variable takes 1 if operational or zero if shut downed. The empirical findings provide strong evidence for EKC relationship for commercial nuclear electric generation. Furthermore, higher natural resources suggest alternative electric generation methods rather than nuclear power. Economic index as an institutional variable suggests higher the economic freedom, lower the nuclear electric generation as expected. This model does not support the idea to cut the carbon dioxide emission via increasing nuclear share. The Hazard Model findings suggest that higher the load factor is, less likely the reactor will shut down. However, if it is still permanently closed downed, then this could be attributable to political hostility against nuclear power. There are also some projections indicating which reactors are most/least likely to be shut downed from the logit model. We also project which countries are most likely to increase/decrease their nuclear reliance from the residuals of EKC model.

MOSES Support Platform

DTIC Science & Technology

2008-02-01

drain with collector • Final pressure switch with gauge and automatic shut- off • (2) Hour meter • Oil filled finel pressure gauge 0~400bar/5800psi...Automatic condensate drain system Final pressure switch with gauge and automatic shut-off (2) Hour meter, (2) On/Off Switch Filling Connection Four

49 CFR 229.113 - Warning notice.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Warning notice. 229.113 Section 229.113....113 Warning notice. Whenever any steam generator has been shut down because of defects, a distinctive warning notice giving reasons for the shut-down shall be conspicuously attached near the steam generator...

49 CFR 229.113 - Warning notice.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Warning notice. 229.113 Section 229.113....113 Warning notice. Whenever any steam generator has been shut down because of defects, a distinctive warning notice giving reasons for the shut-down shall be conspicuously attached near the steam generator...

49 CFR 229.113 - Warning notice.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Warning notice. 229.113 Section 229.113....113 Warning notice. Whenever any steam generator has been shut down because of defects, a distinctive warning notice giving reasons for the shut-down shall be conspicuously attached near the steam generator...

49 CFR 229.113 - Warning notice.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Warning notice. 229.113 Section 229.113....113 Warning notice. Whenever any steam generator has been shut down because of defects, a distinctive warning notice giving reasons for the shut-down shall be conspicuously attached near the steam generator...

49 CFR 229.113 - Warning notice.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Warning notice. 229.113 Section 229.113....113 Warning notice. Whenever any steam generator has been shut down because of defects, a distinctive warning notice giving reasons for the shut-down shall be conspicuously attached near the steam generator...

When water saving limits recycling: Modelling economy-wide linkages of wastewater use.

PubMed

Luckmann, Jonas; Grethe, Harald; McDonald, Scott

2016-01-01

The reclamation of wastewater is an increasingly important water source in parts of the world. It is claimed that wastewater recycling is a cheap and reliable form of water supply, which preserves water resources and is economically efficient. However, the quantity of reclaimed wastewater depends on water consumption by economic agents connected to a sewage system. This study uses a Computable General Equilibrium (CGE) model to analyse such a cascading water system. A case study of Israel shows that failing to include this linkage can lead to an overestimation of the potential of wastewater recycling, especially when economic agents engage in water saving. Copyright © 2015 Elsevier Ltd. All rights reserved.

Cost analysis of the Mercedes-Benz occupant detection system for air bag shut-off

DOT National Transportation Integrated Search

1997-04-01

The objective of this project is to develop the variable manufacturing costs and lead time estimates of an "occupant detection system for air bag shut off". The Mercedes-Benz system was used as a base for developing this data. The system consists of ...

Poor Women in Psychological Research: Shut Up and Shut Out.

ERIC Educational Resources Information Center

Reid, Pamela Trotman

1993-01-01

Raises the issue of recognizing the diversity of poor women in psychological research, focusing on the need to disentangle ethnicity and class and the limitations of adopting a middle-class white perspective. Possible causes of exclusion in addition to racism and suggestions for achieving feminist goals are considered. (SLD)

76 FR 69163 - Airworthiness Directives; Fokker Services B.V. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-08

... fuel fire shut-off valve indication logic had been introduced during production on a limited number of..., of the crossfeed indication logic and power supply and of the fuel fire shut-off valve indication logic. * * * * * Required actions also include modifying the overhead panel (introduce provisions for a...

75 FR 65484 - Update to Notice of Financial Institutions for Which the Federal Deposit Insurance Corporation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

... visit the Corporation Web site at http://www.fdic.gov/bank/individual/failed/banklist.html or contact... Liquidation [In alphabetical order] FDIC Ref. No. Bank name City State Date closed 10297 Premier Bank......... Jefferson City....... MO 10/15/2010 10298 Security Savings Olathe KS 10/15/2010 Bank, F.S.B. 10299 West...

Hey! Bankers! Leave Those Kids Alone: The Fight to Save Islington Green School

ERIC Educational Resources Information Center

Muller, Ken

2008-01-01

The author traces the history of the campaign to stop Islington Green School being closed and turned into an academy specialising in business and financial services. Although the campaign, after a number of successes now looks as if it might fail in its immediate objective, the author argues that the battle was still worth fighting because of the…

78 FR 23696 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

... longitudinal main rotor actuator piston after shut-down of the external pump drive, during rigging of the main... rotor controls, of movement of the longitudinal main rotor actuator piston after shut-down of the external pump drive. Such movement could cause incorrect rigging results. The proposed actions are intended...

30 CFR 250.527 - What must I include in my casing pressure request?

Code of Federal Regulations, 2011 CFR

2011-07-01

... casing/riser calculated MAWOPs; (h) All casing/riser pre-bleed down pressures; (i) Shut-in tubing... test (oil, gas, basic sediment, and water); (l) Well status (shut-in, temporarily abandoned, producing, injecting, or gas lift); (m) Well type (dry tree, hybrid, or subsea); (n) Date of diagnostic test; (o) Well...

40 CFR 62.14471 - When must I comply with this subpart if I plan to shut down?

Code of Federal Regulations, 2010 CFR

2010-07-01

... FACILITIES AND POLLUTANTS Federal Plan Requirements for Hospital/Medical/Infectious Waste Incinerators... documentation must include an evaluation of the option to transport your waste offsite to a commercial medical... an onsite alternative waste treatment technology before you shut down your HMIWI, Date when you will...

Preventing the Shut-Down: Embodied Critical Care in a Teacher Educator's Practice

ERIC Educational Resources Information Center

Trout, Muffet; Basford, Letitia

2016-01-01

This article explores the practice of one teacher educator to understand how she mitigates student resistance to prevent what we call "the shut-down" when teaching mostly White students about systemic forms of oppression. Engaging students in conversations about oppression does not in itself disrupt systems of power and privilege in…

Emission characteristics and vapour/particulate phase distributions of PCDD/F in a hazardous waste incinerator under transient conditions

PubMed Central

Wang, Chao; Cen, Kefa; Ni, Mingjiang; Li, Xiaodong

2018-01-01

Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/F) emission characteristics and vapour/particulate phase partitions under three continued operation conditions, i.e. shut-down, start-up and after start-up, were investigated by sampling stack gas. The results indicated that the PCDD/F emission levels were 0.40–18.03 ng I-TEQ Nm−3, much higher than the annual monitoring level (0.016 ng I-TEQ Nm−3). Additionally, the PCDD/F emission levels in start-up were higher than the other two conditions. Furthermore, the PCDD/F congener profiles differed markedly between shut-down and start-up, and the chlorination degree of PCDD/F increased in shut-down and decreased evidently in start-up. Moreover, PCDD/F vapour/particulate phase distributions varied significantly under three transient conditions. The PCDD/F vapour phase proportion decreased as the shut-down process continued, then increased as the start-up process proceeded, finally more than 98% of the PCDD/F congeners were distributed in the vapour phase after start-up. The correlations between log(Cv/Cs) versus log pL0 of each PCDD/F congener in stack gas were disorganized in shut-down, and trend to a linear distribution after start-up. Besides, polychlorinated biphenyl emissions show behaviour similar to that of PCDD/F, and the lower chlorinated congeners have a stronger relationship with 2,3,7,8-PCDD/Fs, such as M1CB and D2CB. PMID:29410821

Computer simulation of reservoir depletion and oil flow from the Macondo well following the Deepwater Horizon blowout

USGS Publications Warehouse

Hsieh, Paul

2010-01-01

This report describes the application of a computer model to simulate reservoir depletion and oil flow from the Macondo well following the Deepwater Horizon blowout. Reservoir and fluid data used for model development are based on (1) information released in BP's investigation report of the incident, (2) information provided by BP personnel during meetings in Houston, Texas, and (3) calibration by history matching to shut-in pressures measured in the capping stack during the Well Integrity Test. The model is able to closely match the measured shut-in pressures. In the simulation of the 86-day period from the blowout to shut in, the simulated reservoir pressure at the well face declines from the initial reservoir pressure of 11,850 pounds per square inch (psi) to 9,400 psi. After shut in, the simulated reservoir pressure recovers to a final value of 10,300 psi. The pressure does not recover back to the initial pressure owing to reservoir depletion caused by 86 days of oil discharge. The simulated oil flow rate declines from 63,600 stock tank barrels per day just after the Deepwater Horizon blowout to 52,600 stock tank barrels per day just prior to shut in. The simulated total volume of oil discharged is 4.92 million stock tank barrels. The overall uncertainty in the simulated flow rates and total volume of oil discharged is estimated to be + or - 10 percent.

Digital flight control systems

NASA Technical Reports Server (NTRS)

Caglayan, A. K.; Vanlandingham, H. F.

1977-01-01

The design of stable feedback control laws for sampled-data systems with variable rate sampling was investigated. These types of sampled-data systems arise naturally in digital flight control systems which use digital actuators where it is desirable to decrease the number of control computer output commands in order to save wear and tear of the associated equipment. The design of aircraft control systems which are optimally tolerant of sensor and actuator failures was also studied. Detection of the failed sensor or actuator must be resolved and if the estimate of the state is used in the control law, then it is also desirable to have an estimator which will give the optimal state estimate even under the failed conditions.

SU-E-T-660: Quantitative Fault Testing for Commissioning of Proton Therapy Machines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reilly, M; Rankine, L; Grantham, K

2015-06-15

Purpose: To ensure proper fault testing for the first single room proton therapy machine by establishing a common set of acceptance testing and commissioning parameters with the manufacturer. The following work details the parameters tested and associated results. Methods: Dose rates in service mode were varied to ensure that when the threshold for maximum or minimum MU/min was met, the beam promptly shut off. The flatness parameter was tested by purposely assigning an incorrect secondary scatter, to ensure the beam shut off when detecting a heterogeneous profile. The beam symmetry parameter was tested by altering the steering coil up tomore » 3.0A, thereby forcing the beam to be asymmetric and shut off. Lastly, the quench system was tested by ramping down the magnet to 5% capacity, whereby the quench button was engaged to bring down the magnet current to a safe level. Results: A dose rate increase or decrease in excess of 10% shut the beam off within 5 seconds as observed by the current on a Matrixx ionization chamber array (IBA Dosimetry, Bartlett, TN) A 3.0A change in the beam steering coil introduced a 2% change in the flatness and symmetry profiles with respect to baseline measurements resulting in the beam shutting off within 5 seconds. An incorrect 2nd scatterer introduced a flatness of 4.1% and symmetry of 6.4% which immediately triggered a beam shut off. Finally, the quench system worked as expected during the ramp down procedure. Conclusion: A fault testing plan to check dosimetric faults and the quench system was performed for the first single room proton therapy system. All dosimetric parameters and machine conditions were met to our satisfaction. We propose that the same type of fault testing should be applied to any proton system during commissioning, including scanning beam systems.« less

Forgotten but not gone: savings for pictures and words in long-term memory.

PubMed

MacLeod, C M

1988-04-01

Five experiments examined the relearning of words, simple line-drawing pictures, and complex photographic pictures after retention intervals of 1 to 10 weeks. For those items that were neither recalled nor recognized, the identical item was relearned better than an unrelated control item, as measured by a recall test following relearning. This relearning advantage in recall held for all three classes of material and extended to the cross-modality case (i.e., picture-word and word-picture) and the same-referent case (i.e., two pictures of the same object). However, recognition tests of relearning failed to detect this same relearning advantage for apparently forgotten items. Taken together, these findings conflict with the existing account of savings. Most fundamental, the classic argument that relearning serves a trace-strengthening function is undetermined by the observed recall-recognition contrast. An alternative explanation of savings is suggested wherein relearning assists retrieval of information, thereby affecting recall in particular.

A Case Report: Cornerstone Health Care Reduced the Total Cost of Care Through Population Segmentation and Care Model Redesign.

PubMed

Green, Dale E; Hamory, Bruce H; Terrell, Grace E; O'Connell, Jasmine

2017-08-01

Over the course of a single year, Cornerstone Health Care, a multispecialty group practice in North Carolina, redesigned the underlying care models for 5 of its highest-risk populations-late-stage congestive heart failure, oncology, Medicare-Medicaid dual eligibles, those with 5 or more chronic conditions, and the most complex patients with multiple late-stage chronic conditions. At the 1-year mark, the results of the program were analyzed. Overall costs for the patients studied were reduced by 12.7% compared to the year before enrollment. All fully implemented programs delivered between 10% and 16% cost savings. The key area for savings factor was hospitalization, which was reduced by 30% across all programs. The greatest area of cost increase was "other," a category that consisted in large part of hospice services. Full implementation was key; 2 primary care sites that reverted to more traditional models failed to show the same pattern of savings.

75 FR 39798 - Airworthiness Directives; Bombardier, Inc. Model DHC-8-400, -401, and -402 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

.... 1 hydraulic system. In one case, the hydraulic system control logic did not shut down the PTU and... unit (PTU) control logic, including the provision of automatic PTU shutdown in the event of loss of... one case, the hydraulic system control logic did not shut down the PTU and the overspeed condition...

Potential Energy Cost Savings from Increased Commercial Energy Code Compliance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenberg, Michael I.; Hart, Philip R.; Athalye, Rahul A.

2016-08-22

An important question for commercial energy code compliance is: “How much energy cost savings can better compliance achieve?” This question is in sharp contrast to prior efforts that used a checklist of code requirements, each of which was graded pass or fail. Percent compliance for any given building was simply the percent of individual requirements that passed. A field investigation method is being developed that goes beyond the binary approach to determine how much energy cost savings is not realized. Prototype building simulations were used to estimate the energy cost impact of varying levels of non-compliance for newly constructed officemore » buildings in climate zone 4C. Field data collected from actual buildings on specific conditions relative to code requirements was then applied to the simulation results to find the potential lost energy savings for a single building or for a sample of buildings. This new methodology was tested on nine office buildings in climate zone 4C. The amount of additional energy cost savings they could have achieved had they complied fully with the 2012 International Energy Conservation Code is determined. This paper will present the results of the test, lessons learned, describe follow-on research that is needed to verify that the methodology is both accurate and practical, and discuss the benefits that might accrue if the method were widely adopted.« less

Evaluation of selected chemical processes for production of low-cost silicon, phase 2

NASA Technical Reports Server (NTRS)

Blocher, J. M., Jr.; Browning, M. F.; Wilson, W. J.; Carmichael, D. C.

1977-01-01

Potential designs for an integrated fluidized-bed reactor/zinc vaporizer/SiCl4 preheater unit are being considered and heat-transfer calculations have been initiated on versions of the zinc vaporizer section. Estimates of the cost of the silicon prepared in the experimental facility have been made for projected capacities of 25, 50, 75, and 100 metric ton of silicon. A 35 percent saving is obtained in going from 25 metric ton/year to the 50 metric ton/year level. This analysis, coupled with the recognition that use of two reactors in the 50 metric ton/year version allows for continued operation (at reduced capacity) with one reactor shut down, has resulted in a recommendation for adoption of an experimental facility capacity of 50 metric ton/year or greater. At this stage, the change to a larger size facility would not increase the design costs appreciably. In the experimental support program, the effects of seed bed particle size and depth were studied, and operation of the miniplant with a new zinc vaporizer was initiated, revealing the need for modification of the latter.

Power Aware Management Middleware for Multiple Radio Interfaces

NASA Astrophysics Data System (ADS)

Friedman, Roy; Kogan, Alex

Modern mobile phones and laptops are equipped with multiple wireless communication interfaces, such as WiFi and Bluetooth (BT), enabling the creation of ad-hoc networks. These interfaces significantly differ from one another in their power requirements, transmission range, bandwidth, etc. For example, BT is an order of magnitude more power efficient than WiFi, but its transmission range is an order of magnitude shorter. This paper introduces a management middleware that establishes a power efficient overlay for such ad-hoc networks, in which most devices can shut down their long range power hungry wireless interface (e.g., WiFi). Yet, the resulting overlay is fully connected, and for capacity and latency needs, no message ever travels more than 2k short range (e.g., BT) hops, where k is an arbitrary parameter. The paper describes the architecture of the solution and the management protocol, as well as a detailed simulations based performance study. The simulations largely validate the ability of the management infrastructure to obtain considerable power savings while keeping the network connected and maintaining reasonable latency. The performance study covers both static and mobile networks.

Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation.

PubMed

Weiser, Douglas C; Pyati, Ujwal J; Kimelman, David

2007-06-15

Convergent extension of the mesoderm is the major driving force of vertebrate gastrulation. During this process, mesodermal cells move toward the future dorsal side of the embryo, then radically change behavior as they initiate extension of the body axis. How cells make this transition in behavior is unknown. We have identified the scaffolding protein and tumor suppressor Gravin as a key regulator of this process in zebrafish embryos. We show that Gravin is required for the conversion of mesodermal cells from a highly migratory behavior to the medio-laterally intercalative behavior required for body axis extension. In the absence of Gravin, paraxial mesodermal cells fail to shut down the protrusive activity mediated by the Rho/ROCK/Myosin II pathway, resulting in embryos with severe extension defects. We propose that Gravin functions as an essential scaffold for regulatory proteins that suppress the migratory behavior of the mesoderm during gastrulation, and suggest that this function also explains how Gravin inhibits invasive behaviors in metastatic cells.

Differences in Reservoir Bathymetry, Area, and Capacity Between December 20-22, 2005, and June 16-19, 2008, for Lower Taum Sauk Reservoir, Reynolds County, Missouri

USGS Publications Warehouse

Wilson, Gary L.; Richards, Joseph M.

2008-01-01

On December 14, 2005, the embankment of the upper reservoir at the Taum Sauk pump storage facility, Reynolds County, Missouri, catastrophically failed and flooded the East Fork Black River, depositing debris and sediment in Johnson's Shut-Ins State Park, the lower Taum Sauk Reservoir, and downstream in the Black River (location map). A bathymetric survey conducted December 20-22, 2005, documented the bathymetry of the lower Taum Sauk Reservoir after the upper reservoir failure (Rydlund, 2006). After subsequent excavation of sediment and debris from the lower reservoir by Ameren Union Electric (UE), the U.S. Geological Survey (USGS), in collaboration with Roux Associates Inc., conducted a bathymetric survey of the lower Taum Sauk Reservoir on June 16-19, 2008, to prepare a current (2008) bathymetric map (fig. 1) for the lower reservoir, establish a current (2008) elevation-area and capacity table, and determine reservoir area and capacity differences between the 2005 and 2008 bathymetric surveys.

46 CFR 154.1010 - Electrical equipment in gas-dangerous space or zone.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... (c) A submerged cargo pump motor may be in a cargo tank if: (1) Low liquid level, motor current, or pump discharge pressure automatically shuts down power to the pump motor if the pump loses suction; (2) There is an audible and visual alarm at the cargo control station that actuates if the motor shuts down...

46 CFR 154.1010 - Electrical equipment in gas-dangerous space or zone.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... (c) A submerged cargo pump motor may be in a cargo tank if: (1) Low liquid level, motor current, or pump discharge pressure automatically shuts down power to the pump motor if the pump loses suction; (2) There is an audible and visual alarm at the cargo control station that actuates if the motor shuts down...

When Do Commercial Reactors Permanently Shut Down?

EIA Publications

2011-01-01

For those wishing to obtain current data, the following resources are available: U.S. reactors, go to the Energy Information Administration's nuclear reactor shutdown list. (Note: As of April 30, 2010, the last U.S. reactor to permanently shut down was Big Rock Point in 1997.) Foreign Reactors, go to the Power Reactor Information System (PRIS) on the International Atomic Energy Agency's website.

Plasma shut-down with fast impurity puff on ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Pautasso, G.; Fuchs, C. J.; Gruber, O.; Maggi, C. F.; Maraschek, M.; Pütterich, T.; Rohde, V.; Wittmann, C.; Wolfrum, E.; Cierpka, P.; Beck, M.; ASDEX Upgrade Team

2007-08-01

The massive injection of impurity gas into a plasma has been proved to reduce forces and localized thermal loads caused by disruptions in tokamaks. This mitigation system is routinely used on ASDEX Upgrade to shut down plasmas with a locked mode. The plasma response to impurity injection and the mechanism of reduction of the mechanical forces is discussed in the paper.

Symposium on "Shut Out Youth" (Strasbourg, France, October 25-30, 1987).

ERIC Educational Resources Information Center

Council of Europe, Strasbourg (France).

Many aspects of social policy affect the lives of shut out youth in Europe. The purpose of a symposium held at the European Youth Center (Strasbourg, France) was to draw attention to these issues and recommend ways to coordinate the social policies that affect the well-being of youth. The relevance of current policies was assessed in local,…

12 CFR 502.45 - What will happen if I do not pay my assessment on time?

Code of Federal Regulations, 2010 CFR

2010-01-01

...) If a savings and loan holding company fails to pay an assessment within 60 days of the date it is due... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What will happen if I do not pay my assessment... TREASURY ASSESSMENTS AND FEES Assessments Payment of Assessments § 502.45 What will happen if I do not pay...

Scientific Studies in Support of Shutting In the Macondo Well (Deepwater Horizon) Blowout, Gulf of Mexico (Invited)

NASA Astrophysics Data System (ADS)

Hickman, S.; Mooney, W. D.; Hsieh, P. A.; Enomoto, C.; Nelson, P. H.; McNutt, M.

2010-12-01

Scientists, engineers and managers from BP, other private companies, universities, government research labs and a broad spectrum of federal agencies have formed a unique cooperative working relationship in responding to the Macondo oil well (Deepwater Horizon) blowout. Among the many activities performed during this effort, U.S. Geological Survey personnel evaluated the potential geologic hazard of shutting in the Macondo well at the sea floor, and collectively decided, with others, the conditions under which it could be safely undertaken. These hazards included the possible loss of wellbore integrity under the anticipated high shut-in pressures, potentially leading to new pathways for hydrocarbon release to the Gulf of Mexico through upward hydraulic fracture propagation and/or soft sediment erosion initiating at possible leak points in the cemented casing. This hazard evaluation required analysis of 2D and 3D seismic surveys, seafloor bathymetry, pressure transient tests, geophysical well logs, in-situ stress (“leak-off”) tests and drilling data (e.g., mud logs) to assess the geological, hydrological and geomechanical conditions at and around the Macondo well. After the well was successfully capped and shut in by BP on July 15, a variety of monitoring practices were put into place to guard against further leaks into the Gulf. These monitoring activities included acquisition of wellhead pressure data, marine multi-channel seismic profiles, sea-floor and sea-surface sonar surveys (the latter using the NOAA RV/Pisces), and wellhead visual/acoustic monitoring. Scientists and engineers from BP, outside consultants, government agencies and the university community then worked together to continuously evaluate these data to ensure that the well remained safely shut in until reservoir pressures were suppressed (“killed”) with heavy drilling mud and the well was sealed with cement. This effort to shut in and then permanently seal the blown-out Macondo well has involved an unprecedented level of interaction, collaboration and coordination among scientists, engineers, managers and emergency response officials, and will hopefully lead to improved methodologies and approaches to assessing and then mitigating hazards posed by deepwater drilling.

Variation in Rhodopsin Kinase Expression Alters the Dim Flash Response Shut Off and the Light Adaptation in Rod Photoreceptors

PubMed Central

Sakurai, Keisuke; Young, Joyce E.; Kefalov, Vladimir J.; Khani, Shahrokh C.

2011-01-01

Purpose. Rod photoreceptors are exquisitely sensitive light detectors that function in dim light. The timely inactivation of their light responses is critical for the ability of rods to reliably detect and count photons. A key step in the inactivation of the rod transduction is the phosphorylation of the rod visual pigment, rhodopsin, catalyzed by G-protein-dependent receptor kinase 1 (GRK1). Absence of GRK1 greatly prolongs the photoreceptors' light response and enhances their susceptibility to degeneration. This study examined the light responses from mouse rods expressing various levels of GRK1 to evaluate how their function is modulated by rhodopsin inactivation. Methods. Transretinal and single-cell rod electrophysiological recordings were obtained from several strains of mice expressing GRK1 at 0.3- to 3-fold the wild-type levels. The effect of GRK1 expression level on the function of mouse rods was examined in darkness and during background adaptation. Results. Altering the expression of GRK1 from 0.3- to 3-fold that in wild-type rods had little effect on the single photon response amplitude. Notably, increasing the expression level of GRK1 accelerated the dim flash response shut off but had no effect on the saturated response shut off. Additionally, GRK1 excess abolished the acceleration of saturated responses shut off during light adaptation. Conclusions. These results demonstrate that rhodopsin inactivation can modulate the kinetics of recovery from dim light stimulation. More importantly, the ratio of rhodopsin kinase to its modulator recoverin appears critical for the proper adaptation of rods and the acceleration of their response shut off in background light. PMID:21474765

The Shutdown Dissociation Scale (Shut-D)

PubMed Central

Schalinski, Inga; Schauer, Maggie; Elbert, Thomas

2015-01-01

The evolutionary model of the defense cascade by Schauer and Elbert (2010) provides a theoretical frame for a short interview to assess problems underlying and leading to the dissociative subtype of posttraumatic stress disorder. Based on known characteristics of the defense stages “fright,” “flag,” and “faint,” we designed a structured interview to assess the vulnerability for the respective types of dissociation. Most of the scales that assess dissociative phenomena are designed as self-report questionnaires. Their items are usually selected based on more heuristic considerations rather than a theoretical model and thus include anything from minor dissociative experiences to major pathological dissociation. The shutdown dissociation scale (Shut-D) was applied in several studies in patients with a history of multiple traumatic events and different disorders that have been shown previously to be prone to symptoms of dissociation. The goal of the present investigation was to obtain psychometric characteristics of the Shut-D (including factor structure, internal consistency, retest reliability, predictive, convergent and criterion-related concurrent validity). A total population of 225 patients and 68 healthy controls were accessed. Shut-D appears to have sufficient internal reliability, excellent retest reliability, high convergent validity, and satisfactory predictive validity, while the summed score of the scale reliably separates patients with exposure to trauma (in different diagnostic groups) from healthy controls. The Shut-D is a brief structured interview for assessing the vulnerability to dissociate as a consequence of exposure to traumatic stressors. The scale demonstrates high-quality psychometric properties and may be useful for researchers and clinicians in assessing shutdown dissociation as well as in predicting the risk of dissociative responding. PMID:25976478

Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.

PubMed

Sakurai, Keisuke; Young, Joyce E; Kefalov, Vladimir J; Khani, Shahrokh C

2011-08-29

Rod photoreceptors are exquisitely sensitive light detectors that function in dim light. The timely inactivation of their light responses is critical for the ability of rods to reliably detect and count photons. A key step in the inactivation of the rod transduction is the phosphorylation of the rod visual pigment, rhodopsin, catalyzed by G-protein-dependent receptor kinase 1 (GRK1). Absence of GRK1 greatly prolongs the photoreceptors' light response and enhances their susceptibility to degeneration. This study examined the light responses from mouse rods expressing various levels of GRK1 to evaluate how their function is modulated by rhodopsin inactivation. Transretinal and single-cell rod electrophysiological recordings were obtained from several strains of mice expressing GRK1 at 0.3- to 3-fold the wild-type levels. The effect of GRK1 expression level on the function of mouse rods was examined in darkness and during background adaptation. Altering the expression of GRK1 from 0.3- to 3-fold that in wild-type rods had little effect on the single photon response amplitude. Notably, increasing the expression level of GRK1 accelerated the dim flash response shut off but had no effect on the saturated response shut off. Additionally, GRK1 excess abolished the acceleration of saturated responses shut off during light adaptation. These results demonstrate that rhodopsin inactivation can modulate the kinetics of recovery from dim light stimulation. More importantly, the ratio of rhodopsin kinase to its modulator recoverin appears critical for the proper adaptation of rods and the acceleration of their response shut off in background light.

The impact of reducing car weight on global emissions: the future fleet in Great Britain

NASA Astrophysics Data System (ADS)

Serrenho, André Cabrera; Norman, Jonathan B.; Allwood, Julian M.

2017-05-01

Current European policies define targets for future direct emissions of new car sales that foster a fast transition to electric drivetrain technologies. However, these targets do not consider the emissions produced in electricity generation and material production, and therefore fail to incentivise car manufacturers to consider the benefits of vehicle weight reduction. In this paper, we examine the potential benefits of limiting the average weight and altering the material composition of new cars in terms of global greenhouse gas emissions produced during the use phase, electricity generation and material production. We anticipate the emissions savings for the future car fleet in Great Britain until 2050 for various alternative futures, using a dynamic material flow analysis of ferrous metals and aluminium, and considering an evolving demand for car use. The results suggest that fostering vehicle weight reduction could produce greater cumulative emissions savings by 2050 than those obtained by incentivising a fast transition to electric drivetrains, unless there is an extreme decarbonization of the electricity grid. Savings promoted by weight reduction are immediate and do not depend on the pace of decarbonization of the electricity grid. Weight reduction may produce the greatest savings when mild steel in the car body is replaced with high-strength steel. This article is part of the themed issue 'Material demand reduction'.

International energy indicators

NASA Astrophysics Data System (ADS)

Bauer, E. K.

1981-02-01

Extensive data are compiled for energy on the international scene and for the US. Data included are: world crude oil production, 1975 to date; Iran: crude oil capacity, production, and shut-in, 1974 to date; Saudi Arabia: crude oil capacity, production, and shut-in, 1974 to date; OPEC (Ex-Iran and Saudi Arabia): capacity, production, and shut-in, 1974 to date; oil stocks: Free World, US, Japan, and Europe (landed), 1973 to date; petroleum consumption by industrial countries, 1973 to date; USSR crude oil production, 1974 to date; Free World and US nuclear generation capacity, 1973 to date. Data are supplied specifically for the US on US gross imports of crude oil and products, 1973 to date; landed cost of Saudi crude in current and 1974 dollars; US trade in bituminous coal, 1973 to date; summary of US merchandise trade, 1976 to date; and energy/GNP ratio.

Validating induced seismicity forecast models—Induced Seismicity Test Bench

NASA Astrophysics Data System (ADS)

Király-Proag, Eszter; Zechar, J. Douglas; Gischig, Valentin; Wiemer, Stefan; Karvounis, Dimitrios; Doetsch, Joseph

2016-08-01

Induced earthquakes often accompany fluid injection, and the seismic hazard they pose threatens various underground engineering projects. Models to monitor and control induced seismic hazard with traffic light systems should be probabilistic, forward-looking, and updated as new data arrive. In this study, we propose an Induced Seismicity Test Bench to test and rank such models; this test bench can be used for model development, model selection, and ensemble model building. We apply the test bench to data from the Basel 2006 and Soultz-sous-Forêts 2004 geothermal stimulation projects, and we assess forecasts from two models: Shapiro and Smoothed Seismicity (SaSS) and Hydraulics and Seismics (HySei). These models incorporate a different mix of physics-based elements and stochastic representation of the induced sequences. Our results show that neither model is fully superior to the other. Generally, HySei forecasts the seismicity rate better after shut-in but is only mediocre at forecasting the spatial distribution. On the other hand, SaSS forecasts the spatial distribution better and gives better seismicity rate estimates before shut-in. The shut-in phase is a difficult moment for both models in both reservoirs: the models tend to underpredict the seismicity rate around, and shortly after, shut-in.

Comparing shut-down strategies for proton exchange membrane fuel cells

NASA Astrophysics Data System (ADS)

Oyarce, Alejandro; Zakrisson, Erik; Ivity, Matthew; Lagergren, Carina; Ofstad, Axel Baumann; Bodén, Andreas; Lindbergh, Göran

2014-05-01

Application of system strategies for mitigating carbon corrosion of the catalyst support in proton exchange fuel cells (PEMFCs) is a requirement for PEMFC systems, especially in the case of systems for transport application undergoing thousands of start-ups and shut-downs (SU/SD) during its lifetime. This study compares several of the most common shut-down strategies for 1100 cycles SU/SD cycles at 70 °C and 80% RH using commercially available fuel cell components. Each cycle simulates a prolonged shut-down, i.e. finishing each cycle with air filled anode and cathode. Furthermore, all start-ups are unprotected, i.e. introducing the H2 rich gas into an air filled anode. Finally, each cycle also includes normal fuel cell operation at 0.5 A cm-2 using synthetic reformate/air. H2 purge of the cathode and O2 consumption using a load were found to be the most effective strategies. The degradation rate using the H2 purge strategy was 23 μV cycle-1 at 0.86 A cm-2 using H2 and air at the anode and cathode, respectively. This degradation rate may be regarded as a generally low value, especially considering that this value also includes the degradation rate caused by unprotected start-ups.

