78 FR 37963 - Safety Zone; Fifth Coast Guard District Fireworks Display Cape Fear River; Wilmington, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

...-AA00 Safety Zone; Fifth Coast Guard District Fireworks Display Cape Fear River; Wilmington, NC AGENCY... District. This regulation applies to only one recurring fireworks event, held adjacent to the Cape Fear... of the Cape Fear River, Wilmington, North Carolina, during the event. DATES: This rule will be...

77 FR 44468 - Safety Zone; Fireworks for NC NENA/APCO Conference, Cape Fear River; Wilmington, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... 1625-AA00 Safety Zone; Fireworks for NC NENA/APCO Conference, Cape Fear River; Wilmington, NC AGENCY... on the navigable waters of Cape Fear River; Wilmington, NC in support of the Fireworks display for... shore of the Cape Fear River at Battleship Park. The fireworks debris fallout area will extend over the...

75 FR 52461 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway, Wrightsville Beach, NC and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-26

... Operation Regulation; Atlantic Intracoastal Waterway, Wrightsville Beach, NC and Northeast Cape Fear River... Bridge across the Northeast Cape Fear River, mile 1.0, at Wilmington, NC. The deviation is necessary to.... Holmes Bridge across the Northeast Cape Fear River, mile 1.0, at Wilmington. The current operating...

33 CFR 167.250 - In the approaches to the Cape Fear River: General.

Code of Federal Regulations, 2012 CFR

2012-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.250 In the approaches to the Cape Fear River: General. The traffic separation scheme (TSS) in the approaches to the Cape Fear River...

33 CFR 167.250 - In the approaches to the Cape Fear River: General.

Code of Federal Regulations, 2013 CFR

2013-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.250 In the approaches to the Cape Fear River: General. The traffic separation scheme (TSS) in the approaches to the Cape Fear River...

33 CFR 167.250 - In the approaches to the Cape Fear River: General.

Code of Federal Regulations, 2011 CFR

2011-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.250 In the approaches to the Cape Fear River: General. The traffic separation scheme (TSS) in the approaches to the Cape Fear River...

33 CFR 167.250 - In the approaches to the Cape Fear River: General.

Code of Federal Regulations, 2014 CFR

2014-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.250 In the approaches to the Cape Fear River: General. The traffic separation scheme (TSS) in the approaches to the Cape Fear River...

33 CFR 167.252 - In the approaches to the Cape Fear River: Traffic separation scheme.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Fear River: Traffic separation scheme. 167.252 Section 167.252 Navigation and Navigable Waters COAST... SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.252 In the approaches to the Cape Fear River: Traffic separation scheme. (a) A traffic separation...

33 CFR 167.252 - In the approaches to the Cape Fear River: Traffic separation scheme.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Fear River: Traffic separation scheme. 167.252 Section 167.252 Navigation and Navigable Waters COAST... SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.252 In the approaches to the Cape Fear River: Traffic separation scheme. (a) A traffic separation...

33 CFR 167.252 - In the approaches to the Cape Fear River: Traffic separation scheme.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Fear River: Traffic separation scheme. 167.252 Section 167.252 Navigation and Navigable Waters COAST... SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.252 In the approaches to the Cape Fear River: Traffic separation scheme. (a) A traffic separation...

33 CFR 167.252 - In the approaches to the Cape Fear River: Traffic separation scheme.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Fear River: Traffic separation scheme. 167.252 Section 167.252 Navigation and Navigable Waters COAST... SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.252 In the approaches to the Cape Fear River: Traffic separation scheme. (a) A traffic separation...

Triggering mechanism and tsunamogenic potential of the Cape Fear Slide complex, U.S. Atlantic margin

USGS Publications Warehouse

Hornbach, Matthew J.; Lavier, Luc L.; Ruppel, Carolyn D.

2007-01-01

Analysis of new multibeam bathymetry data and seismic Chirp data acquired over the Cape Fear Slide complex on the U.S. Atlantic margin suggests that at least 5 major submarine slides have likely occurred there within the past 30,000 years, indicating that repetitive, large-scale mass wasting and associated tsunamis may be more common in this area than previously believed. Gas hydrate deposits and associated free gas as well as salt tectonics have been implicated in previous studies as triggers for the major Cape Fear slide events. Analysis of the interaction of the gas hydrate phase boundary and the various generations of slides indicates that only the most landward slide likely intersected the phase boundary and inferred high gas pressures below it. For much of the region, we believe that displacement along a newly recognized normal fault led to upward migration of salt, oversteepening of slopes, and repeated slope failures. Using new constraints on slide morphology, we develop the first tsunami model for the Cape Fear Slide complex. Our results indicate that if the most seaward Cape Fear slide event occurred today, it could produce waves in excess of 2 m at the present-day 100 m bathymetric contour.

77 FR 51699 - Drawbridge Operation Regulation; Cape Fear River, Wilmington, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... Operation Regulation; Cape Fear River, Wilmington, NC AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The Commander, Fifth Coast Guard District, has issued a temporary [[Page 51700

A predictive risk model for electroshock-induced mortality of the endangered Cape Fear shiner

USGS Publications Warehouse

Holliman, F.M.; Reynolds, J.B.; Kwak, T.J.

2003-01-01

We evaluated the effects of a single electroshock on injury and mortality of hatchery-reared Cape Fear shiners Notropis mekistocholas (N = 517), an endangered cyprinid. Groups of 18-22 Cape Fear shiners were exposed to DC, 120-Hz pulsed DC (PDC), or 60-Hz PDC at voltage gradients of 1.1, 1.9, or 2.7 V/cm for 3 s. Mortality occurred only among fish exposed to 120-Hz PDC (25%) and DC (38%) applied at 2.7 V/cm. Because no mortality occurred in Cape Fear shiners exposed to 60-Hz PDC, this waveform was selected for further study of electroshock duration (3, 6, 12, 24, or 48 s) and voltage gradient (0.9, 1.6, or 2.3 V/cm). Most fish electroshocked in the experiments were immobilized (ceased swimming motion). No physical injury was detected by necropsy or radiography in any fish. Electroshock-induced mortality of Cape Fear shiners showed a strong multivariable relationship to voltage gradient, electroshock duration, and fish length. Fish subjected to 60-Hz PDC at 0.9 or 1.6 V/cm for 6 s experienced low mortality (<10%). Our results demonstrate that Cape Fear shiners can be immobilized by 60-Hz PDC electroshock without injury or significant risk of mortality. We propose that electrofishing may be safely used to sample similar small cyprinids, imperiled or otherwise, when electrofishers select an appropriate waveform (DC pulsed at 60-Hz or less) and use it judiciously (minimal exposure at, or below, the immobilization threshold).

33 CFR 165.540 - Regulated Navigation Area; Cape Fear River, Northeast Cape Fear River, Wilmington, North Carolina.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Carolina Power & Light Company (CP&L) overhead power line crossing). (4) Passing Lane and Anchorage Basin... Buoy 56 (LL 30830) and approximately 590 feet downstream of the CP&L overhead power line crossing...

33 CFR 165.540 - Regulated Navigation Area; Cape Fear River, Northeast Cape Fear River, Wilmington, North Carolina.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Carolina Power & Light Company (CP&L) overhead power line crossing). (4) Passing Lane and Anchorage Basin... Buoy 56 (LL 30830) and approximately 590 feet downstream of the CP&L overhead power line crossing...

33 CFR 165.540 - Regulated Navigation Area; Cape Fear River, Northeast Cape Fear River, Wilmington, North Carolina.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Carolina Power & Light Company (CP&L) overhead power line crossing). (4) Passing Lane and Anchorage Basin... Buoy 56 (LL 30830) and approximately 590 feet downstream of the CP&L overhead power line crossing...

33 CFR 165.540 - Regulated Navigation Area; Cape Fear River, Northeast Cape Fear River, Wilmington, North Carolina.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Carolina Power & Light Company (CP&L) overhead power line crossing). (4) Passing Lane and Anchorage Basin... Buoy 56 (LL 30830) and approximately 590 feet downstream of the CP&L overhead power line crossing...

33 CFR 165.540 - Regulated Navigation Area; Cape Fear River, Northeast Cape Fear River, Wilmington, North Carolina.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Carolina Power & Light Company (CP&L) overhead power line crossing). (4) Passing Lane and Anchorage Basin... Buoy 56 (LL 30830) and approximately 590 feet downstream of the CP&L overhead power line crossing...

CNC Preparation Meets Manufacturing Opportunity

ERIC Educational Resources Information Center

Cassola, Joel

2006-01-01

This article features the machining technology program at Cape Fear Community College (CFCC) of Wilmington, North Carolina. North Carolina's Cape Fear Community College is working to meet diverse industry needs through its CNC training. The school's program has gained the attention of the local manufacturing community and students when it shifted…

The Cape Fear Plan.

ERIC Educational Resources Information Center

Conrath, Richard C.

In spring 1992, Cape Fear Community College (CFCC) completed its long-range strategic plan. The consultant who helped guide the institution through the process presented the plan to the Board of Trustees with 60 recommendations for implementation. The Chairman of the Board established task forces to study the recommendations for each major…

Potentiometric surface of the lower Cape Fear Aquifer in the central coastal plain of North Carolina, December 1986

USGS Publications Warehouse

Winner, M.D.; Lyke, William L.; Brockman, Allen R.

1989-01-01

Water level measurements were made in four wells open to the lower Cape Fear aquifer at the end of 1986 to determine the configuration of its potentiometric surface over an area of approximately 4,100 sq mi. Because of the scarcity of data, five earlier measurements were also used to help estimate the position of the potentiometric contours. These were one-time measurements in temporary observation wells. A broad cone of depression has formed in the area between Kinston and New Bern where the potentiometric surface is below sea level and seems likely related to large groundwater withdrawals from the aquifers overlying the lower Cape Fear in that area.

Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina

EPA Science Inventory

Long-chain per- and polyfluoroalkyl substances (PFASs) are being replaced by short-chain PFASs and fluorinated alternatives. For ten legacy PFASs and seven recently discovered perfluoroalkyl ether carboxylic acids (PFECAs), we report (1) their occurrence in the Cape Fear River (C...

Applications of ichnology to hydrogeology, with examples from the Cape Fear Formation (Cretaceous), South Carolina

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, A.J.; Simones, G.C.

Ichnology, the study of modern and ancient traces left by organisms, has provided supplemental information to geologic subdisciplines such as sedimentology and stratigraphy. The major objective of the authors paper is to emphasize the valuable information that can be conveyed by trace fossils in the investigation of hydrogeologic units. Bioturbation has a net effect of mixing different types and layers of sediments, such as introducing clays into sands and vice versa. This mixing can decrease porosity and permeability of sandy units, thus changing potential aquifers into confining units. For example, a sandy fluvial deposit will contain distinctive nonmarine trace fossils,more » thus defining channel sands that may serve as permeable conduits for ground-water flow. In contrast, a sandy shelf deposit will contain marine trace fossils in a sand body geometry that will be markedly different from aquifers produced in nonmarine environments. Bioturbation also causes geochemical and diagenetic changes in sediments, causing irrigation of previously anoxic sediments and precipitation of ion oxides. The Cretaceous Cape Fear Formation of the Atlantic Coastal Plain, in the subsurface of South Carolina, is presented as an example of a hydrogeologic unit that has been reinterpreted using ichnologic data. Extensive bioturbation caused mixing of clays and sands in Cape Fear sediments, which resulted in the Cape Fear becoming a regional confining system. Trace fossil assemblages indicate a brackish water environment, perhaps estuarine, for the Cape Fear, as opposed to previous interpretations of fluvial and deltaic environments. Bioturbated zones also have significantly more oxidized iron than unbioturbated zones, highlighting potential effects on ground-water quality.« less

Ground-water level data for North Carolina, 1987

USGS Publications Warehouse

Coble, Ronald W.; Strickland, A.G.; Bailey, M. Carl

1989-01-01

Continuous and periodic measurements in 54 key wells and water-level measurements emplaced in Coastal Plain aquifers across North Carolina in 193 supplemental wells are presented in this report. Hydrographs of selected wells show changes in ground-water storage in the State. The water table in the shallow aquifers was higher throughout most of the State in 1987 than in 1986, indicating that rain had recharged these aquifers sufficiently to replenish the deficit in ground water storage that accumulated in the western and central parts of the State during 1986. Water levels in the heavily pumped Coastal Plain aquifers show a general downward trend for the year, indicating ground water is being withdrawn from aquifer storage. Record low water levels were measured in 4 of 13 wells in the Castle Hayne aquifer; the greatest decline measured during 1987 was 0.3 ft. Water levels in wells in the Peedee, Black Creek, upper Cape Fear, and lower Cape Fear aquifers generally show downward trends. Record low water levels were measured in 4 of 8 wells in the Peedee aquifer; the maximum decline measured during 1987 was 1.5 ft. All wells in the Black Creek, upper Cape Fear, and lower Cape Fear aquifers had record low water levels for 1987, with maximum measured declines in 1987 of 8.6, 3.1, and 3.1 ft., respectively. Record high water levels were measured in two wells, one each in the Castle Hayne and Peedee aquifers. Potentiometric surface maps show the effects of major centers of pumping for the Castle Hayne, Black Creek, and lower Cape Fear aquifers of the Coastal Plain.

75 FR 53264 - Restricted Area in Cape Fear River and Tributaries at Sunny Point Army Terminal, Brunswick County...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... DEPARTMENT OF DEFENSE Department of the Army, Corps of Engineers 33 CFR Part 334 Restricted Area in Cape Fear River and Tributaries at Sunny Point Army Terminal, Brunswick County, NC AGENCY: U.S. Army Corps of Engineers, DoD. ACTION: Proposed rule. SUMMARY: The U.S. Army requested that the U.S...

75 FR 53197 - Restricted Area in Cape Fear River and Tributaries at Sunny Point Army Terminal, Brunswick County...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... DEPARTMENT OF DEFENSE Department of the Army, Corps of Engineers 33 CFR Part 334 Restricted Area in Cape Fear River and Tributaries at Sunny Point Army Terminal, Brunswick County, NC AGENCY: U.S. Army Corps of Engineers, DoD. ACTION: Direct final rule. SUMMARY: The U.S. Army requested that the U.S...

Stress history and geotechnical properties of sediment from the Cape Fear Diapir, Blake Ridge Diapir, and Blake Ridge

USGS Publications Warehouse

Winters, W.J.

2000-01-01

Geotechnical properties of sediment from Ocean Drilling Program Leg 164 are presented as: (1) normalized shipboard strength ratios from the Cape Fear Diapir, the Blake Ridge Diapir, and the Blake Ridge; and (2) Atterberg limit, vane shear strength, pocket-penetrometer strength, and constant-rate-of-strain consolidation results from Hole 995A, located on the Blake Ridge. This study was conducted to understand the stress history in a region characterized by high sedimentation rates and the presence of gas hydrates. Collectively, the results indicate that sediment from the Blake Ridge exhibits significant underconsolidated behavior, except near the seafloor. At least 10 m of additional overburden was removed by erosion or mass wasting at Hole 993A on the Cape Fear Diapir, compared to nearby sites.

77 FR 37324 - Safety Zone; Major Motion Picture Filming, Cape Fear River; Wilmington, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... vessels from a portion of the Cape Fear River due to the filming of a movie involving high speed boat..., given the high risks of injury and damage that will be created during the filming of the movie, a delay...; 46 U.S.C. Chapter 701, 3306, 3703; 50 U.S.C. 191, 195; 33 CFR 1.05-1, 6.04-1, 6.04-6, 160.5; Pub. L...

Evidence for gas accumulation associated with diapirism and gas hydrates at the head of the Cape Fear Slide

USGS Publications Warehouse

Schmuck, E.A.; Paull, C.K.

1993-01-01

Single-channel seismic reflection profiles show evidence for areas of significant gas accumulation at the head of the Cape Fear Slide on the continental rise oft North Carolina. Gas accumulation appears to occur beneath a gas hydrate seal in landward-dipping strata and in domed strata associated with diapirism. In addition, gas venting may have occurred near diapirs located at the head of the slide.

Evidence for gas accumulation associated with diapirism and gas hydrates at the head of the Cape Fear Slide

USGS Publications Warehouse

Schmuck, E.A.; Paull, C.K.

1993-01-01

Single-channel seismic reflection profiles show evidence for areas of significant gas accumulation at the head of the Cape Fear Slide on the continental rise off North Carolina. Gas accumulation appears to occur beneath a gas hydrate seal in landward-dipping strata and in domed strata associated with diapirism. In addition, gas venting may have occurred near diapirs located at the head of the slide. ?? 1993 Springer-Verlag.

Water quality of North Carolina streams; water-quality characteristics for selected sites on the Cape Fear River, North Carolina, 1955-1980; variability, loads, and trends of selected constituents

USGS Publications Warehouse

Crawford, J. Kent

1985-01-01

Historical water-quality data collected by the U.S. Geological Survey from the Cape Fear River at Lock 1, near Kelly, North Carolina, show increasing concentrations of total-dissolved solids, specific conductance, sulfate, chloride, nitrite plus nitrate nitrogen, magnesium, sodium, and potassium during the past 25 years. Silica and pH show decreasing trends during the same 1957-80 period. These long-term changes in water quality are statistically related to increasing population in the basin and especially to manufacturing employment. Comparisons of water-quality data for present conditions with estimated natural conditions indicate that over 50 percent of the loads of most major dissolved substances in the river at Lock 1 are the result of development impacts in the basin. Over 80 percent of the nutrients plus nitrate nitrogen, ammonia nitrogen, and total phosphorus presently in the streams originate from development. At four sampling stations on the Cape Fear River and its tributaries, recent water-quality data show that most constituents are always within North Carolina water-quality standards and Environmental Protection Agency water-quality criteria. However, iron, manganese and mercury concentrations usually exceed standards. Although no algal problems have been identified in the Cape Fear River, nitrogen and phosphorus are present in concentrations that have produced nuisance algal growths in lakes

75 FR 11862 - Endangered Species; File No. 14759

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... Fear) and estuaries (Albemarle Sound) using non-lethal sampling methods combining hydroacoustic surveys..., Neuse, Cape Fear river systems and Albemarle Sound, and up to 20 shortnose sturgeon from the Roanoke...

Water-level conditions in the upper Cape Fear Aquifer, 1994-98, in parts of Bladen and Robeson counties, North Carolina

USGS Publications Warehouse

Strickland, A.G.

1999-01-01

Water-level measurements were made on a periodic basis from October 1994 through November 1998 in 17 wells that tap the upper Cape Fear aquifer. The approximately 730-square-mile study area in Bladen and Robeson Counties is in the southern Coastal Plain of North Carolina. Water-level declines occurred in the aquifer throughout much of the area as a result of pumping during this period. The greatest decline was about 42 feet in Bladen County. Water levels from the wells in the fall of 1998 were used to construct a map of the potentiometric surface of the upper Cape Fear aquifer. This map can be used to infer the direction of ground-water movement in the aquifer. Withdrawals from wells at pumping centers, such as in the Tar Heel and Elizabethtown areas in Bladen County, have caused ground water to flow toward pumped wells, resulting in cones of depression in the potentiometric surface.

