The MUSE view of the host galaxy of GRB 100316D

NASA Astrophysics Data System (ADS)

Izzo, L.; Thöne, C. C.; Schulze, S.; Mehner, A.; Flores, H.; Cano, Z.; de Ugarte Postigo, A.; Kann, D. A.; Amorín, R.; Anderson, J. P.; Bauer, F. E.; Bensch, K.; Christensen, L.; Covino, S.; Della Valle, M.; Fynbo, J. P. U.; Jakobsson, P.; Klose, S.; Kuncarayakti, H.; Leloudas, G.; Milvang-Jensen, B.; Møller, P.; Puech, M.; Rossi, A.; Sánchez-Ramírez, R.; Vergani, S. D.

2017-12-01

The low distance, z = 0.0591, of GRB 100316D and its association with SN 2010bh represent two important motivations for studying this host galaxy and the GRB's immediate environment with the integral field spectrographs like Very Large Telescope/Multi-Unit Spectroscopic Explorer. Its large field of view allows us to create 2D maps of gas metallicity, ionization level and the star formation rate (SFR) distribution maps, as well as to investigate the presence of possible host companions. The host is a late-type dwarf irregular galaxy with multiple star-forming regions and an extended central region with signatures of on-going shock interactions. The gamma-ray burst (GRB) site is characterized by the lowest metallicity, the highest SFR and the youngest (∼20-30 Myr) stellar population in the galaxy, which suggest a GRB progenitor stellar population with masses up to 20-40 M⊙. We note that the GRB site has an offset of ∼660 pc from the most luminous SF region in the host. The observed SF activity in this galaxy may have been triggered by a relatively recent gravitational encounter between the host and a small undetected (LH α ≤ 1036 erg s-1) companion.

Investigating a population of infrared-bright gamma-ray burst host galaxies

NASA Astrophysics Data System (ADS)

Chrimes, Ashley A.; Stanway, Elizabeth R.; Levan, Andrew J.; Davies, Luke J. M.; Angus, Charlotte R.; Greis, Stephanie M. L.

2018-07-01

We identify and explore the properties of an infrared-bright gamma-ray burst (GRB) host population. Candidate hosts are selected by coincidence with sources in WISE, with matching to random coordinates and a false alarm probability analysis showing that the contamination fraction is ˜0.5. This methodology has already identified the host galaxy of GRB 080517. We combine survey photometry from Pan-STARRS, SDSS, APASS, 2MASS, GALEX, and WISE with our own WHT/ACAM and VLT/X-shooter observations to classify the candidates and identify interlopers. Galaxy SED fitting is performed using MAGPHYS, in addition to stellar template fitting, yielding 13 possible IR-bright hosts. A further seven candidates are identified from the previously published work. We report a candidate host for GRB 061002, previously unidentified as such. The remainder of the galaxies have already been noted as potential hosts. Comparing the IR-bright population properties including redshift z, stellar mass M⋆, star formation rate SFR, and V-band attenuation AV to GRB host catalogues in the literature, we find that the infrared-bright population is biased towards low z, high M⋆, and high AV. This naturally arises from their initial selection - local and dusty galaxies are more likely to have the required IR flux to be detected in WISE. We conclude that while IR-bright GRB hosts are not a physically distinct class, they are useful for constraining existing GRB host populations, particularly for long GRBs.

Investigating a population of infrared-bright gamma-ray burst host galaxies

NASA Astrophysics Data System (ADS)

Chrimes, Ashley A.; Stanway, Elizabeth R.; Levan, Andrew J.; Davies, Luke J. M.; Angus, Charlotte R.; Greis, Stephanie M. L.

2018-04-01

We identify and explore the properties of an infrared-bright gamma-ray burst (GRB) host population. Candidate hosts are selected by coincidence with sources in WISE, with matching to random coordinates and a false alarm probability analysis showing that the contamination fraction is ˜ 0.5. This methodology has already identified the host galaxy of GRB 080517. We combine survey photometry from Pan-STARRS, SDSS, APASS, 2MASS, GALEX and WISE with our own WHT/ACAM and VLT/X-shooter observations to classify the candidates and identify interlopers. Galaxy SED fitting is performed using MAGPHYS, in addition to stellar template fitting, yielding 13 possible IR-bright hosts. A further 7 candidates are identified from previously published work. We report a candidate host for GRB 061002, previously unidentified as such. The remainder of the galaxies have already been noted as potential hosts. Comparing the IR-bright population properties including redshift z, stellar mass M⋆, star formation rate SFR and V-band attenuation AV to GRB host catalogues in the literature, we find that the infrared-bright population is biased toward low z, high M⋆ and high AV. This naturally arises from their initial selection - local and dusty galaxies are more likely to have the required IR flux to be detected in WISE. We conclude that while IR-bright GRB hosts are not a physically distinct class, they are useful for constraining existing GRB host populations, particularly for long GRBs.

The Swift GRB Host Galaxy Legacy Survey

NASA Astrophysics Data System (ADS)

Perley, Daniel

2015-08-01

I will describe the Swift Host Galaxy Legacy Survey (SHOALS), a comprehensive multiwavelength program to characterize the demographics of the GRB host population and its redshift evolution from z=0 to z=7. Using unbiased selection criteria we have designated a subset of 119 Swift gamma-ray bursts which are now being targeted with intensive observational follow-up. Deep Spitzer imaging of every field has already been obtained and analyzed, with major programs ongoing at Keck, GTC, Gemini, VLT, and Magellan to obtain complementary optical/NIR photometry and spectroscopy to enable full SED modeling and derivation of fundamental physical parameters such as mass, extinction, and star-formation rate. Using these data I will present an unbiased measurement of the GRB host-galaxy luminosity and mass distributions and their evolution with redshift, compare GRB hosts to other star-forming galaxy populations, and discuss implications for the nature of the GRB progenitor and the ability of GRBs to serve as tools for measuring and studying cosmic star-formation in the distant universe.

Missing GRB host galaxies in deep mid-infrared observations: implications on the use of GRBs as star formation tracers

NASA Astrophysics Data System (ADS)

Le Floc'h, Emeric; Charmandaris, Vassilis; Forrest, Bill; Mirabel, Félix; Armus, Lee; Devost, Daniel

2006-05-01

We report on the first mid-infrared observations of 16 GRB host galaxies performed with the Spitzer Space Telescope, and investigate the presence of evolved stellar populations and dust-enshrouded star-forming activity associated with GRBs. Only a very small fraction of our sample is detected by Spitzer, which is not consistent with recent works suggesting the presence of a GRB host population dominated by massive and strongly-starbursting galaxies (SFR >~ 100Msolaryr-1). Should the GRB hosts be representative of star-forming galaxies at high redshift, models of galaxy evolution indicate that >~ 50% of GRB hosts would be easily detected at the depth of our mid-infrared observations. Unless our sample suffers from a strong observational bias which remains to be understood, we infer in this context that the GRBs identified with the current techniques can not be directly used as unbiased probes of the global and integrated star formation history of the Universe.

Long-Duration Gamma-Ray Burst Host Galaxies in Emission and Absorption

NASA Astrophysics Data System (ADS)

Perley, Daniel A.; Niino, Yuu; Tanvir, Nial R.; Vergani, Susanna D.; Fynbo, Johan P. U.

2016-12-01

The galaxy population hosting long-duration GRBs provides a means to constrain the progenitor and an opportunity to use these violent explosions to characterize the nature of the high-redshift universe. Studies of GRB host galaxies in emission reveal a population of star-forming galaxies with great diversity, spanning a wide range of masses, metallicities, and redshifts. However, as a population GRB hosts are significantly less massive and poorer in metals than the hosts of other core-collapse transients, suggesting that GRB production is only efficient at metallicities significantly below Solar. GRBs may also prefer compact galaxies, and dense and/or central regions of galaxies, more than other types of core-collapse explosion. Meanwhile, studies of hosts in absorption against the luminous GRB optical afterglow provide a unique means of unveiling properties of the ISM in even the faintest and most distant galaxies; these observations are helping to constrain the chemical evolution of galaxies and the properties of interstellar dust out to very high redshifts. New ground- and space-based instrumentation, and the accumulation of larger and more carefully-selected samples, are continually enhancing our view of the GRB host population.

The SEDs and Host Galaxies of the Dustiest GRB Afterglows

NASA Technical Reports Server (NTRS)

Kruhler, T.; Greiner, J.; Schady, P.; Savaglio, S.; Afonso, P. M. J.; Clemens, C.; Elliott, J.; Filgas, R.; Gruber, D.; Kann, D. A.;

GRB host galaxies with VLT/X-Shooter: properties at 0.8 < z < 1.3

NASA Astrophysics Data System (ADS)

Piranomonte, S.; Japelj, J.; Vergani, S. D.; Savaglio, S.; Palazzi, E.; Covino, S.; Flores, H.; Goldoni, P.; Cupani, G.; Krühler, T.; Mannucci, F.; Onori, F.; Rossi, A.; D'Elia, V.; Pian, E.; D'Avanzo, P.; Gomboc, A.; Hammer, F.; Randich, S.; Fiore, F.; Stella, L.; Tagliaferri, G.

2015-10-01

Long gamma-ray bursts (LGRBs) are associated with the death of massive stars. Their host galaxies therefore represent a unique class of objects tracing star formation across the observable Universe. Indeed, recently accumulated evidence shows that GRB hosts do not differ substantially from general population of galaxies at high (z > 2) redshifts. However, it has been long recognized that the properties of z < 1.5 hosts, compared to general star-forming population, are unusual. To better understand the reasons for the supposed difference in LGRB hosts properties at z < 1.5, we obtained Very Large Telescope (VLT)/X-Shooter spectra of six hosts lying in the redshift range of 0.8 < z < 1.3. Some of these hosts have been observed before, yet we still lack well-constrained information on their characteristics such as metallicity, dust extinction and star formation rate (SFR). We search for emission lines in the VLT/X-Shooter spectra of the hosts and measure their fluxes. We perform a detailed analysis, estimating host average extinction, SFRs, metallicities and electron densities where possible. Measured quantities of our hosts are compared to a larger sample of previously observed GRB hosts at z < 2. SFRs and metallicities are measured for all the hosts analysed in this paper and metallicities are well determined for four hosts. The mass-metallicity relation, the fundamental metallicity relation and SFRs derived from our hosts occupy similar parameter space as other host galaxies investigated so far at the same redshift. We therefore conclude that GRB hosts in our sample support the found discrepancy between the properties of low-redshift GRB hosts and the general population of star-forming galaxies.

Unveiling the Secrets of Metallicity and Massive Star Formation Using DLAs Along Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Cucchiara, A.; Fumagalli, M.; Rafelski, M.; Kocevski, D.; Prochaska, J. X.; Cooke, R. J.; Becker, G. D.

2015-01-01

We present the largest, publicly available, sample of Damped Lyman-alpha systems (DLAs) along Swift discovered Gamma-ray Bursts (GRB) line of sights in order to investigate the environmental properties of long GRB hosts in the z = 1.8 - 6 redshift range. Compared with the most recent quasar DLAs sample (QSO-DLA), our analysis shows that GRB-DLAs probe a more metal enriched environment at z approximately greater than 3, up to [X/H] approximately -0.5. In the z = 2 - 3 redshift range, despite the large number of lower limits, there are hints that the two populations may be more similar (only at 90% significance level) than at higher redshifts. Also, at high-z, the GRB-DLA average metallicity seems to decline at a shallower rate than the QSO-DLAs: GRB-DLA hosts may be polluted with metals at least as far as approximately 2 kpc from the GRB explosion site, probably due to previous star-formation episodes and/or supernovae explosions. This shallow metallicity trend, extended now up to z approximately 5, confirms previous results that GRB hosts are star-forming and have, on average, higher metallicity than the general QSO-DLA population. Finally, our host metallicity measurements are broadly consistent with the predictions derived from the hypothesis of two channels of GRB progenitors, one of which is mildly affected by a metallicity bias, although more data are needed to constrain the models at z approximately greater than 4.

The luminous, massive and solar metallicity galaxy hosting the Swift γ-ray burst GRB 160804A at z = 0.737

NASA Astrophysics Data System (ADS)

Heintz, K. E.; Malesani, D.; Wiersema, K.; Jakobsson, P.; Fynbo, J. P. U.; Savaglio, S.; Cano, Z.; Covino, S.; D'Elia, V.; Gomboc, A.; Hammer, F.; Kaper, L.; Milvang-Jensen, B.; Møller, P.; Piranomonte, S.; Selsing, J.; Rhodin, N. H. P.; Tanvir, N. R.; Thöne, C. C.; de Ugarte Postigo, A.; Vergani, S. D.; Watson, D.

2018-02-01

We here present the spectroscopic follow-up observations with VLT/X-shooter of the Swift long-duration gamma-ray burst GRB 160804A at z = 0.737. Typically, GRBs are found in low-mass, metal-poor galaxies that constitute the sub-luminous population of star-forming galaxies. For the host galaxy of the GRB presented here, we derive a stellar mass of log (M*/ M⊙) = 9.80 ± 0.07, a roughly solar metallicity (12 + log (O/H) = 8.74 ± 0.12) based on emission line diagnostics, and an infrared luminosity of M3.6/(1 + z) = -21.94 mag, but find it to be dust-poor (E(B - V) < 0.05 mag). This establishes the galaxy hosting GRB 160804A as one of the most luminous, massive and metal-rich GRB hosts at z < 1.5. Furthermore, the gas-phase metallicity is found to be representative of the physical conditions of the gas close to the explosion site of the burst. The high metallicity of the host galaxy is also observed in absorption, where we detect several strong Fe II transitions as well as Mg II and Mg I. Although host galaxy absorption features are common in GRB afterglow spectra, we detect absorption from strong metal lines directly in the host continuum (at a time when the afterglow was contributing to < 15 per cent). Finally, we discuss the possibility that the geometry and state of the absorbing and emitting gas are indicative of a galactic scale outflow expelled at the final stage of two merging galaxies.

Mass and metallicity scaling relations of high-redshift star-forming galaxies selected by GRBs

NASA Astrophysics Data System (ADS)

Arabsalmani, M.; Møller, P.; Perley, D. A.; Freudling, W.; Fynbo, J. P. U.; Le Floc'h, E.; Zwaan, M. A.; Schulze, S.; Tanvir, N. R.; Christensen, L.; Levan, A. J.; Jakobsson, P.; Malesani, D.; Cano, Z.; Covino, S.; D'Elia, V.; Goldoni, P.; Gomboc, A.; Heintz, K. E.; Sparre, M.; de Ugarte Postigo, A.; Vergani, S. D.

2018-01-01

We present a comprehensive study of the relations between gas kinematics, metallicity and stellar mass in a sample of 82 gamma-ray burst (GRB)-selected galaxies using absorption and emission methods. We find the velocity widths of both emission and absorption profiles to be a proxy of stellar mass. We also investigate the velocity-metallicity correlation and its evolution with redshift. Using 33 GRB hosts with measured stellar mass and metallicity, we study the mass-metallicity relation for GRB host galaxies in a stellar mass range of 108.2-1011.1 M⊙ and a redshift range of z ∼ 0.3-3.4. The GRB-selected galaxies appear to track the mass-metallicity relation of star-forming galaxies but with an offset of 0.15 towards lower metallicities. This offset is comparable with the average error bar on the metallicity measurements of the GRB sample and also the scatter on the mass-metallicity relation of the general population. It is hard to decide whether this relatively small offset is due to systematic effects or the intrinsic nature of GRB hosts. We also investigate the possibility of using absorption-line metallicity measurements of GRB hosts to study the mass-metallicity relation at high redshifts. Our analysis shows that the metallicity measurements from absorption methods can significantly differ from emission metallicities and assuming identical measurements from the two methods may result in erroneous conclusions.

A molecular gas-rich GRB host galaxy at the peak of cosmic star formation

NASA Astrophysics Data System (ADS)

Arabsalmani, M.; Le Floc'h, E.; Dannerbauer, H.; Feruglio, C.; Daddi, E.; Ciesla, L.; Charmandaris, V.; Japelj, J.; Vergani, S. D.; Duc, P.-A.; Basa, S.; Bournaud, F.; Elbaz, D.

2018-05-01

We report the detection of the CO(3-2) emission line from the host galaxy of gamma-ray burst (GRB) 080207 at z = 2.086. This is the first detection of molecular gas in emission from a GRB host galaxy beyond redshift 1. We find this galaxy to be rich in molecular gas with a mass of 1.1 × 10^{11} M_{{\\odot }} assuming αCO = 4.36 M_{{\\odot }} (K km s^{-1} pc^2)^{-1}. The molecular gas mass fraction of the galaxy is ˜0.5, typical of star-forming galaxies (SFGs) with similar stellar masses and redshifts. With an SFR_{FIR} of 260 M_{{\\odot }} yr^{-1}, we measure a molecular gas depletion time-scale of 0.43 Gyr, near the peak of the depletion time-scale distribution of SFGs at similar redshifts. Our findings are therefore in contradiction with the proposed molecular gas deficiency in GRB host galaxies. We argue that the reported molecular gas deficiency for GRB hosts could be the artefact of improper comparisons or neglecting the effect of the typical low metallicities of GRB hosts on the CO-to-molecular-gas conversion factor. We also compare the kinematics of the CO(3-2) emission line to that of the H α emission line from the host galaxy. We find the H α emission to have contributions from two separate components, a narrow and a broad one. The narrow component matches the CO emission well in velocity space. The broad component, with a full width at half-maximum of ˜1100 km s^{-1}, is separated by +390 km s^{-1} in velocity space from the narrow component. We speculate this broad component to be associated with a powerful outflow in the host galaxy or in an interacting system.

GRB 980425 host: [C II], [O I], and CO lines reveal recent enhancement of star formation due to atomic gas inflow

NASA Astrophysics Data System (ADS)

Michałowski, M. J.; Castro Cerón, J. M.; Wardlow, J. L.; Karska, A.; Messias, H.; van der Werf, P.; Hunt, L. K.; Baes, M.; Castro-Tirado, A. J.; Gentile, G.; Hjorth, J.; Le Floc'h, E.; Pérez-Martínez, R.; Nicuesa Guelbenzu, A.; Rasmussen, J.; Rizzo, J. R.; Rossi, A.; Sánchez-Portal, M.; Schady, P.; Sollerman, J.; Xu, D.

2016-11-01

Context. Accretion of gas from the intergalactic medium is required to fuel star formation in galaxies. We have recently suggested that this process can be studied using host galaxies of gamma-ray bursts (GRBs). Aims: Our aim is to test this possibility by studying in detail the properties of gas in the closest galaxy hosting a GRB (980425). Methods: We obtained the first ever far-infrared (FIR) line observations of a GRB host, namely Herschel/PACS resolved [C II] 158 μm and [O I] 63 μm spectroscopy, and an APEX/SHeFI CO(2-1) line detection and ALMA CO(1-0) observations of the GRB 980425 host. Results: The GRB 980425 host has elevated [C II]/FIR and [O I]/FIR ratios and higher values of star formation rates (SFR) derived from line ([C II], [O I], Hα) than from continuum (UV, IR, radio) indicators. [C II] emission exhibits a normal morphology, peaking at the galaxy centre, whereas [O I] is concentrated close to the GRB position and the nearby Wolf-Rayet region. The high [O I] flux indicates that there is high radiation field and high gas density at these positions, as derived from modelling of photo-dissociation regions. The [C II]/CO luminosity ratio of the GRB 980425 host is close to the highest values found for local star-forming galaxies. Indeed, its CO-derived molecular gas mass is low given its SFR and metallicity, but the [C II]-derived molecular gas mass is close to the expected value. Conclusions: The [O I] and H I concentrations and the high radiation field and density close to the GRB position are consistent with the hypothesis of a very recent (at most a few tens of Myr ago) inflow of atomic gas triggering star formation. In this scenario dust has not had time to build up (explaining high line-to-continuum ratios). Such a recent enhancement of star formation activity would indeed manifest itself in high SFRline/SFRcontinuum ratios because the line indicators are sensitive only to recent (≲10 Myr) activity, whereas the continuum indicators measure the SFR averaged over much longer periods ( 100 Myr). Within a sample of 32 other GRB hosts, 20 exhibit SFRline/SFRcontinuum> 1 with a mean ratio of 1.74 ± 0.32. This is consistent with a very recent enhancement of star formation that is common among GRB hosts, so galaxies that have recently experienced inflow of gas may preferentially host stars exploding as GRBs. Therefore GRBs may be used to select a unique sample of galaxies that is suitable for the investigation of recent gas accretion. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.

THE SWIFT GRB HOST GALAXY LEGACY SURVEY. II. REST-FRAME NEAR-IR LUMINOSITY DISTRIBUTION AND EVIDENCE FOR A NEAR-SOLAR METALLICITY THRESHOLD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perley, D. A.; Tanvir, N. R.; Hjorth, J.

2016-01-20

We present rest-frame near-IR (NIR) luminosities and stellar masses for a large and uniformly selected population of gamma-ray burst (GRB) host galaxies using deep Spitzer Space Telescope imaging of 119 targets from the Swift GRB Host Galaxy Legacy Survey spanning 0.03 < z < 6.3, and we determine the effects of galaxy evolution and chemical enrichment on the mass distribution of the GRB host population across cosmic history. We find a rapid increase in the characteristic NIR host luminosity between z ∼ 0.5 and z ∼ 1.5, but little variation between z ∼ 1.5 and z ∼ 5. Dust-obscured GRBs dominate the massive host population but are only rarely seen associated withmore » low-mass hosts, indicating that massive star-forming galaxies are universally and (to some extent) homogeneously dusty at high redshift while low-mass star-forming galaxies retain little dust in their interstellar medium. Comparing our luminosity distributions with field surveys and measurements of the high-z mass–metallicity relation, our results have good consistency with a model in which the GRB rate per unit star formation is constant in galaxies with gas-phase metallicity below approximately the solar value but heavily suppressed in more metal-rich environments. This model also naturally explains the previously reported “excess” in the GRB rate beyond z ≳ 2; metals stifle GRB production in most galaxies at z < 1.5 but have only minor impact at higher redshifts. The metallicity threshold we infer is much higher than predicted by single-star models and favors a binary progenitor. Our observations also constrain the fraction of cosmic star formation in low-mass galaxies undetectable to Spitzer to be small at z < 4.« less

GRB 020410: A Gamma-ray burst afterglow discovered by its supernova light

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levan, Andrew; Nugent, Peter; Fruchter, Andrew

2004-03-19

We present the discovery and monitoring of the optical transient (OT) associated with GRB 020410. The fading OT was found by Hubble Space Telescope (HST) observations taken 28 and 65 days after burst at a position consistent with the X-ray afterglow. Subsequent re-examination of early ground based observations revealed that a faint OT was present 6 hours after burst, confirming the source association with GRB 020410. A deep non-detection after one week requires that the OT re-brightened between day 7 and day 28, and further late time HST data taken approximately 100 days after burst imply that it is verymore » red (F{sub nu} proportional to nu-2.7). We compare both the flux and color of the excess with supernova models and show that the data are best explained by the presence of a Type I b/c supernova at a redshift z approx. equal 0.5, which occurred roughly coincident with the day of GRB.« less

The bright optical afterglow of the nearby gamma-ray burst of 29 March 2003.

PubMed

Price, P A; Fox, D W; Kulkarni, S R; Peterson, B A; Schmidt, B P; Soderberg, A M; Yost, S A; Berger, E; Djorgovski, S G; Frail, D A; Harrison, F A; Sari, R; Blain, A W; Chapman, S C

2003-06-19

Past studies of cosmological gamma-ray bursts (GRBs) have been hampered by their extreme distances, resulting in faint afterglows. A nearby GRB could potentially shed much light on the origin of these events, but GRBs with a redshift z

An enigmatic long-lasting gamma-ray burst not accompanied by a bright supernova.

PubMed

Della Valle, M; Chincarini, G; Panagia, N; Tagliaferri, G; Malesani, D; Testa, V; Fugazza, D; Campana, S; Covino, S; Mangano, V; Antonelli, L A; D'Avanzo, P; Hurley, K; Mirabel, I F; Pellizza, L J; Piranomonte, S; Stella, L

2006-12-21

Gamma-ray bursts (GRBs) are short, intense flashes of soft gamma-rays coming from the distant Universe. Long-duration GRBs (those lasting more than approximately 2 s) are believed to originate from the deaths of massive stars, mainly on the basis of a handful of solid associations between GRBs and supernovae. GRB 060614, one of the closest GRBs discovered, consisted of a 5-s hard spike followed by softer, brighter emission that lasted for approximately 100 s (refs 8, 9). Here we report deep optical observations of GRB 060614 showing no emerging supernova with absolute visual magnitude brighter than M(V) = -13.7. Any supernova associated with GRB 060614 was therefore at least 100 times fainter, at optical wavelengths, than the other supernovae associated with GRBs. This demonstrates that some long-lasting GRBs can either be associated with a very faint supernova or produced by different phenomena.

First measurement of H I 21 cm emission from a GRB host galaxy indicates a post-merger system

NASA Astrophysics Data System (ADS)

Arabsalmani, Maryam; Roychowdhury, Sambit; Zwaan, Martin A.; Kanekar, Nissim; Michałowski, Michał J.

2015-11-01

We report the detection and mapping of atomic hydrogen in H I 21 cm emission from ESO 184-G82, the host galaxy of the gamma-ray burst 980425. This is the first instance where H I in emission has been detected from a galaxy hosting a gamma-ray burst (GRB). ESO 184-G82 is an isolated galaxy and contains a Wolf-Rayet region close to the location of the GRB and the associated supernova, SN 1998bw. This is one of the most luminous H II regions identified in the local Universe, with a very high inferred density of star formation. The H I 21 cm observations reveal a high H I mass for the galaxy, twice as large as the stellar mass. The spatial and velocity distribution of the H I 21 cm emission reveals a disturbed rotating gas disc, which suggests that the galaxy has undergone a recent minor merger that disrupted its rotation. We find that the Wolf-Rayet region and the GRB are both located in the highest H I column density region of the galaxy. We speculate that the merger event has resulted in shock compression of the gas, triggering extreme star formation activity, and resulting in the formation of both the Wolf-Rayet region and the GRB. The high H I column density environment of the GRB is consistent with the high H I column densities seen in absorption in the host galaxies of high-redshift GRBs.

Spitzer Observations of GRB Hosts: A Legacy Approach

NASA Astrophysics Data System (ADS)

Perley, Daniel; Tanvir, Nial; Hjorth, Jens; Berger, Edo; Laskar, Tanmoy; Michalowski, Michal; Chary, Ranga-Ram; Fynbo, Johan; Levan, Andrew

2012-09-01

The host galaxies of long-duration GRBs are drawn from uniquely broad range of luminosities and redshifts. Thus they offer the possibility of studying the evolution of star-forming galaxies without the limitations of other luminosity-selected samples, which typically are increasingly biased towards the most massive systems at higher redshift. However, reaping the full benefits of this potential requires careful attention to the selection biases affecting host identification. To this end, we propose observations of a Legacy sample of 70 GRB host galaxies (an additional 70 have already been observed by Spitzer), in order to constrain the mass and luminosity function in GRB-selected galaxies at high redshift, including its dependence on redshift and on properties of the afterglow. Crucially, and unlike previous Spitzer surveys, this sample is carefully designed to be uniform and free of optical selection biases that have caused previous surveys to systematically under-represent the role of luminous, massive hosts. We also propose to extend to larger, more powerfully constraining samples the study of two science areas where Spitzer observations have recently shown spectacular success: the hosts of dust-obscured GRBs (which promise to further our understanding of the connection between GRBs and star-formation in the most luminous galaxies), and the evolution of the mass-metallicity relation at z>2 (for which GRB host observations provide particularly powerful constraints on high-z chemical evolution).

THE STELLAR AGES AND MASSES OF SHORT GAMMA-RAY BURST HOST GALAXIES: INVESTIGATING THE PROGENITOR DELAY TIME DISTRIBUTION AND THE ROLE OF MASS AND STAR FORMATION IN THE SHORT GAMMA-RAY BURST RATE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leibler, C. N.; Berger, E.

2010-12-10

We present multi-band optical and near-infrared observations of 19 short {gamma}-ray burst (GRB) host galaxies, aimed at measuring their stellar masses and population ages. The goals of this study are to evaluate whether short GRBs track the stellar mass distribution of galaxies, to investigate the progenitor delay time distribution, and to explore any connection between long and short GRB progenitors. Using single stellar population models we infer masses of log(M{sub *}/M{sub sun}) {approx} 8.8-11.6, with a median of (log(M{sub *}/M{sub sun})) {approx} 10.1, and population ages of {tau}{sub *} {approx} 0.03-4.4 Gyr with a median of ({tau}{sub *}) {approx} 0.3more » Gyr. We further infer maximal masses of log(M{sub *}/M{sub sun}) {approx} 9.7-11.9 by assuming stellar population ages equal to the age of the universe at each host's redshift. Comparing the distribution of stellar masses to the general galaxy mass function, we find that short GRBs track the cosmic stellar mass distribution only if the late-type hosts generally have maximal masses. However, there is an apparent dearth of early-type hosts compared to the equal contribution of early- and late-type galaxies to the cosmic stellar mass budget. Similarly, the short GRB rate per unit old stellar mass appears to be elevated in the late-type hosts. These results suggest that stellar mass may not be the sole parameter controlling the short GRB rate, and raise the possibility of a two-component model with both mass and star formation playing a role (reminiscent of the case for Type Ia supernovae). If short GRBs in late-type galaxies indeed track the star formation activity, the resulting typical delay time is {approx}0.2 Gyr, while those in early-type hosts have a typical delay of {approx}3 Gyr. Using the same stellar population models, we fit the broadband photometry for 22 long GRB host galaxies in a similar redshift range and find that they have significantly lower masses and younger population ages, with (log(M{sub *}/M{sub sun})) {approx} 9.1 and ({tau}{sub *}) {approx} 0.06 Gyr, respectively; their maximal masses are similarly lower, (log(M{sub *}/M{sub sun})) {approx} 9.6, and as expected do not track the galaxy mass function. Most importantly, the two GRB host populations remain distinct even if we consider only the star-forming hosts of short GRBs, supporting our previous findings (based on star formation rates and metallicities) that the progenitors of long and short GRBs in late-type galaxies are distinct. Given the much younger stellar populations of long GRB hosts (and hence of long GRB progenitors), and the substantial differences in host properties, we caution against the use of Type I and II designations for GRBs since this may erroneously imply that all GRBs which track star formation activity share the same massive star progenitors.« less

Gas inflow and outflow in an interacting high-redshift galaxy. The remarkable host environment of GRB 080810 at z = 3.35

NASA Astrophysics Data System (ADS)

Wiseman, P.; Perley, D. A.; Schady, P.; Prochaska, J. X.; de Ugarte Postigo, A.; Krühler, T.; Yates, R. M.; Greiner, J.

2017-11-01

We reveal multiple components of an interacting galaxy system at z ≈ 3.35 through a detailed analysis of the exquisite high-resolution Keck/HIRES spectrum of the afterglow of a gamma-ray burst (GRB). Through Voigt-profile fitting of absorption lines from the Lyman series, we constrain the neutral hydrogen column density to NH I ≤ 1018.35 cm-2 for the densest of four distinct systems at the host redshift of GRB 080810, which is among the lowest NH I ever observed in a GRB host, even though the line of sight passes within a projected 5 kpc of the galaxy centres. By detailed analysis of the corresponding metal absorption lines, we derive chemical, ionic, and kinematic properties of the individual absorbing systems, and thus build a picture of the host as a whole. Striking differences between the systems imply that the line of sight passes through several phases of gas: the star-forming regions of the GRB host; enriched material in the form of a galactic outflow; the hot and ionised halo of a second interacting galaxy falling towards the host at a line-of-sight velocity of 700 km s-1; and a cool metal-poor cloud that may represent one of the best candidates yet for the inflow of metal-poor gas from the intergalactic medium. The reduced spectrum is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/607/A107

A novel explosive process is required for the gamma-ray burst GRB 060614.

PubMed

Gal-Yam, A; Fox, D B; Price, P A; Ofek, E O; Davis, M R; Leonard, D C; Soderberg, A M; Schmidt, B P; Lewis, K M; Peterson, B A; Kulkarni, S R; Berger, E; Cenko, S B; Sari, R; Sharon, K; Frail, D; Moon, D-S; Brown, P J; Cucchiara, A; Harrison, F; Piran, T; Persson, S E; McCarthy, P J; Penprase, B E; Chevalier, R A; MacFadyen, A I

2006-12-21

Over the past decade, our physical understanding of gamma-ray bursts (GRBs) has progressed rapidly, thanks to the discovery and observation of their long-lived afterglow emission. Long-duration (> 2 s) GRBs are associated with the explosive deaths of massive stars ('collapsars', ref. 1), which produce accompanying supernovae; the short-duration (< or = 2 s) GRBs have a different origin, which has been argued to be the merger of two compact objects. Here we report optical observations of GRB 060614 (duration approximately 100 s, ref. 10) that rule out the presence of an associated supernova. This would seem to require a new explosive process: either a massive collapsar that powers a GRB without any associated supernova, or a new type of 'engine', as long-lived as the collapsar but without a massive star. We also show that the properties of the host galaxy (redshift z = 0.125) distinguish it from other long-duration GRB hosts and suggest that an entirely new type of GRB progenitor may be required.

Possible correlations between gamma-ray burst and its host galaxy offset

NASA Astrophysics Data System (ADS)

Wang, Fei-Fei; Zou, Yuan-Chuan; Liu, Yu; Liao, Bin; Moharana, Reetanjali

2018-06-01

We collected the information of 304 gamma-ray bursts (GRBs) from the literature, and analyzed the correlations among the host galaxy offsets (the distance from the site of the GRB to the center of its host galaxy), T90,i (the duration T90 in rest-frame), TR45,i (the duration TR45 in rest-frame), Eγ,iso (the isotropic equivalent energy), Lγ,iso (=Eγ,iso /T90,i, the isotropic equivalent luminosity) and Lpk (peak luminosity). We found that T90,i, TR45,i, Eγ,iso, Lpk have negative correlation with offset, which is consistent with origin of short GRBs (SGRBs) and long GRBs (LGRBs). On separate analysis, we found similar results for log ⁡Eγ,iso - log ⁡ (offset) and log ⁡Lpk - log ⁡ (offset) relations in case of SGRBs only, while no obvious relation for LGRBs. There is no correlations between offset and Lγ,iso. We also put the special GRB 170817A and GRB 060218A on the plots. The two GRBs both have low luminosity and small offset. In the log ⁡ (offset) - log ⁡T90,i plot, we found GRB 170817A locates in between the two regions of SGRBs and LGRBs and it is the outlier in the offset -Eγ,iso, offset -Lγ,iso and offset -Lpk plots. Together with GRB 060218A being an outlier in all plots, it indicates the speciality of GRBs 170817A and 060218A, and might imply more subgroups of the GRB samples.

CGM-GRB: A survey of the CircumGalactic Medium around GRB hosts

NASA Astrophysics Data System (ADS)

Gatkine, Pradip; Veilleux, Sylvain; Cucchiara, Antonino; Cenko, Bradley

2018-01-01

Recent space- and ground-based studies of the circumgalactic medium around galaxies have revealed the dynamic interplay between the galaxy ecosystem and surrounding CGM using bright background quasars. Here, we extend this investigation of the CGM to higher redshifts by using the bright afterglows of gamma-ray bursts as background sources. This provides a unique opportunity to probe the host galaxy ISM and its surrounding CGM together. We compiled a sample of 25 high-resolution (R > 8000) and high-quality (typical S/N ~ 20) rest-frame UV spectra of GRB afterglows with a redshift range (1.5 < z < 5.9) obtained using Keck-HIRES, VLT-UVES, and VLT-X-shooter spectrographs. We fit multi-component Voigt profiles to several absorption lines of both high-ionization (O VI, C IV, Si IV, etc) and low-ionization species (Si II, C II, Fe II, etc) to extract the column densities (N), Doppler parameters (b) and line-centroids. The preliminary results of our analysis on the kinematics and physical properties of the ISM and CGM of these GRB hosts are presented here.

No supernovae detected in two long-duration gamma-ray bursts.

PubMed

Watson, D; Fynbo, J P U; Thöne, C C; Sollerman, J

2007-05-15

There is strong evidence that long-duration gamma-ray bursts (GRBs) are produced during the collapse of a massive star. In the standard version of the collapsar model, a broad-lined and luminous Type Ic core-collapse supernova (SN) accompanies the GRB. This association has been confirmed in observations of several nearby GRBs. Recent observations show that some long-duration GRBs are different. No SN emission accompanied the long-duration GRBs 060505 and 060614 down to limits fainter than any known Type Ic SN and hundreds of times fainter than the archetypal SN 1998bw that accompanied GRB 980425. Multi-band observations of the early afterglows, as well as spectroscopy of the host galaxies, exclude the possibility of significant dust obscuration. Furthermore, the bursts originated in star-forming galaxies, and in the case of GRB 060505, the burst was localized to a compact star-forming knot in a spiral arm of its host galaxy. We find that the properties of the host galaxies, the long duration of the bursts and, in the case of GRB 060505, the location of the burst within its host, all imply a massive stellar origin. The absence of an SN to such deep limits therefore suggests a new phenomenological type of massive stellar death.

Identifying the Location in the Host Galaxy of Short GRB 1111l7A with the Chandra Sub- Arcsecond Position

NASA Technical Reports Server (NTRS)

Sakamoto, Takanori; Troja, E.; Aoki, K.; Guiriec, S.; Im, M.; Leloudas, G.; Malesani, D.; Melandri, A.; deUgartePostigo, A.; Urata, Y.;

In Search of Progenitors for Supernovaless Gamma-Ray Bursts 060505 and 060614: Re-examination of Their Afterglows

NASA Astrophysics Data System (ADS)

Xu, D.; Starling, R. L. C.; Fynbo, J. P. U.; Sollerman, J.; Yost, S.; Watson, D.; Foley, S.; O'Brien, P. T.; Hjorth, J.

2009-05-01

GRB 060505 and GRB 060614 are nearby long-duration gamma-ray bursts (LGRBs) without accompanying supernovae (SNe) down to very strict limits. They thereby challenge the conventional LGRB-SN connection and naturally give rise to the question: are there other peculiar features in their afterglows which would help shed light on their progenitors? To answer this question, we combine new observational data with published data and investigate the multiband temporal and spectral properties of the two afterglows. We find that both afterglows can be well interpreted within the framework of the jetted standard external shock wave model, and that the afterglow parameters for both bursts fall well within the range observed for other LGRBs. Hence, from the properties of the afterglows there is nothing to suggest that these bursts should have another progenitor than other LGRBs. Recently, Swift-discovered GRB 080503 also has the spike + tail structure during its prompt γ-ray emission seemingly similar to GRB 060614. We analyze the prompt emission of this burst and find that this GRB is actually a hard-spike + hard-tail burst with a spectral lag of 0.8 ± 0.4 s during its tail emission. Thus, the properties of the prompt emission of GRB 060614 and GRB 080503 are clearly different, motivating further thinking of GRB classification (and even identification of faint core-collapse SNe). Finally, we note that, whereas the progenitor of the two SN-less bursts remains uncertain, the core-collapse origin for the SN-less bursts would be quite certain if a windlike environment can be observationally established, e.g., from an optical decay faster than the X-ray decay in the afterglow's slow cooling phase. Based on observations collected at the European Organization for Astronomical Research in the Southern Hemisphere, Chile, under programs 077.D-0661 and 177.A-0591.

Gamma-Ray Bursts in the Swift Era

NASA Technical Reports Server (NTRS)

Gehrels, Neil; Cannizzo, John K.; Norris, Jay P.

2007-01-01

GRB research has undergone a revolution in the last two years. The launch of Swift, with its rapid slewing capability, has greatly increased the number and quality of GRB localizations and X-ray and optical afterglow lightcurves. Over 160 GRBs have been detected, and nearly all that have been followed up with the on-board narrow field telescopes. Advances in our understanding of short GRBs have been spectacular. The detection of X-ray afterglows has led to accurate localizations from ground based observatories, which have given host identifications and redshifts. Theoretical models for short GRB progenitors have, for the first time, been placed on a sound foundation. The hosts for the short GRBs differ in a fundamental way from the long GRB hosts: short GRBs tend to occur in non-star forming galaxies or regions, whereas long GRBs are strongly concentrated within star forming regions. Observations are consistent with a binary neutron star merger model, but other models involving old stellar populations are also viable. Swift has greatly increased the redshift range of GRB detection. The highest redshift GRBs, at zeta approx. 5-6, are approaching the era of reionization. Ground-based deep optical spectroscopy of high redshift bursts is giving metallicity measurements and other information on the source environment to much greater distance than other techniques. The localization of GRB 060218 to a nearby galaxy, and association with SN 2006aj, added a valuable member to the class of GRBs with detected supernova. The prospects for future progress are excellent given the >10 year orbital lifetime of the Swift satellite.

A search for non-triggered events in the BATSE data base

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kommers, J. M.; Lewin, W. H. G.; Kouveliotou, C.

1998-05-16

The archival data from BATSE permit a search for transients that did not activate the onboard burst trigger. Examples of such non-triggered events include faint gamma-ray bursts (GRBs), emission from soft gamma-ray repeaters (SGRs), and bursts and flares from X-ray binaries. A GRB may fail to trigger onboard because it is too faint, because it occurs while the onboard trigger is disabled, or because it biases the onboard background estimation. We describe a search of the BATSE archival data that is sensitive to GRBs with peak fluxes fainter by a factor of {approx}2 than those detected with the onboard burstmore » trigger (on the 1.024 s time scale)« less

The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. VIII. A Comparison to Cosmological Short-duration Gamma-Ray Bursts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fong, W.; Berger, E.; Blanchard, P. K.

Here, we present a comprehensive comparison of the properties of the radio through X-ray counterpart of GW170817 and the properties of short-duration gamma-ray bursts (GRBs). For this effort, we utilize a sample of 36 short GRBs spanning a redshift range ofmore » $$z \\approx 0.12-2.6$$ discovered over 2004-2017. We find that the counterpart to GW170817 has an isotropic-equivalent luminosity that is $$\\approx 3000$$ times less than the median value of on-axis short GRB X-ray afterglows, and $$\\gtrsim10^{4}$$ times less than that for detected short GRB radio afterglows. Moreover, the allowed jet energies and particle densities inferred from the radio and X-ray counterparts to GW170817 and on-axis short GRB afterglows are remarkably similar, suggesting that viewing angle effects are the dominant, and perhaps only, difference in their observed radio and X-ray behavior. From comparison to previous claimed kilonovae following short GRBs, we find that the optical and near-IR counterpart to GW170817 is comparatively under-luminous by a factor of $$\\approx 3-5$$, indicating a range of kilonova luminosities and timescales. A comparison of the optical limits following short GRBs on $$\\lesssim 1$$ day timescales also rules out a "blue" kilonova of comparable optical isotropic-equivalent luminosity in one previous short GRB. Finally, we investigate the host galaxy of GW170817, NGC4993, in the context of short GRB host galaxy stellar population properties. We find that NGC4993 is superlative in terms of its large luminosity, old stellar population age, and low star formation rate compared to previous short GRB hosts. Additional events within the Advanced LIGO/VIRGO volume will be crucial in delineating the properties of the host galaxies of NS-NS mergers, and connecting them to their cosmological counterparts.« less

The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. VIII. A Comparison to Cosmological Short-duration Gamma-Ray Bursts

DOE PAGES

Fong, W.; Berger, E.; Blanchard, P. K.; ...

2017-10-16

Here, we present a comprehensive comparison of the properties of the radio through X-ray counterpart of GW170817 and the properties of short-duration gamma-ray bursts (GRBs). For this effort, we utilize a sample of 36 short GRBs spanning a redshift range ofmore » $$z \\approx 0.12-2.6$$ discovered over 2004-2017. We find that the counterpart to GW170817 has an isotropic-equivalent luminosity that is $$\\approx 3000$$ times less than the median value of on-axis short GRB X-ray afterglows, and $$\\gtrsim10^{4}$$ times less than that for detected short GRB radio afterglows. Moreover, the allowed jet energies and particle densities inferred from the radio and X-ray counterparts to GW170817 and on-axis short GRB afterglows are remarkably similar, suggesting that viewing angle effects are the dominant, and perhaps only, difference in their observed radio and X-ray behavior. From comparison to previous claimed kilonovae following short GRBs, we find that the optical and near-IR counterpart to GW170817 is comparatively under-luminous by a factor of $$\\approx 3-5$$, indicating a range of kilonova luminosities and timescales. A comparison of the optical limits following short GRBs on $$\\lesssim 1$$ day timescales also rules out a "blue" kilonova of comparable optical isotropic-equivalent luminosity in one previous short GRB. Finally, we investigate the host galaxy of GW170817, NGC4993, in the context of short GRB host galaxy stellar population properties. We find that NGC4993 is superlative in terms of its large luminosity, old stellar population age, and low star formation rate compared to previous short GRB hosts. Additional events within the Advanced LIGO/VIRGO volume will be crucial in delineating the properties of the host galaxies of NS-NS mergers, and connecting them to their cosmological counterparts.« less

A peculiar low-luminosity short gamma-ray burst from a double neutron star merger progenitor.

PubMed

Zhang, B-B; Zhang, B; Sun, H; Lei, W-H; Gao, H; Li, Y; Shao, L; Zhao, Y; Hu, Y-D; Lü, H-J; Wu, X-F; Fan, X-L; Wang, G; Castro-Tirado, A J; Zhang, S; Yu, B-Y; Cao, Y-Y; Liang, E-W

2018-01-31

Double neutron star (DNS) merger events are promising candidates of short gamma-ray burst (sGRB) progenitors as well as high-frequency gravitational wave (GW) emitters. On August 17, 2017, such a coinciding event was detected by both the LIGO-Virgo gravitational wave detector network as GW170817 and Gamma-Ray Monitor on board NASA's Fermi Space Telescope as GRB 170817A. Here, we show that the fluence and spectral peak energy of this sGRB fall into the lower portion of the distributions of known sGRBs. Its peak isotropic luminosity is abnormally low. The estimated event rate density above this luminosity is at least [Formula: see text] Gpc -3  yr -1 , which is close to but still below the DNS merger event rate density. This event likely originates from a structured jet viewed from a large viewing angle. There are similar faint soft GRBs in the Fermi archival data, a small fraction of which might belong to this new population of nearby, low-luminosity sGRBs.

GRB 050717: A Long, Short-Lag Burst Observed by Swift and Konus

NASA Technical Reports Server (NTRS)

Krimm, H. A.; Hurkett, C.; Pal'shin, V.; Norris, J. P.; Zhang, B.; Barthelmy, S. D.; Burrows, D. N.; Gehrels, N.; Golenetskii, S.; Osborne, J. P.;

DEMOGRAPHICS OF THE GALAXIES HOSTING SHORT-DURATION GAMMA-RAY BURSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fong, W.; Berger, E.; Chornock, R.

We present observations of the afterglows and host galaxies of three short-duration gamma-ray bursts (GRBs): 100625A, 101219A, and 110112A. We find that GRB 100625A occurred in a z = 0.452 early-type galaxy with a stellar mass of Almost-Equal-To 4.6 Multiplication-Sign 10{sup 9} M{sub Sun} and a stellar population age of Almost-Equal-To 0.7 Gyr, and GRB 101219A originated in a star-forming galaxy at z = 0.718 with a stellar mass of Almost-Equal-To 1.4 Multiplication-Sign 10{sup 9} M{sub Sun }, a star formation rate of Almost-Equal-To 16 M{sub Sun} yr{sup -1}, and a stellar population age of Almost-Equal-To 50 Myr. We alsomore » report the discovery of the optical afterglow of GRB 110112A, which lacks a coincident host galaxy to i {approx}> 26 mag, and we cannot conclusively identify any field galaxy as a possible host. From afterglow modeling, the bursts have inferred circumburst densities of Almost-Equal-To 10{sup -4}-1 cm{sup -3} and isotropic-equivalent gamma-ray and kinetic energies of Almost-Equal-To 10{sup 50}-10{sup 51} erg. These three events highlight the diversity of galactic environments that host short GRBs. To quantify this diversity, we use the sample of 36 Swift short GRBs with robust associations to an environment ({approx}1/2 of 68 short bursts detected by Swift to 2012 May) and classify bursts originating from four types of environments: late-type ( Almost-Equal-To 50%), early-type ( Almost-Equal-To 15%), inconclusive ( Almost-Equal-To 20%), and ''host-less'' (lacking a coincident host galaxy to limits of {approx}> 26 mag; Almost-Equal-To 15%). To find likely ranges for the true late- and early-type fractions, we assign each of the host-less bursts to either the late- or early-type category using probabilistic arguments and consider the scenario that all hosts in the inconclusive category are early-type galaxies to set an upper bound on the early-type fraction. We calculate most likely ranges for the late- and early-type fractions of Almost-Equal-To 60%-80% and Almost-Equal-To 20%-40%, respectively. We find no clear trend between gamma-ray duration and host type. We also find no change to the fractions when excluding events recently claimed as possible contaminants from the long GRB/collapsar population. Our reported demographics are consistent with a short GRB rate driven by both stellar mass and star formation.« less

Gamma-ray bursts and their use as cosmic probes

PubMed Central

2017-01-01

Since the launch of the highly successful and ongoing Swift mission, the field of gamma-ray bursts (GRBs) has undergone a revolution. The arcsecond GRB localizations available within just a few minutes of the GRB alert has signified the continual sampling of the GRB evolution through the prompt to afterglow phases revealing unexpected flaring and plateau phases, the first detection of a kilonova coincident with a short GRB, and the identification of samples of low-luminosity, ultra-long and highly dust-extinguished GRBs. The increased numbers of GRB afterglows, GRB-supernova detections, redshifts and host galaxy associations has greatly improved our understanding of what produces and powers these immense, cosmological explosions. Nevertheless, more high-quality data often also reveal greater complexity. In this review, I summarize some of the milestones made in GRB research during the Swift era, and how previous widely accepted theoretical models have had to adapt to accommodate the new wealth of observational data. PMID:28791158

Very Large Telescope/Ultraviolet and Visual Echelle Spectrograph and FORS2 spectroscopy of the GRB 081008 afterglow

NASA Astrophysics Data System (ADS)

D'Elia, V.; Campana, S.; Covino, S.; D'Avanzo, P.; Piranomonte, S.; Tagliaferri, G.

2011-11-01

We aim at studying the gamma-ray burst (GRB), GRB 081008, environment by analysing the spectra of its optical afterglow. Ultraviolet and Visual Echelle Spectrograph/Very Large Telescope (UVES/VLT) high-resolution spectroscopy of GRB 081008 was secured ˜5 h after the Swift-BAT trigger. Our data set also comprises three VLT/FORS2 nearly simultaneous spectra of the same source. The availability of nearly simultaneous high- and low-resolution spectra for a GRB afterglow is an extremely rare event. The GRB-damped Lyman α system at z= 1.9683 shows that the interstellar medium (ISM) of the host galaxy is constituted by at least three components which contribute to the line profiles. Component I is the redmost one, and is 20 and 78 km s-1 redward components II and III, respectively. We detect several ground state and excited absorption features in components I and II. These features have been used to compute the distances between the GRB and the absorbers. Component I is found to be 52 ± 6 pc away from the GRB, while component II presents few excited transitions and its distance is 200+60- 80 pc. Component III only features a few, low-ionization and saturated lines suggesting that it is even farther from the GRB. Component I represents the closest absorber ever detected near a GRB. This (relatively) low distance can possibly be a consequence of a dense GRB environment, which prevents the GRB prompt/afterglow emission to strongly affect the ISM up to higher distances. The hydrogen column density associated with GRB 081008 is log NH/cm-2= 21.11 ± 0.10, and the metallicity of the host galaxy is in the range of [X/H] =-1.29 to -0.52. In particular, we found [Fe/H] =-1.19 ± 0.11 and [Zn/H] =-0.52 ± 0.11 with respect to solar values. This discrepancy can be explained by the presence of dust in the GRB ISM, given the opposite refractory properties of iron and zinc. By deriving the depletion pattern for GRB 081008, we find the optical extinction in the visual band to be AV˜ 0.19 mag. The curve-of-growth analysis applied to the FORS2 spectra brings column densities consistent at the 3σ level to that evaluated from the UVES data using the line-fitting procedure. This reflects the low saturation of the detected GRB 081008 absorption features. Based on observations collected at the European Southern Observatory, ESO, the VLT/Kueyen telescope, Paranal, Chile, in the framework of the programme 082-0755.

Exploring the Cosmic Dawn, Galaxy Evolution, and Exotic Stellar Deaths with Rapid GRB Follow-Up Observations

NASA Astrophysics Data System (ADS)

Berger, Edo; Cenko, Stephen; Schmidt, Brian; Perley, Daniel; Berger, Edo; Fox, Derek; Fruchter, Andrew; Bloom, Joshua; Prochaska, Jason X.; Lopez, Sebastian; Cobb, Bethany; Roth, Kathy; Levan, Andrew; Tanvir, Nial; Rapoport, Sharon; Yuan, Fang; Chornock, Ryan; Wen-Fai, Fong; Morgan, Adam; Wiersema, Klaas; Cucchiara, Antonino

2013-08-01

The study of gamma-ray burst (GRB) afterglows, host galaxies, and associated supernovae (SNe) sheds light on a wide range of open questions in astrophysics, ranging from the deaths of massive stars to cosmic chemical enrichment and the reionization epoch, and soon, the electromagnetic (EM) counterparts of gravitational wave (GW) sources. Over the past decade, Gemini has played a leading role in all aspects of GRB science through its combination of rapid-response spectroscopy and imaging coupled with deep late-time host galaxy, afterglow, and GRB-SN follow-up. Here, we propose to step forward in our long-standing program of ToO observations, with this proposal focusing on "Rapid ToO" science, observations at t <˜ 1 day. In conjunction with an array of multi-wavelength EM facilities, we focus on three key science topics: (1) Identification, characterization, and exploitation of high-redshift GRBs in order to study the evolving IGM and galaxy populations at these redshifts; (2) Studies of short GRB afterglows and their environments to yield insight into the nature of their progenitor population, for connection with forthcoming GW facilities; and (3) Observation of exceptionally energetic bursts detected by the Fermi-LAT instrument, to test models of burst engines and enable their use as testbeds for quantum gravity effects.

Exploring the Cosmic Dawn, Galaxy Evolution, and Exotic Stellar Deaths with Rapid GRB Follow-Up Observations

NASA Astrophysics Data System (ADS)

Berger, Edo; Fox, Derek; Chornock, Ryan; Fong, Wen-Fai; Cobb, Bethany; Cenko, Brad; Perley, Daniel; Bloom, Joshua; Prochaska, Jason X.; Morgan, Adam; Cucchiara, Antonino; Levan, Andrew; Tanvir, Nial; Fruchter, Andrew; Lopez, Sebastian; Wiersema, Klaas; Roth, Kathy

2014-02-01

The study of gamma-ray burst (GRB) afterglows, host galaxies, and associated supernovae (SNe) sheds light on a wide range of open questions in astrophysics, ranging from the deaths of massive stars to cosmic chemical enrichment and the reionization epoch, and soon, the electromagnetic (EM) counterparts of gravitational wave (GW) sources. Over the past decade, Gemini has played a leading role in all aspects of GRB science through its combination of rapid-response spectroscopy and imaging coupled with deep late-time host galaxy, afterglow, and GRB-SN follow-up. Here, we propose to step forward in our long-standing program of ToO observations, with this proposal focusing on "Rapid ToO" science, observations at t <˜ 1 day. In conjunction with an array of multi-wavelength EM facilities, we focus on three key science topics: (1) Identification, characterization, and exploitation of high-redshift GRBs in order to study the evolving IGM and galaxy populations at these redshifts; (2) Studies of short GRB afterglows and their environments to yield insight into the nature of their progenitor population, for connection with forthcoming GW facilities; and (3) Observation of exceptionally energetic bursts detected by the Fermi-LAT instrument, to test models of burst engines and enable their use as testbeds for quantum gravity effects.

Probing Cosmic Star Formation Using Long Gamma-Ray Bursts: New Constraints from the Spitzer Space Telescope

NASA Astrophysics Data System (ADS)

Le Floc'h, Emeric; Charmandaris, Vassilis; Forrest, William J.; Mirabel, I. Félix; Armus, Lee; Devost, Daniel

2006-05-01

We report on IRAC 4.5 μm, IRAC 8.0 μm, and MIPS 24 μm deep observations of 16 gamma-ray burst (GRB) host galaxies performed with the Spitzer Space Telescope, and we investigate in the thermal infrared the presence of evolved stellar populations and dust-enshrouded star-forming activity associated with these objects. Our sample is derived from GRBs that were identified with subarcsecond localization between 1997 and 2001, and only a very small fraction (~20%) of the targeted sources are detected down to f4.5μm~3.5 μJy and f24μm~85 μJy (3 σ). This likely argues against a population dominated by massive and strongly starbursting (i.e., SFR>~100 Msolar yr-1) galaxies as has been recently suggested from submillimeter/radio and optical studies of similarly selected GRB hosts. Furthermore, we find evidence that some GRBs do not occur in the most infrared luminous regions-hence the most actively star-forming environments-of their host galaxies. Should the GRB hosts be representative of all star-forming galaxies at high redshift, models of infrared galaxy evolution indicate that >~50% of GRB hosts should have f24μm>~100 μJy. Unless the identification of GRBs prior to 2001 was prone to strong selection effects biasing our sample against dusty galaxies, we infer in this context that the GRBs identified with the current techniques cannot be directly used as unbiased probes of the global and integrated star formation history of the universe. Based on observations made with the Spitzer Space Telescope, operated by the Jet Propulsion Laboratory under NASA contract 1407.

SWIFT Detects a remarkable Gamma-ray Burst, GRB 060514, that introduces a New Classification Scheme

NASA Technical Reports Server (NTRS)

Gehrels, N.; Norris, J. P.; Mangano, V.; Barthelmy, S. D.; Burrows, D. N.; Granot, J.; Kaneko, Y.; Kouveliotou, C.; Markwardt, C. B.; Meszaros, P.;

Hubble Space Telescope Observations of the Afterglow, Supernova and Host Galaxy Associated with the Extremely Bright GRB 130427A

NASA Technical Reports Server (NTRS)

Levan, A.J.; Tanvir, N. R.; Fruchter, A. S.; Hjorth, J.; Pian, E.; Mazzali, P.; Hounsell, R. A.; Perley, D. A.; Cano, Z.; Graham, J.;

DISCOVERY OF SN 2009nz ASSOCIATED WITH GRB 091127

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cobb, B. E.; Bloom, J. S.; Perley, D. A.

2010-08-01

We report SMARTS, Gemini, and Swift-UVOT observations of the optical transient (OT) associated with gamma-ray burst (GRB) 091127, at redshift 0.49, taken between 0.9 hr and 102 days following the Swift trigger. In our early-time observations, the OT fades in a manner consistent with previously observed GRB afterglows. However, after nine days post-burst, the OT is observed to brighten for a period of {approx}two weeks, after which the source resumes fading. A comparison of this late-time 'bump' to SN 1998bw (the broad-lined Type Ic supernova associated with GRB 980425), and several other GRB supernovae (SNe), indicates that the most straightforwardmore » explanation is that GRB 091127 was accompanied by a contemporaneous SN (SN 2009nz) that peaked at a magnitude of M{sub V} = -19.0 {+-} 0.2. SN 2009nz is globally similar to other GRB SNe, but evolves slightly faster than SN 1998bw and reaches a slightly dimmer peak magnitude. We also analyze the early-time UV-optical-IR spectral energy distribution of the afterglow of GRB 091127 and find that there is little to no reddening in the host galaxy along the line of sight to this burst.« less

GRB070125: The First Long-Duration Gamma-Ray Burst in a Halo Environment

NASA Technical Reports Server (NTRS)

Bradley, Cenko S.; Fox, Derek B.; Penprase, Brian E.; Kulkarni, Shri R.; Price, Paul A.; Berger, Edo; Kulkarni, Shri R.; Harrison, Fiona A.; Gal-Yam, Avishay; Ofek, Eran O.;

The Diverse Environments of Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Perley, Daniel Alan

I present results from several years of concerted observations of the afterglows and host galaxies of gamma-ray bursts (GRBs), the most energetic explosions in the Universe. Short gamma-ray bursts originate from a wide variety of environments, including disk galaxies, elliptical galaxies, galaxy haloes, and intracluster and intergalactic space. Long gamma ray bursts associate almost exclusively with star-forming hosts, but the properties of these galaxies also vary widely. Some are hosted in extremely small galaxies, difficult to identify directly in emission or infer from the absorption of afterglow light, but the host luminosity distribution extends up to very luminous (> L*) systems as well. A significant fraction of long GRBs are observed along highly dust-obscured sightlines through their host medium. Some of these events are hosted within conspicuously dusty galaxies, although the hosts of other dust-obscured events show no outward signs of significant internal dust content. By measuring the wavelength dependence of dust absorption profiles using a few well-observed GRB afterglows, I provide evidence for ordinary dust with properties similar to those of dust in the Milky Way in a system at z ˜ 3, but a very different absorption profile from the dust in a galaxy at z ˜ 5, providing tentative evidence to support a transition in dust composition early in the history of the Universe. I present an observationally-determined redshift distribution for Swift GRBs, showing few to originate from high redshifts (z ≳ 5). I also provide the first photometric and spectroscopic catalogs from one of the largest GRB host-galaxy surveys ever conducted, including observations of almost 150 distinct GRB fields.

ALMA observations of the host galaxy of GRB 090423 at z = 8.23: deep limits on obscured star formation 630 million years after the big bang

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berger, E.; Zauderer, B. A.; Chary, R.-R.

2014-12-01

We present rest-frame far-infrared (FIR) and optical observations of the host galaxy of GRB 090423 at z = 8.23 from the Atacama Large Millimeter Array (ALMA) and the Spitzer Space Telescope, respectively. The host remains undetected to 3σ limits of F {sub ν}(222 GHz) ≲ 33 μJy and F {sub ν}(3.6 μm) ≲ 81 nJy. The FIR limit is about 20 times fainter than the luminosity of the local ULIRG Arp 220 and comparable to the local starburst M 82. Comparing this with model spectral energy distributions, we place a limit on the infrared (IR) luminosity of L {sub IR}(8-1000more » μm) ≲ 3 × 10{sup 10} L {sub ☉}, corresponding to a limit on the obscured star formation rate of SFR{sub IR}≲5 M {sub ☉} yr{sup –1}. For comparison, the limit on the unobscured star formation rate from Hubble Space Telescope rest-frame ultraviolet (UV) observations is SFR{sub UV} ≲ 1 M {sub ☉} yr{sup –1}. We also place a limit on the host galaxy stellar mass of M {sub *} ≲ 5 × 10{sup 7} M {sub ☉} (for a stellar population age of 100 Myr and constant star formation rate). Finally, we compare our millimeter observations to those of field galaxies at z ≳ 4 (Lyman break galaxies, Lyα emitters, and submillimeter galaxies) and find that our limit on the FIR luminosity is the most constraining to date, although the field galaxies have much larger rest-frame UV/optical luminosities than the host of GRB 090423 by virtue of their selection techniques. We conclude that GRB host galaxies at z ≳ 4, especially those with measured interstellar medium metallicities from afterglow spectroscopy, are an attractive sample for future ALMA studies of high redshift obscured star formation.« less

A targeted LIGO-Virgo search for gravitational waves associated with gamma-ray bursts using low-threshold swift GRB triggers

NASA Astrophysics Data System (ADS)

Harstad, Emelie D.

Gamma-ray bursts (GRBs) are short, intense ashes of 0.1-1 MeV electromagnetic radiation that are routinely observed by Earth orbiting satellites. The sources of GRBs are known to be extragalactic and located at cosmological distances. Due to the extremely high isotropic equivalent energies of GRBs, which are on the order of Eiso˜1054 erg, the gamma-ray emission is believed to be collimated, making them observable only when they are directed towards Earth. The favored progenitor models of GRBs are also believed to emit gravitational waves that would be observable by the current generation of ground-based interferometric gravitational wave detectors. The LIGO (Laser Interferometer Gravitational-Wave Observatory) and Virgo instruments operated near design sensitivity and collected more than a year of triple coincident data during the S5/VSR1 science run, which spanned the two year interval between November 2005 and October 2007. During this time, GRB detections were being made by the NASA/Goddard Swift Burst Alert Telescope at a rate of approximately 0.3 per day, producing a collection of triggers that has since been used in a coincident GRB-GW burst search with data from the LIGO-Virgo interferometer network. This dissertation describes the search for gravitational waves using the times and locations of 123 below-threshold potential GRB triggers from Swift over the same time period. Although most of the below-threshold triggers are likely false alarms, there is reason to believe that some are the result of actual faintly-observed GRB events. Recent GRB observations indicate that the local rate of low-luminosity GRBs is much higher than previously believed. This result, combined with the possibility of discovering a rare nearby GRB event accompanied by gravitational waves, is what motivates this search. The analysis results indicate no evidence for gravitational waves associated with any of the below-threshold triggers. A median distance lower limit of ˜16 Mpc was derived for a typical neutron star-black hole coalescence progenitor assumption.

A new gamma-ray burst classification scheme from GRB 060614.

PubMed

Gehrels, N; Norris, J P; Barthelmy, S D; Granot, J; Kaneko, Y; Kouveliotou, C; Markwardt, C B; Mészáros, P; Nakar, E; Nousek, J A; O'Brien, P T; Page, M; Palmer, D M; Parsons, A M; Roming, P W A; Sakamoto, T; Sarazin, C L; Schady, P; Stamatikos, M; Woosley, S E

2006-12-21

Gamma-ray bursts (GRBs) are known to come in two duration classes, separated at approximately 2 s. Long-duration bursts originate from star-forming regions in galaxies, have accompanying supernovae when these are near enough to observe and are probably caused by massive-star collapsars. Recent observations show that short-duration bursts originate in regions within their host galaxies that have lower star-formation rates, consistent with binary neutron star or neutron star-black hole mergers. Moreover, although their hosts are predominantly nearby galaxies, no supernovae have been so far associated with short-duration GRBs. Here we report that the bright, nearby GRB 060614 does not fit into either class. Its approximately 102-s duration groups it with long-duration GRBs, while its temporal lag and peak luminosity fall entirely within the short-duration GRB subclass. Moreover, very deep optical observations exclude an accompanying supernova, similar to short-duration GRBs. This combination of a long-duration event without an accompanying supernova poses a challenge to both the collapsar and the merging-neutron-star interpretations and opens the door to a new GRB classification scheme that straddles both long- and short-duration bursts.

SN 2010ay is a Luminous and Broad-lined Type Ic Supernova within a Low-metallicity Host Galaxy

NASA Technical Reports Server (NTRS)

Sanders, N. E.; Soderberg, A. M.; Valenti, S.; Chomiuk, L.; Berger, E.; Smartt, S.; Hurley, K.; Barthelmy, S. D.; Chornock, R.; Foley, R. J.;

Observations of Gamma-Ray Bursts by HETE-2

NASA Technical Reports Server (NTRS)

Kawai, N.; Matsuoka, M.; Yoshida, A.; Shirasaki, Y.; Ricker, G.; Doty, J.; Vanderspek, R.; Crew, G.; Villasenor, J.; Atteia, J.-L.;

Identifying High-redshift Gamma-Ray Bursts with RATIR

NASA Astrophysics Data System (ADS)

Littlejohns, O. M.; Butler, N. R.; Cucchiara, A.; Watson, A. M.; Kutyrev, A. S.; Lee, W. H.; Richer, M. G.; Klein, C. R.; Fox, O. D.; Prochaska, J. X.; Bloom, J. S.; Troja, E.; Ramirez-Ruiz, E.; de Diego, J. A.; Georgiev, L.; González, J.; Román-Zúñiga, C. G.; Gehrels, N.; Moseley, H.

2014-07-01

We present a template-fitting algorithm for determining photometric redshifts, z phot, of candidate high-redshift gamma-ray bursts (GRBs). Using afterglow photometry, obtained by the Reionization and Transients InfraRed (RATIR) camera, this algorithm accounts for the intrinsic GRB afterglow spectral energy distribution, host dust extinction, and the effect of neutral hydrogen (local and cosmological) along the line of sight. We present the results obtained by this algorithm and the RATIR photometry of GRB 130606A, finding a range of best-fit solutions, 5.6 < z phot < 6.0, for models of several host dust extinction laws (none, the Milky Way, Large Magellanic Clouds, and Small Magellanic Clouds), consistent with spectroscopic measurements of the redshift of this GRB. Using simulated RATIR photometry, we find that our algorithm provides precise measures of z phot in the ranges of 4 < z phot <~ 8 and 9 < z phot < 10 and can robustly determine when z phot > 4. Further testing highlights the required caution in cases of highly dust-extincted host galaxies. These tests also show that our algorithm does not erroneously find z phot < 4 when z sim > 4, thereby minimizing false negatives and allowing us to rapidly identify all potential high-redshift events.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, D.; French, J.; Hjorth, J.

Gamma-ray burst (GRB) host galaxies have been studied extensively in optical photometry and spectroscopy. Here we present the first mid-infrared spectrum of a GRB host, HG 031203. It is one of the nearest GRB hosts at z = 0.1055, allowing both low- and high-resolution spectroscopy with the Spitzer Infrared Spectrograph (IRS). Medium-resolution UV to K-band spectroscopy with the X-shooter spectrograph on the Very Large Telescope is also presented, along with Spitzer IRAC and MIPS photometry, as well as radio and submillimeter observations. These data allow us to construct a UV to radio spectral energy distribution with almost complete spectroscopic coveragemore » from 0.3 to 35 {mu}m of a GRB host galaxy for the first time, potentially valuable as a template for future model comparisons. The IRS spectra show strong, high-ionization fine structure line emission indicative of a hard radiation field in the galaxy-in particular the [S IV]/[S III] and [Ne III]/[Ne II] ratios-suggestive of strong ongoing star formation and a very young stellar population. The absence of any polycyclic aromatic hydrocarbon emission supports these conclusions, as does the probable hot peak dust temperature, making HG 031203 similar to the prototypical blue compact dwarf galaxy (BCD), II Zw 40. The selection of HG 031203 via the presence of a GRB suggests that it might be a useful analog of very young star-forming galaxies in the early universe, and hints that local BCDs may be used as more reliable analogs of star formation in the early universe than typical local starbursts. We look at the current debate on the ages of the dominant stellar populations in z {approx} 7 and z {approx} 8 galaxies in this context. The nebular line emission is so strong in HG 031203 that at z {approx} 7, it can reproduce the spectral energy distributions of z-band dropout galaxies with elevated IRAC 3.6 and 4.5 {mu}m fluxes without the need to invoke a 4000 A break. Indeed, photometry of HG 031203 shows elevation of the broadband V-magnitude at a level similar to the IRAC elevation in stacked z-band dropouts, solely due to its strong [O III] line emission.« less

GRB 080517: a local, low-luminosity gamma-ray burst in a dusty galaxy at z = 0.09

NASA Astrophysics Data System (ADS)

Stanway, Elizabeth R.; Levan, Andrew J.; Tanvir, Nial; Wiersema, Klaas; van der Horst, Alexander; Mundell, Carole G.; Guidorzi, Cristiano

2015-02-01

We present an analysis of the photometry and spectroscopy of the host galaxy of Swift-detected GRB 080517. From our optical spectroscopy, we identify a redshift of z = 0.089 ± 0.003, based on strong emission lines, making this a rare example of a very local, low-luminosity, long gamma-ray burst. The galaxy is detected in the radio with a flux density of S4.5 GHz = 0.22 ± 0.04 mJy - one of relatively few known gamma-ray bursts hosts with a securely measured radio flux. Both optical emission lines and a strong detection at 22 μm suggest that the host galaxy is forming stars rapidly, with an inferred star formation rate ˜16 M⊙ yr-1 and a high dust obscuration (E(B - V) > 1, based on sightlines to the nebular emission regions). The presence of a companion galaxy within a projected distance of 25 kpc, and almost identical in redshift, suggests that star formation may have been triggered by galaxy-galaxy interaction. However, fitting of the remarkably flat spectral energy distribution from the ultraviolet through to the infrared suggests that an older, 500 Myr post-starburst stellar population is present along with the ongoing star formation. We conclude that the host galaxy of GRB 080517 is a valuable addition to the still very small sample of well-studied local gamma-ray burst hosts.

The Swift Gamma-Ray Burst Host Galaxy Legacy Survey. I. Sample Selection and Redshift Distribution

NASA Technical Reports Server (NTRS)

Perley, D. A.; Kruhler, T.; Schulze, S.; Postigo, A. De Ugarte; Hjorth, J.; Berger, E.; Cenko, S. B.; Chary, R.; Cucchiara, A.; Ellis, R.;

HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction

PubMed Central

Rom, Slava; Pacifici, Marco; Passiatore, Giovanni; Aprea, Susanna; Waligorska, Agnieszka; Valle, Luis Del; Peruzzi, Francesca

2011-01-01

The Src-homology 3 (SH3) domain is one of the most frequent protein recognition modules (PRMs), being represented in signal transduction pathways and in several pathologies such as cancer and AIDS. Grb2 (growth factor receptor-bound protein 2) is an adaptor protein that contains two SH3 domains and is involved in receptor tyrosine kinase (RTK) signal transduction pathways. The HIV-1 transactivator factor Tat is required for viral replication and it has been shown to bind directly or indirectly to several host proteins, deregulating their functions. In this study, we show interaction between the cellular factor Grb2 and the HIV-1 trans-activating protein Tat. The binding is mediated by the proline-rich sequence of Tat and the SH3 domain of Grb2. As the adaptor protein Grb2 participates in a wide variety of signaling pathways, we characterized at least one of the possible downstream effects of the Tat/Grb2 interaction on the well-known IGF-1R/Raf/MAPK cascade. We show that the binding of Tat to Grb2 impairs activation of the Raf/MAPK pathway, while potentiating the PKA/Raf inhibitory pathway. The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia. PMID:21745501

Gamma-Ray Burst Supernovae as Standardizable Candles

NASA Astrophysics Data System (ADS)

Cano, Z.

2014-10-01

A long-duration gamma-ray burst (GRB) marks the violent end of a massive star. GRBs are rare in the universe, and their progenitor stars are thought to possess unique physical properties such as low metal content and rapid rotation, while the supernovae (SNe) that are associated with GRBs are expected to be highly aspherical. To date, it has been unclear whether GRB-SNe could be used as standardizable candles, with contrasting conclusions found by different teams. In this paper, I present evidence that GRB-SNe have the potential to be used as standardizable candles and show that a statistically significant relation exists between the brightness and width of their decomposed light curves relative to a template SN. Every single nearby spectroscopically identified GRB-SN for which the rest frame and host contributions have been accurately determined follows this relation. Additionally, it is shown that not only GRB-SNe, but perhaps all SNe whose explosions are powered by a central engine may eventually be used as a standardizable candle. Finally, I suggest that the use of GRB-SNe as standardizable candles likely arises from a combination of the viewing angle and similar explosion geometry in each event, the latter of which is influenced by the explosion mechanism of GRB-SNe.

Gamma-Ray Bursts: Lighting Up the High-Redshift Universe

NASA Astrophysics Data System (ADS)

Toy, Vicki Louise

Gamma-ray bursts (GRBs) are the most luminous events in the Universe with Egamma,iso ˜ 1048-54 erg. Leading models hypothesize that GRBs are created from inter- nal collisions within collimated and ultrarelativistic jets. The jets then shock-heat the surrounding material (e.g. interstellar medium) to create GRB afterglows. These afterglows are extremely useful probes of the Universe because long GRBs are (1) bright events that can be used as backlights for absorption studies, (2) able to probe at all redshifts massive stars exist, and (3) transient events that allow us to follow- up on the host galaxies at late times. In this thesis we study the environments of GRBs. We first explore the relationship between GRB and supernova (SN) using a nearby GRB-SN (GRB 130702A/SN 2013dx) at z = 0.145. There are only nine other GRB-SNe that were close enough to have extensive spectroscopic and photometric follow-up of the SN at late times. We create a quasi-bolometic light curve of SN 2013dx and fit an analytical equation to the quasi-bolometric light curve combined with measurements of the photospheric velocity to determine SN parameters: mass of 56Ni, kinetic energy, and ejecta mass. We examine the relationship between SN parameters and E gamma,iso for the 10 well-studied GRB-SNe, but find no correlations despite numerical simulation predictions that the mass of 56Ni should correlate with the degree of asymmetry. We then move to larger distance scales and use GRB afterglows as bright back- lights to study distant galaxies. We examine the galactic environments of Damped Lyman-alpha systems (DLAs; NHI ≥ 1020.3 cm-2 ) identified with GRB afterglows at z ˜ 2 - 6. We use late-time photometry after the GRB afterglow has faded to determine star formation rates (SFRs) from rest-frame ultraviolet measurements or spectral energy distribution (SED) models from multiband photometry. We com- pare our sample's SFRs to a sample of quasars (QSOs) DLA host galaxies. Despite the overlapping NHI and redshift ranges, our GRB-DLA galaxies have much larger SFRs than the QSO-DLA host galaxy sample; this may suggest that the QSO-DLA and GRB-DLA galaxy populations are different. We also compare star formation efficiencies to the local Universe and simulations at z = 3. A large portion of this thesis has focused on the development of a new ground- based GRB afterglow follow-up instrument, the Rapid infrared IMAger-Spectrometer (RIMAS), that will target high-redshift GRB afterglows to study early galaxy envi- ronments. RIMAS covers 0.97-2.37 mum and can simultaneously observe two band-passes in any observing mode: photometry, low-resolution spectroscopy (R ˜ 30), or high-resolution spectroscopy (R ˜ 4000). In particular, this thesis focuses on RIMAS's three detectors: two science grade Teledyne HgCdTe Astronomy Wide Area Infrared Imager with 2K x 2K, Reference Pixels and Guide Mode (H2RG) and a slit-viewer Spitzer Legacy Indium-Antimonide (InSb) array. We describe the detector hardware and characterization in detail and discuss general infrared detector troubleshooting methods at both cryogenic and room temperatures. Several software packages have been developed for RIMAS throughout this thesis work. We introduce RIMAS's quick reduction pipeline that takes raw images from a single acquisition and returns a single result frame. We then present a generalized data reduction pipeline that we have tested on two currently operational photometers. We also describe our detailed and realistic RIMAS throughput models for all three observing modes as well as our online observer calculators with these throughput models. All of our data products are open source and are publicly available on Github repositories with detailed documentation.

Photometric and Spectroscopic Observations of GRB 140629A

NASA Astrophysics Data System (ADS)

Xin, Li-Ping; Zhong, Shu-Qing; Liang, En-Wei; Wang, Jing; Liu, Hao; Zhang, Tian-Meng; Huang, Xiao-Li; Li, Hua-Li; Qiu, Yu-Lei; Han, Xu-Hui; Wei, Jian-Yan

2018-06-01

We present our optical photometric and spectroscopical observations of GRB 140629A. A redshift of z = 2.275 ±0.043 is measured through the metal absorption lines in our spectroscopic data. Using our photometric data and multiple observational data from other telescopes, we show that its optical light curve is well interpreted with the standard forward shock models in the thin shell case. Its optical–X-ray afterglow spectrum is jointly fitted with a single power-law function, yielding a photon index of ‑1.90 ± 0.05. The optical extinction and neutral hydrogen absorption of the gamma-ray burst (GRB) host galaxy are negligible. The fit to the light curve with the standard models shows that the ambient density is 60 ± 9 cm‑3 and the GRB radiating efficiency is as low as ∼0.24%, likely indicating a baryonic-dominated ejecta of this GRB. This burst agrees well with the {L}{{p},{iso}}{--}{E}p{\\prime }{--}{{{Γ }}}0 relation, but confidently violates those empirical relations involving geometric corrections (or jet break time). This gives rise to an issue of the possible selection effect on these relations since the jet opening angle of this GRB is extremely narrow (0.04 rad).

Fermi Observations of GRB 090510: A Short Hard Gamma-Ray Burst with an Additional, Hard Power-Law Component from 10 keV to GeV Energies

DOE PAGES

Ackermann, M.; Asano, K.; Atwood, W. B.; ...

2010-05-27

We present detailed observations of the bright short-hard gamma-ray burst GRB 090510 made with the Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) on board the Fermi observatory. GRB 090510 is the first burst detected by the LAT that shows strong evidence for a deviation from a Band spectral fitting function during the prompt emission phase. The time-integrated spectrum is fit by the sum of a Band function with E peak = 3.9 ± 0.3 MeV, which is the highest yet measured, and a hard power-law component with photon index –1.62 ± 0.03 that dominates the emission below ≈20more » keV and above ≈100 MeV. The onset of the high-energy spectral component appears to be delayed by ~0.1 s with respect to the onset of a component well fit with a single Band function. A faint GBM pulse and a LAT photon are detected 0.5 s before the main pulse. During the prompt phase, the LAT detected a photon with energy 30.5 +5.8 –2.6 GeV, the highest ever measured from a short GRB. Observation of this photon sets a minimum bulk outflow Lorentz factor, Γ≳ 1200, using simple γγ opacity arguments for this GRB at redshift z = 0.903 and a variability timescale on the order of tens of ms for the ≈100 keV-few MeV flux. Stricter high confidence estimates imply Γ ≳ 1000 and still require that the outflows powering short GRBs are at least as highly relativistic as those of long-duration GRBs. Finally, implications of the temporal behavior and power-law shape of the additional component on synchrotron/synchrotron self-Compton, external-shock synchrotron, and hadronic models are considered.« less

GRB 971214

NASA Astrophysics Data System (ADS)

Kulkarni, S. R.; Adelberger, K. L.; Bloom, J. S.; Kundic, T.; Lubin, L.

1998-01-01

On December 28, 1997, Kundic and Lubin obtained spectra of the optical transient of GRB 971214 (IAUC #6788) with the Low Resolution Imaging Spectrograph (LRIS) mounted on the Keck II telescope. The seeing conditions were excellent. If the transient continued the power-law decay as indicated by the data from Halpern et al. (IAUC #6788) then by this epoch the light at this position should be dominated by the host (cf. Kulkarni et al. GCN #27; ATEL #5).

Structure and dynamics of star-forming galaxies across the history of the Universe using GRBs

NASA Astrophysics Data System (ADS)

Thöne, Christina; Fynbo, Johan; de Ugarte Postigo, Antonio

2015-08-01

Gamma-ray bursts are exploding massive stars and some of the most luminous explosions in the Universe. They can serve as powerful light houses that probe the structure and abundances of the dense ISM in their hosts at almost any redshift and not accessible by other types of observations, e.g. using quasars. Since 2009 our collaboration has collected UV to nIR medium-resolution spectra of over 70 GRB afterglows using the ESO/VLT X-shooter spectrograph. Our sample covers a redshift range from 0.06 to 6.3 allowing us to study the dynamics of the ISM in star-forming galaxies from the nearby Universe out to the epoch of reionization and for the first time in a statistically sound way. Absorption lines usually show a rich structure of different components due to galaxy dynamics, turbulences or in-/outflows and different ionization levels seem to arise from different regions in the host. Fine-structure lines some of which are uniquely observed in GRB hosts are excited in the dense regions close to the GRB site itself. For some host with z < 3 we can also simultaenously observe emission lines from the hot ISM, comparing the origin of hot and cold gas within the same galaxy. The large wavelength coverage of the sample gives us the unique opportunity to study the evolution of gas dynamics across most of the time galaxies have existed, how the gas structure changed over time and what is the importance and consistency of in- and ouflows. Here we will present the X-shooter GRB afterglow sample, our results on the study of absorption and emission line features and compare the observed structures with theoretical models of galaxies to get a unique insight on the distrubution and dynamics of the ISM in starforming galaxies at any redshift.

The extraordinarily bright optical afterglow of GRB 991208 and its host galaxy

NASA Astrophysics Data System (ADS)

Castro-Tirado, A. J.; Sokolov, V. V.; Gorosabel, J.; Castro Cerón, J. M.; Greiner, J.; Wijers, R. A. M. J.; Jensen, B. L.; Hjorth, J.; Toft, S.; Pedersen, H.; Palazzi, E.; Pian, E.; Masetti, N.; Sagar, R.; Mohan, V.; Pandey, A. K.; Pandey, S. B.; Dodonov, S. N.; Fatkhullin, T. A.; Afanasiev, V. L.; Komarova, V. N.; Moiseev, A. V.; Hudec, R.; Simon, V.; Vreeswijk, P.; Rol, E.; Klose, S.; Stecklum, B.; Zapatero-Osorio, M. R.; Caon, N.; Blake, C.; Wall, J.; Heinlein, D.; Henden, A.; Benetti, S.; Magazzù, A.; Ghinassi, F.; Tommasi, L.; Bremer, M.; Kouveliotou, C.; Guziy, S.; Shlyapnikov, A.; Hopp, U.; Feulner, G.; Dreizler, S.; Hartmann, D.; Boehnhardt, H.; Paredes, J. M.; Martí, J.; Xanthopoulos, E.; Kristen, H. E.; Smoker, J.; Hurley, K.

2001-05-01

Broad-band optical observations of the extraordinarily bright optical afterglow of the intense gamma-ray burst GRB 991208 started ~2.1 days after the event and continued until 4 Apr. 2000. The flux decay constant of the optical afterglow in the R-band is -2.30 +/- 0.07 up to ~5 days, which is very likely due to the jet effect, and it is followed by a much steeper decay with constant -3.2 +/- 0.2, the fastest one ever seen in a GRB optical afterglow. A negative detection in several all-sky films taken simultaneously with the event, that otherwise would have reached naked eye brightness, implies either a previous additional break prior to ~2 days after the occurrence of the GRB (as expected from the jet effect) or a maximum, as observed in GRB 970508. The existence of a second break might indicate a steepening in the electron spectrum or the superposition of two events, resembling GRB 000301C. Once the afterglow emission vanished, contribution of a bright underlying supernova was found on the basis of the late-time R-band measurements, but the light curve is not sufficiently well sampled to rule out a dust echo explanation. Our redshift determination of z = 0.706 indicates that GRB 991208 is at 3.7 Gpc (for Ho = 60 km s-1 Mpc-1, OMEGAo = 1 and LAMDAo = 0), implying an isotropic energy release of 1.15 x 1053 erg which may be relaxed by beaming by a factor >102. Precise astrometry indicates that the GRB coincides within 0.2" with the host galaxy, thus supporting a massive star origin. The absolute magnitude of the galaxy is MB = -18.2, well below the knee of the galaxy luminosity function and we derive a star-forming rate of (11.5 +/- 7.1) Msun yr-1, which is much larger than the present-day rate in our Galaxy. The quasi-simultaneous broad-band photometric spectral energy distribution of the afterglow was determined ~3.5 day after the burst (Dec. 12.0) implying a cooling frequency nuc below the optical band, i.e. supporting a jet model with p = -2.30 as the index of the power-law electron distribution.

GRB 090417B and its Host Galaxy: A Step Towards an Understanding of Optically-Dark Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Holland, Stephen T.; Sbarufatti, Boris; Shen, Rongfeng; Schady, Patricia; Cummings, Jay R.; Fonseca, Emmanuel; Fynbo, Johan P. U.; Jakobsson, Pall; Leitet, Elisabet; Linne, Staffan;

CONNECTING GRBs AND ULIRGs: A SENSITIVE, UNBIASED SURVEY FOR RADIO EMISSION FROM GAMMA-RAY BURST HOST GALAXIES AT 0 < z < 2.5

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perley, D. A.; Perley, R. A.; Hjorth, J.

2015-03-10

Luminous infrared galaxies and submillimeter galaxies contribute significantly to stellar mass assembly and provide an important test of the connection between the gamma-ray burst (GRB) rate and that of overall cosmic star formation. We present sensitive 3 GHz radio observations using the Karl G. Jansky Very Large Array of 32 uniformly selected GRB host galaxies spanning a redshift range from 0 < z < 2.5, providing the first fully dust- and sample-unbiased measurement of the fraction of GRBs originating from the universe's most bolometrically luminous galaxies. Four galaxies are detected, with inferred radio star formation rates (SFRs) ranging between 50 and 300 Mmore » {sub ☉} yr{sup –1}. Three of the four detections correspond to events consistent with being optically obscured 'dark' bursts. Our overall detection fraction implies that between 9% and 23% of GRBs between 0.5 < z < 2.5 occur in galaxies with S {sub 3GHz} > 10 μJy, corresponding to SFR > 50 M {sub ☉} yr{sup –1} at z ∼ 1 or >250 M {sub ☉} yr{sup –1} at z ∼ 2. Similar galaxies contribute approximately 10%-30% of all cosmic star formation, so our results are consistent with a GRB rate that is not strongly biased with respect to the total SFR of a galaxy. However, all four radio-detected hosts have stellar masses significantly lower than IR/submillimeter-selected field galaxies of similar luminosities. We suggest that the GRB rate may be suppressed in metal-rich environments but independently enhanced in intense starbursts, producing a strong efficiency dependence on mass but little net dependence on bulk galaxy SFR.« less

Possible role of gamma ray bursts on life extinction in the universe.

PubMed

Piran, Tsvi; Jimenez, Raul

2014-12-05

As a copious source of gamma rays, a nearby galactic gamma ray burst (GRB) can be a threat to life. Using recent determinations of the rate of GRBs, their luminosity function, and properties of their host galaxies, we estimate the probability that a life-threatening (lethal) GRB would take place. Amongst the different kinds of GRBs, long ones are most dangerous. There is a very good chance (but no certainty) that at least one lethal GRB took place during the past 5 gigayears close enough to Earth as to significantly damage life. There is a 50% chance that such a lethal GRB took place during the last 500×10^{6}  years, causing one of the major mass extinction events. Assuming that a similar level of radiation would be lethal to life on other exoplanets hosting life, we explore the potential effects of GRBs to life elsewhere in the Galaxy and the Universe. We find that the probability of a lethal GRB is much larger in the inner Milky Way (95% within a radius of 4 kpc from the galactic center), making it inhospitable to life. Only at the outskirts of the Milky Way, at more than 10 kpc from the galactic center, does this probability drop below 50%. When considering the Universe as a whole, the safest environments for life (similar to the one on Earth) are the lowest density regions in the outskirts of large galaxies, and life can exist in only ≈10% of galaxies. Remarkably, a cosmological constant is essential for such systems to exist. Furthermore, because of both the higher GRB rate and galaxies being smaller, life as it exists on Earth could not take place at z>0.5. Early life forms must have been much more resilient to radiation.

A Nontriggered Burst Supplement to the BATSE Gamma-Ray Burst Catalogs

NASA Technical Reports Server (NTRS)

Kommers, Jefferson M.; Lewin, Walter H. G.; Kouveliotou, Chryssa; vanParadijs, Jan; Pendleton, Geoffrey N.; Meegan, Charles A.; Fishman, Gerald J.

2001-01-01

The Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory detects gamma-ray bursts (GRBs) with a real-time burst detection (or "trigger") system running onboard the spacecraft. Under some circumstances, however, a GRB may not activate the on-board burst trigger. For example, the burst may be too faint to exceed the on-board detection threshold, or it may occur while the on-board burst trigger is disabled for technical reasons. This paper describes a catalog of 873 "nontriggered" GRBs that were detected in a search of the archival continuous data from BATSE recorded between 1991 December 9.0 and 1997 December 17.0. For each burst, the catalog gives an estimated source direction, duration, peak flux, and fluence. Similar data are presented for 50 additional bursts of unknown origin that were detected in the 25-50 keV range; these events may represent the low-energy "tail" of the GRB spectral distribution. This catalog increases the number of GRBs detected with BATSE by 48% during the time period covered by the search.