Evolution of the shut-off steps of vertebrate phototransduction

PubMed Central

Patel, Hardip R.; Chuah, Aaron

2018-01-01

Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication. In this study, we determine the molecular phylogeny of the proteins underlying the shut-off steps of phototransduction in the agnathan and jawed vertebrate lineages. For the G-protein receptor kinases (GRKs), the GRK1 and GRK7 divisions arose prior to the divergence of tunicates, with further expansion during the two rounds of whole-genome duplication (2R); subsequently, jawed and agnathan vertebrates retained different subsets of three isoforms of GRK. For the arrestins, gene expansion occurred during 2R. Importantly, both for GRKs and arrestins, the respective rod isoforms did not emerge until the second round of 2R, just prior to the separation of jawed and agnathan vertebrates. For the triplet of proteins mediating shut-off of the G-protein transducin, RGS9 diverged from RGS11, probably at the second round of 2R, whereas Gβ5 and R9AP appear not to have undergone 2R expansion. Overall, our analysis provides a description of the duplications and losses of phototransduction shut-off genes that occurred during the transition from a chordate with only cone-like photoreceptors to an ancestral vertebrate with both cone- and rod-like photoreceptors. PMID:29321241

Pressure Analysis

NASA Technical Reports Server (NTRS)

1990-01-01

FluiDyne Engineering Corporation, Minneapolis, MN is one of the world's leading companies in design and construction of wind tunnels. In its designing work, FluiDyne uses a computer program called GTRAN. With GTRAN, engineers create a design and test its performance on the computer before actually building a model; should the design fail to meet criteria, the system or any component part can be redesigned and retested on the computer, saving a great deal of time and money.

Quantitative modeling of the molecular steps underlying shut-off of rhodopsin activity in rod phototransduction

PubMed Central

Kraft, Timothy W.

2016-01-01

Purpose To examine the predictions of alternative models for the stochastic shut-off of activated rhodopsin (R*) and their implications for the interpretation of experimentally recorded single-photon responses (SPRs) in mammalian rods. Theory We analyze the transitions that an activated R* molecule undergoes as a result of successive phosphorylation steps and arrestin binding. We consider certain simplifying cases for the relative magnitudes of the reaction rate constants and derive the probability distributions for the time to arrestin binding. In addition to the conventional model in which R* catalytic activity declines in a graded manner with successive phosphorylations, we analyze two cases in which the activity is assumed to occur not via multiple small steps upon each phosphorylation but via a single large step. We refer to these latter two cases as the binary R* shut-off and three-state R* shut-off models. Methods We simulate R*’s stochastic reactions numerically for the three models. In the simplifying cases for the ratio of rate constants in the binary and three-state models, we show that the probability distribution of the time to arrestin binding is accurately predicted. To simulate SPRs, we then integrate the differential equations for the downstream reactions using a standard model of the rod outer segment that includes longitudinal diffusion of cGMP and Ca2+. Results Our simulations of SPRs in the conventional model of graded shut-off of R* conform closely to the simulations in a recent study. However, the gain factor required to account for the observed mean SPR amplitude is higher than can be accounted for from biochemical experiments. In addition, a substantial minority of the simulated SPRs exhibit features that have not been reported in published experiments. Our simulations of SPRs using the model of binary R* shut-off appear to conform closely to experimental results for wild type (WT) mouse rods, and the required gain factor conforms to biochemical expectations. However, for the arrestin knockout (Arr−/−) phenotype, the predictions deviated from experimental findings and led us to invoke a low-activity state that R* enters before arrestin binding. Our simulations of this three-state R* shut-off model are very similar to those of the binary model in the WT case but are preferred because they appear to accurately predict the mean SPRs for four mutant phenotypes, Arr+/−, Arr−/−, GRK1+/−, and GRK1−/−, in addition to the WT phenotype. When we additionally treated the formation and shut-off of activated phosphodiesterase (E*) as stochastic, the simulated SPRs appeared even more similar to real SPRs, and there was very little change in the ensemble mean and standard deviation or in the amplitude distribution. Conclusions We conclude that the conventional model of graded reduction in R* activity through successive phosphorylation steps appears to be inconsistent with experimental results. Instead, we find that two variants of a model in which R* activity initially remains high and then declines abruptly after several phosphorylation steps appears capable of providing a better description of experimentally measured SPRs. PMID:27375353

Do HMO and its for-profit expansion jeopardize the survival of hospital safety net services?

PubMed

Shen, Yu-Chu

2009-03-01

This study examines the effect of health maintenance organizations (HMOs) and for-profit HMO share on the survival of safety net services in hospitals between 1990 and 2004. The primary data sources are the American Hospital Association Annual Surveys, the Medicare hospital cost reports, and the HMO enrollment and ownership data from Interstudy. I analyze the risks of shutting down each safety net service separately using the proportional hazard models. I find that the risks of shutting down hospital safety net services do not vary by different levels of overall HMO penetration. However, conditional on the overall HMO penetration level, increasing for-profit presence of HMO does increase the risks of shutting down several safety net services. Policies evaluating the for-profit expansion or ownership conversion of health plans should take this potential adverse effect into consideration.

Designing effective incentives for energy conservation in the public sector

NASA Astrophysics Data System (ADS)

Drezner, Jeffrey Alan

Understanding why government officials behave in certain ways under particular circumstances is an important theme in political science. This research explores the design of policies and incentives targeted at public sector officials, in particular the use of market based policy tools in a non-market environment, and the influence of that organizational environment on the effectiveness of the policy. The research examines the case of Department of Defense (DoD) facility energy management. DoD energy policy includes a provision for the retention of savings generated by conservation activities: two-thirds of the savings is retained at the installation generating the savings, half to used for further investment in energy conservation, and half to be used for general morale, welfare, and recreation activities. This policy creates a financial incentive for installation energy managers to establish higher quality and more active conservation programs. A formal written survey of installation energy managers within DoD was conducted, providing data to test hypotheses regarding policy effectiveness and factors affecting policy implementation. Additionally, two detailed implementation case studies were conducted in order to gain further insights. Results suggest that policy design needs to account for the environment within which the policy will be implemented, particularly organizational culture and standard operating procedures. The retention of savings policy failed to achieve its intended outcome---retention of savings for re-investment in energy conservation---because the role required of the financial management community was outside its normal mode of operation and interests and the budget process for allocating resources did not include a mechanism for retention of savings. The policy design did not adequately address these start-up barriers to implementation. This analysis has shown that in order for retention of savings, or similar policies based on market-type mechanisms, to be effective in the public sector context, the required cultural changes and appropriate implementing mechanisms must be provided for in the policy design.

Evolution of the shut-off steps of vertebrate phototransduction.

PubMed

Lamb, Trevor D; Patel, Hardip R; Chuah, Aaron; Hunt, David M

2018-01-01

Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication. In this study, we determine the molecular phylogeny of the proteins underlying the shut-off steps of phototransduction in the agnathan and jawed vertebrate lineages. For the G-protein receptor kinases (GRKs), the GRK1 and GRK7 divisions arose prior to the divergence of tunicates, with further expansion during the two rounds of whole-genome duplication (2R); subsequently, jawed and agnathan vertebrates retained different subsets of three isoforms of GRK. For the arrestins, gene expansion occurred during 2R. Importantly, both for GRKs and arrestins, the respective rod isoforms did not emerge until the second round of 2R, just prior to the separation of jawed and agnathan vertebrates. For the triplet of proteins mediating shut-off of the G-protein transducin, RGS9 diverged from RGS11, probably at the second round of 2R, whereas Gβ5 and R9AP appear not to have undergone 2R expansion. Overall, our analysis provides a description of the duplications and losses of phototransduction shut-off genes that occurred during the transition from a chordate with only cone-like photoreceptors to an ancestral vertebrate with both cone- and rod-like photoreceptors. © 2018 The Authors.

Testing simulation and structural models with applications to energy demand

NASA Astrophysics Data System (ADS)

Wolff, Hendrik

2007-12-01

This dissertation deals with energy demand and consists of two parts. Part one proposes a unified econometric framework for modeling energy demand and examples illustrate the benefits of the technique by estimating the elasticity of substitution between energy and capital. Part two assesses the energy conservation policy of Daylight Saving Time and empirically tests the performance of electricity simulation. In particular, the chapter "Imposing Monotonicity and Curvature on Flexible Functional Forms" proposes an estimator for inference using structural models derived from economic theory. This is motivated by the fact that in many areas of economic analysis theory restricts the shape as well as other characteristics of functions used to represent economic constructs. Specific contributions are (a) to increase the computational speed and tractability of imposing regularity conditions, (b) to provide regularity preserving point estimates, (c) to avoid biases existent in previous applications, and (d) to illustrate the benefits of our approach via numerical simulation results. The chapter "Can We Close the Gap between the Empirical Model and Economic Theory" discusses the more fundamental question of whether the imposition of a particular theory to a dataset is justified. I propose a hypothesis test to examine whether the estimated empirical model is consistent with the assumed economic theory. Although the proposed methodology could be applied to a wide set of economic models, this is particularly relevant for estimating policy parameters that affect energy markets. This is demonstrated by estimating the Slutsky matrix and the elasticity of substitution between energy and capital, which are crucial parameters used in computable general equilibrium models analyzing energy demand and the impacts of environmental regulations. Using the Berndt and Wood dataset, I find that capital and energy are complements and that the data are significantly consistent with duality theory. Both results would not necessarily be achieved using standard econometric methods. The final chapter "Daylight Time and Energy" uses a quasi-experiment to evaluate a popular energy conservation policy: we challenge the conventional wisdom that extending Daylight Saving Time (DST) reduces energy demand. Using detailed panel data on half-hourly electricity consumption, prices, and weather conditions from four Australian states we employ a novel 'triple-difference' technique to test the electricity-saving hypothesis. We show that the extension failed to reduce electricity demand and instead increased electricity prices. We also apply the most sophisticated electricity simulation model available in the literature to the Australian data. We find that prior simulation models significantly overstate electricity savings. Our results suggest that extending DST will fail as an instrument to save energy resources.

Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.

PubMed

Nicastro, Raffaele; Tripodi, Farida; Gaggini, Marco; Castoldi, Andrea; Reghellin, Veronica; Nonnis, Simona; Tedeschi, Gabriella; Coccetti, Paola

2015-10-09

In eukaryotes, nutrient availability and metabolism are coordinated by sensing mechanisms and signaling pathways, which influence a broad set of cellular functions such as transcription and metabolic pathways to match environmental conditions. In yeast, PKA is activated in the presence of high glucose concentrations, favoring fast nutrient utilization, shutting down stress responses, and boosting growth. On the contrary, Snf1/AMPK is activated in the presence of low glucose or alternative carbon sources, thus promoting an energy saving program through transcriptional activation and phosphorylation of metabolic enzymes. The PKA and Snf1/AMPK pathways share common downstream targets. Moreover, PKA has been reported to negatively influence the activation of Snf1/AMPK. We report a new cross-talk mechanism with a Snf1-dependent regulation of the PKA pathway. We show that Snf1 and adenylate cyclase (Cyr1) interact in a nutrient-independent manner. Moreover, we identify Cyr1 as a Snf1 substrate and show that Snf1 activation state influences Cyr1 phosphorylation pattern, cAMP intracellular levels, and PKA-dependent transcription. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

The impact of reducing car weight on global emissions: the future fleet in Great Britain

PubMed Central

Norman, Jonathan B.; Allwood, Julian M.

2017-01-01

Current European policies define targets for future direct emissions of new car sales that foster a fast transition to electric drivetrain technologies. However, these targets do not consider the emissions produced in electricity generation and material production, and therefore fail to incentivise car manufacturers to consider the benefits of vehicle weight reduction. In this paper, we examine the potential benefits of limiting the average weight and altering the material composition of new cars in terms of global greenhouse gas emissions produced during the use phase, electricity generation and material production. We anticipate the emissions savings for the future car fleet in Great Britain until 2050 for various alternative futures, using a dynamic material flow analysis of ferrous metals and aluminium, and considering an evolving demand for car use. The results suggest that fostering vehicle weight reduction could produce greater cumulative emissions savings by 2050 than those obtained by incentivising a fast transition to electric drivetrains, unless there is an extreme decarbonization of the electricity grid. Savings promoted by weight reduction are immediate and do not depend on the pace of decarbonization of the electricity grid. Weight reduction may produce the greatest savings when mild steel in the car body is replaced with high-strength steel. This article is part of the themed issue ‘Material demand reduction’. PMID:28461428

The impact of reducing car weight on global emissions: the future fleet in Great Britain.

PubMed

Serrenho, André Cabrera; Norman, Jonathan B; Allwood, Julian M

2017-06-13

Current European policies define targets for future direct emissions of new car sales that foster a fast transition to electric drivetrain technologies. However, these targets do not consider the emissions produced in electricity generation and material production, and therefore fail to incentivise car manufacturers to consider the benefits of vehicle weight reduction. In this paper, we examine the potential benefits of limiting the average weight and altering the material composition of new cars in terms of global greenhouse gas emissions produced during the use phase, electricity generation and material production. We anticipate the emissions savings for the future car fleet in Great Britain until 2050 for various alternative futures, using a dynamic material flow analysis of ferrous metals and aluminium, and considering an evolving demand for car use. The results suggest that fostering vehicle weight reduction could produce greater cumulative emissions savings by 2050 than those obtained by incentivising a fast transition to electric drivetrains, unless there is an extreme decarbonization of the electricity grid. Savings promoted by weight reduction are immediate and do not depend on the pace of decarbonization of the electricity grid. Weight reduction may produce the greatest savings when mild steel in the car body is replaced with high-strength steel.This article is part of the themed issue 'Material demand reduction'. © 2017 The Authors.

Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution.

PubMed

Gumbs, Pearl D; Verschuren, W M Monique; Souverein, Patrick C; Mantel-Teeuwisse, Aukje K; de Wit, G Ardine; de Boer, Anthonius; Klungel, Olaf H

2007-11-01

To assess the potential annual savings due to generic and therapeutic substitution of statin therapy for the general Dutch population, taking the patients medical history into account. We conducted a population-based costing study using the PHARMO Record Linkage System (RLS). PHARMO RLS contains drug dispensing records from a representative sample of pharmacies located in more than 50 regions in the Netherlands. We selected all statin users in the database since 2003. The cost-savings of generic substitution of statin therapy for all simvastatin and pravastatin users, and of therapeutic substitution of statin therapy for other statin users were calculated. Substituting current users and new users of statins were considered separately. Therapeutic substitution was based on the medical history of the individual patient. Patients were only substituted if there was an appropriate substitute available. The appropriateness of substitution was based on drug-drug interactions between statins and possible comedication and the availability of an equipotent alternative. Substituting (generic and therapeutic) statin therapy for all current users would lead to potential annual savings of approximately 87 million euros. Substituting (generic and therapeutic) all starters on statin therapy would lead to potential annual savings of around 51 million euros. In the case of generic substitution only, the potential annual savings for all current simvastatin and pravastatin users would be 2.4 million euros and for the new users about 1.8 million euros. From an economic point of view, society could gain a lot from substituting statin therapy, especially from therapeutic substitution.

Specification, Measurement, and Control of Electrical Switching Transients

NASA Technical Reports Server (NTRS)

Javor, K.

1999-01-01

There have been several instances of susceptibility to switching transients. The Space Shuttle Spacelab Remote Acquisition Unit (RAU-A standard interface between Spacelab payloads and the Shuttle communications system) will shut down if the input 28 Vdc bus drops below 22 volts for more than 80 gs. Although a MIL-STD-461 derivative CS06 requirement was levied on the RAU, it failed to find this susceptibility. A heavy payload on one aircraft sags the 28 volt bus below 20 volts for milliseconds. Dc-dc converters have an operating voltage. A typical 28 Vdc-to-5 Vdc converter operates within tolerance when input potential is between 17-40 Vdc, A hold-up capacitor can be used to extend the time this range is presented to the convener when the line potential sags or surges outside this range. The designer must know the range of normal transients in order to choose the correct value of hold-up. This report describes the phenomena of electrical power bus transients induced by the switching of loads both on and off the bus, and control thereof.

Advanced wind turbine with lift cancelling aileron for shutdown

DOEpatents

Coleman, Clint; Juengst, Theresa M.; Zuteck, Michael D.

1996-06-18

An advanced aileron configuration for wind turbine rotors featuring an independent, lift generating aileron connected to the rotor blade. The aileron has an airfoil profile which is inverted relative to the airfoil profile of the main section of the rotor blade. The inverted airfoil profile of the aileron allows the aileron to be used for strong positive control of the rotation of the rotor while deflected to angles within a control range of angles. The aileron functions as a separate, lift generating body when deflected to angles within a shutdown range of angles, generating lift with a component acting in the direction opposite the direction of rotation of the rotor. Thus, the aileron can be used to shut down rotation of the rotor. The profile of the aileron further allows the center of rotation to be located within the envelope of the aileron, at or near the centers of pressure and mass of the aileron. The location of the center of rotation optimizes aerodynamically and gyroscopically induced hinge moments and provides a fail safe configuration.

Possible consequences of operation with KIVN fuel elements in K Zircaloy process tubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, P.A.

1963-08-06

From considerations of the results of experimental simulations of non-axial placement of fuel elements in process tubes and in-reactor experience, it is concluded that the ultimate outcome of a charging error which results in operation with one or more unsupported fuel elements in a K Zircaloy-2 process tube would be multiple fuel failure and failure of the process tube. The outcome of the accident is determined by the speed with which the fuel failure is detected and the reactor is shut down. The release of fission products would be expected to be no greater than that which has occurred followingmore » severe fuel failure incidents. The highest probability for fission product release occurs during the discharge of failed fuel elements, when a small fraction of the exposed uranium of the fuel element may be oxidized when exposed to air before the element falls into the water-filled discharge chute. The confinement and fog spray facilities were installed to reduce the amount of fission products which might escape from the reactor building after such an event.« less

Statistical Performance Evaluation Of Soft Seat Pressure Relief Valves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, Stephen P.; Gross, Robert E.

2013-03-26

Risk-based inspection methods enable estimation of the probability of failure on demand for spring-operated pressure relief valves at the United States Department of Energy's Savannah River Site in Aiken, South Carolina. This paper presents a statistical performance evaluation of soft seat spring operated pressure relief valves. These pressure relief valves are typically smaller and of lower cost than hard seat (metal to metal) pressure relief valves and can provide substantial cost savings in fluid service applications (air, gas, liquid, and steam) providing that probability of failure on demand (the probability that the pressure relief valve fails to perform its intendedmore » safety function during a potentially dangerous over pressurization) is at least as good as that for hard seat valves. The research in this paper shows that the proportion of soft seat spring operated pressure relief valves failing is the same or less than that of hard seat valves, and that for failed valves, soft seat valves typically have failure ratios of proof test pressure to set pressure less than that of hard seat valves.« less

Reducing risk in maternity by optimising teamwork and leadership: an evidence-based approach to save mothers and babies.

PubMed

Cornthwaite, Katie; Edwards, Sian; Siassakos, Dimitrios

2013-08-01

Poor teamwork results in preventable morbidity and mortality for mothers and babies. Suboptimal communication and lack of leadership cost not only lives but also money that is diverted from clinical care to insurance and litigation. Avoidable harm is usually not the result of staff failing their duty of care, it is the result of poor training failing hard-worked staff. A few simple teamwork and leadership behaviours can make a huge difference to outcome and experience for women and their companions, yet they are often missing from maternity care. Recent research has identified the problems and solutions, including the best way to train maternity teams to make a palpable difference. We describe simple yet evidence-based methods to improve teams and leaders. Copyright © 2013 Elsevier Ltd. All rights reserved.

Aviation Proof of Concept: The Transition of Marine Corps Aviation Maintenance Computer Assets and Systems into the Navy Marine Corps Intranet

DTIC Science & Technology

2010-03-01

Blackberry Services Increment 1 SLAPC: 103.8 SERVICE NAME: HELP DESK SLA: 104 Performance Category: Average Speed of Answer - Telephone Calls...Category: Blackberry Services Increment 1 SLAPC: 103.8 SERVICE NAME: HELP DESK SLA: 104 Performance Category: Average Speed of Answer - Telephone...legacy VPNs for existing tunnels , until MCNOSC agrees to shut down of legacy B-1’s. o Shut down of legacy B-1’s will transfer VPN’s tunnels to

The Shock and Vibration Digest. Volume 9, Number 2. February 1977

DTIC Science & Technology

1977-02-01

15.00. Orders may be forwarded at Y1 -any time , in any form, to SVIC, Code 8404, Naval Research Laborotory, , Washington, D.C., 20375. Issuance of...new technology allows engi,;oers to determine shut-down times for reasons of safety and to avoid loss of productivity. No longer does a machine have to...likely become practical. Machine prognosis will allow the engineer to determine the most advantageous time for shut down. It will thus be possible to

Homebound Learning Opportunities: reaching out to older shut-ins and their caregivers.

PubMed

Penning, M; Wasyliw, D

1992-10-01

Homebound Learning Opportunities (HLO) represents an innovative health promotion and educational outreach service for homebound older adults and their caregivers. It provides over 125 topics for individualized learning programs delivered to participants in their own places of residence, an audiovisual lending library, educational television programming, and a peer counseling service. Shut-ins are recruited as instructors and as participants in service projects that benefit the greater community. Preliminary assessments reveal high levels of participation and satisfaction with the program.

SPRING DRIVEN ACTUATING MECHANISM FOR NUCLEAR REACTOR CONTROL

DOEpatents

Bevilacqua, F.; Uecker, D.F.; Groh, E.F.

1962-01-23

l962. rod in a nuclear reactor to shut it down. The control rod or an extension thereof is wound on a drum as it is withdrawn from the reactor. When an emergency occurs requiring the reactor to be shut down, the drum is released so as to be free to rotate, and the tendency of the control rod or its extension coiled on the drum to straighten itself is used for quickly returning the control rod to the reactor. (AEC)

Design and Optimization of Slot Aluminum Alloy Connectors of Photovoltaics Applied to High-rise Building Facades

NASA Astrophysics Data System (ADS)

Liang, Ya-Wei; Zhang, Hong-Mei; Dong, Jin-Zhi; Shi, Zhen-Hua

2016-05-01

Building Integrated Photovoltaic (BIPV) is a resort to save energy and reduce heat gain of buildings, utilize new and renewable energy, solve environment problems and alleviate electricity shortage in large cities. The area needed to generate power makes facade integrated photovoltaic panel a superb choice, especially in high-rise buildings. Numerous scholars have hitherto explored Building Facade Integrated Photovoltaic, however, focusing mainly on thermal performance, which fails to ensure seismic safety of high-rise buildings integrated photovoltaic. Based on connecting forms of the glass curtain wall, a connector jointing photovoltaic panel and facade was designed, which underwent loading position and size optimization. Static loading scenarios were conducted to test and verify the connector's mechanical properties under gravity and wind loading by means of HyperWorks. Compared to the unoptimized design, the optimized one saved material and managed to reduce maximum deflection by 74.64%.

Countering Violent Extremism Policy in the United States: Are CVE Programs in America Effectively Mitigating the Threat of Homegrown Violent Extremism

DTIC Science & Technology

2017-12-01

anger and violence of those groups improperly judged as “inferior,” especially when a society fails to instill a sense of communal values in the overall...more likely when people experience ‘collective strains’ that are: 1. High in Magnitude with civilians affected; 2. Unjust; 3. Inflicted by... American efforts to counter violent extremism, “if properly implemented, can help sway young people from radicalizing, thereby saving lives and enabling

Paradigm shift: Can TQM save DOD's procurement process?

NASA Astrophysics Data System (ADS)

Romeo, Ross V.

1992-11-01

The Department of Defense's (DOD) ambitious introduction of total quality management (TQM) will fail, unless they change their paradigm and reengineer how they do business. TQM implementation in the defense department and possibilities for reengineering DOD's management structure were investigated. This paper uses a case study to investigate DOD's procurement efficiency and effectiveness with information technology. The findings show DOD is faced with its greatest challenge since WWII in meeting the rapidly evolving environment of the 1990s and the 21st century.

The Development of High Order Methods for Real World Applications

DTIC Science & Technology

2015-12-03

current method has been applied to aerodynamic problems. Numerical tests show that significant savings in the number of DOFs can be achieved through... current element Vi, and the normal flux Fn(Qi) at the interface is Fn(Qi) = ~F (Qi) · ~n. In order to eliminate the test function, the boundary integral...provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently

The Development of High-Order Methods for Real World Applications

DTIC Science & Technology

2015-12-03

current method has been applied to aerodynamic problems. Numerical tests show that significant savings in the number of DOFs can be achieved through... current element Vi, and the normal flux Fn(Qi) at the interface is Fn(Qi) = ~F (Qi) · ~n. In order to eliminate the test function, the boundary integral...provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently

Increasing of the lifetime of large forging dies by repairwelding

NASA Astrophysics Data System (ADS)

Duchek, M.; Koukolikova, M.; Kotous, J.; Majer, M.

2018-02-01

Repair welding is often used for rebuilding discarded or failed forging dies. It saves the cost of new tools. Increased useful life of repaired dies is another motivation for repair welding. This article focuses on the development of new filler materials for this purpose. The main goal was to prolong the life of tools of DIN 1.2714 material. Filler wires of two chemistries were made and several samples were experimentally welded. Metallographic and tribological analyses were carried out.

Data Compression With Application to Geo-Location

DTIC Science & Technology

2010-08-01

wireless sensor network requires the estimation of time-difference-of-arrival (TDOA) parameters using data collected by a set of spatially separated sensors. Compressing the data that is shared among the sensors can provide tremendous savings in terms of the energy and transmission latency. Traditional MSE and perceptual based data compression schemes fail to accurately capture the effects of compression on the TDOA estimation task; therefore, it is necessary to investigate compression algorithms suitable for TDOA parameter estimation. This thesis explores the

Rad Resilient City: a preparedness checklist to save lives following a nuclear detonation.

PubMed

Schoch-Spana, Monica

2013-11-01

The Rad Resilient City Checklist is a local planning tool that can help save tens of thousands of lives following a nuclear detonation. If prevention of nuclear terrorism fails, then reducing exposure to radioactive fallout is the intervention that can save the most lives following a nuclear detonation. Yet, most Americans are not familiar with correct safety measures against fallout, and many believe that nothing can be done to reduce the suffering and death inflicted by a nuclear attack. Moreover, cities have no checklist on how to prepare the emergency management infrastructure and the larger population for this hazard, despite hundreds of pages of useful guidance from the federal government and radiation professional organizations. The Rad Resilient City Checklist reverses this situation by converting the latest federal guidance and technical reports into clear, actionable steps for communities to take to protect their residents from exposure to radioactive fallout. The checklist reflects the shared judgment of the Nuclear Resilience Expert Advisory Group, a national panel led by the Center for Biosecurity and comprised of government decision makers, scientific experts, emergency responders, and leaders from business, volunteer, and community sectors.

Nifedipine versus fenoterol in the management of preterm labor: a randomized, multicenter clinical study.

PubMed

Valdés, E; Salinas, H; Toledo, V; Lattes, K; Cuellar, E; Perucca, E; Diaz, R; Montecinos, F; Reyes, A

2012-01-01

To compare the efficacy of nifedipine and fenoterol in the management of threatened preterm labor (TPL). A randomized and multicenter study assessing the tocolytic effect of nifedipine versus fenoterol in patients admitted to the participating maternity units with a diagnosis of TPL and a cost-savings study for economic assessment. For a power of 80% and an α error equal to 0.05, 132 consecutive patients were recruited during the study period; 66 patients were assigned to each group. A χ(2) analysis and a mean differences test were performed according to variable types and survival curves per intention-to-treat. Demographics were similar in both groups. The latency period was similar in both groups (26.7 vs. 25.6; p = 0.3). There were no differences in the results obtained. Nifedipine failed more frequently to obtain tocolysis when used as a first-line agent (80 vs. 90%, p = 0.0001). The group treated with fenoterol showed more drug adverse events (57.8 vs. 19.0%, p = 0.0001). The economic assessment did not evidence a significant difference in terms of cost savings between groups treated with either drug. The present study failed to demonstrate either clinical or economic superiority of any of the two drugs used in TPL management. The highest failure percentage of nifedipine when used as a first-line agent should encourage further research. Copyright © 2012 S. Karger AG, Basel.

Financial impact of radiological reports on medical-legal evaluation of compensation for meniscal lesions.

PubMed

Lelario, M; Ciuffreda, P; Lupo, P; Bristogiannis, C; Vinci, R; Stoppino, L P; De Filippo, M; Macarini, L

2013-08-01

To evaluate any discrepancy between radiological reports for clinical purposes and for medicolegal purposes and to quantify its economic impact on repayments made by private insurance companies for meniscal injuries of the knee. The medical records obtained pertaining to 108 knee injury patients (mean age 43.3 years) assessed over a period of 12 months were analysed. Clinical medical reports, aimed at assessing the lesion, and medicolegal reports, drawn up with a view to quantifying compensation, were compared. Unlike reports for clinical purposes in reports for medicolegal purposes, in the evaluation of meniscal lesions, in addition to morphological features of lesions, chronological, topographical, severity and exclusion criteria were applied. To estimate the economic impact resulting from the biological damage, we consulted an actuarial table based on the 9-point minor incapacity classification system. Meniscal lesions not compatible with a traumatic event and therefore not eligible for an insurance payout were found in 56 patients. Of these, 37 failed exclusion criteria, while 19 failed to meet chronological criteria. This difference resulted in a reduction in compensation made by private insurance companies with savings estimated with a saving between euro 203,715.41 and euro 622,315.39. The use of a clinical report for medicolegal purposes can be a source of valuation error, as chronological and/or dynamic information regarding the trauma mechanism may be lacking. Therefore, the use of a full radiological appraisal allows a better damage's assessment and an adequate compensation for injuries.

Water-saving interventions assessment framework: an application for the Urmia Lake Restoration Program

NASA Astrophysics Data System (ADS)

Shadkam, Somayeh; Oel, Pieter; Kabat, Pavel; Ludwig, Fulco

2017-04-01

Increasing water demand often results in unsustainable water use leaving insufficient amounts of water for sustaining natural environments. Therefore, to save natural resources water-saving interventions have been introduced to the environmental policy agenda in many (semi)-arid regions. Many policies, however, have failed reaching their objectives to increase water availability for the environment. This calls for a comprehensive tool to assess water-saving policies. Therefore, this study introduces a constructive framework to assess the policies by estimating five components: 1) Total water demand under socio-economic scenarios, 2) Water supply under climate change scenarios, 3) Water withdrawal for different sectors, 4) Water depletion and 5) Environmental flow. The framework, was applied to assess Urmia Lake Restoration Program (ULRP), which aims to restore the drying Urmia Lake in north-western Iran by increasing the lake inflow by 3.1×106m3yr-1. Results suggest that although the ULRP helps to increase inflow by up to 57% it is unlikely to fully reach its target. The analysis shows that there are three main reasons for the potential poor performance. The first reason is decreasing return flows due to increasing irrigation efficiency. This means that the expected increase in lake inflow volume is smaller than the volume saved by increasing irrigation efficiency. The second reason is increased depletion which is due to neglecting the fact that agricultural water demand is currently higher than available water for agriculture. As a result, increasing water use efficiency may result in increased water depletion. The third reason is ignoring the potential impact of climate change, which might decrease future water availability by 3% to 15%. Our analysis suggests that to reach the intervention target, measures need to focus on reducing Water demand and Water depletion rather than on reducing Water withdrawals. The assessment framework can be used to comprehensively assess water-saving intervention plans, particularly in water-stressed basins.

Dynamic coupling of underactuated manipulators

NASA Astrophysics Data System (ADS)

Bergerman, Marcel; Lee, Christopher; Xu, Yangsheng

1994-08-01

In recent years, researchers have been turning their attention to so called underactuated systems, where the term underactuated refers to the fact that the system has more joints than control actuators. Some examples of underactuated systems are robot manipulators with failed actuators; free-floating space robots, where the base can be considered as a virtual passive linkage in inertia space; legged robots with passive joints; hyper-redundant (snake-like) robots with passive joints, etc. From the examples above, it is possible to justify the importance of the study of underactuated systems. For example, if some actuators of a conventional manipulator fail, the loss of one or more degrees of freedom may compromise an entire operation. In free-floating space systems, the base (satellite) can be considered as a 6-DOF device without positioning actuators. Finally, manipulators with passive joints and hyper-redundant robots with few actuators are important from the viewpoint of energy saving, lightweight design and compactness.

Office-based endoscopic revision using a microdebrider for failed endoscopic dacryocystorhinostomy.

PubMed

Park, Jongyeop; Kim, Hochang

2016-12-01

This article is to introduce office-based endoscopic revision surgery using a microdebrider for failed endoscopic dacryocystorhinostomy (EN-DCR). The authors conducted retrospective, non-comparative, interventional case series analysis of 27 eyes of 24 patients, treated by office-based revision EN-DCR using a microdebrider. After local anesthesia, anatomical failures (cicatrization, granuloma, synechia) after primary EN-DCR were treated with a microdebrider (Osseoduo 120, Bien-Air Surgery, Le Noirmont, Switzerland) in an office setting, and a bicanalicular silicone tube was placed. Anatomical improvement and functional relief of epiphora were evaluated at 6-months after revision. The causes of failed EN-DCR were rhinostomy site cicatrization (17/27, 63.0 %), granulomatous obstruction (7/27, 25.9 %) and synechial formation (3/27, 11.1 %). The anatomical success rate was 100 %, and 85.2 % cases achieved complete relief of epiphora. The surgery did not exceed 10 min in any case and no complications were observed. Office-based revision EN-DCR using a microdebrider provided prompt management of post-DCR epiphora. The portable nature and all-round ability of the microdebrider allowed office-based surgery, which offered advantage to work with the surgeon's own well-trained office staff. Office-based revision EN-DCR can be both time- and money-saving, and might be regarded the treatment of choice for failed EN-DCR.