Hydrogeology and Ground-Water Quality of Brunswick County, North Carolina

USGS Publications Warehouse

Harden, Stephen L.; Fine, Jason M.; Spruill, Timothy B.

2003-01-01

Brunswick County is the southernmost coastal county in North Carolina and lies in the southeastern part of the Coastal Plain physiographic province. In this report, geologic, hydrologic, and chemical data were used to investigate and delineate the hydrogeologic framework and ground-water quality of Brunswick County. The major aquifers and their associated confining units delineated in the Brunswick County study area include, from youngest to oldest, the surficial, Castle Hayne, Peedee, Black Creek, upper Cape Fear, and lower Cape Fear aquifers.All of these aquifers, with the exception of the Castle Hayne aquifer, are located throughout Brunswick County. The Castle Hayne aquifer extends across only the southeastern part of the county. Based on available data, the Castle Hayne and Peedee confining units are missing in some areas of Brunswick County, which allows direct hydraulic contact between the surficial aquifer and underlying Castle Hayne or Peedee aquifers. The confining units for the Black Creek, upper Cape Fear, and lower Cape Fear aquifers appear to be continuous throughout Brunswick County.In examining the conceptual hydrologic system for Brunswick County, a generalized water budget was developed to better understand the natural processes, including precipitation, evapotranspiration, and stream runoff, that influence ground-water recharge to the shallow aquifer system in the county. In the generalized water budget, an estimated 11 inches per year of the average annual precipitation of 55 inches per year in Brunswick County is estimated to infiltrate and recharge the shallow aquifer system. Of the 11 inches per year that recharges the shallow system, about 1 inch per year is estimated to recharge the deeper aquifer system.The surficial aquifer in Brunswick County is an important source of water for domestic supply and irrigation. The Castle Hayne aquifer is the most productive aquifer and serves as the principal ground-water source of municipal supply for the county. The upper part of the Peedee aquifer is an important source of ground-water supply for domestic and commercial use. Ground water in the lower part of the Peedee aquifer and the underlying aquifers is brackish and is not known to be used as a source of supply in Brunswick County. Most of the precipitation that recharges the surficial aquifer is discharged to local streams that drain into the Waccamaw River, Cape Fear River, and Atlantic Ocean. Recharge to the Castle Hayne aquifer occurs primarily from the surficial aquifer. Recharge to the Peedee aquifer occurs primarily from the surficial and Castle Hayne aquifers, with some upward leakage of water also occurring from the underlying Black Creek aquifer. Discharge from the Castle Hayne and Peedee aquifers occurs to local streams, the Cape Fear River, and the Atlantic Ocean.Evaluation of water-level data for the period January 1970 through May 2002 indicated no apparent long-term temporal trends in water levels in the surficial and Castle Hayne aquifers and in the upper part of the Peedee aquifer. The most significant water-level trends were noted for wells tapping the lower part of the Peedee aquifer and tapping the Black Creek aquifer where water levels have declined as much as 41 and 37 feet, respectively. These ground-water-level declines are attributed to regional ground-water pumping in areas outside of Brunswick County. Water-level data for Brunswick County wells tapping the upper Cape Fear and lower Cape Fear aquifers tend to fluctuate within a fairly uniform range with no apparent temporal trend noted. Analysis of vertical hydraulic gradients during this same period primarily indicate downward flow of ground water within and among the surficial, Castle Hayne, and Peedee aquifers. The vertical flow of ground water in the Black Creek aquifer is upward into the overlying Peedee aquifer. Upward flow also is noted for the upper and lower Cape Fear aquifers.Historic and recent analytic data were evaluated to better understand the sources of water contained in Brunswick County aquifers and the suitability of the water for consumption. Based on analytical results obtained for recent samples collected during this study, ground water from the surficial aquifer, Castle Hayne aquifer, and upper part of the Peedee aquifer appears to be generally suitable for drinking water. Although concentrations of iron and manganese commonly exceeded the drinking-water standards, the concern generally associated with the occurrence of these analytes in a water supply is one of aesthetics. In all samples, nitrate, nitrite, and sulfate were detected at concentrations less than drinkingwater standards.Based on historic analytical data, the brackish water in the lower part of the Peedee aquifer and in the Black Creek, upper Cape Fear, and lower Cape Fear aquifers is classified as a sodium-chloride type water. The presence of brackish water in these deeper systems combined with upward vertical gradients presents the potential for upward migration of brackish water into overlying aquifers, or upconing beneath areas of pumping. The current (2001) location of the boundary between freshwater and brackish water in Brunswick County aquifers is unknown.

Hydrogeologic framework of the North Carolina Coastal Plain aquifer system

USGS Publications Warehouse

Winner, M.D.; Coble, R.W.

1989-01-01

The hydrogeologic framework of the North Carolina Coastal Plain aquifer system consists of ten aquifers separated by nine confining units. From top to bottom the aquifers are: the surficial aquifer, Yorktown aquifer, Pungo River aquifer, Castle Hayne aquifer, Beaufort aquifer, Peedee aquifer, Black Creek aquifer, upper Cape Fear aquifer, lower Cape Fear aquifer, and the Lower Cretaceous aquifer. The uppermost aquifer (the surficial aquifer in most places) is a water-table aquifer and the bottom of the system is underlain by crystalline bedrock. The sedimentary deposits forming the aquifers are of Holocene to Cretaceous age and are composed mostly of sand with lesser amounts of gravel and limestone. Confining units between aquifers are composed primarily of clay and silt. The thickness of the aquifers ranges from zero along the Fall Line to more than 10,000 feet at Cape Hatteras. Prominent structural features are the increasing easterly homoclinal dip of the sediments and the Cape Fear arch, the axis of which trends in a southeast direction. The stratigraphic continuity is determined from correlations of 161 geophysical logs along with data from drillers' and geologists' logs. Aquifers were defined by means of these logs plus water-level and water-quality data and evidence of the continuity of pumping effects. Eighteen hydrogeologic sections depict the correlation of these aquifers throughout the Coastal Plain.

Impact of hurricanes on the flux of rainwater and Cape Fear River water dissolved organic carbon to Long Bay, southeastern United States

NASA Astrophysics Data System (ADS)

Avery, G. Brooks; Kieber, Robert J.; Willey, Joan D.; Shank, G. Christopher; Whitehead, Robert F.

2004-09-01

The hurricane flux of rain and river water dissolved organic carbon (DOC) to Long Bay located on the southeastern coast of the United States was determined for four hurricanes that made landfall in the Cape Fear region of North Carolina. Riverine flux of DOC following hurricanes Fran (1996) and Floyd (1999) represented one third and one half of the entire annual river flux of DOC to Long Bay, respectively. The majority of this DOC was recalcitrant and not available for biological consumption. The high flux of DOC from hurricane Floyd resulted from extremely high precipitation amounts (in excess of 50 cm) associated with the hurricane and subsequent flooding. High riverine DOC fluxes were observed following hurricane Fran but not hurricanes Bertha (1996) and Bonnie (1998). The westerly path of Fran deposited rain inland along the Cape Fear River watershed, causing high river flow conditions, while Bonnie and Bertha took an eastern path, resulting in a minimal effect to the Cape Fear River flow rates. The rainwater flux of total DOC to Long Bay from the four hurricanes was not as dramatic as that observed for riverine fluxes. However, unlike river water DOC that is refractory, rainwater DOC is highly labile. Rainwater from the four hurricanes in this study deposited 2-5 times the DOC deposited in an average storm. This represented a flux of 3-9% of the entire annual budget of bioavailable DOC to Long Bay being deposited over a 1 or 2 day period, likely spurring short-term secondary productivity following the hurricanes.

Water-level conditions in the upper Cape Fear aquifer, 1992-94, in parts of Bladen and Robeson counties, North Carolina

USGS Publications Warehouse

Strickland, Alfred Gerald

1995-01-01

Water-level measurements were made on a periodic basis in 16 wells throughout an area of about 730 square miles in Bladen and Robeson Counties, North Carolina, from September 1992 to October 1994. Water levels from the wells were used to construct a map of the potentiometric surface of the upper Cape Fear aquifer in the fall of 1994. This map can be used to infer the direction of ground-water movement in the aquifer. Withdrawals from wells at pumping centers, such as in the Tar Heel and Elizabethtown areas, has disrupted the natural pattern of ground-water flow. Ground water flows toward pumped wells resulting in cones of depression in the potentiometric surface. Water levels measured in 14 wells in 1992 and 1994 were used to estimate change in ground-water levels for the upper Cape Fear aquifer in the study area. During 1992-94, water-level declines occurred in the aquifer throughout much of the area as a result of pumping. The greatest decline was 90.6 feet in Bladen County.

Hydrogeologic framework of the North Carolina coastal plain

USGS Publications Warehouse

Winner, M.D.; Coble, R.W.

1996-01-01

The hydrogeologic framework of the North Carolina Coastal Plain aquifer system consists of 10 aquifers separated by 9 confining units. From top to bottom, the aquifers are the surficial aquifer, Yorktown aquifer, Pungo River aquifer, Castle Hayne aquifer, Beaufort aquifer, Peedee aquifer, Black Creek aquifer, upper Cape Fear aquifer, lower Cape Fear aquifer, and Lower Cretaceous aquifer. The uppermost aquifer (the surficial aquifer in most places) is a water-table aquifer, and the bottom of the system is underlain by crystalline bedrock. The sedimentary deposits forming the aquifers are of Holocene to Cretaceous age and are composed mostly of sand, with lesser amounts of gravel and limestone. The confining units between the aquifers are composed primarily of clay and silt. The thickness of the aquifers ranges from zero along the Fall Line to more than 10,000 feet at Cape Hatteras. Prominent structural features are the increasing easterly homoclinal dip of the sediments and the Cape Fear arch, the axis of which trends in a southeast direction. Stratigraphic continuity was determined from correlations of 161 geophysical logs along with data from drillers? and geologists? logs. Aquifers were defined by means of these logs as well as water-level and water-quality data and evidence of the continuity of pumping effects. Eighteen hydrogeologic sections depict the correlation of these aquifers throughout the North Carolina Coastal Plain.

