Sample records for failure corona incremental

  1. Corona-vacuum failure mechanism test facilities

    NASA Technical Reports Server (NTRS)

    Lalli, V. R.; Mueller, L. A.; Koutnik, E. A.

    1975-01-01

    A nondestructive corona-vacuum test facility for testing high-voltage power system components has been developed using commercially available hardware. The facility simulates operating temperature and vacuum while monitoring coronal discharges with residual gases. Corona threshold voltages obtained from statorette tests with various gas-solid dielectric systems and comparison with calculated data support the following conclusions: (1) air gives the highest corona threshold voltage and helium the lowest, with argon and helium-xenon mixtures intermediate; (2) corona threshold voltage increases with gas pressure; (3) corona threshold voltage for an armature winding can be accurately calculated by using Paschen curves for a uniform field; and (4) Paschen curves for argon can be used to calculate the corona threshold voltage in He-Xe mixtures, for which Paschen curves are unavailable.-

  2. Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH.

    PubMed

    van der Velde, A Rogier; Gullestad, Lars; Ueland, Thor; Aukrust, Pål; Guo, Yu; Adourian, Aram; Muntendam, Pieter; van Veldhuisen, Dirk J; de Boer, Rudolf A

    2013-03-01

    In several cross-sectional analyses, circulating baseline levels of galectin-3, a protein involved in myocardial fibrosis and remodeling, have been associated with increased risk for morbidity and mortality in patients with heart failure (HF). The importance and clinical use of repeated measurements of galectin-3 have not yet been reported. Plasma galectin-3 was measured at baseline and at 3 months in patients enrolled in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) trial (n=1329), and at baseline and at 6 months in patients enrolled in the Coordinating Study Evaluating Outcomes of Advising and Counseling Failure (COACH) trial (n=324). Patient results were analyzed by categorical and percentage changes in galectin-3 level. A threshold value of 17.8 ng/mL or 15% change from baseline was used to categorize patients. Increasing galectin-3 levels over time, from a low to high galectin-3 category, were associated with significantly more HF hospitalization and mortality compared with stable or decreasing galectin-3 levels (hazard ratio in CORONA, 1.60; 95% confidence interval, 1.13-2.25; P=0.007; hazard ratio in COACH, 2.38; 95% confidence interval, 1.02-5.55; P=0.046). In addition, patients whose galectin-3 increased by >15% between measurements had a 50% higher relative hazard of adverse event than those whose galectin-3 stayed within ±15% of the baseline value, independent of age, sex, diabetes mellitus, left ventricular ejection fraction, renal function, medication (β-blocker, angiotensin converting enzyme inhibitor, and angiotensin receptor blocker), and N-terminal probrain natriuretic peptide (hazard ratio in CORONA, 1.50; 95% confidence interval, 1.17-1.92; P=0.001). The impact of changing galectin-3 levels on other secondary end points was comparable. In 2 large cohorts of patients with chronic and acute decompensated HF, repeated measurements of galectin-3 level provided important and significant prognostic value in identifying

  3. Echocardiography and risk prediction in advanced heart failure: incremental value over clinical markers.

    PubMed

    Agha, Syed A; Kalogeropoulos, Andreas P; Shih, Jeffrey; Georgiopoulou, Vasiliki V; Giamouzis, Grigorios; Anarado, Perry; Mangalat, Deepa; Hussain, Imad; Book, Wendy; Laskar, Sonjoy; Smith, Andrew L; Martin, Randolph; Butler, Javed

    2009-09-01

    Incremental value of echocardiography over clinical parameters for outcome prediction in advanced heart failure (HF) is not well established. We evaluated 223 patients with advanced HF receiving optimal therapy (91.9% angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, 92.8% beta-blockers, 71.8% biventricular pacemaker, and/or defibrillator use). The Seattle Heart Failure Model (SHFM) was used as the reference clinical risk prediction scheme. The incremental value of echocardiographic parameters for event prediction (death or urgent heart transplantation) was measured by the improvement in fit and discrimination achieved by addition of standard echocardiographic parameters to the SHFM. After a median follow-up of 2.4 years, there were 38 (17.0%) events (35 deaths; 3 urgent transplants). The SHFM had likelihood ratio (LR) chi(2) 32.0 and C statistic 0.756 for event prediction. Left ventricular end-systolic volume, stroke volume, and severe tricuspid regurgitation were independent echocardiographic predictors of events. The addition of these parameters to SHFM improved LR chi(2) to 72.0 and C statistic to 0.866 (P < .001 and P=.019, respectively). Reclassifying the SHFM-predicted risk with use of the echocardiography-added model resulted in improved prognostic separation. Addition of standard echocardiographic variables to the SHFM results in significant improvement in risk prediction for patients with advanced HF.

  4. Early Shear Failure Prediction in Incremental Sheet Forming Process Using FEM and ANN

    NASA Astrophysics Data System (ADS)

    Moayedfar, Majid; Hanaei, Hengameh; Majdi Rani, Ahmad; Musa, Mohd Azam Bin; Sadegh Momeni, Mohammad

    2018-03-01

    The application of incremental sheet forming process as a rapid forming technique is rising in variety of industries such as aerospace, automotive and biomechanical purposes. However, the sheet failure is a big challenge in this process which leads wasting lots of materials. Hence, this study tried to propose a method to predict the early sheet failure in this process using mathematical solution. For the feasibility of the study, design of experiment with the respond surface method is employed to extract a set of experiments data for the simulation. The significant forming parameters were recognized and their integration was used for prediction system. Then, the results were inserted to the artificial neural network as input parameters to predict a vast range of applicable parameters avoiding sheet failure in ISF. The value of accuracy R2 ∼0.93 was obtained and the maximum sheet stretch in the depth of 25mm were recorded. The figures generate from the trend of interaction between effective parameters were provided for future studies.

  5. Characteristics of a corona discharge with a hot corona electrode

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kulumbaev, E. B.; Lelevkin, V. M.; Niyazaliev, I. A.

    The effect of the temperature of the corona electrode on the electrical characteristics of a corona discharge was studied experimentally. A modified Townsend formula for the current-voltage characteristic of a one-dimensional corona is proposed. Gasdynamic and thermal characteristics of a positive corona discharge in a coaxial electrode system are calculated. The calculated results are compared with the experimental data.

  6. The prominence-corona interface and its relationship to the chromosphere-corona transition

    NASA Technical Reports Server (NTRS)

    Rabin, Douglas

    1986-01-01

    The classical model of the chromosphere-corona transition does not account for the observed behavior of the differential emission measure for T approx. less than 100,000 K. Several models have been proposed to resolve this discrepancy in physically different ways. Because the observed differential emission measure at the prominence-corona interface is on average nearly the same as in the chromosphere-corona transition, prominences offer a fresh testing ground for models tailored to the chromosphere-corona transition. The researcher considered three such models and concluded that none extends in a natural way to the environment of prominences. The researcher advanced a simple idea involving thermal conduction both along and across the magnetic field from the corona into cool threads.

  7. A Statistical Analysis of Corona Topography: New Insights into Corona Formation and Evolution

    NASA Technical Reports Server (NTRS)

    Stofan, E. R.; Glaze, L. S.; Smrekar, S. E.; Baloga, S. M.

    2003-01-01

    Extensive mapping of the surface of Venus and continued analysis of Magellan data have allowed a more comprehensive survey of coronae to be conducted. Our updated corona database contains 514 features, an increase from the 326 coronae of the previous survey. We include a new set of 106 Type 2 or stealth coronae, which have a topographic rather than a fracture annulus. The large increase in the number of coronae over the 1992 survey results from several factors, including the use of the full Magellan data set and the addition of features identified as part of the systematic geologic mapping of Venus. Parameters of the population that we have analyzed to date include size and topography.

  8. Correlation between audible noise and corona current generated by AC corona discharge in time and frequency domains

    NASA Astrophysics Data System (ADS)

    Li, Xuebao; Wang, Jing; Li, Yinfei; Zhang, Qian; Lu, Tiebing; Cui, Xiang

    2018-06-01

    Corona-generated audible noise is induced by the collisions between space charges and air molecules. It has been proven that there is a close correlation between audible noise and corona current from DC corona discharge. Analysis on the correlation between audible noise and corona current can promote the cognition of the generation mechanism of corona discharge. In this paper, time-domain waveforms of AC corona-generated audible noise and corona current are measured simultaneously. The one-to-one relationship between sound pressure pulses and corona current pulses can be found and is used to remove the interferences from background noise. After the interferences are removed, the linear correlated relationships between sound pressure pulse amplitude and corona current pulse amplitude are obtained through statistical analysis. Besides, frequency components at the harmonics of power frequency (50 Hz) can be found both in the frequency spectrums of audible noise and corona current through frequency analysis. Furthermore, the self-correlation relationships between harmonic components below 400 Hz with the 50 Hz component are analyzed for audible noise and corona current and corresponding empirical formulas are proposed to calculate the harmonic components based on the 50 Hz component. Finally, based on the AC corona discharge process and generation mechanism of audible noise and corona current, the correlation between audible noise and corona current in time domain and frequency domain are interpreted qualitatively. Besides, with the aid of analytical expressions of periodic square waves, sound pressure pulses, and corona current pulses, the modulation effects from the AC voltage on the pulse trains are used to interpret the generation of the harmonic components of audible noise and corona current.

  9. Ultrasonic corona sensor study

    NASA Technical Reports Server (NTRS)

    Harrold, R. T.

    1976-01-01

    The overall objective of this program is to determine the feasibility of using ultrasonic (above 20 kHz) corona detection techniques to detect low order (non-arcing) coronas in varying degrees of vacuum within large high vacuum test chambers, and to design, fabricate, and deliver a prototype ultrasonic corona sensor.

  10. PULSE ENERGIZATION IN THE TUFT CORONA REGIME OF NEGATIVE CORONA

    EPA Science Inventory

    The paper discusses pulse energization in the tuft corona regime of negative corona. Fabric filtration, with integral particle charging and collection in a combined electric and flow field, is sensitive to maldistribution of current among bags energized by one power source, espec...

  11. Are Coronae Restricted to Venus?: Corona-Like Tectonovolcanic Structures on Earth

    NASA Astrophysics Data System (ADS)

    Lopez, Ivan; Marquez, Alvaro; Oyarzun, Roberto

    1997-04-01

    Coronae may not be tectonovolcanic features ‘unique to Venus’ because both the processes that lead to corona formation, and their final tectonovolcanic output (formation of domes, plateaus, extensional rings, etc.), are also found on Earth. Large-scale corona formation processes on Earth may be restricted (because of plate motion) but not absent. The same applies to resurfacing processes. We here suggest that at least, the early stages of corona formation can be recognized in intraplate tectonic settings on Earth. The African plate displays many Cenozoic examples of plume-related domal uplifts and volcanism (e.g., Hoggar, Tibesti, Darfur, Ethiopia). Furthermore, the east African rift system (EARS) around lake Victoria displays many striking features that resemble those of the Venus coronae associated with extensional belts. Among these are the following: (1) an overall elliptical shape; (2) the existence of a mantle plume (Kenya plume) centered beneath lake Victoria; (3) a central plateau (east African plateau); (4) an external extensional belt (the EARS east and west branches); (5) doming processes (Kenya dome); and last but not least (6) volcanism.

  12. Complementary analysis of the hard and soft protein corona: sample preparation critically effects corona composition.

    PubMed

    Winzen, S; Schoettler, S; Baier, G; Rosenauer, C; Mailaender, V; Landfester, K; Mohr, K

    2015-02-21

    Here we demonstrate how a complementary analysis of nanocapsule-protein interactions with and without application media allows gaining insights into the so called hard and soft protein corona. We have investigated how both human plasma and individual proteins (human serum albumin (HSA), apolipoprotein A-I (ApoA-I)) adsorb and interact with hydroxyethyl starch (HES) nanocapsules possessing different functionalities. To analyse the hard protein corona we used sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and a protein quantitation assay. No significant differences were observed with regards to the hard protein corona. For analysis of the soft protein corona we characterized the nanocapsule-protein interaction with isothermal titration calorimetry (ITC) and dynamic light scattering (DLS). DLS and ITC measurements revealed that a high amount of plasma proteins were adsorbed onto the capsules' surface. Although HSA was not detected in the hard protein corona, ITC measurements indicated the adsorption of an HSA amount similar to plasma with a low binding affinity and reaction heat. In contrast, only small amounts of ApoA-I protein adsorb to the capsules with high binding affinities. Through a comparison of these methods we have identified ApoA-I to be a component of the hard protein corona and HSA as a component of the soft corona. We demonstrate a pronounced difference in the protein corona observed depending on the type of characterization technique applied. As the biological identity of a particle is given by the protein corona it is crucial to use complementary characterization techniques to analyse different aspects of the protein corona.

  13. Measurement and analysis of time-domain characteristics of corona-generated radio interference from a single positive corona source

    NASA Astrophysics Data System (ADS)

    Li, Xuebao; Li, Dayong; Chen, Bo; Cui, Xiang; Lu, Tiebing; Li, Yinfei

    2018-04-01

    The corona-generated electromagnetic interference commonly known as radio interference (RI) has become a limiting factor for the design of high voltage direct current transmission lines. In this paper, a time-domain measurement system is developed to measure the time-domain characteristics of corona-generated RI from a single corona source under a positive corona source. In the experiments, the corona current pulses are synchronously measured through coupling capacitors. The one-to-one relationship between the corona current pulse and measured RI voltage pulse is observed. The statistical characteristics of pulse parameters are analyzed, and the correlations between the corona current pulse and RI voltage pulse in the time-domain and frequency-domain are analyzed. Depending on the measured corona current pulses, the time-domain waveform of corona-generated RI is calculated on the basis of the propagation model of corona current on the conductor, the dipolar model for electric field calculation, and the antenna model for inducing voltage calculation. The well matched results between measured and simulated waveforms of RI voltage can show the validity of the measurement and calculation method presented in this paper, which also further show the close correlation between corona current and corona-generated RI.

  14. Solar Corona Explorer: A mission for the physical diagnosis of the solar corona

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Mission objectives and spacecraft requirements for the Solar Corona Explorer (SCE), a proposed free flying, unmanned solar research craft to be tenatively launched in 1987, were defined. The SCE's purpose is to investigate structure, dynamics and evolution of the corona, globally and in the required physical detail, to study the close coupling between the inner corona and the heliosphere. Investigative objectives are: (1) to understand the corona as the source of varying interplanetary plasma and of varying solar X-ray and extreme ultraviolet fluxes; (2) to develop the capabilities to model the corona with sufficient precision to forecast the Earth's variable environment in space, on the scales from weeks to years; (3) to develop an understanding of the physical processes that determine the dynamics and physical state of the coronal plasma, particularly acceleration processes; and (4) to develop insight and test theory on the Sun applicable to stellar coronae and winds, and in particular, to understand why cool stars put such a large fraction of their energy into X-rays. Considered related factors are: (1) duration of the mission; (2) onboard measuring instrumentation; (3) ground support equipment and procedures; and (4) programs of interpretation and modeling.

  15. Insights into Corona Formation through Statistical Analyses

    NASA Technical Reports Server (NTRS)

    Glaze, L. S.; Stofan, E. R.; Smrekar, S. E.; Baloga, S. M.

    2002-01-01

    Statistical analysis of an expanded database of coronae on Venus indicates that the populations of Type 1 (with fracture annuli) and 2 (without fracture annuli) corona diameters are statistically indistinguishable, and therefore we have no basis for assuming different formation mechanisms. Analysis of the topography and diameters of coronae shows that coronae that are depressions, rimmed depressions, and domes tend to be significantly smaller than those that are plateaus, rimmed plateaus, or domes with surrounding rims. This is consistent with the model of Smrekar and Stofan and inconsistent with predictions of the spreading drop model of Koch and Manga. The diameter range for domes, the initial stage of corona formation, provides a broad constraint on the buoyancy of corona-forming plumes. Coronae are only slightly more likely to be topographically raised than depressions, with Type 1 coronae most frequently occurring as rimmed depressions and Type 2 coronae most frequently occuring with flat interiors and raised rims. Most Type 1 coronae are located along chasmata systems or fracture belts, while Type 2 coronas are found predominantly as isolated features in the plains. Coronae at hotspot rises tend to be significantly larger than coronae in other settings, consistent with a hotter upper mantle at hotspot rises and their active state.

  16. International Space Station (ISS) S-Band Corona Discharge Anomaly Consultation

    NASA Technical Reports Server (NTRS)

    Kichak, Robert A.; Leidecker, Henning; Battel, Steven; Ruitberg, Arthur; Sank, Victor

    2008-01-01

    The Assembly and Contingency Radio Frequency Group (ACRFG) onboard the International Space Station (ISS) is used for command and control communications and transmits (45 dBm or 32 watts) and receives at S-band. The system is nominally pressurized with gaseous helium (He) and nitrogen (N2) at 8 pounds per square inch absolute (psia). MacDonald, Dettwiler and Associates Ltd. (MDA) was engaged to analyze the operational characteristics of this unit in an effort to determine if the anomalous behavior was a result of a corona event. Based on this analysis, MDA did not recommend continued use of this ACRFG. The NESC was requested to provide expert support in the area of high-voltage corona and multipactoring in an S-Band RF system and to assess the probability of corona occurring in the ACRFG during the planned EVA. The NESC recommended minimal continued use of S/N 002 ACRFG until a replacement unit can be installed. Following replacement, S/N 002 will be subjected to destructive failure analysis in an effort to determine the proximate and root cause(s) of the anomalous behavior.

  17. Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure.

    PubMed

    Ahmadian, Mehdi; Roshan, Valiollah Dabidi; Aslani, Elaheh; Stannard, Stephen R

    2017-07-01

    The purpose of this study was to examine the anti-atherogenic and anti-inflammatory effect of supplemental taurine prior to and following incremental exercise in patients with heart failure (HF). Patients with HF and left ventricle ejection fraction less than 50%, and placed in functional class II or III according to the New York Heart Association classification, were randomly assigned to two groups: (1) taurine supplementation; or (2) placebo. The taurine group received oral taurine (500 mg) 3 times a day for 2 weeks, and performed exercise before and after the supplementation period. The placebo group followed the same protocol, but with a starch supplement (500 mg) rather than taurine. The incremental multilevel treadmill test was done using a modified Bruce protocol. Our results indicate that inflammatory indices [C-reactive protein (CRP), platelets] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05) whereas these indices increased in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation in the placebo group ( p < 0.05). Our results also show that atherogenic indices [Castelli's Risk Index-I (CRI-I), Castelli's Risk Index-II (CRI-II) and Atherogenic Coefficient (AC)] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05). No such changes were noted in the placebo group ( p > 0.05). our results suggest that 2 weeks of oral taurine supplementation increases the taurine levels and has anti-atherogenic and anti-inflammatory effects prior to and following incremental exercise in HF patients.

  18. Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: an analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).

    PubMed

    Badar, Athar A; Perez-Moreno, Ana Cristina; Jhund, Pardeep S; Wong, Chih M; Hawkins, Nathaniel M; Cleland, John G F; van Veldhuisen, Dirk J; Wikstrand, John; Kjekshus, John; Wedel, Hans; Watkins, Stuart; Gardner, Roy S; Petrie, Mark C; McMurray, John J V

    2014-12-21

    Angina pectoris is common in patients with heart failure and reduced ejection fraction (HF-REF) but its relationship with outcomes has not been well defined. This relationship was investigated further in a retrospective analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). Four thousand, eight hundred and seventy-eight patients were divided into three categories: no history of angina and no chest pain at baseline (Group A; n = 1240), past history of angina but no chest pain at baseline (Group B; n = 1353) and both a history of angina and chest pain at baseline (Group C; n = 2285). Outcomes were examined using Kaplan-Meier and Cox regression survival analysis. Compared with Group A, Group C had a higher risk of non-fatal myocardial infarction or unstable angina (HR: 2.36, 1.54-3.61; P < 0.001), this composite plus coronary revascularization (HR: 2.54, 1.76-3.68; P < 0.001), as well as HF hospitalization (HR: 1.35, 1.13-1.63; P = 0.001), over a median follow-up period of 33 months. There was no difference in cardiovascular or all-cause mortality. Group B had a smaller increase in risk of coronary events but not of heart failure hospitalization. Patients with HF-REF and ongoing angina are at an increased risk of acute coronary syndrome and HF hospitalization. Whether these patients would benefit from more aggressive medical therapy or percutaneous revascularization is not known and merits further investigation. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  19. Shell-corona microgels from double interpenetrating networks.

    PubMed

    Rudyak, Vladimir Yu; Gavrilov, Alexey A; Kozhunova, Elena Yu; Chertovich, Alexander V

    2018-04-18

    Polymer microgels with a dense outer shell offer outstanding features as universal carriers for different guest molecules. In this paper, microgels formed by an interpenetrating network comprised of collapsed and swollen subnetworks are investigated using dissipative particle dynamics (DPD) computer simulations, and it is found that such systems can form classical core-corona structures, shell-corona structures, and core-shell-corona structures, depending on the subchain length and molecular mass of the system. The core-corona structures consisting of a dense core and soft corona are formed at small microgel sizes when the subnetworks are able to effectively separate in space. The most interesting shell-corona structures consist of a soft cavity in a dense shell surrounded with a loose corona, and are found at intermediate gel sizes; the area of their existence depends on the subchain length and the corresponding mesh size. At larger molecular masses the collapsing network forms additional cores inside the soft cavity, leading to the core-shell-corona structure.

  20. Statistical characteristic in time-domain of direct current corona-generated audible noise from conductor in corona cage

    NASA Astrophysics Data System (ADS)

    Li, Xuebao; Cui, Xiang; Lu, Tiebing; Ma, Wenzuo; Bian, Xingming; Wang, Donglai; Hiziroglu, Huseyin

    2016-03-01

    The corona-generated audible noise (AN) has become one of decisive factors in the design of high voltage direct current (HVDC) transmission lines. The AN from transmission lines can be attributed to sound pressure pulses which are generated by the multiple corona sources formed on the conductor, i.e., transmission lines. In this paper, a detailed time-domain characteristics of the sound pressure pulses, which are generated by the DC corona discharges formed over the surfaces of a stranded conductors, are investigated systematically in a laboratory settings using a corona cage structure. The amplitude of sound pressure pulse and its time intervals are extracted by observing a direct correlation between corona current pulses and corona-generated sound pressure pulses. Based on the statistical characteristics, a stochastic model is presented for simulating the sound pressure pulses due to DC corona discharges occurring on conductors. The proposed stochastic model is validated by comparing the calculated and measured A-weighted sound pressure level (SPL). The proposed model is then used to analyze the influence of the pulse amplitudes and pulse rate on the SPL. Furthermore, a mathematical relationship is found between the SPL and conductor diameter, electric field, and radial distance.

  1. Cardio-pulmonary responses to incremental eccentric and concentric cycling tests to task failure.

    PubMed

    Lipski, Marcin; Abbiss, Chris R; Nosaka, Kazunori

    2018-05-01

    This study compared cardio-pulmonary responses between incremental concentric and eccentric cycling tests, and examined factors affecting the maximal eccentric cycling capacity. On separate days, nine men and two women (32.6 ± 9.4 years) performed an upright seated concentric (CON) and an eccentric (ECC) cycling test, which started at 75 W and increased 25 W min -1 until task failure. Gas exchange, heart rate (HR) and power output were continuously recorded during the tests. Participants also performed maximal voluntary contractions of the quadriceps (MVC), squat and countermovement jumps. Peak power output was 53% greater (P < 0.001, g = 1.77) for ECC (449 ± 115 W) than CON (294 ± 61 W), but peak oxygen consumption was 43% lower (P < 0.001, g = 2.18) for ECC (30.6 ± 5.6 ml kg min -1 ) than CON (43.9 ± 6.9 ml kg min -1 ). Maximal HR was not different between ECC (175 ± 20 bpm) and CON (182 ± 13 bpm), but the increase in HR relative to oxygen consumption was 33% greater (P = 0.01) during ECC than CON. Moderate to strong correlations (P < 0.05) were observed between ECC peak power output and CON peak power (r = 0.84), peak oxygen consumption (r = 0.54) and MVC (r = 0.53), while no significant relationships were observed between ECC peak power output and squat as well as countermovement jump heights. Unexpectedly, maximal HR was similar between CON and ECC. Although ECC power output can be predicted from CON peak power output, an incremental eccentric cycling test performed after 3-6 familiarisation sessions may be useful in programming ECC training with healthy and accustomed individuals.

  2. Statistical characteristic in time-domain of direct current corona-generated audible noise from conductor in corona cage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Xuebao, E-mail: lxb08357x@ncepu.edu.cn; Cui, Xiang, E-mail: x.cui@ncepu.edu.cn; Ma, Wenzuo

    The corona-generated audible noise (AN) has become one of decisive factors in the design of high voltage direct current (HVDC) transmission lines. The AN from transmission lines can be attributed to sound pressure pulses which are generated by the multiple corona sources formed on the conductor, i.e., transmission lines. In this paper, a detailed time-domain characteristics of the sound pressure pulses, which are generated by the DC corona discharges formed over the surfaces of a stranded conductors, are investigated systematically in a laboratory settings using a corona cage structure. The amplitude of sound pressure pulse and its time intervals aremore » extracted by observing a direct correlation between corona current pulses and corona-generated sound pressure pulses. Based on the statistical characteristics, a stochastic model is presented for simulating the sound pressure pulses due to DC corona discharges occurring on conductors. The proposed stochastic model is validated by comparing the calculated and measured A-weighted sound pressure level (SPL). The proposed model is then used to analyze the influence of the pulse amplitudes and pulse rate on the SPL. Furthermore, a mathematical relationship is found between the SPL and conductor diameter, electric field, and radial distance.« less

  3. Biomolecular Corona Dictates Aβ Fibrillation Process.

    PubMed

    Lotfabadi, Alireza; Hajipour, Mohammad Javad; Derakhshankhah, Hossein; Peirovi, Afshin; Saffar, Samaneh; Shams, Elnaz; Fatemi, Elnaz; Barzegari, Ebrahim; Sarvari, Sajad; Moakedi, Faezeh; Ferdousi, Maryam; Atyabi, Fatemeh; Saboury, Ali Akbar; Dinarvand, Rassoul

    2018-04-30

    Amyloid beta (Aβ), which forms toxic oligomers and fibrils in brain tissues of patients with Alzheimer's disease, is broadly used as a model protein to probe the effect of nanoparticles (NPs) on oligomerization and fibrillation processes. However, the majority of the reports in the field have ignored the effect of the biomolecular corona on the fibrillogenesis of the Aβ proteins. The biomolecular corona, which is a layer composed of various types of biomolecules that covers the surface of NPs upon their interaction with biological fluids, determines the biological fates of NPs. Therefore, during in vivo interaction of NPs with Aβ protein, what the Aβ actually "sees" is the human plasma and/or cerebrospinal fluid (CSF) biomolecular-coated NPs rather than the pristine surface of NPs. Here, to mimic the in vivo effects of therapeutic NPs as antifibrillation agents, we probed the effects of a biomolecular corona derived from human CSF and/or plasma on Aβ fibrillation. The results demonstrated that the type of biomolecular corona can dictate the inhibitory or acceleratory effect of NPs on Aβ 1-42 and Aβ 25-35 fibrillation processes. More specifically, we found that the plasma biomolecular-corona-coated gold NPs, with sphere and rod shapes, has less inhibitory effect on Aβ 1-42 fibrillation kinetics compared with CSF biomolecular-corona-coated and pristine NPs. Opposite results were obtained for Aβ 25-35 peptide, where the pristine NPs accelerated the Aβ 25-35 fibrillation process, whereas corona-coated ones demonstrated an inhibitory effect. In addition, the CSF biomolecular corona had less inhibitory effect than those obtained from plasma.

  4. Tectonic patterns and regional stresses near Venusian coronae

    NASA Astrophysics Data System (ADS)

    Cyr, K. E.; Melosh, H. J.

    1993-04-01

    A stress analysis of tectonic patterns near Venusian coronae is reported. Combined local corona stresses and uniform regional stresses are used to predict patterns of surface tectonic features. The patterns are compared to those of coronae on Magellan images to determine the regional stress and elastic lithospheric thickness about the coronae. Regional stresses of 0.1-0.6 kbar and elastic lithospheric thicknesses of 10 +/- 5 km are estimated for three specific coronae.

  5. Some crucial corona and prominence observations

    NASA Technical Reports Server (NTRS)

    Tandberg-Hanssen, E. A.

    1986-01-01

    A number of theories and hypotheses are currently being developed to explain the often complex behavior of corona and prominence plasmas. In order to test the theories and hypotheses certain crucial observations are necessary. Some of these observations are examined and a few conclusions are drawn. Corona mass balance, corona and prominence classifications, prominence formation and stability, and coronal mass ejection are dicussed.

  6. Large-scale volcanism associated with coronae on Venus

    NASA Technical Reports Server (NTRS)

    Roberts, K. Magee; Head, James W.

    1993-01-01

    The formation and evolution of coronae on Venus are thought to be the result of mantle upwellings against the crust and lithosphere and subsequent gravitational relaxation. A variety of other features on Venus have been linked to processes associated with mantle upwelling, including shield volcanoes on large regional rises such as Beta, Atla and Western Eistla Regiones and extensive flow fields such as Mylitta and Kaiwan Fluctus near the Lada Terra/Lavinia Planitia boundary. Of these features, coronae appear to possess the smallest amounts of associated volcanism, although volcanism associated with coronae has only been qualitatively examined. An initial survey of coronae based on recent Magellan data indicated that only 9 percent of all coronae are associated with substantial amounts of volcanism, including interior calderas or edifices greater than 50 km in diameter and extensive, exterior radial flow fields. Sixty-eight percent of all coronae were found to have lesser amounts of volcanism, including interior flooding and associated volcanic domes and small shields; the remaining coronae were considered deficient in associated volcanism. It is possible that coronae are related to mantle plumes or diapirs that are lower in volume or in partial melt than those associated with the large shields or flow fields. Regional tectonics or variations in local crustal and thermal structure may also be significant in determining the amount of volcanism produced from an upwelling. It is also possible that flow fields associated with some coronae are sheet-like in nature and may not be readily identified. If coronae are associated with volcanic flow fields, then they may be a significant contributor to plains formation on Venus, as they number over 300 and are widely distributed across the planet. As a continuation of our analysis of large-scale volcanism on Venus, we have reexamined the known population of coronae and assessed quantitatively the scale of volcanism associated

  7. Parga Chasma: Coronae and Rifting on Venus

    NASA Technical Reports Server (NTRS)

    Smrekar, S. E.; Stofan, E. R.; Buck, W. R.; Martin, P.

    2005-01-01

    The majority of coronae (quasicircular volcano-tectonic features) are found along rifts or fracture belts, and the majority of rifts have coronae [e.g. 1,2]. However, the relationship between coronae and rifts remains unclear [3-6]. There is evidence that coronae can form before, after, or synchronously with rifts [3,4]. The extensional fractures in the rift zones have been proposed to be a result of broad scale upwelling and traction on the lower lithosphere [7]. However, not all rift systems have a significant positive geoid anomaly, as would be expected for an upwelling site [8]. This could be explained if the rifts lacking anomalies are no longer active. Coronae are generally accepted to be sites of local upwelling [e.g. 1], but the observed rifting is frequently not radial to the coronae and extends well beyond the coronae into the surrounding plains. Thus the question remains as to whether the rifts represent regional extension, perhaps driven by mantle tractions, or if the coronae themselves create local thinning and extension of the lithosphere. In the first case, a regional extension model should be consistent with the observed characteristics of the rifts. In the latter case, a model of lithospheric loading and fracturing would be more appropriate. A good analogy may be the propagation of oceanic intraplate volcanoes [9].

  8. Nova Superposed on Yavine Corona

    NASA Image and Video Library

    1998-06-04

    The view from NASA's Magellan spacecraft shows a 100-km-wide nova superposed on Yavine Corona. Coronae are roughly circular, volcanic features believed to form over hot upwellings of magma within the Venusian mantle. http://photojournal.jpl.nasa.gov/catalog/PIA00150

  9. A Connection Between Corona and Jet

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2017-03-01

    The structure immediately around a supermassive black hole at the heart of an active galaxy can tell us about how material flows in and out of these monsters but this region is hard to observe! A new study provides us with clues of what might be going on in these active and energetic cores of galaxies.In- and OutflowsIn active galactic nuclei (AGN), matter flows both in and out. As material flows toward the black hole via its surrounding accretion disk, much of this gas and dust can then be expelled from the vicinity via highly collimated jets.Top: The fraction of X-rays that is reflected decreases as jet power increases. Bottom: the distance between the corona and the reflecting part of the disk increases as jet power increases. [Adapted from King et al. 2017]To better understand this symbiosis between accretion and outflows, we examine whats known as the corona the hot, X-ray-emitting gas thats located in the closest regions around the black hole. But because the active centers of galaxies are generally obscured by surrounding gas and dust, its difficult for us to learn about the structure of these inner regions near the black hole.Where are the X-rays of the corona produced: in the inner accretion flow, or at the base of the jet? How far away is this corona from the disk? And how does the coronas behavior relate to that of the jet?Reflected ObservationsTo address some of these questions, a group of scientists led by Ashley King (Einstein Fellow at Stanford University) has analyzed X-ray observations from NuSTAR and XMM-Newton of over 40 AGN. The team examined the reflections of the X-rays off of the accretion disk and used two measurements to learn about the structure around the black hole:the fraction of the coronas X-rays that are reflected by the disk, andthe time lag between the original and reflected X-rays, which reveals the distance from the corona to the reflecting part of the disk.A visualization of the authors model for an AGN. The accretion disk is

  10. Anger, Hostility, and Re-hospitalizations in Patients with Heart Failure

    DTIC Science & Technology

    2015-04-08

    Discharge Survey (NHDS), capturing years 1979 to 2004, approximately 80% of individuals who were hospitalized due to heart failure were ~65...Rosuvastatin Multinational Trial In Heart Failure ( CORONA ). Circulation. Heart failure 2. Azevedo FB, Wang YP, Goulart AC, Lotufo PA, Bensenor IM. 2010...from the National Hospital Discharge Surveys 1980-2006. International journal of cardiology 149:39-45 33 . Luttik ML, Jaarsma T, Moser DK, Sanderman R

  11. Global Magnetohydrodynamic Modeling of the Solar Corona

    NASA Technical Reports Server (NTRS)

    Linker, Jon A.; Wagner, William (Technical Monitor)

    2001-01-01

    The solar corona, the hot, tenuous outer atmosphere of the Sun, exhibits many fascinating phenomena on a wide range of scales. One of the ways that the Sun can affect us here at Earth is through the large-scale structure of the corona and the dynamical phenomena associated with it, as it is the corona that extends outward as the solar wind and encounters the Earth's magnetosphere. The goal of our research sponsored by NASA's Supporting Research and Technology Program in Solar Physics is to develop increasingly realistic models of the large-scale solar corona, so that we can understand the underlying properties of the coronal magnetic field that lead to the observed structure and evolution of the corona. We describe the work performed under this contract.

  12. Single point incremental forming: Formability of PC sheets

    NASA Astrophysics Data System (ADS)

    Formisano, A.; Boccarusso, L.; Carrino, L.; Lambiase, F.; Minutolo, F. Memola Capece

    2018-05-01

    Recent research on Single Point Incremental Forming of polymers has slightly covered the possibility of expanding the materials capability window of this flexible forming process beyond metals, by demonstrating the workability of thermoplastic polymers at room temperature. Given the different behaviour of polymers compared to metals, different aspects need to be deepened to better understand the behaviour of these materials when incrementally formed. Thus, the aim of the work is to investigate the formability of incrementally formed polycarbonate thin sheets. To this end, an experimental investigation at room temperature was conducted involving formability tests; varying wall angle cone and pyramid frusta were manufactured by processing polycarbonate sheets with different thicknesses and using tools with different diameters, in order to draw conclusions on the formability of polymer sheets through the evaluation of the forming angles and the observation of the failure mechanisms.

  13. Shifting Coronas Around Black Holes Artist Concept

    NASA Image and Video Library

    2015-10-27

    A supermassive black hole is depicted in this artist's concept, surrounded by a swirling disk of material falling onto it. The purplish ball of light above the black hole, a feature called the corona, contains highly energetic particles that generate X-ray light. If you could view the corona with your eyes, it would appear nearly invisible since we can't see its X-ray light. The corona gathers inward (left), becoming brighter, before shooting away from the black hole (middle and right). Astronomers don't know why the coronas shift, but they have learned that this process leads to a brightening of X-ray light that can be observed by telescopes. Normally, before a black hole's corona shifts, there is already an effect at work called relativistic boosting. As X-ray light from the corona reflects off the black hole's surrounding disk of material -- which is traveling near half the speed of light -- the X-ray light becomes brightened, as seen on the left side of the illustration. This boosting occurs on the side of the disk where the material is traveling toward us. The opposite effect, a dimming of the X-ray light, occurs on the other side of the disk moving away from us. Another form of relativistic boosting happens when the corona shoots away from the black hole, and later collapses. Its X-ray light is also brightened as the corona travels toward us at very fast speeds, leading to X-ray flares. In 2014, NASA's Nuclear Spectroscopic Telescope Array, or NuSTAR, and Swift space telescopes witnessed an X-flare from the supermassive black hole in a distant galaxy called Markarian 335. The observations allowed astronomers to link a shifting corona to an X-ray flare for the first time. http://photojournal.jpl.nasa.gov/catalog/PIA20051

  14. Joint Soviet-French studies of the solar corona. II - Photometry of the solar corona on June 30, 1973

    NASA Astrophysics Data System (ADS)

    Vsekhsvyatsky, S. K.; Dzyubenko, N. I.; Ivanchuk, V. I.; Popov, O. S.; Rubo, G. A.; Koutchmy, S.; Koutchmy, O.; Shtelmacher, G.

    1981-04-01

    Results are presented of a study of negatives obtained on June 30, 1973 during the total solar eclipse in Africa; the study was part of a joint Soviet-French experiment on white corona dynamics, carried out by expeditions of Kiev University (Atar, Mauritania) and the Paris Astrophysical Institute (Moussoro, Chad). The distribution of total corona brightness up to 4.5 solar radii and its K and F corona components for east and north directions were found on the basis of novel methods of photometry and colorimetry using star images up to 8.5m as the photometry standards. Neither the color effect nor flattening is found in the inner part (less than 2.5 solar radii) of the F corona. Integral corona brightness in the standard zone of 1.03-6.00 solar radii was found to be 0.64 x 10 to the -6th solar-E.

  15. Intentional formation of a protein corona on nanoparticles: Serum concentration affects protein corona mass, surface charge, and nanoparticle-cell interaction.

    PubMed

    Gräfe, Christine; Weidner, Andreas; Lühe, Moritz V D; Bergemann, Christian; Schacher, Felix H; Clement, Joachim H; Dutz, Silvio

    2016-06-01

    The protein corona, which immediately is formed after contact of nanoparticles and biological systems, plays a crucial role for the biological fate of nanoparticles. In the here presented study we describe a strategy to control the amount of corona proteins which bind on particle surface and the impact of such a protein corona on particle-cell interactions. For corona formation, polyethyleneimine (PEI) coated magnetic nanoparticles (MNP) were incubated in a medium consisting of fetal calf serum (FCS) and cell culture medium. To modulate the amount of proteins bind to particles, the composition of the incubation medium was varied with regard to the FCS content. The protein corona mass was estimated and the size distribution of the participating proteins was determined by means of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Additionally, the zeta potential of incubated particles was measured. Human blood-brain barrier-representing cell line HBMEC was used for in vitro incubation experiments. To investigate the consequences of the FCS dependent protein corona formation on the interaction of MNP and cells flow cytometry and laser scanning microscopy were used. Zeta potential as well as SDS-PAGE clearly reveal an increase in the amount of corona proteins on MNP with increasing amount of FCS in incubation medium. For MNP incubated with lower FCS concentrations especially medium-sized proteins of molecular weights between 30kDa and 100kDa could be found within the protein corona, whereas for MNP incubated within higher FCS concentrations the fraction of corona proteins of 30kDa and less increased. The presence of the protein corona reduces the interaction of PEI-coated MNP with HBMEC cells within a 30min-incubation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Ultraviolet corona detection sensor study

    NASA Technical Reports Server (NTRS)

    Schmitt, R. J.; MATHERN

    1976-01-01

    The feasibility of detecting electrical corona discharge phenomena in a space simulation chamber via emission of ultraviolet light was evaluated. A corona simulator, with a hemispherically capped point to plane electrode geometry, was used to generate corona glows over a wide range of pressure, voltage, current, electrode gap length and electrode point radius. Several ultraviolet detectors, including a copper cathode gas discharge tube and a UV enhanced silicon photodiode detector, were evaluated in the course of the spectral intensity measurements. The performance of both silicon target vidicons and silicon intensified target vidicons was evaluated analytically using the data generated by the spectroradiometer scans and the performance data supplied by the manufacturers.

  17. Protein corona - from molecular adsorption to physiological complexity.

    PubMed

    Treuel, Lennart; Docter, Dominic; Maskos, Michael; Stauber, Roland H

    2015-01-01

    In biological environments, nanoparticles are enshrouded by a layer of biomolecules, predominantly proteins, mediating its subsequent interactions with cells. Detecting this protein corona, understanding its formation with regards to nanoparticle (NP) and protein properties, and elucidating its biological implications were central aims of bio-related nano-research throughout the past years. Here, we discuss the mechanistic parameters that are involved in the protein corona formation and the consequences of this corona formation for both, the particle, and the protein. We review consequences of corona formation for colloidal stability and discuss the role of functional groups and NP surface functionalities in shaping NP-protein interactions. We also elaborate the recent advances demonstrating the strong involvement of Coulomb-type interactions between NPs and charged patches on the protein surface. Moreover, we discuss novel aspects related to the complexity of the protein corona forming under physiological conditions in full serum. Specifically, we address the relation between particle size and corona composition and the latest findings that help to shed light on temporal evolution of the full serum corona for the first time. Finally, we discuss the most recent advances regarding the molecular-scale mechanistic role of the protein corona in cellular uptake of NPs.

  18. Characteristics of pulse corona discharge over water surface

    NASA Astrophysics Data System (ADS)

    Fujii, Tomio; Arao, Yasushi; Rea, Massimo

    2008-12-01

    Production of ozone and OH radical is required to advance the plasma chemical reactions in the NOx removal processes for combustion gas treatment. The corona discharge to the water surface is expected to induce the good conditions for the proceeding of the NO oxidation and the NO2 dissolution removal into water. In order to get the fundamental data of the corona discharge over the water surface, the positive and negative V-I characteristics and the ozone production were measured with the multi needle and the saw-edge type of the discharge electrodes. The pulse corona characteristics were also measured with some different waveforms of the applied pulse voltage. The experiments were carried out under the atmospheric pressure and room temperature. Both the DC and the pulse corona to the water surface showed a stable and almost the same V-I characteristics as to plate electrodes though the surface of water was waved by corona wind. The positive streamer corona showed more ozone production than the negative one both in the DC and in the pulse corona.

  19. Olivines and olivine coronas in mesosiderites

    NASA Technical Reports Server (NTRS)

    Nehru, C. E.; Zucker, S. M.; Harlow, G. E.; Prinz, M.

    1980-01-01

    The paper presents a study of olivines and their surrounding coronas in mesosiderites texturally and compositionally using optical and microprobe methods. Olivine composition ranges from Fo(58-92) and shows no consistent pattern of distribution within and between mesosiderites; olivine occurs as large single crystals or as partially recrystallized mineral clasts, except for two lithic clasts. These are Emery and Vaca Muerta, and both are shock-modified olivine orthopyroxenites. Fine-grained coronas surround olivine, except for those in impact-melt group mesosiderites and those without tridymite in their matrices. Coronas consist largely of orthopyroxene, plagioclase, clinopyroxene, chromite, merillite, and ilmenite, and are similar to the matrix, but lack metal and tridymite. Texturally the innermost parts of the corona can be divided into three stages of development: (1) radiating acicular, (2) intermediate, and (3) granular.

  20. Close-up View of Yavine Corona

    NASA Image and Video Library

    1998-06-03

    The view from NASA's Magellan spacecraft shows Yavine Corona, looking northeast. Coronae are roughly circular, volcanic features believed to form over hot upwellings of magma within the Venusian mantle. http://photojournal.jpl.nasa.gov/catalog/PIA00098

  1. The protein corona of circulating PEGylated liposomes.

    PubMed

    Palchetti, Sara; Colapicchioni, Valentina; Digiacomo, Luca; Caracciolo, Giulio; Pozzi, Daniela; Capriotti, Anna Laura; La Barbera, Giorgia; Laganà, Aldo

    2016-02-01

    Following systemic administration, liposomes are covered by a 'corona' of proteins, and preserving the surface functionality is challenging. Coating the liposome surface with polyethylene glycol (PEG) is the most widely used anti-opsonization strategy, but it cannot fully preclude protein adsorption. To date, protein binding has been studied following in vitro incubation to predict the fate of liposomes in vivo, while dynamic incubation mimicking in vivo conditions remains largely unexplored. The main aim of this investigation was to determine whether shear stress, produced by physiologically relevant dynamic flow, could influence the liposome-protein corona. The corona of circulating PEGylated liposome was thoroughly compared with that formed by incubation in vitro. Systematic comparison in terms of size, surface charge and quantitative composition was made by dynamic light scattering, microelectrophoresis and nano-liquid chromatography tandem mass spectrometry (nanoLC-MS/MS). Size of coronas formed under static vs. dynamic incubation did not appreciably differ from each other. On the other side, the corona of circulating liposomes was more negatively charged than its static counterpart. Of note, the variety of protein species in the corona formed in a dynamic flow was significantly wider. Collectively, these results demonstrated that the corona of circulating PEGylated liposomes can be considerably different from that formed in a static fluid. This seems to be a key factor to predict the biological activity of a liposomal formulation in a physiological environment. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Global Magnetohydrodynamic Modeling of the Solar Corona

    NASA Technical Reports Server (NTRS)

    Linker, Jon A.

    1998-01-01

    The coronal magnetic field defines the structure of the solar corona, the position of the heliospheric current sheet, the regions of fast and slow solar wind, and the most likely sites of coronal mass ejections. There are few measurements of the magnetic fields in the corona, but the line-of-sight component of the global magnetic fields in the photosphere have been routinely measured for many years (for example, at Stanford's Wilcox Solar Observatory, and at the National Solar Observatory at Kitt Peak). The SOI/MDI instrument is now providing high-resolution full-disk magnetograms several times a day. Understanding the large-scale structure of the solar corona and inner heliosphere requires accurately mapping the measured photospheric magnetic field into the corona and outward. Ideally, a model should not only extrapolate the magnetic field, but should self-consistently reconstruct both the plasma and magnetic fields in the corona and solar wind. Support from our NASA SR&T contract has allowed us to develop three-dimensional magnetohydrodynamic (MHD) computations of the solar corona that incorporate observed photospheric magnetic fields into the boundary conditions. These calculations not only describe the magnetic field in the corona and interplanetary spice, but also predict the plasma properties as well. Our computations thus far have been successful in reproducing many aspects of both coronal and interplanetary data, including the structure of the streamer belt, the location of coronal hole boundaries, and the position and shape of the heliospheric current sheet. The most widely used technique for extrapolating the photospheric magnetic field into the corona and heliosphere are potential field models, such as the potential field source-surface model (PFSS),and the potential field current-sheet (PFCS) model

  3. Venus - Mosaic of Bahet and Onatah Coronae

    NASA Image and Video Library

    1996-09-26

    This mosaic of Magellan data in the Fortuna region of Venus, centered at 49 degrees north latitude, 2 degrees longitude, shows two coronae. Coronae are large circular or oval structures first identified in Soviet radar images of Venus. The structure on the left, Bahet Corona, is about 230 kilometers (138 miles) long and 150 kilometers (90 miles) across. A portion of Onatah Corona, over 350 kilometers (210 miles) in diameter, can be seen on the right of the mosaic. Both features are surrounded by a ring of ridges and troughs, which in places cut more radially-oriented fractures. The centers of the features also contain radial fractures as well as volcanic domes and flows. Coronae are thought to form due to the upwelling of hot material from deep in the interior of Venus. The two coronae may have formed at the same time over a single upwelling, or may indicate movement of the upwelling or the upper layers of the planet to the west over time. A 'pancake' dome, similar to low-relief domes see in the southern hemisphere, is located just to the southwest of Bahet. Resolution of the Magellan data is about 120 meters (400 feet). http://photojournal.jpl.nasa.gov/catalog/PIA00461

  4. Protein corona: Opportunities and challenges

    PubMed Central

    Zanganeh, Saeid; Spitler, Ryan; Erfanzadeh, Mohsen; Alkilany, Alaaldin M.; Mahmoudi, Morteza

    2017-01-01

    In contact with biological fluids diverse type of biomolecules (e.g., proteins) adsorb onto nanoparticles forming protein corona. Surface properties of the coated nanoparticles, in terms of type and amount of associated proteins, dictate their interactions with biological systems and thus biological fate, therapeutic efficiency and toxicity. In this perspective, we will focus on the recent advances and pitfalls in the protein corona field. PMID:26783938

  5. Alternating current corona discharge/atmospheric pressure chemical ionization for mass spectrometry.

    PubMed

    Habib, Ahsan; Usmanov, Dilshadbek; Ninomiya, Satoshi; Chen, Lee Chuin; Hiraoka, Kenzo

    2013-12-30

    Although alternating current (ac) corona discharge has been widely used in the fields of material science and technology, no reports have been published on its application to an atmospheric pressure chemical ionization (APCI) ion source. In this work, ac corona discharge for an APCI ion source has been examined for the first time. The ambient atmospheric pressure ac corona discharge (15 kHz, 2.6 kVptp ) was generated by using a stainless steel acupuncture needle. The generated ions were measured using an ion trap mass spectrometer. A comparative study on ac and direct current (dc) corona APCI ion sources was carried out using triacetone triperoxide and trinitrotoluene as test samples. The ac corona discharge gave ion signals as strong as dc corona discharge for both positive and negative ion modes. In addition, softer ionization was obtained with ac corona discharge than with dc corona discharge. The erosion of the needle tip induced by ac corona was less than that obtained with positive mode dc corona. A good 'yardstick' for assessing ac corona is that it can be used for both positive and negative ion modes without changing the polarity of the high-voltage power supply. Thus, ac corona can be an alternative to conventional dc corona for APCI ion sources. Copyright © 2013 John Wiley & Sons, Ltd.

  6. Pulsed Corona Discharge Generated By Marx Generator

    NASA Astrophysics Data System (ADS)

    Sretenovic, G. B.; Obradovic, B. M.; Kovacevic, V. V.; Kuraica, M. M.; Puric J.

    2010-07-01

    The pulsed plasma has a significant role in new environmental protection technologies. As a part of a pulsed corona system for pollution control applications, Marx type repetitive pulse generator was constructed and tested in arrangement with wire-plate corona reactor. We performed electrical measurements, and obtained voltage and current signals, and also power and energy delivered per pulse. Ozone formation by streamer plasma in air was chosen to monitor chemical activity of the pulsed corona discharge.

  7. Protein corona – from molecular adsorption to physiological complexity

    PubMed Central

    Docter, Dominic; Maskos, Michael

    2015-01-01

    Summary In biological environments, nanoparticles are enshrouded by a layer of biomolecules, predominantly proteins, mediating its subsequent interactions with cells. Detecting this protein corona, understanding its formation with regards to nanoparticle (NP) and protein properties, and elucidating its biological implications were central aims of bio-related nano-research throughout the past years. Here, we discuss the mechanistic parameters that are involved in the protein corona formation and the consequences of this corona formation for both, the particle, and the protein. We review consequences of corona formation for colloidal stability and discuss the role of functional groups and NP surface functionalities in shaping NP–protein interactions. We also elaborate the recent advances demonstrating the strong involvement of Coulomb-type interactions between NPs and charged patches on the protein surface. Moreover, we discuss novel aspects related to the complexity of the protein corona forming under physiological conditions in full serum. Specifically, we address the relation between particle size and corona composition and the latest findings that help to shed light on temporal evolution of the full serum corona for the first time. Finally, we discuss the most recent advances regarding the molecular-scale mechanistic role of the protein corona in cellular uptake of NPs. PMID:25977856

  8. Corona Associations and Their Implications for Venus

    USGS Publications Warehouse

    Chapman, M.G.; Zimbelman, J.R.

    1998-01-01

    Geologic mapping principles were applied to determine genetic relations between coronae and surrounding geomorphologic features within two study areas in order to better understand venusian coronae. The study areas contain coronae in a cluster versus a contrasting chain and are (1) directly west of Phoebe Regio (quadrangle V-40; centered at latitude 15??S, longitude 250??) and (2) west of Asteria and Beta Regiones (between latitude 23??N, longitude 239?? and latitude 43??N, longitude 275??). Results of this research indicate two groups of coronae on Venus: (1) those that are older and nearly coeval with regional plains, and occur globally; and (2) those that are younger and occur between Beta, Atla, and Themis Regiones or along extensional rifts elsewhere, sometimes showing systematic age progressions. Mapping relations and Earth analogs suggest that older plains coronae may be related to a near-global resurfacing event perhaps initiated by a mantle superplume or plumes. Younger coronae of this study that show age progression may be related to (1) a tectonic junction of connecting rifts resulting from local mantle upwelling and spread of a quasi-stationary hotspot plume, and (2) localized spread of post-plains volcanism. We postulate that on Venus most of the young, post-resurfacing coronal plumes may be concentrated within an area defined by the bounds of Beta, Atla, and Themis Regiones. ?? 1998 Academic Press.

  9. Line transients with corona

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Saied, M.M.; Safar, Y.A.; Salama, M.H.

    1987-01-01

    This paper investigates the effect of corona on the electromagnetic transients along high voltage overhead lines. A method is presented to simulate the line by dividing it into a number of sections connected in cascade. For {ital n} line sections, the number of the unknown variables is 2{ital n} + 1. The method allows any waveform of the exciting voltage function, as well as any impedance loading condition. The corona is represented by voltage-dependent shunt current sources. A systematic way for writing a sufficient number of differential equations is shown. For their solution, a digital computer subroutine based on themore » Runge--Kutta--Verner method was used. An artificial frequency-dependent damping by means of linear resistors was used to suppress the Gibb's oscillations in the solution. The proposed method is applied to study the transients on a 40 km high voltage line with 30-ft flat phase spacing and a single 1.4 inch ACSR conductor per phase. The exciting voltage has a double-exponential impulse waveform. Solutions are given for three values of resistive loads Z{sub {ital c}}2Z{sub {ital c}} and Z{sub {ital c}}/2, where Z{sub {ital c}} is the line surge impedance. The results of two interesting cases of inductive and capacitive loads are also given. Physical interpretations for the different solutions are given. Also, the current-voltage duality between inductive and capacitive loads is recognized. The corona was found to attenuate and distort the travelling waves. For example, during one wave excursion, the reduction of the current wave peaks can reach values as high as 8.5%. The effect is more noticeable in the current than in the voltage waves. As expected, it increases also with the line corona losses. The effect of the increase of the line effective capacitance due to the corona discharge is also demonstrated.« less

  10. System for increasing corona inception voltage of insulating oils

    DOEpatents

    Rohwein, Gerald J.

    1998-01-01

    The Corona Inception Voltage of insulating oils is increased by repetitive cycles of prestressing the oil with a voltage greater than the corona inception voltage, and either simultaneously or serially removing byproducts of corona by evacuation and heating the oil.

  11. Understanding the Kinetics of Protein-Nanoparticle Corona Formation.

    PubMed

    Vilanova, Oriol; Mittag, Judith J; Kelly, Philip M; Milani, Silvia; Dawson, Kenneth A; Rädler, Joachim O; Franzese, Giancarlo

    2016-12-27

    When a pristine nanoparticle (NP) encounters a biological fluid, biomolecules spontaneously form adsorption layers around the NP, called "protein corona". The corona composition depends on the time-dependent environmental conditions and determines the NP's fate within living organisms. Understanding how the corona evolves is fundamental in nanotoxicology as well as medical applications. However, the process of corona formation is challenging due to the large number of molecules involved and to the large span of relevant time scales ranging from 100 μs, hard to probe in experiments, to hours, out of reach of all-atoms simulations. Here we combine experiments, simulations, and theory to study (i) the corona kinetics (over 10 -3 -10 3 s) and (ii) its final composition for silica NPs in a model plasma made of three blood proteins (human serum albumin, transferrin, and fibrinogen). When computer simulations are calibrated by experimental protein-NP binding affinities measured in single-protein solutions, the theoretical model correctly reproduces competitive protein replacement as proven by independent experiments. When we change the order of administration of the three proteins, we observe a memory effect in the final corona composition that we can explain within our model. Our combined experimental and computational approach is a step toward the development of systematic prediction and control of protein-NP corona composition based on a hierarchy of equilibrium protein binding constants.

  12. System for increasing corona inception voltage of insulating oils

    DOEpatents

    Rohwein, G.J.

    1998-05-19

    The Corona Inception Voltage of insulating oils is increased by repetitive cycles of prestressing the oil with a voltage greater than the corona inception voltage, and either simultaneously or serially removing byproducts of corona by evacuation and heating the oil. 5 figs.

  13. Transient corona effects on a wire over the ground

    NASA Technical Reports Server (NTRS)

    Chen, K. C.

    1980-01-01

    The nuclear EMP effect on VLF/trailing wire antennas is investigated in relation to new features of corona effects. Previous experimental results on transmission lines with corona under E 80 kV/cm recorded in the nanosecond time frame are analyzed. A nonlinear macroscopic model which describes a transmission line with corona is discussed. The model not only accounts for overall waveform, but also describes the sharp changes in the waveform associated with the corona onset.

  14. Iridescent clouds and distorted coronas.

    PubMed

    Laven, Philip

    2017-07-01

    Near-forward scattering of sunlight generates coronas and iridescence on clouds. Coronas are caused by diffraction, whereas iridescence is less easily explained. Iridescence often appears as bands of color aligned with the edges of clouds or as apparently random patches of color on clouds. This paper suggests that iridescence is due to interference between light that has been diffracted by a spherical droplet of water and light that has been transmitted through the same droplet.

  15. Personalized protein corona on nanoparticles and its clinical implications.

    PubMed

    Corbo, Claudia; Molinaro, Roberto; Tabatabaei, Mateen; Farokhzad, Omid C; Mahmoudi, Morteza

    2017-02-28

    It is now well understood that once in contact with biological fluids, nanoscale objects lose their original identity and acquire a new biological character, referred to as a protein corona. The protein corona changes many of the physicochemical properties of nanoparticles, including size, surface charge, and aggregation state. These changes, in turn, affect the biological fate of nanoparticles, including their pharmacokinetics, biodistribution, and therapeutic efficacy. It is progressively being accepted that even slight variations in the composition of a protein source (e.g., plasma and serum) can substantially change the composition of the corona formed on the surface of the exact same nanoparticles. Recently it has been shown that the protein corona is strongly affected by the patient's specific disease. Therefore, the same nanomaterial incubated with plasma proteins of patients with different pathologies adsorb protein coronas with different compositions, giving rise to the concept of personalized protein corona. Herein, we review this concept along with recent advances on the topic, with a particular focus on clinical relevance.

  16. System reliability analysis through corona testing

    NASA Technical Reports Server (NTRS)

    Lalli, V. R.; Mueller, L. A.; Koutnik, E. A.

    1975-01-01

    A corona vacuum test facility for nondestructive testing of power system components was built in the Reliability and Quality Engineering Test Laboratories at the NASA Lewis Research Center. The facility was developed to simulate operating temperature and vacuum while monitoring corona discharges with residual gases. The facility is being used to test various high-voltage power system components.

  17. Electromagnetic Radiation from Corona Discharges.

    DTIC Science & Technology

    1977-01-25

    a 3 MHz bandwidth to cover frequencies below I GHz. Various TWT preamplifiers were used to increase the system gain. R-f energy from the corona point...100 MHz CENTER FREQUENCYr 0.05 mv/div 5 ps/div FIGURE 11. DETECTED I.F SIGNALS RECEIVED FROM A 20’ PIPE IN CORONA 29 the broadband impulsive background...noise at sea, with a secondary objective of measuring background noise at narrower bandwidths on a swept frequency basis. The broadband measurement

  18. Admittance Survey of Type 1 Coronae on Venus: Implications for Elastic Thickness

    NASA Technical Reports Server (NTRS)

    Hoogenboom, T.; Smrekar, S. E.; Anderson, F. S.; Houseman, G.

    2003-01-01

    Coronae are volcano-tectonic features on Venus which range from 60km to 2600km and are defined by their nearly circular patterns of fractures. Type 1 (regular) coronae are classified as having >50% complete fracture annuli. Previous work has examined the factors controlling the morphology, size, and fracture pattern of coronae, using lithospheric properties, loading signature and geologic characteristics. However, these studies have been limited to Type 2 (topographic) coronae (e.g. coronaes with <50% fracture annuli), and the factors controlling the formation of Type 1 coronae remain poorly understood. In this study, we apply the methodology of to survey the admittance signature for Type 1 coronae to determine the controlling parameters which govern Type 1 coronae formation.

  19. System reliability analysis through corona testing

    NASA Technical Reports Server (NTRS)

    Lalli, V. R.; Mueller, L. A.; Koutnik, E. A.

    1975-01-01

    In the Reliability and Quality Engineering Test Laboratory at the NASA Lewis Research Center a nondestructive, corona-vacuum test facility for testing power system components was developed using commercially available hardware. The test facility was developed to simulate operating temperature and vacuum while monitoring corona discharges with residual gases. This facility is being used to test various high voltage power system components.

  20. Influence of humidity on the characteristics of positive corona discharge in air

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xu, Pengfei, E-mail: xpftsh@126.com; Zhang, Bo, E-mail: shizbcn@mail.tsinghua.edu.cn; Chen, Shuiming, E-mail: chensm@tsinghua.edu.cn

    Detailed positive corona discharge characteristics, such as the corona onset voltage, pulse amplitude, repetition frequency, average corona current, rise time, and half-wave time, are systematically studied under different air humidity with a single artificial defect electrode. The experimental results indicate that the pulse amplitude decreases with the increase of air humidity; meanwhile, the repetition frequency increases as the air humidity increases. This phenomenon is different from that of negative corona discharge. Therefore, to have an insight into the mechanism of humidity influence on positive corona discharge, a positive corona discharge model based on the continuity equations is utilized. The simulationsmore » present a dynamic development of positive corona discharge and, meanwhile, reveal the humidity influence on positive corona discharge.« less

  1. Comparison of Topographic Profiles Across Venus' Coronae and Craters: Implications for Corona Origin Hypothesis

    NASA Astrophysics Data System (ADS)

    Stoddard, P. R.; Jurdy, D. M.

    2006-12-01

    Venus' surface hosts nearly 1000 unambiguous impact craters, ranging in diameter from 1.5 to 280 km. Although the majority of these are pristine, slightly less than 200 have been modified by either volcanic or tectonic activity or both. In addition, numerous researchers have identified hundreds of ring-like features of varying morphology, termed "coronae." These have typically been thought of as having a diapiric or volcanic origin. Recently, however, based on the circular to quasi-circular nature of coronae, an alternative origin - impact - has been proposed. We compare the profiles across agreed-upon craters to several coronae that have been suggested as impact sites. For each feature, 36 profiles (taken every ten degrees) are aligned and then averaged together. For Mead, Cleopatra, Meitner, and Isabella craters, the profiles display the typical rim and basin structure expected for craters, but for Klenova crater the average is more domal, with only a few of the individual profiles looking crater-like. Among the "contested" coronae, the average profiles for Eurynome, Maya, and C21 appear crater-like, albeit with more variation among the individual profiles than seen in the agreed-upon craters. Anquet has a rim-and-basin structure, but unlike typical craters, the basin is elevated above the surrounding plains. Acrea appears to be a small hill in a large depression, again with a high degree of variability among the profiles. Ninhursag is clearly domal, and cannot be taken as a crater. A summary of the variability of the profiles - where 100% correlation would indicate perfect circular symmetry - indicates that, with the exception of Klenova, those features universally agreed-upon as craters have the highest correlation percentages - all at or above 80%. The disputed features are not as circular, although C21 is close. Based on this analysis, we conclude that Klenova has been mischaracterized as an impact crater, and that C21 and some other features previously

  2. Translating Current Bioanalytical Techniques for Studying Corona Activity.

    PubMed

    Wang, Chunming; Wang, Zhenzhen; Dong, Lei

    2018-07-01

    The recent discovery of the biological corona is revolutionising our understanding of the in vivo behaviour of nanomaterials. Accurate analysis of corona bioactivity is essential for predicting the fate of nanomaterials and thereby improving nanomedicine design. Nevertheless, current biotechniques for protein analysis are not readily adaptable for analysing corona proteins, given that their conformation, activity, and interaction may largely differ from those of the native proteins. Here, we introduce and propose tailor-made modifications to five types of mainstream bioanalytical methodologies. We specifically illustrate how these modifications can translate existing techniques for protein analysis into competent tools for dissecting the composition, bioactivity, and interaction (with both nanomaterials and the tissue) of corona formed on specific nanomaterial surfaces. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Acoustic waves in M dwarfs: Maintaining a corona

    NASA Technical Reports Server (NTRS)

    Mullan, D. J.; Cheng, Q. Q.

    1994-01-01

    We use a time-dependent hydrodynamics code to follow the propagation of acoustic waves into the corona of an M dwarf star. An important qualitative difference between M dwarfs and stars such as the Sun is that the acoustic spectrum in M dwarfs is expected to peak at periods close to the acoustic cutoff P(sub A): this allows more effective penetration of waves into the corona. In our code, radiative losses in the photosphere, chromosphere, and corona are computed using Rosseland mean opacities, Mg II kappa and Ly alpha emission, and optically thin emissivities respectively. We find that acoustic heating can maintain a corona with a temperature of order 0.7-1 x 10(exp 6) K and a surface X-ray flux as large as 10(exp 5)ergs/sq cm/s. In a recent survey of X-rays from M dwarfs, some (20%-30%) of the stars lie at or below this limiting X-ray flux: we suggest that such stars may be candidates for acoustically maintained coronae.

  4. Space matters: meristem expansion triggers corona formation in Passiflora

    PubMed Central

    Claßen-Bockhoff, Regine; Meyer, Charlotte

    2016-01-01

    Background and aims Flower meristems differ from vegetative meristems in various aspects. One characteristic is the capacity for ongoing meristem expansion providing space for new structures. Here, corona formation in four species of Passiflora is investigated to understand the spatio-temporal conditions of its formation and to clarify homology of the corona elements. Methods One bird-pollinated species with a single-rowed tubular corona (Passiflora tulae) and three insect-pollinated species with three (P. standleyi Killip), four (P. foetida L. ‘Sanctae Martae’) and six (P. foetida L. var. hispida) ray-shaped corona rows are chosen as representative examples for the study. Flower development is documented by scanning electron microscopy. Meristem expansion is reconstructed by morphometric data and correlated with the sequential corona element formation. Key Results In all species, corona formation starts late in ontogeny after all floral organs have been initiated. It is closely correlated with meristem expansion. The rows appear with increasing space in centripetal or convergent sequence. Conclusions Based on the concept of fractionation, space induces primordia formation which is a self-regulating process filling the space completely. Correspondingly, the corona is interpreted as a structure of its own, originating from the receptacle. Considering the principle capacity of flower meristems to generate novel structures widens the view and allows new interpretations in combination with molecular, phylogenetic and morphogenetic data. PMID:26658486

  5. Constraints on Lithospheric Rheology from Observations of Coronae on Venus

    NASA Astrophysics Data System (ADS)

    O'Rourke, Joseph G.; Smrekar, Suzanne; Moresi, Louis N.