Reducing airflow energy use in multiple zone vav systems

NASA Astrophysics Data System (ADS)

Tukur, Ahmed Gidado

Variable Air Volume (VAV) systems are the most popular HVAC systems in commercial buildings. VAV systems are designed to deliver airflows at design conditions which only occur for a few hours in a year. Minimizing energy use in VAV systems requires reducing the amount of airflow delivered through the system at part load conditions. Air Handling Unit (AHU) fans are the major drivers of airflow in VAV systems and installing a Variable Frequency Drive (VFD) is the most common method of regulating airflow in VAV systems. A VFD drive does not necessarily save energy without use of an appropriate control strategy. Static pressure reset (SPR) is considered to be the most energy efficient control strategy for AHU fans with VFDs installed. The implementation of SPR however has many challenges; for example, rogue zones--zones which have faulty sensors or failed controls and actuators, system dynamics like hunting and system diversity. By investigating the parameters associated with the implementation of SPR in VAV systems, a new, improved, more stable SPR algorithm was developed and validated. This approach was further improved using Fault Detection and Diagnostics (FDD) to eliminate rogue zones. Additionally, a CO2-Demand Control Ventilation (DCV) based minimum airflow control was used to further reduce ventilation airflow and save more energy from SPR. Energy savings ranging from 25% to 51% were recorded in actual buildings with the new SPR algorithm. Finally, a methodology that utilizes historical VAV data was developed to estimate the potential savings that could be realized using SPR. The approach employed first determines an effective system loss coefficient as a function of mean damper position using the historical duct static pressure, VAV damper positions and airflows. Additionally, the historical data is used to identify the maximum mean duct damper position realizable as a result of insuring a sufficient number of VAVs are fully open at any time. Savings are estimated by shifting the damper distribution mean at each time to this maximum value and reducing the static pressure to achieve the same overall system airflow rate. The methodology was tested on three different buildings with varying system characteristics. Savings estimates correlated well to the savings actually realized from SPR. This result has significant implications for energy service providers, who could use the predictions to guarantee savings from SPR.

Hitler's penicillin.

PubMed

Wainwright, Milton

2004-01-01

During the Second World War, the Germans and their Axis partners could only produce relatively small amounts of penicillin, certainly never enough to meet their military needs; as a result, they had to rely upon the far less effective sulfonamides. One physician who put penicillin to effective use was Hitler's doctor, Theodore Morell. Morell treated the Führer with penicillin on a number of occasions, most notably following the failed assassination attempt in July 1944. Some of this penicillin appears to have been captured from, or inadvertently supplied by, the Allies, raising the intriguing possibility that Allied penicillin saved Hitler's life.

Emergency percutaneous tracheostomy in a severely burned patient with upper airway obstruction and circulatory arrest.

PubMed

Schlossmacher, Pascal; Martinet, Olivier; Testud, Richard; Agesilas, Fabrice; Benhamou, Léon; Gauzëre, Bernard Alex

2006-02-01

We report the life-saving use of Griggs percutaneous tracheostomy in an arrested patient with complex upper airway obstruction, as a result of burns, smoke injuries and iterative tracheal intubation attempts. The technique was performed blindly at bedside to treat an acute episode of failed ventilation and intubation and cardiac arrest in a patient with altered neck anatomy. The intervention salvaged the situation, leaving a definitive airway. The feasibility of using an emergency Griggs percutaneous tracheostomy versus cricothyroidotomy is suggested in selected cases.

Cost reduction with maintenance ECT in refractory bipolar disorder.

PubMed

Bonds, C; Frye, M A; Coudreaut, M F; Cunningham, M; Spearing, M; McGuire, M; Guze, B

1998-03-01

A case report of outpatient maintenance electroconvulsive therapy (ECT) is presented in a patient with bipolar disorder type I refractory to conventional medication treatment but responsive to ECT. A cost comparison is made showing substantial savings when outpatient maintenance ECT is used in lieu of inpatient hospitalization with ECT. A detailed life chart illustrating multiple medication trials that failed to stabilize the patient accompanies the financial summary. This case highlights the advantages of outpatient maintenance ECT for bipolar depression particularly with regard to safety, efficacy, and significant health care cost reduction.

Brave new world revisited revisited: Huxley's evolving view of behaviorism

PubMed Central

Newman, Bobby

1992-01-01

Aldous Huxley's Brave New World has served as a popular and powerful source of antibehavioral sentiment. Several of Huxley's works are examined in order to ascertain his true thoughts regarding behaviorism. Early in his career Huxley failed to appreciate aspects of behavioral theory (e.g., an appreciation of heredity) or the good ends to which it could be employed. Huxley's later works portrayed behaviorism in a much more positive light, and he believed that behavioral science, along with spiritual enlightenment, might help save humanity from the Brave New World he predicted. PMID:22478115

Does probability guided hysteroscopy reduce costs in women investigated for postmenopausal bleeding?

PubMed

Breijer, M C; van Hanegem, N; Visser, N C M; Verheijen, R H M; Mol, B W J; Pijnenborg, J M A; Opmeer, B C; Timmermans, A

2015-01-01

To evaluate whether a model to predict a failed endometrial biopsy in women with postmenopausal bleeding (PMB) and a thickened endometrium can reduce costs without compromising diagnostic accuracy. Model based cost-minimization analysis. A decision analytic model was designed to compare two diagnostic strategies for women with PMB: (I) attempting office endometrial biopsy and performing outpatient hysteroscopy after failed biopsy and (II) predicted probability of a failed endometrial biopsy based on patient characteristics to guide the decision for endometrial biopsy or immediate hysteroscopy. Robustness of assumptions regarding costs was evaluated in sensitivity analyses. Costs for the different strategies. At different cut-offs for the predicted probability of failure of an endometrial biopsy, strategy I was generally less expensive than strategy II. The costs for strategy I were always € 460; the costs for strategy II varied between € 457 and € 475. At a 65% cut-off, a possible saving of € 3 per woman could be achieved. Individualizing the decision to perform an endometrial biopsy or immediate hysteroscopy in women presenting with postmenopausal bleeding based on patient characteristics does not increase the efficiency of the diagnostic work-up.

A low-cost uterine balloon tamponade for management of postpartum hemorrhage: modeling the potential impact on maternal mortality and morbidity in sub-Saharan Africa.

PubMed

Herrick, Tara; Mvundura, Mercy; Burke, Thomas F; Abu-Haydar, Elizabeth

2017-11-13

Postpartum hemorrhage (PPH) is the leading cause of maternal deaths worldwide. This study sought to quantify the potential health impact (morbidity and mortality reductions) that a low-cost uterine balloon tamponade (UBT) could have on women suffering from uncontrolled PPH due to uterine atony in sub-Saharan Africa. The Maternal and Neonatal Directed Assessment of Technology (MANDATE) model was used to estimate maternal deaths, surgeries averted, and cases of severe anemia prevented through UBT use among women with PPH who receive a uterotonic drug but fail this therapy in a health facility. Estimates were generated for the year 2018. The main outcome measures were lives saved, surgeries averted, and severe anemia prevented. The base case model estimated that widespread use of a low-cost UBT in clinics and hospitals could save 6547 lives (an 11% reduction in maternal deaths), avert 10,823 surgeries, and prevent 634 severe anemia cases in sub-Saharan Africa annually. A low-cost UBT has a strong potential to save lives and reduce morbidity. It can also potentially reduce costly downstream interventions for women who give birth in a health care facility. This technology may be especially useful for meeting global targets for reducing maternal mortality as identified in Sustainable Development Goal 3.

Thermotropic nanostructured gels with complex hierarchical structure and two gelling components for water shut-off and enhance of oil recovery

NASA Astrophysics Data System (ADS)

Altunina, L. K.; Kuvshinov, I. V.; Kuvshinov, V. A.; Kozlov, V. V.; Stasyeva, L. A.

2017-12-01

This work presents the results of laboratory and field tests of thermotropic composition MEGA with two simultaneously acting gelling components, polymer and inorganic. The composition is intended for improving oil recovery and water shut-off at oilfields developed by thermal flooding, and cyclic-steam stimulated oil production wells. The composition forms an in-situ "gel-in-gel" system with improved structural-mechanical properties, using reservoir or carrier fluid heat for gelling. The gel blocks water breakthrough into producing wells and redistribute fluid flows, thus increasing the oil recovery factor.

Vapor/Mist Used to Lubricate Gears After Loss of Primary Lubrication System

NASA Technical Reports Server (NTRS)

Handschuh, Robert F.; Morales, Wilfredo

2001-01-01

Loss of lubrication in rotorcraft drive systems is a demanding requirement placed on drive system manufacturers. The drive system must operate for at least 30 minutes once the primary lubrication system has failed. This test is a military requirement that must be passed prior to certification of the aircraft. As new aircraft engines, operating at higher speeds, are fielded, the requirements for the drive system become increasingly more difficult. Also, the drive system must be lightweight, which minimizes the opportunity to use the gear bodies to absorb the tremendous amount of heating that takes place. In many cases, the amount of heat generated because of the high speed and load requires an emergency lubrication system that negatively impacts the aircraft's weight, complexity, and cost. A single mesh spur gear test rig is being used at the NASA Glenn Research Center to investigate possible emergency lubrication system improvements that will minimize the impact of having these systems onboard rotorcraft. A technique currently being investigated uses a vapor/mist system to lubricate the contacting surfaces after the primary lubrication system has been shut down. A number of tests were conducted in which the vapor/mist used the same lubricant as the primary system, but at a greatly reduced flow rate. Each test was initiated with the primary lubrication system operational and at steady-state conditions for a given speed and load. Then the primary lubrication system was shut down, and the vapor/mist lubrication system was initiated. An example of the tests conducted is shown in the figures. These preliminary tests have uncovered a mechanism that provides a lubricious, carbonaceous solid on the surface that actually reduces the surface temperature of the meshing gear teeth during operation. Surface analysis of the carbonaceous solid revealed it was graphitic. This mechanism is the synthetic lubricant "coking" on the active profile of the gears, which reduces the friction between the contacting gear surfaces. The level of load affects the onset of this mechanism: the higher the load, the sooner coking takes place. Future work will investigate several other factors that could improve the already promising results that have been attained.

An Efficient Virtual Machine Consolidation Scheme for Multimedia Cloud Computing.

PubMed

Han, Guangjie; Que, Wenhui; Jia, Gangyong; Shu, Lei

2016-02-18

Cloud computing has innovated the IT industry in recent years, as it can delivery subscription-based services to users in the pay-as-you-go model. Meanwhile, multimedia cloud computing is emerging based on cloud computing to provide a variety of media services on the Internet. However, with the growing popularity of multimedia cloud computing, its large energy consumption cannot only contribute to greenhouse gas emissions, but also result in the rising of cloud users' costs. Therefore, the multimedia cloud providers should try to minimize its energy consumption as much as possible while satisfying the consumers' resource requirements and guaranteeing quality of service (QoS). In this paper, we have proposed a remaining utilization-aware (RUA) algorithm for virtual machine (VM) placement, and a power-aware algorithm (PA) is proposed to find proper hosts to shut down for energy saving. These two algorithms have been combined and applied to cloud data centers for completing the process of VM consolidation. Simulation results have shown that there exists a trade-off between the cloud data center's energy consumption and service-level agreement (SLA) violations. Besides, the RUA algorithm is able to deal with variable workload to prevent hosts from overloading after VM placement and to reduce the SLA violations dramatically.

An Efficient Virtual Machine Consolidation Scheme for Multimedia Cloud Computing

PubMed Central

Han, Guangjie; Que, Wenhui; Jia, Gangyong; Shu, Lei

2016-01-01

Cloud computing has innovated the IT industry in recent years, as it can delivery subscription-based services to users in the pay-as-you-go model. Meanwhile, multimedia cloud computing is emerging based on cloud computing to provide a variety of media services on the Internet. However, with the growing popularity of multimedia cloud computing, its large energy consumption cannot only contribute to greenhouse gas emissions, but also result in the rising of cloud users’ costs. Therefore, the multimedia cloud providers should try to minimize its energy consumption as much as possible while satisfying the consumers’ resource requirements and guaranteeing quality of service (QoS). In this paper, we have proposed a remaining utilization-aware (RUA) algorithm for virtual machine (VM) placement, and a power-aware algorithm (PA) is proposed to find proper hosts to shut down for energy saving. These two algorithms have been combined and applied to cloud data centers for completing the process of VM consolidation. Simulation results have shown that there exists a trade-off between the cloud data center’s energy consumption and service-level agreement (SLA) violations. Besides, the RUA algorithm is able to deal with variable workload to prevent hosts from overloading after VM placement and to reduce the SLA violations dramatically. PMID:26901201

Ventilation rates in recently constructed U.S. school classrooms.

PubMed

Batterman, S; Su, F-C; Wald, A; Watkins, F; Godwin, C; Thun, G

2017-09-01

Low ventilation rates (VRs) in schools have been associated with absenteeism, poorer academic performance, and teacher dissatisfaction. We measured VRs in 37 recently constructed or renovated and mechanically ventilated U.S. schools, including LEED and EnergyStar-certified buildings, using CO 2 and the steady-state, build-up, decay, and transient mass balance methods. The transient mass balance method better matched conditions (specifically, changes in occupancy) and minimized biases seen in the other methods. During the school day, air change rates (ACRs) averaged 2.0±1.3 hour -1 , and only 22% of classrooms met recommended minimum ventilation rates. HVAC systems were shut off at the school day close, and ACRs dropped to 0.21±0.19 hour -1 . VRs did not differ by building type, although cost-cutting and comfort measures resulted in low VRs and potentially impaired IAQ. VRs were lower in schools that used unit ventilators or radiant heating, in smaller schools and in larger classrooms. The steady-state, build-up, and decay methods had significant limitations and biases, showing the need to confirm that these methods are appropriate. Findings highlight the need to increase VRs and to ensure that energy saving and comfort measures do not compromise ventilation and IAQ. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Post waterflood CO{sub 2} miscible flood in light oil fluvial: Dominated deltaic reservoirs. Third quarterly report, April 1, 1995--June 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-07-15

Production from the Marg Area 1 at Port Neches is averaging 337 BOPD for this quarter. The production drop is due to fluctuation in both GOR and BS&W on various producing wells, low water injectivity in the reservoir and shut-in one producing well to perform a workover to replace a failed gravel pack setting. Coil tubing work was performed on 2 injection wells in order to resume injection of water and CO{sub 2} in the reservoir. The Marg Area 2 did not respond favorably to CO{sub 2} injection in the Kuhn No. 6 well. For this reason Texaco will notmore » pursue any further development of this section of the reservoir due mainly to low target reserves. Instead Texaco will reallocate the money to a new Marg segment (Marg Area 3) in order to test a new process that will utilize the CO{sub 2} to accelerate the primary production rates and reduce cycle time. Also the process should reduce water disposal cost, cash lifting cost, operating cost and increase the NPV of the reserves.« less

New Life For The Cable Cars

NASA Technical Reports Server (NTRS)

1979-01-01

NASA-Arnes' major recommendations involved ways of extending cable life in the interests of safety and economy. Other recommendations included redesign of the cablegripping device, substitution of modern braking mechanisms, improvements in cable pulleys and other components, and new inspection and repair procedures. Ames followed up by designing and installing new equipment to lengthen cable life, which averages only about two months. These cables-four of them for four different car routes--are endless belts, like ski lift cables, running from the downtown car barn to the end of each line. When a cable is installed, the loop is closed by splicing the ends together in a 72-footlong splice. The splice is the weakest part of the cable and a source of problems. When the car operator applies his grip while over a splice, the resulting friction sometimes causes the splice to "unbraid" and fail; this means shutting down the line until the splice can be repaired. Even when unbraiding does not occur, gripping a splice shortens cable life by friction wear. Worn cables are a safety hazard and must be replaced, which is expensive at $1.60 a foot for 10,000 to 20,000 feet of cable.

Power Plant Replacement Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reed, Gary

2010-09-30

This report represents the final report for the Eastern Illinois University power plant replacement study. It contains all related documentation from consideration of possible solutions to the final recommended option. Included are the economic justifications associated with the chosen solution along with application for environmental permitting for the selected project for construction. This final report will summarize the results of execution of an EPC (energy performance contract) investment grade audit (IGA) which lead to an energy services agreement (ESA). The project includes scope of work to design and install energy conservation measures which are guaranteed by the contractor to bemore » self-funding over its twenty year contract duration. The cost recovery is derived from systems performance improvements leading to energy savings. The prime focus of this EPC effort is to provide a replacement solution for Eastern Illinois University’s aging and failing circa 1925 central steam production plant. Twenty-three ECMs were considered viable whose net impact will provide sufficient savings to successfully support the overall project objectives.« less

Nudging Leads Consumers In Colorado To Shop But Not Switch ACA Marketplace Plans.

PubMed

Marzilli Ericson, Keith M; Kingsdale, Jon; Layton, Tim; Sacarny, Adam

2017-02-01

The Affordable Care Act (ACA) dramatically expanded the use of regulated marketplaces in health insurance, but consumers often fail to shop for plans during open enrollment periods. Typically these consumers are automatically reenrolled in their old plans, which potentially exposes them to unexpected increases in their insurance premiums and cost sharing. We conducted a randomized intervention to encourage enrollees in an ACA Marketplace to shop for plans. We tested the effect of letters and e-mails with personalized information about the savings on insurance premiums that they could realize from switching plans and the effect of generic communications that simply emphasized the possibility of saving. The personalized and generic messages both increased shopping on the Marketplace's website by 23 percent, but neither type of message had a significant effect on plan switching. These findings show that simple "nudges" with even generic information can promote shopping in health insurance marketplaces, but whether they can lead to switching remains an open question. Project HOPE—The People-to-People Health Foundation, Inc.

Long-Term Cost-Effectiveness of Transanal Irrigation in Patients with Neurogenic Bowel Dysfunction.

PubMed

Emmanuel, Anton; Kumar, Gayathri; Christensen, Peter; Mealing, Stuart; Størling, Zenia M; Andersen, Frederikke; Kirshblum, Steven

2016-01-01

People suffering from neurogenic bowel dysfunction (NBD) and an ineffective bowel regimen often suffer from fecal incontinence (FI) and related symptoms, which have a huge impact on their quality of life. In these situations, transanal irrigation (TAI) has been shown to reduce these symptoms and improve quality of life. To investigate the long-term cost-effectiveness of initiating TAI in patients with NBD who have failed standard bowel care (SBC). A deterministic Markov decision model was developed to project the lifetime health economic outcomes, including quality-adjusted life years (QALYs), episodes of FI, urinary tract infections (UTIs), and stoma surgery when initiating TAI relative to continuing SBC. A data set consisting of 227 patients with NBD due to spinal cord injury (SCI), multiple sclerosis, spina bifida and cauda equina syndrome was used in the analysis. In the model a 30-year old individual with SCI was used as a base-case. A probabilistic sensitivity analysis was applied to evaluate the robustness of the model. The model predicts that a 30-year old SCI patient with a life expectancy of 37 years initiating TAI will experience a 36% reduction in FI episodes, a 29% reduction in UTIs, a 35% reduction in likelihood of stoma surgery and a 0.4 improvement in QALYs, compared with patients continuing SBC. A lifetime cost-saving of £21,768 per patient was estimated for TAI versus continuing SBC alone. TAI is a cost-saving treatment strategy reducing risk of stoma surgery, UTIs, episodes of FI and improving QALYs for NBD patients who have failed SBC.

Role of the NSs protein in the zoonotic capacity of Orthobunyaviruses.

PubMed

Hart, T J; Kohl, A; Elliott, R M

2009-08-01

The family Bunyaviridae contains over 350 named isolates, classified into five genera: Orthobunyavirus, Hantavirus, Nairovirus, Phlebovirus and Tospovirus. The Orthobunyavirus genus contains some 170 isolates that are mainly transmitted by mosquitoes and are responsible for a range of disease syndromes in humans including self-limiting febrile illness, encephalitis and haemorrhagic fever. The viruses have a tripartite, negative-sense RNA genome. Analyses of viruses in four serogroups (Bunyamwera, California, Group C and Simbu) showed that the smallest (S) RNA segment encodes the nucleocapsid protein (N) and a non-structural protein called (NSs). The NSs protein of Bunyamwera virus (BUNV) has been shown to play a role in shut-off of host cell protein synthesis in mammalian cells, but no protein shut-off is observed in BUNVinfected mosquito cells (Aedes albopictus C6/36 cells). Protein shut-off in infected mammalian cells is achieved by global inhibition of RNA polymerase II-mediated transcription and enables the virus to overcome the host innate immune response. As innate defence mechanisms constitute a significant barrier to virus infection of different hosts, NSs would appear to play a key role in determining the zoonotic capacity of orthobunyaviruses.

Degradation Study by Start-Up/Shut-Down Cycling of Superhydrophobic Electrosprayed Catalyst Layers Using a Localized Reference Electrode Technique.

PubMed

Ferreira-Aparicio, Paloma; Chaparro, Antonio M; Folgado, M Antonia; Conde, Julio J; Brightman, Edward; Hinds, Gareth

2017-03-29

Degradation of a polymer electrolyte membrane fuel cell (PEMFC) with electrosprayed cathode catalyst layers is investigated during cyclic start-up and shut-down events. The study is carried out within a single cell incorporating an array of reference electrodes that enables measurement of cell current as a function of local cathode potential (localized polarization curves). Accelerated degradation of the cell by start-up/shut-down cycling gives rise to inhomogeneous performance loss, which is more severe close to the gas outlet and occurs predominantly during start-up. The degradation consists primarily of loss of cathode catalyst activity and increase in cell internal resistance, which is attributed to carbon corrosion and Pt aggregation in both anode and cathode. Cells with an electrosprayed cathode catalyst layer show lower degradation rates during the first 100 cycles, compared with those of a conventional gas diffusion electrode. This difference in behavior is attributed to the high hydrophobicity of the electrosprayed catalyst layer microstructure, which retards the kinetics of corrosion of the carbon support. In the long term, however, the degradation rate is dominated by the Pt/C ratio in the cathode catalyst layer.

Evapotranspiration management based on the application of SWAT for balancing water consumption: A case study in Guantao, China

NASA Astrophysics Data System (ADS)

Liu, Bin; Gan, Hong

2018-06-01

Rapid social and economic development results in increased demand for water resources. This can lead to the unsustainable development and exploitation of water resources which in turn causes significant environmental problems. Conventional water resource management approaches, such as supply and demand management strategies, frequently fail to restore regional water balance. This paper introduces the concept of water consumption balance, the balance between actual evapotranspiration (ET) and target ET, and establishes a framework to realize regional water balance. The framework consists of three stages: (1) determination of target ET and actual ET; (2) quantification of the water-saving requirements for the region; and (3) reduction of actual ET by implementing various water saving management strategies. Using this framework, a case study was conducted for Guantao County, China. The SWAT model was utilized to aid in the selection of the best water saving management strategy by comparing the ET of different irrigation methods and crop pattern adjustments. Simulation results revealed that determination of SWAT model parameters using remote sensing ET is feasible and that the model is a valuable tool for ET management. Irrigation was found to have a greater influence on the ET of winter wheat as compared to that of maize, indicating that reduction in winter wheat cultivation is the most effective way to reduce regional ET. However, the effect of water-saving irrigation methods on the reduction of ET was not obvious. This indicates that it would be difficult to achieve regional ET reduction using water-saving irrigation methods only. Furthermore, selecting the best water saving management strategy by relying solely on the amount of reduced ET was insufficient, because it ignored the impact of water conservation measures on the livelihood of the agricultural community. Incorporating these considerations with our findings, we recommend changing the current irrigation method to sprinkler irrigation and replacing 20% of the winter wheat-maize cultivated area with cotton, as the best strategy to achieve water balance in the study area.

Bridging knee arthrodesis for limb salvage using an intramedullary cemented nail: a retrospective outcome analysis of a case series.

PubMed

Neuerburg, Carl; Bieger, Ralf; Jung, Sebastian; Kappe, Thomas; Reichel, Heiko; Decking, Ralf

2012-08-01

Failed total knee replacement with compromised bone and soft-tissues can be challenging. In these situations, arthrodesis remains a treatment option of a limb-saving procedure. We investigated the outcome of treatment with an intramedullary cemented knee arthrodesis nail implanted in 22 consecutive patients with forlorn situations after failed total knee replacement. There were three major complications due to re-infection and two minor complications due to wound-healing disturbances that healed with the implant retained after an average follow-up of 3.4 years. Clinical examination, Short Form-36 and Oxford knee scores revealed low pain levels, safe implant anchorage, and improved stability of the knee, whilst autonomous mobility utilizing walking aids was still possible. Bridging knee arthrodesis with an intramedullary nail is a valuable salvage procedure with acceptable clinical results. As recurring infection remains the most challenging complication, regular clinical and radiological follow-up examinations are necessary following implant-related knee arthrodesis to allow timely intervention in case of loosening.

Psychological aspects of retirement: About Schmidt (2002), and Everybody's Fine (2009).

PubMed

Wolman, Thomas

2011-06-01

With the films About Schmidt and Everybody's Fine as his main point of reference, the author elucidates the complex and often melancholic sojourn that follows ordinary men's retirement from their jobs. As this usually occurs during late middle age, the complicating variable of spousal loss, departure of children from the family home, a failing body, and social marginalization also get added to the picture. The vicissitudes of the resulting intrapsychic and interpersonal upheaval can lead to depressive withdrawal or a renewed effort at finding meaning in life. Ego resilience is tested and sublimation and creativity, if possible, save the day.

When all else fails: 21st century Amateur Radio as an emergency communications medium.

PubMed

Nollet, Kenneth E; Ohto, Hitoshi

2013-12-01

Twenty-first century demand for radio spectrum continues to increase with the explosive growth of wireless devices, but authorities reserve slices of the spectrum for licensed Amateur Radio operators, recognizing their value to the public, particularly with respect to providing emergency communications. Blood banking and transfusion medicine are among the specialties that should also recognize the value of Amateur Radio as an emergency communications medium, because blood collection, testing, processing, storage, and transfusion are life-saving activities that in modern times can be separated by considerable distance. Copyright © 2013 Elsevier Ltd. All rights reserved.

Must doctors save their patients?

PubMed

Harris, J

1983-12-01

Do doctors and other medical staff have an obligation to treat those who need their help? This paper assumes no legal or contractual obligations but attempts to discover whether there is any general moral obligation to treat those in need. In particular the questions of whether or not the obligation that falls on medical staff is different from that of others and of whether doctors are more blameworthy than others if they fail to treat patients are examined. Finally we look at the question of the burden of this obligation and at the responsibility of society to mitigate its hardships.

Must doctors save their patients?

PubMed Central

Harris, J

1983-01-01

Do doctors and other medical staff have an obligation to treat those who need their help? This paper assumes no legal or contractual obligations but attempts to discover whether there is any general moral obligation to treat those in need. In particular the questions of whether or not the obligation that falls on medical staff is different from that of others and of whether doctors are more blameworthy than others if they fail to treat patients are examined. Finally we look at the question of the burden of this obligation and at the responsibility of society to mitigate its hardships. PMID:6668586

Application of lasers in endodontics

NASA Astrophysics Data System (ADS)

Ertl, Thomas P.; Benthin, Hartmut; Majaron, Boris; Mueller, Gerhard J.

1997-12-01

Root canal treatment is still a problem in dentistry. Very often the conventional treatment fails and several treatment sessions are necessary to save the tooth from root resection or extraction. Application of lasers may help in this situation. Bacteria reduction has been demonstrated both in vitro and clinically and is either based on laser induced thermal effects or by using an ultraviolet light source. Root canal cleansing is possible by Er:YAG/YSGG-Lasers, using the hydrodynamic motion of a fluid filled in the canals. However root canal shaping using lasers is still a problem. Via falsas and fiber breakage are points of research.

Exploring K-12 mathematics course progression: implications for collegiate success in Florida

NASA Astrophysics Data System (ADS)

Campbell, Bethany; Varney, Christopher; Wade, Aaron

Increasingly, Florida college students are pressured to change their major as few times as possible and take only required classes, all in order to ``Finish in Four, Save More''. If they fail to do so, they may be subject to penalties such as Excess Hour Fees. Partially as a result of this, students wishing to study STEM are at a significant disadvantage if they enter college unprepared to take calculus their first semester. We explore the various ``paths to success'' to STEM degrees, defined by entering college having taken calculus in high school, starting from fifth grade onwards.

Interactive program for analysis and design problems in advanced composites technology

NASA Technical Reports Server (NTRS)

Cruse, T. A.; Swedlow, J. L.

1971-01-01

During the past year an experimental program in the fracture of advanced fiber composites has been completed. The experimental program has given direction to additional experimental and theoretical work. A synthesis program for designing low weight multifastener joints in composites is proposed, based on extensive analytical background. A number of failed joints have been thoroughly analyzed to evaluate the failure hypothesis used in the synthesis procedure. Finally, a new solution is reported for isotropic and anisotropic laminates using the boundary-integral method. The solution method offers significant savings of computer core and time for important problems.

What if Things Get Worse? Really Grand Challenges for Modeling and Simulation in a Risky and Complex World or Modeling and Simulation for the "Greater Good"?

NASA Technical Reports Server (NTRS)

Fifrey, Priscilla

2010-01-01

Today Modeling and Simulation-- ---as an important practice or industry or area of expertise ----- is at a complex crossroad - a sort of cyber-highway--where these complexities meet-technical, economic, environmental, geopolitical and cultural. They may converge or collide. Let's not kid ourselves. It is all too much for anyone person or organization Malcolm Gladwell said it. "We have constructed a world in which the potential for high tech catastrophe is embedded in the fabric of everyday life." We are surrounded by problems that scream at us from our television, Internet and social networks along with billboards and protest signs. We face not just high tech catastrophes but, also, landslides, earthquakes, tornados, floods and hurricanes and large-scale criminality. Evil, war, famine and pestilence have not gone away. It is all too much to think about. My friend, George Peabody, who taught me everything I know about power said that addressing such issues requires that we constantly build our network, information resources and the credibility and visibility of our work. That is how we will build the power of simulation so it can change the world --even maybe, save it. We need all the help we can get and give one another because our human early warning systems appear to be out of kilter. We seem to have trouble imagining how small failings can continue to lead to catastrophic disaster. Think about O-rings and blowout preventers. One is reminded of the old nursery rhyme, "For want of a nail, a shoe was lost! for want of a shoe the horse was lost! for want of a rider the battle was lost and so the kingdom fell." Although the investigation will take more time for real answers, it is worrisome that a rig worker reported to the BBC that-- weeks before the explosion of Deep Ocean Horizon. -he identified a leak in the oil rig's safety equipment -the Control Pod of the blowout preventer which has giant shears designed to cut and seal off the well's main pipe. With both electronics and hydraulics, these are effectively the brains of the blowout preventer. No one fixed it, he alleges, they just shut it down and relied on the other control pod -an act deemed unacceptable by petroleum expert, Tad Patzek, at the University of Texas. The US Congress has identified numerous other problems with the blowout preventer, including design problems and unexpected modifications.

Energy Efficiency Potential in the U.S. Single-Family Housing Stock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, Eric J.; Christensen, Craig B.; Horowitz, Scott G.

Typical approaches for assessing energy efficiency potential in buildings use a limited number of prototypes, and therefore suffer from inadequate resolution when pass-fail cost-effectiveness tests are applied, which can significantly underestimate or overestimate the economic potential of energy efficiency technologies. This analysis applies a new approach to large-scale residential energy analysis, combining the use of large public and private data sources, statistical sampling, detailed building simulations, and high-performance computing to achieve unprecedented granularity - and therefore accuracy - in modeling the diversity of the single-family housing stock. The result is a comprehensive set of maps, tables, and figures showing themore » technical and economic potential of 50 plus residential energy efficiency upgrades and packages for each state. Policymakers, program designers, and manufacturers can use these results to identify upgrades with the highest potential for cost-effective savings in a particular state or region, as well as help identify customer segments for targeted marketing and deployment. The primary finding of this analysis is that there is significant technical and economic potential to save electricity and on-site fuel use in the single-family housing stock. However, the economic potential is very sensitive to the cost-effectiveness criteria used for analysis. Additionally, the savings of particular energy efficiency upgrades is situation-specific within the housing stock (depending on climate, building vintage, heating fuel type, building physical characteristics, etc.).« less

Percutaneous coronary intervention with oral sirolimus and bare metal stents has comparable safety and efficacy to treatment with drug eluting stents, but with significant cost saving: long-term follow-up results from the randomised, controlled ORAR III (Oral Rapamycin in ARgentina) study.

PubMed

Rodriguez, Alfredo E; Maree, Andrew; Tarragona, Sonia; Fernandez-Pereira, Carlos; Santaera, Omar; Rodriguez Granillo, Alfredo M; Rodriguez-Granillo, Gaston A; Russo-Felssen, Miguel; Kukreja, Neville; Antoniucci, David; Palacios, Igor F; Serruys, Patrick W

2009-06-01

Previous randomised studies have shown a significant reduction in restenosis when oral rapamycin (OR) is administered to patients undergoing bare metal stent (BMS) implantation. How this regimen compares to drug eluting stents (DES) is unknown. Two-hundred patients with de novo coronary lesions were randomised to treatment with OR plus BMS (100 pts) or with DES (100 pts). OR was given as a bolus of 10 mg per day before PCI followed by daily doses of 3 mg during following 13 days. Primary endpoints were to compare hospital, follow-up and overall cost at one, two, three and five years of follow-up. The secondary endpoints included death, myocardial infarction (MI) and stroke and were analysed as major adverse cardiovascular events (MACCE). Target vessel (TVR) and target lesion revascularisation (TLR) were independently analysed. Costs included procedural resources, hospitalisation, medications, repeat revascularisation procedures and professional fees. Baseline demographic, clinical and angiographic characteristics were similar. At 18.3 +/- 7 months of follow-up, the initial strategy of OR plus BMS resulted in significant cost saving when compared to DES (p=0.0001). TLR rate was 8.2% with DES and 7.0% with OR plus BMS (p=0.84), similarly no differences in TVR rate in both groups was seen (10.6% and 10.5% in OR and DES group respectively, p=0.86). Non-inferiority testing, determined that DES therapy failed to be cost saving compared to OR in all possible cost scenarios. A strategy of OR plus BMS is cost saving compared to DES in patients undergoing PCI for de novo coronary lesions.