A Non-Triggered Burst Supplement to the BATSE Gamma-Ray Burst Catalogs

NASA Technical Reports Server (NTRS)

Kommers, J.; Lewin, W. H.; Kouveliotou, C.; vanParadijs, J.; Pendleton, G. N.; Meegan, C. A.; Fishman, G. J.

1998-01-01

The Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory detects gamma-ray bursts (GRBs) with a real-time burst detection (or "trigger") system running onboard the spacecraft. Under some circumstances, however, a GRB may not activate the onboard burst trigger. For example, the burst may be too faint to exceed the onboard detection threshold, or it may occur while the onboard burst trigger is disabled for technical reasons. This paper is a catalog of such "non-triggered" GRBs that were detected in a search of the archival continuous data from BATSE. It lists 873 non-triggered bursts that were recorded between 1991 December 9.0 and 1997 December 17.0. For each burst, the catalog gives an estimated source direction, duration, peak flux, and fluence. Similar data are presented for 50 additional bursts of unknown origin that were detected in the 25-50 keV range; these events may represent the low-energy "tail" of the GRB spectral distribution. This catalog increases the number of GRBs detected with BATSE by 48% during the time period covered by the search.

ASTROBIOLOGICAL EFFECTS OF GAMMA-RAY BURSTS IN THE MILKY WAY GALAXY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gowanlock, Michael G., E-mail: gowanloc@mit.edu

A planet having protective ozone within the collimated beam of a gamma-ray burst (GRB) may suffer ozone depletion, potentially causing a mass extinction event to existing life on a planet’s surface and oceans. We model the dangers of long GRBs to planets in the Milky Way and utilize a static statistical model of the Galaxy, which matches major observable properties, such as the inside-out star formation history (SFH), metallicity evolution, and three-dimensional stellar number density distribution. The GRB formation rate is a function of both the SFH and metallicity. However, the extent to which chemical evolution reduces the GRB ratemore » over time in the Milky Way is still an open question. Therefore, we compare the damaging effects of GRBs to biospheres in the Milky Way using two models. One model generates GRBs as a function of the inside-out SFH. The other model follows the SFH, but generates GRB progenitors as a function of metallicity, thereby favoring metal-poor host regions of the Galaxy over time. If the GRB rate only follows the SFH, the majority of the GRBs occur in the inner Galaxy. However, if GRB progenitors are constrained to low-metallicity environments, then GRBs only form in the metal-poor outskirts at recent epochs. Interestingly, over the past 1 Gyr, the surface density of stars (and their corresponding planets), which survive a GRB is still greatest in the inner galaxy in both models. The present-day danger of long GRBs to life at the solar radius ( R {sub ⊙} = 8 kpc) is low. We find that at least ∼65% of stars survive a GRB over the past 1 Gyr. Furthermore, when the GRB rate was expected to have been enhanced at higher redshifts, such as z ≳ 0.5, our results suggest that a large fraction of planets would have survived these lethal GRB events.« less

The Very Red Afterglow of GRB 000418: Further Evidence for Dust Extinction in a Gamma-Ray Burst Host Galaxy

NASA Astrophysics Data System (ADS)

Klose, S.; Stecklum, B.; Masetti, N.; Pian, E.; Palazzi, E.; Henden, A. A.; Hartmann, D. H.; Fischer, O.; Gorosabel, J.; Sánchez-Fernández, C.; Butler, D.; Ott, Th.; Hippler, S.; Kasper, M.; Weiss, R.; Castro-Tirado, A.; Greiner, J.; Bartolini, C.; Guarnieri, A.; Piccioni, A.; Benetti, S.; Ghinassi, F.; Magazzú, A.; Hurley, K.; Cline, T.; Trombka, J.; McClanahan, T.; Starr, R.; Goldsten, J.; Gold, R.; Mazets, E.; Golenetskii, S.; Noeske, K.; Papaderos, P.; Vreeswijk, P. M.; Tanvir, N.; Oscoz, A.; Muñoz, J. A.; Castro Cerón, J. M.

2000-12-01

We report near-infrared and optical follow-up observations of the afterglow of the GRB 000418 starting 2.5 days after the occurrence of the burst and extending over nearly 7 weeks. GRB 000418 represents the second case for which the afterglow was initially identified by observations in the near-infrared. During the first 10 days its R-band afterglow was well characterized by a single power-law decay with a slope of 0.86. However, at later times the temporal evolution of the afterglow flattens with respect to a simple power-law decay. Attributing this to an underlying host galaxy, we find its magnitude to be R=23.9 and an intrinsic afterglow decay slope of 1.22. The afterglow was very red with R-K~4 mag. The observations can be explained by an adiabatic, spherical fireball solution and a heavy reddening due to dust extinction in the host galaxy. This supports the picture that (long) bursts are associated with events in star-forming regions. Based on observations collected at the Bologna Astronomical Observatory in Loiano, Italy; at the TNG, Canary Islands, Spain; at the German-Spanish Astronomical Centre, Calar Alto, operated by the Max-Planck-Institut for Astronomy, Heidelberg, jointly with the Spanish National Commission for Astronomy; at the US Naval Observatory; and at the UK Infrared Telescope.

A Deep Search with the Hubble Space Telescope for Late-Time Supernova Signatures in the Hosts of XRF 011030 and XRF 020427

NASA Technical Reports Server (NTRS)

Levan, Andrew; Patel, Sandeep; Kouveliotou, Chryssa; Fruchter, Andrew; Rhoads, James; Rol, Evert; Ramirez-Ruiz, Enrico; Gorosabel, Javier; Hiorth, Jens; Wijers, Ralph

2005-01-01

X-ray flashes (XRFs) are, like gamma-ray bursts (GRBs), thought to signal the collapse of massive stars in distant galaxies. Many models posit that the isotropic equivalent energies of XRFs are lower than those for GRBs, such that they are visible fiom a reduced range of distances when compared with GRBs. Here we present the results of two-epoch Hubble Space Telescope imaging of two XRFs. These images, taken approximately 45 and 200 days postburst, reveal no evidence of an associated supernova in either case. Supernovae such as SN 1998bw would have been visible out to z approximately 1.5 in each case, while fainter supernovae such as SN 2002ap would have been visible to z approximately 1. If the XRFs lie at such large distances, their energies would not fit the observed correlation between the GRB peak energy and isotropic energy release (E(sub p) proportional to E(sub iso)(sup 1/2), in which soft bursts are less energetic. We conclude that, should these XRFs reside at low redshifts (z less than 0.6), either their line of sight is heavily extinguished, they are associated with extremely faint supernovae, or, unlike GRBs, these XRFs do not have temporally coincident supernovae.

Sweating the small stuff: simulating dwarf galaxies, ultra-faint dwarf galaxies, and their own tiny satellites

NASA Astrophysics Data System (ADS)

Wheeler, Coral; Oñorbe, Jose; Bullock, James S.; Boylan-Kolchin, Michael; Elbert, Oliver D.; Garrison-Kimmel, Shea; Hopkins, Philip F.; Kereš, Dušan

2015-10-01

We present Feedback in Realistic Environment (FIRE)/GIZMO hydrodynamic zoom-in simulations of isolated dark matter haloes, two each at the mass of classical dwarf galaxies (Mvir ≃ 1010 M⊙) and ultra-faint galaxies (Mvir ≃ 109 M⊙), and with two feedback implementations. The resulting central galaxies lie on an extrapolated abundance matching relation from M⋆ ≃ 106 to 104 M⊙ without a break. Every host is filled with subhaloes, many of which form stars. Each of our dwarfs with M⋆ ≃ 106 M⊙ has 1-2 well-resolved satellites with M⋆ = 3-200 × 103 M⊙. Even our isolated ultra-faint galaxies have star-forming subhaloes. If this is representative, dwarf galaxies throughout the Universe should commonly host tiny satellite galaxies of their own. We combine our results with the Exploring the Local Volume in Simulations (ELVIS) simulations to show that targeting ˜ 50 kpc regions around nearby isolated dwarfs could increase the chances of discovering ultra-faint galaxies by ˜35 per cent compared to random pointings, and specifically identify the region around the Phoenix dwarf galaxy as a good potential target. The well-resolved ultra-faint galaxies in our simulations (M⋆ ≃ 3-30 × 103 M⊙) form within Mpeak ≃ 0.5-3 × 109 M⊙ haloes. Each has a uniformly ancient stellar population ( > 10 Gyr) owing to reionization-related quenching. More massive systems, in contrast, all have late-time star formation. Our results suggest that Mhalo ≃ 5 × 109 M⊙ is a probable dividing line between haloes hosting reionization `fossils' and those hosting dwarfs that can continue to form stars in isolation after reionization.

SN 2010ay Is a Luminous and Broad-Lined Type Ic Supernova Within a Low-Metallicity Host Galaxy

NASA Technical Reports Server (NTRS)

Sanders, N. E.; Soderberg, A. M.; Valenti, S.; Foley, R. J.; Chornock, R.; Chomiuk, L.; Berger, E.; Smartt, S.; Hurley, K.; Barthelmy, S. D.;

On the Afterglow and Progenitor of FRB 150418

NASA Astrophysics Data System (ADS)

Zhang, Bing

2016-05-01

Keane et al. recently detected a fading radio source following FRB 150418, leading to the identification of a putative host galaxy at z = 0.492 ± 0.008. Assuming that the fading source is the afterglow of FRB 150418, I model the afterglow and constrain the isotropic energy of the explosion to be a few 1050 erg, comparable to that of a short-duration gamma-ray burst (GRB). The outflow may have a jet opening angle of ˜0.22 rad, so that the beaming-corrected energy is below 1049 erg. The results rule out most fast radio burst (FRB) progenitor models for this FRB, but may be consistent with either of the following two scenarios. The first scenario invokes a merger of an NS-NS binary, which produced an undetected short GRB and a supra-massive neutron star, which subsequently collapsed into a black hole, probably hundreds of seconds after the short GRB. The second scenario invokes a merger of a compact star binary (BH-BH, NS-NS, or BH-NS) system whose pre-merger dynamical magnetospheric activities made the FRB, which is followed by an undetected short GRB-like transient. The gravitational-wave (GW) event GW 150914 would be a sister of FRB 150418 in this second scenario. In both cases, one expects an exciting prospect of GW/FRB/GRB associations.

Highly-ionized metals as probes of the circumburst gas in the natal regions of gamma-ray bursts

NASA Astrophysics Data System (ADS)

Heintz, K. E.; Watson, D.; Jakobsson, P.; Fynbo, J. P. U.; Bolmer, J.; Arabsalmani, M.; Cano, Z.; Covino, S.; D'Elia, V.; Gomboc, A.; Japelj, J.; Kaper, L.; Krogager, J.-K.; Pugliese, G.; Sánchez-Ramírez, R.; Selsing, J.; Sparre, M.; Tanvir, N. R.; Thöne, C. C.; de Ugarte Postigo, A.; Vergani, S. D.

2018-06-01

We present here a survey of high-ionization absorption lines in the afterglow spectra of long-duration gamma-ray bursts (GRBs) obtained with the VLT/X-shooter spectrograph. Our main goal is to investigate the circumburst medium in the natal regions of GRBs. Our primary focus is on the N V λλ 1238,1242 line transitions, but we also discuss other high-ionization lines such as O VI, C IV and Si IV. We find no correlation between the column density of N V and the neutral gas properties such as metallicity, H I column density and dust depletion, however the relative velocity of N V, typically a blueshift with respect to the neutral gas, is found to be correlated with the column density of H I. This may be explained if the N V gas is part of an H II region hosting the GRB, where the region's expansion is confined by dense, neutral gas in the GRB's host galaxy. We find tentative evidence (at 2σ significance) that the X-ray derived column density, NH, X, may be correlated with the column density of N V, which would indicate that both measurements are sensitive to the column density of the gas located in the vicinity of the GRB. We investigate the scenario where N V (and also O VI) is produced by recombination after the corresponding atoms have been stripped entirely of their electrons by the initial prompt emission, in contrast to previous models where highly-ionized gas is produced by photoionization from the GRB afterglow.

The 2175 Å Extinction Feature in the Optical Afterglow Spectrum of GRB 180325A at z = 2.25

NASA Astrophysics Data System (ADS)

Zafar, T.; Heintz, K. E.; Fynbo, J. P. U.; Malesani, D.; Bolmer, J.; Ledoux, C.; Arabsalmani, M.; Kaper, L.; Campana, S.; Starling, R. L. C.; Selsing, J.; Kann, D. A.; de Ugarte Postigo, A.; Schweyer, T.; Christensen, L.; Møller, P.; Japelj, J.; Perley, D.; Tanvir, N. R.; D’Avanzo, P.; Hartmann, D. H.; Hjorth, J.; Covino, S.; Sbarufatti, B.; Jakobsson, P.; Izzo, L.; Salvaterra, R.; D’Elia, V.; Xu, D.

2018-06-01

The ultraviolet (UV) extinction feature at 2175 Å is ubiquitously observed in the Galaxy but is rarely detected at high redshifts. Here we report the spectroscopic detection of the 2175 Å bump on the sightline to the γ-ray burst (GRB) afterglow GRB 180325A at z = 2.2486, the only unambiguous detection over the past 10 years of GRB follow-up, at four different epochs with the Nordic Optical Telescope (NOT) and the Very Large Telescope (VLT)/X-shooter. Additional photometric observations of the afterglow are obtained with the Gamma-Ray burst Optical and Near-Infrared Detector (GROND). We construct the near-infrared to X-ray spectral energy distributions (SEDs) at four spectroscopic epochs. The SEDs are well described by a single power law and an extinction law with R V ≈ 4.4, A V ≈ 1.5, and the 2175 Å extinction feature. The bump strength and extinction curve are shallower than the average Galactic extinction curve. We determine a metallicity of [Zn/H] > ‑0.98 from the VLT/X-shooter spectrum. We detect strong neutral carbon associated with the GRB with equivalent width of W r(λ 1656) = 0.85 ± 0.05. We also detect optical emission lines from the host galaxy. Based on the Hα emission-line flux, the derived dust-corrected star formation rate is ∼46 ± 4 M ⊙ yr‑1 and the predicted stellar mass is log M */M ⊙ ∼ 9.3 ± 0.4, suggesting that the host galaxy is among the main-sequence star-forming galaxies. Based on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO program 0100.D‑0649(A).

Host Galaxy Spectra of Stripped SN from the Palomar Transient Factory: SN Progenitor Diagnostics and the SN-GRB Connection

NASA Astrophysics Data System (ADS)

Modjaz, Maryam; Gal-Yam, Avishay; Arcavi, Iair

2012-02-01

Stripped core-collapse supernovae (Stripped SNe) are powerful cosmic engines that energize and enrich the ISM and that sometimes accompany GRBs, but the exact mass and metallicity range of their massive progenitors is not known, nor the detailed physics of the explosion. We propose to continue conducting the first uniform and statistically significant study of host galaxies of 60 stripped SNe from the same innovative, homogeneous and galaxy-unbiased survey Palomar Transient Factory in order to determine the environmental conditions that influence the various kinds of massive stellar deaths. By obtaining spectra of the immediate host environments of our sample of stripped SN, we will (1) measure local abundances in order to differentiate between the two progenitor scenarios for stripped SN and (2) derive stellar population ages, masses and star formation histories via detailed stellar population synthesis models. Moreover, we will test if natal chemical abundance has effects on basic SN characteristics, such as peak luminosity. Any observed trends will have ramifications on SN and GRB explosion models and imply important demographic SN considerations. Our dataset will provide a crucial complimentary set to host galaxy studies of long-duration GRBs and pave the way for host studies of transients and SN found via upcoming surveys such as LSST.

The VLT/X-shooter GRB afterglow legacy survey

NASA Astrophysics Data System (ADS)

Kaper, Lex; Fynbo, Johan P. U.; Pugliese, Vanna; van Rest, Daan

2017-11-01

The Swift satellite allows us to use gamma-ray bursts (GRBs) to peer through the hearts of star forming galaxies through cosmic time. Our open collaboration, representing most of the active European researchers in this field, builds a public legacy sample of GRB X-shooter spectroscopy while Swift continues to fly. To date, our spectroscopy of more than 100 GRB afterglows covers a redshift range from 0.059 to about 8 (Tanvir et al. 2009, Nature 461, 1254), with more than 20 robust afterglow-based metallicity measurements (over a redshift range from 1.7 to 5.9). With afterglow spectroscopy (throughout the electromagnetic spectrum from X-rays to the sub-mm) we can hence characterize the properties of star-forming galaxies over cosmic history in terms of redshift, metallicity, molecular content, ISM temperature, UV-flux density, etc.. These observations provide key information on the final evolution of the most massive stars collapsing into black holes, with the potential of probing the epoch of the formation of the first (very massive) stars. VLT/X-shooter (Vernet et al. 2011, A&A 536, A105) is in many ways the ideal GRB follow-up instrument and indeed GRB follow-up was one of the primary science cases behind the instrument design and implementation. Due to the wide wavelength coverage of X-shooter, in the same observation one can detect molecular H2 absorption near the atmospheric cut-off and many strong emission lines from the host galaxy in the near-infrared (e.g., Friis et al. 2015, MNRAS 451, 167). For example, we have measured a metallicity of 0.1 Z ⊙ for GRB 100219A at z = 4.67 (Thöne et al. 2013, MNRAS 428, 3590), 0.02 Z ⊙ for GRB 111008A at z = 4.99 (Sparre et al. 2014, ApJ 785, 150) and 0.05 Z ⊙ for GRB 130606A at z = 5.91 (Hartoog et al. 2015, A&A 580, 139). In the latter, the very high value of [Al/Fe]=2.40 +/- 0.78 might be due to a proton capture process and may be a signature of a previous generation of massive (perhaps even the first) stars. Reconciling the abundance patterns of GRB absorbers, other types of absorbers (in particular QSO DLAs), and old stars in the Local Group is an important long-term goal of this program (see Sparre et al. 2014, ApJ 785, 150). Metallicities are also measured from host emission lines (Krühler et al. 2015, A&A 581, A125). GRB spectroscopy also allows us to determine the dust content of their environments, both through analysis of the depletion pattern and the measurement of the associated extinction (Japelj et al. 2015, A&A 451, 2050). This way one can quantify the dust-to-metals ratio and its evolution with redshift. The detection of GRBs at z > 6 shows that GRBs have become competitive as a tool to identifying galaxies at the highest redshifts and unsurpassed in providing detailed abundance information via absorption line spectroscopy.

Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1

PubMed Central

Deng, Haoyu; Fung, Gabriel; Shi, Junyan; Xu, Suowen; Wang, Chen; Yin, Meimei; Hou, Jun; Zhang, Jingchun; Jin, Zheng-Gen; Luo, Honglin

2015-01-01

Coxsackievirus B3 (CVB3), an important human causative pathogen for viral myocarditis, pancreatitis, and meningitis, has evolved different strategies to manipulate the host signaling machinery to ensure successful viral infection. We previously revealed a crucial role for the ERK1/2 signaling pathway in regulating viral infectivity. However, the detail mechanism remains largely unknown. Grb2-associated binder 1 (GAB1) is an important docking protein responsible for intracellular signaling assembly and transduction. In this study, we demonstrated that GAB1 was proteolytically cleaved after CVB3 infection at G175 and G436 by virus-encoded protease 2Apro, independent of caspase activation. Knockdown of GAB1 resulted in a significant reduction of viral protein expression and virus titers. Moreover, we showed that virus-induced cleavage of GAB1 is beneficial to viral growth as the N-terminal proteolytic product of GAB1 (GAB1-N1–174) further enhances ERK1/2 activation and promotes viral replication. Our results collectively suggest that CVB3 targets host GAB1 to generate a GAB1-N1–174 fragment that enhances viral infectivity, at least in part, via activation of the ERK pathway. The findings in this study suggest a novel mechanism that CVB3 employs to subvert the host signaling and facilitate consequent viral replication.—Deng, H., Fung, G., Shi, J., Xu, S., Wang, C., Yin, M., Hou, J., Zhang, J., Jin, Z.-G., Luo, H. Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1. PMID:26183772

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, D.; Krühler, T.; Hjorth, J.

Long-duration gamma-ray bursts (GRBs) at z < 1 are found in most cases to be accompanied by bright, broad-lined Type Ic supernovae (SNe Ic-BL). The highest-energy GRBs are mostly located at higher redshifts, where the associated SNe are hard to detect observationally. Here, we present early and late observations of the optical counterpart of the very energetic GRB 130427A. Despite its moderate redshift, z = 0.3399 ± 0.0002, GRB 130427A is at the high end of the GRB energy distribution, with an isotropic-equivalent energy release of E{sub iso} ∼ 9.6 × 10{sup 53} erg, more than an order of magnitudemore » more energetic than other GRBs with spectroscopically confirmed SNe. In our dense photometric monitoring, we detect excess flux in the host-subtracted r-band light curve, consistent with that expected from an emerging SN, ∼0.2 mag fainter than the prototypical SN 1998bw. A spectrum obtained around the time of the SN peak (16.7 days after the GRB) reveals broad undulations typical of SNe Ic-BL, confirming the presence of an SN, designated SN 2013cq. The spectral shape and early peak time are similar to those of the high expansion velocity SN 2010bh associated with GRB 100316D. Our findings demonstrate that high-energy, long-duration GRBs, commonly detected at high redshift, can also be associated with SNe Ic-BL, pointing to a common progenitor mechanism.« less

Host Galaxy Spectra of Stripped SN from the Palomar Transient Factory: SN Progenitor Diagnostics and the SN-GRB Connection

NASA Astrophysics Data System (ADS)

Modjaz, Maryam; Gal-Yam, Avishay; Arcavi, Iair

2011-02-01

Stripped core-collapse supernovae (Stripped SN) are powerful cosmic engines that energize and enrich the ISM and that sometimes accompany GRBs, but the exact mass and metallicity range of their massive progenitors is not known, nor the detailed physics of the explosion. With the harvest of 50 stripped SN from the innovative survey Palomar Transient Factory, we propose to conduct the first uniform and statistically significant study with SN from the same homogeneous and galaxy-unbiased survey in order to determine the environmental conditions that influence the various kinds of massive stellar deaths. By obtaining spectra of the immediate host environments of our sample of stripped SN, we will (1) measure local abundances in order to differentiate between the two progenitor scenarios for stripped SN and (2) derive stellar population ages, masses and star formation histories via detailed stellar population synthesis models. Moreover, we will test if natal chemical abundance has effects on basic SN characteristics, such as peak luminosity. Any observed trends will have ramifications on SN and GRB explosion models and imply important demographic SN considerations. Our dataset will provide a crucial complimentary set to host galaxy studies of long-duration GRBs and pave the way for host studies of transients and SN found via upcoming surveys such as LSST.

Mesenchymal stem cells express serine protease inhibitor to evade the host immune response

PubMed Central

El Haddad, Najib; Heathcote, Dean; Moore, Robert; Yang, Sunmi; Azzi, Jamil; Mfarrej, Bechara; Atkinson, Mark; Sayegh, Mohamed H.; Lee, Jeng-Shin; Ashton-Rickardt, Philip G.

2011-01-01

Clinical trials using mesenchymal stem cells (MSCs) have been initiated worldwide. An improved understanding of the mechanisms by which allogeneic MSCs evade host immune responses is paramount to regulating their survival after administration. This study has focused on the novel role of serine protease inhibitor (SPI) in the escape of MSCs from host immunosurveillance through the inhibition of granzyme B (GrB). Our data indicate bone marrow–derived murine MSCs express SPI6 constitutively. MSCs from mice deficient for SPI6 (SPI6−/−) exhibited a 4-fold higher death rate by primed allogeneic cytotoxic T cells than did wild-type MSCs. A GrB inhibitor rescued SPI6−/− MSCs from cytotoxic T-cell killing. Transduction of wild-type MSCs with MigR1-SPI6 also protected MSCs from cytotoxic T cell–mediated death in vitro. In addition, SPI6−/− MSCs displayed a shorter lifespan than wild-type MSCs when injected into an allogeneic host. We conclude that SPI6 protects MSCs from GrB-mediated killing and plays a pivotal role in their survival in vivo. Our data could serve as a basis for future SPI-based strategies to regulate the survival and function of MSCs after administration and to enhance the efficacy of MSC-based therapy for diseases. PMID:21076046

A catalogue of faint local radio AGN and the properties of their host galaxies

NASA Astrophysics Data System (ADS)

Lofthouse, E. K.; Kaviraj, S.; Smith, D. JB; Hardcastle, M. J.

2018-05-01

We present a catalogue of local (z < 0.1) galaxies that contain faint AGN. We select these objects by identifying galaxies that exhibit a significant excess in their radio luminosities, compared to what is expected from the observed levels of star-formation activity in these systems. This is achieved by comparing the optical (spectroscopic) star formation rate (SFR) to the 1.4 GHz luminosity measured from the FIRST survey. The majority of the AGN identified in this study are fainter than those in previous work, such as in the Best and Heckman (2012) catalogue. We show that these faint AGN make a non-negligible contribution to the radio luminosity function at low luminosities (below 1022.5 W Hz-1), and host ˜13 per cent of the local radio luminosity budget. Their host galaxies are predominantly high stellar-mass systems (with a median stellar mass of 1011M⊙), are found across a range of environments (but typically in denser environments than star-forming galaxies) and have early-type morphologies. This study demonstrates a general technique to identify AGN in galaxy populations where reliable optical SFRs can be extracted using spectro-photometry and where radio data are also available so that a radio excess can be measured. Our results also demonstrate that it is unsafe to infer SFRs from radio emission alone, even if bright AGN have been excluded from a sample, since there is a significant population of faint radio AGN which may contaminate the radio-derived SFRs.

Detection of GRB 060927 at zeta = 5.47: Implications for the Use of Gamma-Ray Bursts as Probes of the End of the Dark Ages

NASA Technical Reports Server (NTRS)

Ruiz-Velasco, A. E.; Swan, H.; Troja, E.; Malesani, D.; Fynbo, J. P. U.; Sterling, R. L. C.; Xu, D.; Aharonian, F.; Akerlof, C.; Andersen, M. I.;

The Fast Evolution of SN 2010bh Associated with XRF 100316D

NASA Technical Reports Server (NTRS)

Olivares E., F.; Greiner, J.; Schady, P.; Rau, A.; Klose, S.; Kruhler, T.; Afonso, P. M. J.; Updike, A. C.; Nardini, M.; Filgas, R.;

GRB 050117: Simultaneous Gamma-ray and X-ray Observations with the Swift Satellite

NASA Technical Reports Server (NTRS)

Hill, J. E.; Morris, D. C.; Sakamoto, T.; Sato, G.; Burrows, D. N.; Angelini, L.; Pagani, C.; Moretti, A.; Abbey, A. F.; Barthelmy, S.

2005-01-01

The Swift Gamma-Ray Burst Explorer performed its first autonomous, X-ray follow-up to a newly detected GRB on 2005 January 17, within 193 seconds of the burst trigger by the Swift Burst Alert Telescope. While the burst was still in progress, the X-ray Telescope obtained a position and an image for an un-catalogued X-ray source; simultaneous with the gamma-ray observation. The XRT observed flux during the prompt emission was 1.1 x 10(exp -8) ergs/sq cm/s in the 0.5-10 keV energy band. The emission in the X-ray band decreased by three orders of magnitude within 700 seconds, following the prompt emission. This is found to be consistent with the gamma-ray decay when extrapolated into the XRT energy band. During the following 6.3 hours, the XRT observed the afterglow in an automated sequence for an additional 947 seconds, until the burst became fully obscured by the Earth limb. A faint, extremely slowly decaying afterglow, alpha=-0.21, was detected. Finally, a break in the lightcurve occurred and the flux decayed with alpha<-1.2. The X-ray position triggered many follow-up observations: no optical afterglow could be confirmed, although a candidate was identified 3 arcsecs from the XRT position.

A multiwavelength study of Swift GRB 060111B constraining the origin of its prompt optical emission

NASA Astrophysics Data System (ADS)

Stratta, G.; Pozanenko, A.; Atteia, J.-L.; Klotz, A.; Basa, S.; Gendre, B.; Verrecchia, F.; Boër, M.; Cutini, S.; Henze, M.; Holland, S.; Ibrahimov, M.; Ienna, F.; Khamitov, I.; Klose, S.; Rumyantsev, V.; Biryukov, V.; Sharapov, D.; Vachier, F.; Arnouts, S.; Perley, D. A.

2009-09-01

Context: The detection of bright optical emission measured with good temporal resolution during the prompt phase of GRB 060111Bmakes this GRB a rare event that is especially useful for constraining theories of the prompt emission. Aims: For this reason an extended multi-wavelength campaign was performed to further constrain the physical interpretation of the observations. Methods: In this work, we present the results obtained from our multi-wavelength campaign, as well as from the public Swift/BAT, XRT, and UVOT data. Results: We identified the host galaxy at R˜25 mag from deep R-band exposures taken 5 months after the trigger. Its featureless spectrum and brightness, as well as the non-detection of any associated supernova 16 days after the trigger, enabled us to constrain the distance scale of GRB 060111B11 within 0.4≤ z ≤3 in the most conservative case. The host galaxy spectral continuum is best fit with a redshift of z˜2, and other independent estimates converge to z˜1-2. From the analysis of the early afterglow SED, we find that non-negligible host galaxy dust extinction, in addition to the Galactic one, affects the observed flux in the optical regime. The extinction-corrected optical-to-gamma-ray SED during the prompt emission shows a flux density ratio Fγ/F_opt=10-2-10-4 with spectral index βγ,opt > βγ, strongly suggesting a separate origin of the optical and gamma-ray components. This result is supported by the lack of correlated behavior in the prompt emission light curves observed in the two energy domains. The temporal properties of the prompt optical emission observed during GRB 060111B11 and their similarities to other rapidly-observed events favor interpretation of this optical light as radiation from the reverse shock. Observations are in good agreement with theoretical expectations for a thick shell limit in slow cooling regime. The expected peak flux is consistent with the observed one corrected for the host extinction, likely indicating that the starting time of the TAROT observations is very near to or coincident with the peak time. The estimated fireball initial Lorentz factor is Γ≥260-360 at z=1-2, similar to the Lorentz factors obtained from other GRBs. GRB 060111B11 is a rare case of a GRB with both a bright, well-observed optical counterpart and a “canonical” early X-ray light curve, thus providing a good test case of the reverse shock emission mechanism in both energy ranges. Based on observations performed with: TAROT at the Calern observatory. The Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. CFHT, which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the CNRS of France, and the University of Hawaii. The 2.6 m Shajn telescope at the Crimean Astrophysical Observatory. Some of the data presented here were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation.

The Central Engine of GRB 130831A and the Energy Breakdown of a Relativistic Explosion

NASA Technical Reports Server (NTRS)

Pasquale, M. De; Oates, S. R.; Racusin, J. L.; Kann, D. A.; Zhang, B.; Pozanenko, A.; Volnova, A.A.; Trotter, A.; Frank, N.; Cucchiara, A.

2014-01-01

Gamma-ray bursts (GRBs) are the most luminous explosions in the Universe, yet the nature and physical properties of their energy sources are far from understood. Very important clues, however, can be inferred by studying the afterglows of these events. We present optical and X-ray observations of GRB 130831A obtained by Swift, Chandra, Skynet, Reionization And Transients Infra-Red camera, Maidanak, International Scientific Optical-Observation Network, Nordic Optical Telescope, Liverpool Telescope and Gran Telescopio Canarias. This burst shows a steep drop in the X-ray light curve at asymptotically equal to 10(exp 5) s after the trigger, with a power-law decay index of alpha that is approximately 6. Such a rare behaviour cannot be explained by the standard forward shock (FS) model and indicates that the emission, up to the fast decay at 10(exp 5) s, must be of internal origin, produced by a dissipation process within an ultrarelativistic outflow. We propose that the source of such an outflow, which must produce the X-ray flux for an asymptotically equal to 1 d in the cosmological rest frame, is a newly born magnetar or black hole. After the drop, the faint X-ray afterglow continues with a much shallower decay. The optical emission, on the other hand, shows no break across the X-ray steep decrease, and the late-time decays of both the X-ray and optical are consistent. Using both the X-ray and optical data, we show that the emission after an asymptotically equal to 10(exp 5) scan be explained well by the FS model. We model our data to derive the kinetic energy of the ejecta and thus measure the efficiency of the central engine of a GRB with emission of internal origin visible for a long time. Furthermore, we break down the energy budget of this GRB into the prompt emission, the late internal dissipation, the kinetic energy of the relativistic ejecta,and compare it with the energy of the associated supernova, SN 2013 fu.

VizieR Online Data Catalog: Cosmic evolution of long gamma-ray burst luminosity (Deng+, 2016)

NASA Astrophysics Data System (ADS)

Deng, C.-M.; Wang, X.-G.; Guo, B.-B.; Lu, R.-J.; Wang, Y.-Z.; Wei, J.-J.; Wu, X.-F.; Liang, E.-W.

2018-02-01

Our sample includes only the redshift-known long GRBs observed with Swift/BAT from 2005 January to 2015 April. Low-luminosity GRBs are excluded since they may belong to another distinct population (e.g., Chapman et al. 2007MNRAS.382L..21C; Liang et al. 2007ApJ...662.1111L; Lu et al. 2010ApJ...725.1965L). Although the durations of some GRBs, such as GRB 050724 and GRB 060614, are larger than 2s, we do not include them in our sample since they may be from merger of compact stars (Berger et al. 2005Natur.438..988B; Gehrels et al. 2006Natur.444.1044G; Zhang et al. 2007ApJ...655L..25Z, 2009ApJ...703.1696Z). The afterglow and host galaxy observations of the high-z SGRB GRB 090426 (T90=1.2s) show that it may be from the collapse of a massive star (Antonelli et al. 2009A&A...507L..45A; Xin et al. 2011MNRAS.410...27X). We thus include this GRB in our sample. We finally obtain a sample of 258 GRBs. They are reported in Table 1. (1 data file).

Heating of Dust in Gamma-Ray Burst Environments

NASA Astrophysics Data System (ADS)

Hackett, Brianne; Updike, A. C.; Hartmann, D. H.

2010-01-01

We report observations in the R-band of the afterglow of GRB 090618 with the SARA 0.9m telescope at Kitt Peak National Observatory. The lightcurve can be fit with a broken power law, with a possible jet break at t j ˜ 0.74 days. The foreground extinction to this burst is A R = 0.036 while the extinction in the host galaxy is undetermined. We also carry out a study of dust destruction due to heating by the prompt and early afterglow emission from the gamma-ray bursts. Dust can be destroyed to distances of several parsecs, so that the local environment of a GRB may not contribute significantly to the possible obscuration. While multiband photometry of GRB afterglows offers a powerful probe of dust evolution to large redshifts, the effects of the intense GRB radiation on dust in its vicinity must be taken into account. This project was funded by a partnership between the National Science Foundation (NSF AST-0552798), Research Experiences for Undergraduates (REU), and the Department of Defense (DoD) ASSURE (Awards to Stimulate and Support Undergraduate Research Experiences) programs. We thank S. Brittain, A. Colson, J. Lewis, and M. Kronberg for obtaining the CCD images with the SARA telescope. This project has also benefited from discussions with Renata Cumbee and Shanna Estes.

Probing Cosmic Dust of the Early Universe through High-Redshift Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Liang, S. L.; Li, Aigen

2009-01-01

We explore the extinction properties of the dust in the distant universe through the afterglows of high-redshifted gamma-ray bursts (GRBs) based on the "Drude" model which, unlike previous studies, does not require a prior assumption of template extinction laws. We select GRB 070802 at z ≈ 2.45 (which shows clear evidence for the 2175 Å extinction bump) and GRB 050904 at z ≈ 6.29, the second most distant GRB observed to date. We fit their afterglow spectra to determine the extinction of their host galaxies. We find that (1) their extinction curves differ substantially from that of the Milky Way and the Small and Large Magellanic Clouds (which were widely adopted as template extinction laws in the literature); (2) the 2175 Å extinction feature appears to be also present in GRB 050904 at z ≈ 6.29; and (3) there does not appear to be strong evidence for the dependence of dust extinction on redshifts. The inferred extinction curves are closely reproduced in terms of a mixture of amorphous silicate and graphite, both of which are expected supernova condensates and have been identified in primitive meteorites as presolar grains originating from supernovae (which are considered as the main source of dust at high-z).

A 'kilonova' associated with the short-duration γ-ray burst GRB 130603B.

PubMed

Tanvir, N R; Levan, A J; Fruchter, A S; Hjorth, J; Hounsell, R A; Wiersema, K; Tunnicliffe, R L

2013-08-29

Short-duration γ-ray bursts are intense flashes of cosmic γ-rays, lasting less than about two seconds, whose origin is unclear. The favoured hypothesis is that they are produced by a relativistic jet created by the merger of two compact stellar objects (specifically two neutron stars or a neutron star and a black hole). This is supported by indirect evidence such as the properties of their host galaxies, but unambiguous confirmation of the model is still lacking. Mergers of this kind are also expected to create significant quantities of neutron-rich radioactive species, whose decay should result in a faint transient, known as a 'kilonova', in the days following the burst. Indeed, it is speculated that this mechanism may be the predominant source of stable r-process elements in the Universe. Recent calculations suggest that much of the kilonova energy should appear in the near-infrared spectral range, because of the high optical opacity created by these heavy r-process elements. Here we report optical and near-infrared observations that provide strong evidence for such an event accompanying the short-duration γ-ray burst GRB 130603B. If this, the simplest interpretation of the data, is correct, then it confirms that compact-object mergers are the progenitors of short-duration γ-ray bursts and the sites of significant production of r-process elements. It also suggests that kilonovae offer an alternative, unbeamed electromagnetic signature of the most promising sources for direct detection of gravitational waves.

Study of GRBs Hosts Galaxies Vicinity Properties

NASA Astrophysics Data System (ADS)

Bernal, S.; Vasquez, N.; Hoyle, F.

2017-07-01

The study of GRBs host galaxies and its vicinity could provide constrains on the progenitor and an opportunity to use these violent explosions to characterize the nature of the highredshift universe. Studies of GRB host galaxies reveal a population of starforming galaxies with great diversity, spanning a wide range of masses, star formation rate, and redshifts. In order to study the galactic ambient of GRBs we used the S. Savaglio catalog from 2015 where 245 GRBs are listed with RA-Dec position and z. We choose 22 GRBs Hosts galaxies from Savaglio catalog and SDSS DR12, with z range 0

Distribution of compact object mergers around galaxies

NASA Astrophysics Data System (ADS)

Bulik, T.; Belczyński, K.; Zbijewski, W.

1999-09-01

Compact object mergers are one of the favoured models of gamma ray bursts (GRB). Using a binary population synthesis code we calculate properties of the population of compact object binaries; e.g. lifetimes and velocities. We then propagate them in galactic potentials and find their distribution in relation to the host.

VizieR Online Data Catalog: Gamma Ray Bursts detected by Swift (2004-2015) (Buchner+, 2017)

NASA Astrophysics Data System (ADS)

Buchner, J.; Schulze, S.; Bauer, F.

2016-04-01

Gamma Ray Bursts (GRB) typically show intrinsic LOS column densities of 1021-23cm2. We performed a thorough statistical analysis of all available X-ray spectra of Swift-detected GRBs. In the associated paper we use sub-samples to analyse the population properties of LGRB and concluded that the obscuration is due to large-scale gas inside the GRB host galaxy, due to the shape of the column density distribution and its correlation with host stellar mass. This catalogue presents X-ray spectral analysis of all Swift-detected GRBs. It includes information about the GRB (ID, Swift Trigger ID, duration, RA/Dec in J2000, galactic coordinates, Milky Way column density). Those properties are taken from the http://www.swift.ac.uk/ and http://gcn.gsfc.nasa.gov/ websites. We removed prompt emission and flares, leaving only a certain time interval for spectral extraction. We use two models to analyse X-ray spectra: TBABS and SPHERE. Both include updated abundances and cross-sections as compared to previous works. The latter includes the effects of Compton-scattering and FeKa fluorescence relevant at high column densities. Columns list the posterior mean, standard deviation, 10% and 90% quantiles. Note that the column densities are converted to hydrogen assuming local ISM abundances, but are derived primarily from photo-electric absorption of e.g. Fe and O, and therefore primarily measure metal gas. (2 data files).

Unraveling the Origin of Short Gamma-ray Bursts

NASA Technical Reports Server (NTRS)

Barthelmy, S. D.; Chincarini, G.; Burrows, D. N.; Gehrels, N.; Covino, S.; Moretti, A.; Romano, P.; OBrien, P. T.; Sarazin, C. L.; Kouveliotou, C.

2005-01-01

The origin of the short (<2 s) class of gamma-ray bursts (GRBs) is finally becoming clear after decades of search. The first one localized to a few arcseconds accuracy, GRB 050509B, was found to have a highly probable association with a nearby (z = 0.225) elliptical galaxy. A second one with arcsecond localization, GRB 050709, was also associated with a low redshift (z = 0.16) galaxy. We report here the detection of short GRB 050724 with remarkable properties; in particular, it has low energy gamma-ray emission that lasts for 100 s after the main short pulse, strong early X-ray afterglow, and an unusual lightcurve that rebrightens at 3x10(exp 4) s. A position on the sky accurate to 9 arcsec was determined and provided as a GCN alert to ground-based telescopes within 80 s. A subsequent high-resolution X-ray image provided a sub-arcsec position coincident with ground-based optical and radio observations of the afterglow. Like GRB 050509B, this burst is located off-center in an elliptical galaxy. The energy output of the GRB at the host distance of z = 0.258 is 2-3 orders of magnitude less than for long bursts. The low level of star formation in such galaxies is strong evidence against a collapsar or hypernova origin like that associated with long GRBs. Based on these new data, it is highly probable that short GRBs are produced by the coalescence of orbiting neutron stars (NSs) or black holes (BHs), with some evidence for a NS-BH merger in this burst.

GRB060218 as a Tidal Disruption of a White Dwarf by an Intermediate-mass Black Hole

NASA Astrophysics Data System (ADS)

Shcherbakov, Roman V.; Pe'er, Asaf; Reynolds, Christopher S.; Haas, Roland; Bode, Tanja; Laguna, Pablo

2013-06-01

The highly unusual pair of a gamma-ray burst (GRB) GRB060218 and an associated supernova, SN2006aj, has puzzled theorists for years. A supernova shock breakout and a jet from a newborn stellar mass compact object have been proposed to explain this pair's multiwavelength signature. Alternatively, we propose that the source is naturally explained by another channel: the tidal disruption of a white dwarf (WD) by an intermediate-mass black hole (IMBH). This tidal disruption is accompanied by a tidal pinching, which leads to the ignition of a WD and a supernova. Some debris falls back onto the IMBH, forms a disk, which quickly amplifies the magnetic field, and launches a jet. We successfully fit soft X-ray spectra with the Comptonized blackbody emission from a jet photosphere. The optical/UV emission is consistent with self-absorbed synchrotron emission from the expanding jet front. The temporal dependence of the accretion rate \\dot{M}(t) in a tidal disruption provides a good fit to the soft X-ray light curve. The IMBH mass is found to be about 104 M ⊙ in three independent estimates: (1) fitting the tidal disruption \\dot{M}(t) to the soft X-ray light curve, (2) computing the jet base radius in a jet photospheric emission model, and (3) inferring the mass of the central black hole based on the host dwarf galaxy's stellar mass. The position of the supernova is consistent with the center of the host galaxy, while the low supernova ejecta mass is consistent with that of a WD. The high expected rate of tidal disruptions in dwarf galaxies is consistent with one source observed by the Swift satellite over several years at a distance of 150 Mpc measured for GRB060218. Encounters with WDs provide much fuel for the growth of IMBHs.

Exploring Damped Ly Alpha System Host Galaxies Using Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Toy, Vicki L.; Cucchiara, Antonino; Veilleux, Sylvain; Fumagalli, Michele; Rafelski, Marc; Rahmati, Alireza; Cenko, S. Bradley; Capone, John I.; Pasham, Dheeraj R.

2016-01-01

We present a sample of 45 Damped Ly-Alpha system [DLA; H I-N is greater than or equal to 2 x 10(exp. 20) cm(exp. -2)] counterparts (33 detections, 12 upper limits) which host gamma-ray bursts (GRB-DLAs) in order to investigate star formation and metallicity within galaxies hosting DLAs. Our sample spans z is approx. 2 - 6 and is nearly three times larger than any previously detected DLA counterparts survey based on quasar line-of-sight searches (QSO-DLAs). We report star formation rates (SFRs) from rest-frame UV photometry and spectral energy distribution modeling. We find that DLA counterpart SFRs are not correlated with either redshift or H I column density. Thanks to the combination of Hubble Space Telescope and ground-based observations, we also investigate DLA host star formation efficiency. Our GRB-DLA counterpart sample spans both higher efficiency and low efficiency star formation regions compared to the local Kennicutt-Schmidt relation, local star formation laws, and z is approximately 3 cosmological simulations. We also compare the depletion times of our DLA hosts sample to other objects in the local universe; our sample appears to deviate from the star formation efficiencies measured in local spiral and dwarf galaxies. Furthermore, we find similar efficiencies as local inner disks, SMC, and Lyman-break galaxy outskirts. Finally, our enrichment time measurements show a spread of systems with under- and over-abundance of metals, which may suggest that these systems had episodic star formation and a metal enrichment/depletion as a result of strong stellar feedback and/or metal inflow/outflow.

A short gamma-ray burst apparently associated with an elliptical galaxy at redshift z = 0.225.

PubMed

Gehrels, N; Sarazin, C L; O'Brien, P T; Zhang, B; Barbier, L; Barthelmy, S D; Blustin, A; Burrows, D N; Cannizzo, J; Cummings, J R; Goad, M; Holland, S T; Hurkett, C P; Kennea, J A; Levan, A; Markwardt, C B; Mason, K O; Meszaros, P; Page, M; Palmer, D M; Rol, E; Sakamoto, T; Willingale, R; Angelini, L; Beardmore, A; Boyd, P T; Breeveld, A; Campana, S; Chester, M M; Chincarini, G; Cominsky, L R; Cusumano, G; de Pasquale, M; Fenimore, E E; Giommi, P; Gronwall, C; Grupe, D; Hill, J E; Hinshaw, D; Hjorth, J; Hullinger, D; Hurley, K C; Klose, S; Kobayashi, S; Kouveliotou, C; Krimm, H A; Mangano, V; Marshall, F E; McGowan, K; Moretti, A; Mushotzky, R F; Nakazawa, K; Norris, J P; Nousek, J A; Osborne, J P; Page, K; Parsons, A M; Patel, S; Perri, M; Poole, T; Romano, P; Roming, P W A; Rosen, S; Sato, G; Schady, P; Smale, A P; Sollerman, J; Starling, R; Still, M; Suzuki, M; Tagliaferri, G; Takahashi, T; Tashiro, M; Tueller, J; Wells, A A; White, N E; Wijers, R A M J

2005-10-06

Gamma-ray bursts (GRBs) come in two classes: long (> 2 s), soft-spectrum bursts and short, hard events. Most progress has been made on understanding the long GRBs, which are typically observed at high redshift (z approximately 1) and found in subluminous star-forming host galaxies. They are likely to be produced in core-collapse explosions of massive stars. In contrast, no short GRB had been accurately (< 10'') and rapidly (minutes) located. Here we report the detection of the X-ray afterglow from--and the localization of--the short burst GRB 050509B. Its position on the sky is near a luminous, non-star-forming elliptical galaxy at a redshift of 0.225, which is the location one would expect if the origin of this GRB is through the merger of neutron-star or black-hole binaries. The X-ray afterglow was weak and faded below the detection limit within a few hours; no optical afterglow was detected to stringent limits, explaining the past difficulty in localizing short GRBs.

Gamma-Ray Bursts and Cosmology

NASA Technical Reports Server (NTRS)

Norris, Jay P.

2003-01-01

The unrivalled, extreme luminosities of gamma-ray bursts (GRBs) make them the favored beacons for sampling the high redshift Universe. To employ GRBs to study the cosmic terrain -- e.g., star and galaxy formation history -- GRB luminosities must be calibrated, and the luminosity function versus redshift must be measured or inferred. Several nascent relationships between gamma-ray temporal or spectral indicators and luminosity or total energy have been reported. These measures promise to further our understanding of GRBs once the connections between the luminosity indicators and GRB jets and emission mechanisms are better elucidated. The current distribution of 33 redshifts determined from host galaxies and afterglows peaks near z $\\sim$ 1, whereas for the full BATSE sample of long bursts, the lag-luminosity relation predicts a broad peak z $\\sim$ 1--4 with a tail to z $\\sim$ 20, in rough agreement with theoretical models based on star formation considerations. For some GRB subclasses and apparently related phenomena -- short bursts, long-lag bursts, and X-ray flashes -- the present information on their redshift distributions is sparse or entirely lacking, and progress is expected in Swift era when prompt alerts become numerous.

THE LOCATIONS OF SHORT GAMMA-RAY BURSTS AS EVIDENCE FOR COMPACT OBJECT BINARY PROGENITORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fong, W.; Berger, E.

2013-10-10

We present a detailed investigation of Hubble Space Telescope rest-frame UV/optical observations of 22 short gamma-ray burst (GRB) host galaxies and sub-galactic environments. Utilizing the high angular resolution and depth of HST we characterize the host galaxy morphologies, measure precise projected physical and host-normalized offsets between the bursts and host centers, and calculate the locations of the bursts with respect to their host light distributions (rest-frame UV and optical). We calculate a median short GRB projected physical offset of 4.5 kpc, about 3.5 times larger than that for long GRBs, and find that ≈25% of short GRBs have offsets ofmore » ∼> 10 kpc. When compared to their host sizes, the median offset is 1.5 half-light radii (r{sub e} ), about 1.5 times larger than the values for long GRBs, core-collapse supernovae, and Type Ia supernovae. In addition, ≈20% of short GRBs having offsets of ∼> 5r{sub e} , and only ≈25% are located within 1r{sub e} . We further find that short GRBs severely under-represent their hosts' rest-frame optical and UV light, with ≈30%-45% of the bursts located in regions of their host galaxies that have no detectable stellar light, and ≈55% in the regions with no UV light. Therefore, short GRBs do not occur in regions of star formation or even stellar mass. This demonstrates that the progenitor systems of short GRBs must migrate from their birth sites to their eventual explosion sites, a signature of kicks in compact object binary systems. Utilizing the full sample of offsets, we estimate natal kick velocities of ≈20-140 km s{sup –1}. These independent lines of evidence provide the strongest support to date that short GRBs result from the merger of compact object binaries (NS-NS/NS-BH)« less

MASTER Optical Detection of the First LIGO/Virgo Neutron Star Binary Merger GW170817

NASA Astrophysics Data System (ADS)

Lipunov, V. M.; Gorbovskoy, E.; Kornilov, V. G.; . Tyurina, N.; Balanutsa, P.; Kuznetsov, A.; Vlasenko, D.; Kuvshinov, D.; Gorbunov, I.; Buckley, D. A. H.; Krylov, A. V.; Podesta, R.; Lopez, C.; Podesta, F.; Levato, H.; Saffe, C.; Mallamachi, C.; Potter, S.; Budnev, N. M.; Gress, O.; Ishmuhametova, Yu.; Vladimirov, V.; Zimnukhov, D.; Yurkov, V.; Sergienko, Yu.; Gabovich, A.; Rebolo, R.; Serra-Ricart, M.; Israelyan, G.; Chazov, V.; Wang, Xiaofeng; Tlatov, A.; Panchenko, M. I.

2017-11-01

Following the discovery of the gravitational-wave source GW170817 by three Laser Interferometer Gravitational-wave Observatory (LIGO)/Virgo antennae (Abbott et al., 2017a), the MASTER Global Robotic Net telescopes obtained the first image of the NGC 4993 host galaxy. An optical transient, MASTER OTJ130948.10-232253.3/SSS17a was later found, which appears to be a kilonova resulting from the merger of two neutron stars (NSs). Here we describe this independent detection and photometry of the kilonova made in white light, and in B, V, and R filters. We note that the luminosity of this kilonova in NGC 4993 is very close to those measured for other kilonovae possibly associated with gamma-ray burst (GRB) 130603 and GRB 080503.

Understanding Grb Physics With Multi-Wavelength Data

NASA Astrophysics Data System (ADS)

Zhang, Bing

The study of Gamma-ray bursts (GRBs) has entered a full multi-wavelength era. A rich trove of data from NASA GRB missions and ground-based follow up observations have been collected. Careful data mining with well-defined scientific objectives holds the key to address open questions in GRB physics, such as jet composition, radiation mechanism, progenitor and central engine physics. We propose to perform data analyses in the following three directions. 1. The time resolved GRB spectra have a dominant component that can be fit with a phenomenological ``Band'' function. The physical meaning of this function remains unclear. Recently we made a breakthrough in theoretical modeling, and showed that fast-cooling synchrotron radiation of electrons in a decreasing magnetic field can mimic the Band function in detector's bandpass, but differs from Band function slightly. We propose to apply this physically-motivated model to systematically fit the GRB prompt emission data collected by Fermi GBM and LAT, and test whether the dominant GRB emission mechanism is fast cooling synchrotron radiation. We will also fit time-dependent spectra with a time-dependent model to investigate whether a quasi- thermal "photosphere'' emission component is indeed needed to fit the observed spectra. This would shed light onto the unknown composition of GRB jets. By fitting the time resolved spectra, we will also constrain important physical parameters of GRB prompt emission, such as the emission site of GRBs, the strength of magnetic fields, as well as their evolution with radius. 2. Recent GRB multi-wavelength observations suggest that it is not straightforward to define the physical category of a GRB based on the traditional classification in the "duration''-"hardness'' domain. Some long-duration GRBs may not have a massive star origin, while some short-duration GRBs may instead have a massive star origin. We propose to systematically study the gamma-ray Swift/BAT, Fermi/GBM- LAT), X-ray (Swift/XRT, Chandra), and optical (ground-based and HST) properties of all short GRBs, and apply multi-wavelength observational criteria to constrain the possible progenitor(s) of them. 3. The GRB central engine is still not identified. Growing observational data and theoretical modeling suggest that at least some GRBs may host a magnetar (in contrast to a hyper-accreting black hole) central engine. We propose to carry out a statistical study of the prompt emission and afterglow properties of GRBs that show possible evidence of magnetar behavior and compare their properties with those that do not show such evidence. We will define three samples: a gold sample that show a steady X-ray emission followed by a rapid decline, which are likely powered by internal dissipation of a magnetar wind, a silver sample showing a shallow decay segment followed by a normal decay, which can be interpreted as external shock emission with a magnetar continuous energy injection into the blastwave, and a sample that includes other GRBs that do not show any evidence of magnetar. We will compare various observational properties (e.g. isotropic energy/luminosity, jet-corrected energy/luminosity, jet opening angle, peak energy) of these samples and investigate whether there are noticeable differences among these samples. The results would shed light onto the difficult problem of GRB central engine, addressing whether different engines work in GRBs, and if so, what difference. The program conforms to NASA's Strategic Plan, and will make use of the public archival data of many NASA missions, including Fermi, Swift, HST, and Chandra.

VLT/X-Shooter spectroscopy of the afterglow of the Swift GRB 130606A. Chemical abundances and reionisation at z ~ 6

NASA Astrophysics Data System (ADS)

Hartoog, O. E.; Malesani, D.; Fynbo, J. P. U.; Goto, T.; Krühler, T.; Vreeswijk, P. M.; De Cia, A.; Xu, D.; Møller, P.; Covino, S.; D'Elia, V.; Flores, H.; Goldoni, P.; Hjorth, J.; Jakobsson, P.; Krogager, J.-K.; Kaper, L.; Ledoux, C.; Levan, A. J.; Milvang-Jensen, B.; Sollerman, J.; Sparre, M.; Tagliaferri, G.; Tanvir, N. R.; de Ugarte Postigo, A.; Vergani, S. D.; Wiersema, K.; Datson, J.; Salinas, R.; Mikkelsen, K.; Aghanim, N.

2015-08-01

Context. The reionisation of the Universe is a process that is thought to have ended around z ~ 6, as inferred from spectroscopy of distant bright background sources, such as quasars (QSO) and gamma-ray burst (GRB) afterglows. Furthermore, spectroscopy of a GRB afterglow provides insight in its host galaxy, which is often too dim and distant to study otherwise. Aims: For the Swift GRB 130606A at z = 5.913 we have obtained a high S/N spectrum covering the full optical and near-IR wavelength region at intermediate spectral resolution with VLT/X-Shooter. We aim to measure the degree of ionisation of the intergalactic medium (IGM) between z = 5.02-5.84 and to study the chemical abundance pattern and dust content of its host galaxy. Methods: We estimated the UV continuum of the GRB afterglow using a power-law extrapolation, then measured the flux decrement due to absorption at Lyα,β, and γ wavelength regions. Furthermore, we fitted the shape of the red damping wing of Lyα. The hydrogen and metal absorption lines formed in the host galaxy were fitted with Voigt profiles to obtain column densities. We investigated whether ionisation corrections needed to be applied. Results: Our measurements of the Lyα-forest optical depth are consistent with previous measurements of QSOs, but have a much smaller uncertainty. The analysis of the red damping wing yields a neutral fraction xH i< 0.05 (3σ). We obtain column density measurements of H, Al, Si, and Fe; for C, O, S and Ni we obtain limits. The ionisation due to the GRB is estimated to be negligible (corrections <0.03 dex), but larger corrections may apply due to the pre-existing radiation field (up to 0.4 dex based on sub-DLA studies). Assuming that [ Si/Fe ] = +0.79 ± 0.13 is due to dust depletion, the dust-to-metal ratio is similar to the Galactic value. Conclusions: Our measurements confirm that the Universe is already predominantly ionised over the redshift range probed in this work, but was slightly more neutral at z> 5.6. GRBs are useful probes of the ionisation state of the IGM in the early Universe, but because of internal scatter we need a larger statistical sample to draw robust conclusions. The high [Si/Fe] in the host can be due to dust depletion, α-element enhancement, or a combination of both. The very high value of [ Al/Fe ] = 2.40 ± 0.78 might be due to a proton capture process and is probably connected to the stellar population history. We estimate the host metallicity to be -1.7 < [ M/H ] < -0.9 (2%-13% of solar). Based on observations carried out under prog. ID 091.C-0934(C) with the X-Shooter spectrograph installed at the Cassegrain focus of the Very Large Telescope (VLT), Unit 2 - Kueyen, operated by the European Southern Observatory (ESO) on Cerro Paranal, Chile. Partly based on observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Partly based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, under programme A26TAC_63.Appendix A is available in electronic form at http://www.aanda.orgThe reduced spectrum (FITS file) is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/580/A139

Go Long, Go Deep: Finding Optical Jet Breaks for Swift-Era GRBs with the LBT

NASA Astrophysics Data System (ADS)

Dai, X.; Garnavich, P. M.; Prieto, J. L.; Stanek, K. Z.; Kochanek, C. S.; Bechtold, J.; Bouche, N.; Buschkamp, P.; Diolaiti, E.; Fan, X.; Giallongo, E.; Gredel, R.; Hill, J. M.; Jiang, L.; McClelland, C.; Milne, P.; Pedichini, F.; Pogge, R. W.; Ragazzoni, R.; Rhoads, J.; Smareglia, R.; Thompson, D.; Wagner, R. M.

2008-08-01

Using the 8.4 m Large Binocular Telescope, we observed six GRB afterglows from 2.8 hr to 30.8 days after the burst triggers to systematically probe the late-time behaviors of afterglows including jet breaks, flares, and supernova bumps. We detected five afterglows with Sloan r' magnitudes ranging from 23.0 to 26.3 mag. The depth of our observations allows us to extend the temporal baseline for measuring jet breaks by another decade in timescale. We detected two jet breaks and a third candidate, all of which are not detectable without deep, late-time optical observations. In the other three cases, we do not detect the jet breaks either because of contamination from the host galaxy light, the presence of a supernova bump, or the intrinsic faintness of the optical afterglow. This suggests that the basic picture that GRBs are collimated is still valid and that the apparent lack of Swift jet breaks is due to poorly sampled afterglow light curves, particularly at late times. Based on data acquired using the Large Binocular Telescope (LBT). The LBT is an international collaboration among institutions in the United States, Italy, and Germany. LBT Corporation partners are the University of Arizona on behalf of the Arizona university system; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max Planck Society, the Astrophysical Institute Potsdam, and Heidelberg University; the Ohio State University; and the Research Corporation, on behalf of the University of Notre Dame, the University of Minnesota, and the University of Virginia.

Swift J2058.4+0516: Discovery of a Possible Second Relativistic Tidal Disruption Flare

NASA Technical Reports Server (NTRS)

Cenko, S. Bradely; Krimm, Hans A.; Horesh, Assaf; Rau, Arne; Frail, Dale A.; Kennea, Jamie A.; Levan, Andrew J.; Holland, Stephen T.; Butler, Nathaniel R.; Quimby, Robert M.;

The Swift/Fermi GRB 080928 from 1 eV to 150 keV

NASA Technical Reports Server (NTRS)

Sonbas, Eda; Rossi, A.; Schulze, S.; Klose, S.; Kann, D. A.; Ferrero, P.; NicuesaGuelbenzu, A.; Rau, A.; Kruehler, T.; Greiner, J.;

SN 2013dx associated with GRB 130702A: a detailed photometric and spectroscopic monitoring and a study of the environment

NASA Astrophysics Data System (ADS)

D'Elia, Valerio

2015-08-01

Long duration gamma-ray bursts (GRBs) and broad-line, type Ic supernovae (SNe) are strongly connected. We aim at characterizing SN 2013dx, associated with GRB 130702A, through sensitive and extensive ground-based observational campaigns in the optical-IR band.We monitored the field of the Swift GRB 130702A (redshift z = 0.145) using the 8.2-m VLT, the 3.6-m TNG and the 0.6-m REM telescopes during the time interval between 4 and 40 days after the burst. Photometric and spectroscopic observations revealed the presence of the associated Type Ic SN 2013dx. Our multi-band photometry allowed the construction of a bolometric light curve.The bolometric light curve of SN 2013dx resembles that of 2003dh (associated with GRB 030329), but is ~ 10% faster and ~25% dimmer. From this we infer a synthesized 56Ni mass of ~0.3 solar masses. The multi-epoch optical spectroscopy shows that the SN 2013dx behavior is best matched by SN 1998bw, among the other well-known low-z SNe associated with GRBs and XRFs, and by SN 2010ah, an energetic Type Ic SN not associated with any GRB. The photospheric velocity of the ejected material declines from ~ 2.7 X10^4 km/s at 8 rest frame days from the explosion, to ~3.5X103 km/s at 40 days. These values are extremely close to those of SN1998bw and 2010ah. We deduce for SN 2013dx a kinetic energy of (32 +/- 9)X10^51 erg, and an ejected mass of 7 +/- 1 solar masses. This suggests that the progenitor of SN2013dx had a mass of ~25 solar masses, i.e., 15-20% less massive than that of SN 1998bw.Finally, we perfom a study of the SN 2013dx environment, through spectroscopy of the closeby galaxies. 9 out of the 14 inspected galaxies lie within 0.03 in redshift from z=0.145, indicating that the host of GRB 130702A/SN 2013dx belongs to a group of galaxies, an unprecedented finding for a GRB-associated SN and, to our knowledge, for long GRBs in general.

GRBs: The Most Distant Signposts in our Universe

NASA Technical Reports Server (NTRS)

Kouveliotou, Chryssa

2007-01-01

Gamma-Ray Bursts (GRBs) are the most powerful photon sources in the Universe, rivaled only by supernovae in the magnitude of their energy release. In 1997 GRB were found to originate in host galaxies at cosmological distances, revealing the total energy of their explosions to be an astounding approx.10(exp 52) - 10(exp 53)ergs. GRB durations span over five orders of magnitude, ranging from milliseconds to thousands of seconds. The underlying sources of the energy release remain, however, unknown. Leading candidates are mergers, either of two neutron stars or of a black hole and a neutron star, and core collapses of very massive stars, called "collapsars". To date the furthest GRB galaxy has been found at a cosmological redshift of 6.29, very close to the most distant quasar (at z=6.4). Since the Swift satellite continues to observe these phenomena at a rate of approx.120 per year, and with the upcoming launch of GLAST with two burst instruments on board, we will be able to use GRBs as beacons to probe very high redshifts. Thus bursts found at 6

Dust reddening and extinction curves toward gamma-ray bursts at z > 4

NASA Astrophysics Data System (ADS)

Bolmer, J.; Greiner, J.; Krühler, T.; Schady, P.; Ledoux, C.; Tanvir, N. R.; Levan, A. J.

2018-01-01

Context. Dust is known to be produced in the envelopes of asymptotic giant branch (AGB) stars, the expanded shells of supernova (SN) remnants, and in situ grain growth within the interstellar medium (ISM), although the corresponding efficiency of each of these dust formation mechanisms at different redshifts remains a topic of debate. During the first Gyr after the Big Bang, it is widely believed that there was not enough time to form AGB stars in high numbers, hence the dust at this epoch is expected to be purely from SNe or subsequent grain growth in the ISM. The time period corresponding to z 5-6 is thus expected to display the transition from SN-only dust to a mixture of both formation channels as is generally recognized at present. Aims: Here we aim to use afterglow observations of gamma-ray bursts (GRBs) at redshifts larger than z > 4 to derive host galaxy dust column densities along their line of sight and to test if a SN-type dust extinction curve is required for some of the bursts. Methods: We performed GRB afterglow observations with the seven-channel Gamma-Ray Optical and Near-infrared Detector (GROND) at the 2.2 m MPI telescope in La Silla, Chile (ESO), and we combined these observations with quasi-simultaneous data gathered with the XRT telescope on board the Swift satellite. Results: We increase the number of measured AV values for GRBs at z > 4 by a factor of 2-3 and find that, in contrast to samples at mostly lower redshift, all of the GRB afterglows have a visual extinction of AV < 0.5 mag. Analysis of the GROND detection thresholds and results from a Monte Carlo simulation show that although we partly suffer from an observational bias against highly extinguished sight-lines, GRB host galaxies at 4 < z < 6 seem to contain on average less dust than at z 2. Additionally, we find that all of the GRBs can be modeled with locally measured extinction curves and that the SN-like dust extinction curve, as previously found toward GRB 071025, provides a better fit for only two of the afterglow SEDs. However, because of the lack of highly extinguished sight lines and the limited wavelength coverage we cannot distinguish between the different scenarios. For the first time we also report a photometric redshift of zphot = 7.88-0.94+0.75 for GRB 100905A, making it one of the most distant GRBs known to date.

Covariance of lucky images: performance analysis

NASA Astrophysics Data System (ADS)

Cagigal, Manuel P.; Valle, Pedro J.; Cagigas, Miguel A.; Villó-Pérez, Isidro; Colodro-Conde, Carlos; Ginski, C.; Mugrauer, M.; Seeliger, M.

2017-01-01

The covariance of ground-based lucky images is a robust and easy-to-use algorithm that allows us to detect faint companions surrounding a host star. In this paper, we analyse the relevance of the number of processed frames, the frames' quality, the atmosphere conditions and the detection noise on the companion detectability. This analysis has been carried out using both experimental and computer-simulated imaging data. Although the technique allows us the detection of faint companions, the camera detection noise and the use of a limited number of frames reduce the minimum detectable companion intensity to around 1000 times fainter than that of the host star when placed at an angular distance corresponding to the few first Airy rings. The reachable contrast could be even larger when detecting companions with the assistance of an adaptive optics system.

Lyman-α emitters gone missing: the different evolution of the bright and faint populations

NASA Astrophysics Data System (ADS)

Weinberger, Lewis H.; Kulkarni, Girish; Haehnelt, Martin G.; Choudhury, Tirthankar Roy

2018-06-01

We model the transmission of the Lyman-α line through the circum- and intergalactic media around dark matter haloes expected to host Lyman-alpha emitters (LAEs) at z ≥ 5.7, using the high-dynamic-range Sherwood simulations. We find very different CGM environments around more massive haloes (˜1011M⊙) compared to less massive haloes (˜109M⊙) at these redshifts, which can contribute to a different evolution of the Lyα transmission from LAEs within these haloes. Additionally we confirm that part of the differential evolution could result from bright LAEs being more likely to reside in larger ionized regions. We conclude that a combination of the CGM environment and the IGM ionization structure is likely to be responsible for the differential evolution of the bright and faint ends of the LAE luminosity function at z ≥ 6. More generally, we confirm the suggestion that the self-shielded neutral gas in the outskirts of the host halo can strongly attenuate the Lyα emission from high redshift galaxies. We find that this has a stronger effect on the more massive haloes hosting brighter LAEs. The faint-end of the LAE luminosity function is thus a more reliable probe of the average ionization state of the IGM. Comparing our model for LAEs with a range of observational data we find that the favoured reionization histories are our previously advocated `Late' and `Very Late' reionization histories, in which reionization finishes rather rapidly at around z ≃ 6.

The afterglow and elliptical host galaxy of the short gamma-ray burst GRB 050724.

PubMed

Berger, E; Price, P A; Cenko, S B; Gal-Yam, A; Soderberg, A M; Kasliwal, M; Leonard, D C; Cameron, P B; Frail, D A; Kulkarni, S R; Murphy, D C; Krzeminski, W; Piran, T; Lee, B L; Roth, K C; Moon, D-S; Fox, D B; Harrison, F A; Persson, S E; Schmidt, B P; Penprase, B E; Rich, J; Peterson, B A; Cowie, L L

2005-12-15

Despite a rich phenomenology, gamma-ray bursts (GRBs) are divided into two classes based on their duration and spectral hardness--the long-soft and the short-hard bursts. The discovery of afterglow emission from long GRBs was a watershed event, pinpointing their origin to star-forming galaxies, and hence the death of massive stars, and indicating an energy release of about 10(51) erg. While theoretical arguments suggest that short GRBs are produced in the coalescence of binary compact objects (neutron stars or black holes), the progenitors, energetics and environments of these events remain elusive despite recent localizations. Here we report the discovery of the first radio afterglow from the short burst GRB 050724, which unambiguously associates it with an elliptical galaxy at a redshift z = 0.257. We show that the burst is powered by the same relativistic fireball mechanism as long GRBs, with the ejecta possibly collimated in jets, but that the total energy release is 10-1,000 times smaller. More importantly, the nature of the host galaxy demonstrates that short GRBs arise from an old (> 1 Gyr) stellar population, strengthening earlier suggestions and providing support for coalescing compact object binaries as the progenitors.

Evidence for Dynamically Driven Formation of the GW170817 Neutron Star Binary in NGC 4993

NASA Astrophysics Data System (ADS)

Palmese, A.; Hartley, W.; Tarsitano, F.; Conselice, C.; Lahav, O.; Allam, S.; Annis, J.; Lin, H.; Soares-Santos, M.; Tucker, D.; Brout, D.; Banerji, M.; Bechtol, K.; Diehl, H. T.; Fruchter, A.; García-Bellido, J.; Herner, K.; Levan, A. J.; Li, T. S.; Lidman, C.; Misra, K.; Sako, M.; Scolnic, D.; Smith, M.; Abbott, T. M. C.; Abdalla, F. B.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Castander, F. J.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; Davis, C.; DePoy, D. L.; Desai, S.; Dietrich, J. P.; Doel, P.; Drlica-Wagner, A.; Eifler, T. F.; Evrard, A. E.; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gerdes, D. W.; Giannantonio, T.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; Honscheid, K.; Jain, B.; James, D. J.; Jeltema, T.; Johnson, M. W. G.; Johnson, M. D.; Krause, E.; Kron, R.; Kuehn, K.; Kuhlmann, S.; Kuropatkin, N.; Lima, M.; Maia, M. A. G.; March, M.; Marshall, J. L.; McMahon, R. G.; Menanteau, F.; Miller, C. J.; Miquel, R.; Neilsen, E.; Ogando, R. L. C.; Plazas, A. A.; Reil, K.; Romer, A. K.; Sanchez, E.; Schindler, R.; Smith, R. C.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Thomas, R. C.; Walker, A. R.; Weller, J.; Zhang, Y.; Zuntz, J.

2017-11-01

We present a study of NGC 4993, the host galaxy of the GW170817 gravitational-wave event, the GRB 170817A short gamma-ray burst (sGRB), and the AT 2017gfo kilonova. We use Dark Energy Camera imaging, AAT spectra, and publicly available data, relating our findings to binary neutron star (BNS) formation scenarios and merger delay timescales. NGC 4993 is a nearby early-type galaxy, with an I-band Sérsic index n = 4.0 and low asymmetry (A = 0.04 ± 0.01). These properties are unusual for sGRB hosts. However, NGC 4993 presents shell-like structures and dust lanes indicative of a recent galaxy merger, with the optical transient located close to a shell. We constrain the star formation history (SFH) of the galaxy assuming that the galaxy merger produced a star formation burst, but find little to no ongoing star formation in either spatially resolved broadband SED or spectral fitting. We use the best-fit SFH to estimate the BNS merger rate in this type of galaxy, as {R}{NSM}{gal}={5.7}-3.3+0.57× {10}-6{{yr}}-1. If star formation is the only considered BNS formation scenario, the expected number of BNS mergers from early-type galaxies detectable with LIGO during its first two observing seasons is {0.038}-0.022+0.004, as opposed to ˜0.5 from all galaxy types. Hypothesizing that the binary formed due to dynamical interactions during the galaxy merger, the subsequent time elapsed can constrain the delay time of the BNS coalescence. By using velocity dispersion estimates and the position of the shells, we find that the galaxy merger occurred t mer ≲ 200 Myr prior to the BNS coalescence.

Evidence for Dynamically Driven Formation of the GW170817 Neutron Star Binary in NGC 4993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palmese, A.; Hartley, W.; Tarsitano, F.

Here, we present a study of NGC 4993, the host galaxy of the GW170817 gravitational-wave event, the GRB 170817A short gamma-ray burst (sGRB), and the AT 2017gfo kilonova. We use Dark Energy Camera imaging, AAT spectra, and publicly available data, relating our findings to binary neutron star (BNS) formation scenarios and merger delay timescales. NGC 4993 is a nearby early-type galaxy, with an i-band Sérsic index n = 4.0 and low asymmetry (A = 0.04 ± 0.01). These properties are unusual for sGRB hosts. However, NGC 4993 presents shell-like structures and dust lanes indicative of a recent galaxy merger, with the optical transient located close to a shell. We constrain the star formation history (SFH) of the galaxy assuming that the galaxy merger produced a star formation burst, but find little to no ongoing star formation in either spatially resolved broadband SED or spectral fitting. We use the best-fit SFH to estimate the BNS merger rate in this type of galaxy, asmore » $${R}_{\\mathrm{NSM}}^{\\mathrm{gal}}={5.7}_{-3.3}^{+0.57}\\times {10}^{-6}{\\mathrm{yr}}^{-1}$$. If star formation is the only considered BNS formation scenario, the expected number of BNS mergers from early-type galaxies detectable with LIGO during its first two observing seasons is $${0.038}_{-0.022}^{+0.004}$$, as opposed to ~0.5 from all galaxy types. Hypothesizing that the binary formed due to dynamical interactions during the galaxy merger, the subsequent time elapsed can constrain the delay time of the BNS coalescence. By using velocity dispersion estimates and the position of the shells, we find that the galaxy merger occurred t mer $$\\lesssim$$ 200 Myr prior to the BNS coalescence.« less

Evidence for Dynamically Driven Formation of the GW170817 Neutron Star Binary in NGC 4993

DOE PAGES

Palmese, A.; Hartley, W.; Tarsitano, F.; ...

2017-11-09

Here, we present a study of NGC 4993, the host galaxy of the GW170817 gravitational-wave event, the GRB 170817A short gamma-ray burst (sGRB), and the AT 2017gfo kilonova. We use Dark Energy Camera imaging, AAT spectra, and publicly available data, relating our findings to binary neutron star (BNS) formation scenarios and merger delay timescales. NGC 4993 is a nearby early-type galaxy, with an i-band Sérsic index n = 4.0 and low asymmetry (A = 0.04 ± 0.01). These properties are unusual for sGRB hosts. However, NGC 4993 presents shell-like structures and dust lanes indicative of a recent galaxy merger, with the optical transient located close to a shell. We constrain the star formation history (SFH) of the galaxy assuming that the galaxy merger produced a star formation burst, but find little to no ongoing star formation in either spatially resolved broadband SED or spectral fitting. We use the best-fit SFH to estimate the BNS merger rate in this type of galaxy, asmore » $${R}_{\\mathrm{NSM}}^{\\mathrm{gal}}={5.7}_{-3.3}^{+0.57}\\times {10}^{-6}{\\mathrm{yr}}^{-1}$$. If star formation is the only considered BNS formation scenario, the expected number of BNS mergers from early-type galaxies detectable with LIGO during its first two observing seasons is $${0.038}_{-0.022}^{+0.004}$$, as opposed to ~0.5 from all galaxy types. Hypothesizing that the binary formed due to dynamical interactions during the galaxy merger, the subsequent time elapsed can constrain the delay time of the BNS coalescence. By using velocity dispersion estimates and the position of the shells, we find that the galaxy merger occurred t mer $$\\lesssim$$ 200 Myr prior to the BNS coalescence.« less

Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.

PubMed

Hao, Jun; Ci, Xinpei; Xue, Hui; Wu, Rebecca; Dong, Xin; Choi, Stephen Yiu Chuen; He, Haiqing; Wang, Yu; Zhang, Fang; Qu, Sifeng; Zhang, Fan; Haegert, Anne M; Gout, Peter W; Zoubeidi, Amina; Collins, Colin; Gleave, Martin E; Lin, Dong; Wang, Yuzhuo

2018-06-01

Although androgen deprivation therapy is initially effective in controlling growth of hormone-naive prostate cancers (HNPCs) in patients, currently incurable castration-resistant prostate cancer (CRPC) inevitably develops. To identify CRPC driver genes that may provide new targets to enhance CRPC therapy. Patient-derived xenografts (PDXs) of HNPCs that develop CRPC following host castration were examined for changes in expression of genes at various time points after castration using transcriptome profiling analysis; particular attention was given to pre-CRPC changes in expression indicative of genes acting as potential CRPC drivers. The functionality of a potential CRPC driver was validated via its knockdown in cultured prostate cancer cells; its clinical relevance was established using data from prostate cancer patient databases. Eighty genes were found to be significantly upregulated at the CRPC stage, while seven of them also showed elevated expression prior to CRPC development. Among the latter, growth factor receptor bound protein 10 (GRB10) was the most significantly and consistently upregulated gene. Moreover, elevated GRB10 expression in clinical prostate cancer samples correlated with more aggressive tumor types and poorer patient treatment outcome. GRB10 knockdown markedly reduced prostate cancer cell proliferation and activity of AKT, a well-established CRPC mediator. A positive correlation between AKT activity and GRB10 expression was also found in clinical cohorts. GRB10 acts as a driver of CRPC and sensitizes androgen receptor pathway inhibitors, and hence GRB10 targeting provides a novel therapeutic strategy for the disease. Development of castration-resistant prostate cancer (CRPC) is a major problem in the management of the disease. Using state-of-the-art patient-derived hormone-naive prostate cancer xenograft models, we found and validated the growth factor receptor bound protein 10 gene as a driver of CRPC, indicating that it may be used as a new molecular target to enhance current CRPC therapy. Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Gamma-Ray Burst Host Galaxies Have "Normal" Luminosities.

PubMed

Schaefer

2000-04-10

The galactic environment of gamma-ray bursts can provide good evidence about the nature of the progenitor system, with two old arguments implying that the burst host galaxies are significantly subluminous. New data and new analysis have now reversed this picture: (1) Even though the first two known host galaxies are indeed greatly subluminous, the next eight hosts have absolute magnitudes typical for a population of field galaxies. A detailed analysis of the 16 known hosts (10 with redshifts) shows them to be consistent with a Schechter luminosity function with R*=-21.8+/-1.0, as expected for normal galaxies. (2) Bright bursts from the Interplanetary Network are typically 18 times brighter than the faint bursts with redshifts; however, the bright bursts do not have galaxies inside their error boxes to limits deeper than expected based on the luminosities for the two samples being identical. A new solution to this dilemma is that a broad burst luminosity function along with a burst number density varying as the star formation rate will require the average luminosity of the bright sample (>6x1058 photons s-1 or>1.7x1052 ergs s-1) to be much greater than the average luminosity of the faint sample ( approximately 1058 photons s-1 or approximately 3x1051 ergs s-1). This places the bright bursts at distances for which host galaxies with a normal luminosity will not violate the observed limits. In conclusion, all current evidence points to gamma-ray burst host galaxies being normal in luminosity.

How Special Is GRB 170817A?

NASA Astrophysics Data System (ADS)

Yue, Chuan; Hu, Qian; Zhang, Fu-Wen; Liang, Yun-Feng; Jin, Zhi-Ping; Zou, Yuan-Chuan; Fan, Yi-Zhong; Wei, Da-Ming

2018-01-01

GRB 170817A is the first short gamma-ray burst (GRB) with direct detection of the gravitational-wave radiation and also the spectroscopically identified macronova emission (i.e., AT 2017gfo). The prompt emission of this burst, however, is underluminous in comparison with the other short GRBs with known redshift. In this work, we examine whether GRB 170817A is indeed unique. We first show that GRB 130603B/macronova may be the on-axis “analogs” of GRB 170817A/AT 2017gfo, and the extremely dim but long-lasting afterglow emission of GRB 170817A may suggest a low number density (∼ {10}-5 {{cm}}-3) of its circumburst medium and a structured outflow. We then discuss whether GRB 070923, GRB 080121, GRB 090417A, GRB 111005A, and GRB 170817A form a new group of very nearby underluminous GRBs originated from neutron star mergers. If the short events GRB 070923, GRB 080121, and GRB 090417A are indeed at a redshift of ∼ 0.076, 0.046, 0.088, respectively, their isotropic energies of the prompt emission are ∼ {10}47 erg and thus comparable to the other two events. The non-detection of optical counterparts of GRB 070923, GRB 080121, GRB 090417A, and GRB 111005A, however, strongly suggests that the macronovae from neutron star mergers are significantly diverse in luminosities or, alternatively, there is another origin channel (for instance, the white dwarf and black hole mergers). We finally suggest that GW170817/GRB 170817A are likely not alone and similar events will be detected by the upgraded/upcoming gravitational-wave detectors and the electromagnetic monitors.

The Achromatic Light Curve of the Optical Afterglow of GRB 030226 at a Redshift of z Approximately 2

NASA Technical Reports Server (NTRS)

Klose, S.; Greiner, J.; Rau, A.; Henden, A. A.; Hartmann, D. H.; Zeh, A.; Masetti, N.; Guenther, E.; Stecklum, B.; Lindsay, K.

2003-01-01

Abstract. We report on optical and near-infrared (NIR) follow-up observations of the afterglow of GRB 030226, mainly performed with the telescopes at ESO La Silla and Paranal, with additional data obtained at other places. Our first observations started 0.2 days after the burst when the afterglow was at a magnitude of R approximately equal to 19 . One week later the magnitude of the afterglow had fallen to R=25, and at two weeks after the burst it could no longer be detected (R > 26). Our VLT blueband spectra show two absorption line systems at redshifts z = 1.962 +/- 0.001 and at z = 1.986 +/- 0.001, placing the redshift of the burster close to 2. Within our measurement errors no evidence for variations in the line strengths has been found between 0.2 and 1.2 days after the burst. An overabundance of alpha-group elements might indicate that the burst occurred in a chemically young interstellar region shaped by the nucleosynthesis from type II supernovae. The spectral slope of the afterglow shows no signs for cosmic dust along the line of sight in the GRB host galaxy, which itself remained undetected (R > 26.2). At the given redshift no supernova component affected the light from the GRB afterglow, so that the optical transient was essentially only powered by the radiation from the GRB fireball, allowing for a detailed investigation of the color evolution of the afterglow light. In our data set no obvious evidence for color changes has been found before, during, or after the smooth break in the light curve approximately 1 day after the burst. In comparison with investigations by others, our data favor the interpretation that the afterglow began to develop into a homogeneous interstellar medium before the break in the light curve became apparent.

GRB 111005A at z = 0.0133 and the Prospect of Establishing Long-Short GRB/GW Association

NASA Astrophysics Data System (ADS)

Wang, Yuan-Zhu; Huang, Yong-Jia; Liang, Yun-Feng; Li, Xiang; Jin, Zhi-Ping; Zhang, Fu-Wen; Zou, Yuan-Chuan; Fan, Yi-Zhong; Wei, Da-Ming

2017-12-01

GRB 111005A, a long-duration gamma-ray burst (GRB) that occurred within a metal-rich environment that lacks massive stars with {M}{ZAMS}≥slant 15 {M}⊙ , is not coincident with supernova emission down to a stringent limit and thus should be classified as a “long-short” GRB (lsGRB; also known as an SN-less long GRB or hybrid GRB), like GRB 060505 and GRB 060614. In this work, we show that in the neutron star merger model the non-detection of the optical/infrared emission of GRB 111005A requires sub-relativistic neutron-rich ejecta with a mass of ≤slant 0.01 {M}⊙ , which is (significantly) less massive than that of GRB 130603B, GRB 060614, GRB 050709, and GRB 170817A. The lsGRBs are found to have a high rate density and the neutron star merger origin model can be unambiguously tested by the joint observations of the second-generation gravitational-wave (GW) detectors and the full-sky gamma-ray monitors such as Fermi-GBM and the proposed GECAM. If no lsGRB/GW association is observed in the 2020s, alternative scenarios have to be systematically investigated. With the detailed environmental information achievable for the nearby events, a novel kind of merger or explosion origin may be identified.

MITSuME Telescope Observation of GRB080506

NASA Astrophysics Data System (ADS)

Mori, Y. A.; Kawai, N.; Arimoto, M.; Yoshida, M.; Ohta, K.

2009-05-01

We report the multicolor early afterglow observation of a 200 s-long GRB080506 with the 50 cm MITSuME Telescopes at Akeno and Okayama, Japan. We started observations of the afterglow at 117 s after the trigger at Akeno when the prompt emission was still ongoing, and 253 s after the trigger at Okayama. We find no counterpart for the X-ray flare in the optical light curve, implying that the X-ray and optical emission in the early afterglow have different origins. We also found a temporal break at about 1000 s in the optical light curve, which we interpret as the passing of the spectral peak at νm and derive constraints on the physical parameters based on the synchrotron shock model. The SED in the optical band suggests a significant absorption in the host galaxy, well fitted with the LMC dust model with E(B-V)~0.2 and redshift z~2.2.

Short Gamma-ray Bursts: Observations and Physics

NASA Astrophysics Data System (ADS)

Janka, H.-Thomas

2007-04-01

The aim of the workshop, which will be held at the scenic Ringberg castle, is supposed to bring together astrophysicists, physicists, and astronomers from different fields in order to discuss recent observational and theoretical discoveries and developments on short gamma-ray bursts. In particular, we plan to address the following topics: * recent short GRB observations * environments and host galaxies of short GRBs * is there a 3rd class of GRBs? * modeling GRB engines and jet outflows * rate and redshift predictions for short GRBs * the fireball model and short GRBs * gravitational-wave signals from short GRBs * neutrino signals from short GRBs * microphysics needed for modeling short GRBs and their engines Scientific and Local organizing committee members: H.-Thomas Janka (Max Planck Institute for Astrophysics, Garching), Miguel Aloy (University of Valencia), Jochen Greiner (Max Planck Institute for Extraterrestrial Physics), Sandra Savaglio (Max Planck Institute for Extraterrestrial Physics), Shri Kulkarni (California Institute of Technology, Pasadena)

CONSTRAINTS ON MACHO DARK MATTER FROM COMPACT STELLAR SYSTEMS IN ULTRA-FAINT DWARF GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, Timothy D.

2016-06-20

I show that a recently discovered star cluster near the center of the ultra-faint dwarf galaxy Eridanus II provides strong constraints on massive compact halo objects (MACHOs) of ≳5 M {sub ⊙} as the main component of dark matter. MACHO dark matter will dynamically heat the cluster, driving it to larger sizes and higher velocity dispersions until it dissolves into its host galaxy. The stars in compact ultra-faint dwarf galaxies themselves will be subject to the same dynamical heating; the survival of at least 10 such galaxies places independent limits on MACHO dark matter of masses ≳10 M {sub ⊙}.more » Both Eri II’s cluster and the compact ultra-faint dwarfs are characterized by stellar masses of just a few thousand M {sub ⊙} and half-light radii of 13 pc (for the cluster) and ∼30 pc (for the ultra-faint dwarfs). These systems close the ∼20–100 M {sub ⊙} window of allowed MACHO dark matter and combine with existing constraints from microlensing, wide binaries, and disk kinematics to rule out dark matter composed entirely of MACHOs from ∼10{sup −7} M {sub ⊙} up to arbitrarily high masses.« less

Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target.

PubMed

Watson, Gabrielle M; Lucas, William A H; Gunzburg, Menachem J; Wilce, Jacqueline A

2017-01-01

Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigated the molecular basis for the specificity of a Grb7 SH2-domain targeted peptide inhibitor. We identified that arginine 462 in the BC loop is unique to Grb7 compared to Grb2, another SH2 domain bearing protein that shares the same consensus binding motif as Grb7. Using surface plasmon resonance we demonstrated that Grb7-SH2 binding to G7-18NATE is reduced 3.3-fold when the arginine is mutated to the corresponding Grb2 amino acid. The reverse mutation in Grb2-SH2 (serine to arginine), however, was insufficient to restore binding of G7-18NATE to Grb2-SH2. Further, using a microarray, we confirmed that G7-18NATE is specific for Grb7 over a panel of 79 SH2 domains, and identified that leucine at the βD6 position may also be a requirement for Grb7-SH2 binding. This study provides insight into the specificity defining features of Grb7 for the inhibitor molecule G7-18NATE, that will assist in the development of improved Grb7 targeted inhibitors.

Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target

PubMed Central

Watson, Gabrielle M.; Lucas, William A. H.; Gunzburg, Menachem J.; Wilce, Jacqueline A.

2017-01-01

Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigated the molecular basis for the specificity of a Grb7 SH2-domain targeted peptide inhibitor. We identified that arginine 462 in the BC loop is unique to Grb7 compared to Grb2, another SH2 domain bearing protein that shares the same consensus binding motif as Grb7. Using surface plasmon resonance we demonstrated that Grb7-SH2 binding to G7-18NATE is reduced 3.3-fold when the arginine is mutated to the corresponding Grb2 amino acid. The reverse mutation in Grb2-SH2 (serine to arginine), however, was insufficient to restore binding of G7-18NATE to Grb2-SH2. Further, using a microarray, we confirmed that G7-18NATE is specific for Grb7 over a panel of 79 SH2 domains, and identified that leucine at the βD6 position may also be a requirement for Grb7-SH2 binding. This study provides insight into the specificity defining features of Grb7 for the inhibitor molecule G7-18NATE, that will assist in the development of improved Grb7 targeted inhibitors. PMID:29018805

A direct localization of a fast radio burst and its host.