    2016-10-01

    Coronae are enigmatic, quasi-circular features found in myriad geological environments. They are primarily distinguished as rings of concentric fractures superimposed on various topographic profiles with at least small-scale volcanism. Mantle plumes may produce coronae with interior rises, whereas coronae with central depressions are often attributed to downwellings like Rayleigh-Taylor instabilities. For almost three decades, modelers have attempted to reproduce the topographic and gravity profiles measured at coronae. Until recently, few studies also considered tectonic deformation and melt production. In particular, "Type 2" coronae have complete topographic rims but arcs of fractures extending less than 180°, signifying both brittle and ductile deformation. Only a narrow range of rheological parameters like temperature and volatile content may be compatible with these observations. Ultimately, identifying how lithospheric properties differ between Earth and Venus is critical to understanding what factors permit plate tectonics on rocky, Earth-sized planets.Here we present a hierarchical approach to study the formation of coronae. First, we discuss an observational survey enabled by a new digital elevation model derived from stereo topography for ~20% of the surface of Venus, which offers an order-of-magnitude improvement over the horizontal resolution (10 to 20 kilometers) of altimetry data from NASA's Magellan mission. Next, we search this new dataset for signs of lithospheric flexure around small coronae. Simple, thin-elastic plate models were fit to topographic profiles of larger coronae in previous studies, but data resolution impeded efforts to apply this method to the entire coronae population. Finally, we show simulations of the formation of coronae using Underworld II, an open-source code adaptable to a variety of geodynamical problems. We benchmark our code using models of pure Rayleigh-Taylor instabilities and then investigate the influence of

  6. Corona Preionization Technique for Carbon Dioxide TEA Lasers.

    DTIC Science & Technology

    1982-11-30

    34’" " " " "- -. .. " "I~ 82R8O701-02 CORONA PREIONIZATION TECHNIQUE FOR CARBON DIOXIDE TEA LASERS W after R. Kamnki SUnited Technologiles Research Center C...TITLE (and Subtitle) S. TYPE OF REPORT a PERIOD COVERED CORONA PREIONIZATION TECHNIQUE FOR CARBON Final Report DIOXIDE TEA LASERS May 5, 1981...Preionization Laser UV Preionization Pulsed CO2 Laser Corona Preionization CO2 TEA Laser 10. ABSTRACT (Continue on reverse side If neceeeiny md Identify

  7. Nanoparticle-protein complexes mimicking corona formation in ocular environment.

    PubMed

    Jo, Dong Hyun; Kim, Jin Hyoung; Son, Jin Gyeong; Dan, Ki Soon; Song, Sang Hoon; Lee, Tae Geol; Kim, Jeong Hun

    2016-12-01

    Nanoparticles adsorb biomolecules to form corona upon entering the biological environment. In this study, tissue-specific corona formation is provided as a way of controlling protein interaction with nanoparticles in vivo. In the vitreous, the composition of the corona was determined by the electrostatic and hydrophobic properties of the associated proteins, regardless of the material (gold and silica) or size (20- and 100-nm diameter) of the nanoparticles. To control protein adsorption, we pre-incubate 20-nm gold nanoparticles with 5 selectively enriched proteins from the corona, formed in the vitreous, to produce nanoparticle-protein complexes. Compared to bare nanoparticles, nanoparticle-protein complexes demonstrate improved binding to vascular endothelial growth factor (VEGF) in the vitreous. Furthermore, nanoparticle-protein complexes retain in vitro anti-angiogenic properties of bare nanoparticles. In particular, priming the nanoparticles (gold and silica) with tissue-specific corona proteins allows nanoparticle-protein complexes to exert better in vivo therapeutic effects by higher binding to VEGF than bare nanoparticles. These results suggest that controlled corona formation that mimics in vivo processes may be useful in the therapeutic use of nanomaterials in local environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Kinetics of the formation of a protein corona around nanoparticles.

    PubMed

    Zhdanov, Vladimir P; Cho, Nam-Joon

    2016-12-01

    Interaction of metal or oxide nanoparticles (NPs) with biological soft matter is one of the central phenomena in basic and applied biology-oriented nanoscience. Often, this interaction includes adsorption of suspended proteins on the NP surface, resulting in the formation of the protein corona around NPs. Structurally, the corona contains a "hard" monolayer shell directly contacting a NP and a more distant weakly associated "soft" shell. Chemically, the corona is typically composed of a mixture of distinct proteins. The corresponding experimental and theoretical studies have already clarified many aspects of the corona formation. The process is, however, complex, and its understanding is still incomplete. Herein, we present a kinetic mean-field model of the formation of the "hard" corona with emphasis on the role of (i) protein-diffusion limitations and (ii) interplay between competitive adsorption of distinct proteins and irreversible reconfiguration of their native structure. The former factor is demonstrated to be significant only in the very beginning of the corona formation. The latter factor is predicted to be more important. It may determine the composition of the corona on the time scales comparable or longer than a few hours. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. The solar radio corona: Manifestations of energetic electrons

    NASA Technical Reports Server (NTRS)

    Pick, M.

    1986-01-01

    Radio observations are powerful tools which are complementary to the space missions devoted to the physics of the flares, of the corona, or of the interplanetary medium. To undertake this task two multifrequency radioheliographs presently exist: the Nancay instrument (the multifrequency facility will be in operation by the end of 1985) observes the middle corona at decimeter-meter wavelengths, and the Clark Lake radioheliograph, operating at decameter wavelengths, is the only one in the world to have the ability of observing the outer corona above the disk.

  10. Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona.

    PubMed

    Feiner-Gracia, Natalia; Beck, Michaela; Pujals, Sílvia; Tosi, Sébastien; Mandal, Tamoghna; Buske, Christian; Linden, Mika; Albertazzi, Lorenzo

    2017-11-01

    The adsorption of serum proteins, leading to the formation of a biomolecular corona, is a key determinant of the biological identity of nanoparticles in vivo. Therefore, gaining knowledge on the formation, composition, and temporal evolution of the corona is of utmost importance for the development of nanoparticle-based therapies. Here, it is shown that the use of super-resolution optical microscopy enables the imaging of the protein corona on mesoporous silica nanoparticles with single protein sensitivity. Particle-by-particle quantification reveals a significant heterogeneity in protein absorption under native conditions. Moreover, the diversity of the corona evolves over time depending on the surface chemistry and degradability of the particles. This paper investigates the consequences of protein adsorption for specific cell targeting by antibody-functionalized nanoparticles providing a detailed understanding of corona-activity relations. The methodology is widely applicable to a variety of nanostructures and complements the existing ensemble approaches for protein corona study. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Space matters: meristem expansion triggers corona formation in Passiflora.

    PubMed

    Claßen-Bockhoff, Regine; Meyer, Charlotte

    2016-02-01

    Flower meristems differ from vegetative meristems in various aspects. One characteristic is the capacity for ongoing meristem expansion providing space for new structures. Here, corona formation in four species of Passiflora is investigated to understand the spatio-temporal conditions of its formation and to clarify homology of the corona elements. One bird-pollinated species with a single-rowed tubular corona (Passiflora tulae) and three insect-pollinated species with three (P. standleyi Killip), four (P. foetida L. 'Sanctae Martae') and six (P. foetida L. var. hispida) ray-shaped corona rows are chosen as representative examples for the study. Flower development is documented by scanning electron microscopy. Meristem expansion is reconstructed by morphometric data and correlated with the sequential corona element formation. In all species, corona formation starts late in ontogeny after all floral organs have been initiated. It is closely correlated with meristem expansion. The rows appear with increasing space in centripetal or convergent sequence. Based on the concept of fractionation, space induces primordia formation which is a self-regulating process filling the space completely. Correspondingly, the corona is interpreted as a structure of its own, originating from the receptacle. Considering the principle capacity of flower meristems to generate novel structures widens the view and allows new interpretations in combination with molecular, phylogenetic and morphogenetic data. © The Author 2015. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  12. Corona discharges from a windmill and its lightning protection tower in winter thunderstorms

    NASA Astrophysics Data System (ADS)

    Wu, Ting; Wang, Daohong; Rison, William; Thomas, Ronald J.; Edens, Harald E.; Takagi, Nobuyuki; Krehbiel, Paul R.

    2017-05-01

    This paper presents lightning mapping array (LMA) observations of corona discharges from a windmill and its lightning protection tower in winter thunderstorms in Japan. Corona discharges from the windmill, called windmill coronas, and those from the tower, called tower coronas, are distinctly different. Windmill coronas occur with periodic bursts, generally radiate larger power, and possibly develop to higher altitudes than tower coronas do. A strong negative electric field is necessary for the frequent production of tower coronas but is not apparently related with windmill coronas. These differences are due to the periodic rotation of the windmill and the moving blades which can escape space charges produced by corona discharges and sustain a large local electric field. The production period of windmill coronas is related with the rotation period of the windmill. Surprisingly, for one rotation of the windmill, only two out of the three blades produce detectable discharges and source powers of discharges from these two blades are different. The reason for this phenomenon is still unclear. For tower coronas, the source rate can get very high only when there is a strong negative electric field, and the source power can get very high only when the source rate is very low. The relationship between corona discharges and lightning flashes is investigated. There is no direct evidence that corona discharges can increase the chance of upward leader initiation, but nearby lightning flashes can increase the source rate of corona discharges right after the flashes. The peak of the source height distribution of corona discharges is about 100 m higher than the top of the windmill and the top of the tower. Possible reasons for this result are discussed.

  13. The TESIS experiment on the CORONAS-PHOTON spacecraft

    NASA Astrophysics Data System (ADS)

    Kuzin, S. V.; Zhitnik, I. A.; Shestov, S. V.; Bogachev, S. A.; Bugaenko, O. I.; Ignat'ev, A. P.; Pertsov, A. A.; Ulyanov, A. S.; Reva, A. A.; Slemzin, V. A.; Sukhodrev, N. K.; Ivanov, Yu. S.; Goncharov, L. A.; Mitrofanov, A. V.; Popov, S. G.; Shergina, T. A.; Solov'ev, V. A.; Oparin, S. N.; Zykov, A. M.

    2011-04-01

    On February 26, 2009, the first data was obtained in the TESIS experiment on the research of the solar corona using imaging spectroscopy. The TESIS is a part of the scientific equipment of the CORONAS-PHO-TON spacecraft and is designed for imaging the solar corona in soft X-ray and extreme ultraviolet regions of the spectrum with high spatial, spectral, and temporal resolutions at altitudes from the transition region to three solar radii. The article describes the main characteristics of the instrumentation, management features, and operation modes.

  14. Pulsed corona generation using a diode-based pulsed power generator

    NASA Astrophysics Data System (ADS)

    Pemen, A. J. M.; Grekhov, I. V.; van Heesch, E. J. M.; Yan, K.; Nair, S. A.; Korotkov, S. V.

    2003-10-01

    Pulsed plasma techniques serve a wide range of unconventional processes, such as gas and water processing, hydrogen production, and nanotechnology. Extending research on promising applications, such as pulsed corona processing, depends to a great extent on the availability of reliable, efficient and repetitive high-voltage pulsed power technology. Heavy-duty opening switches are the most critical components in high-voltage pulsed power systems with inductive energy storage. At the Ioffe Institute, an unconventional switching mechanism has been found, based on the fast recovery process in a diode. This article discusses the application of such a "drift-step-recovery-diode" for pulsed corona plasma generation. The principle of the diode-based nanosecond high-voltage generator will be discussed. The generator will be coupled to a corona reactor via a transmission-line transformer. The advantages of this concept, such as easy voltage transformation, load matching, switch protection and easy coupling with a dc bias voltage, will be discussed. The developed circuit is tested at both a resistive load and various corona reactors. Methods to optimize the energy transfer to a corona reactor have been evaluated. The impedance matching between the pulse generator and corona reactor can be significantly improved by using a dc bias voltage. At good matching, the corona energy increases and less energy reflects back to the generator. Matching can also be slightly improved by increasing the temperature in the corona reactor. More effective is to reduce the reactor pressure.

  15. Recycling of the Solar Corona's Magnetic Field

    NASA Astrophysics Data System (ADS)

    Close, R. M.; Parnell, C. E.; Longcope, D. W.; Priest, E. R.

    2004-09-01

    Magnetic fields play a dominant role in the atmospheres of the Sun and other Sun-like stars. Outside sunspot regions, the photosphere of the so-called quiet Sun contains myriads of small-scale magnetic concentrations, with strengths ranging from the detection limit of ~1016 Mx up to ~3×1020 Mx. The tireless motion of these magnetic flux concentrations, along with the continual appearance and disappearance of opposite-polarity pairs of fluxes, releases a substantial amount of energy that may be associated with a whole host of physical processes in the solar corona, not least the enigma of coronal heating. We find here that the timescale for magnetic flux to be remapped in the quiet-Sun corona is, surprisingly, only 1.4 hr (around 1/10 of the photospheric flux recycling time), implying that the quiet-Sun corona is far more dynamic than previously thought. Besides leading to a fuller understanding of the origins of magnetically driven phenomena in our Sun's corona, such a process may also be crucial for the understanding of stellar atmospheres in general.

  16. Miniature Dual-Corona Ionizer for Bipolar Charging of Aerosol

    PubMed Central

    Qi, Chaolong; Kulkarni, Pramod

    2015-01-01

    A corona-based bipolar charger has been developed for use in compact, field-portable mobility size spectrometers. The charger employs an aerosol flow cavity exposed to two corona ionizers producing ions of opposite polarity. Each corona ionizer houses two electrodes in parallel needle-mesh configuration and is operated at the same magnitude of corona current. Experimental measurement of detailed charge distribution of near-monodisperse particles of different diameter in the submicrometer size range showed that the charger is capable of producing well-defined, consistent bipolar charge distributions for flow rates up to 1.5 L/min and aerosol concentration up to 107 per cm3. For particles with preexisting charge of +1, 0, and −1, the measured charge distributions agreed well with the theoretical distributions within the range of experimental and theoretical uncertainties. The transmission efficiency of the charger was measured to be 80% for 10 nm particles (at 0.3 L/min and 5 μA corona current) and increased with increasing diameter beyond this size. Measurement of uncharged fractions at various combinations of positive and negative corona currents showed the charger performance to be insensitive to fluctuations in corona current. Ion concentrations under positive and negative unipolar operation were estimated to be 8.2 × 107 and 3.37 × 108 cm−3 for positive and negative ions; the n·t product value under positive corona operation was independently estimated to be 8.5 × 105 s/cm3. The ion concentration estimates indicate the charger to be capable of “neutralizing” typical atmospheric and industrial aerosols in most measurement applications. The miniature size, simple and robust operation makes the charger suitable for portable mobility spectrometers. PMID:26512158

  17. Miniature Dual-Corona Ionizer for Bipolar Charging of Aerosol.

    PubMed

    Qi, Chaolong; Kulkarni, Pramod

    2013-01-01

    A corona-based bipolar charger has been developed for use in compact, field-portable mobility size spectrometers. The charger employs an aerosol flow cavity exposed to two corona ionizers producing ions of opposite polarity. Each corona ionizer houses two electrodes in parallel needle-mesh configuration and is operated at the same magnitude of corona current. Experimental measurement of detailed charge distribution of near-monodisperse particles of different diameter in the submicrometer size range showed that the charger is capable of producing well-defined, consistent bipolar charge distributions for flow rates up to 1.5 L/min and aerosol concentration up to 10 7 per cm 3 . For particles with preexisting charge of +1, 0, and -1, the measured charge distributions agreed well with the theoretical distributions within the range of experimental and theoretical uncertainties. The transmission efficiency of the charger was measured to be 80% for 10 nm particles (at 0.3 L/min and 5 μ A corona current) and increased with increasing diameter beyond this size. Measurement of uncharged fractions at various combinations of positive and negative corona currents showed the charger performance to be insensitive to fluctuations in corona current. Ion concentrations under positive and negative unipolar operation were estimated to be 8.2 × 10 7 and 3.37 × 10 8 cm -3 for positive and negative ions; the n · t product value under positive corona operation was independently estimated to be 8.5 × 10 5 s/cm 3 . The ion concentration estimates indicate the charger to be capable of "neutralizing" typical atmospheric and industrial aerosols in most measurement applications. The miniature size, simple and robust operation makes the charger suitable for portable mobility spectrometers.

  18. Exploring the prominence-corona connection and its expansion into the outer corona using total solar eclipse observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Habbal, Shadia Rifai; Morgan, Huw; Druckmüller, Miloslav, E-mail: shadia@ifa.hawaii.edu

    Prominences constitute the most complex magnetic structures in the solar corona. The ubiquitous presence of their seemingly confined dense and cool plasma in an otherwise million-degree environment remains a puzzle. Using a decade of white light total solar eclipse observations, we show how these images reveal an intricate relationship between prominences and coronal structures both in their immediate vicinity, known as coronal cavities, and in the extended corona out to several solar radii. Observations of suspended prominences and twisted helical structures spanning several solar radii are central to these findings. The different manifestations of the prominence-corona interface that emerge frommore » this study underscore the fundamental role played by prominences in defining and controlling the complex expansion and dynamic behavior of the solar magnetic field in the neighborhood of magnetic polarity reversal regions. This study suggests that the unraveling of prominences and the outward expansion of the helical twisted field lines linked to them could be the solar origin of twisted magnetic flux ropes detected in interplanetary space, and of the mechanism by which the Sun sheds its magnetic helicity. This work also underscores the likely role of the prominence-corona interface as a source of the slow solar wind.« less

  19. Electrophysiological diagnosis and patterns of response to treatment of botulism with neuromuscular respiratory failure.

    PubMed

    Kongsaengdao, Subsai; Samintarapanya, Kanoksri; Rusmeechan, Siwarit; Sithinamsuwan, Pasiri; Tanprawate, Surat

    2009-08-01

    In this study we describe the electrophysiological findings in botulism patients with neuromuscular respiratory failure from major botulism outbreaks in Thailand. High-rate repetitive nerve stimulation testing (RNST) of the abductor digiti minimi (ADM) muscle of 17 botulism patients with neuromuscular respiratory failure showed mostly incremental responses, especially in response to >20-HZ stimulation. In the most severe stage of neuromuscular respiratory failure, RNST failed to elicit a compound muscle action potential (CMAP) of the ADM muscle. In the moderately severe stage, the initial CMAPs were of very low amplitude, and a 3-HZ RNST elicited incremental or decremental responses. A 10-HZ RNST elicited mainly decremental responses. In the early recovery stage, the initial CMAP amplitudes of the ADM muscle improved, with initially low amplitudes and an incremental response to 3- and 10-HZ RNSTs. Improved electrophysiological patterns of the ADM muscle correlated with improved respiratory muscle function. Incremental responses to 20-HZ RNST were most useful for diagnosis. The initial electrodiagnostic sign of recovery following treatment of neuromuscular respiratory failure was an increased CMAP amplitude and an incremental response to 10-20-HZ RNST. Muscle Nerve 40: 271-278, 2009.

  20. Direct observation of a single nanoparticle-ubiquitin corona formation

    NASA Astrophysics Data System (ADS)

    Ding, Feng; Radic, Slaven; Chen, Ran; Chen, Pengyu; Geitner, Nicholas K.; Brown, Jared M.; Ke, Pu Chun

    2013-09-01

    The advancement of nanomedicine and the increasing applications of nanoparticles in consumer products have led to administered biological exposure and unintentional environmental accumulation of nanoparticles, causing concerns over the biocompatibility and sustainability of nanotechnology. Upon entering physiological environments, nanoparticles readily assume the form of a nanoparticle-protein corona that dictates their biological identity. Consequently, understanding the structure and dynamics of a nanoparticle-protein corona is essential for predicting the fate, transport, and toxicity of nanomaterials in living systems and for enabling the vast applications of nanomedicine. Here we combined multiscale molecular dynamics simulations and complementary experiments to characterize the silver nanoparticle-ubiquitin corona formation. Notably, ubiquitins competed with citrates for the nanoparticle surface, governed by specific electrostatic interactions. Under a high protein/nanoparticle stoichiometry, ubiquitins formed a multi-layer corona on the particle surface. The binding exhibited an unusual stretched-exponential behavior, suggesting a rich binding kinetics. Furthermore, the binding destabilized the α-helices while increasing the β-sheet content of the proteins. This study revealed the atomic and molecular details of the structural and dynamic characteristics of nanoparticle-protein corona formation.The advancement of nanomedicine and the increasing applications of nanoparticles in consumer products have led to administered biological exposure and unintentional environmental accumulation of nanoparticles, causing concerns over the biocompatibility and sustainability of nanotechnology. Upon entering physiological environments, nanoparticles readily assume the form of a nanoparticle-protein corona that dictates their biological identity. Consequently, understanding the structure and dynamics of a nanoparticle-protein corona is essential for predicting the fate

  1. Elastic Thickness Estimates for Coronae Associated with Chasmata on Venus

    NASA Technical Reports Server (NTRS)

    Hoogenboom, T.; Martin, P.; Housean, G. A.

    2005-01-01

    Coronae are large-scale circular tectonic features surrounded by annular ridges. They are generally considered unique to Venus and may offer insights into the differences in lithospheric structure or mantle convective pattern between Venus and Earth. 68% of all coronae are associated with chasmata or fracture belts. The remaining 32% are located at volcanic rises or in the plains. Chasmata are linear to arcuate troughs, with trough parallel fractures and faults which extend for 1000 s of kilometers. Estimates of the elastic thickness of the lithosphere (T(sub e)) have been calculated in a number of gravity/topography studies of Venus and for coronae specifically. None of these studies, however, have explored the dependence of T(sub e) on the tectonic history of the region, as implied from the interpretation of relative timing relationships between coronae and surrounding features. We examine the relationship between the local T(sub e) and the relative ages of coronae and chasmata with the aim of further constraining the origin and evolution of coronae and chasmata systems.

  2. Protein bio-corona: critical issue in immune nanotoxicology.

    PubMed

    Neagu, Monica; Piperigkou, Zoi; Karamanou, Konstantina; Engin, Ayse Basak; Docea, Anca Oana; Constantin, Carolina; Negrei, Carolina; Nikitovic, Dragana; Tsatsakis, Aristidis

    2017-03-01

    With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein "bio-corona." The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle's physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.

  3. Surfactant titration of nanoparticle-protein corona.

    PubMed

    Maiolo, Daniele; Bergese, Paolo; Mahon, Eugene; Dawson, Kenneth A; Monopoli, Marco P

    2014-12-16

    Nanoparticles (NP), when exposed to biological fluids, are coated by specific proteins that form the so-called protein corona. While some adsorbing proteins exchange with the surroundings on a short time scale, described as a "dynamic" corona, others with higher affinity and long-lived interaction with the NP surface form a "hard" corona (HC), which is believed to mediate NP interaction with cellular machineries. In-depth NP protein corona characterization is therefore a necessary step in understanding the relationship between surface layer structure and biological outcomes. In the present work, we evaluate the protein composition and stability over time and we systematically challenge the formed complexes with surfactants. Each challenge is characterized through different physicochemical measurements (dynamic light scattering, ζ-potential, and differential centrifugal sedimentation) alongside proteomic evaluation in titration type experiments (surfactant titration). 100 nm silicon oxide (Si) and 100 nm carboxylated polystyrene (PS-COOH) NPs cloaked by human plasma HC were titrated with 3-[(3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS, zwitterionic), Triton X-100 (nonionic), sodium dodecyl sulfate (SDS, anionic), and dodecyltrimethylammonium bromide (DTAB, cationic) surfactants. Composition and density of HC together with size and ζ-potential of NP-HC complexes were tracked at each step after surfactant titration. Results on Si NP-HC complexes showed that SDS removes most of the HC, while DTAB induces NP agglomeration. Analogous results were obtained for PS NP-HC complexes. Interestingly, CHAPS and Triton X-100, thanks to similar surface binding preferences, enable selective extraction of apolipoprotein AI (ApoAI) from Si NP hard coronas, leaving unaltered the dispersion physicochemical properties. These findings indicate that surfactant titration can enable the study of NP-HC stability through surfactant variation and also selective separation

  4. Corona Borealis

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    (the Northern Crown; abbrev. CrB, gen. Coronae Borealis; area 179 sq. deg.) A northern constellation which lies between Boötes and Hercules, and culminates at midnight in mid-May. It represents the crown that in Greek mythology was made by Hephaestus, god of fire, and worn by Princess Ariadne of Crete. Its brightest stars were cataloged by Ptolemy (c. AD 100-175) in the Almagest....

  5. Solar corona/prominence seen through the White Light Coronograph

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The solar corona and a solar prominence as seen through the White Light Coronograph, Skylab Experiment S052, on January 17, 1974. This view was reproduced from a television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The bright spot is a burn in the vidicon. The solar corona is the halo around the Sun which is normally visible only at the time of solar eclipse by the Moon. The Skylab coronography uses an externally-mounted disk system which occults the brilliant solar surface while allowing the fainter radiation of the corona to enter an annulus and be photographed. A mirror system allows either TV viewing of the corona or photographic recording of the image.

  6. Core-Shell-Corona Micelles with a Responsive Shell.

    PubMed

    Gohy, Jean-François; Willet, Nicolas; Varshney, Sunil; Zhang, Jian-Xin; Jérôme, Robert

    2001-09-03

    A reactor for the synthesis of gold nanoparticles is one of the uses of a poly(styrene)-block-poly(2-vinylpyridine)-block-poly(ethylene oxide) triblock copolymer (PS-b-P2VP-b-PEO) which forms core-shell-corona micelles in water. Very low polydispersity spherical micelles are observed that consist of a PS core surrounded by a pH-sensitive P2VP shell and a corona of PEO chains end-capped by a hydroxyl group. The corona can act as a site for attaching responsive or sensing molecules. © 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

  7. Corona-assisted flame synthesis of ultrafine titania particles

    NASA Astrophysics Data System (ADS)

    Vemury, Srinivas; Pratsinis, Sotiris E.

    1995-06-01

    Synthesis of ultrafine titania particles is investigated in a diffusion flame aerosol reactor in the presence of a gaseous electric discharge (corona) created by two needle electrodes. The corona wind flattens the flame and reduces the particle residence time at high temperatures, resulting in smaller primary particle sizes and lower level of crystallinity. Increasing the applied potential from 5 to 8 kV reduces the particle size from 50 to 25 nm and the rutile content from 20 to 8 wt %. Coronas provide a clean and simple technique that facilitates gas phase synthesis of nanosized materials with controlled size and crystallinity.

  8. Electrostrictive energy conversion property of cellular electrets after corona discharge

    NASA Astrophysics Data System (ADS)

    Zhang, J. W.; Gao, F. K.; Sun, H. C.; Putson, C.; Liu, R. T.

    2018-03-01

    In this paper, the authors present the electrostrictive energy conversion ability of cellular electrets after the high-voltage corona polarization. Moreover, the electrostrictive effect of such foamed polymer before and after corona polarization has also been compared and discussed. The enhancement of electrostrictive effect of cellular electrets after corona polarization was observed. In particular, the impact on the electrostrictive effect of the macroscopic electric dipoles inside of cellular polymer which are generated by high-voltage corona poling procedure has been investigated. The present research has promoted the development of the application of electret in the field of energy conversion, actuator, transducers, etc.

  9. Implementing Kernel Methods Incrementally by Incremental Nonlinear Projection Trick.

    PubMed

    Kwak, Nojun

    2016-05-20

    Recently, the nonlinear projection trick (NPT) was introduced enabling direct computation of coordinates of samples in a reproducing kernel Hilbert space. With NPT, any machine learning algorithm can be extended to a kernel version without relying on the so called kernel trick. However, NPT is inherently difficult to be implemented incrementally because an ever increasing kernel matrix should be treated as additional training samples are introduced. In this paper, an incremental version of the NPT (INPT) is proposed based on the observation that the centerization step in NPT is unnecessary. Because the proposed INPT does not change the coordinates of the old data, the coordinates obtained by INPT can directly be used in any incremental methods to implement a kernel version of the incremental methods. The effectiveness of the INPT is shown by applying it to implement incremental versions of kernel methods such as, kernel singular value decomposition, kernel principal component analysis, and kernel discriminant analysis which are utilized for problems of kernel matrix reconstruction, letter classification, and face image retrieval, respectively.

  10. The Faraday rotation experiment. [solar corona

    NASA Technical Reports Server (NTRS)

    Volland, H.; Levy, G. S.; Bird, M. K.; Stelzried, C. T.; Seidel, B. L.

    1984-01-01

    The magnetized plasma of the solar corona was remotely sounded using the Faraday rotation effect. The solar magnetic field together with the electrons of the coronal plasma cause a measurable Faraday rotation effect, since the radio waves of Helios are linearly polarized. The measurement is performed at the ground stations. Alfven waves traveling from the Sun's surface through the corona into interplanetary space are observed. Helios 2 signals penetrating through a region where coronal mass is ejected show wavelike structures.

  11. Alfvén Waves in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Tomczyk, S.; McIntosh, S. W.; Keil, S. L.; Judge, P. G.; Schad, T.; Seeley, D. H.; Edmondson, J.

    2007-08-01

    Alfvén waves, transverse incompressible magnetic oscillations, have been proposed as a possible mechanism to heat the Sun’s corona to millions of degrees by transporting convective energy from the photosphere into the diffuse corona. We report the detection of Alfvén waves in intensity, line-of-sight velocity, and linear polarization images of the solar corona taken using the FeXIII 1074.7-nanometer coronal emission line with the Coronal Multi-Channel Polarimeter (CoMP) instrument at the National Solar Observatory, New Mexico. Ubiquitous upward propagating waves were seen, with phase speeds of 1 to 4 megameters per second and trajectories consistent with the direction of the magnetic field inferred from the linear polarization measurements. An estimate of the energy carried by the waves that we spatially resolved indicates that they are too weak to heat the solar corona; however, unresolved Alfvén waves may carry sufficient energy.

  12. Simultaneous Observation of High Temperature Plasma of Solar Corona By TESIS CORONAS-PHOTON and XRT Hinode.

    NASA Astrophysics Data System (ADS)

    Reva, A.; Kuzin, S.; Bogachev, S.; Shestov, S.

    2012-05-01

    The Mg XII spectroheliograph is a part of instrumentation complex TESIS (satellite CORONAS-PHOTON). This instrument builds monochromatic images of hot plasma of the solar corona (λ = 8.42 Å, T>5 MK). The Mg XII spectroheliograph observed hot plasma in the non-flaring active-region NOAA 11019 during nine days. We reconstructed DEM of this active region with the help of genetic algorithm (we used data of the Mg XII spectroheliograph, XRT and EIT). Emission measure of the hot component amounts 1 % of the emission measure of the cool component.

  13. Gold nanoparticle should understand protein corona for being a clinical nanomaterial.

    PubMed

    Charbgoo, Fahimeh; Nejabat, Mojgan; Abnous, Khalil; Soltani, Fatemeh; Taghdisi, Seyed Mohammad; Alibolandi, Mona; Thomas Shier, W; Steele, Terry W J; Ramezani, Mohammad

    2018-02-28

    Gold nanoparticles (AuNPs) have attracted great attention in biomedical fields due to their unique properties. However, there are few reports on clinical trial of these nanoparticles. In vivo, AuNPs face complex biological fluids containing abundant proteins, which challenge the prediction of their fate that is known as "bio-identity". These proteins attach onto the AuNPs surface forming protein corona that makes the first step of nano-bio interface and dictates the subsequent AuNPs fate. Protein corona formation even stealth active targeting effect of AuNPs. Manipulating the protein corona identity based on the researcher goal is the way to employ corona to achieve maximum effect in therapy or other applications. In this review, we provide details on the biological identity of AuNPs under various environmental- and/or physiological conditions. We also highlight how the particular corona can direct the biodistribution of AuNPs. We further discuss the strategies available for controlling or reducing corona formation on AuNPs surface and achieving desired effects using AuNPs in vivo by engineering protein corona on their surface. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. RXTE Observation of Cygnus X-1: III. Implications for Compton Corona and ADAF Models. Report 3; Implications for Compton Corona and ADAF Models

    NASA Technical Reports Server (NTRS)

    Nowak, Michael A.; Wilms, Joern; Vaughan, Brian A.; Dove, James B.; Begelman, Mitchell C.

    1999-01-01

    We have recently shown that a 'sphere + disk' geometry Compton corona model provides a good description of Rossi X-ray Timing Explorer (RXTE) observations of the hard/low state of Cygnus X-1. Separately, we have analyzed the temporal data provided by RXTE. In this paper we consider the implications of this timing analysis for our best-fit 'sphere + disk' Comptonization models. We focus our attention on the observed Fourier frequency-dependent time delays between hard and soft photons. We consider whether the observed time delays are: created in the disk but are merely reprocessed by the corona; created by differences between the hard and soft photon diffusion times in coronae with extremely large radii; or are due to 'propagation' of disturbances through the corona. We find that the time delays are most likely created directly within the corona; however, it is currently uncertain which specific model is the most likely explanation. Models that posit a large coronal radius [or equivalently, a large Advection Dominated Accretion Flow (ADAF) region] do not fully address all the details of the observed spectrum. The Compton corona models that do address the full spectrum do not contain dynamical information. We show, however, that simple phenomenological propagation models for the observed time delays for these latter models imply extremely slow characteristic propagation speeds within the coronal region.

  15. Solar corona/prominence seen through the White Light Coronograph

    NASA Image and Video Library

    1974-01-17

    S74-15697 (17 Jan. 1974) --- The solar corona and a solar prominence as seen through the White Light Coronograph, Skylab Experiment S052, on Jan. 17, 1974. This view was reproduced from a television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The bright spot is a burn in the vidicon. The solar corona is the halo around the sun which is normally visible only at the time of solar eclipse by the moon. The Skylab coronography uses an externally-mounted disk system which occults the brilliant solar surface while allowing the fainter radiation of the corona to enter an annulus and be photographed. A mirror system allows either TV viewing of the corona or photographic recording of the image. Photo credit: NASA

  16. Are All Flare Ribbons Simply Connected to the Corona?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Judge, Philip G.; Paraschiv, Alin; Lacatus, Daniela

    We consider the observational basis for the belief that flare ribbons in the chromosphere result from energy transport from the overlying corona. We study ribbons of small flares using magnetic and intensity data from the Hinode , Solar Dynamics Observatory , and IRIS missions. While most ribbons appear connected to the corona and overlie regions of significant vertical magnetic field, we examine one ribbon with no clear evidence for such connections. Evolving horizontal magnetic fields seen with Hinode suggest that reconnection with preexisting fields below the corona can explain the data. The identification of just one, albeit small, ribbon, withmore » no apparent connection to the corona, leads us to conclude that at least two mechanisms are responsible for the heating that leads to flare ribbon emission.« less

  17. Numerical modelling of ozone production in a wire-cylinder corona discharge and comparison with a wire-plate corona discharge

    NASA Astrophysics Data System (ADS)

    Wang, Pengxiang; Chen, Junhong

    2009-02-01

    The effect of electrode configuration on ozone production in the direct-current corona discharge of dry and humid air is studied by a numerical model that combines the electron distribution in the corona plasma, plasma chemistry and transport phenomena. Two electrode configurations are considered: wire-cylinder discharge with air flowing along the wire axis and wire-plate discharge with air flowing transverse to the wire. The ozone distributions in both types of discharges are compared. For both electrode configurations, the ozone production rate is higher in the negative corona than in the positive corona and it decreases with an increase in relative humidity. More importantly, the detailed ozone distribution in the neighbourhood of the discharge wire, together with the ozone kinetics, reveals the possible difference in the ozone production from the two discharges. With the same operating conditions and sufficiently short flow residence time, the ozone production rate is nearly the same for both electrode configurations. When the flow residence time is longer than the characteristic time for homogeneous ozone destruction, the net ozone production is higher in the wire-cylinder discharge than in the wire-plate discharge due to relatively less ozone destruction.

  18. The history and epidemiology of Middle East respiratory syndrome corona virus.

    PubMed

    Al-Osail, Aisha M; Al-Wazzah, Marwan J

    2017-01-01

    Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred worldwide; however, most cases of mortality have occurred in the Middle East. Owing to the predominance of outbreaks in the Middle Eastern countries, the virus was renamed a Middle East respiratory syndrome corona virus (MERS-CoV) by the Corona virus Study Group. The Center for Diseases Control and Prevention and World Health Organization maintain a website that is updated frequently with new cases of MERS-CoV infection. In this review, we describe the history and epidemiology of this novel virus. Studies of the genetics and molecular mechanisms of this virus are expected to facilitate the development of vaccines in the future.

  19. Nanoparticles-cell association predicted by protein corona fingerprints

    NASA Astrophysics Data System (ADS)

    Palchetti, S.; Digiacomo, L.; Pozzi, D.; Peruzzi, G.; Micarelli, E.; Mahmoudi, M.; Caracciolo, G.

    2016-06-01

    In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a ``protein corona'' layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes information that controls NP bioactivity (e.g. cellular association, cellular signaling pathways, biodistribution, and toxicity). Decrypting this complex code has become a priority to predict the NP biological outcomes. Here, we use a library of 16 lipid NPs of varying size (Ø ~ 100-250 nm) and surface chemistry (unmodified and PEGylated) to investigate the relationships between NP physicochemical properties (nanoparticle size, aggregation state and surface charge), protein corona fingerprints (PCFs), and NP-cell association. We found out that none of the NPs' physicochemical properties alone was exclusively able to account for association with human cervical cancer cell line (HeLa). For the entire library of NPs, a total of 436 distinct serum proteins were detected. We developed a predictive-validation modeling that provides a means of assessing the relative significance of the identified corona proteins. Interestingly, a minor fraction of the HC, which consists of only 8 PCFs were identified as main promoters of NP association with HeLa cells. Remarkably, identified PCFs have several receptors with high level of expression on the plasma membrane of HeLa cells.In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a ``protein corona'' layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes information that controls NP bioactivity (e.g. cellular association, cellular signaling pathways, biodistribution, and toxicity). Decrypting this complex code has become a priority to predict the NP biological outcomes. Here, we use a library of 16 lipid NPs of varying size (Ø ~ 100-250 nm) and surface

  20. Direct observation of laser guided corona discharges

    PubMed Central

    Wang, Tie-Jun; Wei, Yingxia; Liu, Yaoxiang; Chen, Na; Liu, Yonghong; Ju, Jingjing; Sun, Haiyi; Wang, Cheng; Lu, Haihe; Liu, Jiansheng; Chin, See Leang; Li, Ruxin; Xu, Zhizhan

    2015-01-01

    Laser based lightning control holds a promising way to solve the problem of the long standing disaster of lightning strikes. But it is a challenging project due to insufficient understanding of the interaction between laser plasma channel and high voltage electric filed. In this work, a direct observation of laser guided corona discharge is reported. Laser filament guided streamer and leader types of corona discharges were observed. An enhanced ionization took place in the leader (filament) through the interaction with the high voltage discharging field. The fluorescence lifetime of laser filament guided corona discharge was measured to be several microseconds, which is 3 orders of magnitude longer than the fluorescence lifetime of laser filaments. This work could be advantageous towards a better understanding of laser assisted leader development in the atmosphere. PMID:26679271

  1. Self-Consistent Thermal Accretion Disk Corona Models for Compact Objects. I: Properties of the Corona and the Spectrum of Escaping Radiation

    NASA Technical Reports Server (NTRS)

    Dove, James B.; Wilms, Jorn; Begelman, Mitchell C.

    1997-01-01

    We present the properties of accretion disk corona (ADC) models in which the radiation field, the temperature, and the total opacity of the corona are determined self-consistently. We use a nonlinear Monte Carlo code to perform the calculations. As an example, we discuss models in which the corona is situated above and below a cold accretion disk with a plane-parallel (slab) geometry, similar to the model of Haardt & Maraschi. By Comptonizing the soft radiation emitted by the accretion disk, the corona is responsible for producing the high-energy component of the escaping radiation. Our models include the reprocessing of radiation in the accretion disk. Here the photons either are Compton-reflected or photoabsorbed, giving rise to fluorescent line emission and thermal emission. The self- consistent coronal temperature is determined by balancing heating (due to viscous energy dissipation) with Compton cooling, determined using the fully relativistic, angle-dependent cross sections. The total opacity is found by balancing pair productions with annihilations. We find that, for a disk temperature kT(sub BB) approx. less than 200 eV, these coronae are unable to have a self-consistent temperature higher than approx. 140 keV if the total optical depth is approx. less than 0.2, regardless of the compactness parameter of the corona and the seed opacity. This limitation corresponds to the angle-averaged spectrum of escaping radiation having a photon index approx. greater than 1.8 within the 5-30 keV band. Finally, all models that have reprocessing features also predict a large thermal excess at lower energies. These constraints make explaining the X-ray spectra of persistent black hole candidates with ADC models very problematic.

  2. Comparison of direct current and 50 Hz alternating current microscopic corona characteristics on conductors

    NASA Astrophysics Data System (ADS)

    Zhang, Shuai; Zhang, Bo; He, Jinliang

    2014-06-01

    Corona discharge is one of the major design factors for extra-high voltage and ultra-high voltage DC/AC transmission lines. Under different voltages, corona discharge reveals different characteristics. This paper aims at investigating DC and AC coronas on the microscopic scale. To obtain the specific characteristics of DC and AC coronas, a new measurement approach that utilizes a coaxial wire-cylinder corona cage is designed in this paper, and wires of different diameters are used in the experiment. Based on the measurements, the respective microscopic characteristics of DC and AC coronas are analyzed and compared. With differences in characteristics between DC and AC coronas proposed, this study provides useful insights into DC/AC corona discharges on transmission line applications.

  3. Electrical-assisted double side incremental forming and processes thereof

    DOEpatents

    Roth, John; Cao, Jian

    2014-06-03

    A process for forming a sheet metal component using an electric current passing through the component is provided. The process can include providing a double side incremental forming machine, the machine operable to perform a plurality of double side incremental deformations on the sheet metal component and also apply an electric direct current to the sheet metal component during at least part of the forming. The direct current can be applied before or after the forming has started and/or be terminated before or after the forming has stopped. The direct current can be applied to any portion of the sheet metal. The electrical assistance can reduce the magnitude of force required to produce a given amount of deformation, increase the amount of deformation exhibited before failure and/or reduce any springback typically exhibited by the sheet metal component.

  4. DR-induced Hot Oxygen and Carbon Coronae of Early Mars

    NASA Astrophysics Data System (ADS)

    Zhao, J.; Chassefiere, E.; Tian, F.; Chaufray, J. Y.; Leblanc, F.

    2017-12-01

    The evolution of Martian atmosphere is a key aspect to understand the habitability of Mars in time. The distributions of neutral atoms above the exobase of ancient Mars (corona) is important for understanding the interactions between the corona and the solar wind, which could help improving our understanding of the evolution of Martian atmosphere. In this work, a 3-D Monte Carlo Model is built to simulate Martian corona in different period of Mars history based on thermosphere structure corresponding to 1, 3, 10, and 20 times present solar XUV conditions and dissociative recombination (DR) reaction profiles. DR reactions of O2+, CO2+, and CO+ are considered as the sources of primary O and C. Secondary O and C atoms, which are formed through collisions between primaries and background species. We will discuss the dependence of physical properties of Martian corona as functions of solar XUV flux and DR reactions. We will also discuss the potential importance of CO+ DR as a contributor to Martian corona.

  5. The X-ray corona and the photospheric magnetic field.

    NASA Technical Reports Server (NTRS)

    Krieger, A. S.; Vaiana, G. S.; Van Speybroeck, L. P.

    1971-01-01

    Soft X-ray photographs of the solar corona have been obtained on four flights of a rocket-borne grazing incidence telescope having a resolution of a few arc sec. The configuration of the X-ray emitting structures in the corona has been compared to the magnetic field distribution measured by photospheric longitudinal magnetograms. The X-ray structures trace the three-dimensional configuration of the magnetic field through the lower corona. Active regions in the corona take the form of tubular structures connecting regions of opposite magnetic polarity within the same or adjacent chromospheric active regions. Higher, larger structures link widely separated active regions into complexes of activity covering substantial fractions of the disk. The complexes are separated by areas of low average field in the photosphere. Interconnections across the solar equator appear to originate over areas of preceding polarity.

  6. Are All Flare Ribbons Simply Connected to the Corona?

    NASA Astrophysics Data System (ADS)

    Judge, Philip G.; Paraschiv, Alin; Lacatus, Daniela; Donea, Alina; Lindsey, Charlie

    2017-04-01

    We consider the observational basis for the belief that flare ribbons in the chromosphere result from energy transport from the overlying corona. We study ribbons of small flares using magnetic and intensity data from the Hinode, Solar Dynamics Observatory, and IRIS missions. While most ribbons appear connected to the corona and overlie regions of significant vertical magnetic field, we examine one ribbon with no clear evidence for such connections. Evolving horizontal magnetic fields seen with Hinode suggest that reconnection with preexisting fields below the corona can explain the data. The identification of just one, albeit small, ribbon, with no apparent connection to the corona, leads us to conclude that at least two mechanisms are responsible for the heating that leads to flare ribbon emission. The National Center for Atmospheric Research is sponsored by the National Science Foundation.

  7. TRIANGLE-SHAPED DC CORONA DISCHARGE DEVICE FOR MOLECULAR DECOMPOSITION

    EPA Science Inventory

    The paper discusses the evaluation of electrostatic DC corona discharge devices for the application of molecular decomposition. A point-to-plane geometry corona device with a rectangular cross section demonstrated low decomposition efficiencies in earlier experimental work. The n...

  8. Understanding the nanoparticle-protein corona complexes using computational and experimental methods.

    PubMed

    Kharazian, B; Hadipour, N L; Ejtehadi, M R

    2016-06-01

    Nanoparticles (NP) have capability to adsorb proteins from biological fluids and form protein layer, which is called protein corona. As the cell sees corona coated NPs, the protein corona can dictate biological response to NPs. The composition of protein corona is varied by physicochemical properties of NPs including size, shape, surface chemistry. Processing of protein adsorption is dynamic phenomena; to that end, a protein may desorb or leave a surface vacancy that is rapidly filled by another protein and cause changes in the corona composition mainly by the Vroman effect. In this review, we discuss the interaction between NP and proteins and the available techniques for identification of NP-bound proteins. Also we review current developed computational methods for understanding the NP-protein complex interactions. Copyright © 2016. Published by Elsevier Ltd.

  9. ZnO Nanowire-Based Corona Discharge Devices Operated Under Hundreds of Volts.

    PubMed

    Yang, Wenming; Zhu, Rong; Zong, Xianli

    2016-12-01

    Minimizing the voltage of corona discharges, especially when using nanomaterials, has been of great interest in the past decade or so. In this paper, we report a new corona discharge device by using ZnO nanowires operated in atmospheric air to realize continuous corona discharge excited by hundreds of volts. ZnO nanowires were synthesized on microelectrodes using electric-field-assisted wet chemical method, and a thin tungsten film was deposited on the microchip to enhance discharging performance. The testing results showed that the corona inception voltages were minimized greatly by using nanowires compared to conventional dischargers as a result of the local field enhancement of nanowires. The corona could be continuously generated and self-sustaining. It was proved that the law of corona inception voltage obeyed the conventional Peek's breakdown criterion. An optimal thickness of tungsten film coated over ZnO nanowires was figured out to obtain the lowest corona inception voltage. The ion concentration of the nanowire-based discharger attained 10(17)/m(3) orders of magnitude, which is practicable for most discharging applications.

  10. Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions.

    PubMed

    Simon, Johanna; Müller, Laura K; Kokkinopoulou, Maria; Lieberwirth, Ingo; Morsbach, Svenja; Landfester, Katharina; Mailänder, Volker

    2018-06-14

    Formation of the biomolecular corona ultimately determines the successful application of nanoparticles in vivo. Adsorption of biomolecules such as proteins is an inevitable process that takes place instantaneously upon contact with physiological fluid (e.g. blood). Therefore, strategies are needed to control this process in order to improve the properties of the nanoparticles and to allow targeted drug delivery. Here, we show that the design of the protein corona by a pre-formed protein corona with tailored properties enables targeted cellular interactions. Nanoparticles were pre-coated with immunoglobulin depleted plasma to create and design a protein corona that reduces cellular uptake by immune cells. It was proven that a pre-formed protein corona remains stable even after nanoparticles were re-introduced to plasma. This opens up the great potential to exploit protein corona formation, which will significantly influence the development of novel nanomaterials.

  11. Simulating halos and coronas in their atmospheric environment.

    PubMed

    David Gedzelman, Stanley

    2008-12-01

    Models are developed that simulate the light and color of the sky and of circular halos and coronas as a function of atmospheric pressure, cloud height, width, and optical depth, solar zenith angle, aerosol concentration and size, and ozone content. Halos, coronas, and skylight are treated as singly scattered sunbeams that are depleted in their passage through the atmosphere and cloud. Multiple scattering is included only for background cloud light. Halos produced by hexagonal crystal prisms and coronas produced by monodisperse droplets are visible for cloud optical depths in the range 0.0003 coronas can be bright only at smaller cloud optical depths and tend to be faint at their bottoms when produced in high cloud layers but can be bright at the horizon when produced by narrow cloud cells near ground level.

  12. Charging of moving surfaces by corona discharges sustained in air

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Jun-Chieh, E-mail: junchwan@umich.edu; Kushner, Mark J., E-mail: mjkush@umich.edu; Zhang, Daihua, E-mail: dhzhang@tju.edu.cn

    Atmospheric pressure corona discharges are used in electrophotographic (EP) printing technologies for charging imaging surfaces such as photoconductors. A typical corona discharge consists of a wire (or wire array) biased with a few hundred volts of dc plus a few kV of ac voltage. An electric discharge is produced around the corona wire from which electrons drift towards and charge the underlying dielectric surface. The surface charging reduces the voltage drop across the gap between the corona wire and the dielectric surface, which then terminates the discharge, as in a dielectric barrier discharge. In printing applications, this underlying surface ismore » continuously moving throughout the charging process. For example, previously charged surfaces, which had reduced the local electric field and terminated the local discharge, are translated out of the field of view and are replaced with uncharged surface. The uncharged surface produces a rebound in the electric field in the vicinity of the corona wire which in turn results in re-ignition of the discharge. The discharge, so reignited, is then asymmetric. We found that in the idealized corona charging system we investigated, a negatively dc biased corona blade with a dielectric covered ground electrode, the discharge is initially sustained by electron impact ionization from the bulk plasma and then dominated by ionization from sheath accelerated secondary electrons. Depending on the speed of the underlying surface, the periodic re-ignition of the discharge can produce an oscillatory charging pattern on the moving surface.« less

  13. Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide

    NASA Astrophysics Data System (ADS)

    Hajipour, Mohammad Javad; Raheb, Jamshid; Akhavan, Omid; Arjmand, Sareh; Mashinchian, Omid; Rahman, Masoud; Abdolahad, Mohammad; Serpooshan, Vahid; Laurent, Sophie; Mahmoudi, Morteza

    2015-05-01

    The hard corona, the protein shell that is strongly attached to the surface of nano-objects in biological fluids, is recognized as the first layer that interacts with biological objects (e.g., cells and tissues). The decoration of the hard corona (i.e., the type, amount, and conformation of the attached proteins) can define the biological fate of the nanomaterial. Recent developments have revealed that corona decoration strongly depends on the type of disease in human patients from which the plasma is obtained as a protein source for corona formation (referred to as the `personalized protein corona'). In this study, we demonstrate that graphene oxide (GO) sheets can trigger different biological responses in the presence of coronas obtained from various types of diseases. GO sheets were incubated with plasma from human subjects with different diseases/conditions, including hypofibrinogenemia, blood cancer, thalassemia major, thalassemia minor, rheumatism, fauvism, hypercholesterolemia, diabetes, and pregnancy. Identical sheets coated with varying protein corona decorations exhibited significantly different cellular toxicity, apoptosis, and uptake, reactive oxygen species production, lipid peroxidation and nitrogen oxide levels. The results of this report will help researchers design efficient and safe, patient-specific nano biomaterials in a disease type-specific manner for clinical and biological applications.The hard corona, the protein shell that is strongly attached to the surface of nano-objects in biological fluids, is recognized as the first layer that interacts with biological objects (e.g., cells and tissues). The decoration of the hard corona (i.e., the type, amount, and conformation of the attached proteins) can define the biological fate of the nanomaterial. Recent developments have revealed that corona decoration strongly depends on the type of disease in human patients from which the plasma is obtained as a protein source for corona formation (referred

  14. Visualization of the protein corona: towards a biomolecular understanding of nanoparticle-cell-interactions.

    PubMed

    Kokkinopoulou, Maria; Simon, Johanna; Landfester, Katharina; Mailänder, Volker; Lieberwirth, Ingo

    2017-06-29

    The use of nanocarriers in biology and medicine is complicated by the current need to understand how nanoparticles interact in complex biological surroundings. When nanocarriers come into contact with serum, proteins immediately adsorb onto their surface, forming a protein corona which defines their biological identity. Although the composition of the protein corona has been widely determined by proteomics, its morphology still remains unclear. In this study we show for the first time the morphology of the protein corona using transmission electron microscopy. We are able to demonstrate that the protein corona is not, as commonly supposed, a dense, layered shell coating the nanoparticle, but an undefined, loose network of proteins. Additionally, we are now able to visualize and discriminate between the soft and hard corona using centrifugation-based separation techniques together with proteomic characterization. The protein composition of the ∼15 nm hard corona strongly depends on the surface chemistry of the respective nanomaterial, thus further affecting cellular uptake and intracellular trafficking. Large diameter protein corona resulting from pre-incubation with soft corona or Apo-A1 inhibits cellular uptake, confirming the stealth-effect mechanism. In summary, the knowledge on protein corona formation, composition and morphology is essential to design therapeutic effective nanoparticle systems.

  15. The nanoparticle protein corona formed in human blood or human blood fractions.

    PubMed

    Lundqvist, Martin; Augustsson, Cecilia; Lilja, Malin; Lundkvist, Kristoffer; Dahlbäck, Björn; Linse, Sara; Cedervall, Tommy

    2017-01-01

    The protein corona formed around nanoparticles in protein-rich fluids plays an important role for nanoparticle biocompatibility, as found in several studies during the last decade. Biological fluids have complex compositions and the molecular components interact and function together in intricate networks. Therefore, the process to isolate blood or the preparation of blood derivatives may lead to differences in the composition of the identified protein corona around nanoparticles. Here, we show distinct differences in the protein corona formed in whole blood, whole blood with EDTA, plasma, or serum. Furthermore, the ratio between particle surface area to protein concentration influences the detected corona. We also show that the nanoparticle size per se influences the formed protein corona due to curvature effects. These results emphasize the need of investigating the formation and biological importance of the protein corona in the same environment as the nanoparticles are intended for or released into.

  16. Current-voltage characteristics of dc corona discharges in air between coaxial cylinders

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zheng, Yuesheng, E-mail: yueshengzheng@fzu.edu.cn; Zhang, Bo, E-mail: shizbcn@tsinghua.edu.cn; He, Jinliang, E-mail: hejl@tsinghua.edu.cn

    This paper presents the experimental measurement and numerical analysis of the current-voltage characteristics of dc corona discharges in air between coaxial cylinders. The current-voltage characteristics for both positive and negative corona discharges were measured within a specially designed corona cage. Then the measured results were fitted by different empirical formulae and analyzed by the fluid model. The current-voltage characteristics between coaxial cylinders can be expressed as I = C(U − U{sub 0}){sup m}, where m is within the range 1.5–2.0, which is similar to the point-plane electrode system. The ionization region has no significant effect on the current-voltage characteristic under a low corona current,more » while it will affect the distribution for the negative corona under a high corona current. The surface onset fields and ion mobilities were emphatically discussed.« less

  17. Exploiting Outage and Error Probability of Cooperative Incremental Relaying in Underwater Wireless Sensor Networks

    PubMed Central

    Nasir, Hina; Javaid, Nadeem; Sher, Muhammad; Qasim, Umar; Khan, Zahoor Ali; Alrajeh, Nabil; Niaz, Iftikhar Azim

    2016-01-01

    This paper embeds a bi-fold contribution for Underwater Wireless Sensor Networks (UWSNs); performance analysis of incremental relaying in terms of outage and error probability, and based on the analysis proposition of two new cooperative routing protocols. Subject to the first contribution, a three step procedure is carried out; a system model is presented, the number of available relays are determined, and based on cooperative incremental retransmission methodology, closed-form expressions for outage and error probability are derived. Subject to the second contribution, Adaptive Cooperation in Energy (ACE) efficient depth based routing and Enhanced-ACE (E-ACE) are presented. In the proposed model, feedback mechanism indicates success or failure of data transmission. If direct transmission is successful, there is no need for relaying by cooperative relay nodes. In case of failure, all the available relays retransmit the data one by one till the desired signal quality is achieved at destination. Simulation results show that the ACE and E-ACE significantly improves network performance, i.e., throughput, when compared with other incremental relaying protocols like Cooperative Automatic Repeat reQuest (CARQ). E-ACE and ACE achieve 69% and 63% more throughput respectively as compared to CARQ in hard underwater environment. PMID:27420061

  18. Instrumentation for investigation of corona discharges from insulated wires

    NASA Technical Reports Server (NTRS)

    Doreswamy, C. V.; Crowell, C. S.

    1975-01-01

    A coaxial cylinder configuration is used to investigate the effect of corona impulses on the deterioration of electrical insulation. The corona currents flowing through the resistance develop a voltage which is fed to the measuring set-up. The value of this resistance is made equal to the surge impedance of the coaxial cylinder set up to prevent reflections. This instrumentation includes a phase shifter and Schmidt trigger and is designed to sample, measure, and display corona impulses occurring during any predetermined sampling period of a randomly selectable half cycle of the 60 Hz high voltage wave.

  19. Corona evaluation for 270 volt dc systems

    NASA Astrophysics Data System (ADS)

    Dunbar, William G.

    When designing 270 V dc power system electronics and wiring systems, it is essential to evaluate such corona-initiation-prone parts with bare electrodes as terminations and leads, and to take into account spacings, gas pressures (as a function of maximum altitude), temperature, voltage transients, and insulation coating thickness. Both persistent and intermittent transients are important. Filters and transient suppressors are excellent methods for limiting overvoltage transients in order to prevent corona initiation within a module.

  20. Comparison of direct current and 50 Hz alternating current microscopic corona characteristics on conductors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Shuai, E-mail: zhangshuai94@gmail.com; Zhang, Bo, E-mail: shizbcn@mail.tsinghua.edu.cn; He, Jinliang, E-mail: hejl@tsinghua.edu.cn

    Corona discharge is one of the major design factors for extra-high voltage and ultra-high voltage DC/AC transmission lines. Under different voltages, corona discharge reveals different characteristics. This paper aims at investigating DC and AC coronas on the microscopic scale. To obtain the specific characteristics of DC and AC coronas, a new measurement approach that utilizes a coaxial wire-cylinder corona cage is designed in this paper, and wires of different diameters are used in the experiment. Based on the measurements, the respective microscopic characteristics of DC and AC coronas are analyzed and compared. With differences in characteristics between DC and ACmore » coronas proposed, this study provides useful insights into DC/AC corona discharges on transmission line applications.« less

  1. Observational Signatures of Magnetic Reconnection in the Extended Corona

    NASA Technical Reports Server (NTRS)

    Savage, Sabrina; West, Matthew J.; Seaton, Daniel B.; Kobelski, Adam

    2016-01-01

    Observational signatures of reconnection have been studied extensively in the lower corona for decades, successfully providing insight into energy release mechanisms in the region above post-flare arcade loops and below 1.5 solar radii. During large eruptive events, however, energy release continues to occur well beyond the presence of reconnection signatures at these low heights. Supra-Arcade Downflows (SADs) and Supra-Arcade Downflowing Loops (SADLs) are particularly useful measures of continual reconnection in the corona as they may indicate the presence and path of retracting post-reconnection loops. SADs and SADLs have been faintly observed up to 18 hours beyond the passage of coronas mass ejections through the SOHO/LASCO field of view, but a recent event from 2014 October 14 associated with giant arches provides very clear observations of these downflows for days after the initial eruption. We report on this unique event and compare these findings with observational signatures of magnetic reconnection in the extended corona for more typical eruptions.

  2. Observational Signatures of Magnetic Reconnection in the Extended Corona

    NASA Technical Reports Server (NTRS)

    Savage, Sabrina; West, Matthew J.; Seaton, Danial B.; Kobelski, Adam

    2016-01-01

    Observational signatures of reconnection have been studied extensively in the lower corona for decades, successfully providing insight into energy release mechanisms in the region above post-flare arcade loops and below 1.5 solar radii. During large eruptive events, however, energy release continues to occur well beyond the presence of reconnection signatures at these low heights. Supra-Arcade Downflows (SADs) and Supra-Arcade Downflowing Loops (SADLs) are particularly useful measures of continual reconnection in the corona as they may indicate the presence and path of retracting post-reconnection loops. SADs and SADLs have been faintly observed up to 18 hours beyond the passage of corona mass ejections through the SOHO/LASCO field of view, but a recent event from 2014 October 14 associated with giant arches provides very clear observations of these downflows for days after the initial eruption. We report on this unique event and compare these findings with observational signatures of magnetic reconnection in the extended corona for more typical eruptions.

  3. Observational Signatures of Magnetic Reconnection in the Extended Corona

    NASA Technical Reports Server (NTRS)

    Savage, Sabrina; West, Matthew J.; Seaton, Daniel B.; Kobelski, Adam

    2017-01-01

    Observational signatures of reconnection have been studied extensively in the lower corona for decades, successfully providing insight into energy release mechanisms in the region above post-flare arcade loops and below 1.5 solar radii. During large eruptive events, however, energy release continues to occur well beyond the presence of reconnection signatures at these low heights. Supra-Arcade Downflows (SADs) and Supra-Arcade Downflowing Loops (SADLs) are particularly useful measures of continual reconnection in the corona as they may indicate the presence and path of retracting post-reconnection loops. SADs and SADLs have been faintly observed up to 18 hours beyond the passage of corona mass ejections through the SOHO/LASCO field of view, but a recent event from 2014 October 14 associated with giant arches provides very clear observations of these downflows for days after the initial eruption. We report on this unique event and compare these findings with observational signatures of magnetic reconnection in the extended corona for more typical eruptions.

  4. Protein Corona Analysis of Silver Nanoparticles Links to Their Cellular Effects.

    PubMed

    Juling, Sabine; Niedzwiecka, Alicia; Böhmert, Linda; Lichtenstein, Dajana; Selve, Sören; Braeuning, Albert; Thünemann, Andreas F; Krause, Eberhard; Lampen, Alfonso

    2017-11-03

    The breadth of applications of nanoparticles and the access to food-associated consumer products containing nanosized materials lead to oral human exposure to such particles. In biological fluids nanoparticles dynamically interact with biomolecules and form a protein corona. Knowledge about the protein corona is of great interest for understanding the molecular effects of particles as well as their fate inside the human body. We used a mass spectrometry-based toxicoproteomics approach to elucidate mechanisms of toxicity of silver nanoparticles and to comprehensively characterize the protein corona formed around silver nanoparticles in Caco-2 human intestinal epithelial cells. Results were compared with respect to the cellular function of proteins either affected by exposure to nanoparticles or present in the protein corona. A transcriptomic data set was included in the analyses in order to obtain a combined multiomics view of nanoparticle-affected cellular processes. A relationship between corona proteins and the proteomic or transcriptomic responses was revealed, showing that differentially regulated proteins or transcripts were engaged in the same cellular signaling pathways. Protein corona analyses of nanoparticles in cells might therefore help in obtaining information about the molecular consequences of nanoparticle treatment.

  5. Spatial and temporal relations between coronae and extensional belts, northern Lada Terra, Venus

    NASA Astrophysics Data System (ADS)

    Baer, G.; Schubert, G.; Bindschadler, D. L.; Stofan, E. R.

    1994-04-01

    Preliminary studies of the distribution of coronae and volcanic rises on Venus show that many of these features tend to cluster along zones of rifting and extension. The plains north of Lada Terra are crossed by two such extensional belts. Each belt is composed of grabens, ridges, faults, volcanic flows, coronae and coronalike features. The longer and more prominent belt is the NW trending Alpha-Lada extensional belt, which is over 6000 km long and 50-200 km wide, and includes the coronae Eve, Tamfana, Carpo, Selu, Derceto, Otygen, and an unnamed corona south of Otygen. The second belt is the NNE trending Derceto-Quetzalpetlatl extensional belt, which is about 2000 km long and in places over 300 km wide, and includes the coronae Sarpanitum, Eithinoha, and Quetzalpetlatl. The two belts intersect at the 1600 x 600 km wide Derceto volcanic plateau. It is apparent that deformation along the two belts overlapped in time, though deformation along the Alpha-Lada extensional belt probably continued after the deformation along the Derceto-Quetzalpetlatl extensional belt terminated. In certain areas, volcanism originated in grabens within the extensional belts, whereas in other areas, such as in Eve, Selu, Derceto, and Quetzalpetlatl, volcanism originated in the coronae and flowed into the lower parts of the extensional belts. Regional extension has affected the evolution of all the coronae at some stage of their development. Regional deformation occurred before the initiation of Derceto and Eithinoha of their development. Regional deformation occurred before the initiation of Derceto and Eithinoha and after the initiation of Carpo, Tamfana, Otygen, and Sarpanitum. It is thus unlikely that coronae formation along the belts is solely a consequence of the regional extension, and it is also unlikely that regional extension has been caused solely by the coronae. No corona along the belts was formed subsequent to the cessation of the regional extension. We therefore suggest that

  6. Corona inception voltage in statorettes with various gas-solid dielectric systems

    NASA Technical Reports Server (NTRS)

    Bollenbacher, G.; Kempke, E. E., Jr.

    1972-01-01

    Corona inception voltage was calculated and measured for three statorettes in several gases and gas mixtures at pressures from 50.8 to 1270 torr. In helium the corona inception voltage was lowest, and in air it was highest. In argon and mixtures of helium and xenon the corona inception voltage was between that of air and helium. Correlation between experimental and calculated data was good.

  7. Unveiling the in Vivo Protein Corona of Circulating Leukocyte-like Carriers.

    PubMed

    Corbo, Claudia; Molinaro, Roberto; Taraballi, Francesca; Toledano Furman, Naama E; Hartman, Kelly A; Sherman, Michael B; De Rosa, Enrica; Kirui, Dickson K; Salvatore, Francesco; Tasciotti, Ennio

    2017-03-28

    Understanding interactions occurring at the interface between nanoparticles and biological components is an urgent challenge in nanomedicine due to their effect on the biological fate of nanoparticles. After the systemic injection of nanoparticles, a protein corona constructed by blood components surrounds the carrier's surface and modulates its pharmacokinetics and biodistribution. Biomimicry-based approaches in nanotechnology attempt to imitate what happens in nature in order to transfer specific natural functionalities to synthetic nanoparticles. Several biomimetic formulations have been developed, showing superior in vivo features as a result of their cell-like identity. We have recently designed biomimetic liposomes, called leukosomes, which recapitulate the ability of leukocytes to target inflamed endothelium and escape clearance by the immune system. To gain insight into the properties of leukosomes, we decided to investigate their protein corona in vivo. So far, most information about the protein corona has been obtained using in vitro experiments, which have been shown to minimally reproduce in vivo phenomena. Here we directly show a time-dependent quantitative and qualitative analysis of the protein corona adsorbed in vivo on leukosomes and control liposomes. We observed that leukosomes absorb fewer proteins than liposomes, and we identified a group of proteins specifically adsorbed on leukosomes. Moreover, we hypothesize that the presence of macrophage receptors on leukosomes' surface neutralizes their protein corona-meditated uptake by immune cells. This work unveils the protein corona of a biomimetic carrier and is one of the few studies on the corona performed in vivo.

  8. Three-dimensional time domain model of lightning including corona effects

    NASA Technical Reports Server (NTRS)

    Podgorski, Andrew S.

    1991-01-01

    A new 3-D lightning model that incorporates the effect of corona is described for the first time. The new model is based on a Thin Wire Time Domain Lightning (TWTDL) Code developed previously. The TWTDL Code was verified during the 1985 and 1986 lightning seasons by the measurements conducted at the 553 m CN Tower in Toronto, Ontario. The inclusion of corona in the TWTDL code allowed study of the corona effects on the lightning current parameters and the associated electric field parameters.

  9. The New Solar Corona

    NASA Technical Reports Server (NTRS)

    Aschwanden, Markus J.; Poland, Arthur I.; Rabin, Douglas M.; Fisher, Richard R. (Technical Monitor)

    2001-01-01

    We focus on new observational capabilities (Yohkoh, SoHO, TRACE) observations, modeling, approaches, and insights into physical processes of the solar corona. The most impressive new results and problems discussed in this article can be appreciated from the movies and available on the Annual Reviews web site.

  10. Positive direct current corona discharges in single wire-duct electrostatic precipitators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yehia, Ashraf, E-mail: yehia30161@yahoo.com; Department of Physics, Faculty of Science, Assiut University, Assiut 71516, Arab Republic of Egypt; Abdel-Fattah, E.

    This paper is aimed to study the characteristics of the positive dc corona discharges in single wire-duct electrostatic precipitators. Therefore, the corona discharges were formed inside dry air fed single wire-duct reactor under positive dc voltage at the normal atmospheric conditions. The corona current-voltage characteristics curves have been measured in parallel with the ozone concentration generated inside the reactor under different discharge conditions. The corona current-voltage characteristics curves have agreed with a semi empirical equation derived from the previous studies. The experimental results of the ozone concentration generated inside the reactor were formulated in the form of an empirical equationmore » included the different parameters that were studied experimentally. The obtained equations are valid to expect both the current-voltage characteristics curves and the corresponding ozone concentration that generates with the positive dc corona discharges inside single wire-duct electrostatic precipitators under any operating conditions in the same range of the present study.« less

  11. Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide.

    PubMed

    Hajipour, Mohammad Javad; Raheb, Jamshid; Akhavan, Omid; Arjmand, Sareh; Mashinchian, Omid; Rahman, Masoud; Abdolahad, Mohammad; Serpooshan, Vahid; Laurent, Sophie; Mahmoudi, Morteza

    2015-05-21

    The hard corona, the protein shell that is strongly attached to the surface of nano-objects in biological fluids, is recognized as the first layer that interacts with biological objects (e.g., cells and tissues). The decoration of the hard corona (i.e., the type, amount, and conformation of the attached proteins) can define the biological fate of the nanomaterial. Recent developments have revealed that corona decoration strongly depends on the type of disease in human patients from which the plasma is obtained as a protein source for corona formation (referred to as the 'personalized protein corona'). In this study, we demonstrate that graphene oxide (GO) sheets can trigger different biological responses in the presence of coronas obtained from various types of diseases. GO sheets were incubated with plasma from human subjects with different diseases/conditions, including hypofibrinogenemia, blood cancer, thalassemia major, thalassemia minor, rheumatism, fauvism, hypercholesterolemia, diabetes, and pregnancy. Identical sheets coated with varying protein corona decorations exhibited significantly different cellular toxicity, apoptosis, and uptake, reactive oxygen species production, lipid peroxidation and nitrogen oxide levels. The results of this report will help researchers design efficient and safe, patient-specific nano biomaterials in a disease type-specific manner for clinical and biological applications.