CONTROL RODS FOR NUCLEAR REACTORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bell, F.R.

1963-01-16

A means for controlling the control rod in emergency, when it is desired to shutdown the reactor with the shortest possible delay, is described. When the emergency occurs the control rod is allowed to drop freely under gravity from the control rod support tube into the bore in the reactor core. A normal shutdown is reached almost at the lowest rod position. In the shut-down position and also below it, the control rod had its full effect of reducing the level of activity in the core. When the shut-down position was reached, a brake came into action to decelerate themore » rod and reduce shock and the likelihood of damage. (C.E.S.)« less

Evaluation of the long-term cost-effectiveness of IDegLira versus liraglutide added to basal insulin for patients with type 2 diabetes failing to achieve glycemic control on basal insulin in the USA.

PubMed

Hunt, B; Mocarski, M; Valentine, W J; Langer, J

2017-07-01

IDegLira, a fixed ratio combination of insulin degludec and glucagon-like peptide-1 receptor agonist liraglutide, utilizes the complementary mechanisms of action of these two agents to improve glycemic control with low risk of hypoglycemia and avoidance of weight gain. The aim of the present analysis was to assess the long-term cost-effectiveness of IDegLira vs liraglutide added to basal insulin, for patients with type 2 diabetes not achieving glycemic control on basal insulin in the US setting. Projections of lifetime costs and clinical outcomes were made using the IMS CORE Diabetes Model. Treatment effect data for patients receiving IDegLira and liraglutide added to basal insulin were modeled based on the outcomes of a published indirect comparison, as no head-to-head clinical trial data is currently available. Costs were accounted in 2015 US dollars ($) from a healthcare payer perspective. IDegLira was associated with small improvements in quality-adjusted life expectancy compared with liraglutide added to basal insulin (8.94 vs 8.91 discounted quality-adjusted life years [QALYs]). The key driver of improved clinical outcomes was the greater reduction in glycated hemoglobin associated with IDegLira. IDegLira was associated with mean costs savings of $17,687 over patient lifetimes vs liraglutide added to basal insulin, resulting from lower treatment costs and cost savings as a result of complications avoided. The present long-term modeling analysis found that IDegLira was dominant vs liraglutide added to basal insulin for patients with type 2 diabetes failing to achieve glycemic control on basal insulin in the US, improving clinical outcomes and reducing direct costs.

Terrestrial Applications of Zero Boil-Off Cryogen Storage

NASA Technical Reports Server (NTRS)

Salerno, L. J.; Gaby, J.; Hastings, L.; Johnson, R.; Kittel, P.; Marquardt, E.; Plachta, D.; Arnold, James O. (Technical Monitor)

2000-01-01

Storing cryogenic propellants with zero boil off (ZBO) using a combination of active (cryocoolers) and passive technologies has recently received a great deal of attention for applications such as future long-term space missions. This paper will examine a variety of potential near-term terrestrial applications for ZBO and, where appropriate, provide a rough order of magnitude cost benefit of implementing ZBO technology. NASA's Space Shuttle power system uses supercritical propellant tanks, which are filled several days before launch. If the launch does not occur within 48-96 hours, the tanks must be drained and refilled, further delaying the launch. By implementing ZBO, boil off could be eliminated and pad hold time extended. At the launch site, vented liquid hydrogen (LH2) storage dewars lose 1200-1600 gal/day through boiloff. Implementing ZBO would eliminate this, saving $300,000-$400,000 per year. Similarly, overland trucking of LH2 from the supplier to the launch site via roadable dewars results in a cryogen loss of ten percent per tanker (1500 gal/tanker). Providing a cryocooler on board the rig would prevent this loss. Previous work investigating variable density insulation found that a 50% reduction in evaporation from a 6000 gallon dewar would save $5000 per year. For a 20 year dewar lifetime, the payback period would be less than two years. Similar benefits could be realized at other storage facilities across the nation. Within the superconductivity community, there is skepticism about using coolers, based upon reliability concerns. By providing a cooler on the dewar, lifetime could be extended while retaining fail-safe capability. If the cooler failed, it would merely lower the storage life of the dewar.

Fluid dynamics following flow shut-off in bottle filling

NASA Astrophysics Data System (ADS)

Thete, Sumeet; Appathurai, Santosh; Gao, Haijing; Basaran, Osman

2012-11-01

Bottle filling is ubiquitous in industry. Examples include filling of bottles with shampoos and cleaners, engine oil and pharmaceuticals. In these examples, fluid flows out of a nozzle to fill bottles in an assembly line. Once the required volume of fluid has flowed out of the nozzle, the flow is shut off. However, an evolving fluid thread or string may remain suspended from the nozzle following flow shut-off and persist. This stringing phenomenon can be detrimental to a bottle filling operation because it can adversely affect line speed and filling accuracy by causing uncertainty in fill volume, product loss and undesirable marring of the bottles' exterior surfaces. The dynamics of stringing are studied numerically primarily by using the 1D, slender-jet approximation of the flow equations. A novel feature entails development and use of a new boundary condition downstream of the nozzle exit to expedite the computations. While the emphasis is on stringing of Newtonian fluids and use of 1D approximations, results will also be presented for situations where (a) the fluids are non-Newtonian and (b) the full set of equations are solved without invoking the 1D approximation. Phase diagrams will be presented that identify conditions for which stringing can be problematic.

Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection.

PubMed

Sukarieh, R; Sonenberg, N; Pelletier, J

2010-05-01

Eukaryotic initiation factor (eIF) 4E is a subunit of the cap-binding protein complex, eIF4F, which recognizes the cap structure of cellular mRNAs to facilitate translation initiation. eIF4E is assembled into the eIF4F complex via its interaction with eIF4G, an event that is under Akt/mTOR regulation. The eIF4E-eIF4G interaction is regulated by the eIF4E binding partners, eIF4E-binding proteins and eIF4E-transporter. Cleavage of eIF4G occurs upon poliovirus infection and is responsible for the shut-off of host-cell protein synthesis observed early in infection. Here, we document that relocalization of eIF4E to the nucleus occurs concomitantly with cleavage of eIF4G upon poliovirus infection. This event is not dependent upon virus replication, but is dependent on eIF4G cleavage. We postulate that eIF4E nuclear relocalization may contribute to the shut-off of host protein synthesis that is a hallmark of poliovirus infection by perturbing the circular status of actively translating mRNAs.

General process improvements through pinch technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linnhoff, B.; Polley, G.T.; Sahdev, V.

1988-06-01

Over the last ten years pinch technology has emerged as somewhat of a ''maverick'' development in the process design and energy conservation scene. Running contrary to general trends by taking the computer out of the loop and putting the engineer back in control, it has been questioned by some and welcomed by others. Regardless of persuasion, however, critics and advocates alike have largely failed to notice that pinch technology is more than an energy conservation tool. This is probably because soon after the advent of pinch technology in the 1970s, the process design scene became dominated by the oil crisis.more » Energy savings became the primary task of process designers and, therefore, the primary focus of the technology. Application during this period typically demonstrated energy cost savings in the range of 20 to 50 percent and payback periods of one year or less. Only recently have the other benefits of the technology reemerged. While it is true that pinch technology is essentially a heat-flow-based technique it is also true that it can be used to address a very diverse range of objectives.« less

Activation of single heteromeric GABAA receptor ion channels by full and partial agonists

PubMed Central

Mortensen, Martin; Kristiansen, Uffe; Ebert, Bjarke; Frølund, Bente; Krogsgaard-Larsen, Povl; Smart, Trevor G

2004-01-01

The linkage between agonist binding and the activation of a GABAA receptor ion channel is yet to be resolved. This aspect was examined on human recombinant α1β2γ2S GABAA receptors expressed in human embryonic kidney cells using the following series of receptor agonists: GABA, isoguvacine, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP), isonipecotic acid, piperidine-4-sulphonic acid (P4S), imidazole-4-acetic acid (IAA), 5-(4-piperidyl)-3-isothiazolol (thio-4-PIOL) and 5-(4-piperidyl)-3-isoxazolol (4-PIOL). Whole-cell concentration–response curves enabled the agonists to be categorized into four classes based upon their maximum responses. Single channel analyses revealed that the channel conductance of 25–27 pS was unaffected by the agonists. However, two open states were resolved from the open period distributions with mean open times reduced 5-fold by the weakest partial agonists. Using saturating agonist concentrations, estimates of the channel shutting rate, α, ranged from 200 to 600 s−1. The shut period distributions were described by three or four components and for the weakest partial agonists, the interburst shut periods increased whilst the mean burst durations and longest burst lengths were reduced relative to the full agonists. From the burst analyses, the opening rates for channel activation, β, and the total dissociation rates, k−1, for the agonists leaving the receptor were estimated. The agonist efficacies were larger for the full agonists (E ∼7−9) compared to the weak partial agonists (∼0.4–0.6). Overall, changes in agonist efficacy largely determined the different agonist profiles with contributions from the agonist affinities and the degree of receptor desensitization. From this we conclude that GABAA receptor activation does not occur in a switch-like manner since the agonist recognition sites are flexible, accommodating diverse agonist structures which differentially influence the opening and shutting rates of the ion channel. PMID:14990676

The role of the donor liaison officer at PlusLife (Perth Bone and Tissue Bank Inc.), Western Australia.

PubMed

Smythe, Claire; White, Nicola; Winter, Joyleen; Cowie, Anne

2015-06-01

Femoral head donation at the time of hip replacement surgery provides a much needed resource of bone allograft to orthopaedic surgeons. Prior to 2005, potential femoral head donors were identified and consented in the hospital setting on the day of surgery. This resulted in over 40 % of donations failing post operatively suggesting that more effort could be given to pre-operative screening resulting in substantial savings in the cost associated with collection and testing of donors who were subsequently failed. The Donor Liaison role was implemented in 2005 to coordinate a Femoral Head Donation program maximising the number of successful donations through pre-operative screening. This study reviews the effectiveness of pre-operative screening of potential femoral head donors at PlusLife from 2002-2012. A retrospective audit of the database was undertaken 2002-2012 and medical/social reasons for pre-operative and postoperative failures were collated into 4 main categories to enable comparison: malignancy, autoimmune conditions, variant Creutzfeldt Jakob disease risk and general medical/social reasons. The number of femoral heads failed post operatively has decreased significantly from 26 % in 2003 to 6 % in 2012. A cost of $121,000 was expended on femoral heads failed post operatively in 2004, as compared to $20,350 in 2012. Donors excluded due to the 4 main categories (medical/social history) were identified pre-operatively in over 80 % of all cases. Preoperative screening of femoral head donors through a coordinated Femoral Head Donation Program is a safe and cost effective method.

Regulation of Staphylococcal Penicillinase Synthesis

PubMed Central

Imsande, John; Zyskind, Judith W.; Mile, Imre

1972-01-01

5-Methyl tryptophan was found to be an efficient inducer of penicillinase synthesis in Staphylococcus aureus. Addition of actinomycin D or tryptophan to the culture medium shuts off the 5-methyl tryptophan-induced synthesis of penicillinase with an apparent half-life of approximately 1 to 2 min, respectively. Hence, in the induction of penicillinase synthesis, 5-methyl tryptophan seems to function as a structural analogue of penicillin rather than by becoming incorporated in proteins and thereby creating faulty penicillinase repressor or antirepressor. This conclusion is supported by similarities in the structures of the two compounds as revealed by solid atomic models. The fact that S. aureus exposed to 14C-penicillin in the absence of protein synthesis failed to synthesize penicillinase at an increased level when cell growth was resumed strongly suggests that a protein involved in the regulation of penicillinase synthesis must be synthesized in the presence of the penicillinase inducer. In turn, this observation suggests that the penicillinase inducer promotes penicillinase synthesis by directing the penicillinase regulatory protein (i.e., the penicillinase antirepressor) to acquire a different conformation when it is synthesized in the presence of the penicillinase inducer. A working model for the regulation of penicillinase synthesis based on these and other data has been constructed and is presented. Images PMID:4333374

Science in Flux: NASA's Nuclear Program at Plum Brook Station 1955-2005

NASA Technical Reports Server (NTRS)

Bowles, Mark D.

2006-01-01

Science in Flux traces the history of one of the most powerful nuclear test reactors in the United States and the only nuclear facility ever built by NASA. In the late 1950's NASA constructed Plum Brook Station on a vast tract of undeveloped land near Sandusky, Ohio. Once fully operational in 1963, it supported basic research for NASA's nuclear rocket program (NERVA). Plum Brook represents a significant, if largely forgotten, story of nuclear research, political change, and the professional culture of the scientists and engineers who devoted their lives to construct and operate the facility. In 1973, after only a decade of research, the government shut Plum Brook down before many of its experiments could be completed. Even the valiant attempt to redefine the reactor as an environmental analysis tool failed, and the facility went silent. The reactors lay in costly, but quiet standby for nearly a quarter-century before the Nuclear Regulatory Commission decided to decommission the reactors and clean up the site. The history of Plum Brook reveals the perils and potentials of that nuclear technology. As NASA, Congress, and space enthusiasts all begin looking once again at the nuclear option for sending humans to Mars, the echoes of Plum Brook's past will resonate with current policy and space initiatives.

RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis.

PubMed

Li, Changhong; Zhao, Jinxia; Sun, Lin; Yao, Zhongqiang; Liu, Rui; Huang, Jiansheng; Liu, Xiangyuan

2012-12-14

The receptor activator of nuclear factor-κB ligand (RANKL), as a member of the tumor necrosis factor (TNF) family, plays an essential role in osteoclast differentiation and function. Chemokines and their receptors have recently been shown to play critical roles in osteoclastogenesis, however, whether CXCL16-CXCR6 plays role in RANKL-mediated osteoclastogenesis is unknown. In this study, we first reported that RANKL decreased CXCR6 in a dose-dependent manner, which may be through deactivation of Akt and STAT3 signaling induced by CXCL16. Interestingly, RANKL-mediated CXCR6 reduction may be associated to the activation of STAT3 by phosphorylation. When STAT3 activation was blocked by JAK2/STAT3 inhibitor AG490, RANKL failed to shut down CXCR6 expression during osteoclastogenesis. However, CXCL16 alone did not augment RANKL-mediated osteoclast differentiation and did not alter RANKL-receptor RANK mRNA expression. These results demonstrate that reduction of CXCL16-CXCR6 is critical in RANKL-mediated osteoclastogenesis, which is mainly through the activation of JAK2/STAT3 signaling. CXCL16-CXCR6 axis may become a novel target for the therapeutic intervention of bone resorbing diseases such as rheumatoid arthritis and osteoporosis. Copyright © 2012 Elsevier Inc. All rights reserved.

Closeout of IE Bulletin 83-05: ASME nuclear code pumps and spare parts manufactured by the Hayward Tyler Pump Company

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foley, W.J.; Dean, R.S.; Hennick, A.

Documentation is provided in this report to close IE Bulletin 83-05 regarding ASME nuclear code pumps and spare parts manufactured by the Hayward Tyler Pump Company (HTPC). The bulletin was issued (1) to alert holders of operating licenses and construction permits of nuclear power plants that HTPC failed to implement effectively their quality assurance (QA) program from 1977 to 1981 and (2) to require affected utilities to take action to resolve the potential for failure of the subject pumps and their spare parts. Evaluation of utility responses and NRC/Region inspection reports shows that reliability of the affected pumps was ensuredmore » by means of procedures and performance testing of the pumps as required by the bulletin. Based on the evaluation, in accordance with specific criteria, the bulletin is closed for 116 (98%) of the 118 facilities to which it was issued for action and which were not shut down indefinitely or permanently at the time of issuance of this report. A follow-up item is proposed for the two facilities with open bulletin status. Based on favorable results, a conclusion is presented to indicate that the bulletin concerns have been resolved.« less

Etude experimentale et optimisation d'un systeme hybride hydraulique pour camions a ordures et amelioration des performances par raffinement de sa logique de controle

NASA Astrophysics Data System (ADS)

Lacroix, Benoit

The aim of this thesis is to demonstrate experimentally the operation of a hydraulic hybrid system specifically dedicated to the application of refuse trucks in addition to proposing solutions to improve its control strategy. The developed hybrid system recovers the vehicle's kinetic energy during braking. A variable displacement hydraulic motor then uses the energy stored in a hydraulic accumulator to assist the internal combustion engine (ICE) at suitable times. The particular aspect of this system is that assistance to the ICE can occur when it operates at idle and drives the auxiliary hydraulic equipment of the refuse truck. Essentially, the control strategy initially developed maximizes the recovery of braking energy and uses that energy to minimize the solicitation of the ICE at idle. The experimental results obtained with two prototypes tested in real operating conditions show that the hybrid system can recover a significant portion of braking energy. In addition, the results show that it is possible to reduce the load on the ICE during idle with the application of an assisting torque. However, the advantage of assisting the ICE in specific areas of the operating range is slim since the ICE's gross efficiency varies only slightly depending on conditions of operation. This is confirmed by the optimization of the control logic using deterministic dynamic programming. Indeed, by managing the pressure in the accumulator to maximize the amount of energy recovered during braking and by dosing the assistance to the ICE in an ideal fashion, the optimal control only managed to improve fuel savings by 6% in comparison to the original control. Therefore, since the efforts that would be required to emulate the ideal behavior in real time are significant for a relatively small and uncertain gain, the initial control logic is considered near optimal. Finally, this thesis proposes an improved version of the torque assisting hybrid system that could shut down the ICE when the vehicle is stopped while maintaining functional the auxiliary hydraulic equipment. An optimization of the control logic indicates that proper management of the pressure in the accumulator would allow turning off the ICE most of the time at stop and thus, would increase the fuel savings by over 40% compared to the original system. The simulation of a basic control strategy shows that such pressure management may be feasible in real time and that the potential gain in fuel savings is achievable. Keywords: hybrid system, hydraulic, control, refuse truck.

Formation and removal of PCDD/Fs in a municipal waste incinerator during different operating periods.

PubMed

Wang, Hou Chuan; Hwang, Jyh Feng; Chi, Kai Hsien; Chang, Moo Been

2007-04-01

The PCDD/F concentrations and removal efficiencies achieved with air pollution control devices (APCDs) during different operating periods (start-up, normal operation, and shut-down) at an existing municipal waste incinerator (MWI) in Taiwan are evaluated via stack sampling and analysis. The MWI investigated is equipped with electrostatic precipitators (EP), wet scrubbers (WS), and selective catalytic reduction system (SCR) as APCDs. The sampling results indicate that the PCDD/F concentrations at the EP inlet during start-up period were 15 times higher than that measured during normal operation period. The PCDD/F concentration observed at shut-down period was close to that measured at normal operation period. The CO concentration was between 400 and 1000 ppm during start-up period, which was about 50 times higher compared with the normal operation. Hence, combustion condition significantly affected the PCDD/F formation concentration during the waste incineration process. In addition, the distributions of the PCDD/F congeners were similar at different operating periods. During the normal operation and shut-down periods, the EP decreases the PCDD/F concentration (based on TEQ) by 18.4-48.6%, while the removal efficiency of PCDD/Fs achieved with SCR system reaches 99.3-99.6%. Nevertheless, the PCDD/F removal efficiency achieved with SCR was only 42% during the 19-h start-up period due to the low SCR operating temperature (195 degrees C).

Decommissioning of the High Flux Beam Reactor at Brookhaven National Laboratory.

PubMed

Hu, Jih-Perng; Reciniello, Richard N; Holden, Norman E

2012-08-01

The High Flux Beam Reactor (HFBR) at the Brookhaven National Laboratory was a heavy-water cooled and moderated reactor that achieved criticality on 31 October 1965. It operated at a power level of 40 mega-watts. An equipment upgrade in 1982 allowed operations at 60 mega-watts. After a 1989 reactor shutdown to reanalyze safety impact of a hypothetical loss of coolant accident, the reactor was restarted in 1991 at 30 mega-watts. The HFBR was shut down in December 1996 for routine maintenance and refueling. At that time, a leak of tritiated water was identified by routine sampling of ground water from wells located adjacent to the reactor's spent fuel pool. The reactor remained shut down for almost 3 y for safety and environmental reviews. In November 1999, the United States Department of Energy decided to permanently shut down the HFBR. The decontamination and decommissioning of the HFBR complex, consisting of multiple structures and systems to operate and maintain the reactor, were complete in 2009 after removing and shipping off all the control rod blades. The emptied and cleaned HFBR dome, which still contains the irradiated reactor vessel is presently under 24/7 surveillance for safety. Details of the HFBR's cleanup performed during 1999-2009, to allow the BNL facilities to be re-accessed by the public, will be described in the paper.

Formative assessment of GP trainees' clinical skills.

PubMed

Wiener-Ogilvie, Sharon; Begg, Drummond

2012-03-01

Clinical skill assessment (CSA) has been an integral part of the Royal College of General Practitioners' membership examination (MRCGP) since 2008. It is an expensive, high-stakes examination with first time pass rates ranging from 76.4 to 81.3. In this paper we describe the South East Scotland Deanery, NHS Education Scotland, pilot of a formative clinical skills assessment (fCSA) using the principles of formative assessment and OSCE. The purpose of the study was to assess the acceptability of the fCSA and to examine whether trainees, identified during the fCSA as 'at risk of failing the MRCGP CSA exam', are more likely to fail the MRCGP CSA exam later on in the year. Trainees were assessed in four clinical skills stations under exam conditions. After each station they were given verbal feedback and subsequently both trainee and their trainer received written feedback. We assessed the value of the exercise through written feedback from trainees and trainers. Each trainee's performance in fCSA was triangulated with trainer assessment to identify 'flagged trainees'. We compared flagged and non-flagged trainees' performance in MRCGP CSA. Both trainees and trainers highly rated the fCSA. Overall 97% of non-flagged trainees have passed the RCGP CSA exam by May of that year in comparison to 80% of flagged trainees who have passed the RCGP CSA (P = 0.005). Trainers and trainees rated the fCSA as excellent and useful. We were able to demonstrate that the fCSA can be used to identify those trainees likely to fail the RCGP CSA. Contrary to reservations about the potential to demoralise trainees, the fCSA was viewed as a useful and a positive experience by both trainees and trainers. In addition, we suggest that feedback from fCSA was useful in triggering appropriate educational interventions. Early intervention with trainees who are predicted to fail the CSA has the potential to reduce deaneries overall fail rate. Preventing one trainee failure could save over £30 000.

Livestock Anaerobic Digester Database

EPA Pesticide Factsheets

The Anaerobic Digester Database provides basic information about anaerobic digesters on livestock farms in the United States, organized in Excel spreadsheets. It includes projects that are under construction, operating, or shut down.

15 CFR 716.9 - Report of inspection-related costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS... records, and costs associated with shutting down chemical production or processing during inspections, if...

15 CFR 717.4 - Report of inspection-related costs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS...), costs of producing records, and costs associated with shutting down chemical production or processing...

15 CFR 716.9 - Report of inspection-related costs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS... records, and costs associated with shutting down chemical production or processing during inspections, if...

Transplantectomy is associated with presensitization with donor-reactive T cells and graft failure after kidney retransplantation: a cohort study.

PubMed

Schachtner, Thomas; Otto, Natalie M; Stein, Maik; Reinke, Petra

2018-05-01

The number of kidney transplant recipients (KTRs) being waitlisted for a subsequent transplantation has disproportionately increased to almost 25%. Evidence for the optimal management of the failed allograft, however, remains inconsistent. We studied 111 KTRs who underwent their second kidney transplantation from 1998 to 2015. In 51/111 KTRs (46%) the failed allograft was removed and in 60/111 (54%) the failed allograft was retained. KTRs with primary non-function and allograft loss <12  months of the first failed allograft were excluded from analysis. Samples were collected before transplantation and at  1  month posttransplantation and donor-reactive T cells were measured using an interferon-γ enzyme-linked immunosorbent spot assay. KTRs with the previous allograft removed showed significantly higher rates of acute cellular rejection compared with KTRs with the previous allograft retained [27/51 KTRs (53%) versus 18/60 KTRs (30%); P = 0.019]. KTRs with the previous allograft removed showed significantly inferior death-censored allograft survival compared with KTRs with the previous allograft retained (P = 0.022). Here, KTRs with the previous allograft removed showed significantly higher donor-reactive T cells pretransplantation compared with KTRs with the previous allograft retained (P = 0.012). Interestingly, no differences were observed for the presence of panel reactive antibodies and for the development of de novo donor-specific antibodies. Our data suggest higher cellular presensitization among KTRs with the previous allograft removed, which is associated with higher rates of acute cellular rejection and inferior allograft survival. Immunological mechanisms that may account for these differences may include prolonged maintenance immunosuppression to save urine output in KTRs with the first kidney allograft retained and cellular presensitization after withdrawal of maintenance immunosuppression, which lead to allograft rejection and ultimately to allograft nephrectomy.

Preoperative Anemia Is Associated With Failure of Open Debridement Polyethylene Exchange in Acute and Acute Hematogenous Prosthetic Joint Infection.

PubMed

Swenson, Richard D; Butterfield, James A; Irwin, Timothy J; Zurlo, John J; Davis, Charles M

2018-06-01

Acute and acute hematogenous prosthetic joint infections (PJIs) are often treated with open debridement and polyethylene exchange (ODPE) in an effort to save the prosthesis, decrease morbidity, and reduce costs. However, failure of ODPE may compromise a subsequent 2-stage treatment. The purpose of this study is to identify patient factors that impact the success of ODPE for acute and acute hematogenous PJIs. A retrospective review examined comorbidities, preoperative laboratory values, and patient history for patients with successful and failed ODPE treatment for acute perioperative or acute hematogenous periprosthetic hip or knee joint infections. Successful treatment was defined as retaining a well-fixed implant without the need for additional surgery for a minimum of 6-month follow-up with or without lifelong oral maintenance antibiotics. Fifty-three of 72 patients (73.6%) underwent successful ODPE. Of the 19 failures, 14 completed 2-stage revision with one subsequent known failure for recurrent infection. Patients with a Staphylococcus aureus infection were more likely to fail ODPE (48.3% vs 11.6%, P = .0012, odds ratio 7.1, 95% confidence interval 2.3-25.3). Patients with a preoperative hematocrit ≤32.1 were also more likely to fail ODPE (55% vs 16%, P = .0013, odds ratio 6.7, 95% confidence interval 2.2-22.4). When neither risk factor was present, 97.1% of PJIs were successfully treated with ODPE. S aureus infection and preoperative hematocrit ≤32.1 are independent risk factors for ODPE failure. ODPE is a safe alternative to 2-stage revision in patients without preoperative anemia and without S aureus infection. Two-thirds of patients with a failed ODPE were successfully treated with a 2-stage reimplantation. Copyright © 2018 Elsevier Inc. All rights reserved.

About Arrhythmia

MedlinePlus

... may shut down or be damaged. View an animation of arrhythmia . Types of Arrhythmias Atrial Fibrillation = upper ... learn about: S tructure of the heart Watch an animation of heart valve anatomy The heart: four chambers, ...

43 CFR 3162.3-2 - Subsequent well operations.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., perform nonroutine fracturing jobs, recomplete in a different interval, perform water shut off... practice, prior approval is not required for routine fracturing or acidizing jobs, or recompletion in the...

Sterilization by Laparoscopy

MedlinePlus

... shut with bands or clips, sealed with an electric current, or blocked with scar tissue formed by ... closed with special thread or sealed with an electric current. The laparoscope then is withdrawn. The incisions ...

Isoetharine Oral Inhalation

MedlinePlus

... emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier ... through your nose while keeping your mouth shut. Open Mouth Technique: Open your mouth wide, and place ...

Behavioral economics: merging psychology and economics for lifestyle interventions.

PubMed

Thorgeirsson, Tryggvi; Kawachi, Ichiro

2013-02-01

The field of behavioral economics combines psychology and economics to investigate how individuals actually behave as opposed to how they would behave if they were being perfectly rational (as in the sense of maximizing their utility). Although initial applications focused on consumer behavior, such as explaining why people failed to save adequately for retirement, the field has moved increasingly into the area of explaining health behaviors as well as the design of lifestyle interventions, such as weight loss and smoking-cessation programs. This article provides an overview of several important behavioral economics concepts of relevance to public health and health behavior change. Copyright © 2013 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

F-15 HiDEC taxi on ramp at sunrise

NASA Image and Video Library

1991-09-23

NASA's highly modified F-15A (Serial #71-0287) used for digital electronic flight and engine control systems research, at sunrise on the ramp at the Dryden Flight Research Facility, Edwards, California. The F-15 was called the HIDEC (Highly Integrated Digital Electronic Control) flight facility. Research programs flown on the testbed vehicle have demonstrated improved rates of climb, fuel savings, and engine thrust by optimizing systems performance. The aircraft also tested and evaluated a computerized self-repairing flight control system for the Air Force that detects damaged or failed flight control surfaces. The system then reconfigures undamaged control surfaces so the mission can continue or the aircraft is landed safely.

[Early transjugular intrahepatic portosystemic shunt: When, how and in whom?].

PubMed

Ruiz-Blard, Esteban; Baiges, Anna; Turon, Fanny; Hernández-Gea, Virginia; García-Pagán, Juan Carlos

2016-01-01

Early TIPS is basically a new application of an old concept. This intervention used to be a useful rescue therapy when other interventions failed but has now become a primary intervention in patients with variceal bleeding and risk factors for poor prognosis. This technique has also been proven to control bleeding and has a definite survival advantage at 6 weeks and 1 year over standard therapy with vasoactive drugs and endoscopy, without increasing the rate of adverse events. In well-trained hands and with appropriate candidate selection, early TIPS is a safe, life-saving and evidenced-based procedure. Copyright © 2015 Elsevier España, S.L.U. y AEEH y AEG. All rights reserved.

Liver transplantation for severe hepatic trauma: Experience from a single center

PubMed Central

Delis, Spiros G; Bakoyiannis, Andreas; Selvaggi, Gennaro; Weppler, Debbie; Levi, David; Tzakis, Andreas G

2009-01-01

Liver transplantation has been reported in the literature as an extreme intervention in cases of severe and complicated hepatic trauma. The main indications for liver transplant in such cases were uncontrollable bleeding and postoperative hepatic insufficiency. We here describe four cases of orthotopic liver transplantation after penetrating or blunt liver trauma. The indications were liver failure, extended liver necrosis, liver gangrene and multiple episodes of gastrointestinal bleeding related to portal hypertension, respectively. One patient died due to postoperative cerebral edema. The other three patients recovered well and remain on immunosuppression. Liver transplantation should be considered as a saving procedure in severe hepatic trauma, when all other treatment modalities fail. PMID:19340909

Potential for Integrating Entry Guidance into the Multi-Disciplinary Entry Vehicle Optimization Environment

NASA Technical Reports Server (NTRS)

D'souza, Sarah N.; Kinney, David J.; Garcia, Joseph A.; Sarigul-Klijn, Nesrin

2014-01-01

The state-of-the-art in vehicle design decouples flight feasible trajectory generation from the optimization process of an entry spacecraft shape. The disadvantage to this decoupled process is seen when a particular aeroshell does not meet in-flight requirements when integrated into Guidance, Navigation, and Control simulations. It is postulated that the integration of a guidance algorithm into the design process will provide a real-time, rapid trajectory generation technique to enhance the robustness of vehicle design solutions. The potential benefit of this integration is a reduction in design cycles (possible cost savings) and increased accuracy in the aerothermal environment (possible mass savings). This work examines two aspects: 1) the performance of a reference tracking guidance algorithm for five different geometries with the same reference trajectory and 2) the potential of mass savings from improved aerothermal predictions. An Apollo Derived Guidance (ADG) algorithm is used in this study. The baseline geometry and five test case geometries were flown using the same baseline trajectory. The guided trajectory results are compared to separate trajectories determined in a vehicle optimization study conducted for NASA's Mars Entry, Descent, and Landing System Analysis. This study revealed several aspects regarding the potential gains and required developments for integrating a guidance algorithm into the vehicle optimization environment. First, the generation of flight feasible trajectories is only as good as the robustness of the guidance algorithm. The set of dispersed geometries modelled aerodynamic dispersions that ranged from +/-1% to +/-17% and a single extreme case was modelled where the aerodynamics were approximately 80% less than the baseline geometry. The ADG, as expected, was able to guide the vehicle into the aeroshell separation box at the target location for dispersions up to 17%, but failed for the 80% dispersion cases. Finally, the results revealed that including flight feasible trajectories for a set of dispersed geometries has the potential to save mass up to 430 kg.

Cyanoacrylates

MedlinePlus

Wash exposed areas with warm water right away. If the glue gets on the eyelids, try to keep the eyelids separated. If the eye becomes glued shut, get emergency medical care right away. If the eye is partially ...

Subway platform air quality: Assessing the influences of tunnel ventilation, train piston effect and station design

NASA Astrophysics Data System (ADS)

Moreno, T.; Pérez, N.; Reche, C.; Martins, V.; de Miguel, E.; Capdevila, M.; Centelles, S.; Minguillón, M. C.; Amato, F.; Alastuey, A.; Querol, X.; Gibbons, W.