PubMed

Chatterjee, S; Law, C J; Wharton, R S; Burke-Spolaor, S; Hessels, J W T; Bower, G C; Cordes, J M; Tendulkar, S P; Bassa, C G; Demorest, P; Butler, B J; Seymour, A; Scholz, P; Abruzzo, M W; Bogdanov, S; Kaspi, V M; Keimpema, A; Lazio, T J W; Marcote, B; McLaughlin, M A; Paragi, Z; Ransom, S M; Rupen, M; Spitler, L G; van Langevelde, H J

2017-01-04

Fast radio bursts are astronomical radio flashes of unknown physical nature with durations of milliseconds. Their dispersive arrival times suggest an extragalactic origin and imply radio luminosities that are orders of magnitude larger than those of all known short-duration radio transients. So far all fast radio bursts have been detected with large single-dish telescopes with arcminute localizations, and attempts to identify their counterparts (source or host galaxy) have relied on the contemporaneous variability of field sources or the presence of peculiar field stars or galaxies. These attempts have not resulted in an unambiguous association with a host or multi-wavelength counterpart. Here we report the subarcsecond localization of the fast radio burst FRB 121102, the only known repeating burst source, using high-time-resolution radio interferometric observations that directly image the bursts. Our precise localization reveals that FRB 121102 originates within 100 milliarcseconds of a faint 180-microJansky persistent radio source with a continuum spectrum that is consistent with non-thermal emission, and a faint (twenty-fifth magnitude) optical counterpart. The flux density of the persistent radio source varies by around ten per cent on day timescales, and very long baseline radio interferometry yields an angular size of less than 1.7 milliarcseconds. Our observations are inconsistent with the fast radio burst having a Galactic origin or its source being located within a prominent star-forming galaxy. Instead, the source appears to be co-located with a low-luminosity active galactic nucleus or a previously unknown type of extragalactic source. Localization and identification of a host or counterpart has been essential to understanding the origins and physics of other kinds of transient events, including gamma-ray bursts and tidal disruption events. However, if other fast radio bursts have similarly faint radio and optical counterparts, our findings imply that direct subarcsecond localizations may be the only way to provide reliable associations.

Confirmation of the E(sup src)(sub Peak)-E(sub iso) (Amati) relation from the x-ray flash XRF 050416A observed by the Swift burst alert telescope

NASA Technical Reports Server (NTRS)

Sakamoti, T.; Barbier, L.; Barthelmy, S. D.; Cummings, J. R.; Fenimore, E. E.; Gehrels, N.; Hullinger, D.; Krimm, H. A.; Markwardt, C. B.

2006-01-01

We report Swift Burst Alert Telescope (BAT) observations of the X-ray flash (XRF) XRF 050416A. The fluence ratio between the 15-25 and 25-50 keV energy bands of this event is 1.5, thus making it the softest gamma-ray burst (GRB) observed by BAT so far. The spectrum is well fitted by a Band function with E(sup obs)(sub peak) of 15.0(sup +2.3)(sub -2.7) keV. Assuming the redshift of the host galaxy (z = 0.6535), the isotropic equivalent radiated energy E(sub iso) and the peak energy at the GRB rest frame (E(sup src)(sub peak)) of XRF 050416A are not only consistent with the correlation found by Amati et al. and extended to XRFs by Sakamoto et al. but also fill in the gap of this relation around the 30-80 keV range of E(sup src)(sub peak). This result tightens the validity of the E(sup src)(sub Peak)-E(sup src)(sub peak) relation from XRFs to GRBs. We also find that the jet break time estimated using the empirical relation between E(sup src)(sub peak) and the collimation corrected energy E(sub gamma), is inconsistent with the afterglow observation by the Swift X-Ray Telescope. This could be due to the extra external shock emission overlaid around the jet break time or to the nonexistence of a jet break feature for XRFs, which might be a further challenge for GRB jet emission models and XRF/GRB unification scenarios.

The Nature of the Remarkable Transient GRB 110328A

NASA Astrophysics Data System (ADS)

Fruchter, Andrew

2010-09-01

One orbit was approved for GO/DD 12447. The PI was given permission to use time under his related approved GRB program, 12370, for subsequent observations of this GRB. To allow the second visit to go forward quickly, it was kept on the schedule as GO/DD 12447, but the orbit was charged to GO 12370. As a result, THE SECOND VISIT OF 12447 HAS THE PROPRIETARY PERIOD ASSOCIATED WITH 12370. We apologize for the confusion caused by this change. However, it was done to allow rapid observations of an unusual astrophysical object.We propose HST observations of the extraordinary transient, GRB 110328A. This object triggered the Swift automatic burst detection twice over the course of about ninety minutes, and has continued to be a bright X-ray source for the two days since. While this behavior might typically suggest a Galactic source, the high Galactic latitude of the object, and its coincidence with a star-forming galaxy at z=0.35 instead suggests a new type of extragalactic transient. WFC3 imaging in the optical and NIR will allow us to search for a varying point source to far greater depth than could be done from the ground, given the presence of an apparent host, and the use of the F160W filter may allow us to pierce enshrouding dust, if extinction is the reason for the present lack of a detection in the optical. While we do not yet know the astrophysical source of this transient, it appears unique among the hundreds of transients so far detected by Swift. This alone should provide strong grounds for HST observations of this unusual and potentially important object.

Polarimetry and Photometry of Gamma-Ray Bursts with RINGO2

NASA Astrophysics Data System (ADS)

Steele, I. A.; Kopač, D.; Arnold, D. M.; Smith, R. J.; Kobayashi, S.; Jermak, H. E.; Mundell, C. G.; Gomboc, A.; Guidorzi, C.; Melandri, A.; Japelj, J.

2017-07-01

We present a catalog of early-time (˜ {10}2-{10}4 s) photometry and polarimetry of all gamma-ray burst (GRB) optical afterglows observed with the RINGO2 imaging polarimeter on the Liverpool Telescope. Of the 19 optical afterglows observed, the following nine were bright enough to perform photometry and attempt polarimetry: GRB 100805A, GRB 101112A, GRB 110205A, GRB 110726A, GRB 120119A, GRB 120308A, GRB 120311A, GRB 120326A, and GRB 120327A. We present multiwavelength light curves for these 9 GRBs, together with estimates of their optical polarization degrees and/or limits. We carry out a thorough investigation of detection probabilities, instrumental properties, and systematics. Using two independent methods, we confirm previous reports of significant polarization in GRB 110205A and 120308A, and report the new detection of P={6}-2+3% in GRB101112A. We discuss the results for the sample in the context of the reverse- and forward-shock afterglow scenario, and show that GRBs with detectable optical polarization at early time have clearly identifiable signatures of reverse-shock emission in their optical light curves. This supports the idea that GRB ejecta contain large-scale magnetic fields, and it highlights the importance of rapid-response polarimetry.

GRB 060614 in the canonical fireshell model

NASA Astrophysics Data System (ADS)

Caito, L.; Bernardini, M. G.; Bianco, C. L.; Dainotti, M. G.; Guida, R.; Ruffini, R.

2008-10-01

Gamma-Ray Burst (GRB) 060614 is the first nearby long duration GRB clearly not associated to any bright Ib/c Supernova. The explosion of this burst undermines one of the fundamental assumptions of the standard scenario and opens new horizons and hints of investigation. GRB 060614, hardly classifiable as a short GRB, is not either a ``typical'' long GRB since it occurs in a low star forming region. Moreover, it presents deep similarities with GRB 970228, which is the prototype of the ``fake'' short bursts, or better canonical GRBs disguised as short ones. Within the ``fireshell'' model ([1]), we test if this ``anomalous'' source can be a disguised short GRB([2]).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ben-Ami, Sagi; Gal-Yam, Avishay; Yaron, Ofer

We present the discovery and extensive early-time observations of the Type Ic supernova (SN) PTF12gzk. Our light curves show a rise of 0.8 mag within 2.5 hr. Power-law fits (f(t){proportional_to}(t - t{sub 0}) {sup n}) to these data constrain the explosion date to within one day. We cannot rule out a quadratic fireball model, but higher values of n are possible as well for larger areas in the fit parameter space. Our bolometric light curve and a dense spectral sequence are used to estimate the physical parameters of the exploding star and of the explosion. We show that the photometricmore » evolution of PTF12gzk is slower than that of most SNe Ic. The high ejecta expansion velocities we measure ({approx}30, 000 km s{sup -1} derived from line minima four days after explosion) are similar to the observed velocities of broad-lined SNe Ic associated with gamma-ray bursts (GRBs) rather than to normal SN Ic velocities. Yet, this SN does not show the persistent broad lines that are typical of broad-lined SNe Ic. The host-galaxy characteristics are also consistent with GRB-SN hosts, and not with normal SN Ic hosts. By comparison with the spectroscopically similar SN 2004aw, we suggest that the observed properties of PTF12gzk indicate an initial progenitor mass of 25-35 M{sub Sun} and a large ((5-10) Multiplication-Sign 10{sup 51} erg) kinetic energy, the later being close to the regime of GRB-SN properties.« less

Deadly Dark Matter Cusps versus Faint and Extended Star Clusters: Eridanus II and Andromeda XXV

NASA Astrophysics Data System (ADS)

Amorisco, Nicola C.

2017-07-01

The recent detection of two faint and extended star clusters in the central regions of two Local Group dwarf galaxies, Eridanus II and Andromeda XXV, raises the question of whether clusters with such low densities can survive the tidal field of cold dark matter halos with central density cusps. Using both analytic arguments and a suite of collisionless N-body simulations, I show that these clusters are extremely fragile and quickly disrupted in the presence of central cusps ρ ˜ {r}-α with α ≳ 0.2. Furthermore, the scenario in which the clusters were originally more massive and sank to the center of the halo requires extreme fine tuning and does not naturally reproduce the observed systems. In turn, these clusters are long lived in cored halos, whose central regions are safe shelters for α ≲ 0.2. The only viable scenario for hosts that have preserved their primordial cusp to the present time is that the clusters formed at rest at the bottom of the potential, which is easily tested by measurement of the clusters proper velocity within the host. This offers means to readily probe the central density profile of two dwarf galaxies as faint as {L}V˜ 5× {10}5 {L}⊙ and {L}V˜ 6× {10}4 {L}⊙ , in which stellar feedback is unlikely to be effective.

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.

PubMed

Yan, Xiao; Himburg, Heather A; Pohl, Katherine; Quarmyne, Mamle; Tran, Evelyn; Zhang, Yurun; Fang, Tiancheng; Kan, Jenny; Chao, Nelson J; Zhao, Liman; Doan, Phuong L; Chute, John P

2016-11-01

Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hematopoietic stem cell (HSC) self-renewal and regeneration. Deletion of the maternal allele of Grb10 in mice (Grb10 m/+ mice) substantially increased HSC long-term repopulating capacity, as compared to that of Grb10 +/+ mice. After total body irradiation (TBI), Grb10 m/+ mice demonstrated accelerated HSC regeneration and hematopoietic reconstitution, as compared to Grb10 +/+ mice. Grb10-deficient HSCs displayed increased proliferation after competitive transplantation or TBI, commensurate with upregulation of CDK4 and Cyclin E. Furthermore, the enhanced HSC regeneration observed in Grb10-deficient mice was dependent on activation of the Akt/mTORC1 pathway. This study reveals a function for the imprinted gene Grb10 in regulating HSC self-renewal and regeneration and suggests that the inhibition of Grb10 can promote hematopoietic regeneration in vivo. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Joint Discussion/Mini-Workshop: Gamma-Ray Bursts and their Hosts

NASA Technical Reports Server (NTRS)

Fishman, Gerald J.

2000-01-01

The observed gamma-ray temporal, spectral, intensity and spatial distribution characteristics of GRBs, primarily from data obtained from the Compton Observatory, will be described. The talk will concentrate on recent studies of burst properties, correlations of GRB parameters and other statistical studies that have only recently come to light with the unprecedented sample of over two thousand GRBs, along with some mention of studies in progress by members of the BATSE team.

The GOES-R Rebroadcast (GRB) Data Stream Simulator

NASA Astrophysics Data System (ADS)

Dittberner, G. J.; Gibbons, K.; Czopkiewicz, E.; Miller, C.; Brown-Bergtold, B.; Haman, B.; Marley, S.

2013-12-01

GOES Rebroadcast (GRB) signals in the GOES-R era will replace the current legacy GOES Variable (GVAR) signal and will have substantially different characteristics, including a change in data rate from a single 2.1 Mbps stream to two digital streams of 15.5 Mbps each. Five GRB Simulators were developed as portable systems that output a high-fidelity stream of Consultative Committee for Space Data Systems (CCSDS) formatted GRB packet data equivalent to live GRB data. The data are used for on-site testing of user ingest and data handling systems known as field terminal sites. The GRB Simulator is a fully self-contained system which includes all software and hardware units needed for operation. The operator manages configurations to edit preferences, define individual test scenarios, and manage event logs and reports. Simulations are controlled by test scenarios, which are scripts that specify the test data and provide a series of actions for the GRB Simulator to perform when generating GRB output. Scenarios allow for the insertion of errors or modification of GRB packet headers for testing purposes. The GRB Simulator provides a built-in editor for managing scenarios. The GRB Simulator provides GRB data as either baseband (digital) or Intermediate Frequency (IF) output to the test system. GRB packet data are sent in the same two output streams used in the operational system: one for Left Hand Circular Polarization (LHCP) and one for Right Hand Circular Polarization (RHCP). Use of circular polarization in the operational system allows the transmitting antenna to multiplex the two digital streams into the same signal, thereby doubling the available bandwidth. The GRB Simulator is designed to be used at sites that receive the GRB downlink.

Evidence for Dynamically Driven Formation of the GW170817 Neutron Star Binary in NGC 4993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palmese, A.; et al.

2017-11-09

We present a study of NGC 4993, the host galaxy of the GW170817 gravitational wave event, the GRB170817A short gamma-ray burst (sGRB) and the AT2017gfo kilonova. We use Dark Energy Camera imaging, AAT spectra and publicly available data, relating our findings to binary neutron star (BNS) formation scenarios and merger delay timescales. NGC4993 is a nearby (40 Mpc) early-type galaxy, withmore » $i$$-band S\\'ersic index $$n=4.0$ and low asymmetry ($$A=0.04\\pm 0.01$$). These properties are unusual for sGRB hosts. However, NGC4993 presents shell-like structures and dust lanes indicative of a recent galaxy merger, with the optical transient located close to a shell. We constrain the star formation history (SFH) of the galaxy assuming that the galaxy merger produced a star formation burst, but find little to no on-going star formation in either spatially-resolved broadband SED or spectral fitting. We use the best-fit SFH to estimate the BNS merger rate in this type of galaxy, as $$R_{NSM}^{gal}= 5.7^{+0.57}_{-3.3} \\times 10^{-6} {\\rm yr}^{-1}$$. If star formation is the only considered BNS formation scenario, the expected number of BNS mergers from early-type galaxies detectable with LIGO during its first two observing seasons is $$0.038^{+0.004}_{-0.022}$$, as opposed to $$\\sim 0.5$$ from all galaxy types. Hypothesizing that the binary system formed due to dynamical interactions during the galaxy merger, the subsequent time elapsed can constrain the delay time of the BNS coalescence. By using velocity dispersion estimates and the position of the shells, we find that the galaxy merger occurred $$t_{\\rm mer}\\lesssim 200~{\\rm Myr}$$ prior to the BNS coalescence.« less

Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7.

PubMed

Pandey, A; Liu, X; Dixon, J E; Di Fiore, P P; Dixit, V M

1996-05-03

Adapter proteins containing Src homology 2 (SH2) domains link transmembrane receptor protein-tyrosine kinases to downstream signal transducing molecules. A family of SH2 containing adapter proteins including Grb7 and Grb10 has been recently identified. We had previously shown that Grb10 associates with Ret via its SH2 domain in an activation-dependent manner (Pandey, A., Duan, H., Di Fiore, P.P., and Dixit, V.M. (1995) J. Biol, Chem. 270, 21461-21463). We now demonstrate that the related adapter molecule Grb7 also associates with Ret in vitro and in vivo, and that the binding of the SH2 domain of Grb7 to Ret is direct. This binding is dependent upon Ret autophosphorylation since Grb7 is incapable of binding a kinase-defective mutant of Ret. Thus two members of the Grb family, Grb7 and Grb10, likely relay signals emanating from Ret to other, as yet, unidentified targets within the cell.

Long High Redshift GRB and Xrt/swift Lightcurves

NASA Astrophysics Data System (ADS)

Arkhangelskaja, Irene

At February of 2010 the volume of Swift GRB subset with known redshift consisted of more than 150 bursts. Long GRB redshift distribution analysis has shown that confidence level of single peak approximation of this distribution is only ˜60%. Moreover, more than 40% of GRB are in very heavy tails outside 3σ level for this fit. More detailed analysis of long GRB redshift distribution reveals that at 97% confidence level at least two subgroups could be separated with following parameters: = 0.9 ± 0.1 and = 2.7 ± 0.2. It allows to make conclusion that Swift long GRB sources subset is not uniform. In the presented article attention is paid on the measure of discrepancy of long GRB with z>3 and subset of other long GRB with known redshifts. XRT/Swift lightcurves for these groups of GRB were considered and it have shown that at least 90% XRT/Swift lightcurves for GRB with z>3 are more complicated and have got a number of maxima.

Grb7 protein RA domain oligomerization.

PubMed

Godamudunage, Malika P; Foster, Albert; Warren, Darius; Lyons, Barbara A

2017-08-01

The growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is often coamplified with the erythroblastosis oncogene B 2 receptor in 20% to 30% of breast cancer patients. Grb7 overexpression has been linked to increased cell migration and cancer metastasis. The ras associating and pleckstrin homology domain region of Grb7 has been reported to interact with various other downstream signaling proteins such as four and half Lin11, Isl-1, Mec-3 (LIM) domains isoform 2 and filamin α. These interactions are believed to play a role in regulating Grb7-mediated cell migration function. The full-length Grb7 protein has been shown to dimerize, and the oligomeric state of the Grb7SH2 domain has been extensively studied; however, the oligomerization state of the ras associating and pleckstrin homology domains, and the importance of this oligomerization in Grb7 function, is yet to be fully known. In this study, we characterize the oligomeric state of the Grb7RA domain using size exclusion chromatography, nuclear magnetic resonance, nuclear relaxation studies, glutaraldehyde cross linking, and dynamic light scattering. We report the Grb7RA domain can exist in transient multimeric forms and, based upon modeling results, postulate the potential role of Grb7RA domain oligomerization in Grb7 function. Copyright © 2017 John Wiley & Sons, Ltd.

SN 2013dx associated with GRB 130702A: a detailed photometric and spectroscopic monitoring and a study of the environment

NASA Astrophysics Data System (ADS)

D'Elia, V.; Pian, E.; Melandri, A.; D'Avanzo, P.; Della Valle, M.; Mazzali, P. A.; Piranomonte, S.; Tagliaferri, G.; Antonelli, L. A.; Bufano, F.; Covino, S.; Fugazza, D.; Malesani, D.; Møller, P.; Palazzi, E.

2015-05-01

Aims: Long-duration gamma-ray bursts (GRBs) and broad-line, type Ic supernovae (SNe) are strongly connected. We aim at characterizing SN 2013dx, which is associated with GRB 130702A, through a sensitive and extensive ground-based observational campaign in the optical-IR band. Methods: We monitored the field of the Swift GRB 130702A (redshift z = 0.145) using the 8.2 m VLT, the 3.6 m TNG and the 0.6 m REM telescopes during the time interval between 4 and 40 days after the burst. Photometric and spectroscopic observations revealed the associated type Ic SN 2013dx. Our multiband photometry allowed constructing a bolometric light curve. Results: The bolometric light curve of SN 2013dx resembles that of 2003dh (associated with GRB 030329), but is ~10% faster and ~25% dimmer. From this we infer a synthesized 56Ni mass of ~0.2 M⊙. The multi-epoch optical spectroscopy shows that the SN 2013dx behavior is best matched by SN 1998bw, among the other well-known low-redshift SNe associated with GRBs and XRFs, and by SN 2010ah, an energetic type Ic SN not associated with any GRB. The photospheric velocity of the ejected material declines from ~2.7 × 104 km s-1 at 8 rest frame days from the explosion, to ~3.5 × 103 km s-1 at 40 days. These values are extremely close to those of SN1998bw and 2010ah. We deduce for SN 2013dx a kinetic energy of ~35 × 1051 erg and an ejected mass of ~7 M⊙. This suggests that the progenitor of SN2013dx had a mass of ~25-30 M⊙, which is 15-20% less massive than that of SN 1998bw. Finally, we studied the SN 2013dx environment through spectroscopy of the closeby galaxies: 9 out of the 14 inspected galaxies lie within 0.03 in redshift from z = 0.145, indicating that the host of GRB 130702A/SN 2013dx belongs to a group of galaxies, an unprecedented finding for a GRB-associated SN and, to our knowledge, for long GRBs in general. Based on observations collected at the Italian 3.6-m Telescopio Nazionale Galileo (TNG), operated on the island of La Palma by the Fundacion Galileo Galilei of the INAF (Instituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias under program A27TAC 5, and at the European Southern Observatory, ESO, the VLT/Antu telescope, Paranal, Chile, proposal code: 291.D-5032(A).Appendix A is available in electronic form at http://www.aanda.org

Time-dependent Optical Spectroscopy of GRB 010222: Clues to the Gamma-Ray Burst Environment

NASA Astrophysics Data System (ADS)

Mirabal, N.; Halpern, J. P.; Kulkarni, S. R.; Castro, S.; Bloom, J. S.; Djorgovski, S. G.; Galama, T. J.; Harrison, F. A.; Frail, D. A.; Price, P. A.; Reichart, D. E.; Ebeling, H.; Bunker, A.; Dawson, S.; Dey, A.; Spinrad, H.; Stern, D.

2002-10-01

We present sequential optical spectra of the afterglow of GRB 010222 obtained 1 day apart using the Low-Resolution Imaging Spectrometer (LRIS) and the Echellette Spectrograph and Imager (ESI) on the Keck Telescopes. Three low-ionization absorption systems are spectroscopically identified at z1=1.47688, z2=1.15628, and z3=0.92747. The higher resolution ESI spectrum reveals two distinct components in the highest redshift system at z1a=1.47590 and z1b=1.47688. We interpret the z1b=1.47688 system as an absorption feature of the disk of the host galaxy of GRB 010222. The best-fitted power-law optical continuum and [Zn/Cr] ratio imply low dust content or a local gray dust component near the burst site. In addition, we do not detect strong signatures of vibrationally excited states of H2. If the gamma-ray burst took place in a superbubble or young stellar cluster, there are no outstanding signatures of an ionized absorber either. Analysis of the spectral time dependence at low resolution shows no significant evidence for absorption-line variability. This lack of variability is confronted with time-dependent photoionization simulations designed to apply the observed flux from GRB 010222 to a variety of assumed atomic gas densities and cloud radii. The absence of time dependence in the absorption lines implies that high-density environments are disfavored. In particular, if the GRB environment was dust free, its density was unlikely to exceed nHI=102 cm-3. If depletion of metals onto dust is similar to Galactic values or less than solar abundances are present, then nHI>=2×104 cm-3 is probably ruled out in the immediate vicinity of the burst. Based on data obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA and was made possible with the generous financial support of the W. M. Keck Foundation.

The Most Remote Gamma-Ray Burst

NASA Astrophysics Data System (ADS)

2000-10-01

ESO Telescopes Observe "Lightning" in the Young Universe Summary Observations with telescopes at the ESO La Silla and Paranal observatories (Chile) have enabled an international team of astronomers [1] to measure the distance of a "gamma-ray burst", an extremely violent, cosmic explosion of still unknown physical origin. It turns out to be the most remote gamma-ray burst ever observed . The exceedingly powerful flash of light from this event was emitted when the Universe was very young, less than about 1,500 million years old, or only 10% of its present age. Travelling with the speed of light (300,000 km/sec) during 11,000 million years or more, the signal finally reached the Earth on January 31, 2000. The brightness of the exploding object was enormous, at least 1,000,000,000,000 times that of our Sun, or thousands of times that of the explosion of a single, heavy star (a "supernova"). The ESO Very Large Telescope (VLT) was also involved in trail-blazing observations of another gamma-ray burst in May 1999, cf. ESO PR 08/99. PR Photo 28a/00 : Sky field near GRB 000131 . PR Photo 28b/00 : The fading optical counterpart of GRB 000131 . PR Photo 28c/00 : VLT spectrum of GRB 000131 . What are Gamma-Ray Bursts? One of the currently most active fields of astrophysics is the study of the mysterious events known as "gamma-ray bursts" . They were first detected in the late 1960's by instruments on orbiting satellites. These short flashes of energetic gamma-rays last from less than a second to several minutes. Despite much effort, it is only within the last few years that it has become possible to locate the sites of some of these events (e.g. with the Beppo-Sax satellite ). Since the beginning of 1997, astronomers have identified about twenty optical sources in the sky that are associated with gamma-ray bursts. They have been found to be situated at extremely large (i.e., "cosmological") distances. This implies that the energy release during a gamma-ray burst within a few seconds is larger than that of the Sun during its entire life time (about 10,000 million years). "Gamma-ray bursts" are in fact by far the most powerful events since the Big Bang that are known in the Universe. While there are indications that gamma-ray bursts originate in star-forming regions within distant galaxies, the nature of such explosions remains a puzzle. Recent observations with large telescopes, e.g. the measurement of the degree of polarization of light from a gamma-ray burst in May 1999 with the VLT ( ESO PR 08/99), are now beginning to cast some light on this long-standing mystery. The afterglow of GRB 000131 ESO PR Photo 28a/00 ESO PR Photo 28a/00 [Preview - JPEG: 400 x 475 pix - 41k] [Normal - JPEG: 800 x 949 pix - 232k] [Full-Res - JPEG: 1200 x 1424 pix - 1.2Mb] ESO PR Photo 28b/00 ESO PR Photo 28b/00 [Preview - JPEG: 400 x 480 pix - 67k] [Normal - JPEG: 800 x 959 pix - 288k] [Full-Res - JPEG: 1200 x 1439 pix - 856k] Caption : PR Photo 28a/00 is a colour composite image of the sky field around the position of the gamma-ray burst GRB 000131 that was detected on January 31, 2000. It is based on images obtained with the ESO Very Large Telescope at Paranal. The object is indicated with an arrow, near a rather bright star (magnitude 9, i.e., over 1 million times brighter than the faintest objects visible on this photo). This and other bright objects in the field are responsible for various unavoidable imaging effects, caused by optical reflections (ring-shaped "ghost images", e.g. to the left of the brightest star) and detector saturation effects (horizontal and vertical straight lines and coloured "coronae" at the bright objects, and areas of "bleeding", e.g. below the bright star). PR Photo 28b/00 shows the rapid fading of the optical counterpart of GRB 000131 (slightly left of the centre), by means of exposures with the VLT on February 4 (upper left), 6 (upper right), 8 (lower left) and March 5 (lower right). It is no longer visible on the last photo. Technical information about these photos is available below. A gamma-ray burst was detected on January 31, 2000, by an international network of satellites ( Ulysses , NEAR and Konus ) via the InterPlanetary Network (IPN) [2]. It was designated GRB 000131 according to the date of the event. From geometric triangulation by means of the measured, exact arrival times of the signal at the individual satellites, it was possible to determine the direction from which the burst came. It was found to be from a point within a comparatively small sky area (about 50 arcmin 2 or 1/10 of the apparent size of the Moon), just inside the border of the southern constellation Carina (The Keel). Follow-up observations were undertaken by a group of European astronomers [1] with the ESO Very Large Telescope at the Paranal Observatory. A comparison of several exposures with the FORS1 multi-mode instrument at the 8.2-m VLT ANTU telescope during the nights of February 3-4 and 5-6 revealed a faint, point-like object that was fading rapidly - this was identified as the optical counterpart of the gamma-ray burst (the "afterglow"). On the second night, the R-magnitude (brightness) was found to be only 24.4, or 30 million times fainter than visible with the unaided eye in a dark sky. It was also possible to observe it with a camera at the 1.54-m Danish Telescope at the La Silla Observatory , albeit only in a near-infrared band and with a 1-hour exposure. Additional observations were made on February 8 with the SOFI multi-mode instrument at the ESO 3.58-m New Technology Telescope (NTT) at La Silla. The observations were performed partly by the astronomers from the group, partly in "service mode" by ESO staff at La Silla and Paranal. The observations showed that the light from the afterglow was very red, without blue and green light. This indicated a comparatively large distance and, assuming that the light from the explosion would originally have had the same colour (spectral distribution) as that of optical counterparts of other observed gamma-ray bursts, a photometric redshift of 4.35 to 4.70 was deduced [3]. A spectrum of GRB 000131 ESO PR Photo 28c/00 ESO PR Photo 28c/00 [Preview - JPEG: 400 x 332 pix - 22k] [Normal - JPEG: 800 x 663 pix - 62k] Caption : PR Photo 28c/00 shows the spectrum of the afterglow of GRB 000131 , obtained during a 3-hr exposure with the FORS1 multi-mode instrument at VLT ANTU on February 8, 2000. The "Lyman-alpha break" at wavelength 670.1 nm is indicated. Technical information about this photo is available below. An accurate measurement of the redshift - hence the distance - requires spectroscopic observations. A spectrum of GRB 000131 was therefore obtained on February 8, 2000, cf. PR Photo 28c/00 . At this time, the brightness had decreased further and the object had become so faint (R-magnitude 25.3) that a total of 3 hours of exposure time was necessary with VLT ANTU + FORS1 [4]. Still, this spectrum is quite "noisy". The deduced photometric redshift of GRB 000131 predicts that a "break" will be seen in the red region of the spectrum, at a wavelength somewhere between 650 and 700 nm. This break is caused by the strong absorption of light in intergalactic hydrogen clouds along the line of sight. The effect is known as the "Lyman-alpha forest" and is observed in all remote objects [5]. As PR Photo 28c/00 shows, such a break was indeed found at wavelength 670.1 nm. Virtually all light at shorter wavelengths from the optical counterpart of GRB 000131 is absorbed by intervening hydrogen clouds. From the rest wavelength of the Lyman-alpha break (121.6 nm), the redshift of GRB 000131 is then determined as 4.50, corresponding to a travel time of more than 90% of the age of the Universe . The most distant gamma-ray burst so far The measured redshift of 4.50 makes GRB 000131 the most distant gamma-ray burst known (the previous, spectroscopically confirmed record was 3.42). Assuming an age of the Universe of the order of 12 - 14,000 million years, the look-back time indicates that the explosion took place around the time our own galaxy, the Milky Way, was formed and at least 6,000 million years before the solar system was born. GRB 000131 and other gamma-ray bursts are believed to have taken place in remote galaxies. However, due to the huge distance, it has not yet been possible to see the galaxy in which the GRB 000131 event took place (the "host" galaxy). From the observed fading of the afterglow it is possible to estimate that the maximum brightness of this explosion was at least 10,000 times brighter than the host galaxy. Future studies of gamma-ray bursts The present team of astronomers has now embarked upon a detailed study of the surroundings of GRB 000131 with the VLT. A main goal is to observe the properties of the host galaxy. From the observations of about twenty optical counterparts of gamma-ray bursts identified until now, it is becoming increasingly clear that these very rare events are somehow related to the death of massive, short-lived stars . But despite the accumulating amount of excellent data, the details of the mechanism that leads to such dramatic explosions still remain a puzzle to astrophysicists. The detection and present follow-up observations of GRB 000131 highlight the new possibilities for studies of the extremely distant (and very early) Universe, now possible by means of gamma-ray bursts. When observed with the powerful instruments at a large ground-based telescope like the VLT, this incredibly bright class of cosmological objects may throw light on the fundamental processes of star formation in the infant universe. Of no less interest is the opportunity to analyse the chemical composition of the gas clouds at the epoch galaxies formed, by means of the imprints of the corresponding absorption lines on the afterglow spectrum. Waiting for the opportunity In this context, it would be extremely desirable to obtain very detailed (high-dispersion) spectra of the afterglow of a future gamma-ray burst, soon after the detection and while it is still sufficiently bright. It would for instance be possible to observe a gamma-ray burst like GRB 000131 with the UVES spectrograph at VLT KUEYEN at the moment of maximum brightness (that may have been about magnitude 16). An example of chemical studies of clouds at intermediate distance by means of a more nearby quasar is shown in ESO PR Photo 09h/00. Attempts are therefore now made to shorten considerably the various steps needed to perform such observations. This concerns especially the time needed to identify the counterpart of a gamma-ray burst and - to a lesser extent - the necessary reaction time at the VLT to point UVES towards the object (in theory, a matter of minutes only). The launch of the HETE-2 (High Energy Transient Explorer 2) gamma-ray burst satellite on October 9, 2000, is a major step in this direction. Under optimal conditions, a relative accurate sky position of a gamma-ray burst may henceforth reach the astronomy community within only 10-20 seconds of the first detection by this satellite. More information The research described in this press release is the subject of a scientific article by the team, entitled "VLT Identification of the optical afterglow of the gamma-ray burst GRB 000131 at z = 4.50" ; it will appear in a special VLT-issue (Letters to the Editor) of the European journal Astronomy & Astrophysics (December 1, 2000). The results are being presented today (October 18) at the joint CNR/ESO meeting on "Gamma-Ray Burst in the Afterglow Era" in Rome, Italy. Note also the related article in the ESO Messenger (No. 100, p. 32, June 2000). Notes [1]: The team consists of Michael Andersen (University of Oulu, Finland), Holger Pedersen, Jens Hjorth, Brian Lindgren Jensen, Lisbeth Fogh Olsen, Lise Christensen (University of Copenhagen, Denmark), Leslie Hunt (Centro per l'Astronomia Infrarossa e lo Studio del Mezzo, Florence, Italy), Javier Gorosabel (Danish Space Research Institute, Denmark), Johan Fynbo, Palle Møller (European Southern Observatory), Richard Marc Kippen (University of Alabama in Huntsville and NASA/Marshall Space Flight Center, USA), Bjarne Thomsen (University of Århus, Denmark), Marianne Vestergaard (Ohio State University, USA), Nicola Masetti, Eliana Palazzi (Instituto Tecnologie e Studio Radiazoni Extraterresti, Bologna, Italy) Kevin Hurley (University of California, Berkeley, USA), Thomas Cline (NASA Goddard Space Flight Center, Greenbelt, USA), Lex Kaper (Sterrenkundig Instituut ``Anton Pannekoek", the Netherlands) and Andreas O. Jaunsen (formerly University of Oslo, Norway; now ESO-Paranal). [2]: Detailed reports about the early observations of this gamma-ray burst are available at the dedicated webpage within the GRB Coordinates Network website. [3]: The photometric redshift method makes it possible to judge the distance to a remote celestial object (a galaxy, a quasar, a gamma-ray burst afterglow) from its measured colours. It is based on the proportionality between the distance and the velocity along the line of sight (Hubble's law) that reflects the expansion of the Universe. The larger the distance of an object is, the larger is its velocity and, due to the Doppler effect, the spectral shift of its emission towards longer (redder) wavelengths. Thus, the measured colour provides a rough indication of the distance. Examples of this method are shown in ESO PR 20/98 (Photos 48a/00 and 48e/00). [4]: In fact, the object was so faint that the positioning of the spectrograph slit had to be done in "blind" offset, i.e. without actually seeing the object on the slit during the observation. This very difficult observational feat was possible because of excellent preparations by the team of astronomers and the very good precision of the telescope and instrument. [5]: The " Lyman-alpha forest" refers to the crowding of absorption lines from intervening hydrogen clouds, shortward of the strong Lyman-alpha spectral line at rest wavelength 121.6 nm. Good examples in the VLT ANTU + FORS1 spectra of distant quasars are shown in ESO PR Photos 14a-c/99 and, at much higher dispersion, in a spectrum obtained with VLT KUEYEN + UVES, cf. ESO PR 08/00 (Photo 09f/00). Technical information about the photos PR Photo 28a/00 : The photo is based on three 8-min exposures obtained with VLT ANTU and the multi-mode FORS1 instrument. The optical filters were B (seeing 0.9 arcsec; here rendered as blue), V (0.8 arcsec; green) and R (0.7 arcsec; red). The field measures 6.8 x 6.8 arcmin 2. North is up and East is left. PR Photo 28b/00 : The four R-exposures were obtained with VLT ANTU + FORS1 on February 4 (magnitude R = 23.3), 6 (24.4), 8 (25.1) and March 5 (no longer visible). The field measures 48 x 48 arcsec 2. North is up and East is left. PR Photo 28c/00 : The spectrum was obtained during a 3-hr exposure with the FORS1 multi-mode instrument at VLT ANTU on February 8, 2000, when the object's magnitude was only R = 25.3. The mean levels of the spectral continua on either side of the redshifted "Lyman-alpha break" at wavelength 670.1 nm are indicated.

The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling.

PubMed

Giorgetti-Peraldi, S; Murdaca, J; Mas, J C; Van Obberghen, E

2001-07-05

Vascular endothelial growth factor (VEGF) is an important regulator of vasculogenesis and angiogenesis. Activation of VEGF receptors leads to the recruitment of SH2 containing proteins which link the receptors to the activation of signaling pathways. Here we report that Grb10, an adapter protein of which the biological role remains unknown, is tyrosine phosphorylated in response to VEGF in endothelial cells (HUVEC) and in 293 cells expressing the VEGF receptor KDR. An intact SH2 domain is required for Grb10 tyrosine phosphorylation in response to VEGF, and this phosphorylation is mediated in part through the activation of Src. In HUVEC, VEGF increases Grb10 mRNA level. Expression of Grb10 in HUVEC or in KDR expressing 293 cells results in an increase in the amount and in the tyrosine phosphorylation of KDR. In 293 cells, this is correlated with the activation of signaling molecules, such as MAP kinase. By expressing mutants of Grb10, we found that the positive action of Grb10 is independent of its SH2 domain. Moreover, these Grb10 effects on KDR seem to be specific since Grb10 has no effect on the insulin receptor, and Grb2, another adapter protein, does not mimic the effect of Grb10 on KDR. In conclusion, we propose that VEGF up-regulates Grb10 level, which in turn increases KDR molecules, suggesting that Grb10 could be involved in a positive feedback loop in VEGF signaling.

Gamma-Ray Bursts, their Hosts, and their Supernovae

NASA Astrophysics Data System (ADS)

Bersier, David; Rhoads, James; Rest, Armin; Merrill, Michael; Levan, Andrew; Fruchter, Andrew; Gorosabel Urkia, Javier; Kouveliotou, Chryssa; Hjorth, Jens; Castro Cerón, J. M.; Patel, Sandeep; Strolger, Lou; Tanvir, Nial

2005-08-01

We request rapid optical and near-IR followup observations of gamma ray bursts (GRBs), which will exploit unique NOAO capabilities to obtain (a) rapid afterglow identifications and (b) detailed physical information on selected events. We will use the Mosaic cameras on the 4m telescopes for rapid identification of GRB afterglows. These instruments provide unsurpassed sensitivity over a wide field. This cycle, they will (a) help identify low-redshift bursts found by HETE-2, which may constitute a large fraction of low-z bursts even in the Swift era; and (b) search for Swift bursts found by the hard X-ray BAT instrument in case the Swift narrow- field instruments do not find a bright counterpart. Afterglow IDs from this program will provide targets for our imaging and spectroscopy programs with Spitzer and Gemini. Large area near-IR imaging with ISPI and FLAMINGOS, and simultaneous multicolor imaging with SQIID, will help address several open questions about GRBs and their afterglows: (1) Are ``dark'' GRBs (without detected optical afterglows) a consequence of dust absorption in the GRB environment? (2) Are observed breaks in GRB light curves truly wavelength-independent, as predicted under models of beamed burst afterglows? (3) Can IR observations find bursts at extreme redshifts? (4) How well do afterglow models stand up to detailed comparison with high precision spectral slope and light curve measurements?

Grb7 is over-expressed in cervical cancer and facilitate invasion and inhibit apoptosis in cervical cancer cells.

PubMed

Zhao, Hong-Bing; Zhang, Xi-Feng; Jia, Xue-Lin; Wang, Hao-Bin

2017-09-01

Growth factor receptor bound protein-7 (Grb7) is a multi-domain adaptor protein that is co-opted by numerous tyrosine kinases involved in various cellular signaling. The objective of this study was to investigate the expression of Grb7 and its clinicopathological significance in cervical cancer. Utilising immunohistochemical staining, we examined the expression of Grb7 in 120 cases of human cervical cancer tissue and 10 cases of adjacent non-cancerous cervical tissue. The positive rate of Grb7 protein expression was 34.2%, which was significantly higher than that in adjacent non-cancerous cervical tissue (0%, p<0.05). The expression of Grb7 was found to be correlated with age, tumor size, serosal invasion, differentiated degree, tumor stage, early or advanced stage and lymph node metastasis. Kaplan-Meier survival analysis showed that patients with positive Grb7 protein expression had a lower overall survival rate than patients without Grb7 expression. In addition, Grb7 plays an important role in promoting tumor progression, including invasion and anti-apoptosis, in cervical cancer cell line. Down-regulation of Grb7 repressed the expression of MMP-9 and Bcl-2, and increased the expression of Bax in Grb7 knockdown Hela cells. Cell invasion assay showed decreased number of Grb7 knockdown Hela cells (18.7±2.1) compared to Hela cells (65.3±2.5, P<0.05). Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer and Grb7 is a potentially molecular target of cervical cancer chemotherapy. Copyright © 2017 Elsevier GmbH. All rights reserved.

Classifying GRB 170817A/GW170817 in a Fermi duration-hardness plane

NASA Astrophysics Data System (ADS)

Horváth, I.; Tóth, B. G.; Hakkila, J.; Tóth, L. V.; Balázs, L. G.; Rácz, I. I.; Pintér, S.; Bagoly, Z.

2018-03-01

GRB 170817A, associated with the LIGO-Virgo GW170817 neutron-star merger event, lacks the short duration and hard spectrum of a Short gamma-ray burst (GRB) expected from long-standing classification models. Correctly identifying the class to which this burst belongs requires comparison with other GRBs detected by the Fermi GBM. The aim of our analysis is to classify Fermi GRBs and to test whether or not GRB 170817A belongs—as suggested—to the Short GRB class. The Fermi GBM catalog provides a large database with many measured variables that can be used to explore gamma-ray burst classification. We use statistical techniques to look for clustering in a sample of 1298 gamma-ray bursts described by duration and spectral hardness. Classification of the detected bursts shows that GRB 170817A most likely belongs to the Intermediate, rather than the Short GRB class. We discuss this result in light of theoretical neutron-star merger models and existing GRB classification schemes. It appears that GRB classification schemes may not yet be linked to appropriate theoretical models, and that theoretical models may not yet adequately account for known GRB class properties. We conclude that GRB 170817A may not fit into a simple phenomenological classification scheme.

EVIDENCE THAT GAMMA-RAY BURST 130702A EXPLODED IN A DWARF SATELLITE OF A MASSIVE GALAXY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelly, Patrick L.; Filippenko, Alexei V.; Fox, Ori D.

2013-09-20

GRB 130702A is a nearby long-duration gamma-ray burst (LGRB) discovered by the Fermi satellite whose associated afterglow was detected by the Palomar Transient Factory. Subsequent photometric and spectroscopic monitoring has identified a coincident broad-lined Type Ic supernova (SN), and nebular emission detected near the explosion site is consistent with a redshift of z = 0.145. The SN-GRB exploded at an offset of {approx}7.''6 from the center of an inclined r = 18.1 mag red disk-dominated galaxy, and {approx}0.''6 from the center of a much fainter r = 23 mag object. We obtained Keck-II DEIMOS spectra of the two objects andmore » find a 2{sigma} upper limit on their line-of-sight velocity offset of {approx}<60 km s{sup -1}. If we calculate the inclination angle of the massive red galaxy from its axis ratio and assume that its light is dominated by a very thin disk, the explosion would have a {approx}60 kpc central offset, or {approx}9 times the galaxy's half-light radius. A significant bulge or a thicker disk would imply a higher inclination angle and greater central offset. The substantial offset suggests that the faint source is a separate dwarf galaxy. The star-formation rate of the dwarf galaxy is {approx}0.05 M{sub Sun} yr{sup -1}, and we place an upper limit on its oxygen abundance of 12 + log(O/H) < 8.16 dex. The identification of an LGRB in a dwarf satellite of a massive, metal-rich primary galaxy suggests that recent detections of LGRBs spatially coincident with metal-rich galaxies may be, in some cases, superpositions.« less

A search for Fermi bursts associated with supernovae and their frequency of occurrence

NASA Astrophysics Data System (ADS)

Kovacevic, M.; Izzo, L.; Wang, Y.; Muccino, M.; Della Valle, M.; Amati, L.; Barbarino, C.; Enderli, M.; Pisani, G. B.; Li, L.

2014-09-01

Context. Observations suggest that most long duration gamma-ray bursts (GRBs) are connected with broad-line supernovae Ib/c, (SNe-Ibc). The presence of GRB-SNe is revealed by rebrightenings emerging from the optical GRB afterglow 10-15 days, in the rest-frame of the source, after the prompt GRB emission. Aims: Fermi/GBM has a field of view (FoV) about 6.5 times larger than the FoV of Swift, therefore we expect that a number of GRB-SN connections have been missed because of lack of optical and X-ray instruments on board of Fermi, which are essential for revealing SNe associated with GRBs. This has motivated our search in the Fermi catalog for possible GRB-SN events. Methods: The search for possible GRB-SN associations follows two requirements: (1) SNe should fall inside the Fermi/GBM error box of the considered long GRB, and (2) this GRB should occur within 20 days before the SN event. Results: We have found five cases within z< 0.2 fulfilling the above reported requirements. One of them, GRB 130702A-SN 2013dx, was already known to have a GRB-SN association. We have analyzed the remaining four cases and we have concluded that three of them are, very likely, just random coincidences due to the Fermi/GBM large error box associated with each GRB detection. We found one GRB possibly associated with a SN 1998bw-like source, GRB 120121B/SN 2012ba. Conclusions: The very low redshift of GRB 120121B/SN 2012ba (z = 0.017) implies a low isotropic energy of this burst (Eiso = 1.39 × 1048) erg. We then compute the rate of Fermi low-luminosity GRBs connected with SNe to be ρ0,b ≤ 770 Gpc-3 yr-1. We estimate that Fermi/GBM could detect 1-4 GRBs-SNe within z ≤ 0.2 in the next 4 years.

Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules.

PubMed

Pradip, De; Bouzyk, Mark; Dey, Nandini; Leyland-Jones, Brian

2013-01-01

Amplification of human Her2 and its aberrant signaling in 20-30% of early breast cancer patients is responsible for highly aggressive tumors with poor outcome. Grb7 is reported to be co-amplified with Her2. We report a concurrent high expression of mRNA (from FFPE tumor samples; mRNA correlation, Pearson r(2)= 0.806), and high levels of GRB7 protein (immunoblot) in HER2+ breast cancer cell lines. We demonstrated the signaling mechanism of HER2 and downstream effectors that contributes to proliferation and migration. Using HER2+ and trastuzumab-resistant breast cancer cell lines, we identified the interaction between GRB7 and HER2 in the control of HER2+ cell proliferation. Our co-IP data show that GRB7 recruits SHC into the HER2-GRB7 signaling complex. This complex formation leads to activation of RAS-GTP. We also observed that following integrin engagement, GRB7 is phosphorylated at tyrosine in a p-FAK (Y397) dependent manner. This FAK-GRB7 complex leads to downstream activation of RAC1-GTP (responsible for migration) probably through the recruitment of VAV2. Our CO-IP data demonstrate that GRB7 directly binds with VAV2 following fibronectin engagement in HER2+ cells. To address whether GRB7 could serve as a pathway specific therapeutic target, we used siRNA to suppress GRB7 expression. Knockdown of GRB7 expression in the HER2+ breast cancer cell lines decreases RAS activation, cell proliferation, 2D and 3D colony formation and also blocked integrin-mediated RAC1 activation along with integrin-directed cell migration. These findings dissected the HER2-mediated signaling cascade into (1) HER2+ cell proliferation (HER2-GRB7-SHC-RAS) and (2) HER2+ cell migration (alpha5 beta1/alpha4 beta1-FAK-GRB7-VAV2-RAC1). Our data clearly demonstrate that a coupling of GRB7 with HER2 is required for the proliferative and migratory signals in HER2+ breast tumor cells.

Molecular Cloning and Characterization of Growth Factor Receptor Bound-Protein in Clonorchis sinensis

PubMed Central

Bai, Xuelian; Lee, Ji-Yun; Kim, Tae Im; Dai, Fuhong; Lee, Tae-Jin; Hong, Sung-Jong

2014-01-01

Background Clonorchis sinensis causes clonorchiasis, a potentially serious disease. Growth factor receptor-bound protein 2 (Grb2) is a cytosolic protein conserved among animals and plays roles in cellular functions such as meiosis, organogenesis and energy metabolism. In the present study, we report first molecular characters of growth factor receptor bound-protein (CsGrb2) from C. sinensis as counter part of Grb2 from animals and its possible functions in development and organogenesis of C. sinensis. Methodology/Principal Findings A CsGrb2 cDNA clone retrieved from the C. sinensis transcriptome encoded a polypeptide with a SH3-SH2-SH3 structure. Recombinant CsGrb2 was bacterially produced and purified to homogeneity. Native CsGrb2 with estimated molecular weight was identified from C. sinensis adult extract by western blotting using a mouse immune serum to recombinant CsGrb2. CsGrb2 transcripts was more abundant in the metacercariae than in the adults. Immunohistochemical staining showed that CsGrb2 was localized to the suckers, mesenchymal tissues, sperms in seminal receptacle and ovary in the adults, and abundantly expressed in most organs of the metacercariae. Recombinant CsGrb2 was evaluated to be little useful as a serodiagnostic reagent for C. sinesis human infections. Conclusion Grb2 protein found in C. sinensis was conserved among animals and suggested to play a role in the organogenesis, energy metabolism and mitotic spermatogenesis of C. sinensis. These findings from C. sinensis provide wider understanding on diverse function of Grb2 in lower animals such as platyhelminths. PMID:24454892

GRB 090423 IN the Fireshell Scenario: a Canonical GRB at Redshift 8.2

NASA Astrophysics Data System (ADS)

Izzo, Luca; Bernardini, Maria Grazia; Bianco, Carlo Luciano; Caito, Letizia; Patricelli, Barbara; Ruffini, Remo

GRB 090423 is the farthest GRB up to date, with a redshift of about 8.1. We present within the Fireshell scenario a complete analysis of this GRB in the γ-ray band and a detailed analysis also in the X-rays, where we note the existence of a second component. We obtain that the FireShell model gives a good indication for the energetic emitted in the burst, Etot = 1:2x1053 ergs. Moreover we note that GRB 090423 is a long GRB with a relatively high bulk Lorentz Gamma factor at the transparency of the Fireshell. Finally we present a study of this extra component in the context of the synchrotron emission scenario, delineated in.8

Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.

PubMed

Ambaye, Nigus D; Gunzburg, Menachem J; Traore, Daouda A K; Del Borgo, Mark P; Perlmutter, Patrick; Wilce, Matthew C J; Wilce, Jacqueline A

2014-02-01

Human growth factor receptor-bound protein 7 (Grb7) is an adapter protein involved in cell growth, migration and proliferation. It is now recognized that Grb7 is an emerging therapeutic target in specific cancer subtypes. Recently, the discovery of a bicyclic peptide inhibitor that targets the Grb7 SH2 domain, named G7-B1, was reported. In an attempt to probe the foundation of its interaction with Grb7, the crystallization and preliminary data collection of both the apo and G7-B1-bound forms of the Grb7 SH2 domain are reported here. Diffraction-quality crystals were obtained using the hanging-drop vapour-diffusion method. After several rounds of microseeding, crystals of the apo Grb7 SH2 domain were obtained that diffracted to 1.8 Å resolution, while those of the G7-B1-Grb7 SH2 domain complex diffracted to 2.2 Å resolution. The apo Grb7 SH2 domain crystallized in the trigonal space group P63, whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21. The experimental aspects of crystallization, crystal optimization and data collection and the preliminary data are reported.

The UV behaviour of GRB 161219B/SN2016jca

NASA Astrophysics Data System (ADS)

Levan, Andrew

2016-10-01

The connection between long duration gamma-ray bursts and the stripped-envelope supernova is now secure, however, central questions remain about the nature of the supernovae and the power sources that drive them. Progress in these areas can be made through in-depth observations of nearby GRBs, in which the supernova light is sufficiently bright for detailed studies. However, such events are extremely rare, with only a handful of classical long-duration GRBs being found at z<0.2. Here we request observations of the recent GRB 161219B, and its supernova SN 2016jca. Utilising the unique ultraviolet capabilities of HST we will map the UV spectrum and its evolution with time. At a minimum, this will provide a route to tracking the afterglow and decomposing afterglow and supernova and host contributions - diagnostics that ground-based observations alone struggle to achieve. However, our sensitive UV observations will also probe the UV properties of a GRB-SN for the first time, providing insight into the metal content of the progenitor, and crucially into the nature of the central engine, which may power the prompt emission of the burst, and continue to provide energy to event at much later times. Recent observations suggest that in extremum these engines may drive supernovae to exceptional luminosities (the so-called superluminous supernovae) and provide a link between the most powerful explosions in the Universe. Our observations may offer the route to identifying such an engine at work in a lower luminosity supernova, solidifying this link.

GRB 170817A: a short GRB seen off-axis

NASA Astrophysics Data System (ADS)

He, Xin-Bo; Tam, Pak-Hin Thomas; Shen, Rong-Feng

2018-04-01

The angular distribution of gamma-ray burst (GRB) jets is not yet clear. The observed luminosity of GRB 170817A is the lowest among all known short GRBs, which is best explained by the fact that our line of sight is outside of the jet opening angle, θ obs > θ j , where θ obs is the angle between our line of sight and the jet axis. As inferred by gravitational wave observations, as well as radio and X-ray afterglow modeling of GRB 170817A, it is likely that θ obs ∼ 20° – 28°. In this work, we quantitatively consider two scenarios of angular energy distribution of GRB ejecta: a top-hat jet and a structured jet with a power law index s. For the top-hat jet model, we get a large θ j (e.g., θ j > 10°), a rather high local (i.e., z < 0.01) short GRB rate ∼8–15×103, Gpc‑3, yr‑1 (estimated to be 90∼1850 Gpc‑3, yr‑1 in Fong et al.) and an extremely high E peak,0 (on-axis, rest-frame) > 7.5 × 104, keV (∼500, keV for a typical short GRB). For the structured jet model, we use θ obs to give limits on s and θj for typical on-axis luminosity of a short GRB (e.g., 1049 erg s‑1 ∼ 1051 erg s‑1), and a low on-axis luminosity case (e.g., 1049 erg s‑1) gives more reasonable values of s. The structured jet model is more feasible for GRB 170817A than the top-hat jet model due to the rather high local short GRB rate, and the extremely high on-axis E peak,0 almost rules out the top-hat jet model. GRB 170817A is likely a low on-axis luminosity GRB (1049 erg s‑1) with a structured jet.

Development of binding assays for the SH2 domain of Grb7 and Grb2 using fluorescence polarization.

PubMed

Luzy, Jean-Philippe; Chen, Huixiong; Gril, Brunilde; Liu, Wang-Qing; Vidal, Michel; Perdereau, Dominique; Burnol, Anne-Françoise; Garbay, Christiane

2008-02-01

Adaptor proteins Grb7 and Grb2 have been implicated as being 2 potential therapeutic targets in several human cancers, especially those that overexpress ErbB2. These 2 proteins contain both a SH2 domain (Src homology 2) that binds to phosphorylated tyrosine residues contained within ErbB2 and other specific protein targets. Two assays based on enzyme-linked immunosorbent assay and fluorescence polarization methods have been developed and validated to find and rank inhibitors for both proteins binding to the pY(1139). Fluorescence polarization assays allowed the authors to determine quickly and reproducibly affinities of peptides from low nanomolar to high micromolar range and to compare them directly for Grb7 and Grb2. As a result, the assays have identified a known peptidomimetic Grb2 SH2 inhibitor (mAZ-pTyr-(alphaMe)pTyr-Asn-NH(2)) that exhibits the most potent affinity for the Grb7 SH2 domain described to date.

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.

PubMed

Deng, Youping; Bhattacharya, Sujoy; Swamy, O Rama; Tandon, Ruchi; Wang, Yong; Janda, Robert; Riedel, Heimo

2003-10-10

The regulation of the metabolic insulin response by mouse growth factor receptor-binding protein 10 (Grb10) has been addressed in this report. We find mouse Grb10 to be a critical component of the insulin receptor (IR) signaling complex that provides a functional link between IR and p85 phosphatidylinositol (PI) 3-kinase and regulates PI 3-kinase activity. This regulatory mechanism parallels the established link between IR and p85 via insulin receptor substrate (IRS) proteins. A direct association was demonstrated between Grb10 and p85 but was not observed between Grb10 and IRS proteins. In addition, no effect of mouse Grb10 was observed on the association between IRS-1 and p85, on IRS-1-associated PI 3-kinase activity, or on insulin-mediated activation of IR or IRS proteins. A critical role of mouse Grb10 was observed in the regulation of PI 3-kinase activity and the resulting metabolic insulin response. Dominant-negative Grb10 domains, in particular the SH2 domain, eliminated the metabolic response to insulin in differentiated 3T3-L1 adipocytes. This was consistently observed for glycogen synthesis, glucose and amino acid transport, and lipogenesis. In parallel, the same metabolic responses were substantially elevated by increased levels of Grb10. A similar role of Grb10 was confirmed in mouse L6 cells. In addition to the SH2 domain, the Pro-rich amino-terminal region of Grb10 was implicated in the regulation of PI 3-kinase catalytic activity. These regulatory roles of Grb10 were extended to specific insulin mediators downstream of PI 3-kinase including PKB/Akt, glycogen synthase kinase, and glycogen synthase. In contrast, a regulatory role of Grb10 in parallel insulin response pathways including p70 S6 kinase, ubiquitin ligase Cbl, or mitogen-activated protein kinase p38 was not observed. The dissection of the interaction of mouse Grb10 with p85 and the resulting regulation of PI 3-kinase activity should help elucidate the complexity of the IR signaling mechanism.

Allostery Mediates Ligand Binding to Grb2 Adaptor in a Mutually Exclusive Manner

PubMed Central

McDonald, Caleb B.; El Hokayem, Jimmy; Zafar, Nawal; Balke, Jordan E.; Bhat, Vikas; Mikles, David C.; Deegan, Brian J.; Seldeen, Kenneth L.; Farooq, Amjad

2012-01-01

Allostery plays a key role in dictating the stoichiometry and thermodynamics of multi-protein complexes driving a plethora of cellular processes central to health and disease. Herein, using various biophysical tools, we demonstrate that although Sos1 nucleotide exchange factor and Gab1 docking protein recognize two non-overlapping sites within the Grb2 adaptor, allostery promotes the formation of two distinct pools of Grb2-Sos1 and Grb2-Gab1 binary signaling complexes in concert in lieu of a composite Sos1-Grb2-Gab1 ternary complex. Of particular interest is the observation that the binding of Sos1 to the nSH3 domain within Grb2 sterically blocks the binding of Gab1 to the cSH3 domain and vice versa in a mutually exclusive manner. Importantly, the formation of both the Grb2-Sos1 and Grb2-Gab1 binary complexes is governed by a stoichiometry of 2:1, whereby the respective SH3 domains within Grb2 homodimer bind to Sos1 and Gab1 via multivalent interactions. Collectively, our study sheds new light on the role of allostery in mediating cellular signaling machinery. PMID:23334917

Broadband Study of GRB 091127: A Sub-Energetic Burst at Higher Redshift?

NASA Technical Reports Server (NTRS)

Troja, E.; Sakamoto, T.; Guidorzi, C.; Norris, J. P.; Panaitescu, A.; Kobayashi, S.; Omodei, N.; Brown, J. C.; Burrows, D. N.; Evans, P. A.;

A New GRB follow-up Software at TUG

NASA Astrophysics Data System (ADS)

Dindar, M.; Parmaksizoglu, M.; Helhel, S.; Esenoglu, H.; Kirbiyik, H.

2016-12-01

A gamma-ray burst (GRB) optical photometric follow-up system at TUBITAK (Scientic and Technological Research Council of Turkey) National Observatory (TUG) has been planned. It uses the 0.6 m Telescope (T60) and can automatically respond to GRB Coordinates Network (GCN) alerts. The telescopes slew relatively fast, being able to point to a new target field within 30 s upon a request. Whenever available, the 1 m T100 and 2.5 m RTT150 telescopes will be used in the future. As an example in 2015, the GRB software system (will be server side) at T60-telescope responded to GRB alert and started the observation as early as 129 s after the GRB trigger autonomously.

Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy.

PubMed

Dharmawardana, Pathirage G; Peruzzi, Benedetta; Giubellino, Alessio; Burke, Terrence R; Bottaro, Donald P

2006-01-01

Growth factor receptor-bound 2 (Grb2) is a ubiquitously expressed adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. As such, it has been implicated in the oncogenesis of several important human malignancies. In addition to this function, research over the last decade has revealed other fundamental roles for Grb2 in cell motility and angiogenesis--processes that also contribute to tumor growth, invasiveness and metastasis. This functional profile makes Grb2 a high priority target for anti-cancer drug development. Knowledge of Grb2 protein structure, its component Src homology domains and their respective structure-function relationships has facilitated the rapid development of sophisticated drug candidates that can penetrate cells, bind Grb2 with high affinity and potently antagonize Grb2 signaling. These novel compounds offer considerable promise in our growing arsenal of rationally designed anti-cancer therapeutics.

VizieR Online Data Catalog: GRB prompt emission fitted with the DREAM model (Ahlgren+, 2015)

NASA Astrophysics Data System (ADS)

Ahlgren, B.; Larsson, J.; Nymark, T.; Ryde, F.; Pe'Er, A.

2018-01-01

We illustrate the application of the DREAM model by fitting it to two different, bright Fermi GRBs; GRB 090618 and GRB 100724B. While GRB 090618 is well fitted by a Band function, GRB 100724B was the first example of a burst with a significant additional BB component (Guiriec et al. 2011ApJ...727L..33G). GRB 090618 is analysed using Gamma-ray Burst Monitor (GBM) data (Meegan et al. 2009ApJ...702..791M) from the NaI and BGO detectors. For GRB 100724B, we used GBM data from the NaI and BGO detectors as well as Large Area Telescope Low Energy (LAT-LLE) data. For both bursts we selected NaI detectors seeing the GRB at an off-axis angle lower than 60° and the BGO detector as being the best aligned of the two BGO detectors. The spectra were fitted in the energy ranges 8-1000 keV (NaI), 200-40000 keV (BGO) and 30-1000 MeV (LAT-LLE). (2 data files).

Distinct Involvement of the Gab1 and Grb2 Adaptor Proteins in Signal Transduction by the Related Receptor Tyrosine Kinases RON and MET

PubMed Central

Chaudhuri, Amitabha; Xie, Ming-Hong; Yang, Becky; Mahapatra, Kaushiki; Liu, Jinfeng; Marsters, Scot; Bodepudi, Sweta; Ashkenazi, Avi

2011-01-01

Although the signal transduction mechanisms of the receptor tyrosine kinase MET are well defined, less is known about its close relative RON. MET initiates intracellular signaling by autophosphorylation on specific cytoplasmic tyrosines that form docking sites for the adaptor proteins Grb2 and Gab1. Grb2 binds directly and is essential for all of the biological activities of MET. Gab1 docks either directly or indirectly via Grb2 and controls only a subset of MET functions. Because MET and RON possess similar adaptor binding sites, it was anticipated that their adaptor interactions would be conserved. Here we show that in contrast to MET, RON relies primarily on Gab1 for signal transmission. Surprisingly, disruption of the Grb2 docking site of RON or Grb2 depletion augments activity, whereas enhancement of Grb2 binding attenuates Gab1 recruitment and signaling. Hence, RON and MET differ in their adaptor interactions; furthermore, Grb2 performs a novel antagonistic role in the context of RON signaling. PMID:21784853

Time-resolved GRB spectra in the complex radiation of synchrotron and Compton processes

NASA Astrophysics Data System (ADS)

Jiang, Y. G.; Hu, S. M.; Chen, X.; Li, K.; Guo, D. F.; Li, Y. T.; Li, H. Z.; Zhao, Y. Y.; Lin, H. N.; Chang, Z.

2016-03-01

Under the steady-state condition, the spectrum of electrons is investigated by solving the continuity equation under the complex radiation of both the synchrotron and Compton processes. The resulted gamma-ray burst (GRB) spectrum is a broken power law in both the fast and slow cooling phases. On the basis of this electron spectrum, the spectral indices of the Band function in four different phases are presented. In the complex radiation frame, the detail investigation on physical parameters reveals that three models can answer the α ˜ -1 problem, which are the synchrotron plus synchrotron self-Compton in the internal and the external shock models, and the synchrotron plus the external Compton processes in the external shock model. A possible marginal to fast cooling phase transition in GRB 080916C is discussed. The time-resolved spectra in different main pulses of GRB 100724B, GRB 100826A and GRB 130606B are investigated. We found that the flux is proportional to the peak energy in almost all main pulses. A significant (5σ) correlation for Fp ˜ Ep is evident the first main pulse of GRB 100826A, and three marginally significant (3σ) correlations Fp ˜ Ep are found in main pulses of GRB 100826A and GRB 130606B. The correlation between spectral index and Ep at 3 ˜ 4σ level are observed in the first main pulse of GRB 100826A. Such correlations are possible explained in the complex radiation scenario.

Short GRBs: Opening Angles, Local Neutron Star Merger Rate, and Off-axis Events for GRB/GW Association

NASA Astrophysics Data System (ADS)

Jin, Zhi-Ping; Li, Xiang; Wang, Hao; Wang, Yuan-Zhu; He, Hao-Ning; Yuan, Qiang; Zhang, Fu-Wen; Zou, Yuan-Chuan; Fan, Yi-Zhong; Wei, Da-Ming

2018-04-01

The jet breaks in the afterglow light curves of short gamma-ray bursts (SGRBs), rarely detected so far, are crucial for estimating the half-opening angles of the ejecta (θ j) and hence the neutron star merger rate. In this work, we report the detection of jet decline behaviors in GRB 150424A and GRB 160821B, and find θ j ∼ 0.1 rad. Together with five events reported before 2015 and three others “identified” recently (GRB 050709, GRB 060614, and GRB 140903A), we have a sample consisting of nine SGRBs and one long-short GRB with reasonably estimated θ j. In particular, three Swift bursts in the sample have redshifts z ≤ 0.2, with which we estimate the local neutron star merger rate density to be ∼ {1109}-657+1432 {Gpc}}-3 {yr}}-1 or {162}-83+140 {Gpc}}-3 {yr}}-1 if the narrowly beamed GRB 061201 is excluded. Inspired by the typical θ j ∼ 0.1 rad found currently, we further investigate whether the off-beam GRBs (in the uniform jet model) or the off-axis events (in the structured jet model) can significantly enhance the GRB/GW association. For the former, the enhancement is at most moderate, while for the latter the enhancement can be much greater and a high GRB/GW association probability of ∼10% is possible. We also show that the data of GRB 160821B may contain a macronova/kilonova emission component with a temperature of ∼3100 K at ∼3.6 days after the burst and more data are needed to ultimately clarify.

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers

PubMed Central

2015-01-01

Adaptor protein Grb2 binds phosphotyrosines in the epidermal growth factor (EGF) receptor (EGFR) and thereby links receptor activation to intracellular signaling cascades. Here, we investigated how recruitment of Grb2 to EGFR is affected by the spatial organization and quaternary state of activated EGFR. We used the techniques of image correlation spectroscopy (ICS) and lifetime-detected Förster resonance energy transfer (also known as FLIM-based FRET or FLIM–FRET) to measure ligand-induced receptor clustering and Grb2 binding to activated EGFR in BaF/3 cells. BaF/3 cells were stably transfected with fluorescently labeled forms of Grb2 (Grb2–mRFP) and EGFR (EGFR–eGFP). Following stimulation of the cells with EGF, we detected nanometer-scale association of Grb2–mRFP with EGFR–eGFP clusters, which contained, on average, 4 ± 1 copies of EGFR–eGFP per cluster. In contrast, the pool of EGFR–eGFP without Grb2–mRFP had an average cluster size of 1 ± 0.3 EGFR molecules per punctum. In the absence of EGF, there was no association between EGFR–eGFP and Grb2–mRFP. To interpret these data, we extended our recently developed model for EGFR activation, which considers EGFR oligomerization up to tetramers, to include recruitment of Grb2 to phosphorylated EGFR. The extended model, with adjustment of one new parameter (the ratio of the Grb2 and EGFR copy numbers), is consistent with a cluster size distribution where 2% of EGFR monomers, 5% of EGFR dimers, <1% of EGFR trimers, and 94% of EGFR tetramers are associated with Grb2. Together, our experimental and modeling results further implicate tetrameric EGFR as the key signaling unit and call into question the widely held view that dimeric EGFR is the predominant signaling unit. PMID:24697349

GRB2 Interaction with the Ecotropic Murine Leukemia Virus Receptor, mCAT-1, Controls Virus Entry and Is Stimulated by Virus Binding

PubMed Central

Chen, Zeming; Kolokoltsov, Andrey A.; Wang, Jia; Adhikary, Shramika; Lorinczi, Marta; Elferink, Lisa A.

2012-01-01

For retroviruses such as HIV-1 and murine leukemia virus (MLV), active receptor recruitment and trafficking occur during viral entry. However, the underlying mechanisms and cellular factors involved in the process are largely uncharacterized. The viral receptor for ecotropic MLV (eMLV), a classical model for retrovirus infection mechanisms and pathogenesis, is mouse cationic amino acid transporter 1 (mCAT-1). Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein that has been shown to couple cell surface receptors, such as epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor, to intracellular signaling events. Here we examined if GRB2 could also play a role in controlling infection by retroviruses by affecting receptor function. The GRB2 RNA interference (RNAi)-mediated suppression of endogenous GRB2 resulted in a consistent and significant reduction of virus binding and membrane fusion. The binding between eMLV and cells promoted increased GRB2–mCAT-1 interactions, as detected by immunoprecipitation. Consistently, the increased colocalization of GRB2 and mCAT-1 signals was detected by confocal microscopy. This association was time dependent and paralleled the kinetics of cell-virus membrane fusion. Interestingly, unlike the canonical binding pattern seen for GRB2 and growth factor receptors, GRB2–mCAT-1 binding does not depend on the GRB2-SH2 domain-mediated recognition of tyrosine phosphorylation on the receptor. The inhibition of endogenous GRB2 led to a reduction in surface levels of mCAT-1, which was detected by immunoprecipitation and by a direct binding assay using a recombinant MLV envelope protein receptor binding domain (RBD). Consistent with this observation, the expression of a dominant negative GRB2 mutant (R86K) resulted in the sequestration of mCAT-1 from the cell surface into intracellular vesicles. Taken together, these findings suggest a novel role for GRB2 in ecotropic MLV entry and infection by facilitating mCAT-1 trafficking. PMID:22090132

GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.

PubMed

Chen, Zeming; Kolokoltsov, Andrey A; Wang, Jia; Adhikary, Shramika; Lorinczi, Marta; Elferink, Lisa A; Davey, Robert A

2012-02-01

For retroviruses such as HIV-1 and murine leukemia virus (MLV), active receptor recruitment and trafficking occur during viral entry. However, the underlying mechanisms and cellular factors involved in the process are largely uncharacterized. The viral receptor for ecotropic MLV (eMLV), a classical model for retrovirus infection mechanisms and pathogenesis, is mouse cationic amino acid transporter 1 (mCAT-1). Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein that has been shown to couple cell surface receptors, such as epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor, to intracellular signaling events. Here we examined if GRB2 could also play a role in controlling infection by retroviruses by affecting receptor function. The GRB2 RNA interference (RNAi)-mediated suppression of endogenous GRB2 resulted in a consistent and significant reduction of virus binding and membrane fusion. The binding between eMLV and cells promoted increased GRB2-mCAT-1 interactions, as detected by immunoprecipitation. Consistently, the increased colocalization of GRB2 and mCAT-1 signals was detected by confocal microscopy. This association was time dependent and paralleled the kinetics of cell-virus membrane fusion. Interestingly, unlike the canonical binding pattern seen for GRB2 and growth factor receptors, GRB2-mCAT-1 binding does not depend on the GRB2-SH2 domain-mediated recognition of tyrosine phosphorylation on the receptor. The inhibition of endogenous GRB2 led to a reduction in surface levels of mCAT-1, which was detected by immunoprecipitation and by a direct binding assay using a recombinant MLV envelope protein receptor binding domain (RBD). Consistent with this observation, the expression of a dominant negative GRB2 mutant (R86K) resulted in the sequestration of mCAT-1 from the cell surface into intracellular vesicles. Taken together, these findings suggest a novel role for GRB2 in ecotropic MLV entry and infection by facilitating mCAT-1 trafficking.

THE PROPERTIES OF THE 2175 A EXTINCTION FEATURE DISCOVERED IN GRB AFTERGLOWS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zafar, Tayyaba; Watson, Darach; Eliasdottir, Ardis

The unequivocal, spectroscopic detection of the 2175 A bump in extinction curves outside the Local Group is rare. To date, the properties of the bump have been examined in only two gamma-ray burst (GRB) afterglows (GRB 070802 and GRB 080607). In this work, we analyze in detail the detections of the 2175 Angstrom-Sign extinction bump in the optical spectra of two further GRB afterglows: GRB 080605 and 080805. We gather all available optical/near-infrared photometric, spectroscopic, and X-ray data to construct multi-epoch spectral energy distributions (SEDs) for both GRB afterglows. We fit the SEDs with the Fitzpatrick and Massa model withmore » a single or broken power law. We also fit a sample of 38 GRB afterglows, known to prefer a Small Magellanic Cloud (SMC)-type extinction curve, with the same model. We find that the SEDs of GRB 080605 and GRB 080805 at two epochs are fit well with a single power law with a derived extinction of A{sub V} = 0.52{sup +0.13}{sub -0.16} and 0.50{sup +0.13}{sub -0.10}, and 2.1{sup +0.7}{sub -0.6} and 1.5 {+-} 0.2, respectively. While the slope of the extinction curve of GRB 080805 is not well constrained, the extinction curve of GRB 080605 has an unusual very steep far-UV rise together with the 2175 A bump. Such an extinction curve has previously been found in only a small handful of sightlines in the Milky Way. One possible explanation of such an extinction curve may be dust arising from two different regions with two separate grain populations, however we cannot distinguish the origin of the curve. We finally compare the four 2175 A bump sightlines to the larger GRB afterglow sample and to Local Group sightlines. We find that while the width and central positions of the bumps are consistent with what is observed in the Local Group, the relative strength of the detected bump (A{sub bump}) for GRB afterglows is weaker for a given A{sub V} than for almost any Local Group sightline. Such dilution of the bump strength may offer tentative support to a dual dust-population scenario.« less

The origin and location of the 5 March 1979 gamma-ray burst

NASA Technical Reports Server (NTRS)

Kazanas, Demosthenes

1988-01-01

Evidence and arguments concerning the origin and location of the gamma-ray burst (GRB) of March 5, 1979 are reviewed. This GRB has been positionally identified with the SNR 49 in the LMC. Such an association would fix the GRB's distance at 55 kpc, and the observed flux from the GRB would require prodigious energy and luminosity, casting doubt on the GRB's distance and its association with the LMC. Some Kosmos 856 observations which may provide more direct evidence on the energy released are discussed.

Broadband Study of GRB 091127: A Sub-energetic Burst at Higher Redshift?

NASA Astrophysics Data System (ADS)

Troja, E.; Sakamoto, T.; Guidorzi, C.; Norris, J. P.; Panaitescu, A.; Kobayashi, S.; Omodei, N.; Brown, J. C.; Burrows, D. N.; Evans, P. A.; Gehrels, N.; Marshall, F. E.; Mawson, N.; Melandri, A.; Mundell, C. G.; Oates, S. R.; Pal'shin, V.; Preece, R. D.; Racusin, J. L.; Steele, I. A.; Tanvir, N. R.; Vasileiou, V.; Wilson-Hodge, C.; Yamaoka, K.

2012-12-01

GRB 091127 is a bright gamma-ray burst (GRB) detected by Swift at a redshift z = 0.49 and associated with SN 2009nz. We present the broadband analysis of the GRB prompt and afterglow emission and study its high-energy properties in the context of the GRB/SN association. While the high luminosity of the prompt emission and standard afterglow behavior are typical of cosmological long GRBs, its low-energy release (E γ < 3 × 1049 erg), soft spectrum, and unusual spectral lag connect this GRB to the class of sub-energetic bursts. We discuss the suppression of high-energy emission in this burst, and investigate whether this behavior could be connected with the sub-energetic nature of the explosion.

The Study of the Cosmic Gamma-Emission Nonstationary Fluxes Characteristics by the AVS-F Apparatus Data

NASA Astrophysics Data System (ADS)

Kotov, Yu. D.; Arkhangelskaja, I. V.; Arkhangelsky, A. I.; Kuznetsov, S. N.; Glyanenko, A. S.; Kalmykov, P. A.; Amandzholova, D. B.; Samoylenko, V. T.; Yurov, V. N.; Pavlov, A. V.; Chervyakova, O. I.; Afonina, I. V.

The AVS-F apparatus (Russian abbreviation for Amplitude-Time Spectrometry of the Sun) is intended for the solar flares' hard X-ray and gamma-ray emission characteristic studies and for the search and detection of the gamma-ray bursts (GRB). At present over 1,100 events with duration more than 2 s without any coordinate relations to Earth Radiation Belts and South Atlantic Anomaly were separated on the results of preliminary analysis of AVS-F experiment database.About 68 % of the identified events were associated with quasistationary equatorial precipitations-15-30 % count rate increases in the low-energy gamma-band of the AVS-F apparatus over its average value obtained by approximation of these parts with polynomials discovered on some equatorial segments in the ranges of geographic latitude of 25∘ up to +30∘. Several short events with duration of 1-16 ms associated with terrestrial gamma-ray flashes were registered during the experiment. These events were detected above the powerful thunderstorm formations.Solar flares with classes stronger than M1.0 according to the GOES classification were about 7 % of the detected events. Solar flares' hard X-rays and γ-emission were mainly observed during the rise or maximum phases of the emission in the soft X-rays band according to the detectors on board the GOES series satellites data and duration of their registration is less than of the soft X-ray bands. According to the preliminary data analysis gamma-emission with energy over 10 MeV was registered during 12 % of the observed flares. The emission in the energy band E ¿ 100 keV was registered during over 60 faint solar flares (of B and C classes according to the GOES and from several ones γ-quanta with energy up to several tens of MeV were observed.Several spectral line complexes were observed in the spectra of some solar flares stronger than M1.0 in the low-energy gamma-range. Registered spectral features were corresponded to α α-lines, annihilation line, nuclear lines, and neutron capture line on1H (2.223 MeV). In the spectrum of the January 20, 2005 solar flare the feature in the range of 15-21 MeV was detected for the first time. It can be associated with lines of 15.11 MeV (12C +16O) or 20.58 MeV (from neutron radiative capture on3He), or with their combination. Also several e-dominant flares without any gamma-lines in energy spectra were identified. All detected faint solar flares were e-dominant according to the preliminary data analysis.Thin structure with characteristic timescale of 30-160 s was observed at 99 % significance level on some solar flares stronger than M1.0 temporal profiles in the low-energy gamma-band in the energy ranges corresponding to the identified spectral features or whole gamma-band energy boundaries. According to the results of the preliminary analysis during the flare of January 20, 2005, thin structure with timescale from 7 ms to 35 ms was detected at 99 % confidence level in the energy range of 0.1-20 MeV. Some thin structure with characteristic timescale 50-110 s was observed on temporal profiles of several faint events.About 3 % of the identified events were gamma-ray bursts. During some bursts high-energy gamma-emission was observed, for example Emax = 147 ± 3 MeV for GRB050525.

The Transient High Energy Sky and Early Universe Surveyor (THESEUS)

NASA Astrophysics Data System (ADS)

Amati, Lorenzo; O'Brien, Paul T.; Götz, Diego

2016-07-01

The Transient High Energy Sky and Early Universe Surveyor (THESEUS) is a mission concept under development by a large international collaboration aimed at exploiting gamma-ray bursts for investigating the early Universe. The main scientific objectives of THESEUS include: investigating the star formation rate and metallicity evolution of the ISM and IGM up to redshift 9-10, detecting the first generation (pop III) of stars, studying the sources and physics of re-ionization, detecting the faint end of galaxies luminosity function. These goals will be achieved through a unique combination of instruments allowing GRB detection and arcmin localization over a broad FOV (more than 1sr) and an energy band extending from several MeVs down to 0.3 keV with unprecedented sensitivity, as well as on-board prompt (few minutes) follow-up with a 0.6m class IR telescope with both imaging and spectroscopic capabilities. Such instrumentation will also allow THESEUS to unveil and study the population of soft and sub-energetic GRBs, and, more in general, to perform monitoring and survey of the X-ray sky with unprecedented sensitivity.

Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup

PubMed Central

Cowley, Michael; Garfield, Alastair S.; Madon-Simon, Marta; Charalambous, Marika; Clarkson, Richard W.; Smalley, Matthew J.; Kendrick, Howard; Isles, Anthony R.; Parry, Aled J.; Carney, Sara; Oakey, Rebecca J.; Heisler, Lora K.; Moorwood, Kim; Wolf, Jason B.; Ward, Andrew

2014-01-01

Developmental programming links growth in early life with health status in adulthood. Although environmental factors such as maternal diet can influence the growth and adult health status of offspring, the genetic influences on this process are poorly understood. Using the mouse as a model, we identify the imprinted gene Grb10 as a mediator of nutrient supply and demand in the postnatal period. The combined actions of Grb10 expressed in the mother, controlling supply, and Grb10 expressed in the offspring, controlling demand, jointly regulate offspring growth. Furthermore, Grb10 determines the proportions of lean and fat tissue during development, thereby influencing energy homeostasis in the adult. Most strikingly, we show that the development of normal lean/fat proportions depends on the combined effects of Grb10 expressed in the mother, which has the greater effect on offspring adiposity, and Grb10 expressed in the offspring, which influences lean mass. These distinct functions of Grb10 in mother and pup act complementarily, which is consistent with a coadaptation model of imprinting evolution, a model predicted but for which there is limited experimental evidence. In addition, our findings identify Grb10 as a key genetic component of developmental programming, and highlight the need for a better understanding of mother-offspring interactions at the genetic level in predicting adult disease risk. PMID:24586114

Panchromatic Observations of GRB 110205A and Other GRB Optical Prompt Observations Obtained by ROTSE

NASA Astrophysics Data System (ADS)

Zheng, Weikang; with a larger Collaboration

2011-09-01

The leading radiation mechanisms for gamma-ray bursts (GRBs), as predicted by the standard GRB fireball model, include synchrotron radiation, synchrotron self-Compton (SSC), and inverse Compton scattering from thermal photons. Panchromatic observations during GRB prompt emission are important to distinguish the mechanisms. GRB 110205A, triggered by Swift, is also detected by Suzaku, ROTSE-IIIb and BOOTES telescopes when the GRB is still radiating gamma-rays. These panchromatic observations, covering 6 orders of energy range from 1 eV to 5 MeV, will be presented. We clearly discover an interesting two-break energy spectrum for the first time, roughly consistent with the synchrotron spectrum predicted by the standard GRB fireball model. The two break energies can be explained as νc, the synchrotron cooling frequency, and νm, the synchrotron typical frequency. With a sample of GRBs with optical prompt detections from ROTSE observations, one can also constrain the self-absorption frequency, νa. These detailed prompt observations are important to discriminate different mechanisms and thus lead us to a better and deeper understanding of the GRB fireball model. This research is supported by the NASA grant NNX08AV63G and the NSF grant PHY-0801007.

Did a Gamma-Ray Burst Initiate the Late Ordovician Mass Extinction?

NASA Technical Reports Server (NTRS)

Melott, A. L.; Lieberman, B. S.; Laird, C. M.; Martin, L. D.; Medvedov, M. V.; Thomas, B. C.; Cannizzo, J. K.; Gehrels, N.; Jackman, C. H.

2004-01-01

Gamma-ray bursts (hereafter GRB) produce a flux of radiation detectable across the observable Universe. A GRB within our own galaxy could do considerable damage to the Earth's biosphere; rate estimates suggest that a dangerously near GRB should occur on average several times per billion years. At leastfive times in the history of lfe, the Earth experienced mass extinctions that eliminated a large percentage of the biota. Many possible causes have been documented, and GRB may also have contributed. The late Ordovician mass extinction approximately 440 million years ago may be at least partly the result of a GRB. Due to severe depletion of the ozone layer, intense solar ultraviolet radiation is expected to result from a nearby GRB, and some of the patterns of extinction and survivorship at this time may be attributable to elevated levels of UV radiation reaching the Earth. In addition a GRB could trigger the global cooling which occurs at the end of the Ordovician period that follows an interval of relatively warm climate. Intense rapid cooling and glaciation at that time, previously identijied as the probable cause of this mass extinction, may have resultedfiom a GRB.

Rapid Observations of Short-Duration Gamma-Ray Bursts: Accurate Positions Hold the Key to the Progenitor Population

NASA Astrophysics Data System (ADS)

Berger, Edo

2017-09-01

Only 1/4 of all short GRBs are localized to sub-arcsecond accuracy, required for unambiguous host and redshift identifications, determination of the burst environment (disk, bulge, halo, IGM), and assessment of natal kicks. These properties determine the identity and ages of the progenitors, and the GRB explosion physics. Thus, much of our knowledge depends on a handful of events, which are moreover biased to high density environments by virtue of optical/radio detections. Here we propose to double the fraction of events with sub-arcsecond positions, and overcome the density bias, using rapid Chandra observations of bursts with only Swift/XRT positions. Swift data will guarantee Chandra detections at <4 days, and follow-up work will delineate the burst/host properties.

Spectral evolution of GRBs with negative spectral lag using Fermi GBM observations

NASA Astrophysics Data System (ADS)

Chakrabarti, Arundhati; Chaudhury, Kishor; Sarkar, Samir K.; Bhadra, Arunava

2018-06-01

The positive spectral lag of Gamma Ray Bursts (GRBs) is often explained in terms of hard-to-soft spectral evolution of GRB pulses. While positive lags of GRBs is very common, there are few GRB pulses that exhibits negative spectral lags. In the present work we examine whether negative lags of GRBs also can be interpreted in terms of spectral evolution of GRB pulses or not. Using Fermi-GBM data, we identify two GRBs, GRB 090426C and GRB 150213A, with clean pulses that exhibit negative spectral lag. An indication of soft to hard transition has been noticed for the negative spectral lag events from the spectral evolution study. The implication of the present findings on the models of GRB spectral lags are discussed.

Broadband Study of GRB 091127: A Sub-Energetic Burst at Higher Redshift?

DOE PAGES

Troja, E.; Sakamoto, T.; Guidorzi, C.; ...

2012-11-21

GRB 091127 is a bright gamma-ray burst (GRB) detected by Swift at a redshift z = 0.49 and associated with SN 2009nz. In this paper, we present the broadband analysis of the GRB prompt and afterglow emission and study its high-energy properties in the context of the GRB/SN association. While the high luminosity of the prompt emission and standard afterglow behavior are typical of cosmological long GRBs, its low-energy release (E γ < 3 x 10 49 erg), soft spectrum, and unusual spectral lag connect this GRB to the class of sub-energetic bursts. Finally, we discuss the suppression of high-energymore » emission in this burst, and investigate whether this behavior could be connected with the sub-energetic nature of the explosion.« less

The clustering of QSOs and the dark matter halos that host them

NASA Astrophysics Data System (ADS)

Zhao, Dong-Yao; Yan, Chang-Shuo; Lu, Youjun

2013-10-01

The spatial clustering of QSOs is an important measurable quantity which can be used to infer the properties of dark matter halos that host them. We construct a simple QSO model to explain the linear bias of QSOs measured by recent observations and explore the properties of dark matter halos that host a QSO. We assume that major mergers of dark matter halos can lead to the triggering of QSO phenomena, and the evolution of luminosity for a QSO generally shows two accretion phases, i.e., initially having a constant Eddington ratio due to the self-regulation of the accretion process when supply is sufficient, and then declining in rate with time as a power law due to either diminished supply or long term disk evolution. Using a Markov Chain Monte Carlo method, the model parameters are constrained by fitting the observationally determined QSO luminosity functions (LFs) in the hard X-ray and in the optical band simultaneously. Adopting the model parameters that best fit the QSO LFs, the linear bias of QSOs can be predicted and then compared with the observational measurements by accounting for various selection effects in different QSO surveys. We find that the latest measurements of the linear bias of QSOs from both the SDSS and BOSS QSO surveys can be well reproduced. The typical mass of SDSS QSOs at redshift 1.5 < z < 4.5 is ~ (3 - 6) × 1012 h-1 Msolar and the typical mass of BOSS QSOs at z ~ 2.4 is ~ 2 × 1012 h-1 Msolar. For relatively faint QSOs, the mass distribution of their host dark matter halos is wider than that of bright QSOs because faint QSOs can be hosted in both big halos and smaller halos, but bright QSOs are only hosted in big halos, which is part of the reason for the predicted weak dependence of the linear biases on the QSO luminosity.

Sweating the small stuff: simulating dwarf galaxies, ultra-faint dwarf galaxies, and their own tiny satellites

NASA Astrophysics Data System (ADS)

Wheeler, Coral Rose

We study dwarf satellite galaxy quenching using observations from the Geha et al. (2012) NSA/SDSS catalog together with CDM cosmological simulations to facilitate selection and interpretation. We show that fewer than 30% of dwarfs (M* ˜ 108.5-9.5 Msun ) identified as satellites within massive host halos (M host ˜ 1012.5-14 Msun) are quenched. We conclude that whatever the action triggering environmental quenching of dwarf satellites, the process must be highly inefficient. We investigate a series of simple, one-parameter quenching models in order to understand what is required to explain the low quenched fraction and conclude that either the quenching timescale is very long (> 9.5 Gyr, a "slow starvation" scenario) or that the environmental trigger is not well matched to accretion within the virial volume. We further present FIRE/Gizmo hydrodynamic zoom-in simulations of isolated dark matter halos, two each at the mass of classical dwarf galaxies (Mvir ˜ 1010 Msun) and ultra-faint galaxies (Mvir ˜ 10 9 Msun). The resulting central galaxies lie on an extrapolated abundance matching relation from M* ˜ 106 to 104 Msun without a break. Our dwarfs with M* ˜ 106 Msun each have 1-2 well-resolved satellites with M* = 3 - 200 x 103 Msun. Even our isolated ultra-faint galaxies have star-forming subhalos. We combine our results with the ELVIS simulations to show that targeting the ˜ 50 kpc regions around nearby isolated dwarfs could increase the chances of discovering ultra-faint galaxies by ˜35% compared to random pointings. The well-resolved ultra-faint galaxies in our simulations (M * ˜ 3 - 30 x 103 Msun) form within Mpeak ˜ 0.5 - 3 x 109 Msun halos. Each has a uniformly ancient stellar population (> 10 Gyr) owing to reionization-related quenching. More massive systems, in contrast, all have late-time star formation. Our results suggest that Mhalo ˜ 5 x 109 Msun is a probable dividing line between halos hosting reionization "fossils" and those hosting dwarfs that can continue to form stars in isolation after reionization. Finally, we perform a systematic Bayesian analysis of rotation vs. dispersion support (vrot/sigma) in 40 dwarf galaxies throughout the Local Volume (LV) over a stellar mass range 103.5 M sun < M* < 108 Msun. We find that the stars in 80% of the LV dwarf galaxies studied -- both satellites and isolated systems -- are dispersion-supported. These results challenge the traditional view that the stars in gas-rich dwarf irregulars (dIrrs) are distributed in cold, rotationally-supported stellar disks, while gas-poor dwarf spheroidals (dSphs) are kinematically distinct in having dispersion supported stars. We apply the same Bayesian analysis to four of the FIRE/Gizmo hydrodynamic zoom-in simulations of isolated dwarf galaxies (109 Msun < M vir < 1010 Msun) and show that the simulated isolated dIrr galaxies have stellar ellipticities and stellar vrot/sigma ratios that are consistent with the observed population of dIrrs and dSphs without the need to subject these dwarfs to any external perturbations or tidal forces. We posit that most dwarf galaxies form as puffy, dispersion-dominated systems, rather than cold, angular momentum-supported disks. If this is the case, then transforming a dIrr into a dSph may require little more than removing its gas.