  12. Dynamics of nanoparticle-protein corona complex formation: analytical results from population balance equations.

    PubMed

    Darabi Sahneh, Faryad; Scoglio, Caterina; Riviere, Jim

    2013-01-01

    Nanoparticle-protein corona complex formation involves absorption of protein molecules onto nanoparticle surfaces in a physiological environment. Understanding the corona formation process is crucial in predicting nanoparticle behavior in biological systems, including applications of nanotoxicology and development of nano drug delivery platforms. This paper extends the modeling work in to derive a mathematical model describing the dynamics of nanoparticle corona complex formation from population balance equations. We apply nonlinear dynamics techniques to derive analytical results for the composition of nanoparticle-protein corona complex, and validate our results through numerical simulations. The model presented in this paper exhibits two phases of corona complex dynamics. In the first phase, proteins rapidly bind to the free surface of nanoparticles, leading to a metastable composition. During the second phase, continuous association and dissociation of protein molecules with nanoparticles slowly changes the composition of the corona complex. Given sufficient time, composition of the corona complex reaches an equilibrium state of stable composition. We find analytical approximate formulae for metastable and stable compositions of corona complex. Our formulae are very well-structured to clearly identify important parameters determining corona composition. The dynamics of biocorona formation constitute vital aspect of interactions between nanoparticles and living organisms. Our results further understanding of these dynamics through quantitation of experimental conditions, modeling results for in vitro systems to better predict behavior for in vivo systems. One potential application would involve a single cell culture medium related to a complex protein medium, such as blood or tissue fluid.

  13. A table of intensity increments.

    DOT National Transportation Integrated Search

    1966-01-01

    Small intensity increments can be produced by adding larger intensity increments. A table is presented covering the range of small intensity increments from 0.008682 through 6.020 dB in 60 large intensity increments of 1 dB.

  14. Measurement of positive direct current corona pulse in coaxial wire-cylinder gap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yin, Han, E-mail: hanyin1986@gmail.com; Zhang, Bo, E-mail: shizbcn@mail.tsinghua.edu.cn; He, Jinliang, E-mail: hejl@tsinghua.edu.cn

    In this paper, a system is designed and developed to measure the positive corona current in coaxial wire-cylinder gaps. The characteristic parameters of corona current pulses, such as the amplitude, rise time, half-wave time, and repetition frequency, are statistically analyzed and a new set of empirical formulas are derived by numerical fitting. The influence of space charges on corona currents is tested by using three corona cages with different radii. A numerical method is used to solve a simplified ion-flow model to explain the influence of space charges. Based on the statistical results, a stochastic model is developed to simulatemore » the corona pulse trains. And this model is verified by comparing the simulated frequency-domain responses with the measured ones.« less

  15. Protein Corona Composition Does Not Accurately Predict Hematocompatibility of Colloidal Gold Nanoparticles

    PubMed Central

    Dobrovolskaia, Marina A.; Neun, Barry W.; Man, Sonny; Ye, Xiaoying; Hansen, Matthew; Patri, Anil K.; Crist, Rachael M.; McNeil, Scott E.

    2014-01-01

    Proteins bound to nanoparticle surfaces are known to affect particle clearance by influencing immune cell uptake and distribution to the organs of the mononuclear phagocytic system. The composition of the protein corona has been described for several types of nanomaterials, but the role of the corona in nanoparticle biocompatibility is not well established. In this study we investigate the role of nanoparticle surface properties (PEGylation) and incubation times on the protein coronas of colloidal gold nanoparticles. While neither incubation time nor PEG molecular weight affected the specific proteins in the protein corona, the total amount of protein binding was governed by the molecular weight of PEG coating. Furthermore, the composition of the protein corona did not correlate with nanoparticle hematocompatibility. Specialized hematological tests should be used to deduce nanoparticle hematotoxicity. PMID:24512761

  16. Chromophore Poling in Thin Films of Organic Glasses. 2. Two-Electrode Corona Discharge Setup

    NASA Astrophysics Data System (ADS)

    Vilitis, O.; Muzikante, I.; Rutkis, M.; Vembris, A.

    2012-01-01

    In Part 1 of the article we provided description of the corona discharge physics and overview of the methods used for corona poling in thin organic films. Subsequent sections describe comparatively simple technical methods for poling the organic nonlinear optical polymers using a two-electrode (point-to-plate or wire-to-plate) technique. The polarization build-up was studied by the DC positive corona method for poling the nonlinear optical (NLO) polymers. The experimental setup provides the corona discharge current from 0.5 μA up to 3 μA by applying 3 kV - 12 kV voltage to the corona electrode and makes possible selection among the types of corona electrodes (needle, multi-needle, wire, etc.). The results of experimental testing of the poling setup show that at fixed optimal operational parameters of poling - the sample orientation temperature and the discharge current - the corona charging of polymeric materials can successfully be performed applying the two-electrode technique. To study the dynamics of both poling and charge transport processes the three-electrode charging system - a corona triode - should be applied.

  17. Compensating Faraday Depolarization by Magnetic Helicity in the Solar Corona

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brandenburg, Axel; Ashurova, Mohira B.; Jabbari, Sarah, E-mail: brandenb@nordita.org

    A turbulent dynamo in spherical geometry with an outer corona is simulated to study the sign of magnetic helicity in the outer parts. In agreement with earlier studies, the sign in the outer corona is found to be opposite to that inside the dynamo. Line-of-sight observations of polarized emission are synthesized to explore the feasibility of using the local reduction of Faraday depolarization to infer the sign of helicity of magnetic fields in the solar corona. This approach was previously identified as an observational diagnostic in the context of galactic magnetic fields. Based on our simulations, we show that thismore » method can be successful in the solar context if sufficient statistics are gathered by using averages over ring segments in the corona separately for the regions north and south of the solar equator.« less

  18. Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona.

    PubMed

    Ahsan, Saad Mohammad; Rao, Chintalagiri Mohan; Ahmad, Md Faiz

    2018-01-01

    The physico-chemical properties of nanoparticles, as characterized under idealized laboratory conditions, have been suggested to differ significantly when studied under complex physiological environments. A major reason for this variation has been the adsorption of biomolecules (mainly proteins) on the nanoparticle surface, constituting the so-called "biomolecular corona". The formation of biomolecular corona on the nanoparticle surface has been reported to influence various nanoparticle properties viz. cellular targeting, cellular interaction, in vivo clearance, toxicity, etc. Understanding the interaction of nanoparticles with proteins upon administration in vivo thus becomes important for the development of effective nanotechnology-based platforms for biomedical applications. In this chapter, we describe the formation of protein corona on nanoparticles and the differences arising in its composition due to variations in nanoparticle properties. Also discussed is the influence of protein corona on various nanoparticle activities.

  19. Preservation of the soft protein corona in distinct flow allows identification of weakly bound proteins.

    PubMed

    Weber, C; Simon, J; Mailänder, V; Morsbach, S; Landfester, K

    2018-06-08

    Nanocarriers that are used for targeted drug delivery come in contact with biological liquids and subsequently proteins will adsorb to the nanocarriers' surface to form the so called 'protein corona'. The protein corona defines the biological identity and determines the biological response towards the nanocarriers in the body. To make nanomedicine safe and reliable it is required to get a better insight into this protein corona and, therefore, the adsorbed proteins have to be characterized. Currently, centrifugation is the common method to isolate the protein corona for further investigations. However, with this method it is only possible to investigate the strongly bound proteins, also referred to as 'hard protein corona'. Therefore, we want to introduce a new separation technique to separate nanoparticles including the soft protein corona containing also loosely bound proteins for further characterization. The used separation technique is the asymmetric flow field-flow fractionation (AF4). We were able to separate the nanoparticles with proteins forming the soft protein corona and were able to show that in our system only the hard protein corona directly influenced the cell uptake behavior. Currently, there is an ongoing debate whether only strongly bound proteins (hard corona) or also loosely bound proteins (soft corona) contribute to the biological identity of nanocarriers, because up to now isolation of the soft corona was not possible. Here, asymmetric flow field-flow fractionation was used to isolate nanoparticles with a preserved soft corona from the biological medium. This enabled the characterization of the soft corona composition and to evaluate its influence on cellular uptake. For our system we found that only the strongly bound proteins (hard corona) determined cell internalization. This method can now be used to evaluate the impact of the soft corona further and to characterize nanomaterials that cannot be separated from blood plasma by other means

  20. 76 FR 3655 - Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and Riverside...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

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  1. Results of Spectral Corona Observations in Solar Activity Cycles 17-24

    NASA Astrophysics Data System (ADS)

    Aliev, A. Kh.; Guseva, S. A.; Tlatov, A. G.

    2017-12-01

    The results of the work of the global observation network are considered, and a comparative analysis of the data of various coronal observatories is performed. The coronal activity index has been reconstructed for the period 1939-2016 based on the data of various observatories in Kislovodsk system. For this purpose, the corona daily intensity maps from the Sacramento Peak and Lomnický Štít observatories according to the Solar-Geophysical Data journal have been digitized; they supplement the data of other observatories. The homogeneity and continuity of the corona observations at the Kislovodsk station, including activity cycle 24, is confirmed. Unfortunately, the only observatory at present that continues observation of the spectral corona in Fe XIV 5303 Å and Fe XIV 6374 Å lines is the Kislovodsk astronomical station Mountain Astronomical Station (MAS) of the Central Astronomical Observatory, Russian Academy of Sciences (Pulkovo). The data on the combined corona in 5303 Å line are analyzed. It is shown that there is a high correlation of the intensity index of green corona with solar radiation measurements in the vacuum UV region. Data on the beginning of the new 25th activity cycle in the corona at high latitudes are presented.

  2. Protein Corona Influences Cell-Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds.

    PubMed

    Serpooshan, Vahid; Mahmoudi, Morteza; Zhao, Mingming; Wei, Ke; Sivanesan, Senthilkumar; Motamedchaboki, Khatereh; Malkovskiy, Andrey V; Gladstone, Andrew B; Cohen, Jeffrey E; Yang, Phillip C; Rajadas, Jayakumar; Bernstein, Daniel; Woo, Y Joseph; Ruiz-Lozano, Pilar

    2015-07-22

    Biomaterials are extensively used to restore damaged tissues, in the forms of implants (e.g. tissue engineered scaffolds) or biomedical devices (e.g. pacemakers). Once in contact with the physiological environment, nanostructured biomaterials undergo modifications as a result of endogenous proteins binding to their surface. The formation of this macromolecular coating complex, known as 'protein corona', onto the surface of nanoparticles and its effect on cell-particle interactions are currently under intense investigation. In striking contrast, protein corona constructs within nanostructured porous tissue engineering scaffolds remain poorly characterized. As organismal systems are highly dynamic, it is conceivable that the formation of distinct protein corona on implanted scaffolds might itself modulate cell-extracellular matrix interactions. Here, we report that corona complexes formed onto the fibrils of engineered collagen scaffolds display specific, distinct, and reproducible compositions that are a signature of the tissue microenvironment as well as being indicative of the subject's health condition. Protein corona formed on collagen matrices modulated cellular secretome in a context-specific manner ex-vivo , demonstrating their role in regulating scaffold-cellular interactions. Together, these findings underscore the importance of custom-designing personalized nanostructured biomaterials, according to the biological milieu and disease state. We propose the use of protein corona as in situ biosensor of temporal and local biomarkers.

  3. Monitoring of the Enzymatic Degradation of Protein Corona and Evaluating the Accompanying Cytotoxicity of Nanoparticles.

    PubMed

    Ma, Zhifang; Bai, Jing; Jiang, Xiue

    2015-08-19

    Established nanobio interactions face the challenge that the formation of nanoparticle-protein corona complexes shields the inherent properties of the nanoparticles and alters the manner of the interactions between nanoparticles and biological systems. Therefore, many studies have focused on protein corona-mediated nanoparticle binding, internalization, and intracellular transportation. However, there are a few studies to pay attention to if the corona encounters degradation after internalization and how the degradation of the protein corona affects cytotoxicity. To fill this gap, we prepared three types of off/on complexes based on gold nanoparticles (Au NPs) and dye-labeled serum proteins and studied the extracellular and intracellular proteolytic processes of protein coronas as well as their accompanying effects on cytotoxicity through multiple evaluation mechanisms, including cell viability, adenosine triphosphate (ATP) content, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS). The proteolytic process was confirmed by recovery of the fluorescence of the dye-labeled protein molecules that was initially quenched by Au NPs. Our results indicate that the degradation rate of protein corona is dependent on the type of the protein based on systematical evaluation of the extracellular and intracellular degradation processes of the protein coronas formed by human serum albumin (HSA), γ-globulin (HGG), and serum fibrinogen (HSF). Degradation is the fastest for HSA corona and the slowest for HSF corona. Notably, we also find that the Au NP-HSA corona complex induces lower cell viability, slower ATP production, lower MMP, and higher ROS levels. The cytotoxicity of the nanoparticle-protein corona complex may be associated with the protein corona degradation process. All of these results will enrich the database of cytotoxicity induced by nanomaterial-protein corona complexes.

  4. Utilizing the protein corona around silica nanoparticles for dual drug loading and release

    NASA Astrophysics Data System (ADS)

    Shahabi, Shakiba; Treccani, Laura; Dringen, Ralf; Rezwan, Kurosch

    2015-10-01

    A protein corona forms spontaneously around silica nanoparticles (SNPs) in serum-containing media. To test whether this protein corona can be utilized for the loading and release of anticancer drugs we incorporated the hydrophilic doxorubicin, the hydrophobic meloxicam as well as their combination in the corona around SNPs. The application of corona-covered SNPs to osteosarcoma cells revealed that drug-free particles did not affect the cell viability. In contrast, SNPs carrying a protein corona with doxorubicin or meloxicam lowered the cell proliferation in a concentration-dependent manner. In addition, these particles had an even greater antiproliferative potential than the respective concentrations of free drugs. The best antiproliferative effects were observed for SNPs containing both doxorubicin and meloxicam in their corona. Co-localization studies revealed the presence of doxorubicin fluorescence in the nucleus and lysosomes of cells exposed to doxorubicin-containing coated SNPs, suggesting that endocytotic uptake of the SNPs facilitates the cellular accumulation of the drug. Our data demonstrate that the protein corona, which spontaneously forms around nanoparticles, can be efficiently exploited for loading the particles with multiple drugs for therapeutic purposes. As drugs are efficiently released from such particles they may have a great potential for nanomedical applications.A protein corona forms spontaneously around silica nanoparticles (SNPs) in serum-containing media. To test whether this protein corona can be utilized for the loading and release of anticancer drugs we incorporated the hydrophilic doxorubicin, the hydrophobic meloxicam as well as their combination in the corona around SNPs. The application of corona-covered SNPs to osteosarcoma cells revealed that drug-free particles did not affect the cell viability. In contrast, SNPs carrying a protein corona with doxorubicin or meloxicam lowered the cell proliferation in a concentration

  5. Topographic Corona Gravity Survey Results

    NASA Technical Reports Server (NTRS)

    Comstock, R. L.; Smrekar, S. E.; Anderson, F. S.

    2001-01-01

    We present estimates for elastic and crustal thickness obtained from a gravity survey of Venusian topographic coronae, and characterize advantages and disadvantages for generating spectral admittance. Additional information is contained in the original extended abstract.

  6. Semi-analytical modelling of positive corona discharge in air

    NASA Astrophysics Data System (ADS)

    Pontiga, Francisco; Yanallah, Khelifa; Chen, Junhong

    2013-09-01

    Semianalytical approximate solutions of the spatial distribution of electric field and electron and ion densities have been obtained by solving Poisson's equations and the continuity equations for the charged species along the Laplacian field lines. The need to iterate for the correct value of space charge on the corona electrode has been eliminated by using the corona current distribution over the grounded plane derived by Deutsch, which predicts a cos m θ law similar to Warburg's law. Based on the results of the approximated model, a parametric study of the influence of gas pressure, the corona wire radius, and the inter-electrode wire-plate separation has been carried out. Also, the approximate solutions of the electron number density has been combined with a simplified plasma chemistry model in order to compute the ozone density generated by the corona discharge in the presence of a gas flow. This work was supported by the Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia) and by the Ministerio de Ciencia e Innovacion, Spain, within the European Regional Development Fund contracts FQM-4983 and FIS2011-25161.

  7. A Comparison between Physics-based and Polytropic MHD Models for Stellar Coronae and Stellar Winds of Solar Analogs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cohen, O.

    The development of the Zeeman–Doppler Imaging (ZDI) technique has provided synoptic observations of surface magnetic fields of low-mass stars. This led the stellar astrophysics community to adopt modeling techniques that have been used in solar physics using solar magnetograms. However, many of these techniques have been neglected by the solar community due to their failure to reproduce solar observations. Nevertheless, some of these techniques are still used to simulate the coronae and winds of solar analogs. Here we present a comparative study between two MHD models for the solar corona and solar wind. The first type of model is amore » polytropic wind model, and the second is the physics-based AWSOM model. We show that while the AWSOM model consistently reproduces many solar observations, the polytropic model fails to reproduce many of them, and in the cases where it does, its solutions are unphysical. Our recommendation is that polytropic models, which are used to estimate mass-loss rates and other parameters of solar analogs, must first be calibrated with solar observations. Alternatively, these models can be calibrated with models that capture more detailed physics of the solar corona (such as the AWSOM model) and that can reproduce solar observations in a consistent manner. Without such a calibration, the results of the polytropic models cannot be validated, but they can be wrongly used by others.« less

  8. Dynamics of Nanoparticle-Protein Corona Complex Formation: Analytical Results from Population Balance Equations

    PubMed Central

    Darabi Sahneh, Faryad; Scoglio, Caterina; Riviere, Jim

    2013-01-01

    Background Nanoparticle-protein corona complex formation involves absorption of protein molecules onto nanoparticle surfaces in a physiological environment. Understanding the corona formation process is crucial in predicting nanoparticle behavior in biological systems, including applications of nanotoxicology and development of nano drug delivery platforms. Method This paper extends the modeling work in to derive a mathematical model describing the dynamics of nanoparticle corona complex formation from population balance equations. We apply nonlinear dynamics techniques to derive analytical results for the composition of nanoparticle-protein corona complex, and validate our results through numerical simulations. Results The model presented in this paper exhibits two phases of corona complex dynamics. In the first phase, proteins rapidly bind to the free surface of nanoparticles, leading to a metastable composition. During the second phase, continuous association and dissociation of protein molecules with nanoparticles slowly changes the composition of the corona complex. Given sufficient time, composition of the corona complex reaches an equilibrium state of stable composition. We find analytical approximate formulae for metastable and stable compositions of corona complex. Our formulae are very well-structured to clearly identify important parameters determining corona composition. Conclusion The dynamics of biocorona formation constitute vital aspect of interactions between nanoparticles and living organisms. Our results further understanding of these dynamics through quantitation of experimental conditions, modeling results for in vitro systems to better predict behavior for in vivo systems. One potential application would involve a single cell culture medium related to a complex protein medium, such as blood or tissue fluid. PMID:23741371

  9. Revealing structure within the coronae of Seyfert galaxies

    NASA Astrophysics Data System (ADS)

    Wilkins, D.

    2017-10-01

    Detailed analysis of the reflection and reverberation of X-rays from the innermost regions of AGN accretion discs reveals the structure and processes that produce the intense continuum emission and the extreme variability we see, right down to the innermost stable orbit and event horizon of the black hole. Observations of Seyfert galaxies spanning more than a decade have enabled measurement of the geometry of the corona and how it evolves, leading to orders of magnitude of variability. They reveal processes the corona undergoes during transient events, notably the collimation and ejection of the corona during X-ray flares, reminiscent of the aborted launching of a jet. Recent reverberation studies, including those of the Seyfert galaxy I Zwicky 1 with XMM-Newton, are revealing structures within the corona for the first time. A persistent collimated core is found, akin to the base of a jet embedded in the innermost regions. The evolution of both the collimated and extended portions point to the mechanisms powering the X-ray emission and variability. This gives us important constraints on the processes by which energy is liberated from black hole accretion flows and by which jets are launched, allowing us to understand how these extreme objects are powered.

  10. Device for generation of pulsed corona discharge

    DOEpatents

    Gutsol, Alexander F [San Ramon, CA; Fridman, Alexander [Marlton, NJ; Blank, Kenneth [Philadelphia, PA; Korobtsev, Sergey [Moscow, RU; Shiryaevsky, Valery [Moscow, RU; Medvedev, Dmitry [Moscow, RU

    2012-05-08

    The invention is a method and system for the generation of high voltage, pulsed, periodic corona discharges capable of being used in the presence of conductive liquid droplets. The method and system can be used, for example, in different devices for cleaning of gaseous or liquid media using pulsed corona discharge. Specially designed electrodes and an inductor increase the efficiency of the system, permit the plasma chemical oxidation of detrimental impurities, and increase the range of stable discharge operations in the presence of droplets of water or other conductive liquids in the discharge chamber.

  11. Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.

    PubMed

    Jayaram, Dhanya T; Pustulka, Samantha M; Mannino, Robert G; Lam, Wilbur A; Payne, Christine K

    2018-04-09

    Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous injection and the subsequent shear flow will affect the protein corona. Our goal was to determine if shear flow changed the composition of the protein corona and if these changes affected cellular binding. Colorimetric assays of protein concentration and gel electrophoresis demonstrate that polystyrene nanoparticles subjected to flow have a greater concentration of serum proteins adsorbed on the surface, especially plasminogen. Plasminogen, in the absence of nanoparticles, undergoes changes in structure in response to flow, characterized by fluorescence and circular dichroism spectroscopy. The protein-nanoparticle complexes formed from fetal bovine serum after flow had decreased cellular binding, as measured with flow cytometry. In addition to the relevance for nanomedicine, these results also highlight the technical challenges of protein corona studies. The composition of the protein corona was highly dependent on the initial mixing step: rocking, vortexing, or flow. Overall, these results reaffirm the importance of the protein corona in nanoparticle-cell interactions and point toward the challenges of predicting corona composition based on nanoparticle properties. Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  12. Origin of coronas in metagabbros of the Adirondack mts., N. Y

    USGS Publications Warehouse

    Whitney, P.R.; McLelland, J.M.

    1973-01-01

    Metagabbros from two widely separated areas in the Adirondacks show development of coronas. In the Southern Adirondacks, these are cored by olivine which is enclosed in a shell of orthopyroxene that is partially, or completely, rimmed by symplectites consisting of clinopyroxene and spinel. Compositions of the corona phases have been determined by electron probe and are consistent with a mechanism involving three partial reactions, thus: (a) Olivine=Orthopyroxene+(Mg, Fe)++. (b) Plagioclase+(Mg, Fe)+++Ca++=Clinopyroxene+Spinel+Na+. (c) Plagioclase+(Mg, Fe)+++Na+=Spinel+more sodic plagioclase+Ca++. Reaction (a) occurs in the inner shell of the corona adjacent to olivine; reaction (b) in the outer shell; and (c) in the surrounding plagioclase, giving rise to the spinel clouding which is characteristic of the plagioclase in these rocks. Alumina and silica remain relatively immobile. These reactions, when balanced, can be generalized to account for the aluminous nature of the pyroxenes and for changing plagioclase composition. Summed together, the partial reactions are equivalent to: (d) Olivine + Anorthite = Aluminous orthopyroxene + Aluminous Clinopyroxene + Spinel (Kushiro and Yoder, 1966). In the Adirondack Highlands, coronas between olivine and plagioclase commonly have an outer shell of garnet replacing the clinopyroxene/spinel shell. The origin of the garnet can also be explained in terms of three partial reactions: (e) Orthopyroxene+Ca++=Clinopyroxene+(Mg, Fe)++. (f) Clinopyroxene+Spinel+Plagioclase+(Mg, Fe)++=Garnet+Ca+++Na+. (g) Plagioclase+(Mg, Fe)+++Na+=Spinel + more sodic plagioclase+Ca++. These occur in the inner and outer corona shell and the surrounding plagioclase, respectively, and involve the products of reactions (a)-(d). Alumina and silica are again relatively immobile. Balanced, and generalized to account for aluminous pyroxenes and variable An content of plagioclase, they are equivalent to: (h) Orthopyroxene+Anorthite+Spinel=Garnet (Green and

  13. Rings Around the Sun and Moon: Coronae and Diffraction

    ERIC Educational Resources Information Center

    Cowley, Les; Laven, Philip; Vollmer, Michael

    2005-01-01

    Atmospheric optical effects can teach much about physics and especially optics. Coronae--coloured rings around the sun or moon--are large-scale consequences of diffraction, which is often thought of as only a small effect confined to the laboratory. We describe coronae, how they are formed and experiments that can be conducted on ones in the sky.…

  14. Dynamic characteristics of corona discharge generated under rainfall condition on AC charged conductors

    NASA Astrophysics Data System (ADS)

    Xu, Pengfei; Zhang, Bo; Wang, Zezhong; Chen, Shuiming; He, Jinliang

    2017-12-01

    By synchronous measurement of corona current and the water droplet deformation process on a conductor surface, different types of corona discharge are visualized when AC voltage is applied on a line-ground electrode system. The corona characteristics are closely related to the applied voltage and water supply rate. With the increase of AC voltage, the positive Taylor cone discharge firstly appears and then disappears, replaced by the dripping and crashing discharge. Furthermore, the number of pulses in each pulse train increases with the increase of applied voltage. The mechanism of the transfer from the positive Taylor cone discharge to the dripping and crashing discharge is found to be related to the oscillation process of the water droplet. The water supply rate also has a great influence on the characteristics of corona currents. The number of positive pulse trains increases linearly when the water supply rate gets larger, leading to a higher audible noise and radio interference level from the AC corona, which is quite different from that of the DC corona. The difference between the AC and DC coronas under rainfall conditions is analyzed finally.

  15. RF multicoupler design techniques to minimize problems of corona, multipaction, and stability

    NASA Technical Reports Server (NTRS)

    Hurley, H. S.; Kozakoff, D. J.

    1971-01-01

    A mathematical expression was derived describing multipacting and corona effects in a coaxial cavity. Both mechanical and electrical design techniques were investigated to minimize the susceptibility of coaxial cavity to corona and multipacting-type breakdown. To assist in the design of a multicoupler free from corona and multipactor breakdown, a flow chart obtained from the derived mathematical expression is included.

  16. Corona from Ice, Thunderstorm Electrification and Lightning Suppression.

    DTIC Science & Technology

    1980-11-01

    rates of droplets highly charged by interaction with corona streamers. Laboratory and theoretical studies have been performed in an effort to explore in...CORONA FROM ICE, THUNDERSTORM ELECTRIFICATION Final AND LIGHTNING SUPPRESSION 1 Sep 77 to 31 Aug 80 6. Performing Org. Report Number 7. Author(s) 8...Contract or Grant Number J. Latham AFOSR-77-3429 O"o 9. Performing Organization Name and Address 10. Program Element, Project, Task Physics Department

  17. Discovering structure and evolution within the coronae of Seyfert galaxies

    NASA Astrophysics Data System (ADS)

    Wilkins, Daniel; Gallo, Luigi C.; Silva, Catia; Costantini, Elisa

    2017-08-01

    Detailed analysis of the reflection and reverberation of X-rays from the innermost regions of AGN accretion discs reveals the structure and processes that produce the intense continuum emission and the extreme variability we see, right down to the innermost stable orbit and event horizon of the black hole. Observations of Seyfert galaxies spanning more than a decade have enabled measurement of the geometry of the corona and how it evolves, leading to orders of magnitude in variability. They reveal processes the corona undergoes during transient events, notably the collimation and ejection of the corona during X-ray flares, reminiscent of the aborted launching of a jet.Recent reverberation studies, of the Seyfert galaxy I Zwicky 1 with XMM-Newton, are revealing structures within the corona for the very first time. A persistent collimated core is discovered, akin to the base of a jet embedded in the innermost regions alongside an extended corona related to the accretion disc. The detection of the flare in the X-ray emission enables the evolution of both the collimated and extended portions of the corona to be tracked. The flare is seen originating as an increase in activity above the accretion disc before propagating inwards, energising the collimated core at a later time, leading to a second sharp increase in the X-ray luminosity.This gives us important constraints on the processes by which energy is liberated from black hole accretion flows, how they are governed over time and how jets are launched, giving us the deepest insight to date of how these extreme objects are powered.

  18. MASC: Magnetic Activity of the Solar Corona

    NASA Astrophysics Data System (ADS)

    Auchere, Frederic; Fineschi, Silvano; Gan, Weiqun; Peter, Hardi; Vial, Jean-Claude; Zhukov, Andrei; Parenti, Susanna; Li, Hui; Romoli, Marco

    We present MASC, an innovative payload designed to explore the magnetic activity of the solar corona. It is composed of three complementary instruments: a Hard-X-ray spectrometer, a UV / EUV imager, and a Visible Light / UV polarimetric coronagraph able to measure the coronal magnetic field. The solar corona is structured in magnetically closed and open structures from which slow and fast solar winds are respectively released. In spite of much progress brought by two decades of almost uninterrupted observations from several space missions, the sources and acceleration mechanisms of both types are still not understood. This continuous expansion of the solar atmosphere is disturbed by sporadic but frequent and violent events. Coronal mass ejections (CMEs) are large-scale massive eruptions of magnetic structures out of the corona, while solar flares trace the sudden heating of coronal plasma and the acceleration of electrons and ions to high, sometimes relativistic, energies. Both phenomena are most probably driven by instabilities of the magnetic field in the corona. The relations between flares and CMEs are still not understood in terms of initiation and energy partition between large-scale motions, small-scale heating and particle acceleration. The initiation is probably related to magnetic reconnection which itself results magnetic topological changes due to e.g. flux emergence, footpoints motions, etc. Acceleration and heating are also strongly coupled since the atmospheric heating is thought to result from the impact of accelerated particles. The measurement of both physical processes and their outputs is consequently of major importance. However, despite its fundamental importance as a driver for the physics of the Sun and of the heliosphere, the magnetic field of our star’s outer atmosphere remains poorly understood. This is due in large part to the fact that the magnetic field is a very difficult quantity to measure. Our knowledge of its strength and

  19. Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake.

    PubMed

    Mirshafiee, Vahid; Kim, Raehyun; Park, Soyun; Mahmoudi, Morteza; Kraft, Mary L

    2016-01-01

    Nanoparticles (NPs) are functionalized with targeting ligands to enable selectively delivering drugs to desired locations in the body. When these functionalized NPs enter the blood stream, plasma proteins bind to their surfaces, forming a protein corona that affects NP uptake and targeting efficiency. To address this problem, new strategies for directing the formation of a protein corona that has targeting capabilities are emerging. Here, we have investigated the feasibility of directing corona composition to promote targeted NP uptake by specific types of cells. We used the well-characterized process of opsonin-induced phagocytosis by macrophages as a simplified model of corona-mediated NP uptake by a desired cell type. We demonstrate that pre-coating silica NPs with gamma-globulins (γ-globulins) produced a protein corona that was enriched with opsonins, such as immunoglobulins. Although immunoglobulins are ligands that bind to receptors on macrophages and elicit phagocytois, the opsonin-rich protein corona did not increase NP uptake by macrophage RAW 264.7 cells. Immunolabeling experiments indicated that the binding of opsonins to their target cell surface receptors was impeded by other proteins in the corona. Thus, corona-mediated NP targeting strategies must optimize both the recruitment of the desired plasma proteins as well as their accessibility and orientation in the corona layer. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Effect of corona discharge on cadmium sulphide and lead sulphide films

    NASA Astrophysics Data System (ADS)

    Koul Chaku, Anemone; Singh, Pramod K.; Bhattacharya, Bhaskar

    2018-03-01

    This paper describes the effect of corona discharge on cadmium sulphide (CdS) and lead sulphide (PbS) films prepared using the chemical route. The property of films before and after exposure to corona has been described in detail. The electronic properties of the CdS and PbS films have been studied by current-voltage (I-V), capacitance-voltage (C-V) measurements. The structural properties and surface morphology were studied by using X-ray diffraction and scanning electron microscopy before and after exposing to Corona discharge. The films displayed the change in surface morphology after exposure to the corona discharge. It has been found that the films showed an increase in resistivity after exposure. This change in property has been attributed to modification in surface states. Time-dependent recovery indicated that room temperature annealing is sufficient to regain the normal resistivity of the films. The experiment was carried with the aim of studying the effect of the interaction of corona discharge on the semiconductor films and its subsequent effects.

  1. Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles.

    PubMed

    Li, Yang; Monteiro-Riviere, Nancy A

    2016-12-01

    To assess inflammation, cellular uptake and endocytic mechanisms of gold nanoparticles (AuNP) in human epidermal keratinocytes with and without a protein corona. Human epidermal keratinocytes were exposed to 40 and 80 nm AuNP with lipoic acid, polyethylene glycol (PEG) and branched polyethyleneimine (BPEI) coatings with and without a protein corona up to 48 h. Inhibitors were selected to characterize endocytosis. BPEI-AuNP showed the greatest uptake, while PEG-AuNP had the least. Protein coronas decreased uptake and affected their mechanism. AuNP uptake was energy-dependent, except for 40 nm lipoic-AuNP. Most AuNP were internalized by clathrin and lipid raft-mediated endocytosis, except for 40 nm PEG was by raft/noncaveolae mediated endocytosis. Coronas inhibited caveolae-mediated-endocytosis with lipoic acid and BPEI-AuNP and altered 40 nm PEG-AuNP from raft/noncaveolae to clathrin. Inflammatory responses decreased with a plasma corona. Results suggest protein coronas significantly affect cellular uptake and inflammatory responses of AuNP.

  2. Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona.

    PubMed

    Saha, Krishnendu; Rahimi, Mehran; Yazdani, Mahdieh; Kim, Sung Tae; Moyano, Daniel F; Hou, Singyuk; Das, Ridhha; Mout, Rubul; Rezaee, Farhad; Mahmoudi, Morteza; Rotello, Vincent M

    2016-04-26

    Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.

  3. Multiscale simulation of DC corona discharge and ozone generation from nanostructures

    NASA Astrophysics Data System (ADS)

    Wang, Pengxiang

    Atmospheric direct current (dc) corona discharge from micro-sized objects has been widely used as an ion source in many devices, such as photocopiers, laser printers, and electronic air cleaners. Shrinking the size of the discharge electrode to the nanometer range (e.g., through the use of carbon nanotubes or CNTs) is expected to lead to a significant reduction in power consumption and detrimental ozone production in these devices. The objectives of this study are to unveil the fundamental physics of the nanoscale corona discharge and to evaluate its performance and ozone production through numerical models. The extremely small size of CNTs presents considerable complexity and challenges in modeling CNT corona discharges. A hybrid multiscale model, which combines a kinetic particle-in-cell plus Monte Carlo collision (PIC-MCC) model and a continuum model, is developed to simulate the corona discharge from nanostructures. The multiscale model is developed in several steps. First, a pure PIC-MCC model is developed and PIC-MCC simulations of corona plasma from micro-sized electrode with same boundary conditions as prior model are performed to validate the PIC-MCC scheme. The agreement between the PIC-MCC model and the prior continuum model indicates the validity of the PIC-MCC scheme. The validated PIC-MCC scheme is then coupled with a continuum model to simulate the corona discharge from a micro-sized electrode. Unlike the prior continuum model which only predicts the corona plasma region, the hybrid model successfully predicts the self-consistent discharge process in the entire corona discharge gap that includes both corona plasma region and unipolar ion region. The voltage-current density curves obtained by the hybrid model agree well with analytical prediction and experimental results. The hybrid modeling approach, which combines the accuracy of a kinetic model and the efficiency of a continuum model, is thus validated for modeling dc corona discharges. For

  4. Coronas-F Orbit Monitoring and Re-Entry Prediction

    NASA Technical Reports Server (NTRS)

    Ivanov, N. M.; Kolyuka, Yu. F.; Afanasieva, T. I.; Gridchina, T. A.

    2007-01-01

    Russian scientific satellite CORONAS-F was launched on July, 31, 2001. The object was inserted in near-circular orbit with the inclination 82.5deg and a mean altitude approx. 520 km. Due to the upper atmosphere drag CORONAS-F was permanently descended and as a result on December, 6, 2005 it has finished the earth-orbital flight, having lifetime in space approx. 4.5 years. The satellite structural features and its flight attitude control led to the significant variations of its ballistic coefficient during the flight. It was a cause of some specific difficulties in the fulfillment of the ballistic and navigation support of this space vehicle flight. Besides the main mission objective CORONAS-F also has been selected by the Inter-Agency Space Debris Coordination Committee (IADC) as a target object for the next regular international re-entry test campaign on a program of surveillance and re-entry prediction for the hazard space objects within their de-orbiting phases. Spacecraft (S/C) CORONAS-F kept its working state right up to the end of the flight - down to the atmosphere entry. This fact enabled to realization of the additional research experiments, concerning with an estimation of the atmospheric density within the low earth orbits (LEO) of the artificial satellites, and made possible to continue track the S/C during final phase of its flight by means of Russian regular command & tracking system, used for it control. Thus there appeared a unique possibility of using for tracking S/C at its de-orbiting phase not only passive radar facilities, belonging to the space surveillance systems and traditionally used for support of the IADC re-entry test campaigns, but also more precise active trajectory radio-tracking facilities from the ground control complex (GCC) applied for this object. Under the corresponding decision of the Russian side such capability of additional high-precise tracking control of the CORONAS-F flight in this period of time has been implemented

  5. Atmospheric negative corona discharge using a Taylor cone as liquid electrode

    NASA Astrophysics Data System (ADS)

    Sekine, Ryuto; Shirai, Naoki; Uchida, Satoshi; Tochikubo, Fumiyoshi

    2012-10-01

    We examined characteristics of atmospheric negative corona discharge using liquid needle cathode. As a liquid needle cathode, we adopted Taylor cone with conical shape. A nozzle with inner diameter of 10 mm is filled with liquid, and a plate electrode is placed at 10 mm above the nozzle. By applying a dc voltage between electrodes, Taylor cone is formed. To change the liquid property, we added sodium dodecyl sulfate to reduce the surface tension, sodium sulfate to increase the conductivity, and polyvinyl alcohol to increase the viscosity, in distilled water. The liquid, with high surface tension such as pure water could not form a Taylor cone. When we reduced surface tension, a Taylor cone was formed and the stable corona discharge was observed at the tip of the cone. When we increased viscosity, a liquid filament protruded from the solution surface was formed and corona discharge was observed along the filament at position 0.7-1.0 mm above from the tip of the cone. Increasing the conductivity resulted in the higher light intensity of corona and the lower corona onset voltage. When we use the metal needle electrode, the corona discharge depends on the voltage and the gap length. Using Taylor cone, different types of discharges were observed by changing the property of the liquid.

  6. The effects of corona on current surges induced on conducting lines by EMP: A comparison of experiment data with results of analytic corona models

    NASA Astrophysics Data System (ADS)

    Blanchard, J. P.; Tesche, F. M.; McConnell, B. W.

    1987-09-01

    An experiment to determine the interaction of an intense electromagnetic pulse (EMP), such as that produced by a nuclear detonation above the Earth's atmosphere, was performed in March, 1986 at Kirtland Air Force Base near Albuquerque, New Mexico. The results of that experiment have been published without analysis. Following an introduction of the corona phenomenon, the reason for interest in it, and a review of the experiment, this paper discusses five different analytic corona models that may model corona formation on a conducting line subjected to EMP. The results predicted by these models are compared with measured data acquired during the experiment to determine the strengths and weaknesses of each model.

  7. Dimensions of Attention Associated With the Microstructure of Corona Radiata White Matter.

    PubMed

    Stave, Elise A; De Bellis, Michael D; Hooper, Steven R; Woolley, Donald P; Chang, Suk Ki; Chen, Steven D

    2017-04-01

    Mirsky proposed a model of attention that included these dimensions: focus/execute, sustain, stabilize, encode, and shift. The neural correlates of these dimensions were investigated within corona radiata subregions in healthy youth. Diffusion tensor imaging and neuropsychological assessments were conducted in 79 healthy, right-handed youth aged 4-17 years. Diffusion tensor imaging maps were analyzed using standardized parcellation methods. Partial Pearson correlations between neuropsychological standardized scores, representing these attention dimensions, and diffusion tensor imaging measures of corona radiata subregions were calculated after adjusting for gender and IQ. Significant correlations were found between the focus/execute, sustain, stabilize, and shift dimensions and imaging metrics in hypothesized corona radiata subregions. Results suggest that greater microstructural white matter integrity of the corona radiata is partly associated with attention across 4 attention dimensions. Findings suggest that white matter microstructure of the corona radiata is a neural correlate of several, but not all, attention dimensions.

  8. Analysis of counter flow of corona wind for heat transfer enhancement

    NASA Astrophysics Data System (ADS)

    Shin, Dong Ho; Baek, Soo Hong; Ko, Han Seo

    2018-03-01

    A heat sink for cooling devices using the counter flow of a corona wind was developed in this study. Detailed information about the numerical investigations of forced convection using the corona wind was presented. The fins of the heat sink using the counter flow of a corona wind were also investigated. The corona wind generator with a wire-to-plate electrode arrangement was used for generating the counter flow to the fin. The compact and simple geometric characteristics of the corona wind generator facilitate the application of the heat sink using the counter flow, demonstrating the heat sink is effective for cooling electronic devices. Parametric studies were performed to analyze the effect of the counter flow on the fins. Also, the velocity and temperature were measured experimentally for the test mock-up of the heat sink with the corona wind generator to verify the numerical results. From a numerical study, the type of fin and its optimal height, length, and pitch were suggested for various heat fluxes. In addition, the correlations to calculate the mass of the developed heat sink and its cooling performance in terms of the heat transfer coefficient were derived. Finally, the cooling efficiencies corresponding to the mass, applied power, total size, and noise of the devices were compared with the existing commercial central processing unit (CPU) cooling devices with rotor fans. As a result, it was confirmed that the heat sink using the counter flow of the corona wind showed appropriate efficiencies for cooling electronic devices, and is a suitable replacement for the existing cooling device for high power electronics.

  9. Micro Corona Ionizer as an Ozone Source for Bacterial Cell Lysis

    NASA Astrophysics Data System (ADS)

    Lee, Eun-Hee; Lim, Hyun Jeong; Chua, Beelee; Son, Ahjeong

    2015-04-01

    DNA extraction is a critical process of DNA assays including polymerase chain reaction (PCR), microarrays, molecular cloning, and DNA hybridization which has been well established and can be implemented by commercial kits. DNA extraction involves cell lysis, precipitation, and purification through the combination of physical and chemical processes. Cell lysis is essential to high DNA recovery yield which can be achieved via a variety of physical, chemical, and enzymatic methods. However, these methods were originally developed for bioassays that were labor intensive, time consuming, and vulnerable to contamination and inhibition. Here, we proposed to employ a micro corona ionizer as an ozone source to lyse bacterial cells. Ozone has been well known and used as a disinfectant which allows cell lysis and DNA extraction. Previously, we have shown that a micro corona ionizer is capable of generating a significant amount of ozone. In this study, we employed the micro corona ionizer for the bacterial cell lysis which consists of a 50 μm diameter cantilever wire as the discharge cathode and a 50 μm thick copper foil as anode. Applied voltages varied from 1900 to 2200 V with corresponding corona currents from 16 to 28 μA. The resultant ozone (concentration > 0.14 ppm) generated from the micro corona ionizer was bubbled into the sample via a miniature pump. We demonstrated the cell lysis of Pseudomonas putida as the target bacterium using the micro corona ionizer. At a flow rate of 38 ml/min and applied corona voltage of 2000 V, 98.5 ± 0.2% lysis (normalized to sonication result) was achieved after 10 min. In comparison, untreated and air-treated samples showed normalized % lysis of 11.9 ± 2.4 and 36.1 ± 1.7%, respectively. We also showed that the cell lysis efficiency could be significantly increased by increasing the flow rate and the applied corona voltage. By comparing the experimental results for continuous and pulsed treatment, we verified that the percentage of

  10. Viscoelastic Relaxation of Topographic Highs on Venus to Produce Coronae

    NASA Technical Reports Server (NTRS)

    Janes, Daniel M.; Squyres, Steven W.

    1995-01-01

    Coronae on Venus are believed to result from the gravitationally driven relaxation of topography that was originally raised by mantle diapirs. We examine this relaxation using a viscoelastic finite element code, and show that an initially plateau shaped load will evolve to the characteristic corona topography of central raised bowl, annular rim, and surrounding moat. Stresses induced by the relaxation are consistent with the development of concentric extensional fracturing common on the outer margins of corona moats. However, relaxation is not expected to produce the concentric faulting often observed on the annular rim. The relaxation timescale is shorter than the diapir cooling timescale, so loss of thermal support controls the rate at which topography is reduced. The final corona shape is supported by buoyancy and flexural stresses and will persist through geologic time. Development of lower, flatter central bowls and narrower and more pronounced annular rims and moats enhanced by thicker crusts, higher thermal gradients, and crustal thinning over the diapir.

  11. Electric-Field Instrument With Ac-Biased Corona Point

    NASA Technical Reports Server (NTRS)

    Markson, R.; Anderson, B.; Govaert, J.

    1993-01-01

    Measurements indicative of incipient lightning yield additional information. New instrument gives reliable readings. High-voltage ac bias applied to needle point through high-resistance capacitance network provides corona discharge at all times, enabling more-slowly-varying component of electrostatic potential of needle to come to equilibrium with surrounding air. High resistance of high-voltage coupling makes instrument insensitive to wind. Improved corona-point instrument expected to yield additional information assisting in safety-oriented forecasting of lighting.

  12. LABORATORY ANALYSES OF CORONA DISCHARGES

    EPA Science Inventory

    The paper discusses an experimental research program to characterize corona generation from different electrode geometries in a range of conditions comparable to those found in electrostatic precipitators (ESPs). A wire-parallel plate device and a wire-cylinder device were used t...

  13. Propagation characteristics of audible noise generated by single corona source under positive DC voltage

    NASA Astrophysics Data System (ADS)

    Li, Xuebao; Cui, Xiang; Lu, Tiebing; Wang, Donglai

    2017-10-01

    The directivity and lateral profile of corona-generated audible noise (AN) from a single corona source are measured through experiments carried out in the semi-anechoic laboratory. The experimental results show that the waveform of corona-generated AN consists of a series of random sound pressure pulses whose pulse amplitudes decrease with the increase of measurement distance. A single corona source can be regarded as a non-directional AN source, and the A-weighted SPL (sound pressure level) decreases 6 dB(A) as doubling the measurement distance. Then, qualitative explanations for the rationality of treating the single corona source as a point source are given on the basis of the Ingard's theory for sound generation in corona discharge. Furthermore, we take into consideration of the ground reflection and the air attenuation to reconstruct the propagation features of AN from the single corona source. The calculated results agree with the measurement well, which validates the propagation model. Finally, the influence of the ground reflection on the SPL is presented in the paper.

  14. The Role of Magnetic Helicity in Structuring the Solar Corona

    NASA Technical Reports Server (NTRS)

    Knizhnik, K. J.; Antiochos, S. K.; DeVore, C. R.

    2017-01-01

    Two of the most widely observed and striking features of the Suns magnetic field are coronal loops, which are smooth and laminar, and prominences or filaments, which are strongly sheared. Loops are puzzling because they show little evidence of tangling or braiding, at least on the quiet Sun, despite the chaotic nature of the solar surface convection. Prominences are mysterious because the origin of their underlying magnetic structure filament channels is poorly understood at best. These two types of features would seem to be quite unrelated and wholly distinct. We argue that, on the contrary, they are inextricably linked and result from a single process: the injection of magnetic helicity into the corona by photospheric motions and the subsequent evolution of this helicity by coronal reconnection. In this paper, we present numerical simulations of the response of a Parker (1972) corona to photospheric driving motions that have varying degrees of helicity preference. We obtain four main conclusions: (1) in agreement with the helicity condensation model of Antiochos (2013), the inverse cascade of helicity by magnetic reconnection in the corona results in the formation of filament channels localized about polarity inversion lines; (2) this same process removes most complex fine structure from the rest of the corona, resulting in smooth and laminar coronal loops; (3) the amount of remnant tangling in coronal loops is inversely dependent on the net helicity injected by the driving motions; and (4) the structure of the solar corona depends only on the helicity preference of the driving motions and not on their detailed time dependence. We discuss the implications of our results for high-resolution observations of the corona.

  15. THE ROLE OF MAGNETIC HELICITY IN STRUCTURING THE SOLAR CORONA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Knizhnik, K. J.; Antiochos, S. K.; DeVore, C. R.

    Two of the most widely observed and striking features of the Sun's magnetic field are coronal loops, which are smooth and laminar, and prominences or filaments, which are strongly sheared. Loops are puzzling because they show little evidence of tangling or braiding, at least on the quiet Sun, despite the chaotic nature of the solar surface convection. Prominences are mysterious because the origin of their underlying magnetic structure—filament channels—is poorly understood at best. These two types of features would seem to be quite unrelated and wholly distinct. We argue that, on the contrary, they are inextricably linked and result frommore » a single process: the injection of magnetic helicity into the corona by photospheric motions and the subsequent evolution of this helicity by coronal reconnection. In this paper, we present numerical simulations of the response of a Parker (1972) corona to photospheric driving motions that have varying degrees of helicity preference. We obtain four main conclusions: (1) in agreement with the helicity condensation model of Antiochos (2013), the inverse cascade of helicity by magnetic reconnection in the corona results in the formation of filament channels localized about polarity inversion lines; (2) this same process removes most complex fine structure from the rest of the corona, resulting in smooth and laminar coronal loops; (3) the amount of remnant tangling in coronal loops is inversely dependent on the net helicity injected by the driving motions; and (4) the structure of the solar corona depends only on the helicity preference of the driving motions and not on their detailed time dependence. We discuss the implications of our results for high-resolution observations of the corona.« less

  16. A study of acoustic heating and forced convection in the solar corona

    NASA Technical Reports Server (NTRS)

    Foukal, P. V.

    1980-01-01

    The S055 EUV spectra was used to perform emission measure and line intensity ratio analyses of loop plasma conditions in a study on the thermodynamics of magnetic loops in the solar corona. The evidence that loops contain plasma hotter than the background corona, and thus, require enhanced local dissipation of magnetic or mechanical energy is discussed. The S055 EUV raster pictures were used to study physical conditions in cool ultraviolet absorbing clouds in the solar corona, and optical data were used to derive constraints on the dimension, time scales and optical depths in dark opaque clouds not seen in H alpha and CaK as filaments or prominences. Theoretical modelling of propagation of magnetically guided acoustic shocks in the solar chromosphere finds it still unlikely that high frequency acoustic shocks could reach the solar corona. Dynamic modelling of spicules shows that such guided slow mode shocks can explain the acceleration of cool spicular material seen high in the corona.

  17. Dimensions of Attention Associated with the Microstructure of Corona Radiata White Matter

    PubMed Central

    Stave, Elise A.; Hooper, Stephen R.; Woolley, Donald P.; Chang, Suk Ki; Chen, Steven D.

    2016-01-01

    Mirsky proposed a model of attention that included these dimensions: focus/execute, sustain, stabilize, encode, and shift. The neural correlates of these dimensions were investigated within corona radiate subregions in healthy youth. Diffusion tensor imaging and neuropsychological assessments were conducted in 79 healthy, right-handed youth aged 4–17 years. Diffusion tensor imaging maps were analyzed using standardized parcellation methods. Partial Pearson correlations between neuropsychological standardized scores, representing these attention dimensions, and diffusion tensor imaging measures of corona radiate subregions were calculated after adjusting for gender and IQ. Significant correlations were found between the focus/execute, sustain, stabilize and shift dimensions and imaging metrics in hypothesized corona radiate subregions. Results suggest that greater microstructural white matter integrity of the corona radiata is partly associated with attention across four attention dimensions. Findings suggest that white matter microstructure of the corona radiata is a neural correlate of several, but not all, attention dimensions. PMID:28090797

  18. Heating of the corona by magnetic singularities

    NASA Technical Reports Server (NTRS)

    Antiochos, Spiro K.

    1990-01-01

    Theoretical models of current-sheet formation and magnetic heating in the solar corona are examined analytically. The role of photospheric connectivity in determining the topology of the coronal magnetic field and its equilibrium properties is explored; nonequilibrium models of current-sheet formation (assuming an initially well connected field) are described; and particular attention is given to models with discontinuous connectivity, where magnetic singularities arise from smooth footpoint motions. It is shown that current sheets arise from connectivities in which the photospheric flux structure is complex, with three or more polarity regions and a magnetic null point within the corona.

  19. Hard X-ray emission from the solar corona

    NASA Astrophysics Data System (ADS)

    Krucker, S.; Battaglia, M.; Cargill, P. J.; Fletcher, L.; Hudson, H. S.; MacKinnon, A. L.; Masuda, S.; Sui, L.; Tomczak, M.; Veronig, A. L.; Vlahos, L.; White, S. M.

    2008-10-01

    This review surveys hard X-ray emissions of non-thermal electrons in the solar corona. These electrons originate in flares and flare-related processes. Hard X-ray emission is the most direct diagnostic of electron presence in the corona, and such observations provide quantitative determinations of the total energy in the non-thermal electrons. The most intense flare emissions are generally observed from the chromosphere at footpoints of magnetic loops. Over the years, however, many observations of hard X-ray and even γ-ray emission directly from the corona have also been reported. These coronal sources are of particular interest as they occur closest to where the electron acceleration is thought to occur. Prior to the actual direct imaging observations, disk occultation was usually required to study coronal sources, resulting in limited physical information. Now RHESSI has given us a systematic view of coronal sources that combines high spatial and spectral resolution with broad energy coverage and high sensitivity. Despite the low density and hence low bremsstrahlung efficiency of the corona, we now detect coronal hard X-ray emissions from sources in all phases of solar flares. Because the physical conditions in such sources may differ substantially from those of the usual “footpoint” emission regions, we take the opportunity to revisit the physics of hard X-radiation and relevant theories of particle acceleration.

  20. Electrode structure for uniform corona discharge

    NASA Technical Reports Server (NTRS)

    Gange, R. A.; Steinmetz, C. C.

    1976-01-01

    Single corona-discharge needle is used to apply uniform charge to thermoplastic medium in holograph-storage system. Needle is connected to flat transparent electrode that is parallel to thermoplastic.

  1. Digging into the corona: A modeling framework trained with Sun-grazing comet observations

    NASA Astrophysics Data System (ADS)

    Jia, Y. D.; Pesnell, W. D.; Bryans, P.; Downs, C.; Liu, W.; Schwartz, S. J.

    2017-12-01

    Images of comets diving into the low corona have been captured a few times in the past decade. Structures visible at various wavelengths during these encounters indicate a strong variation of the ambient conditions of the corona. We combine three numerical models: a global coronal model, a particle transportation model, and a cometary plasma interaction model into one framework to model the interaction of such Sun-grazing comets with plasma in the low corona. In our framework, cometary vapors are ionized via multiple channels and then captured by the coronal magnetic field. In seconds, these ions are further ionized into their highest charge state, which is revealed by certain coronal emission lines. Constrained by observations, we apply our framework to trace back to the local conditions of the ambient corona, and their spatial/time variation over a broad range of scales. Once trained by multiple stages of the comet's journey in the low corona, we illustrate how this framework can leverage these unique observations to probe the structure of the solar corona and solar wind.

  2. Surface chemistry and serum type both determine the nanoparticle-protein corona.

    PubMed

    Pozzi, Daniela; Caracciolo, Giulio; Capriotti, Anna Laura; Cavaliere, Chiara; La Barbera, Giorgia; Anchordoquy, Thomas J; Laganà, Aldo

    2015-04-24

    The protein corona that forms around nanoparticles in vivo is a critical factor that affects their physiological response. The potential to manipulate nanoparticle characteristics such that either proteins advantageous for delivery are recruited and/or detrimental proteins are avoided offers exciting possibilities for improving drug delivery. In this work, we used nanoliquid chromatography tandem mass spectrometry to characterize the corona of five lipid formulations after incubation in mouse and human plasma with the hope of providing data that may contribute to a better understanding of the role played by both the nanoparticle properties and the physiological environment in recruiting specific proteins to the corona. Notably, we showed that minor changes in the lipid composition might critically affect the protein corona composition demonstrating that the surface chemistry and arrangement of lipid functional groups are key players that regulate the liposome-protein interactions. Notably, we provided evidence that the protein corona that forms around liposomes is strongly affected by the physiological environment, i.e., the serum type. These results are likely to suggest that the translation of novel pharmaceutical formulations from animal models to the clinic must be evaluated on a case-by-case basis. In the present work nanoliquid chromatography tandem mass spectrometry was used to characterize the protein corona of five different liposome formulations after exposure to mouse and human plasma. The modern proteomic methods employed have clarified that the arrangement of lipid functional groups is a key player that regulates the liposome-protein interactions. We also clarified that the protein corona enrichment and complexity depend on the serum type. Our results suggest that the translational of novel pharmaceutical formulations from animal models to the clinic must be evaluated on a case-by-case basis. Copyright © 2015. Published by Elsevier B.V.

  3. Revisiting the positive DC corona discharge theory: Beyond Peek's and Townsend's law

    NASA Astrophysics Data System (ADS)

    Monrolin, Nicolas; Praud, Olivier; Plouraboué, Franck

    2018-06-01

    The classical positive Corona Discharge theory in a cylindrical axisymmetric configuration is revisited in order to find analytically the influence of gas properties and thermodynamic conditions on the corona current. The matched asymptotic expansion of Durbin and Turyn [J. Phys. D: Appl. Phys. 20, 1490-1495 (1987)] of a simplified but self-consistent problem is performed and explicit analytical solutions are derived. The mathematical derivation enables us to express a new positive DC corona current-voltage characteristic, choosing either a dimensionless or dimensional formulation. In dimensional variables, the current voltage law and the corona inception voltage explicitly depend on the electrode size and physical gas properties such as ionization and photoionization parameters. The analytical predictions are successfully confronted with experiments and Peek's and Townsend's laws. An analytical expression of the corona inception voltage φ o n is proposed, which depends on the known values of physical parameters without adjustable parameters. As a proof of consistency, the classical Townsend current-voltage law I = C φ ( φ - φ o n ) is retrieved by linearizing the non-dimensional analytical solution. A brief parametric study showcases the interest in this analytical current model, especially for exploring small corona wires or considering various thermodynamic conditions.

  4. Stable structures of microparticles in the electrodynamic trap created by the corona discharge

    NASA Astrophysics Data System (ADS)

    Vladimirov, V. I.; Deputatova, L. V.; Filinov, V. S.; Lapitsky, D. S.; Pecherkin, V. Ya; Syrovatka, R. A.; Vasilyak, L. M.; Petrov, O. F.

    2018-01-01

    For the first time the stable structures of microparticles in a dynamic linear trap with corona electrodes have been obtained. The possibility for capturing and confining of microparticles in a linear electrodynamic trap with corona electrodes at atmospheric pressure has been studied experimentally. The corona discharge on the electrodes of the trap was generated by an alternating electric field.

  5. Dispersion of Nanoparticles in Different Media Importantly Determines the Composition of Their Protein Corona.

    PubMed

    Strojan, Klemen; Leonardi, Adrijana; Bregar, Vladimir B; Križaj, Igor; Svete, Jurij; Pavlin, Mojca

    2017-01-01

    Protein corona of nanoparticles (NPs), which forms when these particles come in to contact with protein-containing fluids, is considered as an overlooked factor in nanomedicine. Through numerous studies it has been becoming increasingly evident that it importantly dictates the interaction of NPs with their surroundings. Several factors that determine the compositions of NPs protein corona have been identified in recent years, but one has remained largely ignored-the composition of media used for dispersion of NPs. Here, we determined the effect of dispersion media on the composition of protein corona of polyacrylic acid-coated cobalt ferrite NPs (PAA NPs) and silica NPs. Our results confirmed some of the basic premises such as NPs type-dependent specificity of the protein corona. But more importantly, we demonstrated the effect of the dispersion media on the protein corona composition. The differences between constituents of the media used for dispersion of NPs, such as divalent ions and macromolecules were responsible for the differences in protein corona composition formed in the presence of fetal bovine serum (FBS). Our results suggest that the protein corona composition is a complex function of the constituents present in the media used for dispersion of NPs. Regardless of the dispersion media and FBS concentration, majority of proteins from either PAA NPs or silica NPs coronas were involved in the process of transport and hemostasis. Interestingly, corona of silica NPs contained three complement system related proteins: complement factor H, complement C3 and complement C4 while PAA NPs bound only one immune system related protein, α-2-glycoprotein. Importantly, relative abundance of complement C3 protein in corona of silica NPs was increased when NPs were dispersed in NaCl, which further implies the relevance of dispersion media used to prepare NPs.

  6. Dispersion of Nanoparticles in Different Media Importantly Determines the Composition of Their Protein Corona

    PubMed Central

    Strojan, Klemen; Leonardi, Adrijana; Bregar, Vladimir B.; Križaj, Igor; Svete, Jurij; Pavlin, Mojca

    2017-01-01

    Protein corona of nanoparticles (NPs), which forms when these particles come in to contact with protein-containing fluids, is considered as an overlooked factor in nanomedicine. Through numerous studies it has been becoming increasingly evident that it importantly dictates the interaction of NPs with their surroundings. Several factors that determine the compositions of NPs protein corona have been identified in recent years, but one has remained largely ignored—the composition of media used for dispersion of NPs. Here, we determined the effect of dispersion media on the composition of protein corona of polyacrylic acid-coated cobalt ferrite NPs (PAA NPs) and silica NPs. Our results confirmed some of the basic premises such as NPs type-dependent specificity of the protein corona. But more importantly, we demonstrated the effect of the dispersion media on the protein corona composition. The differences between constituents of the media used for dispersion of NPs, such as divalent ions and macromolecules were responsible for the differences in protein corona composition formed in the presence of fetal bovine serum (FBS). Our results suggest that the protein corona composition is a complex function of the constituents present in the media used for dispersion of NPs. Regardless of the dispersion media and FBS concentration, majority of proteins from either PAA NPs or silica NPs coronas were involved in the process of transport and hemostasis. Interestingly, corona of silica NPs contained three complement system related proteins: complement factor H, complement C3 and complement C4 while PAA NPs bound only one immune system related protein, α-2-glycoprotein. Importantly, relative abundance of complement C3 protein in corona of silica NPs was increased when NPs were dispersed in NaCl, which further implies the relevance of dispersion media used to prepare NPs. PMID:28052135

  7. Predicting success of methotrexate treatment by pretreatment HCG level and 24-hour HCG increment.

    PubMed

    Levin, Gabriel; Saleh, Narjes A; Haj-Yahya, Rani; Matan, Liat S; Avi, Benshushan

    2018-04-01

    To evaluate β-human chorionic gonadotropin (β-HCG) level and its 24-hour increment as predictors of successful methotrexate treatment for ectopic pregnancy. Data were retrospectively reviewed from women with ectopic pregnancy who were treated by single-dose methotrexate (50 mg/m 2 ) at a university hospital in Jerusalem, Israel, between January 1, 2000, and June 30, 2015. Serum β-HCG before treatment and its percentage increment in the 24 hours before treatment were compared between treatment success and failure groups. Sixty-nine women were included in the study. Single-dose methotrexate treatment was successful for 44 (63.8%) women. Both mean β-HCG level and its 24-hour increment were lower for women with successful treatment than for those with failed treatment (respectively, 1224 IU\\L vs 2362 IU\\L, P=0.018; and 13.5% vs 29.6%, P=0.009). Receiver operator characteristic curve analysis yielded cutoff values of 1600 IU\\L and 14% increment with a positive predictive value of 75% and 82%, respectively, for treatment success. β-HCG level and its 24-hour increment were independent predictors of treatment outcome by logistic regression (both P<0.01). A β-HCG increment of less than 14% in the 24 hours before single-dose methotrexate and serum β-HCG of less than 1600 IU\\L were found to be good predictors of treatment success. © 2017 International Federation of Gynecology and Obstetrics.

  8. Experimental Investigation of the Induced Airflow of Corona Discharge

    NASA Astrophysics Data System (ADS)

    Huang, Yong; Zhang, Xin; Wang, Xun-Nian; Wang, Wan-Bo; Huang, Zong-Bo; Li, Hua-Xing

    2013-09-01

    In order to improve the acceleration effect of corona discharge acting on air, we present an experimental study on the induced airflow produced by corona discharge between two parallel electrodes. The parameters investigated are the type of electrodes, actuation voltage and the distance in the absence of free airflow. The induced flow velocity is measured directly in the accelerated region using the particle image velocimetry technology. The results show that if corona discharge is not developed into arc discharge, the induced airflow velocity increases nearly linearly with the applied voltage and the maximum induced airflow velocity near the needle electrode reaches 36 m/s. It is expected that in the future, the result can be referred to in the research about effect of active flow control to reach much higher induced airflow speed.

  9. Triggering Excimer Lasers by Photoionization from Corona Discharges

    NASA Astrophysics Data System (ADS)

    Xiong, Zhongmin; Duffey, Thomas; Brown, Daniel; Kushner, Mark

    2009-10-01

    High repetition rate ArF (192 nm) excimer lasers are used for photolithography sources in microelectronics fabrication. In highly attaching gas mixtures, preionization is critical to obtaining stable, reproducible glow discharges. Photoionization from a separate corona discharge is one technique for preionization which triggers the subsequent electron avalanche between the main electrodes. Photoionization triggering of an ArF excimer laser sustained in multi-atmosphere Ne/Ar/F2/Xe gas mixtures has been investigated using a 2-dimensional plasma hydrodynamics model including radiation transport. Continuity equations for charged and neutral species, and Poisson's equation are solved coincident with the electron temperature with transport coefficients obtained from solutions of Boltzmann's equation. Photoionizing radiation is produced by a surface discharge which propagates along a corona-bar located adjacent to the discharge electrodes. The consequences of pulse power waveform, corona bar location, capacitance and gas mixture on uniformity, symmetry and gain of the avalanche discharge will be discussed.

  10. The biomolecular corona of nanoparticles in circulating biological media

    NASA Astrophysics Data System (ADS)

    Pozzi, D.; Caracciolo, G.; Digiacomo, L.; Colapicchioni, V.; Palchetti, S.; Capriotti, A. L.; Cavaliere, C.; Zenezini Chiozzi, R.; Puglisi, A.; Laganà, A.

    2015-08-01

    When nanoparticles come into contact with biological media, they are covered by a biomolecular `corona', which confers a new identity to the particles. In all the studies reported so far nanoparticles are incubated with isolated plasma or serum that are used as a model for protein adsorption. Anyway, bodily fluids are dynamic in nature so the question arises on whether the incubation protocol, i.e. dynamic vs. static incubation, could affect the composition and structure of the biomolecular corona. Here we let multicomponent liposomes interact with fetal bovine serum (FBS) both statically and dynamically, i.e. in contact with circulating FBS (~40 cm s-1). The structure and composition of the liposome-protein corona, as determined by dynamic light scattering, electrophoretic light scattering and liquid chromatography tandem mass spectrometry, were found to be dependent on the incubation protocol. Specifically, following dynamic exposure to FBS, multicomponent liposomes were less enriched in complement proteins and appreciably more enriched in apolipoproteins and acute phase proteins (e.g. alpha-1-antitrypsin and inter-alpha-trypsin inhibitor heavy chain H3) that are involved in relevant interactions between nanoparticles and living systems. Supported by our results, we speculate that efficient predictive modeling of nanoparticle behavior in vivo will require accurate knowledge of nanoparticle-specific protein fingerprints in circulating biological media.When nanoparticles come into contact with biological media, they are covered by a biomolecular `corona', which confers a new identity to the particles. In all the studies reported so far nanoparticles are incubated with isolated plasma or serum that are used as a model for protein adsorption. Anyway, bodily fluids are dynamic in nature so the question arises on whether the incubation protocol, i.e. dynamic vs. static incubation, could affect the composition and structure of the biomolecular corona. Here we let

  11. In Vivo Biomolecule Corona around Blood-Circulating, Clinically Used and Antibody-Targeted Lipid Bilayer Nanoscale Vesicles.

    PubMed

    Hadjidemetriou, Marilena; Al-Ahmady, Zahraa; Mazza, Mariarosa; Collins, Richard F; Dawson, Kenneth; Kostarelos, Kostas

    2015-08-25

    The adsorption of proteins and their layering onto nanoparticle surfaces has been called the "protein corona". This dynamic process of protein adsorption has been extensively studied following in vitro incubation of many different nanoparticles with plasma proteins. However, the formation of protein corona under dynamic, in vivo conditions remains largely unexplored. Extrapolation of in vitro formed protein coronas to predict the fate and possible toxicological burden from nanoparticles in vivo is of great interest. However, complete lack of such direct comparisons for clinically used nanoparticles makes the study of in vitro and in vivo formed protein coronas of great importance. Our aim was to study the in vivo protein corona formed onto intravenously injected, clinically used liposomes, based on the composition of the PEGylated liposomal formulation that constitutes the anticancer agent Doxil. The formation of in vivo protein corona was determined after the recovery of the liposomes from the blood circulation of CD-1 mice 10 min postinjection. In comparison, in vitro protein corona was formed by the incubation of liposomes in CD-1 mouse plasma. In vivo and in vitro formed protein coronas were compared in terms of morphology, composition and cellular internalization. The protein coronas on bare (non-PEGylated) and monoclonal antibody (IgG) targeted liposomes of the same lipid composition were also comparatively investigated. A network of linear fibrillary structures constituted the in vitro formed protein corona, whereas the in vivo corona had a different morphology but did not appear to coat the liposome surface entirely. Even though the total amount of protein attached on circulating liposomes correlated with that observed from in vitro incubations, the variety of molecular species in the in vivo corona were considerably wider. Both in vitro and in vivo formed protein coronas were found to significantly reduce receptor binding and cellular internalization of

  12. Temporal and Spatial Variability of the Martian Hot Oxygen Corona

    NASA Astrophysics Data System (ADS)

    Deighan, J.; Jain, S.; Chaffin, M.; Chaufray, J. Y.; Schneider, N. M.; Clarke, J. T.; Mayyasi, M.; Lillis, R. J.; Eparvier, F. G.; Thiemann, E.; Chamberlin, P. C.