2014-08-01

A high resolution air quality monitoring campaign (PM, CO2 and CO) was conducted on differently designed station platforms in the Barcelona subway system under: (a) normal forced tunnel ventilation, and (b) with daytime tunnel ventilation systems shut down. PM concentrations are highly variable (6-128 μgPM1 m-3, 16-314 μgPM3 m-3, and 33-332 μgPM10 m-3, 15-min averages) depending on ventilation conditions and station design. Narrow platforms served by single-track tunnels are heavily dependent on forced tunnel ventilation and cannot rely on the train piston effect alone to reduce platform PM concentrations. In contrast PM levels in stations with spacious double-track tunnels are not greatly affected when tunnel ventilation is switched off, offering the possibility of significant energy savings without damaging air quality. Sampling at different positions along the platform reveals considerable lateral variation, with the greatest accumulation of particulates occurring at one end of the platform. Passenger accesses can dilute PM concentrations by introducing cleaner outside air, although lateral down-platform accesses are less effective than those positioned at the train entry point. CO concentrations on the platform are very low (≤1 ppm) and probably controlled by ingress of traffic-contaminated street-level air. CO2 averages range from 371 to 569 ppm, changing during the build-up and exchange of passengers with each passing train.

"A normality for us without confinement for them": notes on the associations of families of the mentally ill.

PubMed

Giannichedda, M G

1989-01-01

Associations of families of the mentally ill arose in Italy in the early 1980s mainly in the country's northern and central regions. They denounced the inadequacies of an extramural service conceived of as an out-patient clinic filling the void left by the shutting down of asylums. The positions elaborated by these associations focus on four main themes: the distribution of the "burden of care" for the ill between services and families; the ill-conceived interpretation of the families' needs owing to the professional's alleged tendency to "point the finger of guilt" at the families themselves; the demand for greater power in regard to decisions made by the services; the interaction with the rights and liberties of the mentally ill. Two different ranges of problems are discussed. First, there is the conflict within the family between the interests and rights of its income-producing and its "dependent" members. This conflict points not to a loss but to an overload of functions shifted to the family at a time of rising expectations for the satisfaction of needs. It therefore calls for services of a new kind, i.e. services capable of making these conflicting interests and rights compatible. Second, extramural services either reject or misinterpret the asylum's labour-saving function. These services thus ascribe care for the material life of the mentally ill to the family's own resources alone.(ABSTRACT TRUNCATED AT 250 WORDS)

14 CFR 171.315 - Azimuth monitor system requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... an error in the time division multiplex synchronization of a particular azimuth function that the...). If the fault is not cleared within the time allowed, the ground equipment must be shut down. After...

14 CFR 171.315 - Azimuth monitor system requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... an error in the time division multiplex synchronization of a particular azimuth function that the...). If the fault is not cleared within the time allowed, the ground equipment must be shut down. After...

14 CFR 171.315 - Azimuth monitor system requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... an error in the time division multiplex synchronization of a particular azimuth function that the...). If the fault is not cleared within the time allowed, the ground equipment must be shut down. After...

30 CFR 75.1403-4 - Criteria-Automatic elevators.

Code of Federal Regulations, 2010 CFR

2010-07-01

... appropriate on automatic elevators which will automatically shut-off the power and apply the brakes in the... telephone or other effective communication system by which aid or assistance can be obtained promptly. ...

29 CFR 1918.53 - Cargo winches.

Code of Federal Regulations, 2010 CFR

2010-07-01

... control levers operate with excessive friction or excessive play. (c) Double gear winches or other winches... left unattended, control levers shall be placed in the neutral position and the power shall be shut off...

12. Historic American Buildings Survey R. Randolph Langenbach, Photographer August, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey R. Randolph Langenbach, Photographer August, 1967 INTERIOR, BASEMENT, BUTTERFLY SHUT-OFF GATE AND MECHANISM, SOUTH PENSTOCK - Lawrence Machine Shop, Union & Canal Streets, Lawrence, Essex County, MA

Automatic shutoff valve

NASA Technical Reports Server (NTRS)

Hawkins, S. F.; Overbey, C. W.

1980-01-01

Cellulose-sponge disk absorbs incoming water and expands with enough force to shut valve. When water recedes, valve opens by squeezing sponge dry to its original size. This direct mechanical action is considered more reliable than solenoid valve.

40 CFR 62.5127 - Identification of plan-Negative Declaration

Code of Federal Regulations, 2010 CFR

2010-07-01

... Maryland Emissions from Existing Commercial and Industrial Solid Waste Incinerator (ciswi) Units-Negative... permanently shut down and have been dismantled in the state. [70 FR 53569, Sept. 9, 2005] Landfill Gas...

A community screening program for Helicobacter pylori saves money: 10-year follow-up of a randomized controlled trial.

PubMed

Ford, Alexander C; Forman, David; Bailey, Alastair G; Axon, Anthony T R; Moayyedi, Paul

2005-12-01

Population screening and treatment of Helicobacter pylori has been advocated as a means of reducing mortality from gastric cancer, as well as dyspepsia and dyspepsia-related resource use. Previous programs have failed to demonstrate a significant effect on mortality or resource use, but follow-up was only for 1 or 2 years. We aimed to determine the effect of screening for H pylori on dyspepsia and dyspepsia-related resource use over 10 years. H pylori-positive individuals, aged 40-49 years, enrolled in a community screening program, randomized to eradication therapy or placebo in 1994, were sent a validated dyspepsia questionnaire by mail 10 years later, and primary care records were reexamined. Consultation, referral, prescribing, and investigation data related to dyspepsia were extracted. United Kingdom costs were applied to derive total cost per person (1 pound = 1.8 dollars). Of 2324 original participants, 1864 (80%) were traced and contacted. Of these, 1086 (47%) responded, and 919 (40%) agreed to a review of their primary care records. There was a 10-year mean saving in total dyspepsia-related costs of 117 dollars per person (95% confidence interval [CI] = 11 dollars-220 dollars, P = .03) with eradication therapy. Those symptomatic at baseline showed a nonsignificant trend toward resolution of symptoms at 10 years with eradication therapy (relative risk of remaining symptomatic, 0.89; 95% CI: 0.77-1.03). There were significant reductions in total dyspepsia-related health care costs. The savings made were greater than the initial cost of H pylori screening and treatment.

Taming a wild geothermal research well in yellowstone national park

USGS Publications Warehouse

Fournier, Robert O.; Pisto, Larry M.; Howell, Bruce B.; Hutchnson, Roderick A.; ,

1993-01-01

In November 1992 the valve at the top of a U.S. Geological Survey drill hole in Yellowstone National Park parted from the casting as a result of corrosion. This allowed uncontrolled venting of boiling water and steam from the well at an estimated liquid flow rate of about 25-50 gallons per minute. A flow diverter assembly was designed, fabricated and installed on the well within 16 days, which allowed drill rods to be safely stripped into the well through on annular Blow-Out Preventer. Once this was accomplished it was a relatively routine matter to set a packer in the casting and cement the well shut permanently. The drill hole was brought under control and cemented shut within 18 days of the wellhead failure at a total cost of $47,066, which was about $5,000 less than anticipated.

Design a 10 kJ IS Mather Type Plasma Focus for Solid Target Activation to Produce Short-Lived Radioisotopes 12C(d,n)13N

NASA Astrophysics Data System (ADS)

Sadat Kiai, S. M.; Adlparvar, S.; Sheibani, S.; Elahi, M.; Safarien, A.; Farhangi, S.; Zirak, A. R.; Alhooie, S.; Mortazavi, B. N.; Khalaj, M. M.; Khanchi, A. R.; Dabirzadeh, A. A.; Kashani, A.; Zahedi, F.

2010-10-01

A 10 kJ (15 kV, 88 μF) IS (Iranian Sun) Mather type plasma focus device has been studied to determine the activity of a compound exogenous carbon solid target through 12C(d,n)13N nuclear reaction. The produced 13N is a short-lived radioisotope with a half-life of 9.97 min and threshold energy of 0.28 MeV. The results indicate that energetic deuterons impinging on the solid target can produce yield of = 6.7 × 10-5 with an activity of A = 6.8 × 104 Bq for one plasma focus shut and A ν = 4 × 105 Bq for 6 shut per mint when the projectile maximum deuterons energy is E max = 3 MeV.

18. VIEW SOUTHWEST OF 450 HP TURBINE INSTALLATION IN BASEMENT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. VIEW SOUTHWEST OF 450 HP TURBINE INSTALLATION IN BASEMENT OF GRANITEVILLE MILL. MAIN FEATURE OF THE PHOTOGRAPH IS THE PENSTOCK CONDUCTING WATER TO THE TURBINE IN THE BACKGROUND. THE PENSTOCK IS OF RIVETED IRON CONSTRUCTION AND REPLACED A WOOD PENSTOCK IN 1882. THE COVERED OPENING IN THE CENTER OF THE PHOTOGRAPH ORIGINALLY CONNECTED TO A STANDPIPE WHICH EXITED VERTICALLY THROUGH THE MILL. THE STANDPIPE MODERATED WATER PRESSURE AND SERVED AS A SAFETY FEATURE IN THE EVENT THE TURBINE GATES WERE RAPIDLY CLOSED. (IF LOAD IN THE MILL WERE SUDDENLY STOPPED-SAY AT QUITTING TIME-THE GATES WOULD SHUT DOWN FLOW TO THE TURBINE. THE STANDPIPE OFFERED A PLACE FOR THE WATER, RAPIDLY MOVING THROUGH THE PENSTOCK, TO ESCAPE. IN A SHUT-DOWN SITUATION WATER WOULD ... - Graniteville Mill, Marshall Street, Graniteville, Aiken County, SC

Lagrangian formulation for penny-shaped and Perkins-Kern geometry models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, W.S.

1989-09-01

This paper discusses basic theories for vertical penny-shaped and Perkins-Kern (PK) geometry models developed with a Lagrangian formulation combined with a virtual-work analysis. The Lagrangian formulation yields a pair of nonlinear equations in R/sub f/ or L/sub f/ and b/sub f/, the fracture radius or length and half-width. By introduction of a virtual-work analysis, a simple equation is obtained that can be solved numerically. This equation is written in a form that can be used to determine fracture geometry when the fluid-loss coefficient of the fracturing fluid is known. Also, this equation, coupled with a material-balance equation after shut-in, canmore » be used to analyze pressure-decline data after shut-in to determine the effective fluid-loss coefficient and fracture geometry.« less

Solid Lubricants for Oil-Free Turbomachinery

NASA Technical Reports Server (NTRS)

DellaCorte, Christopher

2005-01-01

Recent breakthroughs in gas foil bearing solid lubricants and computer based modeling has enabled the development of revolulionary Oil-Free turbomachinery systems. These innovative new and solid lubricants at low speeds (start-up and shut down). Foil bearings are hydrodynamic, self acting fluid film bearings made from thin, flexible sheet metal foils. These thin foils trap a hydrodynamic lubricating air film between their surfaces and moving shaft surface. For low temperature applications, like ainrafl air cycle machines (ACM's), polymer coatings provide important solid lubrication during start-up and shut down prior to the development of the lubricating fluid film. The successful development of Oil-Free gas turbine engines requires bearings which can operate at much higher temperatures (greater than 300 C). To address this extreme solid lubrication need, NASA has invented a new family of compostie solid lubricant coatings, NASA PS300.

Repairing pipes on the fly

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-04-01

When piping develops leaks, the natural instinct is to shut the process down, purge the lines and call in maintenance crews to make the repairs. There is, however, an alternative: on-the-fly repairs. Through the use of specialized tools, equipment and technicians, shut-off valves can be installed and leaks repaired without interrupting production. The split sleeve offers one of the simpler approaches to on-the-fly repairs. Two half cylinders with inside diameter slightly larger than the outside diameter slightly larger than the outside diameter of the pipe to be repaired are slipped over the latter some distance form the leak and looselymore » bolted together. The cylinder is then slid over the leaking area and the bolts tightened. Gaskets inside the half cylinders provide the needed seal between the pipe and the cylinder. Installing a shut-off valve in an operating pipeline requires much more specialized equipment and skills than does repairing a leak with a split sleeve. A device available from International Piping Services Co. allows a trained crew to isolate a section of pipe, drill out the isolated portion, install a blocking valve and then remove the isolation system--all while continuing to operate the pipeline at temperatures to 700 F and pressures to 700 psi. But Herb Porter, CEO of Ipsco, cautions that unlike the repairing leaks with a split sleeve, installing a blocking valve on-the-fly always demands the services of a highly trained crew.« less

Efforts to control radiation build-up in Ringhals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Egner, K.; Aronsson, P.O.; Erixon, O.

1995-03-01

It is well known that good control of the primary chemistry in a PWR is essential in order to minimize material problems and fuel damages. It has also been well established that the water chemistry has a great influence on accumulation of corrosion products on the fuel and the radiation build-up on primary system surfaces. Ringhals was one of the pioneers to increase operating pH in order to reduce radiation build-up and has now been operating for ten years with pH at 7.4 or (in later years) 7.2. Our experience is favourable and includes low radiation levels in the newmore » (1989) steam generators of Ringhals 2. Ringhals 4 has operated almost its whole life at pH 7.2 or higher and it remains one of the cleanest PWRs of its vintage. In addition to strict adherence to a stable operating chemistry, Ringhals is now working on a program with the aim to find optimum shut-down and start-up chemistry to reduce activity levels in the primary systems. A particular goal is to use the shut-down and start-up chemistry at the 1994 outage in Ringhals 3 in order to reduce doserates in preparation for the planned steam generator replacement in 1995. The paper summarizes the experience to date of the established operating chemistry, on-going tests with modified shut-down and start-up chemistry and other measures to limit or reduce the activity build-up.« less

On the physics-based processes behind production-induced seismicity in natural gas fields

NASA Astrophysics Data System (ADS)

Zbinden, Dominik; Rinaldi, Antonio Pio; Urpi, Luca; Wiemer, Stefan

2017-05-01

Induced seismicity due to natural gas production is observed at different sites worldwide. Common understanding states that the pressure drop caused by gas production leads to compaction, which affects the stress field in the reservoir and the surrounding rock formations and hence reactivates preexisting faults and induces earthquakes. In this study, we show that the multiphase fluid flow involved in natural gas extraction activities should be included. We use a fully coupled fluid flow and geomechanics simulator, which accounts for stress-dependent permeability and linear poroelasticity, to better determine the conditions leading to fault reactivation. In our model setup, gas is produced from a porous reservoir, divided into two compartments that are offset by a normal fault. Results show that fluid flow plays a major role in pore pressure and stress evolution within the fault. Fault strength is significantly reduced due to fluid flow into the fault zone from the neighboring reservoir compartment and other formations. We also analyze scenarios for minimizing seismicity after a period of production, such as (i) well shut-in and (ii) gas reinjection. In the case of well shut-in, a highly stressed fault zone can still be reactivated several decades after production has ceased, although on average the shut-in results in a reduction in seismicity. In the case of gas reinjection, fault reactivation can be avoided if gas is injected directly into the compartment under depletion. However, gas reinjection into a neighboring compartment does not stop the fault from being reactivated.

When Doing Wrong Feels So Right: Normalization of Deviance.

PubMed

Price, Mary R; Williams, Teresa C

2018-03-01

Normalization of deviance is a term first coined by sociologist Diane Vaughan when reviewing the Challenger disaster. Vaughan noted that the root cause of the Challenger disaster was related to the repeated choice of NASA officials to fly the space shuttle despite a dangerous design flaw with the O-rings. Vaughan describes this phenomenon as occurring when people within an organization become so insensitive to deviant practice that it no longer feels wrong. Insensitivity occurs insidiously and sometimes over years because disaster does not happen until other critical factors line up. In clinical practice, failing to do time outs before procedures, shutting off alarms, and breaches of infection control are deviances from evidence-based practice. As in other industries, health care workers do not make these choices intending to set into motion a cascade toward disaster and harm. Deviation occurs because of barriers to using the correct process or drivers such as time, cost, and peer pressure. As in other industries, operators will often adamantly defend their actions as necessary and justified. Although many other high-risk industries have embraced the normalization of deviance concept, it is relatively new to health care. It is urgent that we explore the impact of this concept on patient harm. We can borrow this concept from other industries and also the steps these other high-risk organizations have found to prevent it.

41 CFR 102-36.40 - What definitions apply to this part?

Code of Federal Regulations, 2012 CFR

2012-01-01

..., malfunction, or absence could cause a catastrophic failure resulting in engine shut-down or loss or serious... contemplated activity. GSAXcess ® is GSA's website for reporting, searching and selecting excess personal...

41 CFR 102-36.40 - What definitions apply to this part?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., malfunction, or absence could cause a catastrophic failure resulting in engine shut-down or loss or serious... contemplated activity. GSAXcess ® is GSA's website for reporting, searching and selecting excess personal...

41 CFR 102-36.40 - What definitions apply to this part?

Code of Federal Regulations, 2014 CFR

2014-01-01

..., malfunction, or absence could cause a catastrophic failure resulting in engine shut-down or loss or serious... contemplated activity. GSAXcess ® is GSA's website for reporting, searching and selecting excess personal...

29 CFR 1910.333 - Selection and use of work practices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... continuous industrial process in a chemical plant that would otherwise need to be completely shut down in... chains, necklaces, metalized aprons, cloth with conductive thread, or metal headgear) may not be worn if...

29 CFR 1910.333 - Selection and use of work practices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... continuous industrial process in a chemical plant that would otherwise need to be completely shut down in... chains, necklaces, metalized aprons, cloth with conductive thread, or metal headgear) may not be worn if...

29 CFR 1910.333 - Selection and use of work practices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... continuous industrial process in a chemical plant that would otherwise need to be completely shut down in... chains, necklaces, metalized aprons, cloth with conductive thread, or metal headgear) may not be worn if...

29 CFR 1910.333 - Selection and use of work practices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... continuous industrial process in a chemical plant that would otherwise need to be completely shut down in... chains, necklaces, metalized aprons, cloth with conductive thread, or metal headgear) may not be worn if...

29 CFR 1910.333 - Selection and use of work practices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... continuous industrial process in a chemical plant that would otherwise need to be completely shut down in... chains, necklaces, metalized aprons, cloth with conductive thread, or metal headgear) may not be worn if...

30. STARBOARD REFUELING STATION STARBOARD LOOKING TO PORT SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. STARBOARD REFUELING STATION - STARBOARD LOOKING TO PORT SHOWING RIGGING, FUEL RISER, SHUT-OFF VALVE, TEST COCK AND PRESSURE GAUGE. - U.S.S. HORNET, Puget Sound Naval Shipyard, Sinclair Inlet, Bremerton, Kitsap County, WA

40 CFR 87.11 - Standard for fuel venting emissions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... venting emissions shall be discharged into the atmosphere from any new or in-use aircraft gas turbine... the atmosphere of fuel drained from fuel nozzle manifolds after engines are shut down and does not...

A shut-off valve for flexible tubing

NASA Technical Reports Server (NTRS)

Reyburn, W. W.

1972-01-01

Design of light weight valve for flexible tubing is described. Valve is hand operated and provides positive sealing in normally closed position. Diagram is provided to show construction of valve. Principles of operation are explained.

46 CFR 76.33-15 - Piping.

Code of Federal Regulations, 2013 CFR

2013-10-01

... system serves a space used alternately for liquid and dry cargo, a valve shall be installed between the tank and the detecting cabinet so that the line may be shut off when liquids are carried. When the...

46 CFR 76.33-15 - Piping.

Code of Federal Regulations, 2012 CFR

2012-10-01

... system serves a space used alternately for liquid and dry cargo, a valve shall be installed between the tank and the detecting cabinet so that the line may be shut off when liquids are carried. When the...

46 CFR 76.33-15 - Piping.

Code of Federal Regulations, 2011 CFR

2011-10-01

... system serves a space used alternately for liquid and dry cargo, a valve shall be installed between the tank and the detecting cabinet so that the line may be shut off when liquids are carried. When the...

46 CFR 76.33-15 - Piping.

Code of Federal Regulations, 2010 CFR

2010-10-01

... system serves a space used alternately for liquid and dry cargo, a valve shall be installed between the tank and the detecting cabinet so that the line may be shut off when liquids are carried. When the...

46 CFR 76.33-15 - Piping.

Code of Federal Regulations, 2014 CFR

2014-10-01

... system serves a space used alternately for liquid and dry cargo, a valve shall be installed between the tank and the detecting cabinet so that the line may be shut off when liquids are carried. When the...

29 CFR 1910.430 - Equipment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... a ventilated area and protected from excessive heat; (3) Be secured from falling; and (4) Have shut... pull force of the line over the diver's body. [39 FR 23502, June 27, 1974, as amended at 49 FR 18295...

29 CFR 1910.430 - Equipment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... a ventilated area and protected from excessive heat; (3) Be secured from falling; and (4) Have shut... pull force of the line over the diver's body. [39 FR 23502, June 27, 1974, as amended at 49 FR 18295...

29 CFR 1910.430 - Equipment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... a ventilated area and protected from excessive heat; (3) Be secured from falling; and (4) Have shut... pull force of the line over the diver's body. [39 FR 23502, June 27, 1974, as amended at 49 FR 18295...

29 CFR 1910.430 - Equipment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... a ventilated area and protected from excessive heat; (3) Be secured from falling; and (4) Have shut... pull force of the line over the diver's body. [39 FR 23502, June 27, 1974, as amended at 49 FR 18295...

Stress Management

MedlinePlus

Healthy Lifestyle Stress management By Mayo Clinic Staff Stress basics Stress is a normal psychological and physical reaction to the demands of life. ... some people's alarm systems rarely shut off. Stress management gives you a range of tools to reset ...

49 CFR 192.171 - Compressor stations: Additional safety equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... operates with pressure gas injection must be equipped so that stoppage of the engine automatically shuts off the fuel and vents the engine distribution manifold. (e) Each muffler for a gas engine in a...

49 CFR 192.171 - Compressor stations: Additional safety equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... operates with pressure gas injection must be equipped so that stoppage of the engine automatically shuts off the fuel and vents the engine distribution manifold. (e) Each muffler for a gas engine in a...

41 CFR 102-36.40 - What definitions apply to this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., malfunction, or absence could cause a catastrophic failure resulting in engine shut-down or loss or serious... contemplated activity. GSAXcess ® is GSA's website for reporting, searching and selecting excess personal...

41 CFR 102-36.40 - What definitions apply to this part?

Code of Federal Regulations, 2011 CFR

2011-01-01

..., malfunction, or absence could cause a catastrophic failure resulting in engine shut-down or loss or serious... contemplated activity. GSAXcess ® is GSA's website for reporting, searching and selecting excess personal...

Competitive bidding for health insurance contracts: lessons from the online HMO auctions.

PubMed

Gupta, Alok; Parente, Stephen T; Sanyal, Pallab

2012-12-01

Healthcare is an important social and economic component of modern society, and the effective use of information technology in this industry is critical to its success. As health insurance premiums continue to rise, competitive bidding may be useful in generating stronger price competition and lower premium costs for employers and possibly, government agencies. In this paper, we assess an endeavor by several Fortune 500 companies to reduce healthcare procurement costs for their employees by having HMOs compete in open electronic auctions. Although the auctions were successful in generating significant cost savings for the companies in the first year, i.e., 1999, they failed to replicate the success and were eventually discontinued after two more years. Over the past decade since the failed auction experiment, effective utilization of information technologies have led to significant advances in the design of complex electronic markets. Using this knowledge, and data from the auctions, we point out several shortcomings of the auction design that, we believe, led to the discontinuation of the market after three years. Based on our analysis, we propose several actionable recommendations that policy makers can use to design a sustainable electronic market for procuring health insurance.

Micro-fragmented adipose tissue injection for the treatment of complex anal fistula: a pilot study accessing safety and feasibility.

PubMed

Naldini, G; Sturiale, A; Fabiani, B; Giani, I; Menconi, C

2018-02-01

The aim of the present study was to evaluate the safety and efficacy of autologous, micro-fragmented and minimally manipulated adipose tissue injection associated closure of the internal opening in promoting healing of complex anal fistula. A pilot study was conducted on patients referred to our center with anal fistula, from April 2015-December 2016. Inclusion criteria were age over 16 years old and a diagnosis of complex anal fistula according to the American Gastroenterological Association classification The patients were divided into 2 groups; the "first time group" (Group I) in which micro-fragmented adipose tissue injection with closure of the internal opening was the first sphincter-saving procedure, and the "recurrent group" (Group II) consisting of patients who had failed prior sphincter-saving procedures. The procedure was carried out 4-6 weeks after seton placement. Follow-up visits were scheduled at 7 days, and 1, 3, 6 and 12 months after surgery. Fistula healing was defined as the closure of the internal and external openings without any discharge. Out of 47 patients with complex transsphincteric anal fistula, 19 met the inclusion criteria and were selected to undergo the procedure. Twelve of these patients (Group I) had micro-fragmented adipose tissue injection as first-line treatment, and 7 (Group II) had failed previous sphincter-saving procedures. The mean operative time was 55 ± 6 min (range 50-70 min). The mean postoperative pain score measured with the visual analog pain scale was 2 ± 1.4 (range 0-4). No intraoperative difficulties related to the use of the kit were recorded. There were no cases of postoperative fever or abdominal sepsis related to the procedure and no post-treatment perianal bleeding or impaired anal continence. Only 3 cases of minor abdominal wall hematoma that did not require any treatment and 1 case of perianal abscess were observed. Patients were evaluated for a mean follow-up time of 9 ± 3.1 months (range 3-12 months). The overall healing rate was 73.7, 83.3% for Group I and 57.1% for Group II. The injection of autologous, micro-fragmented and minimally manipulated adipose tissue associated with closure of the internal opening is a safe, feasible and reproducible procedure and may enhance complex anal fistula healing.

40 CFR 87.11 - Standard for fuel venting emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fuel venting emissions shall be discharged into the atmosphere from any new or in-use aircraft gas... discharge to the atmosphere of fuel drained from fuel nozzle manifolds after engines are shut down and does...

40 CFR 87.11 - Standard for fuel venting emissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... fuel venting emissions shall be discharged into the atmosphere from any new or in-use aircraft gas... discharge to the atmosphere of fuel drained from fuel nozzle manifolds after engines are shut down and does...

40 CFR 87.11 - Standard for fuel venting emissions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... fuel venting emissions shall be discharged into the atmosphere from any new or in-use aircraft gas... discharge to the atmosphere of fuel drained from fuel nozzle manifolds after engines are shut down and does...

DefenseLink.mil - Special Report - Travels With Gates

Science.gov Websites

International Security Assistance Force soldiers in Afghanistan to shut down drug networks that funnel money to Halt Taliban Drug Money BUDAPEST, Hungary, Oct. 9, 2008 - NATO should go after the drug trade in

Student Loans: A Slippery Lifeline.

ERIC Educational Resources Information Center

Bollag, Burton

2001-01-01

Discusses how, as more countries have instituted or increased tuition, student loans have spread. But the programs are a flop in much of the world, raising fears that many low-income people will be shut out of higher education. (EV)

46 CFR 56.97-38 - Initial service leak test (reproduces 137.7).

Code of Federal Regulations, 2014 CFR

2014-10-01

... is turbine extraction piping where shut-off valves are not available for isolating a line and where temporary closures are impractical. Others may be systems for service water, low pressure condensate, plant...

46 CFR 56.97-38 - Initial service leak test (reproduces 137.7).

Code of Federal Regulations, 2013 CFR

2013-10-01

... is turbine extraction piping where shut-off valves are not available for isolating a line and where temporary closures are impractical. Others may be systems for service water, low pressure condensate, plant...

46 CFR 56.97-38 - Initial service leak test (reproduces 137.7).

Code of Federal Regulations, 2011 CFR

2011-10-01

... is turbine extraction piping where shut-off valves are not available for isolating a line and where temporary closures are impractical. Others may be systems for service water, low pressure condensate, plant...

46 CFR 56.97-38 - Initial service leak test (reproduces 137.7).

Code of Federal Regulations, 2012 CFR

2012-10-01

... is turbine extraction piping where shut-off valves are not available for isolating a line and where temporary closures are impractical. Others may be systems for service water, low pressure condensate, plant...

As Universities Close Their Reactors, Energy Dept. Considers a Policy Shift.

ERIC Educational Resources Information Center

Southwick, Ron

2001-01-01

Discusses how, as many universities shut down their nuclear reactors used for research and training, the Energy Department considers moving its support to regional facilities, a change that might lead to more shutdowns. (EV)

Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors

NASA Astrophysics Data System (ADS)

Shetty, Anil; Elliott, Andrew M.; Schwartz, Jon A.; Wang, James; Esparza-Coss, Emilio; Klumpp, Sherry; Taylor, Brian; Hazle, John D.; Stafford, R. Jason

2008-02-01

This study investigates the potential of using gold nanoshells to mediate a thermally induced modulation of tumor vasculature in experimental prostate tumors. We demonstrate that after passive extravasation and retention of the circulating nanoshells from the tumor vasculature into the tumor interstitium, the enhanced nanoshells absorption of near-infrared irradiation over normal vasculature, can be used to increase tumor perfusion or shut it down at powers which result in no observable affects on tissue without nanoshells. Temperature rise was monitored in real time using magnetic resonance temperature imaging and registered with perfusion changes as extrapolated from MR dynamic contrast enhanced (DCE) imaging results before and after each treatment. Results indicate that nanoshell mediated heating can be used to improve perfusion and subsequently enhance drug delivery and radiation effects, or be used to shut down perfusion to assist in thermal ablative therapy delivery.

Drive to dismantle commerce department rolls on

NASA Astrophysics Data System (ADS)

Carlowicz, Michael

Late on November 7, Republican leaders of the House of Representatives tacked a measure to abolish the U.S. Department of Commerce onto a continuing resolution that keeps the federal government running and solvent while the fiscal 1996 budget debate continues. With the existing temporary funding measure expiring on November 13, congressional leaders were working to extend the budget again and to raise the national debt ceiling.The fate of the effort to terminate Commerce—which would eliminate the position of the Secretary of Commerce and shut down or transfer the department's programs to other departments—remained unclear at press time because Senate Republicans had not yet voiced support for the measure. The Clinton Administration has stated that the president would veto any attempt to shut down the Commerce Department; however, the link between the current dismantling measure and the continuing resolution to avert a government shutdown and financial default has further complicated the Administration's position.

Safety of laser use under the dental microscope.

PubMed

Saegusa, Hidetoshi; Watanabe, Satoshi; Anjo, Tomoo; Ebihara, Arata; Suda, Hideaki

2010-04-01

The aim of this study was to investigate the safety of laser use under the dental microscope. Nd:YAG, Er:YAG and diode lasers were used. The end of the tips was positioned at a distance of 5 cm from the objective lens of a dental microscope. Each eye protector was made into a flat disc, which was fixed on the lens of the microscope. The filters were placed in front of the objective lens or behind the eye lens. Transmitted energy through the microscope with or without the filters was measured. No transmitted laser energy was detected when using matched eye protectors. Mismatched eye protectors were not effective for shutting out laser energy, especially for Nd:YAG and diode lasers. None or very little laser energy was detected through the microscope even without any laser filter. Matched filters shut out all laser energy irrespective of their positions.

An overview of medical ECMO for neonates.

PubMed

Fletcher, Kathryn; Chapman, Rachel; Keene, Sarah

2018-03-01

Extracorporeal membrane oxygenation (ECMO), a life-saving therapy for respiratory and cardiac failure, was first used in neonates in the 1970s. The indications and criteria for ECMO have changed over the years, but it continues to be an important option for those who have failed other medical therapies. Since the Extracorporeal Life Support Organization (ELSO) Registry was established in 1989, more than 29,900 neonates have been placed on ECMO for respiratory failure, with 84% surviving their ECMO course, and 73% surviving to discharge or transfer. In this chapter, we will review the basics of ECMO, patient characteristics and criteria, patient management, ECMO complications, special uses of neonatal ECMO, and patient outcomes. Copyright © 2018 Elsevier Inc. All rights reserved.

Membrane electrode gasket assembly (MEGA) technology for polymer electrolyte fuel cells

NASA Astrophysics Data System (ADS)

Pozio, A.; Giorgi, L.; De Francesco, M.; Silva, R. F.; Lo Presti, R.; Danzi, A.

A new technology for the production of a membrane electrode gasket assembly (MEGA) for polymer electrolyte fuel cells (PEFCs) is defined. The MEGA system was prepared by sealing a previously prepared membrane electrode assembly (MEA) in a moulded gasket. For this aim, a proprietary silicone based liquid mixture was injected directly into the MEA borders. Gaskets obtained in different shapes and hardness grades are stable in a wide temperature range. The MEGA technology shows several advantages with respect to traditional PEFCs stack assembling systems: effective membrane saving, reduced fabrication time, possibility of quality control and failed elements substitution. This technology was successfully tested at the ENEA laboratories and the results were acquired in laboratory scale, but industrial production appears to be simple and cheap.

[Perioperative stroke following transurethral resection of prostate: high index of suspicion and stabilization of physiological parameters can save lives].

PubMed

Nag, Deb Sanjay; Chatterjee, Abhishek; Samaddar, Devi Prasad; Agarwal, Ajay

2017-01-09

We report a case of a 72 year old hypertensive male who developed severe hypertension followed by neurological deterioration in the immediate postoperative period after transurethral resection of prostate. While arterial blood gas and laboratory tests excluded transurethral resection of prostate syndrome or any other metabolic cause, reduction of blood pressure failed to ameliorate the symptoms. A cranial CT done 4hours after the onset of neurological symptoms revealed bilateral gangliocapsular and right thalamic infarcts. Oral aspirin was advised to prevent early recurrent stroke. Supportive treatment and mechanical ventilation ensured physiological stability and the patient recovered completely over the next few days without any residual neurological deficit. Copyright © 2016. Publicado por Elsevier Editora Ltda.