A History of Repeated Failures: Stratigraphy of the Currituck and Cape Fear Slide Complexes on the Central U.S. Atlantic Margin

NASA Astrophysics Data System (ADS)

Hill, J. C.; Brothers, D. S.; Ten Brink, U. S.

2016-12-01

The Currituck and Cape Fear Slide complexes, offshore of North Carolina, are two of the largest (>150 km3) submarine slope failure provinces on the U.S. Atlantic margin. Detailed stratigraphy of these slides and the surrounding regions is derived from a combination of high-resolution sparker multichannel seismic (MCS) data collected by the USGS in 2012, airgun MCS collected as part of the NSF GeoPRISMs Community Seismic Experiment in 2014 & legacy industry airgun MCS data collected in 1970s and 80s. Both the Currituck and Cape Fear Slide complexes are located in regions with high sediment input that resulted in the development of a broad, low gradient (<6°) margin with thick slope sediment accumulation since at least the Miocene. Bedding parallel failure planes highlight the influence of subsurface stratigraphy here. Differential compaction across buried scarps and other erosional surfaces found in proximity to many of the headwalls may have contributed to excess pore pressure in these zones, setting the stage for repeated failures. Within the Currituck Slide complex, there appear to be several buried mass transport deposits (MTDs) within both the Quaternary and Pliocene sections that may be related to buried scarps found beneath both the upper and lower headwalls. At the Cape Fear Slide, the Quaternary section upslope of a large salt diapir displays evidence of possible downslope creep folding within strata that downlap onto a possible buried failure plane. While submarine slope failure along this portion of the margin has long been linked with hydrate dissociation and/or salt tectonics, features that are pervasive along the margin, our new stratigraphic analyses suggest that antecedent margin physiography and sediment loading may be critical factors in determining the locations of large-scale slope failures.

Determination of flow losses in the Cape Fear River between B. Everett Jordan Lake and Lillington, North Carolina, 2008-2010

USGS Publications Warehouse

Weaver, J. Curtis; McSwain, Kristen Bukowski

2013-01-01

During 2008-2010, the U.S. Geological Survey conducted a hydrologic investigation in cooperation with the Triangle J Council of Governments Cape Fear River Flow Study Committee and the North Carolina Division of Water Resources to collect hydrologic data in the Cape Fear River between B. Everett Jordan Lake and Lillington in central North Carolina to help determine if suspected flow losses occur in the reach. Flow loss analyses were completed by summing the daily flow releases at Jordan Lake Dam with the daily discharges at Deep River at Moncure and Buckhorn Creek near Corinth, then subtracting these values from the daily discharges at Cape Fear River at Lillington. Examination of long-term records revealed that during 10,227 days of the 1983-2010 water years, 408 days (4.0 percent) had flow loss when conditions were relatively steady with respect to the previous day's records. The flow loss that occurred on these 40 days ranged from 0.49 to 2,150 cubic feet per second with a median flow loss of 37.2 cubic feet per second. The months with the highest number of days with flow losses were June (16. percent), September (16.9 percent), and October (19.4 percent). A series of synoptic discharge measurements made on six separate days in 2009 provided "snapshots" of overall flow conditions along the study reach. The largest water diversion is just downstream from the confluence of the Haw and Deep Rivers, and discharges substantially decrease in the main stem downstream from the intake point. Downstream from Buckhorn Dam, minimal gain or loss between the dam and Raven Rock State Park was noted. Analyses of discharge measurements and ratings for two streamgages-one at Deep River at Moncure and the other at Cape Fear River at Lillington-were completed to address the accuracy of the relation between stage and discharge at these sites. The ratings analyses did not indicate a particular time during the 1982-2011 water years in which a consistent bias occurred in the computations of discharge records that would indicate false flow losses. A total of 34 measured discharges at a streamgage on the Haw River below B. Everett Jordan Lake near Moncure were compared with the reported hourly flow releases from Jordan Lake Dam. Because 28 of 34 measurements were within plus or minus 10 percent of the hourly flow releases reported by the U.S Army Corps of Engineers, use of the current discharge computation tables for reporting Jordan Lake Dam flow releases is generally supported. A stage gage was operated on the Cape Fear River at Buckhorn Dam near Corinth to collect continuous stage-only records. Throughout the study period, flow over the dam was observed along its length, and flow loss within the study reach is not attributed to river-level fluctuations at the dam. Water-use information and (or) data were obtained for five industrial facilities, a regional power utility, two municipalities, one small hydropower facility on the Deep River, and one quarry operation also adjacent to the Deep River. The largest water users are the regional power producer, a small hydropower operation, and the two municipalities. The total water-use diversions for these facilities range from almost 25.5 to 38.5 cubic feet per second (39.5 to 59.5 million gallons per day) during the winter and summer periods, respectively. This range is equivalent to 69 to 104 percent of the 37 cubic feet per second median flow loss. The Lockville hydropower station is on the Deep River about 1 mile downstream from the streamgage near Moncure. Run-of-river operations at the facility do not appear to affect flow losses in the study reach. The largest water user in the study area is a regional power producer at a coal-fired power-generation plant located immediately adjacent to the Cape Fear River just downstream from the confluence of the Haw an Deep Rivers. Comparisons of daily water withdrawals, sup-plied by the regional power producer, and discharge records at a streamgage on the diversion canal indicated many days when consumption exceeded the producer's estimates for the cooling towers. Uncertainty surrounding reasonable estimates of consumption remained in effect at the end of the study. Data concerning evaporative losses were compiled using two approaches-an analysis of available pan-evaporation data from a National Weather Service cooperative observer station in Chapel Hill, North Carolina; and a compilation of reference open-water evaporation computed by the State Climate Office of North Carolina. The potential flow loss by evaporation from the main stem and the Deep River was estimated to be in the range of 4 to 14 cubic feet per second during May through October, equivalent to 10 to 38 percent of the 37 cubic feet per second median flow loss. Daily water-use diversions and evaporation losses were compared to flow-loss occurrences during the period April 2008 through September 2010. In comparing the surface-water, water-use, and evaporation data compiled for 2008-2010, it is evident that documented water diversions combined with flow losses by open-water evaporation can exceed the net flow gain in the study area and result in flow losses from the reach. Analysis of data from a streamgage downstream from the regional power plant on the diversion canal adjacent to the Cape Fear River provided insight into the occurrence of an apparent flow loss at the streamgage at Lillington. Assessment of the daily discharges and subsequent hydrographs for the canal streamgage indicated at least 24 instances during the study when the flows suddenly changed by magnitudes of 100 to more that 200 cubic feet per second, resulting in a noted time-lag effect on the downstream discharges at the Lillington streamgage, beginning 8 to 16 hours after the sudden flow change. A fiber-optic distributed temperature-sensing survey was conducted on the Cape Fear River at the Raven Rock State Park reach August 12-14, 2009, to determine if the presence of diabase dikes were preferentially directing groundwater discharge. No temperature anomalies of colder water were measured during the survey, which indicated that at the time of the survey that particular reach of the Cape Fear River was a "no-flow" or losing stream. An aerial thermal-infrared survey was conducted on the Haw and Cape Fear Rivers on February 27, 2010, from Jordan Lake Dam to Lillington to qualitatively delineate areas of groundwater discharge on the basis of the contrast between warm groundwater discharge and cold surface-water temperatures. Dis-charge generally was noted as diffuse seepage, but in a few cases springs were detected as inflow at a discrete point of discharge. Two reaches of the Cape Fear River (regional power plant and Bradley Road reaches) were selected for groundwater monitoring with a transect of piezometers installed within the flood plain. Groundwater-level altitudes at these reaches were analyzed for 1 water year (October 1, 2009, to September 30, 2010). Data collected as part of this study represent only a brief period of time and may not represent all conditions and all years; however, the data indicate that, during the dry summer months, the Cape Fear River within the study area is losing an undetermined quantity of water through seepage. Analyses completed during this investigation indicate a study reach with complex flow patterns affected by numerous concurrent factors resulting in flow losses. The causes of flow loss could not be solely attributed to any one factor. Among the factors considered, the occurrences of water diversions and evaporative losses were determined to be sufficient on some days (particularly during the base-flow period) to exceed the net gain in flows between the upstream and downstream ends of the study area. Losses by diversions and evaporation can exceed the median flow loss of 3 cubic feet per second, which indicates that flow loss from the study reach is real. Groundwater data collected during 2009-2010 indicate the possibility of localized flow loss during the summer, particularly in the impounded reach above Buckhorn Dam. However, no indication of unusual patterns was noted that would cause substantial flow loss by groundwater and surface-water interaction at the river bottom.

History of ground-water pumpage and water-level decline in the Black Creek and upper Cape Fear aquifers of the central coastal plain of North Carolina

USGS Publications Warehouse

Winner, M.D.; Lyke, W.L.

1986-01-01

Historical ground-water withdrawals and a general water-level decline in the Black Creek and upper Cape Fear aquifers of the central Coastal Plain of North Carolina are documented. Total municipal and industrial pumpage from these aquifers has increased from approximately 120,000 gal/day (gpd) in 1910 to >21 million gpd in 1980. Major pumpage, > 10,000 gpd, began around 1900. Since that time, per capita water use in the central Coastal Plain area has ranged from 17 to 172 gpd/person. The higher values partially represent the increasing availability and use of modern conveniences since the World War II era. The range of per capita water use can be subdivided according to general water-use and population characteristics for both urban and rural areas. The pumpage of ground water from the Black Creek and upper Cape Fear aquifers has created water-level declines from 0.5 to 4.9 ft/year since 1900. Approximately a third of the study area has experienced a decline > 50 ft up to the period 1979-1981, with 148 ft being the maximum.