    2017-12-01

    The dominant loss mechanism of oxygen from Mars to space in the current epoch is thought to be photochemical escape of hot oxygen produced by dissociative recombination of O2+. This ion is ultimately sourced from CO2+, which is the primary product of photoionization. The escaping hot oxygen population is accompanied by a gravitationally bound hot oxygen corona produced by the same mechanism. The MAVEN spacecraft has been at Mars since November 2014, with multiple seasons suitable for the IUVS instrument to observe the dayside hot oxygen corona via fluorescence of the O I 130.4 nm triplet. This provides the opportunity to examine temporal variations associated with changes in the photoionizing solar EUV radiation which produces CO2+ and O2+ ions. We present results based on two seasons: LS = 270 in Mars Year 32 during the maximum of Solar Cycle 24 and LS = 210 in Mars Year 33 late in the declining phase of the same Solar Cycle. The data in both seasons contain multiple solar rotations. We compare the oxygen corona density to the EUV solar flux measured by MAVEN/EUVM and ionization frequencies calculated therefrom. The peak brightness of ionospheric CO2+ UVD emission from IUVS limb scans is also used as a direct indicator of the photoionization frequency. As expected, the result is a strong correlation between solar EUV input, observed ionization frequency, and the density of the hot oxygen corona. In addition, a new observation strategy was employed during the MY 33 season to view the Martian corona near the sub-solar point with anti-parallel lines of sight from opposing hemispheres. These observations reveal a significant hemispherical asymmetry in brightness, providing a constraint on the large scale spatial variability of the dayside oxygen corona.

  13. APPLICATION OF CORONA DESTRUCTION AS A METHOD TO CONTROL VOLATILEORGANIC COMPOUNDS

    EPA Science Inventory

    The paper discusses EPA tests of two types of corona reactors. nemakes use of a bed of ferroelectric pellets across which analternating current electric field is impressed. he otherdevelops corona between two electrodes that have been energized bya fast rise time (nanosecond rang...

  14. Gas chemical studies using corona discharge reactors

    NASA Astrophysics Data System (ADS)

    Schulze, P.; Stankiewicz, A.; Aicher, M.; Mattner, M.; Ulrich, A.

    2010-12-01

    Corona discharges with voltages up to 60 kV (DC) were studied with the aim to induce chemical reactions in flue gases at atmospheric pressure. Various plasma reactors with different geometries of multi-needle arrays were tested. The power input was optimised by studying the electrical parameters of the set-up systematically. Both, solid and liquid electrodes were used in combination with the needle arrays. A precise positioning of the corona needles allowed operation without a ballast resistor. Formation rates for CO and the sum of NO2 and O3 are reported and discussed. Three catalytic anode-coatings were tested for their potential to decompose carbon dioxide.

  15. Solar corona during the 1994 and 1999 eclipses

    NASA Astrophysics Data System (ADS)

    Badalyan, O. G.; Sýkora, J.

    2008-06-01

    The lower and middle layers of the corona are studied analyzing the ground-based observations carried out during the November 3, 1994 and August 11, 1999 total solar eclipses. While the 1994 eclipse took place nearby the solar activity minimum, the 1999 eclipse occurred closer to the solar cycle maximum. Structures, isolines of brightness and polarization, and topology of the magnetic field lines of force (calculated under a potential approximation) of these two coronae are mutually compared. It is confirmed that the brightness distribution in the corona corresponds to the hydrostatic distribution of density at the distances 1.2-1.8R⊙. Temperature 1.4 MK and density n0 = 3.3 × 108cm-3 are found for the equatorial coronal regions of the 1999 corona. Physical conditions in the polar coronal regions are investigated analyzing the brightness and polarization of the 1994 eclipse. We have found that the degree of polarization in polar plumes is about 10% higher than that in the inter-plumes space. Consideration of the brightness in plumes and in the adjacent background space allowed us to conclude that the temperatures there are close to 1 MK. The density in the individual plumes is near n0 = 2.7 × 108cm-3, while it decreases to about n0 = 2.0 × 108cm-3 in the inter-plumes space. It is pointed out that the simultaneous interpretation of the measured brightness and polarization struggles with some difficulties.

  16. Centrally Concentrated X-Ray Radiation from an Extended Accreting Corona in Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Liu, B. F.; Taam, Ronald E.; Qiao, Erlin; Yuan, Weimin

    2017-10-01

    The X-ray emission from bright active galactic nuclei (AGNs) is believed to originate in a hot corona lying above a cold, geometrically thin accretion disk. A highly concentrated corona located within ˜10 gravitational radii above the black hole is inferred from observations. Based on the accretion of interstellar medium/wind, a disk corona model has been proposed in which the corona is well coupled to the disk by radiation, thermal conduction, as well as by mass exchange. Such a model avoids artificial energy input to the corona and has been used to interpret the spectral features observed in AGN. In this work, it is shown that the bulk emission size of the corona is very small for the extended accretion flow in our model. More than 80% of the hard X-ray power is emitted from a small region confined within 10 Schwarzschild radii around a non-spinning black hole, which is expected to be even smaller accordingly for a spinning black hole. Here, the corona emission is more extended at higher Eddington ratios. The compactness parameter of the corona, l=\\tfrac{L}{R}\\tfrac{{σ }{{T}}}{{m}{{e}}{c}3}, is shown to be in the range of 1-33 for Eddington ratios of 0.02-0.1. Combined with the electron temperature in the corona, this indicates that electron-positron pair production is not dominant in this regime. A positive relation between the compactness parameter and photon index is also predicted. By comparing the above model predictions with observational features, we find that the model is in agreement with observations.

  17. CORONA DESTRUCTION: AN INNOVATIVE CONTROL TECHNOLOGY FOR VOCS AND AIR TOXICS

    EPA Science Inventory

    This paper discusses the work and results to date leading to the demonstration of the corona destruction process at pilot scale. The research effort in corona destruction of volatile organic compounds (VOCs) and air toxics has shown significant promise for providing a valuable co...

  18. Coronae on stars

    NASA Technical Reports Server (NTRS)

    Haisch, B. M.

    1986-01-01

    Three lines of evidence are noted to point to a flare heating source for stellar coronae: a strong correlation between time-averaged flare energy release and coronal X-ray luminosity, the high temperature flare-like component of the spectral signature of coronal X-ray emission, and the observed short time scale variability that indicates continuous flare activity. It is presently suggested that flares may represent only the extreme high energy tail of a continuous distribution of coronal energy release events.

  19. Recent Studies of the Behavior of the Sun's White-Light Corona Over Time

    NASA Technical Reports Server (NTRS)

    SaintCyr, O. C.; Young, D. E.; Pesnell, W. D.; Lecinski, A.; Eddy, J.

    2008-01-01

    Predictions of upcoming solar cycles are often related to the nature and dynamics of the Sun's polar magnetic field and its influence on the corona. For the past 30 years we have a more-or-less continuous record of the Sun's white-light corona from groundbased and spacebased coronagraphs. Over that interval, the large scale features of the corona have varied in what we now consider a 'predictable' fashion--complex, showing multiple streamers at all latitudes during solar activity maximum; and a simple dipolar shape aligned with the rotational pole during solar minimum. Over the past three decades the white-light corona appears to be a better indicator of 'true' solar minimum than sunspot number since sunspots disappear for months (even years) at solar minimum. Since almost all predictions of the timing of the next solar maximum depend on the timing of solar minimum, the white-light corona is a potentially important observational discriminator for future predictors. In this contribution we describe recent work quantifying the large-scale appearance of the Sun's corona to correlate it with the sunspot record, especially around solar minimum. These three decades can be expanded with the HAO archive of eclipse photographs which, although sparse compared to the coronagraphic coverage, extends back to 1869. A more extensive understanding of this proxy would give researchers confidence in using the white-light corona as an indicator of solar minimum conditions.

  20. Diagnosing the Prominence-Cavity Connection in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Schmit, D. J.

    The energetic equilibrium of the corona is described by a balance of heating, thermal conduction, and radiative cooling. Prominences can be described by the thermal instability of coronal energy balance which leads to the formation of cool condensations. Observationally, the prominence is surrounded by a density depleted elliptical structure known as a cavity. In this dissertation, we use extreme ultraviolet remote sensing observations of the prominence-cavity system to diagnose the static and dynamic properties of these structures. The observations are compared with numerical models for the time-dependent coronal condensation process and the time-independent corona-prominence magnetic field. To diagnose the density of the cavity, we construct a three-dimensional structural model of the corona. This structural model allows us to synthesize extreme ultraviolet emission in the corona in a way that incorporates the projection effects which arise from the optically thin plasma. This forward model technique is used to constrain a radial density profile simultaneously in the cavity and the streamer. We use a χ2 minimization to find the density model which best matches a density sensitive line ratio (observed with Hinode/Extreme ultraviolet Imaging Spectrometer) and the white light scattered intensity (observed with Mauna Loa Solar Observatory MK4 coronagraph). We use extreme ultraviolet spectra and spectral images to diagnose the dynamics of the prominence and the surrounding corona. Based on the doppler shift of extreme ultraviolet coronal emission lines, we find that there are large regions of flowing plasma which appear to occur within cavities. These line of sight flows have speeds of 10 km/s-1 and projected spatial scales of 100 Mm. Using the Solar Dynamics Observatory Atmospheric Imaging Assembly (SDO/AIA) dataset, we observe dynamic emission from the prominence-cavity system. The SDO/AIA dataset observes multiple spectral bandpasses with different temperature

  1. Predicting Cell Association of Surface-Modified Nanoparticles Using Protein Corona Structure - Activity Relationships (PCSAR).

    PubMed

    Kamath, Padmaja; Fernandez, Alberto; Giralt, Francesc; Rallo, Robert

    2015-01-01

    Nanoparticles are likely to interact in real-case application scenarios with mixtures of proteins and biomolecules that will absorb onto their surface forming the so-called protein corona. Information related to the composition of the protein corona and net cell association was collected from literature for a library of surface-modified gold and silver nanoparticles. For each protein in the corona, sequence information was extracted and used to calculate physicochemical properties and statistical descriptors. Data cleaning and preprocessing techniques including statistical analysis and feature selection methods were applied to remove highly correlated, redundant and non-significant features. A weighting technique was applied to construct specific signatures that represent the corona composition for each nanoparticle. Using this basic set of protein descriptors, a new Protein Corona Structure-Activity Relationship (PCSAR) that relates net cell association with the physicochemical descriptors of the proteins that form the corona was developed and validated. The features that resulted from the feature selection were in line with already published literature, and the computational model constructed on these features had a good accuracy (R(2)LOO=0.76 and R(2)LMO(25%)=0.72) and stability, with the advantage that the fingerprints based on physicochemical descriptors were independent of the specific proteins that form the corona.

  2. Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide.

    PubMed

    Pilkington, Emily H; Gustafsson, Ove J R; Xing, Yanting; Hernandez-Fernaud, Juan; Zampronio, Cleidi; Kakinen, Aleksandr; Faridi, Ava; Ding, Feng; Wilson, Paul; Ke, Pu Chun; Davis, Thomas P

    2018-05-16

    Amyloids may be regarded as native nanomaterials that form in the presence of complex protein mixtures. By drawing an analogy with the physicochemical properties of nanoparticles in biological fluids, we hypothesized that amyloids should form a protein corona in vivo that would imbue the underlying amyloid with a modified biological identity. To explore this hypothesis, we characterized the protein corona of human islet amyloid polypeptide (IAPP) fibrils in fetal bovine serum using two complementary methodologies developed herein: quartz crystal microbalance and "centrifugal capture", coupled with nanoliquid chromatography tandem mass spectroscopy. Clear evidence for a significant protein corona was obtained. No trends were identified for amyloid corona proteins based on their physicochemical properties, whereas strong binding with IAPP fibrils occurred for linear proteins or multidomain proteins with structural plasticity. Proteomic analysis identified amyloid-enriched proteins that are known to play significant roles in mediating cellular machinery and processing, potentially leading to pathological outcomes and therapeutic targets.

  3. Rail-type gas switch with preionization by an additional corona discharge

    NASA Astrophysics Data System (ADS)

    Belozerov, O. S.; Krastelev, E. G.

    2017-05-01

    Results of an experimental research of a rail-type gas switch with preionization by an additional negative corona discharge are presented. The most of measurements were performed for an air insulated two-electrode switch assembled of cylindrical electrodes of 22 mm diameter and 100 mm length, arranged parallel to each other, with a spark gap between them varying from 6 to 15 mm. A set of 1 to 5 needles connected to a negative cylindrical electrode and located aside of them were used for corona discharges. The needle positions, allowing an effecient stabilization of the pulsed breakdown voltage and preventing the a transition of the corona discharge in a spark form, were found. It was shown that the gas preionization by the UV-radiation of the parallel corona discharge provides a stable operation of the switch with low variations of the pulsed breakdown voltage, not exceeding 1% for a given voltage rise-time tested within the range from 40 ns to 5 µs.

  4. The concept of bio-corona in modulating the toxicity of engineered nanomaterials (ENM)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Westmeier, Dana; Stauber, Roland H.; Docter, Dominic, E-mail: docter@uni-mainz.de

    Besides the wide use of engineered nanomaterials (ENM) in technical products, their application spectrum in biotechnology and biomedicine is steadily increasing. In complex physiological environments the physico-chemical properties and the behavior of nanoparticles (NPs) are challenging to characterize. Biomolecules rapidly adsorb to the nanomaterial, leading to the formation of the protein/biomolecule corona, which critically affects the nanomaterials' (patho)biological and technical identities. This formation can trigger an immune response and affect nanoparticles' toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the (protein)corona-nanoparticle interaction and discuss how the corona modulates both cytotoxicity and the immunemore » response as well as to improve the efficacy of targeted delivery of nanocarriers. - Highlights: • “Nanotoxicology” has emerged an autonomous field with an explosive growth. • Nanomaterials adsorb (bio)molecules forming the so-called (bio)molecule corona. • (Fine-)tune of the corona composition could enable new possibilities in nanomedicine.« less

  5. Probing the solar corona with very long baseline interferometry.

    PubMed

    Soja, B; Heinkelmann, R; Schuh, H

    2014-06-20

    Understanding and monitoring the solar corona and solar wind is important for many applications like telecommunications or geomagnetic studies. Coronal electron density models have been derived by various techniques over the last 45 years, principally by analysing the effect of the corona on spacecraft tracking. Here we show that recent observational data from very long baseline interferometry (VLBI), a radio technique crucial for astrophysics and geodesy, could be used to develop electron density models of the Sun's corona. The VLBI results agree well with previous models from spacecraft measurements. They also show that the simple spherical electron density model is violated by regional density variations and that on average the electron density in active regions is about three times that of low-density regions. Unlike spacecraft tracking, a VLBI campaign would be possible on a regular basis and would provide highly resolved spatial-temporal samplings over a complete solar cycle.

  6. Rayleigh-Taylor Instabilities as a Mechanism for Coronae Formation on Venus

    NASA Astrophysics Data System (ADS)

    Hoogenboom, T.; Houseman, G. A.

    2002-12-01

    Coronae are Venusian quasi-circular volcano-tectonic features that range in size from 60km-1000km. They are believed to form over small-scale mantle upwellings. Previous models of corona formation can best match the observed topographic morphology when the upwellings cause the cold, dense lower lithosphere to delaminate, sinking into the mantle and deforming the surface. These complex evolutionary models can predict the general topography of most classes of coronae and can also account for most of the deformation observed around coronae. The size and depth at which these plumes might originate is unclear, however, and the relatively close spacing of coronae is surprising if these plumes originate from deep in the mantle. We here investigate an alternative causal mechanism for coronae based on the idea that gravitational instability of the dense mantle lithosphere could also explain the observed topography and gravity. In Rayleigh-Taylor instability, coupled downwelling and upwelling develops from an initial perturbation in lithospheric thickness. Recent analysis of gravity data suggests that deformation of the crustal layer may play an important role in causing surface topography for coronae and explaining volcano-tectonic deformation features. We examine the role of crustal thickness in forming specific corona morphologies using "basil", a 2D finite deformation program adapted to calculate viscous deformation assuming cylindrical axisymmetry. Instantaneous flow fields are integrated forward in time in order to compute the final strain field. Rayleigh-Taylor instability with imposed cylindrical axisymmetry produces either central depression surrounded by a positive topographic annulus (or vice-versa). If deformation is small we observe that linear growth rates q are the same for either form of the instability. We find this rate to be maximum at wavenumber k=2.5 for rigid boundary models, but the wavelength of deformation lengthens to k=0.32 for free-slip boundaries

  7. Impact of Type II Spicules in the Corona: Simulations and Synthetic Observables

    NASA Astrophysics Data System (ADS)

    Martínez-Sykora, Juan; De Pontieu, Bart; De Moortel, Ineke; Hansteen, Viggo H.; Carlsson, Mats

    2018-06-01

    The role of type II spicules in the corona has been a much debated topic in recent years. This paper aims to shed light on the impact of type II spicules in the corona using novel 2.5D radiative MHD simulations, including ion–neutral interaction effects with the Bifrost code. We find that the formation of simulated type II spicules, driven by the release of magnetic tension, impacts the corona in various manners. Associated with the formation of spicules, the corona exhibits (1) magneto-acoustic shocks and flows, which supply mass to coronal loops, and (2) transversal magnetic waves and electric currents that propagate at Alfvén speeds. The transversal waves and electric currents, generated by the spicule’s driver and lasting for many minutes, are dissipated and heat the associated loop. These complex interactions in the corona can be connected with blueshifted secondary components in coronal spectral lines (red–blue asymmetries) observed with Hinode/EIS and SOHO/SUMER, as well as the EUV counterpart of type II spicules and propagating coronal disturbances observed with the 171 Å and 193 Å SDO/AIA channels.

  8. The "sweet" side of the protein corona: effects of glycosylation on nanoparticle-cell interactions.

    PubMed

    Wan, Sha; Kelly, Philip M; Mahon, Eugene; Stöckmann, Henning; Rudd, Pauline M; Caruso, Frank; Dawson, Kenneth A; Yan, Yan; Monopoli, Marco P

    2015-02-24

    The significance of a protein corona on nanoparticles in modulating particle properties and their biological interactions has been widely acknowledged. The protein corona is derived from proteins in biological fluids, many of which are glycosylated. To date, the glycans on the proteins have been largely overlooked in studies of nanoparticle-cell interactions. In this study, we demonstrate that glycosylation of the protein corona plays an important role in maintaining the colloidal stability of nanoparticles and influences nanoparticle-cell interactions. The removal of glycans from the protein corona enhances cell membrane adhesion and cell uptake of nanoparticles in comparison with the fully glycosylated form, resulting in the generation of a pro-inflammatory milieu by macrophages. This study highlights that the post-translational modification of proteins can significantly impact nanoparticle-cell interactions by modulating the protein corona properties.

  9. Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation.

    PubMed

    Kari, Otto K; Rojalin, Tatu; Salmaso, Stefano; Barattin, Michela; Jarva, Hanna; Meri, Seppo; Yliperttula, Marjo; Viitala, Tapani; Urtti, Arto

    2017-04-01

    When nanocarriers are administered into the blood circulation, a complex biomolecular layer known as the "protein corona" associates with their surface. Although the drivers of corona formation are not known, it is widely accepted that this layer mediates biological interactions of the nanocarrier with its surroundings. Label-free optical methods can be used to study protein corona formation without interfering with its dynamics. We demonstrate the proof-of-concept for a multi-parametric surface plasmon resonance (MP-SPR) technique in monitoring the formation of a protein corona on surface-immobilized liposomes subjected to flowing 100 % human serum. We observed the formation of formulation-dependent "hard" and "soft" coronas with distinct refractive indices, layer thicknesses, and surface mass densities. MP-SPR was also employed to determine the affinity (K D ) of a complement system molecule (C3b) with cationic liposomes with and without polyethylene glycol. Tendency to create a thick corona correlated with a higher affinity of opsonin C3b for the surface. The label-free platform provides a fast and robust preclinical tool for tuning nanocarrier surface architecture and composition to control protein corona formation.

  10. Unveiling the Molecular Structure of Pulmonary Surfactant Corona on Nanoparticles.

    PubMed

    Hu, Qinglin; Bai, Xuan; Hu, Guoqing; Zuo, Yi Y

    2017-07-25

    The growing risk of human exposure to airborne nanoparticles (NPs) causes a general concern on the biosafety of nanotechnology. Inhaled NPs can deposit in the deep lung at which they interact with the pulmonary surfactant (PS). Despite the increasing study of nano-bio interactions, detailed molecular mechanisms by which inhaled NPs interact with the natural PS system remain unclear. Using coarse-grained molecular dynamics simulation, we studied the interaction between NPs and the PS system in the alveolar fluid. It was found that regardless of different physicochemical properties, upon contacting the PS, both silver and polystyrene NPs are immediately coated with a biomolecular corona that consists of both lipids and proteins. Structure and molecular conformation of the PS corona depend on the hydrophobicity of the pristine NPs. Quantitative analysis revealed that lipid composition of the corona formed on different NPs is relatively conserved and is similar to that of the bulk phase PS. However, relative abundance of the surfactant-associated proteins, SP-A, SP-B, and SP-C, is notably affected by the hydrophobicity of the NP. The PS corona provides the NPs with a physicochemical barrier against the environment, equalizes the hydrophobicity of the pristine NPs, and may enhance biorecognition of the NPs. These modifications in physicochemical properties may play a crucial role in affecting the biological identity of the NPs and hence alter their subsequent interactions with cells and other biological entities. Our results suggest that all studies of inhalation nanotoxicology or NP-based pulmonary drug delivery should consider the influence of the PS corona.

  11. Energy distribution of nanoflares in the quiet solar corona

    NASA Astrophysics Data System (ADS)

    Ulyanov, Artyom

    2012-07-01

    We present a detailed statistical analysis of flare-like events in low layer of solar corona detected with TESIS instrument onboard CORONAS-PHOTON satellite in 171 {Å} during high-cadence (5 sec) time-series. The estimated thermal energies of these small events amount to 10^{23} - 10^{26} erg. According to modern classification flare-like events with such energies are usually referred to as nanoflares. The big number of registered events (above 2000) allowed us to obtain precise distributions of geometric and physical parameters of nanoflares, the most intriguing being energy distribution. Following Aschwanden et al. (2000) and other authors we approximated the calculated energy distribution with a single power law slope: N(E)dE ˜ N^{-α}dE. The power law index was derived to be α = 2.4 ± 0.2, which is very close to the value reported by Krucker & Benz (1998): α ≈ 2.3 - 2.4. The total energy input from registered events constitute about 10^4 erg \\cdot cm^{-2} \\cdot s^{-1}, which is well beyond net losses in quiet corona (3 \\cdot 10^5 erg \\cdot cm^{-2} \\cdot s^{-1}). However, the value of α > 2 indicates that nanoflares with lower energies dominate over nanoflares with bigger energies and could contribute considerably to quiet corona heating.

  12. Ground-based observation of emission lines from the corona of a red-dwarf star.

    PubMed

    Schmitt, J H; Wichmann, R

    2001-08-02

    All 'solar-like' stars are surrounded by coronae, which contain magnetically confined plasma at temperatures above 106 K. (Until now, only the Sun's corona could be observed in the optical-as a shimmering envelope during a total solar eclipse.) As the underlying stellar 'surfaces'-the photospheres-are much cooler, some non-radiative process must be responsible for heating the coronae. The heating mechanism is generally thought to be magnetic in origin, but is not yet understood even for the case of the Sun. Ultraviolet emission lines first led to the discovery of the enormous temperature of the Sun's corona, but thermal emission from the coronae of other stars has hitherto been detectable only from space, at X-ray wavelengths. Here we report the detection of emission from highly ionized iron (Fe XIII at 3,388.1 A) in the corona of the red-dwarf star CN Leonis, using a ground-based telescope. The X-ray flux inferred from our data is consistent with previously measured X-ray fluxes, and the non-thermal line width of 18.4 km s-1 indicates great similarities between solar and stellar coronal heating mechanisms. The accessibility and spectral resolution (45,000) of the ground-based instrument are much better than those of X-ray satellites, so a new window to the study of stellar coronae has been opened.

  13. 75 FR 8395 - Bunker Hill Groundwater Basin, Riverside-Corona Feeder Project, San Bernardino and Riverside...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Bunker Hill Groundwater Basin, Riverside-Corona...) will prepare a joint EIS/EIR for the proposed Riverside-Corona Feeder Project. The public and agencies... participate in the planning, design, and construction of the Riverside-Corona Feeder Project including: (i) 20...

  14. Corona graphs as a model of small-world networks

    NASA Astrophysics Data System (ADS)

    Lv, Qian; Yi, Yuhao; Zhang, Zhongzhi

    2015-11-01

    We introduce recursive corona graphs as a model of small-world networks. We investigate analytically the critical characteristics of the model, including order and size, degree distribution, average path length, clustering coefficient, and the number of spanning trees, as well as Kirchhoff index. Furthermore, we study the spectra for the adjacency matrix and the Laplacian matrix for the model. We obtain explicit results for all the quantities of the recursive corona graphs, which are similar to those observed in real-life networks.

  15. Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes.

    PubMed

    Aoyama, Michihiko; Hata, Katsutomo; Higashisaka, Kazuma; Nagano, Kazuya; Yoshioka, Yasuo; Tsutsumi, Yasuo

    2016-11-25

    In biological fluids, nanoparticles interact with biological components such as proteins, and a layer called the "protein corona" forms around the nanoparticles. It is believed that the composition of the protein corona affects the cellular uptake and in vivo biodistribution of nanoparticles; however, the key proteins of the protein corona that control the biological fate of nanoparticles remain unclear. Recently, it was reported that clusterin binding to pegylated nanoparticles is important for the stealth effect of pegylated nanoparticles in phagocytes. However, the effect of clusterin on non-pegylated nanoparticles is unknown, although it is known that clusterin is present in the protein corona of non-pegylated nanoparticles. Here, we assessed the stealth effect of clusterin in the corona of non-pegylated silver nanoparticles and silica nanoparticles. We found that serum- and plasma-protein corona inhibited the cellular uptake of silver nanoparticles and silica nanoparticles in phagocytes and that the plasma-protein corona showed a greater stealth effect compared with the serum-protein corona. Clusterin was present in both the serum- and plasma-protein corona, but was present at a higher level in the plasma-protein corona than in the serum-protein corona. Clusterin binding to silver nanoparticles and silica nanoparticles suppressed the cellular uptake of nanoparticles in human macrophage-like cells (THP-1 cells). Although further studies are required to determine how clusterin suppresses non-specific cellular uptake in phagocytes, our data suggest that clusterin plays a key role in the stealth effect of not only pegylated nanoparticles but also non-pegylated nanoparticles. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Modeling of power transmission and stress grading for corona protection

    NASA Astrophysics Data System (ADS)

    Zohdi, T. I.; Abali, B. E.

    2017-11-01

    Electrical high voltage (HV) machines are prone to corona discharges leading to power losses as well as damage of the insulating layer. Many different techniques are applied as corona protection and computational methods aid to select the best design. In this paper we develop a reduced-order model in 1D estimating electric field and temperature distribution of a conductor wrapped with different layers, as usual for HV-machines. Many assumptions and simplifications are undertaken for this 1D model, therefore, we compare its results to a direct numerical simulation in 3D quantitatively. Both models are transient and nonlinear, giving a possibility to quickly estimate in 1D or fully compute in 3D by a computational cost. Such tools enable understanding, evaluation, and optimization of corona shielding systems for multilayered coils.

  17. Close-up View of Atete Corona

    NASA Image and Video Library

    1998-06-03

    This view from NASA's Magellan spacecraft is a close-up of Atete Corona, a 600-km-long and 450-km-wide feature at latitude 16 degrees S., longitude 244 degrees; looking north. http://photojournal.jpl.nasa.gov/catalog/PIA00097

  18. LABORATORY ANALYSIS OF BACK-CORONA DISCHARGE

    EPA Science Inventory

    The paper discusses an experimental research program to characterize back-corona generation and behavior in a range of environments and geometries common to electrostatic precipitators (ESPs). A wire-parallel plate device was used to monitor the intensity and distribution of back...

  19. Development of a positive corona from a long grounded wire in a growing thunderstorm field

    NASA Astrophysics Data System (ADS)

    Mokrov, M. S.; Raizer, Yu P.; Bazelyan, E. M.

    2013-11-01

    The properties of a non-stationary corona initiated from a long grounded wire suspended horizontally above the ground and coronating in a slowly varying thundercloud electric field are studied. A two-dimensional (2D) model of the corona is developed. On the basis of this model, characteristics of the corona produced by a lightning protection wire are calculated under thunderstorm conditions. The corona characteristics are also found by using approximate analytical and quasi-one-dimensional numerical models. The results of these models agree reasonably well with those obtained from the 2D simulation. This allows one to estimate the corona parameters without recourse to the cumbersome simulation. This work was performed with a view to study the efficiency of lightning protection wires later on.

  20. Possible giant metamorphic core complex at the center of Artemis Corona, Venus

    USGS Publications Warehouse

    Spencer, J.E.

    2001-01-01

    Hundreds of circular features on Venus known as coronae are characterized by annular fractures and commonly associated radial fractures and lava flows. Coronae are thought to have been produced by buoyant mantle diapirs that flatten and spread at the base of the lithosphere and cause fracturing, uplift, and magmatism. The interior of Artemis Corona, by far the largest corona at 2100 km diameter, is divided in half by a northeast-trending deformation belt that contains numerous rounded ridges resembling antiforms. The largest of these ridges, located at the center of Artemis Corona, is ???5 km high on its steep northwest flank where it is adjacent to a flat-bottomed, 10-km-wide trough interpreted as a rift valley. The 280-km-long antiformal ridge is marked by perpendicular grooves that cross the ???50-km-wide ridge and extend southeastward as far as 120 km across adjacent plains. The grooves abruptly terminate northwestward at the rift trough. The large antiformal ridge terminates southwestward at a transform shear zone that parallels the grooves. These features-rift valley, antiformal uplift, grooves, and transform shear zone-are morphologically and geometrically similar to grooved, elevated, submarine metamorphic core complexes on the inside corners of ridge-transform intersections of slow-spreading ridges on Earth. As with submarine core complexes, the grooved surface on Venus is interpreted as the footwall of a large-displacement normal fault, and the grooves are inferred to be the product of plastic molding of the footwall to irregularities on the underside of the hanging wall followed by tectonic exhumation of the molded grooves and conveyer-belt-like transport up and over the large antiform and across the southeastern plains. According to this interpretation, the trend of the grooves records the direction of extension, which is perpendicular to the thrusts at the leading edge of the annular thrust belt 1000 km to the southeast. Both may have formed at the

  1. The Structure and Dynamics of the Corona - Heliosphere Connection

    NASA Technical Reports Server (NTRS)

    Antiochos, Spiro K.; Linker, Jon A.; Lionello, Roberto; Mikic, Zoran; Titov, Viacheslav; Zurbuchen, Thomas H.

    2011-01-01

    Determining the source at the Sun of the slow solar wind is one of the major unsolved problems in solar and heliospheric physics. First, we review the existing theories for the slow wind and argue that they have difficulty accounting for both the observed composition of the wind and its large angular extent. A new theory in which the slow wind originates from the continuous opening and closing of narrow open field corridors, the S-Web model, is described. Support for the S-Web model is derived from MHD solutions for the quasisteady corona and wind during the time of the August 1, 2008 eclipse. Additionally, we perform fully dynamic numerical simulations of the corona and heliosphere in order to test the S-Web model as well as the interchange model proposed by Fisk and co-workers. We discuss the implications of our simulations for the competing theories and for understanding the corona - heliosphere connection, in general.

  2. The Structure and Dynamics of the Corona - Heliosphere Connection

    NASA Technical Reports Server (NTRS)

    Antiochos, Spiro K.; Linker, Jon A.; Lionello, Roberto; Mikic, Zoran; Titov, Viacheslav; Zurbuchen, Thomas H.

    2010-01-01

    Determining the source at the Sun of the slow solar wind is one of the major unsolved problems in solar and heliospheric physics. First, we review the existing theories for the slow wind and argue that they have difficulty accounting for both the observed composition of the wind and its large angular extent. A new theory in which the slow wind originates from the continuous opening and closing of narrow open field corridors, the S-Web model, is described. Support for the S-Web model is derived from MHD solutions for the quasisteady corona and wind during the time of the August 1, 2008 eclipse. Additionally, we perform fully dynamic numerical simulations of the corona and heliosphere in order to test the S-Web model as well as the interchange model proposed by Fisk and co-workers. We discuss the implications of our simulations for the competing theories and for understanding the corona - heliosphere connection, in general.

  3. Driving extreme variability: the evolving corona and evidence for jet launching in Markarian 335

    NASA Astrophysics Data System (ADS)

    Wilkins, D. R.; Gallo, L. C.

    2015-05-01

    Variations in the X-ray emission from the narrow-line Seyfert 1 galaxy, Markarian 335, are studied on both long and short time-scales through observations made between 2006 and 2013 with XMM-Newton, Suzaku and NuSTAR. Changes in the geometry and energetics of the corona that give rise to this variability are inferred through measurements of the relativistically blurred reflection seen from the accretion disc. On long time-scales, we find that during the high-flux epochs the corona has expanded, covering the inner regions of the accretion disc out to a radius of 26_{-7}^{+10} rg. The corona contracts to within 12rg and 5rg in the intermediate- and low-flux epochs, respectively. While the earlier high-flux observation made in 2006 is consistent with a corona extending over the inner part of the accretion disc, a later high-flux observation that year revealed that the X-ray source had become collimated into a vertically extended jet-like corona and suggested relativistic motion of material upwards. On short time-scales, we find that an X-ray flare during a low-flux epoch in 2013 corresponded to a reconfiguration from a slightly extended corona to one much more compact, within just 2 ˜ 3rg of the black hole. There is evidence that during the flare itself, the spectrum softened and the corona became collimated and slightly extended vertically as if a jet-launching event was aborted. Understanding the evolution of the X-ray emitting corona may reveal the underlying mechanism by which the luminous X-ray sources in AGN are powered.

  4. The detailed characteristics of positive corona current pulses in the line-to-plane electrodes

    NASA Astrophysics Data System (ADS)

    Xuebao, LI; Dayong, LI; Qian, ZHANG; Yinfei, LI; Xiang, CUI; Tiebing, LU

    2018-05-01

    The corona current pulses generated by corona discharge are the sources of the radio interference from transmission lines and the detailed characteristics of the corona current pulses from conductor should be investigated in order to reveal their generation mechanism. In this paper, the line-to-plane electrodes are designed to measure and analyze the characteristics of corona current pulses from positive corona discharges. The influences of inter-electrode gap and line diameters on the detail characteristics of corona current pulses, such as pulse amplitude, rise time, duration time and repetition frequency, are carefully analyzed. The obtained results show that the pulse amplitude and the repetition frequency increase with the diameter of line electrode when the electric fields on the surface of line electrodes are same. With the increase of inter-electrode gap, the pulse amplitude and the repetition frequency first decrease and then turn to be stable, while the rise time first increases and finally turns to be stable. The distributions of electric field and space charges under the line electrodes are calculated, and the influences of inter-electrode gap and line electrode diameter on the experimental results are qualitatively explained.

  5. The Structure of Titan’s N2 and CH4 Coronae

    NASA Astrophysics Data System (ADS)

    Jiang, Fayu; Cui, Jun; Xu, Jiyao

    2017-12-01

    In this study, we analyze the structures of Titan’s N2 and CH4 coronae using a large data set acquired by the Ion Neutral Mass Spectrometer (INMS) instrument on board Cassini. The N2 and CH4 densities measured from the exobase up to 2000 km imply a mean exobase temperature of 146 K and 143 K, respectively, which is lower than the mean upper atmospheric temperature by 4 and 7 K. This indicates that on average, Titan possesses a subthermal rather than suprathermal corona. A careful examination reveals that the variability in corona structure is not very likely to be solar driven. Within the framework of the collisionless kinetic model, we investigate how the CH4 energy distribution near the exobase could be constrained if strong CH4 escape occurs on Titan. Several functional forms for the CH4 energy distribution are attempted, assuming two representative CH4 escape rates of 1.2× {10}25 s-1 and 2.2× {10}27 s-1. We find that the double Maxwellian and power-law distributions can reproduce the shape of the CH4 corona structure as well as the imposed CH4 escape rate. In both cases, the escape rate is contributed by a suprathermal CH4 population on the high-energy tail, with a number fraction below 5% and a characteristic energy of 0.1-0.6 eV per suprathermal CH4 molecule. The coexistence of the subthermal CH4 corona revealed by the INMS data and substantial CH4 escape suggested by some previous works could be reconciled by a significant departure in the exobase CH4 energy distribution from ideal Maxwellian that enhances escape and causes a noticeable redistribution of the corona structure.

  6. A magnetic-dependent protein corona of tailor-made superparamagnetic iron oxides alters their biological behaviors

    NASA Astrophysics Data System (ADS)

    Liu, Ziyao; Zhan, Xiaohui; Yang, Minggang; Yang, Qi; Xu, Xianghui; Lan, Fang; Wu, Yao; Gu, Zhongwei

    2016-03-01

    In recent years, it is becoming increasingly evident that once nanoparticles come into contact with biological fluids, a protein corona surely forms and critically affects the biological behaviors of nanoparticles. Herein, we investigate whether the formation of protein corona on the surface of superparamagnetic iron oxides (SPIOs) is influenced by static magnetic field. Under static magnetic field, there is no obvious variation in the total amount of protein adsorption, but the proportion of adsorbed proteins significantly changes. Noticeably, certain proteins including apolipoproteins, complement system proteins and acute phase proteins, increase in the protein corona of SPIOs in the magnetic field. More importantly, the magnetic-dependent protein corona of SPIOs enhances the cellular uptake of SPIOs into the normal cell line (3T3 cells) and tumor cell line (HepG2 cells), due to increased adsorption of apolipoprotein. In addition, SPIOs with the magnetic-dependent protein corona cause high cytotoxicity to 3T3 cells and HepG2 cells. This work discloses that superparamagnetism as a key feature of SPIOs affects the composition of protein corona to a large extent, which further alters the biological behaviors of SPIOs.In recent years, it is becoming increasingly evident that once nanoparticles come into contact with biological fluids, a protein corona surely forms and critically affects the biological behaviors of nanoparticles. Herein, we investigate whether the formation of protein corona on the surface of superparamagnetic iron oxides (SPIOs) is influenced by static magnetic field. Under static magnetic field, there is no obvious variation in the total amount of protein adsorption, but the proportion of adsorbed proteins significantly changes. Noticeably, certain proteins including apolipoproteins, complement system proteins and acute phase proteins, increase in the protein corona of SPIOs in the magnetic field. More importantly, the magnetic-dependent protein

  7. Effect of the Protein Corona on Antibody-Antigen Binding in Nanoparticle Sandwich Immunoassays.

    PubMed

    de Puig, Helena; Bosch, Irene; Carré-Camps, Marc; Hamad-Schifferli, Kimberly

    2017-01-18

    We investigated the effect of the protein corona on the function of nanoparticle (NP) antibody (Ab) conjugates in dipstick sandwich immunoassays. Ab specific for Zika virus nonstructural protein 1 (NS1) were conjugated to gold NPs, and another anti-NS1 Ab was immobilized onto the nitrocellulose membrane. Sandwich immunoassay formation was influenced by whether the strip was run in corona forming conditions, i.e., in human serum. Strips run in buffer or pure solutions of bovine serum albumin exhibited false positives, but those run in human serum did not. Serum pretreatment of the nitrocellulose also eliminated false positives. Corona formation around the NP-Ab in serum was faster than the immunoassay time scale. Langmuir binding analysis determined how the immobilized Ab affinity for the NP-Ab/NS1 was impacted by corona formation conditions, quantified as an effective dissociation constant, K D eff . Results show that corona formation mediates the specificity and sensitivity of the antibody-antigen interaction of Zika biomarkers in immunoassays, and plays a critical but beneficial role.

  8. Research on the correlation between corona current spectrum and audible noise spectrum of HVDC transmission line

    NASA Astrophysics Data System (ADS)

    Liu, Yingyi; Zhou, Lijuan; Liu, Yuanqing; Yuan, Haiwen; Ji, Liang

    2017-11-01

    Audible noise is closely related to corona current on a high voltage direct current (HVDC) transmission line. In this paper, we measured a large amount of audible noise and corona current waveforms simultaneously based on the largest outdoor HVDC corona cage all over the world. By analyzing the experimental data, the related statistical regularities between a corona current spectrum and an audible noise spectrum were obtained. Furthermore, the generation mechanism of audible noise was analyzed theoretically, and the related mathematical expression between the audible noise spectrum and the corona current spectrum, which is suitable for all of these measuring points in the space, has been established based on the electro-acoustic conversion theory. Finally, combined with the obtained mathematical relation, the internal reasons for these statistical regularities appearing in measured corona current and audible noise data were explained. The results of this paper not only present the statistical association regularities between the corona current spectrum and the audible noise spectrum on a HVDC transmission line, but also reveal the inherent reasons of these associated rules.

  9. Heart failure disease management programs: a cost-effectiveness analysis.

    PubMed

    Chan, David C; Heidenreich, Paul A; Weinstein, Milton C; Fonarow, Gregg C

    2008-02-01

    Heart failure (HF) disease management programs have shown impressive reductions in hospitalizations and mortality, but in studies limited to short time frames and high-risk patient populations. Current guidelines thus only recommend disease management targeted to high-risk patients with HF. This study applied a new technique to infer the degree to which clinical trials have targeted patients by risk based on observed rates of hospitalization and death. A Markov model was used to assess the incremental life expectancy and cost of providing disease management for high-risk to low-risk patients. Sensitivity analyses of various long-term scenarios and of reduced effectiveness in low-risk patients were also considered. The incremental cost-effectiveness ratio of extending coverage to all patients was $9700 per life-year gained in the base case. In aggregate, universal coverage almost quadrupled life-years saved as compared to coverage of only the highest quintile of risk. A worst case analysis with simultaneous conservative assumptions yielded an incremental cost-effectiveness ratio of $110,000 per life-year gained. In a probabilistic sensitivity analysis, 99.74% of possible incremental cost-effectiveness ratios were <$50,000 per life-year gained. Heart failure disease management programs are likely cost-effective in the long-term along the whole spectrum of patient risk. Health gains could be extended by enrolling a broader group of patients with HF in disease management.

  10. Reticulated Vitreous Carbon Electrodes for Gas Phase Pulsed Corona Reactors.

    DTIC Science & Technology

    1999-01-01

    AFRL-ML-TY-TP-1999-4546 RETICULATED VITREOUS CARBON ELECTRODES FOR GAS PHASE PULSED CORONA REACTORS B.R. LOCKE M. KIRKPATRICK H. HANSON W.C...SUBTITLE Reticulated Vitreous Carbon Electrodes for Gas Phase Pulsed Corona Reactors 6. AUTHOR(S) B.R. Locke, M. Kirkpatrick, H. Hanson, and W.C. Finney...incorporating reticulated vitreous carbon electrodes is demonstrated to be effective for the removal of nitrogen oxides from synthetic air mixtures

  11. The function of the floral corona in the pollination of a Mediterranean style dimorphic daffodil.

    PubMed

    Pérez-Barrales, R; Abarca, C A; Santos-Gally, R; Schiestl, F P; Arroyo, J

    2018-01-01

    Narcissus papyraceus is a style dimorphic species with two floral forms, with anthers at similar height and stigmas above (long-styled L) and below (short-styled S) the anther level. The species is self-incompatible, but intra- and inter-morph compatible. Populations are either dimorphic (including both morphs) in the region of the Strait of Gibraltar, or L-monomorphic (with only L plants) in the inland of the Iberian Peninsula. This variation correlates with the most common floral visitors, being primarily long-tongued and short-tongued pollinators, respectively, a rare condition in Mediterranean plants. The maintenance of S-flowers relies on long-tongued insects, as only those deliver pollen to short-styled stigmas. Narcissus flowers present a long and narrow tube, at the bottom of which nectar accumulates, and a floral corona, which has been proposed as an important trait for the attraction of pollinators. Here we tested the importance of the corona on pollination of L and S flowers. We described UV reflectance patterns of the corona and tepals, and characterised VOCs in intact flowers and flowers with trimmed coronas. We also conducted a field experiment in the dimorphic and monomorphic region to estimate the importance of corona removal on seed production in stands with solitary plants and in groups to control for compatible pollen limitation. Reflectance was higher in the tepals than the corona, although both traits presented a reflectance peak around 450 nm wavelength. L- and S-flowers produced similar volatiles, regardless of the manipulation of the corona. Across dimorphic and monomorphic regions, S-flowers with the corona removed suffered a reduction in seed production of ca. 50%, while seed production remained similar in L flowers both with the corona intact and removed. Plants in solitary stands suffered a strong reduction in seed production, which was more pronounced in the monomorphic region. Our results suggest that the corona in Narcissus is more

  12. Axial diffusivity of the corona radiata correlated with ventricular size in adult hydrocephalus.

    PubMed

    Cauley, Keith A; Cataltepe, Oguz

    2014-07-01

    Hydrocephalus causes changes in the diffusion-tensor properties of periventricular white matter. Understanding the nature of these changes may aid in the diagnosis and treatment planning of this relatively common neurologic condition. Because ventricular size is a common measure of the severity of hydrocephalus, we hypothesized that a quantitative correlation could be made between the ventricular size and diffusion-tensor changes in the periventricular corona radiata. In this article, we investigated this relationship in adult patients with hydrocephalus and in healthy adult subjects. Diffusion-tensor imaging metrics of the corona radiata were correlated with ventricular size in 14 adult patients with acute hydrocephalus, 16 patients with long-standing hydrocephalus, and 48 consecutive healthy adult subjects. Regression analysis was performed to investigate the relationship between ventricular size and the diffusion-tensor metrics of the corona radiata. Subject age was analyzed as a covariable. There is a linear correlation between fractional anisotropy of the corona radiata and ventricular size in acute hydrocephalus (r = 0.784, p < 0.001), with positive correlation with axial diffusivity (r = 0.636, p = 0.014) and negative correlation with radial diffusivity (r = 0.668, p = 0.009). In healthy subjects, axial diffusion in the periventricular corona radiata is more strongly correlated with ventricular size than with patient age (r = 0.466, p < 0.001, compared with r = 0.058, p = 0.269). Axial diffusivity of the corona radiata is linearly correlated with ventricular size in healthy adults and in patients with hydrocephalus. Radial diffusivity of the corona radiata decreases linearly with ventricular size in acute hydrocephalus but is not significantly correlated with ventricular size in healthy subjects or in patients with long-standing hydrocephalus.

  13. Impact crater densities on volcanoes and coronae on venus: implications for volcanic resurfacing.

    PubMed

    Namiki, N; Solomon, S C

    1994-08-12

    The density of impact craters on large volcanoes on Venus is half the average crater density for the planet. The crater density on some classes of coronae is not significantly different from the global average density, but coronae with extensive associated volcanic deposits have lower crater densities. These results are inconsistent with both single-age and steady-state models for global resurfacing and suggest that volcanoes and coronae with associated volcanism have been active on Venus over the last 500 million years.

  14. INDUCED SCATTERING LIMITS ON FAST RADIO BURSTS FROM STELLAR CORONAE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lyubarsky, Yuri; Ostrovska, Sofiya

    2016-02-10

    The origin of fast radio bursts remains a puzzle. Suggestions have been made that they are produced within the Earth’s atmosphere, in stellar coronae, in other galaxies, or at cosmological distances. If they are extraterrestrial, the implied brightness temperature is very high, and therefore the induced scattering places constraints on possible models. In this paper, constraints are obtained on flares from coronae of nearby stars. It is shown that the radio pulses with the observed power could not be generated if the plasma density within and in the nearest vicinity of the source is as high as is necessary tomore » provide the observed dispersion measure. However, one cannot exclude the possibility that the pulses are generated within a bubble with a very low density and pass through the dense plasma only in the outer corona.« less

  15. Silver nanoparticle-human hemoglobin interface: time evolution of the corona formation and interaction phenomenon

    NASA Astrophysics Data System (ADS)

    Bhunia, A. K.; Kamilya, T.; Saha, S.

    2017-10-01

    In this paper, we have used spectroscopic and electron microscopic analysis to monitor the time evolution of the silver nanoparticles (Ag NP)-human hemoglobin (Hb) corona formation and to characterize the interaction of the Ag NPs with Hb. The time constants for surface plasmon resonance binding and reorganization are found to be 9.51 and 118.48 min, respectively. The drop of surface charge and the increase of the hydrodynamic diameter indicated the corona of Hb on the Ag NP surface. The auto correlation function is found to broaden with the increasing time of the corona formation. Surface zeta potential revealed that positively charged Hb interact electrostatically with negatively charged Ag NP surfaces. The change in α helix and β sheet depends on the corona formation time. The visualization of the Hb corona from HRTEM showed large number of Hb domains aggregate containing essentially Ag NPs and without Ag NPs. Emission study showed the tertiary deformation, energy transfer, nature of interaction and quenching under three different temperatures.

  16. Influence of Relative Humidity on AC Corona Discharge from Algae Attached on the Silicone Rubber

    NASA Astrophysics Data System (ADS)

    Sato, Daisuke; Hara, Yoshiaki; Kokufu, Morihide; Higashiyama, Yoshio

    To make clear the influence of algae growth at the surface of a polymer insulator in a practical transmission line, the characteristics of ac corona discharge from an aggregate algae particle were investigated. The aggregate algae particle was made of Protococcus viridis. Corona onset voltage from an aggregate algae particle was decreased as relative humidity increased. Under the condition of relatively higher relative humidity, luminous channel of corona discharge became more strongly and the number of corona pulses in the current waveform was increased. For an aggregate algae particle contaminated with sea salt including MgCl2, corona onset voltage decreased drastically at relative humidity above 40%. This property would result from deliquescence of MgCl2. Corona discharge was strongly affected by existence of MgCl2 in an aggregate algae particle. Surface resistance of algae attached to the surface of the silicone rubber sheet decreased in fourth figures for relative humidity from 20 to 90%. Therefore, the existence of algae on the polymer insulator inevitably affects the electric property and the surface property of the polymer insulator.

  17. A theory of heating of quiet solar corona

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, C. S., E-mail: cszcwu@msn.com; Institute of Space Science, National Central University, Zhongli 32001, Taiwan; Insitute for Physical Sciences and Technology, University of Maryland, College Park, Maryland 20742

    A theory is proposed to discuss the creation of hot solar corona. We pay special attention to the transition region and the low corona, and consider that the sun is quiet. The proposed scenario suggests that the protons are heated by intrinsic Alfvénic turbulence, while the ambient electrons are heated by the hot protons via collisions. The theory contains two prime components: the generation of the Alfvénic fluctuations by the heavy minor ions in the transition region and second, the explanation of the temperature profile in the low solar atmosphere. The proposed heating process operates continuously in time and globallymore » in space.« less

  18. The Substructure of the Solar Corona Observed in the Hi-C Telescope

    NASA Technical Reports Server (NTRS)

    Winebarger, A.; Cirtain, J.; Golub, L.; DeLuca, E.; Savage, S.; Alexander, C.; Schuler, T.

    2014-01-01

    In the summer of 2012, the High-resolution Coronal Imager (Hi-C) flew aboard a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore calculate how the intensity scales from a low-resolution (AIA) pixels to high-resolution (Hi-C) pixels for both the dynamic events and "background" emission (meaning, the steady emission over the 5 minutes of data acquisition time). We find there is no evidence of substructure in the background corona; the intensity scales smoothly from low-resolution to high-resolution Hi-C pixels. In transient events, however, the intensity observed with Hi-C is, on average, 2.6 times larger than observed with AIA. This increase in intensity suggests that AIA is not resolving these events. This result suggests a finely structured dynamic corona embedded in a smoothly varying background.

  19. R Coronae Australis: A Cosmic Watercolour

    NASA Astrophysics Data System (ADS)

    2010-06-01

    This magnificent view of the region around the star R Coronae Australis was created from images taken with the Wide Field Imager (WFI) at ESO's La Silla Observatory in Chile. R Coronae Australis lies at the heart of a nearby star-forming region and is surrounded by a delicate bluish reflection nebula embedded in a huge dust cloud. The image reveals surprising new details in this dramatic area of sky. The star R Coronae Australis lies in one of the nearest and most spectacular star-forming regions. This portrait was taken by the Wide Field Imager (WFI) on the MPG/ESO 2.2-metre telescope at the La Silla Observatory in Chile. The image is a combination of twelve separate pictures taken through red, green and blue filters. This image shows a section of sky that spans roughly the width of the full Moon. This is equivalent to about four light-years at the distance of the nebula, which is located some 420 light-years away in the small constellation of Corona Australis (the Southern Crown). The complex is named after the star R Coronae Australis, which lies at the centre of the image. It is one of several stars in this region that belong to the class of very young stars that vary in brightness and are still surrounded by the clouds of gas and dust from which they formed. The intense radiation given off by these hot young stars interacts with the gas surrounding them and is either reflected or re-emitted at a different wavelength. These complex processes, determined by the physics of the interstellar medium and the properties of the stars, are responsible for the magnificent colours of nebulae. The light blue nebulosity seen in this picture is mostly due to the reflection of starlight off small dust particles. The young stars in the R Coronae Australis complex are similar in mass to the Sun and do not emit enough ultraviolet light to ionise a substantial fraction of the surrounding hydrogen. This means that the cloud does not glow with the characteristic red colour seen in

  20. Flexural models of trench/outer rise topography of coronae on Venus with axisymmetric spherical shell elastic plates

    NASA Technical Reports Server (NTRS)

    Moore, W.; Schubert, Gerald; Sandwell, David T.

    1992-01-01

    Magellan altimetry has revealed that many coronae on Venus have trenches or moats around their peripheries and rises outboard of the trenches. This trench/outer rise topographic signature is generally associated with the tectonic annulus of the corona. Sandwell and Schubert have interpreted the trench/outer rise topography and the associated tectonic annulus around coronae to be the result of elastic bending of the Venus lithosphere (though the tectonic structures are consequences of inelastic deformation of the lithosphere). They used two-dimensional elastic plate flexure theory to fit topographic profiles across a number of large coronae and inferred elastic lithosphere thicknesses between about 15 and 40 km, similar to inferred values of elastic thickness for the Earth's lithosphere at subduction zones around the Pacific Ocean. Here, we report the results of using axisymmetric elastic flexure theory for the deformation of thin spherical shell plates to interpret the trench/outer rise topography of the large coronae modeled by Sandwell and Schubert and of coronae as small as 250 km in diameter. In the case of a corona only a few hundred kilometers in diameter, the model accounts for the small planform radius of the moat and the nonradial orientation of altimetric traces across the corona. By fitting the flexural topography of coronae we determine the elastic thickness and loading necessary to account for the observed flexure. We calculate the associated bending moment and determine whether the corona interior topographic load can provide the required moment. We also calculate surface stresses and compare the stress distribution with the location of annular tectonic features.

  1. LOFAR observations of the quiet solar corona

    NASA Astrophysics Data System (ADS)

    Vocks, C.; Mann, G.; Breitling, F.; Bisi, M. M.; Dąbrowski, B.; Fallows, R.; Gallagher, P. T.; Krankowski, A.; Magdalenić, J.; Marqué, C.; Morosan, D.; Rucker, H.

    2018-06-01

    Context. The quiet solar corona emits meter-wave thermal bremsstrahlung. Coronal radio emission can only propagate above that radius, Rω, where the local plasma frequency equals the observing frequency. The radio interferometer LOw Frequency ARray (LOFAR) observes in its low band (10-90 MHz) solar radio emission originating from the middle and upper corona. Aims: We present the first solar aperture synthesis imaging observations in the low band of LOFAR in 12 frequencies each separated by 5 MHz. From each of these radio maps we infer Rω, and a scale height temperature, T. These results can be combined into coronal density and temperature profiles. Methods: We derived radial intensity profiles from the radio images. We focus on polar directions with simpler, radial magnetic field structure. Intensity profiles were modeled by ray-tracing simulations, following wave paths through the refractive solar corona, and including free-free emission and absorption. We fitted model profiles to observations with Rω and T as fitting parameters. Results: In the low corona, Rω < 1.5 solar radii, we find high scale height temperatures up to 2.2 × 106 K, much more than the brightness temperatures usually found there. But if all Rω values are combined into a density profile, this profile can be fitted by a hydrostatic model with the same temperature, thereby confirming this with two independent methods. The density profile deviates from the hydrostatic model above 1.5 solar radii, indicating the transition into the solar wind. Conclusions: These results demonstrate what information can be gleaned from solar low-frequency radio images. The scale height temperatures we find are not only higher than brightness temperatures, but also than temperatures derived from coronograph or extreme ultraviolet (EUV) data. Future observations will provide continuous frequency coverage. This continuous coverage eliminates the need for local hydrostatic density models in the data analysis and

  2. The Soft X-Ray/Microwave Ratio of Solar and Stellar Flares and Coronae

    NASA Technical Reports Server (NTRS)

    Benz, A. O.; Guedel, M.

    1994-01-01

    We have carried out plasma diagnostics of solar flares using soft X-ray (SXR) and simultaneous microwave observations and have compared the ratio of X-ray to microwave luminosities of solar flares with various active late-type stars available in the published literature. Both the SXR low-level ('quiescent') emission from stellar coronae and the flaring emission from the Sun and stars are generally interpreted as thermal radiations of coronal plasmas. On the other hand, the microwave emission of stars and solar flares is generally attributed to an extremely hot or nonthermal population of electrons. Solar flare SXR are conventionally measured in a narrower and harder passband than the stellar sources. Observations of the GOES-2 satellite in two energy channels have been used to estimate the luminosity of solar flares as it would appear in the ROSAT satellite passband. The solar and stellar flare luminosities fit well at the lower end of the active stellar coronae. The flare SXR/microwave ratio is similar to the ratio for stellar coronae. The average ratio follows a power-law relation L(sub X) varies as L(sub R)(sup 0.73 +/- 0.03) over 10 orders of magnitude from solar microflares to RS CVn and FK Com-type coronae. Dwarf Me and Ke stars, and RS CVn stars are also compatible with a linear SXR/microwave relation, but the ratio is slightly different for each type of star. Considering the differences between solar flares, stellar flares and the various active stellar coronae, the similarity of the SXR/microwave ratios is surprising. It suggests that the energetic electrons in low-level stellar coronae observed in microwaves are related in a similar way to the coronal thermal plasma as flare electrons to the flare thermal plasma, and, consequently, that the heating mechanism of active stellar coronae is a flare-like process.

  3. A semi-analytical study of positive corona discharge in wire-plane electrode configuration

    NASA Astrophysics Data System (ADS)

    Yanallah, K.; Pontiga, F.; Chen, J. H.

    2013-08-01

    Wire-to-plane positive corona discharge in air has been studied using an analytical model of two species (electrons and positive ions). The spatial distributions of electric field and charged species are obtained by integrating Gauss's law and the continuity equations of species along the Laplacian field lines. The experimental values of corona current intensity and applied voltage, together with Warburg's law, have been used to formulate the boundary condition for the electron density on the corona wire. To test the accuracy of the model, the approximate electric field distribution has been compared with the exact numerical solution obtained from a finite element analysis. A parametrical study of wire-to-plane corona discharge has then been undertaken using the approximate semi-analytical solutions. Thus, the spatial distributions of electric field and charged particles have been computed for different values of the gas pressure, wire radius and electrode separation. Also, the two dimensional distribution of ozone density has been obtained using a simplified plasma chemistry model. The approximate semi-analytical solutions can be evaluated in a negligible computational time, yet provide precise estimates of corona discharge variables.

  4. Self-sustained criterion with photoionization for positive dc corona plasmas between coaxial cylinders

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zheng, Yuesheng, E-mail: yueshengzheng@fzu.edu.cn; Zhang, Bo, E-mail: shizbcn@tsinghua.edu.cn; He, Jinliang, E-mail: hejl@tsinghua.edu.cn

    The positive dc corona plasmas between coaxial cylinders in air under the application of a self-sustained criterion with photoionization are investigated in this paper. A photon absorption function suitable for cylindrical electrode, which can characterize the total photons within the ionization region, is proposed on the basis of the classic corona onset criteria. Based on the general fluid model with the self-sustained criterion, the role of photoionization in the ionization region is clarified. It is found that the surface electric field keeps constant under a relatively low corona current, while it is slightly weakened with the increase of the coronamore » current. Similar tendencies can be found under different conductor radii and relative air densities. The small change of the surface electric field will become more significant for the electron density distribution as well as the ionization activity under a high corona current, compared with the results under the assumption of a constant surface field. The assumption that the surface electric field remains constant should be corrected with the increase of the corona current when the energetic electrons with a distance from the conductor surface are concerned.« less

  5. [Research on electron density in DC needle-plate corona discharge at atmospheric pressure].

    PubMed

    Liu, Zhi-Qiang; Guo, Wei; Liu, Tao-Tao; Wu, Wen-Shuo; Liu, Shu-Min

    2013-11-01

    Using needle-plate discharge device, corona discharge experiment was done in the atmosphere. Through photo of spot size of light-emitting area, the relationship between the voltage and thickness of corona layer was discussed. When the distance between tip and plate is fixed, the thickness of corona layer increases with the increase in voltage; when the voltage is fixed, the thickness of corona layer decreases with the increase in the distance between tip and plate. As spectral intensity of N2 (C3pi(u)) (337.1 nm)reflects high energy electron density, it was measured with emission spectrometry. The results show that high energy electron density is the biggest near the needle tip and the relationship between high energy electron density and voltage is basically linear increasing. Fixing voltage, high energy electron density decreases with the increase in the distance between tip and plate. When the voltage and the distance between tip and plate are fixed, the high energy electron density increases with the decrease in the curvature radius of needle tip. These results are of great importance for the study of plasma parameters of corona discharge.

  6. Protein corona composition of gold nanoparticles/nanorods affects amyloid beta fibrillation process

    NASA Astrophysics Data System (ADS)

    Mirsadeghi, Somayeh; Dinarvand, Rassoul; Ghahremani, Mohammad Hossein; Hormozi-Nezhad, Mohammad Reza; Mahmoudi, Zohreh; Hajipour, Mohammad Javad; Atyabi, Fatemeh; Ghavami, Mahdi; Mahmoudi, Morteza

    2015-03-01

    Protein fibrillation process (e.g., from amyloid beta (Aβ) and α-synuclein) is the main cause of several catastrophic neurodegenerative diseases such as Alzheimer's and Parkinson diseases. During the past few decades, nanoparticles (NPs) were recognized as one of the most promising tools for inhibiting the progress of the disease by controlling the fibrillation kinetic process; for instance, gold NPs have a strong capability to inhibit Aβ fibrillations. It is now well understood that a layer of biomolecules would cover the surface of NPs (so called ``protein corona'') upon the interaction of NPs with protein sources. Due to the fact that the biological species (e.g., cells and amyloidal proteins) ``see'' the protein corona coated NPs rather than the pristine coated particles, one should monitor the fibrillation process of amyloidal proteins in the presence of corona coated NPs (and not pristine coated ones). Therefore, the previously obtained data on NPs effects on the fibrillation process should be modified to achieve a more reliable and predictable in vivo results. Herein, we probed the effects of various gold NPs (with different sizes and shapes) on the fibrillation process of Aβ in the presence and absence of protein sources (i.e., serum and plasma). We found that the protein corona formed a shell at the surface of gold NPs, regardless of their size and shape, reducing the access of Aβ to the gold inhibitory surface and, therefore, affecting the rate of Aβ fibril formation. More specifically, the anti-fibrillation potencies of various corona coated gold NPs were strongly dependent on the protein source and their concentrations (10% serum/plasma (simulation of an in vitro milieu) and 100% serum/plasma (simulation of an in vivo milieu)).Protein fibrillation process (e.g., from amyloid beta (Aβ) and α-synuclein) is the main cause of several catastrophic neurodegenerative diseases such as Alzheimer's and Parkinson diseases. During the past few decades

  7. Structure and Dynamics of the Solar Corona

    NASA Technical Reports Server (NTRS)

    Schnack, D. D.

    1994-01-01

    Advanced computational techniques were used to study solar coronal heating and coronal mass ejections. A three dimensional, time dependent resistive magnetohydrodynamic code was used to study the dynamic response of a model corona to continuous, slow, random magnetic footpoint displacements in the photosphere. Three dimensional numerical simulations of the response of the corona to simple smooth braiding flows in the photosphere were calculated to illustrate and understand the spontaneous formation of current filaments. Two dimensional steady state helmet streamer configurations were obtained by determining the time asymptotic state of the interaction of an initially one dimensinal transponic solar wind with a spherical potential dipole field. The disruption of the steady state helmet streamer configuration was studied as a response to shearing of the magnetic footpoints of the closed field lines under the helmet.

  8. 48 CFR 3452.232-71 - Incremental funding.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Incremental funding. 3452....232-71 Incremental funding. As prescribed in 3432.705-2, insert the following provision in solicitations if a cost-reimbursement contract using incremental funding is contemplated: Incremental Funding...

  9. 48 CFR 3452.232-71 - Incremental funding.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Incremental funding. 3452....232-71 Incremental funding. As prescribed in 3432.705-2, insert the following provision in solicitations if a cost-reimbursement contract using incremental funding is contemplated: Incremental Funding...

  10. 48 CFR 3452.232-71 - Incremental funding.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Incremental funding. 3452....232-71 Incremental funding. As prescribed in 3432.705-2, insert the following provision in solicitations if a cost-reimbursement contract using incremental funding is contemplated: Incremental Funding...

  11. 48 CFR 3452.232-71 - Incremental funding.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Incremental funding. 3452....232-71 Incremental funding. As prescribed in 3432.705-2, insert the following provision in solicitations if a cost-reimbursement contract using incremental funding is contemplated: Incremental Funding...

  12. Characteristics of corona impulses from insulated wires subjected to high ac voltages

    NASA Technical Reports Server (NTRS)

    Doreswamy, C. V.; Crowell, C. S.

    1976-01-01

    Corona discharges arise due to ionization of air or gas subject to high electric fields. The free electrons and ions contained in these discharges interact with molecules of insulating materials, resulting in chemical changes and destroying the electrical insulating properties. The paper describes some results of measurements aimed at determining corona pulse waveforms, their repetition rate, and amplitude distribution during various randomly-sampled identical time periods of a 60-Hz high-voltage wave. Described are properties of positive and negative corona impulses generated from typical conductors at various test high voltages. A possible method for calculating the energies, densities, and electromagnetic interferences by making use of these results is suggested.

  13. 14 CFR 1260.53 - Incremental funding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Incremental funding. 1260.53 Section 1260.53 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Special Conditions § 1260.53 Incremental funding. Incremental Funding October 2000 (a...

  14. 14 CFR 1260.53 - Incremental funding.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Incremental funding. 1260.53 Section 1260.53 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Special Conditions § 1260.53 Incremental funding. Incremental Funding October 2000 (a...

  15. 14 CFR 1260.53 - Incremental funding.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Incremental funding. 1260.53 Section 1260.53 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Special Conditions § 1260.53 Incremental funding. Incremental Funding October 2000 (a...

  16. Modeling corona sheath dynamics and effects

    NASA Astrophysics Data System (ADS)

    Carlson, B.; Lehtinen, N. G.

    2016-12-01

    The conductive lightning channel is only a centimeter or so in diameter, but charge deposited along such a narrow channel produces a large electric field that drives corona discharge in nearby air, carrying the charge outward several meters. The formation of this "corona sheath" affects a wide range of observable properties of lightning, including the overall charge carried by the channel, the shape, speed, and attenuation of impulsive currents, and the possibility of x-ray production. Simplified electrostatic and electrodynamic models of the formation of the sheath will be discussed, with results given including regions near the tip of a hypothetical channel. These results suggest that the sheath initially expands very rapidly, limiting the lifetime of the intense fields nearest the channel. The expansion gradually slows as the fields decrease, but under certain circumstances a large-scale streamer-like process can lead to enhancement of electric fields displaced from the tip of the channel, possibly suggesting a mechanism for space stem formation and leader stepping.

  17. Protein-targeted corona phase molecular recognition

    PubMed Central

    Bisker, Gili; Dong, Juyao; Park, Hoyoung D.; Iverson, Nicole M.; Ahn, Jiyoung; Nelson, Justin T.; Landry, Markita P.; Kruss, Sebastian; Strano, Michael S.