VLA Observations Confirm Origin of Gamma Ray Bursts in Short-Lived Stars

NASA Astrophysics Data System (ADS)

1998-06-01

Radio telescope studies of the fiery afterglow of a Gamma Ray Burst have provided astronomers with the best clues yet about the origins of these tremendous cosmic cataclysms since their discovery more than 30 years ago. Observations with the National Science Foundation's (NSF) Very Large Array (VLA) radio telescope confirm that a blast seen to occur on March 29 had its origin in a star-forming region in a distant galaxy. "There are two leading theories for the causes of Gamma Ray Bursts," said Dale Frail of the NSF National Radio Astronomy Observatory (NRAO) in Socorro, NM. "According to one theory, the blasts occur in the death throes of pairs of old stars. The other requires them to arise from exploding, massive, short-lived stars that still reside within the star-forming gas and dust from which they formed. The VLA studies of the burst show that at least this one almost certainly occurred within a star-forming region. This result also explains why half of the Gamma Ray Burst afterglows are not detected by optical telescopes." Frail heads a VLA observing team including Greg Taylor, also of NRAO, and Shri Kulkarni of Caltech, that reported its findings to the American Astronomical Society meeting in San Diego, CA. The March 29 burst was seen clearly by radio telescopes (the accompanying image is GRB 980329 as seen by the VLA) but only very faintly with optical instruments. "That is extremely important," said Taylor. "This burst was very faint at visible wavelengths, brighter at infrared wavelengths and brighter still at radio wavelengths. This is a clear indication that the exploding object was surrounded by dust. Dust is most commonly found in star-forming regions." This strongly favors one of the two leading theories about Gamma Ray Bursts over the other. One explanation for these tremendously energetic fireballs is that a pair of superdense neutron stars collides. The other is that a single, very massive star explodes in a "hypernova," more powerful than a supernova, at the end of its normal life. The hypernova explosion, scientists believe, would come only a few million years after the giant star was formed, while it is still within the cloud of gas and dust from which it formed. Neutron stars, on the other hand, are formed by supernova explosions that give a "kick" to the resulting neutron star, propelling it at high speeds. An orbiting pair of neutron stars, astronomers think, would collide only after hundreds of millions of years of orbital decay, by which time they would be far away from the gas and dust of their birthplace. "The observations already have provided crucial insight; we intend to continue observing the relic of the March 29 burst with the VLA, and in the coming months, we will gain new information that will help further refine our ideas about these fireballs," Frail said. "We're going to learn about the size and expansion rate of the fireball and test predictions made by the models." "These observations indicate the extraordinary importance of radio astronomy for providing information that can be gained in no other way about one of the major frontier areas of astrophysics," said Hugh Van Horn, Director of the NSF's Division of Astronomical Sciences. The March 29 burst (GRB 980329) was the second such blast to have its afterglow detected at radio wavelengths. Last year, the VLA made the first radio detection of a GRB afterglow, finding radio emission coming from the location of a Gamma Ray Burst on May 8, 1997 (GRB 970508). "Of the world's radio telescopes, only the VLA has the sensitivity and resolving power to quickly detect these radio afterglows of Gamma Ray Bursts and study them in detail over extended periods of time," Taylor said. "Even so, we only see the brightest one-third of them. With upgraded capabilities at the VLA, as planned by NRAO, we will see them all." The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

Do the enigmatic ``Infrared-Faint Radio Sources'' include pulsars?

NASA Astrophysics Data System (ADS)

Hobbs, George; Middelberg, Enno; Norris, Ray; Keith, Michael; Mao, Minnie; Champion, David

2009-04-01

The Australia Telescope Large Area Survey (ATLAS) team have surveyed seven square degrees of sky at 1.4GHz. During processing some unexpected infrared-faint radio sources (IFRS sources) were discovered. The nature of these sources is not understood, but it is possible that some of these sources may be pulsars within our own galaxy. We propose to observe the IFRS sources with steep spectral indices using standard search techniques to determine whether or not they are pulsars. A pulsar detection would 1) remove a subset of the IFRS sources from the ATLAS sample so they would not need to be observed with large optical/IR telescopes to find their hosts and 2) be intrinsically interesting as the pulsar would be a millisecond pulsar and/or have an extreme spatial velocity.

OT1_mhuang01_1: GRB Afterglow Photometry with Herschel Infrared Cameras

NASA Astrophysics Data System (ADS)

Huang, M.

2010-07-01

GRB Afterglow Photometry with Herschel Infrared Cameras (GRAPHICS) Gamma-ray bursts (GRBs) are the most luminous explosions in the universe. It has been difficult to obtain a full spectral picture of the phenomena in the short period when GRBs become ``alive'', i.e. when they generate bursts in Gamma-ray and produce afterglows in other wavelengths. Between NIR (12micron) and submillimeter (850micron) there lies nearly two orders of magnitude of spectral range where GRB afterglows have never been detected. Herschel is unique in its cutting edge sensitivity, efficiency, and readiness in FIR observations, and is capable of detecting GRB afterglows. Observing GRB afterglows with Herschel would greatly enrich our understanding of GRB physics and conditions of the Universe in early epochs. We propose Target of Opportunity studies using the SPIRE and PACS instruments of Herschel to observe 3 bright GRB afterglows, each within a few hours to a few tens of days after burst. We will make follow-up observations after the initial one to photometrically measure GRB light curves and IR SEDs. We will make ground optical observations to compliment Herschel data, and have the the GRB community informed. Observing the forward shock peak in the FIR light curve and compare it (both the flux and time) with those in the optical and radio bands would give a unambiguous test to the fireball model, and offer a direct measurement of the density profile of the circumburst material. Catching the short-lived reverse shock emission and measure its magnitude would lead to constraints on some important parameters of the GRB ejecta and address the unknown composition of GRBs, baryonic vs. magnetic.

A recombined fusion protein PTD-Grb2-SH2 inhibits the proliferation of breast cancer cells in vitro.

PubMed

Yin, Jikai; Cai, Zhongliang; Zhang, Li; Zhang, Jian; He, Xianli; Du, Xilin; Wang, Qing; Lu, Jianguo

2013-03-01

The growth factor receptor bound protein 2 (Grb2) is one of the affirmative targets for cancer therapy, especially for breast cancer. In this study, we hypothesized the Src-homology 2 (SH2) domain in Grb2 may serve as a competitive protein-binding agent to interfere with the proliferation of breast cancer cells in vitro. We designed, constructed, expressed and purified a novel fusion protein containing the protein transduction domain (PTD) and Grb2-SH2 domain (we named it after PTD-Grb2-SH2). An immunofluorescence assay was used to investigate the location of PTD-Grb2-SH2 in cells. MTT assay and EdU experiments were applied to detect the proliferation of breast cancer cells. The ultra-structure was observed using transmission electron microscopy. Flow cytometry was used to determine the cytotoxicity of PTD-Grb2-SH2 on cell proliferation. We successfully obtained the PTD-Grb2-SH2 fusion protein in soluble form using a prokaryotic expression system. The new fusion protein successfully passed through both the cellular and nuclear membranes of breast cancer cells. The MTT assay showed that PTD-Grb2-SH2 exhibited significant toxicity to breast cancer cells in a dose- and time-dependent manner in vitro. EdU identified the decreased proliferation rates in treated MDA-MB-231 and SK-BR-3 cells. Observation by transmission electron microscopy and flow cytometry further confirmed the cytotoxicity as apoptosis. Our results show that the HIV1-TAT domain is a useful tool for transporting a low molecular weight protein across the cell membrane in vitro. The PTD-Grb2-SH2 may be a novel agent for breast cancer therapy.

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

NASA Astrophysics Data System (ADS)

Gunzburg, Menachem J.; Kulkarni, Ketav; Watson, Gabrielle M.; Ambaye, Nigus D.; Del Borgo, Mark P.; Brandt, Rebecca; Pero, Stephanie C.; Perlmutter, Patrick; Wilce, Matthew C. J.; Wilce, Jacqueline A.

2016-06-01

The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain. This revealed an unexpected binding mode of the peptide, in which the staple forms an alternative contact with the surface of the target protein. Based on this structural information, we designed a new series of bicyclic G7 peptides that progressively constrain the starting peptide, to arrive at the G7-B4 peptide that binds with an approximately 2-fold enhanced affinity to the Grb7-SH2 domain (KD = 0.83 μM) compared to G7-B1 and shows low affinity binding to Grb2-, Grb10- and Grb14-SH2 domains (KD > 100 μM). Furthermore, we determined the structure of the G7-B4 bicyclic peptide in complex with the Grb7-SH2 domain, both before and after ring closing metathesis to show that the closed staple is essential to the target interaction. The G7-B4 peptide represents an advance in the development of Grb7 inhibitors and is a classical example of structure aided inhibitor development.

Fermi-LAT observations of the gamma-ray burst GRB 130427A.

PubMed

Ackermann, M; Ajello, M; Asano, K; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Bechtol, K; Bellazzini, R; Bissaldi, E; Bonamente, E; Bregeon, J; Brigida, M; Bruel, P; Buehler, R; Burgess, J Michael; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Cecchi, C; Chaplin, V; Charles, E; Chekhtman, A; Cheung, C C; Chiang, J; Chiaro, G; Ciprini, S; Claus, R; Cleveland, W; Cohen-Tanugi, J; Collazzi, A; Cominsky, L R; Connaughton, V; Conrad, J; Cutini, S; D'Ammando, F; de Angelis, A; DeKlotz, M; de Palma, F; Dermer, C D; Desiante, R; Diekmann, A; Di Venere, L; Drell, P S; Drlica-Wagner, A; Favuzzi, C; Fegan, S J; Ferrara, E C; Finke, J; Fitzpatrick, G; Focke, W B; Franckowiak, A; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gehrels, N; Germani, S; Gibby, M; Giglietto, N; Giles, M; Giordano, F; Giroletti, M; Godfrey, G; Granot, J; Grenier, I A; Grove, J E; Gruber, D; Guiriec, S; Hadasch, D; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Horan, D; Hughes, R E; Inoue, Y; Jogler, T; Jóhannesson, G; Johnson, W N; Kawano, T; Knödlseder, J; Kocevski, D; Kuss, M; Lande, J; Larsson, S; Latronico, L; Longo, F; Loparco, F; Lovellette, M N; Lubrano, P; Mayer, M; Mazziotta, M N; McEnery, J E; Michelson, P F; Mizuno, T; Moiseev, A A; Monzani, M E; Moretti, E; Morselli, A; Moskalenko, I V; Murgia, S; Nemmen, R; Nuss, E; Ohno, M; Ohsugi, T; Okumura, A; Omodei, N; Orienti, M; Paneque, D; Pelassa, V; Perkins, J S; Pesce-Rollins, M; Petrosian, V; Piron, F; Pivato, G; Porter, T A; Racusin, J L; Rainò, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Ritz, S; Roth, M; Ryde, F; Sartori, A; Parkinson, P M Saz; Scargle, J D; Schulz, A; Sgrò, C; Siskind, E J; Sonbas, E; Spandre, G; Spinelli, P; Tajima, H; Takahashi, H; Thayer, J G; Thayer, J B; Thompson, D J; Tibaldo, L; Tinivella, M; Torres, D F; Tosti, G; Troja, E; Usher, T L; Vandenbroucke, J; Vasileiou, V; Vianello, G; Vitale, V; Winer, B L; Wood, K S; Yamazaki, R; Younes, G; Yu, H-F; Zhu, S J; Bhat, P N; Briggs, M S; Byrne, D; Foley, S; Goldstein, A; Jenke, P; Kippen, R M; Kouveliotou, C; McBreen, S; Meegan, C; Paciesas, W S; Preece, R; Rau, A; Tierney, D; van der Horst, A J; von Kienlin, A; Wilson-Hodge, C; Xiong, S; Cusumano, G; La Parola, V; Cummings, J R

2014-01-03

The observations of the exceptionally bright gamma-ray burst (GRB) 130427A by the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the nature of these unique astrophysical sources. GRB 130427A had the largest fluence, highest-energy photon (95 GeV), longest γ-ray duration (20 hours), and one of the largest isotropic energy releases ever observed from a GRB. Temporal and spectral analyses of GRB 130427A challenge the widely accepted model that the nonthermal high-energy emission in the afterglow phase of GRBs is synchrotron emission radiated by electrons accelerated at an external shock.

The First Unambiguous Electromagnetic Counterpart to a Gravitational-Wave Signal: GRB 170817A and GW170817

NASA Astrophysics Data System (ADS)

Goldstein, Adam

2018-01-01

On 2017 August 17 at 12:41:06 UTC the Fermi Gamma-ray Burst Monitor (GBM) detected and triggered on the short gamma-ray burst (GRB) 170817A. Approximately 2 s prior to this GRB, the LIGO gravitational-wave observatory triggered on a binary compact merger candidate associated with the GRB. This is the first unambiguous coincident observation of gravitational waves and electromagnetic radiation from a single astrophysical source and marks the start of gravitational-wave multi-messenger astronomy. We report the GBM observations and analysis of this short GRB and the joint science that results from this discovery.

Fermi-LAT Observations of the Gamma-Ray Burst GRB 130427A

DOE PAGES

Ackermann, M.; Ajello, M.; Asano, K.; ...

2013-11-21

The Large Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the nature of these unique astrophysical sources using the observations of the exceptionally bright gamma-ray burst (GRB) 130427A. We found that GRB 130427A had the largest fluence, highest-energy photon (95 GeV), longest γ-ray duration (20 hours), and one of the largest isotropic energy releases ever observed from a GRB. Temporal and spectral analyses of GRB 130427A challenge the widely accepted model that the nonthermal high-energy emission in the afterglow phase of GRBs is synchrotron emission radiated by electrons accelerated at an external shock.

Fermi-LAT Observations of the Gamma-Ray Burst GRB 130427A

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Asano, K.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.;

GRB 060614: a Fake Short Gamma-Ray Burst

NASA Astrophysics Data System (ADS)

Caito, L.; Bernardini, M. G.; Bianco, C. L.; Dainotti, M. G.; Guida, R.; Ruffini, R.

2008-05-01

The explosion of GRB 060614 produced a deep break in the GRB scenario and opened new horizons of investigation because it can't be traced back to any traditional scheme of classification. In fact, it has features both of long bursts and of short bursts and, above all, it is the first case of long duration near GRB without any bright Ib/c associated Supernova. We will show that, in our canonical GRB scenario [1], this ``anomalous'' situation finds a natural interpretation and allows us to discuss a possible variation to the traditional classification scheme, introducing the distinction between ``genuine'' and ``fake'' short bursts.

GRB 060614: a progress report

NASA Astrophysics Data System (ADS)

Caito, L.; Bernardini, M. G.; Bianco, C. L.; Dainotti, M. G.; Guida, R.; Ruffini, R.

2008-01-01

The explosion of GRB 060614, detected by the Swift satellite, produced a deep break in the GRB scenario opening new horizons of investigation, because it can't be traced back to any traditional scheme of classification. In fact, it manifests peculiarities both of long bursts and of short bursts. Above all, it is the first case of long duration near GRB without any bright Ib/c associated Supernova. We will show that, in our canonical GRB scenario ([l]), this ``anomalous'' situation finds a natural interpretation and allows us to discuss a possible variation to the traditional classification scheme, introducing the distinction between ``genuine'' and ``fake'' short bursts.

A Bulk Comptonization Model for the Prompt GRB Emission and its Relation to the Fermi GRB Spectra

NASA Technical Reports Server (NTRS)

Kazanas, Demosthenes

2010-01-01

We present a model in which the GRB prompt emission at E E(sub peak) is due to bulk Comptonization by the relativistic blast wave motion of either its own synchrotron photons of ambient photons of the stellar configuration that gave birth to the GRB. The bulk Comptonization process then induces the production of relativistic electrons of Lorentz factor equal to that of the blast wave through interactions with its ambient protons. The inverse compton emission of these electrons produces a power law component that extends to multi GeV energies in good agreement with the LAT GRB observations.

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.

PubMed

Ackermann, Jochen A; Radtke, Daniel; Maurberger, Anna; Winkler, Thomas H; Nitschke, Lars

2011-04-20

Grb2 is a ubiquitously expressed adaptor protein, which activates Ras and MAP kinases in growth factor receptor signalling, while in B-cell receptor (BCR) signalling this role is controversial. In B cell lines it was shown that Grb2 can inhibit BCR-induced Ca(2+) signalling. Nonetheless, the physiological role of Grb2 in primary B cells is still unknown. We generated a B-cell-specific Grb2-deficient mouse line, which had a severe reduction of mature follicular B cells in the periphery due to a differentiation block and decreased B-cell survival. Moreover, we found several changes in important signalling pathways: enhanced BCR-induced Ca(2+) signalling, alterations in mitogen-activated protein kinase activation patterns and strongly impaired Akt activation, the latter pointing towards a defect in PI3K signalling. Interestingly, B-cell-specific Grb2-deficient mice showed impaired IgG and B-cell memory responses, and impaired germinal centre formation. Thus, Grb2-dependent signalling pathways are crucial for lymphocyte differentiation processes, as well as for control of secondary humoral immune responses.

Probing the Nature of Short Swift Bursts via Deep INTEGRAL Monitoring of GRB 050925

NASA Technical Reports Server (NTRS)

Sakamoto, T.; Barbier, L.; Barthelmy, S. D.; Cummings, J. R.; Fenimore, E. E.; Gehrels, N.; Krimm, H. A.; Markwardt, C. B.; Palmer, D. M.; Parsons, A. M.;

MOA-2008-BLG-379Lb: A massive planet from a high magnification event with a faint source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suzuki, D.; Sumi, T.; Fukagawa, M.

2014-01-10

We report on the analysis of the high microlensing event MOA-2008-BLG-379, which has a strong microlensing anomaly at its peak due to a massive planet with a mass ratio of q = 6.9 × 10{sup –3}. Because the faint source star crosses the large resonant caustic, the planetary signal dominates the light curve. This is unusual for planetary microlensing events, and as a result, the planetary nature of this light curve was not immediately noticed. The planetary nature of the event was found when the Microlensing Observations in Astrophysics (MOA) Collaboration conducted a systematic study of binary microlensing events previouslymore » identified by the MOA alert system. We have conducted a Bayesian analysis based on a standard Galactic model to estimate the physical parameters of the lens system. This yields a host star mass of M{sub L}=3.3{sub −1.2}{sup +1.7} M{sub ⊙} orbited by a planet of mass m{sub P}=0.56{sub −0.27}{sup +0.24} M{sub Jup} at an orbital separation of a=3.3{sub −1.2}{sup +1.3} AU at a distance of D{sub L}=4.1{sub −1.9}{sup +1.7} kpc. The faint source magnitude of I {sub S} = 21.30 and relatively high lens-source relative proper motion of μ{sub rel} = 7.6 ± 1.6 mas yr{sup –1} imply that high angular resolution adaptive optics or Hubble Space Telescope observations are likely to be able to detect the source star, which would determine the masses and distance of the planet and its host star.« less

LFlGRB: Luminosity function of long gamma-ray bursts

NASA Astrophysics Data System (ADS)

Paul, Debdutta

2018-04-01

LFlGRB models the luminosity function (LF) of long Gamma Ray Bursts (lGRBs) by using a sample of Swift and Fermi lGRBs to re-derive the parameters of the Yonetoku correlation and self-consistently estimate pseudo-redshifts of all the bursts with unknown redshifts. The GRB formation rate is modeled as the product of the cosmic star formation rate and a GRB formation efficiency for a given stellar mass.

Fast-growing SMBHs in Fast-growing Galaxies, at High Redshifts: the Role of Major Mergers as Revealed by ALMA

NASA Astrophysics Data System (ADS)

Trakhtenbrot, Benny; Lira, Paulina; Netzer, Hagai; Cicone, Claudia; Maiolino, Roberto; Shemmer, Ohad

2017-11-01

We present a long-term, multi-wavelength project to understand the epoch of fastest growth of the most massive black holes by using a sample of 40 luminous quasars at z 4.8. These quasars have rather uniform properties, with typical accretion rates and black hole masses of L/L_Edd 0.7 and M_BH 10^9 M_sun. The sample consists of ``FIR-bright'' sources with a previous Herschel/SPIRE detection, suggesting SFR>1000 M_sun/yr, as well as of ``FIR-faint'' sources for which Herschel stacking analysis implies a typical SFR of 400 M_sun/yr. Six of the quasars have been observed by ALMA in [C II] 157.74 micron line emission and adjacent rest-frame 150 □micron continuum, to study the dusty cold ISM. ALMA detected companion, spectroscopically confirmed sub-mm galaxies (SMGs) for three sources – one FIR-bright and two FIR-faint. The companions are separated by 14-45 kpc from the quasar hosts, and we interpret them as major galaxy interactions. Our ALMA data therefore clearly support the idea that major mergers may be important drivers for rapid, early SMBH growth. However, the fact that not all high-SFR quasar hosts are accompanied by interacting SMGs, and their ordered gas kinematics observed by ALMA, suggest that other processes may be fueling these systems. Our analysis thus demonstrates the diversity of host galaxy properties and gas accretion mechanisms associated with early and rapid SMBH growth.

An Ordinary Short Gamma-Ray Burst with Extraordinary Implications: Fermi -GBM Detection of GRB 170817A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldstein, A.; Roberts, O. J.; Connaughton, V.

On 2017 August 17 at 12:41:06 UTC the Fermi Gamma-ray Burst Monitor (GBM) detected and triggered on the short gamma-ray burst (GRB) 170817A. Approximately 1.7 s prior to this GRB, the Laser Interferometer Gravitational-wave Observatory triggered on a binary compact merger candidate associated with the GRB. This is the first unambiguous coincident observation of gravitational waves and electromagnetic radiation from a single astrophysical source and marks the start of gravitational-wave multi-messenger astronomy. We report the GBM observations and analysis of this ordinary short GRB, which extraordinarily confirms that at least some short GRBs are produced by binary compact mergers.

An Ordinary Short Gamma-Ray Burst with Extraordinary Implications: Fermi-GBM Detection of GRB 170817A

NASA Astrophysics Data System (ADS)

Goldstein, A.; Veres, P.; Burns, E.; Briggs, M. S.; Hamburg, R.; Kocevski, D.; Wilson-Hodge, C. A.; Preece, R. D.; Poolakkil, S.; Roberts, O. J.; Hui, C. M.; Connaughton, V.; Racusin, J.; von Kienlin, A.; Dal Canton, T.; Christensen, N.; Littenberg, T.; Siellez, K.; Blackburn, L.; Broida, J.; Bissaldi, E.; Cleveland, W. H.; Gibby, M. H.; Giles, M. M.; Kippen, R. M.; McBreen, S.; McEnery, J.; Meegan, C. A.; Paciesas, W. S.; Stanbro, M.

2017-10-01

On 2017 August 17 at 12:41:06 UTC the Fermi Gamma-ray Burst Monitor (GBM) detected and triggered on the short gamma-ray burst (GRB) 170817A. Approximately 1.7 s prior to this GRB, the Laser Interferometer Gravitational-wave Observatory triggered on a binary compact merger candidate associated with the GRB. This is the first unambiguous coincident observation of gravitational waves and electromagnetic radiation from a single astrophysical source and marks the start of gravitational-wave multi-messenger astronomy. We report the GBM observations and analysis of this ordinary short GRB, which extraordinarily confirms that at least some short GRBs are produced by binary compact mergers.

The Swift Gamma-ray Burst Explorer: Early views into Black-hole Creation

NASA Technical Reports Server (NTRS)

Hill, Joe

2006-01-01

Swift has exceeded every pre-launch predicted advance in GRB science. It has discovered the farthest GRB ever seen and identified new GRBs at a rate of 100/year. It has also explored a brand new time interval in GRB light curves by revealing unpredicted phenomena of GRB flares and rapid x-ray afterglow declines. Swift has conducted 20,00o successful slews to sources and is predicted to stay in orbit until 2022.

Modeling the Multiband Afterglows of GRB 060614 and GRB 060908: Further Evidence for a Double Power-law Hard Electron Energy Spectrum

NASA Astrophysics Data System (ADS)

Zhang, Q.; Xiong, S. L.; Song, L. M.

2018-04-01

Electrons accelerated in relativistic collisionless shocks are usually assumed to follow a power-law energy distribution with an index of p. Observationally, although most gamma-ray bursts (GRBs) have afterglows that are consistent with p > 2, there are still a few GRBs suggestive of a hard (p < 2) electron energy spectrum. Our previous work showed that GRB 091127 gave strong evidence for a double power-law hard electron energy (DPLH) spectrum with 1 < p 1 < 2, p 2 > 2 and an “injection break” assumed as γ b ∝ γ q in the highly relativistic regime, where γ is the bulk Lorentz factor of the jet. In this paper, we show that GRB 060614 and GRB 060908 provide further evidence for such a DPLH spectrum. We interpret the multiband afterglow of GRB 060614 with the DPLH model in a homogeneous interstellar medium by taking into account a continuous energy injection process, while, for GRB 060908, a wind-like circumburst density profile is used. The two bursts, along with GRB 091127, suggest a similar behavior in the evolution of the injection break, with q ∼ 0.5. Whether this represents a universal law of the injection break remains uncertain and more afterglow observations such as these are needed to test this conjecture.

Globular clusters in high-redshift dwarf galaxies: a case study from the Local Group

NASA Astrophysics Data System (ADS)

Zick, Tom O.; Weisz, Daniel R.; Boylan-Kolchin, Michael

2018-06-01

We present the reconstructed evolution of rest-frame ultraviolet (UV) luminosities of the most massive Milky Way dwarf spheroidal satellite galaxy, Fornax, and its five globular clusters (GCs) across redshift, based on analysis of the stellar fossil record and stellar population synthesis modelling. We find that (1) Fornax's (proto-)GCs can generate 10-100 times more UV flux than the field population, despite comprising <˜{5} per cent of the stellar mass at the relevant redshifts; (2) due to their respective surface brightnesses, it is more likely that faint, compact sources in the Hubble Frontier Fields (HFFs) are GCs hosted by faint galaxies, than faint galaxies themselves. This may significantly complicate the construction of a galaxy UV luminosity function at z > 3. (3) GC formation can introduce order-of-magnitude errors in abundance matching. We also find that some compact HFF objects are consistent with the reconstructed properties of Fornax's GCs at the same redshifts (e.g. surface brightness, star formation rate), suggesting we may have already detected proto-GCs in the early Universe. Finally, we discuss the prospects for improving the connections between local GCs and proto-GCs detected in the early Universe.

Isolation, characterization, and evaluation of multi-trait plant growth promoting rhizobacteria for their growth promoting and disease suppressing effects on ginger.

PubMed

Dinesh, Raghavan; Anandaraj, Muthuswamy; Kumar, Aundy; Bini, Yogiyar Kundil; Subila, Kizhakke Purayil; Aravind, Ravindran

2015-04-01

In this study, 100 PGPR strains isolated from different varieties of ginger (Zingiber officinale Rosc.) were first characterized for their morphological, biochemical, and nutrient mobilization traits in vitro. The PGPR were also screened in vitro for inhibition of Pythium myriotylum causing soft rot in ginger. Results revealed that only five PGPR showed >70% suppression of P. myriotylum. These 5 PGPR viz., GRB (Ginger rhizobacteria) 25--Burkholderia cepacia, GRB35--Bacillus amyloliquefaciens; GRB58--Serratia marcescens; GRB68--S. marcescens; GRB91--Pseudomonas aeruginosa were used for further growth promotion and biocontrol studies in the green house and field. The green house study revealed that GRB35 (B. amyloliquefaciens) and GRB68 (S. marcescens) registered markedly higher sprouting (96.3%) and lower disease incidence (48.1%) and greater rhizome yield (365.6 g pot(-1) and 384.4 g pot(-1), respectively), while control registered the lowest sprouting (66%), maximum soft rot incidence (100%) and lowest rhizome yield (134.4 g pot(-1)). In the field experiments also, GRB68 (S. marcescens) and GRB35 (B. amyloliquefaciens) registered the greatest sprouting (80% each), markedly lower soft rot incidence (5.2% and 7.3%, respectively) and higher yield (5.0 and 4.3 kg(3)m(-2), respectively) compared to chemicals like Streptomycin sulphate (73.0%, 18.5% and 2.3 kg(3)m(-2), respectively), Metalaxyl-Mancozeb (73.0%, 14.0% and 3.8 kg(3)m(-2), respectively) and control (73.0%, 25.1% and 2.2 kg 3m(-2), respectively). Overall, the results suggested that for growth promotion and management of soft rot disease in ginger, GRB35 B. amyloliquefaciens and GRB68 S. marcescens could be good alternatives to chemical measures. Since, the latter has been reported to be an opportunistic human pathogen, we recommend the use of B. amyloliquefaciens for integration into nutrient and disease management schedules for ginger cultivation. Copyright © 2015 Elsevier GmbH. All rights reserved.

A Missing-link in the Supernova-GRB Connection: The Case of SN 2012ap

NASA Astrophysics Data System (ADS)

Chakraborti, Sayan; Soderberg, Alicia; Chomiuk, Laura; Kamble, Atish; Yadav, Naveen; Ray, Alak; Hurley, Kevin; Margutti, Raffaella; Milisavljevic, Dan; Bietenholz, Michael; Brunthaler, Andreas; Pignata, Giuliano; Pian, Elena; Mazzali, Paolo; Fransson, Claes; Bartel, Norbert; Hamuy, Mario; Levesque, Emily; MacFadyen, Andrew; Dittmann, Jason; Krauss, Miriam; Briggs, M. S.; Connaughton, V.; Yamaoka, K.; Takahashi, T.; Ohno, M.; Fukazawa, Y.; Tashiro, M.; Terada, Y.; Murakami, T.; Goldsten, J.; Barthelmy, S.; Gehrels, N.; Cummings, J.; Krimm, H.; Palmer, D.; Golenetskii, S.; Aptekar, R.; Frederiks, D.; Svinkin, D.; Cline, T.; Mitrofanov, I. G.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Boynton, W.; Fellows, C.; Harshman, K.; Enos, H.; von Kienlin, A.; Rau, A.; Zhang, X.; Savchenko, V.

2015-06-01

Gamma-ray bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly, usually within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However, supernovae with heavy ejecta can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for a few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. However, the ejecta from SN 2009bb was baryon loaded and in nearly free expansion for a year, unlike GRBs. We report the first supernova discovered without a GRB but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. We discovered a bright and rapidly evolving radio counterpart driven by the circumstellar interaction of the relativistic ejecta. However, we did not find any coincident GRB with an isotropic fluence of more than one-sixth of the fluence from GRB 980425. This shows for the first time that central engines in SNe Ic, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.

The GRB All-sky Spectrometer Experiment I: Instrument Overview and Science Drivers

NASA Astrophysics Data System (ADS)

Martinot, Zachary; Voigt, Elana; Banks, Zachary; Pober, Jonathan; Morales, Miguel F.

2015-01-01

The GRB All-sky Spectrometer Experiment (GASE) is an experiment designed to detect low frequency highly dispersed radio emission in the afterglow of a GRB. The detection of such a signal could provide a probe of IGM density as well as the conditions near the source of a GRB. The instrument used is an eight-element array of dipole antennas located on the University of Washington campus. This poster will further elaborate the design of the instrument and its scientific goals.

MASTER: high amplitude OT and OT during Fermi inspection

NASA Astrophysics Data System (ADS)

Balanutsa, P.; Lipunov, V.; Rebolo, R.; Serra-Ricart, M.; Podesta, R.; Levato, H.; Buckley, D.; Gorbovskoy, E.; Tiurina, N.; Shumkov, V.; Gress, O.; Pogrosheva, T.; Kuznetsov, A.; Kornilov, V.; Chazov, V.; Vlasenko, D.; Vladimirov, V.; Gorbunov, I.; Krylov, A.; Lopez, C.; Podesta, F.; Saffe, C.; Gabovich, A.

2017-06-01

During trigger (short GRB)/ (GRB_TIME: 17/06/04 14:28:05.09 UT, GRB_RA,Dec(2000):22h 41m 46s,+40d 40' 12", GRB_ERROR: 4.10 [deg radius, statistical only] )inspection MASTER-Kislovodsk auto-detection system detected optical transient at (RA, Dec) = 23h 01m 48.65s +41d 19m 04.2s on 2017-06-04.97120 UT. The OT unfiltered magnitude is 19.2m (limit 19.3m).

SYNCHROTRON ORIGIN OF THE TYPICAL GRB BAND FUNCTION—A CASE STUDY OF GRB 130606B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Bin-Bin; Briggs, Michael S.; Uhm, Z. Lucas

2016-01-10

We perform a time-resolved spectral analysis of GRB 130606B within the framework of a fast-cooling synchrotron radiation model with magnetic field strength in the emission region decaying with time, as proposed by Uhm and Zhang. The data from all time intervals can be successfully fit by the model. The same data can be equally well fit by the empirical Band function with typical parameter values. Our results, which involve only minimal physical assumptions, offer one natural solution to the origin of the observed GRB spectra and imply that, at least some, if not all, Band-like GRB spectra with typical Bandmore » parameter values can indeed be explained by synchrotron radiation.« less

An origin for short gamma-ray bursts unassociated with current star formation.

PubMed

Barthelmy, S D; Chincarini, G; Burrows, D N; Gehrels, N; Covino, S; Moretti, A; Romano, P; O'Brien, P T; Sarazin, C L; Kouveliotou, C; Goad, M; Vaughan, S; Tagliaferri, G; Zhang, B; Antonelli, L A; Campana, S; Cummings, J R; D'Avanzo, P; Davies, M B; Giommi, P; Grupe, D; Kaneko, Y; Kennea, J A; King, A; Kobayashi, S; Melandri, A; Meszaros, P; Nousek, J A; Patel, S; Sakamoto, T; Wijers, R A M J

2005-12-15

Two short (< 2 s) gamma-ray bursts (GRBs) have recently been localized and fading afterglow counterparts detected. The combination of these two results left unclear the nature of the host galaxies of the bursts, because one was a star-forming dwarf, while the other was probably an elliptical galaxy. Here we report the X-ray localization of a short burst (GRB 050724) with unusual gamma-ray and X-ray properties. The X-ray afterglow lies off the centre of an elliptical galaxy at a redshift of z = 0.258 (ref. 5), coincident with the position determined by ground-based optical and radio observations. The low level of star formation typical for elliptical galaxies makes it unlikely that the burst originated in a supernova explosion. A supernova origin was also ruled out for GRB 050709 (refs 3, 31), even though that burst took place in a galaxy with current star formation. The isotropic energy for the short bursts is 2-3 orders of magnitude lower than that for the long bursts. Our results therefore suggest that an alternative source of bursts--the coalescence of binary systems of neutron stars or a neutron star-black hole pair--are the progenitors of short bursts.

The structure of the ISM in the Zone of Avoidance by high-resolution multi-wavelength observations

NASA Astrophysics Data System (ADS)

Tóth, L. V.; Doi, Y.; Pinter, S.; Kovács, T.; Zahorecz, S.; Bagoly, Z.; Balázs, L. G.; Horvath, I.; Racz, I. I.; Onishi, T.

2018-05-01

We estimate the column density of the Galactic foreground interstellar medium (GFISM) in the direction of extragalactic sources. All-sky AKARI FIS infrared sky survey data might be used to trace the GFISM with a resolution of 2 arcminutes. The AKARI based GFISM hydrogen column density estimates are compared with similar quantities based on HI 21cm measurements of various resolution and of Planck results. High spatial resolution observations of the GFISM may be important recalculating the physical parameters of gamma-ray burst (GRB) host galaxies using the updated foreground parameters.

A γ-ray burst at a redshift of z~8.2

NASA Astrophysics Data System (ADS)

Tanvir, N. R.; Fox, D. B.; Levan, A. J.; Berger, E.; Wiersema, K.; Fynbo, J. P. U.; Cucchiara, A.; Krühler, T.; Gehrels, N.; Bloom, J. S.; Greiner, J.; Evans, P. A.; Rol, E.; Olivares, F.; Hjorth, J.; Jakobsson, P.; Farihi, J.; Willingale, R.; Starling, R. L. C.; Cenko, S. B.; Perley, D.; Maund, J. R.; Duke, J.; Wijers, R. A. M. J.; Adamson, A. J.; Allan, A.; Bremer, M. N.; Burrows, D. N.; Castro-Tirado, A. J.; Cavanagh, B.; de Ugarte Postigo, A.; Dopita, M. A.; Fatkhullin, T. A.; Fruchter, A. S.; Foley, R. J.; Gorosabel, J.; Kennea, J.; Kerr, T.; Klose, S.; Krimm, H. A.; Komarova, V. N.; Kulkarni, S. R.; Moskvitin, A. S.; Mundell, C. G.; Naylor, T.; Page, K.; Penprase, B. E.; Perri, M.; Podsiadlowski, P.; Roth, K.; Rutledge, R. E.; Sakamoto, T.; Schady, P.; Schmidt, B. P.; Soderberg, A. M.; Sollerman, J.; Stephens, A. W.; Stratta, G.; Ukwatta, T. N.; Watson, D.; Westra, E.; Wold, T.; Wolf, C.

2009-10-01

Long-duration γ-ray bursts (GRBs) are thought to result from the explosions of certain massive stars, and some are bright enough that they should be observable out to redshifts of z>20 using current technology. Hitherto, the highest redshift measured for any object was z = 6.96, for a Lyman-α emitting galaxy. Here we report that GRB090423 lies at a redshift of z~8.2, implying that massive stars were being produced and dying as GRBs ~630Myr after the Big Bang. The burst also pinpoints the location of its host galaxy.

A gamma-ray burst at a redshift of z approximately 8.2.

PubMed

Tanvir, N R; Fox, D B; Levan, A J; Berger, E; Wiersema, K; Fynbo, J P U; Cucchiara, A; Krühler, T; Gehrels, N; Bloom, J S; Greiner, J; Evans, P A; Rol, E; Olivares, F; Hjorth, J; Jakobsson, P; Farihi, J; Willingale, R; Starling, R L C; Cenko, S B; Perley, D; Maund, J R; Duke, J; Wijers, R A M J; Adamson, A J; Allan, A; Bremer, M N; Burrows, D N; Castro-Tirado, A J; Cavanagh, B; de Ugarte Postigo, A; Dopita, M A; Fatkhullin, T A; Fruchter, A S; Foley, R J; Gorosabel, J; Kennea, J; Kerr, T; Klose, S; Krimm, H A; Komarova, V N; Kulkarni, S R; Moskvitin, A S; Mundell, C G; Naylor, T; Page, K; Penprase, B E; Perri, M; Podsiadlowski, P; Roth, K; Rutledge, R E; Sakamoto, T; Schady, P; Schmidt, B P; Soderberg, A M; Sollerman, J; Stephens, A W; Stratta, G; Ukwatta, T N; Watson, D; Westra, E; Wold, T; Wolf, C

2009-10-29

Long-duration gamma-ray bursts (GRBs) are thought to result from the explosions of certain massive stars, and some are bright enough that they should be observable out to redshifts of z > 20 using current technology. Hitherto, the highest redshift measured for any object was z = 6.96, for a Lyman-alpha emitting galaxy. Here we report that GRB 090423 lies at a redshift of z approximately 8.2, implying that massive stars were being produced and dying as GRBs approximately 630 Myr after the Big Bang. The burst also pinpoints the location of its host galaxy.

Hypernovae: Observational aspects

NASA Astrophysics Data System (ADS)

Danziger, I. J.

2001-05-01

Following the discovery of a supernova SN 1998bw very probably associated with the γ-ray burst source GRB980425 the term ``hypernova'' has been re-defined to embrace SNe of high energy associated with GRB's. Here we discuss in some detail the observed and inferred properties of SN 1998bw and its relation to other previously observed SNe to which it may be related. A brief account is given of other relatively nearby SNe where a possible association with GRB's has been suggested ex post facto. There are also cases where less direct but suggestive evidence for a SN/GRB association has been adduced for well observed GRB events and their associated afterglow. These are also referred to. Our conclusion is that observationally we are still near the beginning of understanding which types of SNe give rise to GRB's and how frequently they occur. Nevertheless objects such as SN1998bw surely give rise to young supernova remnants with high velocity oxygen-enriched filaments. .

The association of GRB 060218 with a supernova and the evolution of the shock wave.

PubMed

Campana, S; Mangano, V; Blustin, A J; Brown, P; Burrows, D N; Chincarini, G; Cummings, J R; Cusumano, G; Della Valle, M; Malesani, D; Mészáros, P; Nousek, J A; Page, M; Sakamoto, T; Waxman, E; Zhang, B; Dai, Z G; Gehrels, N; Immler, S; Marshall, F E; Mason, K O; Moretti, A; O'Brien, P T; Osborne, J P; Page, K L; Romano, P; Roming, P W A; Tagliaferri, G; Cominsky, L R; Giommi, P; Godet, O; Kennea, J A; Krimm, H; Angelini, L; Barthelmy, S D; Boyd, P T; Palmer, D M; Wells, A A; White, N E

2006-08-31

Although the link between long gamma-ray bursts (GRBs) and supernovae has been established, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a gamma-ray burst emerges from the star's surface, nor how a GRB progenitor explodes. Here we report observations of the relatively nearby GRB 060218 (ref. 5) and its connection to supernova SN 2006aj (ref. 6). In addition to the classical non-thermal emission, GRB 060218 shows a thermal component in its X-ray spectrum, which cools and shifts into the optical/ultraviolet band as time passes. We interpret these features as arising from the break-out of a shock wave driven by a mildly relativistic shell into the dense wind surrounding the progenitor. We have caught a supernova in the act of exploding, directly observing the shock break-out, which indicates that the GRB progenitor was a Wolf-Rayet star.

Affinity chromatography for purification of the modular protein growth factor receptor-bound protein 2 and development of a screening test for growth factor receptor-bound protein 2 Src homology 3 domain inhibitor using peroxidase-linked ligand.

PubMed

Gril, B; Liu, W Q; Lenoir, C; Garbay, C; Vidal, M

2006-04-01

Growth factor receptor-bound protein 2 (Grb2) is an adapter protein involved in the Ras-dependent signaling pathway that plays an important role in human cancers initiated by oncogenic receptors. Grb2 is constituted by one Src homology 2 domain surrounded by two SH3 domains, and the inhibition of the interactions produced by these domains could provide an antitumor approach. In evaluating chemical libraries, to search for potential Grb2 inhibitors, it was necessary to elaborate a rapid test for their screening. We have developed, first, a batch method based on the use of an affinity column bearing a Grb2-SH3 peptide ligand to isolate highly purified Grb2. We subsequently describe a very rapid 96-well screening of inhibitors based on a simple competition between purified Grb2 and a peroxidase-coupled proline-rich peptide.

THE BLACK HOLE CENTRAL ENGINE FOR ULTRA-LONG GAMMA-RAY BURST 111209A AND ITS ASSOCIATED SUPERNOVA 2011KL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, He; You, Zhi-Qiang; Lei, Wei-Hua

Recently, the first association between an ultra-long gamma-ray burst (GRB) and a supernova was reported, i.e., GRB 111209A/SN 2011kl, enabling us to investigate the physics of central engines or even progenitors for ultra-long GRBs. In this paper, we inspect the broadband data of GRB 111209A/SN 2011kl. The late-time X-ray light curve exhibits a GRB 121027A-like fallback bump, suggesting a black hole (BH) central engine. We thus propose a collapsar model with fallback accretion for GRB 111209A/SN 2011kl. The required model parameters, such as the total mass and radius of the progenitor star, suggest that the progenitor of GRB 111209A ismore » more likely a Wolf–Rayet star instead of a blue supergiant, and the central engine of this ultra-long burst is a BH. The implications of our results are discussed.« less

Revealing Physical Activity of GRB Central Engine with Macronova/Kilonova Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Zhao-Qiang; Jin, Zhi-Ping; Liang, Yun-Feng

The modeling of Li-Paczyński macronova/kilonova signals gives a reasonable estimate on the neutron-rich material ejected during the neutron star mergers. Usually the accretion disk is more massive than the macronova ejecta, with which the efficiencies of converting the disk mass into prompt emission of three merger-driven GRBs can hence be directly constrained. Supposing the macronovae/kilonovae associated with GRB 050709, GRB 060614, and GRB 130603B arose from radioactive decay of the r -process material, the upper limit on energy conversion efficiencies are found to be as low as ∼10{sup −6}–10{sup −4}. Moreover, for all three events, neutrino annihilation is likely powerfulmore » enough to account for the brief gamma-ray flashes. Neutrino annihilation can also explain the “extended” emission lasting ∼100 s in GRB 050709, but does not work for the one in GRB 060614. These progresses demonstrate that the macronova can serve as a novel probe of the central engine activity.« less

First survey of Wolf-Rayet star populations over the full extension of nearby galaxies observed with CALIFA

NASA Astrophysics Data System (ADS)

Miralles-Caballero, D.; Díaz, A. I.; López-Sánchez, Á. R.; Rosales-Ortega, F. F.; Monreal-Ibero, A.; Pérez-Montero, E.; Kehrig, C.; García-Benito, R.; Sánchez, S. F.; Walcher, C. J.; Galbany, L.; Iglesias-Páramo, J.; Vílchez, J. M.; González Delgado, R. M.; van de Ven, G.; Barrera-Ballesteros, J.; Lyubenova, M.; Meidt, S.; Falcon-Barroso, J.; Mast, D.; Mendoza, M. A.; Califa Collaboration

2016-08-01

The search of extragalactic regions with conspicuous presence of Wolf-Rayet (WR) stars outside the Local Group is challenging task owing to the difficulty in detecting their faint spectral features. In this exploratory work, we develop a methodology to perform an automated search of WR signatures through a pixel-by-pixel analysis of integral field spectroscopy (IFS) data belonging to the Calar Alto Legacy Integral Field Area survey, CALIFA. This procedure has been applied to a sample of nearby galaxies spanning a wide range of physical, morphological, and environmental properties. This technique allowed us to build the first catalogue of regions rich in WR stars with spatially resolved information, and enabled us to study the properties of these complexes in a two-dimensional (2D) context. The detection technique is based on the identification of the blue WR bump (around He IIλ4686 Å, mainly associated with nitrogen-rich WR stars; WN) and the red WR bump (around C ivλ5808 Å, mainly associated with carbon-rich WR stars; WC) using a pixel-by-pixel analysis that maximizes the number of independent regions within a given galaxy. We identified 44 WR-rich regions with blue bumps distributed in 25 out of a total of 558 galaxies. The red WR bump was identified only in 5 of those regions. Most of the WR regions are located within one effective radius from the galaxy centre, and around one-third are located within ~1 kpc or less from the centre. We found that the majority of the galaxies hosting WR populations in our sample are involved in some kind of interaction process. Half of the host galaxies share some properties with gamma-ray burst (GRB) hosts where WR stars, such as potential candidates to the progenitors of GRBs, are found. We also compared the WR properties derived from the CALIFA data with stellar population synthesis models, and confirm that simple star models are generally not able to reproduce the observations. We conclude that other effects, such as binary star channel (which could extend theWR phase up to 10 Myr), fast rotation, or other physical processes that cause the loss of observed Lyman continuum photons, very likely affect the derived WR properties, and hence should be considered when modelling the evolution of massive stars. Based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).

Unusual Central Engine Activity in the Double Burst GRB 110709B

NASA Technical Reports Server (NTRS)

Zhang, Bin-Bin; Burrows, David N.; Zhang, Bing; Meszaros, Peter; Stratta, Giulia; D'Elia, Valerio; Frederiks, Dmitry; Golenetskii, S.; Cummings, Jay R.; Wang, Xiang-Yu;

Gamma-Ray Burst Afterglows with ALMA

NASA Astrophysics Data System (ADS)

Urata, Y.; Huang, K.; Takahashi, S.

2015-12-01

We present multi-wavelength observations including sub-millimeter follow-ups for two GRB afterglows. The rapid SMA and multi-wavelength observations for GRB120326A revealed their complex emissions as the synchrotron self-inverse Compton radiation from reverse shock. The observations including ALMA for GRB131030A also showed the significant X-ray excess from the standard forward shock synchrotron model. Based on these results, we also discuss further observations for (A) constraining of the mass of progenitor with polarization, (B) the first confirmation of GRB jet collimation, and (C) revealing the origin of optically dark GRBs.

Observation of X-ray lines from a gamma-ray burst (GRB991216): evidence of moving ejecta from the progenitor.

PubMed

Piro, L; Garmire, G; Garcia, M; Stratta, G; Costa, E; Feroci, M; Mészáros, P; Vietri, M; Bradt, H; Frail, D; Frontera, F; Halpern, J; Heise, J; Hurley, K; Kawai, N; Kippen, R M; Marshall, F; Murakami, T; Sokolov, V V; Takeshima, T; Yoshida, A

2000-11-03

We report on the discovery of two emission features observed in the x-ray spectrum of the afterglow of the gamma-ray burst (GRB) of 16 December 1999 by the Chandra X-ray Observatory. These features are identified with the Ly(alpha) line and the narrow recombination continuum by hydrogenic ions of iron at a redshift z = 1.00 +/- 0.02, providing an unambiguous measurement of the distance of a GRB. Line width and intensity imply that the progenitor of the GRB was a massive star system that ejected, before the GRB event, a quantity of iron approximately 0.01 of the mass of the sun at a velocity approximately 0.1 of the speed of light, probably by a supernova explosion.

The Discovery of an Evolving Dust Scattered X-ray Halo Around GRB 031203

NASA Technical Reports Server (NTRS)

Vaughan, S.; Willingale, R.; OBrien, P. T.; Osborne, J. P.; Reeves, J. N.; Levan, A. J.; Watson, M. G.; Tedds, J. A.; Watson, D.; Santos-Lleo, M.

2003-01-01

We report the first detection of a time-dependent, dust-scattered X-ray halo around a gamma-ray burst. GRB3 031203 was observed by XMM-Newton starting six hours after the burst. The halo appeared as concentric ring-like structures centered on the GRB location. The radii of these structures increased with time as t(sup 1/2), consistent with small-angle X-ray scattering caused by a large column of dust along the line of sight to a cosmologically distant GRB. The rings are due to dust concentrated in two distinct slabs in the Galaxy located at distances of 880 and 1390 pc, consistent with known Galactic features. The halo brightness implies an initial soft X-ray pulse consistent with the observed GRB.

FERMI Observations of High-Energy Gamma-Ray Emission from GRB 080825C

DOE PAGES

Abdo, A. A.; Ackermann, M.; Asano, K.; ...

2009-11-24

The Fermi Gamma-ray Space Telescope has opened a new high-energy window in the study of gamma-ray bursts (GRBs). Here in this paper, we present a thorough analysis of GRB 080825C, which triggered the Fermi Gamma-ray Burst Monitor (GBM), and was the first firm detection of a GRB by the Fermi Large Area Telescope (LAT). We discuss the LAT event selections, background estimation, significance calculations, and localization for Fermi GRBs in general and GRB 080825C in particular. We show the results of temporal and time-resolved spectral analysis of the GBM and LAT data. Finally, we also present some theoretical interpretation ofmore » GRB 080825C observations as well as some common features observed in other LAT GRBs.« less

A MISSING-LINK IN THE SUPERNOVA–GRB CONNECTION: THE CASE OF SN 2012ap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborti, Sayan; Soderberg, Alicia; Kamble, Atish

2015-06-01

Gamma-ray bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly, usually within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However, supernovae with heavy ejecta can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for a few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. However, the ejecta from SN 2009bb was baryon loaded and in nearly free expansion formore » a year, unlike GRBs. We report the first supernova discovered without a GRB but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. We discovered a bright and rapidly evolving radio counterpart driven by the circumstellar interaction of the relativistic ejecta. However, we did not find any coincident GRB with an isotropic fluence of more than one-sixth of the fluence from GRB 980425. This shows for the first time that central engines in SNe Ic, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.« less

Radio observations of GRB 100418a: Test of an energy injection model explaining long-lasting GRB afterglows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moin, A.; Wang, Z.; Chandra, P.

We present the results of our radio observational campaign of gamma-ray burst (GRB) 100418a, for which we used the Australia Telescope Compact Array, the Very Large Array, and the Very Long Baseline Array. GRB 100418a was a peculiar GRB with unusual X-ray and optical afterglow profiles featuring a plateau phase with a very shallow rise. This observed plateau phase was believed to be due to a continued energy injection mechanism that powered the forward shock, giving rise to an unusual and long-lasting afterglow. The radio afterglow of GRB 100418a was detectable several weeks after the prompt emission. We conducted long-termmore » monitoring observations of the afterglow and attempted to test the energy injection model advocating that the continuous energy injection is due to shells of material moving at a wide range of Lorentz factors. We obtained an upper limit of γ < 7 for the expansion rate of the GRB 100418a radio afterglow, indicating that the range-of-Lorentz factor model could only be applicable for relatively slow-moving ejecta. A preferred explanation could be that continued activity of the central engine may have powered the long-lasting afterglow.« less

GRB 011121: A Collimated Outflow into Wind-Blown Surroundings

NASA Technical Reports Server (NTRS)

Greiner, J.; Klose, S.; Salvato, M.; Zeh, A.; Schwarz, R.; Hartmann, D. H.; Masetti, N.; Stecklum, B.; Lamer, G.; Lodieu, N.;

The Third Swift Burst Alert Telescope Gamma-Ray Burst Catalog

NASA Astrophysics Data System (ADS)

Lien, Amy; Sakamoto, Takanori; Barthelmy, Scott D.; Baumgartner, Wayne H.; Cannizzo, John K.; Chen, Kevin; Collins, Nicholas R.; Cummings, Jay R.; Gehrels, Neil; Krimm, Hans A.; Markwardt, Craig. B.; Palmer, David M.; Stamatikos, Michael; Troja, Eleonora; Ukwatta, T. N.

2016-09-01

To date, the Burst Alert Telescope (BAT) onboard Swift has detected ˜1000 gamma-ray bursts (GRBs), of which ˜360 GRBs have redshift measurements, ranging from z = 0.03 to z = 9.38. We present the analyses of the BAT-detected GRBs for the past ˜11 years up through GRB 151027B. We report summaries of both the temporal and spectral analyses of the GRB characteristics using event data (I.e., data for each photon within approximately 250 s before and 950 s after the BAT trigger time), and discuss the instrumental sensitivity and selection effects of GRB detections. We also explore the GRB properties with redshift when possible. The result summaries and data products are available at http://swift.gsfc.nasa.gov/results/batgrbcat/index.html. In addition, we perform searches for GRB emissions before or after the event data using the BAT survey data. We estimate the false detection rate to be only one false detection in this sample. There are 15 ultra-long GRBs (˜2% of the BAT GRBs) in this search with confirmed emission beyond ˜1000 s of event data, and only two GRBs (GRB 100316D and GRB 101024A) with detections in the survey data prior to the starting of event data.

THE THIRD SWIFT BURST ALERT TELESCOPE GAMMA-RAY BURST CATALOG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lien, Amy; Baumgartner, Wayne H.; Cannizzo, John K.

2016-09-20

To date, the Burst Alert Telescope (BAT) onboard Swift has detected ∼1000 gamma-ray bursts (GRBs), of which ∼360 GRBs have redshift measurements, ranging from z = 0.03 to z = 9.38. We present the analyses of the BAT-detected GRBs for the past ∼11 years up through GRB 151027B. We report summaries of both the temporal and spectral analyses of the GRB characteristics using event data (i.e., data for each photon within approximately 250 s before and 950 s after the BAT trigger time), and discuss the instrumental sensitivity and selection effects of GRB detections. We also explore the GRB propertiesmore » with redshift when possible. The result summaries and data products are available at http://swift.gsfc.nasa.gov/results/batgrbcat/index.html. In addition, we perform searches for GRB emissions before or after the event data using the BAT survey data. We estimate the false detection rate to be only one false detection in this sample. There are 15 ultra-long GRBs (∼2% of the BAT GRBs) in this search with confirmed emission beyond ∼1000 s of event data, and only two GRBs (GRB 100316D and GRB 101024A) with detections in the survey data prior to the starting of event data.« less

Structural properties of faint low surface brightness galaxies

NASA Astrophysics Data System (ADS)

Pahwa, Isha; Saha, Kanak

2018-05-01

We study the structural properties of Low Surface Brightness galaxies (LSB) using a sample of 263 galaxies observed by the Green Bank Telescope (Schneider et al. 1992). We perform 2D decompositions of these galaxies in the SDSS g, r and i bands using the GALFIT software. Our decomposition reveals that about 60% of these galaxies are bulgeless i.e., their light distributions are well modelled by pure exponential disks. The rest of the galaxies were fitted with two components: a Sersic bulge and an exponential disk. Most of these galaxies have bulge-to-total (B/T) ratio less than 0.1. However, of these 104 galaxies, 20% have B/T > 0.1 i.e., hosting significant bulge component and they are more prominent amongst the fainter LSBs. According to g - r colour criteria, most of the LSB galaxies in our sample are blue, with only 7 classified as red LSBs. About 15% of the LSB galaxies (including both blue and red) in our sample host stellar bars. The incidence of bars is more prominent in relatively massive blue LSB galaxies with very high gas fraction. These findings may provide important clues to the formation and evolution of LSB galaxies - in particular on the bar/bulge formation in faint LSB disks.

Compton echoes from nearby gamma-ray bursts

NASA Astrophysics Data System (ADS)

Beniamini, Paz; Giannios, Dimitrios; Younes, George; van der Horst, Alexander J.; Kouveliotou, Chryssa

2018-06-01

The recent discovery of gravitational waves from GW170817, associated with a short gamma-ray burst (GRB) at a distance of 40 Mpc, has demonstrated that short GRBs can occur locally and at a reasonable rate. Furthermore, gravitational waves enable us to detect close-by GRBs, even when we are observing at latitudes far from the jet's axis. We consider here Compton echoes, the scattered light from the prompt and afterglow emission. Compton echoes, an as yet undetected counterpart of GRBs, peak in X-rays and maintain a roughly constant flux for hundreds to thousands of years after the burst. Though too faint to be detected in typical cosmological GRBs, a fraction of close-by bursts with a sufficiently large energy output in X-rays, and for which the surrounding medium is sufficiently dense, may indeed be observed in this way. The detection of a Compton echo could provide unique insight into the burst properties and the environment's density structure. In particular, it could potentially determine whether or not there was a successful jet that broke through the compact binary merger ejecta. We discuss here the properties and expectations from Compton echoes and suggest methods for detectability.

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway.

PubMed

Tauchi, T; Boswell, H S; Leibowitz, D; Broxmeyer, H E

1994-01-01

Enforced expression of p210bcr-abl transforms interleukin 3 (IL-3)-dependent hematopoietic cell lines to growth factor-independent proliferation. It has been demonstrated that nonreceptor tyrosine kinase oncogenes may couple to the p21ras pathway to exert their transforming effect. In particular, p210bcr-abl was recently found to effect p21ras activation in hematopoietic cells. In this context, experiments were performed to evaluate a protein signaling pathway by which p210bcr-abl might regulate p21ras. It was asked whether Shc p46/p52, a protein containing a src-homology region 2 (SH2) domain, and known to function upstream from p21ras, might form specific complexes with p210bcr-abl and thus, possibly alter p21ras activity by coupling to the guanine nucleotide exchange factor (Sos/CDC25) through the Grb2 protein-Sos complex. This latter complex has been previously demonstrated to occur ubiquitously. We found that p210bcr-abl formed a specific complex with Shc and with Grb2 in three different murine cell lines transfected with a p210bcr-abl expression vector. There appeared to be a higher order complex containing Shc, Grb2, and bcr-abl proteins. In contrast to p210bcr-abl transformed cells, in which there was constitutive tight association between Grb2 and Shc, binding between Grb2 and Shc was Steel factor (SLF)-dependent in a SLF-responsive, nontransformed parental cell line. The SLF-dependent association between Grb2 and Shc in nontransformed cells involved formation of a complex of Grb2 with c-kit receptor after SLF treatment. Thus, p210bcr-abl appears to function in a hematopoietic p21ras activation pathway to allow growth factor-independent coupling between Grb2, which exists in a complex with the guanine nucleotide exchange factor (Sos), and p21ras. Shc may not be required for Grb2-c-kit interaction, because it fails to bind strongly to c-kit.

Probing the Cosmic Gamma-Ray Burst Rate with Trigger Simulations of the Swift Burst Alert Telescope

NASA Technical Reports Server (NTRS)

Lien, Amy; Sakamoto, Takanori; Gehrels, Neil; Palmer, David M.; Barthelmy, Scott D.; Graziani, Carlo; Cannizzo, John K.

2013-01-01

The gamma-ray burst (GRB) rate is essential for revealing the connection between GRBs, supernovae and stellar evolution. Additionally, the GRB rate at high redshift provides a strong probe of star formation history in the early universe. While hundreds of GRBs are observed by Swift, it remains difficult to determine the intrinsic GRB rate due to the complex trigger algorithm of Swift. Current studies of the GRB rate usually approximate the Swift trigger algorithm by a single detection threshold. However, unlike the previously own GRB instruments, Swift has over 500 trigger criteria based on photon count rate and additional image threshold for localization. To investigate possible systematic biases and explore the intrinsic GRB properties, we develop a program that is capable of simulating all the rate trigger criteria and mimicking the image threshold. Our simulations show that adopting the complex trigger algorithm of Swift increases the detection rate of dim bursts. As a result, our simulations suggest bursts need to be dimmer than previously expected to avoid over-producing the number of detections and to match with Swift observations. Moreover, our results indicate that these dim bursts are more likely to be high redshift events than low-luminosity GRBs. This would imply an even higher cosmic GRB rate at large redshifts than previous expectations based on star-formation rate measurements, unless other factors, such as the luminosity evolution, are taken into account. The GRB rate from our best result gives a total number of 4568 +825 -1429 GRBs per year that are beamed toward us in the whole universe.

Ginsenoside Rb1 inhibits autophagy through regulation of Rho/ROCK and PI3K/mTOR pathways in a pressure-overload heart failure rat model.

PubMed

Yang, Tianrui; Miao, Yunbo; Zhang, Tong; Mu, Ninghui; Ruan, Libo; Duan, Jinlan; Zhu, Ying; Zhang, Rongping

2018-06-01

This study was designed to explore the relationship between ginsenoside Rb1 (Grb1) and high-load heart failure (HF) in rats. The parameters of cardiac systolic function (left ventricular posterior wall thickness (LVPWT), left ventricular internal diastolic diameter (LVID), fraction shortening (FS) and mitral valves (MVs)) of rat hearts in each group were inspected by echocardiogram. The expressions of rat myocardial contractile proteins, autophagy-related proteins and the activation of Rho/ROCK and PI3K/mTOR pathways were detected by Western blot. LVPWT, FS, MVs and the expression of myocardial contractile proteins α-MHC, apoptosis-related proteins Bcl-2 and signalling pathway involved proteins pAkt and mTOR were significantly reduced in the HF, HF+5 mg/kg Grb1 (HF+Grb1-5) and HF+Grb1+arachidonic acid (AA) groups with LVID, β-MHC, cell apoptosis, cell autophagy and Rho/ROCK significantly increased compared with the control group, of which the tendency was contrary to the HF+20 mg/kg Grb1 (HF+Grb1-20) group compared with the HF group (P < 0.05). In the HF+Grb1+AA group, there was no significant change in the above indexes compared with the HF group. The results indicated that Grb1 can exert anti-HF function by inhibiting cardiomyocyte autophagy of rats through regulation of Rho/ROCK and PI3K/mTOR pathways. © 2018 Royal Pharmaceutical Society.

A Globular Cluster Luminosity Function Distance to NGC 4993 Hosting a Binary Neutron Star Merger GW170817/GRB 170817A

NASA Astrophysics Data System (ADS)

Lee, Myung Gyoon; Kang, Jisu; Im, Myungshin

2018-05-01

NGC 4993 hosts a binary neutron star merger, GW170817/GRB 170817A, emitting gravitational waves and electromagnetic waves. The distance to this galaxy is not well established. We select the globular cluster candidates from the Hubble Space Telescope (HST)/ACS F606W images of NGC 4993 in the archive, using the structural parameters of the detected sources. The radial number density distribution of these candidates shows a significant central concentration around the galaxy center at the galactocentric distance r < 50″, showing that they are mostly the members of NGC 4993. Also, the luminosity function of these candidates is fit well by a Gaussian function. Therefore, the selected candidates at r < 50″ are mostly considered to be globular clusters in NGC 4993. We derive an extinction-corrected turnover Vega magnitude in the luminosity function of the globular clusters at 20″ < r < 50″, F606W (max)0 = 25.36 ± 0.08 (V 0 = 25.52 ± 0.11) mag. Adopting the calibration of the turnover magnitudes of the globular clusters, M V (max) = ‑7.58 ± 0.11, we derive a distance to NGC 4993, d = 41.65 ± 3.00 Mpc ({(m-M)}0 = 33.10+/- 0.16). The systematic error of this method can be as large as ±0.3 mag. This value is consistent with the previous distance estimates based on the fundamental plane relation and the gravitational wave method in the literature. The distance in this study can be used to constrain the values of the parameters including the inclination angle of the binary system in the models of gravitational wave analysis.

Synchrotron radiation and diffusive shock acceleration - A short review and GRB perspective

NASA Astrophysics Data System (ADS)

Karlica, Mile

2015-12-01

In this talk we present the sponge" model and its possible implications on the GRB afterglow light curves. "Sponge" model describes source of GRB afterglow radiation as fragmented GRB ejecta where bubbles move through the rarefied medium. In the first part of the talk a short introduction to synchrotron radiation and Fermi acceleration was presented. In the assumption that X-ray luminosity of GRB afterglow phase comes from the kinetic energy losses of clouds in ejecta medium radiated as synchrotron radiation we solved currently very simple equation of motion to find which combination of cloud and medium regime describes the afterglow light curve the best. We proposed for the first step to watch simple combinations of expansion regimes for both bubbles and surrounding medium. The closest case to the numerical fit of GRB 150403A with time power law index k = 1.38 is the combination of constant bubbles and Sedov like expanding medium with time power law index k = 1.25. Of course the question of possible mixture of variuos regime combinations is still open within this model.

Optical polarimetric observations of GRB prompt emissions by MASTER robots-telescopes net.

NASA Astrophysics Data System (ADS)

Gorbovskoy, Evgeny; Lipunov, Vladimir; Kornilov, Victor; Shatskij, Nikolaj; Kuvshi-Nov, Dmitry; Tyurina, Nataly; Belinski, Alexander; Krylov, Alexander; Balanutsa, Pavel; Chazov, Vadim; Kuznetsov, Artem; Zimnuhov, Dmitry; Balanutsa, Pavel; Kortunov, Petr; Sankovich, Anatoly; Tlatov, An-Drey; Parkhomenko, A.; Krushinsky, Vadim; Zalozhnyh, Ivan; Popov, A.; Kopytova, Taisia; Ivanov, Kirill; Yazev, Sergey; Yurkov, Vladimir

The main goal of the MASTER-Net project is to produce a unique fast sky survey with all sky observed over a single night down to a limiting magnitude of 19 -20mag. Such a survey will make it possible to address a number of fundamental problems: search for dark energy via the discovery and photometry of supernovas (including SNIa), search for exoplanets, microlensing effects, discovery of minor bodies in the Solar System and space-junk monitoring. All MASTER telescopes can be guided by alerts, and we plan to observe prompt optical emission from gamma-ray bursts synchronously in several filters and in several polarization planes. Observations on telescopes capable to observ polarisation of GRB prompt emission have been begun in the summer of 2009. Since summer of 2009 an observations of several GRB have been made. In particular for GRB0910 and GRB091127 optical polarisation has been measured. So, for GRB091127 which supervision have begun all through 91 sec polarisation at level of several tens percent has been registered. (GCN 10231, GCN 10052, GCN 10203)

Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR

NASA Astrophysics Data System (ADS)

Ogura, Kenji; Okamura, Hideyasu

2013-10-01

Growth factor receptor-bound protein 2 (Grb2) is a small adapter protein composed of a single SH2 domain flanked by two SH3 domains. The N-terminal SH3 (nSH3) domain of Grb2 binds a proline-rich region present in the guanine nucleotide releasing factor, son of sevenless (Sos). Using NMR relaxation dispersion and chemical shift analysis methods, we investigated the conformational change of the Sos-derived proline-rich peptide during the transition between the free and Grb2 nSH3-bound states. The chemical shift analysis revealed that the peptide does not present a fully random conformation but has a relatively rigid structure. The relaxation dispersion analysis detected conformational exchange of several residues of the peptide upon binding to Grb2 nSH3.

A Unified Model for GRB Prompt Emission from Optical to Gamma-Rays; Exploring GRBs as Standard Candles

NASA Technical Reports Server (NTRS)

Guiriec, S.; Kouveliotou, C.; Hartmann, D. H.; Granot, J.; Asano, K.; Meszaros, P.; Gill, R.; Gehrels, N.; McEnery, J.

2016-01-01

The origin of prompt emission from gamma-ray bursts (GRBs) remains to be an open question. Correlated prompt optical and gamma-ray emission observed in a handful of GRBs strongly suggests a common emission region, but failure to adequately fit the broadband GRB spectrum prompted the hypothesis of different emission mechanisms for the low- and high-energy radiations. We demonstrate that our multi-component model for GRB -ray prompt emission provides an excellent fit to GRB 110205A from optical to gamma-ray energies. Our results show that the optical and highest gamma-ray emissions have the same spatial and spectral origin, which is different from the bulk of the X- and softest gamma-ray radiation. Finally, our accurate redshift estimate for GRB 110205A demonstrates promise for using GRBs as cosmological standard candles.

GRB 130427A: A Nearby Ordinary Monster

NASA Technical Reports Server (NTRS)

Maselli, A.; Melandri, A.; Nava, L.; Mundell, C. G.; Kawai, N.; Campana, S.; Covino, S.; Cummings, J. R.; Cusumano, G.; Evans, P. A.;

GRB 130427A: a nearby ordinary monster.

PubMed

Maselli, A; Melandri, A; Nava, L; Mundell, C G; Kawai, N; Campana, S; Covino, S; Cummings, J R; Cusumano, G; Evans, P A; Ghirlanda, G; Ghisellini, G; Guidorzi, C; Kobayashi, S; Kuin, P; La Parola, V; Mangano, V; Oates, S; Sakamoto, T; Serino, M; Virgili, F; Zhang, B-B; Barthelmy, S; Beardmore, A; Bernardini, M G; Bersier, D; Burrows, D; Calderone, G; Capalbi, M; Chiang, J; D'Avanzo, P; D'Elia, V; De Pasquale, M; Fugazza, D; Gehrels, N; Gomboc, A; Harrison, R; Hanayama, H; Japelj, J; Kennea, J; Kopac, D; Kouveliotou, C; Kuroda, D; Levan, A; Malesani, D; Marshall, F; Nousek, J; O'Brien, P; Osborne, J P; Pagani, C; Page, K L; Page, M; Perri, M; Pritchard, T; Romano, P; Saito, Y; Sbarufatti, B; Salvaterra, R; Steele, I; Tanvir, N; Vianello, G; Wiegand, B; Weigand, B; Wiersema, K; Yatsu, Y; Yoshii, T; Tagliaferri, G

2014-01-03

Long-duration gamma-ray bursts (GRBs) are an extremely rare outcome of the collapse of massive stars and are typically found in the distant universe. Because of its intrinsic luminosity (L ~ 3 × 10(53) ergs per second) and its relative proximity (z = 0.34), GRB 130427A reached the highest fluence observed in the γ-ray band. Here, we present a comprehensive multiwavelength view of GRB 130427A with Swift, the 2-meter Liverpool and Faulkes telescopes, and by other ground-based facilities, highlighting the evolution of the burst emission from the prompt to the afterglow phase. The properties of GRB 130427A are similar to those of the most luminous, high-redshift GRBs, suggesting that a common central engine is responsible for producing GRBs in both the contemporary and the early universe and over the full range of GRB isotropic energies.

Radioactive decay of the late-time light curves of GRB-SNe

NASA Astrophysics Data System (ADS)

Misra, Kuntal; Fruchte, Andrew Steven

2018-04-01

We present the late-time Hubble Space Telescope observations of two GRB associated supernovae, GRB 030329/SN 2003dh and XRF 060218/SN 2006aj. Using the multi-color data upto ˜ 320 days after the burst, we constrain the late-time decay nature of these supernovae. The decay rates of SN 2003dh are steeper than SN 2006aj. A comparison with two other GRB supernovae, GRB 980425/SN 1998bw and the supernova associated with XRF 020903, shows that the decay rates of SN 2003dh are similar to XRF 020903 and those of SN 2006aj are similar to SN 1998bw. The late-time decay rates are steeper than the 56Co?56Fe radioactive decay rate (0.0098 mag day-1) indicating that there is some leakage of gamma-rays.

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

PubMed

Levy-Apter, Einat; Finkelshtein, Eynat; Vemulapalli, Vidyasiri; Li, Shawn S-C; Bedford, Mark T; Elson, Ari

2014-12-26

The non-receptor isoform of protein-tyrosine phosphatase ϵ (cyt-PTPe) supports adhesion of bone-resorbing osteoclasts by activating Src downstream of integrins. Loss of cyt-PTPe reduces Src activity in osteoclasts, reduces resorption of mineralized matrix both in vivo and in cell culture, and induces mild osteopetrosis in young female PTPe KO mice. Activation of Src by cyt-PTPe is dependent upon this phosphatase undergoing phosphorylation at its C-terminal Tyr-638 by partially active Src. To understand how cyt-PTPe activates Src, we screened 73 Src homology 2 (SH2) domains for binding to Tyr(P)-638 of cyt-PTPe. The SH2 domain of GRB2 bound Tyr(P)-638 of cyt-PTPe most prominently, whereas the Src SH2 domain did not bind at all, suggesting that GRB2 may link PTPe with downstream molecules. Further studies indicated that GRB2 is required for activation of Src by cyt-PTPe in osteoclast-like cells (OCLs) in culture. Overexpression of GRB2 in OCLs increased activating phosphorylation of Src at Tyr-416 and of cyt-PTPe at Tyr-638; opposite results were obtained when GRB2 expression was reduced by shRNA or by gene inactivation. Phosphorylation of cyt-PTPe at Tyr-683 and its association with GRB2 are integrin-driven processes in OCLs, and cyt-PTPe undergoes autodephosphorylation at Tyr-683, thus limiting Src activation by integrins. Reduced GRB2 expression also reduced the ability of bone marrow precursors to differentiate into OCLs and reduced the fraction of OCLs in which podosomal adhesion structures assume organization typical of active, resorbing cells. We conclude that GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in OCLs. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yunda; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102; Xu, Guoxing

miR-411-5p (previously called miR-411) is severely involved in human diseases, however, the relationship between miR-411-5p and breast cancer has not been investigated thoroughly. Here, we found that the expression of miR-411-5p was downregulated in breast cancer tissues compared with their matched adjacent non-neoplastic tissues. In addition, the expression of miR-411-5p was also lower in breast cancer cell lines in contrast with MCF-10A. Moreover, we investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation. Ectopic expression of miR-411-5p suppressed the breast cancer cell proliferation, migration and invasionmore » while low expression of miR-411-5p exhibited the opposite effect. Furthermore, GRB2 was demonstrated to be significantly overexpressed in breast cancer tissues compared with normal tissues, and low expression of GRB2 had a longer overall survival compared with high expression of GRB2 in breast cancer. In general, our study shed light on the miR-411-5p related mechanism in the progression of breast cancer and, miR-411-5p/GRB2/Ras axis is potential to be molecular target for breast cancer therapy. - Highlights: • miR-411-5p is downregulated in breast cancer tissues and cell lines. • miR-411-5p inhibits breast cancer cells growth, migration and invasion in vitro. • GRB2 is a direct target of miR-411-5p in breast cancer. • GRB2 is overexpressed in breast cancer and associates with disease outcome. • miR-411-5p suppresses breast cancer progression though GRB2-SOS-Ras pathway.« less

Ginsenoside Rb1 ameliorates liver fat accumulation by upregulating perilipin expression in adipose tissue of db/db obese mice

PubMed Central

Yu, Xizhong; Ye, Lifang; Zhang, Hao; Zhao, Juan; Wang, Guoqiang; Guo, Chao; Shang, Wenbin

2014-01-01

Background Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts antidiabetic effects. We tested whether the insulin-sensitizing and antidiabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes. Methods Obese and diabetic db/db mice were treated with daily doses of 20 mg/kg G-Rb1 for 14 days. Hepatic fat accumulation was evaluated by measuring liver weight and triglyceride content. Levels of blood glucose and serum insulin were used to evaluate insulin sensitivity in db/db mice. Lipolysis in adipocytes was evaluated by measuring plasma-free fatty acids and glycerol release from 3T3-L1 adipocytes treated with G-Rb1. The expression of relevant genes was analyzed by western blotting, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay kit. Results G-Rb1 increased insulin sensitivity and alleviated hepatic fat accumulation in obese diabetic db/db mice, and these effects were accompanied by reduced liver weight and hepatic triglyceride content. Furthermore, G-Rb1 lowered the levels of free fatty acids in obese mice, which may contribute to a decline in hepatic lipid accumulation. Corresponding to these results, G-Rb1 significantly suppressed lipolysis in 3T3-L1 adipocytes and upregulated the perilipin expression in both 3T3-L1 adipocytes and mouse epididymal fat pads. Moreover, G-Rb1 increased the level of adiponectin and reduced that of tumor necrosis factor-α in obese mice, and these effects were confirmed in 3T3-L1 adipocytes. Conclusion G-Rb1 may improve insulin sensitivity in obese and diabetic db/db mice by reducing hepatic fat accumulation and suppressing adipocyte lipolysis; these effects may be mediated via the upregulation of perilipin expression in adipocytes. PMID:26199550

Gamma-ray Burst Cosmology

NASA Astrophysics Data System (ADS)

Wang, F. Y.

2011-07-01

Gamma-ray bursts (GRBs) are brief flashes of gamma-rays occurring at cosmological distances. GRB was discovered by Vela satellite in 1967. The discovery of afterglows in 1997 made it possible to measure the GRBs' redshifts and confirmed the cosmological origin. GRB cosmology includes utilizing long GRBs as standard candles to constrain the dark energy and cosmological parameters, measuring the high-redshift star formation rate (SFR), probing the metal enrichment history of the universe, dust, quantum gravity, etc. The correlations between GRB observables in the prompt emission and afterglow phases were discovered, so we can use these correlations as standard candles to constrain the cosmological parameters and dark energy, especially at high redshifts. Observations show that long GRBs may be associated with supernovae. So long GRBs are promising tools to measure the high-redshift SFR. GRB afterglows have a smooth continuum, so the extraction of IGM absorption features from the spectrum is very easy. The information of metal enrichment history and reionization can be obtained from the absorption lines. In this thesis, we investigate the high-redshift cosmology using GRBs, called GRB cosmology. This is a new and fast developing field. The structure of this thesis is as follows. In the first chapter, we introduce the progress of GRB studies. First we introduce the progress of GRB studies in various satellite eras, mainly in the Swift and Fermi eras. The fireball model and standard afterglow model are also presented. In chapter 2, we introduce the standard cosmology model, astronomical observations and dark energy models. Then progress on the GRB cosmology studies is introduced. Some of my works including what to be submitted are also introduced in this chapter. In chapter 3, we present our studies on constraining the cosmological parameters and dark energy using latest observations. We use SNe Ia, GRBs, CMB, BAO, the X-ray gas mass fraction in clusters and the linear growth rate of perturbations, and find that the ΛCDM is the best fitted model. The transition redshift z_{T} is from 0.40_{-0.08}^{+0.14} to 0.65_{-0.05}^{+0.10}. This is the first time to combine GRBs with other observations to constrain the cosmological parameters, dark energy and transition redshift. In chapter 4, we investigate the early dark energy model using GRBs, SNe Ia, CMB and BAO. The negligible dark energy at high redshift will influence the growth of cosmic structures and leave observable signatures that are different from the standard cosmology. We propose that GRBs are promising tools to study the early dark energy. We find that the fractional dark energy density is less than 0.03 and the linear growth index of perturbations is 0.66. In chapter 5, we use a model-independent method to constrain the dark energy equation of state (EOS) w(z). Among the parameters describing the properties of dark energy, EOS is the most important. Whether and how it evolves with time are crucial in distinguishing different cosmological models. In our analysis, we include high-redshift GRBs. We find that w(z)<0 at z>1.7, and EOS deviates from the cosmological constant at z>0.5 at 95.4% confidence level. In chapter 6, we probe the cosmographic parameters to distinguish between the dark energy and modified gravity models. These two families of models can drive the universe to acclerate. We first derive the expressions of deceleration, jerk and snap parameters in the dark energy and modified gravity models. The snap parameters in these models are different, so they can be used to distinguish between the models. In chapter 7, we measure the high-redshift SFR using long GRBs. Swift observations reveal that the number of high-redshift GRBs is larger than the predication from SFR. We find that the evolving initial mass function can interpret this discrepancy. We study the high-redshift SFR up to z˜ 8.2 considering the Swift GRBs tracing the star formation history and the cosmic metallicity evolution in different background cosmological models. In chapter 8, we present the observational signatures of Pop III GRBs and study the pre-galactic metal enrichment with the metal absorption lines in the GRB spectrum from first galaxy. We focus on the unusual circumburst environment inside the systems that hosted Pop III stars. The metals in the first galaxies produced by the first supernova explosion are likely to reside in the low-ionization states (C II, O I, Si II and Fe II). When GRB afterglow goes through the metal polluted region, the metal absorption lines may appear. The topology of metal enrichment could be highly inhomogeneous, so along different lines of sight, the metal absorption lines may show distinct signatures. A summary of the open questions in GRB cosmology filed is presented in chapter 9.

The 'Supercritical Pile' GRB Model: Afterglows and GRB, XRR, XRF Unification

NASA Technical Reports Server (NTRS)

Kazanas, D.

2007-01-01

We present the general notions and observational consequences of the "Supercritical Pile" GRB model; the fundamental feature of this model is a detailed process for the conversion of the energy stored in relativistic protons in the GRB Relativistic Blast Waves (RBW) into relativistic electrons and then into radiation. The conversion is effected through the $p \\, \\gamma \\rightarrow p \\, e circumflex + e circumflex -$ reaction, whose kinematic threshold is imprinted on the GRB spectra to provide a peak of their emitted luminosity at energy \\Ep $\\sim 1$ MeV in the lab frame. We extend this model to include, in addition to the (quasi--)thermal relativistic post-shock protons an accelerated component of power law form. This component guarantees the production of $e circumflex +e circumflex- - $pairs even after the RBW has slowed down to the point that its (quasi-) thermal protons cannot fulfill the threshold of the above reaction. We suggest that this last condition marks the transition from the prompt to the afterglow GRB phase. We also discuss conditions under which this transition is accompanied by a significant drop in the flux and could thus account for several puzzling, recent observations. Finally, we indicate that the same mechanism applied to the late stages of the GRB evolution leads to a decrease in \\Ep $\\propto \\Gamma circumflex 2(t)\\propto t circumflex {-3/4}$, a feature amenable to future observational tests.

CONSTRAINTS ON VERY HIGH ENERGY EMISSION FROM GRB 130427A

DOE PAGES

Aliu, E.; Aune, T.; Barnacka, A.; ...

2014-10-10

In this study, prompt emission from the very fluent and nearby (z = 0.34) gamma-ray burst GRB 130427A was detected by several orbiting telescopes and by ground-based, wide-field-of-view optical transient monitors. Apart from the intensity and proximity of this GRB, it is exceptional due to the extremely long-lived high-energy (100 MeV to 100 GeV) gamma-ray emission, which was detected by the Large Area Telescope on the Fermi Gamma-Ray Space Telescope for ~70 ks after the initial burst. The persistent, hard-spectrum, high-energy emission suggests that the highest-energy gamma rays may have been produced via synchrotron self-Compton processes though there is alsomore » evidence that the high-energy emission may instead be an extension of the synchrotron spectrum. VERITAS, a ground-based imaging atmospheric Cherenkov telescope array, began follow-up observations of GRB 130427A ~71 ks (~20 hr) after the onset of the burst. The GRB was not detected with VERITAS; however, the high elevation of the observations, coupled with the low redshift of the GRB, make VERITAS a very sensitive probe of the emission from GRB 130427A for E > 100 GeV. In conclusion, the non-detection and consequent upper limit derived place constraints on the synchrotron self-Compton model of high-energy gamma-ray emission from this burst.« less

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation

PubMed Central

Law, Che-Leung; Ewings, Maria K.; Chaudhary, Preet M.; Solow, Sasha A.; Yun, Theodore J.; Marshall, Aaron J.; Hood, Leroy; Clark, Edward A.

1999-01-01

Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain–containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL–SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells. PMID:10209041

An optical supernova associated with the X-ray flash XRF 060218.

PubMed

Pian, E; Mazzali, P A; Masetti, N; Ferrero, P; Klose, S; Palazzi, E; Ramirez-Ruiz, E; Woosley, S E; Kouveliotou, C; Deng, J; Filippenko, A V; Foley, R J; Fynbo, J P U; Kann, D A; Li, W; Hjorth, J; Nomoto, K; Patat, F; Sauer, D N; Sollerman, J; Vreeswijk, P M; Guenther, E W; Levan, A; O'Brien, P; Tanvir, N R; Wijers, R A M J; Dumas, C; Hainaut, O; Wong, D S; Baade, D; Wang, L; Amati, L; Cappellaro, E; Castro-Tirado, A J; Ellison, S; Frontera, F; Fruchter, A S; Greiner, J; Kawabata, K; Ledoux, C; Maeda, K; Møller, P; Nicastro, L; Rol, E; Starling, R

2006-08-31

Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae that are more luminous than average and that eject material at very high velocities. Less-luminous supernovae were not hitherto known to be associated with GRBs, and therefore GRB-supernovae were thought to be rare events. Whether X-ray flashes--analogues of GRBs, but with lower luminosities and fewer gamma-rays--can also be associated with supernovae, and whether they are intrinsically 'weak' events or typical GRBs viewed off the axis of the burst, is unclear. Here we report the optical discovery and follow-up observations of the type Ic supernova SN 2006aj associated with X-ray flash XRF 060218. Supernova 2006aj is intrinsically less luminous than the GRB-supernovae, but more luminous than many supernovae not accompanied by a GRB. The ejecta velocities derived from our spectra are intermediate between these two groups, which is consistent with the weakness of both the GRB output and the supernova radio flux. Our data, combined with radio and X-ray observations, suggest that XRF 060218 is an intrinsically weak and soft event, rather than a classical GRB observed off-axis. This extends the GRB-supernova connection to X-ray flashes and fainter supernovae, implying a common origin. Events such as XRF 060218 are probably more numerous than GRB-supernovae.

Maltose-Binding Protein Enhances Secretion of Recombinant Human Granzyme B Accompanied by In Vivo Processing of a Precursor MBP Fusion Protein

PubMed Central

Dälken, Benjamin; Jabulowsky, Robert A.; Oberoi, Pranav; Benhar, Itai; Wels, Winfried S.

2010-01-01

Background The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes. Expression of enzymatically active GrB in recombinant form is a prerequisite for functional analysis and application of GrB for therapeutic purposes. Methods and Findings We investigated the influence of bacterial maltose-binding protein (MBP) fused to GrB via a synthetic furin recognition motif on the expression of the MBP fusion protein also containing an N-terminal α-factor signal peptide in the yeast Pichia pastoris. MBP markedly enhanced the amount of GrB secreted into culture supernatant, which was not the case when GrB was fused to GST. MBP-GrB fusion protein was cleaved during secretion by an endogenous furin-like proteolytic activity in vivo, liberating enzymatically active GrB without the need of subsequent in vitro processing. Similar results were obtained upon expression of a recombinant fragment of the ErbB2/HER2 receptor protein or GST as MBP fusions. Conclusions Our results demonstrate that combination of MBP as a solubility enhancer with specific in vivo cleavage augments secretion of processed and functionally active proteins from yeast. This strategy may be generally applicable to improve folding and increase yields of recombinant proteins. PMID:21203542

CONSTRAINING THE GRB-MAGNETAR MODEL BY MEANS OF THE GALACTIC PULSAR POPULATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rea, N.; Gullón, M.; Pons, J. A.

2015-11-10

A large fraction of Gamma-ray bursts (GRBs) displays an X-ray plateau phase within <10{sup 5} s from the prompt emission, proposed to be powered by the spin-down energy of a rapidly spinning newly born magnetar. In this work we use the properties of the Galactic neutron star population to constrain the GRB-magnetar scenario. We re-analyze the X-ray plateaus of all Swift GRBs with known redshift, between 2005 January and 2014 August. From the derived initial magnetic field distribution for the possible magnetars left behind by the GRBs, we study the evolution and properties of a simulated GRB-magnetar population using numericalmore » simulations of magnetic field evolution, coupled with Monte Carlo simulations of Pulsar Population Synthesis in our Galaxy. We find that if the GRB X-ray plateaus are powered by the rotational energy of a newly formed magnetar, the current observational properties of the Galactic magnetar population are not compatible with being formed within the GRB scenario (regardless of the GRB type or rate at z = 0). Direct consequences would be that we should allow the existence of magnetars and “super-magnetars” having different progenitors, and that Type Ib/c SNe related to Long GRBs form systematically neutron stars with higher initial magnetic fields. We put an upper limit of ≤16 “super-magnetars” formed by a GRB in our Galaxy in the past Myr (at 99% c.l.). This limit is somewhat smaller than what is roughly expected from Long GRB rates, although the very large uncertainties do not allow us to draw strong conclusion in this respect.« less

α-Lipoic acid inhibits human lung cancer cell proliferation through Grb2-mediated EGFR downregulation.

PubMed

Yang, Lan; Wen, Ya; Lv, Guoqing; Lin, Yuntao; Tang, Junlong; Lu, Jingxiao; Zhang, Manqiao; Liu, Wen; Sun, Xiaojuan

2017-12-09

Alpha lipoic acid (α -LA) is a naturally occurring antioxidant and metabolic enzyme co-factor. Recently, α -LA has been reported to inhibit the growth of various cancer cells, but the precise signaling pathways that mediate the effects of α -LA on non-small cell lung cancer (NSCLC) development remain unclear. The CCK-8 assay was used to assess cell proliferation in NSCLC cell lines after α -LA treatment. The expression of growth factor receptor-bound protein 2 (Grb2), cyclin-dependent kinase (CDK)-2, CDK4, CDK6, Cyclin D3, Cyclin E1, Ras, c-Raf, epidermal growth factor receptor (EGFR), ERK1/2 and activated EGFR and ERK1/2 was evaluated by western blotting. Grb2 levels were restored in α-LA-treated cells by transfection of a plasmid carrying Grb2 and were reduced in NSCLC cells via specific siRNA-mediated knockdown. α -LA dramatically decreased NSCLC cell proliferation by downregulating Grb2; in contrast, Grb2 overexpression significantly prevented α-LA-induced decrease in cell growth in vitro. Western blot analysis indicated that α-LA decreased the levels of phospho-EGFR, CDK2/4/6, Cyclins D3 and E1, which are associated with the inhibition of G1/S-phase transition. Additional experiments indicated that Grb2 inhibition partially abolished EGF-induced phospho-EGFR and phospho-ERK1/2 activity. In addition, α-LA exerted greater inhibitory effects than gefitinib on NSCLC cells by preventing EGF-induced EGFR activation. For the first time, these findings provide the first evidence that α-LA inhibits cell proliferation through Grb2 by suppressing EGFR phosphorylation and that MAPK/ERK is involved in this pathway. Copyright © 2017. Published by Elsevier Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Getachew, Yonas, E-mail: yonas.getachew@utsouthwestern.edu; Cusimano, Frank A.; James, Laura P.