Bathymetry at the head of the Cape Fear Slide, offshore North Carolina

USGS Publications Warehouse

Schmuck, Eric A.; Popenoe, Peter; Paull, Charles K.; Brown, Carol

1992-01-01

The Cape Fear Slide is the largest mass-movement that has been observed on the U.S. Atlantic Margin. It is located off the Carolinas on the continental rise in approximately 1,200-5,500 m water depth and extends downslope for over 300 km (Popenoe, 1982). These maps show the bathymetry at the head of the Cape Fear Slide as interpreted from single-channel 3.5 kHz seismic-reflection profiles and mid-range Sea Marc I sidescan sonar imagery (Popenoe, 1985; Popenoe and others, 1991; Schmuck, 1991). The 3.5 kHz data consist of over 1000 km of profiles that were collected in 1988 for the University of North Carolina, Department of Geology. The UNC 3.5 kHz data were used as the main data set in interpreting the bathymetry. The sidescan sonar data were collected in 1980 by the U.S. Geological Survey in cooperation with the Lamont-Doherty Geological Observatory for the U.S. Bureau of Land Management Environmental Studies Program. Only 28 km (5 km swath width) of the sidescan data were used in the interpretation to identify the morphology of the main slump scarp and visible secondary scarps.

Water-quality characteristics for selected sites on the Cape Fear River, North Carolina, 1955-80; variability, loads, and trends of selected constituents

USGS Publications Warehouse

Crawford, J. Kent

1983-01-01

Water-quality data for selected sites in the Cape Fear River basin collected by the U.S. Geological Survey, the North Carolina Department of Natural Resources and Community Development and the University of North Carolina at Chapel Hill are analyzed and interpreted in this report. Emphasis is given to the Cape Fear River at Lock 1 near Kelly, where data are most complete. Other data included in the report were collected from the Cape Fear River at Lillington, the Haw River near the Jordan Dam, and the Deep River at Moncure. Available data indicate that concentrations of dissolved oxygen at study sites are almost always within U.S. Environmental Protection Agency criteria; however, on two sampling dates, the concentration of dissolved oxygen in the Cape Fear at Lock 1 fell slightly below the 5.0 mg/L recommended for fish populations. Measurements of pH from all stations were frequently below the lower limit of 6.5 pH units recommended for protection of freshwater aquatic life. Major dissolved ions detected are sodium and bicarbonate. Sodium concentration averages 8.6 mg/L and bicarbonate averages 17.5 mg/L at Lock 1. Concentrations of dissolved substances and suspended sediment decrease in the downstream direction, presumably because the more heavily populated part of the basin is near the headwaters of the system. Heavy metals, with the exceptions of cadmium and mercury, rarely exceed Environmental Protection Agency criteria for the protection of aquatic life. Concentrations of mercury in the Haw River, which exceed the recommended 0.20 mg/L needed to protect aquatic life, have frequently been reported by other authors. Several of the most toxic metals, arsenic, cadmium, and cobalt, are about five times more concentrated in water from the Haw River site than from other study sites in the basin. Iron and manganese frequently exceed North Carolina water-quality standards. Available nitrogen averages 1.21 mg/L and available phosphorus averages 0.21 mg/L at Lock 1. Nuisance algal growths have not been identified as a problem in the river. Comparisons of water-quality data for baseline (natural) and present conditions indicate that more than 50 percent of most dissolved substances and over 80 percent of certain forms of nitrogen and phosph6rus result from development. Over the past 25 years, increases in concentrations of specific conductance, dissolved magnesium, dissolved sodium, dissolved potassium, dissolved sulfate, dissolved solids, and total nitrite plus nitrate nitrogen were detected in the Cape Fear River at Lock 1. Values for pH and dissolved silica are decreasing. Concentrations of most dissolved constituents at Lock 1 are increasing. These increases are statistically related to increases in population and manufacturing employment in the basin but are unrelated to agricultural activity.

Low-Flow Characteristics and Discharge Profiles for Selected Streams in the Cape Fear River Basin, North Carolina, Through 1998

USGS Publications Warehouse

Weaver, J.C.; Pope, B.F.

2001-01-01

An understanding of the magnitude and frequency of low-flow discharges is an important part of evaluating surface-water resources and planning for municipal and industrial economic expansion. Low-flow characteristics are summarized in this report for 67 continuous-record gaging stations and 121 partial-record measuring sites in the Cape Fear River Basin of North Carolina. Records of discharge collected through the 1998 water year were used in the analyses. Flow characteristics included in the summary are (1) average annual unit flow; (2) 7Q10 low-flow discharge, the minimum average discharge for a 7-consecutive-day period occurring, on average, once in 10 years; (3) 30Q2 low-flow discharge; (4) W7Q10 low-flow discharge, similar to 7Q10 discharge except that only flow during November through March is considered; and (5) 7Q2 low-flow discharge. Low-flow characteristics in the Cape Fear River Basin vary widely in response to changes in geology and soil types. The area of the basin with the lowest potentials for sustained base flows is underlain by the Triassic basin in parts of Durham, Wake, and Chatham Counties. Typically, these soils are derived from basalt and fine-grained sedimentary rocks that allow very little infiltration of water into the shallow aquifers for storage and later release to streams during periods of base flow. The area of the basin with the highest base flows is the Sand Hills region in parts of Moore, Harnett, Hoke, and Cumberland Counties. Streams in the Sand Hills have the highest unit low flows in the study area as well as in much of North Carolina. Well-drained sandy soils in combination with higher topographic relief relative to other areas in the Coastal Plain contribute to the occurrence of high potentials for sustained base flows. A number of sites in the upper part of the Cape Fear River Basin underlain by the Carolina Slate Belt and Triassic basin, as well many sites in lower areas of the Coastal Plain (particularly the Northeast Cape Fear River Basin), have zero or minimal (defined as less than 0.05 cubic foot per second) 7Q10 discharges. In this area, the poorly sustained base flows are reflective of either (1) thin soils that have very little storage of water to sustain streams during base-flow periods (Carolina Slate Belt), or (2) soils having very low infiltration rates (Triassic basin). As a result, there is insufficient water stored in the surficial aquifers for release to streams during extended dry periods. Within the part of the study area underlain by the Carolina Slate Belt, streams draining basins 5 square miles or less may have zero or minimal 7Q10 discharges. The part of the study area underlain by the Triassic basin has a higher drainage-area threshold at 35 square miles, below which streams will likely have zero or minimal 7Q10 discharges. Occurrences of zero or minimal 7Q10 discharges in the Coastal Plain were noted, though on a more widespread basis. In this area, low flows are more likely affected by the presence of poorly drained soils in combination with very low topographic relief relative to other areas in the Coastal Plain, particularly the Sand Hills. In eastern Harnett County and northeastern Cumberland County, basins with less than 3 square miles may be prone to having zero or minimal 7Q10 discharges. Soils in this area have been described as a mixture of sandy and clay soils. In the Northeast Cape Fear River Basin, particularly on the western side of the river, streams draining less than 8 square miles may have zero or minimal 7Q10 discharges. The poorly drained clay soils along with very little topographic relief results in the low potential for sustained base flows in this part of the study area. Drainage area and low-flow discharge profiles are presented for 13 streams in the Cape Fear River Basin; these profiles reflect a wide range in basin size, characteristics, and streamflow conditions. In addition to the Haw River and Cape Fear River main stem, pro

Condom Negotiation, HIV Testing, and HIV Risks among Women from Alcohol Serving Venues in Cape Town, South Africa

PubMed Central

Pitpitan, Eileen V.; Kalichman, Seth C.; Cain, Demetria; Eaton, Lisa A.; Carey, Kate B.; Carey, Michael P.; Harel, Ofer; Simbayi, Leickness C.; Mehlomakhulu, Vuyelwa; Mwaba, Kelvin

2012-01-01

Background Women in South Africa are at particularly high-risk for HIV infection and are dependent on their male partners' use of condoms for sexual risk reduction. However, many women are afraid to discuss condoms with male partners, placing them at higher risk of HIV infection. Purpose To examine the association between fear of condom negotiation with HIV testing and transmission risk behaviors, including alcohol use and sexual risks among South African women. Method Women (N = 1333) residing in a primarily Xhosa-speaking African township in Cape Town and attending informal alcohol-serving venues (shebeens) completed anonymous surveys. Logistic regression was used to test the hypothesis that fear of condom negotiation would be associated with increased risk for HIV. Results Compared to women who did not fear condom negotiation, those who did were significantly less likely to have been tested for HIV, were more likely to have experienced relationship abuse, and to report more alcohol use and more unprotected sex. Conclusions For women in South Africa, fear of condom negotiation is related to higher risk of HIV. HIV prevention efforts, including targeted HIV counseling and testing, must directly address gender issues. PMID:23056211

33 CFR 80.525 - Cape Lookout, NC to Cape Fear, NC.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Shackleford Banks. (b) A line drawn from Morehead City Channel Range Front Light to the seaward extremity of... the southwest side of New River Inlet at latitude 34°31.5′ N. longitude 77°20.6′ W. to the seaward tangent of the shoreline on the northeast side on New River Inlet. (e) A line drawn across New Topsail...

77 FR 1406 - Drawbridge Operation Regulations; Northeast Cape Fear River, Wilmington, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... draw span to facilitate structural, electrical and mechanical upgrades and repairs of the bridge. DATES... structural, electrical and mechanical upgrades and repairs of the bridge. Under the regular operating...