Clinical decision-making: the case against the new casuistry.

PubMed

Ananth, Mahesh

2017-01-01

Albert Jonsen and Stephen Toulmin have argued that the best way to resolve the complex issues in medical settings is to focus on the actual details of cases and then determine what to do in the given cases. This approach to medical decision-making, labeled "casuistry," has met with much criticism. In response, Carson Strong has attempted to save much of Jonsen and Toulmin's version of casuistry. This analysis reveals that Strong's recent salvage efforts fail to deflect the major criticisms. The upshot of this analysis is that Jonsen and Toulmin's version of casuistry is not an appropriate framework from which to resolve complex issues in clinical settings. Copyright © 2017 by the National Legal Center for the Medically Dependent and Disabled, Inc.

Morphological Variation and Recovery Mechanism of Residual Crude Oil by Biosurfactant from Indigenous Bacteria: Macro- and Pore-Scale Experimental Investigations.

PubMed

Song, Zhi-Yong; Han, Hong-Yan; Zhu, Wei-Yao

2015-06-01

Microbial enhanced oil recovery (MEOR) is being used more widely, and the biological contributions involved in MEOR need to be identified and quantified for the improvement of field applications. Owing to the excellent interfacial activity and the wide distribution of producing strains in oil reservoirs, lipopeptides have proved to be an essential part of the complex mechanisms in MEOR. In this study, crude lipopeptides were produced by a strain isolated from an indigenous community in an oil reservoir. It was found that crude lipopeptides can effectively reduce the IFT (interfacial tension) to 10(-1)~10(-2) mN/m under high salinity without forming stable emulsions, and the wettability of natural sandstone can be enhanced (Amott index, from 0.36 to 0.48). The results of core flooding experiments indicate that an additional 5.2% of original oil in place can be recovered with a 9.5% reduction of injection pressure. After the shut-in period, the wettability of the core, the reduction of injection pressure, and the oil recovery can be improved to 0.63, 16.2% and 9.6%, respectively. In the microscopic flooding experiments, the crude oil in membrane, cluster, and throat states contribute nearly 90% in total of the additional oil recovery, and the recovery of membranestate oil was significantly enhanced by 93.3% after shut in. Based on the results in macro and pore scale, the IFT reduction and the wettability alteration are considered primary contributors to oil recovery, while the latter was more dominant after one shut-in period.

Optimized dispatch in a first-principles concentrating solar power production model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, Michael J.; Newman, Alexandra M.; Hamilton, William T.

Concentrating solar power towers, which include a steam-Rankine cycle with molten salt thermal energy storage, is an emerging technology whose maximum effectiveness relies on an optimal operational and dispatch policy. Given parameters such as start-up and shut-down penalties, expected electricity price profiles, solar availability, and system interoperability requirements, this paper seeks a profit-maximizing solution that determines start-up and shut-down times for the power cycle and solar receiver, and the times at which to dispatch stored and instantaneous quantities of energy over a 48-h horizon at hourly fidelity. The mixed-integer linear program (MIP) is subject to constraints including: (i) minimum andmore » maximum rates of start-up and shut-down, (ii) energy balance, including energetic state of the system as a whole and its components, (iii) logical rules governing the operational modes of the power cycle and solar receiver, and (iv) operational consistency between time periods. The novelty in this work lies in the successful integration of a dispatch optimization model into a detailed techno-economic analysis tool, specifically, the National Renewable Energy Laboratory's System Advisor Model (SAM). The MIP produces an optimized operating strategy, historically determined via a heuristic. Using several market electricity pricing profiles, we present comparative results for a system with and without dispatch optimization, indicating that dispatch optimization can improve plant profitability by 5-20% and thereby alter the economics of concentrating solar power technology. While we examine a molten salt power tower system, this analysis is equally applicable to the more mature concentrating solar parabolic trough system with thermal energy storage.« less

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

7. SOUTHEAST PENSTOCK ENTERING RECEIVER ON NORTHEAST SIDE OF SAR1, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. SOUTHEAST PENSTOCK ENTERING RECEIVER ON NORTHEAST SIDE OF SAR-1, ALSO SHOWING TURBINE SHUT OFF VALVES AND ISOLATION VALVE. VIEW TO WEST. - Santa Ana River Hydroelectric System, SAR-1 Powerhouse, Redlands, San Bernardino County, CA

Heart Valve Diseases

MedlinePlus

Your heart has four valves. Normally, these valves open to let blood flow through or out of your heart, and then shut to keep it from flowing ... close tightly. It's one of the most common heart valve conditions. Sometimes it causes regurgitation. Stenosis - when ...

76 FR 48855 - Questar Pipeline Company; Notice of Request Under Blanket Authorization

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... gas to be stored at its Clay Basin storage reservoir and increase the maximum certificated shut-in pressure of Clay Basin located in Daggett County, Utah. The request was made pursuant to the blanket...

The climate mitigation gap: education and government recommendations miss the most effective individual actions

NASA Astrophysics Data System (ADS)

Wynes, Seth; Nicholas, Kimberly A.

2017-07-01

Current anthropogenic climate change is the result of greenhouse gas accumulation in the atmosphere, which records the aggregation of billions of individual decisions. Here we consider a broad range of individual lifestyle choices and calculate their potential to reduce greenhouse gas emissions in developed countries, based on 148 scenarios from 39 sources. We recommend four widely applicable high-impact (i.e. low emissions) actions with the potential to contribute to systemic change and substantially reduce annual personal emissions: having one fewer child (an average for developed countries of 58.6 tonnes CO2-equivalent (tCO2e) emission reductions per year), living car-free (2.4 tCO2e saved per year), avoiding airplane travel (1.6 tCO2e saved per roundtrip transatlantic flight) and eating a plant-based diet (0.8 tCO2e saved per year). These actions have much greater potential to reduce emissions than commonly promoted strategies like comprehensive recycling (four times less effective than a plant-based diet) or changing household lightbulbs (eight times less). Though adolescents poised to establish lifelong patterns are an important target group for promoting high-impact actions, we find that ten high school science textbooks from Canada largely fail to mention these actions (they account for 4% of their recommended actions), instead focusing on incremental changes with much smaller potential emissions reductions. Government resources on climate change from the EU, USA, Canada, and Australia also focus recommendations on lower-impact actions. We conclude that there are opportunities to improve existing educational and communication structures to promote the most effective emission-reduction strategies and close this mitigation gap.

Cost-effectiveness of retreatment with varenicline after failure with or relapse after initial treatment for smoking cessation

PubMed Central

Annemans, Lieven; Marbaix, Sophie; Nackaerts, Kristiaan; Bartsch, Pierre

2015-01-01

Objectives A recent trial showed the clinical benefit of retreatment with varenicline in subjects failing on the initial treatment, or relapsing after initial success. The objective of this study was to evaluate the cost-effectiveness of retreatment with varenicline compared with other smoking cessation interventions. Methods A published Markov model was adapted to compare one quit attempt of varenicline followed by retreatment to treatment/retreatment with nicotine replacement therapy (NRT), bupropion or placebo, and with only 1 quit attempt of varenicline. Efficacy was obtained from clinical trials. Incidence of smoking-related diseases was based on published data. Cost of therapies and complications was obtained from databases and literature. Results For 1000 smokers willing to quit, varenicline retreatment saves 275,000€, 118,000€, 316,000€ and 237,000€ compared to NRT, bupropion, placebo, or one single varenicline quit attempt respectively at lifetime and from the healthcare payer perspective. The number of quality adjusted life years gained is 74, 63, 193 and 111 respectively. Sensitivity analyses showed the robustness of these findings. Conclusion This analysis suggests that in the long term, varenicline retreatment is a dominant intervention, meaning both greater health gains and greater costs saved, over other possible interventions and therefore should be considered as a standard option. PMID:26844072

Emergency department triage: an ethical analysis

PubMed Central

2011-01-01

Background Emergency departments across the globe follow a triage system in order to cope with overcrowding. The intention behind triage is to improve the emergency care and to prioritize cases in terms of clinical urgency. Discussion In emergency department triage, medical care might lead to adverse consequences like delay in providing care, compromise in privacy and confidentiality, poor physician-patient communication, failing to provide the necessary care altogether, or even having to decide whose life to save when not everyone can be saved. These consequences challenge the ethical quality of emergency care. This article provides an ethical analysis of "routine" emergency department triage. The four principles of biomedical ethics - viz. respect for autonomy, beneficence, nonmaleficence and justice provide the starting point and help us to identify the ethical challenges of emergency department triage. However, they do not offer a comprehensive ethical view. To address the ethical issues of emergency department triage from a more comprehensive ethical view, the care ethics perspective offers additional insights. Summary We integrate the results from the analysis using four principles of biomedical ethics into care ethics perspective on triage and propose an integrated clinically and ethically based framework of emergency department triage planning, as seen from a comprehensive ethics perspective that incorporates both the principles-based and care-oriented approach. PMID:21982119

Evaluating the Use of Tissue Oximetry to Decrease Intensive Unit Monitoring for Free Flap Breast Reconstruction.

PubMed

Ricci, Joseph A; Vargas, Christina R; Ho, Olivia A; Lin, Samuel J; Tobias, Adam M; Lee, Bernard T

2017-07-01

Postoperative free flap care has historically required intensive monitoring for 24 hours in an intensive care unit. Continuous monitoring with tissue oximetry has allowed earlier detection of vascular compromise, decreasing flap loss and improving salvage. This study aims to identify whether a fast-track postoperative paradigm can be safely used with tissue oximetry to decrease intensive monitoring and costs. All consecutive microsurgical breast reconstructions performed at a single institution were reviewed (2008-2014) and cases requiring return to the operating room were identified. Data evaluated included patient demographics, the take back time course, and complications of flap loss and salvage. A cost-benefit analysis was performed to analyse the utility of a postoperative intensive monitoring setting. There were 900 flaps performed and 32 required an unplanned return to the operating room. There were 16 flaps that required a reexploration within the first 24 hours; the standard length of intensive unit monitoring. After 4 hours, there were 7 flaps (44%) detected by tissue oximetry for reexploration. After 15 hours of intensive monitoring postoperatively, cost analysis revealed that the majority (15/16; 94%) of failing flaps had been identified and the cost of identifying each subsequent failing flap exceeded the cost of another hour of intensive monitoring. The postoperative paradigm for microsurgical flaps has historically required intensive unit monitoring. Using tissue oximetry, a fast-track pathway can reduce time spent in an intensive monitoring setting from 24 to 15 hours with significant cost savings and minimal risk of missing a failing free flap.

76 FR 60373 - Approval and Promulgation of Air Quality Implementation Plans; Ohio, Kentucky, and Indiana...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

..., 77 West Jackson Boulevard, Chicago, Illinois 60604-3507. Mr. Summerhays' telephone number is (312... granted for the site to be shut down because the Carthage Fire site registered a higher design value and...

Doodlefunking.

ERIC Educational Resources Information Center

Fishman, Jerry

"Doodlefunking" is a useful method for motivating students to produce creative language products: "doodle" suggests aimless drawing directed by the unconscious while the conscious is attending to other matters, and "funking" connotes moving into a mental state in which the conscious mind is shut off while the…

Earthshots: Satellite images of environmental change – Chernobyl, Ukraine

USGS Publications Warehouse

,

2013-01-01

The Landsat 5 image from April 29, 1986, was the first satellite image of the accident. The data from Landsat were used to help confirm that an explosion had happened at Chernobyl and that the plant had been shut down.

78 FR 23546 - Proposed Extension of Approval of Information Collection; Comment Request: Virginia Graeme Baker...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

..., 2011. In addition to the anti-entrapment devices or systems, each public pool and spa in the United... release system; suction-limiting vent system; gravity drainage system; automatic pump shut-off system or...

Updating the National School Lunch Program.

ERIC Educational Resources Information Center

Plewes, Margaretta S.

1983-01-01

Despite a favorable nationwide evaluation of school nutrition programs, budget cuts have forced 3,000 schools to shut down their lunch programs. The American School Food Service Association has organized an effective campaign to forestall additional cuts and reestablish program support. (MLF)

30 CFR 253.10 - What facilities does this part cover?

Code of Federal Regulations, 2010 CFR

2010-07-01

... granted under the OCSLA or applicable state law. (b) For a pipeline COF that extends onto land, this part applies to that portion of the pipeline lying seaward of the first accessible flow shut-off device on land. ...

Gastrointestinal and renal responses to variable water intake in whitebellied sunbirds and New Holland honeyeaters.

PubMed

Purchase, Cromwell; Napier, Kathryn R; Nicolson, Susan W; McWhorter, Todd J; Fleming, Patricia A

2013-05-01

Nectarivores face a constant challenge in terms of water balance, experiencing water loading or dehydration when switching between food plants or between feeding and fasting. To understand how whitebellied sunbirds and New Holland honeyeaters meet the challenges of varying preformed water load, we used the elimination of intramuscular-injected [(14)C]-l-glucose and (3)H2O to quantify intestinal and renal water handling on diets varying in sugar concentration. Both sunbirds and honeyeaters showed significant modulation of intestinal water absorption, allowing excess water to be shunted through the intestine when on dilute diets. Despite reducing their fractional water absorption, both species showed linear increases in water flux and fractional body water turnover as water intake increased (both afternoon and morning), suggesting that the modulation of fractional water absorption was not sufficient to completely offset dietary water loads. In both species, glomerular filtration rate was independent of water gain (but was higher for the afternoon), as was renal fractional water reabsorption (measured in the afternoon). During the natural overnight fast, both sunbirds and honeyeaters arrested whole kidney function. Evaporative water loss in sunbirds was variable but correlated with water gain. Both sunbirds and honeyeaters appear to modulate intestinal water absorption as an important component of water regulation to help deal with massive preformed water loads. Shutting down glomerular filtration rate during the overnight fast is another way of saving energy for osmoregulatory function. Birds maintain osmotic balance on diets varying markedly in preformed water load by varying both intestinal water absorption and excretion through the intestine and kidneys.

Will this open space work?

PubMed

Vischer, J

1999-01-01

Northern Oil is moving offices, and CEO Fritz Schumacher wants to make the most of the move in this fictional case study. He believes that adopting an open-plan work space will reinvent how the company works, not to mention cut costs. Facilities manager Sasha Pasternak also supports the open plan. Her job would be easier, and her budget would stretch further, if Northern had standardized workstations and used partitions, not walls. And she likes the way the new design flattens the organization: everyone has the same amount of space and the same ergonomically sound furniture. The new building would have more conference rooms and just-in-time work spaces for employees who worked mostly off-site. And although she knew that initial meetings between the architects and Northern employees hadn't yielded much support for open space--people were attached to their private offices--she expected that people would warm to the idea. But when the new design was unveiled, employees were less than enthusiastic. They hurled questions like, How will workers concentrate if they can't shut their office doors? How will people have confidential meetings with their boss? And why would people stay at Northern when the competition offers them private offices? There was even talk of circulating a petition refusing to move to the new space. A week later, the architect presented revised plans to the project group. The new options would add costs and reduce the amount of space savings, but offering a choice to employees might make them feel less threatened. What should the project team do? Five commentators offer advice.

USCYBERCOM: Right Solution, Wrong C2 Structure

DTIC Science & Technology

2012-05-04

March 26, 2012. 9 and literally, shutting the nation down and taking it off the global information grid ( GIG ). The would-be cyber terrorists...effective execution of approved OPLANs; effectiveness and economy of operation; and prevention or elimination of unnecessary duplication of facilities and

Fermilab | Tevatron | Accelerator

Science.gov Websites

Leading accelerator technology Accelerator complex Illinois Accelerator Research Center Fermilab temperature. They were used to transfer particles from one part of the Fermilab accelerator complex to another center ring of Fermilab's accelerator complex. Before the Tevatron shut down, it had three primary

75 FR 6018 - Boyce Hydro Power, LLC; Notice of Application for Amendment of License and Soliciting Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

.... d. Applicant: Boyce Hydro Power, LLC (BHP). e. Name of Project: Edenville Hydroelectric Project. f... construct the footings and first lift of the retaining walls. BHP states that shutting off the bypass flow...

Standardization of availability, location and use of safety equipment on urban transit buses

DOT National Transportation Integrated Search

1996-03-01

This document represents the conclusion of a project undertaken to identify guidelines which will correct the problems encountered by rescue forces while attempting to gain entry to, shut down, and evacuate urban transit buses involved in an emergenc...

A novel anti-theft security system for photovoltaic modules

NASA Astrophysics Data System (ADS)

Khan, Wasif Ali; Lim, Boon-Han; Lai, An-Chow; Chong, Kok-Keong

2017-04-01

Solar farms are considered as easy target for thieves because of insufficient protection measures. Existing anti-theft approaches are based on system level and are not very preventive and efficient because these can be bypassed with some technical knowledge. Additionally, it is difficult for security guards to tackle them as robbers come in a form of a gang equipped with heavy weapons. In this paper, a low power auto shut-off and non-destructive system is proposed for photovoltaic (PV) modules to achieve better level of security at module level. In proposed method, the power generation function of the PV module will be shut-off internally and cannot be re-activated by unauthorized personnel, in the case of theft. Hence, the PV module will not be functional even sold to new customers. The system comprises of a microcontroller, a low power position sensor, a controllable semiconductor switch and a wireless reactive-able system. The anti-theft system is developed to be laminated inside PV module and will be interconnected with solar cells so it becomes difficult for thieves to temper. The position of PV module is retrieved by position sensor and stored in a microcontroller as an initial reference value. Microcontroller uses this stored reference value to control power supply of PV module via power switch. The stored reference value can be altered using wireless circuitry by following authentication protocol. It makes the system non-destructive as anti-theft function can be reset again by authorized personnel, if it is recovered after theft or moved for maintenance purposes. The research component includes the design of a position sensing circuit, an auto shut-off circuit, a reactive-able wireless security protection algorithm and finally the integration of the multiple circuits.

Fiber/proppant mixtures control proppant flowback in South Texas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howard, P.R.; King, M.T.; Morris, M.

1995-12-31

Backproduction of proppant from hydraulic fractures (proppant flowback) is a continuing operational problem in the oil and gas industry. Up to 20% of the proppant can be flowed back after the treatment. Curable resin-coated proppants are used to control proppant production, but are known to chemically interact with fracturing fluids and may be prone to several failure mechanisms. Curable resin-coated proppants also require either well shut-in or the use of activators at low temperatures. A new method to control proppant flowback relies on fibers mixed with the proppant to stabilize the proppant pack. The main advantage of this patented technologymore » is that it is physical rather than chemical. Therefore, proppant flowback is controlled without specific shut-in time, temperature, or pressure constraints. This paper presents flowback results from fractures of dry gas wells (<1 millidarcy permeability) where fiber/proppant mixtures were used to control proppant flow-back (11 cases). Fluid flowback rate, gas rate and proppant production were monitored during the cleanup period. These wells are compared to wells where either curable resin-coated proppants or no flowback control were used (15 cases). The fiber/proppant mixtures controlled flowback of proppant for both sand and ceramic proppants when used with all the proppant or in only the last part of proppant (tail-in). Flowback could begin right after the fracturing equipment was rigged down (15 to 30 minutes). Cleanup fluid flow rates were up to ten times higher than previously obtainable with curable resin-coated proppants and less proppant was flowed back. Faster flowback rates also resulted in earlier onset of gas production and reduced flowback time. Fibers allow greater latitude in flowback rate than curable resin-coated proppants without the need for shut-in time.« less

Two-Phase Thermal Switching System for a Small, Extended Duration Lunar Surface Science Platform

NASA Technical Reports Server (NTRS)

Bugby, David C.; Farmer, Jeffery T.; OConnor, Brian F.; Wirzburger, Melissa J.; Abel, Elisabeth D.; Stouffer, Chuck J.

2010-01-01

This paper describes a novel thermal control system for the Warm Electronics Box (WEB) on board a small lunar surface lander intended to support science activities anywhere on the lunar surface for an extended duration of up to 6 years. Virtually all lander electronics, which collectively dissipate about 60 W in the reference mission, are contained within the WEB. These devices must be maintained below 323 K (with a goal of 303 K) during the nearly 15-earth-day lunar day, when surface temperatures can reach 390K, and above 263 K during the nearly 15-earth-day lunar night, when surface temperatures can reach 100K. Because of the large temperature swing from lunar day-to-night, a novel thermal switching system was required that would be able to provide high conductance from WEB to radiator(s) during the hot lunar day and low (or negligible) conductance during the cold lunar night. The concept that was developed consists of ammonia variable conductance heat pipes (VCHPs) to collect heat from WEB components and a polymer wick propylene loop heat pipe (LHP) to transport the collected heat to the radiator(s). The VCHPs autonomously maximize transport when the WEB is warm and autonomously shut down when the WEB gets cold. The LHP autonomously shuts down when the VCHPs shut down. When the environment transitions from lunar night to day, the VCHPs and LHP autonomously turn back on. Out of 26 analyzed systems, this novel arrangement was able to best achieve the combined goals of zero control power, autonomous operation, long life, low complexity, low T, and landed tilt tolerance.

Seismicity rate surge on faults after shut-in: poroelastic response to fluid injection

NASA Astrophysics Data System (ADS)

Chang, K. W.; Yoon, H.; Martinez, M. J.

2017-12-01

Subsurface energy activities such as geological CO2 storage and wastewater injection require injecting large amounts of fluid into the subsurface, which will alter the states of pore pressure and stress in the storage formation. One of the main issues for injection-induced seismicity is the post shut-in increases in the seismicity rate, often observed in the fluid-injection operation sites. The rate surge can be driven by the following mechanisms: (1) pore-pressure propagation into distant faults after shut-in and (2) poroelastic stressing caused by well operations, depending on fault geometry, hydraulic and mechanical properties of the formation, and injection history. We simulate the aerial view of the target reservoir intersected by strike-slip faults, in which injection-induced pressure buildup encounters the faults directly. We examine the poroelastic response of the faults to fluid injection and perform a series of sensitivity tests considering: (1) permeability of the fault zone, (2) locations and the number of faults with respect to the injection point, and (3) well operations with varying the injection rate. Our analysis of the Coulomb stress change suggests that the sealing fault confines pressure diffusion which stabilizes or weakens the nearby conductive fault depending on the injection location. We perform the sensitivity test by changing injection scenarios (time-dependent rates), while keeping the total amount of injected fluids. Sensitivity analysis shows that gradual reduction of the injection rate minimizes the Coulomb stress change and the least seismicity rates are predicted. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia, LLC., a wholly owned subsidiary of Honeywell International, Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA-0003525.

The X-38 Spacecraft Fault-Tolerant Avionics System

NASA Technical Reports Server (NTRS)

Kouba,Coy; Buscher, Deborah; Busa, Joseph

2003-01-01

In 1995 NASA began an experimental program to develop a reusable crew return vehicle (CRV) for the International Space Station. The purpose of the CRV was threefold: (i) to bring home an injured or ill crewmember; (ii) to bring home the entire crew if the Shuttle fleet was grounded; and (iii) to evacuate the crew in the case of an imminent Station threat (i.e., fire, decompression, etc). Built at the Johnson Space Center, were two approach and landing prototypes and one spacecraft demonstrator (called V201). A series of increasingly complex ground subsystem tests were completed, and eight successful high-altitude drop tests were achieved to prove the design concept. In this program, an unprecedented amount of commercial-off-the-shelf technology was utilized in this first crewed spacecraft NASA has built since the Shuttle program. Unfortunately, in 2002 the program was canceled due to changing Agency priorities. The vehicle was 80% complete and the program was shut down in such a manner as to preserve design, development, test and engineering data. This paper describes the X-38 V201 fault-tolerant avionics system. Based on Draper Laboratory's Byzantine-resilient fault-tolerant parallel processing system and their "network element" hardware, each flight computer exchanges information on a strict timescale to process input data, compare results, and issue voted vehicle output commands. Major accomplishments achieved in this development include: (i) a space qualified two-fault tolerant design using mostly COTS (hardware and operating system); (ii) a single event upset tolerant network element board, (iii) on-the-fly recovery of a failed processor; (iv) use of synched cache; (v) realignment of memory to bring back a failed channel; (vi) flight code automatically generated from the master measurement list; and (vii) built in-house by a team of civil servants and support contractors. This paper will present an overview of the avionics system and the hardware implementation, as well as the system software and vehicle command & telemetry functions. Potential improvements and lessons learned on this program are also discussed.

Advanced manufacturing development of a composite empennage component for L-1011 aircraft. Phase 2: Design and analysis

NASA Technical Reports Server (NTRS)

Jackson, A. C.; Crocker, J. F.; Ekvall, J. C.; Eudaily, R. R.; Mosesian, B.; Vancleave, R. R.; Vanhamersveld, J.

1981-01-01

The composite fin design consists of two one-piece cocured covers, two one-piece cocured spars and eleven ribs. The lower ribs are truss ribs with graphite/epoxy caps and aluminum truss members. The upper three ribs are a sandwich design with graphite/epoxy face sheets and a syntactic epoxy core. The design achieves a 27% weight saving compared to the metal box. The fastener count has been reduced from over 40,000 to less than 7000. The structural integrity of the composite fin was verified by analysis and test. The static, fail-safe and flutter analyses were completed. An extensive test program has established the material behavior under a range of conditions and critical subcomponents were tested to verify the structural concepts.

New Understanding of Hubble Space Telescope Gyro Current Increase Led to a Method to Save a Failing Gyro

NASA Technical Reports Server (NTRS)

Blumenstock, Kenneth A.

2017-01-01

Throughout the history of the Hubble Space Telescope (HST) program, gyro current increases have been observed to occur, oftentimes leading to gyro failure. The explanation was that debris from the surfaces of the gas bearings, with only 50 millionths on an inch clearance, resulted in rotor restriction, which increased friction, torque, and current. However, the rotor restriction theory never could account for the fact that a restart of the gyro would restore the current back to nominal. An effort was made to understand this puzzling gyro behavior after two HST gyros exhibited increased current within the same week in November 2015. A review board was created to resolve these anomalies and generate operational procedures to potentially extend gyro life.

Discount medical cards: innovation or illusion?

PubMed

Kofman, Mila; Libster, Jennifer; Bangit, Eliza

2005-03-01

Discount medical cards have come under increasing scrutiny by regulators and law enforcement officials as a result of mounting consumer-reported problems. For their study, the authors tested five cards available in the Washington, D.C., metro area; interviewed card company representatives, state attorneys general insurance regulators, and insurance agents; and reviewed court and administrative actions. While some cards provide a measure of value, other cards were found to have serious drawbacks, including: high-pressure sales tactics; misleading or inaccurate promotion; exaggerated claims of savings; difficulty finding participating doctors; and providers who failed to give cardholders promised discounts. Some discount card companies are seeking to reform the market through a trade association and voluntary code of conduct. Still, legislative and regulatory interventions will be needed to protect consumers in an unregulated and growing market.

Preconception care: an essential preventive strategy to improve children's and women's health.

PubMed

van der Zee, Boukje; de Beaufort, Inez; Temel, Sevilay; de Wert, Guido; Denktas, Semiha; Steegers, Eric

2011-08-01

Reproductive health has improved little in the last few decades. The Netherlands, particularly in large cities, has relatively high perinatal death rates compared with other European countries. Lack of improvement in reproductive outcomes despite improved quality of and better access to prenatal care strongly suggests that prenatal care alone is insufficient. We discuss how preconception care offers new strategies for improving reproductive health, how it usefully connects the life course of the affected individual and many health-care disciplines, and the benefits of combining a top-down policy structure and bottom-up organisation around caregivers. Given the likely benefits and cost savings calculated for The Netherlands, we conclude that failing to facilitate preconception care would reflect a breakdown of both professional and governmental responsibilities.

Application study of filamentary composites in a commercial jet aircraft fuselage

NASA Technical Reports Server (NTRS)

Johnson, R. W.; June, R. R.

1972-01-01

A study of applications of filamentary composite materials to aircraft fuselage structure was performed. General design criteria were established and material studies conducted using the 727-200 forebody as the primary structural component. Three design approaches to the use of composites were investigated: uniaxial reinforcement of metal structure, uniaxial and biaxial reinforcement of metal structure, and an all-composite design. Materials application studies for all three concepts were conducted on fuselage shell panels, keel beam, floor beams, floor panels, body frames, fail-safe straps, and window frames. Cost benefit studies were conducted and developmental program costs estimated. On the basis of weight savings, cost effectiveness, developmental program costs, and potential for early application on commercial aircraft, the unaxial design is recommended for a 5-year flight service evaluation program.

Letter: California's position on pregnancy testing.

PubMed

Cunningham, G C

1976-07-01

The dangers of do-it-yourself pregnancy testing have been recognized in California resulting in the passing of legislation. Pregnancy is a c ondition which requires skill, medical assistance, and occasionally inte rvention or objective counseling. There are 4 arguments against do-it-y ourself testing: 1) it may be inaccurate or inexpertly done, 2) reagents can be hazardous to the health of users or small children, 3) it fails to save money because confirmation by health professionals is usually required, and 4) the individual may not have access to appropriate healt h care resources. California counties have been providing an increasing volume of tests that have served to encourage earlier prenatal care, earlier and safer pregnancy termination, or attendance at family planning clinics. The success of this program warrants implementation by other state governments.

Accounting for Proof Test Data in a Reliability Based Design Optimization Framework

NASA Technical Reports Server (NTRS)

Ventor, Gerharad; Scotti, Stephen J.

2012-01-01

This paper investigates the use of proof (or acceptance) test data during the reliability based design optimization of structural components. It is assumed that every component will be proof tested and that the component will only enter into service if it passes the proof test. The goal is to reduce the component weight, while maintaining high reliability, by exploiting the proof test results during the design process. The proposed procedure results in the simultaneous design of the structural component and the proof test itself and provides the designer with direct control over the probability of failing the proof test. The procedure is illustrated using two analytical example problems and the results indicate that significant weight savings are possible when exploiting the proof test results during the design process.

Tidd hot gas clean up program. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This Final Report on the Tidd Hot Gas Clean Up Program covers the period from initial Proof-of-Concept testing in August, 1990, through final equipment inspections in May, 1995. The Tidd Hot Gas Clean Up (HGCU) system was installed in the Tidd Pressurized Fluidized Bed Combustion (PFBC) Demonstration Plant, which is the first utility-scale PFBC plant in the United States. Detailed design work on the project began in July, 1990, and site construction began in December, 1991. Initial operation of the system occurred in May, 1992, and the hot gas filter was commissioned in October, 1992. The test program ended inmore » March, 1995, when the Tidd Plant was shut down following its four-year test program. Section 1.0 of this report is an executive summary of the project covering the project background, system description, test results and conclusions. Section 2.0 is an introduction covering the program objectives and schedule. Section 3.0 provides detailed descriptions of the system and its major components. Section 4.0 provides detailed results of all testing including observations and posttest inspection results. Sections 5.0 and 6.0 list the program conclusions and recommendations, respectively. Appendix I is a report prepared by Southern Research Institute on the properties of Tidd PFBC ash sampled during the test program. Appendix II is a report prepared by Westinghouse STC on the performance of candle filter fail-safe regenerator devices.« less

New emission controls for Missouri batch-type charcoal kilns

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yronwode, P.; Graf, W.J.

1999-07-01

Charcoal kilns have been exempted from air emission regulation in the state of Missouri. Today, 80% of US charcoal production takes place in Missouri. As a result of a petition filed by people in the area around an installation in southern Missouri, the US Environmental Protection Agency (EPA) set up air monitors and measured ambient air levels at that charcoal manufacturing installation. These monitors yielded the highest particulate matter less than 10 micron (PM{sub 10}) levels ever recorded in the state. Earlier stack testing at another charcoal manufacturing installation indicated that toxics and carcinogens are present in charcoal kiln airmore » emissions. A Charcoal Kiln Workgroup was formed to determine the Best Available Control Technology (BACT) for charcoal kilns and to draft a charcoal kiln rule that requires BACT. The BACT report determined that afterburners were suitable for controlling emissions from batch-type charcoal kilns. In addition, the charcoal industry supported incorporating the BACT limits and requirements into an enforceable state rule and submitting this rule to the EPA for federal approval. A consent agreement between the EPA and three major charcoal companies was signed with provisions to install, operate, and maintain emission control devices on charcoal kilns. This agreement was to settle complaints alleging that the three major charcoal producers had failed to report toxic air emissions to federal and state regulators. The agreement provided that industry would install control devices on a set schedule with some charcoal kilns being shut down.« less

Subsurface fluid pressures from drill-stem tests, Uinta Basin, Utah

USGS Publications Warehouse

Nelson, P.H.

2002-01-01

High fluid pressures are known to be associated with oil and gas fields in the Uinta Basin, Utah. Shut-in pressure measurements from drill-stem tests show how pressure varies with depth and by area within the basin. The data base used in this report incorporates over 2,000 pressure measurements from drill-stem tests in wells completed prior to 1985. However, the number of useful pressure measurements is considerably less, because many drill-stem tests fail to stabilize at the actual formation pressure if the permeability is low. By extracting the maximum pressure measurements recorded in a collection of wells within an area, the trend of formation pressure within that area can be approximated. Areal compilations of pressures from drill-stem tests show that overpressured rock formations occur throughout much of the northern and eastern areas of the Uinta Basin. In particular, significant overpressuring (0.5 < pressure gradient < 0.8 psi/ft) is found throughout much of the Altamont-Bluebell field at depths ranging from 10,000 to 13,000 ft, equivalent to 5,000 to 8,000 ft below sea level. Limited data indicate that the pressure gradient declines at depths greater than 13,000 ft. An underpressured zone appears to exist in the Altamont-Bluebell field at depths shallower than 5,000 ft. Throughout the eastern Uinta Basin, moderately overpressured zones (0.46 < pressure gradient < 0.5 psi/ft) are common, with local evidence of significantly overpressured zones, but pressure gradients greater than 0.6 psi/ft are rare.