    2016-01-01

    Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated by the quenching kinetics. The fibrinogen recognition also occurs in serum environment, at the clinically relevant fibrinogen concentrations in the human blood. These results open new avenues for synthetic, non-biological antibody analogues that recognize biological macromolecules, and hold great promise for medical and clinical applications. PMID:26742890

  18. Corona emission thresholds for three types of hydrometeor interaction in thunderclouds

    NASA Astrophysics Data System (ADS)

    Blyth, A. M.; Christian, H. J.; Latham, J.

    1998-06-01

    Laboratory studies have been conducted of the conditions under which glancing collisions, at relative velocities V characteristic of those occurring in thunderstorms, of three types of hydrometeor pairs of precipitation dimension (such as (1) warm drop pairs, (2) supercooled drop pairs, and (3) a supercooled drop and a graupel pellet) produce a corona discharge in an electric field E. In each case, the observed corona is emitted at the tip of an ephemeral liquid filament, of length greater than the dimensions of the interacting hydrometeors, drawn out during each interaction. For each type of hydrometeor pair, the probability f that corona was produced during an interaction increased steadily from zero for increasing values of E above about 150 kV/m, and was significantly in excess of 50% for values of E = 400 kV/m, which is probably about the maximum ambient value occurring in a thunderstorm. We conclude that if the associated hydrometeors are present in strongly electrified regions of thunderstorms (unlikely for interaction type 1 but manifestly possible for types 2 and 3, corona initiation leading to the production of lightning could result from each of the three types of interaction studied.

  19. DC corona ozone generation enhanced by TiO2 photocatalyst

    NASA Astrophysics Data System (ADS)

    Pekã¡Rek, S.

    2008-12-01

    Non-thermal electrical discharges, such as corona discharge are apart of the source of ozone, charged, and excited species and acoustic noise also the source of electromagnetic radiation of different wavelengths. The important component of this radiation from the standpoint of photocatalyst activation is the ultraviolet radiation. We studied the role of UV radiation on corona discharge ozone production by placing the titanium dioxide photocatalyst into the discharge region. We used hollow needle to mesh DC corona discharge at atmospheric pressure with TiO2 globules on the mesh. The discharge was enhanced by the flow of air through the needle. We found that for the needle biased negatively addition of TiO2 photocatalyst on the mesh electrode drastically increases discharge ozone production as well as the ozone production yield. These quantities are also influenced by the mass of the used photocatalyst and its distribution in the discharge chamber.

  20. Surface modification of polyethylene/graphene composite using corona discharge

    NASA Astrophysics Data System (ADS)

    Popelka, Anton; Noorunnisa Khanam, P.; AlMaadeed, Mariam Ali

    2018-03-01

    Polyethylene/graphene composites are suitable for electromagnetic interference shielding applications and are often fabricated as sandwich structures. However, the hydrophobic character of these composites can lead to delamination. Corona treatment was used to enhance the surface hydrophilicity of composites prepared from linear low-density polyethylene (LLDPE) and graphene nanoplatelets (GNPs) with different content (2, 4, 6, and 8 wt.%). This enhancement of wettability also led to good adhesion properties. The presence of GNPs in LLDPE had a positive effect on the surface properties after corona treatment. The surface free energy of the LLDPE/GNP composites increased by almost 64.6% for 2 wt.% of GNPs in the LLDPE/GNP composite, while the surface free energy of neat LLDPE increased by only 38.1%. The best improvement in adhesion properties after corona treatment was observed for 2 wt.% of GNPs in the LLDPE/GNP composite, while peel resistance increased by 137.9%. Various analytical techniques and methods proved that the changes in the surface morphology and chemical composition of the LLDPE/GNP composite after this treatment resulted in an improvement of adhesion.

  1. Simulation of the AC corona phenomenon with experimental validation

    NASA Astrophysics Data System (ADS)

    Villa, Andrea; Barbieri, Luca; Marco, Gondola; Malgesini, Roberto; Leon-Garzon, Andres R.

    2017-11-01

    The corona effect, and in particular the Trichel phenomenon, is an important aspect of plasma physics with many technical applications, such as pollution reduction, surface and medical treatments. This phenomenon is also associated with components used in the power industry where it is, in many cases, the source of electro-magnetic disturbance, noise and production of undesired chemically active species. Despite the power industry to date using mainly alternating current (AC) transmission, most of the studies related to the corona effect have been carried out with direct current (DC) sources. Therefore, there is technical interest in validating numerical codes capable of simulating the AC phenomenon. In this work we describe a set of partial differential equations that are comprehensive enough to reproduce the distinctive features of the corona in an AC regime. The model embeds some selectable chemical databases, comprising tens of chemical species and hundreds of reactions, the thermal dynamics of neutral species and photoionization. A large set of parameters—deduced from experiments and numerical estimations—are compared, to assess the effectiveness of the proposed approach.

  2. 14 CFR 1260.53 - Incremental funding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Incremental funding. 1260.53 Section 1260.53 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Special Conditions § 1260.53 Incremental funding. Incremental Funding October 2000 (a) Only $___ of the...

  3. Comparison of reconnection in magnetosphere and solar corona

    NASA Astrophysics Data System (ADS)

    Imada, Shinsuke; Hirai, Mariko; Isobe, Hiroaki; Oka, Mitsuo; Watanabe, Kyoko; Minoshima, Takashi

    One of the most famous rapid energy conversion mechanisms in space is a magnetic reconnec-tion. The general concept of a magnetic reconnection is that the rapid energy conversion from magnetic field energy to thermal energy, kinetic energy or non-thermal particle energy. The understanding of rapid energy conversion rates from magnetic field energy to other energy is the fundamental and essential problem in the space physics. One of the important goals for studying magnetic reconnection is to answer what plasma condition/parameter controls the energy conversion rates. Earth's magnetotail has been paid much attention to discuss a mag-netic reconnection, because we can discuss magnetic reconnection characteristics in detail with direct in-situ observation. Recently, solar atmosphere has been focused as a space laboratory for magnetic reconnection because of its variety in plasma condition. So far considerable effort has been devoted toward understanding the energy conversion rates of magnetic reconnection, and various typical features associated with magnetic reconnection have been observed in the Earth's magnetotail and the solar corona. In this talk, we first introduce the variety of plasma condition/parameter in solar corona and Earth's magnetotail. Later, we discuss what plasma condition/parameter controls the energy conversion from magnetic field to especially non-thermal particle. To compare non-thermal electron and ion acceleration in magnetic reconnection, we used Hard X-ray (electron) /Neu-tron monitor (ion) for solar corona and Geotail in-situ measurement (electron and ion) for magnetoatil. We found both of electron and ion accelerations are roughly controlled by re-connection electric field (reconnection rate). However, some detail points are different in ion and electron acceleration. Further, we will discuss what is the major difference between solar corona and Earth's magnetotail for particle acceleration.

  4. A GLOBAL GALACTIC DYNAMO WITH A CORONA CONSTRAINED BY RELATIVE HELICITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Prasad, A.; Mangalam, A., E-mail: avijeet@iiap.res.in, E-mail: mangalam@iiap.res.in

    We present a model for a global axisymmetric turbulent dynamo operating in a galaxy with a corona that treats the parameters of turbulence driven by supernovae and by magneto-rotational instability under a common formalism. The nonlinear quenching of the dynamo is alleviated by the inclusion of small-scale advective and diffusive magnetic helicity fluxes, which allow the gauge-invariant magnetic helicity to be transferred outside the disk and consequently to build up a corona during the course of dynamo action. The time-dependent dynamo equations are expressed in a separable form and solved through an eigenvector expansion constructed using the steady-state solutions ofmore » the dynamo equation. The parametric evolution of the dynamo solution allows us to estimate the final structure of the global magnetic field and the saturated value of the turbulence parameter α{sub m}, even before solving the dynamical equations for evolution of magnetic fields in the disk and the corona, along with α-quenching. We then solve these equations simultaneously to study the saturation of the large-scale magnetic field, its dependence on the small-scale magnetic helicity fluxes, and the corresponding evolution of the force-free field in the corona. The quadrupolar large-scale magnetic field in the disk is found to reach equipartition strength within a timescale of 1 Gyr. The large-scale magnetic field in the corona obtained is much weaker than the field inside the disk and has only a weak impact on the dynamo operation.« less

  5. Threaded-Field-Line Model for the Transition Region and Solar Corona

    NASA Astrophysics Data System (ADS)

    Sokolov, I.; van der Holst, B.; Gombosi, T. I.

    2014-12-01

    In numerical simulations of the solar corona, both for the ambient state and especially for dynamical processes the most computational resources are spent for maintaining the numerical solution in the Low Solar Corona and in the transition region, where the temperature gradients are very sharp and the magnetic field has a complicated topology. The degraded computational efficiency is caused by the need in a highest resolution as well as the use of the fully three-dimensional implicit solver for electron heat conduction. On the other hand, the physical nature of the processes involved is rather simple (which still does not facilitate the numerical methods) as long as the heat fluxes as well as slow plasma motional velocities are aligned with the magnetic field. The Alfven wave turbulence, which is often believed to be the main driver of the solar wind and the main source of the coronal heating, is characterized by the Poynting flux of the waves, which is also aligned with the magnetic field. Therefore, the plasma state in any point of the three-dimensional grid in the Low Solar Corona can be found by solving a set of one-dimensional equations for the magnetic field line ("thread"), which passes through this point and connects it to the chromosphere and to the global Solar Corona. In the present paper we describe an innovative computational technology based upon the use of the magnetic-field-line-threads to forlmulate the boundary condition for the global solar corona model which traces the connection of each boundary point to the cromosphere along the threads.

  6. 18 CFR 154.309 - Incremental expansions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Incremental expansions. 154.309 Section 154.309 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Changes § 154.309 Incremental expansions. (a) For every expansion for which incremental rates are charged...

  7. 18 CFR 154.309 - Incremental expansions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Incremental expansions. 154.309 Section 154.309 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Changes § 154.309 Incremental expansions. (a) For every expansion for which incremental rates are charged...

  8. 18 CFR 154.309 - Incremental expansions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Incremental expansions. 154.309 Section 154.309 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Changes § 154.309 Incremental expansions. (a) For every expansion for which incremental rates are charged...

  9. 18 CFR 154.309 - Incremental expansions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Incremental expansions. 154.309 Section 154.309 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Changes § 154.309 Incremental expansions. (a) For every expansion for which incremental rates are charged...

  10. 18 CFR 154.309 - Incremental expansions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Incremental expansions. 154.309 Section 154.309 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Changes § 154.309 Incremental expansions. (a) For every expansion for which incremental rates are charged...

  11. Alfven Profile in the Lower Corona: Implications for Shock Formation

    NASA Astrophysics Data System (ADS)

    Evans, R. M.; Opher, M.; Manchester, W. B.; Velli, M.; Gombosi, T. I.

    2007-12-01

    Recent events (e.g. Tylka et al. 2005) indicate that CME-driven shocks can form at 1-3 solar radii and are responsible for the GeV/nucleon energies observed in some ground level solar energetic particle events. The formation of shocks depends crucially on the background solar wind environment, in particular on the profile of the background Alfvén speed in the corona. Significant strides have been made in the effort to develop realistic models of CME events; however, there is no consensus as to the profile of the Alfvén speed in the lower corona. Here we provide an overview of ten state-of-the-art models, which includes various methods to model magnetic field and density, as well as different strategies for accelerating the solar wind. We present the Alfvén speed profile for each model in the lower corona. We find that the "valley" and "hump" structures anticipated by Mann et al. (2003) are sometimes present, but in some models the Alfvén profiles drop off quickly. We discuss the implications of these profiles, such as whether it will allow a shock to form, dissipate, and form again (i.e. multiple shocks). Our study indicates that it is crucial to establish the Alfvén speed as a function of height before determining if shocks can form in the lower corona.

  12. Silver nanoparticle-human hemoglobin interface: time evolution of the corona formation and interaction phenomenon.

    PubMed

    Bhunia, A K; Kamilya, T; Saha, S

    2017-01-01

    In this paper, we have used spectroscopic and electron microscopic analysis to monitor the time evolution of the silver nanoparticles (Ag NP)-human hemoglobin (Hb) corona formation and to characterize the interaction of the Ag NPs with Hb. The time constants for surface plasmon resonance binding and reorganization are found to be 9.51 and 118.48 min, respectively. The drop of surface charge and the increase of the hydrodynamic diameter indicated the corona of Hb on the Ag NP surface. The auto correlation function is found to broaden with the increasing time of the corona formation. Surface zeta potential revealed that positively charged Hb interact electrostatically with negatively charged Ag NP surfaces. The change in α helix and β sheet depends on the corona formation time. The visualization of the Hb corona from HRTEM showed large number of Hb domains aggregate containing essentially Ag NPs and without Ag NPs. Emission study showed the tertiary deformation, energy transfer, nature of interaction and quenching under three different temperatures.

  13. Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid.

    PubMed

    Kumar, Abhinav; Bicer, Elif Melis; Morgan, Anna Babin; Pfeffer, Paul E; Monopoli, Marco; Dawson, Kenneth A; Eriksson, Jonny; Edwards, Katarina; Lynham, Steven; Arno, Matthew; Behndig, Annelie F; Blomberg, Anders; Somers, Graham; Hassall, Dave; Dailey, Lea Ann; Forbes, Ben; Mudway, Ian S

    2016-05-01

    When inhaled nanoparticles deposit in the lungs, they transit through respiratory tract lining fluid (RTLF) acquiring a biomolecular corona reflecting the interaction of the RTLF with the nanomaterial surface. Label-free snapshot proteomics was used to generate semi-quantitative profiles of corona proteins formed around silica (SiO2) and poly(vinyl) acetate (PVAc) nanoparticles in RTLF, the latter employed as an archetype drug delivery vehicle. The evolved PVAc corona was significantly enriched compared to that observed on SiO2 nanoparticles (698 vs. 429 proteins identified); however both coronas contained a substantial contribution from innate immunity proteins, including surfactant protein A, napsin A and complement (C1q and C3) proteins. Functional protein classification supports the hypothesis that corona formation in RTLF constitutes opsonisation, preparing particles for phagocytosis and clearance from the lungs. These data highlight how an understanding of the evolved corona is necessary for the design of inhaled nanomedicines with acceptable safety and tailored clearance profiles. Inhaled nanoparticles often acquire a layer of protein corona while they go through the respiratory tract. Here, the authors investigated the identity of these proteins. The proper identification would improve the understanding of the use of inhaled nanoparticles in future therapeutics. Copyright © 2016. Published by Elsevier Inc.

  14. 14 CFR 1274.918 - Incremental funding.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Incremental funding. 1274.918 Section 1274... COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.918 Incremental funding. Incremental Funding... Agreement, as required, until it is fully funded. Any work beyond the funding limit will be at the recipient...

  15. 14 CFR 1274.918 - Incremental funding.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Incremental funding. 1274.918 Section 1274... COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.918 Incremental funding. Incremental Funding... Agreement, as required, until it is fully funded. Any work beyond the funding limit will be at the recipient...

  16. 14 CFR 1274.918 - Incremental funding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Incremental funding. 1274.918 Section 1274... COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.918 Incremental funding. Incremental Funding... Agreement, as required, until it is fully funded. Any work beyond the funding limit will be at the recipient...

  17. 14 CFR 1274.918 - Incremental funding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Incremental funding. 1274.918 Section 1274... COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.918 Incremental funding. Incremental Funding... Agreement, as required, until it is fully funded. Any work beyond the funding limit will be at the recipient...

  18. OH radicals generated by DC corona discharge for improving the pulsed discharge desulfuration efficiency.

    PubMed

    Li, Jie; Li, Guo-feng; Wu, Yan; Wang, Ning-hui; Huang, Qiu-nan

    2004-01-01

    Positive DC corona discharge is formed with needle-plate electrode configuration, in which the water vapor is ejected though the needle points. The purpose is to increase the numbers of the water-based radicals, ionize the water molecule and improve the desulfuration efficiency of pulsed corona reactor. The water ions were determined by four stages molecular beam mass spectrometer and diagnose the water-based radicals by emission spectrograph. A conclusion on formation of ions and radicals with DC corona discharges can be drawn.

  19. International Space Station Increment Operations Services

    NASA Astrophysics Data System (ADS)

    Michaelis, Horst; Sielaff, Christian

    2002-01-01

    The Industrial Operator (IO) has defined End-to-End services to perform efficiently all required operations tasks for the Manned Space Program (MSP) as agreed during the Ministerial Council in Edinburgh in November 2001. Those services are the result of a detailed task analysis based on the operations processes as derived from the Space Station Program Implementation Plans (SPIP) and defined in the Operations Processes Documents (OPD). These services are related to ISS Increment Operations and ATV Mission Operations. Each of these End-to-End services is typically characterised by the following properties: It has a clearly defined starting point, where all requirements on the end-product are fixed and associated performance metrics of the customer are well defined. It has a clearly defined ending point, when the product or service is delivered to the customer and accepted by him, according to the performance metrics defined at the start point. The implementation of the process might be restricted by external boundary conditions and constraints mutually agreed with the customer. As far as those are respected the IO has the free choice to select methods and means of implementation. The ISS Increment Operations Service (IOS) activities required for the MSP Exploitation program cover the complete increment specific cycle starting with the support to strategic planning and ending with the post increment evaluation. These activities are divided into sub-services including the following tasks: - ISS Planning Support covering the support to strategic and tactical planning up to the generation - Development &Payload Integration Support - ISS Increment Preparation - ISS Increment Execution These processes are tight together by the Increment Integration Management, which provides the planning and scheduling of all activities as well as the technical management of the overall process . The paper describes the entire End-to-End ISS Increment Operations service and the

  20. The Corona Dentis: Description of an Anatomic Variant with Technical Implications for Anterior Odontoid Screw Placement.

    PubMed

    Alonso, Fernando; Iwanaga, Joe; Chapman, Jens R; Oskouian, Rod J; Tubbs, R Shane

    2017-08-01

    Type 2 odontoid fractures are the most common cervical fractures among the elderly. Neurologic deficit is usually caused by myelopathy as a result of posterior dens migration. Direct anterior screw placement provides stabilization and can preserve C1-C2 movement. The presence of a bony excrescence on the anterior superior tip of the dens may lead to placement of a screw of incorrect length. Twenty C2 dry specimens were examined for the presence of a corona dentis, which is a bony excrescence in the coronal plane near the apex of the dens. When identified, measurements of the corona dentis were performed using calipers and a ruler. In addition, anteroposterior (AP) and lateral fluoroscopy was performed on all specimens found to have a corona dentis. A corona dentis was found on 20% of our C2 specimens and had an average width of 9 mm and an average height of 4.5 mm. The average width of the dens did not vary as the normal tip of the dens transitioned into the coronae. In no specimen did the corona dentis seem to be composed of trabecular bone and it was seen as a superior projection of cortical bone on fluoroscopy. On fluoroscopy, the corona dentis could be identified on a true AP projection. In angulated AP views, fluoroscopic images overestimated the length of the corona dentis. We describe a new entity termed the corona dentis because of its crownlike feature. It is a superior cortical bone protrusion and should be noted as a variant of the dens during anterior odontoid screw placement. Its propensity to increase the height of the dens markedly can lead to higher rates of neurologic deficits during type 2 odontoid fractures if not appreciated. A true AP view is critical for correct screw size placement. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Transformation of soybean Gy3 gene into Artemisaarenaria mediated by corona discharge

    NASA Astrophysics Data System (ADS)

    Chao, Lu-meng; Na, Ri; Xue, Dan; Xu, Yongze; Liu, Teng

    2013-03-01

    In order to improve the protein content of desert plant, a method of genetic transformation mediated by corona discharge was established. Artemisia seeds were processed in corona electric field for 120 min at 12 kV, and then soaked in 0.1 SSC media that contained Soybean Gy3 gene DNA to incubate for 12 h at 26 °C. Finally the seeds were inoculated on the differentiation medium. Polymerase Chain Reaction (PCR) and Reverse Transcription Polymerase Chain Reaction (RT-PCR) detection showed that the Soybean Gy3 gene had been successfully introduced into genomic DNA of the regenerated plants of Artemisaarenaria. The study provided a new way for corona discharge in plant genetic modification.

  2. Corona discharges and their effect on lightning attachment revisited: Upward leader initiation and downward leader interception

    NASA Astrophysics Data System (ADS)

    Becerra, Marley

    2014-11-01

    Previous studies have suggested the possibility of using glow corona discharges to control the frequency of lightning flashes to grounded objects. In order to revisit the theoretical basis of this proposal, the self-consistent leader inception and propagation model - SLIM - is used together with a two-dimensional glow corona drift model. The analysis is performed to quantify the effect of glow corona generated at the tip of ground-based objects on the initiation and propagation of upward positive connecting leaders under the influence of downward lightning leaders. It is found that the presence of glow corona does not influence the performance of Franklin lightning rods shorter than 15 m, while it slightly reduces the lateral distance of rods up to 60 m tall by a maximum of 10%. Furthermore, the results indicate that it is not possible to suppress the initiation of upward connecting leaders by means of glow corona. It is found instead that unconventional lightning protection systems based on the generation of glow corona attract downward lightning flashes in a similar way as a standard lightning rod with the same height.

  3. Size and surface functionalization of iron oxide nanoparticles influence the composition and dynamic nature of their protein corona.

    PubMed

    Ashby, Jonathan; Pan, Songqin; Zhong, Wenwan

    2014-09-10

    Nanoparticles (NPs) adsorb proteins when in the biological matrix, and the resulted protein corona could affect NP-cell interactions. The corona has a dynamic nature with the adsorbed proteins constantly exchanging with the free proteins in the matrix at various rates. The rapidly exchanging proteins compose the soft corona, which responds more dynamically to environment changes than the hard corona established by the ones with slow exchange rates. In the present study, the corona formed on the superparamagnetic iron oxide NPs (SPIONs) in human serum was studied by flow field-flow fractionation and ultracentrifugation, which rapidly differentiated the corona proteins based on their exchange rates. By varying the surface hydrophobicity of the SPIONs with a core size around 10 nm, we found out that, the more hydrophobic surface ligand attracted proteins with higher surface hydrophobicity and formed a more dynamic corona with a larger portion of the involved proteins with fast exchange rates. Increasing the core diameter of the SPIONs but keeping the surface ligand the same could also result in a more dynamic corona. A brief investigation of the effect on the cellular uptake of SPIONs using one selected corona protein, transferrin, was conducted. The result showed that, only the stably bound transferrin could significantly enhance cellular uptake, while transferrin bound in a dynamic nature had negligible impact. Our study has led to a better understanding of the relationship between the particle properties and the dynamic nature of the corona, which can help with design of nanomaterials with higher biocompatibility and higher efficacy in biosystems for biomedical applications.

  4. Size and Surface Functionalization of Iron Oxide Nanoparticles Influence the Composition and Dynamic Nature of Their Protein Corona

    PubMed Central

    2015-01-01

    Nanoparticles (NPs) adsorb proteins when in the biological matrix, and the resulted protein corona could affect NP-cell interactions. The corona has a dynamic nature with the adsorbed proteins constantly exchanging with the free proteins in the matrix at various rates. The rapidly exchanging proteins compose the soft corona, which responds more dynamically to environment changes than the hard corona established by the ones with slow exchange rates. In the present study, the corona formed on the superparamagnetic iron oxide NPs (SPIONs) in human serum was studied by flow field-flow fractionation and ultracentrifugation, which rapidly differentiated the corona proteins based on their exchange rates. By varying the surface hydrophobicity of the SPIONs with a core size around 10 nm, we found out that, the more hydrophobic surface ligand attracted proteins with higher surface hydrophobicity and formed a more dynamic corona with a larger portion of the involved proteins with fast exchange rates. Increasing the core diameter of the SPIONs but keeping the surface ligand the same could also result in a more dynamic corona. A brief investigation of the effect on the cellular uptake of SPIONs using one selected corona protein, transferrin, was conducted. The result showed that, only the stably bound transferrin could significantly enhance cellular uptake, while transferrin bound in a dynamic nature had negligible impact. Our study has led to a better understanding of the relationship between the particle properties and the dynamic nature of the corona, which can help with design of nanomaterials with higher biocompatibility and higher efficacy in biosystems for biomedical applications. PMID:25144382

  5. Hi-C Observations of an Active Region Corona, and Investigation of the Underlying Magnetic Structure

    NASA Technical Reports Server (NTRS)

    Tiwari, S. K.; Alexander, C. E.; Winebarger, A.; Moore, R. L.

    2014-01-01

    The solar corona is much hotter (>=10(exp 6) K) than its surface (approx 6000 K), puzzling astrophysicists for several decades. Active region (AR) corona is again hotter than the quiet Sun (QS) corona by a factor of 4-10. The most widely accepted mechanism that could heat the active region corona is the energy release by current dissipation via reconnection of braided magnetic field structure, first proposed by E. N. Parker three decades ago. The first observational evidence for this mechanism has only recently been presented by Cirtain et al. by using High-resolution Coronal Imager (Hi-C) observations of an AR corona at a spatial resolution of 0.2 arcsec, which is required to resolve the coronal loops, and was not available before the rocket flight of Hi-C in July 2012. The Hi-C project is led by NASA/MSFC. In the case of the QS, work done by convection/granulation on the inter-granular feet of the coronal field lines translates into the heat observed in the corona. In the case of the AR, as here, there could be flux emergence, cancellation/submergence, or shear flows generating large stress and tension in coronal field loops which is released as heat in the corona. We are currently investigating the changes taking place in photospheric feet of the magnetic field involved with brightenings in the Hi-C AR corona. For this purpose, we are also using SDO/AIA data of +/- 2 hours around the 5 minutes Hi-C flight. In the present talk, I will first summarize some of the results of the Hi-C observations and then present some results from our recent analysis on what photospheric processes feed the magnetic energy that dissipates into heat in coronal loops.

  6. [Removal of SO2 from flue gas by water vapor DC corona discharge].

    PubMed

    Sun, Ming; Wu, Yan

    2006-07-01

    The influence of several factors on removal rate of SO2 from flue gas in unsaturated water vapor DC corona discharge was researched. Furthermore, the experiments of the removal rate of SO2 in pulsed discharge increased by water vapor DC corona discharge plasma were conducted. The experiment system is supplied with multi-nozzle-plate electrodes and the flow of simulated flue gas is under 70 m3/h. The results show that removal rate of SO2 can be improved by increasing the concentration of water vapor, intensity of electric field or decreasing flow of simulated flue gas. In unsaturated water vapor DC corona discharge, removal rate of SO2 can be improved by 10%, when NH3 is added as NH3 and SO2 is in a mole ratio of two to one, it can reach 60%. The removal rate of SO2 can be increased by 5% in pulsed corona discharge and reach above 90%.

  7. Corona-glow transition in the atmospheric pressure RF-excited plasma needle

    NASA Astrophysics Data System (ADS)

    Sakiyama, Y.; Graves, D. B.

    2006-08-01

    We present clear evidence of two different discharge modes of the atmospheric pressure RF-excited plasma needle and the transition mechanism by the finite element method. The gas used is helium with 0.1% nitrogen addition. The needle has a point-to-plane geometry with a radius of 30 µm at the tip, 150 µm at the base and an inter-electrode gap of 1 mm. We employ the one-moment fluid model with the local field approximation. Our simulation results indicate that the plasma needle operates as a corona discharge at low power and that the discharge mode transitions to a glow discharge at a critical power. The discharge power increases but the discharge voltage drops abruptly by a factor of about 2 in the corona-glow transition. The plasma density and ionization is confined near the needle tip in corona-mode while it spreads back along the needle surface in glow-mode. The corona-glow transition is also characterized by a dramatic decrease in sheath thickness and an order of magnitude increase in plasma density and volume-averaged ionization. The transition is observed whether or not secondary electron emission is included in the model, and therefore we suggest that this is not an α -γ transition.

  8. Constructing increment-decrement life tables.

    PubMed

    Schoen, R

    1975-05-01

    A life table model which can recognize increments (or entrants) as well as decrements has proven to be of considerable value in the analysis of marital status patterns, labor force participation patterns, and other areas of substantive interest. Nonetheless, relatively little work has been done on the methodology of increment-decrement (or combined) life tables. The present paper reviews the general, recursive solution of Schoen and Nelson (1974), develops explicit solutions for three cases of particular interest, and compares alternative approaches to the construction of increment-decrement tables.

  9. The fate of a designed protein corona on nanoparticles in vitro and in vivo.

    PubMed

    Bargheer, Denise; Nielsen, Julius; Gébel, Gabriella; Heine, Markus; Salmen, Sunhild C; Stauber, Roland; Weller, Horst; Heeren, Joerg; Nielsen, Peter

    2015-01-01

    A variety of monodisperse superparamagnetic iron oxide particles (SPIOs) was designed in which the surface was modified by PEGylation with mono- or bifunctional poly(ethylene oxide)amines (PEG). Using (125)I-labeled test proteins (transferrin, albumin), the binding and exchange of corona proteins was studied first in vitro. Incubation with (125)I-transferrin showed that with increasing grade of PEGylation the binding was substantially diminished without a difference between simply adsorbed and covalently bound protein. However, after incubation with excess albumin and subsequently whole plasma, transferrin from the preformed transferrin corona was more and more lost from SPIOs in the case of adsorbed proteins. If non-labeled transferrin was used as preformed corona and excess (125)I-labeled albumin was added to the reaction mixtures with different SPIOs, a substantial amount of label was bound to the particles with initially adsorbed transferrin but little or even zero with covalently bound transferrin. These in vitro experiments show a clear difference in the stability of a preformed hard corona with adsorbed or covalently bound protein. This difference seems, however, to be of minor importance in vivo when polymer-coated (59)Fe-SPIOs with adsorbed or covalently bound (125)I-labeled mouse transferrin were injected intravenously in mice. With both protein coronae the (59)Fe/(125)I-labelled particles were cleared from the blood stream within 30 min and appeared in the liver and spleen to a large extent (>90%). In addition, after 2 h already half of the (125)I-labeled transferrin from both nanodevices was recycled back into the plasma and into tissue. This study confirms that adsorbed transferrin from a preformed protein corona is efficiently taken up by cells. It is also highlighted that a radiolabelling technique described in this study may be of value to investigate the role of protein corona formation in vivo for the respective nanoparticle uptake.

  10. Protein corona and nanoparticles: how can we investigate on?

    PubMed

    Pederzoli, Francesca; Tosi, Giovanni; Vandelli, Maria Angela; Belletti, Daniela; Forni, Flavio; Ruozi, Barbara

    2017-11-01

    Nanoparticles (NPs) represent one of the most promising tools for drug-targeting and drug-delivery. However, a deeper understanding of the complex dynamics that happen after their in vivo administration is required. Particularly, plasma proteins tend to associate to NPs, forming a new surface named the 'protein corona' (PC). This surface is the most exposed as the 'visible side' of NPs and therefore, can have a strong impact on NP biodistribution, targeting efficacy and also toxicity. The PC consists of two poorly delimited layers, known as 'hard corona' (HC) and 'soft corona' (SC), that are affected by the complexity of the environment and the formed protein-surface equilibrium during in vivo blood circulation. The HC corona is formed by proteins strongly associated to the NPs, while the SC is an outer layer consisting of loosely bound proteins. Several studies attempted to investigate the HC, which is easier to be isolated, but yielded poor reproducibility, due to varying experimental conditions. As a consequence, full mapping of the HC for different NPs is still lacking. Moreover, the current knowledge on the SC, which may play a major role in the 'first' interaction of NPs once in vivo, is very limited, mainly due to the difficulties in preserving it after purification. Therefore, multi-disciplinary approaches leading to the obtainment of a major number of information about the PC and its properties is strongly needed to fully understand its impact and to better support a more safety and conscious application of nanotechnology in medicine. WIREs Nanomed Nanobiotechnol 2017, 9:e1467. doi: 10.1002/wnan.1467 For further resources related to this article, please visit the WIREs website. © 2017 Wiley Periodicals, Inc.

  11. NUMERICAL SIMULATIONS OF HELICITY CONDENSATION IN THE SOLAR CORONA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhao, L.; Zurbuchen, T. H.; DeVore, C. R.

    The helicity condensation model has been proposed by Antiochos to explain the observed smoothness of coronal loops and the observed buildup of magnetic shear at filament channels. The basic hypothesis of the model is that magnetic reconnection in the corona causes the magnetic stress injected by photospheric motions to collect only at those special locations where prominences are observed to form. In this work we present the first detailed quantitative MHD simulations of the reconnection evolution proposed by the helicity condensation model. We use the well-known ansatz of modeling the closed corona as an initially uniform field between two horizontalmore » photospheric plates. The system is driven by applying photospheric rotational flows that inject magnetic helicity into the corona. The flows are confined to a finite region on the photosphere so as to mimic the finite flux system of a bipolar active region, for example. The calculations demonstrate that, contrary to common belief, opposite helicity twists do not lead to significant reconnection in such a coronal system, whereas twists with the same sense of helicity do produce substantial reconnection. Furthermore, we find that for a given amount of helicity injected into the corona, the evolution of the magnetic shear is insensitive to whether the pattern of driving photospheric motions is fixed or quasi-random. In all cases, the shear propagates via reconnection to the boundary of the flow region while the total magnetic helicity is conserved, as predicted by the model. We discuss the implications of our results for solar observations and for future, more realistic simulations of the helicity condensation process.« less

  12. [Desulphurization with multi-needle-water film electrodes by corona discharge].

    PubMed

    Huang, Xu-ran; Li, Guo-feng; Li, Jie; Wu, Yan

    2008-09-01

    The study of this paper adopted stainless steel multi-needle as a high voltage electrode system, and water film as low voltage electrode. The electrodes were supplied with negative DC high voltage. Polluted gas containing sulfur dioxide (SO2) flowed into the corona discharge field from the center of the high voltage electrode system in an axis direction, then get across the water surface. Under the effect of corona discharge plasma and water absorption, SO2 was removed by converting it into sulfuric acid. The effect of the three factors which were the applied voltage, SO2 inlet concentration and duration of the exposure to the corona discharge on desulphurization efficiency has been studied mostly. Moreover, the concentrations of SO3(2-) and SO4(2-) ions in the water were measured and the mechanism of desulphurization was analyzed. The results showed that there was a synergistic effect on the removal of SO2 when combining corona discharge and water absorption, and both the desulphurization efficiency and the amount of sulfuric acid increased evidently. As the applied voltage and the duration increased, the desulphurization efficiency increased. Also, the SO2 inlet concentration had effect on desulphurization efficiency. When the SO2 inlet concentration was 430 x 10(-6), the voltage was 14.5 kV and the duration was 7.5 s, a desulphurization efficiency of more than 90% could be attained.

  13. Catastrophic cooling and cessation of heating in the solar corona

    NASA Astrophysics Data System (ADS)

    Peter, H.; Bingert, S.; Kamio, S.

    2012-01-01

    Context. Condensations in the more than 106 K hot corona of the Sun are commonly observed in the extreme ultraviolet (EUV). While their contribution to the total solar EUV radiation is still a matter of debate, these condensations certainly provide a valuable tool for studying the dynamic response of the corona to the heating processes. Aims: We investigate different distributions of energy input in time and space to investigate which process is most relevant for understanding these coronal condensations. Methods: For a comparison to observations we synthesize EUV emission from a time-dependent, one-dimensional model for coronal loops, where we employ two heating scenarios: simply shutting down the heating and a model where the heating is very concentrated at the loop footpoints, while keeping the total heat input constant. Results: The heating off/on model does not lead to significant EUV count rates that one observes with SDO/AIA. In contrast, the concentration of the heating near the footpoints leads to thermal non-equilibrium near the loop top resulting in the well-known catastrophic cooling. This process gives a good match to observations of coronal condensations. Conclusions: This shows that the corona needs a steady supply of energy to support the coronal plasma, even during coronal condensations. Otherwise the corona would drain very fast, too fast to even form a condensation. Movies are available in electronic form at http://www.aanda.org

  14. Depolarization current relaxation process of insulating dielectrics after corona poling under different charging conditions

    NASA Astrophysics Data System (ADS)

    Zhang, J. W.; Zhou, T. C.; Wang, J. X.; Yang, X. F.; Zhu, F.; Tian, L. M.; Liu, R. T.

    2017-10-01

    As an insulating dielectric, polyimide is favorable for the application of optoelectronics, electrical insulation system in electric power industry, insulating, and packaging materials in space aircraft, due to its excellent thermal, mechanical and electrical insulating stability. The charge storage profile of such insulating dielectric is utmost important to its application, when it is exposed to electron irradiation, high voltage corona discharge or other treatments. These treatments could induce changes in physical and chemical properties of treated samples. To investigate the charge storage mechanism of the insulating dielectrics after high-voltage corona discharge, the relaxation processes responsible for corona charged polyimide films under different poling conditions were analyzed by the Thermally Stimulated Discharge Currents method (TSDC). In the results of thermal relaxation process, the appearance of various peaks in TSDC spectra provided a deep insight into the molecular status in the dielectric material and reflected stored space charge relaxation process in the insulating polymers after corona discharge treatments. Furthermore, the different space charge distribution status under various poling temperature and different discharge voltage level were also investigated, which could partly reflect the influence of the ambiance condition on the functional dielectrics after corona poling.

  15. Effective lock-in strategy for proteomic analysis of corona complexes bound to amino-free ligands of gold nanoparticles.

    PubMed

    Zhou, Mi; Tang, Min; Li, Shuiming; Peng, Li; Huang, Haojun; Fang, Qihua; Liu, Zhao; Xie, Peng; Li, Gao; Zhou, Jian

    2018-06-21

    For specific applications, gold nanoparticles (GNPs) are commonly functionalized with various biological ligands, including amino-free ligands such as amino acids, peptides, proteins, and nucleic acids. Upon entering a biological fluid, the protein corona that forms around GNPs can conceal the targeting ligands and sterically hinder the functional properties. The protein corona is routinely prepared by standard centrifugation or sucrose cushion centrifugation. However, such methodologies are not applicable to the exclusive analysis of a ligand-binding protein corona. In this study, we first proposed a lock-in strategy based on a combination of rapid crosslinking and stringent washing. Cysteine was used as a model of amino-free ligands and attached to GNPs. After corona formation in the human plasma, GNP cysteine and corona proteins were quickly fixed by 5 s of crosslinking with 7.5% formaldehyde. After stringent washing using SDS buffer with sonication, the cysteine-bound proteins were effectively separated from unbound proteins. Qualitative and quantitative analyses using a mass spectrometry-based proteomics approach indicated that the protein composition of the cysteine-binding corona from the new method was significantly different from the composition of the whole corona from the two conventional methods. Furthermore, network and formaldehyde-linked site analyses of cysteine-binding proteins provided useful information toward a better knowledge of the behavior of protein-ligand and protein-protein interactions. Collectively, our new strategy has the capability to particularly characterize the protein composition of a cysteine-binding corona. The presented methodology in principal provides a generic way to analyze a nanoparticle corona bound to amino-free ligands and has the potential to decipher corona-masked ligand functions.

  16. Sterilisation of Hydroponic Culture Solution Contaminated by Fungi using an Atmospheric Pressure Corona Discharge

    NASA Astrophysics Data System (ADS)

    Mizukami, Kohji; Satoh, Kohki; Kanayama, Hiroshi; Itoh, Hidenori; Tagashira, Hiroaki; Shimozuma, Mitsuo; Okamoto, Hiroyuki; Takasaki, Satoko; Kinoshita, Muneshige

    The hydroponic culture solution contaminated by fungi is sterilised by a DC corona discharge, and the sterilisation characteristics are investigated in this work. A DC streamer corona discharge is generated at atmospheric pressure in air between needle clusters and a water bath containing contaminated solution by fungus such as Fusarium oxysporum f. sp. spinaciae or Fusarium sp.. It is found that the fungi are killed by the exposure of the corona discharge, and that the death rates of the fungi chiefly depend on the concentration of the hydroponic culture solutions. It is also found that the number densities of the fungi decrease exponentially with the energy expenditure of the corona discharge, and that damping coefficients of the fungi densities depend on the concentration of the hydroponic culture solutions. This suggests that the fungi are chiefly inactivated by electroporation.

  17. Cardiac magnetic resonance imaging in heart failure: where the alphabet begins!

    PubMed

    Aljizeeri, Ahmed; Sulaiman, Abdulbaset; Alhulaimi, Naji; Alsaileek, Ahmed; Al-Mallah, Mouaz H

    2017-07-01

    Cardiac Magnetic Resonance Imaging has become a cornerstone in the evaluation of heart failure. It provides a comprehensive evaluation by answering all the pertinent clinical questions across the full pathological spectrum of heart failure. Nowadays, CMR is considered the gold standard in evaluation of ventricular volumes, wall motion and systolic function. Through its unique ability of tissue characterization, it provides incremental diagnostic and prognostic information and thus has emerged as a comprehensive imaging modality in heart failure. This review outlines the role of main conventional CMR sequences in the evaluation of heart failure and their impact in the management and prognosis.

  18. Apollo 11 Mission images - Solar Corona (moon)

    NASA Image and Video Library

    1969-07-19

    AS11-42-6179 (19 July 1969) --- This photograph of the solar corona was taken from the Apollo 11 spacecraft during trans-lunar coast and prior to lunar orbit insertion. The moon is the dark disc between the spacecraft and the sun.

  19. High-cadence observations of CME initiation and plasma dynamics in the corona with TESIS on board CORONAS-Photon

    NASA Astrophysics Data System (ADS)

    Bogachev, Sergey; Kuzin, Sergey; Zhitnik, I. A.; Bugaenko, O. I.; Goncharov, A. L.; Ignatyev, A. P.; Krutov, V. V.; Lomkova, V. M.; Mitrofanov, A. V.; Nasonkina, T. P.; Oparin, S. N.; Petzov, A. A.; Shestov, S. V.; Slemzin, V. A.; Soloviev, V. A.; Suhodrev, N. K.; Shergina, T. A.

    The TESIS is an ensemble of space instruments designed in Lebedev Institute of Russian Academy of Sciences for spectroscopic and imaging investigation of the Sun in EUV and soft X-ray spectral range with high spatial, temporal and spectral resolution. From 2009 January, when TESIS was launched onboard the Coronas-Photon satellite, it provided about 200 000 new images and spectra of the Sun, obtained during one of the deepest solar minimum in last century. Because of the wide field of view (4 solar radii) and high sensitivity, TESIS provided high-quality data on the origin and dynamics of eruptive prominences and CMEs in the low and intermediate solar corona. TESIS is also the first EUV instrument which provided high-cadence observations of coronal bright points and solar spicules with temporal resolution of a few seconds. We present first results of TESIS observations and discuss them from a scientific point of view.

  20. Dielectric fluid directional spreading under the action of corona discharge

    NASA Astrophysics Data System (ADS)

    Zhou, Shangru; Liu, Jie; Hu, Qun; Jiang, Teng; Yang, Jinchu; Liu, Sheng; Zheng, Huai

    2018-01-01

    Liquid spreading is a very common nature phenomenon and of significant importance for a broad range of applications. In this study, a dielectric fluid directional spreading phenomenon is presented. Under the action of corona discharge, a dielectric fluid, here a typical silicone directionally spreads along conductive patterns on conductive/nonconductive substrates. Directional spreading behaviors of silicone were experimentally observed on different conductive patterns in detail. Spreading speeds were analyzed at different driving voltages, which induced the corona discharge. The presented phenomenon may be useful to inspire several techniques of manipulating liquid transportation and fabricating micropatterns.

  1. Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System.

    PubMed

    Barbero, Francesco; Russo, Lorenzo; Vitali, Michele; Piella, Jordi; Salvo, Ignacio; Borrajo, Mireya L; Busquets-Fité, Marti; Grandori, Rita; Bastús, Neus G; Casals, Eudald; Puntes, Victor

    2017-12-01

    The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Nanoflare Heating of Solar and Stellar Coronae

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2010-01-01

    A combination of observational and theoretical evidence suggests that much, and perhaps most, of the Sun's corona is heated by small unresolved bursts of energy called nanoflares. It seems likely that stellar coronae are heated in a similar fashion. Kanoflares are here taken to mean any impulsive heating that occurs within a magnetic flux strand. Many mechanisms have this property, including waves, but we prefer Parker's picture of tangled magnetic fields. The tangling is caused by turbulent convection at the stellar surface, and magnetic energy is released when the stresses reach a critical level. We suggest that the mechanism of energy release is the "secondary instability" of electric current sheets that are present at the boundaries between misaligned strands. I will discuss the collective evidence for solar and stellar nanoflares and hopefully present new results from the Solar Dynamics Observatory that was just launched.

  3. Dynamic development of the protein corona on silica nanoparticles: composition and role in toxicity

    NASA Astrophysics Data System (ADS)

    Mortensen, Ninell P.; Hurst, Gregory B.; Wang, Wei; Foster, Carmen M.; Nallathamby, Prakash D.; Retterer, Scott T.

    2013-06-01

    The formation and composition of the protein corona on silica (SiO2) nanoparticles (NP) with different surface chemistries was evaluated over time. Native SiO2, amine (-NH2) and carboxy (-COO-) modified NP were examined following incubation in mammalian growth media containing fetal bovine serum (FBS) for 1, 4, 24 and 48 hours. The protein corona transition from its early dynamic state to the later more stable corona was evaluated using mass spectrometry. The NP diameter was 22.4 +/- 2.2 nm measured by scanning transmission electron microscopy (STEM). Changes in hydrodynamic diameter and agglomeration kinetics were studied using dynamic light scattering (DLS). The initial surface chemistry of the NP played an important role in the development and final composition of the protein corona, impacting agglomeration kinetics and NP toxicity. Particle toxicity, indicated by changes in membrane integrity and mitochondrial activity, was measured by lactate dehydrogenase (LDH) release and tetrazolium reduction (MTT), respectively, in mouse alveolar macrophages (RAW264.7) and mouse lung epithelial cells (C10). SiO2-COO- NP had a slower agglomeration rate, formed smaller aggregates, and exhibited lower cytotoxicity compared to SiO2 and SiO2-NH2. Composition of the protein corona for each of the three NP was unique, indicating a strong dependence of corona development on NP surface chemistry. This work underscores the need to understand all aspects of NP toxicity, particularly the influence of agglomeration on effective dose and particle size. Furthermore, the interplay between materials and local biological environment is emphasized and highlights the need to conduct toxicity profiling under physiologically relevant conditions that provide an appropriate estimation of material modifications that occur during exposure in natural environments.The formation and composition of the protein corona on silica (SiO2) nanoparticles (NP) with different surface chemistries was evaluated

  4. The Protein Corona of Plant Virus Nanoparticles Influences their Dispersion Properties, Cellular Interactions, and In Vivo Fates.

    PubMed

    Pitek, Andrzej S; Wen, Amy M; Shukla, Sourabh; Steinmetz, Nicole F

    2016-04-06

    Biomolecules in bodily fluids such as plasma can adsorb to the surface of nanoparticles and influence their biological properties. This phenomenon, known as the protein corona, is well established in the field of synthetic nanotechnology but has not been described in the context of plant virus nanoparticles (VNPs). The interaction between VNPs derived from Tobacco mosaic virus (TMV) and plasma proteins is investigated, and it is found that the VNP protein corona is significantly less abundant compared to the corona of synthetic particles. The formed corona is dominated by complement proteins and immunoglobulins, the binding of which can be reduced by PEGylating the VNP surface. The impact of the VNP protein corona on molecular recognition and cell targeting in the context of cancer and thrombosis is investigated. A library of functionalized TMV rods with polyethylene glycol (PEG) and peptide ligands targeting integrins or fibrin(ogen) show different dispersion properties, cellular interactions, and in vivo fates depending on the properties of the protein corona, influencing target specificity, and non-specific scavenging by macrophages. Our results provide insight into the in vivo properties of VNPs and suggest that the protein corona effect should be considered during the development of efficacious, targeted VNP formulations. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Reconnection Processes in the Chromosphere and Corona

    NASA Astrophysics Data System (ADS)

    Shibata, Kazunari

    2012-07-01

    Magnetic reconnection is a fundamental key physical process in magnetized plasmas. Recent space solar observations revealed that magnetic reconnection is ubiquitous in the solar chromospheres and corona. Especially recent Hinode observations has found various types of tiny chromospheric jets, such as chromospheric anemone jets (Shibata et al. 2007), penumbral microjets (Katsukawa et al. 2007), light bridge jets from sunspot umbra (Shimizu et al. 2009), etc. It was also found that the corona is full of tiny X-ray jets (Cirtain et al. 2007). Often they are seen as helical spinning jets (Shimojo et al. 2007, Patsourakos et al. 2008, Pariat et al. 2009, Filippov et al. 2009, Kamio et al. 2010) with Alfvenic waves (Nishizuka et al. 2008, Liu et al. 2009) and there are increasing evidence of magnetic reconnection in these tiny jets. We can now say that as spatial resolution of observations become better and better, smaller and smaller flares and jets have been discovered, which implies that the magnetized solar atmosphere consist of fractal structure and dynamics, i.e., fractal reconnection. Bursty radio and hard X-ray emissions from flares also suggest the fractal reconnection and associated particle acceleration. Since magnetohydrodynamics (MHD) does not contain any characteristic length and time scale, it is natural that MHD structure, dynamics, and reconnection, tend to become fractal in ideal MHD plasmas with large magnetic Reynolds number such as in the solar atmosphere. We would discuss recent observations and theories related to fractal reconnection in the chromospheres and corona, and discuss possible implication to chromospheric and coronal heating.

  6. Observational capabilities of solar satellite "Coronas-Photon"

    NASA Astrophysics Data System (ADS)

    Kotov, Yu.

    Coronas-Photon mission is the third satellite of the Russian Coronas program on solar activity observation The main goal of the Coronas-Photon is the study of solar hard electromagnetic radiation in the wide energy range from UV up to high energy gamma-radiation sim 2000MeV Scientific payload for solar radiation observation consists of three type of instruments 1 monitors Natalya-2M Konus-RF RT-2 Penguin-M BRM Phoka Sphin-X Sokol for spectral and timing measurements of full solar disk radiation with timing in flare burst mode up to one msec Instruments Natalya-2M Konus-RF RT-2 will cover the wide energy range of hard X-rays and soft Gamma rays 15keV to 2000MeV and will together constitute the largest area detectors ever used for solar observations Detectors of gamma-ray monitors are based on structured inorganic scintillators with energy resolution sim 5 for nuclear gamma-line band to 35 for GeV-band PSD analysis is used for gamma neutron separation for solar neutron registration T 30MeV Penguin-M has capability to measure linear polarization of hard X-rays using azimuth are measured by Compton scattering asymmetry in case of polarization of an incident flux For X-ray and EUV monitors the scintillation phoswich detectors gas proportional counter CZT assembly and Filter-covered Si-diodes are used 2 Telescope-spectrometer TESIS for imaging solar spectroscopy in X-rays with angular resolution up to 1 in three spectral lines and RT-2 CZT assembly of CZT

  7. The Growth Potential of Corona Discharges from Aircraft Flying in Precipitation.

    DTIC Science & Technology

    1987-11-12

    required for corona onset. However, it turns out that the fields required to generate corona from ’ce and water particles of the anticipated size are...still significantly larger than those commonly encountered in a thundercloud. The exception here is the long water filament drawn out when water drop...trial and error had 300 cone-angle, with a tip of radius -20Im (measured with a travelling microscope). It was necessary to electrolyse the tip in

  8. Transfer of electrical space charge from corona between ground and thundercloud: Measurements and modeling

    NASA Technical Reports Server (NTRS)

    Soula, Serge

    1994-01-01

    The evolution of the vertical electric field profile deduced from simultaneous field measurements at several levels below a thundercloud shows the development of a space charge layer at least up to 600 m. The average charge density in the whole layer from 0 m to 600 m can reach about 1 nC m(exp -3). The ions are generated at the ground by corona effect and the production rate is evaluated with a new method from the comparison of field evolutions at the ground and at altitude after a lightning flash. The modeling of the relevant processes shows tht ground corona accounts for the observed field evolutions and that the aerosol particles concentration has a very large effect on the evolution of corona ions. However, with a realistic value for this concentration a large amount of ground corona ions reach the level of 600 m.

  9. Signatures of Lithospheric Flexure and Elevated Heat Flow in Stereo Topography at Coronae on Venus

    NASA Astrophysics Data System (ADS)

    O'Rourke, Joseph G.; Smrekar, Suzanne E.

    2018-02-01

    Signatures of lithospheric flexure were previously identified at a dozen or more large coronae on Venus. Thin plate models fit to topographic profiles return elastic parameters, allowing derivation of mechanical thickness and surface heat flows given an assumed yield strength envelope. However, the low resolution of altimetry data from the NASA Magellan mission has hindered studying the vast majority of coronae, particularly those less than a few hundred kilometers in diameter. Here we search for flexural signatures around 99 coronae over ˜20% of the surface in Magellan altimetry data and stereo-derived topography that was recently assembled from synthetic aperture radar images. We derive elastic thicknesses of ˜2 to 30 km (mostly ˜5 to 15 km) with Cartesian and axisymmetric models at 19 coronae. We discuss the implications of low values that were also noted in earlier gravity studies. Most mechanical thicknesses are estimated as <19 km, corresponding to thermal gradients >24 K km-1. Implied surface heat flows >95 mW m-2—twice the global average in many thermal evolution models—imply that coronae are major contributors to the total heat budget or Venus is cooling faster than expected. Binomial statistics show that "Type 2" coronae with incomplete fracture annuli are significantly less likely to host flexural signatures than "Type 1" coronae with largely complete annuli. Stress calculations predict extensional faulting where nearly all profiles intersect concentric fractures. We failed to identify systematic variations in flexural parameters based on type, geologic setting, or morphologic class. Obtaining quality, high-resolution topography from a planetwide survey is vital to verifying our conclusions.

  10. Microfluidic Examination of the "Hard" Biomolecular Corona Formed on Engineered Particles in Different Biological Milieu.

    PubMed

    Weiss, Alessia C G; Kempe, Kristian; Förster, Stephan; Caruso, Frank

    2018-04-18

    The formation of a biomolecular corona around engineered particles determines, in large part, their biological behavior in vitro and in vivo. To gain a fundamental understanding of how particle design and the biological milieu influence the formation of the "hard" biomolecular corona, we conduct a series of in vitro studies using microfluidics. This setup allows the generation of a dynamic incubation environment with precise control over the applied flow rate, stream orientation, and channel dimensions, thus allowing accurate control of the fluid flow and the shear applied to the proteins and particles. We used mesoporous silica particles, poly(2-methacryloyloxyethylphosphorylcholine) (PMPC)-coated silica hybrid particles, and PMPC replica particles (obtained by removal of the silica particle templates), representing high-, intermediate-, and low-fouling particle systems, respectively. The protein source used in the experiments was either human serum or human full blood. The effects of flow, particle surface properties, incubation medium, and incubation time on the formation of the biomolecular corona formation are examined. Our data show that protein adhesion on particles is enhanced after incubation in human blood compared to human serum and that dynamic incubation leads to a more complex corona. By varying the incubation time from 2 s to 15 min, we demonstrate that the "hard" biomolecular corona is kinetically subdivided into two phases comprising a tightly bound layer of proteins interacting directly with the particle surface and a loosely associated protein layer. Understanding the influence of particle design parameters and biological factors on the corona composition, as well as its dynamic assembly, may facilitate more accurate prediction of corona formation and therefore assist in the design of advanced drug delivery vehicles.

  11. Probing the modulated formation of gold nanoparticles-beta-lactoglobulin corona complexes and their applications.

    PubMed

    Yang, Jiang; Wang, Bo; You, Youngsang; Chang, Woo-Jin; Tang, Ke; Wang, Yi-Cheng; Zhang, Wenzhao; Ding, Feng; Gunasekaran, Sundaram

    2017-11-23

    Understanding the interactions between proteins and nanoparticles (NPs) along with the underlying structural and dynamic information is of utmost importance to exploit nanotechnology for biomedical applications. Upon adsorption onto a NP surface, proteins form a well-organized layer, termed the corona, that dictates the identity of the NP-protein complex and governs its biological pathways. Given its high biological relevance, in-depth molecular investigations and applications of NPs-protein corona complexes are still scarce, especially since different proteins form unique corona patterns, making identification of the biomolecular motifs at the interface critical. In this work, we provide molecular insights and structural characterizations of the bio-nano interface of a popular food-based protein, namely bovine beta-lactoglobulin (β-LG), with gold nanoparticles (AuNPs) and report on our investigations of the formation of corona complexes by combined molecular simulations and complementary experiments. Two major binding sites in β-LG were identified as being driven by citrate-mediated electrostatic interactions, while the associated binding kinetics and conformational changes in the secondary structures were also characterized. More importantly, the superior stability of the corona led us to further explore its biomedical applications, such as in the smartphone-based point-of-care biosensing of Escherichia coli (E. coli) and in the computed tomography (CT) of the gastrointestinal (GI) tract through oral administration to probe GI tolerance and functions. Considering their biocompatibility, edible nature, and efficient excretion through defecation, AuNPs-β-LG corona complexes have shown promising perspectives for future in vitro and in vivo clinical settings.

  12. Diagnostics of the solar corona from comparison between Faraday rotation measurements and magnetohydrodynamic simulations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Le Chat, G.; Cohen, O.; Kasper, J. C.

    Polarized natural radio sources passing behind the Sun experience Faraday rotation as a consequence of the electron density and magnetic field strength in coronal plasma. Since Faraday rotation is proportional to the product of the density and the component of the magnetic field along the line of sight of the observer, a model is required to interpret the observations and infer coronal structures. Faraday rotation observations have been compared with relatively ad hoc models of the corona. Here for the first time we compare these observations with magnetohydrodynamic (MHD) models of the solar corona driven by measurements of the photosphericmore » magnetic field. We use observations made with the NRAO Very Large Array of 34 polarized radio sources occulted by the solar corona between 5 and 14 solar radii. The measurements were made during 1997 May, and 2005 March and April. We compare the observed Faraday rotation values with values extracted from MHD steady-state simulations of the solar corona. We find that (1) using a synoptic map of the solar magnetic field just one Carrington rotation off produces poorer agreements, meaning that the outer corona changes in the course of one month, even in solar minimum; (2) global MHD models of the solar corona driven by photospheric magnetic field measurements are generally able to reproduce Faraday rotation observations; and (3) some sources show significant disagreement between the model and the observations, which appears to be a function of the proximity of the line of sight to the large-scale heliospheric current sheet.« less

  13. Ultra-fine-scale filamentary structures in the Outer Corona and the Solar Magnetic Field

    NASA Technical Reports Server (NTRS)

    Woo, Richard

    2006-01-01

    Filamentary structures following magnetic field lines pervade the Sun's atmosphere and offer us insight into the solar magnetic field. Radio propagation measurements have shown that the smallest filamentary structures in the solar corona are more than 2 orders of magnitude finer than those seen in solar imaging. Here we use radio Doppler measurements to characterize their transverse density gradient and determine their finest scale in the outer corona at 20-30 R(circled dot operator), where open magnetic fields prevail. Filamentary structures overly active regions have the steepest gradient and finest scale, while those overlying coronal holes have the shallowest gradient and least finest scale. Their organization by the underlying corona implies that these subresolution structures extend radially from the entire Sun, confirming that they trace the coronal magnetic field responsible for the radial expansion of the solar wind. That they are rooted all over the Sun elucidates the association between the magnetic field of the photosphere and that of the corona, as revealed by the similarity between the power spectra of the photospheric field and the coronal density fluctuations. This association along with the persistence of filamentary structures far from the Sun demonstrate that subresolution magnetic fields must play an important role not only in magnetic coupling of the photosphere and corona, but also in coronal heating and solar wind acceleration through the process of small-scale magnetic reconnection. They also explain why current widely used theoretical models that extrapolate photospheric magnetic fields into the corona do not predict the correct source of the solar wind.

  14. Current Sheets in the Corona and the Complexity of Slow Wind

    NASA Technical Reports Server (NTRS)

    Antiochos, Spiro

    2010-01-01

    The origin of the slow solar wind has long been one of the most important problems in solar/heliospheric physics. Two observational constraints make this problem especially challenging. First, the slow wind has the composition of the closed-field corona, unlike the fast wind that originates on open field lines. Second, the slow wind has substantial angular extent, of order 30 degrees, which is much larger than the widths observed for streamer stalks or the widths expected theoretically for a dynamic heliospheric current sheet. We propose that the slow wind originates from an intricate network of narrow (possibly singular) open-field corridors that emanate from the polar coronal hole regions. Using topological arguments, we show that these corridors must be ubiquitous in the solar corona. The total solar eclipse in August 2008, near the lowest point of cycle 23 affords an ideal opportunity to test this theory by using the ultra-high resolution Predictive Science's (PSI) eclipse model for the corona and wind. Analysis of the PSI eclipse model demonstrates that the extent and scales of the open-field corridors can account for both the angular width of the slow wind and its closed-field composition. We discuss the implications of our slow wind theory for the structure of the corona and heliosphere at solar minimum and describe further observational and theoretical tests.

  15. Energy-Dependent Ionization States of Shock-Accelerated Particles in the Solar Corona

    NASA Technical Reports Server (NTRS)

    Reames, Donald V.; Ng, C. K.; Tylka, A. J.

    2000-01-01

    We examine the range of possible energy dependence of the ionization states of ions that are shock-accelerated from the ambient plasma of the solar corona. If acceleration begins in a region of moderate density, sufficiently low in the corona, ions above about 0.1 MeV/amu approach an equilibrium charge state that depends primarily upon their speed and only weakly on the plasma temperature. We suggest that the large variations of the charge states with energy for ions such as Si and Fe observed in the 1997 November 6 event are consistent with stripping in moderately dense coronal. plasma during shock acceleration. In the large solar-particle events studied previously, acceleration occurs sufficiently high in the corona that even Fe ions up to 600 MeV/amu are not stripped of electrons.

  16. Negative DC corona discharge current characteristics in a flowing two-phase (air + suspended smoke particles) fluid

    NASA Astrophysics Data System (ADS)

    Berendt, Artur; Domaszka, Magdalena; Mizeraczyk, Jerzy

    2017-04-01

    The electrical characteristics of a steady-state negative DC corona discharge in a two-phase fluid (air with suspended cigarette smoke particles) flowing along a chamber with a needle-to-plate electrode arrangement were experimentally investigated. The two-phase flow was transverse in respect to the needle-to-plate axis. The velocity of the transverse two-phase flow was limited to 0.8 m/s, typical of the electrostatic precipitators. We found that three discharge current modes of the negative corona exist in the two-phase (air + smoke particles) fluid: the Trichel pulses mode, the "Trichel pulses superimposed on DC component" mode and the DC component mode, similarly as in the corona discharge in air (a single-phase fluid). The shape of Trichel pulses in the air + suspended particles fluid is similar to that in air. However, the Trichel pulse amplitudes are higher than those in "pure" air while their repetition frequency is lower. As a net consequence of that the averaged corona discharge current in the two-phase fluid is lower than in "pure" air. It was also found that the average discharge current decreases with increasing suspended particle concentration. The calculations showed that the dependence of the average negative corona current (which is a macroscopic corona discharge parameter) on the particle concentration can be explained by the particle-concentration dependencies of the electric charge of Trichel pulse and the repetition frequency of Trichel pulses, both giving a microscopic insight into the electrical phenomena in the negative corona discharge. Our investigations showed also that the average corona discharge current in the two-phase fluid is almost unaffected by the transverse fluid flow up to a velocity of 0.8 m/s. Contribution to the topical issue "The 15th International Symposium on High Pressure Low Temperature Plasma Chemistry (HAKONE XV)", edited by Nicolas Gherardi and Tomáš Hoder

  17. A numerical model of acoustic wave caused by a single positive corona source

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Li, Zhen; He, Jinliang

    2017-10-01

    Audible noise accompanies corona discharge, which is one of the most important electromagnetic environment issues of high voltage transmission lines. Most of the studies on the audible noise generated by corona discharge focused on statistical analysis of the experimental results and a series of empirical formulas were derived to predict the audible noise. However, few of them interpreted the generating mechanism of the audible noise. Sound wave in the air is actually the fluctuation of the air, which lead to the hypothesis that the sound wave is generated by the interaction of the charged particles and the air molecules in the discharge progress. To validate this hypothesis, experiments were carried out in this paper to study the relationship between the audible noise and the corona current, including the correlation both in time domain and in frequency domain. Based on the experimental results, the fluid equations of the particles in the air were introduced to study the interactions among the electrons, ions, and neutral molecules in the discharge, and a numerical model for the amplitude of corona acoustic emission was developed and validated.

  18. Applicability of Generalized Peek's Law to Scaling of Corona Onset Voltages in Electropositive Gases

    NASA Astrophysics Data System (ADS)

    Li, Yan-Ming

    2008-10-01

    We have developed the steady state positive corona model with the ionization zone physics in the point-plane configuration. The geometry is axisymmetric, consisting of a pointed anode of small tip radius and a planar cathode. The model solves the Poisson equation, drift dominated electron and the positive ion transport equations with the nonlinear Townsend ionization source terms, to give the complete electric field, electron and positive ion density distributions. The corona plasma properties can be determined as function of discharge current, ranging from the pico-ampere up to a milli-ampere. The calculated voltage-current characteristics obeyed the Townsend equation, agreeing with the general experimental observations. The model is applied to different electropositive gases, argon, xenon, nitrogen and mercury. Corona onset potentials are determined based on the discharge voltages at very low currents. Extensive parametric study for argon positive corona with varying anode tip radius, gap distance and gas pressure has been completed. All the simulated corona onset voltages are very well described by the generalized Peek's Law [1]. At sufficiently high current in the range of 0.1 mA, discharge filament is formed near the anode tip. [1] Peek F. W., Dielectric Phenomena in High Voltage Engineering, McGraw Hill, New York (1929).

  19. Processing method of images obtained during the TESIS/CORONAS-PHOTON experiment

    NASA Astrophysics Data System (ADS)

    Kuzin, S. V.; Shestov, S. V.; Bogachev, S. A.; Pertsov, A. A.; Ulyanov, A. S.; Reva, A. A.

    2011-04-01

    In January 2009, the CORONAS-PHOTON spacecraft was successfully launched. It includes a set of telescopes and spectroheliometers—TESIS—designed to image the solar corona in soft X-ray and EUV spectral ranges. Due to features of the reading system, to obtain physical information from these images, it is necessary to preprocess them, i.e., to remove the background, correct the white field, level, and clean. The paper discusses the algorithms and software developed and used for the preprocessing of images.

  20. An Experimental Study of Incremental Surface Loading of an Elastic Plate: Application to Volcano Tectonics

    NASA Technical Reports Server (NTRS)

    Williams, K. K.; Zuber, M. T.

    1995-01-01

    Models of surface fractures due to volcanic loading an elastic plate are commonly used to constrain thickness of planetary lithospheres, but discrepancies exist in predictions of the style of initial failure and in the nature of subsequent fracture evolution. In this study, we perform an experiment to determine the mode of initial failure due to the incremental addition of a conical load to the surface of an elastic plate and compare the location of initial failure with that predicted by elastic theory. In all experiments, the mode of initial failure was tension cracking at the surface of the plate, with cracks oriented circumferential to the load. The cracks nucleated at a distance from load center that corresponds the maximum radial stress predicted by analytical solutions, so a tensile failure criterion is appropriate for predictions of initial failure. With continued loading of the plate, migration of tensional cracks was observed. In the same azimuthal direction as the initial crack, subsequent cracks formed at a smaller radial distance than the initial crack. When forming in a different azimuthal direction, the subsequent cracks formed at a distance greater than the radial distance of the initial crack. The observed fracture pattern may explain the distribution of extensional structures in annular bands around many large scale, circular volcanic features.

  1. Visualization of corona discharge induced by UV (248 nm) pulses of a KrF excimer laser

    NASA Astrophysics Data System (ADS)

    Mizeraczyk, Jerzy; Ohkubo, Toshikazu; Kanazawa, Seiji; Nomoto, Yukiharu; Kawasaki, Toshiyuki; Kocik, Marek

    2000-11-01

    A KrF excimer laser (248 nm) was used to induce DC corona discharge streamers in air between the electrodes of a needle-to-plane geometry. The UV laser beam pulses were transformed into the form of a laser sheet (1.5 mm thick and 20 mm-wide) that was positioned along the axis directed from the needle electrode to the plane electrode. The laser pulses were time-synchronized with the exposure of an ICCD camera that record images of the corona streamers induced by the laser sheet. The laser pulse energy flux (75 MW/cm2) crossing the gap was high enough to induce corona streamers with a reliability of 100% even at relatively low operating voltages (e.g., 15 kV) at which self-sustained streamers could not occur. Due to the full synchronization of the corona streamer onset, induced by the laser pulse and the exposure of the ICCD camera, 2-D visualization of the corona streamer evolution with a time resolution of 10 ns was possible. The recorded images made possible determining such features of the corona discharge streamer as its velocity (2.5 105 m/s) and the diameters of the leader channel (200 micrometers ) and the leader streamers (100 micrometers ).

  2. 48 CFR 3452.232-71 - Incremental funding.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Incremental funding. 3452... 3452.232-71 Incremental funding. As prescribed in 3452.771, insert the following provision in solicitations: Incremental Funding (AUG 1987) (a) Sufficient funds are not presently available to cover the...

  3. Geophysical models for the formation and evolution of coronae on Venus

    NASA Technical Reports Server (NTRS)

    Janes, Daniel M.; Squyres, Steven W.; Bindschadler, Duane L.; Baer, Gidon; Schubert, Gerald; Sharpton, Virgil L.; Stofan, Ellen R.