The role of the immune system, specifically NK, NKT and CD3 cells, in acetaminophen (APAP) induced liver injury remains inconsistently defined. In the present study, wild type (C57BL/6J) mice and granzyme B deficient (GrB −/−) mice were treated with acetaminophen to assess the role of the immune system in acute liver injury. Doses of acetaminophen that induced sub lethal liver injury in wild type mice unexpectedly produced fatal hepatotoxicity in granzyme B deficient (GrB −/−) mice. Analysis revealed that GrB −/− mice had an increased population of intrahepatic CD3 (+), CD4 (−), and CD8 (−) lymphocytes expressing the CD69 activationmore » marker and Fas ligand. Depletion of these cells in the GrB −/− and wild type mice made them less susceptible to APAP injury, while depletion of NK1.1 (+) cells or both CD4 (+) and CD8 (+) T cells failed to provide the same hepatoprotection. Transfer of the GrB −/− IHLs further exacerbated liver injury and increased mortality in wild type mice but not in LRP/LPR mice, lacking fas expression. Conclusions: Acetaminophen toxicity is enhanced by the presence of activated, FasL expressing intrahepatic CD3 (+), CD4 (−), CD8 (−), NK1.1 (−) T cells. Depletion of these cells from GrB −/− mice and wild type mice greatly reduces mortality and improves the course of liver injury recovery. - Highlights: • Intrahepatic lymphocytes (IHLs) from GrB −/− mice harbor activated DNT cells. • IHLs from GrB −/− mice exhibit enhanced Fas ligand expression. • Acetaminophen toxicity is enhanced by activated, FasL expressing DNT cells.« less

Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple-negative breast cancer.

PubMed

Sparano, Joseph A; Goldstein, Lori J; Childs, Barrett H; Shak, Steven; Brassard, Diana; Badve, Sunil; Baehner, Frederick L; Bugarini, Roberto; Rowley, Steve; Perez, Edith A; Shulman, Lawrence N; Martino, Silvana; Davidson, Nancy E; Kenny, Paraic A; Sledge, George W; Gray, Robert

2011-11-15

To conduct an exploratory analysis of the relationship between gene expression and recurrence in patients with operable triple-negative breast cancer (TNBC) treated with adjuvant doxorubicin-containing chemotherapy. RNA was extracted from archived tumor samples derived from 246 patients with stage I-III TNBC treated with adjuvant doxorubicin-containing chemotherapy, and was analyzed by quantitative reverse transcriptase PCR for a panel of 374 genes. The relationship between gene expression and recurrence was evaluated using weighted Cox proportional hazards model score tests. Growth factor receptor bound protein 7 (GRB7) was the only gene for which higher expression was significantly associated with increased recurrence in TNBC (Korn's adjusted P value = 0.04). In a Cox proportional hazards model adjusted for clinicopathologic features, higher GRB7 expression was associated with an increased recurrence risk (HR = 2.31; P = 0.04 using the median as the split). The 5-year recurrence rates were 10.5% [95% confidence intervals (CI), 7.8-14.1] in the low and 20.4% (95% CI, 16.5-25.0) in the high GRB7 groups. External validation in other datasets indicated that GRB7 expression was not prognostic in two adjuvant trials including variable systemic therapy, but in two other trials showed that high GBR7 expression was associated with resistance to neoadjuvant doxorubicin and taxane therapy. GRB7 was associated with an increased risk of recurrence in TNBC, suggesting that GRB7 or GRB7-dependent pathways may serve as potential biomarkers for therapeutic targets. Therapeutic targeting of one or more factors identified which function as interaction nodes or effectors should also be considered.

Relationship Between Quantitative GRB7 RNA Expression and Recurrence after Adjuvant Anthracycline Chemotherapy in Triple Negative Breast Cancer

PubMed Central

Sparano, Joseph A.; Goldstein, Lori J.; Childs, Barrett H.; Shak, Steven; Brassard, Diana; Badve, Sunil; Baehner, Frederick L.; Bugarini, Roberto; Rowley, Steve; Perez, Edith; Shulman, Lawrence N.; Martino, Silvana; Davidson, Nancy E.; Kenny, Paraic A.; Sledge, George W.; Gray, Robert

2012-01-01

Purpose To perform an exploratory analysis of the relationship between gene expression and recurrence in patients with operable triple negative breast cancer (TNBC) treated with adjuvant doxorubicin-containing chemotherapy. Experimental design RNA was extracted from archived tumor samples derived from 246 patients with stage I-III TNBC treated with adjuvant doxorubicin-containing chemotherapy, and was analyzed by quantitative RT-PCR for a panel of 374 genes. The relationship between gene expression and recurrence was evaluated using weighted Cox proportional hazards model score tests. Results GRB7 was the only gene for which higher expression was significantly associated with increased recurrence in TNBC (Korn’s adjusted p value=0.04). In a Cox proportional hazards model adjusted for clinicopathologic features, higher GRB7 expression was associated with an increased recurrence risk (HR 2.31, p=0.04 using the median as the split). The 5-year recurrence rates were 10.5% (95% confidence intervals [CI] 7.8%, 14.1%) in the low and 20.4% (95% CI 16.5%, 25.0%) in the high GRB7 groups. External validation in other datasets indicated that GRB7 expression was not prognostic in two adjuvant trials including variable systemic therapy, but in two other trials showed that high GBR7 expression was associated with resistance to neoadjuvant doxorubicin and taxane therapy. Conclusions GRB7 was associated with an increased risk of recurrence in TNBC, suggesting that GRB7 or GRB7-dependent pathways may serve as potential biomarkers for therapeutic targets. Therapeutic targeting of one or more factors identified which function as interaction nodes or effectors should also be considered. PMID:21933890

Probing the cosmic gamma-ray burst rate with trigger simulations of the swift burst alert telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lien, Amy; Cannizzo, John K.; Sakamoto, Takanori

The gamma-ray burst (GRB) rate is essential for revealing the connection between GRBs, supernovae, and stellar evolution. Additionally, the GRB rate at high redshift provides a strong probe of star formation history in the early universe. While hundreds of GRBs are observed by Swift, it remains difficult to determine the intrinsic GRB rate due to the complex trigger algorithm of Swift. Current studies of the GRB rate usually approximate the Swift trigger algorithm by a single detection threshold. However, unlike the previously flown GRB instruments, Swift has over 500 trigger criteria based on photon count rate and an additional imagemore » threshold for localization. To investigate possible systematic biases and explore the intrinsic GRB properties, we develop a program that is capable of simulating all the rate trigger criteria and mimicking the image threshold. Our simulations show that adopting the complex trigger algorithm of Swift increases the detection rate of dim bursts. As a result, our simulations suggest that bursts need to be dimmer than previously expected to avoid overproducing the number of detections and to match with Swift observations. Moreover, our results indicate that these dim bursts are more likely to be high redshift events than low-luminosity GRBs. This would imply an even higher cosmic GRB rate at large redshifts than previous expectations based on star formation rate measurements, unless other factors, such as the luminosity evolution, are taken into account. The GRB rate from our best result gives a total number of 4568{sub −1429}{sup +825} GRBs per year that are beamed toward us in the whole universe.« less

A Central Role for GRB10 in Regulation of Islet Function in Man

PubMed Central

Prasad B, Rashmi; Salehi, S. Albert; Almgren, Peter; Osmark, Peter; Bouatia-Naji, Nabila; Wierup, Nils; Fall, Tove; Stančáková, Alena; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U.; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffrey R.; Blomstedt, Paul A.; Fadista, Joao; Alkayyali, Sami; Dayeh, Tasnim; Ahlqvist, Emma; Taneera, Jalal; Lecoeur, Cecile; Kumar, Ashish; Hansson, Ola; Hansson, Karin; Voight, Benjamin F.; Kang, Hyun Min; Levy-Marchal, Claire; Vatin, Vincent; Palotie, Aarno; Syvänen, Ann-Christine; Mari, Andrea; Weedon, Michael N.; Loos, Ruth J. F.; Ong, Ken K.; Nilsson, Peter; Isomaa, Bo; Tuomi, Tiinamaija; Wareham, Nicholas J.; Stumvoll, Michael; Widen, Elisabeth; Lakka, Timo A.; Langenberg, Claudia; Tönjes, Anke; Rauramaa, Rainer; Kuusisto, Johanna; Frayling, Timothy M.; Froguel, Philippe; Walker, Mark; Eriksson, Johan G.; Ling, Charlotte; Kovacs, Peter; Ingelsson, Erik; McCarthy, Mark I.; Shuldiner, Alan R.; Silver, Kristi D.; Laakso, Markku; Groop, Leif; Lyssenko, Valeriya

2014-01-01

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father. PMID:24699409

MONET: a MOnitoring NEtwork of Telescopes

NASA Astrophysics Data System (ADS)

Hessman, F. V.; Beuermann, K.

2002-01-01

MONET is a planned network of two 1m-class robotic telescopes which will be used for various photometric monitoring projects -- variable stars, planet searches, AGN's, GRB's -- as well as by school children in Germany and over the world. The two host partners, the Univ. of Texas' McDonald Observatory and the South African Astronomical Observatory, will operate the telescopes in exchange for observing time on the network. MONET will be one of the first robotic telescope networks offering 1-m class telescopes, complete coverage of the sky, good longitude coverage for long observing sequences on objects near the celestial equator, and a heavy educational emphasis.

Gamma Ray Bursts - Observations

NASA Technical Reports Server (NTRS)

Gehrels, N.; Cannizzo, J. K.

2010-01-01

We are in an exciting period of discovery for gamma-ray bursts. The Swift observatory is detecting 100 bursts per year, providing arcsecond localizations and sensitive observations of the prompt and afterglow emission. The Fermi observatory is observing 250 bursts per year with its medium-energy GRB instrument and about 10 bursts per year with its high-energy LAT instrument. In addition, rapid-response telescopes on the ground are providing new capabilities to study optical emission during the prompt phase and spectral signatures of the host galaxies. The combined data set is enabling great advances in our understanding of GRBs including afterglow physics, short burst origin, and high energy emission.

Afterglows and Kilonovae Associated with Nearby Low-luminosity Short-duration Gamma-Ray Bursts: Application to GW170817/GRB 170817A

NASA Astrophysics Data System (ADS)

Xiao, Di; Liu, Liang-Duan; Dai, Zi-Gao; Wu, Xue-Feng

2017-12-01

Very recently, the gravitational-wave (GW) event GW170817 was discovered to be associated with the short gamma-ray burst (GRB) 170817A. Multi-wavelength follow-up observations were carried out, and X-ray, optical, and radio counterparts to GW170817 were detected. The observations undoubtedly indicate that GRB 170817A originates from a binary neutron star merger. However, the GRB falls into the low-luminosity class that could have a higher statistical occurrence rate and detection probability than the normal (high-luminosity) class. This implies the possibility that GRB 170817A is intrinsically powerful, but we are off-axis and only observe its side emission. In this Letter, we provide a timely modeling of the multi-wavelength afterglow emission from this GRB and the associated kilonova signal from the merger ejecta, under the assumption of a structured jet, a two-component jet, and an intrinsically less-energetic quasi-isotropic fireball, respectively. Comparing the afterglow properties with the multi-wavelength follow-up observations, we can distinguish between these three models. Furthermore, a few model parameters (e.g., the ejecta mass and velocity) can be constrained.

GRB 110731A within the IGC paradigm

NASA Astrophysics Data System (ADS)

Primorac, Daria; Ruffini, Remo; Pisani, Giovanni Battista; Aimuratov, Yerlan; Biancol, Carlo Luciano; Karlica, Mile; Melon Fuksman, Julio David; Moradi, Rahim; Muccino, Marco; Penacchioni, Ana Virginia; Rueda, Jorge Armando; Wang, Yu

2018-01-01

Bright gamma-ray burst (GRB) 110731A was simultaneously observed by Fermi and Swift observatories, with a follow up optical observation which inferred the redshift of z = 2.83. Thus, available data are spanning from optical to high energy (GeV) emission. We analyze these data within the induced gravitational collapse (IGC) paradigm, recently introduced to explain temporal coincidence of some long GRBs with type Ic supernovae. The case of binary-driven hypcrnova (BdHN) assumes a close system, which starts as an evolved core - neutron star binary. After the core-collapse event, the new NS - black hole system is formed, emitting the GRB in the process. We performed the time-resolved and time-integrated analysis of the Fermi data. Preliminary results gave isotropic energy Eiso = 6.05 × 1053 erg and the total P-GRB energy of Ep-GRB = 3.7 × 1052 erg. At transparency point we found a Lorentz factor Γ 2.17 × 103 laboratory radius of 8.33 x 1013 cm, P-GRB observed temperature of 168 keV and a baryon load B = 4.35 × 10-4. Simulated light-curve and prompt emission spectra showed the average circum burst medium density to be n 0.03 particles per cm3. We reproduced the X-ray light-curve within the rest-frame of the source, finding the common late power-law behavior, with α = -1.22. Considering these results, we interpret GRB 110731A as a member of a BdHNe group.

RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes.

PubMed

Ganju, R K; Hatch, W C; Avraham, H; Ona, M A; Druker, B; Avraham, S; Groopman, J E

1997-03-17

The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has previously been reported to participate in signal transduction in neuronal cells, megakaryocytes, and B lymphocytes. We have found that RAFTK is constitutively expressed in human T cells and is rapidly phosphorylated upon the activation of the T cell receptor (TCR). This activation also results in an increase in the autophosphorylation and kinase activity of RAFTK. After its stimulation, there was an increase in the association of the src cytoplasmic tyrosine kinase Fyn and the adapter protein Grb2. This association was mediated through the SH2 domains of Fyn and Grb2. RAFTK also co-immunoprecipitates with the SH2 domain of Lck and with the cytoskeletal protein paxillin through its COOH-terminal proline-rich domain. The tyrosine phosphorylation of RAFTK after T cell receptor-mediated stimulation was reduced by the pretreatment of cells with cytochalasin D, suggesting the role of the cytoskeleton in this process. These observations indicate that RAFTK participates in T cell receptor signaling and may act to link signals from the cell surface to the cytoskeleton and thereby affect the host immune response.

On the nature of the extremely fast optical rebrightening of the afterglow of GRB 081029

NASA Astrophysics Data System (ADS)

Nardini, M.; Greiner, J.; Krühler, T.; Filgas, R.; Klose, S.; Afonso, P.; Clemens, C.; Guelbenzu, A. N.; Olivares E., F.; Rau, A.; Rossi, A.; Updike, A.; Küpcü Yoldaş, A.; Yoldaş, A.; Burlon, D.; Elliott, J.; Kann, D. A.

2011-07-01

Context. After the launch of the Swift satellite, the gamma-ray burst (GRB) optical light-curve smoothness paradigm has been questioned thanks to the faster and better sampled optical follow-up, which has unveiled a very complex behaviour. This complexity is triggering the interest of the whole GRB community. The GROND multi-channel imager is used to study optical and near-infrared (NIR) afterglows of GRBs with unprecedented optical and near-infrared temporal and spectral resolution. The GRB 081029 has a very prominent optical rebrightening event and is an outstanding example of the application of the multi-channel imager to GRB afterglows. Aims: Here we exploit the rich GROND multi-colour follow-up of GRB 081029 combined with XRT observations to study the nature of late-time rebrightenings that appear in the optical-NIR light-curves of some GRB afterglows. Methods: We analyse the optical and NIR observations obtained with the seven-channel Gamma-Ray burst Optical and Near-infrared Detector (GROND) at the 2.2 m MPI/ESO telescope and the X-ray data obtained with the XRT telescope on board the Swift observatory. The multi-wavelength temporal and spectral evolution is discussed in the framework of different physical models. Results: The extremely steep optical and NIR rebrightening observed in GRB 081029 cannot be explained in the framework of the standard forward shock afterglow model. The absence of a contemporaneous X-ray rebrightening and the evidence of a strong spectral evolution in the optical-NIR bands during the rise suggest two separate components that dominate in the early and late-time light-curves, respectively. The steepness of the optical rise cannot be explained even in the framework of the alternative scenarios proposed in the literature unless a late-time activity of the central engine is assumed. Full GROND photometry of GRB 081029 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/531/A39

Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome.

PubMed

Tan, Shan-Jun; Li, Ning; Zhou, Feng; Dong, Qian-Tong; Zhang, Xiao-Dong; Chen, Bi-Cheng; Yu, Zhen

2014-10-01

Postoperative fatigue syndrome (POFS) is a common clinical complication followed by almost every major abdominal surgery. Ginsenoside Rb1 (GRb1), a principle ginsenoside in ginseng, could exert a potent anti-fatigue effect on POFS. However, the mechanism is still unknown. Previous studies revealed that alterations in the energy metabolism in the skeletal muscle may play a vital role in the development and progression of fatigue. In the present study, we investigate the effect of GRb1 on energy metabolism in the skeletal muscle of a rat model of POFS induced by major small intestinal resection. GRb1 (10 mg/kg) was intraperitoneally administrated once daily for 1, 3, 7, and 10 d from the operation day, respectively. The locomotor activity was recorded every day, and total food intake was calculated starting from 24 h after surgery. After GRb1 treatment was completed, blood and skeletal muscle were sampled. The level of blood glucose was determined by an automatic biochemical analyzer. The content of adenosine triphosphate (ATP) in skeletal muscle was determined by high-performance liquid chromatography. The activity of energy metabolic enzymes Na(+)-K(+)-ATPase, pyruvate kinase, and succinate dehydrogenase (SDH) was assessed by commercially available kits. The results revealed that GRb1 could increase locomotor activity of POFS rats and significantly increase their total food intake postoperatively (P < 0.05). Furthermore, GRb1 also significantly increased ATP content in the skeletal muscle of POFS rats (P < 0.05). Meanwhile, the activity of Na(+)-K(+)-ATPase and SDH in the skeletal muscle of POFS rats was enhanced by GRb1 (P < 0.05). However, no significant differences in blood glucose and pyruvate kinase were found between the POFS and GRb1 treatment rats (P > 0.05). These results suggest that GRb1 may improve skeletal muscle energy metabolism in POFS, and the underlying mechanism may be associated with an increase in the content of ATP and an enhancement in the activity of energy metabolic enzymes such as Na(+)-K(+)-ATPase ATPase and SDH in the skeletal muscle. Copyright © 2014 Elsevier Inc. All rights reserved.

The Dark Side of Nature: the Crime was Almost Perfect

NASA Astrophysics Data System (ADS)

2006-12-01

Nature has again thrown astronomers for a loop. Just when they thought they understood how gamma-ray bursts formed, they have uncovered what appears to be evidence for a new kind of cosmic explosion. These seem to arise when a newly born black hole swallows most of the matter from its doomed parent star. Gamma-ray bursts (GRBs), the most powerful explosions in the Universe, signal the formation of a new black hole and come in two flavours, long and short ones. In recent years, international efforts have shown that long gamma-ray bursts are linked with the explosive deaths of massive stars (hypernovae; see e.g. ESO PR 16/03). ESO PR Photo 49a/06 ESO PR Photo 49a/06 GRB 060614 (FORS/VLT) Last year, observations by different teams - including the GRACE and MISTICI collaborations that use ESO's telescopes - of the afterglows of two short gamma-ray bursts provided the first conclusive evidence that this class of objects most likely originates from the collision of compact objects: neutron stars or black holes (see ESO PR 26/05 and ESO PR 32/05). The newly found gamma-ray bursts, however, do not fit the picture. They instead seem to share the properties of both the long and short classes. "Some unknown process must be at play, about which we have presently no clue," said Massimo Della Valle of the Osservatorio Astrofisico di Arcetri in Firenze, Italy, lead author of one of the reports published in this week's issue of the journal Nature. "Either it is a new kind of merger which is able to produce long bursts, or a new kind of stellar explosion in which matter can't escape the black hole." One of the mysterious events went bang on 14 June 2006, hence its name, GRB 060614. The gamma-ray burst lasted 102 seconds and belongs clearly to the category of long GRBs. As it happened in a relatively close-by galaxy, located only 1.6 billion light-years away in the constellation Indus, astronomers worldwide eagerly pointed their telescopes toward it to capture the supernova, watching and waiting as if for a jack-in-the-box to spring open. The MISTICI collaboration used ESO's Very Large Telescope to follow the burst for 50 days. "Despite our deep monitoring, no rebrightening due to a supernova was seen," said Gianpiero Tagliaferri from the Observatory of Brera, Italy and member of the team. "If a supernova is present, if should at least be 100 times fainter than any other supernova usually associated with a long burst." The burst exploded in a dwarf galaxy that shows moderate signs of star formation. Thus young, massive stars are present and, at the end of its life one of them could have uttered this long, agonising cry before vanishing into a black hole. "Why did it do so in a dark way, with no sign of a supernova?" asked Guido Chincarini, from the University of Milano-Bicocca, Italy, also member of the team. "A possibility is that a massive black hole formed that did not allow any matter to escape. All the material that is usually ejected in a supernova explosion would then fall back and be swallowed." ESO PR Photo 49c/06 ESO PR Photo 49b/06 GRB 060505 (FORS/VLT) The same conclusion was previously reached by another team, who monitored both GRB 060614 and another burst, GRB 060505 (5 May 2006) for 5 and 12 weeks, respectively. For this, they used the ESO VLT and the 1.54-m Danish telescope at La Silla. GRB 060505 was a faint burst with a duration of 4 seconds, and as such also belongs to the category of long bursts [1]. For GRB 060505, the astronomers could only see the burst in visible light for one night and then it faded away, while for GRB 060614, they could only follow it for four nights after the burst. Thus, if supernovae were associated with these long-bursts, as one would have expected, they must have been about a hundred times fainter than a normal supernova. "Although both bursts are long, the remarkable conclusion from our monitoring is that there were no supernovae associated with them," said Johan Fynbo from the DARK Cosmology Centre at the Niels Bohr Institute of the Copenhagen University in Denmark, who led the study. "It is a bit like not hearing the thunder from a nearby storm when one could see a very long lasting flash." For the May burst, the team has obtained deep images in very good observing conditions allowing the exact localisation of the burst in its host galaxy. The host galaxy turns out to be a small spiral galaxy, and the burst occurred in a compact star-forming region in one of the spiral arms of the galaxy. This is strong evidence that the star that made the GRB was massive [2]. "For the 5 May event, we have evidence that it was due to a massive star that died without making a supernova," said Fynbo. "We now have to find out what is the fraction of massive stars that die without us noticing, that is, without producing either a gamma-ray burst or a supernova." "Whatever the solution to the problem is, it is clear that these new results challenge the commonly accepted scenario, in which long bursts are associated with a bright supernova," said Daniele Malesani, from the International School for Advanced Studies in Trieste, and now also at the DARK Cosmology Centre. "Our hope is to be able to find more of these unconventional bursts. The chase is on!" High resolution images and their captions are available on the associated page. More information The two gamma-ray bursts were discovered with the NASA/ASI/PPARC Swift satellite, which is dedicated to the discovery of these powerful explosions. The work presented here is published in the 21 December 2006 issue of the journal Nature: "No supernovae associated with two long-duration gamma-ray bursts", by Johan P. U. Fynbo et al., and "An enigmatic long-lasting gamma-ray burst not accompanied by a bright supernova", by Massimo Della Valle et al. Two other reports about the same events are published in the same issue of Nature. The Italian-led team - the MISTICI collaboration - is composed of Massimo Della Valle (INAF, Osservatorio Astrofisico di Arcetri, Italy), Guido Chincarini (INAF, Osservatorio Astronomico di Brera & Università degli Studi di Milano-Bicocca, Italy), Nino Panagia (Space Telescope Science Institute, USA), Gianpiero Tagliaferri, Dino Fugazza, Sergio Campana, Stefano Covino, and Paolo D'Avanzo (INAF, Osservatorio Astronomico di Brera, Italy), Daniele Malesani (SISSA/ISAS, Italy and Dark Cosmology Centre, Copenhagen), Vincenzo Testa, L. Angelo Antonelli, Silvia Piranomonte, and Luigi Stella (INAF, Osservatorio Astronomico di Roma, Italy), Vanessa Mangano (INAF/IASF Palermo, Italy), Kevin Hurley (University of California, Berkeley, USA), I. Felix Mirabel (ESO), and Leonardo J. Pellizza (Instituto de Astronomia y Fisica del Espacio). The Danish-led team is composed of Johan P. U. Fynbo, Darach Watson, Christina C. Thöne, Tamara M. Davis, Jens Hjorth, José Mará Castro Cerón, Brian L. Jensen, Maximilian D. Stritzinger, and Dong Xu (Dark Cosmology Centre, University of Copenhagen, Denmark), Jesper Sollerman (Dark Cosmology Centre and Department of Astronomy, Stockholm University, Sweden), Uffe G. Jørgensen, Tobias C. Hinse, and Kristian G. Woller (Niels Bohr Institute, University of Copenhagen), Joshua S. Bloom, Daniel Kocevski, Daniel Perley (Department of Astronomy, University of California at Berkeley, USA), Páll Jakobsson (Centre for Astrophysics Research, University of Hertfordshire, UK), John F. Graham and Andrew S. Fruchter (Space Telescope Science Institute, Baltimore, USA), David Bersier (Astrophysics Research Institute, Liverpool John Moores University, UK), Lisa Kewley (University of Hawaii, Institute of Astronomy, USA), Arnaud Cassan and Marta Zub (Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg, Germany), Suzanne Foley (School of Physics, University College Dublin, Ireland), Javier Gorosabel (Instituto de Astrofisica de Andalucia, Granada, Spain), Keith D. Horne (SUPA Physics/Astronomy, University of St Andrews, Scotland, UK), Sylvio Klose (Thüringer Landessternwarte Tautenburg, Germany), Jean-Baptiste Marquette (Institut d'Astrophysique de Paris, France), Enrico Ramirez-Ruiz (Institute for Advanced Study, Princeton and Department of Astronomy and Astrophysics, University of California, Santa Cruz, USA), Paul M. Vreeswijk (ESO and Departamento de Astronomia, Universidad de Chile, Santiago, Chile), and Ralph A. M. Wijers (Astronomical Institute 'Anton Pannekoek', University of Amsterdam, The Netherlands).

Lyman-α emitters in the context of hierarchical galaxy formation: predictions for VLT/MUSE surveys

NASA Astrophysics Data System (ADS)

Garel, T.; Guiderdoni, B.; Blaizot, J.

2016-02-01

The VLT/Multi Unit Spectrograph Explorer (MUSE) integral-field spectrograph can detect Lyα emitters (LAE) in the redshift range 2.8 ≲ z ≲ 6.7 in a homogeneous way. Ongoing MUSE surveys will notably probe faint Lyα sources that are usually missed by current narrow-band surveys. We provide quantitative predictions for a typical wedding-cake observing strategy with MUSE based on mock catalogues generated with a semi-analytic model of galaxy formation coupled to numerical Lyα radiation transfer models in gas outflows. We expect ≈1500 bright LAEs (FLyα ≳ 10-17 erg s-1 cm-2) in a typical shallow field (SF) survey carried over ≈100 arcmin2 , and ≈2000 sources as faint as 10-18 erg s-1 cm-2 in a medium-deep field (MDF) survey over 10 arcmin2 . In a typical deep field (DF) survey of 1 arcmin2 , we predict that ≈500 extremely faint LAEs (FLyα ≳ 4 × 10-19 erg s-1 cm-2) will be found. Our results suggest that faint Lyα sources contribute significantly to the cosmic Lyα luminosity and SFR budget. While the host haloes of bright LAEs at z ≈ 3 and 6 have descendants with median masses of 2 × 1012 and 5 × 1013 M⊙, respectively, the faintest sources detectable by MUSE at these redshifts are predicted to reside in haloes which evolve into typical sub-L* and L* galaxy haloes at z = 0. We expect typical DF and MDF surveys to uncover the building blocks of Milky Way-like objects, even probing the bulk of the stellar mass content of LAEs located in their progenitor haloes at z ≈ 3.

A Different Point of View towards GRB 031203

NASA Technical Reports Server (NTRS)

Ramirez-Ruiz, E.; Granot, J.; Kouveliotou, C.; Woosley, S. E.; Patel, S. K.; Mazzali, P. A.

2004-01-01

One of the most fundamental characteristics of any explosion is its energy, yet despite lively debates, the gamma-ray burst (GRB) community has still to reach a consensus on whether GRBs are standard bombs with a total energy in their relativistic ejecta approximately 10(exp 51) ergs, or a broad range of phenomena with energies varying by many orders of magnitude. While low energy GRBs may well exist, we show here that observations of GRB 031203, do not require a sub-energetic nature for that event. In fact, contrary to previous claims, the data are more consistent with a typical, powerful GRB seen at an angle of about twice the opening angle of the central jet.

Linear Polarization, Circular Polarization, and Depolarization of Gamma-ray Bursts: A Simple Case of Jitter Radiation

NASA Astrophysics Data System (ADS)

Mao, Jirong; Wang, Jiancheng

2017-04-01

Linear and circular polarizations of gamma-ray bursts (GRBs) have been detected recently. We adopt a simplified model to investigate GRB polarization characteristics in this paper. A compressed two-dimensional turbulent slab containing stochastic magnetic fields is considered, and jitter radiation can produce the linear polarization under this special magnetic field topology. Turbulent Faraday rotation measure (RM) of this slab makes strong wavelength-dependent depolarization. The jitter photons can also scatter with those magnetic clumps inside the turbulent slab, and a nonzero variance of the Stokes parameter V can be generated. Furthermore, the linearly and circularly polarized photons in the optical and radio bands may suffer heavy absorptions from the slab. Thus we consider the polarized jitter radiation transfer processes. Finally, we compare our model results with the optical detections of GRB 091018, GRB 121024A, and GRB 131030A. We suggest simultaneous observations of GRB multi-wavelength polarization in the future.

An infrared flash contemporaneous with the gamma-rays of GRB 041219a.

PubMed

Blake, C H; Bloom, J S; Starr, D L; Falco, E E; Skrutskie, M; Fenimore, E E; Duchêne, G; Szentgyorgyi, A; Hornstein, S; Prochaska, J X; McCabe, C; Ghez, A; Konopacky, Q; Stapelfeldt, K; Hurley, K; Campbell, R; Kassis, M; Chaffee, F; Gehrels, N; Barthelmy, S; Cummings, J R; Hullinger, D; Krimm, H A; Markwardt, C B; Palmer, D; Parsons, A; McLean, K; Tueller, J

2005-05-12

The explosion that results in a cosmic gamma-ray burst (GRB) is thought to produce emission from two physical processes: the central engine gives rise to the high-energy emission of the burst through internal shocking, and the subsequent interaction of the flow with the external environment produces long-wavelength afterglows. Although observations of afterglows continue to refine our understanding of GRB progenitors and relativistic shocks, gamma-ray observations alone have not yielded a clear picture of the origin of the prompt emission nor details of the central engine. Only one concurrent visible-light transient has been found and it was associated with emission from an external shock. Here we report the discovery of infrared emission contemporaneous with a GRB, beginning 7.2 minutes after the onset of GRB 041219a (ref. 8). We acquired 21 images during the active phase of the burst, yielding early multi-colour observations. Our analysis of the initial infrared pulse suggests an origin consistent with internal shocks.

The Macronova in GRB 050709 and the GRB-macronova connection

PubMed Central

Jin, Zhi-Ping; Hotokezaka, Kenta; Li, Xiang; Tanaka, Masaomi; D'Avanzo, Paolo; Fan, Yi-Zhong; Covino, Stefano; Wei, Da-Ming; Piran, Tsvi

2016-01-01

GRB 050709 was the first short Gamma-ray Burst (sGRB) with an identified optical counterpart. Here we report a reanalysis of the publicly available data of this event and the discovery of a Li-Paczynski macronova/kilonova that dominates the optical/infrared signal at t>2.5 days. Such a signal would arise from 0.05 r-process material launched by a compact binary merger. The implied mass ejection supports the suggestion that compact binary mergers are significant and possibly main sites of heavy r-process nucleosynthesis. Furthermore, we have reanalysed all afterglow data from nearby short and hybrid GRBs (shGRBs). A statistical study of shGRB/macronova connection reveals that macronova may have taken place in all these GRBs, although the fraction as low as 0.18 cannot be ruled out. The identification of two of the three macronova candidates in the I-band implies a more promising detection prospect for ground-based surveys. PMID:27659791

Confronting GRB prompt emission with a model for subphotospheric dissipation

DOE PAGES

Ahlgren, Björn; Larsson, Josefin; Nymark, Tanja; ...

2015-09-16

The origin of the prompt emission in gamma-ray bursts (GRBs) is still an unsolved problem and several different mechanisms have been suggested. We fit Fermi GRB data with a photospheric emission model which includes dissipation of the jet kinetic energy below the photosphere. The resulting spectra are dominated by Comptonization and contain no significant contribution from synchrotron radiation. In order to fit to the data, we span a physically motivated part of the model's parameter space and create DREAM (Dissipation with Radiative Emission as A table Model), a table model for XSPEC. Here, we show that this model can describemore » different kinds of GRB spectra, including GRB 090618, representing a typical Band function spectrum, and GRB 100724B, illustrating a double peaked spectrum, previously fitted with a Band+blackbody model, suggesting they originate from a similar scenario. We also suggest that the main difference between these two types of bursts is the optical depth at the dissipation site.« less

Linear Polarization, Circular Polarization, and Depolarization of Gamma-ray Bursts: A Simple Case of Jitter Radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mao, Jirong; Wang, Jiancheng, E-mail: jirongmao@mail.ynao.ac.cn

Linear and circular polarizations of gamma-ray bursts (GRBs) have been detected recently. We adopt a simplified model to investigate GRB polarization characteristics in this paper. A compressed two-dimensional turbulent slab containing stochastic magnetic fields is considered, and jitter radiation can produce the linear polarization under this special magnetic field topology. Turbulent Faraday rotation measure (RM) of this slab makes strong wavelength-dependent depolarization. The jitter photons can also scatter with those magnetic clumps inside the turbulent slab, and a nonzero variance of the Stokes parameter V can be generated. Furthermore, the linearly and circularly polarized photons in the optical and radiomore » bands may suffer heavy absorptions from the slab. Thus we consider the polarized jitter radiation transfer processes. Finally, we compare our model results with the optical detections of GRB 091018, GRB 121024A, and GRB 131030A. We suggest simultaneous observations of GRB multi-wavelength polarization in the future.« less

A LUMINOUS, FAST RISING UV-TRANSIENT DISCOVERED BY ROTSE: A TIDAL DISRUPTION EVENT?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vinkó, J.; Wheeler, J. C.; Chatzopoulos, E.

2015-01-01

We present follow-up observations of an optical transient (OT) discovered by ROTSE on 2009 January 21. Photometric monitoring was carried out with ROTSE-IIIb in the optical and Swift in the UV up to +70 days after discovery. The light curve showed a fast rise time of ∼10 days followed by a steep decline over the next 60 days, which was much faster than that implied by {sup 56}Ni—{sup 56}Co radioactive decay. The Sloan Digital Sky Survey Data Release 10 database contains a faint, red object at the position of the OT, which appears slightly extended. This and other lines ofmore » evidence suggest that the OT is of extragalactic origin, and this faint object is likely the host galaxy. A sequence of optical spectra obtained with the 9.2 m Hobby-Eberly Telescope between +8 and +45 days after discovery revealed a hot, blue continuum with no visible spectral features. A few weak features that appeared after +30 days probably originated from the underlying host. Fitting synthetic templates to the observed spectrum of the host galaxy revealed a redshift of z = 0.19. At this redshift, the peak magnitude of the OT is close to –22.5, similar to the brightest super-luminous supernovae; however, the lack of identifiable spectral features makes the massive stellar death hypothesis less likely. A more plausible explanation appears to be the tidal disruption of a Sun-like star by the central supermassive black hole. We argue that this transient likely belongs to a class of super-Eddington tidal disruption events.« less

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.

PubMed

Schlaepfer, D D; Hanks, S K; Hunter, T; van der Geer, P

The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells attach to the extracellular matrix. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Here we show that adhesion of murine NIH3T3 fibroblasts to fibronectin promotes SH2-domain-mediated association of the GRB2 adaptor protein and the c-Src protein-tyrosine kinase (PTK) with FAK in vivo, and also results in activation of mitogen-activated protein kinase (MAPK). In v-Src-transformed NIH3T3, the association of v-Src, GRB2 and Sos with FAK is independent of cell adhesion to fibronectin. The GRB2 SH2 domain binds directly to tyrosine-phosphorylated FAK. Mutation of tyrosine residue 925 of FAK (YENV motif) to phenylalanine blocks GRB2 SH2-domain binding to FAK in vitro. Our results show that fibronectin binding to integrins on NIH3T3 fibroblasts promotes c-Src and FAK association and formation of an integrin-activated signalling complex. Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway.

The high-redshift gamma-ray burst GRB 140515A

DOE PAGES

Melandri, A.; Bernardini, M. G.; D'Avanzo, P. D.; ...

2015-09-09

High-redshift gamma-ray bursts (GRBs) offer several advantages when studying the distant Universe, providing unique information about the structure and properties of the galaxies in which they exploded. Spectroscopic identification with large ground-based telescopes has improved our knowledge of this kind of distant events. We present the multi-wavelength analysis of the high-zSwift GRB GRB 140515A (z = 6.327). The best estimate of the neutral hydrogen fraction of the intergalactic medium towards the burst is x HI ≤ 0.002. The spectral absorption lines detected for this event are the weakest lines ever observed in GRB afterglows, suggesting that GRB 140515A exploded inmore » a very low-density environment. Its circum-burst medium is characterised by an average extinction (AV ~ 0.1) that seems to be typical of z ≥ 6 events. The observed multi-band light curves are explained either with a very hard injected spectrum (p = 1.7) or with a multi-component emission (p = 2.1). In the second case a long-lasting central engine activity is needed in order to explain the late time X-ray emission. Furthermore, the possible origin of GRB 140515A in a Pop III (or in a Pop II star with a local environment enriched by Pop III) massive star is unlikely.« less

GRB 170817A as a jet counterpart to gravitational wave trigger GW 170817

NASA Astrophysics Data System (ADS)

Lamb, Gavin P.; Kobayashi, Shiho

2018-05-01

Fermi/GBM (Gamma-ray Burst Monitor) and INTEGRAL (the International Gamma-ray Astrophysics Laboratory) reported the detection of the γ-ray counterpart, GRB 170817A, to the LIGO (Light Interferometer Gravitational-wave Observatory)/Virgo gravitational wave detected binary neutron star merger, GW 170817. GRB 170817A is likely to have an internal jet or another origin such as cocoon emission, shock-breakout, or a flare from a viscous disc. In this paper we assume that the γ-ray emission is caused by energy dissipation within a relativistic jet and we model the afterglow synchrotron emission from a reverse- and forward-shock in the outflow. We show the afterglow for a low-luminosity γ-ray burst (GRB) jet with a high Lorentz-factor (Γ); a low-Γ and low-kinetic energy jet; a low-Γ, high kinetic energy jet; structured jets viewed at an inclination within the jet-half-opening angle; and an off-axis `typical' GRB jet. All jet models will produce observable afterglows on various timescales. The late-time afterglow from 10-110 days can be fit by a Gaussian structured jet viewed at a moderate inclination, however the GRB is not directly reproduced by this model. These jet afterglow models can be used for future GW detected NS merger counterparts with a jet afterglow origin.

Fusion protein based on Grb2-SH2 domain for cancer therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saito, Yuriko; Graduate School of Pharmaceutical Sciences, Chiba University; Furukawa, Takako, E-mail: tfuru@nirs.go.jp

2010-08-20

Research highlights: {yields} Grb2 mediates EGFR signaling through binding to phosphorylate EGFR with SH2 domain. {yields} We generated fusion proteins containing 1 or 2 SH2 domains of Grb2 added with TAT. {yields} The one with 2 SH2 domains (TSSF) interfered ERK phosphorylation. {yields} TSSF significantly delayed the growth of EGFR overexpressing tumor in a mouse model. -- Abstract: Epidermal growth factor receptor (EGFR) is one of the very attractive targets for cancer therapy. In this study, we generated fusion proteins containing one or two Src-homology 2 (SH2) domains of growth factor receptor bound protein 2 (Grb2), which bind to phosphorylatedmore » EGFR, added with HIV-1 transactivating transcription for cell membrane penetration (termed TSF and TSSF, respectively). We examined if they can interfere Grb2-mediated signaling pathway and suppress tumor growth as expected from the lack of SH3 domain, which is necessary to intermediate EGFR-Grb2 cell signaling, in the fusion proteins. The transduction efficiency of TSSF was similar to that of TSF, but the binding activity of TSSF to EGFR was higher than that of TSF. Treatment of EGFR-overexpressing cells showed that TSSF decreased p42-ERK phosphorylation, while TSF did not. Both the proteins delayed cell growth but did not induce cell death in culture. TSSF also significantly suppressed tumor growth in vivo under consecutive administration. In conclusion, TSSF showed an ability to inhibit EGFR-Grb2 signaling and could have a potential to treat EGFR-activated cancer.« less

GRB 140619B: a short GRB from a binary neutron star merger leading to black hole formation

NASA Astrophysics Data System (ADS)

Ruffini, R.; Muccino, M.; Kovacevic, M.; Oliveira, F. G.; Rueda, J. A.; Bianco, C. L.; Enderli, M.; Penacchioni, A. V.; Pisani, G. B.; Wang, Y.; Zaninoni, E.

2015-08-01

We show the existence of two families of short gamma-ray bursts (GRBs), both originating from the merger of binary neutron stars (NSs): family-1 with {E}{iso}\\lt {10}52 erg, leading to a massive NS as the merged core, and family-2 with {E}{iso}\\gt {10}52 erg, leading to a black hole (BH). Following the identification of the prototype GRB 090227B, we present the details of a new example of family-2 short burst: GRB 140619B. From the spectral analysis of the early ˜0.2 s, we infer an observed temperature {kT}=(324+/- 33) keV of the {{{e}}}+{{{e}}}--plasma at transparency (P-GRB), a theoretically derived redshift z=2.67+/- 0.37, a total burst energy {E}{{{e}}+{{{e}}}-}{tot}=(6.03+/- 0.79)× {10}52 erg, a rest-frame peak energy {E}p,i=4.7 MeV, and a baryon load B=(5.52+/- 0.73)× {10}-5. We also estimate the corresponding emission of gravitational waves. Two additional examples of family-2 short bursts are identified: GRB 081024B and GRB 090510, remarkable for its well determined cosmological distance. We show that marked differences exist in the nature of the afterglows of these two families of short bursts: family-2 bursts, leading to BH formation, consistently exhibit high energy emission following the proper-GRB emission; family-1 bursts, leading to the formation of a massive NS, should never exhibit high energy emission. We also show that both the families fulfill an {E}p,i-Eiso relation with slope γ =0.59+/- 0.07 and a normalization constant incompatible with the one for long GRBs. The observed rate of such family-2 events is {ρ }0=≤ft({2.1}-1.4+2.8\\right)× {10}-4 Gpc-3 yr-1.

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.

PubMed

Schlaepfer, D D; Hunter, T

1996-10-01

Focal adhesion kinase (FAK) is a nonreceptor protein-tyrosine kinase (PTK) that associates with integrin receptors and participates in extracellular matrix-mediated signal transduction events. We showed previously that the c-Src nonreceptor PTK and the Grb2 SH2/SH3 adaptor protein bound directly to FAK after fibronectin stimulation (D. D. Schlaepfer, S.K. Hanks, T. Hunter, and P. van der Geer, Nature [London] 372:786-791, 1994). Here, we present evidence that c-Src association with FAK is required for Grb2 binding to FAK. Using a tryptic phosphopeptide mapping approach, the in vivo phosphorylation of the Grb2 binding site on FAK (Tyr-925) was detected after fibronectin stimulation of NIH 3T3 cells and was constitutively phosphorylated in v-Src-transformed NIH 3T3 cells. In vitro, c-Src phosphorylated FAK Tyr-925 in a glutathione S-transferase-FAK C-terminal domain fusion protein, whereas FAK did not. Using epitope-tagged FAK constructs, transiently expressed in human 293 cells, we determined the effect of site-directed mutations on c-Src and Grb2 binding to FAK. Mutation of FAK Tyr-925 disrupted Grb2 binding, whereas mutation of the c-Src binding site on FAK (Tyr-397) disrupted both c-Src and Grb2 binding to FAK in vivo. These results support a model whereby Src-family PTKs are recruited to FAK and focal adhesions following integrin-induced autophosphorylation and exposure of FAK Tyr-397. Src-family binding and phosphorylation of FAK at Tyr-925 creates a Grb2 SH2-domain binding site and provides a link to the activation of the Ras signal transduction pathway. In Src-transformed cells, this pathway may be constitutively activated as a result of FAK Tyr-925 phosphorylation in the absence of integrin stimulation.

Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A

DOE PAGES

Abbott, B. P.; Abbott, R.; Abbott, T. D.; ...

2017-10-16

On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance ismore » $$5.0\\times {10}^{-8}$$. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of $$(+1.74\\pm 0.05)\\,{\\rm{s}}$$ between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between $$-3\\times {10}^{-15}$$ and $$+7\\times {10}^{-16}$$ times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1–1.4 per year during the 2018–2019 observing run and 0.3–1.7 per year at design sensitivity.« less

Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A

NASA Astrophysics Data System (ADS)

Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Afrough, M.; Agarwal, B.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allen, G.; Allocca, A.; Aloy, M. A.; Altin, P. A.; Amato, A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Angelova, S. V.; Antier, S.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Atallah, D. V.; Aufmuth, P.; Aulbert, C.; AultONeal, K.; Austin, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Bae, S.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Banagiri, S.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barkett, K.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Bawaj, M.; Bayley, J. C.; Bazzan, M.; Bécsy, B.; Beer, C.; Bejger, M.; Belahcene, I.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Bero, J. J.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscans, S.; Biscoveanu, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Bode, N.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonilla, E.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bossie, K.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T. A.; Calloni, E.; Camp, J. B.; Canepa, M.; Canizares, P.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Carney, M. F.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerdá-Durán, P.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chase, E.; Chassande-Mottin, E.; Chatterjee, D.; Chatziioannou, K.; Cheeseboro, B. D.; Chen, H. Y.; Chen, X.; Chen, Y.; Cheng, H.-P.; Chia, H.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, A. K. W.; Chung, S.; Ciani, G.; Ciolfi, R.; Cirelli, C. E.; Cirone, A.; Clara, F.; Clark, J. A.; Clearwater, P.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Cohen, D.; Colla, A.; Collette, C. G.; Cominsky, L. R.; Constancio, M., Jr.; Conti, L.; Cooper, S. J.; Corban, P.; Corbitt, T. R.; Cordero-Carrión, I.; Corley, K. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Dálya, G.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davis, D.; Daw, E. J.; Day, B.; De, S.; DeBra, D.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Demos, N.; Denker, T.; Dent, T.; De Pietri, R.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; De Rossi, C.; DeSalvo, R.; de Varona, O.; Devenson, J.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Doctor, Z.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Dreissigacker, C.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dupej, P.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Eisenstein, R. A.; Essick, R. C.; Estevez, D.; Etienne, Z. B.; Etzel, T.; Evans, M.; Evans, T. M.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fee, C.; Fehrmann, H.; Feicht, J.; Fejer, M. M.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Finstad, D.; Fiori, I.; Fiorucci, D.; Fishbach, M.; Fisher, R. P.; Fitz-Axen, M.; Flaminio, R.; Fletcher, M.; Fong, H.; Font, J. A.; Forsyth, P. W. F.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Ganija, M. R.; Gaonkar, S. G.; Garcia-Quiros, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, D.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glover, L.; Goetz, E.; Goetz, R.; Gomes, S.; Goncharov, B.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Gretarsson, E. M.; Groot, P.; Grote, H.; Grunewald, S.; Gruning, P.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Halim, O.; Hall, B. R.; Hall, E. D.; Hamilton, E. Z.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hannuksela, O. A.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hinderer, T.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Horst, C.; Hough, J.; Houston, E. A.; Howell, E. J.; Hreibi, A.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Inta, R.; Intini, G.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Johnson-McDaniel, N. K.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Kastaun, W.; Katolik, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kemball, A. J.; Kennedy, R.; Kent, C.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, K.; Kim, W.; Kim, W. S.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J. S.; Kleybolte, L.; Klimenko, S.; Knowles, T. D.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Krishnan, B.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kumar, S.; Kuo, L.; Kutynia, A.; Kwang, S.; Lackey, B. D.; Lai, K. H.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lanza, R. K.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, H. W.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Linker, S. D.; Littenberg, T. B.; Liu, J.; Lo, R. K. L.; Lockerbie, N. A.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lousto, C. O.; Lovelace, G.; Lück, H.; Lumaca, D.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macas, R.; Macfoy, S.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña Hernandez, I.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markakis, C.; Markosyan, A. S.; Markowitz, A.; Maros, E.; Marquina, A.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martynov, D. V.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McCuller, L.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McNeill, L.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Mejuto-Villa, E.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, B. B.; Miller, J.; Millhouse, M.; Milovich-Goff, M. C.; Minazzoli, O.; Minenkov, Y.; Ming, J.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moffa, D.; Moggi, A.; Mogushi, K.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E. A.; Muratore, M.; Murray, P. G.; Napier, K.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Neilson, J.; Nelemans, G.; Nelson, T. J. N.; Nery, M.; Neunzert, A.; Nevin, L.; Newport, J. M.; Newton, G.; Ng, K. K. Y.; Nguyen, T. T.; Nichols, D.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Noack, A.; Nocera, F.; Nolting, D.; North, C.; Nuttall, L. K.; Oberling, J.; O'Dea, G. D.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Okada, M. A.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; Ormiston, R.; Ortega, L. F.; O'Shaughnessy, R.; Ossokine, S.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pace, A. E.; Page, J.; Page, M. A.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, Howard; Pan, Huang-Wei; Pang, B.; Pang, P. T. H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Parida, A.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patil, M.; Patricelli, B.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perez, C. J.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pirello, M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Porter, E. K.; Post, A.; Powell, J.; Prasad, J.; Pratt, J. W. W.; Pratten, G.; Predoi, V.; Prestegard, T.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rajbhandari, B.; Rakhmanov, M.; Ramirez, K. E.; Ramos-Buades, A.; Rapagnani, P.; Raymond, V.; Razzano, M.; Read, J.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Ren, W.; Reyes, S. D.; Ricci, F.; Ricker, P. M.; Rieger, S.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, R.; Romel, C. L.; Romie, J. H.; Rosińska, D.; Ross, M. P.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Rutins, G.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sampson, L. M.; Sanchez, E. J.; Sanchez, L. E.; Sanchis-Gual, N.; Sandberg, V.; Sanders, J. R.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Sauter, O.; Savage, R. L.; Sawadsky, A.; Schale, P.; Scheel, M.; Scheuer, J.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schulte, B. W.; Schutz, B. F.; Schwalbe, S. G.; Scott, J.; Scott, S. M.; Seidel, E.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D. A.; Shaffer, T. J.; Shah, A. A.; Shahriar, M. S.; Shaner, M. B.; Shao, L.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, L. P.; Singh, A.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Smith, R. J. E.; Somala, S.; Son, E. J.; Sonnenberg, J. A.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Spencer, A. P.; Srivastava, A. K.; Staats, K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stevenson, S. P.; Stone, R.; Stops, D. J.; Strain, K. A.; Stratta, G.; Strigin, S. E.; Strunk, A.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Suresh, J.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Tait, S. C.; Talbot, C.; Talukder, D.; Tanner, D. B.; Tápai, M.; Taracchini, A.; Tasson, J. D.; Taylor, J. A.; Taylor, R.; Tewari, S. V.; Theeg, T.; Thies, F.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tonelli, M.; Tornasi, Z.; Torres-Forné, A.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trinastic, J.; Tringali, M. C.; Trozzo, L.; Tsang, K. W.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tuyenbayev, D.; Ueno, K.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Varma, V.; Vass, S.; Vasúth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Venugopalan, G.; Verkindt, D.; Vetrano, F.; Viceré, A.; Viets, A. D.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walet, R.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, J. Z.; Wang, W. H.; Wang, Y. F.; Ward, R. L.; Warner, J.; Was, M.; Watchi, J.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wessel, E. K.; Weßels, P.; Westerweck, J.; Westphal, T.; Wette, K.; Whelan, J. T.; Whitcomb, S. E.; Whiting, B. F.; Whittle, C.; Wilken, D.; Williams, D.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Wofford, J.; Wong, K. W. K.; Worden, J.; Wright, J. L.; Wu, D. S.; Wysocki, D. M.; Xiao, S.; Yamamoto, H.; Yancey, C. C.; Yang, L.; Yap, M. J.; Yazback, M.; Yu, Hang; Yu, Haocun; Yvert, M.; Zadrożny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, T.; Zhang, Y.-H.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, S. J.; Zhu, X. J.; Zimmerman, A. B.; Zucker, M. E.; Zweizig, J.; (LIGO Scientific Collaboration; Virgo Collaboration; Burns, E.; Veres, P.; Kocevski, D.; Racusin, J.; Goldstein, A.; Connaughton, V.; Briggs, M. S.; Blackburn, L.; Hamburg, R.; Hui, C. M.; von Kienlin, A.; McEnery, J.; Preece, R. D.; Wilson-Hodge, C. A.; Bissaldi, E.; Cleveland, W. H.; Gibby, M. H.; Giles, M. M.; Kippen, R. M.; McBreen, S.; Meegan, C. A.; Paciesas, W. S.; Poolakkil, S.; Roberts, O. J.; Stanbro, M.; Gamma-ray Burst Monitor, (Fermi; Savchenko, V.; Ferrigno, C.; Kuulkers, E.; Bazzano, A.; Bozzo, E.; Brandt, S.; Chenevez, J.; Courvoisier, T. J.-L.; Diehl, R.; Domingo, A.; Hanlon, L.; Jourdain, E.; Laurent, P.; Lebrun, F.; Lutovinov, A.; Mereghetti, S.; Natalucci, L.; Rodi, J.; Roques, J.-P.; Sunyaev, R.; Ubertini, P.; (INTEGRAL

2017-10-01

On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0× {10}-8. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of (+1.74+/- 0.05) {{s}} between GRB 170817A and GW170817 to: (I) constrain the difference between the speed of gravity and the speed of light to be between -3× {10}-15 and +7× {10}-16 times the speed of light, (II) place new bounds on the violation of Lorentz invariance, (III) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity.

Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abbott, B. P.; Abbott, R.; Abbott, T. D.

On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance ismore » $$5.0\\times {10}^{-8}$$. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of $$(+1.74\\pm 0.05)\\,{\\rm{s}}$$ between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between $$-3\\times {10}^{-15}$$ and $$+7\\times {10}^{-16}$$ times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1–1.4 per year during the 2018–2019 observing run and 0.3–1.7 per year at design sensitivity.« less

GRB 161219B/SN 2016jca: A low-redshift gamma-ray burst supernova powered by radioactive heating

NASA Astrophysics Data System (ADS)

Cano, Z.; Izzo, L.; de Ugarte Postigo, A.; Thöne, C. C.; Krühler, T.; Heintz, K. E.; Malesani, D.; Geier, S.; Fuentes, C.; Chen, T.-W.; Covino, S.; D'Elia, V.; Fynbo, J. P. U.; Goldoni, P.; Gomboc, A.; Hjorth, J.; Jakobsson, P.; Kann, D. A.; Milvang-Jensen, B.; Pugliese, G.; Sánchez-Ramírez, R.; Schulze, S.; Sollerman, J.; Tanvir, N. R.; Wiersema, K.

2017-09-01

Since the first discovery of a broad-lined type Ic supernova (SN) with a long-duration gamma-ray burst (GRB) in 1998, fewer than fifty GRB-supernovae (SNe) have been discovered. The intermediate-luminosity Swift GRB 161219B and its associated supernova SN 2016jca, which occurred at a redshift of z = 0.1475, represents only the seventh GRB-SN to have been discovered within 1 Gpc, and hence provides an excellent opportunity to investigate the observational and physical properties of these very elusive and rare type of SN. As such, we present optical to near-infrared photometry and optical spectroscopy of GRB 161219B and SN 2016jca, spanning the first three months since its discovery. GRB 161219B exploded in the disk of an edge-on spiral galaxy at a projected distance of 3.4 kpc from the galactic centre. GRB 161219B itself is an outlier in the Ep,I - Eγ,iso plane, while SN 2016jca had a rest-frame, peak absolute V-band magnitude of MV = - 19.0 ± 0.1, which it reached after 12.3 ± 0.7 rest-frame days. We find that the bolometric properties of SN 2016jca are inconsistent with being powered solely by a magnetar central engine, and demonstrate that it was likely powered exclusively by energy deposited by the radioactive decay of nickel and cobalt into their daughter products, which were nucleosynthesised when its progenitor underwent core collapse. We find that 0.22 ± 0.08M⊙ of nickel is required to reproducethe peak luminosity of SN 2016jca, and we constrain an ejecta mass of 5.8 ± 0.3M⊙ and a kinetic energy of 5.1 ± 0.8 × 1052 erg. Finally, we report on a chromatic, pre-maximum bump in the g-band light curve, and discuss its possible origin.

Young, metal-enriched cores in early-type dwarf galaxies in the Virgo cluster based on colour gradients

NASA Astrophysics Data System (ADS)

Urich, Linda; Lisker, Thorsten; Janz, Joachim; van de Ven, Glenn; Leaman, Ryan; Boselli, Alessandro; Paudel, Sanjaya; Sybilska, Agnieszka; Peletier, Reynier F.; den Brok, Mark; Hensler, Gerhard; Toloba, Elisa; Falcón-Barroso, Jesús; Niemi, Sami-Matias

2017-10-01

Early-type dwarf galaxies are not simply featureless, old objects, but were found to be much more diverse, hosting substructures and a variety of stellar population properties. To explore the stellar content of faint early-type galaxies, and to investigate in particular those with recent central star formation, we study colours and colour gradients within one effective radius in optical (g - r) and near-infrared (I - H) bands for 120 Virgo cluster early-type galaxies with - 19 mag

Firework Model: Time Dependent Spectral Evolution of GRB

NASA Astrophysics Data System (ADS)

Barbiellini, Guido; Longo, Francesco; Ghirlanda, G.; Celotti, A.; Bosnjak, Z.

2004-09-01

The energetics of the long duration GRB phenomenon is compared with models of a rotating BH in a strong magnetic field generated by an accreting torus. The GRB energy emission is attributed to magnetic field vacuum breakdown that gives origin to a e +/- fireball. Its subsequent evolution is hypothesized in analogy with the in-flight decay of an elementary particle. An anisotropy in the fireball propagation is thus naturally produced. The recent discovery in some GRB of an initial phase characterized by a thermal spectrum could be interpreted as the photon emission of the fireball photosphere when it becomes transparent. In particular, the temporal evolution of the emission can be explained as the effect of a radiative deceleration of the out-moving ejecta.

Southern Fireworks above ESO Telescopes

NASA Astrophysics Data System (ADS)

1999-05-01

New Insights from Observations of Mysterious Gamma-Ray Burst International teams of astronomers are now busy working on new and exciting data obtained during the last week with telescopes at the European Southern Observatory (ESO). Their object of study is the remnant of a mysterious cosmic explosion far out in space, first detected as a gigantic outburst of gamma rays on May 10. Gamma-Ray Bursters (GRBs) are brief flashes of very energetic radiation - they represent by far the most powerful type of explosion known in the Universe and their afterglow in optical light can be 10 million times brighter than the brightest supernovae [1]. The May 10 event ranks among the brightest one hundred of the over 2500 GRB's detected in the last decade. The new observations include detailed images and spectra from the VLT 8.2-m ANTU (UT1) telescope at Paranal, obtained at short notice during a special Target of Opportunity programme. This happened just over one month after that powerful telescope entered into regular service and demonstrates its great potential for exciting science. In particular, in an observational first, the VLT measured linear polarization of the light from the optical counterpart, indicating for the first time that synchrotron radiation is involved . It also determined a staggering distance of more than 7,000 million light-years to this GRB . The astronomers are optimistic that the extensive observations will help them to better understand the true nature of such a dramatic event and thus to bring them nearer to the solution of one of the greatest riddles of modern astrophysics. A prime example of international collaboration The present story is about important new results at the front-line of current research. At the same time, it is also a fine illustration of a successful collaboration among several international teams of astronomers and the very effective way modern science functions. It began on May 10, at 08:49 hrs Universal Time (UT), when the Burst And Transient Source Experiment (BATSE) onboard NASA's Compton Gamma-Ray Observatory (CGRO) high in orbit around the Earth, suddenly registered an intense burst of gamma-ray radiation from a direction less than 10° from the celestial south pole. Independently, the Gamma-Ray Burst Monitor (GRBM) on board the Italian-Dutch BeppoSAX satellite also detected the event (see GCN GRB Observation Report 304 [2]). Following the BATSE alert, the BeppoSAX Wide-Field Cameras (WFC) quickly localized the sky position of the burst within a circle of 3 arcmin radius in the southern constellation Chamaeleon. It was also detected by other satellites, including the ESA/NASA Ulysses spacecraft , since some years in a wide orbit around the Sun. The event was designated GRB 990510 and the measured position was immediately distributed by BeppoSAX Mission Scientist Luigi Piro to a network of astronomers. It was also published on Circular No. 7160 of the International Astronomical Union (IAU). From Amsterdam (The Netherlands), Paul Vreeswijk, Titus Galama , and Evert Rol of the Amsterdam/Huntsville GRB follow-up team (led by Jan van Paradijs ) immediately contacted astronomers at the 1-meter telescope of the South African Astronomical Observatory (SAAO) (Sutherland, South Africa) of the PLANET network microlensing team, an international network led by Penny Sackett in Groningen (The Netherlands). There, John Menzies of SAAO and Karen Pollard (University of Canterbury, New Zealand) were about to begin the last of their 14 nights of observations, part of a continuous world-wide monitoring program looking for evidence of planets around other stars. Other PLANET sites in Australia and Tasmania where it was still nighttime were unfortunately clouded out (some observations were in fact made that night at the Mount Stromlo observatory in Australia, but they were only announced one day later). As soon as possible - immediately after sundown and less than 9 hours after the initial burst was recorded - the PLANET observers turned their telescope and quickly obtained a series of CCD images in visual light of the sky region where the gamma-ray burst was detected, then shipped them off electronically to their Dutch colleagues [3]. Comparing the new photos with earlier ones in the digital sky archive, Vreeswijk, Galama and Rol almost immediately discovered a new, relatively bright visual source in the region of the gamma-ray burst, which they proposed as the optical counterpart of the burst, cf. their dedicated webpage at http://www.astro.uva.nl/~titus/grb990510/. The team then placed a message on the international Gamma-Ray Burster web-noteboard ( GCN Circular 310), thereby alerting their colleagues all over the world. One hour later, the narrow-field instruments on BeppoSax identified a new X-Ray source at the same location ( GCN Circular 311), thus confirming the optical identification. All in all, a remarkable synergy of human and satellite resources! Observations of GRB 990510 at ESO Vreeswijk, Galama and Rol, in collaboration with Nicola Masetti, Eliana Palazzi and Elena Pian of the BeppoSAX GRB optical follow-up team (led by Filippo Frontera ) and the Huntsville optical follow-up team (led by Chryssa Kouveliotou ), also contacted the European Southern Observatory (ESO). Astronomers at this Organization's observatories in Chile were quick to exploit this opportunity and crucial data were soon obtained with several of the main telescopes at La Silla and Paranal, less than 14 hours after the first detection of this event by the satellite. ESO PR Photo 22a/99 ESO PR Photo 22a/99 [Preview - JPEG: 211 x 400 pix - 72k] [Normal - JPEG: 422 x 800 pix - 212k] [High-Res - JPEG: 1582 x 3000 pix - 2.6M] ESO PR Photo 22b/99 ESO PR Photo 22b/99 [Preview - JPEG: 400 x 437 pix - 297k] [Normal - JPEG: 800 x 873 pix - 1.1M] [High-Res - JPEG: 2300 x 2509 pix - 5.9M] Caption to PR Photo 22a/99 : This wide-field photo was obtained with the Wide-Field Imager (WFI) at the MPG/ESO 2.2-m telescope at La Silla on May 11, 1999, at 08:42 UT, under inferior observing conditions (seeing = 1.9 arcsec). The exposure time was 450 sec in a B(lue) filter. The optical image of the afterglow of GRB 990510 is indicated with an arrow in the upper part of the field that measures about 8 x 16 arcmin 2. The original scale is 0.24 pix/arcsec and there are 2k x 4k pixels in the original frame. North is up and East is left. Caption to PR Photo 22b/99 : This is a (false-)colour composite of the area around the optical image of the afterglow of GRB 990510, based on three near-infrared exposures with the SOFI multi-mode instrument at the 3.6-m ESO New Technology Telescope (NTT) at La Silla, obtained on May 10, 1999, between 23:15 and 23:45 UT. The exposure times were 10 min each in the J- (1.2 µm; here rendered in blue), H- (1.6 µm; green) and K-bands (2.2 µm; red); the image quality is excellent (0.6 arcsec). The field measures about 5 x 5 arcmin 2 ; the original pixel size is 0.29 arcsec. North is up and East is left. ESO PR Photo 22c/99 ESO PR Photo 22c/99 [Preview - JPEG: 400 x 235 pix - 81k] [Normal - JPEG: 800 x 469 pix - 244k] [High-Res - JPEG: 2732 x 1603 pix - 2.6M] ESO PR Photo 22d/99 ESO PR Photo 22d/99 [Preview - JPEG: 400 x 441 pix - 154k] [Normal - JPEG: 800 x 887 pix - 561k] [High-Res - JPEG: 2300 x 2537 pix - 2.3M] Caption to PR Photo 22c/99 : To the left is a reproduction of a short (30 sec) centering exposure in the V-band (green-yellow light), obtained with VLT ANTU and the multi-mode FORS1 instrument on May 11, 1999, at 03:48 UT under mediocre observing conditions (image quality 1.0 arcsec).The optical image of the afterglow of GRB 990510 is easily seen in the box, by comparison with an exposure of the same sky field before the explosion, made with the ESO Schmidt Telescope in 1986 (right).The exposure time was 120 min on IIIa-F emulsion behind a R(ed) filter. The field shown measures about 6.2 x 6.2 arcmin 2. North is up and East is left. Caption to PR Photo 22d/99 : Enlargement from the 30 sec V-exposure by the VLT, shown in Photo 22c/99. The field is about 1.9 x 1.9 arcmin 2. North is up and East is left. The data from Chile were sent to Europe where, by quick comparison of images from the Wide-Field Imager (WFI) at the MPG/ESO 2.2-m telescope at La Silla with those from SAAO, the Dutch and Italian astronomers found that the brightness of the suspected optical counterpart was fading rapidly; this was a clear sign that the identification was correct ( GCN Circular 313). With the precise sky position of GRB 990510 now available, the ESO observers at the VLT were informed and, setting other programmes aside under the Target of Opportunity scheme, were then able to obtain polarimetric data as well as a very detailed spectrum of the optical counterpart. Comprehensive early observations of this object were also made at La Silla with the ESO 3.6-m telescope (CCD images in the UBVRI-bands from the ultraviolet to the near-infrared part of the spectrum) and the ESO 3.6-m New Technology Telescope (with the SOFI multimode instrument in the infrared JHK-bands). A series of optical images in the BVRI-bands was secured with the Danish 1.5-m telescope, documenting the rapid fading of the object. Observations at longer wavelengths were made with the 15-m Swedish-ESO Submillimetre Telescope (SEST). All of the involved astronomers concur that a fantastic amount of observations has been obtained. They are still busy analyzing the data, and are confident that much will be learned from this particular burst. The VLT scores a first: Measurement of GRB polarization ESO PR Photo 22e/99 ESO PR Photo 22e/99 [Preview - JPEG: 400 x 434 pix - 92k] [Normal - JPEG: 800 x 867 pix - 228k] Caption to PR Photo 22e/99 : Preliminary polarization measurement of the optical image of the afterglow of GRB 990510, as observed with the VLT 8.2-m ANTU telescope and the multi-mode FORS1 instrument. The abscissa represents the measurement angle; the ordinate the corresponding intensity. The sinusoidal curve shows the best fit to the data points (with error bars); the resulting degree of polarization is 1.7 ± 0.2 percent. A group of Italian astronomers led by Stefano Covino of the Observatory of Brera in Milan, have observed for the first time polarization (some degree of alignment of the electric fields of emitted photons) from the optical afterglow of a gamma-ray burst, see their dedicated webpage at http://www.merate.mi.astro.it/~lazzati/GRB990510/. This yielded a polarization at a level of 1.7 ± 0.2 percent for the optical afterglow of GRB 990510, some 18 hours after the gamma-ray burst event; the magnitude was R = 19.1 at the time of this VLT observation. Independently, the Dutch astronomers Vreeswijk, Galama and Rol measured polarization of the order of 2 percent with another data set from the VLT ANTU and FORS1 obtained during the same night. This important result was made possible by the very large light-gathering power of the 8.2-m VLT-ANTU mirror and the FORS1 imaging polarimeter. Albeit small, the detected degree of polarization is highly significant; it is also one of the most precise measurements of polarization ever made in an object as faint as this one. Most importantly, it provides the strongest evidence to date that the afterglow radiation of gamma-ray bursts is, at least in part, produced by the synchrotron process , i.e. by relativistic electrons spiralling in a magnetized region. This type of process is able to imprint some linear polarization on the produced radiation, if the magnetic field is not completely chaotic. The spectrum ESO PR Photo 22f/99 ESO PR Photo 22f/99 [Preview - JPEG: 400 x 485 pix - 112k] [Normal - JPEG: 800 x 969 pix - 288k] Caption to PR Photo 22f/99 : A spectrum of the afterglow of GRB 990510, obtained with VLT ANTU and the multi-mode FORS1 instrument during the night of May 10-11, 1999. Some of the redshifted absorption lines are identified and the stronger bands from the terrestrial atmosphere are also indicated. A VLT spectrum with the multi-mode FORS1 instrument was obtained a little later and showed a number of absorption lines , e.g. from ionized Aluminium, Chromium and neutral Magnesium. They do not arise in the optical counterpart itself - the gas there is so hot and turbulent that any spectral lines will be extremely broad and hence extremely difficult to identify - but from interstellar gas in a galaxy 'hosting' the GRB source, or from intergalactic clouds along the line of sight. It is possible to measure the distance to this intervening material from the redshift of the lines; astronomers Vreeswijk, Galama and Rol found z = 1.619 ± 0.002 [4]. This allows to establish a lower limit for the distance of the explosion and also its total power. The numbers turn out to be truly enormous. The burst occurred at an epoch corresponding to about one half of the present age of the Universe (at a distance of about 7,000 million light-years [5]), and the total energy of the explosion in gamma-rays must be higher than 1.4 10 53 erg , assuming a spherical emission. This energy corresponds to the entire optical energy emitted by the Milky Way in more than 30 years; yet the gamma-ray burst took less than 100 seconds. Since the optical afterglows of gamma-ray bursts are faint, and their flux decays quite rapidly in time, the combination of large telescopes and fast response through suitable observing programs are crucial and, as demonstrated here, ESO's VLT is ideally suited to this goal! The lightcurve Combining results from a multitude of telescopes has provided most useful information. Interestingly, a "break" was observed in the light curve (the way the light of the optical counterpart fades) of the afterglow. Some 1.5 - 2 days after the explosion, the brightness began to decrease more rapidly; this is well documented with the CCD images from the Danish 1.5-m telescope at La Silla and the corresponding diagrams are available on a dedicated webpage at http://www.astro.ku.dk/~jens/grb990510/ at the Copenhagen University Observatory. Complete, regularly updated lightcurves with all published measurements, also from other observatories, may be found at another webpage in Milan at http://www.merate.mi.astro.it/~gabriele/990510/ . This may happen if the explosion emits radiation in a beam which is pointed towards the Earth. Such beams are predicted by some models for the production of gamma-ray bursts. They are also favoured by many astronomers, because they can overcome the fundamental problem that gamma-ray bursts simply produce too much energy. If the energy is not emitted equally in all directions ("isotropically"), but rather in a preferred one along a beam, less energy is needed to produce the observed phenomenon. Such a break has been observed before, but this time it occurred at a very favourable moment, when the source was still relatively bright so that high-quality spectroscopic and multi-colour information could be obtained with the ESO telescopes. Together, these observations may provide an answer to the question whether beams exist in gamma-ray bursts and thus further help us to understand the as yet unknown cause of these mysterious explosions. Latest News ESO PR Photo 22g/99 ESO PR Photo 22g/99 [Normal - JPEG: 453 x 585 pix - 304k] Caption to PR Photo 22g/99 : V(isual) image of the sky field around GRB 990510 (here denoted "OT"), as obtained with the VLT ANTU telescope and FORS1 on May 18 UT during a 20 min exposure in 0.9 arcsec seeing conditions. The reproduction is in false colours to better show differences in intensity. North is up and east is left. Further photometric and spectroscopic observations with the ESO VLT, performed by Klaus Beuermann, Frederic Hessman and Klaus Reinsch of the Göttingen group of the FORS instrument team (Germany), have revealed the character of some of the objects that are seen close to the image of the afterglow of GRB 990510 (also referred to as the "Optical Transient" - OT). Two objects to the North are cool foreground stars of spectral types dM0 and about dM3, respectively; they are located in our Milky Way Galaxy. The object just to the South of the OT is probably also a star. A V(isual)-band image (PR Photo 22g/99) taken during the night between May 17 and 18 with the VLT/ANTU telescope and FORS1 now shows the OT at magnitude V = 24.5, with still no evidence for the host galaxy that is expected to appear when the afterglow has faded sufficiently. Outlook The great distances (high redshifts) of Gamma-Ray Bursts, plus the fact that a 9th magnitude optical flash was seen when another GRB exploded on January 23 this year, has attracted the attention of astronomers outside the GRB field. In fact, GRBs may soon become a very powerful tool to probe the early universe by guiding us to regions of very early star formation and the (proto)-galaxies and (proto)-clusters of which they are part. They will also allow the study of the chemical composition of absorbing clouds at very large distances. At the end of this year, the NASA satellite HETE-II will be launched, which is expected to provide about 50 GRB alerts per year and, most importantly, accurate localisations in the sky that will allow very fast follow-up observations, while the optical counterparts are still quite bright. It will then be possible to obtain more spectra, also of extremely distant bursts, and many new distance determinations can be made, revealing the distribution of intrinsic brightness of GRB's (the "luminosity function"). Other types of observations (e.g. polarimetry, as above) will also profit, leading to a progressive refinement of the available data. Thus there is good hope that astronomers will soon come closer to identifying the progenitors of these enormous explosions and to understand what is really going on. In this process, the huge light-collecting power of the VLT and the many other facilities at the ESO observatories will undoubtedly play an important role. Notes [1] Gamma-Ray Bursts are brief flashes of high-energy radiation. Satellites in orbit around the Earth and spacecraft in interplanetary orbits have detected several thousand such events since they were first discovered in the late 1960s. Earlier investigations established that they were so evenly distributed in the sky that they must be very distant (and hence very powerful) outbursts of some kind. Only in 1997 it became possible to observe the fading "afterglow" of one of these explosions in visible light, thanks to accurate positions available from the BeppoSAX satellite. Soon thereafter, another optical afterglow was detected; it was located in a faint galaxy whose distance could be measured. In 1998, a gamma-ray burst was detected in a galaxy over 8,300 million light-years away. Even the most exotic ideas proposed for these explosions, e.g. supergiant stars collapsing to black holes, black holes merging with neutron stars or other black holes, and other weird and wonderful notions have trouble accounting for explosions with the power of 10,000 million million suns. [2] The various reports issued by astronomers working on this and other gamma-ray burst events are available as GCN Circulars on the GRB Coordinates Network web-noteboard. [3] See also the Press Release, issued by SAAO on this occasion. [4] In astronomy, the redshift (z) denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. The observed redshift of a distant galaxy or intergalactic cloud gives a direct estimate of the universal expansion (i.e. the "recession velocity"). The detailed relation between redshift and distance depends on such quantities as the Hubble Constant, the average density of the universe, and the 'cosmological' Constant. For a standard cosmological model, redshift z = 1.6 corresponds to a distance of about 7,000 million light-years. [5] Assuming a Hubble Constant H 0 = 70 km/s/Mpc, mean density Omega 0 = 0.3 and a Cosmological Constant Lambda = 0. How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org../ ). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

The early phase of the SMBH-galaxy coevolution in low-z "young" galaxies

NASA Astrophysics Data System (ADS)

Nagao, Tohru

2014-01-01

It is now widely recognized that most galaxies have a supermassive black hole (SMBH) in their nucleus, and the evolution of SMBHs is closely related with that of their host galaxies (the SMBH-galaxy coevolution). This is suggested by the correlation in the mass of SMBHs and their host galaxies, that has been observed in low redshifts. However, the physics of the coevolution is totally unclear, that prevents us from complete understandings of the galaxy evolution. One possible strategy to tackle this issue is measuring the mass ratio between SMBHs and their host galaxies (M_BH/M_host) at high redshifs, since different scenarios predict different evolution of the ratio ofMBH/Mhost. However it is extremely challenging to measure the mass of the host of high-z quasars, given the faint surface brightness of the host at close to the glaring quasar nucleus. Here we propose a brand-new approach to assess the early phase of the SMBH-galaxy coevolution, by focusing on low-z AGN-hosting "young" galaxies. Specifically, we focus on some very metal-poor galaxies with broadline Balmer lines at z ~ 0.1 - 0.3. By examining the SMBH scaling relations in some low-z metal-poor AGNs through high-resolution IRCS imaging observations, we will discriminate various scenarios for the SMBH-galaxy coevolution.

The Observer's Guide to the Gamma-Ray Burst-Supernova Connection

NASA Astrophysics Data System (ADS)

Cano, Z.

2016-10-01

In this review we present a progress report of the connection between long-duration gamma-ray bursts (GRBs) and their accompanying supernovae (SNe). The analysis is from the point of view of an observer, with much of the emphasis placed on how observations, and the modelling of observations, have constrained what we known about GRB-SNe. We discuss their photometric and spectroscopic properties, their role as cosmological probes, including their measured luminosity-decline relationships, and how they can be used to measure the Hubble constant. We present a statistical analysis of their bolometric properties, and use this to determine the properties of the "average" GRB-SNe: which has a kinetic energy of EK≈2.5×10^52 erg, an ejecta mass of Mej≈6 M⊙, a nickel mass of MNi≈0.4 M⊙, a peak photospheric velocity of vph≈21,000 km s-1, a peak bolometric luminosity of Lp≈1×10^43 erg s-1, and it reaches peak bolometric light in tp≈13 days. We discuss their geometry, consider the various physical processes that are thought to power the luminosity of GRB-SNe, and whether differences exist between GRB-SNe and the SNe associated with ultra-long duration GRBs. We discuss how observations of the environments of GRB-SNe further constrain the physical properties of their progenitor stars, and give an overview of the current theoretical paradigms of their suspected central engines. We also present an overview of the radioactively powered transients that have been photometrically associated with short-duration GRBs. We conclude the review by discussing what additional research is needed to further our understanding of GRB-SNe, in particular the role of binary-formation channels and the connection of GRB-SNe with superluminous SNe (abridged).

Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide.

PubMed

Papaioannou, Danai; Geibel, Sebastian; Kunze, Micha B A; Kay, Christopher W M; Waksman, Gabriel

2016-03-01

The adaptor protein Grb2 is a key element of mitogenetically important signaling pathways. With its SH2 domain it binds to upstream targets while its SH3 domains bind to downstream proteins thereby relaying signals from the cell membranes to the nucleus. The Grb2 SH2 domain binds to its targets by recognizing a phosphotyrosine (pY) in a pYxNx peptide motif, requiring an Asn at the +2 position C-terminal to the pY with the residue either side of this Asn being hydrophobic. Structural analysis of the Grb2 SH2 domain in complex with its cognate peptide has shown that the peptide adopts a unique β-turn conformation, unlike the extended conformation that phosphopeptides adopt when bound to other SH2 domains. TrpEF1 (W121) is believed to force the peptide into this unusual conformation conferring this unique specificity to the Grb2 SH2 domain. Using X-ray crystallography, electron paramagnetic resonance (EPR) spectroscopy, and isothermal titration calorimetry (ITC), we describe here a series of experiments that explore the role of TrpEF1 in determining the specificity of the Grb2 SH2 domain. Our results demonstrate that the ligand does not adopt a pre-organized structure before binding to the SH2 domain, rather it is the interaction between the two that imposes the hairpin loop to the peptide. Furthermore, we find that the peptide adopts a similar structure when bound to both the wild-type Grb2 SH2 domain and a TrpEF1Gly mutant. This suggests that TrpEF1 is not the determining factor for the conformation of the phosphopeptide. © 2015 The Protein Society.

DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed.

PubMed

Hitchins, Megan P; Bentley, Louise; Monk, David; Beechey, Colin; Peters, Jo; Kelsey, Gavin; Ishino, Fumitoshi; Preece, Michael A; Stanier, Philip; Moore, Gudrun E

2002-12-01

Maternal duplication of human 7p11.2-p13 has been associated with Silver-Russell syndrome (SRS) in two familial cases. GRB10 is the only imprinted gene identified within this region to date. GRB10 demonstrates an intricate tissue- and isoform-specific imprinting profile in humans, with paternal expression in fetal brain and maternal expression of one isoform in skeletal muscle. The mouse homolog is maternally transcribed. The GRB10 protein is a potent growth inhibitor and represents a candidate for SRS, which is characterized by pre- and postnatal growth retardation and a spectrum of additional dysmorphic features. Since imprinted genes tend to be grouped in clusters, we investigated the imprinting status of the dopa-decarboxylase gene (DDC) and the Cordon-bleu gene (COBL) which flank GRB10 within the 7p11.2-p13 SRS duplicated region. Although both genes were found to replicate asynchronously, suggestive of imprinting, SNP expression analyses showed that neither gene was imprinted in multiple human fetal tissues. The mouse homologues, Ddc and Cobl, which map to the homologous imprinted region on proximal Chr 11, were also biallelically expressed in mice with uniparental maternal or paternal inheritance of this region. With the intent of using mouse Grb10 as an imprinted control, biallelic expression was consistently observed in fetal, postnatal, and adult brain of these mice, in contrast to the maternal-specific transcription previously demonstrated in brain in inter-specific F1 progeny. This may be a further example of over-expression of maternally derived transcripts in inter-specific mouse crosses. GRB10 remains the only imprinted gene identified within 7p11.2-p13.

COMPTEL Studies of Gamma-Ray Bursts at MeV Energies

NASA Technical Reports Server (NTRS)

McConnell, Mark L.

1999-01-01

The purpose of this program was to analyse and interpret gamma-ray burst (GRB) data using both telescope mode data and single detector burst mode data from COMPTEL. Collectively, these data span the energy range from 300 keV up to 30 MeV. The initial goal of our proposal was to perform a standard analysis for each significant GRB event seen by COMPTEL. This includes GRBs that are registered by the telescope mode data as well as GRBs that are registered only in the burst mode data. (The latter category includes both GRBs that he outside of the FoV as well as GRBs within the FoV that are too weak to be seen in the telescope mode.) A second goal of our proposal was to define a set of data products (including deconvolved photon spectra) that, for each detected GRB event, would be made available via the COMPTEL GRB Web Page. The third goal of our program was to perform more detailed studies of selected GRB events. This represented a continuation of past GRB studies by the COMPTEL team. In general, we have met with only limited success in achieving these goals, in part due to the limited resources provided and our philosophy of utilizing local high school students to participate in this effort. Using local high school student support, however, we expect that considerable progress will be made in our efforts to catalog the COMPTEL gamma-ray burst data between now and the end of the current academic year. In addition, observations with COMPTEL contributed to an analysis of GRB 990123, the first gamma-ray burst with simultaneous optical observations.

Growth of chronic myeloid leukemia cells is inhibited by infection with Ad-SH2-HA adenovirus that disrupts Grb2-Bcr-Abl complexes.

PubMed

Peng, Zhi; Luo, Hong-Wei; Yuan, Ying; Shi, Jing; Huang, Shi-Feng; Li, Chun-Li; Cao, Wei-Xi; Huang, Zong-Gan; Feng, Wen-Li

2011-05-01

The persistence of Bcr-Abl-positive cells in patients on imatinib therapy indicates that inhibition of the Bcr-Abl kinase activity alone might not be sufficient to eradicate the leukemia cells. Many downstream effectors of Bcr-Abl have been described, including activation of both the Grb2-SoS-Ras-MAPK and Grb2-Gab2-PI3K-Akt pathways. The Bcr-Abl-Grb2 interaction, which is mediated by the direct interaction of the Grb2 SH2 domain with the phospho-Bcr-Abl Y177, is required for activation of these signaling pathways. Therefore, disrupting their interaction represents a potential therapeutic strategy for inhibiting the oncogenic downstream signals of Bcr-Abl. Adenovirus Ad-SH2-HA expressing the Grb2 SH2 domain was constructed and applied in this study. As expected, Ad-SH2-HA efficiently infected CML cells and functioned by binding to the phospho-Bcr-Abl Y177 site, competitively disrupting the Grb2 SH2-phospho-Bcr-Abl Y177 complex. They induced potent anti-proliferation and apoptosis-inducing effects in CML cell lines. Moreover, the Ras, MAPK and Akt activities were significantly reduced in the Ad-SH2-HA treated cells. These were not observed with the point-mutated control adenovirus Ad-Sm-HA with abolished phospho-Bcr-Abl Y177 binding sites. These data indicate that, in addition to the direct targeting of Bcr-Abl, selective inhibition of its downstream signaling pathways may be a therapeutic option for CML, and the Ad-SH2-HA-mediated killing strategy could be explored as a promising anti-leukemia agent in CML.

RAPTOR: Closed-Loop monitoring of the night sky and the earliest optical detection of GRB 021211

NASA Astrophysics Data System (ADS)

Vestrand, W. T.; Borozdin, K.; Casperson, D. J.; Fenimore, E.; Galassi, M.; McGowan, K.; Starr, D.; White, R. R.; Wozniak, P.; Wren, J.

2004-10-01

We discuss the RAPTOR (Rapid Telescopes for Optical Response) sky monitoring system at Los Alamos National Laboratory. RAPTOR is a fully autonomous robotic system that is designed to identify and make follow-up observations of optical transients with durations as short as one minute. The RAPTOR design is based on Biomimicry of Human Vision. The sky monitor is composed of two identical arrays of telescopes, separated by 38 kilometers, which stereoscopically monitor a field of about 1300 square-degrees for transients. Both monitoring arrays are carried on rapidly slewing mounts and are composed of an ensemble of wide-field telescopes clustered around a more powerful narrow-field telescope called the ``fovea'' telescope. All telescopes are coupled to real-time analysis pipelines that identify candidate transients and relay the information to a central decision unit that filters the candidates to find real celestial transients and command a response. When a celestial transient is found, the system can point the fovea telescopes to any position on the sky within five seconds and begin follow-up observations. RAPTOR also responds to Gamma Ray Burst (GRB) alerts generated by GRB monitoring spacecraft. Here we present RAPTOR observations of GRB 021211 that constitute the earliest detection of optical emission from that event and are the second fastest achieved for any GRB. The detection of bright optical emission from GRB021211, a burst with modest gamma-ray fluence, indicates that prompt optical emission, detectable with small robotic telescopes, is more common than previously thought. Further, the very fast decline of the optical afterglow from GRB 021211 suggests that some so-called ``optically dark'' GRBs were not detected only because of the slow response of the follow-up telescopes.

A Robotic System Discovers Contemporaneous Optical Radiation from a Gamma-Ray Burst

NASA Astrophysics Data System (ADS)

Bloch, J. J.; Akerlof, C.; Balsano, R.; Barthelmy, S.; Butterworth, P.; Casperson, D.; Cline, T.; Fletcher, S.; Frontera, F.; Gisler, G.; Heise, J.; Hills, J.; Kehoe, R.; Lee, B.; Marshall, S.; McKay, T.; Miller, R. S.; Piro, L.; Priedhorsky, W.; Szymanski, J.; Wren, J.; ROTSE Team

2000-05-01

Since their discovery more than 25 years ago (Klebesadel et al, 1973), the origin of gamma-ray bursts (GRBs) has been profoundly enigmatic. This situation improved radically in 1997 when coordinates provided by the BeppoSAX satellite enabled the delayed detection of faint optical afterglows associated with GRBs which demonstrated that these phenomena are at truly cosmological distances. However the brief duration of gamma-ray bursts has hitherto precluded optical detection while the burst was still in progress. We report here the first discovery of such a signal from GRB 990123, a remarkably bright and distant event using a robotic observation system. The light curve was sampled 7 times in the interval between 22 and 600 seconds following the burst onset. Over this time span, the brightness increased by 3 magnitudes to mv ~ 9 in 25 seconds and then waned by 5 magnitudes 8 minutes later before falling below detection threshold. The absolute magnitude of this object at peak brightness is <= -36.4, about 6 x 106 times as bright as a type Ia supernova, making this the most luminous object ever detected. The discovery reported here was performed with ROTSE-I, a four-fold robotic array of 35 mm camera telephoto lenses coupled to large format CCD imagers mounted on a rapidly slewing platform and having a composite FOV of 16° x 16° . The instrument is directly connected to the GRB Coordinates Network (GCN). The apparatus is installed at Los Alamos National Laboratory in northern New Mexico and runs autonomously. When ROTSE-I is not responding to GRBs, it is automatically recording the visible sky twice every night down to a limiting magnitude of mv ~ 14-15. Over 2 TBytes of sky data has been collected since ROTSE-I began operations. This talk will describe the details and implications of this remarkable detection and the instrumentation used to obtain it. It will also discuss the next generation instrumentation (ROTSE-II,III) that the project will produce and field at various worldwide sites. This work was supported by NASA and the Department of Energy.

FALL-BACK DISKS IN LONG AND SHORT GAMMA-RAY BURSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cannizzo, J. K.; Troja, E.; Gehrels, N., E-mail: John.K.Cannizzo@nasa.gov

2011-06-10

We present time-dependent numerical calculations for fall-back disks relevant to gamma-ray bursts (GRBs) in which the disk of material surrounding the black hole powering the GRB jet modulates the mass flow and hence the strength of the jet. Given the initial existence of a small mass {approx}< 10{sup -4} M{sub sun} near the progenitor with a circularization radius {approx}10{sup 10}-10{sup 11} cm, an unavoidable consequence will be the formation of an 'external disk' whose outer edge continually moves to larger radii due to angular momentum transport and lack of a confining torque. For long GRBs, if the mass distribution inmore » the initial fall-back disk traces the progenitor envelope, then a radius {approx}10{sup 11} cm gives a timescale {approx}10{sup 4} s for the X-ray plateau. For late times t > 10{sup 7} s a steepening due to a cooling front in the disk may have observational support in GRB 060729. For short GRBs, one expects most of the mass initially to lie at small radii <10{sup 8} cm; however, the presence of even a trace amount {approx}10{sup -9} M{sub sun} of high angular material can give a brief plateau in the light curve. By studying the plateaus in the X-ray decay of GRBs, which can last up to {approx}10{sup 4} s after the prompt emission, Dainotti et al. find an apparent inverse relation between the X-ray luminosity at the end of the plateau and the duration of the plateau. We show that this relation may simply represent the fact that one is biased against detecting faint plateaus and therefore preferentially sampling the more energetic GRBs. If, however, there were a standard reservoir in fall-back mass, our model could reproduce the inverse X-ray luminosity-duration relation. We emphasize that we do not address the very steep, initial decays immediately following the prompt emission, which have been modeled by Lindner et al. as fall back of the progenitor core, and may entail the accretion of {approx}> 1 M{sub sun}.« less

Gamma-ray bursts: The central engine

NASA Astrophysics Data System (ADS)

Woosley, S. E.