33 CFR 117.829 - Northeast Cape Fear River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... maintenance authorized in accordance with Subpart A of this part. (3) Trains shall be controlled so that any... of failure or obstruction of the motion sensors, laser scanners, video cameras or marine-radio...

33 CFR 117.829 - Northeast Cape Fear River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... maintenance authorized in accordance with Subpart A of this part. (3) Trains shall be controlled so that any... of failure or obstruction of the motion sensors, laser scanners, video cameras or marine-radio...

Implementation of a pharmacist-driven immunization program designed to improve overall vaccination rates in indigent and uninsured patients.

PubMed

Stilwell, Allison M; Pavero, Chris; Buxton, Jennifer; Herrington, Glenn

To demonstrate the results of a pharmacist-driven immunization program designed to increase overall vaccination rates among the low-income, uninsured patients in a free clinic. Cape Fear Clinic, a free clinic located in Wilmington, North Carolina. Cape Fear Clinic provides medical, pharmacy, mental health, and dental services to adults in 4 eastern North Carolina counties who are uninsured and have incomes of no more than 200% of Federal Poverty Guidelines. A pharmacist-driven immunization program consisting of a comprehensive chart review of every active clinic patient in order to improve the vaccination status of the clinic's patients at no cost to the patient. Student pharmacists completed a comprehensive chart review of every active clinic patient to identify patients eligible for immunizations according to the Advisory Committee on Immunization Practices guidelines. More than 500 patients eligible for immunizations were notified of their immunization status and educated about indicated vaccinations. Patients willing to receive indicated vaccinations would present to the pharmacy and a pharmacist or student pharmacist administered the necessary doses. The vaccine initiative was introduced January 1, 2015 and has since delivered 1878 doses of vaccines as of June 30, 2016. The immunization program implemented by pharmacists and student pharmacists at Cape Fear Clinic has been successful in increasing awareness of vaccine preventable diseases as well as increasing rates of vaccination among eligible clinic patients. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

33 CFR 117.829 - Northeast Cape Fear River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... passage of trains and to perform periodic maintenance authorized in accordance with Subpart A of this part... controller at the CSX Navassa Railroad in the event of failure or obstruction of the motion sensors, laser...

33 CFR 117.829 - Northeast Cape Fear River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... passage of trains and to perform periodic maintenance authorized in accordance with Subpart A of this part... controller at the CSX Navassa Railroad in the event of failure or obstruction of the motion sensors, laser...

33 CFR 167.251 - In the approaches to the Cape Fear River: Precautionary area.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.251 In the...

33 CFR 167.251 - In the approaches to the Cape Fear River: Precautionary area.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.251 In the...

33 CFR 167.251 - In the approaches to the Cape Fear River: Precautionary area.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.251 In the...

33 CFR 167.251 - In the approaches to the Cape Fear River: Precautionary area.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.251 In the...

Ground-water level data for North Carolina, 1988-90

USGS Publications Warehouse

Strickland, A.G.; Coble, R.W.; Edwards, L.A.; Pope, B.F.

1992-01-01

Continuous and periodic water-level measurements were made in 59 key wells throughout North Carolina. Additional measurements were made in 112 supplementary wells completed in Coastal Plain aquifers of the State. Changes in groundwater storage are shown in 3-year and 10-year hydrographs of selected wells in the State. The water table in the shallow aquifers was higher throughout most of 1989 and early 1990 than in 1988, indicating that these aquifers were sufficiently recharged by precipitation to replenish the late 1987-88 deficit in groundwater storage. Water levels in the heavily pumped Coastal Plain aquifers declined as a result of water being withdrawn from aquifer storage. Record low water levels were measured in 8 to 13 wells completed in the Castle Hayne aquifer and in 6 of 8 wells in the Peedee aquifer; the maximum annual declines during 1988-90 averaged 3.3 and 1.6 ft/yr, respectively, for these two aquifers. All wells in the Black Creek, upper Cape Fear, and lower Cape Fear aquifers had record low water levels during 1988-90, with maximum annual declines averaging 9.0, 2.2, and 2.6 ft/yr, respectively. Water levels in two of three wells in the Yorktown aquifer did not show a general downward trend during 1988-90, although water levels declined in the third well, reaching a record low in 1990. The effects of water withdrawals from major pumping centers in the North Carolina Coastal Plain are shown in potentiometric-surface maps of the Black Creek and lower Cape Fear aquifers.

View of the nose of the orbiter taken from the Mir space station

NASA Image and Video Library

1997-01-29

STS081-720-081 (12-22 Jan. 1997) --- As seen from Russia's Mir space station while docked to the Space Shuttle Atlantis, this scene provides a panorama of the central Atlantic coast of the United States. The view extends from the Chesapeake Bay at the top of the view to Charleston, South Carolina near the lower right corner. Heavy snow-cover on the Appalachian Mountains (on the left of the photo) contrasts with the darker piedmont. The dark piedmont, in turn, changes sharply in the center of the photo to the gray-colored coastal plain. Cape Hatteras, Cape Lookout and Cape Fear (top to bottom) mark the points along the North Carolina coast. Another boundary can be seen offshore. The clouds and the line of lighter-colored water off Cape Hatteras mark the western edge of the warm Gulf Stream which runs northward along the coast to Cape Hatteras before it shoots eastward across the Atlantic.

PERFLUORINATED COMPOUNDS IN THE CAPE FEAR DRAINAGE BASIN IN NORTH CAROLINA

EPA Science Inventory

Concern over perfluorinated organic compounds (PFCs), e.g., perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), is due to a number of recent studies which show that the PFCs are persistent, bioaccumulative, and toxic. Despite sustained interest in this topic, lit...

Hydrology of major estuaries and sounds of North Carolina

USGS Publications Warehouse

Giese, G.L.; Wilder, Hugh B.; Parker, Garald G.

1985-01-01

Hydrology-related problems associated with North Carolina 's major estuaries and sounds include contamination of some estuaries with municipal and industrial wastes and drainage from adjacent, intensively farmed areas, and nuisance-level algal blooms. In addition, there is excessive shoaling in some navigation channels, salt-water intrusion into usually fresh estuarine reaches, too high or too-low salinities in nursery areas for various estuarine species, and flood damage due to hurricanes. The Cape Fear River is the only major North Carolina estuary having a direct connection to the sea. Short-term flow throughout most of its length is dominated by ocean tides. Freshwater entering the major estuaries is, where not contaminated, of acceptable quality for drinking with minimum treatment. However, iron concentrations in excess of 0.3 milligrams per liter sometimes occur and water draining from swampy areas along the Coastal Plain is often highly colored, but these problems may be remedied with proper treatment. Nuisance-level algal blooms have been a recurring problem on the lower estuarine reaches of the Neuse, Tar-Pamlico, and Chowan Rivers where nutrients (compounds of phosphorous and nitrogen) are abundant. The most destructive blooms tend to occur in the summer months during periods of low freshwater discharge and relatively high water temperatures. Saltwater intrusion occurs from time to time in all major estuaries except the Roanoke River, where releases from Roanoke Rapids Lake and other reservoirs during otherwise low-flow periods effectively block saline water from the estuary. New shoaling materials found in the lower channelized reaches of the Cape Fear and Northeast Cape Fear Rivers are primarily derived, not from upstream sources, but from nearby shore erosion, from slumping of material adjacent to the dredged channels, from old spoil areas, or from ocean-derived sediments carried upstream by near-bottom density currents.

Assessing hog lagoon waste contamination in the Cape Fear Watershed using Bacteroidetes 16S rRNA gene pyrosequencing.

PubMed

Arfken, Ann M; Song, Bongkeun; Mallin, Michael A

2015-09-01

Hog lagoons can be major sources of waste and nutrient contamination to watersheds adjacent to pig farms. Fecal source tracking methods targeting Bacteroidetes 16S rRNA genes in pig fecal matter may underestimate or fail to detect hog lagoon contamination in riverine environments. In order to detect hog lagoon wastewater contamination in the Cape Fear Watershed, where a large number of hog farms are present, we conducted pyrosequencing analyses of Bacteroidetes 16S rRNA genes in hog lagoon waste and identified new hog lagoon-specific marker sequences. Additional pyrosequencing analyses of Bacteroidetes 16S rRNA genes were conducted with surface water samples collected at 4 sites during 5 months in the Cape Fear Watershed. Using an operational taxonomic unit (OTU) identity cutoff value of 97 %, these newly identified hog lagoon markers were found in 3 of the river samples, while only 1 sample contained the pig fecal marker. In the sample containing the pig fecal marker, there was a relatively high percentage (14.1 %) of the hog lagoon markers and a low pig fecal marker relative abundance of 0.4 % in the Bacteroidetes 16S rRNA gene sequences. This suggests that hog lagoon contamination must be somewhat significant in order for pig fecal markers to be detected, and low levels of hog lagoon contamination cannot be detected targeting only pig-specific fecal markers. Thus, new hog lagoon markers have a better detection capacity for lagoon waste contamination, and in conjunction with a pig fecal marker, provide a more comprehensive and accurate detection of hog lagoon waste contamination in susceptible watersheds.

Hydrologic and water-chemistry data from the Cretaceous-aquifers test well (BFT-2055), Beaufort County, South Carolina

USGS Publications Warehouse

Landmeyer, J.E.; Bradley, P.M.