47 CFR 15.611 - General technical requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false General technical requirements. 15.611 Section 15.611 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Access... shut-off procedure, by the use of a non-volatile memory, or some other method, to immediately restore...

Evaluation of Composite-Hull Ships Operating in Arctic Ice

DTIC Science & Technology

2016-06-01

controller. During the time of thesis submission, public works closed the NPS tow tank spaces for environmental characterization of asbestos , as shown...environmental characterization of asbestos shut down the Halligan Hall tow tank spaces. This prevented the researcher to fully assemble the wave generating

49 CFR 229.101 - Engines.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Engines. 229.101 Section 229.101 Transportation... Engines. (a) The temperature and pressure alarms, controls and related switches of internal combustion engines shall function properly. (b) Whenever an engine has been shut down due to mechanical or other...

Recent advances in sustainable winter road operations – a book proposal.

DOT National Transportation Integrated Search

2017-05-05

Investing in winter transportation operations is essential and beneficial to the public and the economy. The U.S. economy cannot afford the cost of shutting down highways, airports, etc., during winter weather. In the northern U.S. and other cold-cli...

Crewmember repairing the Regenerative Carbon Dioxide Removal System wiring.

NASA Technical Reports Server (NTRS)

1992-01-01

Mission Pilot Ken Bowersox, busy at work on the wiring harness for the Regenerative Carbon Dioxide Removal System located under the mid deck floor. Photo shows Bowersox splicing wires together to 'fool' a faulty sensor that caused the 'air conditioner' to shut down.

14 CFR 23.1145 - Ignition switches.

Code of Federal Regulations, 2011 CFR

2011-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 23.1145 Ignition switches. (a) Ignition switches must control and shut off each ignition circuit... the grouping of switches or by a master ignition control. (c) Each group of ignition switches, except...

14 CFR 23.1145 - Ignition switches.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 23.1145 Ignition switches. (a) Ignition switches must control and shut off each ignition circuit... the grouping of switches or by a master ignition control. (c) Each group of ignition switches, except...

14 CFR 23.1145 - Ignition switches.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 23.1145 Ignition switches. (a) Ignition switches must control and shut off each ignition circuit... the grouping of switches or by a master ignition control. (c) Each group of ignition switches, except...

14 CFR 23.1145 - Ignition switches.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 23.1145 Ignition switches. (a) Ignition switches must control and shut off each ignition circuit... the grouping of switches or by a master ignition control. (c) Each group of ignition switches, except...

14 CFR 23.1145 - Ignition switches.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 23.1145 Ignition switches. (a) Ignition switches must control and shut off each ignition circuit... the grouping of switches or by a master ignition control. (c) Each group of ignition switches, except...

49 CFR 229.101 - Engines.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Engines. 229.101 Section 229.101 Transportation... Engines. (a) The temperature and pressure alarms, controls and related switches of internal combustion engines shall function properly. (b) Whenever an engine has been shut down due to mechanical or other...

49 CFR 229.101 - Engines.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Engines. 229.101 Section 229.101 Transportation... Engines. (a) The temperature and pressure alarms, controls and related switches of internal combustion engines shall function properly. (b) Whenever an engine has been shut down due to mechanical or other...

49 CFR 229.101 - Engines.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Engines. 229.101 Section 229.101 Transportation... Engines. (a) The temperature and pressure alarms, controls and related switches of internal combustion engines shall function properly. (b) Whenever an engine has been shut down due to mechanical or other...

49 CFR 229.101 - Engines.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Engines. 229.101 Section 229.101 Transportation... Engines. (a) The temperature and pressure alarms, controls and related switches of internal combustion engines shall function properly. (b) Whenever an engine has been shut down due to mechanical or other...

77 FR 16919 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

... door from opening. It was found that the existing airstair door pneumatic shut-off valve control logic... Control Logic Change] to prevent the above-mentioned failure conditions. You may obtain further... Off Valve Control Logic Change, in accordance with the Accomplishment Instructions of Bombardier...

International Education: Putting Up or Shutting Up.

ERIC Educational Resources Information Center

Hayden, Rose L.

The current status, problems, and future trends of education for global awareness are outlined. Currently, global realities and interdependencies are such that traditional assumptions about international affairs and education are no longer operative. Nor is international education as a discipline conceptually or structurally responding to…

Gas Control System for HEAO-B

NASA Technical Reports Server (NTRS)

Taylor, B.; Brissette, R.; Humphrey, A.; Morris, J.; Luger, J.; Swift, W.

1978-01-01

The HEAO-B Gas Control System consists of a high pressure gas storage supply together with distribution and regulation assemblies and their associated electronics for management of gas required for HEAO-B X-ray counter experiments. The Gas Control System replenishes a gas mixture (82 percent argon, 12.3 percent carbon dioxide, 5.7 percent xenon) in the counter volumes which is lost by: diffusion through controlled leakage plugs, diffusion through counter windows, and consumption resulting from periodic purges. The gas density in each counter volume is maintained constant to within 0.25 percent by comparison with a sealed reference volume. The system is fully redundant, capable of operating at atmospheric pressure as well as in a vacuum, contains interlocks which shut down gas flow in the event of either leakage or excessive pressure, and is able to shut down counter high voltage if counter pressure is abnormally low. The system is electronically controlled by ground command and self-sustaining in orbit for a period of at least one year.

Medical consequences of a factory closure: illness and disability in a four-year follow-up study.

PubMed

Westin, S; Norum, D; Schlesselman, J J

1988-03-01

The effect of a factory shut-down on sick leave and disability pensions was investigated in a four-year controlled follow-up study in a general practice setting. The study population consisted of 85 people, 72 women and 13 men, who lost their jobs when a sardine factory near Bergen in Norway was shut down in 1975. The employees of a nearby sister factory' within the same company were chosen as a control population, consisting of 87 people, 66 women and 21 men. The average amount of sick leave for the study group within the first year of follow-up showed a twofold increase compared to the controls. The rate of disability pensions, estimated by the life table method with appropriate adjustments, was more than three times higher in the study group than in the control group from the second through the fourth year of follow-up. The results of this investigation provide further evidence in support of a causal relationship between job loss and illness.

Fast shut-down protection system for radio frequency breakdown and multipactor testing.

PubMed

Graves, T P; Hanson, P; Michaelson, J M; Farkas, A D; Hubble, A A

2014-02-01

Radio frequency (RF) breakdown such as multipactor or ionization breakdown is a device-limiting phenomenon for on-orbit spacecraft used for communication, navigation, or other RF payloads. Ground testing is therefore part of the qualification process for all high power components used in these space systems. This paper illustrates a shut-down protection system to be incorporated into multipactor/ionization breakdown ground testing for susceptible RF devices. This 8 channel system allows simultaneous use of different diagnostic classes and different noise floors. With initiation of a breakdown event, diagnostic signals increase above a user-specified level, which then opens an RF switch to eliminate RF power from the high power amplifier. Examples of this system in use are shown for a typical setup, illustrating the reproducibility of breakdown threshold voltages and the lack of multipactor conditioning. This system can also be utilized to prevent excessive damage to RF components in tests with sensitive or flight hardware.

Armored umbilical apparatus for towing a marine seismic air gun sub array

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burrage, E.C.

1985-06-25

An armored umbilical and termination housing is disclosed for towing a sub-array of seismic air guns used in marine seismic surveying comprising a single air hose for supplying all the high pressure air to the individual air guns surrounded by all the electrical control cables needed to operate the air guns in the sub-array. Protective coatings are applied around the electrical control cables and stress members for carrying the load of towing the sub-array are incorporated within the umbilical. A termination housing is provided on the end of the umbilical for terminating the single air hose and all the electricalmore » control lines to common connectors so that individual electrical control lines and air hoses can run from the termination housing to each individual air gun in the sub-array. Air shut off valves are provided so that the high pressure air can be shut off to the individual air guns within the sub-array remotely from the survey vessel.« less

Electrical detection of liquid lithium leaks from pipe joints.

PubMed

Schwartz, J A; Jaworski, M A; Mehl, J; Kaita, R; Mozulay, R

2014-11-01

A test stand for flowing liquid lithium is under construction at Princeton Plasma Physics Laboratory. As liquid lithium reacts with atmospheric gases and water, an electrical interlock system for detecting leaks and safely shutting down the apparatus has been constructed. A defense in depth strategy is taken to minimize the risk and impact of potential leaks. Each demountable joint is diagnosed with a cylindrical copper shell electrically isolated from the loop. By monitoring the electrical resistance between the pipe and the copper shell, a leak of (conductive) liquid lithium can be detected. Any resistance of less than 2 kΩ trips a relay, shutting off power to the heaters and pump. The system has been successfully tested with liquid gallium as a surrogate liquid metal. The circuit features an extensible number of channels to allow for future expansion of the loop. To ease diagnosis of faults, the status of each channel is shown with an analog front panel LED, and monitored and logged digitally by LabVIEW.

International energy indicators

NASA Astrophysics Data System (ADS)

Bauer, E. K.

1980-08-01

Data are compiled in tables and graphs on Iran and Saudi Arabia: crude oil capacity, production, and shut-in, June 1974 to July 1980; OPEC (Ex-Iran and Saudi Arabia); capacity, production, and shut-in, June 1974 to June 1980; non-OPEC Free World and US production of crude oil, January 1973 to May 1980; oil stocks: Free World, US, Japan, and Europe (landed), 1973 - 1st quarter 1980; petroleum consumption by industrial countries, January 1973 to February 1980; USSR crude oil production, January 1974 to July 1980; Free World and US nuclear generation capacity, January 1973 to June 1980; US import of crude oil and products, January 1973 to July 1980; landed cost of Saudi crude in current and 1974 dollars, April 1974 to May 1980; US trade in coal, January 1973 to June 1980; summary of US merchandise trade, 1976 to June 1980; and energy/GNP ratio, 1974-1st quarter 1980. The highlight of each is summarized in the table of contents.

The effect of soft budget constraints on access and quality in hospital care.

PubMed

Shen, Yu-Chu; Eggleston, Karen

2009-06-01

Given an increasingly complex web of financial pressures on providers, studies have examined how hospitals' overall financial health affects different aspects of hospital operations. In our study, we develop an empirical proxy for the concept of soft budget constraint (SBC, Kornai, Kyklos 39:3-30, 1986) as an alternative financial measure of a hospital's overall financial health and offer an initial estimate of the effect of SBCs on hospital access and quality. An organization has a SBC if it can expect to be bailed out rather than shut down. Our conceptual model predicts that hospitals facing softer budget constraints will be associated with less aggressive cost control, and their quality may be better or worse, depending on the scope for damage to quality from noncontractible aspects of cost control. We find that hospitals with softer budget constraints are less likely to shut down safety net services. In addition, hospitals with softer budget constraints appear to have better mortality outcomes for elderly heart attack patients.

Application of Glow Discharge Plasma to Alter Surface Properties of Materials

NASA Technical Reports Server (NTRS)

Trigwell, Steve; Buhler, Charles R.; Calle, Carlos I.

2005-01-01

Some polymer materials that are considered important for spaceport operations are rendered noncompliant when subjected to the Kennedy Space Center (KSC) Standard electrostatic testing. These materials operate in stringent environmental conditions, such as high humidity. Treating materials that fail electrostatic testing and altering their surface properties so that they become compliant would result in considerable cost savings. Significant improvement in electrostatic dissipation of Saf-T-Vu PVC after treatment with air Atmospheric Plasma Glow Discharge (APGD) was observed and the material now passed the KSC electrostatic test. The O:C ratio on the surface, as monitored by X-ray Photoelectron Spectroscopy, increased from 0.165 tO 0.275 indicating enhanced oxidation, and surface contact angle measurements decreased from 107.5 to 72.6 showing increased hydrophilicity that accounted for the increased conductivity. Monitoring of the aging showed that the materials hydrophobic recovery resulted in it failing the electrostatic test 30 hours after treatment. This was probably due to the out-diffusion of the added Zn, Ba, and Cd salt stabilizers detected on the surface and/or diffusion of low molecular weight oligomers. On going work includes improving the long term hydrophilicity by optimizing the APGD process with different gas mixtures. Treatment of other spaceport materials is also presented.

Aviation Security: Efforts to Measure Effectiveness and Address Challenges

DTIC Science & Technology

2003-11-05

AND SUBTITLE AVIATION SECURITY Efforts to Meassure Effectiveness and Address Challenges 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...screeners in becoming more adept at detecting hard -to-spot threat objects. However, TIP was shut down immediately following the September 11

Simple circuit monitors "third wire" in ac lines

NASA Technical Reports Server (NTRS)

Kojima, T. T.; Stuck, D. E.

1980-01-01

Device detects interruption of ground connection in three-wire electrical equipment and shuts off ac power to prevent shock hazard. Silicon-controlled rectifiers detect floating ground, and deenergize optoelectric relays thereby breaking power connections. Circuit could be incorporated into hand tools, appliances, and other electrical equipment.

Pink eye in potato is problematic

USDA-ARS?s Scientific Manuscript database

Fall of 2017 was a challenging harvest season for potato growers in Central Wisconsin because of the less-than-ideal patterns of temperature and precipitation. Late September had several days with high temperatures above 85'F that shut down most harvest operations. Early October brought in quite a f...

46 CFR 34.15-35 - Enclosure openings-T/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS FIREFIGHTING EQUIPMENT Carbon Dioxide... of the carbon dioxide system shall automatically shut down any mechanical ventilation to that space. This will not be required where the carbon dioxide system is a secondary system in addition to another...

BIOLOGICAL EFFECTS OF UTAH VALLEY PARTICLES: A REVIEW

EPA Science Inventory

The Utah Valley provided a unique opportunity to evaluate the health effects of particulate matter (PM) in humans. The area has had intermittently high particle levels with the principal point source being a steel mill. Due to a labor dispute, the mill was shut down. The closu...

46 CFR 34.15-35 - Enclosure openings-T/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS FIREFIGHTING EQUIPMENT Carbon Dioxide... of the carbon dioxide system shall automatically shut down any mechanical ventilation to that space. This will not be required where the carbon dioxide system is a secondary system in addition to another...

46 CFR 34.15-35 - Enclosure openings-T/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS FIREFIGHTING EQUIPMENT Carbon Dioxide... of the carbon dioxide system shall automatically shut down any mechanical ventilation to that space. This will not be required where the carbon dioxide system is a secondary system in addition to another...

46 CFR 34.15-35 - Enclosure openings-T/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS FIREFIGHTING EQUIPMENT Carbon Dioxide... of the carbon dioxide system shall automatically shut down any mechanical ventilation to that space. This will not be required where the carbon dioxide system is a secondary system in addition to another...

Homebound Learning Opportunities: Reaching Out to Older Shut-ins and Their Caregivers.

ERIC Educational Resources Information Center

Penning, Margaret; Wasyliw, Douglas

1992-01-01

Describes Homebound Learning Opportunities, innovative health promotion and educational outreach service for homebound older adults and their caregivers. Notes that program provides over 125 topics for individualized learning programs delivered to participants in homes, audiovisual lending library, educational television programing, and peer…

Specification Guide for Snow Removal Vehicles for Rail Transit Systems

DOT National Transportation Integrated Search

1983-11-01

During the Winter of 1977-1978, a major snow storm shut down the Boston transit system for almost a week and the Winter of 1978-1979 produced similar snow conditions that paraylzed the Chicago transit system and disabled more than half of their rail ...

46 CFR 34.15-35 - Enclosure openings-T/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS FIREFIGHTING EQUIPMENT Carbon Dioxide... of the carbon dioxide system shall automatically shut down any mechanical ventilation to that space. This will not be required where the carbon dioxide system is a secondary system in addition to another...

40 CFR 74.10 - Roles-EPA and permitting authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... allowance allocation, and allocating allowances for combustion or process sources that become affected units under this part; (2) Certifying or recertifying monitoring systems for combustion or process sources as... accounting for the replacement of thermal energy, closing accounts for opt-in sources that shut down, are...

14 CFR 25.1145 - Ignition switches.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 25.1145 Ignition switches. (a) Ignition switches must control each engine ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 29.1145 - Ignition switches.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Powerplant Controls and Accessories § 29.1145 Ignition switches. (a) Ignition switches must control each ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 25.1145 - Ignition switches.

Code of Federal Regulations, 2011 CFR

2011-01-01

... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 25.1145 Ignition switches. (a) Ignition switches must control each engine ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 29.1145 - Ignition switches.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Powerplant Controls and Accessories § 29.1145 Ignition switches. (a) Ignition switches must control each ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 25.1145 - Ignition switches.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 25.1145 Ignition switches. (a) Ignition switches must control each engine ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 29.1145 - Ignition switches.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Powerplant Controls and Accessories § 29.1145 Ignition switches. (a) Ignition switches must control each ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 25.1145 - Ignition switches.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 25.1145 Ignition switches. (a) Ignition switches must control each engine ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 29.1145 - Ignition switches.

Code of Federal Regulations, 2011 CFR

2011-01-01

... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Powerplant Controls and Accessories § 29.1145 Ignition switches. (a) Ignition switches must control each ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 25.1145 - Ignition switches.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Powerplant Controls and Accessories § 25.1145 Ignition switches. (a) Ignition switches must control each engine ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

14 CFR 29.1145 - Ignition switches.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Powerplant Controls and Accessories § 29.1145 Ignition switches. (a) Ignition switches must control each ignition circuit on each engine. (b) There must be means to quickly shut off all ignition by the grouping of switches or by a master ignition control. (c...

Impact of shutting down en route primary radars within CONUS interior

DOT National Transportation Integrated Search

1993-06-01

The Impact on the Air Traffic Control (ATC) operations resulting from the shutdown of alt en route primary radars : (except for ARSR-4s) within the CONUS interior will result in loss of real-time weather data and aircraft skin tracking, : over 33 per...

40 CFR 146.91 - Reporting requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... any event that exceeds operating parameters for annulus pressure or injection pressure specified in the permit; (4) A description of any event which triggers a shut-off device required pursuant to § 146... plugging reports, post-injection site care data, including, if appropriate, data and information used to...

Cost analysis of the Hemodialysis Reliable Outflow (HeRO) Graft compared to the tunneled dialysis catheter.

PubMed

Al Shakarchi, Julien; Inston, Nicholas; Jones, Robert G; Maclaine, Grant; Hollinworth, David

2016-04-01

In end-stage renal disease patients with central venous obstruction, who have limited vascular access options, the Hemodialysis Reliable Outflow (HeRO) Graft is a new alternative with a lower incidence of complications and longer effective device life compared to tunneled dialysis catheters (TDCs). We undertook an economic analysis of introducing the HeRO Graft in the UK. A 1-year cost-consequence decision analytic model was developed comparing management with the HeRO Graft to TDCs from the perspective of the National Health Service in England. The model comprises four 3-month cycles during which the vascular access option either remains functional for hemodialysis or fails, patients can experience access-related infection and device thrombosis, and they can also accrue associated costs. Clinical input data were sourced from published studies and unit cost data from National Health Service 2014-15 Reference Costs. In the base case, a 100-patient cohort managed with the HeRO Graft experienced 6 fewer failed devices, 53 fewer access-related infections, and 67 fewer device thromboses compared to patients managed with TDCs. Although the initial device and placement costs for the HeRO Graft are greater than those for TDCs, savings from the lower incidence of device complications and longer effective device patency reduces these costs. Overall net annual costs are £2600 for each HeRO Graft-managed patient compared to TDC-managed patients. If the National Health Service were to reimburse hemodialysis at a uniform rate regardless of the type of vascular access, net 1-year savings of £1200 per patient are estimated for individuals managed with the HeRO Graft. The base case results showed a marginal net positive cost associated with vascular access with the HeRO Graft compared with TDCs for the incremental clinical benefit of reductions in patency failures, device-related thrombosis, and access-related infection events in a patient population with limited options for dialysis vascular access. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Promoting health and reducing costs: a role for reform of self-monitoring of blood glucose provision within the National Health Service.

PubMed

Leigh, S; Idris, I; Collins, B; Granby, P; Noble, M; Parker, M

2016-05-01

To determine the cost-effectiveness of all options for the self-monitoring of blood glucose funded by the National Health Service, providing guidance for disinvestment and testing the hypothesis that advanced meter features may justify higher prices. Using data from the Health and Social Care Information Centre concerning all 8 340 700 self-monitoring of blood glucose-related prescriptions during 2013/2014, we conducted a cost-minimization analysis, considering both strip and lancet costs, including all clinically equivalent technologies for self-monitoring of blood glucose, as determined by the ability to meet ISO-15197:2013 guidelines for meter accuracy. A total of 56 glucose monitor, test strip and lancet combinations were identified, of which 38 met the required accuracy standards. Of these, the mean (range) net ingredient costs for test strips and lancets were £0.27 (£0.14-£0.32) and £0.04 (£0.02-£0.05), respectively, resulting in a weighted average of £0.28 (£0.18-£0.37) per test. Systems providing four or more advanced features were priced equal to those providing just one feature. A total of £12 m was invested in providing 42 million self-monitoring of blood glucose tests with systems that fail to meet acceptable accuracy standards, and efficiency savings of £23.2 m per annum are achievable if the National Health Service were to disinvest from technologies providing lesser functionality than available alternatives, but at a much higher price. The study uncovered considerable variation in the price paid by the National Health Service for self-monitoring of blood glucose, which could not be explained by the availability of advanced meter features. A standardized approach to self-monitoring of blood glucose prescribing could achieve significant efficiency savings for the National Health Service, whilst increasing overall utilisation and improving safety for those currently using systems that fail to meet acceptable standards for measurement accuracy. © 2015 Diabetes UK.

Properties of single NMDA receptor channels in human dentate gyrus granule cells

PubMed Central

Lieberman, David N; Mody, Istvan

1999-01-01

Cell-attached single-channel recordings of NMDA channels were carried out in human dentate gyrus granule cells acutely dissociated from slices prepared from hippocampi surgically removed for the treatment of temporal lobe epilepsy (TLE). The channels were activated by l-aspartate (250–500 nm) in the presence of saturating glycine (8 μm). The main conductance was 51 ± 3 pS. In ten of thirty granule cells, clear subconductance states were observed with a mean conductance of 42 ± 3 pS, representing 8 ± 2% of the total openings. The mean open times varied from cell to cell, possibly owing to differences in the epileptogenicity of the tissue of origin. The mean open time was 2.70 ± 0.95 ms (range, 1.24–4.78 ms). In 87% of the cells, three exponential components were required to fit the apparent open time distributions. In the remaining neurons, as in control rat granule cells, two exponentials were sufficient. Shut time distributions were fitted by five exponential components. The average numbers of openings in bursts (1.74 ± 0.09) and clusters (3.06 ± 0.26) were similar to values obtained in rodents. The mean burst (6.66 ± 0.9 ms), cluster (20.1 ± 3.3 ms) and supercluster lengths (116.7 ± 17.5 ms) were longer than those in control rat granule cells, but approached the values previously reported for TLE (kindled) rats. As in rat NMDA channels, adjacent open and shut intervals appeared to be inversely related to each other, but it was only the relative areas of the three open time constants that changed with adjacent shut time intervals. The long openings of human TLE NMDA channels resembled those produced by calcineurin inhibitors in control rat granule cells. Yet the calcineurin inhibitor FK-506 (500 nm) did not prolong the openings of human channels, consistent with a decreased calcineurin activity in human TLE. Many properties of the human NMDA channels resemble those recorded in rat hippocampal neurons. Both have similar slope conductances, five exponential shut time distributions, complex groupings of openings, and a comparable number of openings per grouping. Other properties of human TLE NMDA channels correspond to those observed in kindling; the openings are considerably long, requiring an additional exponential component to fit their distributions, and inhibition of calcineurin is without effect in prolonging the openings. PMID:10373689

Risk factor assessment to anticipate performance in the National Developmental Screening Test in children from a disadvantaged area.

PubMed

Montes, Alejandro; Pazos, Gustavo

2016-02-01

Identifying children at risk of failing the National Developmental Screening Test by combining prevalences of children suspected of having inapparent developmental disorders (IDDs) and associated risk factors (RFs) would allow to save resources. 1. To estimate the prevalence of children suspected of having IDDs. 2. To identify associated RFs. 3. To assess three methods developed based on observed RFs and propose a pre-screening procedure. The National Developmental Screening Test was administered to 60 randomly selected children aged between 2 and 4 years old from a socioeconomically disadvantaged area from Puerto Madryn. Twenty-four biological and socioenvironmental outcome measures were assessed in order to identify potential RFs using bivariate and multivariate analyses. The likelihood of failing the screening test was estimated as follows: 1. a multivariate logistic regression model was developed; 2. a relationship was established between the number of RFs present in each child and the percentage of children who failed the test; 3. these two methods were combined. The prevalence of children suspected of having IDDs was 55.0% (95% confidence interval: 42.4%-67.6%). Six RFs were initially identified using the bivariate approach. Three of them (maternal education, number of health checkups and Z scores for height-for-age, and maternal age) were included in the logistic regression model, which has a greater explanatory power. The third method included in the assessment showed greater sensitivity and specificity (85% and 79%, respectively). The estimated prevalence of children suspected of having IDDs was four times higher than the national standards. Seven RFs were identified. Combining the analysis of risk factor accumulation and a multivariate model provides a firm basis for developing a sensitive, specific and practical pre-screening procedure for socioeconomically disadvantaged areas. Sociedad Argentina de Pediatría.

Evaluating the use of plerixafor in stem cell mobilisation - an economic analysis of the PHANTASTIC trial.

PubMed

Martin, Antony P; Richards, Sarah; Haycox, Alan; Houten, Rachel; McLeod, Claire; Braithwaite, Barbara; Clark, Jack O; Bell, Joanne; Clark, Richard E

2016-10-01

Plerixafor is an effective haematopoietic stem cell mobilising agent in candidates for autologous transplantation, including patients with myeloma and lymphoma. Here we compare 98 plerixafor recipients in the PHANTASTIC trial with 151 historic controls mobilised by conventional chemotherapy (each with granulocyte colony-stimulating factor, G-CSF). Seventy (71.4%) plerixafor-mobilised patients achieved the composite primary endpoint of ≥4 × 10(6) CD34+ cells kg(-1) in ≤2 aphereses and no clinically significant neutropenia, compared to 48 (31.8%) historic controls (P < 0.001), and this significant advantage was maintained in scenario analyses testing components of this composite endpoint. A patient-level cost analysis was undertaken for 249 patients, which included the cost of remobilising patients where initial mobilisation had failed. Combined mean treatment cost for plerixafor mobilised patients was £12,679 compared with £11,694 for historical controls. However, plerixafor produces an average saving of £3,828 per lymphoma patient but average cost increase by £5,245 per myeloma patient. The present data demonstrate cost-effectiveness for plerixafor as a first line mobilisation agent, certainly for lymphoma patients, where substantial resource savings and achievement of the primary endpoint are likely. J. Clin. Apheresis 31:434-442, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Cost-effectiveness of lumbar artificial intervertebral disc replacement: driven by the choice of comparator.

PubMed

Parkinson, Bonny; Goodall, Stephen; Thavaneswaran, Prema

2013-09-01

Lower back pain is a common and costly condition in Australia. This paper aims to conduct an economic evaluation of lumbar artificial intervertebral disc replacement (AIDR) compared with lumbar fusion for the treatment of patients suffering from significant axial back pain and/or radicular (nerve root) pain, secondary to disc degeneration or prolapse, who have failed conservative treatment. A cost-effectiveness approach was used to compare costs and benefits of AIDR to five fusion approaches. Resource use was based on Medicare Benefits Schedule claims data and expert opinion. Effectiveness and re-operation rates were based on published randomized controlled trials. The key clinical outcomes considered were narcotic medication discontinuation, achievement of overall clinical success, achievement of Oswestry Disability Index success and quality-adjusted life-years gained. AIDR was estimated to be cost-saving compared with fusion overall ($1600/patient); however, anterior lumbar interbody fusion and posterolateral fusion were less costly by $2155 and $807, respectively. The incremental cost-effectiveness depends on the outcome considered and the comparator. AIDR is potentially a cost-saving treatment for lumbar disc degeneration, although longer-term follow-up data are required to substantiate this claim. The incremental cost-effectiveness depends on the outcome considered and the comparator, and further research is required before any firm conclusions can be drawn. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

Thin spray film thickness measuring technique

NASA Technical Reports Server (NTRS)

Jones, G.; Kurtz, G. W.

1971-01-01

Thin spray film application depths, in the 0.0002 cm to 0.002 cm range, are measured by portable, commercially available, light density measuring device used in conjunction with glass plate or photographic film. Method is automated by using mechanical/electrical control for shutting off film applicator at desired densitometer reading.

Qualitative Approaches to Mixed Methods Practice

ERIC Educational Resources Information Center

Hesse-Biber, Sharlene

2010-01-01

This article discusses how methodological practices can shape and limit how mixed methods is practiced and makes visible the current methodological assumptions embedded in mixed methods practice that can shut down a range of social inquiry. The article argues that there is a "methodological orthodoxy" in how mixed methods is practiced…

When Missions Collide: Theological Certainty and Democratic Education

ERIC Educational Resources Information Center

James, Jennifer Hauver

2011-01-01

Teacher education should provide opportunities for preservice teachers to think about the intersection of their faith and their practice. Students with a high degree of theological certainty may shut down those conversations and therefore deny themselves and their classmates opportunities to wrestle with questions related to their religious…

A rapid biochemical test to assess postharvest deterioration of sugarcane and milled juice

USDA-ARS?s Scientific Manuscript database

The delivery of consignments of deteriorated sugarcane to factories can detrimentally affect multiple process units, and even lead to a factory shut-down. An enzymatic factory method was used to measure mannitol, a major degradation product of sugarcane Leuconostoc deterioration in the U.S., in pre...

Survive or Thrive?

ERIC Educational Resources Information Center

Hu, Helen

2011-01-01

With local lumber mills shutting down, Robert Kenning, an instructor at Salish Kootenai College in western Montana, and the tribe's forestry director, came up with an idea. Kenning landed a $200,000 Department of Agriculture grant in 2010 to explore the possibility of turning logging scraps and smaller trees into chips or pellets that could be…

46 CFR 112.50-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... degrees C). (c) The room that has the generator set must have intake and exhaust ducts to supply adequate... thermostatically-controlled electric water-jacket heater connected to the final emergency bus is permitted. (e) The... generator set must shut down automatically upon loss of lubricating oil pressure, overspeed, or operation of...

Shut Out

ERIC Educational Resources Information Center

Roach, Ronald

2009-01-01

As director of the Lawyering in the Digital Age Clinic at the Columbia University Law School, law professor Conrad Johnson knows that digital technology has the power to highlight and amplify social justice concerns and to enable people to take direct action. Under Johnson's leadership, the clinic has developed and maintained the Columbia-hosted…

The Locker Problem: An Open and Shut Case

ERIC Educational Resources Information Center

Kimani, Patrick M.; Olanoff, Dana; Masingila, Joanna O.

2016-01-01

This article discusses how teaching via problem solving helps enact the Mathematics Teaching Practices and supports students' learning and development of the Standards for Mathematical Practice. This approach involves selecting and implementing mathematical tasks that serve as vehicles for meeting the learning goals for the lesson. For the lesson…

Magnetic bearings for a high-performance optical disk buffer, volume 2

NASA Technical Reports Server (NTRS)

1990-01-01

The operating instructions for the magnetic bearings of a high-performance optical disk buffer are provided. Among the topics that are discussed are the following: front panel layout, turn-on procedure, shut-down procedure, and latch-up protection. Additionally, comprehensive engineering drawings are presented for the design.

Laying the Groundwork

ERIC Educational Resources Information Center

Cooper, Kenneth J.

2010-01-01

Only a few of Haiti's colleges have resumed classes since the earthquake effectively shut down higher education in the impoverished country. Most of the country's 159 colleges are concentrated in the devastated capital of Port-au-Prince. Those that have reopened are housed in temporary quarters. The destruction of Haitian higher education was so…

Death by Numbers: A Response to Backer, Sarigianides, and Stillwaggon

ERIC Educational Resources Information Center

Taubman, Peter

2017-01-01

In this response essay, Peter Taubman considers the relationship between melancholia and Freud's notion of a death drive. Taubman explores how audit culture sustains melancholia and intensifies the death drive, ultimately deadening our psyches by erasing memory, disparaging feelings, shutting down thought, and ignoring history. Taubman concludes…

"Every Shut Eye Ain't Sleep": Studying How People Live Culturally.

ERIC Educational Resources Information Center

Lee, Carol D.; Spencer, Margaret Beale; Harpalani, Vinay

2003-01-01

Recommends the integration of cultural socialization and identity processes in learning within educational research in order to improve educational outcomes for racial/ethnic minorities and youth facing persistent intergenerational poverty. Suggests that educational researchers must understand the cultural niches in which young people develop,…

Academic Bullies

ERIC Educational Resources Information Center

Fogg, Piper

2008-01-01

Many professors have been traumatized by academic bullies. Unlike bullies at school, the academic bully plays a more subtle game. Bullies may spread rumors to undermine a colleague's credibility or shut their target out of social conversations. The more aggressive of the species cuss out co-workers, even threatening to get physical. There is…

30 CFR 27.24 - Power-shutoff component.

Code of Federal Regulations, 2010 CFR

2010-07-01

... APPROVAL OF MINING PRODUCTS METHANE-MONITORING SYSTEMS Construction and Design Requirements § 27.24 Power... the machine or equipment when actuated by the methane detector at a methane concentration of 2.0... actuated by the methane detector, cause a control circuit to shut down the machine or equipment on which it...