2000-09-01

A variety of arguments suggest that the most common form of gamma-ray bursts (GRBs), those longer than a few seconds, involve the formation of black holes in supernova-like events. Two kinds of ``collapsar'' models are discussed, those in which the black hole forms promptly-a second or so after iron core collapse-and those in which formation occurs later, following ``fallback'' over a period of minutes to hours. In most cases, extraction of energy from a rapidly accreting disk (and a rapidly rotating black hole) is achieved by magnetohydrodynamical processes, although neutrino-powered models remain viable in cases where the accretion rate is >~0.05Msolar s-1. GRBs are but one observable phenomenon accompanying black hole birth and other possibilities are discussed, some of which (long, faint GRBs and soft x-ray transients) may await discovery. Since they all involve black holes of similar mass accreting one to several Msolar, collapsars have a nearly standard total energy, around 1052 erg, but both the fraction of that energy ejected as highly relativistic matter and the distribution of that energy with angle can be highly variable. An explanation is presented why inferred GRB luminosity might correlate inversely with time scales and arguments are given against the production of ordinary GRBs by supergiant stars. .

The Transient High-Energy Sky and Early Universe Surveyor (THESEUS)

NASA Astrophysics Data System (ADS)

Amati, L.; O'Brien, P.; Goetz, D.; Tenzer, C.; Bozzo, E.

2017-10-01

The Transient High Energy Sky and Early Universe Surveyor (THESEUS) is a mission concept developed by a large international collaboration aimed at exploiting Gamma-Ray Bursts for investigating the early Universe. The main scientic objectives of THESEUS, currently under evaluation by ESA within the selection process for next M5 mission, include: investigating the star formation rate and metallicity evolution of the ISM and IGM up to redshift 10, detecting the first generation (pop III) of stars, studying the sources and physics of re-ionization, detecting the faint end of galaxies luminosity function. These goals will be achieved through a unique combination of instruments allowing GRB detection and arcmin localization over a broad FOV (more than 1sr) and an energy band extending from several MeVs down to 0.3 keV with unprecedented sensitivity, as well as on-board prompt (few minutes) follow-up with a 0.7m class IR telescope with both imaging and spectroscopic capabilities. Such instrumentation will also allow THESEUS to perform a monitoring of the X-ray sky with unprecedented sensitivity, which will provide a perfect service and sinergy to next generation multi-wavalength (e.g., E-ELT, SKA, CTA, ATHENA) and multi-messenger (aLIGO, aVIRGO, eLISA, ET, neutrino detectors, ...) facilities.

Search for GRB related prompt optical emission and other fast varying objects with ``Pi of the Sky'' detector

NASA Astrophysics Data System (ADS)

Ćwiok, M.; Dominik, W.; Małek, K.; Mankiewicz, L.; Mrowca-Ciułacz, J.; Nawrocki, K.; Piotrowski, L. W.; Sitek, P.; Sokołowski, M.; Wrochna, G.; Żarnecki, A. F.

2007-06-01

Experiment “Pi of the Sky” is designed to search for prompt optical emission from GRB sources. 32 CCD cameras covering 2 steradians will monitor the sky continuously. The data will be analysed on-line in search for optical flashes. The prototype with 2 cameras operated at Las Campanas (Chile) since 2004 has recognised several outbursts of flaring stars and has given limits for a few GRB.

Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions.

PubMed

Atabey, N; Gao, Y; Yao, Z J; Breckenridge, D; Soon, L; Soriano, J V; Burke, T R; Bottaro, D P

2001-04-27

Hepatocyte growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide range of cellular targets during development, homeostasis and tissue regeneration. Inappropriate HGF signaling occurs in several human cancers, and the ability of HGF to initiate a program of protease production, cell dissociation, and motility has been shown to promote cellular invasion and is strongly linked to tumor metastasis. Upon HGF binding, several tyrosines within the intracellular domain of its receptor, c-Met, become phosphorylated and mediate the binding of effector proteins, such as Grb2. Grb2 binding through its SH2 domain is thought to link c-Met with downstream mediators of cell proliferation, shape change, and motility. We analyzed the effects of Grb2 SH2 domain antagonists on HGF signaling and observed potent blockade of cell motility, matrix invasion, and branching morphogenesis, with ED(50) values of 30 nm or less, but only modest inhibition of mitogenesis. These compounds are 1000-10,000-fold more potent anti-motility agents than any previously characterized Grb2 SH2 domain antagonists. Our results suggest that SH2 domain-mediated c-Met-Grb2 interaction contributes primarily to the motogenic and morphogenic responses to HGF, and that these compounds may have therapeutic application as anti-metastatic agents for tumors where the HGF signaling pathway is active.

Activation of the JNK pathway is essential for transformation by the Met oncogene.

PubMed

Rodrigues, G A; Park, M; Schlessinger, J

1997-05-15

The Met/Hepatocyte Growth Factor (HGF) receptor tyrosine kinase is oncogenically activated through a rearrangement that creates a hybrid gene Tpr-Met. The resultant chimeric p65(Tpr-Met) protein is constitutively phosphorylated on tyrosine residues in vivo and associates with a number of SH2-containing signaling molecules including the p85 subunit of PI-3 kinase and the Grb2 adaptor protein, which couples receptor tyrosine kinases to the Ras signaling pathway. Mutation of the binding site for Grb2 impairs the ability of Tpr-Met oncoprotein to transform fibroblasts, suggesting that the activation of the Ras/MAP kinase signaling pathway through Grb2 may be essential for cellular transformation. To test this hypothesis dominant-negative mutants of Grb2 with deletions of the SH3 domains were introduced into Tpr-Met transformed fibroblasts. Cells overexpressing the mutants were found to be morphologically reverted and exhibited reduced growth in soft agar. Surprisingly, the Grb2 mutants blocked activation of the JNK/SAPK but not MAP kinase activity induced by the Tpr-Met oncoprotein. Additionally, cells expressing dominant-negative Grb2 mutants had reduced PI-3-kinase activity and dominant-negative mutants of Rac1 blocked both Tpr-Met-induced transformation and activation of JNK. These experiments reveal a novel link between Met and the JNK pathway, which is essential for transformation by this oncogene.

In brain, Axl recruits Grb2 and the p85 regulatory subunit of Pl3 kinase; in vitro mutagenesis defines th requisite binding sites for downstream Akt activation

PubMed Central

Weinger, Jason G.; Gohari, Pouyan; Yan, Ying; Backer, Jonathan M.; Varnum, Brian; Shafit-Zagardo, Bridget

2010-01-01

Axl is a receptor tyrosine kinase implicated in cell survival following growth factor withdrawal and other stressors. The binding of Axl's ligand, growth arrest-specific protein 6 (Gas6), results in Axl autophosphorylation, recruitment of signaling molecules, and activation of downstream survival pathways. Pull-down assays and immunoprecipitations using wildtype and mutant Axl transfected cells determined that Axl directly binds growth factor receptor-bound protein 2 (Grb2) at pYVN and the p85 subunit of phosphatidylinositol-3 kinase (PI3 kinase) at two pYXXM sites (pY779 and pY821). Also, p85 can indirectly bind to Axl via an interaction between p85's second proline-rich region and the N-terminal SH3 domain of Grb2. Further, Grb2 and p85 can compete for binding at the pY821VNM site. Gas6-stimulation of Axl-transfected COS7 cells recruited activated PI3 kinase and phosphorylated Akt. An interaction between Axl, p85 and Grb2 was confirmed in brain homogenates, enriched populations of O4+ oligodendrocytes, and O4– flow-through prepared from day 10 mouse brain, indicating that cells with active Gas6/Axl signal through Grb2 and the PI3 kinase/Akt pathways. PMID:18346204

Calibration of GRB Luminosity Relations with Cosmography

NASA Astrophysics Data System (ADS)

Gao, He; Liang, Nan; Zhu, Zong-Hong

For the use of gamma-ray bursts (GRBs) to probe cosmology in a cosmology-independent way, a new method has been proposed to obtain luminosity distances of GRBs by interpolating directly from the Hubble diagram of SNe Ia, and then calibrating GRB relations at high redshift. In this paper, following the basic assumption in the interpolation method that objects at the same redshift should have the same luminosity distance, we propose another approach to calibrate GRB luminosity relations with cosmographic fitting directly from SN Ia data. In cosmography, there is a well-known fitting formula which can reflect the Hubble relation between luminosity distance and redshift with cosmographic parameters which can be fitted from observation data. Using the Cosmographic fitting results from the Union set of SNe Ia, we calibrate five GRB relations using GRB sample at z ≤ 1.4 and deduce distance moduli of GRBs at 1.4 < z ≤ 6.6 by generalizing above calibrated relations at high redshift. Finally, we constrain the dark energy parameterization models of the Chevallier-Polarski-Linder (CPL) model, the Jassal-Bagla-Padmanabhan (JBP) model and the Alam model with GRB data at high redshift, as well as with the cosmic microwave background radiation (CMB) and the baryonic acoustic oscillation (BAO) observations, and we find the ΛCDM model is consistent with the current data in 1-σ confidence region.

Could GRB170817A be really correlated to an NS-NS merging?

NASA Astrophysics Data System (ADS)

Fargion, D.; Khlopov, M. Yu.; Oliva, P.

The exciting development of gravitational wave (GW) astronomy in the correlation of LIGO and VIRGO detection of GW signals makes possible to expect registration of effects of not only binary black hole (BH) coalescence but also binary neutron star (NS) merging accompanied by electromagnetic (gamma ray burst; GRB) signal. Here we consider the possibility that an NS, merging in an NS-NS or NS-BH system might be (soon) observed in correlation with any LIGO-VIRGO GWs detection. We analyze as an example the recent case of the short GRB170817A observed by Fermi and integral. The associated optical transient (OT) source in NGC4993 implies a rare near source, a consequent averaged large rate of such events (almost) compatible with expected NS-NS merging rate. However the expected beamed GRB (or short GRB) may be mostly aligned to a different direction than ours. Therefore, even soft GRB photons, spread more than hard ones, might be hardly able to shower to us. Nevertheless, a prompt spiraling electron turbine jet in largest magnetic fields, at the base of the NS-NS collapse, might shine by its tangential synchrotron radiation in spread way with its skimming photons shining in large open disk. The consequent solid angle for such soft disk gamma radiation may be large enough to be nevertheless often observed.

GRB070610: A Curious Galactic Transient

NASA Technical Reports Server (NTRS)

Kasliwal, M. M.; Kulkrarni. S. R.; Cameron, P. B.; Nakar, E.; Ofek, E. O.; Rau, A.; Soderberg, A. M.; Campana, S.; Bloom, J. S.; Perley, D. A.;

GRB 070610: A Curious Galactic Transient

NASA Astrophysics Data System (ADS)

Kasliwal, M. M.; Cenko, S. B.; Kulkarni, S. R.; Cameron, P. B.; Nakar, E.; Ofek, E. O.; Rau, A.; Soderberg, A. M.; Campana, S.; Bloom, J. S.; Perley, D. A.; Pollack, L. K.; Barthelmy, S.; Cummings, J.; Gehrels, N.; Krimm, H. A.; Markwardt, C. B.; Sato, G.; Chandra, P.; Frail, D.; Fox, D. B.; Price, P. A.; Berger, E.; Grebenev, S. A.; Krivonos, R. A.; Sunyaev, R. A.

2008-05-01

GRB 070610 is a typical high-energy event with a duration of 5 s. Yet within the burst localization we detect a highly unusual X-ray and optical transient, Swift J195509.6+261406. We see high-amplitude X-ray and optical variability on very short timescales even at late times. Using near-infrared imaging assisted by a laser guide star and adaptive optics, we identified the counterpart of Swift J195509.6+261406. Late-time optical and near-infrared imaging constrain the spectral type of the counterpart to be fainter than a K-dwarf, assuming it is of Galactic origin. It is possible that GRB 070610 and Swift J195509.6+261406 are unrelated sources. However, the absence of a typical X-ray afterglow from GRB 070610 in conjunction with the spatial and temporal coincidence of the two motivate us to suggest that the sources are related. The closest (imperfect) analog to Swift J195509.6+261406 is V4641 Sgr, an unusual black hole binary. We suggest that Swift J195509.6+261406 along with V4641 Sgr define a subclass of stellar black hole binaries—the fast X-ray novae. We further suggest that fast X-ray novae are associated with bursts of gamma rays. If so, GRB 070610 defines a new class of celestial gamma-ray bursts and these bursts dominate the long-duration GRB demographics.

Gamma-ray burst models.

PubMed

King, Andrew

2007-05-15

I consider various possibilities for making gamma-ray bursts, particularly from close binaries. In addition to the much-studied neutron star+neutron star and black hole+neutron star cases usually considered good candidates for short-duration bursts, there are also other possibilities. In particular, neutron star+massive white dwarf has several desirable features. These systems are likely to produce long-duration gamma-ray bursts (GRBs), in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation and occur close to the host galaxy. However, rare members of the class need not be near star-forming regions and could have any type of host galaxy. Thus, a long-duration burst far from any star-forming region would also be a signature of this class. Estimates based on the existence of a known progenitor suggest that this type of GRB may be quite common, in agreement with the fact that the absence of a supernova can only be established in nearby bursts.

A cross-correlation search for intermediate-duration gravitational waves from GRB magnetars

NASA Astrophysics Data System (ADS)

Coyne, Robert

2015-04-01

Since the discovery of the afterglow in 1997, the progress made in our understanding of gamma-ray bursts (GRBs) has been spectacular. Yet a direct proof of GRB progenitors is still missing. In the last few years, evidence for a long-lived and sustained central engine in GRBs has mounted. This has called attention to the so-called millisecond-magnetar model, which proposes that a highly magnetized, rapidly-rotating neutron star may exist at the heart of some of these events. The advent of advanced gravitational wave detectors such as LIGO and Virgo may enable us to probe directly, for the first time, the nature of GRB progenitors and their byproducts. In this context, we describe a novel application of a generalized cross-correlation technique optimized for the detection of long-duration gravitational wave signals that may be associated with bar-like deformations of GRB magnetars. The detection of these signals would allow us to answer some of the most intriguing questions on the nature of GRB progenitors, and serve as a starting point for a new class of intermediate-duration gravitational wave searches.

Prompt emission from the counter jet of a short gamma-ray burst

NASA Astrophysics Data System (ADS)

Yamazaki, Ryo; Ioka, Kunihito; Nakamura, Takashi

2018-03-01

The counter jet of a short gamma-ray burst (sGRB) has not yet been observed, while recent discoveries of gravitational waves (GWs) from a binary neutron star merger GW170817 and the associated sGRB 170817A have demonstrated that off-axis sGRB jets are detectable. We calculate the prompt emission from the counter jet of an sGRB and show that it is typically 23-26 mag in the optical-infrared band 10-10^3 s after the GWs for an sGRB 170817A-like event, which is brighter than the early macronova (or kilonova) emission and detectable by LSST in the near future. We also propose a new method to constrain the unknown jet properties, such as the Lorentz factor, opening angle, emission radii, and jet launch time, by observing both the forward and counter jets. To scrutinize the counter jets, space GW detectors like DECIGO are powerful in forecasting the merger time (≲ 1 s) and position (≲ 1 arcmin) (˜ a week) before the merger.

Implications for the Origin of GRB 051103 from LIGO Observations

NASA Astrophysics Data System (ADS)

Abadie, J.; Abbott, B. P.; Abbott, T. D.; Abbott, R.; Abernathy, M.; Adams, C.; Adhikari, R.; Affeldt, C.; Ajith, P.; Allen, B.; Allen, G. S.; Amador Ceron, E.; Amariutei, D.; Amin, R. S.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Arain, M. A.; Araya, M. C.; Aston, S. M.; Atkinson, D.; Aufmuth, P.; Aulbert, C.; Aylott, B. E.; Babak, S.; Baker, P.; Ballmer, S.; Barker, D.; Barnum, S.; Barr, B.; Barriga, P.; Barsotti, L.; Barton, M. A.; Bartos, I.; Bassiri, R.; Bastarrika, M.; Bauchrowitz, J.; Behnke, B.; Bell, A. S.; Belopolski, I.; Benacquista, M.; Bertolini, A.; Betzwieser, J.; Beveridge, N.; Beyersdorf, P. T.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Biswas, R.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Bland, B.; Bock, O.; Bodiya, T. P.; Bogan, C.; Bondarescu, R.; Bork, R.; Born, M.; Bose, S.; Boyle, M.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Breyer, J.; Bridges, D. O.; Brinkmann, M.; Britzger, M.; Brooks, A. F.; Brown, D. A.; Brummitt, A.; Buonanno, A.; Burguet-Castell, J.; Burmeister, O.; Byer, R. L.; Cadonati, L.; Camp, J. B.; Campsie, P.; Cannizzo, J.; Cannon, K.; Cao, J.; Capano, C.; Caride, S.; Caudill, S.; Cavaglia, M.; Cepeda, C.; Chalermsongsak, T.; Chalkley, E.; Charlton, P.; Chelkowski, S.; Chen, Y.; Christensen, N.; Chua, S. S. Y.; Chung, S.; Chung, C. T. Y.; Clara, F.; Clark, D.; Clark, J.; Clayton, J. H.; Conte, R.; Cook, D.; Corbitt, T. R. C.; Cornish, N.; Costa, C. A.; Coughlin, M.; Coward, D. M.; Coyne, D. C.; Creighton, J. D. E.; Creighton, T. D.; Cruise, A. M.; Cumming, A.; Cunningham, L.; Culter, R. M.; Dahl, K.; Danilishin, S. L.; Dannenberg, R.; Danzmann, K.; Das, K.; Daudert, B.; Daveloza, H.; Davies, G.; Daw, E. J.; Dayanga, T.; DeBra, D.; Degallaix, J.; Dent, T.; Dergachev, V.; DeRosa, R.; DeSalvo, R.; Dhurandhar, S.; Di Palma, I.; Díaz, M.; Donovan, F.; Dooley, K. L.; Dorsher, S.; Douglas, E. S. D.; Drever, R. W. P.; Driggers, J. C.; Dumas, J.-C.; Dwyer, S.; Eberle, T.; Edgar, M.; Edwards, M.; Effler, A.; Ehrens, P.; Engel, R.; Etzel, T.; Evans, M.; Evans, T.; Factourovich, M.; Fairhurst, S.; Fan, Y.; Farr, B. F.; Fazi, D.; Fehrmann, H.; Feldbaum, D.; Finn, L. S.; Flanigan, M.; Foley, S.; Forsi, E.; Fotopoulos, N.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Friedrich, D.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Garcia, J.; Garofoli, J. A.; Gholami, I.; Ghosh, S.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Gill, C.; Goetz, E.; Goggin, L. M.; González, G.; Gorodetsky, M. L.; Goßler, S.; Graef, C.; Grant, A.; Gras, S.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Grosso, R.; Grote, H.; Grunewald, S.; Guido, C.; Gupta, R.; Gustafson, E. K.; Gustafson, R.; Hage, B.; Hallam, J. M.; Hammer, D.; Hammond, G.; Hanks, J.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Hartman, M. T.; Haughian, K.; Hayama, K.; Heefner, J.; Hendry, M. A.; Heng, I. S.; Heptonstall, A. W.; Herrera, V.; Hewitson, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Holt, K.; Hong, T.; Hooper, S.; Hosken, D. J.; Hough, J.; Howell, E. J.; Hughey, B.; Husa, S.; Huttner, S. H.; Ingram, D. R.; Inta, R.; Isogai, T.; Ivanov, A.; Johnson, W. W.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kanner, J. B.; Katsavounidis, E.; Katzman, W.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Kelner, M.; Keppel, D. G.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, N.; Kim, H.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kondrashov, V.; Kopparapu, R.; Koranda, S.; Korth, W. Z.; Kozak, D.; Kringel, V.; Krishnamurthy, S.; Krishnan, B.; Kuehn, G.; Kumar, R.; Kwee, P.; Landry, M.; Lantz, B.; Lastzka, N.; Lazzarini, A.; Leaci, P.; Leong, J.; Leonor, I.; Li, J.; Lindquist, P. E.; Lockerbie, N. A.; Lodhia, D.; Lormand, M.; Lu, P.; Luan, J.; Lubinski, M.; Lück, H.; Lundgren, A. P.; Macdonald, E.; Machenschalk, B.; MacInnis, M.; Mageswaran, M.; Mailand, K.; Mandel, I.; Mandic, V.; Marandi, A.; Márka, S.; Márka, Z.; Maros, E.; Martin, I. W.; Martin, R. M.; Marx, J. N.; Mason, K.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McIntyre, G.; McIver, J.; McKechan, D. J. A.; Meadors, G.; Mehmet, M.; Meier, T.; Melatos, A.; Melissinos, A. C.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miao, H.; Miller, J.; Mino, Y.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Moe, B.; Moesta, P.; Mohanty, S. D.; Moraru, D.; Moreno, G.; Mossavi, K.; Mow-Lowry, C. M.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Müller-Ebhardt, H.; Munch, J.; Murphy, D.; Murray, P. G.; Nash, T.; Nawrodt, R.; Nelson, J.; Newton, G.; Nishizawa, A.; Nolting, D.; Nuttall, L.; O'Reilly, B.; O'Shaughnessy, R.; Ochsner, E.; O'Dell, J.; Ogin, G. H.; Oldenburg, R. G.; Osthelder, C.; Ott, C. D.; Ottaway, D. J.; Ottens, R. S.; Overmier, H.; Owen, B. J.; Page, A.; Pan, Y.; Pankow, C.; Papa, M. A.; Patel, P.; Pedraza, M.; Pekowsky, L.; Penn, S.; Peralta, C.; Perreca, A.; Phelps, M.; Pickenpack, M.; Pinto, I. M.; Pitkin, M.; Pletsch, H. J.; Plissi, M. V.; Podkaminer, J.; Pöld, J.; Postiglione, F.; Predoi, V.; Price, L. R.; Prijatelj, M.; Principe, M.; Privitera, S.; Prix, R.; Prokhorov, L.; Puncken, O.; Quetschke, V.; Raab, F. J.; Radkins, H.; Raffai, P.; Rakhmanov, M.; Ramet, C. R.; Rankins, B.; Mohapatra, S. R. P.; Raymond, V.; Redwine, K.; Reed, C. M.; Reed, T.; Reid, S.; Reitze, D. H.; Riesen, R.; Riles, K.; Roberts, P.; Robertson, N. A.; Robinson, C.; Robinson, E. L.; Roddy, S.; Rollins, J.; Romano, J. D.; Romie, J. H.; Röver, C.; Rowan, S.; Rüdiger, A.; Ryan, K.; Sakata, S.; Sakosky, M.; Salemi, F.; Salit, M.; Sammut, L.; Sancho de la Jordana, L.; Sandberg, V.; Sannibale, V.; Santamaría, L.; Santiago-Prieto, I.; Santostasi, G.; Saraf, S.; Sathyaprakash, B. S.; Sato, S.; Saulson, P. R.; Savage, R.; Schilling, R.; Schlamminger, S.; Schnabel, R.; Schofield, R. M. S.; Schulz, B.; Schutz, B. F.; Schwinberg, P.; Scott, J.; Scott, S. M.; Searle, A. C.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Sergeev, A.; Shaddock, D. A.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Shihan Weerathunga, T.; Shoemaker, D. H.; Sibley, A.; Siemens, X.; Sigg, D.; Singer, A.; Singer, L.; Sintes, A. M.; Skelton, G.; Slagmolen, B. J. J.; Slutsky, J.; Smith, R.; Smith, J. R.; Smith, M. R.; Smith, N. D.; Somiya, K.; Sorazu, B.; Soto, J.; Speirits, F. C.; Stein, A. J.; Steinlechner, J.; Steinlechner, S.; Steplewski, S.; Stefszky, M.; Stochino, A.; Stone, R.; Strain, K. A.; Strigin, S.; Stroeer, A. S.; Stuver, A. L.; Summerscales, T. Z.; Sung, M.; Susmithan, S.; Sutton, P. J.; Szokoly, G. P.; Talukder, D.; Tanner, D. B.; Tarabrin, S. P.; Taylor, J. R.; Taylor, R.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Thüring, A.; Tokmakov, K. V.; Torres, C.; Torrie, C. I.; Traylor, G.; Trias, M.; Tseng, K.; Ugolini, D.; Urbanek, K.; Vahlbruch, H.; Vaishnav, B.; Vallisneri, M.; Van Den Broeck, C.; van der Sluys, M. V.; van Veggel, A. A.; Vass, S.; Vaulin, R.; Vecchio, A.; Veitch, J.; Veitch, P. J.; Veltkamp, C.; Villar, A. E.; Vorvick, C.; Vyachanin, S. P.; Waldman, S. J.; Wallace, L.; Wanner, A.; Ward, R. L.; Wei, P.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wen, S.; Wessels, P.; West, M.; Westphal, T.; Wette, K.; Whelan, J. T.; Whitcomb, S. E.; White, D.; Whiting, B. F.; Wilkinson, C.; Willems, P. A.; Williams, H. R.; Williams, L.; Willke, B.; Winkelmann, L.; Winkler, W.; Wipf, C. C.; Wiseman, A. G.; Woan, G.; Wooley, R.; Worden, J.; Yablon, J.; Yakushin, I.; Yamamoto, K.; Yamamoto, H.; Yang, H.; Yeaton-Massey, D.; Yoshida, S.; Yu, P.; Zanolin, M.; Zhang, L.; Zhang, Z.; Zhao, C.; Zotov, N.; Zucker, M. E.; Zweizig, J.; LIGO Collaboration; Bizouard, M. A.; Dietz, A.; Guidi, G. M.; Was, M.

2012-08-01

We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst (GRB) whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6 Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at a distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed γ-ray emission with a jet semi-angle of 30°, we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with >99% confidence. If the event occurred in M81, then our findings support the hypothesis that GRB 051103 was due to an SGR giant flare, making it one of the most distant extragalactic magnetars observed to date.

Determining the Lorentz Factor and Viewing Angle of GRB 170817A

NASA Astrophysics Data System (ADS)

Zou, Yuan-Chuan; Wang, Fei-Fei; Moharana, Reetanjali; Liao, Bin; Chen, Wei; Wu, Qingwen; Lei, Wei-Hua; Wang, Fa-Yin

2018-01-01

The weak short gamma-ray burst (GRB) 170817A was accompanied by the GW170817 gravitational-wave event and is believed to have been produced by an off-beam relativistic jet. Here, we use the {E}{{p},{{i}}}{--}{E}{iso} and {{Γ }}{--}{E}{iso} relations to determine its Lorentz factor Γ and the viewing angle from the edge of the jet {θ }{obs}{\\prime } of GRB 170817A. Our results indicate that {{Γ }}={13.4}-5.5+9.8 and {θ }{obs}{\\prime }=4\\buildrel{\\circ}\\over{.} {3}-1.5+1.8, corresponding to an on-axis {E}{{p},{{i}}}={415}-167+361 {keV} and {E}{iso}=({2.4}-1.9+1.6)× {10}47 erg. Therefore, the GRB was an intrinsically weak short GRB. We also find that the afterglow emission was in good agreement with the follow-up multiband observations and that the radio emissions at around 20 days may have come from the off-axis jet. Interestingly, the Doppler factor and luminosity follow a universal relation for GRBs and blazars, thus suggesting that they may share a similar radiation mechanism.

FERMI observations of high-energy gamma-ray emission from GRB 090217A

DOE PAGES

Ackermann, M.; Ajello, M.; Baldini, L.; ...

2010-06-22

The Fermi observatory is advancing our knowledge of gamma-ray bursts (GRBs) through pioneering observations at high energies, covering more than seven decades in energy with the two on-board detectors, the Large Area Telescope (LAT) and the Gamma-ray Burst Monitor (GBM). Here, we report on the observation of the long GRB 090217A which triggered the GBM and has been detected by the LAT with a significance greater than 9σ. We present the GBM and LAT observations and on-ground analyses, including the time-resolved spectra and the study of the temporal profile from 8 keV up to ~1 GeV. All spectra are wellmore » reproduced by a Band model. We compare these observations to the first two LAT-detected, long bursts GRB 080825C and GRB 080916C. These bursts were found to have time-dependent spectra and exhibited a delayed onset of the high-energy emission, which are not observed in the case of GRB 090217A. We discuss some theoretical implications for the high-energy emission of GRBs.« less

The Gamma-Ray Burst ToolSHED is Open for Business

NASA Astrophysics Data System (ADS)

Giblin, Timothy W.; Hakkila, Jon; Haglin, David J.; Roiger, Richard J.

2004-09-01

The GRB ToolSHED, a Gamma-Ray Burst SHell for Expeditions in Data-Mining, is now online and available via a web browser to all in the scientific community. The ToolSHED is an online web utility that contains pre-processed burst attributes of the BATSE catalog and a suite of induction-based machine learning and statistical tools for classification and cluster analysis. Users create their own login account and study burst properties within user-defined multi-dimensional parameter spaces. Although new GRB attributes are periodically added to the database for user selection, the ToolSHED has a feature that allows users to upload their own burst attributes (e.g. spectral parameters, etc.) so that additional parameter spaces can be explored. A data visualization feature using GNUplot and web-based IDL has also been implemented to provide interactive plotting of user-selected session output. In an era in which GRB observations and attributes are becoming increasingly more complex, a utility such as the GRB ToolSHED may play an important role in deciphering GRB classes and understanding intrinsic burst properties.

Optical study of the counterpart to GRB 990712

NASA Astrophysics Data System (ADS)

Gorosabel, J.; Castro-Tirado, A. J.; Saizar, P.; Rattenbury, N. J.; Bond, I. A.; Yock, P.; Hearnshaw, J.; Kilmartin, P. M.; Muraki, Y.; Nakamura, T.; Ohnishi, K.; Reid, M.; Saito, To; Noda, S.

2000-09-01

Quasi-simultaneous BVR-band observations performed from New Zealand and Argentina ~16 hr after the burst clearly detected the optical counterpart to GR-B 990712. Based on these measurements we construct the optical multi-band spectrum. We report that the spectrum between the R and B bands follows a power law Fv~νβ with index β=-0.50+/-0.16. The spectrum is consistent with a stretch of an afterglow spectrum between the peak frequency, νm, and the cooling break, νc. The photon index derived following the model of Sari et al. (1998), p=2.36+/-0.08 is compatible with β and the power law decay, α, only if no absorption is introduced. Thus, our results support that GRB 990712 occurred in a low density region, resembling GRB 970508. .

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guiriec, S.; Kouveliotou, C.; Hartmann, D. H.

The origin of prompt emission from gamma-ray bursts (GRBs) remains to be an open question. Correlated prompt optical and γ -ray emission observed in a handful of GRBs strongly suggests a common emission region, but failure to adequately fit the broadband GRB spectrum prompted the hypothesis of different emission mechanisms for the low- and high-energy radiations. We demonstrate that our multi-component model for GRB γ -ray prompt emission provides an excellent fit to GRB 110205A from optical to γ -ray energies. Our results show that the optical and highest γ -ray emissions have the same spatial and spectral origin, whichmore » is different from the bulk of the X- and softest γ -ray radiation. Finally, our accurate redshift estimate for GRB 110205A demonstrates promise for using GRBs as cosmological standard candles.« less

Identification of GRB2 and GAB1 Coexpression as an Unfavorable Prognostic Factor for Hepatocellular Carcinoma by a Combination of Expression Profile and Network Analysis

PubMed Central

Yang, Mei; Wang, Danhua; Yu, Lingxiang; Guo, Chaonan; Guo, Xiaodong; Lin, Na

2013-01-01

Aim To screen novel markers for hepatocellular carcinoma (HCC) by a combination of expression profile, interaction network analysis and clinical validation. Methods HCC significant molecules which are differentially expressed or had genetic variations in HCC tissues were obtained from five existing HCC related databases (OncoDB.HCC, HCC.net, dbHCCvar, EHCO and Liverome). Then, the protein-protein interaction (PPI) network of these molecules was constructed. Three topological features of the network ('Degree', 'Betweenness', and 'Closeness') and the k-core algorithm were used to screen candidate HCC markers which play crucial roles in tumorigenesis of HCC. Furthermore, the clinical significance of two candidate HCC markers growth factor receptor-bound 2 (GRB2) and GRB2-associated-binding protein 1 (GAB1) was validated. Results In total, 6179 HCC significant genes and 977 HCC significant proteins were collected from existing HCC related databases. After network analysis, 331 candidate HCC markers were identified. Especially, GAB1 has the highest k-coreness suggesting its central localization in HCC related network, and the interaction between GRB2 and GAB1 has the largest edge-betweenness implying it may be biologically important to the function of HCC related network. As the results of clinical validation, the expression levels of both GRB2 and GAB1 proteins were significantly higher in HCC tissues than those in their adjacent nonneoplastic tissues. More importantly, the combined GRB2 and GAB1 protein expression was significantly associated with aggressive tumor progression and poor prognosis in patients with HCC. Conclusion This study provided an integrative analysis by combining expression profile and interaction network analysis to identify a list of biologically significant HCC related markers and pathways. Further experimental validation indicated that the aberrant expression of GRB2 and GAB1 proteins may be strongly related to tumor progression and prognosis in patients with HCC. The overexpression of GRB2 in combination with upregulation of GAB1 may be an unfavorable prognostic factor for HCC. PMID:24391994

Chandra Observations of the X-Ray Environs of SN 1998BW / GRB 980425

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kouveliotou , C.

2004-07-14

We report X-ray studies of the environs of SN 1998bw and GRB 980425 using the Chandra X-Ray Observatory 1281 days after the GRB. Eight X-ray point sources were localized, three and .ve each in the original error boxes--S1 and S2--assigned for variable X-ray counterparts to the GRB by BeppoSAX. The sum of the discrete X-ray sources plus continuous emission in S2 observed by CXO on day 1281 is within a factor of 1.5 of the maximum and the upper limits seen by BeppoSAX. We conclude that S2 is the sum of several variable sources that have not disappeared, and thereforemore » is not associated with the GRB. Within S1, clear evidence is seen for a decline of approximately a factor of 12 between day 200 and day 1281. One of the sources in S1, S1a, is coincident with the well-determined radio location of SN 1998bw, and is certainly the remnant of that explosion. The nature of the other sources is also discussed. Combining our observation of the supernova with others of the GRB afterglow, a smooth X-ray light curve, spanning {approx} 1300 days, is obtained by assuming the burst and supernova were coincident at 35.6 Mpc. When this X-ray light curve is compared with those of the X-ray ''afterglows'' of ordinary GRBs, X-ray Flashes, and ordinary supernovae, evidence emerges for at least two classes of lightcurves, perhaps bounding a continuum. By three to ten years, all these phenomena seem to converge on a common X-ray luminosity, possibly indicative of the supernova underlying them all. This convergence strengthens the conclusion that SN 1998bw and GRB 980425 took place in the same object. One possible explanation for the two classes is a (nearly) standard GRB observed at different angles, in which case X-ray afterglows with intermediate luminosities should eventually be discovered. Finally, we comment on the contribution of GRBs to the ULX source population.« less

Overview of the SVOM Gamma-Ray Burst mission under development with a focus on its Trigger system

NASA Astrophysics Data System (ADS)

Schanne, Stephane

2017-08-01

The SVOM mission (Space-based Variable Objects Monitor) is a Chinese-French satellite mission under development, devoted to collecting a complete sample of Gamma-Ray Bursts (GRBs) observed at multi-wavelengths with a high fraction of redshift determinations. In January 2017 the mission entered Phase C, starting officially construction, and the launch is foreseen in 2021. The SVOM satellite is equipped with 4 instruments, 2 of which cover the prompt GRB phase. The ECLAIRs coded-mask imager surveys a 2-sr large portion of the sky in the 4-150 keV energy range, well suited for the detection of X-ray rich and highly redshifted GRBs. The ECLAIRs trigger system continuously searches for GRBs using two algorithms, a count-rate trigger for short time scales and an image trigger for long time scales. In case of a localized new GRB candidate or a bright outburst of a known source, it promptly requests a satellite slew and sends an alert to ground. The onboard GRM (Gamma-Ray Monitor) extends the prompt energy coverage up to 5 MeV. After slew, 2 more onboard instruments study the GRB afterglow and refine the GRB localization: the MXT (Multi-pore optics X-ray Telescope) and the VT (Visible Telescope). Two types of ground telescopes are dedicated to SVOM. The GFTs (Ground Follow-up Telescopes) repoint autonomously to GRB alerts, refine their localization and provide photometric redshift. The SVOM observing strategy with roughly antisolar pointing combined with Galactic plane avoidance, ensures that most GRBs are quickly visible by the GFTs and large spectroscopic telescopes. The GWAC (Ground Wide Angle Camera) will observe the sky simultaneously with ECLAIRs to detect prompt optical GRB emissions. Today part of the GWAC is already operational. The SVOM GRB program is complemented by pre-planned target observations and ground-commanded targets of opportunity, e.g. to search for electromagnetic counterparts of gravity-wave events. On behalf of the SVOM and ECLAIRs teams, this paper presents an overview of SVOM with a focus on its GRB trigger system.

Pi of the Sky observation of GRB160625B

NASA Astrophysics Data System (ADS)

Opiela, Rafał; Batsch, Tadeusz; Castro-Tirado, Alberto Javier; Czyrkowski, Henryk; Ćwiek, Arkadiusz; Ćwiok, Mikołaj; DÄ browski, Ryszard; Jelinek, Martin; Kasprowicz, Grzegorz; Majcher, Ariel; Małek, Katarzyna; Mankiewicz, Lech; Nawrocki, Krzysztof; Obara, Łukasz; Piotrowski, Lech; Siudek, Małgorzata; Sokołowski, Marcin; Wawrzaszek, Roman; Wrochna, Grzegorz; Zaremba, Marcin; Żarnecki, Aleksander Filip

2017-08-01

Pi of the Sky is a system of wide field of view robotic telescopes, which search for short timescale astrophysical phenomena, especially for prompt optical GRB emission. The system was designed for autonomous operation, monitoring a large fraction of the sky to a depth of 12m-13m and with time resolution of the order of 10 seconds. Custom designed CCD cameras are equipped with Canon lenses f = 85 mm, f/d = 1.2 and cover 20° × 20° of the sky each. The final system with 16 cameras on 4 equatorial mounts was completed in 2014 at the INTA El Arenosillo Test Centre in Spain. GRB160625B was an extremely bright GRB with three distinct emission episodes. Cameras of the Pi of the Sky observatory in Spain were not observing the position of the GRB160625B prior to the first emission episode. Observations started only after receiving Fermi/GBM trigger, about 140 seconds prior to the second emission. As the position estimate taken from the Fermi alert and used to position the telescope was not very accurate, the actual position of the burst happened to be in the overlap region of two cameras, resulting in two independent sets of measurements. Light curves from both cameras were reconstructed using the Luiza framework. No object brighter than 12.4m (3σ limit) was observed prior to the second GRB emission. An optical flash was identified on an image starting -5.9s before the time of the Fermi/LAT trigger, brightening to about 8m on the next image and then becoming gradually dimmer, fading below our sensitivity after about 400s. Emission features as measured in different spectral bands indicate that the three emission episodes of GRB160625B were dominated by distinct physics process. Simultaneously observations in gamma-rays and optical wavelengths support the hypothesis that this was the first observed transition from thermal to non-thermal radiation in a single GRB. Main results of the combined analysis are presented.

Host galaxy identification for supernova surveys

DOE PAGES

Gupta, Ravi R.; Kuhlmann, Steve; Kovacs, Eve; ...

2016-11-08

Host galaxy identification is a crucial step for modern supernova (SN) surveys such as the Dark Energy Survey (DES) and the Large Synoptic Survey Telescope (LSST), which will discover SNe by the thousands. Spectroscopic resources are limited, so in the absence of real-time SN spectra these surveys must rely on host galaxy spectra to obtain accurate redshifts for the Hubble diagram and to improve photometric classification of SNe. In addition, SN luminosities are known to correlate with host-galaxy properties. Therefore, reliable identification of host galaxies is essential for cosmology and SN science. We simulate SN events and their locations withinmore » their host galaxies to develop and test methods for matching SNe to their hosts. We use both real and simulated galaxy catalog data from the Advanced Camera for Surveys General Catalog and MICECATv2.0, respectively. We also incorporate "hostless" SNe residing in undetected faint hosts into our analysis, with an assumed hostless rate of 5%. Our fully automated algorithm is run on catalog data and matches SNe to their hosts with 91% accuracy. We find that including a machine learning component, run after the initial matching algorithm, improves the accuracy (purity) of the matching to 97% with a 2% cost in efficiency (true positive rate). Although the exact results are dependent on the details of the survey and the galaxy catalogs used, the method of identifying host galaxies we outline here can be applied to any transient survey.« less

HOST GALAXY IDENTIFICATION FOR SUPERNOVA SURVEYS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Ravi R.; Kuhlmann, Steve; Kovacs, Eve

Host galaxy identification is a crucial step for modern supernova (SN) surveys such as the Dark Energy Survey and the Large Synoptic Survey Telescope, which will discover SNe by the thousands. Spectroscopic resources are limited, and so in the absence of real-time SN spectra these surveys must rely on host galaxy spectra to obtain accurate redshifts for the Hubble diagram and to improve photometric classification of SNe. In addition, SN luminosities are known to correlate with host-galaxy properties. Therefore, reliable identification of host galaxies is essential for cosmology and SN science. We simulate SN events and their locations within theirmore » host galaxies to develop and test methods for matching SNe to their hosts. We use both real and simulated galaxy catalog data from the Advanced Camera for Surveys General Catalog and MICECATv2.0, respectively. We also incorporate “hostless” SNe residing in undetected faint hosts into our analysis, with an assumed hostless rate of 5%. Our fully automated algorithm is run on catalog data and matches SNe to their hosts with 91% accuracy. We find that including a machine learning component, run after the initial matching algorithm, improves the accuracy (purity) of the matching to 97% with a 2% cost in efficiency (true positive rate). Although the exact results are dependent on the details of the survey and the galaxy catalogs used, the method of identifying host galaxies we outline here can be applied to any transient survey.« less

Host galaxy identification for supernova surveys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Ravi R.; Kuhlmann, Steve; Kovacs, Eve

Host galaxy identification is a crucial step for modern supernova (SN) surveys such as the Dark Energy Survey (DES) and the Large Synoptic Survey Telescope (LSST), which will discover SNe by the thousands. Spectroscopic resources are limited, so in the absence of real-time SN spectra these surveys must rely on host galaxy spectra to obtain accurate redshifts for the Hubble diagram and to improve photometric classification of SNe. In addition, SN luminosities are known to correlate with host-galaxy properties. Therefore, reliable identification of host galaxies is essential for cosmology and SN science. We simulate SN events and their locations withinmore » their host galaxies to develop and test methods for matching SNe to their hosts. We use both real and simulated galaxy catalog data from the Advanced Camera for Surveys General Catalog and MICECATv2.0, respectively. We also incorporate "hostless" SNe residing in undetected faint hosts into our analysis, with an assumed hostless rate of 5%. Our fully automated algorithm is run on catalog data and matches SNe to their hosts with 91% accuracy. We find that including a machine learning component, run after the initial matching algorithm, improves the accuracy (purity) of the matching to 97% with a 2% cost in efficiency (true positive rate). Although the exact results are dependent on the details of the survey and the galaxy catalogs used, the method of identifying host galaxies we outline here can be applied to any transient survey.« less

HOST GALAXY IDENTIFICATION FOR SUPERNOVA SURVEYS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Ravi R.; Kuhlmann, Steve; Kovacs, Eve

Host galaxy identification is a crucial step for modern supernova (SN) surveys such as the Dark Energy Survey and the Large Synoptic Survey Telescope, which will discover SNe by the thousands. Spectroscopic resources are limited, and so in the absence of real-time SN spectra these surveys must rely on host galaxy spectra to obtain accurate redshifts for the Hubble diagram and to improve photometric classification of SNe. In addition, SN luminosities are known to correlate with host-galaxy properties. Therefore, reliable identification of host galaxies is essential for cosmology and SN science. We simulate SN events and their locations within theirmore » host galaxies to develop and test methods for matching SNe to their hosts. We use both real and simulated galaxy catalog data from the Advanced Camera for Surveys General Catalog and MICECATv2.0, respectively. We also incorporate "hostless" SNe residing in undetected faint hosts into our analysis, with an assumed hostless rate of 5%. Our fully automated algorithm is run on catalog data and matches SNe to their hosts with 91% accuracy. We find that including a machine learning component, run after the initial matching algorithm, improves the accuracy (purity) of the matching to 97% with a 2% cost in efficiency (true positive rate). Although the exact results are dependent on the details of the survey and the galaxy catalogs used, the method of identifying host galaxies we outline here can be applied to any transient survey.« less

HAPPY BIRTHDAY SWIFT: ULTRA-LONG GRB 141121A AND ITS BROADBAND AFTERGLOW

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cucchiara, A.; Veres, P.; Corsi, A.

2015-10-20

We present our extensive observational campaign on the Swift-discovered GRB 141121A, almost 10 years after its launch. Our observations cover radio through X-rays and extend for more than 30 days after discovery. The prompt phase of GRB 141121A lasted 1410 s and, at the derived redshift of z = 1.469, the isotropic energy is E{sub γ,iso} = 8.0 × 10{sup 52} erg. Due to the long prompt duration, GRB 141121A falls into the recently discovered class of ultra-long GRBs (UL-GRBs). Peculiar features of this burst are (1) a flat early-time optical light curve and (2) a radio-to-X-ray rebrightening around threemore » days after the burst. The latter is followed by a steep optical-to-X-ray decay and a much shallower radio fading. We analyze GRB 141121A in the context of the standard forward–reverse shock (FS, RS) scenario and we disentangle the FS and RS contributions. Finally, we comment on the puzzling early-time (t ≲ 3 days) behavior of GRB 141121A, and suggest that its interpretation may require a two-component jet model. Overall, our analysis confirms that the class of UL-GRBs represents our best opportunity to firmly establish the prominent emission mechanisms in action during powerful gamma-ray burst explosions, and future missions (like SVOM, XTiDE, or ISS-Lobster) will provide many more of such objects.« less

The GW170817/GRB 170817A/AT 2017gfo Association: Some Implications for Physics and Astrophysics

NASA Astrophysics Data System (ADS)

Wang, Hao; Zhang, Fu-Wen; Wang, Yuan-Zhu; Shen, Zhao-Qiang; Liang, Yun-Feng; Li, Xiang; Liao, Neng-Hui; Jin, Zhi-Ping; Yuan, Qiang; Zou, Yuan-Chuan; Fan, Yi-Zhong; Wei, Da-Ming

2017-12-01

On 2017 August 17, a gravitational-wave event (GW170817) and an associated short gamma-ray burst (GRB 170817A) from a binary neutron star merger had been detected. The follow-up optical/infrared observations also identified the macronova/kilonova emission (AT 2017gfo). In this work, we discuss some implications of the remarkable GW170817/GRB 170817A/AT 2017gfo association. We show that the ∼1.7 s time delay between the gravitational-wave (GW) and GRB signals imposes very tight constraints on the superluminal movement of gravitational waves (i.e., the relative departure of GW velocity from the speed of light is ≤slant 4.3× {10}-16) or the possible violation of the weak equivalence principle (i.e., the difference of the gamma-ray and GW trajectories in the gravitational field of the galaxy and the local universe should be within a factor of ∼ 3.4× {10}-9). The so-called Dark Matter Emulators and a class of contender models for cosmic acceleration (“Covariant Galileon”) are ruled out as well. The successful identification of lanthanide elements in the macronova/kilonova spectrum also excludes the possibility that the progenitors of GRB 170817A are a binary strange star system. The high neutron star merger rate (inferred from both the local sGRB data and the gravitational-wave data) together with the significant ejected mass strongly suggest that such mergers are the prime sites of heavy r-process nucleosynthesis.

New 40Ar/ 39Ar dating of the Grande Ronde lavas, Columbia River Basalts, USA: Implications for duration of flood basalt eruption episodes

NASA Astrophysics Data System (ADS)

Barry, T. L.; Self, S.; Kelley, S. P.; Reidel, S.; Hooper, P.; Widdowson, M.

2010-08-01

Grande Ronde Basalt (GRB) lavas represent the most voluminous eruptive pulse of the Columbia River-Snake River-Yellowstone hotspot volcanism. With an estimated eruptive volume of 150,000 km 3, GRB lavas form at least 66% of the total volume of the Columbia River Basalt Group. New 40Ar/ 39Ar dates for GRB lavas reveal they were emplaced within a maximum period of 0.42 ± 0.18 My. A well-documented stratigraphy indicates at least 110 GRB flow fields (or individual eruptions), and on this basis suggests an average inter-eruption hiatus of less than 4000 years. Isotopic age-dating cannot resolve time gaps between GRB eruptions, and it is difficult to otherwise form a picture of the durations of eruptions because of non-uniform weathering in the top of flow fields and a general paucity of sediments between GR lavas. Where sediment has formed on top of GRB lavas, it varies in thickness from zero to 20-30 cm of silty to fine-sandy material, with occasional diatomaceous sediment. Individual GRB eruptions varied considerably in volume but many were greater than 1000 km 3 in size. Most probably eruptive events were not equally spaced in time; some eruptions may have followed short periods of volcanic repose (perhaps 10 2 to 10 3 of years), whilst others could have been considerably longer (many 1000 s to > 10 4 years). Recent improvements in age-dating for other continental flood basalt (CFB) lava sequences have yielded estimates of total eruptive durations of less than 1 My for high-volume pulses of lava production. The GRB appears to be a similar example, where the main pulse occupied a brief period. Even allowing for moderate to long-duration pahoehoe flow field production, the amount of time the system spends in active lava-producing mode is small — less than c. 2.6% (based on eruption durations of approximately 10,000 years, compared to the duration of the entire eruptive pulse of c. 420,000 years). A review of available 40Ar/ 39Ar data for the major voluminous phases of the Columbia River Basalt Group suggests that activity of the Steens Basalt-Imnaha Basalt-GRB may have, at times, been simultaneous, with obvious implications for climatic effects. Resolving intervals between successive eruptions during CFB province construction, and durations of main eruptive pulses, remains vital to determining the environmental impact of these huge eruptions.

Wind-Interaction Models for the Early Afterglows of Gamma-Ray Bursts: The Case of GRB 021004

NASA Astrophysics Data System (ADS)

Li, Zhi-Yun; Chevalier, Roger A.

2003-06-01

Wind-interaction models for gamma-ray burst (GRB) afterglows predict that the optical emission from the reverse shock drops below that from the forward shock within hundreds of seconds of the burst. The typical frequency νm of the synchrotron emission from the forward shock passes through the optical band typically on a timescale of minutes to hours. Before the passage of νm, the optical flux evolves as t-1/4, and after the passage, the decay steepens to t-(3p-2)/4, where p is the exponent for the assumed power-law energy distribution of nonthermal electrons and is typically ~2. The steepening in the slope of temporal decay should be readily identifiable in the early afterglow light curves. We propose that such a steepening was observed in the R-band light curve of GRB 021004 around day 0.1. Available data at several radio frequencies are consistent with this interpretation, as are the X-ray observations around day 1. The early evolution of GRB 021004 contrasts with that of GRB 990123, which can be described by emission from interaction with a constant density medium.

Photospheric Emission in the Joint GBM and Konus Prompt Spectra of GRB 120323A

NASA Technical Reports Server (NTRS)

Guiriec, S.; Gehrels, N.; McEnery, J.; Kouveliotou, C.; Hartmann, D. H.

2017-01-01

GRB 120323A is a very intense short gamma-ray burst (GRB) detected simultaneously during its prompt gamma-ray emission phase with the Gamma-Ray Burst Monitor (GBM) on board the Fermi Gamma-Ray Space Telescope and the Konus experiment on board the Wind satellite. GBM and Konus operate in the kiloelectronvolt - megaelectronvolt regime; however, the GBM range is broader toward both the low and the high parts of the gamma-ray spectrum. Analyses of such bright events provide a unique opportunity to check the consistency of the data analysis as well as cross-calibrate the two instruments. We performed time-integrated and coarse time-resolved spectral analysis of GRB 120323A prompt emission. We conclude that the analyses of GBM and Konus data are only consistent when using a double-hump spectral shape for both data sets; in contrast, the single hump of the empirical Band function, traditionally used to fit GRB prompt emission spectra, leads to significant discrepancies between GBM and Konus analysis results. Our two-hump model is a combination of a thermal-like and a non-thermal component. We interpret the first component as a natural manifestation of the jet photospheric emission.

TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages

PubMed Central

Haidar, Malak; Whitworth, Jessie; Noé, Gaelle; Liu, Wang Qing; Vidal, Michel; Langsley, Gordon

2015-01-01

Theileria-infected macrophages display many features of cancer cells such as heightened invasive capacity; however, the tumor-like phenotype is reversible by killing the parasite. Moreover, virulent macrophages can be attenuated by multiple in vitro passages and so provide a powerful model to elucidate mechanisms related to transformed macrophage virulence. Here, we demonstrate that in two independent Theileria-transformed macrophage cell lines Grb2 expression is down-regulated concomitant with loss of tumor virulence. Using peptidimer-c to ablate SH2 and SH3 interactions of Grb2 we identify TGF-receptor II and the p85 subunit of PI3-K, as Grb2 partners in virulent macrophages. Ablation of Grb2 interactions reduces PI3-K recruitment to TGF-RII and decreases PIP3 production, and dampens JNK phosphorylation and AP-1-driven transcriptional activity down to levels characteristic of attenuated macrophages. Loss of TGF-R>PI3-K>JNK>AP-1 signaling negatively impacts on virulence traits such as reduced JAM-L/ITG4A and Fos-B/MMP9 expression that contribute to virulent macrophage adhesion and invasiveness. PMID:26511382

UFFO/ Lomonosov: The Payload for the Observation of Early Photons from Gamma Ray Bursts

NASA Astrophysics Data System (ADS)

Park, I. H.; Panasyuk, M. I.; Reglero, V.; Chen, P.; Castro-Tirado, A. J.; Jeong, S.; Bogomolov, V.; Brandt, S.; Budtz-Jørgensen, C.; Chang, S.-H.; Chang, Y. Y.; Chen, C.-R.; Chen, C.-W.; Choi, H. S.; Connell, P.; Eyles, C.; Gaikov, G.; Garipov, G.; Huang, J.-J.; Huang, M.-H. A.; Jeong, H. M.; Kim, J. E.; Kim, M. B.; Kim, S.-W.; Lee, H. K.; Lee, J.; Lim, H.; Lin, C.-Y.; Liu, T.-C.; Nam, J. W.; Petrov, V.; Ripa, J.; Rodrigo, J. M.; Svertilov, S.; Wang, M.-Z.; Yashin, I.

2018-02-01

The payload of the UFFO (Ultra-Fast Flash Observatory)-pathfinder now onboard the Lomonosov spacecraft (hereafter UFFO/ Lomonosov) is a dedicated instrument for the observation of GRBs. Its primary aim is to capture the rise phase of the optical light curve, one of the least known aspects of GRBs. Fast response measurements of the optical emission of GRB will be made by a Slewing Mirror Telescope (SMT), a key instrument of the payload, which will open a new frontier in transient studies by probing the early optical rise of GRBs with a response time in seconds for the first time. The SMT employs a rapidly slewing mirror to redirect the optical axis of the telescope to a GRB position prior determined by the UFFO Burst Alert Telescope (UBAT), the other onboard instrument, for the observation and imaging of X-rays. UFFO/Lomonosov was launched successfully from Vostochny, Russia on April 28, 2016, and will begin GRB observations after completion of functional checks of the Lomonosov spacecraft. The concept of early GRB photon measurements with UFFO was reported in 2012. In this article, we will report in detail the first mission, UFFO/Lomonosov, for the rapid response to GRB observations.

X-Ray Spectral Diagnostics of Gamma-Ray Burst Environments.

PubMed

Paerels; Kuulkers; Heise; Liedahl

2000-05-20

Recently, detection of discrete features in the X-ray afterglow spectra of GRB 970508 and GRB 970828 was reported. The most natural interpretation of these features is that they are redshifted Fe K emission complexes. The identification of the line emission mechanism has drastic implications for the inferred mass of radiating material and hence the nature of the burst site. X-ray spectroscopy provides a direct observational constraint on these properties of gamma-ray bursters. We briefly discuss how these constraints arise in the context of an application to the spectrum of GRB 970508.

GCN and VOEvent - A Status Report

NASA Technical Reports Server (NTRS)

Barthelmy, Scott

2006-01-01

The GRB Coordinates Network (GCN) has filled an important niche in the conduct and progress of research on GRB for more than 14 years. The methods used to collect and distribute the positions, lightcurves, spectra, and images on GRB is real time (a few seconds) will be reviewed. For the research on GRBs to continue to move forward and for other fields of transient astronomy to move forward, enhancements are needed to the GCN. VOEvents is one of those changes, and that addition will be described here. The enhanced system will be called VO-GCN.

Growth Factor Receptor–Bound Protein 2 Contributes to (Hem)Immunoreceptor Tyrosine-Based Activation Motif–Mediated Signaling in Platelets

PubMed Central

Morowski, Martina; Schiessl, Sarah; Schäfer, Carmen M.; Watson, Stephanie K.; Hughes, Craig E.; Ackermann, Jochen A.; Radtke, Daniel; Hermanns, Heike M.; Watson, Steve P.; Nitschke, Lars; Nieswandt, Bernhard

2015-01-01

Rationale Platelets are anuclear cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity but may also cause pathological vessel occlusion. One major pathway of platelet activation is triggered by 2 receptors that signal through an (hem)immunoreceptor tyrosine-based activation motif (ITAM), the activating collagen receptor glycoprotein (GP) VI and the C-type lectin-like receptor 2 (CLEC-2). Growth factor receptor–bound protein 2 (Grb2) is a ubiquitously expressed adapter molecule involved in signaling processes of numerous receptors in different cell types, but its function in platelets and MKs is unknown. Objective We tested the hypothesis that Grb2 is a crucial adapter protein in (hem)immunoreceptor tyrosine-based activation motif signaling in platelets. Methods and Results Here, we show that genetic ablation of Grb2 in MKs and platelets did not interfere with MK differentiation or platelet production. However, Grb2-deficiency severely impaired glycoprotein VI–mediated platelet activation because of defective stabilization of the linker of activated T-cell (LAT) signalosome and activation of downstream signaling proteins that resulted in reduced adhesion, aggregation, and coagulant activity on collagen in vitro. Similarly, CLEC-2–mediated signaling was impaired in Grb2-deficient platelets, whereas the cells responded normally to stimulation of G protein–coupled receptors. In vivo, this selective (hem) immunoreceptor tyrosine-based activation motif signaling defect resulted in prolonged bleeding times but affected arterial thrombus formation only after concomitant treatment with acetylsalicylic acid, indicating that defective glycoprotein VI signaling in the absence of Grb2 can be compensated through thromboxane A2–induced G protein–coupled receptor signaling pathways. Conclusions These results reveal an important contribution of Grb2 in (hem)immunoreceptor tyrosine-based activation motif signaling in platelets in hemostasis and thrombosis by stabilizing the LAT signalosome. PMID:24265393

The supercritical pile gamma-ray burst model: The GRB afterglow steep decline and plateau phase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sultana, J.; Kazanas, D.; Mastichiadis, A., E-mail: joseph.sultana@um.edu.mt

2013-12-10

We present a process that accounts for the steep decline and plateau phase of the Swift X-Ray Telescope (XRT) light curves, vexing features of gamma-ray burst (GRB) phenomenology. This process is an integral part of the 'supercritical pile' GRB model, proposed a few years ago to account for the conversion of the GRB kinetic energy into radiation with a spectral peak at E {sub pk} ∼ m{sub e}c {sup 2}. We compute the evolution of the relativistic blast wave (RBW) Lorentz factor Γ to show that the radiation-reaction force due to the GRB emission can produce an abrupt, small (∼25%)more » decrease in Γ at a radius that is smaller (depending on conditions) than the deceleration radius R{sub D} . Because of this reduction, the kinematic criticality criterion of the 'supercritical pile' is no longer fulfilled. Transfer of the proton energy into electrons ceases and the GRB enters abruptly the afterglow phase at a luminosity smaller by ∼m{sub p} /m{sub e} than that of the prompt emission. If the radius at which this slow-down occurs is significantly smaller than R{sub D} , the RBW internal energy continues to drive the RBW expansion at a constant (new) Γ and its X-ray luminosity remains constant until R{sub D} is reached, at which point it resumes its more conventional decay, thereby completing the 'unexpected' XRT light curve phase. If this transition occurs at R ≅ R{sub D} , the steep decline is followed by a flux decrease instead of a 'plateau,' consistent with the conventional afterglow declines. Besides providing an account of these peculiarities, the model suggests that the afterglow phase may in fact begin before the RBW reaches R ≅ R{sub D} , thus providing novel insights into GRB phenomenology.« less

The Supercritical Pile Gamma-Ray Burst Model: The GRB Afterglow Steep Decline and Plateau Phase

NASA Technical Reports Server (NTRS)

Sultana, Joseph; Kazanas, D.; Mastichiadis, A.

2013-01-01

We present a process that accounts for the steep decline and plateau phase of the Swift X-Ray Telescope (XRT) light curves, vexing features of gamma-ray burst (GRB) phenomenology. This process is an integral part of the "supercritical pile" GRB model, proposed a few years ago to account for the conversion of the GRB kinetic energy into radiation with a spectral peak at E(sub pk) is approx. m(sub e)C(exp 2). We compute the evolution of the relativistic blast wave (RBW) Lorentz factor Gamma to show that the radiation-reaction force due to the GRB emission can produce an abrupt, small (approx. 25%) decrease in Gamma at a radius that is smaller (depending on conditions) than the deceleration radius R(sub D). Because of this reduction, the kinematic criticality criterion of the "supercritical pile" is no longer fulfilled. Transfer of the proton energy into electrons ceases and the GRB enters abruptly the afterglow phase at a luminosity smaller by approx. m(sub p)/m(sub e) than that of the prompt emission. If the radius at which this slow-down occurs is significantly smaller than R(sub D), the RBW internal energy continues to drive the RBW expansion at a constant (new) Gamma and its X-ray luminosity remains constant until R(sub D) is reached, at which point it resumes its more conventional decay, thereby completing the "unexpected" XRT light curve phase. If this transition occurs at R is approx. equal to R(sub D), the steep decline is followed by a flux decrease instead of a "plateau," consistent with the conventional afterglow declines. Besides providing an account of these peculiarities, the model suggests that the afterglow phase may in fact begin before the RBW reaches R is approx. equal to R(sub D), thus providing novel insights into GRB phenomenology.

An Artificial Intelligence Classification Tool and Its Application to Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Hakkila, Jon; Haglin, David J.; Roiger, Richard J.; Giblin, Timothy; Paciesas, William S.; Pendleton, Geoffrey N.; Mallozzi, Robert S.

2004-01-01

Despite being the most energetic phenomenon in the known universe, the astrophysics of gamma-ray bursts (GRBs) has still proven difficult to understand. It has only been within the past five years that the GRB distance scale has been firmly established, on the basis of a few dozen bursts with x-ray, optical, and radio afterglows. The afterglows indicate source redshifts of z=1 to z=5, total energy outputs of roughly 10(exp 52) ergs, and energy confined to the far x-ray to near gamma-ray regime of the electromagnetic spectrum. The multi-wavelength afterglow observations have thus far provided more insight on the nature of the GRB mechanism than the GRB observations; far more papers have been written about the few observed gamma-ray burst afterglows in the past few years than about the thousands of detected gamma-ray bursts. One reason the GRB central engine is still so poorly understood is that GRBs have complex, overlapping characteristics that do not appear to be produced by one homogeneous process. At least two subclasses have been found on the basis of duration, spectral hardness, and fluence (time integrated flux); Class 1 bursts are softer, longer, and brighter than Class 2 bursts (with two second durations indicating a rough division). A third GRB subclass, overlapping the other two, has been identified using statistical clustering techniques; Class 3 bursts are intermediate between Class 1 and Class 2 bursts in brightness and duration, but are softer than Class 1 bursts. We are developing a tool to aid scientists in the study of GRB properties. In the process of developing this tool, we are building a large gamma-ray burst classification database. We are also scientifically analyzing some GRB data as we develop the tool. Tool development thus proceeds in tandem with the dataset for which it is being designed. The tool invokes a modified KDD (Knowledge Discovery in Databases) process, which is described as follows.

zBEAMS: a unified solution for supernova cosmology with redshift uncertainties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, Ethan; Lochner, Michelle; Bassett, Bruce A.

Supernova cosmology without spectra will be an important component of future surveys such as LSST. This lack of supernova spectra results in uncertainty in the redshifts which, if ignored, leads to significantly biased estimates of cosmological parameters. Here we present a hierarchical Bayesian formalism— zBEAMS—that addresses this problem by marginalising over the unknown or uncertain supernova redshifts to produce unbiased cosmological estimates that are competitive with supernova data with spectroscopically confirmed redshifts. zBEAMS provides a unified treatment of both photometric redshifts and host galaxy misidentification (occurring due to chance galaxy alignments or faint hosts), effectively correcting the inevitable contamination inmore » the Hubble diagram. Like its predecessor BEAMS, our formalism also takes care of non-Ia supernova contamination by marginalising over the unknown supernova type. We illustrate this technique with simulations of supernovae with photometric redshifts and host galaxy misidentification. A novel feature of the photometric redshift case is the important role played by the redshift distribution of the supernovae.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahlgren, Björn; Larsson, Josefin; Nymark, Tanja

The origin of the prompt emission in gamma-ray bursts (GRBs) is still an unsolved problem and several different mechanisms have been suggested. We fit Fermi GRB data with a photospheric emission model which includes dissipation of the jet kinetic energy below the photosphere. The resulting spectra are dominated by Comptonization and contain no significant contribution from synchrotron radiation. In order to fit to the data, we span a physically motivated part of the model's parameter space and create DREAM (Dissipation with Radiative Emission as A table Model), a table model for XSPEC. Here, we show that this model can describemore » different kinds of GRB spectra, including GRB 090618, representing a typical Band function spectrum, and GRB 100724B, illustrating a double peaked spectrum, previously fitted with a Band+blackbody model, suggesting they originate from a similar scenario. We also suggest that the main difference between these two types of bursts is the optical depth at the dissipation site.« less

Detection prospects for GeV neutrinos from collisionally heated gamma-ray bursts with IceCube/DeepCore.

PubMed

Bartos, I; Beloborodov, A M; Hurley, K; Márka, S

2013-06-14

Jet reheating via nuclear collisions has recently been proposed as the main mechanism for gamma-ray burst (GRB) emission. In addition to producing the observed gamma rays, collisional heating must generate 10-100 GeV neutrinos, implying a close relation between the neutrino and gamma-ray luminosities. We exploit this theoretical relation to make predictions for possible GRB detections by IceCube + DeepCore. To estimate the expected neutrino signal, we use the largest sample of bursts observed by the Burst and Transient Source Experiment in 1991-2000. GRB neutrinos could have been detected if IceCube + DeepCore operated at that time. Detection of 10-100 GeV neutrinos would have significant implications, shedding light on the composition of GRB jets and their Lorentz factors. This could be an important target in designing future upgrades of the IceCube + DeepCore observatory.

AN EVOLVING STELLAR INITIAL MASS FUNCTION AND THE GAMMA-RAY BURST REDSHIFT DISTRIBUTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, F. Y.; Dai, Z. G.

2011-02-01

Recent studies suggest that Swift gamma-ray bursts (GRBs) may not trace an ordinary star formation history (SFH). Here, we show that the GRB rate turns out to be consistent with the SFH with an evolving stellar initial mass function (IMF). We first show that the latest Swift sample of GRBs reveals an increasing evolution in the GRB rate relative to the ordinary star formation rate at high redshifts. We then assume only massive stars with masses greater than the critical value to produce GRBs and use an evolving stellar IMF suggested by Dave to fit the latest GRB redshift distribution.more » This evolving IMF would increase the relative number of massive stars, which could lead to more GRB explosions at high redshifts. We find that the evolving IMF can well reproduce the observed redshift distribution of Swift GRBs.« less

General Features of GRB 030329 in the EMBH Model

NASA Astrophysics Data System (ADS)

Bernardini, Maria Grazia; Bianco, Carlo Luciano; Ruffini, Remo; Xue, She-Sheng; Chardonnet, Pascal; Fraschetti, Federico

2006-02-01

GRB 030329 is considered within the EMBH model. We determine the three free parameters and deduce its luminosity in given energy bands comparing it with the observations. The observed substructures are compared with the predictions of the model: by applying the result that substructures observed in the extended afterglow peak emission (E-APE) do indeed originate in the collision of the accelerated baryonic matter (ABM) pulse with the inhomogeneities in the interstellar medium around the black-hole, masks of density inhomogeneities are considered in order to reproduce the observed temporal substructures. The induced supernova concept is applied to this system and the general consequences that we are witnessing are the formation of a cosmological thriptych of a black hole originating the GRB 030329, the supernova SN2003dh and a young neutron star. Analogies to the system GRB 980425-SN1998bw are outlined.

Search for High-Energy Muon Neutrinos from the "Naked-Eye" GRB 080319B with the IceCube Neutrino Telescope

NASA Astrophysics Data System (ADS)

Abbasi, R.; Abdou, Y.; Abu-Zayyad, T.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Bay, R.; Bazo Alba, J. L.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker, J. K.; Becker, K.-H.; Benabderrahmane, M. L.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bissok, M.; Blaufuss, E.; Boersma, D. J.; Bohm, C.; Bolmont, J.; Botner, O.; Bradley, L.; Braun, J.; Breder, D.; Castermans, T.; Chirkin, D.; Christy, B.; Clem, J.; Cohen, S.; Cowen, D. F.; D'Agostino, M. V.; Danninger, M.; Day, C. T.; De Clercq, C.; Demirörs, L.; Depaepe, O.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; DeYoung, T.; Diaz-Velez, J. C.; Dreyer, J.; Dumm, J. P.; Duvoort, M. R.; Edwards, W. R.; Ehrlich, R.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Feusels, T.; Filimonov, K.; Finley, C.; Foerster, M. M.; Fox, B. D.; Franckowiak, A.; Franke, R.; Gaisser, T. K.; Gallagher, J.; Ganugapati, R.; Gerhardt, L.; Gladstone, L.; Goldschmidt, A.; Goodman, J. A.; Gozzini, R.; Grant, D.; Griesel, T.; Groß, A.; Grullon, S.; Gunasingha, R. M.; Gurtner, M.; Ha, C.; Hallgren, A.; Halzen, F.; Han, K.; Hanson, K.; Hasegawa, Y.; Heise, J.; Helbing, K.; Herquet, P.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Hoshina, K.; Hubert, D.; Huelsnitz, W.; Hülß, J.-P.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Imlay, R. L.; Inaba, M.; Ishihara, A.; Jacobsen, J.; Japaridze, G. S.; Johansson, H.; Joseph, J. M.; Kampert, K.-H.; Kappes, A.; Karg, T.; Karle, A.; Kelley, J. L.; Kenny, P.; Kiryluk, J.; Kislat, F.; Klein, S. R.; Knops, S.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Kowalski, M.; Kowarik, T.; Krasberg, M.; Kuehn, K.; Kuwabara, T.; Labare, M.; Lafebre, S.; Laihem, K.; Landsman, H.; Lauer, R.; Lennarz, D.; Lucke, A.; Lundberg, J.; Lünemann, J.; Madsen, J.; Majumdar, P.; Maruyama, R.; Mase, K.; Matis, H. S.; McParland, C. P.; Meagher, K.; Merck, M.; Mészáros, P.; Middell, E.; Milke, N.; Miyamoto, H.; Mohr, A.; Montaruli, T.; Morse, R.; Movit, S. M.; Münich, K.; Nahnhauer, R.; Nam, J. W.; Nießen, P.; Nygren, D. R.; Odrowski, S.; Olivas, A.; Olivo, M.; Ono, M.; Panknin, S.; Patton, S.; Pérez de los Heros, C.; Petrovic, J.; Piegsa, A.; Pieloth, D.; Pohl, A. C.; Porrata, R.; Potthoff, N.; Price, P. B.; Prikockis, M.; Przybylski, G. T.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Rizzo, A.; Rodrigues, J. P.; Roth, P.; Rothmaier, F.; Rott, C.; Roucelle, C.; Rutledge, D.; Ryckbosch, D.; Sander, H.-G.; Sarkar, S.; Schlenstedt, S.; Schmidt, T.; Schneider, D.; Schukraft, A.; Schulz, O.; Schunck, M.; Seckel, D.; Semburg, B.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Silvestri, A.; Slipak, A.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stephens, G.; Stezelberger, T.; Stokstad, R. G.; Stoufer, M. C.; Stoyanov, S.; Strahler, E. A.; Straszheim, T.; Sulanke, K.-H.; Sullivan, G. W.; Swillens, Q.; Taboada, I.; Tamburro, A.; Tarasova, O.; Tepe, A.; Ter-Antonyan, S.; Terranova, C.; Tilav, S.; Toale, P. A.; Tosi, D.; Turčan, D.; van Eijndhoven, N.; Vandenbroucke, J.; Van Overloop, A.; Voigt, B.; Walck, C.; Waldenmaier, T.; Walter, M.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebusch, C. H.; Wiedemann, A.; Wikström, G.; Williams, D. R.; Wischnewski, R.; Wissing, H.; Woschnagg, K.; Xu, X. W.; Yodh, G.; Yoshida, S.; IceCube Collaboration

2009-08-01

We report on a search with the IceCube detector for high-energy muon neutrinos from GRB 080319B, one of the brightest gamma-ray bursts (GRBs) ever observed. The fireball model predicts that a mean of 0.1 events should be detected by IceCube for a bulk Lorentz boost of the jet of 300. In both the direct on-time window of 66 s and an extended window of about 300 s around the GRB, no excess was found above background. The 90% CL upper limit on the number of track-like events from the GRB is 2.7, corresponding to a muon neutrino fluence limit of 9.5 × 10-3 erg cm-2 in the energy range between 120 TeV and 2.2 PeV, which contains 90% of the expected events.

NuSTAR observations of GRB 130427A establish a single component synchrotron afterglow origin for the late optical to multi-GEV emission

DOE PAGES

Kouveliotou, Chryssa; Granot, J.; Racusin, J. L.; ...

2013-11-21

Here, GRB 130427A occurred in a relatively nearby galaxy; its prompt emission had the largest GRB fluence ever recorded. The afterglow of GRB 130427A was bright enough for the Nuclear Spectroscopic Telescope ARray ( NuSTAR) to observe it in the 3-79 keV energy range long after its prompt emission (~1.5 and 5 days). This range, where afterglow observations were previously not possible, bridges an important spectral gap. Combined with Swift, Fermi, and ground-based optical data, NuSTAR observations unambiguously establish a single afterglow spectral component from optical to multi-GeV energies a day after the event, which is almost certainly synchrotron radiation.more » Such an origin of the late-time Fermi/Large Area Telescope >10 GeV photons requires revisions in our understanding of collisionless relativistic shock physics.« less

BATSE analysis techniques for probing the GRB spatial and luminosity distributions

NASA Technical Reports Server (NTRS)

Hakkila, Jon; Meegan, Charles A.

1992-01-01

The Burst And Transient Source Experiment (BATSE) has measured homogeneity and isotropy parameters from an increasingly large sample of observed gamma-ray bursts (GRBs), while also maintaining a summary of the way in which the sky has been sampled. Measurement of both of these are necessary for any study of the BATSE data statistically, as they take into account the most serious observational selection effects known in the study of GRBs: beam-smearing and inhomogeneous, anisotropic sky sampling. Knowledge of these effects is important to analysis of GRB angular and intensity distributions. In addition to determining that the bursts are local, it is hoped that analysis of such distributions will allow boundaries to be placed on the true GRB spatial distribution and luminosity function. The technique for studying GRB spatial and luminosity distributions is direct. Results of BATSE analyses are compared to Monte Carlo models parameterized by a variety of spatial and luminosity characteristics.

Fainting

MedlinePlus

... pressure. Why Do People Faint? Fainting is pretty common in teens. The good news is that most of the time it's not a sign of something serious. When someone faints, it's usually because ... ventilated setting are common causes of fainting in teens. People can also ...

GRB/GW Association: Long-Short GRB Candidates, Time Lag, Measuring Gravitational Wave Velocity, and Testing Einstein’s Equivalence Principle

NASA Astrophysics Data System (ADS)

Li, Xiang; Hu, Yi-Ming; Fan, Yi-Zhong; Wei, Da-Ming

2016-08-01

Short-duration gamma-ray bursts (SGRBs) are widely believed to be powered by the mergers of compact binaries, such as binary neutron stars or possibly neutron star-black hole binaries. Though the prospect of detecting SGRBs with gravitational wave (GW) signals by the advanced Laser Interferometer Gravitational-Wave Observatory (LIGO)/VIRGO network is promising, no known SGRB has been found within the expected advanced LIGO/VIRGO sensitivity range for binary neutron star systems. We find, however, that the two long-short GRBs (GRB 060505 and GRB 060614) may be within the horizon of advanced GW detectors. In the upcoming era of GW astronomy, the merger origin of some long-short GRBs, as favored by the macronova signature displayed in GRB 060614, can be unambiguously tested. The model-dependent time lags between the merger and the onset of the prompt emission of the GRB are estimated. The comparison of such time lags between model predictions and the real data expected in the era of the GW astronomy would be helpful in revealing the physical processes taking place at the central engine (including the launch of the relativistic outflow, the emergence of the outflow from the dense material ejected during the merger, and the radiation of gamma rays). We also show that the speed of GWs, with or without a simultaneous test of Einstein’s equivalence principle, can be directly measured to an accuracy of ˜ 3× {10}-8 {cm} {{{s}}}-1 or even better in the advanced LIGO/VIRGO era.

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin.

PubMed

Pruett, W; Yuan, Y; Rose, E; Batzer, A G; Harada, N; Skolnik, E Y

1995-03-01

Insulin receptor substrate 1 (IRS-1) mediates the activation of a variety of signaling pathways by the insulin and insulin-like growth factor 1 receptors by serving as a docking protein for signaling molecules with SH2 domains. We and others have shown that in response to insulin stimulation IRS-1 binds GRB2/Sos and have proposed that this interaction is important in mediating Ras activation by the insulin receptor. Recently, it has been shown that the interleukin (IL)-4 receptor also phosphorylates IRS-1 and an IRS-1-related molecule, 4PS. Unlike insulin, however, IL-4 fails to activate Ras, extracellular signal-regulated kinases (ERKs), or mitogen-activated protein kinases. We have reconstituted the IL-4 receptor into an insulin-responsive L6 myoblast cell line and have shown that IRS-1 is tyrosine phosphorylated to similar degrees in response to insulin and IL-4 stimulation in this cell line. In agreement with previous findings, IL-4 failed to activate the ERKs in this cell line or to stimulate DNA synthesis, whereas the same responses were activated by insulin. Surprisingly, IL-4's failure to activate ERKs was not due to a failure to stimulate the association of tyrosine-phosphorylated IRS-1 with GRB2/Sos; the amounts of GRB2/Sos associated with IRS-1 were similar in insulin- and IL-4-stimulated cells. Moreover, the amounts of phosphatidylinositol 3-kinase activity associated with IRS-1 were similar in insulin- and IL-4-stimulated cells. In contrast to insulin, however, IL-4 failed to induce tyrosine phosphorylation of Shc or association of Shc with GRB2. Thus, ERK activation correlates with Shc tyrosine phosphorylation and formation of an Shc/GRB2 complex. Thus, ERK activation correlates with Shc tyrosine phosphorylation and formation of an Shc/GRB2 complex. Previous studies have indicated that activation of ERks in this cell line is dependent upon Ras since a dominant-negative Ras (Asn-17) blocks ERK activation by insulin. Our findings, taken in the context of previous work, suggest that binding of GRB2/Sos to Shc may be the predominant mechanism whereby insulin as well as cytokine receptors activate Ras.

The red-sequence of 72 WINGS local galaxy clusters

NASA Astrophysics Data System (ADS)

Valentinuzzi, T.; Poggianti, B. M.; Fasano, G.; D'Onofrio, M.; Moretti, A.; Ramella, M.; Biviano, A.; Fritz, J.; Varela, J.; Bettoni, D.; Vulcani, B.; Moles, M.; Couch, W. J.; Dressler, A.; Kjærgaard, P.; Omizzolo, A.; Cava, A.

2011-12-01

We study the color - magnitude red sequence and blue fraction of 72 X-ray selected galaxy clusters at z = 0.04-0.07 from the WINGS survey, searching for correlations between the characteristics of the red sequence (RS) and the environment. We consider the slope and scatter of the red sequence, the number ratio of red luminous-to-faint galaxies, the blue fraction, and the fractions of ellipticals, S0s, and spirals that compose the RS. None of these quantities correlate with the cluster velocity dispersion, X-ray luminosity, number of cluster substructures, BCG prevalence over next brightest galaxies, and the spatial concentration of ellipticals. The properties of the RS, instead, depend strongly on local galaxy density. Higher density regions have a smaller RS scatter, a higher luminous-to-faint ratio, a lower blue fraction, and a lower spiral fraction on the RS. Our results clearly illustrate the prominent effect of the local density in setting the epoch when galaxies become passive and join the red sequence, as opposed to the mass of the galaxy host structure.

Using the Gurobi Solvers on the Peregrine System | High-Performance

Science.gov Websites

Peregrine System Gurobi Optimizer is a suite of solvers for mathematical programming. It is licensed for ('GRB_MATLAB_PATH') >> path(path,grb) Gurobi and GAMS GAMS is a high-level modeling system for mathematical

the Large Aperture GRB Observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertou, Xavier

2009-04-30

The Large Aperture GRB Observatory (LAGO) aims at the detection of high energy photons from Gamma Ray Bursts (GRB) using the single particle technique (SPT) in ground based water Cherenkov detectors (WCD). To reach a reasonable sensitivity, high altitude mountain sites have been selected in Mexico (Sierra Negra, 4550 m a.s.l.), Bolivia (Chacaltaya, 5300 m a.s.l.) and Venezuela (Merida, 4765 m a.s.l.). We report on the project progresses and the first operation at high altitude, search for bursts in 6 months of preliminary data, as well as search for signal at ground level when satellites report a burst.

Early optical polarization of a gamma-ray burst afterglow.

PubMed

Mundell, Carole G; Steele, Iain A; Smith, Robert J; Kobayashi, Shiho; Melandri, Andrea; Guidorzi, Cristiano; Gomboc, Andreja; Mottram, Chris J; Clarke, David; Monfardini, Alessandro; Carter, David; Bersier, David

2007-03-30

We report the optical polarization of a gamma-ray burst (GRB) afterglow, obtained 203 seconds after the initial burst of gamma-rays from GRB 060418, using a ring polarimeter on the robotic Liverpool Telescope. Our robust (2sigma) upper limit on the percentage of polarization, less than 8%, coincides with the fireball deceleration time at the onset of the afterglow. The combination of the rate of decay of the optical brightness and the low polarization at this critical time constrains standard models of GRB ejecta, ruling out the presence of a large-scale ordered magnetic field in the emitting region.

The Supercritical Pile Model for GRBs

NASA Technical Reports Server (NTRS)

Kazanas, D.

2005-01-01

We present the spectral and temporal radiative signatures expected within the "Supercritical Pile" model of Gamma Ray Bursts (GRB). This model is motivated by the need for a process that provides the dissipation necessary in GRB and presents a well defined scheme for converting the energy stored in the relativistic protons of the Relativistic Blast Waves (RBW) associated with GRB into radiation; at the same time it leads to spectra which exhibit a peak in the burst nuF(sub nu) distribution at an energy E(sub p) approx. equal to 1 MeV in the observer s frame, in agreement with observation and largely independent of the Lorentz factor r of the associated relativistic outflow. Futhermore, this scheme does not require (but does not preclude) acceleration of particles at the shock other than that provided by the isotropization of the flow bulk kinetic energy on the RBW frame. In the present paper we model in detail the evolution of protons, electrons and photons from a RBW to produce detailed spectra of the prompt GRB phase as a function of time from across a very broad range spanning roughly 4 log10Gamma decades in frequency. The model spectra are in general agreement with observations and provide a means for the delineating of the model parameters through direct comparison with trends observed in GRB properties.

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.

PubMed

Rozakis-Adcock, M; Fernley, R; Wade, J; Pawson, T; Bowtell, D

1993-05-06

Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggesting that these tyrosine kinases may activate a guanine-nucleotide releasing protein (GNRP). In Caenorhabditis elegans and Drosophila, genetic studies have shown that Ras activation by tyrosine kinases requires the protein Sem-5/drk, which contains a single Src-homology (SH) 2 domain and two flanking SH3 domains. Sem-5 is homologous to the mammalian protein Grb2, which binds the autophosphorylated EGF receptor and other phosphotyrosine-containing proteins such as Shc through its SH2 domain. Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos. Sos is required for Ras signalling and contains a central domain related to known Ras-GNRPs. EGF stimulation induces binding of the Grb2-mSos1 complex to the autophosphorylated EGF receptor, and mSos1 phosphorylation. Grb2 therefore appears to link tyrosine kinases to a Ras-GNRP in mammalian cells.

The Supercritical Pile Model for GRBs

NASA Technical Reports Server (NTRS)

Kazanas, Demos

2005-01-01

We present the spectral and tempora1 radiative signatures expected within the "Supercritical Pile" model of Gamma Ray Bursts (GRB). This model is motivated by the need for a process that provides the dissipation necessary in GRB and presents a well defined theme for converting the energy stored in the relativistic protons of the Relativistic Blast Waves (RBW) associated with GRB into radiation; at the same it leads to spectra which exhibit a peak in the burst vFv, distribution at an energy Ep l. MeV in the observer's frame, in agreement with observation and largely independent of the Lorentz factor P of the associated relativistic outflow. Furthermore, this scheme does not require (but does not preclude) acceleration of particles at the shock other than that provided by the isotropization of the flow kinetic energy on the RBW frame. In the present paper we model in detail the evolution of protons, electrons and photons from a RBW within the framework of this model to produce detailed spectra of the prompt GRB phase as a function of time from across a very broad range spanning roughly 4log10P decades in frequency. The model spectra are in general agreement with observations and provide a means for the delineating of the model parameters through direct comparison with trends observed in GRB properties.

The Supercritical Pile Model for GRBs

NASA Technical Reports Server (NTRS)

Kazanas, Demos

2006-01-01

We present the spectral and temporal radiative signatures expected within the Supercritical Pile model of Gamma Ray Bursts (GRB). This model is motivated by the need for a process that provides the dissipation necessary in GRB and presents a well defined scheme for converting the energy stored in the relativistic protons of the Relativistic Blast Waves (RBW) associated with GRB into radiation; at the same time it leads to spectra which exhibit a peak in the burst nuF(sub nu) distribution at an energy E(sub p) approximately equal to 1 MeV in the observer s frame, in agreement with observation and largely independent of the Lorentz factor GAMMA of the associated relativistic outflow. Furthermore, this scheme does not require (but does not preclude) acceleration of particles at the shock other than that provided by the isotropization of the flow bulk kinetic energy on the RBW frame. In the present paper we model in detail the evolution of protons, electrons and photons from a RBW to produce detailed spectra of the prompt GRB phase as a function of time from across a very broad range spanning roughly 4 log10 GAMMA decades in frequency. The model spectra are in general agreement with observations and provide a means for the delineating of the model parameters through direct comparison with trends observed in GRB properties.

GRB 060505: A Possible Short-Duration Gamma-Ray Burst in a Star Forming Region at Redshift of 0.09

NASA Technical Reports Server (NTRS)

Ofek, E. O.; Cenko, S. B.; Gal-Yam, A.; Fox, D. B.; Nakar, E.; Rau, A.; Frail, D. A.; Kullkarni, S. R.; Price, P. A.; Schmidt, B. P.;

Photospheric Emission in the Joint GBM and Konus Prompt Spectra of GRB 120323A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guiriec, S.; Kouveliotou, C.; Gehrels, N.

GRB 120323A is a very intense short gamma -ray burst (GRB) detected simultaneously during its prompt γ -ray emission phase with the Gamma-ray Burst Monitor (GBM) on board the Fermi Gamma-ray Space Telescope and the Konus experiment on board the Wind satellite. GBM and Konus operate in the keV–MeV regime; however, the GBM range is broader toward both the low and the high parts of the γ -ray spectrum. Analyses of such bright events provide a unique opportunity to check the consistency of the data analysis as well as cross-calibrate the two instruments. We performed time-integrated and coarse time-resolved spectralmore » analysis of GRB 120323A prompt emission. We conclude that the analyses of GBM and Konus data are only consistent when using a double-hump spectral shape for both data sets; in contrast, the single hump of the empirical Band function, traditionally used to fit GRB prompt emission spectra, leads to significant discrepancies between GBM and Konus analysis results. Our two-hump model is a combination of a thermal-like and a non-thermal component. We interpret the first component as a natural manifestation of the jet photospheric emission.« less

Radio afterglow rebrightening: evidence for multiple active phases in gamma-ray burst central engines

NASA Astrophysics Data System (ADS)

Li, Long-Biao; Zhang, Zhi-Bin; Rice, Jared

2015-09-01

The rebrightening phenomenon is an interesting feature in some X-ray, optical, and radio afterglows of gamma-ray bursts (GRBs). Here, we propose a possible energy-supply assumption to explain the rebrightenings of radio afterglows, in which the central engine with multiple active phases can supply at least two GRB pulses in a typical GRB duration time. Considering the case of double pulses supplied by the central engine, the double pulses have separate physical parameters, except for the number density of the surrounding interstellar medium (ISM). Their independent radio afterglows are integrated by the ground detectors to form the rebrightening phenomenon. In this Letter, we firstly simulate diverse rebrightening light curves under consideration of different and independent physical parameters. Using this assumption, we also give our best fit to the radio afterglow of GRB 970508 at three frequencies of 1.43, 4.86, and 8.46 GHz. We suggest that the central engine may be active continuously at a timescale longer than that of a typical GRB duration time as many authors have suggested (e.g., Zhang et al., Astrophys. J. 787:66, 2014; Gao and Mészáros, Astrophys. J. 802:90, 2015), and that it may supply enough energy to cause the long-lasting rebrightenings observed in some GRB afterglows.

[C ii] 158-μm emission from the host galaxies of damped Lyman-alpha systems.

PubMed

Neeleman, Marcel; Kanekar, Nissim; Prochaska, J Xavier; Rafelski, Marc; Carilli, Chris L; Wolfe, Arthur M

2017-03-24

Gas surrounding high-redshift galaxies has been studied through observations of absorption line systems toward background quasars for decades. However, it has proven difficult to identify and characterize the galaxies associated with these absorbers due to the intrinsic faintness of the galaxies compared with the quasars at optical wavelengths. Using the Atacama Large Millimeter/Submillimeter Array, we report on detections of [C ii] 158-μm line and dust-continuum emission from two galaxies associated with two such absorbers at a redshift of z ~ 4. Our results indicate that the hosts of these high-metallicity absorbers have physical properties similar to massive star-forming galaxies and are embedded in enriched neutral hydrogen gas reservoirs that extend well beyond the star-forming interstellar medium of these galaxies. Copyright © 2017, American Association for the Advancement of Science.