1998-01-01

Test well BFT-2055 was drilled through the entire thickness of Coastal Plain sediments beneath central Hilton Head Island, South Carolina, and terminated in bedrock at a depth of 3833 feet. The well was drilled to evaluate the hydraulic properties of the Cretaceous formations beneath Hilton Head Island as a potential source of supplemental water to supplies currently withdrawn from the Upper Floridan aquifer. The intervals tested include sediments of the Cape Fear and Middendorf Formations. Results from aquifer tests indicate that the transmissivity of the formations screened ranges from 1300 to 3000 feet squared per day and an average hydraulic conductivity of about 15 feet per day. Formation-fluid pressure tests indicate that the potential exists for upward ground-water flow from higher fluid pressures in the deeper Cape Fear and Middendorf Formations to lower fluid pressures in the Black Creek Formation and shallower units. A flowmeter test indicated that greater than 75 percent of the natural, unpumped flow in the well is from the screened intervals no deeper than 3100 feet. Water-chemistry analyses indicate that the water sampled from the Middendorf and Cape Fear has about 1450 milligrams per liter dissolved solids, 310 to 1000 milligrams per liter sodium, and 144 to 1600 milligrams per liter chloride. Because these chloride concentrations would render water pumped from these aquifers as nonpotable, it is unlikely that these aquifers will be used as a supplemental source of water for island residents without some form of pretreatment. Similar chloride concentrations are present in some wells in the Upper Floridan aquifer adjacent to Port Royal Sound, and these chloride concentrations were the primary reason for drilling the test well in the Cretaceous formations as a possible source of more potable water.

Geographic and stratigraphic distribution of coastal Quaternary aminozones across the Cape Fear Arch, U. S. Atlantic Geology Coastal Plain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wehmiller, J.F.; York, L.L.; Krantz, D.E.

1992-01-01

The interpretation of the regional aminostratigraphy of Coastal Plain Quaternary units from North and South Carolina is potentially affected by sampling biases, variable preservation of coastal records, reoccupation of coastal environments by multiple transgressions, geochemical alteration of samples, variable thermal histories of specific samples, and intergeneric and interlaboratory differences in analytical results.Two primary models for the correlation of emergent Coastal Plain units diverge significantly in southeastern North Carolina. New data from fresh exposure (1990--1991) at emergent sites between Wilmington, NC and Charleston, SC, from previous onshore collections in this region, and from submergent samples between Cape Lookout, NC and Capemore » Romain, SC provide insight into the nature of these correlation issues. Although sampling of the area is not uniform, these results fill a major gap between regions of previous aminostratigraphy study. Inferred early-to-middle Pleistocene aminozones dominate the emergent coastal region between Cape Lookout and Romain, and late Pleistocene aminozones in this area are represented by subsurface samples beneath barrier islands or in shallow inner shelf cores, but have not been found onshore. A map view of the distribution of aminozones along the coast between northeastern NC and central SC mimics that of pre-Quaternary units that thin or disappear over the axis of the Cape Fear Arch, suggesting that the sampled Quaternary record reflects the combination of processes responsible for the preservation of the pre-Quaternary record. This perspective should provide a model for resolution of various geochronological controversies that have arisen because of limited stratigraphic or geochemical data.« less

78 FR 65301 - Notice of Availability of a Draft Supplement to the July 2011 Environmental Impact Statement for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... the north by the Northeast Cape Fear River, Holly Shelter Game Lands to the east, and Market Street and US 17 to the south. This project is being reviewed through the Merger 01 process designed to...

76 FR 59122 - Notice of Availability of a Draft Environmental Impact Statement in Cooperation With the North...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

... the north by the Northeast Cape Fear River, Holly Shelter Game Lands to the east, and Market Street... document online can contact the COE project manager or the NCDOT project manager for a CD copy of the...

46 CFR 7.45 - Cape Henlopen, DE to Cape Charles, VA.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Cape Henlopen, DE to Cape Charles, VA. 7.45 Section 7.45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.45 Cape Henlopen, DE to Cape Charles, VA. (a) A line drawn from the easternmost...

'Cape capture': Geologic data and modeling results suggest the holocene loss of a Carolina Cape

USGS Publications Warehouse

Thieler, E.R.; Ashton, A.D.

2011-01-01

For more than a century, the origin and evolution of the set of cuspate forelands known as the Carolina Capes-Hatteras, Lookout, Fear, and Romain-off the eastern coast of the United States have been discussed and debated. The consensus conceptual model is not only that these capes existed through much or all of the Holocene transgression, but also that their number has not changed. Here we describe bathymetric, lithologic, seismic, and chronologic data that suggest another cape may have existed between Capes Hatteras and Lookout during the early to middle Holocene. This cape likely formed at the distal end of the Neuse-Tar-Pamlico fiuvial system during the early Holocene transgression, when this portion of the shelf was fiooded ca. 9 cal (calibrated) kyr B.P., and was probably abandoned by ca. 4 cal kyr B.P., when the shoreline attained its present general configuration. Previously proposed mechanisms for cape formation suggest that the large-scale, rhythmic pattern of the Carolina Capes arose from a hydrodynamic template or the preexisting geologic framework. Numerical modeling, however, suggests that the number and spacing of capes can be dynamic, and that a coast can self-organize in response to a high-angle-wave instability in shoreline shape. In shoreline evolution model simulations, smaller cuspate forelands are subsumed by larger neighbors over millennial time scales through a process of 'cape capture.' The suggested former cape in Raleigh Bay represents the first interpreted geological evidence of dynamic abandonment suggested by the self-organization hypothesis. Cape capture may be a widespread process in coastal environments with large-scale rhythmic shoreline features; its preservation in the sedimentary record will vary according to geologic setting, physical processes, and sea-level history. ?? 2011 Geological Society of America.

46 CFR 7.155 - Cape Spencer, AK to Cape St. Elias, AK.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Cape Spencer, AK to Cape St. Elias, AK. 7.155 Section 7.155 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.155 Cape Spencer, AK to Cape St. Elias, AK. (a) A line drawn from the westernmost...

46 CFR 7.155 - Cape Spencer, AK to Cape St. Elias, AK.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Cape Spencer, AK to Cape St. Elias, AK. 7.155 Section 7.155 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.155 Cape Spencer, AK to Cape St. Elias, AK. (a) A line drawn from the westernmost...

46 CFR 7.155 - Cape Spencer, AK to Cape St. Elias, AK.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Cape Spencer, AK to Cape St. Elias, AK. 7.155 Section 7.155 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.155 Cape Spencer, AK to Cape St. Elias, AK. (a) A line drawn from the westernmost...

46 CFR 7.155 - Cape Spencer, AK to Cape St. Elias, AK.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Cape Spencer, AK to Cape St. Elias, AK. 7.155 Section 7.155 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.155 Cape Spencer, AK to Cape St. Elias, AK. (a) A line drawn from the westernmost...

46 CFR 7.155 - Cape Spencer, AK to Cape St. Elias, AK.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Cape Spencer, AK to Cape St. Elias, AK. 7.155 Section 7.155 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.155 Cape Spencer, AK to Cape St. Elias, AK. (a) A line drawn from the westernmost...

VARIATIONS IN THE SPECTRAL PROPERTIES OF FRESHWATER AND ESTUARINE CDOM CAUSED BY PARTITIONING ONTO RIVER AND ESTUARINE SEDIMENTS

EPA Science Inventory

The optical properties and geochemical cycling of chromophoric dissolved organic matter (CDOM) are altered by its sorption to freshwater and estuarine sediments. Measured partition coefficients (Kp) of Satilla River (Georgia) and Cape Fear River estuary (North Carolina) CDOM ran...

Contemporary and temporal investigation of per- and polyfluorinated compounds in Cape Fear river, North Carolina surface water samples

EPA Science Inventory

Recent regulatory pressure has altered the chemistry of per- and polyfluorinated compounds being manufactured and used in industrial and consumer applications. Many manufacturers have been moving toward the production of shorter chain per- and polyfluorinated compounds. A series ...

33 CFR 80.505 - Cape Henlopen, DE to Cape Charles, VA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Henlopen, DE to Cape Charles, VA. 80.505 Section 80.505 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.505 Cape Henlopen, DE...

‘Cape capture’: Geologic data and modeling results suggest the Holocene loss of a Carolina Cape

USGS Publications Warehouse

Thieler, E. Robert; Ashton, Andrew D.

2011-01-01

For more than a century, the origin and evolution of the set of cuspate forelands known as the Carolina Capes—Hatteras, Lookout, Fear, and Romain—off the eastern coast of the United States have been discussed and debated. The consensus conceptual model is not only that these capes existed through much or all of the Holocene transgression, but also that their number has not changed. Here we describe bathymetric, lithologic, seismic, and chronologic data that suggest another cape may have existed between Capes Hatteras and Lookout during the early to middle Holocene. This cape likely formed at the distal end of the Neuse-Tar-Pamlico fluvial system during the early Holocene transgression, when this portion of the shelf was flooded ca. 9 cal (calibrated) kyr B.P., and was probably abandoned by ca. 4 cal kyr B.P., when the shoreline attained its present general configuration. Previously proposed mechanisms for cape formation suggest that the large-scale, rhythmic pattern of the Carolina Capes arose from a hydrodynamic template or the preexisting geologic framework. Numerical modeling, however, suggests that the number and spacing of capes can be dynamic, and that a coast can self-organize in response to a high-angle-wave instability in shoreline shape. In shoreline evolution model simulations, smaller cuspate forelands are subsumed by larger neighbors over millennial time scales through a process of ‘cape capture.’ The suggested former cape in Raleigh Bay represents the first interpreted geological evidence of dynamic abandonment suggested by the self-organization hypothesis. Cape capture may be a widespread process in coastal environments with large-scale rhythmic shoreline features; its preservation in the sedimentary record will vary according to geologic setting, physical processes, and sea-level history.