    1992-01-01

    The proposition that Venusian coronae form over sites of mantle upwelling and are modified by subsequent gravitational relaxation is examined using two geophysical models to determine whether and under what conditions these mechanisms can produce the topography and tectonics exhibited by coronae in the Magellan altimetry data and radar images. It is shown that mantle diapirism can produce the domical topography of novae, which may be coronae in the earliest stage of formation. The model stresses induced at the surface by a mantle diapir imply the formation of radially oriented extensional fracturing as observed in novae. The novae dimensions indicate that the diapirs responsible for them are smaller than about 100 km in radius and that the elastic lithosphere is less than 32 km thick. A flattened diapir at the top of the mantle is modeled and shown to result in plateaulike uplift. The volume of the flattened model diapir is similar to that of the spherical diapirs derived for novae.

  4. The Mechanism for Energy Buildup in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Antiochos, Spiro; Knizhnik, Kalman; DeVore, Richard

    2017-10-01

    Magnetic reconnection and helicity conservation are two of the most important basic processes determining the structure and dynamics of laboratory and space plasmas. The most energetic dynamics in the solar system are the giant CMEs/flares that produce the most dangerous space weather at Earth, yet may also have been essential for the origin of life. The origin of these explosions is that the lowest-lying magnetic flux in the Sun's corona undergoes the continual buildup of stress and free energy that can be released only through explosive ejection. We perform MHD simulations of a coronal volume driven by quasi-random boundary flows designed to model the processes by which the solar interior drives the corona. Our simulations are uniquely accurate in preserving magnetic helicity. We show that even though small-scale stress is injected randomly throughout the corona, the net result of magnetic reconnection is a coherent stressing of the lowest-lying field lines. This highly counter-intuitive result - magnetic stress builds up locally rather than spreading out to a minimum energy state - is the fundamental mechanism responsible for the Sun's magnetic explosions. It is likely to be a mechanism that is ubiquitous throughout laboratory and space plasmas. This work was supported by the NASA LWS and SR Programs.

  5. 14 CFR § 1260.53 - Incremental funding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Incremental funding. § 1260.53 Section § 1260.53 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Special Conditions § 1260.53 Incremental funding. Incremental Funding October 2000 (a...

  6. Outflow structure of the quiet sun corona probed by spacecraft radio scintillations in strong scattering

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Imamura, Takeshi; Ando, Hiroki; Toda, Tomoaki

    Radio scintillation observations have been unable to probe flow speeds in the low corona where the scattering of radio waves is exceedingly strong. Here we estimate outflow speeds continuously from the vicinity of the Sun to the outer corona (heliocentric distances of 1.5-20.5 solar radii) by applying the strong scattering theory to radio scintillations for the first time, using the Akatsuki spacecraft as the radio source. Small, nonzero outflow speeds were observed over a wide latitudinal range in the quiet-Sun low corona, suggesting that the supply of plasma from closed loops to the solar wind occurs over an extended area.more » The existence of power-law density fluctuations down to the scale of 100 m was suggested, which is indicative of well-developed turbulence which can play a key role in heating the corona. At higher altitudes, a rapid acceleration typical of radial open fields is observed, and the temperatures derived from the speed profile show a distinct maximum in the outer corona. This study opened up a possibility of observing detailed flow structures near the Sun from a vast amount of existing interplanetary scintillation data.« less

  7. Imaging the Top of the Solar Corona and the Young Solar Wind

    NASA Astrophysics Data System (ADS)

    DeForest, C. E.; Matthaeus, W. H.; Viall, N. M.; Cranmer, S. R.

    2016-12-01

    We present the first direct visual evidence of the quasi-stationary breakup of solar coronal structure and the rise of turbulence in the young solar wind, directly in the future flight path of Solar Probe. Although the corona and, more recently, the solar wind have both been observed directly with Thomson scattered light, the transition from the corona to the solar wind has remained a mystery. The corona itself is highly structured by the magnetic field and the outflowing solar wind, giving rise to radial "striae" - which comprise the familiar streamers, pseudostreamers, and rays. These striae are not visible in wide-field heliospheric images, nor are they clearly delineated with in-situ measurements of the solar wind. Using careful photometric analysis of the images from STEREO/HI-1, we have, for the first time, directly observed the breakup of radial coronal structure and the rise of nearly-isotropic turbulent structure in the outflowing slow solar wind plasma between 10° (40 Rs) and 20° (80 Rs) from the Sun. These observations are important not only for their direct science value, but for predicting and understanding the conditions expected near SPP as it flies through - and beyond - this final frontier of the heliosphere, the outer limits of the solar corona.

  8. Protein Corona Modulates Uptake and Toxicity of Nanoceria via Clathrin-Mediated Endocytosis.

    PubMed

    Mazzolini, Julie; Weber, Ralf J M; Chen, Hsueh-Shih; Khan, Abdullah; Guggenheim, Emily; Shaw, Robert K; Chipman, James K; Viant, Mark R; Rappoport, Joshua Z

    2016-08-01

    Particles present in diesel exhaust have been proposed as a significant contributor to the development of acute and chronic lung diseases, including respiratory infection and allergic asthma. Nanoceria (CeO2 nanoparticles) are used to increase fuel efficiency in internal combustion engines, are present in exhaust fumes, and could affect cells of the airway. Components from the environment such as biologically derived proteins, carbohydrates, and lipids can form a dynamic layer, commonly referred to as the "protein corona" which alters cellular nanoparticle interactions and internalization. Using confocal reflectance microscopy, we quantified nanoceria uptake by lung-derived cells in the presence and absence of a serum-derived protein corona. Employing mass spectrometry, we identified components of the protein corona, and demonstrated that the interaction between transferrin in the protein corona and the transferrin receptor is involved in mediating the cellular entry of nanoceria via clathrin-mediated endocytosis. Furthermore, under these conditions nanoceria does not affect cell growth, viability, or metabolism, even at high concentration. Alternatively, despite the antioxidant capacity of nanoceria, in serum-free conditions these nanoparticles induce plasma membrane disruption and cause changes in cellular metabolism. Thus, our results identify a specific receptor-mediated mechanism for nanoceria entry, and provide significant insight into the potential for nanoparticle-dependent toxicity. © 2016 Marine Biological Laboratory.

  9. Measurement of OH Radicals in Pulsed Corona and Pulsed Dielectric Barrier Discharge

    NASA Astrophysics Data System (ADS)

    Ono, Ryo; Oda, Tetsuji

    OH radicals are measured in a pulsed corona or a pulsed dielectric barrier discharge (DBD) using laserinduced fluorescence (LIF) method. The pulsed discharges occur in nitrogen-oxygen mixture with 2.4% water vapor at atmospheric pressure. The pulse width is 100ns and the peak voltage is 35kV. The electrode configuration is a needle to plate electrode with 16-mm gap for corona discharge, and with 5-mm gap for DBD where the barrier is 2mm thick glass plate. It is shown that OH density is approximately proportional to the energy consumed by the discharge. The OH density per the discharge energy is about 2-4×1014cm-3/mJ for both discharges in H2O(2.4%)/N2 mixture. It is shown that OH density increases with oxygen content in DBD, whereas OH density reaches a maximum at 3% oxygen content in corona discharge. The existence of oxygen accelerates OH decay rate in both discharges. A trace amount of trichloroethylene (TCE) is added to the ambient gas. It is shown that the addition of 100ppm TCE to corona discharge reduces discharge current by about 50%. That leads to decrease of OH production.

  10. Spectroscopic Identification of Isomeric Trimethylbenzyl Radicals Generated in Corona Discharge of Tetramethylbenzene

    NASA Astrophysics Data System (ADS)

    Yoon, Young Wook; Lee, Sang Kuk; Lee, Gi Woo

    2011-06-01

    The visible vibronic emission spectra were recorded from the corona discharge of precursor tetramethylbenzene with a large amount of inert carrier gas helium using a pinhole-type glass nozzle coupled with corona excited supersonic expansion (CESE) well developed in this laboratory. The spectra showed a series of vibronic bands in the D_1 → D_0 electronic transition of jet-cooled benzyl-type radicals formed from the precursor in a corona excitation. The analysis confirmed that two isomeric radicals, 2,3,4- and 2,3,6-trimethylbenzyl radicals and three isomeric radicals, 3,4,5-, 2,3,5- and 2,4,6-trimethylbenzyl radicals were produced, respectively, from 1,2,3,4- and 1,2,3,5-tetramethylbenzenes as a result of removal of a hydrogen atom from the methyl group at different substitution position. For each isomeric trimethylbenzyl radical generated in the corona discharge of precursor, the electronic transition and a few vibrational mode frequencies were determined in the ground electronic state by comparing with those from both ab initio calculations and the known vibrational data of the precursor. The substitution effect that states the shift of electronic transition depends on the nature, the number, and the position of substituents on the ring has been qualitatively proved for the case of benzyl-type radicals.

  11. Effects of heavy ions on electron temperatures in the solar corona and solar wind

    NASA Technical Reports Server (NTRS)

    Nakada, M. P.

    1972-01-01

    The effects of the reduction in the thermal conductivity due to heavy ions on electron temperatures in the solar corona and solar wind are examined. Large enhancements of heavy ions in the corona appear to be necessary to give appreciable changes in the thermal gradient of the electrons.

  12. The Structure and Dynamics of the Solar Corona and Inner Heliosphere

    NASA Technical Reports Server (NTRS)

    Mikic, Zoran; Grebowsky, J. (Technical Monitor)

    2002-01-01

    This report covers technical progress during the fourth quarter of the second year of NASA Sun-Earth Connections Theory Program (SECTP) contract "The Structure and Dynamics of the Solar Corona and Inner Heliosphere," NAS5-99188, between NASA and Science Applications International Corporation (SAIC), and covers the period May 16, 2001 to August 15, 2001. Under this contract SAIC and the University of California, Irvine (UCI) have conducted research into theoretical modeling of active regions, the solar corona, and the inner heliosphere, using the MHD (magnetohydrodynamic) model.

  13. Simulation of Needle-Type Corona Electrodes by the Finite Element Method

    NASA Astrophysics Data System (ADS)

    Yang, Shiyou; José Márcio, Machado; Nancy Mieko, Abe; Angelo, Passaro

    2007-12-01

    This paper describes a software tool, called LEVSOFT, suitable for the electric field simulations of corona electrodes by the Finite Element Method (FEM). Special attention was paid to the user friendly construction of geometries with corners and sharp points, and to the fast generation of highly refined triangular meshes and field maps. The execution of self-adaptive meshes was also implemented. These customized features make the code attractive for the simulation of needle-type corona electrodes. Some case examples involving needle type electrodes are presented.

  14. Influence of humidity on the characteristics of negative corona discharge in air

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xu, Pengfei, E-mail: xpftsh@126.com; Zhang, Bo, E-mail: shizbcn@mail.tsinghua.edu.cn; He, Jinliang, E-mail: hejl@tsinghua.edu.cn

    Detailed negative corona discharge characteristics, such as the pulse amplitude, repetition frequency, average corona current, rise time, and half-wave time, are systematically studied under various air humidities with a single artificial defect electrode. The experimental result reveals that the pulse amplitude increases with the increase of air humidity; meanwhile, the repetition frequency deceases as the air humidity increases. Empirical formulae are first established for the pulse amplitude and repetition frequency with the humidity factor taken into consideration. The effective ionization integral is calculated and a positive correlation is found between the integral and the pulse amplitude. Furthermore, a simplified negative-ionmore » cloud model is built up to investigate the mechanism of the humidity's influence on negative corona discharge. Based on the theoretical analyses, the correlation between pulse amplitude, repetition frequency, and air humidity is well explained.« less

  15. Laboratory study of microphysical and scattering properties of corona-producing cirrus clouds.

    PubMed

    Järvinen, E; Vochezer, P; Möhler, O; Schnaiter, M

    2014-11-01

    Corona-producing cirrus clouds were generated and measured under chamber conditions at the AIDA cloud chamber in Karlsruhe. We were able to measure the scattering properties as well as microphysical properties of these clouds under well-defined laboratory conditions in contrast with previous studies of corona-producing clouds, where the measurements were conducted by means of lidar and in situ aircraft measurements. Our results are in agreement with those of previous studies, confirming that corona-producing cirrus clouds consist of a narrow distribution of small (median Dp=19-32  μm) and compact ice crystals. We showed that the ice crystals in these clouds are most likely formed in homogeneous freezing processes. As a result of the homogeneous freezing process, the ice crystals grow uniformly in size; furthermore, the majority of the ice crystals have rough surface features.

  16. Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor β1 Activity in Triggering Lung Fibrosis.

    PubMed

    Wang, Zhenzhen; Wang, Chunming; Liu, Shang; He, Wei; Wang, Lintao; Gan, JingJing; Huang, Zhen; Wang, Zhenheng; Wei, Haoyang; Zhang, Junfeng; Dong, Lei

    2017-02-28

    A corona is a layer of macromolecules formed on a nanoparticle surface in vivo. It can substantially change the biological identity of nanomaterials and possibly trigger adverse responses from the body tissues. Dissecting the role of the corona in the development of a particular disease may provide profound insights for understanding toxicity of nanomaterials in general. In our present study, we explored the capability of different silica nanoparticles (SiNPs) to induce silicosis in the mouse lung and analyzed the composition of coronas formed on these particles. We found that SiNPs of certain size and surface chemistry could specifically recruit transforming growth factor β1 (TGF-β1) into their corona, which subsequently induces the development of lung fibrosis. Once embedded into the corona on SiNPs, TGF-β1 was remarkably more stable than in its free form, and its fibrosis-triggering activity was significantly prolonged. Our study meaningfully demonstrates that a specific corona component on a certain nanoparticle could initiate a particular pathogenic process in a clinically relevant disease model. Our findings may shed light on the understanding of molecular mechanisms of human health risks correlated with exposure to small-scale substances.

  17. Core/corona modeling of diode-imploded annular loads

    NASA Astrophysics Data System (ADS)

    Terry, R. E.; Guillory, J. U.

    1980-11-01

    The effects of a tenuous exterior plasma corona with anomalous resistivity on the compression and heating of a hollow, collisional aluminum z-pinch plasma are predicted by a one-dimensional code. As the interior ("core") plasma is imploded by its axial current, the energy exchange between core and corona determines the current partition. Under the conditions of rapid core heating and compression, the increase in coronal current provides a trade-off between radial acceleration and compression, which reduces the implosion forces and softens the pitch. Combined with a heuristic account of energy and momentum transport in the strongly coupled core plasma and an approximate radiative loss calculation including Al line, recombination and Bremsstrahlung emission, the current model can provide a reasonably accurate description of imploding annular plasma loads that remain azimuthally symmetric. The implications for optimization of generator load coupling are examined.

  18. 14 CFR § 1274.918 - Incremental funding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Incremental funding. § 1274.918 Section Â... WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.918 Incremental funding. Incremental Funding July 2002 (a) Of the award amount indicated on the cover page of this Agreement, only the...

  19. Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition.

    PubMed

    Raesch, Simon Sebastian; Tenzer, Stefan; Storck, Wiebke; Rurainski, Alexander; Selzer, Dominik; Ruge, Christian Arnold; Perez-Gil, Jesus; Schaefer, Ulrich Friedrich; Lehr, Claus-Michael

    2015-12-22

    Pulmonary surfactant (PS) constitutes the first line of host defense in the deep lung. Because of its high content of phospholipids and surfactant specific proteins, the interaction of inhaled nanoparticles (NPs) with the pulmonary surfactant layer is likely to form a corona that is different to the one formed in plasma. Here we present a detailed lipidomic and proteomic analysis of NP corona formation using native porcine surfactant as a model. We analyzed the adsorbed biomolecules in the corona of three NP with different surface properties (PEG-, PLGA-, and Lipid-NP) after incubation with native porcine surfactant. Using label-free shotgun analysis for protein and LC-MS for lipid analysis, we quantitatively determined the corona composition. Our results show a conserved lipid composition in the coronas of all investigated NPs regardless of their surface properties, with only hydrophilic PEG-NPs adsorbing fewer lipids in total. In contrast, the analyzed NP displayed a marked difference in the protein corona, consisting of up to 417 different proteins. Among the proteins showing significant differences between the NP coronas, there was a striking prevalence of molecules with a notoriously high lipid and surface binding, such as, e.g., SP-A, SP-D, DMBT1. Our data indicate that the selective adsorption of proteins mediates the relatively similar lipid pattern in the coronas of different NPs. On the basis of our lipidomic and proteomic analysis, we provide a detailed set of quantitative data on the composition of the surfactant corona formed upon NP inhalation, which is unique and markedly different to the plasma corona.

  20. Characterization of the bionano interface and mapping extrinsic interactions of the corona of nanomaterials

    NASA Astrophysics Data System (ADS)

    O'Connell, D. J.; Bombelli, F. Baldelli; Pitek, A. S.; Monopoli, M. P.; Cahill, D. J.; Dawson, K. A.

    2015-09-01

    Nanoparticles in physiological environments are known to selectively adsorb proteins and other biomolecules forming a tightly bound biomolecular `corona' on their surface. Where the exchange times of the proteins are sufficiently long, it is believed that the protein corona constitutes the particle identity in biological milieu. Here we show that proteins in the corona retain their functional characteristics and can specifically bind to cognate proteins on arrays of thousands of immobilised human proteins. The biological identity of the nanomaterial is seen to be specific to the blood plasma concentration in which they are exposed. We show that the resulting in situ nanoparticle interactome is dependent on the protein concentration in plasma, with the emergence of a small number of dominant protein-protein interactions. These interactions are those driven by proteins that are adsorbed onto the particle surface and whose binding epitopes are subsequently expressed or presented suitably on the particle surface. We suggest that, since specific tailored protein arrays for target systems and organs can be designed, their use may be an important element in an overall study of the biomolecular corona.Nanoparticles in physiological environments are known to selectively adsorb proteins and other biomolecules forming a tightly bound biomolecular `corona' on their surface. Where the exchange times of the proteins are sufficiently long, it is believed that the protein corona constitutes the particle identity in biological milieu. Here we show that proteins in the corona retain their functional characteristics and can specifically bind to cognate proteins on arrays of thousands of immobilised human proteins. The biological identity of the nanomaterial is seen to be specific to the blood plasma concentration in which they are exposed. We show that the resulting in situ nanoparticle interactome is dependent on the protein concentration in plasma, with the emergence of a small

  1. THE STRUCTURE AND SPECTRAL FEATURES OF A THIN DISK AND EVAPORATION-FED CORONA IN HIGH-LUMINOSITY ACTIVE GALACTIC NUCLEI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, J. Y.; Liu, B. F.; Qiao, E. L.

    We investigate the accretion process in high-luminosity active galactic nuclei (HLAGNs) in the scenario of the disk evaporation model. Based on this model, the thin disk can extend down to the innermost stable circular orbit (ISCO) at accretion rates higher than 0.02 M-dot{sub Edd} while the corona is weak since part of the coronal gas is cooled by strong inverse Compton scattering of the disk photons. This implies that the corona cannot produce as strong X-ray radiation as observed in HLAGNs with large Eddington ratio. In addition to the viscous heating, other heating to the corona is necessary to interpretmore » HLAGN. In this paper, we assume that a part of accretion energy released in the disk is transported into the corona, heating up the electrons, and is thereby radiated away. For the first time, we compute the corona structure with additional heating, fully taking into account the mass supply to the corona, and find that the corona could indeed survive at higher accretion rates and that its radiation power increases. The spectra composed of bremsstrahlung and Compton radiation are also calculated. Our calculations show that the Compton-dominated spectrum becomes harder with the increase of energy fraction (f) liberating in the corona, and the photon index for hard X-ray (2-10 keV) is 2.2 < {Gamma} < 2.7. We discuss possible heating mechanisms for the corona. Combining the energy fraction transported to the corona with the accretion rate by magnetic heating, we find that the hard X-ray spectrum becomes steeper at a larger accretion rate and the bolometric correction factor (L{sub bol}/L{sub 2-10keV}) increases with increasing accretion rate for f < 8/35, which is roughly consistent with the observational results.« less

  2. On a decrease of high-latitude corona temperature of the Sun in the last 50 years

    NASA Astrophysics Data System (ADS)

    Makarov, V. I.; Tlatov, A. G.

    2002-03-01

    The ground-based observations of the green Fe XIV 5303 Å and red Fe X 6374 Å corona forbidden lines obtained at the Kislovodsk Solar Station since 1952 are used to determine the temperature variations of the solar corona. The observations of the solar corona at the Arosa, Pic du Midi, Kislovodsk, Norikura, Kanzelhöhe, Wendelstein and Lomnický Stit have been used to receive the Kislovodsk series of the green K I5303 and red K I6374 corona intensities for 1947-2000. Comparison of the K I5303 with the Wolf numbers W(t) shows high correlation factor 0.91. The mean monthly corona intensity has been calculated in the sunspot (0° - 45°) and at the high-latitude (45° - 90°) zones. We found a decrease of the K I5303 in 1.5 times at the high-latitudes in this period. It was shown that the ratio K I6374/K I5303 increased more than two times. We have found a decrease of temperature in polar zones of the Sun of order 0.1×106 during the last 50 years. It is supposed that a decrease of polar corona temperature connected with an increase of magnetic flux from high-latitude regions of the Sun during the last 120 years.

  3. Observaciones de la corona solar interior con un coronógrafo de espejo

    NASA Astrophysics Data System (ADS)

    Stenborg, G.; Schwenn, R.; Francile, C.; Rovira, M.

    El plasma de la corona solar es un buen indicador de las líneas de fuerza del campo magnético. Por lo tanto, el análisis de estructuras coronales cuasiestacionarias en la corona da importante información sobre el campo magnético y la actividad asociada. Se trata de poner límites a los modelos teóricos existentes mediante el estudio de distintas estructuras en la corona interior. En agosto de 1997 comenzó a operar el coronógrafo solar (MICA) en El Leoncito como parte del Observatorio Solar Alemán-Argentino. Desde su instalación obtiene imágenes de la corona solar (1.05 a 2.0 radios solares) en 2 líneas espectrales correspondientes a la emisión de Fe XIV y Fe X. El instrumento puede obtener imágenes cada minuto por lo que es ideal para estudiar procesos rápidos. Presentamos observaciones recientes que muestran la capacidad del coronógrafo así como la evolución de algunos eventos dinámicos observados por MICA.

  4. The X-Ray Polarization of the Accretion Disk Coronae of Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Beheshtipour, Banafsheh; Krawczynski, Henric; Malzac, Julien

    2017-11-01

    Hard X-rays observed in Active Galactic Nuclei (AGNs) are thought to originate from the Comptonization of the optical/UV accretion disk photons in a hot corona. Polarization studies of these photons can help to constrain the corona geometry and the plasma properties. We have developed a ray-tracing code that simulates the Comptonization of accretion disk photons in coronae of arbitrary shapes, and use it here to study the polarization of the X-ray emission from wedge and spherical coronae. We study the predicted polarization signatures for the fully relativistic and various approximate treatments of the elemental Compton scattering processes. We furthermore use the code to evaluate the impact of nonthermal electrons and cyclo-synchrotron photons on the polarization properties. Finally, we model the NuSTAR observations of the Seyfert I galaxy Mrk 335 and predict the associated polarization signal. Our studies show that X-ray polarimetry missions such as NASA’s Imaging X-ray Polarimetry Explorer and the X-ray Imaging Polarimetry Explorer proposed to ESA will provide valuable new information about the physical properties of the plasma close to the event horizon of AGN black holes.

  5. Corona discharge induced snow formation in a cloud chamber.

    PubMed

    Ju, Jingjing; Wang, Tie-Jun; Li, Ruxin; Du, Shengzhe; Sun, Haiyi; Liu, Yonghong; Tian, Ye; Bai, Yafeng; Liu, Yaoxiang; Chen, Na; Wang, Jingwei; Wang, Cheng; Liu, Jiansheng; Chin, S L; Xu, Zhizhan

    2017-09-18

    Artificial rainmaking is in strong demand especially in arid regions. Traditional methods of seeding various Cloud Condensation Nuclei (CCN) into the clouds are costly and not environment friendly. Possible solutions based on ionization were proposed more than 100 years ago but there is still a lack of convincing verification or evidence. In this report, we demonstrated for the first time the condensation and precipitation (or snowfall) induced by a corona discharge inside a cloud chamber. Ionic wind was found to have played a more significant role than ions as extra CCN. In comparison with another newly emerging femtosecond laser filamentation ionization method, the snow precipitation induced by the corona discharge has about 4 orders of magnitude higher wall-plug efficiency under similar conditions.

  6. A Covert Disruptive Technology: Test and Development of the Corona Satellite

    NASA Technical Reports Server (NTRS)

    Peebles, Curtis

    2008-01-01

    The launching by the Soviet Union of the Sputnik satellite in 19457 was an impetuous to the United States. The Intercontinental ballistic Missile (ICBM) that launched the Earth's first satellite, could have been armed with a nuclear warhead, that could destroy an American city. The primary intelligence requirement that the US had was to determine the actual size of the Soviet missile program. To this end, a covert, high-risk photoreconnaissance satellite was developed. The code name of this program was "Corona." This article describes the trials and eventual successes of the Corona program.

  7. SWAP OBSERVATIONS OF THE LONG-TERM, LARGE-SCALE EVOLUTION OF THE EXTREME-ULTRAVIOLET SOLAR CORONA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Seaton, Daniel B.; De Groof, Anik; Berghmans, David

    The Sun Watcher with Active Pixels and Image Processing (SWAP) EUV solar telescope on board the Project for On-Board Autonomy 2 spacecraft has been regularly observing the solar corona in a bandpass near 17.4 nm since 2010 February. With a field of view of 54 × 54 arcmin, SWAP provides the widest-field images of the EUV corona available from the perspective of the Earth. By carefully processing and combining multiple SWAP images, it is possible to produce low-noise composites that reveal the structure of the EUV corona to relatively large heights. A particularly important step in this processing was tomore » remove instrumental stray light from the images by determining and deconvolving SWAP's point-spread function from the observations. In this paper, we use the resulting images to conduct the first-ever study of the evolution of the large-scale structure of the corona observed in the EUV over a three year period that includes the complete rise phase of solar cycle 24. Of particular note is the persistence over many solar rotations of bright, diffuse features composed of open magnetic fields that overlie polar crown filaments and extend to large heights above the solar surface. These features appear to be related to coronal fans, which have previously been observed in white-light coronagraph images and, at low heights, in the EUV. We also discuss the evolution of the corona at different heights above the solar surface and the evolution of the corona over the course of the solar cycle by hemisphere.« less

  8. Predicting the Structure of the Solar Corona for the Total Solar Eclipse of March 29,2006

    NASA Technical Reports Server (NTRS)

    Mikic, Z.; Linker, J. a.; Lionello, R.; Riley, P.; TItov, V.

    2007-01-01

    We describe the use of a three-dimensional MHD model to predict the s tructure of the corona prior to the total solar eclipse of March 29, 2006. The calculation uses the observed photospheric radial magnetic f ield as a boundary condition. We use a new version of our model that has an improved description of energy transport in the corona. The mo del allows us to predict the emission of X-ray and EUV radiation in t he corona. We compare the predicted polarization brightness in the co rona with four observations of the eclipse from Greece, Egypt, and Li bya, and we demonstrate that the model accurately predicts the largescale structure of the corona. We also compare X-ray emission from the model with GOES/SXI images.

  9. A new concept and classification of corona mortis and its clinical significance.

    PubMed

    Al Talalwah, Waseem

    2016-10-01

    The obturator artery and its accessory (aberrant) arising from different origins and crossing the pubic rami are vascular variations. The internal iliac artery usually provides the obturator artery which may communicates with the external iliac artery through either the accessory obturator or inferior epigastric artery. A collateral circulation between the external and internal iliac system is known as corona mortis. The aim of current study is to provide sufficient data of vascular variability crossing the pubic rami for clinical field. Present study includes 208 hemipelvises dissected in the Institution of Anatomy, Medical University of Graz. During dissection, the obturator artery and its accessory crossing the superior rami of pubic bone were found to have different origins. The obturator artery arising from the external iliac artery and from the femoral artery accounts for 9.8% and 1.1% respectively. Therefore, it passes over the superior pubic rami in 10.9%. Further, the accessory (aberrant) artery arises only from the femoral artery in 1.1%. In present study, the vascular variation crossing the superior pubic rami with or without collateral circulation between external and internal iliac system referred as corona mortis is addressed. This study includes new classification of obturator and accessory obturator arteries as well as the corona mortis. It includes a comparison of corona mortis incidence in Austria population and other populations. The corona mortis found to be in 12% of Austrian population. A great attention of clinicians, radiologists, surgeons, orthopedic surgeons, obstetricians and gynecologists has to be considered before pubic surgical procedures such as internal fixation of pubic fracture, an inguinal hernia repair. Further, traumatic pubic rami fracture may lead to massive hemor- rhage due to laceration of the obturator artery.

  10. The role of charged particles in the positive corona-generated photon count in a rod to plane air gap

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bian, X. M.; Wang, Y. J.; MacAlpine, J. M. K.

    The relationship between the calculated charged-particle densities in positive corona, the rate of streamer production, and the photon count from the corona were investigated and found to be closely related. Both the densities of electrons and positive ions peaked at 11.8 kV, near the corona inception voltage; they then fell rapidly before slowly rising again. This behavior was exactly matched by the measured photon count. The calculation of the charged-particle density in a positive corona was achieved by means of a fluid model.

  11. The Intracellular Destiny of the Protein Corona: A Study on its Cellular Internalization and Evolution.

    PubMed

    Bertoli, Filippo; Garry, David; Monopoli, Marco P; Salvati, Anna; Dawson, Kenneth A

    2016-11-22

    It has been well established that the early stages of nanoparticle-cell interactions are governed, at least in part, by the layer of proteins and other biomolecules adsorbed and slowly exchanged with the surrounding biological media (biomolecular corona). Subsequent to membrane interactions, nanoparticles are typically internalized into the cell and trafficked along defined pathways such as, in many cases, the endolysosomal pathway. Indeed, if the original corona is partially retained on the nanoparticle surface, the biomolecules in this layer may play an important role in determining subsequent cellular processing. In this work, using a combination of organelle separation and fluorescence labeling of the initial extracellular corona, we clarify its intracellular evolution as nanoparticles travel within the cell. We show that specific proteins present in the original protein corona are retained on the nanoparticles until they accumulate in lysosomes, and, once there, they are degraded. We also report on how different bare surfaces (amino and carboxyl modified) affect the details of this evolution. One overarching discovery is that the same serum proteins can exhibit different intracellular processing when carried inside cells by nanoparticles, as components of their corona, compared to what is observed when they are transported freely from the extracellular medium.

  12. Tuning complement activation and pathway through controlled molecular architecture of dextran chains in nanoparticle corona.

    PubMed

    Coty, Jean-Baptiste; Eleamen Oliveira, Elquio; Vauthier, Christine

    2017-11-05

    The understanding of complement activation by nanomaterials is a key to a rational design of safe and efficient nanomedicines. This work proposed a systematic study investigating how molecular design of nanoparticle coronas made of dextran impacts on mechanisms that trigger complement activation. The nanoparticles used for this work consisted of dextran-coated poly(isobutylcyanoacrylate) (PIBCA) nanoparticles have already been thoroughly characterized. Their different capacity to trigger complement activation established on the cleavage of the protein C3 was also already described making these nanoparticles good models to investigate the relation between the molecular feature of their corona and the mechanism by which they triggered complement activation. Results of this new study show that complement activation pathways can be selected by distinct architectures formed by dextran chains composing the nanoparticle corona. Assumptions that explain the relation between complement activation mechanisms triggered by the nanoparticles and the nanoparticle corona molecular feature were proposed. These results are of interest to better understand how the design of dextran-coated nanomaterials will impact interactions with the complement system. It can open perspectives with regard to the selection of a preferential complement activation pathway or prevent the nanoparticles to activate the complement system, based on a rational choice of the corona configuration. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Interaction of gold and silver nanoparticles with human plasma: Analysis of protein corona reveals specific binding patterns.

    PubMed

    Lai, Wenjia; Wang, Qingsong; Li, Lumeng; Hu, Zhiyuan; Chen, Jiankui; Fang, Qiaojun

    2017-04-01

    Determining how nanomaterials interact with plasma will assist in understanding their effects on the biological system. This work presents a systematic study of the protein corona formed from human plasma on 20nm silver and gold nanoparticles with three different surface modifications, including positive and negative surface charges. The results show that all nanoparticles, even those with positive surface modifications, acquire negative charges after interacting with plasma. Approximately 300 proteins are identified on the coronas, while 99 are commonly found on each nanomaterial. The 20 most abundant proteins account for over 80% of the total proteins abundance. Remarkably, the surface charge and core of the nanoparticles, as well as the isoelectric point of the plasma proteins, are found to play significant roles in determining the nanoparticle coronas. Albumin and globulins are present at levels of less than 2% on these nanoparticle coronas. Fibrinogen, which presents in the plasma but not in the serum, preferably binds to negatively charged gold nanoparticles. These observations demonstrate the specific plasma protein binding pattern of silver and gold nanoparticles, as well as the importance of the surface charge and core in determining the protein corona compositions. The potential downstream biological impacts of the corona proteins were also investigated. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Electrons in the solar corona. III - Coronal streamers analysis from balloon-borne coronagraph

    NASA Astrophysics Data System (ADS)

    Dollfus, A.; Mouradian, Z.

    1981-03-01

    The solar corona is discussed on the basis of observations made during a 5-hour period in France in September 1971. Using a balloon at an altitude of 32,000 m, the solar corona was cinematographed from 2 to 5 solar radii with an externally occulted coronagraph. It is noted that motions in coronal features, when they occur, exhibit deformations of structures with velocities not exceeding a few tens of km/s. Several streamers were often involved simultaneously; these variations are compatible with magnetic changes or sudden reorganizations of lines of forces. Intensity and polarization measurements are shown to give the electron density with height in the quiet corona above the equator. Three-dimensional structures and localizations of the streamers are deduced from combined photometry, polarimetry, and ground-based K coronametry.

  15. Design for gas chromatography-corona discharge-ion mobility spectrometry.

    PubMed

    Jafari, Mohammad T; Saraji, Mohammad; Sherafatmand, Hossein

    2012-11-20

    A corona discharge ionization-ion mobility spectrometry (CD-IMS) with a novel sample inlet system was designed and constructed as a detector for capillary gas chromatography. In this design, a hollow needle was used instead of a solid needle which is commonly used for corona discharge creation, helping us to have direct axial interfacing for GC-IMS. The capillary column was passed through the needle, resulting in a reaction of effluents with reactant ions on the upstream side of the corona discharge ionization source. Using this sample introduction design, higher ionization efficiency was achieved relative to the entrance direction through the side of the drift tube. In addition, the volume of the ionization region was reduced to minimize the resistance time of compounds in the ionization source, increasing chromatographic resolution of the instrument. The effects of various parameters such as drift gas flow, makeup gas flow, and column tip position inside the needle were investigated. The designed instrument was exhaustively validated in terms of sensitivity, resolution, and reproducibility by analyzing the standard solutions of methyl isobutyl ketone, heptanone, nonanone, and acetophenone as the test compounds. The results obtained by CD-IMS detector were compared with those of the flame ionization detector, which revealed the capability of the proposed GC-IMS for two-dimensional separation (based on the retention time and drift time information) and identification of an analyte in complex matrixes.

  16. Modeling and characterization of field-enhanced corona discharge in ozone-generator diode

    NASA Astrophysics Data System (ADS)

    Patil, Jagadish G.; Vijayan, T.

    2010-02-01

    Electric field enhanced corona plasma discharge in ozone generator diode of axial symmetry has been investigated and characterized in theory. The cathode K of diode is made of a large number of sharpened nozzles arranged on various radial planes on the axial mast and pervaded in oxygen gas inside the anode cup A, produces high fields over MV/m and aids in the formation of a corona plume of dense ozone cloud over the cathode surface. An r-z finite difference scheme has been devised and employed to numerically determine the potential and electric field distributions inside the diode. The analyses of cathode emissions revealed a field emission domain conformed to modified Child-Langmuir diode-current. Passage of higher currents (over μA) in shorter A-K gaps d gave rise to cathode heated plasma extending from the corona to Saha regimes depending on local temperature. Plasma densities of order 102-106 m-3 are predicted in these. For larger d however, currents are smaller and heating negligible and a negative corona favoring ozone formation is attained. High ozone yields about 20 per cent of oxygen input is predicted in this domain. The generator so developed will be applied to various important applications such as, purification of ambient air /drinking water, ozone therapy, and so on.

  17. Nanoscale discharge electrode for minimizing ozone emission from indoor corona devices.

    PubMed

    Bo, Zheng; Yu, Kehan; Lu, Ganhua; Mao, Shun; Chen, Junhong; Fan, Fa-Gung

    2010-08-15

    Ground-level ozone emitted from indoor corona devices poses serious health risks to the human respiratory system and the lung function. Federal regulations call for effective techniques to minimize the indoor ozone production. In this work, stable atmospheric corona discharges from nanomaterials are demonstrated using horizontally suspended carbon nanotubes (CNTs) as the discharge electrode. Compared with the conventional discharges employing micro- or macroscale electrodes, the corona discharge from CNTs could initiate and operate at a much lower voltage due to the small electrode diameter, and is thus energy-efficient. Most importantly, the reported discharge is environmentally friendly since no ozone (below the detection limit of 0.5 ppb) was detected for area current densities up to 0.744 A/m(2) due to the significantly reduced number of electrons and plasma volume generated by CNT discharges. The resulting discharge current density depends on the CNT loading. Contrary to the conventional wisdom, negative CNT discharges should be used to enhance the current density owing to the efficient field emission of electrons from the CNT surface.

  18. Combined corona discharge and UV photoionization source for ion mobility spectrometry.

    PubMed

    Bahrami, Hamed; Tabrizchi, Mahmoud

    2012-08-15

    An ion mobility spectrometer is described which is equipped with two non-radioactive ion sources, namely an atmospheric pressure photoionization and a corona discharge ionization source. The two sources cannot only run individually but are additionally capable of operating simultaneously. For photoionization, a UV lamp was mounted parallel to the axis of the ion mobility cell. The corona discharge electrode was mounted perpendicular to the UV radiation. The total ion current from the photoionization source was verified as a function of lamp current, sample flow rate, and drift field. Simultaneous operation of the two ionization sources was investigated by recording ion mobility spectra of selected samples. The design allows one to observe peaks from either the corona discharge or photoionization individually or simultaneously. This makes it possible to accurately compare peaks in the ion mobility spectra from each individual source. Finally, the instrument's capability for discriminating two peaks appearing in approximately identical drift times using each individual ionization source is demonstrated. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. Adhesive Leaf Created by a Corona Discharge.

    PubMed

    Lee, Wonseok; Son, Jongsang; Kim, Seonghyun; Yang, Dongmin; Choi, Seungyeop; Watanabe, Rodrigo Akira; Hwang, Kyo Seon; Lee, Sang Woo; Lee, Gyudo; Yoon, Dae Sung

    2018-01-29

    Here, we report a new concept of both the adhesive manner and material, named "adhesive leaf (AL)," based on the leaf of the plant Heteropanax fragrans. The treatment of the corona discharge on the leaf surface can cause the nano-/microdestruction of the leaf epidermis, resulting in an outward release of sap. The glucose-containing sap provided the AL with a unique ability to stick to various substrates such as steel, polypropylene, and glass. Moreover, we reveal that the AL adhesion strength depends on the AL size, as well as the corona-discharge intensity. Conventional adhesives, such as glue and bond, lose their adhesive property and leave dirty residues upon the removal of the attached material. Unlike the conventional methods, the AL is advantageous as it can be repeatedly attached and detached thoroughly until the sap liquid is exhausted; its adhesive ability is maintained for at least three weeks at room temperature. Our findings shed light on a new concept of a biodegradable adhesive material that is created by a simple surface treatment.

  20. Reconnection Outflows in the Extended Corona and Magnetotail

    NASA Astrophysics Data System (ADS)

    Savage, Sabrina; Kobelski, Adam

    2017-08-01

    Observational signatures of reconnection have been studied extensively in the lower corona for decades, successfully providing insight into energy release mechanisms in the region above post-flare arcade loops and below 1.5 solar radii. During large eruptive events, however, energy release continues to occur well beyond the presence of reconnection signatures at these low heights. Supra-arcade downflows (SADs) and downflowing loops (SADLs) are particularly useful measures of continual reconnection in the corona as they may indicate the presence and path of retracting post-reconnection loops. SADs and SADLs have been observed for days beyond the passage of corona mass ejections through the SOHO/LASCO field of view and for nearly a week after an eruption on 14 October 2014. The association of these features with magnetic reconnection increases the significance of understanding their genesis. SADs have been interpreted as wakes behind newly reconnected and outflowing loops (SADLs). Models have shown the plausibility of this interpretation, though this interpretation has not yet been fully accepted. We will present a preliminary study of complementary observations of magnetic reconnection detected via in situ instruments in the magnetosphere. These observations, provided by five THEMIS spacecraft, reveal similar structures and conditions to those related to SADs. We compare data from multiple SADs and dipolarization fronts to test the similarity between these plasma regimes, strongly favoring the interpretation of SADs as instabilities trailing retracting loops. We will also use these observations to strengthen the case for the development of an EUV wide-field coronal imager.

  1. Vortex focusing of ions produced in corona discharge.

    PubMed

    Kolomiets, Yuri N; Pervukhin, Viktor V

    2013-06-15

    Completeness of the ion transportation into an analytical path defines the efficiency of ionization analysis techniques. This is of particular importance for atmospheric pressure ionization sources like corona discharge, electrospray, ionization with radioactive ((3)H, (63)Ni) isotopes that produce nonuniform spatial distribution of sample ions. The available methods of sample ion focusing are either efficient at reduced pressure (~1Torr) or feature high sample losses. This paper deals with experimental research into atmospheric pressure focusing of unipolar (positive) ions using a highly swirled air stream with a well-defined vortex core. Effects of electrical fields from corona needle and inlet capillary of mass spectrometer on collection efficiency is considered. We used a corona discharge to produce an ionized unipolar sample. It is shown experimentally that with an electrical field barrier efficient transportation and focusing of an ionized sample are possible only when a metal plate restricting the stream and provided with an opening covered with a grid is used. This gives a five-fold increase of the transportation efficiency. It is shown that the electric field barrier in the vortex sampling region reduces the efficiency of remote ionized sample transportation two times. The difference in the efficiency of light ion focusing observed may be explained by a high mobility and a significant effect of the electric field barrier upon them. It is possible to conclude based on the experimental data that the presence of the field barrier narrows considerably (more than by one and half) the region of the vortex sample ion focusing. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Polarimetry with Nanowires in the UV Solar Corona

    NASA Astrophysics Data System (ADS)

    Landini, Federico; Romoli, Marco; Baccani, Cristian; Dinescu, Adrian; Meneghin, Andrea; Scippa, Antonio; Pancrazzi, Maurizio; Focardi, Mauro; Landi Degl'Innocenti, Egidio

    2017-04-01

    The magnetic field in corona can be measured through the Hanle effect, which is the magnetic field induced modification of the linear polarization signals produced by anisotropic scattering processes. The HI Lyman α 121.6 nm is the most intense emission line of the EUV coronal spectrum, is formed by resonant scattering of the underlying chromospheric emission and is highly sensitive to the Hanle effect. Through the comparison between the measured and the expected polarization in the HI line it is possible to infer the magnetic field in corona. PENCIL (Polarimetry with Nanowires for Coronal Imaging of Ly α) may constitute the ideal candidate to measure the linear polarization of the whole Lyman α 121.6 nm corona. It is a transmitting polarimeter optimized for the Ly α 121.6 nm line, thought as part of an internally occulted coronagraph to be flown aboard a future small solar mission or a sounding rocket. It is a light device, completely free of mechanical moving parts, made by a fixed MgF2 quarter wave retarder, a nano-wire grid polarizer (nano-WGP) and a MgF2 variable retarder modulated through a calibrated piezo-clamp (PCVR). The nano-WGP and the PCVR are the two main components of PENCIL and represent a first-ever achievement in the history of technology development for VUV. New technological limits are being challenged in the development of such cutting edge devices. This contribution addresses the status of the project with particular emphasis on the design and manufacturing of the nano-WGP and the PCVR.

  3. Desorption corona beam ionization source for mass spectrometry.

    PubMed

    Wang, Hua; Sun, Wenjian; Zhang, Junsheng; Yang, Xiaohui; Lin, Tao; Ding, Li

    2010-04-01

    A novel Desorption Corona Beam Ionization (DCBI) source for direct analysis of samples from surface in mass spectrometry is reported. The DCBI source can work under ambient conditions without time-consuming sample pretreatments. The source shares some common features with another ionization source - Direct Analysis in Real Time (DART), developed earlier. For example, helium was used as the discharge gas (although only corona discharge is involved in the present source), and heating of the discharge gas is required for sample desorption. However, the difference between the two sources is substantial. In the present source, a visible thin corona beam extending out around 1 cm can be formed by using a hollow needle/ring electrode structure. This feature would greatly facilitate localizing sampling areas and performing imaging/profiling experiments. The DCBI source is also capable of performing progressive temperature scans between room temperature and 450 degrees C in order to sequentially desorb samples from the surface and, therefore, to achieve a rough separation of the individual components in a complex mixture, resulting in less congestion in the mass spectrum acquired. Mass spectra for a broad range of compounds (pesticides, veterinary additives, OTC drugs, explosive materials) have been acquired using the DCBI source. For most of the compounds tested, the heater temperature required for efficient desorption is at least 150 degrees C. The molecular weight of the sample that can be desorbed/ionized is normally below 600 dalton even at the highest heater temperature, which is mainly limited by the volatility of the sample.

  4. Flow generation by the corona ciliata in Chaetognatha - quantification and implications for current functional hypotheses.

    PubMed

    Bleich, Steffen; Müller, Carsten H G; Graf, Gerhard; Hanke, Wolf

    2017-12-01

    The corona ciliata of Chaetognatha (arrow worms) is a circular or elliptical groove lined by a rim from which multiple lines of cilia emanate, located dorsally on the head and/or trunk. Mechanoreception, chemosensation, excretion, respiration, and support of reproduction have been suggested to be its main functions. Here we provide the first experimental evidence that the cilia produce significant water flow, and the first visualisation and quantification of this flow. In Spadella cephaloptera, water is accelerated toward the corona ciliata from dorsal and anterior of the body in a funnel-shaped pattern, and expelled laterally and caudally from the corona, with part of the water being recirculated. Maximal flow speeds were approximately 140μms -1 in adult specimens. Volumetric flow rate was Q=0.0026μls -1 . The funnel-shaped directional flow can possibly enable directional chemosensation. The flow measurements demonstrate that the corona ciliata is well suited as a multifunctional organ. Copyright © 2017 Elsevier GmbH. All rights reserved.

  5. Greener corona discharge for enhanced wind generation with a simple dip-coated carbon nanotube decoration

    NASA Astrophysics Data System (ADS)

    Wu, Yishan; Li, Jun; Ye, Jianchun; Chen, Xiaohong; Li, Huili; Huang, Sumei; Zhao, Ran; Ou-Yang, Wei

    2017-10-01

    Corona discharge-induced wind (CDIW) has been widely utilized in production lines in the food and semiconductor industries and in indoor devices such as electrostatic precipitators. Some ozone is inevitably emitted, posing serious health risks to respiratory system and lung function of a human being. In this work, a greener corona discharge with enhanced wind generation for a needle-to-cylinder discharge structure is demonstrated using a simple dip-coating method to attach carbon nanotubes (CNTs) to the discharge electrode of a stainless steel needle. Compared with a conventional discharge electrode without CNT decoration, the velocity of the CDIW is greatly enhanced, the onset voltage is lowered, the energy conversion efficiency is greatly improved and the concentration of generated ozone is much reduced, making this easy method of CNT decoration a promising candidate for greener corona discharge systems. In addition, several impact factors for improved performance are discussed mathematically and phenomenologically, providing an insight into the corona discharge and wind generation.

  6. CDK5RAP2 Is an Essential Scaffolding Protein of the Corona of the Dictyostelium Centrosome.

    PubMed

    Pitzen, Valentin; Askarzada, Sophie; Gräf, Ralph; Meyer, Irene

    2018-04-23

    Dictyostelium centrosomes consist of a nucleus-associated cylindrical, three-layered core structure surrounded by a corona consisting of microtubule-nucleation complexes embedded in a scaffold of large coiled-coil proteins. One of them is the conserved CDK5RAP2 protein. Here we focus on the role of Dictyostelium CDK5RAP2 for maintenance of centrosome integrity, its interaction partners and its dynamic behavior during interphase and mitosis. GFP-CDK5RAP2 is present at the centrosome during the entire cell cycle except from a short period during prophase, correlating with the normal dissociation of the corona at this stage. RNAi depletion of CDK5RAP2 results in complete disorganization of centrosomes and microtubules suggesting that CDK5RAP2 is required for organization of the corona and its association to the core structure. This is in line with the observation that overexpressed GFP-CDK5RAP2 elicited supernumerary cytosolic MTOCs. The phenotype of CDK5RAP2 depletion was very reminiscent of that observed upon depletion of CP148, another scaffolding protein of the corona. BioID interaction assays revealed an interaction of CDK5RAP2 not only with the corona markers CP148, γ-tubulin, and CP248, but also with the core components Cep192, CP75, and CP91. Furthermore, protein localization studies in both depletion strains revealed that CP148 and CDK5RAP2 cooperate in corona organization.

  7. Analysis of Current Pulses in HeLa-Cell Permeabilization Due to High Voltage DC Corona Discharge.

    PubMed

    Chetty, Nevendra K; Chonco, Louis; Ijumba, Nelson M; Chetty, Leon; Govender, Thavendran; Parboosing, Raveen; Davidson, Innocent E

    2016-09-01

    Corona discharges are commonly utilized for numerous practical applications, including bio-technological ones. The corona induced transfer of normally impermeant molecules into the interior of biological cells has recently been successfully demonstrated. The exact nature of the interaction of the corona discharge with a cell membrane is still unknown, however, previous studies have suggested that it is either the electric fields produced by ions or the chemical interaction of the reactive species that result in the disruption of the cell membrane. This disruption of the cell membrane allows molecules to permeate into the cell. Corona discharge current constitutes a series of pulses, and it is during these pulses that the ions and reactive species are produced. It stands to reason, therefore, that the nature of these corona pulses would have an influence on the level of cell permeabilization and cell destruction. In this investigation, an analysis of the width, rise-time, characteristic frequencies, magnitude, and repetition rate of the nanosecond pulses was carried out in order to establish the relationship between these factors and the levels of cell membrane permeabilization and cell destruction. Results obtained are presented and discussed.

  8. Asymptotic analysis of corona discharge from thin electrodes

    NASA Technical Reports Server (NTRS)

    Durbin, P. A.

    1986-01-01

    The steady discharge of a high-voltage corona is analyzed as a singular perturbation problem. The small parameter is the ratio of the length of the ionization region to the total gap length. By this method, current versus voltage characteristics can be calculated analytically.

  9. Personalized liposome-protein corona in the blood of breast, gastric and pancreatic cancer patients.

    PubMed

    Colapicchioni, Valentina; Tilio, Martina; Digiacomo, Luca; Gambini, Valentina; Palchetti, Sara; Marchini, Cristina; Pozzi, Daniela; Occhipinti, Sergio; Amici, Augusto; Caracciolo, Giulio

    2016-06-01

    When nanoparticles (NPs) are dispersed in a biofluid, they are covered by a protein corona the composition of which strongly depends on the protein source. Recent studies demonstrated that the type of disease has a crucial role in the protein composition of the NP corona with relevant implications on personalized medicine. Proteomic variations frequently occur in cancer with the consequence that the bio-identity of NPs in the blood of cancer patients may differ from that acquired after administration to healthy volunteers. In this study we investigated the correlation between alterations of plasma proteins in breast, gastric and pancreatic cancer and the biological identity of clinically approved AmBisome-like liposomes as determined by a combination of dynamic light scattering, zeta potential analysis, one-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (1D-SDS-PAGE) and semi-quantitative densitometry. While size of liposome-protein complexes was not significantly different between cancer groups, the hard corona from pancreatic cancer patients was significantly less negatively charged. Of note, the hard corona from pancreatic cancer patients was more enriched than those of other cancer types this enrichment being most likely due to IgA and IgG with possible correlations with the autoantibodies productions in cancer. Given the strict relationship between tumor antigen-specific autoantibodies and early cancer detection, our results could be the basis for the development of novel nanoparticle-corona-based screening tests of cancer. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. [Morphology determination of multi-needle bipolar corona discharge by OES].

    PubMed

    Chen, Hai-Feng; Su, Peng-Hao; Zhu, Yi-Min

    2009-01-01

    Using the method of OES (optical emission spectrum) for measuring N2 emission spectrum, the spacial distribution of energetic electrons in multi-needle bipolar corona discharge at atmospheric pressure was investigated. According to the distribution of N2 second positive band's intensity ISPB, the outline of ionisation region was drawn accurately. The relationship between ISPB and discharge current I was obtained through the sum of ISPB. There are two ionisation regions in the multi-needle bipolar corona discharge. One is near the HV electrode and the other is near the grounded electrode. The ionisation region exists around the needlepoint within 2-3 mm. The volume of ionisation region becomes big with the applied voltage U increasing. The ionisation region of negative corona is bigger than that of positive corona. Near the HV discharge electrode, the outline of electron avalanche is similar to the configuration of electric field lines in the ionisation region, so the electron avalanche along the axis direction of needle develops farther than that along the radial direction. The electric field in the migration area is weak, and the distribution of space charges is large along the radial direction. The sum of ISPB in each ionisation region is second order linear with I, but the quadratic coefficient is very small. So the sum of ISPB is nearly linear with I, the distribution of ISPB is corresponding to the density distribution of energetic electrons. So the charged particles forming the discharge current in ionisation region are electrons. No emission spectrum of N2 can be measured in migration area, so there is no energetic electron. The energetic electrons only exist in ionisation region and the charged particles in migration area are ions.

  11. Acceleration region of the slow solar wind in corona

    NASA Astrophysics Data System (ADS)

    Abbo, L.; Antonucci, E.; Mikić, Z.; Riley, P.; Dodero, M. A.; Giordano, S.

    We present the results of a study concerning the physical parameters of the plasma of the extended corona in the low-latitude and equatorial regions, in order to investigate the sources of the slow solar wind during the minimum of solar activity. The equatorial streamer belt has been observed with the Ultraviolet Coronagraph Spectrometer (UVCS) onboard SOHO from August 19 to September 1, 1996. The spectroscopic diagnostic technique applied in this study, based on the OVI 1032, 1037 Ålines, allows us to determine both the solar wind velocity and the electron density of the extended corona. The main result of the analysis is the identification of the acceleration region of the slow wind, whose outflow velocity is measured in the range from 1.7 up to 3.5 solar radii.

  12. Properties of AGN coronae in the NuSTAR era - II. Hybrid plasma

    NASA Astrophysics Data System (ADS)

    Fabian, A. C.; Lohfink, A.; Belmont, R.; Malzac, J.; Coppi, P.

    2017-05-01

    The corona, a hot cloud of electrons close to the centre of the accretion disc, produces the hard X-ray power-law continuum commonly seen in luminous active galactic nuclei. The continuum has a high-energy turnover, typically in the range of one to several 100 keV and is suggestive of Comptonization by thermal electrons. We are studying hard X-ray spectra of AGN obtained with NuSTAR after correction for X-ray reflection and under the assumption that coronae are compact, being only a few gravitational radii in size as indicated by reflection and reverberation modelling. Compact coronae raise the possibility that the temperature is limited and indeed controlled by electron-positron pair production, as explored earlier (Paper I). Here, we examine hybrid plasmas in which a mixture of thermal and non-thermal particles is present. Pair production from the non-thermal component reduces the temperature leading to a wider temperature range more consistent with observations.

  13. Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy.

    PubMed

    Zhang, Zhengping; Wang, Chunming; Zha, Yinhe; Hu, Wei; Gao, Zhongfei; Zang, Yuhui; Chen, Jiangning; Zhang, Junfeng; Dong, Lei

    2015-03-24

    Strategies to modify nanoparticles with biological ligands for targeted drug delivery in vivo have been widely studied but met with limited clinical success. A possible reason is that, in the blood circulation, serum proteins could rapidly form a layer of protein "corona" on the vehicle surface, which might block the modified ligands and hamper their targeting functions. We speculate that strategies for drug delivery can be designed based upon elegant control of the corona formation on the vehicle surfaces. In this study, we demonstrate a retinol-conjugated polyetherimine (RcP) nanoparticle system that selectively recruited the retinol binding protein 4 (RBP) in its corona components. RBP was found to bind retinol, and direct the antisense oligonucleotide (ASO)-laden RcP carrier to hepatic stellate cells (HSC), which play essential roles in the progression of hepatic fibrosis. In both mouse fibrosis models, induced by carbon tetrachloride (CCl4) and bile duct ligation (BDL), respectively, the ASO-laden RcP particles effectively suppressed the expression of type I collagen (collagen I), and consequently ameliorated hepatic fibrosis. Such findings suggest that this delivery system, designed to exploit the power of corona proteins, can serve as a promising tool for targeted delivery of therapeutic agents for the treatment of hepatic fibrosis.

  14. Corona discharges with water electrospray for Escherichia coli biofilm eradication on a surface.

    PubMed

    Kovalova, Zuzana; Leroy, Magali; Kirkpatrick, Michael J; Odic, Emmanuel; Machala, Zdenko

    2016-12-01

    Low-temperature plasma (cold), a new method for the decontamination of surfaces, can be an advantageous alternative to the traditional chemical methods, autoclave or dry heat. Positive and negative corona discharges in air were tested for the eradication of 48-h Escherichia coli biofilms grown on glass slides. The biofilms were treated by cold corona discharge plasma for various exposure times. Water electrospray from the high voltage electrode was applied in some experiments. Thermostatic cultivation of the biofilm, and confocal laser scanning microscopy (CLSM) of the biofilm stained with fluorescent dyes were used for biocidal efficiency quantification. Up to 5 log10 reduction of bacterial concentration in the biofilm was measured by thermostatic cultivation after exposure to both corona discharges for 15min. This decontamination efficiency was significantly enhanced by simultaneous water electrospray through the plasma. CLSM showed that the live/dead ratio after treatment remained almost constant inside the biofilm; only cells on the top layers of the biofilm were affected. DAPI fluorescence showed that biofilm thickness was reduced by about 1/3 upon exposure to the corona discharges with electrospray for 15min. The biofilm biomass loss by about 2/3 was confirmed by crystal violet assay. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Surface-initiated graft polymerization on multiwalled carbon nanotubes pretreated by corona discharge at atmospheric pressure.

    PubMed

    Xu, Lihua; Fang, Zhengping; Song, Ping'an; Peng, Mao

    2010-03-01

    Surface-initiated graft polymerization on multi-walled carbon nanotubes pretreated with a corona discharge at atmospheric pressure was explored. The mechanism of the corona-discharge-induced graft polymerization is discussed. The results indicate that MWCNTs were encapsulated by poly(glycidyl methacrylate) (PGMA), demonstrating the formation of PGMA-grafted MWCNTs (PGMA-g-MWCNTs), with a grafting ratio of about 22 wt%. The solubility of PGMA-g-MWCNTs in ethanol was dramatically improved compared to pristine MWCNTs, which could contribute to fabricating high-performance polymer/MWCNTs nanocomposites in the future. Compared with most plasma processes, which operate at low pressures, corona discharge has the merit of working at atmospheric pressure.

  16. The structure of the white-light corona and the large-scale solar magnetic field

    NASA Technical Reports Server (NTRS)

    Sime, D. G.; Mccabe, M. K.

    1990-01-01

    The large-scale density structure of the white-light solar corona is compared to the organization of the solar magnetic field as identified by the appearance of neutral lines in the photosphere to examine whether any consistent relationship exists between the two. During the period covering Carrington rotations 1717 to 1736 brightness enhancements in the low corona tend to lie over the global neutral sheet identified in the photospheric magnetic field. The brightest of these enhancements are associated with neutral lines throguh active regions. These associations are not 1-1, but do hold both in stable and evolving conditions of the corona. A significant number of long-lived neutral lines is found, including filaments seen in H-alpha, for which there are not coronal enhancements.

  17. Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction.

    PubMed

    Inoue, Tomoyuki; Hara, Yuko; Kobayashi, Takeshi; Zheng, Xiaodong; Suzuki, Takashi; Shiraishi, Atsushi; Ohashi, Yuichi

    2016-09-01

    To describe a characteristic form of the corona sign and its clinical relevance to the degree of corneal endothelial decompensation and investigate the underlying mechanism using a rabbit model. These observational cases include 31 patients undergoing penetrating keratoplasty (PKP) and 15 patients undergoing Descemet stripping automated endothelial keratoplasty (DSAEK) with special attention to the circumferentially developed corneal epithelial edema. We also conducted a laboratory observation of horizontal water flow in the rabbit cornea. We consistently observed the corona sign at the superior periphery during the initial stage of corneal endothelial decompensation after PKP. With progressive corneal endothelial cellular loss, the epithelial edema gradually expanded circumferentially in the periphery. The endothelial cellular density associated with the corona sign significantly (P < 0.01) decreased compared with that without the sign. The endothelial cellular density decreased significantly (P < 0.05) in cases with a circumferential corona sign compared with a superior corona sign. After DSAEK, however, the corneal epithelial edema subsided from the center but persisted peripherally as a corona sign in all cases. By 3 months postoperatively, the epithelial edema was confined to the superior periphery along with uneventful corneal endothelial healing. Rabbit experiments showed that total corneal endothelial decompensation decreased the horizontal intracorneal water migration (Inoue-Ohashi phenomenon) in the corneal periphery and induced peripheral corneal edema. The slit-lamp microscopic findings of the corona-like epithelial edema in the peripheral cornea are associated with the stage of corneal endothelial function. To support this, the developmental mechanism of the corona sign was demonstrated experimentally.

  18. [Morphology determination of multi-needle-to-plate positive corona discharge].

    PubMed

    Su, Peng-hao; Zhu, Yi-min; Chen, Hai-feng

    2008-09-01

    Using the method of OES (optical emission spectrum) for measuring N2 emission spectrum, the distribution of the energetic electrons in multi-needle-to-plate positive corona discharge at atmospheric pressure was investigated, and compared with that in negative corona discharge. According to the distribution of N2 second positive band's intensity I(SPB), the outline of the ionization region in glow discharge and the streamer channel were drawn rather accurately. The relationship between I(SPB) and the discharge current I in glow discharge can be obtained through the volume integral of the I(SPB). In glow discharge, both the ionization region scale and I(SPB) are smaller than in negative corona discharge, the electron avalanche develops farther along the radius direction of needle than along axis direction, and only the arrange along axis direction is enhanced slightly with the rise of the applied voltage U. The integral of I(SPB) is second order linear to I. In streamer discharge, the discharge channels develop from needlepoint to the plate, while the shape of the region in which I(SPB) is higher looks like a bullet. The density of energetic electron in the channel farther away from the needlepoint is relatively uniform along the axis direction, but first increases then decreases along the radius direction.

  19. Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages

    PubMed Central

    Vogt, Carmen; Pernemalm, Maria; Kohonen, Pekka; Laurent, Sophie; Hultenby, Kjell; Vahter, Marie; Lehtiö, Janne; Toprak, Muhammet S.; Fadeel, Bengt

    2015-01-01

    Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as promising contrast agents for magnetic resonance imaging. The influence of different surface coatings on the biocompatibility of SPIONs has been addressed, but the potential impact of the so-called corona of adsorbed proteins on the surface of SPIONs on their biological behavior is less well studied. Here, we determined the composition of the plasma protein corona on silica-coated versus dextran-coated SPIONs using mass spectrometry-based proteomics approaches. Notably, gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed distinct protein corona compositions for the two different SPIONs. Relaxivity of silica-coated SPIONs was modulated by the presence of a protein corona. Moreover, the viability of primary human monocyte-derived macrophages was influenced by the protein corona on silica-coated, but not dextran-coated SPIONs, and the protein corona promoted cellular uptake of silica-coated SPIONs, but did not affect internalization of dextran-coated SPIONs. PMID:26444829

  20. Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages.

    PubMed

    Vogt, Carmen; Pernemalm, Maria; Kohonen, Pekka; Laurent, Sophie; Hultenby, Kjell; Vahter, Marie; Lehtiö, Janne; Toprak, Muhammet S; Fadeel, Bengt

    2015-01-01

    Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as promising contrast agents for magnetic resonance imaging. The influence of different surface coatings on the biocompatibility of SPIONs has been addressed, but the potential impact of the so-called corona of adsorbed proteins on the surface of SPIONs on their biological behavior is less well studied. Here, we determined the composition of the plasma protein corona on silica-coated versus dextran-coated SPIONs using mass spectrometry-based proteomics approaches. Notably, gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed distinct protein corona compositions for the two different SPIONs. Relaxivity of silica-coated SPIONs was modulated by the presence of a protein corona. Moreover, the viability of primary human monocyte-derived macrophages was influenced by the protein corona on silica-coated, but not dextran-coated SPIONs, and the protein corona promoted cellular uptake of silica-coated SPIONs, but did not affect internalization of dextran-coated SPIONs.

  1. The prevalence and morphology of the corona mortis (Crown of death): A meta-analysis with implications in abdominal wall and pelvic surgery.

    PubMed

    Sanna, Beatrice; Henry, Brandon Michael; Vikse, Jens; Skinningsrud, Bendik; Pękala, Jakub R; Walocha, Jerzy A; Cirocchi, Roberto; Tomaszewski, Krzysztof A

    2018-02-01

    Corona mortis is a highly variable vascular connection between the obturator and external iliac or inferior epigastric arteries or veins located behind the superior pubic ramus in the retropubic space (space of Retzius). Due to the significant variation in this collateral circulation, detailed anatomical knowledge of the corona mortis is vital to enhance the prevention of possible iatrogenic errors in hernia repair and other pubic surgical procedures. The aim of our meta-analysis was to provide comprehensive data on the prevalence, anatomical characteristics, and ethnic variations of the corona mortis vessel. An extensive search was conducted through the major electronic databases to identify eligible articles. Data extracted included investigative method, prevalence of the corona mortis vessels among hemi-pelvises (overall, arterial only, venous only, and combined), distance from the corona mortis to pubic symphysis, and assessment of gender, side, laterality, and ethnicity subgroups. A total of 21 studies (n=2184 hemi-pelvises) were included in the meta-analysis. The overall prevalence of the corona mortis in hemi-pelvises is high (49.3%). A venous corona mortis is more prevalent than an arterial corona mortis (41.7% vs. 17.0%). The corona mortis is more common in Asia (59.3%) than in Europe (42.8%) and North America (44.3%). As a corona mortis is present in an about half of all hemi-pelvises, it is important to consider the possibilities of its presence when undertaking surgical procedures and plan accordingly to avoid injuries. All surgeons operating in the retropubic region should have a thorough understanding of the anatomical characteristics and surgical implications of a corona mortis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Heating of the Solar Corona and its Loops

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2009-01-01

    At several million degrees, the solar corona is more than two orders of magnitude hotter than the underlying solar surface. The reason for these extreme conditions has been a puzzle for decades and is considered one of the fundamental problems in astrophysics. Much of the coronal plasma is organized by the magnetic field into arch-like structures called loops. Recent observational and theoretical advances have led to great progress in understanding the nature of these loops. In particular, we now believe they are bundles of unresolved magnetic strands that are heated by storms of impulsive energy bursts called nanoflares. Turbulent convection at the solar surface shuffles the footpoints of the strands and causes them to become tangled. A nanoflare occurs when the magnetic stresses reach a critical threshold, probably by way of a mechanism called the secondary instability. I will describe our current state of knowledge concerning the corona, its loops, and how they are heated.

  3. The Structure and Dynamics of the Solar Corona

    NASA Technical Reports Server (NTRS)

    Mikic, Zoran

    2000-01-01

    This report covers technical progress during the third year of the NASA Space Physics Theory contract "The Structure and Dynamics of the Solar Corona," between NASA and Science Applications International Corporation, and covers the period June 16, 1998 to August 15, 1999. This is also the final report for this contract. Under this contract SAIC, the University of California, Irvine (UCI), and the Jet Propulsion Laboratory (JPL), have conducted research into theoretical modeling of active regions, the solar corona, and the inner heliosphere, using the MHD model. During the three-year duration of this contract we have published 49 articles in the scientific literature. These publications are listed in Section 3 of this report. In the Appendix we have attached reprints of selected articles. We summarize our progress during the third year of the contract. Full descriptions of our work can be found in the cited publications, a few of which are attached to this report.

  4. Ligand Size and Conformation Affect the Behavior of Nanoparticles Coated with in Vitro and in Vivo Protein Corona.

    PubMed

    Zhang, Huajin; Wu, Tianmu; Yu, Wenqi; Ruan, Shaobo; He, Qin; Gao, Huile

    2018-03-14

    Protein corona is immediately established on the surface of nanoparticles upon their introduction into biological milieu. Several studies have shown that the targeting efficiency of ligand-modified nanoparticles is attenuated or abolished owing to the protein adsorption. Here, transferrin receptor-targeting ligands, including LT7 (CHAIYPRH), DT7 (hrpyiahc, all d-form amino acids), and transferrin, were used to identify the influence of the ligand size and conformation on protein corona formation. The results showed that the targeting capacity of ligand-modified nanoparticles was lost after incubation with plasma in vitro, whereas it was partially retained after in vivo corona formation. Results from sodium dodecyl sulfate polyacrylamide gel electrophoresis and liquid chromatography-mass spectrometry revealed the difference in the composition of in vitro and in vivo corona, wherein the ligand size and conformation played a critical role. Differences were observed in cellular internalization and exocytosis profiles on the basis of the ligand and corona source.