The Konus-Wind Catalog of Gamma-Ray Bursts with Known Redshifts. I. Bursts Detected in the Triggered Mode

NASA Astrophysics Data System (ADS)

Tsvetkova, A.; Frederiks, D.; Golenetskii, S.; Lysenko, A.; Oleynik, P.; Pal'shin, V.; Svinkin, D.; Ulanov, M.; Cline, T.; Hurley, K.; Aptekar, R.

2017-12-01

In this catalog, we present the results of a systematic study of gamma-ray bursts (GRBs) with reliable redshift estimates detected in the triggered mode of the Konus-Wind (KW) experiment during the period from 1997 February to 2016 June. The sample consists of 150 GRBs (including 12 short/hard bursts) and represents the largest set of cosmological GRBs studied to date over a broad energy band. From the temporal and spectral analyses of the sample, we provide the burst durations, the spectral lags, the results of spectral fits with two model functions, the total energy fluences, and the peak energy fluxes. Based on the GRB redshifts, which span the range 0.1≤slant z≤slant 5, we estimate the rest-frame, isotropic-equivalent energy, and peak luminosity. For 32 GRBs with reasonably constrained jet breaks, we provide the collimation-corrected values of the energetics. We consider the behavior of the rest-frame GRB parameters in the hardness-duration and hardness-intensity planes, and confirm the “Amati” and “Yonetoku” relations for Type II GRBs. The correction for the jet collimation does not improve these correlations for the KW sample. We discuss the influence of instrumental selection effects on the GRB parameter distributions and estimate the KW GRB detection horizon, which extends to z˜ 16.6, stressing the importance of GRBs as probes of the early universe. Accounting for the instrumental bias, we estimate the KW GRB luminosity evolution, luminosity and isotropic-energy functions, and the evolution of the GRB formation rate, which are in general agreement with those obtained in previous studies.

Thermal Emissions Spanning the Prompt and the Afterglow Phases of the Ultra-long GRB 130925A

NASA Astrophysics Data System (ADS)

Basak, Rupal; Rao, A. R.

2015-07-01

GRB 130925A is an ultra-long gamma-ray burst (GRB), and it shows clear evidence for thermal emission in the soft X-ray data of the Swift/X-ray Telescope (XRT; ∼0.5 keV), lasting until the X-ray afterglow phase. Due to the long duration of the GRB, the burst could be studied in hard X-rays with high-resolution focusing detectors (NuSTAR). The blackbody temperature, as measured by the Swift/XRT, shows a decreasing trend until the late phase (Piro et al.) whereas the high-energy data reveal a significant blackbody component during the late epochs at an order of magnitude higher temperature (∼5 keV) compared to contemporaneous low energy data (Bellm et al.). We resolve this apparent contradiction by demonstrating that a model with two black bodies and a power law (2BBPL) is consistent with the data right from the late prompt emission to the afterglow phase. Both blackbodies show a similar cooling behavior up to late times. We invoke a structured jet, having a fast spine and a slower sheath layer, to identify the location of these blackbodies. Independent of the physical interpretation, we propose that the 2BBPL model is a generic feature of the prompt emission of all long GRBs, and the thermal emission found in the afterglow phase of different GRBs reflects the lingering thermal component of the prompt emission with different timescales. We strengthen this proposal by pointing out a close similarity between the spectral evolutions of this GRB and GRB 090618, a source with significant wide band data during the early afterglow phase.

SWIFT OBSERVATIONS OF GAMMA-RAY BURST PULSE SHAPES: GRB PULSE SPECTRAL EVOLUTION CLARIFIED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hakkila, Jon; Lien, Amy; Sakamoto, Takanori

Isolated Swift gamma-ray burst (GRB) pulses, like their higher-energy BATSE counterparts, emit the bulk of their pulsed emission as a hard-to-soft component that can be fitted by the Norris et al. empirical pulse model. This signal is overlaid by a fainter, three-peaked signal that can be modeled by the residual fit of Hakkila and Preece: the two fits combine to reproduce GRB pulses with distinctive three-peaked shapes. The precursor peak appears on or before the pulse rise and is often the hardest component, the central peak is the brightest, and the decay peak converts exponentially decaying emission into a long,more » soft, power-law tail. Accounting for systematic instrumental differences, the general characteristics of the fitted pulses are remarkably similar. Isolated GRB pulses are dominated by hard-to-soft evolution; this is more pronounced for asymmetric pulses than for symmetric ones. Isolated GRB pulses can also exhibit intensity tracking behaviors that, when observed, are tied to the timing of the three peaks: pulses with the largest maximum hardnesses are hardest during the precursor, those with smaller maximum hardnesses are hardest during the central peak, and all pulses can re-harden during the central peak and/or during the decay peak. Since these behaviors are essentially seen in all isolated pulses, the distinction between “hard-to-soft and “intensity-tracking” pulses really no longer applies. Additionally, the triple-peaked nature of isolated GRB pulses seems to indicate that energy is injected on three separate occasions during the pulse duration: theoretical pulse models need to account for this.« less

The Supercritical Pile GRB Model: The Prompt to Afterglow Evolution

NASA Technical Reports Server (NTRS)

Kazanas, Demosthenes

2008-01-01

The 'Supercritical Pile' is a very economical gamma ray burst (GRB) model that provides for the efficient conversion of the energy stored in the protons of a Relativistic Blast Wave (RBW) into radiation and at the same time produces - in the prompt GRB phase, even in the absence of any particle acceleration - a spectral peak at an energy sim 1 MeV. We extend this model to include also the evolution of the RBW Lorentz factor Gamma and thus follow the spectral and temporal features of this model into the early GRB afterglow stage. One of the novel features of the present treatment is the inclusion of the feedback of the GRB produced radiation on the evolution of Gamma with radius. This feedback and the presence of kinematic and dynamic thresholds in the model can be the sources of rich time evolution which we have begun to explore. In particular, one can this way obtain afterglow light curves with steep decays followed by the more conventional flatter afterglow slopes, while at the same time preserving the desirable features of the model, i.e. the well defined relativistic electron source and radiative processes that produce the proper peak in the nu F spectra. Furthermore, the existence of a kinematic threshold in this model provides for a operational distinction of the prompt and afterglow GRB stages; in fact, the afterglow stage sets in when the RBW Lorentz factor cannot anymore fulfill the kinematic condition for pair formation in the photon - proton pair production reactions that constitute the fundamental process for the dissipation of the blast wave kinetic energy. We present the results of a specific set of parameters of this model with emphasis on the multiwavelength prompt emission and transition to the early afterglow.

Effect of carbamate pesticides on perforin, granzymes A-B-3/K, and granulysin in human natural killer cells.

PubMed

Li, Qing; Kobayashi, Maiko; Kawada, Tomoyuki

2015-09-01

We previously found that ziram, a carbamate pesticide, significantly reduced perforin, granzyme A (GrA), granzyme B (GrB), granzyme 3/K (Gr3/K), and granulysin (GRN) levels in NK-92MI cells, a human natural killer (NK) cell line. To investigate whether other carbamate pesticides also show similar toxicity on human NK cells, we conducted further experiments with NK-92CI cells, a human NK cell line, using a more sensitive assay. We previously confirmed that NK-92CI cells express CD56, perforin, GrA, GrB, Gr3/K, and GRN and are highly cytotoxic to K562 cells in a chromium release assay, which are more sensitive to organophosphorus pesticides and ziram than the NK-92MI cell line. NK-92CI cells were treated with ziram, thiram, maneb, or carbaryl at various concentrations for 4-24 h at 37°C in vitro. Thereafter, intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN were determined by flow cytometry. It was found that all carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells in a dose-dependent manner. However, the strength of the effect differed among the pesticides, and the order was thiram > ziram > maneb > carbaryl. In addition, it was also found that the degree of the reductions differed among the five proteins, with perforin more sensitive to pesticides than GRN, GrA, GrB, and Gr3/K, and the order was perforin > GRN > Gr3/K ≒ GrA ≒ GrB. © The Author(s) 2015.

The Arcminute Microkelvin Imager catalogue of gamma-ray burst afterglows at 15.7 GHz

NASA Astrophysics Data System (ADS)

Anderson, G. E.; Staley, T. D.; van der Horst, A. J.; Fender, R. P.; Rowlinson, A.; Mooley, K. P.; Broderick, J. W.; Wijers, R. A. M. J.; Rumsey, C.; Titterington, D. J.

2018-01-01

We present the Arcminute Microkelvin Imager (AMI) Large Array catalogue of 139 gamma-ray bursts (GRBs). AMI observes at a central frequency of 15.7 GHz and is equipped with a fully automated rapid-response mode, which enables the telescope to respond to high-energy transients detected by Swift. On receiving a transient alert, AMI can be on-target within 2 min, scheduling later start times if the source is below the horizon. Further AMI observations are manually scheduled for several days following the trigger. The AMI GRB programme probes the early-time (<1 d) radio properties of GRBs, and has obtained some of the earliest radio detections (GRB 130427A at 0.36 and GRB 130907A at 0.51 d post-burst). As all Swift GRBs visible to AMI are observed, this catalogue provides the first representative sample of GRB radio properties, unbiased by multiwavelength selection criteria. We report the detection of six GRB radio afterglows that were not previously detected by other radio telescopes, increasing the rate of radio detections by 50 per cent over an 18-month period. The AMI catalogue implies a Swift GRB radio detection rate of ≳ 15 per cent, down to ∼0.2 mJy beam-1. However, scaling this by the fraction of GRBs AMI would have detected in the Chandra & Frail sample (all radio-observed GRBs between 1997 and 2011), it is possible ∼ 44-56 per cent of Swift GRBs are radio bright, down to ∼0.1-0.15 mJy beam-1. This increase from the Chandra & Frail rate (∼30 per cent) is likely due to the AMI rapid-response mode, which allows observations to begin while the reverse-shock is contributing to the radio afterglow.

HIGH-ENERGY EMISSION OF GRB 130427A: EVIDENCE FOR INVERSE COMPTON RADIATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, Yi-Zhong; Zhang, Fu-Wen; He, Hao-Ning

2013-10-20

A nearby superluminous burst GRB 130427A was simultaneously detected by six γ-ray space telescopes (Swift, the Fermi GLAST Burst Monitor (GBM)/Large Area Telescope, Konus-Wind, SPI-ACS/INTEGRAL, AGILE, and RHESSI) and by three RAPTOR full-sky persistent monitors. The isotropic γ-ray energy release is ∼10{sup 54} erg, rendering it the most powerful explosion among gamma-ray bursts (GRBs) with a redshift z ≤ 0.5. The emission above 100 MeV lasted about one day, and four photons are at energies greater than 40 GeV. We show that the count rate of 100 MeV-100 GeV emission may be mainly accounted for by the forward shock synchrotronmore » radiation and the inverse Compton radiation likely dominates at GeV-TeV energies. In particular, an inverse Compton radiation origin is favored for the ∼(95.3, 47.3, 41.4, 38.5, 32) GeV photons arriving at t ∼ (243, 256.3, 610.6, 3409.8, 34366.2) s after the trigger of Fermi-GBM. Interestingly, the external inverse Compton scattering of the prompt emission (the second episode, i.e., t ∼ 120-260 s) by the forward-shock-accelerated electrons is expected to produce a few γ-rays at energies above 10 GeV, while five were detected in the same time interval. A possible unified model for the prompt soft γ-ray, optical, and GeV emission of GRB 130427A, GRB 080319B, and GRB 090902B is outlined. Implications of the null detection of >1 TeV neutrinos from GRB 130427A by IceCube are discussed.« less

A Jet Break in the X-ray Light Curve of Short GRB 111020A: Implications for Energetics and Rates

NASA Technical Reports Server (NTRS)

Fong, W.; Berger, E.; Margutti, R.; Zauderer, B. A.; Troja, E.; Czekala, I.; Chornock, R.; Gehrels, N.; Sakamoto, T.; Fox, D. B.;

ePESSTO spectra and ATLAS photometry of SN2017iuk associated with GRB171205A

NASA Astrophysics Data System (ADS)

Prentice, S.; Mazzali, P.; Smartt, S. J.; Angus, C. R.; Firth, R. E.; Frohmaier, C.; Smith, M.; Barbarino, C.; Anderson, J.; Dennefeld, M.; Inserra, C.; Kankare, E.; Maguire, K.; Smartt, S. J.; Smith, K. W.; Sullivan, M.; Valenti, S.; Yaron, O.; Young, D.; Tonry, I. Manulis J.; Denneau, L.; Stalder, B.; Heinze, A.; Weiland, H.; Rest, A.; Fulton, M.; McBrien, O.

2017-12-01

ePESSTO, the extended Public ESO Spectroscopic Survey of Transient Objects, (see Smartt et al. 2015, A & A, 579, 40 http://www.pessto.org ), reports further spectral observations of SN 2017iuk, associated with GRB 171205A.

Comparative genomic analysis of the Haloferax volcanii DS2 and Halobacterium salinarium GRB contig maps reveals extensive rearrangement.

PubMed Central

St Jean, A; Charlebois, R L

1996-01-01

Anonymous probes from the genome of Halobacterium salinarium GRB and 12 gene probes were hybridized to the cosmid clones representing the chromosome and plasmids of Halobacterium salinarium GRB and Haloferax volcanii DS2. The order of and pairwise distances between 35 loci uniquely cross-hybridizing to both chromosomes were analyzed in a search for conservation. No conservation between the genomes could be detected at the 15-kbp resolution used in this study. We found distinct sets of low-copy-number repeated sequences in the chromosome and plasmids of Halobacterium salinarium GRB, indicating some degree of partitioning between these replicons. We propose alternative courses for the evolution of the haloarchaeal genome: (i) that the majority of genomic differences that exist between genera came about at the inception of this group or (ii) that the differences have accumulated over the lifetime of the lineage. The strengths and limitations of investigating these models through comparative genomic studies are discussed. PMID:8682791

Search for high-energy neutrinos from bright GRBs with ANTARES

NASA Astrophysics Data System (ADS)

Albert, A.; André, M.; Anghinolfi, M.; Anton, G.; Ardid, M.; Aubert, J.-J.; Avgitas, T.; Baret, B.; Barrios-Martí, J.; Basa, S.; Bertin, V.; Biagi, S.; Bormuth, R.; Bourret, S.; Bouwhuis, M. C.; Bruijn, R.; Brunner, J.; Busto, J.; Capone, A.; Caramete, L.; Carr, J.; Celli, S.; Chiarusi, T.; Circella, M.; Coelho, J. A. B.; Coleiro, A.; Coniglione, R.; Costantini, H.; Coyle, P.; Creusot, A.; Deschamps, A.; De Bonis, G.; Distefano, C.; di Palma, I.; Donzaud, C.; Dornic, D.; Drouhin, D.; Eberl, T.; El Bojaddaini, I.; Elsässer, D.; Enzenhöfer, A.; Felis, I.; Fusco, L. A.; Galatà, S.; Gay, P.; Geißelsöder, S.; Geyer, K.; Giordano, V.; Gleixner, A.; Glotin, H.; Gregoire, T.; Gracia-Ruiz, R.; Graf, K.; Hallmann, S.; van Haren, H.; Heijboer, A. J.; Hello, Y.; Hernández-Rey, J. J.; Hößl, J.; Hofestädt, J.; Hugon, C.; Illuminati, G.; James, C. W.; de Jong, M.; Jongen, M.; Kadler, M.; Kalekin, O.; Katz, U.; Kießling, D.; Kouchner, A.; Kreter, M.; Kreykenbohm, I.; Kulikovskiy, V.; Lachaud, C.; Lahmann, R.; Lefèvre, D.; Leonora, E.; Lotze, M.; Loucatos, S.; Marcelin, M.; Margiotta, A.; Marinelli, A.; Martínez-Mora, J. A.; Mathieu, A.; Mele, R.; Melis, K.; Michael, T.; Migliozzi, P.; Moussa, A.; Mueller, C.; Nezri, E.; Păvălaş, G. E.; Pellegrino, C.; Perrina, C.; Piattelli, P.; Popa, V.; Pradier, T.; Quinn, L.; Racca, C.; Riccobene, G.; Roensch, K.; Sánchez-Losa, A.; Saldaña, M.; Salvadori, I.; Samtleben, D. F. E.; Sanguineti, M.; Sapienza, P.; Schnabel, J.; Schüssler, F.; Seitz, T.; Sieger, C.; Spurio, M.; Stolarczyk, Th.; Taiuti, M.; Tayalati, Y.; Trovato, A.; Tselengidou, M.; Turpin, D.; Tönnis, C.; Vallage, B.; Vallée, C.; Van Elewyck, V.; Vivolo, D.; Vizzocca, A.; Wagner, S.; Wilms, J.; Zornoza, J. D.; Zúñiga, J.

2017-07-01

Gamma-ray bursts are thought to be sites of hadronic acceleration, thus neutrinos are expected from the decay of charged particles, produced in pγ interactions. The methods and results of a search for muon neutrinos in the data of the ANTARES neutrino telescope from four bright GRBs (GRB 080916C, GRB 110918A, GRB 130427A and GRB 130505A) observed between 2008 and 2013 are presented. Two scenarios of the fireball model have been investigated: the internal shock scenario, leading to the production of neutrinos with energies mainly above 100 TeV, and the photospheric scenario, characterized by a low-energy component in neutrino spectra due to the assumption of neutrino production closer to the central engine. Since no neutrino events have been detected in temporal and spatial coincidence with these bursts, upper limits at 90 per cent confidence level on the expected neutrino fluxes are derived. The non-detection allows for directly constraining the bulk Lorentz factor of the jet Γ and the baryon loading fp.

Instrumentation of LOTIS: Livermore Optical Transient Imaging System; a fully automated wide field of view telescope system searching for simultaneous optical counterparts of gamma ray bursts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, H.S.; Ables, E.; Barthelmy, S.D.

LOTIS is a rapidly slewing wide-field-of-view telescope which was designed and constructed to search for simultaneous gamma-ray burst (GRB) optical counterparts. This experiment requires a rapidly slewing ({lt} 10 sec), wide-field-of-view ({gt} 15{degrees}), automatic and dedicated telescope. LOTIS utilizes commercial tele-photo lenses and custom 2048 x 2048 CCD cameras to view a 17.6 x 17.6{degrees} field of view. It can point to any part of the sky within 5 sec and is fully automated. It is connected via Internet socket to the GRB coordinate distribution network which analyzes telemetry from the satellite and delivers GRB coordinate information in real-time. LOTISmore » started routine operation in Oct. 1996. In the idle time between GRB triggers, LOTIS systematically surveys the entire available sky every night for new optical transients. This paper will describe the system design and performance.« less

The Swift X-Ray Te1escope: Status and Performance

NASA Technical Reports Server (NTRS)

Burrows, David N.; Kennea, J.A.; Abbey, A.F.; Beardmore, A.; Campana, S.; Capalbi, M.; Chincarini, G.; Cusumano, G.; Evans, P.A.; Hill, J.E.;

The Needle in the 100 deg2 Haystack: Uncovering Afterglows of Fermi GRBs with the Palomar Transient Factory

NASA Astrophysics Data System (ADS)

Singer, Leo P.; Kasliwal, Mansi M.; Cenko, S. Bradley; Perley, Daniel A.; Anderson, Gemma E.; Anupama, G. C.; Arcavi, Iair; Bhalerao, Varun; Bue, Brian D.; Cao, Yi; Connaughton, Valerie; Corsi, Alessandra; Cucchiara, Antonino; Fender, Rob P.; Fox, Derek B.; Gehrels, Neil; Goldstein, Adam; Gorosabel, J.; Horesh, Assaf; Hurley, Kevin; Johansson, Joel; Kann, D. A.; Kouveliotou, Chryssa; Huang, Kuiyun; Kulkarni, S. R.; Masci, Frank; Nugent, Peter; Rau, Arne; Rebbapragada, Umaa D.; Staley, Tim D.; Svinkin, Dmitry; Thöne, C. C.; de Ugarte Postigo, A.; Urata, Yuji; Weinstein, Alan

2015-06-01

The Fermi Gamma-ray Space Telescope has greatly expanded the number and energy window of observations of gamma-ray bursts (GRBs). However, the coarse localizations of tens to a hundred square degrees provided by the Fermi GRB Monitor instrument have posed a formidable obstacle to locating the bursts’ host galaxies, measuring their redshifts, and tracking their panchromatic afterglows. We have built a target-of-opportunity mode for the intermediate Palomar Transient Factory in order to perform targeted searches for Fermi afterglows. Here, we present the results of one year of this program: 8 afterglow discoveries out of 35 searches. Two of the bursts with detected afterglows (GRBs 130702A and 140606B) were at low redshift (z = 0.145 and 0.384, respectively) and had spectroscopically confirmed broad-line Type Ic supernovae. We present our broadband follow-up including spectroscopy as well as X-ray, UV, optical, millimeter, and radio observations. We study possible selection effects in the context of the total Fermi and Swift GRB samples. We identify one new outlier on the Amati relation. We find that two bursts are consistent with a mildly relativistic shock breaking out from the progenitor star rather than the ultra-relativistic internal shock mechanism that powers standard cosmological bursts. Finally, in the context of the Zwicky Transient Facility, we discuss how we will continue to expand this effort to find optical counterparts of binary neutron star mergers that may soon be detected by Advanced LIGO and Virgo.

Vasovagal syncope in medical students and their first-degree relatives.

PubMed

Serletis, Anna; Rose, Sarah; Sheldon, Aaron G; Sheldon, Robert S

2006-08-01

To determine the effect of family history on the likelihood of vasovagal syncope. Sixty-two medical students and 228 first-degree relatives were studied. Vasovagal syncope was ascertained with the Calgary syncope symptom score. The effects of the sex of the subject and parental syncope history on the likelihood of offspring fainting were described using Kaplan-Meier estimates and analysed using proportional hazards regression. The prevalence of vasovagal syncope was 32% and the median age of first faint in those who fainted was 14 years. More females than males fainted [42 vs. 31%; P=0.02; hazard ratio (HR) 1.34 (95% CI 1.07-1.68)]. An individual with two fainting parents was more likely to faint than one with no fainting parents [P<0.0001; HR 3.4 (95% CI 1.7-7.03)]. In the proportional hazards model, offspring of either sex whose mother faints are more likely to faint than those whose mother does not faint [HR 2.86 (95% CI 1.54-5.31)]. Having a father who faints significantly increases the risk of syncope in sons [HR 4.12 (95%CI 1.39-12.31)], but not in daughters [HR 1.18 (95% CI 0.56-3.34)]. Family history and sex of subject are important predictors of vasovagal syncope in offspring.

Optical and Near-Infrared Observations of SN 2013DX Associated with GRB 130702A

NASA Technical Reports Server (NTRS)

Toy, V. L.; Cenko, S. B.; Silverman, J. M.; Butler, N. R.; Cucchiara, A.; Watson, A. M.; Bersier, D.; Perley, D. A.; Margutti, R.; Bellm, E.;

Wide-Field Gamma-Spectrometer BDRG: GRB Monitor On-Board the Lomonosov Mission

NASA Astrophysics Data System (ADS)

Svertilov, S. I.; Panasyuk, M. I.; Bogomolov, V. V.; Amelushkin, A. M.; Barinova, V. O.; Galkin, V. I.; Iyudin, A. F.; Kuznetsova, E. A.; Prokhorov, A. V.; Petrov, V. L.; Rozhkov, G. V.; Yashin, I. V.; Gorbovskoy, E. S.; Lipunov, V. M.; Park, I. H.; Jeong, S.; Kim, M. B.

2018-02-01

The study of GRB prompt emissions (PE) is one of the main goals of the Lomonosov space mission. The payloads of the GRB monitor (BDRG) with the wide-field optical cameras (SHOK) and the ultra-fast flash observatory (UFFO) onboard the Lomonosov satellite are intended for the observation of GRBs, and in particular, their prompt emissions. The BDRG gamma-ray spectrometer is designed to obtain the temporal and spectral information of GRBs in the energy range of 10-3000 keV as well as to provide GRB triggers on several time scales (10 ms, 1 s and 20 s) for ground and space telescopes, including the UFFO and SHOK. The BDRG instrument consists of three identical detector boxes with axes shifted by 90° from each other. This configuration allows us to localize a GRB source in the sky with an accuracy of ˜ 2°. Each BDRG box contains a phoswich NaI(Tl)/CsI(Tl) scintillator detector. A thick CsI(Tl) crystal in size of \\varnothing 130 × 17 mm is placed underneath the NaI(Tl) as an active shield in the soft energy range and as the main detector in the hard energy range. The ratio of the CsI(Tl) to NaI(Tl) event rates at varying energies can be employed as an independent metric to distinguish legitimate GRB signals from false positives originating from electrons in near-Earth vicinities. The data from three detectors are collected in a BA BDRG information unit, which generates a GRB trigger and a set of data frames in output format. The scientific data output is ˜ 500 Mb per day, including ˜ 180 Mb of continuous data for events with durations in excess of 100 ms for 16 channels in each detector, detailed energy spectra, and sets of frames with ˜ 5 Mb of detailed information for each burst-like event. A number of pre-flight tests including those for the trigger algorithm and calibration were carried out to confirm the reliability of the BDRG for operation in space.

Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

PubMed Central

Bazenet, C E; Gelderloos, J A; Kazlauskas, A

1996-01-01

Following binding of platelet-derived growth factor (PDGF), the PDGF alpha receptor (alphaPDGFR) becomes tyrosine phosphorylated and associates with a number of signal transduction molecules, including phospholipase Cgamma-1 (PLCgamma-1), phosphatidylinositol 3-kinase (PI3K), the phosphotyrosine phosphatase SHP-2, Grb2, and Src. Here, we present data identifying a novel phosphorylation site in the kinase insert domain of the alphaPDGFR at tyrosine (Y) 720. We replaced this residue with phenylalanine and expressed the mutated receptor (F720) in Patch fibroblasts that do not express the alphaPDGFR. Characterization of the F720 mutant indicated that binding of two proteins, SHP-2 and Grb2, was severely impaired, whereas PLCgamma-1 and PI3K associated to wild-type levels. In addition, mutating Y720 to phenylalanine dramatically reduced PDGF-dependent tyrosine phosphorylation of SHP-2. Since Y720 was required for recruitment of two proteins, we investigated the mechanism by which these two proteins associated with the alphaPDGFR. SHP-2 bound the alphaPDGFR directly, whereas Grb2 associated indirectly, most probably via SHP-2, as Grb2 and SHP-2 coimmunoprecipitated when SHP-2 was tyrosine phosphorylated. We also compared the ability of the wild-type and F720 alphaPDGFRs to mediate a number of downstream events. Preventing the alphaPDGFR from recruiting SHP-2 and Grb2 did not compromise PDGF-AA-induced activation of Ras, initiation of DNA synthesis, or growth of cells in soft agar. We conclude that phosphorylation of the alphaPDGFR at Y720 is required for association of SHP-2 and Grb2 and tyrosine phosphorylation of SHP-2; however, these events are not required for the alphaPDGFR to activate Ras or initiate a proliferative response. In addition, these findings reveal that while SHP-2 binds to both of the receptors, it binds in different locations: to the carboxy terminus of the betaPDGFR but to the kinase insert of the alphaPDGFR. PMID:8943348

Naked-eye optical flash from gamma-ray burst 080319B: Tracing the decaying neutrons in the outflow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan Yizhong; Zhang Bing; Wei Daming

For an unsteady baryonic gamma-ray burst (GRB) outflow, the fast and slow proton shells collide with each other and produce energetic soft gamma-ray emission. If the outflow has a significant neutron component, the ultrarelativistic neutrons initially expand freely until decaying at a larger radius. The late-time proton shells ejected from the GRB central engine, after powering the regular internal shocks, will sweep these {beta}-decay products and give rise to very bright UV/optical emission. The naked-eye optical flash from GRB 080319B, an energetic explosion in the distant Universe, can be well explained in this way.

Dark-ages reionization and galaxy formation simulation - X. The small contribution of quasars to reionization

NASA Astrophysics Data System (ADS)

Qin, Yuxiang; Mutch, Simon J.; Poole, Gregory B.; Liu, Chuanwu; Angel, Paul W.; Duffy, Alan R.; Geil, Paul M.; Mesinger, Andrei; Wyithe, J. Stuart B.

2017-12-01

Motivated by recent measurements of the number density of faint AGN at high redshift, we investigate the contribution of quasars to reionization by tracking the growth of central supermassive black holes in an update of the MERAXES semi-analytic model. The model is calibrated against the observed stellar mass function at z ∼ 0.6-7, the black hole mass function at z ≲ 0.5, the global ionizing emissivity at z ∼ 2-5 and the Thomson scattering optical depth. The model reproduces a Magorrian relation in agreement with observations at z < 0.5 and predicts a decreasing black hole mass towards higher redshifts at fixed total stellar mass. With the implementation of an opening angle of 80 deg for quasar radiation, corresponding to an observable fraction of ∼23.4 per cent due to obscuration by dust, the model is able to reproduce the observed quasar luminosity function at z ∼ 0.6-6. The stellar light from galaxies hosting faint active galactic nucleus (AGN) contributes a significant or dominant fraction of the UV flux. At high redshift, the model is consistent with the bright end quasar luminosity function and suggests that the recent faint z ∼ 4 AGN sample compiled by Giallongo et al. (2015) includes a significant fraction of stellar light. Direct application of this luminosity function to the calculation of AGN ionizing emissivity consequently overestimates the number of ionizing photons produced by quasars by a factor of 3 at z ∼ 6. We conclude that quasars are unlikely to make a significant contribution to reionization.

X-ray-bright optically faint active galactic nuclei in the Subaru Hyper Suprime-Cam wide survey

NASA Astrophysics Data System (ADS)

Terashima, Yuichi; Suganuma, Makoto; Akiyama, Masayuki; Greene, Jenny E.; Kawaguchi, Toshihiro; Iwasawa, Kazushi; Nagao, Tohru; Noda, Hirofumi; Toba, Yoshiki; Ueda, Yoshihiro; Yamashita, Takuji

2018-01-01

We construct a sample of X-ray-bright optically faint active galactic nuclei by combining Subaru Hyper Suprime-Cam, XMM-Newton, and infrared source catalogs. Fifty-three X-ray sources satisfying i-band magnitude fainter than 23.5 mag and X-ray counts with the EPIC-PN detector larger than 70 are selected from 9.1 deg2, and their spectral energy distributions (SEDs) and X-ray spectra are analyzed. Forty-four objects with an X-ray to i-band flux ratio FX/Fi > 10 are classified as extreme X-ray-to-optical flux sources. Spectral energy distributions of 48 among 53 are represented by templates of type 2 AGNs or star-forming galaxies and show the optical signature of stellar emission from host galaxies in the source rest frame. Infrared/optical SEDs indicate a significant contribution of emission from dust to the infrared fluxes, and that the central AGN is dust obscured. The photometric redshifts determined from the SEDs are in the range of 0.6-2.5. The X-ray spectra are fitted by an absorbed power-law model, and the intrinsic absorption column densities are modest (best-fit log NH = 20.5-23.5 cm-2 in most cases). The absorption-corrected X-ray luminosities are in the range of 6 × 1042-2 × 1045 erg s-1. Twenty objects are classified as type 2 quasars based on X-ray luminsosity and NH. The optical faintness is explained by a combination of redshifts (mostly z > 1.0), strong dust extinction, and in part a large ratio of dust/gas.

CROSS-CORRELATION OF NEAR- AND FAR-INFRARED BACKGROUND ANISOTROPIES AS TRACED BY SPITZER AND HERSCHEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thacker, Cameron; Gong, Yan; Cooray, Asantha

We present the cross-correlation between the far-infrared (far-IR) background fluctuations as measured with the Herschel Space Observatory at 250, 350, and 500 μm and the near-infrared (near-IR) background fluctuations with the Spitzer Space Telescope at 3.6 and 4.5 μm. The cross-correlation between the FIR and NIR background anisotropies is detected such that the correlation coefficient at a few to 10 arcminute angular scale decreases from 0.3 to 0.1 when the FIR wavelength increases from 250 to 500 μm. We model the cross-correlation using a halo model with three components: (a) FIR bright or dusty star-forming galaxies below the masking depth inmore » Herschel maps, (b) NIR faint galaxies below the masking depth, and (c) intra-halo light (IHL), or diffuse stars in dark matter halos, that is likely dominating the large-scale NIR fluctuations. The model is able to reasonably reproduce the auto-correlations at each of the FIR wavelengths and at 3.6 μm and their corresponding cross-correlations. While the FIR and NIR auto-correlations are dominated by faint, dusty, star-forming galaxies and IHL, respectively, we find that roughly half of the cross-correlation between the NIR and FIR backgrounds is due to the same dusty galaxies that remain unmasked at 3.6 μm. The remaining signal in the cross-correlation is due to IHL present in the same dark matter halos as those hosting the same faint and unmasked galaxies.« less

VizieR Online Data Catalog: GRB 120327A afterglow colour variations (Melandri+, 2017)

NASA Astrophysics Data System (ADS)

Melandri, A.; Covino, S.; Zaninoni, E.; Campana, S.; Bolmer, J.; Cobb, B. E.; Gorosabel, J.; Kim, J.-W.; Kuin, P.; Kuroda, D.; Malesani, D.; Mundell, C. G.; Nappo, F.; Sbarufatti, B.; Smith, R. J.; Steele, I. A.; Topinka, M.; Trotter, A. S.; Virgili, F. J.; Bernardini, M. G.; D'Avanzo, P.; D'Elia, V.; Fugazza, D.; Ghirlanda, G.; Gomboc, A.; Greiner, J.; Guidorzi, C.; Haislip, J. B.; Hanayama, H.; Hanlon, L.; Im, M.; Ivarsen, K. M.; Japelj, J.; Jelinek, M.; Kawai, N.; Kobayashi, S.; Kopac, D.; Lacluyze, A. P.; Martin-Carrillo, A.; Murphy, D.; Reichart, D. E.; Salvaterra, R.; Salafia, O. S.; Tagliaferri, G.; Vergani, S. D.

2017-09-01

Photometric data of GRB120327A are presented. Magnitudes are in the Vega system unless for griz filters that are in the AB system, and they are all not corrected for Galactic absorption. Errors are at 1sigma level. (1 data file).

Prompt Neutrino Emission of Gamma-ray Bursts in the Dissipative Photospheric Scenario Revisited: Possible Contributions from Cocoons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, Di; Dai, Zi-Gao; Mészáros, Peter, E-mail: dzg@nju.edu.cn

2017-07-01

High-energy neutrinos are expected to originate from different stages in a gamma-ray burst (GRB) event. In this work, we revisit the dissipative photospheric scenario, in which the GRB prompt emission is produced around the photospheric radius. Meanwhile, possible dissipation mechanisms (e.g., internal shocks or magnetic reconnection) could accelerate cosmic-rays (CRs) to ultra-high energies and then produce neutrinos via hadronuclear and photohadronic processes, which are referred to as prompt neutrinos . In this paper, we obtain the prompt neutrino spectrum of a single GRB within a self-consistent analytical framework, in which the jet-cocoon structure and possible collimation effects are included. Wemore » investigate a possible neutrino signal from the cocoon, which has been ignored in the previous studies. We show that if a GRB event happens at a distance of the order of Mpc, there is a great chance to observe the neutrino emission from the cocoon by IceCube, which is even more promising than jet neutrinos, as the opening angle of the cocoon is much larger. We also determine the diffuse neutrino flux of GRB cocoons and find that it could be comparable with that of the jets. Our results are consistent with the latest result reported by the IceCube collaboration that no significant correlation between neutrino events and observed GRBs is seen in the new data.« less

A Collapsar Model with Disk Wind: Implications for Supernovae Associated with Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Hayakawa, Tomoyasu; Maeda, Keiichi

2018-02-01

We construct a simple but self-consistent collapsar model for gamma-ray bursts (GRBs) and SNe associated with GRBs (GRB-SNe). Our model includes a black hole, an accretion disk, and the envelope surrounding the central system. The evolutions of the different components are connected by the transfer of the mass and angular momentum. To address properties of the jet and the wind-driven SNe, we consider competition of the ram pressure from the infalling envelope and those from the jet and wind. The expected properties of the GRB jet and the wind-driven SN are investigated as a function of the progenitor mass and angular momentum. We find two conditions that should be satisfied if the wind-driven explosion is to explain the properties of the observed GRB-SNe: (1) the wind should be collimated at its base, and (2) it should not prevent further accretion even after the launch of the SN explosion. Under these conditions, some relations seen in the properties of the GRB-SNe could be reproduced by a sequence of different angular momentum in the progenitors. Only the model with the largest angular momentum could explain the observed (energetic) GRB-SNe, and we expect that the collapsar model can result in a wide variety of observational counterparts, mainly depending on the angular momentum of the progenitor star.

The Supercritical Pile GRB Model: The Prompt to Afterglow Evolution

NASA Technical Reports Server (NTRS)

Mastichiadis, A.; Kazanas, D.

2009-01-01

The "Supercritical Pile" is a very economical GRB model that provides for the efficient conversion of the energy stored in the protons of a Relativistic Blast Wave (RBW) into radiation and at the same time produces - in the prompt GRB phase, even in the absence of any particle acceleration - a spectral peak at energy approx. 1 MeV. We extend this model to include the evolution of the RBW Lorentz factor Gamma and thus follow its spectral and temporal features into the early GRB afterglow stage. One of the novel features of the present treatment is the inclusion of the feedback of the GRB produced radiation on the evolution of Gamma with radius. This feedback and the presence of kinematic and dynamic thresholds in the model can be the sources of rich time evolution which we have began to explore. In particular. one can this may obtain afterglow light curves with steep decays followed by the more conventional flatter afterglow slopes, while at the same time preserving the desirable features of the model, i.e. the well defined relativistic electron source and radiative processes that produce the proper peak in the (nu)F(sub nu), spectra. In this note we present the results of a specific set of parameters of this model with emphasis on the multiwavelength prompt emission and transition to the early afterglow.

A New Search Paradigm for Correlated Neutrino Emission from Discrete GRBs using Antarctic Cherenkov Telescopes in the Swift Era

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stamatikos, Michael; Band, David L.; JCA/UMBC, Baltimore, MD 21250

2006-05-19

We describe the theoretical modeling and analysis techniques associated with a preliminary search for correlated neutrino emission from GRB980703a, which triggered the Burst and Transient Source Experiment (BATSE GRB trigger 6891), using archived data from the Antarctic Muon and Neutrino Detector Array (AMANDA-B10). Under the assumption of associated hadronic acceleration, the expected observed neutrino energy flux is directly derived, based upon confronting the fireball phenomenology with the discrete set of observed electromagnetic parameters of GRB980703a, gleaned from ground-based and satellite observations, for four models, corrected for oscillations. Models 1 and 2, based upon spectral analysis featuring a prompt photon energymore » fit to the Band function, utilize an observed spectroscopic redshift, for isotropic and anisotropic emission geometry, respectively. Model 3 is based upon averaged burst parameters, assuming isotropic emission. Model 4 based upon a Band fit, features an estimated redshift from the lag-luminosity relation, with isotropic emission. Consistent with our AMANDA-II analysis of GRB030329, which resulted in a flux upper limit of {approx} 0.150GeV /cm2/s for model 1, we find differences in excess of an order of magnitude in the response of AMANDA-B10, among the various models for GRB980703a. Implications for future searches in the era of Swift and IceCube are discussed.« less

High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

PubMed

Higo, Kunitake; Ikura, Teikichi; Oda, Masayuki; Morii, Hisayuki; Takahashi, Jun; Abe, Ryo; Ito, Nobutoshi

2013-01-01

Src homology 2 (SH2) domains play a critical role in cellular signal transduction. They bind to peptides containing phosphotyrosine (pY) with various specificities that depend on the flanking amino-acid residues. The SH2 domain of growth-factor receptor-bound protein 2 (Grb2) specifically recognizes pY-X-N-X, whereas the SH2 domains in phosphatidylinositol 3-kinase (PI3K) recognize pY-X-X-M. Binding of the pY site in CD28 (pY-M-N-M) by PI3K and Grb2 through their SH2 domains is a key step that triggers the CD28 signal transduction for T cell activation and differentiation. In this study, we determined the crystal structure of the Grb2 SH2 domain in complex with a pY-containing peptide derived from CD28 at 1.35 Å resolution. The peptide was found to adopt a twisted U-type conformation, similar to, but distinct from type-I β-turn. In all previously reported crystal structures, the peptide bound to the Grb2 SH2 domains adopts a type-I β-turn conformation, except those with a proline residue at the pY+3 position. Molecular modeling also suggests that the same peptide bound to PI3K might adopt a very different conformation.

Dwarf Hosts of Low-z Supernovae

NASA Astrophysics Data System (ADS)

Pyotr Kolobow, Craig; Perlman, Eric S.; Strolger, Louis

2018-01-01

Hostless supernovae (SNe), or SNe in dwarf galaxies, may serve as excellent beacons for probing the spatial density of dwarf galaxies (M < 10^8M⊙), which themselves are scarcely detected beyond only a few Mpc. Depending on the assumed model for the stellar-mass to halo mass relation for these galaxies, LSST might see 1000s of SNe (of all types) from dwarf galaxies alone. Conversely, one can take the measured rates of these SNe and test the model predictions for the density of dwarf galaxies in the local universe. Current “all-sky” surveys, like PanSTARRS and ASAS-SN, are now finding hostless SNe at a number sufficient to measure their rate. What missing is the appropriate weighting of their host luminosities. Here we seek to continue a successful program to recover the luminosities of these hostless SNe, to z = 0.15, to use their rate to constrain the faint-end slope of the low-z galaxy luminosity function.

A method to directly image exoplanets in multi-star systems such as Alpha-Centauri

NASA Astrophysics Data System (ADS)

Thomas, Sandrine J.; Belikov, Ruslan; Bendek, Eduardo

2015-09-01

Direct imaging of extra-solar planets is now a reality, especially with the deployment and commissioning of the first generation of specialized ground-based instruments such as the Gemini Planet Imager and SPHERE. These systems will allow detection of Jupiter-like planets 107 times fainter than their host star. Obtaining this contrast level and beyond requires the combination of a coronagraph to suppress light coming from the host star and a wavefront control system including a deformable mirror (DM) to remove residual starlight (speckles) created by the imperfections of telescope. However, all these current and future systems focus on detecting faint planets around single host stars, while several targets or planet candidates are located around nearby binary stars such as our neighboring star Alpha Centauri. Here, we present a method to simultaneously correct aberrations and diffraction of light coming from the target star as well as its companion star in order to reveal planets orbiting the target star. This method works even if the companion star is outside the control region of the DM (beyond its half-Nyquist frequency), by taking advantage of aliasing effects.

Direct imaging of exoplanets around multiple star systems

NASA Astrophysics Data System (ADS)

Thomas, Sandrine

2015-01-01

Direct imaging of extra-solar planets is now a reality, especially with the deployment and commissioning of the first generation of specialized ground-based instruments such as the Gemini Planet Imager and SPHERE. These systems will allow detection of Jupiter-like planets 10^7 times fainter than their host star. Obtaining this contrast level and beyond requires the combination of a coronagraph to suppress light coming from the host star and a wavefront control system including a deformable mirror (DM) to remove residual starlight (speckles) created by the imperfections of telescope. However, all these current and future systems focus on detecting faint planets around a single host star or unresolved binaries/multiples, while several targets or planet candidates are located around nearby binary stars such as our neighboring star Alpha Centauri.Here, we present a method to simultaneously correct aberrations and diffraction of light coming from the target star as well as its companion star in order to reveal planets orbiting the target star. This method works even if the companion star is outside the control region of the DM (beyond its half-Nyquist frequency), by taking advantage of aliasing effects.

30 years of Gamma Ray Bursts and the Transient High Energy Sky

NASA Technical Reports Server (NTRS)

Kouveliotou, Chryssa

2009-01-01

The first GRB was discovered on 1967, just over 40 years ago. It took several years and multiple generations of space and ground instruments to unravel some of the mysteries of this phenomenon. However, many questions remain open today. I will discuss the history, evolution and current status of the GRB field and its contributions in our understanding of the transient high energy sky. Further, I will discuss my involvement with the discovery of magnetars, neutron stars with extreme magnetic fields, serendipitously detected by GRB observers on 1979. Finally, I will describe how GRBs can be utilized in future missions as tools, to probe the cosmic chemical evolution of the Universe.

A new software on TUG-T60 autonomous telescope for astronomical transient events

NASA Astrophysics Data System (ADS)

Dindar, Murat; Helhel, Selçuk; Esenoğlu, Hasan; Parmaksızoğlu, Murat

2015-03-01

Robotic telescopes usually run under the control of a scheduler, which provides high-level control by selecting astronomical targets for observation. TÜBİTAK (Scientific and Technological Research Council of Turkey) National Observatory (TUG)-T60 Robotic Telescope is controlled by open-source OCAAS software, formally named Talon. This study introduces new software which was designed for Talon to catch GRB, GAIA and transient alerts. The new GRB software module (daemon process) alertd is running with all other modules of Talon such as telescoped; focus, dome; camerad and telrun. Maximum slew velocity and acceleration limits of the T60 telescope are enough fast for the GRB and transient observations.

X-Ray and Multi-Wavelength Observations of Gamma Ray Bursts (GRBs)

NASA Technical Reports Server (NTRS)

Kouveliotou, Chryssa

2009-01-01

The launch of the Italian (with Dutch participation) satellite BeppoSAX in 1996 enabled the detection of the first X-ray GRB afterglow, which in turn led to GRB counterpart detection in multiple wavelengths. This breakthrough firmly established the cosmological nature of GRBs. However, afterglow observations of GRBs took off in large numbers after the launch of NASA's Swift satellite in 2004. Swift enabled multiple major discoveries, such as the early lightcurves of X-ray afterglows, the first detection of a short GRB afterglow and opened more questions such as where are the elusive breaks in afterglow light curves. I will describe here these results and will discuss future opportunities and improvements in the field.

The optical rebrightening of GRB100814A: an interplay of forward and reverse shocks?

NASA Astrophysics Data System (ADS)

De Pasquale, Massimiliano; Kuin, N. P. M.; Oates, S.; Schulze, S.; Cano, Z.; Guidorzi, C.; Beardmore, A.; Evans, P. A.; Uhm, Z. L.; Zhang, B.; Page, M.; Kobayashi, S.; Castro-Tirado, A.; Gorosabel, J.; Sakamoto, T.; Fatkhullin, T.; Pandey, S. B.; Im, M.; Chandra, P.; Frail, D.; Gao, H.; Kopač, D.; Jeon, Y.; Akerlof, C.; Huang, K. Y.; Pak, S.; Park, W.-K.; Gomboc, A.; Melandri, A.; Zane, S.; Mundell, C. G.; Saxton, C. J.; Holland, S. T.; Virgili, F.; Urata, Y.; Steele, I.; Bersier, D.; Tanvir, N.; Sokolov, V. V.; Moskvitin, A. S.

2015-05-01

We present a wide data set of gamma-ray, X-ray, UV/Opt/IR (UVOIR), and radio observations of the Swift GRB100814A. At the end of the slow decline phase of the X-ray and optical afterglow, this burst shows a sudden and prominent rebrightening in the optical band only, followed by a fast decay in both bands. The optical rebrightening also shows chromatic evolution. Such a puzzling behaviour cannot be explained by a single component model. We discuss other possible interpretations, and we find that a model that incorporates a long-lived reverse shock and forward shock fits the temporal and spectral properties of GRB100814 the best.

CFS Products

Science.gov Websites

vddsf.xx.YYYYMMDDHH.daily.grb2 Not Available CFS Near IR Diffuse Downward Solar Flux Filename Inventory Available CFS Near IR Diffuse Downward Solar Flux Filename Inventory nddsf.xx.YYYYMMDDHH.daily.grb2 6hrly Image of NCEP logo For questions related to this website, send mail to Web Manager. NCEP/NCO Production

Swift Data Products in GCN

NASA Astrophysics Data System (ADS)

Barthelmy, Scott D.

2006-09-01

The Swift mission produces a much larger range of data products for the GRB Coordinates Distribution (GCN) system than any previous mission. Beyond the normal position-containing notices, the extra products are lightcurves, spectra, and images. We will present examples of these new data products and how they can be used to guide GRB follow-up observation campaigns.

Smooth Optical Self-similar Emission of Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Lipunov, Vladimir; Simakov, Sergey; Gorbovskoy, Evgeny; Vlasenko, Daniil

2017-08-01

We offer a new type of calibration for gamma-ray bursts (GRB), in which some class of GRB can be marked and share a common behavior. We name this behavior Smooth Optical Self-similar Emission (SOS-similar Emission) and identify this subclasses of GRBs with optical light curves described by a universal scaling function.

A MAD Explanation for the Correlation between Bulk Lorentz Factor and Minimum Variability Timescale

NASA Astrophysics Data System (ADS)

Lloyd-Ronning, Nicole; Lei, Wei-hua; Xie, Wei

2018-04-01

We offer an explanation for the anti-correlation between the minimum variability timescale (MTS) in the prompt emission light curve of gamma-ray bursts (GRBs) and the estimated bulk Lorentz factor of these GRBs, in the context of a magnetically arrested disk (MAD) model. In particular, we show that previously derived limits on the maximum available energy per baryon in a Blandford-Znajek jet leads to a relationship between the characteristic MAD timescale in GRBs and the maximum bulk Lorentz factor: tMAD∝Γ-6, somewhat steeper than (although within the error bars of) the fitted relationship found in the GRB data. Similarly, the MAD model also naturally accounts for the observed anti-correlation between MTS and gamma-ray luminosity L in the GRB data, and we estimate the accretion rates of the GRB disk (given these luminosities) in the context of this model. Both of these correlations (MTS - Γ and MTS - L) are also observed in the AGN data, and we discuss the implications of our results in the context of both GRB and blazar systems.

The optical afterglow of the short gamma-ray burst GRB 050709.

PubMed

Hjorth, Jens; Watson, Darach; Fynbo, Johan P U; Price, Paul A; Jensen, Brian L; Jørgensen, Uffe G; Kubas, Daniel; Gorosabel, Javier; Jakobsson, Páll; Sollerman, Jesper; Pedersen, Kristian; Kouveliotou, Chryssa

2005-10-06

It has long been known that there are two classes of gamma-ray bursts (GRBs), mainly distinguished by their durations. The breakthrough in our understanding of long-duration GRBs (those lasting more than approximately 2 s), which ultimately linked them with energetic type Ic supernovae, came from the discovery of their long-lived X-ray and optical 'afterglows', when precise and rapid localizations of the sources could finally be obtained. X-ray localizations have recently become available for short (duration <2 s) GRBs, which have evaded optical detection for more than 30 years. Here we report the first discovery of transient optical emission (R-band magnitude approximately 23) associated with a short burst: GRB 050709. The optical afterglow was localized with subarcsecond accuracy, and lies in the outskirts of a blue dwarf galaxy. The optical and X-ray afterglow properties 34 h after the GRB are reminiscent of the afterglows of long GRBs, which are attributable to synchrotron emission from ultrarelativistic ejecta. We did not, however, detect a supernova, as found in most nearby long GRB afterglows, which suggests a different origin for the short GRBs.

The Origin of the Optical Flashes: The Case Study of GRB 080319B and GRB 130427A

NASA Astrophysics Data System (ADS)

Fraija, N.; Veres, P.

2018-05-01

Correlations between optical flashes and gamma-ray emissions in gamma-ray bursts (GRBs) have been searched in order to clarify the question of whether these emissions occur at internal and/or external shocks. Among the most powerful GRBs ever recorded are GRB 080319B and GRB 130427A, which at early phases presented bright optical flashes possibly correlated with γ-ray components. Additionally, both bursts were fortuitously located within the field of view of the TeV γ-ray Milagro and HAWC observatories, and although no statistically significant excess of counts were collected, upper limits were placed on the GeV–TeV emission. Considering the synchrotron self-Compton emission from internal shocks and requiring the GeV–TeV upper limits, we found that the optical flashes and the γ-ray components are produced by different electron populations. Analyzing the optical flashes together with the multiwavelength afterglow observation, we found that these flashes can be interpreted in the framework of the synchrotron reverse shock model when outflows have arbitrary magnetizations.

Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.

PubMed

Schiering, N; Casale, E; Caccia, P; Giordano, P; Battistini, C

2000-11-07

Src homology 2 (SH2) domains are key modules in intracellular signal transduction. They link activated cell surface receptors to downstream targets by binding to phosphotyrosine-containing sequence motifs. The crystal structure of a Grb2-SH2 domain-phosphopeptide complex was determined at 2.4 A resolution. The asymmetric unit contains four polypeptide chains. There is an unexpected domain swap so that individual chains do not adopt a closed SH2 fold. Instead, reorganization of the EF loop leads to an open, nonglobular fold, which associates with an equivalent partner to generate an intertwined dimer. As in previously reported crystal structures of canonical Grb2-SH2 domain-peptide complexes, each of the four hybrid SH2 domains in the two domain-swapped dimers binds the phosphopeptide in a type I beta-turn conformation. This report is the first to describe domain swapping for an SH2 domain. While in vivo evidence of dimerization of Grb2 exists, our SH2 dimer is metastable and a physiological role of this new form of dimer formation remains to be demonstrated.

Gamma-Ray Burst Spectral Indices: Evidence for Deceleration of Synchrotron Shocks

NASA Technical Reports Server (NTRS)

Preece, R. D.; Briggs, M. S.; Giblin, T.; Mallozzi, R. S.; Pendleton, G. N.; Paciesas, W. S.; Band, D. L.

2000-01-01

The current scenario for gamma-ray bursts (GRBs) involves internal shocks for the prompt GRB emission phase and external shocks for the afterglow phase. Assuming synchrotron emission from energetic shocked electrons. GRB spectra observed with a low-energy power-law spectral index greater than -2/3 (for positive photon number indices E(sup alpha) indicate a problem with this model. The remaining spectra can test the synchrotron shock model prediction that the emission from a single distribution of electrons, cooling rapidly, is responsible for both the low-energy and high-energy power-low portions of the spectra. We find that the inferred relationship between the two spectral indices of observed GRB spectra is inconsistent with the constraints from the model, posing another problem for the synchrotron shock emission model. To overcome this problem, we describe a model where the average of -1, rather than the value of -3/2 predicted for cooling electrons. Situations where this might arise have been discussed in other contexts, and involve deceleration of the internal shocks during the GRB phase.

Implications for the Origin of GRB 051103 from LIGO Observations

NASA Technical Reports Server (NTRS)

Bizouard, M. A.; Dietz, A.; Guidi, G. M.; Was, M.; Camp, J. B.; Cannizzo, J.; Stroeer, A. S.; Blackburn, L.

2012-01-01

We present the results of a LIGO search for gravitational waves (GWs) associated with GRB 051103, a short-duration hard-spectrum gamma-ray burst whose electromagnetically determined sky position is coincident with the spiral galaxy M81, which is 3.6Mpc from Earth. Possible progenitors for short-hard GRBs include compact object mergers and soft gamma repeater (SGR) giant flares. A merger progenitor would produce a characteristic GW signal that should be detectable at the distance of M81, while GW emission from an SGR is not expected to be detectable at that distance. We found no evidence of a GW signal associated with GRB 051103. Assuming weakly beamed gamma-ray emission with a jet semi-angle of 30. we exclude a binary neutron star merger in M81 as the progenitor with a confidence of 98%. Neutron star-black hole mergers are excluded with > 99% confidence. If the event occurred in M81 our findings support the hypothesis that GRB 051103 was due to an SGR giant flare, making it the most distant extragalactic magnetar observed to date.

Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel.

PubMed

Gril, Brunilde; Vidal, Michel; Assayag, Franck; Poupon, Marie-France; Liu, Wang-Qing; Garbay, Christiane

2007-07-15

HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras-dependent signaling induced by HER2 receptors. A specific Grb2-SH3 ligand, designed and synthesized in our laboratory, called peptidimer-c, inhibited colony formation in HER2 overexpressing SKBr3 cancer cells. Combined treatment of peptidimer-c with docetaxel further inhibited both colony formation and tumor cell survival compared to docetaxel treatment alone. Efficacy of this combined treatment was correlated with a reduction in the phosphorylation of MAPK and AKT. Finally, peptidimer-c reduced the growth of a HER2(+) human breast cancer (BK111) xenograft in nude mice and potentiated the antitumor effect of docetaxel in a HER2+ hormone-independent human prostate adenocarcinoma (PAC120 HID28) xenograft. These results validate Grb2 as a new target for the HER2 pathway. (c) 2007 Wiley-Liss, Inc.

Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel

PubMed Central

Gril, Brunilde; Vidal, Michel; Assayag, Franck; Poupon, Marie-France; Liu, Wang-Qing; Garbay, Christiane

2007-01-01

HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras-dependent signaling induced by HER2 receptors. A specific Grb2-SH3 ligand, designed and synthesized in our laboratory, called peptidimer-c, inhibited colony formation in HER2 over-expressing SKBr3 cancer cells. Combined treatment of peptidimer-c with docetaxel further inhibited both colony formation and tumor cell survival compared to docetaxel treatment alone. Efficacy of this combined treatment was correlated with a reduction in the phosphorylation of MAPK and AKT. Finally, peptidimer-c reduced the growth of a HER2+ human breast cancer (BK111) xenograft in nude mice and potentiated the anti-tumor effect of docetaxel in a HER2+ hormone-independent human prostate adenocarcinoma (PAC120 HID28) xenograft. These results validate Grb2 as a new target for the HER2 pathway. PMID:17372910

AzTEC/ASTE 1.1 mm Deep Surveys: Number Counts and Clustering of Millimeter-bright Galaxies

NASA Astrophysics Data System (ADS)

Hatsukade, B.

2011-11-01

We present results of a 1.1 mm deep survey of the AKARI Deep Field South (ADF-S) with AzTEC mounted on the Atacama Submillimetre Telescope Experiment (ASTE). We obtained a map of 0.25 deg2 area with an rms noise level of 0.32-0.71 mJy. This is one of the deepest and widest maps thus far at millimetre and submillimetre wavelengths. We uncovered 198 sources with a significance of 3.5-15.6σ, providing the largest catalog of 1.1 mm sources in a contiguous region. Most of the sources are not detected in the far-infrared bands of the AKARI satellite, suggesting that they are mostly at z ≥ 1.5 given the detection limits. We construct differential and cumulative number counts of the ADF-S, the Subaru/XMM Newton Deep Field (SXDF), and the SSA 22 field surveyed by AzTEC/ASTE, which provide currently the tightest constraints on the faint end. The integration of the differential number counts of the ADF-S find that the contribution of 1.1 mm sources with ≥1 mJy to the cosmic infrared background (CIB) at 1.1 mm is 12-16%, suggesting that the large fraction of the CIB originates from faint sources of which number counts are not yet constrained. We estimate the cosmic star-formation rate density contributed by 1.1 mm sources with ≥1 mJy using the differential number counts and find that it is lower by about a factor of 5-10 compared to those derived from UV/optically-selected galaxies at z ~ 2-3. Clustering analyses of AzTEC sources in the ADF-S and the SXDF find that bright (>3 mJy) AzTEC sources are more strongly clustered than faint (< 3 mJy) AzTEC sources and the average mass of dark halos hosting bright AzTEC sources was calculated to be 1013-1014M⊙. Comparison of correlation length of AzTEC sources with other populations and with a bias evolution model suggests that dark halos hosting bright AzTEC sources evolve into systems of clusters at present universe and the AzTEC sources residing the dark halos evolve into massive elliptical galaxies located in the center of clusters.

The Subaru/XMM-Newton Deep Survey (SXDS). V. Optically Faint Variable Object Survey

NASA Astrophysics Data System (ADS)

Morokuma, Tomoki; Doi, Mamoru; Yasuda, Naoki; Akiyama, Masayuki; Sekiguchi, Kazuhiro; Furusawa, Hisanori; Ueda, Yoshihiro; Totani, Tomonori; Oda, Takeshi; Nagao, Tohru; Kashikawa, Nobunari; Murayama, Takashi; Ouchi, Masami; Watson, Mike G.; Richmond, Michael W.; Lidman, Christopher; Perlmutter, Saul; Spadafora, Anthony L.; Aldering, Greg; Wang, Lifan; Hook, Isobel M.; Knop, Rob A.

2008-03-01

We present our survey for optically faint variable objects using multiepoch (8-10 epochs over 2-4 years) i'-band imaging data obtained with Subaru Suprime-Cam over 0.918 deg2 in the Subaru/XMM-Newton Deep Field (SXDF). We found 1040 optically variable objects by image subtraction for all the combinations of images at different epochs. This is the first statistical sample of variable objects at depths achieved with 8-10 m class telescopes or the Hubble Space Telescope. The detection limit for variable components is i'vari ~ 25.5 mag. These variable objects were classified into variable stars, supernovae (SNe), and active galactic nuclei (AGNs), based on the optical morphologies, magnitudes, colors, and optical-mid-infrared colors of the host objects, spatial offsets of variable components from the host objects, and light curves. Detection completeness was examined by simulating light curves for periodic and irregular variability. We detected optical variability for 36% +/- 2% (51% +/- 3% for a bright sample with i' < 24.4 mag) of X-ray sources in the field. Number densities of variable objects as functions of time intervals Δ t and variable component magnitudes i'vari are obtained. Number densities of variable stars, SNe, and AGNs are 120, 489, and 579 objects deg-2, respectively. Bimodal distributions of variable stars in the color-magnitude diagrams indicate that the variable star sample consists of bright (V ~ 22 mag) blue variable stars of the halo population and faint (V ~ 23.5 mag) red variable stars of the disk population. There are a few candidates of RR Lyrae providing a possible number density of ~10-2 kpc-3 at a distance of >150 kpc from the Galactic center. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based on observations (program GN-2002B-Q-30) obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (US), the Particle Physics and Astronomy Research Council (UK), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), CNPq (Brazil), and CONICET (Argentina).

Hubble Space Telescope Images of Nearby Luminous Quasars. 2; Results for Eight Quasars and Tests of the Detection Sensitivity

NASA Technical Reports Server (NTRS)

Bahcall, John N.; Kirhakos, Sofia; Schneider, Donald P.

1995-01-01

Observations with the Wide-Field Camera of the Hubble Space Telescope (HST) are presented for eight intrinsically luminous quasars with redshifts between 0.16 and 0.29. These observations, when combined with a similar HST study of the quasar PKS 2349-014, show that luminous nearby quasars exist in a variety of environments. Seven companion galaxies brighter than M(V) = 16.5 (H(sub 0) = 100 km s(sup -1) Mpc(sup -1), Omega(sub 0) = 1.0) lie within a projected distance of 25 kpc of the quasars; three of the companions are located closer than 3'' (6 kpc projected distance) from the quasars, well within the volume that would be enclosed by a typical L* host galaxy. The observed association of quasars and companion galaxies is statistically significant and may he an important element in the luminous-quasar phenomenon. Apparent host galaxies are detected for three of the quasars: PG 1116+215, 3C 273, and PG 1444+407; the hosts have an average absolute magnitude of about 0.6 mag brighter than L*. The agreement between the previously published major-axis directions in ground-based images and in the present HST images of 3C 273 and PG 1444+407 constitutes important evidence supporting the reality of these candidate host galaxies. Upper limits are placed on the visual-band brightnesses of representative galactic hosts for all the quasars. These limits are established by placing galaxy images obtained with HST underneath the quasars and measuring at what faintness level the known galaxies are detected. On average, the HST spirals would have been detected if they were as faint as 1 mag below L*, and the early-type galaxies could have been detected down to a brightness level of about L*, where L* is the Schechter characteristic luminosity of field galaxies. Smooth, featureless galaxy models (exponential disks or de Vaucouleurs profiles) are fitted to the residual light after a best-fitting point source is subtracted from the quasar images. The results show that smooth spiral galaxies brighter than, on average, about L*, would have been detected. These upper limits, or possible detections, are consistent with, for example, the eight luminous quasars studied in this paper, occurring in host galaxies that have a Shechter luminosity function with a lower cutoff in the range 0.01-0.1 L*. Tests are performed to determine if our failure to detect, in some cases, luminous host galaxies could be an artifact caused by our analysis procedures. These tests include comparing the measured point-spread function (PSF) for our HST observations with the PSFs used in previous ground-based studies of host galaxies, measuring the fluctuations in the sky signals that were subtracted from the quasar images, evaluating empirically the effects of using different stellar PSFs in the analysis, carrying out the subtraction of the stellar (nuclear) source in different ways, creating and analyzing artificial active galactic nuclei (AGNs) with known surface brightnesses, and fitting the observed quasar light to an analytic model that includes a host galaxy.

The correlation between malaria RDT (Paracheck pf.®) faint test bands and microscopy in the diagnosis of malaria in Malawi.

PubMed

Makuuchi, Ryoko; Jere, Sandy; Hasejima, Nobuchika; Chigeda, Thoms; Gausi, January

2017-05-02

Faint test bands of Paracheck Pf.® are interpreted as malaria positive according to world health organization (WHO) guideline. However if there are conspicuous number of faint test bands, a performance of Paracheck Pf.® could be influenced depending on whether interpreting faint test bands as malaria positive or negative. Finding out the frequency and accurate interpretation of faint test bands are important to prevent the overdiagnosis and drug resistance. A cross-sectional, descriptive study was conducted to find out the frequency of faint test bands and evaluate the performance of Paracheck Pf.® by sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of diagnosis of Paracheck Pf.® using microscopy as the gold standard. 388 suspected patients with malaria in Malawi were recruited in this study. Malaria rapid diagnostic tests (RDTs) and microscopy were used and patients' information which includes age, sex, body temperature and signs or symptoms of malaria were recorded. Among all patients involved in the study, 29.1% (113/388) were found malaria positive by RDT. Overall 5.4% (21/388) of all Paracheck Pf.® tests resulted in a "faint test band" and 85.7% (18/21) corresponded with malaria negative by microscopy. Faint test bands which corresponded with malaria positive by microscopy were lower parasite density and there are no patients who showed definitive symptom of malaria, such as fever. When Paracheck Pf.® "faint test bands" were classified as positive, accuracy of diagnosis was 76.5% (95% CI 72%-80.7%) as compared to 80.4% (95% CI 76.1%-84.2%) when Paracheck Pf.® "faint test bands" were classified as negative. This study shows that frequency of faint test bands is 5.4% in all malaria RDTs. The accuracy of diagnosis was improved when faint test bands were interpreted as malaria negative. However information and data obtained in this study may not be enough and more intensive research including a frequency and property of faint test bands is needed for significant interpretation of faint test bands.

UBAT of UFFO/ Lomonosov: The X-Ray Space Telescope to Observe Early Photons from Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Jeong, S.; Panasyuk, M. I.; Reglero, V.; Connell, P.; Kim, M. B.; Lee, J.; Rodrigo, J. M.; Ripa, J.; Eyles, C.; Lim, H.; Gaikov, G.; Jeong, H.; Leonov, V.; Chen, P.; Castro-Tirado, A. J.; Nam, J. W.; Svertilov, S.; Yashin, I.; Garipov, G.; Huang, M.-H. A.; Huang, J.-J.; Kim, J. E.; Liu, T.-C.; Petrov, V.; Bogomolov, V.; Budtz-Jørgensen, C.; Brandt, S.; Park, I. H.

2018-02-01

The Ultra-Fast Flash Observatory (UFFO) Burst Alert and Trigger Telescope (UBAT) has been designed and built for the localization of transient X-ray sources such as Gamma Ray Bursts (GRBs). As one of main instruments in the UFFO payload onboard the Lomonosov satellite (hereafter UFFO/ Lomonosov), the UBAT's roles are to monitor the X-ray sky, to rapidly locate and track transient sources, and to trigger the slewing of a UV/optical telescope, namely Slewing Mirror Telescope (SMT). The SMT, a pioneering application of rapid slewing mirror technology has a line of sight parallel to the UBAT, allowing us to measure the early UV/optical GRB counterpart and study the extremely early moments of GRB evolution. To detect X-rays, the UBAT utilizes a 191.1 cm2 scintillation detector composed of Yttrium Oxyorthosilicate (YSO) crystals, Multi-Anode Photomultiplier Tubes (MAPMTs), and associated electronics. To estimate a direction vector of a GRB source in its field of view, it employs the well-known coded aperture mask technique. All functions are written for implementation on a field programmable gate array to enable fast triggering and to run the device's imaging algorithms. The UFFO/ Lomonosov satellite was launched on April 28, 2016, and is now collecting GRB observation data. In this study, we describe the UBAT's design, fabrication, integration, and performance as a GRB X-ray trigger and localization telescope, both on the ground and in space.

Caenorhabditis elegans fibroblast growth factor receptor signaling can occur independently of the multi-substrate adaptor FRS2.

PubMed

Lo, Te-Wen; Bennett, Daniel C; Goodman, S Jay; Stern, Michael J

2010-06-01

The components of receptor tyrosine kinase signaling complexes help to define the specificity of the effects of their activation. The Caenorhabditis elegans fibroblast growth factor receptor (FGFR), EGL-15, regulates a number of processes, including sex myoblast (SM) migration guidance and fluid homeostasis, both of which require a Grb2/Sos/Ras cassette of signaling components. Here we show that SEM-5/Grb2 can bind directly to EGL-15 to mediate SM chemoattraction. A yeast two-hybrid screen identified SEM-5 as able to interact with the carboxy-terminal domain (CTD) of EGL-15, a domain that is specifically required for SM chemoattraction. This interaction requires the SEM-5 SH2-binding motifs present in the CTD (Y(1009) and Y(1087)), and these sites are required for the CTD role of EGL-15 in SM chemoattraction. SEM-5, but not the SEM-5 binding sites located in the CTD, is required for the fluid homeostasis function of EGL-15, indicating that SEM-5 can link to EGL-15 through an alternative mechanism. The multi-substrate adaptor protein FRS2 serves to link vertebrate FGFRs to Grb2. In C. elegans, an FRS2-like gene, rog-1, functions upstream of a Ras/MAPK pathway for oocyte maturation but is not required for EGL-15 function. Thus, unlike the vertebrate FGFRs, which require the multi-substrate adaptor FRS2 to recruit Grb2, EGL-15 can recruit SEM-5/Grb2 directly.

Groundwater Arsenic Contamination in the Ganga River Basin: A Future Health Danger

PubMed Central

Chakraborti, Dipankar; Rahman, Mohammad Mahmudur; Dutta, Rathindra Nath; Mukherjee, Subhas Chandra; Pati, Shyamapada; Kar, Probir Bijoy

2018-01-01

This study highlights the severity of arsenic contamination in the Ganga River basin (GRB), which encompasses significant geographic portions of India, Bangladesh, Nepal, and Tibet. The entire GRB experiences elevated levels of arsenic in the groundwater (up to 4730 µg/L), irrigation water (~1000 µg/L), and in food materials (up to 3947 µg/kg), all exceeding the World Health Organization’s standards for drinking water, the United Nations Food and Agricultural Organization’s standard for irrigation water (100 µg/L), and the Chinese Ministry of Health’s standard for food in South Asia (0.15 mg/kg), respectively. Several individuals demonstrated dermal, neurological, reproductive, cognitive, and cancerous effects; many children have been diagnosed with a range of arsenicosis symptoms, and numerous arsenic-induced deaths of youthful victims are reported in the GRB. Victims of arsenic exposure face critical social challenges in the form of social isolation and hatred by their respective communities. Reluctance to establish arsenic standards and unsustainable arsenic mitigation programs have aggravated the arsenic calamity in the GRB and put millions of lives in danger. This alarming situation resembles a ticking time bomb. We feel that after 29 years of arsenic research in the GRB, we have seen the tip of the iceberg with respect to the actual magnitude of the catastrophe; thus, a reduced arsenic standard for drinking water, testing all available drinking water sources, and sustainable and cost-effective arsenic mitigation programs that include the participation of the people are urgently needed. PMID:29360747

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.

PubMed

Han, Jie; Goldstein, Leslie A; Gastman, Brian R; Froelich, Christopher J; Yin, Xiao-Ming; Rabinowich, Hannah

2004-05-21

Recent studies have suggested that in the absence of Bid, granzyme B (GrB) can utilize an unknown alternative pathway to mediate mitochondrial apoptotic events. The current study has elucidated just such a pathway for GrB-mediated mitochondrial apoptotic alterations. Two Bcl-2 family members have been identified as interactive players in this newly discovered mitochondrial response to GrB: the pro-survival protein Mcl-1L and the pro-apoptotic protein, Bim. Expression of Mcl-1L, which localizes mainly to the outer mitochondrial membrane, decreases significantly in cells subjected to CTL-free cytotoxicity mediated by a combination of GrB and replication-deficient adenovirus. The data suggest that Mcl-1L is a substrate for GrB and for caspase-3, but the two enzymes appear to target different cleavage sites. The cleavage pattern of endogenous Mcl-1L resembles that of in vitro translated Mcl-1L subjected to similar proteolytic activity. Co-immunoprecipitation experiments performed with endogenous as well as with in vitro translated proteins suggest that Mcl-1L is a high affinity binding partner of the three isoforms of Bim (extra-long, long, and short). Bim, a BH3-only protein, is capable of mediating the release of mitochondrial cytochrome c, and this activity is inhibited by the presence of exogenous Mcl-1L. The findings presented herein imply that Mcl-1L degradation by either GrB or caspase-3 interferes with Bim sequestration by Mcl-1L.

Groundwater Arsenic Contamination in the Ganga River Basin: A Future Health Danger.

PubMed

Chakraborti, Dipankar; Singh, Sushant K; Rahman, Mohammad Mahmudur; Dutta, Rathindra Nath; Mukherjee, Subhas Chandra; Pati, Shyamapada; Kar, Probir Bijoy

2018-01-23

This study highlights the severity of arsenic contamination in the Ganga River basin (GRB), which encompasses significant geographic portions of India, Bangladesh, Nepal, and Tibet. The entire GRB experiences elevated levels of arsenic in the groundwater (up to 4730 µg/L), irrigation water (~1000 µg/L), and in food materials (up to 3947 µg/kg), all exceeding the World Health Organization's standards for drinking water, the United Nations Food and Agricultural Organization's standard for irrigation water (100 µg/L), and the Chinese Ministry of Health's standard for food in South Asia (0.15 mg/kg), respectively. Several individuals demonstrated dermal, neurological, reproductive, cognitive, and cancerous effects; many children have been diagnosed with a range of arsenicosis symptoms, and numerous arsenic-induced deaths of youthful victims are reported in the GRB. Victims of arsenic exposure face critical social challenges in the form of social isolation and hatred by their respective communities. Reluctance to establish arsenic standards and unsustainable arsenic mitigation programs have aggravated the arsenic calamity in the GRB and put millions of lives in danger. This alarming situation resembles a ticking time bomb. We feel that after 29 years of arsenic research in the GRB, we have seen the tip of the iceberg with respect to the actual magnitude of the catastrophe; thus, a reduced arsenic standard for drinking water, testing all available drinking water sources, and sustainable and cost-effective arsenic mitigation programs that include the participation of the people are urgently needed.

Novel adapter proteins that link the human GM-CSF receptor to the phosphatidylino-sitol 3-kinase and Shc/Grb2/ras signaling pathways.

PubMed

Jücker, M; Feldman, R A

1996-01-01

We have used a human GM-CSF-dependent hematopoietic cell line that responds to physiological concentrations of hGM-CSF to analyze a set of signaling events that occur in normal myelopoiesis and whose deregulation may lead to leukemogenesis. Stimulation of these cells with hGM-CSF induced the assembly of multimeric complexes that contained known and novel phosphotyrosyl proteins. One of the new proteins was a major phosphotyrosyl substrate of 76-85 kDa (p80) that was directly associated with the p85 subunit of phosphatidylinositol (PI) 3-kinase through the SH2 domains of p85. p80 also associated with the beta subunit of the activated hGM-CSF receptor, and assembly of this complex correlated with activation of PI 3-kinase. A second phosphotyrosyl protein we identified, p140, associated with the Shc and Grb2 adapter proteins by direct binding to a novel phosphotyrosine-interacting domain located at the N-terminus of Shc. and to the SH3 domains of Grb2, respectively. The Shc/p140/Grb2 complex was found to be constitutively activated in acute myeloid leukemia cells, indicating that activation of this pathway may be a necessary step in the development of some leukemias. The p80/p85/PI 3-kinase and the Shc/Grb2/p140 complexes were tightly associated with Src family kinases, which were prime candidates for phosphorylation of Shc, p80, p140 and other phosphotyrosyl substrates present in these complexes. Our studies suggest that p80 and p140 may link the hGM-CSF receptor to the PI 3-kinase and Shc/Grb2/ras signaling pathways, respectively, and that abnormal activation of hGM-CSF-dependent targets may play a role in leukemogenesis.

iPTF17cw: An Engine-driven Supernova Candidate Discovered Independent of a Gamma-Ray Trigger

NASA Astrophysics Data System (ADS)

Corsi, A.; Cenko, S. B.; Kasliwal, M. M.; Quimby, R.; Kulkarni, S. R.; Frail, D. A.; Goldstein, A. M.; Blagorodnova, N.; Connaughton, V.; Perley, D. A.; Singer, L. P.; Copperwheat, C. M.; Fremling, C.; Kupfer, T.; Piascik, A. S.; Steele, I. A.; Taddia, F.; Vedantham, H.; Kutyrev, A.; Palliyaguru, N. T.; Roberts, O.; Sollerman, J.; Troja, E.; Veilleux, S.

2017-09-01

We present the discovery, classification, and radio-to-X-ray follow-up observations of iPTF17cw, a broad-lined (BL) type Ic supernova (SN) discovered by the intermediate Palomar Transient Factory (iPTF). Although it is unrelated to the gravitational wave trigger, this SN was discovered as a happy by-product of the extensive observational campaign dedicated to the follow-up of Advanced LIGO event GW 170104. The spectroscopic properties and inferred peak bolometric luminosity of iPTF17cw are most similar to the gamma-ray-burst (GRB)-associated SN, SN 1998bw, while the shape of the r-band light curve is most similar to that of the relativistic SN, SN 2009bb. Karl G. Jansky Very Large Array (VLA) observations of the iPTF17cw field reveal a radio counterpart ≈10 times less luminous than SN 1998bw, and with a peak radio luminosity comparable to that of SN 2006aj/GRB 060218 and SN 2010bh/GRB 100316D. Our radio observations of iPTF17cw imply a relativistically expanding outflow. However, further late-time observations with the VLA in its most extended configuration are needed to confirm fading of the iPTF17cw radio counterpart at all frequencies. X-ray observations carried out with Chandra reveal the presence of an X-ray counterpart with a luminosity similar to that of SN 2010bh/GRB 100316D. Searching the Fermi catalog for possible γ-rays reveals that GRB 161228B is spatially and temporally compatible with iPTF17cw. The similarity to SN 1998bw and SN 2009bb, the radio and X-ray detections, and the potential association with GRB 161228B all point to iPTF17cw being a new candidate member of the rare sample of optically discovered engine-driven BL-Ic SNe associated with relativistic ejecta.

iPTF17cw: An Engine-driven Supernova Candidate Discovered Independent of a Gamma-Ray Trigger

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corsi, A.; Palliyaguru, N. T.; Cenko, S. B.

We present the discovery, classification, and radio-to-X-ray follow-up observations of iPTF17cw, a broad-lined (BL) type Ic supernova (SN) discovered by the intermediate Palomar Transient Factory (iPTF). Although it is unrelated to the gravitational wave trigger, this SN was discovered as a happy by-product of the extensive observational campaign dedicated to the follow-up of Advanced LIGO event GW 170104. The spectroscopic properties and inferred peak bolometric luminosity of iPTF17cw are most similar to the gamma-ray-burst (GRB)-associated SN, SN 1998bw, while the shape of the r -band light curve is most similar to that of the relativistic SN, SN 2009bb. Karl G.more » Jansky Very Large Array (VLA) observations of the iPTF17cw field reveal a radio counterpart ≈10 times less luminous than SN 1998bw, and with a peak radio luminosity comparable to that of SN 2006aj/GRB 060218 and SN 2010bh/GRB 100316D. Our radio observations of iPTF17cw imply a relativistically expanding outflow. However, further late-time observations with the VLA in its most extended configuration are needed to confirm fading of the iPTF17cw radio counterpart at all frequencies. X-ray observations carried out with Chandra reveal the presence of an X-ray counterpart with a luminosity similar to that of SN 2010bh/GRB 100316D. Searching the Fermi catalog for possible γ -rays reveals that GRB 161228B is spatially and temporally compatible with iPTF17cw. The similarity to SN 1998bw and SN 2009bb, the radio and X-ray detections, and the potential association with GRB 161228B all point to iPTF17cw being a new candidate member of the rare sample of optically discovered engine-driven BL-Ic SNe associated with relativistic ejecta.« less

Granzyme B mediated function of Parvovirus B19-specific CD4+ T cells

PubMed Central

Kumar, Arun; Perdomo, Maria F; Kantele, Anu; Hedman, Lea; Hedman, Klaus; Franssila, Rauli

2015-01-01

A novel conception of CD4+ T cells with cytolytic potential (CD4+ CTL) is emerging. These cells appear to have a part in controlling malignancies and chronic infections. Human parvovirus B19 can cause a persistent infection, yet no data exist on the presence of B19-specific CD4+ CTLs. Such cells could have a role in the pathogenesis of some autoimmune disorders reported to be associated with B19. We explored the cytolytic potential of human parvovirus B19-specific T cells by stimulating peripheral blood mononuclear cell (PBMC) with recombinant B19-VP2 virus-like particles. The cytolytic potential was determined by enzyme immunoassay-based quantitation of granzyme B (GrB) and perforin from the tissue culture supernatants, by intracellular cytokine staining (ICS) and by detecting direct cytotoxicity. GrB and perforin responses with the B19 antigen were readily detectable in B19-seropositive individuals. T-cell depletion, HLA blocking and ICS experiments showed GrB and perforin to be secreted by CD4+ T cells. CD4+ T cells with strong GrB responses were found to exhibit direct cytotoxicity. As anticipated, ICS of B19-specific CD4+ T cells showed expected co-expression of GrB, perforin and interferon gamma (IFN-γ). Unexpectedly, also a strong co-expression of GrB and interleukin 17 (IL-17) was detected. These cells expressed natural killer (NK) cell surface marker CD56, together with the CD4 surface marker. To our knowledge, this is the first report on virus-specific CD4+ CTLs co-expressing CD56 antigen. Our results suggest a role for CD4+ CTL in B19 immunity. Such cells could function within both immune regulation and triggering of autoimmune phenomena such as systemic lupus erythematosus (SLE) or rheumatoid arthritis. PMID:26246896

Deep Photometry of GRB 041006 Afterglow: Hypernova Bump at Redshift z = 0.716

NASA Astrophysics Data System (ADS)

Stanek, K. Z.; Garnavich, P. M.; Nutzman, P. A.; Hartman, J. D.; Garg, A.; Adelberger, K.; Berlind, P.; Bonanos, A. Z.; Calkins, M. L.; Challis, P.; Gaudi, B. S.; Holman, M. J.; Kirshner, R. P.; McLeod, B. A.; Osip, D.; Pimenova, T.; Reiprich, T. H.; Romanishin, W.; Spahr, T.; Tegler, S. C.; Zhao, X.

2005-06-01

We present deep optical photometry of the afterglow of gamma-ray burst (GRB) 041006 and its associated hypernova obtained over 65 days after detection (55 R-band epochs on 10 different nights). Our early data (t<4 days) joined with published GCN data indicate a steepening decay, approaching Fν~t-0.6 at early times (t<<1 day) and Fν~t-1.3 at late times. The break at tb=0.16+/-0.04 days is the earliest reported jet break among all GRB afterglows. During our first night, we obtained 39 exposures spanning 2.15 hr from 0.62 to 0.71 days after the burst that reveal a smooth afterglow, with an rms deviation of 0.024 mag from the local power-law fit, consistent with photometric errors. After t~4 days, the decay slows considerably, and the light curve remains approximately flat at R~24 mag for a month before decaying by another magnitude to reach R~25 mag 2 months after the burst. This ``bump'' is well fit by a k-corrected light curve of supernova SN 1998bw, but only if stretched by a factor of 1.38 in time. In comparison with the other GRB-related SN bumps, GRB 041006 stakes out new parameter space for GRBs/SNe, with a very bright and significantly stretched late-time SN light curve. Within a small sample of fairly well observed GRB/SN bumps, we see a hint of a possible correlation between their peak luminosity and their ``stretch factor,'' broadly similar to the well-studied Phillips relation for the Type Ia supernovae. Based on data from the MMT Observatory 6.5 m telescope, the 1.8 m Vatican Advanced Technology Telescope, the Magellan 6.5 m Baade and Clay telescopes, and the Keck II 10 m telescope.

OGLE-2013-BLG-0132Lb and OGLE-2013-BLG-1721Lb: Two Saturn-mass Planets Discovered around M-dwarfs

NASA Astrophysics Data System (ADS)

Mróz, Przemek; Udalski, A.; Bond, I. A.; Skowron, J.; Sumi, T.; Han, C.; Szymański, M. K.; Soszyński, I.; Poleski, R.; Pietrukowicz, P.; Kozłowski, S.; Wyrzykowski, Ł.; Ulaczyk, K.; OGLE Collaboration; Abe, F.; Asakura, Y.; Barry, R. K.; Bennett, D. P.; Bhattacharya, A.; Donachie, M.; Evans, P.; Fukui, A.; Hirao, Y.; Itow, Y.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Ranc, C.; Rattenbury, N. J.; Saito, To.; Sharan, A.; Sullivan, D. J.; Suzuki, D.; Tristram, P. J.; Yamada, T.; Yamada, T.; Yonehara, A.; The MOA Collaboration

2017-11-01

We present the discovery of two planetary systems consisting of a Saturn-mass planet orbiting an M-dwarf, which were detected in faint microlensing events OGLE-2013-BLG-0132 and OGLE-2013-BLG-1721. The planetary anomalies were covered with high cadence by Optical Gravitational Lensing Experiment (OGLE) and Microlensing Observations in Astrophysics (MOA) photometric surveys. The light curve modeling indicates that the planet-to-host mass ratios are (5.15+/- 0.28)× {10}-4 and (13.18+/- 0.72)× {10}-4, respectively. Both events were too short and too faint to measure a reliable parallax signal and hence the lens mass. We therefore used a Bayesian analysis to estimate the masses of both planets: {0.29}-0.13+0.16 {M}{Jup} (OGLE-2013-BLG-0132Lb) and {0.64}-0.31+0.35 {M}{Jup} (OGLE-2013-BLG-1721Lb). Thanks to a high relative proper motion, OGLE-2013-BLG-0132 is a promising candidate for the high-resolution imaging follow-up. Both planets belong to an increasing sample of sub-Jupiter-mass planets orbiting M-dwarfs beyond the snow line.

The Star, the Dwarf and the Planet

NASA Astrophysics Data System (ADS)

2006-10-01

Astronomers have detected a new faint companion to the star HD 3651, already known to host a planet. This companion, a brown dwarf, is the faintest known companion of an exoplanet host star imaged directly and one of the faintest T dwarfs detected in the Solar neighbourhood so far. The detection yields important information on the conditions under which planets form. "Such a system is an interesting example that might prove that planets and brown dwarfs can form around the same star", said Markus Mugrauer, lead author of the paper presenting the discovery. ESO PR Photo 39a/06 ESO PR Photo 39a/06 The Companion to HD 3651 HD 3651 is a star slightly less massive than the Sun, located 36 light-years away in the constellation Pisces (the "Fish"). For several years, it has been known to harbour a planet less massive than Saturn, sitting closer to its parent star than Mercury is from the Sun: the planet accomplishes a full orbit in 62 days. Mugrauer and his colleagues first spotted the faint companion in 2003 on images from the 3.8-m United Kingdom Infrared Telescope (UKIRT) in Hawaii. Observations in 2004 and 2006 using ESO's 3.6 m New Technology Telescope (NTT) at La Silla provided the crucial confirmation that the speck of light is not a spurious background star, but indeed a true companion. The newly found companion, HD 3651B, is 16 times further away from HD 3651 than Neptune is from the Sun. HD 3651B is the dimmest directly imaged companion of an exoplanet host star. Furthermore, as it is not detected on the photographic plates of the Palomar All Sky Survey, the companion must be even fainter in the visible spectral range than in the infrared, meaning it is a very cool low-mass sub-stellar object. Comparing its characteristics with theoretical models, the astronomers infer that the object has a mass between 20 and 60 Jupiter masses, and a temperature between 500 and 600 degrees Celsius. It is thus ten times colder and 300 000 less luminous than the Sun. These properties place it in the category of cool T-type brown dwarfs. ESO PR Photo 38b/06 ESO PR Photo 39b/06 The Relative Position of the Companion to HD 3651 "Due to their faintness even in the infrared, these cool T dwarfs are very difficult to find", said Mugrauer. "Only two other brown dwarfs with similar brightness are presently known. Their study will provide important insights into the atmospheric properties of cool sub-stellar objects." More than 170 stars are currently known to host exoplanets. In some cases, these stars were also found to have one or several stellar companions, showing that planet formation can also take place in a dynamically more complex environment than our own Solar System where planet formation occurred around an isolated single star. In 2001, Mugrauer and his colleagues started an observational programme to find out whether exoplanet host stars are single or married. In this programme, known exoplanet host stars are systematically imaged at two different epochs, at least several months apart. True companions can be distinguished from coincidental background objects as only they move together with the stars over time. With this effective search strategy several new companions of exoplanet host stars have been detected. Most of the detected companions are low-mass stars in the same evolutionary state as the Sun. In two cases, however, the astronomers found the companions to be white dwarfs, that is, stars at the end of their life. These intriguing systems bear evidence that planets can even survive the troubled last moments in the life of a nearby star. The planet host star HD 3651 is thus surrounded by two sub-stellar objects. The planet, HD 3651b, is very close, while the newly found brown dwarf companion revolves around the star 1500 times farther away than the planet. This system is the first imaged example that planets and brown dwarfs can form around the same star.

AzTEC/ASTE 1.1 mm Deep Surveys: Number Counts and Clustering of Millimeter-bright Galaxies

NASA Astrophysics Data System (ADS)

Hatsukade, B.; Kohno, K.; Aretxaga, I.; Austermann, J. E.; Ezawa, H.; Hughes, D. H.; Ikarashi, S.; Iono, D.; Kawabe, R.; Matsuo, H.; Matsuura, S.; Nakanishi, K.; Oshima, T.; Perera, T.; Scott, K. S.; Shirahata, M.; Takeuchi, T. T.; Tamura, Y.; Tanaka, K.; Tosaki, T.; Wilson, G. W.; Yun, M. S.

2010-10-01

We present number counts and clustering properties of millimeter-bright galaxies uncovered by the AzTEC camera mounted on the Atacama Submillimeter Telescope Experiment (ASTE). We surveyed the AKARI Deep Field South (ADF-S), the Subaru/XMM Newton Deep Field (SXDF), and the SSA22 fields with an area of ~0.25 deg2 each with an rms noise level of ~0.4-1.0 mJy. We constructed differential and cumulative number counts, which provide currently the tightest constraints on the faint end. The integration of the best-fit number counts in the ADF-S find that the contribution of 1.1 mm sources with fluxes >=1 mJy to the cosmic infrared background (CIB) at 1.1 mm is 12-16%, suggesting that the large fraction of the CIB originates from faint sources of which the number counts are not yet constrained. We estimate the cosmic star-formation rate density contributed by 1.1 mm sources with >=1 mJy using the best-fit number counts in the ADF-S and find that it is lower by about a factor of 5-10 compared to those derived from UV/optically-selected galaxies at z~2-3. The average mass of dark halos hosting bright 1.1 mm sources was calculated to be 1013-1014 Msolar. Comparison of correlation lengths of 1.1 mm sources with other populations and with a bias evolution model suggests that dark halos hosting bright 1.1 mm sources evolve into systems of clusters at present universe and the 1.1 mm sources residing the dark halos evolve into massive elliptical galaxies located in the center of clusters.