Shutting Out Child-Snatchers.

ERIC Educational Resources Information Center

Trotter, Andrew

1993-01-01

Parental kidnapping could lead to a lawsuit against the school or principal. After general building security, schools need to check on custody status, network with the courts, and convince both custodial and noncustodial parents that schools are on the children's side. A summary provides 14 steps to safeguard against parental kidnapping. (MLF)

Cost, weight and lead time impacts of a Mercedes-Benz 'Sensormat' type occupant detection system

DOT National Transportation Integrated Search

1997-04-19

This summary report is based, in part, on the findings contained in Contract No. DTNH22-96-C-02063 entitled "Cost Analysis of the Mercedes-Benz Occupant Detection System for Air Bag Shut-Off" prepared by Ludtke and Associates of Washington, Michigan....

14 CFR 23.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flammable fluid fire protection. 23.863... Construction Fire Protection § 23.863 Flammable fluid fire protection. (a) In each area where flammable fluids... fluids, shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of...

14 CFR 29.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Flammable fluid fire protection. 29.863... § 29.863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might..., shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft...

14 CFR 29.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Flammable fluid fire protection. 29.863... § 29.863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might..., shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft...

14 CFR 29.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flammable fluid fire protection. 29.863... § 29.863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might..., shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft...

14 CFR 23.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Flammable fluid fire protection. 23.863... Construction Fire Protection § 23.863 Flammable fluid fire protection. (a) In each area where flammable fluids... fluids, shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of...

14 CFR 23.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flammable fluid fire protection. 23.863... Construction Fire Protection § 23.863 Flammable fluid fire protection. (a) In each area where flammable fluids... fluids, shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of...

14 CFR 29.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flammable fluid fire protection. 29.863... § 29.863 Flammable fluid fire protection. (a) In each area where flammable fluids or vapors might..., shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of rotorcraft...

14 CFR 23.863 - Flammable fluid fire protection.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Flammable fluid fire protection. 23.863... Construction Fire Protection § 23.863 Flammable fluid fire protection. (a) In each area where flammable fluids... fluids, shutting down equipment, fireproof containment, or use of extinguishing agents. (5) Ability of...

29 CFR 1910.266 - Logging operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... employee against contact with a running chain saw. Sharp, calk-soled boots or other slip-resistant type... (C) Each moving element such as, but not limited to blades, buckets, saws and shears, shall be... moving elements such as, but not limited to, blades, buckets, saws and shears, after the machine is shut...

29 CFR 1910.266 - Logging operations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... employee against contact with a running chain saw. Sharp, calk-soled boots or other slip-resistant type... (C) Each moving element such as, but not limited to blades, buckets, saws and shears, shall be... moving elements such as, but not limited to, blades, buckets, saws and shears, after the machine is shut...

29 CFR 1910.266 - Logging operations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... employee against contact with a running chain saw. Sharp, calk-soled boots or other slip-resistant type... (C) Each moving element such as, but not limited to blades, buckets, saws and shears, shall be... moving elements such as, but not limited to, blades, buckets, saws and shears, after the machine is shut...

29 CFR 1910.266 - Logging operations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... employee against contact with a running chain saw. Sharp, calk-soled boots or other slip-resistant type... (C) Each moving element such as, but not limited to blades, buckets, saws and shears, shall be... moving elements such as, but not limited to, blades, buckets, saws and shears, after the machine is shut...

29 CFR 1910.266 - Logging operations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... employee against contact with a running chain saw. Sharp, calk-soled boots or other slip-resistant type... (C) Each moving element such as, but not limited to blades, buckets, saws and shears, shall be... moving elements such as, but not limited to, blades, buckets, saws and shears, after the machine is shut...

News and Views.

ERIC Educational Resources Information Center

Journal of Blacks in Higher Education, 2003

2003-01-01

This collection of articles focuses such issues as the number of blacks completing doctoral degrees; the steady march of blacks into higher education; racial desensitization of the American public; the impact of Condoleezza Rice's statement on race-conscious admissions; how higher education shuts the door on the racial poverty gap; and how a…

76 FR 8281 - Amendment to Class B Airspace; Cleveland, OH

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... submissions, including comments from Aircraft Owners and Pilots Association (AOPA) and the Soaring Society of... B airspace directly over the airspace Fun Country Soaring (FCS) currently flies in and would... indicated that a soaring club would be forced to consider shutting down or relocating operations as a result...

40 CFR 57.304 - Bypass, excess emissions and malfunctions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... malfunctions. 57.304 Section 57.304 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... limitation, as well as the operating data, documents, and calculations used in determining the magnitude of... malfunction (or an unavoidable start up and shut down resulting from a malfunction) and that: (1) The air...

40 CFR 57.304 - Bypass, excess emissions and malfunctions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... malfunctions. 57.304 Section 57.304 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... limitation, as well as the operating data, documents, and calculations used in determining the magnitude of... malfunction (or an unavoidable start up and shut down resulting from a malfunction) and that: (1) The air...

40 CFR 57.304 - Bypass, excess emissions and malfunctions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... malfunctions. 57.304 Section 57.304 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... limitation, as well as the operating data, documents, and calculations used in determining the magnitude of... malfunction (or an unavoidable start up and shut down resulting from a malfunction) and that: (1) The air...

40 CFR 57.304 - Bypass, excess emissions and malfunctions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... malfunctions. 57.304 Section 57.304 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... limitation, as well as the operating data, documents, and calculations used in determining the magnitude of... malfunction (or an unavoidable start up and shut down resulting from a malfunction) and that: (1) The air...

40 CFR 57.304 - Bypass, excess emissions and malfunctions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... malfunctions. 57.304 Section 57.304 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... limitation, as well as the operating data, documents, and calculations used in determining the magnitude of... malfunction (or an unavoidable start up and shut down resulting from a malfunction) and that: (1) The air...

77 FR 29861 - Airworthiness Directives; Fokker Services B.V. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... an in-flight failure of the hydraulic control panel, which resulted in the absence of pressure and... absence of pressure and quantity indication of the hydraulic system and accompanying alerts for... shut-off of the engine driven hydraulic pumps, resulting in complete absence of hydraulic pressure...

75 FR 61655 - Airworthiness Directives; Piper Aircraft, Inc. Model PA-28-161 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... (FADEC) backup battery, replacing the supplement pilot's operating handbook and FAA approved airplane... can allow the FADEC to shut down or reset if the main battery is depleted and the electrical charging... service information describes procedures for installation of a FADEC backup battery. FAA's Determination...

40 CFR 1065.526 - Repeating void modes or test intervals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... or test intervals in any circumstances that would be inconsistent with good engineering judgment. For... that include hybrid energy storage features or emission controls that involve physical or chemical... shut down, restart the engine. (2) Use good engineering judgment to restart the test sequence using the...

40 CFR 1065.526 - Repeating of void modes or test intervals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... or test intervals in any circumstances that would be inconsistent with good engineering judgment. For... that include hybrid energy storage features or emission controls that involve physical or chemical... follows: (1) If the engine has stalled or been shut down, restart the engine. (2) Use good engineering...

40 CFR 1065.526 - Repeating void modes or test intervals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... or test intervals in any circumstances that would be inconsistent with good engineering judgment. For... that include hybrid energy storage features or emission controls that involve physical or chemical... shut down, restart the engine. (2) Use good engineering judgment to restart the test sequence using the...

9 CFR 307.7 - Safety requirements for electrical stimulating (EST) equipment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... beam sensors form the enclosure, the stimulating equipment shall be automatically shut off when the sensor signals are broken. (3) Mandatory Warning Devices and Signals. The following warning devices or.... (ii) An ANSI Z53.1-Color Code sign reading (a) “Danger Electrical Hazard” for stimulating voltage...

9 CFR 307.7 - Safety requirements for electrical stimulating (EST) equipment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... beam sensors form the enclosure, the stimulating equipment shall be automatically shut off when the sensor signals are broken. (3) Mandatory Warning Devices and Signals. The following warning devices or.... (ii) An ANSI Z53.1-Color Code sign reading (a) “Danger Electrical Hazard” for stimulating voltage...

Back-pressure Effect on Shock-Train Location in a Scramjet Engine Isolator

DTIC Science & Technology

2010-03-01

valves .......................................................................................... 57 Side project: making an actuator stand...21 Figure 8. Main manual shut off valve ...................................................................................22 Figure 9 . A small...characteristic about this wind tunnel. With Mach 1.8 nozzle, prior to test runs, the upstream regulator pressure valve (Figure 9 ) was set at

46 CFR 153.296 - Emergency shutdown stations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... shutdown station must contain a single remote actuator for all quick closing shutoff valves required by... on the tankship. (f) Any remote emergency actuator, such as that for a quick closing shut-off valve... remote emergency actuators. The emergency action must occur whether one or several actuators are operated...

Prenatally stressed piglets 'shut down' in response to separation, oxytocin modulates some effects

USDA-ARS?s Scientific Manuscript database

Prenatal stress (PNS) effects may enhance offspring’s survival traits. Yet, PNS could be maladaptive for captive animals, causing anxiety and abnormal social development. Oxytocin (OT) reduces anxiety while OT deficiency results in social behavior alteration. We hypothesized that PNS piglets would b...

Structure of Child and Adult Past Counterfactuals, and Implications for Acquisition of the Construction

ERIC Educational Resources Information Center

Crutchley, Alison

2013-01-01

Children start producing ["necessary and sufficient"] conditionals relatively late. Past counterfactuals (PCFs), for example "If she had shut the cage, the rabbit wouldn't have escaped", are particularly problematic for children; despite evidence of comprehension in the preschool years, children aged eleven are still making…

East Europe Report.

DTIC Science & Technology

1986-09-06

merchandising, and services. Thus, Po- land is showing interest in the construction of a network of hotels in the country, through cooperation between...screamers. How is it that they eanr more in one day than an engineer gets in three months? 95 Shut down the boutiques . Who needs blouses for 15t000

17. ROSS POWERHOUSE: BUTTERFLY VALVE CONTROLS FOR UNIT 43. THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. ROSS POWERHOUSE: BUTTERFLY VALVE CONTROLS FOR UNIT 43. THE BUTTERFLY VALVE LOCK INDICATES THE BUTTERFLY VALVE IS CLOSED AS UNIT 43 WAS SHUT DOWN FOR REPAIRS, 1989. - Skagit Power Development, Ross Powerhouse, On Skagit River, 10.7 miles upstream from Newhalem, Newhalem, Whatcom County, WA

View of water wheel, generator #3 and exciter (at east ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of water wheel, generator #3 and exciter (at east end of Childs Powerhouse) on a single shaft. In foreground the governor and shut-off valve are visible. Looking southwest - Childs-Irving Hydroelectric Project, Childs System, Childs Powerhouse, Forest Service Road 708/502, Camp Verde, Yavapai County, AZ

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2013 CFR

2013-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2012 CFR

2012-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2011 CFR

2011-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

46 CFR 98.25-40 - Valves, fittings, and accessories.

Code of Federal Regulations, 2014 CFR

2014-10-01

... located at the highest practical point. The thermometer well shall terminate in the liquid space and be... and discharge liquid and vapor shut-off valves, safety relief valves, liquid level gaging devices... to the tanks, except safety devices and liquid level gaging devices, shall have manually operated...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2010 CFR

2010-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2011 CFR

2011-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

40 CFR 281.33 - Release detection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... equipped with release detection that detects a release within an hour by restricting or shutting off flow... designed to allow the contents of the pipe to drain back into the storage tank if the suction is released... UST systems must use interstitial monitoring within secondary containment of the tanks and the...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2012 CFR

2012-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

40 CFR 281.33 - Release detection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... equipped with release detection that detects a release within an hour by restricting or shutting off flow... designed to allow the contents of the pipe to drain back into the storage tank if the suction is released... UST systems must use interstitial monitoring within secondary containment of the tanks and the...

40 CFR 281.33 - Release detection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... equipped with release detection that detects a release within an hour by restricting or shutting off flow... designed to allow the contents of the pipe to drain back into the storage tank if the suction is released... UST systems must use interstitial monitoring within secondary containment of the tanks and the...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2013 CFR

2013-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2014 CFR

2014-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

Impact of Shutting Down En Route Primary Radars within CONUS Interior

DTIC Science & Technology

1993-06-01

Remote Control Interface Unit ( RCIU ) RMS software for the primary radar will be deleted. Any dependency of the secondary radar on the primary radar data...Generators RCIU Remote Control and Interface Unit RMM Remote Monitoring and Maintenance RMMS Remote Maintenance Monitoring System RMS Remote Maintenance

46 CFR 132.330 - Fire monitors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire monitors. 132.330 Section 132.330 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS FIRE-PROTECTION EQUIPMENT Miscellaneous § 132.330 Fire monitors. (a) Each fire monitor of the fire main system must be fitted with a shut...

30 CFR 27.24 - Power-shutoff component.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the machine or equipment when actuated by the methane detector at a methane concentration of 2.0... actuated by the methane detector, cause a control circuit to shut down the machine or equipment on which it...-shutoff component shall, when actuated by the methane detector, cause a control circuit to deenergize the...

30 CFR 27.24 - Power-shutoff component.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the machine or equipment when actuated by the methane detector at a methane concentration of 2.0... actuated by the methane detector, cause a control circuit to shut down the machine or equipment on which it...-shutoff component shall, when actuated by the methane detector, cause a control circuit to deenergize the...

30 CFR 27.24 - Power-shutoff component.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the machine or equipment when actuated by the methane detector at a methane concentration of 2.0... actuated by the methane detector, cause a control circuit to shut down the machine or equipment on which it...-shutoff component shall, when actuated by the methane detector, cause a control circuit to deenergize the...

30 CFR 27.24 - Power-shutoff component.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the machine or equipment when actuated by the methane detector at a methane concentration of 2.0... actuated by the methane detector, cause a control circuit to shut down the machine or equipment on which it...-shutoff component shall, when actuated by the methane detector, cause a control circuit to deenergize the...

Solid-state power controller

NASA Technical Reports Server (NTRS)

Fox, D. A.; Fullemann, J. S.

1980-01-01

Compact, solid state, electric-power controller switches power on and off at remote load, limits current drawn by load, and shuts off (with 2- to 3- second trip time) in case of short circuit. Lightweight efficient hybrid unit operates at 28 volts dc and at maximum currents of from 3 to 2 amperes.

Mouths Wide Shut: Gender-Quiet Teenage Males on Gender-Bending, Gender-Passing and Masculinities

ERIC Educational Resources Information Center

Davidson, Samuel M.

2009-01-01

Through individual narratives, three adolescent males of colour reflect on their fluid masculinities in relation to ethnicity, spirituality and sexuality. The self-described gender benders examine their complex relationships and hybrid identities, which cross the various boundaries of heteronormativity routinely legitimatised through peer norms…

DOE Office of Scientific and Technical Information (OSTI.GOV)

BEHAR, Christophe; GUIBERTEAU, Philippe; DUPERRET, Bernard

This paper describes the D&D program that is being implemented at France's High Enrichment Gaseous Diffusion Plant, which was designed to supply France's Military with Highly Enriched Uranium. This plant was definitively shut down in June 1996, following French President Jacques Chirac's decision to end production of Highly Enriched Uranium and dismantle the corresponding facilities.

Conversation Interrupted

ERIC Educational Resources Information Center

Mayfield, Vernita

2016-01-01

The author, a consultant on school equity, describes a common situation: teachers try to discuss the issue of inequitable outcomes for students of color, and all of a sudden, the conversation stalls. Such discussions are not the norm for educators. They often shut down or disengage emotionally because of various fears. When schools realize that…

30 CFR 36.23 - Engine intake system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Engine intake system. 36.23 Section 36.23... EQUIPMENT Construction and Design Requirements § 36.23 Engine intake system. (a) Construction. The intake... operator's compartment, to shut off the air supply to the engine. This valve shall be constructed to permit...

30 CFR 36.23 - Engine intake system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Engine intake system. 36.23 Section 36.23... EQUIPMENT Construction and Design Requirements § 36.23 Engine intake system. (a) Construction. The intake... operator's compartment, to shut off the air supply to the engine. This valve shall be constructed to permit...

Chronicle of Higher Education. Volume 51, Number 13, November 19, 2004

ERIC Educational Resources Information Center

Chronicle of Higher Education, 2004

2004-01-01

"Chronicle of Higher Education" presents an abundant source of news and information for college and university faculty members and administrators. This November 19, 2004 issue of "Chronicle for Higher Education" includes the following articles: (1) "Mr. Water" (Zaragoza); (2) "Philippine Government Shuts Down 23…

33 CFR 155.750 - Contents of transfer procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Monitor the level of cargo in the tank; and (ii) Shut down transfer operations in time to ensure that the... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Contents of transfer procedures... (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Transfer...

Somalia: Current Conditions and Prospects for a Lasting Peace

DTIC Science & Technology

2011-04-20

hijacked. In 2009, the Ukrainian-owned ship, MV Faina, which was carrying 33 T-72 tanks and other weapons and a Japanese -owned ship, MV Chemstar, were...characterized as extremist and jihadist. The ICU was accused of shutting down cinemas and prohibiting women from working. Some of these measures were

Somalia: Current Conditions and Prospects for a Lasting Peace

DTIC Science & Technology

2010-02-04

weapons and a Japanese -owned ship, MV Chemstar, were released. The pirates have reportedly earned more than $120 million in ransom payments, and have...shutting down cinemas and prohibiting women from working. Some of these measures were taken by the Courts, although for different reasons and not because

Somalia: Current Conditions and Prospects for a Lasting Peace

DTIC Science & Technology

2010-08-06

Ukrainian-owned ship, MV Faina, which was carrying 33 T-72 tanks and other weapons and a Japanese -owned ship, MV Chemstar, were released. In February...and jihadist. The ICU was accused of shutting down cinemas and prohibiting women from working. Some of these measures were taken by the Courts

Somalia: Current Conditions and Prospects for a Lasting Peace

DTIC Science & Technology

2009-05-21

February 2009, Somali pirates released several ships, including a Japanese -owned ship, MV Chemstar, and the MV Faina. The pirates have reportedly earned...extremist and jihadist. The ICU was accused of shutting down cinemas and prohibiting women from working. Some of these measures were taken by the Courts

49 CFR 192.605 - Procedural manual for operations, maintenance, and emergencies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... maintenance activities and for emergency response. For transmission lines, the manual must also include... and effective manner. (5) Starting up and shutting down any part of the pipeline in a manner designed... control room management procedures required by § 192.631. (c) Abnormal operation. For transmission lines...

47 CFR 20.21 - Signal boosters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... operation to ensure compliance with applicable noise and gain limits and either self-correct or shut down... provide equivalent uplink and downlink gain and conducted uplink power output that is at least 0.05 watts... referenced to the booster's input port for each band of operation. (C) Booster Gain Limits. (1) The uplink...

47 CFR 20.21 - Signal boosters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... operation to ensure compliance with applicable noise and gain limits and either self-correct or shut down... provide equivalent uplink and downlink gain and conducted uplink power output that is at least 0.05 watts... referenced to the booster's input port for each band of operation. (C) Booster Gain Limits. (1) The uplink...

46 CFR 111.12-11 - Generator protection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Generator protection. 111.12-11 Section 111.12-11...-GENERAL REQUIREMENTS Generator Construction and Circuits § 111.12-11 Generator protection. (a... shutting down of the prime mover; (2) Have longtime overcurrent trips or relays set as necessary to...

46 CFR 111.12-11 - Generator protection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Generator protection. 111.12-11 Section 111.12-11...-GENERAL REQUIREMENTS Generator Construction and Circuits § 111.12-11 Generator protection. (a... shutting down of the prime mover; (2) Have longtime overcurrent trips or relays set as necessary to...

14 CFR 29.1189 - Shutoff means.

Code of Federal Regulations, 2010 CFR

2010-01-01

... engine; (2) For oil systems for turbine engine installations in which all components of the system, including oil tanks, are fireproof or located in areas not subject to engine fire conditions; or (3) For...) There must be means to shut off or otherwise prevent hazardous quantities of fuel, oil, de-icing fluid...

School Library Renaissance in Baltimore County: An Open-and-Shut Case for Library Funding.

ERIC Educational Resources Information Center

Curtis, Della

2000-01-01

Explains how Baltimore County secondary school libraries increased their funding and staffing levels. Discusses a partnership with Towson University for staffing needs; the role of technology; the development of online learning modules; marketing efforts; state standards for library collections; and collection analysis criteria. (LRW)

Can neutrino decay-driven mock gravity save hot dark matter?

NASA Technical Reports Server (NTRS)

Splinter, Randall J.; Melott, Adrian L.

1992-01-01

The radiative decay of a 30 eV neutrino with a lifetime of order 10 exp 23-24 s has recently been shown to yield a satisfactory explanation of a wide range of problems in astrophysics. In this paper, it is investigated whether the photon flux generated by the radiative decay of a massive neutrino is capable of generating sufficient radiation pressure to cause a 'mock gravitational' collapse of primordial hydrogen clouds. It is shown that when using neutral hydrogen as a source of opacity for mock gravity the time scale for mock gravitational collapse is significantly larger than the expansion time scale. Thus, the model fails as a source of galactic seed perturbations. Furthermore, it is argued that nonlinear feedback mechanisms will be unable to increase the collapse rate of the cloud under mock gravity.

Rabbits killing birds revisited.

PubMed

Zhang, Jimin; Fan, Meng; Kuang, Yang

2006-09-01

We formulate and study a three-species population model consisting of an endemic prey (bird), an alien prey (rabbit) and an alien predator (cat). Our model overcomes several model construction problems in existing models. Moreover, our model generates richer, more reasonable and realistic dynamics. We explore the possible control strategies to save or restore the bird by controlling or eliminating the rabbit or the cat when the bird is endangered. We confirm the existence of the hyperpredation phenomenon, which is a big potential threat to most endemic prey. Specifically, we show that, in an endemic prey-alien prey-alien predator system, eradication of introduced predators such as the cat alone is not always the best solution to protect endemic insular prey since predator control may fail to protect the indigenous prey when the control of the introduced prey is not carried out simultaneously.

Using informed consent to save trust.

PubMed

Eyal, Nir

2014-07-01

Increasingly, bioethicists defend informed consent as a safeguard for trust in caretakers and medical institutions.This paper discusses an ‘ideal type’ of that move. What I call the trust-promotion argument for informed consent states:1. Social trust, especially trust in caretakers and medical institutions, is necessary so that, for example,people seek medical advice, comply with it, and participate in medical research.2. Therefore, it is usually wrong to jeopardise that trust.3. Coercion, deception, manipulation and other violations of standard informed consent requirements seriously jeopardise that trust.4. Thus, standard informed consent requirements are justified.This article describes the initial promise of this argument, then identifies challenges to it. As I show, the value of trust fails to account for some common sense intuitions about informed consent. We should revise the argument, common sense morality, or both.

Thrombolytic Therapy by Tissue Plasminogen Activator for Pulmonary Embolism.

PubMed

Islam, Md Shahidul

2017-01-01

Clinicians need to make decisions about the use of thrombolytic (fibrinolytic) therapy for pulmonary embolism (PE) after carefully considering the risks of major complications from bleeding, and the benefits of treatment, for each individual patient. They should probably not use systemic thrombolysis for PE patients with normal blood pressure. Treatment by human recombinant tissue plasminogen activator (rt-PA), alteplase, saves the lives of high-risk PE patients, that is, those with hypotension or in shock. Even in the absence of strong evidence, clinicians need to choose the most appropriate regimen for administering alteplase for individual patients, based on assessment of the urgency of the situation, risks for major complications from bleeding, and patient's body weight. In addition, invasive strategies should be considered when absolute contraindications for thrombolytic therapy exist, serious complications arise, or thrombolytic therapy fails.

ECMO support for right main bronchial disruption in multiple trauma patient with brain injury--a case report and literature review.

PubMed

Zhou, R; Liu, B; Lin, K; Wang, R; Qin, Z; Liao, R; Qiu, Y

2015-07-01

Extracorporeal membrane oxygenation (ECMO) may offer life-saving treatment in severe pulmonary contusion or acute respiratory distress syndrome when conventional treatments have failed. However, because of the bleeding risk of systemic anticoagulation, ECMO should be performed only as a last resort in multiple trauma victims. Here, we report ECMO as a bridge for right main bronchus reconstruction and recovery of traumatic wet lung in a 31-year-old male multi-trauma patient with right main bronchial disruption, bilateral pulmonary contusion, cerebral contusion and long bone fracture. The patient was discharged without any obvious complication. ECMO support in a traumatic brain injured patient with severe hypoxemia caused by lung contusion and/or tracheal bronchus disruption is not an absolute contraindication. © The Author(s) 2014.

Diatomite filters--methods of automation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maloney, G.F.

1966-01-01

Following an introduction of subject material, diatomite filters are discussed in the following categories: a filter system, the manual station, the decision to automate, equipment, the automated filter, and the fail-safe methods. Diagrams and pictures of the equipment and its operation are included. Many aspects of the uses of both the automatic and manually operated diatomite filtering systems are reviewed. The fully automated station may be ideally suited to the remotely located waterflood since it requires virtually no attention or perhaps only periodic inspection. On the other hand, floods large enough to employ full-time personnel, who can maintain a constantmore » vigil and peiodically scrutinize the filtering operation, probably require nothing more than a semiautomatic operation. The reduction of human error can save money, and the introduction of consistency into any unit operation is certain to be beneficial.« less

Peak Discharge, Flood Profile, Flood Inundation, and Debris Movement Accompanying the Failure of the Upper Reservoir at the Taum Sauk Pump Storage Facility near Lesterville, Missouri

USGS Publications Warehouse

Rydlund, Jr., Paul H.

2006-01-01

The Taum Sauk pump-storage hydroelectric power plant located in Reynolds County, Missouri, uses turbines that operate as pumps and hydraulic head generated by discharging water from an upper to a lower reservoir to produce electricity. A 55-acre upper reservoir with a 1.5- billion gallon capacity was built on top of Proffit Mountain, approximately 760 feet above the floodplain of the East Fork Black River. At approximately 5:16 am on December 14, 2005, a 680-foot wide section of the upper reservoir embankment failed suddenly, sending water rushing down the western side of Proffit Mountain and emptying into the floodplain of East Fork Black River. Flood waters from the upper reservoir flowed downstream through Johnson's Shut-Ins State Park and into the lower reservoir of the East Fork Black River. Floods such as this present unique challenges and opportunities to analyze and document peak-flow characteristics, flood profiles, inundation extents, and debris movement. On December 16, 2005, Light Detection and Ranging (LiDAR) data were collected and used to support hydraulic analyses, forensic failure analyses, damage extent, and mitigation of future disasters. To evaluate the impact of sedimentation in the lower reservoir, a bathymetric survey conducted on December 22 and 23, 2005, was compared to a previous bathymetric survey conducted in April, 2005. Survey results indicated the maximum reservoir capacity difference of 147 acre-feet existed at a pool elevation of 730 feet. Peak discharge estimates of 289,000 cubic feet per second along Proffit Mountain and 95,000 cubic feet per second along the East Fork Black River were determined through indirect measurement techniques. The magnitude of the embankment failure flood along the East Fork Black River was approximately 4 times greater than the 100-year flood frequency estimate of 21,900 cubic feet per second, and approximately 3 times greater than the 500-year flood frequency estimate of 30,500 cubic feet per second. Dynamic wave unsteady flow models Dam Break (DAMBRK) and Unsteady NETwork (UNET) were used to route the flood wave from the embankment failure breach of the upper reservoir to the spillway of the lower reservoir. Simulated velocities ranged from 20 to 51 feet per second along Proffit Mountain and 12 to 32 feet per second along the East Fork Black River. Simulated arrival time of the flood wave took approximately 5.5 to 6.0 minutes to enter into the floodplain of the East Fork Black River, and roughly 29 minutes to begin filling the lower reservoir. Simulated shear stress values reached as high as 232 pounds per square foot along the slope of Proffit Mountain and 144 pounds per square foot within the Shut-Ins. Flood depths from the embankment failure may have reached greater than 50 feet along Proffit Mountain and as much as 30 to 40 feet along the East Fork Black River. A steady-state model was used to develop 2-, 5-, 10-, 25-, 50-, 100-, and 500-year flood frequency profiles along the East Fork Black River. A similar flood event, hypothetically resulting from a breach of the east embankment above Taum Sauk Creek, was simulated along with the 100- and 500-year flood profiles on Taum Sauk Creek. Estimated extents of flood inundation were developed for each profile. Debris movement was extensive as a result of the flood wave moving down Proffit Mountain and through Johnson's Shut-Ins State Park. A quantitative assessment of debris movement was conducted to benefit rehabilitation efforts within the park. Approximately 180 acres of timber were affected as a result of the embankment failure flood.

Refrigerated Warehouse Demand Response Strategy Guide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, Doug; Castillo, Rafael; Larson, Kyle

This guide summarizes demand response measures that can be implemented in refrigerated warehouses. In an appendix, it also addresses related energy efficiency opportunities. Reducing overall grid demand during peak periods and energy consumption has benefits for facility operators, grid operators, utility companies, and society. State wide demand response potential for the refrigerated warehouse sector in California is estimated to be over 22.1 Megawatts. Two categories of demand response strategies are described in this guide: load shifting and load shedding. Load shifting can be accomplished via pre-cooling, capacity limiting, and battery charger load management. Load shedding can be achieved by lightingmore » reduction, demand defrost and defrost termination, infiltration reduction, and shutting down miscellaneous equipment. Estimation of the costs and benefits of demand response participation yields simple payback periods of 2-4 years. To improve demand response performance, it’s suggested to install air curtains and another form of infiltration barrier, such as a rollup door, for the passageways. Further modifications to increase efficiency of the refrigeration unit are also analyzed. A larger condenser can maintain the minimum saturated condensing temperature (SCT) for more hours of the day. Lowering the SCT reduces the compressor lift, which results in an overall increase in refrigeration system capacity and energy efficiency. Another way of saving energy in refrigerated warehouses is eliminating the use of under-floor resistance heaters. A more energy efficient alternative to resistance heaters is to utilize the heat that is being rejected from the condenser through a heat exchanger. These energy efficiency measures improve efficiency either by reducing the required electric energy input for the refrigeration system, by helping to curtail the refrigeration load on the system, or by reducing both the load and required energy input.« less

77 FR 54793 - Airworthiness Directives; the Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... was prompted by fuel system reviews conducted by the manufacturer. This AD requires adding design... system must shut off each pump no later than 60 seconds after the fuel tank is emptied. Noting that the... paragraph (g)(2): ``The pump shutoff system design must preclude undetected running of a fuel pump in an...

40 CFR 63.5767 - What records must I keep?

Code of Federal Regulations, 2013 CFR

2013-07-01

... facility is not controlled by an add-on control device (i.e., you are complying with organic HAP content... add-on control device, you must keep the records specified in § 63.10(b) relative to control device startup, shut down, and malfunction events; control device performance tests; and continuous monitoring...

40 CFR 63.5767 - What records must I keep?

Code of Federal Regulations, 2012 CFR

2012-07-01

... facility is not controlled by an add-on control device (i.e., you are complying with organic HAP content... add-on control device, you must keep the records specified in § 63.10(b) relative to control device startup, shut down, and malfunction events; control device performance tests; and continuous monitoring...

40 CFR 63.5767 - What records must I keep?

Code of Federal Regulations, 2014 CFR

2014-07-01

... facility is not controlled by an add-on control device (i.e., you are complying with organic HAP content... add-on control device, you must keep the records specified in § 63.10(b) relative to control device startup, shut down, and malfunction events; control device performance tests; and continuous monitoring...

Use of a Modern Polymerization Pilot-Plant for Undergraduate Control Projects.

ERIC Educational Resources Information Center

Mendoza-Bustos, S. A.; And Others

1991-01-01

Described is a project where students gain experience in handling large volumes of hazardous materials, process start up and shut down, equipment failures, operational variations, scaling up, equipment cleaning, and run-time scheduling while working in a modern pilot plant. Included are the system design, experimental procedures, and results. (KR)

CONTROL ROD ROTATING MECHANISM

DOEpatents

Baumgarten, A.; Karalis, A.J.

1961-11-28

A threaded rotatable shaft is provided which rotates in response to linear movement of a nut, the shaft being surrounded by a pair of bellows members connected to either side of the nut to effectively seal the reactor from leakage and also to store up energy to shut down the reactor in the event of a power failure. (AEC)

30 CFR 250.502 - Equipment movement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... District Manager. A closed surface-controlled subsurface safety valve of the pump-through type may be used in lieu of the pump-through-type tubing plug, provided that the surface control has been locked out... be shut in below the surface with a pump-through-type tubing plug and at the surface with a closed...

30 CFR 250.602 - Equipment movement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... otherwise approved by the District Manager. A closed surface-controlled subsurface safety valve of the pump-through-type may be used in lieu of the pump-through-type tubing plug provided that the surface control... producing hydrocarbons shall be shut in below the surface with a pump-through-type tubing plug and at the...

30 CFR 250.602 - Equipment movement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... District Manager. A closed surface-controlled subsurface safety valve of the pump-through-type may be used in lieu of the pump-through-type tubing plug provided that the surface control has been locked out of... be shut in below the surface with a pump-through-type tubing plug and at the surface with a closed...

30 CFR 250.602 - Equipment movement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... District Manager. A closed surface-controlled subsurface safety valve of the pump-through-type may be used in lieu of the pump-through-type tubing plug provided that the surface control has been locked out of... be shut in below the surface with a pump-through-type tubing plug and at the surface with a closed...