  5. Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner.

    PubMed

    Cheng, Xiaju; Tian, Xin; Wu, Anqing; Li, Jianxiang; Tian, Jian; Chong, Yu; Chai, Zhifang; Zhao, Yuliang; Chen, Chunying; Ge, Cuicui

    2015-09-23

    The interaction at nanobio is a critical issue in designing safe nanomaterials for biomedical applications. Recent studies have reported that it is nanoparticle-protein corona rather than bare nanoparticle that determines the nanoparticle-cell interactions, including endocytic pathway and biological responses. Here, we demonstrate the effects of protein corona on cellular uptake of different sized gold nanoparticles in different cell lines. The experimental results show that protein corona significantly decreases the internalization of Au NPs in a particle size- and cell type-dependent manner. Protein corona exhibits much more significant inhibition on the uptake of large-sized Au NPs by phagocytic cell than that of small-sized Au NPs by nonphagocytic cell. The endocytosis experiment indicates that different endocytic pathways might be responsible for the differential roles of protein corona in the interaction of different sized Au NPs with different cell lines. Our findings can provide useful information for rational design of nanomaterials in biomedical application.

  6. Effect of corona discharge on the gas composition of the sample flow in a Gas Particle Partitioner.

    PubMed

    Asbach, Christof; Kuhlbusch, Thomas A J; Fissan, Heinz

    2005-09-01

    A Gas Particle Partitioner (GPP) that allows highly efficient separation of gas and particles with no effect on the thermodynamic conditions and substantially no change of the gas composition has been developed. The GPP is a coaxial arrangement with inner and outer electrodes and utilizes a corona discharge to electrically charge the particles and a strong electric field to remove them from the sample flow. Several measures were taken to avoid an influence of the corona discharge on the gas composition. The GPP can be applied for various applications. This paper focuses on the use of the GPP as a pre-filter for gas analyzers, where zero pressure drop and a minimization of the influence of the corona discharge on the gas composition are the main objective. Due to its design, the GPP introduces no changes to the thermodynamic conditions. However, corona discharge is known to produce significant amounts of ozone and oxides of nitrogen. The effect of the corona on the gas composition of the sample flow was determined under various conditions. The gas concentrations strongly depended on several aspects, such as material and diameter of the corona wire and polarity of the corona voltage. Due to the measures taken to minimize an effect on the gas composition, the concentrations of these gases could effectively be reduced. Along with the maximum gas-particle separation efficiency of near 100%, the additional O3 concentration was 42 ppbV and the additional NO2 concentration 15 ppbV. If an efficiency of 95% is acceptable, the added concentrations can be as low as 2.5 ppbV (O3) and 0.5 ppbV (NO2), respectively.

  7. Inbound waves in the solar corona: A direct indicator of Alfvén surface location

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DeForest, C. E.; Howard, T. A.; McComas, D. J., E-mail: deforest@boulder.swri.edu

    The tenuous supersonic solar wind that streams from the top of the corona passes through a natural boundary—the Alfvén surface—that marks the causal disconnection of individual packets of plasma and magnetic flux from the Sun itself. The Alfvén surface is the locus where the radial motion of the accelerating solar wind passes the radial Alfvén speed, and therefore any displacement of material cannot carry information back down into the corona. It is thus the natural outer boundary of the solar corona and the inner boundary of interplanetary space. Using a new and unique motion analysis to separate inbound and outboundmore » motions in synoptic visible-light image sequences from the COR2 coronagraph on board the STEREO-A spacecraft, we have identified inbound wave motion in the outer corona beyond 6 solar radii for the first time and used it to determine that the Alfvén surface is at least 12 solar radii from the Sun over the polar coronal holes and 15 solar radii in the streamer belt, well beyond the distance planned for NASA's upcoming Solar Probe Plus mission. To our knowledge, this is the first measurement of inbound waves in the outer solar corona and the first direct measurement of lower bounds for the Alfvén surface.« less

  8. Direct Impact Corona Ionization of Bacteria for Rapid, Reproducible Identification via Spectral Pattern Recognition

    NASA Astrophysics Data System (ADS)

    Alusta, Pierre; Buzatu, Dan; Tarasenko, Olga; Wilkes, Jon; Darsey, Jerry

    2011-06-01

    A novel atmospheric pressure ionization process, Direct Impact Corona Ionization (DICI), is described here. In this process, a corona impinges onto the flat surface of a stainless steel pin carrying a thin film of dried bacterial suspension, the analyte. Two electrodes—a corona electrode and the sample pin—are immersed in hot inert He gas flux, flowing past them towards a 0.4 mm orifice leading to a mass spectrometer analyzer. An electric potential of 1.5-3.0 kV is placed between the two. At distances less than 1 cm, an intermittent arc is formed. At approximately 4 mm, the arc becomes a continuous corona discharge (plasma). The plasma is hot enough to: A) locally melt the impact zone on the steel pin, and B) ablate the dry thin bacterial film deposited on the metal pin. Biomolecular ions as heavy as 790 m/z are generated. Mass spectral fingerprints of bacteria are obtained with a high degree of reproducibility by selecting the highest intensity of an "indicator ion", 560.5 m/z or another relatively heavy ion whose appearance signals efficient vaporization of low volatility components.

  9. The on-bead digestion of protein corona on nanoparticles by trypsin immobilized on the magnetic nanoparticle.

    PubMed

    Hu, Zhengyan; Zhao, Liang; Zhang, Hongyan; Zhang, Yi; Wu, Ren'an; Zou, Hanfa

    2014-03-21

    Proteins interacting with nanoparticles would form the protein coronas on the surface of nanoparticles in biological systems, which would critically impact the biological identities of nanoparticles and/or result in the physiological and pathological consequences. The enzymatic digestion of protein corona was the primary step to achieve the identification of protein components of the protein corona for the bottom-up proteomic approaches. In this study, the investigation on the tryptic digestion of protein corona by the immobilized trypsin on a magnetic nanoparticle was carried out for the first time. As a comparison with the usual overnight long-time digestion and the severe self-digestion of free trypsin, the on-bead digestion of protein corona by the immobilized trypsin could be accomplished within 1h, along with the significantly reduced self-digestion of trypsin and the improved reproducibility on the identification of proteins by the mass spectrometry-based proteomic approach. It showed that the number of identified bovine serum (BS) proteins on the commercial Fe3O4 nanoparticles was increased by 13% for the immobilized trypsin with 1h digestion as compared to that of using free trypsin with even overnight digestion. In addition, the on-bead digestion of using the immobilized trypsin was further applied on the identification of human plasma protein corona on the commercial Fe3O4 nanoparticles, which leads the efficient digestion of the human plasma proteins and the identification of 149 human plasma proteins corresponding to putative critical pathways and biological processes. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. The Slowly Varying Corona. I. Daily Differential Emission Measure Distributions Derived from EVE Spectra

    NASA Astrophysics Data System (ADS)

    Schonfeld, S. J.; White, S. M.; Hock-Mysliwiec, R. A.; McAteer, R. T. J.

    2017-08-01

    Daily differential emission measure (DEM) distributions of the solar corona are derived from spectra obtained by the Extreme-ultraviolet Variability Experiment (EVE) over a 4 yr period starting in 2010 near solar minimum and continuing through the maximum of solar cycle 24. The DEMs are calculated using six strong emission features dominated by Fe lines of charge states viii, ix, xi, xii, xiv, and xvi that sample the nonflaring coronal temperature range 0.3-5 MK. A proxy for the non-Fe xviii emission in the wavelength band around the 93.9 Å line is demonstrated. There is little variability in the cool component of the corona (T < 1.3 MK) over the 4 yr, suggesting that the quiet-Sun corona does not respond strongly to the solar cycle, whereas the hotter component (T > 2.0 MK) varies by more than an order of magnitude. A discontinuity in the behavior of coronal diagnostics in 2011 February-March, around the time of the first X-class flare of cycle 24, suggests fundamentally different behavior in the corona under solar minimum and maximum conditions. This global state transition occurs over a period of several months. The DEMs are used to estimate the thermal energy of the visible solar corona (of order 1031 erg), its radiative energy loss rate ((2.5-8) × {10}27 erg s-1), and the corresponding energy turnover timescale (about an hour). The uncertainties associated with the DEMs and these derived values are mostly due to the coronal Fe abundance and density and the CHIANTI atomic line database.

  11. Planning Through Incrementalism

    ERIC Educational Resources Information Center

    Lasserre, Ph.

    1974-01-01

    An incremental model of decisionmaking is discussed and compared with the Comprehensive Rational Approach. A model of reconciliation between the two approaches is proposed, and examples are given in the field of economic development and educational planning. (Author/DN)

  12. Photometric intensity and polarization measurements of the solar corona.

    NASA Technical Reports Server (NTRS)

    Mcdougal, D. S.

    1971-01-01

    Use of a satellite photometric observatory (SPO) to measure the solar corona from Miahuatlan, Mexico during the Mar. 7, 1970, total eclipse of the sun. The SPO is equipped with a 24-in. Cassegrainian telescope, a four-channel photoelectric photometer, a Wollaston prism, and a rotating half-wave plate. Simultaneous measurements were made of the two orthogonal components of coronal light in the B and R bands of the UBVRI system. A 1-minute arc aperture was scanned from the lunar disk center out to five solar radii in a series of spirals of gradually increasing radius. For the first time, simultaneous multicolor intensity, degree, and angle of polarization profiles are computed from photoelectric measurements. Comparison of the variations of the measurements for each spiral scan yield a detailed picture of the intensity and polarization features in the K corona.

  13. Corona method and apparatus for altering carbon containing compounds

    DOEpatents

    Sharma, Amit K.; Camaioni, Donald M.; Josephson, Gary B.

    1999-01-01

    The present invention is a method and apparatus for altering a carbon containing compound in an aqueous mixture. According to a first aspect of the present invention, it has been discovered that for an aqueous mixture having a carbon containing compound with an ozone reaction rate less than the ozone reaction rate of pentachlorophenol, use of corona discharge in a low or non-oxidizing atmosphere increases the rate of destruction of the carbon containing compound compared to corona discharge an oxidizing atmosphere. For an aqueous mixture containing pentachlorphenol, there was essentially no difference in destruction between atmospheres. According to a second aspect of the present invention, it has been further discovered that an aqueous mixture having a carbon containing compound in the presence of a catalyst and oxygen resulted in an increased destruction rate of the carbon containing compound compared to no catalyst.

  14. Corona Method And Apparatus For Altering Carbon Containing Compounds

    DOEpatents

    Sharma, Amit K.; Camaioni, Donald M.; Josephson; Gary B.

    2004-05-04

    The present invention is a method and apparatus for altering a carbon-containing compound in an aqueous mixture. According to a first aspect of the present invention, it has been discovered that for an aqueous mixture having a carbon containing compound with an ozone reaction rate less than the ozone reaction rate of pentachlorophenol, use of corona discharge in a low or non-oxidizing atmosphere increases the rate of destruction of the carbon containing compound compared to corona discharge an oxidizing atmosphere. For an aqueous mixture containing pentachlorphenol, there was essentially no difference in destruction between atmospheres. According to a second aspect of the present invention, it has been further discovered that an aqueous mixture having a carbon-containing compound in the presence of a catalyst and oxygen resulted in an increased destruction rate of the carbon containing compound compared to no catalyst.

  15. Size-Dependent Protein-Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona.

    PubMed

    Piella, Jordi; Bastús, Neus G; Puntes, Víctor

    2017-01-18

    Surface modifications of highly monodisperse citrate-stabilized gold nanoparticles (AuNPs) with sizes ranging from 3.5 to 150 nm after their exposure to cell culture media supplemented with fetal bovine serum were studied and characterized by the combined use of UV-vis spectroscopy, dynamic light scattering, and zeta potential measurements. In all the tested AuNPs, a dynamic process of protein adsorption was observed, evolving toward the formation of an irreversible hard protein coating known as Protein Corona. Interestingly, the thickness and density of this protein coating were strongly dependent on the particle size, making it possible to identify different transition regimes as the size of the particles increased: (i) NP-protein complexes (or incomplete corona), (ii) the formation of a near-single dense protein corona layer, and (iii) the formation of a multilayer corona. In addition, the different temporal patterns in the evolution of the protein coating came about more quickly for small particles than for the larger ones, further revealing the significant role that size plays in the kinetics of this process. Since the biological identity of the NPs is ultimately determined by the protein corona and different NP-biological interactions take place at different time scales, these results are relevant to biological and toxicological studies.

  16. STEREO OBSERVATIONS OF FAST MAGNETOSONIC WAVES IN THE EXTENDED SOLAR CORONA ASSOCIATED WITH EIT/EUV WAVES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kwon, Ryun-Young; Ofman, Leon; Kramar, Maxim

    2013-03-20

    We report white-light observations of a fast magnetosonic wave associated with a coronal mass ejection observed by STEREO/SECCHI/COR1 inner coronagraphs on 2011 August 4. The wave front is observed in the form of density compression passing through various coronal regions such as quiet/active corona, coronal holes, and streamers. Together with measured electron densities determined with STEREO COR1 and Extreme UltraViolet Imager (EUVI) data, we use our kinematic measurements of the wave front to calculate coronal magnetic fields and find that the measured speeds are consistent with characteristic fast magnetosonic speeds in the corona. In addition, the wave front turns outmore » to be the upper coronal counterpart of the EIT wave observed by STEREO EUVI traveling against the solar coronal disk; moreover, stationary fronts of the EIT wave are found to be located at the footpoints of deflected streamers and boundaries of coronal holes, after the wave front in the upper solar corona passes through open magnetic field lines in the streamers. Our findings suggest that the observed EIT wave should be in fact a fast magnetosonic shock/wave traveling in the inhomogeneous solar corona, as part of the fast magnetosonic wave propagating in the extended solar corona.« less

  17. Shock Formation Height in the Solar Corona Estimated from SDO and Radio Observations

    NASA Technical Reports Server (NTRS)

    Gopalswamy, N.; Nitta, N.

    2011-01-01

    Wave transients at EUV wavelengths and type II radio bursts are good indicators of shock formation in the solar corona. We use recent EUV wave observations from SDO and combine them with metric type II radio data to estimate the height in the corona where the shocks form. We compare the results with those obtained from other methods. We also estimate the shock formation heights independently using white-light observations of coronal mass ejections that ultimately drive the shocks.

  18. Time-evolution of in vivo protein corona onto blood-circulating PEGylated liposomal doxorubicin (DOXIL) nanoparticles.

    PubMed

    Hadjidemetriou, Marilena; Al-Ahmady, Zahraa; Kostarelos, Kostas

    2016-04-07

    Nanoparticles (NPs) are instantly modified once injected in the bloodstream because of their interaction with the blood components. The spontaneous coating of NPs by proteins, once in contact with biological fluids, has been termed the 'protein corona' and it is considered to be a determinant factor for the pharmacological, toxicological and therapeutic profile of NPs. Protein exposure time is thought to greatly influence the composition of protein corona, however the dynamics of protein interactions under realistic, in vivo conditions remain unexplored. The aim of this study was to quantitatively and qualitatively investigate the time evolution of in vivo protein corona, formed onto blood circulating, clinically used, PEGylated liposomal doxorubicin. Protein adsorption profiles were determined 10 min, 1 h and 3 h post-injection of liposomes into CD-1 mice. The results demonstrated that a complex protein corona was formed as early as 10 min post-injection. Even though the total amount of protein adsorbed did not significantly change over time, the fluctuation of protein abundances observed indicated highly dynamic protein binding kinetics.

  19. Radial distribution of compressive waves in the solar corona revealed by Akatsuki radio occultation observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miyamoto, Mayu; Imamura, Takeshi; Ando, Hiroki

    Radial variations of the amplitude and the energy flux of compressive waves in the solar corona were explored for the first time using a spacecraft radio occultation technique. By applying wavelet analysis to the frequency time series taken at heliocentric distances of 1.5-20.5 R{sub S} (solar radii), quasi-periodic density disturbances were detected at almost all distances. The period ranges from 100 to 2000 s. The amplitude of the fractional density fluctuation increases with distance and reaches ∼30% around 5 R{sub S} , implying that nonlinearity of the wave field is potentially important. We further estimate the wave energy flux onmore » the assumption that the observed periodical fluctuations are manifestations of acoustic waves. The energy flux increases with distance below ∼6 R{sub S} and seems to saturate above this height, suggesting that the acoustic waves do not propagate from the low corona but are generated in the extended corona, probably through nonlinear dissipation of Alfvén waves. The compressive waves should eventually dissipate through shock generation to heat the corona.« less

  20. 26 CFR 1.41-8 - Alternative incremental credit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Alternative incremental credit. 1.41-8 Section 1... Credits Against Tax § 1.41-8 Alternative incremental credit. (a) Determination of credit. At the election... alternative incremental research credit (AIRC) in section 41(c)(4) for any taxable year of the taxpayer...

  1. The Protein Corona around Nanoparticles Facilitates Stem Cell Labeling for Clinical MR Imaging.

    PubMed

    Nejadnik, Hossein; Taghavi-Garmestani, Seyed-Meghdad; Madsen, Steven J; Li, Kai; Zanganeh, Saeid; Yang, Phillip; Mahmoudi, Morteza; Daldrup-Link, Heike E

    2018-03-01

    Purpose To evaluate if the formation of a protein corona around ferumoxytol nanoparticles can facilitate stem cell labeling for in vivo tracking with magnetic resonance (MR) imaging. Materials and Methods Ferumoxytol was incubated in media containing human serum (group 1), fetal bovine serum (group 2), StemPro medium (group 3), protamine (group 4), and protamine plus heparin (group 5). Formation of a protein corona was characterized by means of dynamic light scattering, ζ potential, and liquid chromatography-mass spectrometry. Iron uptake was evaluated with 3,3'-diaminobenzidine-Prussian blue staining, lysosomal staining, and inductively coupled plasma spectrometry. To evaluate the effect of a protein corona on stem cell labeling, human mesenchymal stem cells (hMSCs) were labeled with the above formulations, implanted into pig knee specimens, and investigated with T2-weighted fast spin-echo and multiecho spin-echo sequences on a 3.0-T MR imaging unit. Data in different groups were compared by using a Kruskal-Wallis test. Results Compared with bare nanoparticles, all experimental groups showed significantly increased negative ζ values (from -37 to less than -10; P = .008). Nanoparticles in groups 1-3 showed an increased size because of the formation of a protein corona. hMSCs labeled with group 1-5 media showed significantly shortened T2 relaxation times compared with unlabeled control cells (P = .0012). hMSCs labeled with group 3 and 5 media had the highest iron uptake after cells labeled with group 1 medium. After implantation into pig knees, hMSCs labeled with group 1 medium showed significantly shorter T2 relaxation times than hMSCs labeled with group 2-5 media (P = .0022). Conclusion The protein corona around ferumoxytol nanoparticles can facilitate stem cell labeling for clinical cell tracking with MR imaging. © RSNA, 2017 Online supplemental material is available for this article.

  2. Protein source and choice of anticoagulant decisively affect nanoparticle protein corona and cellular uptake

    NASA Astrophysics Data System (ADS)

    Schöttler, S.; Klein, Katja; Landfester, K.; Mailänder, V.

    2016-03-01

    Protein adsorption on nanoparticles has been a focus of the field of nanocarrier research in the past few years and more and more papers are dealing with increasingly detailed lists of proteins adsorbed to a plethora of nanocarriers. While there is an urgent need to understand the influence of this protein corona on nanocarriers' interactions with cells the strong impact of the protein source on corona formation and the consequence for interaction with different cell types are factors that are regularly neglected, but should be taken into account for a meaningful analysis. In this study, the importance of the choice of protein source used for in vitro protein corona analysis is concisely investigated. Major and decisive differences in cellular uptake of a polystyrene nanoparticle incubated in fetal bovine serum, human serum, human citrate and heparin plasma are reported. Furthermore, the protein compositions are determined for coronas formed in the respective incubation media. A strong influence of heparin, which is used as an anticoagulant for plasma generation, on cell interaction is demonstrated. While heparin enhances the uptake into macrophages, it prevents internalization into HeLa cells. Taken together we can give the recommendation that human plasma anticoagulated with citrate seems to give the most relevant results for in vitro studies of nanoparticle uptake.Protein adsorption on nanoparticles has been a focus of the field of nanocarrier research in the past few years and more and more papers are dealing with increasingly detailed lists of proteins adsorbed to a plethora of nanocarriers. While there is an urgent need to understand the influence of this protein corona on nanocarriers' interactions with cells the strong impact of the protein source on corona formation and the consequence for interaction with different cell types are factors that are regularly neglected, but should be taken into account for a meaningful analysis. In this study, the importance

  3. Confirmed assignments of isomeric dimethylbenzyl radicals generated by corona discharge.

    PubMed

    Yoon, Young Wook; Lee, Sang Kuk

    2011-12-07

    The controversial vibronic assignments of isomeric dimethylbenzyl radicals were clearly resolved by using different precursors. By employing corresponding dimethylbenzyl chlorides as precursors, we identified the origins of the vibronic bands of the dimethylbenzyl radicals generated by corona discharge of 1,2,4-trimethylbenzene. From the analysis of the spectra observed from the dimethylbenzyl chlorides in a corona excited supersonic expansion, we revised previous assignments of the 3,4-, 2,4-, and 2,5-dimethylbenzyl radicals. Spectroscopic data of electronic transition and vibrational mode frequencies in the ground electronic state of each isomer were accurately determined by comparing them with those obtained by an ab initio calculation and with the known vibrational data of 1,2,4-trimethylbenzene. © 2011 American Institute of Physics

  4. Protein corona formation in bronchoalveolar fluid enhances diesel exhaust nanoparticle uptake and pro-inflammatory responses in macrophages.

    PubMed

    Shaw, Catherine A; Mortimer, Gysell M; Deng, Zhou J; Carter, Edwin S; Connell, Shea P; Miller, Mark R; Duffin, Rodger; Newby, David E; Hadoke, Patrick W F; Minchin, Rodney F

    2016-09-01

    In biological fluids nanoparticles bind a range of molecules, particularly proteins, on their surface. The resulting protein corona influences biological activity and fate of nanoparticle in vivo. Corona composition is often determined by the biological milieu encountered at the entry portal into the body, and, can therefore, depend on the route of exposure to the nanoparticle. For environmental nanoparticles where exposure is by inhalation, this will be lung lining fluid. This study examined plasma and bronchoalveolar fluid (BALF) protein binding to engineered and environmental nanoparticles. We hypothesized that protein corona on nanoparticles would influence nanoparticle uptake and subsequent pro-inflammatory biological response in macrophages. All nanoparticles bound plasma and BALF proteins, but the profile of bound proteins varied between nanoparticles. Focusing on diesel exhaust nanoparticles (DENP), we identified proteins bound from plasma to include fibrinogen, and those bound from BALF to include albumin and surfactant proteins A and D. The presence on DENP of a plasma-derived corona or one of purified fibrinogen failed to evoke an inflammatory response in macrophages. However, coronae formed in BALF increased DENP uptake into macrophages two fold, and increased nanoparticulate carbon black (NanoCB) uptake fivefold. Furthermore, a BALF-derived corona increased IL-8 release from macrophages in response to DENP from 1720 ± 850 pg/mL to 5560 ± 1380 pg/mL (p = 0.014). These results demonstrate that the unique protein corona formed on nanoparticles plays an important role in determining biological reactivity and fate of nanoparticle in vivo. Importantly, these findings have implications for the mechanism of detrimental properties of environmental nanoparticles since the principle route of exposure to such particles is via the lung.

  5. Evaluating the Uncertainties in the Electron Temperature and Radial Speed Measurements Using White Light Corona Eclipse Observations

    NASA Technical Reports Server (NTRS)

    Reginald, Nelson L.; Davilla, Joseph M.; St. Cyr, O. C.; Rastaetter, Lutz

    2014-01-01

    We examine the uncertainties in two plasma parameters from their true values in a simulated asymmetric corona. We use the Corona Heliosphere (CORHEL) and Magnetohydrodynamics Around the Sphere (MAS) models in the Community Coordinated Modeling Center (CCMC) to investigate the differences between an assumed symmetric corona and a more realistic, asymmetric one. We were able to predict the electron temperatures and electron bulk flow speeds to within +/-0.5 MK and +/-100 km s(exp-1), respectively, over coronal heights up to 5.0 R from Sun center.We believe that this technique could be incorporated in next-generation white-light coronagraphs to determine these electron plasma parameters in the low solar corona. We have conducted experiments in the past during total solar eclipses to measure the thermal electron temperature and the electron bulk flow speed in the radial direction in the low solar corona. These measurements were made at different altitudes and latitudes in the low solar corona by measuring the shape of the K-coronal spectra between 350 nm and 450 nm and two brightness ratios through filters centered at 385.0 nm/410.0 nm and 398.7 nm/423.3 nm with a bandwidth of is approximately equal to 4 nm. Based on symmetric coronal models used for these measurements, the two measured plasma parameters were expected to represent those values at the points where the lines of sight intersected the plane of the solar limb.

  6. Improvement in ionization efficiency of direct analysis in real time-mass spectrometry (DART-MS) by corona discharge.

    PubMed

    Sekimoto, Kanako; Sakakura, Motoshi; Kawamukai, Takatomo; Hike, Hiroshi; Shiota, Teruhisa; Usui, Fumihiko; Bando, Yasuhiko; Takayama, Mitsuo

    2016-08-02

    Herein it is shown that a combination of direct analysis in real time (DART) with a corona discharge system consisting of only a needle electrode easily improves DART ionization efficiency. Positive and negative DC corona discharges led to a formation of abundant excited helium atoms as well as the reactant ions H3O(+)(H2O)n and O2˙(-) in the DART analyte ionization area. These phenomena resulted in an increase in the absolute intensities of (de)protonated analytes by a factor of 2-20 over conventional DART. The other analyte ions detected in this corona-DART system (i.e., molecular ions, fragment ions, oxygenated (de)protonated analytes, dehydrogenated deprotonated analytes, and negative ion adducts) were quite similar to those obtained from DART alone. This indicates a lack of side reactions due to the corona discharge. The change in the relative intensities of individual analyte-related ions due to the combination of a corona discharge system with DART suggests that there is no effect of the abundant excited helium in the analyte ionization area on the fragmentation processes or enhancement of oxidation due to hydroxyl radicals HO˙. Furthermore, it was found that the corona-DART combination can be applied to the highly sensitive analysis of n-alkanes, in which the alkanes are ionized as positive ions via hydride abstraction and oxidation, independent of the type of alkane or the mass spectrometer used.

  7. Incremental social learning in particle swarms.

    PubMed

    de Oca, Marco A Montes; Stutzle, Thomas; Van den Enden, Ken; Dorigo, Marco

    2011-04-01

    Incremental social learning (ISL) was proposed as a way to improve the scalability of systems composed of multiple learning agents. In this paper, we show that ISL can be very useful to improve the performance of population-based optimization algorithms. Our study focuses on two particle swarm optimization (PSO) algorithms: a) the incremental particle swarm optimizer (IPSO), which is a PSO algorithm with a growing population size in which the initial position of new particles is biased toward the best-so-far solution, and b) the incremental particle swarm optimizer with local search (IPSOLS), in which solutions are further improved through a local search procedure. We first derive analytically the probability density function induced by the proposed initialization rule applied to new particles. Then, we compare the performance of IPSO and IPSOLS on a set of benchmark functions with that of other PSO algorithms (with and without local search) and a random restart local search algorithm. Finally, we measure the benefits of using incremental social learning on PSO algorithms by running IPSO and IPSOLS on problems with different fitness distance correlations.

  8. NUMERICAL SIMULATION OF THREE-DIMENSIONAL TUFT CORONA AND ELECTROHYDRODYNAMICS

    EPA Science Inventory

    The numerical simulation of three-dimensional tuft corona and electrohydrodynamics (EHD) is discussed. The importance of high-voltage and low-current operation in the wire-duct precipitator has focused attention on collecting high-resistivity dust. The local current density of in...

  9. Protein Corona Formation on Colloidal Polymeric Nanoparticles and Polymeric Nanogels: Impact on Cellular Uptake, Toxicity, Immunogenicity, and Drug Release Properties.

    PubMed

    Obst, Katja; Yealland, Guy; Balzus, Benjamin; Miceli, Enrico; Dimde, Mathias; Weise, Christoph; Eravci, Murat; Bodmeier, Roland; Haag, Rainer; Calderón, Marcelo; Charbaji, Nada; Hedtrich, Sarah

    2017-06-12

    The adsorption of biomolecules to the surface of nanoparticles (NPs) following administration into biological environments is widely recognized. In particular, the "protein corona" is well understood in terms of formation kinetics and impact upon the biological interactions of NPs. Its presence is an essential consideration in the design of therapeutic NPs. In the present study, the protein coronas of six polymeric nanoparticles of prospective therapeutic use were investigated. These included three colloidal NPs-soft core-multishell (CMS) NPs, plus solid cationic Eudragit RS (EGRS), and anionic ethyl cellulose (EC) nanoparticles-and three nanogels (NGs)-thermoresponsive dendritic-polyglycerol (dPG) nanogels (NGs) and two amino-functionalized dPG-NGs. Following incubation with human plasma, protein coronas were characterized and their biological interactions compared with pristine NPs. All NPs demonstrated protein adsorption and increased hydrodynamic diameters, although the solid EGRS and EC NPs bound notably more protein than the other tested particles. Shifts toward moderately negative surface charges were also observed for all corona bearing NPs, despite varied zeta potentials in their pristine states. While the uptake and cellular adhesion of the colloidal NPs in primary human keratinocytes and human umbilical vein endothelial cells were significantly decreased when bearing the protein corona, no obvious impact was seen in the NGs. By contrast, corona bearing NGs induced marked increases in cytokine release from primary human macrophages not seen with corona bearing colloidal NPs. Despite this, no apparent enhancement to in vitro toxicity was noted. Finally, drug release from EGRS and EC NPs was assessed, where a decrease was seen in the EGRS NPs alone. Together these results provide a direct comparison of the physical and biological impact the protein corona has on NPs of widely varied character and in particular highlights a distinction between the corona

  10. Failure? Isn't It Time to Slay the Design-Dragon?

    ERIC Educational Resources Information Center

    Winkler, Dietmar R.

    2009-01-01

    There is a closed cycle of design education that replicates the most common design practice--and feeds into that practice that seeks awards based on incremental change supported by professional organizations and trade journals--that feeds back to education forms for imitation. This is the educational failure this paper cites. It takes to task the…

  11. The use of subjective expert opinions in cost optimum design of aerospace structures. [probabilistic failure models

    NASA Technical Reports Server (NTRS)

    Thomas, J. M.; Hanagud, S.

    1975-01-01

    The results of two questionnaires sent to engineering experts are statistically analyzed and compared with objective data from Saturn V design and testing. Engineers were asked how likely it was for structural failure to occur at load increments above and below analysts' stress limit predictions. They were requested to estimate the relative probabilities of different failure causes, and of failure at each load increment given a specific cause. Three mathematical models are constructed based on the experts' assessment of causes. The experts' overall assessment of prediction strength fits the Saturn V data better than the models do, but a model test option (T-3) based on the overall assessment gives more design change likelihood to overstrength structures than does an older standard test option. T-3 compares unfavorably with the standard option in a cost optimum structural design problem. The report reflects a need for subjective data when objective data are unavailable.

  12. Structure and Dynamics of the 2009 July 22 Eclipse White-light Corona

    NASA Astrophysics Data System (ADS)

    Pasachoff, J. M.; Rušin, V.; Saniga, M.; Druckmüllerová, H.; Babcock, B. A.

    2011-11-01

    The white-light corona (WLC) during the total solar eclipse of 2009 July 22 was observed by several teams in the Moon's shadow stretching from India and China across the Pacific Ocean with its many isolated islands. We present a comparison of the WLC as observed by eclipse teams located in China (Shanghai region) and on the Enewetak Atoll in the Marshall Islands, with observations taken 112 minutes apart, combined with near-simultaneous space observations. The eclipse was observed at the beginning of solar cycle 24, during a deep solar minimum (officially estimated as 2008 December according to the smoothed sunspot number, but very extended). The solar corona shows several different types of features (coronal holes, polar rays, helmet streamers, faint loops, voids, etc.), though it was extremely sparse in streamers as shown from Large-Angle Spectroscopic Coronagraph data. No large-scale dynamical phenomena were seen when comparing the observations from the two sites, confirming that the corona was quiescent. We measure a Ludendorff flattening coefficient of 0.238, typical of solar minimum.

  13. Decomposition Characteristics of Acetone in a DC Corona Discharge at Atmospheric Pressure

    NASA Astrophysics Data System (ADS)

    Sakamoto, Takahiro; Satoh, Kohki; Itoh, Hidenori

    Decomposition characteristics of acetone in a DC corona discharge generated between a multi-needle and a plane electrodes in nitrogen-oxygen mixtures at atmospheric pressure are investigated mainly by infrared absorption spectroscopy in this work. It is found that CO2, CO, CH4, HCHO, HCOOH and HCN are the by-products of acetone in the corona discharge, and that CO, CH4, HCHO, HCOOH and HCN are intermediate products, which tend to be decomposed in the corona discharge. CO2 is found to be the major and end-product. It is also found that acetone is chiefly inverted to CO2 via CO at high oxygen concentration (20%) and via CO and CH4 at relatively low oxygen concentration (0.2%), in addition to the direct conversion from acetone to CO2. As the oxygen concentration increases, the percentages of carbon atoms contained in deposit on the plane electrode and the wall of the discharge chamber increases. Further, the decomposition process of acetone is deduced from the examination of rate constants for the reactions in the gaseous phase.

  14. IgA and IgM protein primarily drive plasma corona-induced adhesion reduction of PLGA nanoparticles in human blood flow.

    PubMed

    Sobczynski, Daniel J; Eniola-Adefeso, Omolola

    2017-06-01

    The high abundance of immunoglobulins (Igs) in the plasma protein corona on poly(lactic-co-glycolic) acid (PLGA)-based vascular-targeted carriers (VTCs) has previously been shown to reduce their adhesion to activated endothelial cells (aECs) in human blood flow. However, the relative role of individual Ig classes (e.g., IgG, IgA, and IgM) in causing adhesion reduction remains largely unknown. Here, we characterized the influence of specific Ig classes in prescribing the binding efficiency of PLGA nano-sized VTCs in blood flow. Specifically, we evaluated the flow adhesion to aECs of PLGA VTCs with systematic depletion of various Igs in their corona. Adhesion reduction was largely eliminated for PLGA VTCs when all Igs were removed from the corona. Furthermore, re-addition of IgA or IgM to the Igs-depleted corona reinstated the low adhesion of PLGA VTCs, as evidenced by ∼40-70% reduction relative to particles with an Igs-deficient corona. However, re-addition of a high concentration of IgG to the Igs-depleted corona did not cause significant adhesion reduction. Overall, the presented results reveal that PLGA VTC adhesion reduction in blood flows is primarily driven by high adsorption of IgA and IgM in the particle corona. Pre-coating of albumin on PLGA VTCs mitigated the extent of adhesion reduction in plasma for some donors but was largely ineffective in general. Overall, this work may shed light into effective control of protein corona composition, thereby enhancing VTC functionality in vivo for eventual clinical use.

  15. Emergence of magnetic flux from the convection zone into the corona

    NASA Astrophysics Data System (ADS)

    Archontis, V.; Moreno-Insertis, F.; Galsgaard, K.; Hood, A.; O'Shea, E.

    2004-11-01

    Numerical experiments of the emergence of magnetic flux from the uppermost layers of the solar interior to the photosphere and its further eruption into the low atmosphere and corona are carried out. We use idealized models for the initial stratification and magnetic field distribution below the photosphere similar to those used for multidimensional flux emergence experiments in the literature. The energy equation is adiabatic except for the inclusion of ohmic and viscous dissipation terms, which, however, become important only at interfaces and reconnection sites. Three-dimensional experiments for the eruption of magnetic flux both into an unmagnetized corona and into a corona with a preexisting ambient horizontal field are presented. The shocks preceding the rising plasma present the classical structure of nonlinear Lamb waves. The expansion of the matter when rising into the atmosphere takes place preferentially in the horizontal directions: a flattened (or oval) low plasma-β ball ensues, in which the field lines describe loops in the corona with increasing inclination away from the vertical as one goes toward the sides of the structure. Magnetograms and velocity field distributions on horizontal planes are presented simultaneously for the solar interior and various levels in the atmosphere. Since the background pressure and density drop over many orders of magnitude with increasing height, the adiabatic expansion of the rising plasma yields very low temperatures. To avoid this, the entropy of the rising fluid elements should be increased to the high values of the original atmosphere via heating mechanisms not included in the present numerical experiments. The eruption of magnetic flux into a corona with a preexisting magnetic field pointing in the horizontal direction yields a clear case of essentially three-dimensional reconnection when the upcoming and ambient field systems come into contact. The coronal ambient field is chosen at time t=0 perpendicular to

  16. Ground-based observations of the corona in the visible and NIR spectral ranges

    NASA Technical Reports Server (NTRS)

    Epple, Alexander; Schwenn, Rainer

    1995-01-01

    Since late 1993 we have been using a mirror coronagraph on Pic du Midi (PICO) to observe the solar emission corona in several spectral lines of (FE-X), (FE-XIII), and (FE-XIV). For good meteorological conditions the diffuse corona and coronal holes in between can be seen out to 1.2 solar mass for sun center. Active regions can be mapped to bond 1.5 solar mass in the green and infrared lines. Recent observations of PICO are presented.

  17. Report on New Mission Concept Study: Stereo X-Ray Corona Imager Mission

    NASA Technical Reports Server (NTRS)

    Liewer, Paulett C.; Davis, John M.; DeJong, E. M.; Gary, G. Allen; Klimchuk, James A.; Reinert, R. P.

    1998-01-01

    Studies of the three-dimensional structure and dynamics of the solar corona have been severely limited by the constraint of single viewpoint observations. The Stereo X-Ray Coronal Imager (SXCI) mission will send a single instrument, an X-ray telescope, into deep space expressly to record stereoscopic images of the solar corona. The SXCI spacecraft will be inserted into a approximately 1 AU heliocentric orbit leading Earth by approximately 25 deg at the end of nine months. The SXCI X-ray telescope forms one element of a stereo pair, the second element being an identical X-ray telescope in Earth orbit placed there as part of the NOAA GOES program. X-ray emission is a powerful diagnostic of the corona and its magnetic fields, and three dimensional information on the coronal magnetic structure would be obtained by combining the data from the two X-ray telescopes. This information can be used to address the major solar physics questions of (1) what causes explosive coronal events such as coronal mass ejections (CMEs), eruptive flares and prominence eruptions and (2) what causes the transient heating of coronal loops. Stereoscopic views of the optically thin corona will resolve some ambiguities inherent in single line-of-sight observations. Triangulation gives 3D solar coordinates of features which can be seen in the simultaneous images from both telescopes. As part of this study, tools were developed for determining the 3D geometry of coronal features using triangulation. Advanced technologies for visualization and analysis of stereo images were tested. Results of mission and spacecraft studies are also reported.

  18. Mass-Loss Evolution in the EUV Low Corona from SDO/AIA Data

    NASA Astrophysics Data System (ADS)

    López, Fernando M.; Hebe Cremades, M.; Nuevo, Federico A.; Balmaceda, Laura A.; Vásquez, Alberto M.

    2017-01-01

    We carry out an analysis of the mass that is ejected from three coronal dimming regions observed by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory. The three events are unambiguously identified with white-light coronal mass ejections (CMEs) that are associated in turn with surface activity of diverse nature: an impulsive (M-class) flare, a weak (B-class) flare, and a filament eruption without a flare. The use of three AIA coronal passbands allows applying a differential emission measure technique to define the dimming regions and identify their ejected mass through the analysis of the electronic density depletion associated with the eruptions. The temporal evolution of the mass loss from the three dimmings can be approximated by an exponential equation followed by a linear fit. We determine the mass of the associated CMEs from COR2 data. The results show that the ejected masses from the low corona represent a considerable amount of the CME mass. We also find that plasma is still being ejected from the low corona at the time when the CMEs reach the COR2 field of view. The temporal evolution of the angular width of the CMEs, of the dimming regions in the low corona, and of the flux registered by GOES in soft X-rays are all in close relation with the behavior of mass ejection from the low corona. We discuss the implications of our findings toward a better understanding of the temporal evolution of several parameters associated with the analyzed dimmings and CMEs.

  19. The CORONAS-Photon/TESIS experiment on EUV imaging spectroscopy of the Sun

    NASA Astrophysics Data System (ADS)

    Kuzin, S.; Zhitnik, I.; Bogachev, S.; Bugaenko, O.; Ignat'ev, A.; Mitrofanov, A.; Perzov, A.; Shestov, S.; Slemzin, V.; Suhodrev, N.

    The new experiment TESIS is developent for russian CORONAS-Photon mission launch is planned on the end of 2007 The experiment is aimed on the study of activity of the Sun in the phases of minimum rise and maximum of 24 th cycle of Solar activity by the method of XUV imaging spectroscopy The method is based on the registration full-Sun monochromatic images with high spatial and temporal resolution The scientific tasks of the experiment are i Investigation dynamic processes in corona flares CME etc with high spatial up to 1 and temporal up to 1 second resolution ii determination of the main plasma parameters like plasma electron and ion density and temperature differential emission measure etc iii study of the processes of appearance and development large scale long-life magnetic structures in the solar corona study of the fluency of this structures on the global activity of the corona iv study of the mechanisms of energy accumulation and release in the solar flares and mechanisms of transformation of this energy into the heating of the plasma and kinematics energy To get the information for this studies the TESIS will register full-Sun images in narrow spectral intervals and the monochromatic lines of HeII SiXI FeXXI-FeXXIII MgXII ions The instrument includes 5 independent channels 2 telescopes for 304 and 132 A wide-field 2 5 degrees coronograph 280-330A and 8 42 A spectroheliographs The detailed description of the TESIS experiment and the instrument is presented

  20. An atlas of soft X-ray images of the solar corona from Skylab

    NASA Technical Reports Server (NTRS)

    Zombeck, M. V.; Vaiana, G. S.; Haggerty, R.; Krieger, A. S.; Silk, J. K.; Timothy, A.

    1978-01-01

    An atlas is presented which contains daily full-sun photographs of the soft X-ray solar corona taken in two filters with an X-ray telescope on the Apollo telescope mount of Skylab for the period from May 29 to November 27, 1973. The passband of the first filter covers the wavelength regions from 2 to 32 A and 44 to 54 A; the second filter covers the region from 2 to 17 A. Characteristics of the instrument, the wavelength response, and sensitivity are described along with the total data base, of which the atlas represents only 1%. Comparisons are made with observations of the white-light corona, photospheric magnetic field, H-alpha radiation from the chromosphere, and 284-A Fe XV emission from the corona. A complete bibliography of scientific papers that have used the data base and a bibliography of catalogs and atlases containing related data for the same observational period are provided.

  1. Protein corona as a proteome fingerprint: The example of hidden biomarkers for cow mastitis.

    PubMed

    Miotto, Giovanni; Magro, Massimiliano; Terzo, Milo; Zaccarin, Mattia; Da Dalt, Laura; Bonaiuto, Emanuela; Baratella, Davide; Gabai, Gianfranco; Vianello, Fabio

    2016-04-01

    Proteome modifications in a biological fluid can potentially indicate the occurrence of pathologies, even if the identification of a proteome fingerprint correlated to a specific disease represents a very difficult task. When a nanomaterial is introduced into a biological fluid, macromolecules compete to form a protein corona on the nanoparticle surface, and depending on the specific proteome, different patterns of proteins will form the final protein corona shell depending on their affinity for the nanoparticle surface. Novel surface active maghemite nanoparticles (SAMNs) display a remarkable selectivity toward protein corona formation, and they are able to concentrate proteins and peptides presenting high affinities for their surface even if they are present in very low amounts. Thus, SAMNs may confer visibility to hidden biomarkers correlated to the occurrence of a pathology. In the present report, SAMNs were introduced into milk samples from healthy cows and from animals affected by mastitis, and the selectively bound protein corona shell was easily analyzed and quantified by gel electrophoresis and characterized by mass spectrometry. Upon incubation in mastitic milk, SAMNs were able to selectively bind αs2-casein fragments containing the FALPQYLK sequence, as part of the larger casocidin-1 peptide with strong antibacterial activity, which were not present in healthy samples. Thus, SAMNs can be used as a future candidate for the rapid diagnosis of mastitis in bovine milk. The present report proposes protein competition for SAMN protein corona formation as a means of mirroring proteome modifications. Thus, the selected protein shell on the nanoparticles results in a fingerprint of the specific pathology. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Revealing structure and evolution within the corona of the Seyfert galaxy I Zw 1

    NASA Astrophysics Data System (ADS)

    Wilkins, D. R.; Gallo, L. C.; Silva, C. V.; Costantini, E.; Brandt, W. N.; Kriss, G. A.

    2017-11-01

    X-ray spectral timing analysis is presented of XMM-Newton observations of the narrow-line Seyfert 1 galaxy I Zwicky 1 taken in 2015 January. After exploring the effect of background flaring on timing analyses, X-ray time lags between the reflection-dominated 0.3-1.0 keV energy and continuum-dominated 1.0-4.0 keV band are measured, indicative of reverberation off the inner accretion disc. The reverberation lag time is seen to vary as a step function in frequency; across lower frequency components of the variability, 3 × 10-4-1.2 × 10-3 Hz a lag of 160 s is measured, but the lag shortens to (59 ± 4) s above 1.2 × 10-3 Hz. The lag-energy spectrum reveals differing profiles between these ranges with a change in the dip showing the earliest arriving photons. The low-frequency signal indicates reverberation of X-rays emitted from a corona extended at low height over the disc, while at high frequencies, variability is generated in a collimated core of the corona through which luminosity fluctuations propagate upwards. Principal component analysis of the variability supports this interpretation, showing uncorrelated variation in the spectral slope of two power-law continuum components. The distinct evolution of the two components of the corona is seen as a flare passes inwards from the extended to the collimated portion. An increase in variability in the extended corona was found preceding the initial increase in X-ray flux. Variability from the extended corona was seen to die away as the flare passed into the collimated core leading to a second sharper increase in the X-ray count rate.

  3. Air trichloroethylene oxidation in a corona plasma-catalytic reactor

    NASA Astrophysics Data System (ADS)

    Masoomi-Godarzi, S.; Ranji-Burachaloo, H.; Khodadadi, A. A.; Vesali-Naseh, M.; Mortazavi, Y.

    2014-08-01

    The oxidative decomposition of trichloroethylene (TCE; 300 ppm) by non-thermal corona plasma was investigated in dry air at atmospheric pressure and room temperature, both in the absence and presence of catalysts including MnOx, CoOx. The catalysts were synthesized by a co-precipitation method. The morphology and structure of the catalysts were characterized by BET surface area measurement and Fourier Transform Infrared (FTIR) methods. Decomposition of TCE and distribution of products were evaluated by a gas chromatograph (GC) and an FTIR. In the absence of the catalyst, TCE removal is increased with increases in the applied voltage and current intensity. Higher TCE removal and CO2 selectivity is observed in presence of the corona and catalysts, as compared to those with the plasma alone. The results show that MnOx and CoOx catalysts can dissociate the in-plasma produced ozone to oxygen radicals, which enhances the TCE decomposition.

  4. Surveying the IR corona during the 2017 solar eclipse

    NASA Astrophysics Data System (ADS)

    Bryans, P.; Hannigan, J. W.; Sewell, S. D.; Judge, P. G.

    2017-12-01

    The spectral emission of the infrared solar corona is the most promising direct diagnostic of the coronal magnetic field, and yet remains poorly measured. During the 2017 total solar eclipse, we will perform the first spectral survey of the IR corona using the NCAR Airborne Interferometer. This Fourier Transform Infrared Spectrometer is configured to observe the coronal spectrum from 1.5 to 5.5 microns at R 10,000 from a ground-based site. The location is atop Casper Mountain, Wyoming (42.73ºN, 106.32ºW, 2400 masl), 8 km from the center-line of totality. In this presentation, we will outline the need for such measurements, describe the instrument design and adaptation for the eclipse measurement, observation scheme, and present preliminary results. We will also discuss implications for observing infrared coronal lines from the ground, for example with the upcoming DKIST facility.

  5. Tomographic Validation of the AWSoM Model of the Inner Corona During Solar Minima

    NASA Astrophysics Data System (ADS)

    Manchester, W.; Vásquez, A. M.; Lloveras, D. G.; Mac Cormack, C.; Nuevo, F.; Lopez-Fuentes, M.; Frazin, R. A.; van der Holst, B.; Landi, E.; Gombosi, T. I.

    2017-12-01

    Continuous improvement of MHD three-dimensional (3D) models of the global solar corona, such as the Alfven Wave Solar Model (AWSoM) of the Space Weather Modeling Framework (SWMF), requires testing their ability to reproduce observational constraints at a global scale. To that end, solar rotational tomography based on EUV image time-series can be used to reconstruct the 3D distribution of the electron density and temperature in the inner solar corona (r < 1.25 Rsun). The tomographic results, combined with a global coronal magnetic model, can further provide constraints on the energy input flux required at the coronal base to maintain stable structures. In this work, tomographic reconstructions are used to validate steady-state 3D MHD simulations of the inner corona using the latest version of the AWSoM model. We perform the study for selected rotations representative of solar minimum conditions, when the global structure of the corona is more axisymmetric. We analyse in particular the ability of the MHD simulation to match the tomographic results across the boundary region between the equatorial streamer belt and the surrounding coronal holes. The region is of particular interest as the plasma flow from that zone is thought to be related to the origin of the slow component of the solar wind.

  6. LASCO Observations Of The K-Corona From Solar Minimum To Solar Maximum And Beyond

    NASA Astrophysics Data System (ADS)

    Andrews, Michael D.; Howard, Russell A.

    2003-09-01

    The LASCO C2 and C3 coronagraphs on SOHO have been recording a regular series of images of the corona since May 1996. This sequence of data covers the period of solar minimum, the increase to solar maximum, and the beginning of the decline toward the next solar minimum. The images have been analyzed to determine the brightness of the K-corona (solar photons Thomson scattered from free electrons). The total brightness of the K-corona is approximately constant from May 1996 through May 1997. The brightness is then seen to increase steadily until early in the year 2000. The structure of the K-corona changes dramatically with solar cycle. The shape as seen in C2 becomes almost circular at solar maximum while the C3 images continue to show equatorial streamers. The magnitude of the solar cycle variation decreases as the height increases. We present data animations (movies) to show the large-scale structure. We have inverted 28-day averages of the white light images to determine radial profiles of electron density. We present these electron profiles, show how they vary as a function of both latitude and time, and compare our observed profiles with other models and observations.

  7. Incremental passivity and output regulation for switched nonlinear systems

    NASA Astrophysics Data System (ADS)

    Pang, Hongbo; Zhao, Jun

    2017-10-01

    This paper studies incremental passivity and global output regulation for switched nonlinear systems, whose subsystems are not required to be incrementally passive. A concept of incremental passivity for switched systems is put forward. First, a switched system is rendered incrementally passive by the design of a state-dependent switching law. Second, the feedback incremental passification is achieved by the design of a state-dependent switching law and a set of state feedback controllers. Finally, we show that once the incremental passivity for switched nonlinear systems is assured, the output regulation problem is solved by the design of global nonlinear regulator controllers comprising two components: the steady-state control and the linear output feedback stabilising controllers, even though the problem for none of subsystems is solvable. Two examples are presented to illustrate the effectiveness of the proposed approach.

  8. Stellar winds and coronae of low-mass Population II/III stars

    NASA Astrophysics Data System (ADS)

    Suzuki, Takeru K.

    2018-06-01

    We investigated stellar winds from zero-/low-metallicity low-mass stars by magnetohydrodynamical simulations for stellar winds driven by Alfvén waves from stars with mass M = (0.6-0.8) M⊙ and metallicity Z = (0-1) Z⊙, where M⊙ and Z⊙ are the solar mass and metallicity, respectively. Alfvénic waves, which are excited by the surface convection, travel upward from the photosphere and heat up the corona by their dissipation. For lower Z, denser gas can be heated up to the coronal temperature because of the inefficient radiation cooling. The coronal density of Population II/III stars with Z ≤ 0.01 Z⊙ is one to two orders of magnitude larger than that of a solar-metallicity star with the same mass, and as a result, the mass loss rate, \\dot{M}, is 4.5-20 times larger. This indicates that metal accretion on low-mass Pop. III stars is negligible. The soft X-ray flux of the Pop. II/III stars is also expected to be ˜1-30 times larger than that of a solar-metallicity counterpart owing to the larger coronal density, even though the radiation cooling efficiency is smaller. A larger fraction of the input Alfvénic wave energy is transmitted to the corona in low-Z stars because they avoid severe reflection owing to the smaller density difference between the photosphere and the corona. Therefore, a larger fraction is converted to the thermal energy of the corona and the kinetic energy of the stellar wind. From this energetics argument, we finally derived a scaling of \\dot{M} as \\dot{M}∝ L R_{\\star }^{11/9} M_{\\star }^{-10/9} T_eff^{11/2}[\\max (Z/Z_{⊙},0.01)]^{-1/5}, where L, R⋆, and Teff are the stellar luminosity, radius, and effective temperature, respectively.

  9. Stellar winds and coronae of low-mass Population II/III stars

    NASA Astrophysics Data System (ADS)

    Suzuki, Takeru K.

    2018-04-01

    We investigated stellar winds from zero-/low-metallicity low-mass stars by magnetohydrodynamical simulations for stellar winds driven by Alfvén waves from stars with mass M = (0.6-0.8) M⊙ and metallicity Z = (0-1) Z⊙, where M⊙ and Z⊙ are the solar mass and metallicity, respectively. Alfvénic waves, which are excited by the surface convection, travel upward from the photosphere and heat up the corona by their dissipation. For lower Z, denser gas can be heated up to the coronal temperature because of the inefficient radiation cooling. The coronal density of Population II/III stars with Z ≤ 0.01 Z⊙ is one to two orders of magnitude larger than that of a solar-metallicity star with the same mass, and as a result, the mass loss rate, \\dot{M}, is 4.5-20 times larger. This indicates that metal accretion on low-mass Pop. III stars is negligible. The soft X-ray flux of the Pop. II/III stars is also expected to be ˜1-30 times larger than that of a solar-metallicity counterpart owing to the larger coronal density, even though the radiation cooling efficiency is smaller. A larger fraction of the input Alfvénic wave energy is transmitted to the corona in low-Z stars because they avoid severe reflection owing to the smaller density difference between the photosphere and the corona. Therefore, a larger fraction is converted to the thermal energy of the corona and the kinetic energy of the stellar wind. From this energetics argument, we finally derived a scaling of \\dot{M} as \\dot{M}∝ L R_{\\star }^{11/9} M_{\\star }^{-10/9} T_eff^{11/2}[\\max (Z/Z_{⊙},0.01)]^{-1/5}, where L, R⋆, and Teff are the stellar luminosity, radius, and effective temperature, respectively.

  10. Numerical Simulations of Helicity Condensation in the Solar Corona

    NASA Technical Reports Server (NTRS)

    Zhao, L.; DeVore, C. R.; Antiochos, S. K.; Zurbuchen, T. H.

    2015-01-01

    The helicity condensation model has been proposed by Antiochos (2013) to explain the observed smoothness of coronal loops and the observed buildup of magnetic shear at filament channels. The basic hypothesis of the model is that magnetic reconnection in the corona causes the magnetic stress injected by photospheric motions to collect only at those special locations where prominences form. In this work we present the first detailed quantitative MHD simulations of the reconnection evolution proposed by the helicity condensation model. We use the well-known ansatz of modeling the closed corona as an initially uniform field between two horizontal photospheric plates. The system is driven by applying photospheric rotational flows that inject magnetic helicity into the system. The flows are confined to a finite region on the photosphere so as to mimic the finite flux system of, for example, a bipolar active region. The calculations demonstrate that, contrary to common belief, coronal loops having opposite helicity do not reconnect, whereas loops having the same sense of helicity do reconnect. Furthermore, we find that for a given amount of helicity injected into the corona, the evolution of the magnetic shear is insensitive to whether the pattern of driving photospheric motions is fixed or quasi-random. In all cases, the shear propagates via reconnection to the boundary of the flow region while the total magnetic helicity is conserved, as predicted by the model. We discuss the implications of our results for solar observations and for future, more realistic simulations of the helicity condensation process.

  11. High frequency generation in the corona: Resonant cavities

    NASA Astrophysics Data System (ADS)

    Santamaria, I. C.; Van Doorsselaere, T.

    2018-03-01

    Aims: Null points are prominent magnetic field singularities in which the magnetic field strength strongly decreases in very small spatial scales. Around null points, predicted to be ubiquitous in the solar chromosphere and corona, the wave behavior changes considerably. Null points are also responsible for driving very energetic phenomena, and for contributing to chromospheric and coronal heating. In previous works we demonstrated that slow magneto-acoustic shock waves were generated in the chromosphere propagate through the null point, thereby producing a train of secondary shocks escaping along the field lines. A particular combination of the shock wave speeds generates waves at a frequency of 80 MHz. The present work aims to investigate this high frequency region around a coronal null point to give a plausible explanation to its generation at that particular frequency. Methods: We carried out a set of two-dimensional numerical simulations of wave propagation in the neighborhood of a null point located in the corona. We varied both the amplitude of the driver and the atmospheric properties to investigate the sensitivity of the high frequency waves to these parameters. Results: We demonstrate that the wave frequency is sensitive to the atmospheric parameters in the corona, but it is independent of the strength of the driver. Thus, the null point behaves as a resonant cavity generating waves at specific frequencies that depend on the background equilibrium model. Moreover, we conclude that the high frequency wave train generated at the null point is not necessarily a result of the interaction between the null point and a shock wave. This wave train can be also developed by the interaction between the null point and fast acoustic-like magneto-acoustic waves, that is, this interaction within the linear regime.

  12. Detailed characteristics of intermittent current pulses due to positive corona

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Yang, E-mail: liuyangwuh520@sina.com; Cui, Xiang; Lu, Tiebing

    In order to get detailed characteristics of intermittent current pulses due to positive corona such as the repetition rate of burst-pulse trains, the peak value ratio of the primary pulse to the secondary pulse, the number of pulses per burst, and the interval of the secondary pulses, a systematic study was carried out in a coaxial conductor-cylinder electrode system with the conductor electrode being set with a discharge point. Empirical formulae for the number of pulses per burst and the interval of the secondary pulses are first presented. A theoretical model based on the motion of the space-charge clouds ismore » proposed. Analysis with the model gives explanations to the experimental results and reveals some new insights into the physical mechanism of positive intermittent corona.« less

  13. Corona discharge detection based on UV pulse method

    NASA Astrophysics Data System (ADS)

    Zhao, Taifei; Lei, Yangfei; Hou, Peng

    2016-03-01

    With the reforming and opening up, as well as the rapid economic development of china, the shortage of electricity resources in the eastern region has become a problem. Therefore, we have started the program of power transmission from west to east, and have speeding up the development of high-voltage transmission technologies with high efficiency, long-distance, and high-capacity. An important issue during the power transmission is the insulation design. Recently, there have been more and more power grid accidents are escalating. Therefore, timely discovering an forecasting insulation deteriorations using advance detection techniques is of special practical significance for the equipment maintenance and repairing , and especially avoiding power accidents. On this basis, this paper carries out the research of high-voltage transmission line corona discharge detection system using the solar blind and FPGA. The experimental result shows that our system can amplify week signals with different intensity of 5100 5000100 times, with high sensitivity and anti-interference ability. The result also proves that this system can effectively detect the ultraviolet pulse light signal of the corona discharge insulation.

  14. A Corona Discharge Initiated Electrochemical Electrospray Ionization Technique

    PubMed Central

    Lloyd, John R.; Hess, Sonja

    2009-01-01

    We report here the development of a corona discharge (CD) initiated electrochemical (EC) electrospray ionization (ESI) technique using a standard electrospray ion source. This is a new ionization technique distinct from ESI, electrochemistry inherent to ESI, APCI, and techniques using hydroxyl radicals produced under atmospheric pressure conditions. By maximizing the observable CD at the tip of a stainless steel ESI capillary, efficient electrochemical oxidation of electrochemically active compounds is observed. For electrochemical oxidation to be observed, the ionization potential of the analyte must be lower than Fe. Ferrocene labeled compounds were chosen as the electrochemically active moiety. The electrochemical cell in the ESI source was robust and generated ions with selectivity according to the ionization potential of the analytes and up to zeptomolar sensitivity. Our results indicate that CD initiated electrochemical ionization has the potential to become a powerful technique to increase the dynamic range, sensitivity and selectivity of ESI experiments. Synopsis Using a standard ESI source a corona discharge initiated electrochemical ionization technique was established resulting from the electrochemistry occurring at the CD electrode surface. PMID:19747843

  15. The Structure and Dynamics of the Solar Corona and Inner Heliosphere

    NASA Technical Reports Server (NTRS)

    Mikic, Zoran

    2002-01-01

    This report covers technical progress during the second quarter of the first year of NASA Sun-Earth Connections Theory Program (SECTP) contract 'The Structure and Dynamics of the Solar Corona and Inner Heliosphere,' NAS5-99188, between NASA and Science Applications International Corporation. and covers the period November 16, 1999 to February 15, 2000. Under this contract SAIC and the University of California, Irvine (UCI) have conducted research into theoretical modeling of active regions, the solar corona, and the inner heliosphere, using the MHD (magnetohydrodynamic) model. The topics studied include: the effect of emerging flux on the stability of helmet streamers, coronal loops and streamers, the solar magnetic field, the solar wind, and open magnetic field lines.

  16. A new casemix adjustment index for hospital mortality among patients with congestive heart failure.

    PubMed

    Polanczyk, C A; Rohde, L E; Philbin, E A; Di Salvo, T G

    1998-10-01

    Comparative analysis of hospital outcomes requires reliable adjustment for casemix. Although congestive heart failure is one of the most common indications for hospitalization, congestive heart failure casemix adjustment has not been widely studied. The purposes of this study were (1) to describe and validate a new congestive heart failure-specific casemix adjustment index to predict in-hospital mortality and (2) to compare its performance to the Charlson comorbidity index. Data from all 4,608 admissions to the Massachusetts General Hospital from January 1990 to July 1996 with a principal ICD-9-CM discharge diagnosis of congestive heart failure were evaluated. Massachusetts General Hospital patients were randomly divided in a derivation and a validation set. By logistic regression, odds ratios for in-hospital death were computed and weights were assigned to construct a new predictive index in the derivation set. The performance of the index was tested in an internal Massachusetts General Hospital validation set and in a non-Massachusetts General Hospital external validation set incorporating data from all 1995 New York state hospital discharges with a primary discharge diagnosis of congestive heart failure. Overall in-hospital mortality was 6.4%. Based on the new index, patients were assigned to six categories with incrementally increasing hospital mortality rates ranging from 0.5% to 31%. By logistic regression, "c" statistics of the congestive heart failure-specific index (0.83 and 0.78, derivation and validation set) were significantly superior to the Charlson index (0.66). Similar incrementally increasing hospital mortality rates were observed in the New York database with the congestive heart failure-specific index ("c" statistics 0.75). In an administrative database, this congestive heart failure-specific index may be a more adequate casemix adjustment tool to predict hospital mortality in patients hospitalized for congestive heart failure.

  17. Study of the solar corona using radio and space observations

    NASA Technical Reports Server (NTRS)

    Dulk, G. A.

    1984-01-01

    The physics of coronal transients, the characteristics of radiation and accelerated particles at the time of flares, and the density/temperature structure of the transition region and corona and the coronal magnetic field are investigated.

  18. Forward modeling corona growth in a partially eclogitized leucogabbro, Bourbon Island, North-East Greenland

    NASA Astrophysics Data System (ADS)

    Sartini-Rideout, C.; Gilotti, J. A.; Foster, C. T.

    2007-05-01

    Coronitic textures are common in partially eclogitized igneous bodies, such as gabbros, leucogabbros, and anorthosites, east of the Germania Land Deformation Zone in North-East Greenland. Coronas formed by prograde metamorphic processes that transformed the gabbroic bodies to eclogite facies, and record frozen stages of the prograde metamorphic evolution of these rocks. A metaleucogabbro-norite body on Bourbon Island in Jøkelbugt is characterized by three concentric areas: a coronitic core, a mottled inner rim with areas of completely eclogitized material surrounded by a matrix of coronitic metaleucogabbro, and an outer rim of strongly foliated and completely retrogressed amphibolite. The Bourbon body preserves four stages of the prograde metamorphic history: Stage I, Stage II, Stage III, and Eclogite Stage. Stage I coronas are found only in the core of the body, which is the least reacted part of the leucogabbro-norite and the closest to the protolith, and is characterized by the corona sequence Pl rim/Grt + Kfs + Amp/Grt + Amp/Cpx rim. The typical corona sequence for Stage II is Pl rim/Grt + Pl + Zo/Cpx rim/Amp rim. Stage III samples show a Pl rim + Ky + Scp/Grt + Pl + Qtz/Qtz + Pl sequence, with the relict clinopyroxene being replaced in part by microcrystalline aggregates of Cpx + Amp + Pl. The Eclogite Stage shows relict Pl completely replaced by Grt, and the relict Cpx completely replaced by aggregates of Omp + Pl + Kfs + Amp. We tested open-system grain boundary diffusion (OSGBD) theories to model the prograde Stage I symplectitic coronas. The observed ratio of the thickness of the different layers is Pl rim:Grt + Kfs + Amp:Grt + Amp:Cpx rim equal to 3:1.3:0.95:0.5. These ratios are very close to the modeled ones of 2.7:1.1:1:0.5. Furthermore, subtle textural changes within the Grt + Kfs + Amp corona were also reproduced by the model. The model gave us insight into the conditions of the metamorphic system in which the coronas formed. The sequence Pl rim

  19. Memprot: a program to model the detergent corona around a membrane protein based on SEC–SAXS data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pérez, Javier, E-mail: javier.perez@synchrotron-soleil.fr; Koutsioubas, Alexandros; Synchrotron SOLEIL, L’Orme des Merisiers, BP 48, Saint-Aubin, 91192 Gif-sur-Yvette

    Systematic SAXS simulations have been analysed over a wide range of parameters in order to better understand the detergent corona around a membrane protein. The application of small-angle X-ray scattering (SAXS) to structural investigations of transmembrane proteins in detergent solution has been hampered by two main inherent hurdles. On the one hand, the formation of a detergent corona around the hydrophobic region of the protein strongly modifies the scattering curve of the protein. On the other hand, free micelles of detergent without a precisely known concentration coexist with the protein–detergent complex in solution, therefore adding an uncontrolled signal. To gainmore » robust structural information on such systems from SAXS data, in previous work, advantage was taken of the online combination of size-exclusion chromatography (SEC) and SAXS, and the detergent corona around aquaporin-0, a membrane protein of known structure, could be modelled. A precise geometrical model of the corona, shaped as an elliptical torus, was determined. Here, in order to better understand the correlations between the corona model parameters and to discuss the uniqueness of the model, this work was revisited by analyzing systematic SAXS simulations over a wide range of parameters of the torus.« less

  20. [Action-oriented versus state-oriented reactions to experimenter-induced failures].

    PubMed

    Brunstein, J C

    1989-01-01

    The present study assessed different effects of action-oriented versus state-oriented styles of coping with failure on achievement-related performance and cognition. In a learned helplessness experiment, students were exposed to an academic failure situation and were then tested on a series of problem-solving tasks, either immediately after the pretreatment or after a delay of 24 hours. Performance and cognitive concomitants were measured during both experimental periods. Results demonstrated that action orientation was associated with self-immunizing cognitions during helplessness training. Action-oriented participants improved their performance level even after repeated failure feedbacks. Moreover, action-oriented students assigned to the delayed test condition responded with increased striving for success and showed performance increments, even in comparison with control subjects. In contrast, state-oriented participants developed symptoms of helplessness and showed impaired performance during failure inductions. In later tests on problem-solving tasks, state-oriented groups responded with increased fear of failure. Independent of immediate or delayed test conditions, they soon lapsed into new performance decrements.

  1. Degradation of methylparaben in water by corona plasma coupled with ozonation.

    PubMed

    Dobrin, D; Magureanu, M; Bradu, C; Mandache, N B; Ionita, P; Parvulescu, V I

    2014-11-01

    The degradation of methylparaben (MeP) in water was investigated using a pulsed corona discharge generated in oxygen, above the liquid. A comparison was made between results obtained in semi-batch corona (SBC) configuration (stationary solution, continuous gas flow) and results obtained in a semi-batch corona with recirculation combined with ozonation (SBCR + O3), where the liquid is continuously circulated between a solution reservoir and the plasma reactor and the effluent gas containing ozone is bubbled through the solution in the reservoir. It was found that MeP was completely degraded after 10-15 min of treatment in both configurations. Oxidation by ozone alone, in the absence of plasma, was a slower process. The energy efficiency for MeP removal (Y MeP) and for mineralization (Y TOC) was significantly higher in the SBCR + O3 configuration (Y MeP = 7.1 g/kWh at 90 % MeP removal and Y TOC = 0.41 g/kWh at 50 % total organic carbon (TOC) removal) than in the SBC configuration (Y MeP = 0.6 g/kWh at 90 % MeP removal and Y TOC = 0.11 g/kWh at 50 % TOC removal).