Sweating the small stuff: simulating dwarf galaxies, ultra-faint dwarf galaxies, and their own tiny satellites

NASA Astrophysics Data System (ADS)

Wheeler, Coral Rose

2016-06-01

The high dark matter content and the shallow potential wells of low mass galaxies (10^3 Msun < Mstar < 10^9.5 Msun) make them excellent testbeds for differing theories of galaxy formation. Additionally, the recent up-tick in the number and detail of Local Group dwarf galaxy observations provides a rich dataset for comparison to simulations that attempt to answer important questions in near field cosmology: why are there so few observed dwarfs compared to the number predicted by simulations? What shuts down star formation in ultra-faint galaxies? Why do dwarfs have inverted age gradients and what does it take to convert a dwarf irregular (dIrrs) into a dwarf spheroidal (dSph) galaxy?We to attempt to answer these questions by running ultra-high resolution cosmological FIRE simulations of isolated dwarf galaxies. We predict that many ultra-faint dwarfs should exist as satellites of more massive isolated Local Group dwarfs. The ultra-faints (Mstar < 10^4 Msun) formed in these simulations have uniformly ancient stellar populations (> 10 Gyr), having had their star formation shut down by reionization. Additionally, we show that the kinematics and ellipticities of isolated simulated dwarf centrals are consistent with observed dSphs satellites without the need for harassment from a massive host. We further show that most (but not all) observed *isolated* dIrrs in the Local Volume also have dispersion-supported stellar populations, contradicting the previous view that these objects are rotating. Finally, we investigate the stellar age gradients in dwarfs — showing that early mergers and strong feedback can create an inverted gradient, with the older stars occupying larger galactocentric radii.These results offer an interesting direction in testing models that attempt to solve dark matter problems via explosive feedback episodes. Can the same models that create large cores in simulated dwarfs preserve the mild stellar rotation that is seen in a minority of isolated dIrrs? Can the bursty star formation that created a dark matter core also match observed stellar gradients in low mass galaxies? Comparisons between our simulations and observed dwarfs should provide an important benchmark for this question going forward.

Concluding Remarks: The Current Status and Future Prospects for GRB Astronomy

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2009-01-01

We are in a remarkable period of discovery in GRB astronomy. The current satellites including Swift, Fermi. AGILE and INTEGRAL are detecting and observing bursts of all varieties. Increasing capabilities for follow-up observations on the ground and in space are leading to rapid and deep coverage across the electromagnetic spectrum, The future will see continued operation of the current experiments and with future missions like SVOM plus possible rni_Ssions like JANUS and EXIST. An exciting expansion of capabilities is occurring in areas of gravitational waves and neutrinos that could open new windows on the GRB phenomenon. Increased IR capabilities on the ground and with missions like JWST will enable further exploration of high redshift bursts. The future is bright.

Gamma-ray bursts at high and very high energies

NASA Astrophysics Data System (ADS)

Piron, Frédéric

2016-06-01

Gamma-Ray Bursts (GRBs) are extra-galactic and extremely energetic transient emissions of gamma rays, which are thought to be associated with the death of massive stars or the merger of compact objects in binary systems. Their huge luminosities involve the presence of a newborn stellar-mass black hole emitting a relativistic collimated outflow, which accelerates particles and produces non-thermal emissions from the radio domain to the highest energies. In this article, I review recent progresses in the understanding of GRB jet physics above 100 MeV, based on Fermi observations of bright GRBs. I discuss the physical implications of these observations and their impact on GRB modeling, and I present some prospects for GRB observation at very high energies in the near future.

Fermi observations of high-energy gamma-ray emission from GRB 080916C.

PubMed

Abdo, A A; Ackermann, M; Arimoto, M; Asano, K; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Band, D L; Barbiellini, G; Baring, M G; Bastieri, D; Battelino, M; Baughman, B M; Bechtol, K; Bellardi, F; Bellazzini, R; Berenji, B; Bhat, P N; Bissaldi, E; Blandford, R D; Bloom, E D; Bogaert, G; Bogart, J R; Bonamente, E; Bonnell, J; Borgland, A W; Bouvier, A; Bregeon, J; Brez, A; Briggs, M S; Brigida, M; Bruel, P; Burnett, T H; Burrows, D; Busetto, G; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Ceccanti, M; Cecchi, C; Celotti, A; Charles, E; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Cominsky, L R; Connaughton, V; Conrad, J; Costamante, L; Cutini, S; Deklotz, M; Dermer, C D; de Angelis, A; de Palma, F; Digel, S W; Dingus, B L; do Couto E Silva, E; Drell, P S; Dubois, R; Dumora, D; Edmonds, Y; Evans, P A; Fabiani, D; Farnier, C; Favuzzi, C; Finke, J; Fishman, G; Focke, W B; Frailis, M; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giebels, B; Giglietto, N; Giommi, P; Giordano, F; Glanzman, T; Godfrey, G; Goldstein, A; Granot, J; Greiner, J; Grenier, I A; Grondin, M-H; Grove, J E; Guillemot, L; Guiriec, S; Haller, G; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hernando Morat, J A; Hoover, A; Hughes, R E; Jóhannesson, G; Johnson, A S; Johnson, R P; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kavelaars, A; Kawai, N; Kelly, H; Kennea, J; Kerr, M; Kippen, R M; Knödlseder, J; Kocevski, D; Kocian, M L; Komin, N; Kouveliotou, C; Kuehn, F; Kuss, M; Lande, J; Landriu, D; Larsson, S; Latronico, L; Lavalley, C; Lee, B; Lee, S-H; Lemoine-Goumard, M; Lichti, G G; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Marangelli, B; Mazziotta, M N; McBreen, S; McEnery, J E; McGlynn, S; Meegan, C; Mészáros, P; Meurer, C; Michelson, P F; Minuti, M; Mirizzi, N; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Moretti, E; Morselli, A; Moskalenko, I V; Murgia, S; Nakamori, T; Nelson, D; Nolan, P L; Norris, J P; Nuss, E; Ohno, M; Ohsugi, T; Okumura, A; Omodei, N; Orlando, E; Ormes, J F; Ozaki, M; Paciesas, W S; Paneque, D; Panetta, J H; Parent, D; Pelassa, V; Pepe, M; Perri, M; Pesce-Rollins, M; Petrosian, V; Pinchera, M; Piron, F; Porter, T A; Preece, R; Rainò, S; Ramirez-Ruiz, E; Rando, R; Rapposelli, E; Razzano, M; Razzaque, S; Rea, N; Reimer, A; Reimer, O; Reposeur, T; Reyes, L C; Ritz, S; Rochester, L S; Rodriguez, A Y; Roth, M; Ryde, F; Sadrozinski, H F-W; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Schalk, T L; Segal, K N; Sgrò, C; Shimokawabe, T; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Stamatikos, M; Starck, J-L; Stecker, F W; Steinle, H; Stephens, T E; Strickman, M S; Suson, D J; Tagliaferri, G; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Tenze, A; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Turri, M; Tuvi, S; Usher, T L; van der Horst, A J; Vigiani, L; Vilchez, N; Vitale, V; von Kienlin, A; Waite, A P; Williams, D A; Wilson-Hodge, C; Winer, B L; Wood, K S; Wu, X F; Yamazaki, R; Ylinen, T; Ziegler, M

2009-03-27

Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. The known distance of the burst enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.

The accelerated build-up of the red sequence in high-redshift galaxy clusters

NASA Astrophysics Data System (ADS)

Cerulo, P.; Couch, W. J.; Lidman, C.; Demarco, R.; Huertas-Company, M.; Mei, S.; Sánchez-Janssen, R.; Barrientos, L. F.; Muñoz, R. P.

2016-04-01

We analyse the evolution of the red sequence in a sample of galaxy clusters at redshifts 0.8 < z < 1.5 taken from the HAWK-I Cluster Survey (HCS). The comparison with the low-redshift (0.04 < z < 0.08) sample of the WIde-field Nearby Galaxy-cluster Survey (WINGS) and other literature results shows that the slope and intrinsic scatter of the cluster red sequence have undergone little evolution since z = 1.5. We find that the luminous-to-faint ratio and the slope of the faint end of the luminosity distribution of the HCS red sequence are consistent with those measured in WINGS, implying that there is no deficit of red galaxies at magnitudes fainter than M_V^{ast } at high redshifts. We find that the most massive HCS clusters host a population of bright red sequence galaxies at MV < -22.0 mag, which are not observed in low-mass clusters. Interestingly, we also note the presence of a population of very bright (MV < -23.0 mag) and massive (log (M*/M⊙) > 11.5) red sequence galaxies in the WINGS clusters, which do not include only the brightest cluster galaxies and which are not present in the HCS clusters, suggesting that they formed at epochs later than z = 0.8. The comparison with the luminosity distribution of a sample of passive red sequence galaxies drawn from the COSMOS/UltraVISTA field in the photometric redshift range 0.8 < zphot < 1.5 shows that the red sequence in clusters is more developed at the faint end, suggesting that halo mass plays an important role in setting the time-scales for the build-up of the red sequence.

Broad-line Type Ic supernova SN 2014ad

NASA Astrophysics Data System (ADS)

Sahu, D. K.; Anupama, G. C.; Chakradhari, N. K.; Srivastav, S.; Tanaka, Masaomi; Maeda, Keiichi; Nomoto, Ken'ichi

2018-04-01

We present optical and ultraviolet photometry and low-resolution optical spectroscopy of the broad-line Type Ic supernova SN 2014ad in the galaxy PGC 37625 (Mrk 1309), covering the evolution of the supernova during -5 to +87 d with respect to the date of maximum in the B band. A late-phase spectrum obtained at +340 d is also presented. With an absolute V-band magnitude at peak of MV = -18.86 ± 0.23 mag, SN 2014ad is fainter than supernovae associated with gamma ray bursts (GRBs), and brighter than most of the normal and broad-line Type Ic supernovae without an associated GRB. The spectral evolution indicates that the expansion velocity of the ejecta, as measured using the Si II line, is as high as ˜33 500 km s-1 around maximum, while during the post-maximum phase it settles at ˜15 000 km s-1. The expansion velocity of SN 2014ad is higher than that of all other well-observed broad-line Type Ic supernovae except for the GRB-associated SN 2010bh. The explosion parameters, determined by applying Arnett's analytical light-curve model to the observed bolometric light-curve, indicate that it was an energetic explosion with a kinetic energy of ˜(1 ± 0.3) × 1052 erg and a total ejected mass of ˜(3.3 ± 0.8) M⊙, and that ˜0.24 M⊙ of 56Ni was synthesized in the explosion. The metallicity of the host galaxy near the supernova region is estimated to be ˜0.5 Z⊙.

Demise of faint satellites around isolated early-type galaxies

NASA Astrophysics Data System (ADS)

Park, Changbom; Hwang, Ho Seong; Park, Hyunbae; Lee, Jong Chul

2018-02-01

The hierarchical galaxy formation scenario in the Cold Dark Matter cosmology with a non-vanishing cosmological constant Λ and geometrically flat space (ΛCDM) has been very successful in explaining the large-scale distribution of galaxies. However, there have been claims that ΛCDM over-predicts the number of satellite galaxies associated with massive galaxies compared with observations—the missing satellite galaxy problem1-3. Isolated groups of galaxies hosted by passively evolving massive early-type galaxies are ideal laboratories for identifying the missing physics in the current theory4-11. Here, we report—based on a deep spectroscopic survey—that isolated massive and passive early-type galaxies without any signs of recent wet mergers or accretion episodes have almost no satellite galaxies fainter than the r-band absolute magnitude of about Mr = -14. If only early-type satellites are used, the cutoff is at the somewhat brighter magnitude of about Mr = -15. Such a cutoff has not been found in other nearby satellite galaxy systems hosted by late-type galaxies or those with merger features. Various physical properties of satellites depend strongly on the host-centric distance. Our observations indicate that the satellite galaxy luminosity function is largely determined by the interaction of satellites with the environment provided by their host.

Chandra Contributes to ESA's Integral Detection of Closest Gamma-Ray Burst

NASA Astrophysics Data System (ADS)

2004-08-01

A gamma-ray burst detected by ESA's Integral gamma-ray observatory on 3 December 2003 has been thoroughly studied for months by an armada of space and ground-based observatories. Astronomers have now concluded that this event, called GRB 031203, is the closest cosmic gamma-ray burst on record, and also the faintest. This also suggests that an entire population of sub-energetic gamma-ray bursts has so far gone unnoticed. Cosmic gamma-ray bursts (GRBs) are flashes of gamma rays that can last from less than a second to a few minutes and occur at random positions in the sky. A large fraction of them is thought to result when a black hole is created from a dying star in a distant galaxy. Astronomers believe that a hot disc surrounding the black hole, made of gas and matter falling onto it, somehow emits an energetic beam parallel to the axis of rotation. According to the simplest picture, all GRBs should emit similar amounts of gamma-ray energy. The fraction of it detected at Earth should then depend on the 'width' (opening angle) and orientation of the beam as well as on the distance. The energy received should be larger when the beam is narrow or points towards us and smaller when the beam is broad or points away from us. New data collected with ESA's high energy observatories, Integral and XMM-Newton, now show that this picture is not so clear-cut and that the amount of energy emitted by GRBs can vary significantly. "The idea that all GRBs spit out the same amount of gamma rays, or that they are 'standard candles' as we call them, is simply ruled out by the new data," said Dr Sergey Sazonov, from the Space Research Institute of the Russian Academy of Sciences, Moscow (Russia) and the Max-Planck Institute for Astrophysics, Garching near Munich (Germany). Sazonov and an international team of researchers studied the GRB detected by Integral on 3 December 2003 and given the code-name of GRB 031203. Within a record 18 seconds of the burst, the Integral Burst Alert System had pinpointed the approximate position of GRB 031203 in the sky and sent the information to a network of observatories around the world. A few hours later one of them, ESA's XMM-Newton, determined a much more precise position for GRB 031203 and detected a rapidly fading X-ray source, which was subsequently seen by radio and optical telescopes on the ground. This wealth of data allowed astronomers to determine that GRB 031203 went off in a galaxy less than 1300 million light years away, making it the closest GRB ever observed. Even so, the way in which GRB 031203 dimmed with time and the distribution of its energy were not different from those of distant GRBs. Then, scientists started to realise that the concept of the 'standard candle' may not hold. "Being so close should make GRB 031203 appear very bright, but the amount of gamma-rays measured by Integral is about one thousand times less than what we would normally expect from a GRB," Sazonov said. A burst of gamma rays observed in 1998 in a closer galaxy appeared even fainter, about one hundred times less bright than GRB 031203. Astronomers, however, could not conclusively tell whether that was a genuine GRB because the bulk of its energy was emitted mostly as X-rays instead of gamma-rays. The work of Sazonov's team on GRB 031203 now suggests that intrinsically fainter GRBs can indeed exist. A team of US astronomers, coordinated by Alicia Soderberg from the California Institute of Technology, Pasadena (USA), studied the 'afterglow' of GRB 031203 and gave further support to this conclusion. The afterglow, emitted when a GRB's blastwave shocks the diffuse medium around it, can last weeks or months and progressively fades away. Using NASA's Chandra X-ray Observatory, Soderberg and her team saw that the X-ray brightness of the afterglow was about one thousand times fainter than that of typical distant GRBs. The team's observations with the Very Large Array telescope of the National Radio Astronomy Observatory in Socorro (USA) also revealed a source dimmer than usual. Sazonov and Soderberg explain that their teams looked carefully for signs that GRB 031203 could be tilted in such a way that most of its energy would escape Integral's detection. However, as Sazonov said, "the fact that most of the energy that we see is emitted in the gamma-ray domain, rather than in the X-rays, means that we are seeing the beam nearly on axis." It is, therefore, unlikely that much of its energy output can go unnoticed. This discovery suggests the existence of a new population of GRBs much closer but also dimmer than the majority of those known so far, which are very energetic but distant. Objects of this type may also be very numerous and thus produce more frequent bursts. The bulk of this population has so far escaped our attention because it lies at the limit of detection with past and present instruments. Integral, however, may be just sensitive enough to reveal a few more of them in the years to come. These could be just the tip of the iceberg and future gamma-ray observatories, such as the planned NASA's Swift mission, should be able to extend this search to GRBs of much lower energy, where many more of them are expected. NASA's Marshall Space Flight Center, Huntsville, Alabama, manages the Chandra programme for the Office of Space Science, NASA Headquarters, Washington DC, USA. Northrop Grumman of Redondo Beach, California, formerly TRW Inc., was the prime development contractor for the observatory. The Smithsonian Astrophysical Observatory controls science and flight operations from the Chandra X-ray Center in Cambridge, Massachusetts. Images and additional information about this result are available at: http://chandra.harvard.edu and http://chandra.nasa.gov

The Distribution of Fixation Durations during Reading: Effects of Stimulus Quality

ERIC Educational Resources Information Center

White, Sarah J.; Staub, Adrian

2012-01-01

Participants' eye movements were recorded as they read single sentences presented normally, presented entirely in faint text, or presented normally except for a single faint word. Fixations were longer when the entire sentence was faint than when the sentence was presented normally. In addition, fixations were much longer on a single faint word…

A Strong Limit on the Very-high-energy Emission from GRB 150323A

NASA Astrophysics Data System (ADS)

Abeysekara, A. U.; Archer, A.; Benbow, W.; Bird, R.; Brose, R.; Buchovecky, M.; Bugaev, V.; Connolly, M. P.; Cui, W.; Errando, M.; Falcone, A.; Feng, Q.; Finley, J. P.; Flinders, A.; Fortson, L.; Furniss, A.; Gillanders, G. H.; Hütten, M.; Hanna, D.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Johnson, C. A.; Kaaret, P.; Kar, P.; Kelley-Hoskins, N.; Kertzman, M.; Kieda, D.; Krause, M.; Krennrich, F.; Lang, M. J.; Lin, T. T. Y.; Maier, G.; McArthur, S.; Moriarty, P.; Mukherjee, R.; O’Brien, S.; Ong, R. A.; Park, N.; Perkins, J. S.; Petrashyk, A.; Pohl, M.; Popkow, A.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Richards, G. T.; Roache, E.; Rulten, C.; Sadeh, I.; Santander, M.; Sembroski, G. H.; Shahinyan, K.; Tyler, J.; Wakely, S. P.; Weiner, O. M.; Weinstein, A.; Wells, R. M.; Wilcox, P.; Wilhelm, A.; Williams, D. A.; Zitzer, B.; VERITAS Collaboration; Vurm, Indrek; Beloborodov, Andrei

2018-04-01

On 2015 March 23, the Very Energetic Radiation Imaging Telescope Array System (VERITAS) responded to a Swift-Burst Alert Telescope (BAT) detection of a gamma-ray burst, with observations beginning 270 s after the onset of BAT emission, and only 135 s after the main BAT emission peak. No statistically significant signal is detected above 140 GeV. The VERITAS upper limit on the fluence in a 40-minute integration corresponds to about 1% of the prompt fluence. Our limit is particularly significant because the very-high-energy (VHE) observation started only ∼2 minutes after the prompt emission peaked, and Fermi-Large Area Telescope observations of numerous other bursts have revealed that the high-energy emission is typically delayed relative to the prompt radiation and lasts significantly longer. Also, the proximity of GRB 150323A (z = 0.593) limits the attenuation by the extragalactic background light to ∼50% at 100–200 GeV. We conclude that GRB 150323A had an intrinsically very weak high-energy afterglow, or that the GeV spectrum had a turnover below ∼100 GeV. If the GRB exploded into the stellar wind of a massive progenitor, the VHE non-detection constrains the wind density parameter to be A ≳ 3 × 1011 g cm‑1, consistent with a standard Wolf–Rayet progenitor. Alternatively, the VHE emission from the blast wave would be weak in a very tenuous medium such as the interstellar medium, which therefore cannot be ruled out as the environment of GRB 150323A.

Possible Class of Nearby Gamma-Ray Burst / Gravitational Wave Sources

NASA Astrophysics Data System (ADS)

Norris, Jay P.

2003-10-01

A possible subclass of gamma-ray bursts - those with few, wide pulses, spectral lags of order one to several seconds, and soft spectra - has been identified. Their Log[N]-Log[Fp] distribution approximates a -3/2 power-law, suggesting homogeneity and relatively nearby sources. These mostly dim bursts account for ~ 50% of the BATSE sample of long bursts near that instrument's trigger threshold, suggesting that this subluminous class constitutes a more common variety than the more familiar burst sources which lie at truly cosmological distances. Theoretical scenarios predicted such a class, motivated by their exemplar GRB 980425 (SN 1998bw) lying at a distance of ~ 38 Mpc. The observations are explained by invoking off-axis viewing of the GRB jet and/or bulk Lorentz factors of order a few. Long-lag bursts show a tendency to concentrate near the Supergalactic Plane with a quadrupole moment of -0.10 +/- 0.04, similar to that for SNe type Ib/c within the same volume. The rate of the observed subluminous bursts is of order 14 that of SNe Ib/c. Evidence for a sequential relationship between SNe Ib/c and GRBs is critiqued for two cases, as simultaneity of the SN and GRB events may be important for detection of the expected gravitational wave signal; at most, SN to GRB delays appear to be a few days. SN asymmetries and ultrarelativistic GRB jets suggest the possibility of rapid rotation in the pre-collapse objects, a primary condition required for highly non-axisymmetric SN collapse to produce strong gravitational waves.

Grb2 mediates semaphorin-4D-dependent RhoA inactivation.

PubMed

Sun, Tianliang; Krishnan, Rameshkumar; Swiercz, Jakub M

2012-08-01

Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases ErbB-2 and Met. In cells expressing the plexin-B1-ErbB-2 receptor complex, ligand stimulation results in the activation of small GTPase RhoA and stimulation of cellular migration. By contrast, in cells expressing plexin-B1 and Met, ligand stimulation results in an association with the RhoGTPase-activating protein p190 RhoGAP and subsequent RhoA inactivation--a process that involves the tyrosine phosphorylation of plexin-B1 by Met. Inactivation of RhoA is necessary for Sema4D-mediated inhibition of cellular migration. It is, however, unknown how plexin-B1 phosphorylation regulates RhoGAP interaction and activity. Here we show that the activation of plexin-B1 by Sema4D and its subsequent tyrosine phosphorylation by Met creates a docking site for the SH2 domain of growth factor receptor bound-2 (Grb2). Grb2 is thereby recruited into the plexin-B1 receptor complex and, through its SH3 domain, interacts with p190 RhoGAP and mediates RhoA deactivation. Phosphorylation of plexin-B1 by Met and the recruitment of Grb2 have no effect on the R-RasGAP activity of plexin-B1, but are required for Sema4D-induced, RhoA-dependent antimigratory effects of Sema4D on breast cancer cells. These data show Grb2 as a direct link between plexin and p190-RhoGAP-mediated downstream signaling.

Reliability and validity of the Chinese pediatric voice handicap index.

PubMed

Liu, Kena; Liu, Shaofeng; Zhou, Zhou; Ren, Qinyi; Zhong, Jie; Luo, Renzhong; Qin, Huabiao; Zhang, Siyi; Ge, Pingjiang

2018-02-01

To evaluate the reliability and validity of the Chinese version of pediatric voice handicap index (pVHI). The original English version-pVHI was translated into Chinese. Parents of 52 children with voice dysphonia and 43 children with no history or symptoms of voice problems were asked to fill the Chinese pVHI questionnaires twice with an interval of 2 weeks. GRB (Grade, Roughness, Breathiness) scale was used for perceptual assessment by two otolaryngologists and one speech pathologist for each child's voice. The internal consistency was assessed using Cronbach's alpha coefficient. Pearson's correlation coefficient was used to evaluate the test-retest reliability. The Kendall's coefficient of concordance W was used to assess the consistency of GRB scores of 3 voice specialists. The nonparametric Mann-Whitney test was used to assess the differences between the dysphonia group and controls. The correlation between pVHI and GRB scores were assessed using Pearson's correlation coefficient. The internal consistency of total score and three subscales scores of Chinese pVHI were 0.788-0.944. The test-retest reliability was 0.631-0.887(P < .001). The pVHI scores of control group significantly were lower than the pathological group (P = .000). The GRB scores of 3 voice specialists have an excellent consistency (W = 0.694-0.807, P = .000). The pVHI scores positively correlated with GRB assessment (P < .01). The Chinese version of pVHI had a good reliability and validity. It can be applicable and useful supplementary tool for evaluating parents' perception of their children's dysphonia. Copyright © 2017. Published by Elsevier B.V.

An Evolving GeV Spectrum from Prompt to Afterglow: The Case of GRB 160509A

NASA Astrophysics Data System (ADS)

Tam, Pak-Hin Thomas; He, Xin-Bo; Tang, Qing-Wen; Wang, Xiang-Yu

2017-07-01

We present the high-energy emission properties of GRB 160509A, from its prompt mission to late afterglow phase. GRB 160509A contains two emission episodes: 0-40 s and 280-420 s after the burst onset ({t}0). The relatively high fluence of GRB 160509A allows us to establish an evolving spectrum above 100 MeV. During the first emission episode, the >100 MeV spectrum is soft with Γ ≥ 3.0, which can be smoothly connected to keV energies with a Band function with or without a high-energy cutoff. The >100 MeV spectrum rapidly changes to a hard spectrum with Γ ≤ 1.5 after {t}0+40 s. The existence of very energetic photons, e.g., a 52 GeV that arrives at {t}0+77 s and a 29 GeV that arrives at {t}0+70 ks, is hard to reconcile by the synchrotron emission from forward-shock electrons, but is likely due to an inverse-Compton (IC) mechanism (e.g., synchrotron self-Compton emission). A soft spectrum (Γ ˜ 2) between 300 and 1000 s after the burst onset is also found at a significance of about 2 standard deviations, which suggests a different emission mechanism at work for this short period of time. GRB 160509A represents the latest example where IC emission has to be taken into account in explaining the afterglow GeV emission, which had been suggested long before the launch of the Fermi Large Area Telescope.

Early-time VLA Observations and Broadband Afterglow Analysis of the Fermi/LAT Detected GRB 130907A

NASA Astrophysics Data System (ADS)

Veres, Péter; Corsi, Alessandra; Frail, Dale A.; Cenko, S. Bradley; Perley, Daniel A.

2015-09-01

We present multi-wavelength observations of the hyper-energetic gamma-ray burst (GRB) 130907A, a Swift-discovered burst with early radio observations starting at ≈4 hr after the γ-ray trigger. GRB 130907A was also detected by the Fermi/LAT instrument and at late times showed a strong spectral evolution in X-rays. We focus on the early-time radio observations, especially at >10 GHz, to attempt to identify reverse shock signatures. While our radio follow-up of GRB 130907A ranks among the earliest observations of a GRB with the Karl G. Jansky Very Large Array, we did not see an unambiguous signature of a reverse shock. While a model with both reverse and forward shock can correctly describe the observations, the data is not constraining enough to decide upon the presence of the reverse-shock component. We model the broadband data using a simple forward-shock synchrotron scenario with a transition from a wind environment to a constant density interstellar medium (ISM) in order to account for the observed features. Within the confines of this model, we also derive the underlying physical parameters of the fireball, which are within typical ranges except for the wind density parameter (A*), which is higher than those for bursts with wind-ISM transition, but typical for the general population of bursts. We note the importance of early-time radio observations of the afterglow (and of well-sampled light curves) for unambiguously identifying the potential contribution of the reverse shock.

Constraints on millisecond magnetars as the engines of prompt emission in gamma-ray bursts

NASA Astrophysics Data System (ADS)

Beniamini, Paz; Giannios, Dimitrios; Metzger, Brian D.

2017-12-01

We examine millisecond magnetars as central engines of gamma-ray bursts' (GRBs) prompt emission. Using the protomagnetar wind model of Metzger et al., we estimate the temporal evolution of the magnetization and power injection at the base of the GRB jet and apply these to different prompt emission models to make predictions for the GRB energetics, spectra and light curves. We investigate both shock and magnetic reconnection models for the particle acceleration, as well as the effects of energy dissipation across optically thick and thin regions of the jet. The magnetization at the base of the jet, σ0, is the main parameter driving the GRB evolution in the magnetar model and the emission is typically released for 100 ≲σ0 ≲3000. Given the rapid increase in σ0 as the protomagnetar cools and its neutrino-driven mass loss subsides, the GRB duration is typically limited to ≲100 s. This low baryon loading at late times challenges magnetar models for ultralong GRBs, though black hole models likely run into similar difficulties without substantial entrainment from the jet walls. The maximum radiated gamma-ray energy is ≲5 × 1051 erg, significantly less than the magnetar's total initial rotational energy and in strong tension with the high end of the observed GRB energy distribution. However, the gradual magnetic dissipation model applied to a magnetar central engine, naturally explains several key observables of typical GRBs, including energetics, durations, stable peak energies, spectral slopes and a hard to soft evolution during the burst.

CONSTRAINTS ON THE EMISSION MODEL OF THE 'NAKED-EYE BURST' GRB 080319B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A. A.; Abeysekara, A. U.; Linnemann, J. T.

On 2008 March 19, one of the brightest gamma-ray bursts (GRBs) ever recorded was detected by several ground- and space-based instruments spanning the electromagnetic spectrum from radio to gamma rays. With a peak visual magnitude of 5.3, GRB 080319B was dubbed the 'naked-eye' GRB, as an observer under dark skies could have seen the burst without the aid of an instrument. Presented here are results from observations of the prompt phase of GRB 080319B taken with the Milagro TeV observatory. The burst was observed at an elevation angle of 47 Degree-Sign . Analysis of the data is performed using bothmore » the standard air shower method and the scaler or single-particle technique, which results in a sensitive energy range that extends from {approx}5 GeV to >20 TeV. These observations provide the only direct constraints on the properties of the high-energy gamma-ray emission from GRB 080319B at these energies. No evidence for emission is found in the Milagro data, and upper limits on the gamma-ray flux above 10 GeV are derived. The limits on emission between {approx}25 and 200 GeV are incompatible with the synchrotron self-Compton model of gamma-ray production and disfavor a corresponding range (2 eV-16 eV) of assumed synchrotron peak energies. This indicates that the optical photons and soft ({approx}650 keV) gamma rays may not be produced by the same electron population.« less

Grb-IR: A SH2-Domain-Containing Protein that Binds to the Insulin Receptor and Inhibits Its Function

NASA Astrophysics Data System (ADS)

Liu, Feng; Roth, Richard A.

1995-10-01

To identify potential signaling molecules involved in mediating insulin-induced biological responses, a yeast two-hybrid screen was performed with the cytoplasmic domain of the human insulin receptor (IR) as bait to trap high-affinity interacting proteins encoded by human liver or HeLa cDNA libraries. A SH2-domain-containing protein was identified that binds with high affinity in vitro to the autophosphorylated IR. The mRNA for this protein was found by Northern blot analyses to be highest in skeletal muscle and was also detected in fat by PCR. To study the role of this protein in insulin signaling, a full-length cDNA encoding this protein (called Grb-IR) was isolated and stably expressed in Chinese hamster ovary cells overexpressing the human IR. Insulin treatment of these cells resulted in the in situ formation of a complex of the IR and the 60-kDa Grb-IR. Although almost 75% of the Grb-IR protein was bound to the IR, it was only weakly tyrosine-phosphorylated. The formation of this complex appeared to inhibit the insulin-induced increase in tyrosine phosphorylation of two endogenous substrates, a 60-kDa GTPase-activating-protein-associated protein and, to a lesser extent, IR substrate 1. The subsequent association of this latter protein with phosphatidylinositol 3-kinase also appeared to be inhibited. These findings raise the possibility that Grb-IR is a SH2-domain-containing protein that directly complexes with the IR and serves to inhibit signaling or redirect the IR signaling pathway.

Fainting

MedlinePlus

... in older people. Some causes of fainting include Heat or dehydration Emotional distress Standing up too quickly Certain medicines Drop in blood sugar Heart problems When someone faints, make sure that the ...

On the Time Evolution of Gamma-Ray Burst Pulses: A Self-Consistent Description.

PubMed

Ryde; Svensson

2000-01-20

For the first time, the consequences of combining two well-established empirical relations that describe different aspects of the spectral evolution of observed gamma-ray burst (GRB) pulses are explored. These empirical relations are (1) the hardness-intensity correlation and (2) the hardness-photon fluence correlation. From these we find a self-consistent, quantitative, and compact description for the temporal evolution of pulse decay phases within a GRB light curve. In particular, we show that in the case in which the two empirical relations are both valid, the instantaneous photon flux (intensity) must behave as 1&solm0;&parl0;1+t&solm0;tau&parr0;, where tau is a time constant that can be expressed in terms of the parameters of the two empirical relations. The time evolution is fully defined by two initial constants and two parameters. We study a complete sample of 83 bright GRB pulses observed by the Compton Gamma-Ray Observatory and identify a major subgroup of GRB pulses ( approximately 45%) which satisfy the spectral-temporal behavior described above. In particular, the decay phase follows a reciprocal law in time. It is unclear what physics causes such a decay phase.

Evolution of the polarization of the optical afterglow of the gamma-ray burst GRB030329.

PubMed

Greiner, Jochen; Klose, Sylvio; Reinsch, Klaus; Schmid, Hans Martin; Sari, Re'em; Hartmann, Dieter H; Kouveliotou, Chryssa; Rau, Arne; Palazzi, Eliana; Straubmeier, Christian; Stecklum, Bringfried; Zharikov, Sergej; Tovmassian, Gaghik; Bärnbantner, Otto; Ries, Christoph; Jehin, Emmanuel; Henden, Arne; Kaas, Anlaug A; Grav, Tommy; Hjorth, Jens; Pedersen, Holger; Wijers, Ralph A M J; Kaufer, Andreas; Park, Hye-Sook; Williams, Grant; Reimer, Olaf

2003-11-13

The association of a supernova with GRB030329 strongly supports the 'collapsar' model of gamma-ray bursts, where a relativistic jet forms after the progenitor star collapses. Such jets cannot be spatially resolved because gamma-ray bursts lie at cosmological distances; their existence is instead inferred from 'breaks' in the light curves of the afterglows, and from the theoretical desire to reduce the estimated total energy of the burst by proposing that most of it comes out in narrow beams. Temporal evolution of the polarization of the afterglows may provide independent evidence for the jet structure of the relativistic outflow. Small-level polarization ( approximately 1-3 per cent) has been reported for a few bursts, but its temporal evolution has yet to be established. Here we report polarimetric observations of the afterglow of GRB030329. We establish the polarization light curve, detect sustained polarization at the per cent level, and find significant variability. The data imply that the afterglow magnetic field has a small coherence length and is mostly random, probably generated by turbulence, in contrast with the picture arising from the high polarization detected in the prompt gamma-rays from GRB021206 (ref. 18).

Gamma-ray Burst Prompt Correlations: Selection and Instrumental Effects

NASA Astrophysics Data System (ADS)

Dainotti, M. G.; Amati, L.

2018-05-01

The prompt emission mechanism of gamma-ray bursts (GRB) even after several decades remains a mystery. However, it is believed that correlations between observable GRB properties, given their huge luminosity/radiated energy and redshift distribution extending up to at least z ≈ 9, are promising possible cosmological tools. They also may help to discriminate among the most plausible theoretical models. Nowadays, the objective is to make GRBs standard candles, similar to supernovae (SNe) Ia, through well-established and robust correlations. However, differently from SNe Ia, GRBs span over several order of magnitude in their energetics, hence they cannot yet be considered standard candles. Additionally, being observed at very large distances, their physical properties are affected by selection biases, the so-called Malmquist bias or Eddington effect. We describe the state of the art on how GRB prompt correlations are corrected for these selection biases to employ them as redshift estimators and cosmological tools. We stress that only after an appropriate evaluation and correction for these effects, GRB correlations can be used to discriminate among the theoretical models of prompt emission, to estimate the cosmological parameters and to serve as distance indicators via redshift estimation.

Revisiting gamma-ray burst afterglows with time-dependent parameters

NASA Astrophysics Data System (ADS)

Yang, Chao; Zou, Yuan-Chuan; Chen, Wei; Liao, Bin; Lei, Wei-Hua; Liu, Yu

2018-02-01

The relativistic external shock model of gamma-ray burst (GRB) afterglows has been established with five free parameters, i.e., the total kinetic energy E, the equipartition parameters for electrons {{ε }}{{e}} and for the magnetic field {{ε }}{{B}}, the number density of the environment n and the index of the power-law distribution of shocked electrons p. A lot of modified models have been constructed to consider the variety of GRB afterglows, such as: the wind medium environment by letting n change with radius, the energy injection model by letting kinetic energy change with time and so on. In this paper, by assuming all four parameters (except p) change with time, we obtain a set of formulas for the dynamics and radiation, which can be used as a reference for modeling GRB afterglows. Some interesting results are obtained. For example, in some spectral segments, the radiated flux density does not depend on the number density or the profile of the environment. As an application, through modeling the afterglow of GRB 060607A, we find that it can be interpreted in the framework of the time dependent parameter model within a reasonable range.

Software development for a gamma-ray burst rapid-response observatory in the US Virgin Islands.

NASA Astrophysics Data System (ADS)

Davis, K. A.; Giblin, T. W.; Neff, J. E.; Hakkila, J.; Hartmann, D.

2004-12-01

The site is situated near the crest of Crown Mountain on the island of St. Thomas in the US Virgin Islands. The observing site is strategically located 65 W longitude, placing it as the most eastern GRB-dedicated observing site in the western hemisphere. The observatory has a 0.5 m robotic telescope and a Marconi 4240 2048 by 2048 CCD with BVRI filters. The field of view is identical to that of the XRT onboard Swift, 19 by 19 arc minutes. The telescope is operated through the Talon telescope control software. The observatory is notified of a burst trigger through the GRB Coordinates Network (GCN). This GCN notification is received through a socket connection to the control computer on site. A Perl script passes this information to the Talon software, which automatically interrupts concurrent observations and inserts a new GRB observing schedule. Once the observations are made the resulting images are then analyzed in IRAF. A source extraction is necessary to identify known sources and the optical transient. The system is being calibrated for automatic GRB response and is expected to be ready to follow up Swift observations. This work has been supported by NSF and NASA-EPSCoR.

Exploring the Properties of Choked Gamma-ray Bursts with IceCube’s High-energy Neutrinos

NASA Astrophysics Data System (ADS)

Denton, Peter B.; Tamborra, Irene

2018-03-01

Long duration gamma-ray bursts (GRBs) have often been considered the natural evolution of some core-collapse supernova (CCSN) progenitors. However, the fraction of CCSNe linked to astrophysical jets and their properties are still poorly constrained. While any successful astrophysical jet harbored in a CCSN should produce high-energy neutrinos, photons may be able to successfully escape the stellar envelope only for a fraction of progenitors, possibly leading to the existence of high-luminosity, low-luminosity, and not-electromagnetically bright (“choked”) GRBs. By postulating a CCSN–GRB connection, we accurately model the jet physics within the internal-shock GRB model and assume scaling relations for the GRB parameters that depend on the Lorentz boost factor Γ. The IceCube high-energy neutrino flux is then employed as an upper limit of the neutrino background from electromagnetically bright and choked GRBs to constrain the jet and the progenitor properties. The current IceCube data set is compatible with up to 1% of all CCSNe harboring astrophysical jets. Interestingly, those jets are predominantly choked. Our findings suggest that neutrinos can be powerful probes of the burst physics and can provide major insights on the CCSN–GRB connection.

A New Paradigm for Gamma Ray Bursts: Long Term Accretion Rate Modulation by an External Accretion Disk

NASA Technical Reports Server (NTRS)

Cannizzo, John; Gehrels, Neil

2009-01-01

We present a new way of looking at the very long term evolution of GRBs in which the disk of material surrounding the putative black hole powering the GRB jet modulates the mass flow, and hence the efficacy of the process that extracts rotational energy from the black hole and inner accretion disk. The pre-Swift paradigm of achromatic, shallow-to-steep "breaks" in the long term GRB light curves has not been borne out by detailed Swift data amassed in the past several years. We argue that, given the initial existence of a fall-back disk near the progenitor, an unavoidable consequence will be the formation of an "external disk" whose outer edge continually moves to larger radii due to angular momentum transport and lack of a confining torque. The mass reservoir at large radii moves outward with time and gives a natural power law decay to the GRB light curves. In this model, the different canonical power law decay segments in the GRB identified by Zhang et al. and Nousek et al. represent different physical states of the accretion disk. We identify a physical disk state with each power law segment.

GRB 080319B: A Naked-Eye Stellar Blast from the Distant Universe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Racusin, J. L.; Burrows, D. N.

On behalf of a large international collaboration [1], we present the unprecedented broadband observations of GRB 080319B, whose prompt optical emission peaked at a visual magnitude of 5.3, making it briefly visible with the naked eye. GRB 080319B was discovered by Swift and captured in exquisite detail by ground based wide-field telescopes, imaging the burst location from before the time of the explosion. The combination of these unique optical data with simultaneous {gamma}-ray observations provides powerful diagnostics of the detailed physics of this explosion within seconds of its formation. We show that the prompt optical and {gamma}-ray emissions from thismore » event arise from different spectral components within the same physical region located at a large distance from the source, implying an extremely relativistic outflow. Our observations also provide good evidence for a bright reverse shock component. The chromatic behavior of the broadband afterglow is consistent with viewing the GRB down the very narrow inner core of a two-component jet that is expanding into a wind-like environment consistent with the massive star origin of long GRBs.« less

MODELING THE AFTERGLOW OF THE POSSIBLE FERMI -GBM EVENT ASSOCIATED WITH GW150914

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morsony, Brian J.; Workman, Jared C.; Ryan, Dominic M., E-mail: morsony@astro.umd.edu

2016-07-10

We model the possible afterglow of the Fermi Gamma-ray Burst Monitor (GBM) event associated with LIGO detection GW150914, under the assumption that the gamma-rays are produced by a short GRB-like relativistic outflow. We model GW150914-GBM as both a weak, on-axis short GRB and normal short GRB seen far off-axis. Given the large uncertainty in the position of GW150914, we determine that the best chance of finding the afterglow is with ASKAP or possibly the Murchinson Widefield Array (MWA), with the flux from an off-axis short GRB reaching 0.2–4 mJy (0.12–16 mJy) at 150 MHz (863.5 MHz) by 1–12 months aftermore » the initial event. At low frequencies, the source would evolve from a hard to soft spectrum over several months. The radio afterglow would be detectable for several months to years after it peaks, meaning the afterglow may still be detectable and increasing in brightness NOW (2016 mid-July). With a localization from the MWA or ASKAP, the afterglow would be detectable at higher radio frequencies with the ATCA and in X-rays with Chandra or XMM .« less

Multicolour modelling of SN 2013dx associated with GRB 130702A★

NASA Astrophysics Data System (ADS)

Volnova, A. A.; Pruzhinskaya, M. V.; Pozanenko, A. S.; Blinnikov, S. I.; Minaev, P. Yu.; Burkhonov, O. A.; Chernenko, A. M.; Ehgamberdiev, Sh. A.; Inasaridze, R.; Jelinek, M.; Khorunzhev, G. A.; Klunko, E. V.; Krugly, Yu. N.; Mazaeva, E. D.; Rumyantsev, V. V.; Volvach, A. E.

2017-05-01

We present optical observations of SN 2013dx, related to the Fermi burst GRB 130702A, which occurred at red shift z = 0.145. It is the second-best sampled gamma-ray burst (GRB)/supernova (SN) after SN 1998bw. The observational light curves contain more than 280 data points in the uBgrRiz filters until 88 d after the burst, and the data were collected from our observational collaboration (Maidanak Observatory, Abastumani Observatory, Crimean Astrophysical Observatory, Mondy Observatory, National Observatory of Turkey and Observatorio del Roque de los Muchachos) and from the literature. We model numerically the multicolour light curves using the one-dimensional radiation hydrodynamical code stella, previously widely implemented for modelling typical non-GRB SNe. The best-fitting model has the following parameters: pre-SN star mass M = 25 M⊙; mass of the compact remnant MCR = 6 M⊙; total energy of the outburst Eoburst = 3.5 × 1052 erg; pre-supernova star radius R = 100 R⊙; M_^{56Ni} = 0.2 M_{⊙}, which is totally mixed through the ejecta; MO = 16.6 M⊙; MSi = 1.2 M⊙ and MFe = 1.2 M⊙, and the radiative efficiency of the SN is 0.1 per cent.

Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10

PubMed Central

Cheng, Wei; Huang, Po-Chun; Chao, Hsiao-Mei; Jeng, Yung-Ming; Hsu, Hey-Chi; Pan, Hung-Wei; Hwu, Wuh-Liang; Lee, Yu-May

2017-01-01

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a major cause of cancer-related death worldwide. Previously, we demonstrated that glypican-3 (GPC3) is highly expressed in HCC, and that GPC3 induces oncogenicity and promotes the growth of cancer cells through IGF-1 receptor (IGF-1R). In the present study, we investigated the mechanisms of GPC3-mediated enhancement of IGF-1R signaling. We demonstrated that GPC3 decreased IGF-1-induced IGF-1R ubiquitination and degradation and increased c-Myc protein levels. GPC3 bound to Grb10, a mediator of ligand-induced receptor ubiquitination, and the overexpression of Grb10 blocked GPC3-enhanced IGF-1-induced ERK phosphorylation. GPC3 promoted the growth of NIH3T3 and PLC-PRF-5 cells in serum-free medium but did not promote the growth of IGF-1R negative R- cells. Grb10 overexpression decreased GPC3-promoted cell growth. Therefore, the present study elucidates the mechanisms of GPC3-induced oncogenicity, which may highlight new strategies for the treatment of HCC. PMID:29113314

Polarization of Gamma-Ray Bursts in the Dissipative Photosphere Model

NASA Astrophysics Data System (ADS)

Lundman, Christoffer; Vurm, Indrek; Beloborodov, Andrei M.

2018-04-01

The MeV spectral peak of gamma-ray bursts (GRBs) is best explained as photospheric emission from a dissipative relativistic jet. The observed non-blackbody spectrum shows that sub-photospheric dissipation involves both thermal plasma heating and injection of nonthermal particles, which quickly cool through inverse Compton scattering and emission of synchrotron radiation. Synchrotron photons emitted around and above the photosphere are predicted to dominate the low-energy part of the GRB spectrum, starting from roughly a decade in energy below the MeV peak. We show that this leads to a unique polarization signature: a rise in GRB polarization toward lower energies. We compute the polarization degree of GRB radiation as a function of photon energy for a generic jet model, and show the predictions for GRBs 990123, 090902B, and 110721A. The expected polarization is significant in the X-ray band, in particular for bursts similar to GRB 090902B. The model predicts that radiation in the MeV peak (and at higher energies) is unpolarized as long as the jet is approximately uniform on angular scales δθ ≳ Γ‑1 where Γ is the bulk Lorentz factor of the jet.

Particle dark matter: A multimessenger endeavour

NASA Astrophysics Data System (ADS)

Regis, M.

2017-01-01

The search for dark matter (DM) as a new, yet undiscovered, particle is explored through a complex host of different signals, from collider to direct and indirect searches. A special focus is dedicated to the latter ones, covering the full electromagnetic spectrum (from radio to gamma-rays), charged cosmic-rays and neutrinos. The expected DM signals are by definition faint, but the possibility to exploit a wide-field investigation offers promising prospects. In this brief review, I summarize the state-of-the-art in the search for particle DM signals, exploring some new ideas that are emerging in the effort of the scientific community to understand the elusive nature of DM.

The THESEUS space mission concept: science case, design and expected performances

NASA Astrophysics Data System (ADS)

Amati, L.; O'Brien, P.; Götz, D.; Bozzo, E.; Tenzer, C.; Frontera, F.; Ghirlanda, G.; Labanti, C.; Osborne, J. P.; Stratta, G.; Tanvir, N.; Willingale, R.; Attina, P.; Campana, R.; Castro-Tirado, A. J.; Contini, C.; Fuschino, F.; Gomboc, A.; Hudec, R.; Orleanski, P.; Renotte, E.; Rodic, T.; Bagoly, Z.; Blain, A.; Callanan, P.; Covino, S.; Ferrara, A.; Le Floch, E.; Marisaldi, M.; Mereghetti, S.; Rosati, P.; Vacchi, A.; D'Avanzo, P.; Giommi, P.; Piranomonte, S.; Piro, L.; Reglero, V.; Rossi, A.; Santangelo, A.; Salvaterra, R.; Tagliaferri, G.; Vergani, S.; Vinciguerra, S.; Briggs, M.; Campolongo, E.; Ciolfi, R.; Connaughton, V.; Cordier, B.; Morelli, B.; Orlandini, M.; Adami, C.; Argan, A.; Atteia, J.-L.; Auricchio, N.; Balazs, L.; Baldazzi, G.; Basa, S.; Basak, R.; Bellutti, P.; Bernardini, M. G.; Bertuccio, G.; Braga, J.; Branchesi, M.; Brandt, S.; Brocato, E.; Budtz-Jorgensen, C.; Bulgarelli, A.; Burderi, L.; Camp, J.; Capozziello, S.; Caruana, J.; Casella, P.; Cenko, B.; Chardonnet, P.; Ciardi, B.; Colafrancesco, S.; Dainotti, M. G.; D'Elia, V.; De Martino, D.; De Pasquale, M.; Del Monte, E.; Della Valle, M.; Drago, A.; Evangelista, Y.; Feroci, M.; Finelli, F.; Fiorini, M.; Fynbo, J.; Gal-Yam, A.; Gendre, B.; Ghisellini, G.; Grado, A.; Guidorzi, C.; Hafizi, M.; Hanlon, L.; Hjorth, J.; Izzo, L.; Kiss, L.; Kumar, P.; Kuvvetli, I.; Lavagna, M.; Li, T.; Longo, F.; Lyutikov, M.; Maio, U.; Maiorano, E.; Malcovati, P.; Malesani, D.; Margutti, R.; Martin-Carrillo, A.; Masetti, N.; McBreen, S.; Mignani, R.; Morgante, G.; Mundell, C.; Nargaard-Nielsen, H. U.; Nicastro, L.; Palazzi, E.; Paltani, S.; Panessa, F.; Pareschi, G.; Pe'er, A.; Penacchioni, A. V.; Pian, E.; Piedipalumbo, E.; Piran, T.; Rauw, G.; Razzano, M.; Read, A.; Rezzolla, L.; Romano, P.; Ruffini, R.; Savaglio, S.; Sguera, V.; Schady, P.; Skidmore, W.; Song, L.; Stanway, E.; Starling, R.; Topinka, M.; Troja, E.; van Putten, M.; Vanzella, E.; Vercellone, S.; Wilson-Hodge, C.; Yonetoku, D.; Zampa, G.; Zampa, N.; Zhang, B.; Zhang, B. B.; Zhang, S.; Zhang, S.-N.; Antonelli, A.; Bianco, F.; Boci, S.; Boer, M.; Botticella, M. T.; Boulade, O.; Butler, C.; Campana, S.; Capitanio, F.; Celotti, A.; Chen, Y.; Colpi, M.; Comastri, A.; Cuby, J.-G.; Dadina, M.; De Luca, A.; Dong, Y.-W.; Ettori, S.; Gandhi, P.; Geza, E.; Greiner, J.; Guiriec, S.; Harms, J.; Hernanz, M.; Hornstrup, A.; Hutchinson, I.; Israel, G.; Jonker, P.; Kaneko, Y.; Kawai, N.; Wiersema, K.; Korpela, S.; Lebrun, V.; Lu, F.; MacFadyen, A.; Malaguti, G.; Maraschi, L.; Melandri, A.; Modjaz, M.; Morris, D.; Omodei, N.; Paizis, A.; Páta, P.; Petrosian, V.; Rachevski, A.; Rhoads, J.; Ryde, F.; Sabau-Graziati, L.; Shigehiro, N.; Sims, M.; Soomin, J.; Szécsi, D.; Urata, Y.; Uslenghi, M.; Valenziano, L.; Vianello, G.; Vojtech, S.; Watson, D.; Zicha, J.

2018-07-01

THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5-1 arcmin localization, an energy band extending from several MeV down to 0.3 keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7 m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing the main open issues in cosmology such as, e.g., star formation rate and metallicity evolution of the inter-stellar and intra-galactic medium up to redshift ∼ 10, signatures of Pop III stars, sources and physics of re-ionization, and the faint end of the galaxy luminosity function. In addition, it will provide unprecedented capability to monitor the X-ray variable sky, thus detecting, localizing, and identifying the electromagnetic counterparts to sources of gravitational radiation, which may be routinely detected in the late '20s/early '30s by next generation facilities like aLIGO/ aVirgo, eLISA, KAGRA, and Einstein Telescope. THESEUS will also provide powerful synergies with the next generation of multi-wavelength observatories (e.g., LSST, ELT, SKA, CTA, ATHENA).

Jets in Hydrogen-poor Superluminous Supernovae: Constraints from a Comprehensive Analysis of Radio Observations

NASA Astrophysics Data System (ADS)

Coppejans, D. L.; Margutti, R.; Guidorzi, C.; Chomiuk, L.; Alexander, K. D.; Berger, E.; Bietenholz, M. F.; Blanchard, P. K.; Challis, P.; Chornock, R.; Drout, M.; Fong, W.; MacFadyen, A.; Migliori, G.; Milisavljevic, D.; Nicholl, M.; Parrent, J. T.; Terreran, G.; Zauderer, B. A.

2018-03-01

The energy source powering the extreme optical luminosity of hydrogen-stripped superluminous supernovae (SLSNe-I) is not known, but recent studies have highlighted the case for a central engine. Radio and/or X-ray observations are best placed to track the fastest ejecta and probe the presence of outflows from a central engine. We compile all the published radio observations of SLSNe-I to date and present three new observations of two new SLSNe-I. None were detected. Through modeling the radio emission, we constrain the subparsec environments and possible outflows in SLSNe-I. In this sample, we rule out on-axis collimated relativistic jets of the kind detected in gamma-ray bursts (GRBs). We constrain off-axis jets with opening angles of 5° (30°) to energies of {E}{{k}}< 4× {10}50 {erg} ({E}{{k}}< {10}50 {erg}) in environments shaped by progenitors with mass-loss rates of \\dot{M}< {10}-4 {M}ȯ {yr}}-1 (\\dot{M}< {10}-5 {M}ȯ {yr}}-1) for all off-axis angles, assuming fiducial values {ε }e=0.1 and {ε }B=0.01. The deepest limits rule out emission of the kind seen in faint uncollimated GRBs (with the exception of GRB 060218) and from relativistic SNe. Finally, for the closest SLSN-I, SN 2017egm, we constrain the energy of an uncollimated nonrelativistic outflow like those observed in normal SNe to {E}{{k}}≲ {10}48 erg.

Prospects for GRB science with the Fermi Large Area Telescope

DOE PAGES

Band, D. L.; Axelsson, M.; Baldini, L.; ...

2009-08-04

The Large Area Telescope (LAT) instrument on the Fermi mission will reveal the rich spectral and temporal gamma-ray burst (GRB) phenomena in the >100 MeV band. The synergy with Fermi's Gamma-ray Burst Monitor detectors will link these observations to those in the well explored 10-1000 keV range; the addition of the >100 MeV band observations will resolve theoretical uncertainties about burst emission in both the prompt and afterglow phases. Trigger algorithms will be applied to the LAT data both onboard the spacecraft and on the ground. Furthermore, the sensitivity of these triggers will differ because of the available computing resourcesmore » onboard and on the ground. Here we present the LAT's burst detection methodologies and the instrument's GRB capabilities.« less

[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2].

PubMed

Vidal, Michel; Liu, Wang Qing; Gril, Brunile; Assayag, Franck; Poupon, Marie-France; Garbay, Christiane

2004-01-01

Cellular signaling pathways induced by growth-factor receptors are frequently deregulated in cancer. Anti-tumor agents that inhibit their enzymatic tyrosine kinase activity have been designed and are now used in human chemotherapy. We propose here an alternative way to interrupt over-expressed signaling by inhibiting protein-protein interactions that involve either the over-expressed proteins or proteins located downstream. The adaptor protein Grb2 over-expressed in connection with HER2/ErbB2/neu in Ras signaling pathway was chosen as a target. Peptides with very high affinity for Grb2 were rationally designed from structural data. Their capacity to interrupt the signaling pathway, their anti-proliferative activity as well as their potential anti-tumor properties are described.

Fermi Observations of High-Energy Gamma-Ray Emission from GRB 080916C

DOE PAGES

Abdo, A. A.; Ackermann, M.; Arimoto, M.; ...

2009-02-19

Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. Finally, the known distance of the burstmore » enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.« less

Near-infrared instrumentation for rapid-response astronomy

NASA Astrophysics Data System (ADS)

Capone, John Isaac

gamma-ray bursts (GRBs) are the Universe's most luminous transient events. Since the discovery of GRBs was announced in 1973, efforts have been ongoing to obtain data over a broader range of the electromagnetic spectrum at the earliest possible times following the initial detection. The discovery of the theorized "afterglow'' emission in radio through X-ray bands in the late 1990s confirmed the cosmological nature of these events. At present, GRB afterglows are among the best probes of the early Universe (z ≥ 9). In addition to informing theories about GRBs themselves, observations of afterglows probe the circum-burst medium (CBM), properties of the host galaxies and the progress of cosmic reionization. To explore the early-time variability of afterglows, I have developed a generalized analysis framework which models near-infrared (NIR), optical, ultra-violet (UV) and X-ray light curves without assuming an underlying model. These fits are then used to construct the spectral energy distribution (SED) of afterglows at arbitrary times within the observed window. Physical models are then used to explore the evolution of the SED parameter space with time. I demonstrate that this framework produces evidence of the photodestruction of dust in the CBM of GRB 120119A, similar to the findings from a previous study of this afterglow. The framework is additionally applied to the afterglows of GRB 140419A and GRB 080607. In these cases the evolution of the SEDs appears consistent with the standard fireball model. Having introduced the scientific motivations for early-time observations, I introduce the Rapid Infrared Imager-Spectrometer (RIMAS). Once commissioned on the 4.3 meter Discovery Channel Telescope (DCT), RIMAS will be used to study the afterglows of GRBs through photometric and spectroscopic observations beginning within minutes of the initial burst. The instrument will operate in the NIR, from 0.97 microm to 2.37 microm, permitting the detection of very high redshift (z ≥ 7) afterglows which are attenuated at shorter wavelengths by Lyman-alpha absorption in the intergalactic medium (IGM). A majority of my graduate work has been spent designing and aligning RIMAS's cryogenic ( 80 K) optical systems. Design efforts have included an original camera used to image the field surrounding spectroscopic slits, tolerancing and optimizing all of the instrument's optics, thermal modeling of optomechanical systems, and modeling the diffraction efficiencies for some of the dispersive elements. To align the cryogenic optics, I developed a procedure that was successfully used for a majority of the instrument's sub-assemblies. My work on this cryogenic instrument has necessitated experimental and computational projects to design and validate designs of several subsystems. Two of these projects describe simple and effective measurements of optomechanical components in vacuum and at cryogenic temperatures using an 8-bit CCD camera. Models of heat transfer via electrical harnesses used to provide current to motors located within the cryostat are also presented.

Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.

PubMed

Odai, H; Sasaki, K; Iwamatsu, A; Nakamoto, T; Ueno, H; Yamagata, T; Mitani, K; Yazaki, Y; Hirai, H

1997-04-15

Grb2/Ash and Shc are the adapter proteins that link tyrosine-kinase receptors to Ras and make tyrosine-kinase functionally associated with receptors and Ras in fibroblasts and hematopoietic cells. Grb2/Ash and Shc have the SH3, SH2, or phosphotyrosine binding domains. These domains bind to proteins containing proline-rich regions or tyrosine-phosphorylated proteins and contribute to the association of Grb2/Ash and Shc with other signaling molecules. However, there could remain unidentified signaling molecules that physically and functionally interact with these adapter proteins and have biologically important roles in the signaling pathways. By using the GST fusion protein including the full length of Grb2/Ash, we have found that c-Cbl and an unidentified 135-kD protein (pp135) are associated with Grb2/Ash. We have also found that they become tyrosine-phosphorylated by treatment of a human leukemia cell line, UT-7, with granulocyte-macrophage colony-stimulating factor (GM-CSF). We have purified the pp135 by using GST-Grb2/Ash affinity column and have isolated the full-length complementary DNA (cDNA) encoding the pp135 using a cDNA probe, which was obtained by the degenerate polymerase chain reaction based on a peptide sequence of the purified pp135. The cloned cDNA has 3,958 nucleotides that contain a single long open reading frame of 3,567 nucleotides, encoding a 1,189 amino acid protein with a predicted molecular weight of approximately 133 kD. The deduced amino acid sequence reveals that pp135 is a protein that has one SH2, one SH3, and one proline-rich domain. The pp135, which contains two motifs conserved among the inositol polyphosphate-5-phosphatase proteins, was shown to have the inositol polyphosphate-5-phosphatase activity. The pp135 was revealed to associate constitutively with Grb2/Ash and inducibly with Shc using UT-7 cells stimulated with GM-CSF. In the cell lines derived from human chronic myelogenous leukemia, pp135 was constitutively tyrosine-phosphorylated and associated with Shc and Bcr-Abl. These facts suggest that pp135 is a signaling molecule that has a unique enzymatic activity and should play an important role in the signaling pathway triggered by GM-CSF and in the transformation of hematopoietic cells caused by Bcr-Abl.

GRB 090227B: THE MISSING LINK BETWEEN THE GENUINE SHORT AND LONG GAMMA-RAY BURSTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muccino, M.; Ruffini, R.; Bianco, C. L.

2013-02-15

The time-resolved spectral analysis of GRB 090227B, made possible by the Fermi-GBM data, allows us to identify in this source the missing link between the genuine short and long gamma-ray bursts (GRBs). Within the Fireshell model of the GRBs we predict genuine short GRBs: bursts with the same inner engine of the long bursts but endowed with a severely low value of the baryon load, B {approx}< 5 Multiplication-Sign 10{sup -5}. A first energetically predominant emission occurs at the transparency of the e {sup +} e {sup -} plasma, the Proper-GRB (P-GRB), followed by a softer emission, the extended afterglow.more » The typical separation between the two emissions is expected to be of the order of 10{sup -3}-10{sup -2} s. We identify the P-GRB of GRB 090227B in the first 96 ms of emission, where a thermal component with the temperature kT = (517 {+-} 28) keV and a flux comparable with the non-thermal part of the spectrum is observed. This non-thermal component as well as the subsequent emission, where there is no evidence for a thermal spectrum, is identified with the extended afterglow. We deduce a theoretical cosmological redshift z = 1.61 {+-} 0.14. We then derive the total energy E{sup tot}{sub e{sup +}e{sup -}}= (2.83{+-}0.15) Multiplication-Sign 10{sup 53} erg, the baryon load B = (4.13 {+-} 0.05) Multiplication-Sign 10{sup -5}, the Lorentz {Gamma} factor at transparency {Gamma}{sub tr} = (1.44 {+-} 0.01) Multiplication-Sign 10{sup 4}, and the intrinsic duration {Delta}t' {approx} 0.35 s. We also determine the average density of the circumburst medium (CBM), (n {sub CBM}) = (1.90 {+-} 0.20) Multiplication-Sign 10{sup -5} particles cm{sup -3}. There is no evidence of beaming in the system. In view of the energetics and of the baryon load of the source, as well as of the low interstellar medium and of the intrinsic timescale of the signal, we identify the GRB progenitor as a binary neutron star. From the recent progress in the theory of neutron stars, we obtain masses of the stars m {sub 1} = m {sub 2} = 1.34 M {sub Sun} and their corresponding radii R {sub 1} = R {sub 2} = 12.24 km and thickness of their crusts {approx}0.47 km, consistent with the above values of the baryon load, of the energetics and of the time duration of the event.« less

The high-redshift gamma-ray burst GRB 140515A. A comprehensive X-ray and optical study

NASA Astrophysics Data System (ADS)

Melandri, A.; Bernardini, M. G.; D'Avanzo, P.; Sánchez-Ramírez, R.; Nappo, F.; Nava, L.; Japelj, J.; de Ugarte Postigo, A.; Oates, S.; Campana, S.; Covino, S.; D'Elia, V.; Ghirlanda, G.; Gafton, E.; Ghisellini, G.; Gnedin, N.; Goldoni, P.; Gorosabel, J.; Libbrecht, T.; Malesani, D.; Salvaterra, R.; Thöne, C. C.; Vergani, S. D.; Xu, D.; Tagliaferri, G.

2015-09-01

High-redshift gamma-ray bursts (GRBs) offer several advantages when studying the distant Universe, providing unique information about the structure and properties of the galaxies in which they exploded. Spectroscopic identification with large ground-based telescopes has improved our knowledge of this kind of distant events. We present the multi-wavelength analysis of the high-zSwift GRB GRB 140515A (z = 6.327). The best estimate of the neutral hydrogen fraction of the intergalactic medium towards the burst is xHI ≤ 0.002. The spectral absorption lines detected for this event are the weakest lines ever observed in GRB afterglows, suggesting that GRB 140515A exploded in a very low-density environment. Its circum-burst medium is characterised by an average extinction (AV ~ 0.1) that seems to be typical of z ≥ 6 events. The observed multi-band light curves are explained either with a very hard injected spectrum (p = 1.7) or with a multi-component emission (p = 2.1). In the second case a long-lasting central engine activity is needed in order to explain the late time X-ray emission. The possible origin of GRB 140515A in a Pop III (or in a Pop II star with a local environment enriched by Pop III) massive star is unlikely. Based on observations collected at the European Southern Observatory, ESO, the VLT/Kueyen telescope, Paranal, Chile (proposal code: 093.A-0069), on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofísica de Canarias (programme 49-008), and on observations made with the Italian 3.6-m Telescopio Nazionale Galileo (TNG), operated by the Fundación Galileo Galilei of the INAF (Instituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofísica de Canarias (programme A26TAC_63).Appendix A is available in electronic form at http://www.aanda.org

GRB 170817A Associated with GW170817: Multi-frequency Observations and Modeling of Prompt Gamma-Ray Emission

NASA Astrophysics Data System (ADS)

Pozanenko, A. S.; Barkov, M. V.; Minaev, P. Yu.; Volnova, A. A.; Mazaeva, E. D.; Moskvitin, A. S.; Krugov, M. A.; Samodurov, V. A.; Loznikov, V. M.; Lyutikov, M.

2018-01-01

We present our observations of electromagnetic transients associated with GW170817/GRB 170817A using optical telescopes of Chilescope observatory and Big Scanning Antenna (BSA) of Pushchino Radio Astronomy Observatory at 110 MHz. The Chilescope observatory detected an optical transient of ∼19m on the third day in the outskirts of the galaxy NGC 4993; we continued observations following its rapid decrease. We put an upper limit of 1.5 × 104 Jy on any radio source with a duration of 10–60 s, which may be associated with GW170817/GRB 170817A. The prompt gamma-ray emission consists of two distinctive components—a hard short pulse delayed by ∼2 s with respect to the LIGO signal and softer thermal pulse with T ∼ 10 keV lasting for another ∼2 s. The appearance of a thermal component at the end of the burst is unusual for short GRBs. Both the hard and the soft components do not satisfy the Amati relation, making GRB 170817A distinctively different from other short GRBs. Based on gamma-ray and optical observations, we develop a model for the prompt high-energy emission associated with GRB 170817A. The merger of two neutron stars creates an accretion torus of ∼10‑2 M ⊙, which supplies the black hole with magnetic flux and confines the Blandford–Znajek-powered jet. We associate the hard prompt spike with the quasispherical breakout of the jet from the disk wind. As the jet plows through the wind with subrelativistic velocity, it creates a radiation-dominated shock that heats the wind material to tens of kiloelectron volts, producing the soft thermal component.

SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.

PubMed

Anafi, M; Kiefer, F; Gish, G D; Mbamalu, G; Iscove, N N; Pawson, T

1997-10-31

Ste20-related protein kinases have been implicated as regulating a range of cellular responses, including stress-activated protein kinase pathways and the control of cytoskeletal architecture. An important issue involves the identities of the upstream signals and regulators that might control the biological functions of mammalian Ste20-related protein kinases. HPK1 is a protein-serine/threonine kinase that possesses a Ste20-like kinase domain, and in transfected cells activates a protein kinase pathway leading to the stress-activated protein kinase SAPK/JNK. Here we have investigated candidate upstream regulators that might interact with HPK1. HPK1 possesses an N-terminal catalytic domain and an extended C-terminal tail with four proline-rich motifs. The SH3 domains of Grb2 bound in vitro to specific proline-rich motifs in the HPK1 tail and functioned synergistically to direct the stable binding of Grb2 to HPK1 in transfected Cos1 cells. Epidermal growth factor (EGF) stimulation did not affect the binding of Grb2 to HPK1 but induced recruitment of the Grb2.HPK1 complex to the autophosphorylated EGF receptor and to the Shc docking protein. Several activated receptor and cytoplasmic tyrosine kinases, including the EGF receptor, stimulated the tyrosine phosphorylation of the HPK1 serine/threonine kinase. These results suggest that HPK1, a mammalian Ste20-related protein-serine/threonine kinase, can potentially associate with protein-tyrosine kinases through interactions mediated by SH2/SH3 adaptors such as Grb2. Such interaction may provide a possible mechanism for cross-talk between distinct biochemical pathways following the activation of tyrosine kinases.

Evolution of the dust-to-metals ratio in high-redshift galaxies probed by GRB-DLAs

NASA Astrophysics Data System (ADS)

Wiseman, P.; Schady, P.; Bolmer, J.; Krühler, T.; Yates, R. M.; Greiner, J.; Fynbo, J. P. U.

2017-03-01

Context. Several issues regarding the nature of dust at high redshift remain unresolved: its composition, its production and growth mechanisms, and its effect on background sources. Aims: We provide a more accurate relation between dust depletion levels and dust-to-metals ratio (DTM), and to use the DTM to investigate the origin and evolution of dust in the high-redshift Universe via gamma-ray burst damped Lyman-alpha absorbers (GRB-DLAs). Methods: We use absorption-line measured metal column densities for a total of 19 GRB-DLAs, including five new GRB afterglow spectra from VLT/X-Shooter. We use the latest linear models to calculate the dust depletion strength factor in each DLA. Using these values we calculate total dust and metal column densities to determine a DTM. We explore the evolution of DTM with metallicity, and compare it to previous trends in DTM measured with different methods. Results: We find significant dust depletion in 16 of our 19 GRB-DLAs, yet 18 of the 19 have a DTM significantly lower than the Milky Way. We find that DTM is positively correlated with metallicity, which supports a dominant ISM grain-growth mode of dust formation. We find a substantial discrepancy between the dust content measured from depletion and that derived from the total V-band extinction, AV, measured by fitting the afterglow SED. We advise against using a measurement from one method to estimate that from the other until the discrepancy can be resolved. Based on observations collected at the European Southern Observatory, Paranal, Chile, Program IDs: 088.A-0051(B), 089.A-0067(B), 091.C-0934, 094.A-0134(A).

MONSTER IN THE DARK: THE ULTRALUMINOUS GRB 080607 AND ITS DUSTY ENVIRONMENT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perley, D. A.; Morgan, A. N.; Miller, A. A.

2011-02-15

We present early-time optical through infrared photometry of the bright Swift gamma-ray burst (GRB) 080607, starting only 6 s following the initial trigger in the rest frame. Complemented by our previously published spectroscopy, this high-quality photometric data set allows us to solve for the extinction properties of the redshift 3.036 sightline, giving perhaps the most detailed information to date on the ultraviolet continuum absorption properties of any sightline outside our Local Group. The extinction properties are not adequately modeled by any ordinary extinction template (including the average Milky Way, Large Magellanic Cloud, and Small Magellanic Cloud curves), partially because themore » 2175 A feature (while present) is weaker by about a factor of two than when seen under similar circumstances locally. However, the spectral energy distribution is exquisitely fitted by the more general Fitzpatrick and Massa parameterization of Local-Group extinction, putting it in the same family as some peculiar Milky Way extinction curves. After correcting for this (considerable, A{sub V} = 3.3 {+-} 0.4 mag) extinction, GRB 080607 is revealed to have been among the most optically luminous events ever observed, comparable to the naked-eye burst GRB 080319B. Its early peak time (t{sub rest} < 6 s) indicates a high initial Lorentz factor ({Gamma}>600), while the extreme luminosity may be explained in part by a large circumburst density. Only because of its early high luminosity could the afterglow of GRB 080607 be studied in such detail in spite of the large attenuation and great distance, making this burst an excellent prototype for the understanding of other highly obscured extragalactic objects, and of the class of 'dark' GRBs in particular.« less

Search for TeV Gamma-ray Emission from GRB 100621A, an extremely bright GRB in X-rays, with H.E.S.S.

NASA Astrophysics Data System (ADS)

H.E.S.S. Collaboration; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Méhault, J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; O'Brien, P. T.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tam, P. H. T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Wagner, S. J.; Wagner, P.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

2014-05-01

The long gamma-ray burst (GRB) 100621A, at the time the brightest X-ray transient ever detected by Swift-XRT in the 0.3-10 keV range, has been observed with the H.E.S.S. imaging air Cherenkov telescope array, sensitive to gamma radiation in the very-high-energy (VHE, >100 GeV) regime. Due to its relatively small redshift of z ~ 0.5, the favourable position in the southern sky and the relatively short follow-up time (<700 s after the satellite trigger) of the H.E.S.S. observations, this GRB could be within the sensitivity reach of the H.E.S.S. instrument. The analysis of the H.E.S.S. data shows no indication of emission and yields an integral flux upper limit above ~380 GeV of 4.2 × 10-12 cm-2 s-1 (95% confidence level), assuming a simple Band function extension model. A comparison to a spectral-temporal model, normalised to the prompt flux at sub-MeV energies, constraints the existence of a temporally extended and strong additional hard power law, as has been observed in the other bright X-ray GRB 130427A. A comparison between the H.E.S.S. upper limit and the contemporaneous energy output in X-rays constrains the ratio between the X-ray and VHE gamma-ray fluxes to be greater than 0.4. This value is an important quantity for modelling the afterglow and can constrain leptonic emission scenarios, where leptons are responsible for the X-ray emission and might produce VHE gamma rays.

FERMI Observations of GRB 090902B: A Distinct Spectral Component in the Prompt and Delayed Emission

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2009-11-03

Here, we report on the observation of the bright, long gamma-ray burst (GRB), GRB 090902B, by the Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) instruments on-board the Fermi observatory. This was one of the brightest GRBs to have been observed by the LAT, which detected several hundred photons during the prompt phase. With a redshift of z = 1.822, this burst is among the most luminous detected by Fermi. Time-resolved spectral analysis reveals a significant power-law component in the LAT data that is distinct from the usual Band model emission that is seen in the sub-MeV energy range.more » This power-law component appears to extrapolate from the GeV range to the lowest energies and is more intense than the Band component, both below ~50 keV and above 100 MeV. The Band component undergoes substantial spectral evolution over the entire course of the burst, while the photon index of the power-law component remains constant for most of the prompt phase, then hardens significantly toward the end. After the prompt phase, power-law emission persists in the LAT data as late as 1 ks post-trigger, with its flux declining as t –1.5. The LAT detected a photon with the highest energy so far measured from a GRB, 33.4 +2.7 –3.5 GeV. This event arrived 82 s after the GBM trigger and ~50 s after the prompt phase emission had ended in the GBM band. In conclusion, we discuss the implications of these results for models of GRB emission and for constraints on models of the extragalactic background light.« less

A Temporal Correlation in Quiescent Gamma-Ray Burst Prompt Emission: Evidence for Prognitor Memory

NASA Astrophysics Data System (ADS)

Patton, Thomas L.; Giblin, Timothy; Hakkila, Jon E.

2018-06-01

In spite of the insight gained into the nature of the Gamma-Ray Bursts (GRB) from early and late-time X-Ray observations in the Swift era, GRB prompt emission continues to provide clues and new insight into the activity of the central engine. A comprehensive understanding of all emission components observed in GRBs, from the traditional prompt GRB emission to the long lived X-Ray and optical decay super- imposed with late-time flaring activity, currently remains allusive. Using data from the Swift Burst Alert Telescope (BAT), we've identified and measured durations observed in GRBs that exhibit multi-episodic prompt emission behavior. Duration analysis of the burst attributes revealed no significant correlations between emissions and quiet time durations. This variability allows us to extrapolate that the central engine is constantly active.

An Estimation of the Gamma-Ray Burst Afterglow Apparent Optical Brightness Distribution Function

NASA Astrophysics Data System (ADS)

Akerlof, Carl W.; Swan, Heather F.

2007-12-01

By using recent publicly available observational data obtained in conjunction with the NASA Swift gamma-ray burst (GRB) mission and a novel data analysis technique, we have been able to make some rough estimates of the GRB afterglow apparent optical brightness distribution function. The results suggest that 71% of all burst afterglows have optical magnitudes with mR<22.1 at 1000 s after the burst onset, the dimmest detected object in the data sample. There is a strong indication that the apparent optical magnitude distribution function peaks at mR~19.5. Such estimates may prove useful in guiding future plans to improve GRB counterpart observation programs. The employed numerical techniques might find application in a variety of other data analysis problems in which the intrinsic distributions must be inferred from a heterogeneous sample.

The Search for AGN in Dusty Star Forming Hosts with JWST

NASA Astrophysics Data System (ADS)

Kirkpatrick, Allison; Alberts, Stacey; Pope, Alexandra; Rieke, George; Sajina, Anna

2018-01-01

The bulk of the stellar growth over cosmic time is dominated by IR luminous galaxies at cosmic noon (z=1-2), many of which harbor a hidden active galactic nucleus (AGN). I use state of the art infrared color diagnostics, combining Spitzer and Herschel observations, to separate dust-obscured AGN from dusty star forming galaxies (SFGs) in the CANDELS and COSMOS surveys. I calculate 24 micron counts of SFGs, AGN/star forming "Composites", and AGN. AGN and Composites dominate the counts above 0.8 mJy at 24 micron, and Composites form at least 25% of an IR sample even to faint detection limits. I develop methods to use the Mid-Infrared Instrument (MIRI) on JWST to identify dust-obscured AGN and Composite galaxies from z~1-2. I demonstrate that MIRI color techniques can select AGN with lower Eddington ratios and higher specific SFRs than X-ray techniques alone. JWST/MIRI will enable critical steps forward in identifying and understanding dust-obscured AGN and the link to their host galaxies.

Confirmation and characterization of young planetary companions hidden in the HST NICMOS archive

NASA Astrophysics Data System (ADS)

Pueyo, Laurent

2013-10-01

We propose to conduct WFC3 high contrast observations of six faint planetary candidates orbiting young {1 to 100 Myrs} stars identified in archival HST NICMOS coronagraphic data as part of our team's program AR-12652. Such rare objects are of the utmost importance to comparative exo-planetology as their physical properties reflect the initial conditions of still poorly constrained planetary formation mechanisms. Moreover directly imaged systems are precious artifacts in the expanding exo-planetary treasure trove as they are readily available for spectroscopic characterization. Our statistical analysis, which combines population synthesis models and empirical inspections of the entire NICMOS field of view for all sources observed in coronaraphic mode, almost guarantees that one of these six faint candidates is associated with its putative host star. We will conduct our observation in four near infrared filter, F125W, F160W to establish the baseline luminosity of our candidates and in F127M and F139M in order to probe the depth their water absorption features, characteristic of substellar /exo-planetary like atmospheres. Because of the youth of our targets, this program, which only requires a modest 12 HST orbits, will almost certainly identify and image a young or adolescent exo-planet.

The GRB All-sky Spectrometer Experiment II: Data Collection and Analysis

NASA Astrophysics Data System (ADS)

Voigt, Elana; Martinot, Zachary; Banks, Zachary; Pober, Jonathan; Morales, Miguel F.

2015-01-01

The GRB All-sky Spectrometer Experiment (GASE) is a widefield interferometer radio telescope designed to look for Gamma Ray Bursts in the 30 to 50 MHz range. It is based and operated as a wholly undergraduate experiment at the University of Washington. This poster will focus on data analysis and the relation of data analysis to the commissioning process of our 8 element GASE array.

Triggered and Untriggered Searches for GRB Optical Bursts with ROTSE

NASA Astrophysics Data System (ADS)

Kehoe, R.; Akerlof, C.; Lee, B.; McKay, T.; Rykoff, E.; Marshall, S.; Bloch, J.; Casperson, D.; Gisler, G.; Szymanski, J.; Wren, J.

2000-12-01

The ROTSE project is dedicated to the observation of early optical emission from gamma-ray bursts. We have pursued this goal both by analysis of data taken from satellite-derived triggers via GCN, as well as through the study of untriggered data. Recent work now permits us to analyze much larger fields than previously possible. We will discuss our searches for GRB optical bursts which utilize this capability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valle, Massimo Della; International Center for Relativistic Astrophysics Network, Piazzale della Repubblica 10, I-65122, Pescara

I’ll review the status of the Supernova/Gamma-Ray Burst connection. Several pieces of evidence suggest that long duration Gamma-ray Bursts are associated with bright SNe-Ic. However recent works suggest that GRBs might be produced in tight binary systems composed of a massive carbon-oxygen cores and a neutron star companion. Current estimates of the SN and GRB rates yield a ratio GRB/SNe-Ibc in the range ∼ 0.4% − 3%.

Gamma--Ray burst afterglows with the Watcher robotic telescope

NASA Astrophysics Data System (ADS)

Topinka, M.; Hanlon, L.; Meehan, S.; Tisdall, P.; Jelínek, M.; Kubánek, P.; van Heerden, H.; Meintjes, P.

2014-12-01

The main scientific goal of the Watcher robotic telescope is the rapid follow-up observation of gamma--ray burst afterglows. Some examples of recent observations, including GRB 120327A and GRB 130606A, at a redshift of 5.9, are presented. The telescope has recently been successfully integrated into the GLORIA global robotic telescope network, which allows users to use the array for their own scientific projects.

Possible Detection of Gamma Ray Air Showers in Coincidence with BATSE Gamma Ray Bursts

NASA Astrophysics Data System (ADS)

Lin, Tzu-Fen

1999-08-01

Project GRAND presents the results of a search for coincident high-energy gamma ray events in the direction and at the time of nine Gamma Ray Bursts (GRBs) detected by BATSE. A gamma ray has a non-negligible hadron production cross section; for each gamma ray of energy of 100 GeV, there are 0.015 muons which reach detection level (Fasso & Poirier, 1999). These muons are identified and their angles are measured in stations of eight planes of proportional wire chambers (PWCs). A 50 mm steel plate above the bottom pair of planes is used to distinguish muons from electrons. The mean angular resolution is 0.26o over a ± 61o range in the XZ and YZ planes. The BATSE GRB catalogue is examined for bursts which are near zenith for Project GRAND. The geometrical acceptance is calculated for each of these events. The product is then taken of the GRB flux and GRANDÕs geometrical acceptance. The nine sources with the best combination of detection efficiency and BATSEÕs intensity are selected to be examined in the data. The most significant detection of these nine sources is at a statistical significance of +3.7s; this is also the GRB with the highest product of GRB flux and geometrical acceptance.

The Signature of the Central Engine in the Weakest Relativistic Explosions: GRB 100316D

NASA Astrophysics Data System (ADS)

Margutti, R.; Soderberg, A. M.; Wieringa, M. H.; Edwards, P. G.; Chevalier, R. A.; Morsony, B. J.; Barniol Duran, R.; Sironi, L.; Zauderer, B. A.; Milisavljevic, D.; Kamble, A.; Pian, E.

2013-11-01

We present late-time radio and X-ray observations of the nearby sub-energetic gamma-ray burst (GRB)100316D associated with supernova (SN) 2010bh. Our broad-band analysis constrains the explosion properties of GRB 100316D to be intermediate between highly relativistic, collimated GRBs and the spherical, ordinary hydrogen-stripped SNe. We find that ~1049 erg is coupled to mildly relativistic (Γ = 1.5-2), quasi-spherical ejecta, expanding into a medium previously shaped by the progenitor mass-loss with a rate of \\dot{M}\\, {\\sim }\\, 10^{-5}\\,M_{\\odot }\\,yr^{-1} (for an assumed wind density profile and wind velocity vw = 1000 km s-1). The kinetic energy profile of the ejecta argues for the presence of a central engine and identifies GRB 100316D as one of the weakest central-engine-driven explosions detected to date. Emission from the central engine is responsible for an excess of soft X-ray radiation that dominates over the standard afterglow at late times (t > 10 days). We connect this phenomenology with the birth of the most rapidly rotating magnetars. Alternatively, accretion onto a newly formed black hole might explain the excess of radiation. However, significant departure from the standard fall-back scenario is required.

UNCOVERING THE INTRINSIC VARIABILITY OF GAMMA-RAY BURSTS

NASA Astrophysics Data System (ADS)

Golkhou, V. Zach; Butler, Nathaniel R

2014-08-01

We develop a robust technique to determine the minimum variability timescale for gamma-ray burst (GRB) light curves, utilizing Haar wavelets. Our approach averages over the data for a given GRB, providing an aggregate measure of signal variation while also retaining sensitivity to narrow pulses within complicated time series. In contrast to previous studies using wavelets, which simply define the minimum timescale in reference to the measurement noise floor, our approach identifies the signature of temporally smooth features in the wavelet scaleogram and then additionally identifies a break in the scaleogram on longer timescales as a signature of a true, temporally unsmooth light curve feature or features. We apply our technique to the large sample of Swift GRB gamma-ray light curves and for the first time—due to the presence of a large number of GRBs with measured redshift—determine the distribution of minimum variability timescales in the source frame. We find a median minimum timescale for long-duration GRBs in the source frame of Δtmin = 0.5 s, with the shortest timescale found being on the order of 10 ms. This short timescale suggests a compact central engine (3000 km). We discuss further implications for the GRB fireball model and present a tantalizing correlation between the minimum timescale and redshift, which may in part be due to cosmological time dilation.

Multiwavelength Observations of GRB 110731A: GeV Emission From Onset to Afterglow

DOE PAGES

Ackermann, M.; Ajello, M.; Asano, K.; ...

2013-01-09

In this paper, we report on the multiwavelength observations of the bright, long gamma-ray burst GRB 110731A, by the Fermi and Swift observatories, and by the MOA and GROND optical telescopes. The analysis of the prompt phase reveals that GRB 110731A shares many features with bright Large Area Telescope bursts observed by Fermi during the first three years on-orbit: a light curve with short time variability across the whole energy range during the prompt phase, delayed onset of the emission above 100 MeV, extra power-law component and temporally extended high-energy emission. In addition, this is the first GRB for whichmore » simultaneous GeV, X-ray, and optical data are available over multiple epochs beginning just after the trigger time and extending for more than 800 s, allowing temporal and spectral analysis in different epochs that favor emission from the forward shock in a wind-type medium. Lastly, the observed temporally extended GeV emission is most likely part of the high-energy end of the afterglow emission. Both the single-zone pair transparency constraint for the prompt signal and the spectral and temporal analysis of the forward-shock afterglow emission independently lead to an estimate of the bulk Lorentz factor of the jet Γ ~ 500-550.« less

Multiwavelength Observations of GRB 110731A: GeV Emission from Onset to Afterglow

NASA Astrophysics Data System (ADS)

Ackermann, M.; Ajello, M.; Asano, K.; Baldini, L.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Bellazzini, R.; Blandford, R. D.; Bonamente, E.; Borgland, A. W.; Bottacini, E.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cecchi, C.; Charles, E.; Chaves, R. C. G.; Chekhtman, A.; Chiang, J.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Silva, E. do Couto e.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Fegan, S. J.; Focke, W. B.; Franckowiak, A.; Fukazawa, Y.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Granot, J.; Greiner, J.; Grenier, I. A.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hanabata, Y.; Hayashida, M.; Hays, E.; Hughes, R. E.; Jackson, M. S.; Jogler, T.; Jóhannesson, G.; Johnson, A. S.; Knödlseder, J.; Kocevski, D.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Mazziotta, M. N.; McEnery, J. E.; Mehault, J.; Mészáros, P.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Moretti, E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Naumann-Godo, M.; Norris, J. P.; Nuss, E.; Nymark, T.; Ohno, M.; Ohsugi, T.; Omodei, N.; Orienti, M.; Orlando, E.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Racusin, J. L.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Romoli, C.; Roth, M.; Ryde, F.; Sanchez, D. A.; Sgrò, C.; Siskind, E. J.; Sonbas, E.; Spinelli, P.; Stamatikos, M.; Takahashi, H.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Tibaldo, L.; Tinivella, M.; Tosti, G.; Troja, E.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Winer, B. L.; Wood, K. S.; Yang, Z.; Gruber, D.; Bhat, P. N.; Bissaldi, E.; Briggs, M. S.; Burgess, J. M.; Connaughton, V.; Foley, S.; Kippen, R. M.; Kouveliotou, C.; McBreen, S.; McGlynn, S.; Paciesas, W. S.; Pelassa, V.; Preece, R.; Rau, A.; van der Horst, A. J.; von Kienlin, A.; Kann, D. A.; Filgas, R.; Klose, S.; Krühler, T.; Fukui, A.; Sako, T.; Tristram, P. J.; Oates, S. R.; Ukwatta, T. N.; Littlejohns, O.

2013-02-01

We report on the multiwavelength observations of the bright, long gamma-ray burst GRB 110731A, by the Fermi and Swift observatories, and by the MOA and GROND optical telescopes. The analysis of the prompt phase reveals that GRB 110731A shares many features with bright Large Area Telescope bursts observed by Fermi during the first three years on-orbit: a light curve with short time variability across the whole energy range during the prompt phase, delayed onset of the emission above 100 MeV, extra power-law component and temporally extended high-energy emission. In addition, this is the first GRB for which simultaneous GeV, X-ray, and optical data are available over multiple epochs beginning just after the trigger time and extending for more than 800 s, allowing temporal and spectral analysis in different epochs that favor emission from the forward shock in a wind-type medium. The observed temporally extended GeV emission is most likely part of the high-energy end of the afterglow emission. Both the single-zone pair transparency constraint for the prompt signal and the spectral and temporal analysis of the forward-shock afterglow emission independently lead to an estimate of the bulk Lorentz factor of the jet Γ ~ 500-550.

Evaluating the Bulk Lorentz Factors of Outflow Material: Lessons Learned from the Extremely Energetic Outburst GRB 160625B

NASA Astrophysics Data System (ADS)

Wang, Yuan-Zhu; Wang, Hao; Zhang, Shuai; Liang, Yun-Feng; Jin, Zhi-Ping; He, Hao-Ning; Liao, Neng-Hui; Fan, Yi-Zhong; Wei, Da-Ming

2017-02-01

GRB 160625B is an extremely bright outburst with well-monitored afterglow emission. The geometry-corrected energy is high, up to ˜5.2 × 1052 erg or even ˜8 × 1052 erg, rendering it the most energetic GRB prompt emission recorded so far. We analyzed the time-resolved spectra of the prompt emission and found that in some intervals there were likely thermal-radiation components and the high energy emission was characterized by significant cutoff. The bulk Lorentz factors of the outflow material are estimated accordingly. We found out that the Lorentz factors derived in the thermal-radiation model are consistent with the luminosity-Lorentz factor correlation found in other bursts, as well as in GRB 090902B for the time-resolved thermal-radiation components, while the spectral cutoff model yields much lower Lorentz factors that are in tension with the constraints set by the electron pair Compton scattering process. We then suggest that these spectral cutoffs are more likely related to the particle acceleration process and that one should be careful in estimating the Lorentz factors if the spectrum cuts at a rather low energy (e.g., ˜tens of MeV). The nature of the central engine has also been discussed, and a stellar-mass black hole is favored.