  2. The pressure and energy balance of the cool corona over sunspots

    NASA Technical Reports Server (NTRS)

    Foukal, P. V.

    1976-01-01

    The 22 largest sunspots observed with the Skylab SO55 spectrometer are studied for a relation between their EUV radiation and their umbral size or magnetic classification. The ultimate goal is to determine why the coronal plasma is so cool over a sunspot and how this cool plasma manages to support itself against gravity. Based on the time behavior of the EUV emission, a steady-state model is developed for the pressure and energy balance of the cool coronal-plasma loops over the spots. Analysis of the temperature structure in a typical loop indicates that the loop is exceedingly well insulated from the outside corona, that its energy balance is determined purely by internal heating and cooling processes, and that a heat input of about 0.0001 erg/cu cm per sec is required along the full length of the loop. It is proposed that: (1) coronal material flows steadily across the field lines at the tops of the loops and falls downward along both sides under gravity; (2) the corona is heated by mechanical-energy transport across the very thin transition region immediately over network-cell interiors; and (3) strong magnetic fields tend to inhibit mechanical-energy dissipation in the corona.

  3. A comparison of the human and mouse protein corona profiles of functionalized SiO2 nanocarriers.

    PubMed

    Solorio-Rodríguez, A; Escamilla-Rivera, V; Uribe-Ramírez, M; Chagolla, A; Winkler, R; García-Cuellar, C M; De Vizcaya-Ruiz, A

    2017-09-21

    Nanoparticles are a promising cancer therapy for their use as drug carriers given their versatile functionalization with polyethylene glycol and proteins that can be recognized by overexpressed receptors in tumor cells. However, it has been suggested that in biological fluids, proteins cover nanoparticles, which gives the proteins a biological identity that could be responsible for unexpected biological responses: the so-called protein corona. A relevant biological event that is usually ignored in protein-corona formation is the interspecies differences in protein binding, which can be involved in the discrepancies observed in preclinical studies and the nanoparticle safety and efficiency. Hence, the aim of this study was to determine the differences between human and mouse plasma protein corona profiles in an active therapy model using silicon dioxide nanoparticles (SiO 2 nanoparticles) functionalized with polyethylene glycol and transferrin. Functionalized SiO 2 nanoparticles were made with a primary particle size of 25 nm and a transferrin content of 50 μg mg -1 of nanoparticles and were PEGylated with a cross-linker. The proteomic analysis by nanoliquid chromatography tandem-mass spectrometry (nanoLC-MS/MS) showed interspecies differences. The most abundant proteins found in the human protein corona profile were immunoglobulins, actin cytoplasmic 1, hemoglobin subunit beta, serotransferrin, ficolin-3, complement C3, and apolipoprotein A-1. Meanwhile, the mouse protein corona adsorbed the serine protease inhibitor A3K, serotransferrin, alpha-1-antitrypsin 1-2, hemoglobin subunit beta, and fibrinogen gamma and beta chains. These protein-corona profile differences in the functionalized SiO 2 nanoparticles indicate that biological responses observed in in vivo models could not be translated to clinical use and must be considered in the interpretation of preclinical trials in order to design more efficient and safer nanomedicines.

  4. Magnetic Untwisting in Solar Jets that Go into the Outer Corona in Polar Coronal Holes

    NASA Technical Reports Server (NTRS)

    Moore, Ronald L.; Sterling, Alphonse C.; Falconer, David A.

    2014-01-01

    We present results from 14 exceptionally high-reaching large solar jets observed in the polar coronal holes. EUV movies from SDO/AIA show that each jet is similar to many other similar-size and smaller jets that erupt in coronal holes, but each is exceptional in that it goes higher than most other jets, so high that it is observed in the outer corona beyond 2.2 R(sub Sun) in images from the SOHO/LASCO/C2 coronagraph. For these high-reaching jets, we find: (1) the front of the jet transits the corona below 2.2 R(sub Sun) at a speed typically several times the sound speed; (2) each jet displays an exceptionally large amount of spin as it erupts; (3) in the outer corona, most jets display oscillatory swaying having an amplitude of a few degrees and a period of order 1 hour. We conclude that these jets are magnetically driven, propose that the driver is a magnetic-untwisting wave that is grossly a large-amplitude (i.e., nonlinear) torsional Alfven wave that is put into the reconnected open magnetic field in the jet by interchange reconnection as the jet erupts, and estimate from the measured spinning and swaying that the magnetic-untwisting wave loses most of its energy in the inner corona below 2.2 R(sub Sun). From these results for these big jets, we reason that the torsional magnetic waves observed in Type-II spicules should dissipate in the corona in the same way and could thereby power much of the coronal heating in coronal holes.

  5. Discovery of Finely Structured Dynamic Solar Corona Observed in the Hi-C Telescope

    NASA Technical Reports Server (NTRS)

    Winebarger, A.; Cirtain, J.; Golub, L.; DeLuca, E.; Savage, S.; Alexander, C.; Schuler, T.

    2014-01-01

    In the summer of 2012, the High-resolution Coronal Imager (Hi-C) flew aboard a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore examine how the intensity scales from AIA resolution to Hi-C resolution. For each low-resolution pixel, we calculate the standard deviation in the contributing high-resolution pixel intensities and compare that to the expected standard deviation calculated from the noise. If these numbers are approximately equal, the corona can be assumed to be smoothly varying, i.e. have no evidence of substructure in the Hi-C image to within Hi-C's ability to measure it given its throughput and readout noise. A standard deviation much larger than the noise value indicates the presence of substructure. We calculate these values for each low-resolution pixel for each frame of the Hi-C data. On average, 70 percent of the pixels in each Hi-C image show no evidence of substructure. The locations where substructure is prevalent is in the moss regions and in regions of sheared magnetic field. We also find that the level of substructure varies significantly over the roughly 160 s of the Hi-C data analyzed here. This result indicates that the finely structured corona is concentrated in regions of heating and is highly time dependent.

  6. DISCOVERY OF FINELY STRUCTURED DYNAMIC SOLAR CORONA OBSERVED IN THE Hi-C TELESCOPE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Winebarger, Amy R.; Cirtain, Jonathan; Savage, Sabrina

    In the Summer of 2012, the High-resolution Coronal Imager (Hi-C) flew on board a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore examine how the intensity scales from AIA resolution to Hi-C resolution. For each low-resolution pixel, we calculate the standard deviation in the contributing high-resolution pixel intensities and compare that to the expected standard deviation calculated from the noise. If these numbers are approximately equal, the corona can be assumed to bemore » smoothly varying, i.e., have no evidence of substructure in the Hi-C image to within Hi-C's ability to measure it given its throughput and readout noise. A standard deviation much larger than the noise value indicates the presence of substructure. We calculate these values for each low-resolution pixel for each frame of the Hi-C data. On average, 70% of the pixels in each Hi-C image show no evidence of substructure. The locations where substructure is prevalent is in the moss regions and in regions of sheared magnetic field. We also find that the level of substructure varies significantly over the roughly 160 s of the Hi-C data analyzed here. This result indicates that the finely structured corona is concentrated in regions of heating and is highly time dependent.« less

  7. Solar Energetic Particle Events and CME Accelerations in the Low Corona: MLSO Observations

    NASA Astrophysics Data System (ADS)

    St Cyr, O. C.; Kahler, S. W.; Richardson, I. G.; Cane, H. V.; Xie, H.; Burkepile, J.

    2016-12-01

    The low solar corona (< 2.5 Rs) is the region in which maximum coronal mass ejection (CME) acceleration occurs and where Type II radio observations suggest that shock formation occurs (Mäkelä et al., 2015). It is therefore a key region for investigations of solar energetic particle (SEP) acceleration by CME-driven shocks. Observations very low in the corona are necessary to detect the rapid CME accelerations leading to shock formation and to assess the speeds of CMEs through the middle corona. However, these observations cannot be made by space borne coronagraphs in which CME trajectories above the occulting disk are usually characterized by a single (constant) speed: e.g., 80% of the speeds in the compilation of SMM CMEs (Burkepile and St. Cyr, 1993) and SOHO LASCO CMEs (St. Cyr et al., 2000). The Mk3/Mk4/K-Cor coronameters at the Mauna Loa Solar Observatory are able to measure the initial accelerations of CMEs low in the corona (i.e., < 2 Rs). We examine a subset of CMEs that were associated with SEP events between 1980-present. The subset is based on the CME launch occurring between 16 UT - 01 UT - the MLSO observing window. In most cases, the CME accelerations are significantly larger than those measured by spaceborne coronagraphs (e.g., SMM, Solwind, LASCO, SECCHI). We will present the preliminary results of a comparison of the SEP parameters with initial CME accelerations in the MLSO coronagraph field of view.

  8. Ozone generation by negative direct current corona discharges in dry air fed coaxial wire-cylinder reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yehia, Ashraf; Mizuno, Akira

    An analytical study was made in this paper for calculating the ozone generation by negative dc corona discharges. The corona discharges were formed in a coaxial wire-cylinder reactor. The reactor was fed by dry air flowing with constant rates at atmospheric pressure and room temperature, and stressed by a negative dc voltage. The current-voltage characteristics of the negative dc corona discharges formed inside the reactor were measured in parallel with concentration of the generated ozone under different operating conditions. An empirical equation was derived from the experimental results for calculating the ozone concentration generated inside the reactor. The results, thatmore » have been recalculated by using the derived equation, have agreed with the experimental results over the whole range of the investigated parameters, except in the saturation range for the ozone concentration. Therefore, the derived equation represents a suitable criterion for expecting the ozone concentration generated by negative dc corona discharges in dry air fed coaxial wire-cylinder reactors under any operating conditions in range of the investigated parameters.« less

  9. A morphological study of the changes in the ultrastructure of a bacterial biofilm disrupted by an ac corona discharge in air

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stepanova, Olga, E-mail: o.m.stepanova@spbu.ru; Astafiev, Alexander; Kudryavtsev, Anatoly

    The morphology of bacterial cells and biofilms subjected to a low frequency (∼10{sup 5} Hz) ac (∼10{sup −1} A) corona discharge was investigated using electron microscopy. A low-frequency ac corona discharge in air is shown to have a bactericidal and bacteriostatic effect on Escherichia coli M17 culture at both the cellular and population levels. Corona exposure inhibits the formation of a microbial community and results in the destruction of formed biofilms. This paper presents data on changes in the ultrastructure of cells and biofilms after corona treatment. Our results suggest that the E. coli M17 cells inside biofilms are affectedmore » with results similar to sub-lethal and lethal thermal exposure. Some of the biological aspects of colony and biofilm cells death are evaluated. Morphological changes in the ultrastructure of the biofilms under corona treatment are described. Our results indicate that the heating effect is the main factor responsible for the corona-induced inactivation of bacteria.« less

  10. Incremental k-core decomposition: Algorithms and evaluation

    DOE PAGES

    Sariyuce, Ahmet Erdem; Gedik, Bugra; Jacques-SIlva, Gabriela; ...

    2016-02-01

    A k-core of a graph is a maximal connected subgraph in which every vertex is connected to at least k vertices in the subgraph. k-core decomposition is often used in large-scale network analysis, such as community detection, protein function prediction, visualization, and solving NP-hard problems on real networks efficiently, like maximal clique finding. In many real-world applications, networks change over time. As a result, it is essential to develop efficient incremental algorithms for dynamic graph data. In this paper, we propose a suite of incremental k-core decomposition algorithms for dynamic graph data. These algorithms locate a small subgraph that ismore » guaranteed to contain the list of vertices whose maximum k-core values have changed and efficiently process this subgraph to update the k-core decomposition. We present incremental algorithms for both insertion and deletion operations, and propose auxiliary vertex state maintenance techniques that can further accelerate these operations. Our results show a significant reduction in runtime compared to non-incremental alternatives. We illustrate the efficiency of our algorithms on different types of real and synthetic graphs, at varying scales. Furthermore, for a graph of 16 million vertices, we observe relative throughputs reaching a million times, relative to the non-incremental algorithms.« less

  11. Corona[5]arenes Accessed by a Macrocycle-to-Macrocycle Transformation Route and a One-Pot Three-Component Reaction.

    PubMed

    Wu, Zhi-Chen; Guo, Qing-Hui; Wang, Mei-Xiang

    2017-06-12

    Corona[5]arenes, a novel type of macrocyclic compound that is composed of alternating heteroatoms and para-arylenes, were synthesized efficiently by two distinct methods. In a macrocycle-to-macrocycle transformation approach, S 6 -corona[3]arene[3]tetrazine underwent sequential S N Ar reactions with HS-C 6 H 4 -X-C 6 H 4 -SH (X=S, CH 2 , CMe 2 , SO 2 , and O) to produce the corresponding corona[3]arene[2]tetrazines. Different corona[3]arene[2]tetrazine compounds were also constructed in a straightforward manner by a one-pot three-component reaction of HS-C 6 H 4 -X-C 6 H 4 -SH (X=S, CH 2 , CMe 2 , SO 2 , and O) with diethyl 2,5-dimercaptoterephthalate and 2 equiv of 3,6-dichlorotetrazine under very mild conditions. All corona[5]arenes adopted 1,2,4-alternate conformational structures in the crystalline state yielding similar nearly regular pentagonal cavities. Both the cavity size and the electronic property of the acquired macrocycles were fine-tuned by the nature of the bridging element X. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Efficiency of Oral Incremental Rehearsal versus Written Incremental Rehearsal on Students' Rate, Retention, and Generalization of Spelling Words

    ERIC Educational Resources Information Center

    Garcia, Dru; Joseph, Laurice M.; Alber-Morgan, Sheila; Konrad, Moira

    2014-01-01

    The purpose of this study was to examine the efficiency of an incremental rehearsal oral versus an incremental rehearsal written procedure on a sample of primary grade children's weekly spelling performance. Participants included five second and one first grader who were in need of help with their spelling according to their teachers. An…

  13. Heating mechanisms of the solar corona

    PubMed Central

    SAKURAI, Takashi

    2017-01-01

    The solar corona is a tenuous outer atmosphere of the Sun. Its million-degree temperature was discovered spectroscopically in the 1940s, but its origin has been debated since then without complete convergence. Currently there are two classes of models; the wave theory and the microflare/nanoflare theory. Both models have merits and disadvantages, but the essential issues are nearly pinned down. Recent revival of the wave theory is one of the many contributions from Japanese solar observing satellite Hinode launched in 2006. PMID:28190871

  14. Origin of biotite-hornblende-garnet coronas between oxides and plagioclase in olivine metagabbros, Adirondack region, New York

    USGS Publications Warehouse

    Whitney, P.R.; McLelland, J.M.

    1982-01-01

    Complex multivariant reactions involving Fe-Ti oxide minerals, plagioclase and olivine have produced coronas of biotite, hornblende and garnet between ilmenite and plagioclase in Adirondack olivine metagabbros. Both the biotite (6-10% TiO2) and the hornblende (3-6% TiO2) are exceptionally Titanium-rich. The garnet is nearly identical in composition to the garnet in coronas around olivine in the same rocks. The coronas form in two stages: (a) Plagioclase+Fe-Ti Oxides+Olivine+water =Hornblende+Spinel+Orthopyroxene??Biotite +more-sodic Plagioclase (b) Hornblende+Orthopyroxene??Spinel+Plagioclase =Garnet+Clinopyroxene+more-sodic Plagioclase The Orthopyroxene and part of the clinopyroxene form adjacent to olivine. Both reactions are linked by exchange of Mg2+ and Fe2+ with the reactions forming pyroxene and garnet coronas around olivine in the same rocks. The reactions occur under granulite fades metamorphic conditions, either during isobaric cooling or with increasing pressure at high temperature. ?? 1983 Springer-Verlag.

  15. Decontamination of Streptococci biofilms and Bacillus cereus spores on plastic surfaces with DC and pulsed corona discharges

    NASA Astrophysics Data System (ADS)

    Koval'ová, Zuzana; Tarabová, Kataŕna; Hensel, Karol; Machala, Zdenko

    2013-02-01

    Cold air plasmas of DC and pulsed corona discharges: positive streamers and negative Trichel pulses were used for bio-decontamination of Streptococci biofilm and Bacillus cereus spores on polypropylene plastic surfaces. The reduction of bacterial population (evaluated as log10) in the biofilm on plastic surfaces treated by DC corona reached 2.4 logs with 10 min treatment time and 3.3 logs with 2 min treatment time with water spraying. The enhancement of plasma biocidal effects on the biofilm by electro-spraying of water through a hollow needle high-voltage electrode was investigated. No significant polarity effect was found with DC corona. Pulsed corona was demonstrated slightly more bactericidal for spores, especially in the negative polarity where the bacterial population reduction reached up to 2.2 logs at 10 min exposure time. Contribution to the Topical Issue "13th International Symposium on High Pressure Low Temperature Plasma Chemistry (Hakone XIII)", Edited by Nicolas Gherardi, Henryca Danuta Stryczewska and Yvan Ségui.

  16. Tuning the Protein Corona of Hydrogel Nanoparticles: The Synthesis of Abiotic Protein and Peptide Affinity Reagents.

    PubMed

    O'Brien, Jeffrey; Shea, Kenneth J

    2016-06-21

    Nanomaterials, when introduced into a complex, protein-rich environment, rapidly acquire a protein corona. The type and amount of proteins that constitute the corona depend significantly on the synthetic identity of the nanomaterial. For example, hydrogel nanoparticles (NPs) such as poly(N-isopropylacrylamide) (NIPAm) have little affinity for plasma proteins; in contrast, carboxylated poly(styrene) NPs acquire a dense protein corona. This range of protein adsorption suggests that the protein corona might be "tuned" by controlling the chemical composition of the NP. In this Account, we demonstrate that small libraries of synthetic polymer NPs incorporating a diverse pool of functional monomers can be screened for candidates with high affinity and selectivity to targeted biomacromolecules. Through directed synthetic evolution of NP compositions, one can tailor the protein corona to create synthetic organic hydrogel polymer NPs with high affinity and specificity to peptide toxins, enzymes, and other functional proteins, as well as to specific domains of large proteins. In addition, many NIPAm NPs undergo a change in morphology as a function of temperature. This transformation often correlates with a significant change in NP-biomacromolecule affinity, resulting in a temperature-dependent protein corona. This temperature dependence has been used to develop NP hydrogels with autonomous affinity switching for the protection of proteins from thermal stress and as a method of biomacromolecule purification through a selective thermally induced catch and release. In addition to temperature, changes in pH or buffer can also alter a NP protein corona composition, a property that has been exploited for protein purification. Finally, synthetic polymer nanoparticles with low nanomolar affinity for a peptide toxin were shown to capture and neutralize the toxin in the bloodstream of living mice. While the development of synthetic polymer alternatives to protein affinity reagents is

  17. 17 CFR 242.612 - Minimum pricing increment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Minimum pricing increment. 242.612 Section 242.612 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED...-Regulation of the National Market System § 242.612 Minimum pricing increment. (a) No national securities...

  18. Inactivation of bacteria using dc corona discharge: role of ions and humidity.

    PubMed

    Dobrynin, Danil; Friedman, Gary; Fridman, Alexander; Starikovskiy, Andrey

    2011-10-01

    Here we present the results of an experimental study of the effect of ions produced in a dc corona discharge on inactivation of bacteria on the surface of agarose gel. Both positive and negative corona discharges in various gases at different humidities were studied. The measurements in air, O(2), N(2), Ar and He mixtures show that there is no inactivation in pure N(2), pure O(2) and an N(2)-H(2)O mixture. The best results were achieved in the case of direct treatment, when discharge was ignited in oxygen and water-containing mixtures. We show that neither UV radiation, ozone or H(2)O(2) nor other neutral active species alone produced by corona have an effect on bacteria viability. It is shown that the main role of charged particles may be related to the faster transport of active peroxide species-cluster ions OH(-)(H(2)O)(n) and H(3)O(+)(H(2)O)(n). The efficiency of these radicals is much higher than that of the oxygen radicals and ions (including [Formula: see text] and O(3)) and that of nitrogen and argon ions.

  19. Logistics Modernization Program Increment 2 (LMP Inc 2)

    DTIC Science & Technology

    2016-03-01

    Executive DoD - Department of Defense DoDAF - DoD Architecture Framework FD - Full Deployment FDD - Full Deployment Decision FY - Fiscal Year IA...Documentation within the LMP Increment 2 MS C ADM, the LMP Increment 2 Business Case was updated for the FDD using change pages to remove information...following approval of the Army Cost Position being developed for the FDD . The LMP Increment 2 Business Case Change Pages were approved and signed by the

  20. 76 FR 72675 - Voluntary Termination of Foreign-Trade Subzone 90A Smith Corona Corporation, Cortland County, New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1799] Voluntary Termination of Foreign-Trade Subzone 90A Smith Corona Corporation, Cortland County, New York Pursuant to the authority granted... Smith Corona Corporation plant in Cortland County, New York (Board Order 300, 50 FR 15469, 04/18/85...

  1. Corona cell RNA sequencing from individual oocytes revealed transcripts and pathways linked to euploid oocyte competence and live birth.

    PubMed

    Parks, Jason C; Patton, Alyssa L; McCallie, Blair R; Griffin, Darren K; Schoolcraft, William B; Katz-Jaffe, Mandy G

    2016-05-01

    Corona cells surround the oocyte and maintain a close relationship through transzonal processes and gap junctions, and may be used to assess oocyte competence. In this study, the corona cell transcriptome of individual cumulus oocyte complexes (COCs) was investigated. Isolated corona cells were collected from COCs that developed into euploid blastocysts and were transferred in a subsequent frozen embryo transfer. Ten corona cell samples underwent RNA-sequencing to generate unique gene expression profiles. Live birth was compared with negative implantation after the transfer of a euploid blastocyst using bioinformatics and statistical analysis. Individual corona cell samples produced a mean of 21.2 million sequence reads, and 307 differentially expressed transcrpits (P < 0.05; fold change ≥ 2). Enriched pathway analysis showed Wnt signalling, mitogen-activated protein kinases signalling, focal adhesion and tricarboxylic acid cycle to be affected by implantation outcome. The Wnt/beta-catenin signalling pathway, including genes APC, AXIN and GSK3B, were independently validated by real-time quantitative reverse transcription. Individual, corona cell transcriptome was successfully generated using RNA-sequencing. Key genes and signalling pathways were identified in association with implantation outcome after the transfer of a euploid blastocyst in a frozen embryo transfer. These data could provide novel biomarkers for the non-invasive assessment of embryo viability. Copyright © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  2. Studies of Coronae and Large Volcanoes on Venus: Constraining the Diverse Outcomes of Small-Scale Mantle Upwellings on Venus

    NASA Technical Reports Server (NTRS)

    Stofan, Ellen R.

    2005-01-01

    Proxemy Research had a grant from NASA to perform science research on upwelling and volcanism on Venus. This was a 3 year Planetary Geology and Geophysics grant to E. Stofan, entitled Coronae and Large volcanoes on Venus. This grant closes on 12/31/05. Here we summarize the scientific progress and accomplishments of this grant. Scientific publications and abstracts of presentations are indicated in the final section. This was a very productive grant and the progress that was made is summarized. Attention is drawn to the publications and abstracts published in each year. The proposal consisted of two tasks, one examining coronae and one studying large volcanoes. The corona task (Task 1) consisted of three parts: 1) a statistical study of the updated corona population, with Sue Smrekar, Lori Glaze, Paula Martin and Steve Baloga; 2) geologic analysis of several specific groups of coronae, with Sue Smrekar and others; and 3) determining the histories and significance of a number of coronae with extreme amounts of volcanism, with Sue Smrekar. Task 2, studies of large volcanoes, consisted of two subtasks. In the first, we studied the geologic history of several volcanoes, with John Guest, Peter Grindrod, Antony Brian and Steve Anderson. In the second subtask, I analyzed a number of Venusian volcanoes with evidence of summit diking along with Peter Grindrod and Francis Nimmo.

  3. The influence of the breakdown electric field in the configuration of lightning corona sheath on charge distribution in the channel

    NASA Astrophysics Data System (ADS)

    Ignjatovic, Milan; Cvetic, Jovan; Heidler, Fridolin; Markovic, Slavoljub; Djuric, Radivoje

    2014-11-01

    A model of corona sheath that surrounds the thin core of the lightning channel has been investigated by using a generalized traveling current source return stroke model. The lightning channel is modeled by a charged corona sheath that stretches around a highly conductive central core through which the main current flows. The channel core with the negatively charged outer channel sheath forms a strong electric field, with an overall radial orientation. The return stroke process is modeled as the negative leader charge in the corona sheath being discharged by the positive charge coming from the channel core. Expressions that describe how the corona sheath radius evolves during the return stroke are obtained from the corona sheath model, which predicts charge motion within the sheath. The corona sheath model, set forth by Maslowski and Rakov (2006), Tausanovic et al. (2010), Marjanovic and Cvetic (2009), Cvetic et al. (2011) and Cvetic et al. (2012), divides the sheath onto three zones: zone 1 (surrounding the channel core with net positive charge), zone 2 (surrounding zone 1 with negative charge) and zone 3 (the outer zone, representing uncharged virgin air). In the present study, we have assumed a constant electric field inside zone 1, as suggested by experimental research of corona discharges in coaxial geometry conducted by Cooray (2000). The present investigation builds upon previous studies by Tausanovic et al. (2010) and Cvetic et al. (2012) in several ways. The value of the breakdown electric field has been varied for probing its effect on channel charge distribution prior and during the return stroke. With the aim of investigating initial space charge distribution along the channel, total electric field at the outer surface of the channel corona sheath, just before the return stroke, is calculated and compared for various return stroke models. A self-consistent algorithm is applied to the generalized traveling current source return stroke model, so that the

  4. MODELING THE LINE-OF-SIGHT INTEGRATED EMISSION IN THE CORONA: IMPLICATIONS FOR CORONAL HEATING

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Viall, Nicholeen M.; Klimchuk, James A.

    2013-07-10

    One of the outstanding problems in all of space science is uncovering how the solar corona is heated to temperatures greater than 1 MK. Though studied for decades, one of the major difficulties in solving this problem has been unraveling the line-of-sight (LOS) effects in the observations. The corona is optically thin, so a single pixel measures counts from an indeterminate number (perhaps tens of thousands) of independently heated flux tubes, all along that pixel's LOS. In this paper we model the emission in individual pixels imaging the active region corona in the extreme ultraviolet. If LOS effects are notmore » properly taken into account, erroneous conclusions regarding both coronal heating and coronal dynamics may be reached. We model the corona as an LOS integration of many thousands of completely independently heated flux tubes. We demonstrate that despite the superposition of randomly heated flux tubes, nanoflares leave distinct signatures in light curves observed with multi-wavelength and high time cadence data, such as those data taken with the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory. These signatures are readily detected with the time-lag analysis technique of Viall and Klimchuk in 2012. Steady coronal heating leaves a different and equally distinct signature that is also revealed by the technique.« less

  5. Mass and energy flows between the Solar chromosphere, transition region, and corona

    NASA Astrophysics Data System (ADS)

    Hansteen, V. H.

    2017-12-01

    A number of increasingly sophisticated numerical simulations spanning the convection zone to corona have shed considerable insight into the role of the magnetic field in the structure and energetics of the Sun's outer atmosphere. This development is strengthened by the wealth of observational data now coming on-line from both ground based and space borne observatories. We discuss what numerical models can tell us about the mass and energy flows in the region of the upper chromosphere and lower corona, using a variety of tools, including the direct comparison with data and the use of passive tracer particles (so-called 'corks') inserted into the simulated flows.

  6. The Effect of a Corona Discharge on a Lightning Attachment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aleksandrov, N.L.; Bazelyan, E.M.; Raizer, Yu.P.

    2005-01-15

    The interaction between the lightning leader and the space charge accumulated near the top of a ground object in the atmospheric electric field is considered using analytical and numerical models developed earlier to describe spark discharges in long laboratory gaps. The specific features of a nonstationary corona discharge that develops in the electric field of a thundercloud and a downward lightning leader are analyzed. Conditions for the development of an upward lightning discharge from a ground object and for the propagation of an upward-connecting leader from the object toward a downward lightning leader (the process determining the point of strikemore » to the ground) are investigated. Possible mechanisms for the interaction of the corona space charge with an upward leader and prospects of using it to control downward lightning discharges are analyzed.« less

  7. New Views of the Solar Corona from STEREO and SDO

    NASA Astrophysics Data System (ADS)

    Vourlidas, A.

    2012-01-01

    In the last few years, we have been treated to an unusual visual feast of solar observations of the corona in EUV wavelengths. The observations from the two vantage points of STEREO/SECCHI are now capturing the entire solar atmosphere simultaneously in four wavelengths. The SDO/AIA images provide us with arcsecond resolution images of the full visible disk in ten wavelengths. All these data are captured with cadences of a few seconds to a few minutes. In this talk, I review some intriguing results from our first attempts to deal with these observations which touch upon the problems of coronal mass ejection initiation and solar wind generation. I will also discuss data processing techniques that may help us recover even more information from the images. The talk will contain a generous portion of beautiful EUV images and movies of the solar corona.

  8. Characteristics of shocks in the solar corona, as inferred from radio, optical, and theoretical investigations

    NASA Technical Reports Server (NTRS)

    Maxwell, A.; Dryer, M.

    1982-01-01

    Solar radio bursts of spectral type II provide one of the chief diagnostics for the propagation of shocks through the solar corona. Radio data on the shocks are compared with computer models for propagation of fast-mode MHD shocks through the solar corona. Data on coronal shocks and high-velocity ejecta from solar flares are then discussed in terms of a general model consisting of three main velocity regimes.

  9. Increment cores : how to collect, handle and use them

    Treesearch

    Robert R. Maeglin

    1979-01-01

    This paper describes increment cores (a useful tool in forestry and wood technology) and their uses which include age determination, growth increment, specific gravity determination, fiber length measurements, fibril angle measurements, cell measurements, and pathological investigations. Also described is the use and care of the increment borer which is essential in...

  10. Dynamics of a lightning corona sheath—A constant field approach using the generalized traveling current source return stroke model

    NASA Astrophysics Data System (ADS)

    Cvetic, Jovan; Heidler, Fridolin; Markovic, Slavoljub; Radosavljevic, Radovan; Osmokrovic, Predrag

    2012-11-01

    A generalized lightning traveling current source return stroke model has been used to examine the characteristics of the lightning channel corona sheath surrounding a thin channel core. A model of the lightning channel consisting of a charged corona sheath and a narrow, highly conducting central core that conducts the main current flow is assumed. Strong electric field, with a predominant radial direction, has been created during the return stroke between the channel core and the outer channel sheath containing the negative charge. The return stroke process is modeled with the positive charge coming from the channel core discharging the negative leader charge in the corona sheath. The corona sheath model that predicts the charge motion in the sheath is used to derive the expressions of the sheath radius vs. time during the return stroke. According to the corona sheath model proposed earlier by Maslowski and Rakov (2006) and Maslowski et al. (2009), it consists of three zones, zone 1 (surrounding channel core with net positive charge), zone 2 (surrounding zone 1 with negative charge) and zone 3 (outer zone representing the virgin air without charges). We adopted the assumption of a constant electric field inside zone 1 of the corona sheath observed in the experimental research of corona discharges in a coaxial geometry by Cooray (2000). This assumption seems to be more realistic than the assumption of a uniform corona space charge density used previously in the study of Maslowski and Rakov (2006), Marjanovic and Cvetic (2009), and Tausanovic et al. (2010). Applying the Gauss' law on the infinitesimally small cylindrical section of the channel the expressions for time-dependence of the radii of zones 1 and 2 during the return stroke are derived. The calculations have shown that the overall channel dynamics concerning electrical discharge is roughly 50% slower and the maximum radius of zone 1 is about 33% smaller compared to the corresponding values calculated in the

  11. Combining neuroendocrine inhibitors in heart failure: reflections on safety and efficacy.

    PubMed

    Jneid, Hani; Moukarbel, George V; Dawson, Bart; Hajjar, Roger J; Francis, Gary S

    2007-12-01

    Neuroendocrine activation in heart failure has become the major target of pharmacotherapy for this growing epidemic. Agents targeting the renin-angiotensin-aldosterone and sympathetic nervous systems have shown cardiovascular and survival benefits in clinical trials. Beta-blockers and angiotensin-converting enzyme (ACE) inhibitors remain the mainstream initial therapy. The benefits of aldosterone antagonists have been demonstrated in advanced heart failure (spironolactone) and after myocardial infarction complicated by left ventricular dysfunction and heart failure (eplerenone). Emerging clinical evidence demonstrated that angiotensin receptor blockers may be a reasonable alternative to ACE inhibitors in patients with heart failure (candesartan) and following myocardial infarction complicated by heart failure or left ventricular dysfunction (valsartan). Angiotensin receptor blockers (candesartan) also provided incremental benefits when added to ACE inhibitors in chronic heart failure. Thus, combining neuroendocrine inhibitors in heart failure appears both biologically plausible and evidence-based. However, this approach raised concerns about side effects, such as hypotension, renal insufficiency, hyperkalemia, and others. Close follow-up and implementation of evidence-based medicine (ie, using agents and doses proven beneficial in clinical trials) should therefore be undertaken when combining neuroendocrine inhibitors.

  12. The green corona database and the coronal index of solar activity

    NASA Astrophysics Data System (ADS)

    Minarovjech, M.; Rušin, V.; Saniga, M.

    2011-10-01

    The green coronal line Fe XIV 530.3 nm ranks amongst the most pronounced emission lines in the visible part of the solar spectrum. Its observations outside solar eclipses started sporadically in 1939 (the Arosa coronal station), being extended, in 1946, to more coronal stations. It was found that the green corona intensities vary with solar cycle, so they are a good candidate to express solar activity in the corona. Several attempts have been made to create a single homogeneous coronal data set from different coronal stations. We will present our homogeneous coronal data set, based on the Lomnický Štít photometric scale. Also, the coronal index of solar activity as created from this database in the period 1939—2010 will be discussed.

  13. Cost-Effectiveness of Sacubitril-Valsartan in Patients With Heart Failure With Reduced Ejection Fraction.

    PubMed

    Sandhu, Alexander T; Ollendorf, Daniel A; Chapman, Richard H; Pearson, Steven D; Heidenreich, Paul A

    2016-11-15

    Sacubitril-valsartan therapy reduces cardiovascular mortality compared with enalapril therapy in patients with heart failure with reduced ejection fraction. To evaluate the cost-effectiveness of sacubitril-valsartan versus angiotensin-converting enzyme inhibitor therapy in patients with chronic heart failure. Markov decision model. Clinical trials, observational analyses, reimbursement data from the Centers for Medicare & Medicaid Services, drug pricing databases, and Centers for Disease Control and Prevention life tables. Patients at an average age of 64 years, New York Heart Association (NYHA) class II to IV heart failure, and left ventricular ejection fraction of 0.40 or less. Lifetime. Societal. Treatment with sacubitril-valsartan or lisinopril. Life-years, quality-adjusted life-years (QALYs), costs, heart failure hospitalizations, and incremental cost-effectiveness ratios. The sacubitril-valsartan group experienced 0.08 fewer heart failure hospitalization, 0.69 additional life-year, 0.62 additional QALY, and $29 203 in incremental costs, equating to a cost per QALY gained of $47 053. The cost per QALY gained was $44 531 in patients with NYHA class II heart failure and $58 194 in those with class III or IV heart failure. Sacubitril-valsartan treatment was most sensitive to the duration of improved outcomes, with a cost per QALY gained of $120 623 if the duration was limited to the length of the trial (median, 27 months). No variations in other parameters caused the cost to exceed $100 000 per QALY gained. The benefit of sacubitril-valsartan is based on a single clinical trial. Treatment with sacubitril-valsartan provides reasonable value in reducing cardiovascular mortality and morbidity in patients with NYHA class II to IV heart failure. U.S. Department of Veterans Affairs and Institute for Clinical and Economic Review.

  14. Study on law of negative corona discharge in microparticle-air two-phase flow media

    NASA Astrophysics Data System (ADS)

    He, Bo; Li, Tianwei; Xiu, Yaping; Zhao, Heng; Peng, Zongren; Meng, Yongpeng

    2016-03-01

    To study the basic law of negative corona discharge in solid particle-air two-phase flow, corona discharge experiments in a needle-plate electrode system at different voltage levels and different wind speed were carried out in the wind tunnel. In this paper, the change law of average current and current waveform were analyzed, and the observed phenomena were systematically explained from the perspectives of airflow, particle charging, and particle motion with the help of PIV (particle image velocity) measurements and ultraviolet observations.

  15. [Do mastery goals buffer self-esteem from the threat of failure?].

    PubMed

    Niiya, Yu; Crocker, Jennifer

    2007-12-01

    Self-esteem is vulnerable when failure occurs in the domain where people base their self-worth (Crocker & Wolfe, 2001). We tested whether learning orientations can reduce the vulnerability of self-esteem associated with contingent self-worth and encourage persistence following failure. Our past research (Niiya, Crocker, & Bartmess, 2004) indicated that people who base their self-worth on academics maintain their self-esteem following failure when they are primed with an incremental theory of intelligence. Our present study extends these findings by (a) examining whether mastery goals (Elliot & Church, 1997) can also buffer self-esteem from failure, (b) using a different manipulation of success and failure, (c) using a different task, and (d) including a measure of persistence. We found that college students who based their self-esteem on academic competence reported lower self-esteem following failure than following success when they had low mastery goals, but the effect of success and failure was eliminated when students had high mastery goals. Moreover, high mastery students showed greater persistence following failure than low mastery students. The study provided converging evidence that learning orientations buffer self-esteem from failure.

  16. Novel dielectric reduces corona breakdown in ac capacitors

    NASA Technical Reports Server (NTRS)

    Loehner, J. L.

    1972-01-01

    Dielectric system was developed which consists of two layers of 25-gage paper separated by one layer of 50-gage polypropylene to reduce corona breakdown in ac capacitors. System can be used in any alternating current application where constant voltage does not exceed 400 V rms. With a little research it could probably be increased to 700 to 800 V rms.

  17. [Study of characteristics of excited O atom generated in multi-needle-to-plate corona discharge by emission spectroscopy].

    PubMed

    Ge, Hui; Yan, Ling; Mi, Dong; Zhu, Yi-min; Zhang, Lu

    2012-04-01

    The emission spectra of O(3p 5 P --> 3s 5 S2(0) 777.4 nm) produced by multi-needle-to-plate negative corona discharge and positive streamer discharge in air were successfully recorded at one atmosphere. The influences of discharge power, electrode gap, content of N2 and relative humidity on the excited O atom production were investigated in negative corona discharge. Meanwhile, the distribution of relative density of excited O atom in discharge space was also studied in positive streamer discharge. The results indicate that, for negative corona discharge, the amount of O active atom increases with the increase in power, decreases with increased discharge gap. And with the increase in relative humidity and N2 content, its amount firstly increases and then decreases; whereas for positive corona discharge, the relative density of O active atom from needlepoint to plate firstly increases and then decreases.

  18. A precise measurement of the magnetic field in the corona of the black hole binary V404 Cygni.

    PubMed

    Dallilar, Yigit; Eikenberry, Stephen S; Garner, Alan; Stelter, Richard D; Gottlieb, Amy; Gandhi, Poshak; Casella, Piergiorgio; Dhillon, Vik S; Marsh, Tom R; Littlefair, Stuart P; Hardy, Liam; Fender, Rob; Mooley, Kunal; Walton, Dominic J; Fuerst, Felix; Bachetti, Matteo; Castro-Tirado, A J; Charcos, Miguel; Edwards, Michelle L; Lasso-Cabrera, Nestor M; Marin-Franch, Antonio; Raines, S Nicholas; Ackley, Kendall; Bennett, John G; Cenarro, A Javier; Chinn, Brian; Donoso, H Veronica; Frommeyer, Raymond; Hanna, Kevin; Herlevich, Michael D; Julian, Jeff; Miller, Paola; Mullin, Scott; Murphey, Charles H; Packham, Chris; Varosi, Frank; Vega, Claudia; Warner, Craig; Ramaprakash, A N; Burse, Mahesh; Punnadi, Sujit; Chordia, Pravin; Gerarts, Andreas; de Paz Martín, Héctor; Calero, María Martín; Scarpa, Riccardo; Acosta, Sergio Fernandez; Hernández Sánchez, William Miguel; Siegel, Benjamin; Pérez, Francisco Francisco; Viera Martín, Himar D; Rodríguez Losada, José A; Nuñez, Agustín; Tejero, Álvaro; Martín González, Carlos E; Rodríguez, César Cabrera; Molgó, Jordi; Rodriguez, J Esteban; Cáceres, J Israel Fernández; Rodríguez García, Luis A; Lopez, Manuel Huertas; Dominguez, Raul; Gaggstatter, Tim; Lavers, Antonio Cabrera; Geier, Stefan; Pessev, Peter; Sarajedini, Ata

    2017-12-08

    Observations of binary stars containing an accreting black hole or neutron star often show x-ray emission extending to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the solar corona. Despite their ubiquity, the physical conditions in accretion disk coronae remain poorly constrained. Using simultaneous infrared, optical, x-ray, and radio observations of the Galactic black hole system V404 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 ± 12 gauss magnetic field measurement in the corona. This measurement is substantially lower than previous estimates for such systems, providing constraints on physical models of accretion physics in black hole and neutron star binary systems. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  19. An incremental approach to genetic-algorithms-based classification.

    PubMed

    Guan, Sheng-Uei; Zhu, Fangming

    2005-04-01

    Incremental learning has been widely addressed in the machine learning literature to cope with learning tasks where the learning environment is ever changing or training samples become available over time. However, most research work explores incremental learning with statistical algorithms or neural networks, rather than evolutionary algorithms. The work in this paper employs genetic algorithms (GAs) as basic learning algorithms for incremental learning within one or more classifier agents in a multiagent environment. Four new approaches with different initialization schemes are proposed. They keep the old solutions and use an "integration" operation to integrate them with new elements to accommodate new attributes, while biased mutation and crossover operations are adopted to further evolve a reinforced solution. The simulation results on benchmark classification data sets show that the proposed approaches can deal with the arrival of new input attributes and integrate them with the original input space. It is also shown that the proposed approaches can be successfully used for incremental learning and improve classification rates as compared to the retraining GA. Possible applications for continuous incremental training and feature selection are also discussed.

  20. Evolution of Magnetic Rayleigh–Taylor Instability into the Outer Solar Corona and Low Interplanetary Space

    NASA Astrophysics Data System (ADS)

    Mishra, Sudheer K.; Singh, Talwinder; Kayshap, P.; Srivastava, A. K.

    2018-03-01

    We analyze the observations from Solar TErrestrial RElations Observatory (STEREO)-A and B/COR-1 of an eruptive prominence in the intermediate corona on 2011 June 7 at 08:45 UT, which consists of magnetic Rayleigh–Taylor (MRT) unstable plasma segments. Its upper-northward segment shows spatio-temporal evolution of MRT instability in form of finger structures up to the outer corona and low interplanetary space. Using the method of Dolei et al., It is estimated that the density in each bright finger is greater than the corresponding dark region lying below it in the surrounding intermediate corona. The instability is evolved due to wave perturbations that are parallel to the magnetic field at the density interface. We conjecture that the prominence plasma is supported by tension component of the magnetic field against gravity. Through the use of linear stability theory, the magnetic field is estimated as 21–40 mG to suppress growth of MRT instability in the observed finger structures. In the southward plasma segment, a horn-like structure is observed at 11:55 UT in the intermediate corona that also indicates MRT instability. Falling blobs are also observed in both of the plasma segments. In the outer corona, up to 6–13 solar radii, the mushroom-like plasma structures have been identified in the upper-northward MRT unstable plasma segment using STEREO-A/COR-2. These structures most likely grew due to the breaking and twisting of fingers at large spatial scales in weaker magnetic fields. In the lower interplanetary space up to 20 solar radii, these structures are fragmented into various small-scale localized plasma spikes, most likely due to turbulent mixing.

  1. Collecting, preparing, crossdating, and measuring tree increment cores

    USGS Publications Warehouse

    Phipps, R.L.

    1985-01-01

    Techniques for collecting and handling increment tree cores are described. Procedures include those for cleaning and caring for increment borers, extracting the sample from a tree, core surfacing, crossdating, and measuring. (USGS)

  2. Removal of NO and SO2 in Corona Discharge Plasma Reactor with Water Film

    NASA Astrophysics Data System (ADS)

    He, Yuanji; Dong, Liming; Yang, Jiaxiang

    2004-04-01

    In this paper, a novel type of a corona discharge plasma reactor was designed, which consists of needle-plate-combined electrodes, in which a series of needle electrodes are placed in a glass container filled with flue gas, and a plate electrode is immersed in the water. Based on this model, the removal of NO and SO2 was tested experimentally. In addition, the effect of streamer polarity on the reduction of SO2 and NO was investigated in detail. The experimental results show that the corona wind formed between the high-voltage needle electrode and the water by corona discharge enhances the cleaning efficiency of the flue gas because of the presence of water, and the cleaning efficiency will increase with the increase of applied dc voltage within a definite range. The removal efficiency of SO2 up to 98%, and about 85% of NOx removal under suitable conditions is obtained in our experiments.

  3. Constant-current corona triode adapted and optimized for the characterization of thin dielectric films

    NASA Astrophysics Data System (ADS)

    Giacometti, José A.

    2018-05-01

    This work describes an enhanced corona triode with constant current adapted to characterize the electrical properties of thin dielectric films used in organic electronic devices. A metallic grid with a high ionic transparency is employed to charge thin films (100 s of nm thick) with a large enough charging current. The determination of the surface potential is based on the grid voltage measurement, but using a more sophisticated procedure than the previous corona triode. Controlling the charging current to zero, which is the open-circuit condition, the potential decay can be measured without using a vibrating grid. In addition, the electric capacitance and the characteristic curves of current versus the stationary surface potential can also be determined. To demonstrate the use of the constant current corona triode, we have characterized poly(methyl methacrylate) thin films with films with thicknesses in the range from 300 to 500 nm, frequently used as gate dielectric in organic field-effect transistors.

  4. Incremental short daily home hemodialysis: a case series.

    PubMed

    Toth-Manikowski, Stephanie M; Mullangi, Surekha; Hwang, Seungyoung; Shafi, Tariq

    2017-07-05

    Patients starting dialysis often have substantial residual kidney function. Incremental hemodialysis provides a hemodialysis prescription that supplements patients' residual kidney function while maintaining total (residual + dialysis) urea clearance (standard Kt/Vurea) targets. We describe our experience with incremental hemodialysis in patients using NxStage System One for home hemodialysis. From 2011 to 2015, we initiated 5 incident hemodialysis patients on an incremental home hemodialysis regimen. The biochemical parameters of all patients remained stable on the incremental hemodialysis regimen and they consistently achieved standard Kt/Vurea targets. Of the two patients with follow-up >6 months, residual kidney function was preserved for ≥2 years. Importantly, the patients were able to transition to home hemodialysis without automatically requiring 5 sessions per week at the outset and gradually increased the number of treatments and/or dialysate volume as the residual kidney function declined. An incremental home hemodialysis regimen can be safely prescribed and may improve acceptability of home hemodialysis. Reducing hemodialysis frequency by even one treatment per week can reduce the number of fistula or graft cannulations or catheter connections by >100 per year, an important consideration for patient well-being, access longevity, and access-related infections. The incremental hemodialysis approach, supported by national guidelines, can be considered for all home hemodialysis patients with residual kidney function.

  5. Kinetically driven self-assembly of a binary solute mixture with controlled phase separation via electro-hydrodynamic flow of corona discharge.

    PubMed

    Jung, Hee Joon; Huh, June; Park, Cheolmin

    2012-10-21

    This feature article describes a new and facile process to fabricate a variety of thin films of non-volatile binary solute mixtures suitable for high performance organic electronic devices via electro-hydrodynamic flow of conventional corona discharge. Both Corona Discharge Coating (CDC) and a modified version of CDC, Scanning Corona Discharge Coating (SCDC), are based on utilizing directional electric flow, known as corona wind, of the charged uni-polar particles generated by corona discharge between a metallic needle and a bottom plate under a high electric field (5-10 kV cm(-1)). The electric flow rapidly spreads out the binary mixture solution on the bottom plate and subsequently forms a smooth and flat thin film in a large area within a few seconds. In the case of SCDC, the static movement of the bottom electrode on which a binary mixture solution is placed provides further control of thin film formation, giving rise to a film highly uniform over a large area. Interesting phase separation behaviors were observed including nanometer scale phase separation of a polymer-polymer binary mixture and vertical phase separation of a polymer-organic semiconductor mixture. Core-shell type phase separation of either polymer-polymer or polymer-colloidal nanoparticle binary mixtures was also developed with a periodically patterned microstructure when the relative location of the corona wind was controlled to a binary solution droplet on a substrate. We also demonstrate potential applications of thin functional films with controlled microstructures by corona coating to various organic electronic devices such as electroluminescent diodes, field effect transistors and non-volatile polymer memories.

  6. Kinetically driven self-assembly of a binary solute mixture with controlled phase separation via electro-hydrodynamic flow of corona discharge

    NASA Astrophysics Data System (ADS)

    Jung, Hee Joon; Huh, June; Park, Cheolmin

    2012-09-01

    This feature article describes a new and facile process to fabricate a variety of thin films of non-volatile binary solute mixtures suitable for high performance organic electronic devices via electro-hydrodynamic flow of conventional corona discharge. Both Corona Discharge Coating (CDC) and a modified version of CDC, Scanning Corona Discharge Coating (SCDC), are based on utilizing directional electric flow, known as corona wind, of the charged uni-polar particles generated by corona discharge between a metallic needle and a bottom plate under a high electric field (5-10 kV cm-1). The electric flow rapidly spreads out the binary mixture solution on the bottom plate and subsequently forms a smooth and flat thin film in a large area within a few seconds. In the case of SCDC, the static movement of the bottom electrode on which a binary mixture solution is placed provides further control of thin film formation, giving rise to a film highly uniform over a large area. Interesting phase separation behaviors were observed including nanometer scale phase separation of a polymer-polymer binary mixture and vertical phase separation of a polymer-organic semiconductor mixture. Core-shell type phase separation of either polymer-polymer or polymer-colloidal nanoparticle binary mixtures was also developed with a periodically patterned microstructure when the relative location of the corona wind was controlled to a binary solution droplet on a substrate. We also demonstrate potential applications of thin functional films with controlled microstructures by corona coating to various organic electronic devices such as electroluminescent diodes, field effect transistors and non-volatile polymer memories.

  7. Effect of dosage increments on blood phenytoin concentrations

    PubMed Central

    Bochner, F.; Hooper, W. D.; Tyrer, J. H.; Eadie, M. J.

    1972-01-01

    Blood phenytoin (diphenylhydantoin) concentrations were measured after each dosage change in 12 epileptic patients who were given increasing oral doses of phenytoin. In each of these patients a dosage increment beyond the dosage that produced a blood phenytoin level of 6-9 μg/ml. caused a disproportionately great increase in the blood concentration of drug. This effect might be expected if the limit of the body's capacity to metabolize phenytoin were being reached. As oral dosages were increased in one patient, measurements of the rate of urinary excretion of phenytoin metabolite showed that the phase of rapid rise in blood phenytoin concentration coincided with a failure to increase the rate of phenytoin metabolite excretion. Awareness of the non-linear relation between oral dose and blood concentration of phenytoin in the individual patient, and realization that the phase of rapid rise in blood phenytoin concentration occurs through the `therapeutic' range of 10-20 μg/ml., is of importance to those who use blood phenytoin levels as a guide to the adequacy of anticonvulsant therapy. PMID:4647859

  8. Double Compton and Cyclo-Synchrotron in Super-Eddington Discs, Magnetized Coronae, and Jets

    NASA Astrophysics Data System (ADS)

    McKinney, Jonathan C.; Chluba, Jens; Wielgus, Maciek; Narayan, Ramesh; Sadowski, Aleksander

    2017-05-01

    Black hole accretion discs accreting near the Eddington rate are dominated by bremsstrahlung cooling, but above the Eddington rate, the double Compton process can dominate in radiation-dominated regions, while the cyclo-synchrotron can dominate in strongly magnetized regions like a corona or a jet. We present an extension to the general relativistic radiation magnetohydrodynamic code harmrad to account for emission and absorption by thermal cyclo-synchrotron, double Compton, bremsstrahlung, low-temperature opal opacities, as well as Thomson and Compton scattering. The harmrad code and associated analysis and visualization codes have been made open-source and are publicly available at the github repository website. We approximate the radiation field as a Bose-Einstein distribution and evolve it using the radiation number-energy-momentum conservation equations in order to track photon hardening. We perform various simulations to study how these extensions affect the radiative properties of magnetically arrested discs accreting at Eddington to super-Eddington rates. We find that double Compton dominates bremsstrahlung in the disc within a radius of r ˜ 15rg (gravitational radii) at hundred times the Eddington accretion rate, and within smaller radii at lower accretion rates. Double Compton and cyclo-synchrotron regulate radiation and gas temperatures in the corona, while cyclo-synchrotron regulates temperatures in the jet. Interestingly, as the accretion rate drops to Eddington, an optically thin corona develops whose gas temperature of T ˜ 109K is ˜100 times higher than the disc's blackbody temperature. Our results show the importance of double Compton and synchrotron in super-Eddington discs, magnetized coronae and jets.

  9. A search at two eclipses for short-period waves that heat the corona

    NASA Astrophysics Data System (ADS)

    Pasachoff, Jay M.; Babcock, Bryce A.; Russell, Kevin D.; McConnochie, Timothy H.; Diaz, J. Sebastian

    2000-08-01

    As part of a study of the cause of solar coronal heating, we searched for high-frequency (~1 Hz) intensity oscillations in coronal loops in the [Fexiv] coronal green line. We summarize results from observations made at the 3 November 1994, total solar eclipse from the International Astronomical Union site in Putre, Chile, through partly cloudy skies, and at the 26 February 1998 total solar eclipse from Nord, Aruba, through clear skies. We discuss the image reduction and analysis of two simultaneous series of coronal CCD images digitized at 10 Hz for a total time of 160 s in Chile. One series of images was taken through a filter isolating the 5303 Å[Fexiv] coronal green line and the other through a 100 Å filter in the nearby K-corona continuum. We then discuss the modifications made for the 1998 eclipse, and the image reduction and analysis for those image sequences. After standard calibrations and image alignment of both data sets, we use Fourier analysis to search in the [Fexiv] channel for intensity oscillations in loops at the base of the corona. Such oscillations in the 1-Hz range are predicted as a result of density fluctuations from the resonant absorption of MHD waves. The dissipation of a significant amount of mechanical energy from the photosphere into the corona through this mechanism could provide sufficient energy to heat the corona. At neither eclipse do we find evidence for oscillations in the [Fexiv] green line at a level greater than 2% of coronal intensity.

  10. Optical emission spectroscopy of point-plane corona and back-corona discharges in air

    NASA Astrophysics Data System (ADS)

    Czech, T.; Sobczyk, A. T.; Jaworek, A.

    2011-12-01

    Results of spectroscopic investigations and current-voltage characteristics of corona discharge and back discharge on fly-ash layer, generated in point-plane electrode geometry in air at atmospheric pressure are presented in the paper. The characteristics of both discharges are similar but differ in the current and voltage ranges of all the discharge forms distinguished during the experiments. Three forms of back discharge, for positive and negative polarity, were investigated: glow, streamer and low-current back-arc. In order to characterize ionisation and excitation processes in back discharge, the emission spectra were measured and compared with those obtained for normal corona discharge generated in the same electrode configuration but with fly ash layer removed. The emission spectra were measured in two discharge zones: near the tip of needle electrode and near the plate. Visual forms of the discharge were recorded with digital camera and referred to current-voltage characteristics and emission spectra. The measurements have shown that spectral lines emitted by back discharge depend on the form of discharge and the discharge current. From the comparison of the spectral lines of back and normal discharges an effect of fly ash layer on the discharge morphology can be determined. The recorded emission spectra formed by ionised gas and plasma near the needle electrode and fly ash layer are different. It should be noted that in back arc emission, spectral lines of fly ash layer components can be distinguished. On the other hand, in needle zone, the emission of high intensity N2 second positive system and NO γ lines can be noticed. Regardless of these gaseous lines, also atomic lines of dust layer were present in the spectrum. The differences in spectra of back discharge for positive and negative polarities of the needle electrode have been explained by considering the kind of ions generated in the crater in fly ash layer. The aim of these studies is to better

  11. HERCULES X-1: USING ECLIPSE TO MEASURE THE X-RAY CORONA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leahy, D. A.

    Observations of HZ Her/Her X-1 by the Rossi X-ray Timing Explorer during High State X-ray eclipses are analyzed. After a sharp ingress caused by the neutron star receding behind the companion star HZ Her, X-ray flux smoothly declines to a minimum at mid-eclipse. It then increases smoothly until egress. The mid-eclipse flux implies an extended emission region around the neutron star that is larger than that of HZ Her. The constancy of the X-ray softness ratio is consistent with electron scattering by an ionized corona. The corona is modeled as spherically symmetric with a power-law density profile. We find amore » best fit of ∝r {sup –1.25} with a normalization of ≅ 10{sup 12} cm{sup –3} at r = 2 × 10{sup 10} cm. The corona could either be in hydrostatic equilibrium, with heating by Compton scattering, a fast outflow, with a high mass-loss rate of ∼10{sup 18} gm s{sup –1}, or a hybrid, with an inner hydrostatic region and outer slow flow with a low mass-loss rate. A brightening at orbital phase 0.94 is suggested to be caused by the impact of the accretion stream with the accretion disk.« less

  12. Time-lag properties of corona streamer discharges between impulse sphere and dc needle electrodes under atmospheric air conditions.

    PubMed

    Okano, Daisuke

    2013-02-01

    In this study of corona streamer discharges from an impulse generator using a dc power supply, the relationship of the discharge time-lag with the dc bias voltage between the sphere-to-needle electrodes under atmospheric conditions is investigated. Devices utilizing corona discharges have been used to purify air or water, destroy bacteria, and to remove undesirable substances, and in order to achieve fast response times and high power efficiencies in such devices, it is important to minimize the time-lag of the corona discharge. Our experimental results show that (a) the discharge path of a negatively biased needle electrode will be straighter than that of a positively biased needle and (b) the discharge threshold voltage in both the positive and the negative needle electrodes is nearly equal to 33 kV. By expressing the discharge voltage as a power function of time-lag, the extent of corona generation can be quantitatively specified using the exponent of this power function. The observed behavior of a corona streamer discharge between the negative spherical and the positive needle electrodes indicates that the largest power exponent is associated with the shortest time-lag, owing to the reduction in the statistical time-lag in the absence of a formative time-lag.

  13. Time-lag properties of corona streamer discharges between impulse sphere and dc needle electrodes under atmospheric air conditions

    NASA Astrophysics Data System (ADS)

    Okano, Daisuke

    2013-02-01

    In this study of corona streamer discharges from an impulse generator using a dc power supply, the relationship of the discharge time-lag with the dc bias voltage between the sphere-to-needle electrodes under atmospheric conditions is investigated. Devices utilizing corona discharges have been used to purify air or water, destroy bacteria, and to remove undesirable substances, and in order to achieve fast response times and high power efficiencies in such devices, it is important to minimize the time-lag of the corona discharge. Our experimental results show that (a) the discharge path of a negatively biased needle electrode will be straighter than that of a positively biased needle and (b) the discharge threshold voltage in both the positive and the negative needle electrodes is nearly equal to 33 kV. By expressing the discharge voltage as a power function of time-lag, the extent of corona generation can be quantitatively specified using the exponent of this power function. The observed behavior of a corona streamer discharge between the negative spherical and the positive needle electrodes indicates that the largest power exponent is associated with the shortest time-lag, owing to the reduction in the statistical time-lag in the absence of a formative time-lag.

  14. Exploring dynamic events in the solar corona

    NASA Astrophysics Data System (ADS)

    Downs, Cooper James

    With the advent of modern computational technology it is now becoming the norm to employ detailed 3D computer models as empirical tools that directly account for the inhomogeneous nature of the Sun-Heliosphere environment. The key advantage of this approach lies in the ability to compare model results directly to observational data and to use a successful comparison (or lack thereof) to glean information on the underlying physical processes. Using extreme ultraviolet waves (EUV waves) as the overarching scientific driver, we apply this observation modeling approach to study the complex dynamics of the magnetic and thermodynamic structures that are observed in the low solar corona. Representing a highly non-trivial effort, this work includes three main scientific thrusts: an initial modeling effort and two EUV wave case-studies. First we document the development of the new Low Corona (LC) model, a 3D time-dependent thermodynamic magnetohydrodynamic (MHD) model implemented within the Space Weather Modeling Framework (SWMF). Observation synthesis methods are integrated within the LC model, which provides the ability to compare model results directly to EUV imaging observations taken by spacecraft. The new model is then used to explore the dynamic interplay between magnetic structures and thermodynamic energy balance in the corona that is caused by coronal heating mechanisms. With the model development complete, we investigate the nature of EUV waves in detail through two case-studies. Starting with the 2008 March 25 event, we conduct a series of numerical simulations that independently vary fundamental parameters thought to govern the physical mechanisms behind EUV waves. Through the subsequent analysis of the 3D data and comparison to observations we find evidence for both wave and non-wave mechanisms contributing to the EUV wave signal. We conclude with a comprehensive observation and modeling analysis of the 2010 June 13 EUV wave event, which was observed by the

  15. The EUV Emission in Comet-Solar Corona Interactions

    NASA Technical Reports Server (NTRS)

    Bryans, Paul; Pesnell, William Dean; Schrijver, Carolus J.; Brown, John C.; Battams, Karl; Saint-Hilaire, Pasal; Liu, Wei; Hudson, Hugh S.

    2011-01-01

    The Atmospheric Imaging Assembly (AlA) on the Solar Dynamics Observatory (SDO) viewed a comet as it passed through the solar corona on 2011 July 5. This was the first sighting of a comet by a EUV telescope. For 20 minutes, enhanced emission in several of the AlA wavelength bands marked the path of the comet. We explain this EUV emission by considering the evolution of the cometary atmosphere as it interacts with the ambient solar atmosphere. Water ice in the comet rapidly sublimates as it approaches the Sun. This water vapor is then photodissociated, primarily by Ly-alpha, by the solar radiation field to create atomic Hand O. Other molecules present in the comet also evaporate and dissociate to give atomic Fe and other metals. Subsequent ionization of these atoms can be achieved by a number of means, including photoionization, electron impact, and charge exchange with coronal protons and other highly-charged species. Finally, particles from the cometary atmosphere are thermalized to the background temperature of the corona. Each step could cause emission in the AlA bandpasses. We will report here on their relative contribution to the emission seen in the AlA telescopes.

  16. JET PROPERTIES OF GeV-SELECTED RADIO-LOUD NARROW-LINE SEYFERT 1 GALAXIES AND POSSIBLE CONNECTION TO THEIR DISK AND CORONA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sun, Xiao-Na; Lin, Da-Bin; Liang, En-Wei

    The observed spectral energy distributions of five GeV-selected narrow-line Seyfert 1 (NLS1) galaxies are fitted with a model including the radiation ingredients from the relativistic jet, the accretion disk, and the corona. We compare the properties of these GeV NLS1 galaxies with flat spectrum radio quasars (FSRQs), BL Lacertae objects (BL Lacs), and radio-quiet (RQ) Seyfert galaxies, and explore possible hints for jet-disk/corona connection. Our results show that the radiation physics and the jet properties of the GeV NLS1 galaxies resemble that of FSRQs. The luminosity variations of PMN J0948+0022 and 1H 0323+342 at the GeV band is tightly correlatedmore » with the beaming factor (δ), similar to that observed in FSRQ 3C 279. The accretion disk luminosities and the jet powers of the GeV NLS1 galaxies cover both the ranges of FSRQs and BL Lacs. With the detection of bright corona emission in 1H 0323+342, we show that the ratio of the corona luminosity (L {sub corona}) to the accretion disk luminosity (L {sub d}) is marginally within the high end of this ratio distribution for an RQ Seyfert galaxy sample, and the variation of jet luminosity may connect with L {sub corona}. However, it is still unclear whether a system with a high L {sub corona}/L {sub d} ratio prefers to power a jet.« less

  17. Formation and Reconnection of Three-Dimensional Current Sheets in the Solar Corona

    NASA Technical Reports Server (NTRS)

    Edmondson, J. K.; Antiochos, S. K.; DeVore, C. R.; Zurbuchen, T. H.

    2010-01-01

    Current-sheet formation and magnetic reconnection are believed to be the basic physical processes responsible for much of the activity observed in astrophysical plasmas, such as the Sun s corona. We investigate these processes for a magnetic configuration consisting of a uniform background field and an embedded line dipole, a topology that is expected to be ubiquitous in the corona. This magnetic system is driven by a uniform horizontal flow applied at the line-tied photosphere. Although both the initial field and the driver are translationally symmetric, the resulting evolution is calculated using a fully three-dimensional magnetohydrodynamic (3D MHD) simulation with adaptive mesh refinement that resolves the current sheet and reconnection dynamics in detail. The advantage of our approach is that it allows us to apply directly the vast body of knowledge gained from the many studies of 2D reconnection to the fully 3D case. We find that a current sheet forms in close analogy to the classic Syrovatskii 2D mechanism, but the resulting evolution is different than expected. The current sheet is globally stable, showing no evidence for a disruption or a secondary instability even for aspect ratios as high as 80:1. The global evolution generally follows the standard Sweet- Parker 2D reconnection model except for an accelerated reconnection rate at a very thin current sheet, due to the tearing instability and the formation of magnetic islands. An interesting conclusion is that despite the formation of fully 3D structures at small scales, the system remains close to 2D at global scales. We discuss the implications of our results for observations of the solar corona. Subject Headings: Sun: corona Sun: magnetic fields Sun: reconnection

  18. Observation of Alfven Waves in the Solar Corona (Invited)

    NASA Astrophysics Data System (ADS)

    Tomczyk, S.

    2013-12-01

    I will review the extensive progress made in recent years on the observation of Alfven waves in the solar corona, with an emphasis on the measurements made with the Coronal Multi-channel Polarimeter. Application of the wave measurements to coronal seismology will be presented. Future prospects in the field will be discussed.

  19. Incremental burden of congestive heart failure among elderly with Alzheimer's.

    PubMed

    Chhatre, Sumedha; Weiner, Mark G; Jayadevappa, Ravishankar; Johnson, Jerry C

    2009-07-01

    A complex relationship exists between Alzheimer's disease (AD) and other co-existing co-morbidities such as congestive heart failure (CHF) with implications for health resource utilization (HRU) and cost of care. Study objective was to assess HRU and cost of care in elderly with AD and with or without concomitant CHF. All elderly (> or =65 years) from an academic healthcare system diagnosed with AD in 1999 (n = 904) and matched AD-free controls (n = 3616). Each group was subdivided into those with and without a CHF diagnosis. Costs and HRU were obtained from Medicare databases for 1999 and 2000. Costs and HRU were compared using ANOVA and Wilcoxon rank sum tests. Regressions were used to model the effect of AD and CHF on outcomes. Mean annual cost were 20,888 US dollars for AD + CHF group, 5,473 US dollars for only AD group, 17,700 US dollars for only CHF group and 4,578 US dollars for the control group (no-AD and no-CHF). After adjusting for covariates, AD + CHF group had an eight-fold increase in total cost, while only CHF group had five-fold increase in total cost, compared to the control group. Regressions for inpatient costs, outpatient costs and inpatient pharmacy costs exhibited comparable trends. For elderly AD patients, a co-occurring diagnosis of CHF can result in a substantial increase in cost and HRU. This necessitates additional considerations if health care expenditures are to be reduced, particularly inpatient expenditure.

  20. The incremental impact of cardiac MRI on clinical decision-making.

    PubMed

    Rajwani, Adil; Stewart, Michael J; Richardson, James D; Child, Nicholas M; Maredia, Neil

    2016-01-01

    Despite a significant expansion in the use of cardiac MRI (CMR), there is inadequate evaluation of its incremental impact on clinical decision-making over and above other well-established modalities. We sought to determine the incremental utility of CMR in routine practice. 629 consecutive CMR studies referred by 44 clinicians from 9 institutions were evaluated. Pre-defined algorithms were used to determine the incremental influence on diagnostic thinking, influence on clinical management and thus the overall clinical utility. Studies were also subdivided and evaluated according to the indication for CMR. CMR provided incremental information to the clinician in 85% of cases, with incremental influence on diagnostic thinking in 85% of cases and incremental impact on management in 42% of cases. The overall incremental utility of CMR exceeded 90% in 7 out of the 13 indications, whereas in settings such as the evaluation of unexplained ventricular arrhythmia or mild left ventricular systolic dysfunction, this was <50%. CMR was frequently able to inform and influence decision-making in routine clinical practice, even with analyses that accepted only incremental clinical information and excluded a redundant duplication of imaging. Significant variations in yield were noted according to the indication for CMR. These data support a wider integration of CMR services into cardiac imaging departments. These data are the first to objectively evaluate the incremental value of a UK CMR service in clinical decision-making. Such data are essential when seeking justification for a CMR service.