Resilient or Resigned? Criminal Victimisation and Quality of Life in South Africa

ERIC Educational Resources Information Center

Moller, Valerie

2005-01-01

A victimisation study conducted among 3300 householders in South Africa's Nelson Mandela Metropolitan Municipality (NMMM) in the Eastern Cape Province aimed to inform a crime prevention strategy for the metropolitan area. The study found that the variables "fear of crime' measured in terms of perceived likelihood of victimisation--and concern…

77 FR 5186 - Drawbridge Operation Regulation; Northeast Cape Fear River, Wilmington, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... span to accommodate the 100 year Anniversary of the Girl Scout Program Ceremonial walk. The deviation.... SUPPLEMENTARY INFORMATION: The Event Director for the New Hanover County Girl Scouts, with approval from the... deviation from the current operating schedule to accommodate the 100 year Anniversary of the Girl Scout...

A network model shows the importance of coupled processes in the microbial N cycle in the Cape Fear River Estuary

NASA Astrophysics Data System (ADS)

Hines, David E.; Lisa, Jessica A.; Song, Bongkeun; Tobias, Craig R.; Borrett, Stuart R.

2012-06-01

Estuaries serve important ecological and economic functions including habitat provision and the removal of nutrients. Eutrophication can overwhelm the nutrient removal capacity of estuaries and poses a widely recognized threat to the health and function of these ecosystems. Denitrification and anaerobic ammonium oxidation (anammox) are microbial processes responsible for the removal of fixed nitrogen and diminish the effects of eutrophication. Both of these microbial removal processes can be influenced by direct inputs of dissolved inorganic nitrogen substrates or supported by microbial interactions with other nitrogen transforming pathways such as nitrification and dissimilatory nitrate reduction to ammonium (DNRA). The coupling of nitrogen removal pathways to other transformation pathways facilitates the removal of some forms of inorganic nitrogen; however, differentiating between direct and coupled nitrogen removal is difficult. Network modeling provides a tool to examine interactions among microbial nitrogen cycling processes and to determine the within-system history of nitrogen involved in denitrification and anammox. To examine the coupling of nitrogen cycling processes, we built a nitrogen budget mass balance network model in two adjacent 1 cm3 sections of bottom water and sediment in the oligohaline portion of the Cape Fear River Estuary, NC, USA. Pathway, flow, and environ ecological network analyses were conducted to characterize the organization of nitrogen flow in the estuary and to estimate the coupling of nitrification to denitrification and of nitrification and DNRA to anammox. Centrality analysis indicated NH4+ is the most important form of nitrogen involved in removal processes. The model analysis further suggested that direct denitrification and coupled nitrification-denitrification had similar contributions to nitrogen removal while direct anammox was dominant to coupled forms of anammox. Finally, results also indicated that partial nitrification-anammox may play an important role in anammox nitrogen removal in the Cape Fear River Estuary.

Assessing contaminant sensitivity of endangered and threatened aquatic species: Part III. Effluent toxicity tests

USGS Publications Warehouse

Dwyer, F.J.; Hardesty, D.K.; Henke, C.E.; Ingersoll, C.G.; Whites, D.W.; Augspurger, T.; Canfield, T.J.; Mount, D.R.; Mayer, F.L.

2005-01-01

Toxicity tests using standard effluent test procedures described by the U.S. Environmental Protection Agency were conducted with Ceriodaphnia dubia, fathead minnows (Pimephales promelas), and seven threatened and endangered (listed) fish species from four families: (1) Acipenseridae: shortnose sturgeon (Acipenser brevirostrum); (2) Catostomidae; razorback sucker (Xyrauchen texanus); (3) Cyprinidae: bonytail chub (Gila elegans), Cape Fear shiner (Notropis mekistocholas) Colorado pikeminnow (Ptychocheilus lucius), and spotfin chub (Cyprinella monacha); and (4) Poecillidae: Gila topminnow (Poeciliopsis occidentalis). We conducted 7-day survival and growth studies with embryo-larval fathead minnows and analogous exposures using the listed species. Survival and reproduction were also determined with C. dubia. Tests were conducted with carbaryl, ammonia-or a simulated effluent complex mixture of carbaryl, copper, 4-nonylphenol, pentachlorophenol and permethrin at equitoxic proportions. In addition, Cape Fear shiners and spotfin chub were tested using diazinon, copper, and chlorine. Toxicity tests were also conducted with field-collected effluents from domestic or industrial facilities. Bonytail chub and razorback suckers were tested with effluents collected in Arizona whereas effluent samples collected from North Carolina were tested with Cape Fear shiner, spotfin chub, and shortnose sturgeon. The fathead minnow 7-day effluent test was often a reliable estimator of toxic effects to the listed fishes. However, in 21 % of the tests, a listed species was more sensitive than fathead minnows. More sensitive species results varied by test so that usually no species was always more or less sensitive than fathead minnows. Only the Gila topminnow was consistently less sensitive than the fathead minnow. Listed fish species were protected 96% of the time when results for both fathead minnows and C. dubia were considered, thus reinforcing the value of standard whole-effluent toxicity tests using those two species. If the responses of specific listed species are important for management decisions, our study supports the value in developing culture and testing procedures for those species. ?? 2005 Springer Science+Business Media, Inc.

Quality of surface-water supplies in the Triangle area of North Carolina, water year 2009

USGS Publications Warehouse

Pfeifle, C. A.; Giorgino, M. J.; Rasmussen, R. B.

2014-01-01

Surface-water supplies are important sources of drinking water for residents in the Triangle area of North Carolina, which is located within the upper Cape Fear and Neuse River Basins. Since 1988, the U.S. Geological Survey and a consortium of governments have tracked water-quality conditions and trends in several of the area’s water-supply lakes and streams. This report summarizes data collected through this cooperative effort, known as the Triangle Area Water Supply Monitoring Project, during October 2008 through September 2009. Major findings for this period include: - Annual precipitation was approximately 20 percent below the long-term mean (average) annual precipitation. - Streamflow was below the long-term mean at the 10 project streamgages during most of the year. - More than 7,000 individual measurements of water quality were made at a total of 26 sites—15 in the Neuse River Basin and 11 in the Cape Fear River Basin. Forty-seven water-quality properties and constituents were measured. - All observations met North Carolina water-quality standards for water temperature, pH, hardness, chloride, fluoride, sulfate, nitrate, arsenic, cadmium, chromium, lead, nickel, and selenium. - North Carolina water-quality standards were exceeded one or more times for dissolved oxygen, dissolved oxygen percent saturation, chlorophyll a, mercury, copper, iron, manganese, silver, and zinc. Exceedances occurred at 23 sites—13 in the Neuse River Basin and 10 in the Cape Fear River Basin. - Stream samples collected during storm events contained elevated concentrations of 18 water-quality constituents compared to samples collected during non-storm events. - Concentrations of nitrogen and phosphorus were within ranges observed during previous years. - Five reservoirs had chlorophyll a concentrations in excess of 40 micrograms per liter at least once during 2009: Little River Reservoir, Falls Lake, Cane Creek Reservoir, University Lake, and Jordan Lake.

Inception of a false memory by optogenetic manipulation of a hippocampal memory engram.

PubMed

Liu, Xu; Ramirez, Steve; Tonegawa, Susumu

2014-01-05

Memories can be easily distorted, and a lack of relevant animal models has largely hindered our understanding of false-memory formation. Here, we first identified a population of cells in the dentate gyrus (DG) of the hippocampus that bear the engrams for a specific context; these cells were naturally activated during the encoding phase of fear conditioning and their artificial reactivation using optogenetics in an unrelated context was sufficient for inducing the fear memory specific to the conditioned context. In a further study, DG or CA1 neurons activated by exposure to a particular context were labelled with channelrhodopsin-2 (ChR2). These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context in which a foot shock was never delivered. The recall of this false memory was context specific, activated similar downstream regions engaged during natural fear-memory recall, and was also capable of driving an active fear response. Together, our data demonstrate that by substituting a natural conditioned stimulus with optogenetically reactivated DG cells that bear contextual memory engrams, it is possible to incept an internally and behaviourally represented false fear memory.

Inception of a false memory by optogenetic manipulation of a hippocampal memory engram

PubMed Central

Liu, Xu; Ramirez, Steve; Tonegawa, Susumu

2014-01-01

Memories can be easily distorted, and a lack of relevant animal models has largely hindered our understanding of false-memory formation. Here, we first identified a population of cells in the dentate gyrus (DG) of the hippocampus that bear the engrams for a specific context; these cells were naturally activated during the encoding phase of fear conditioning and their artificial reactivation using optogenetics in an unrelated context was sufficient for inducing the fear memory specific to the conditioned context. In a further study, DG or CA1 neurons activated by exposure to a particular context were labelled with channelrhodopsin-2 (ChR2). These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context in which a foot shock was never delivered. The recall of this false memory was context specific, activated similar downstream regions engaged during natural fear-memory recall, and was also capable of driving an active fear response. Together, our data demonstrate that by substituting a natural conditioned stimulus with optogenetically reactivated DG cells that bear contextual memory engrams, it is possible to incept an internally and behaviourally represented false fear memory. PMID:24298144

33 CFR 80.105 - Calais, ME to Cape Small, ME.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Calais, ME to Cape Small, ME. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.105 Calais, ME to Cape Small, ME... International Bridge at Calais, ME to the southwesternmost extremity of Bald Head at Cape Small. ...

33 CFR 80.105 - Calais, ME to Cape Small, ME.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Calais, ME to Cape Small, ME. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.105 Calais, ME to Cape Small, ME... International Bridge at Calais, ME to the southwesternmost extremity of Bald Head at Cape Small. ...

33 CFR 80.105 - Calais, ME to Cape Small, ME.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Calais, ME to Cape Small, ME. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.105 Calais, ME to Cape Small, ME... International Bridge at Calais, ME to the southwesternmost extremity of Bald Head at Cape Small. ...

33 CFR 80.105 - Calais, ME to Cape Small, ME.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Calais, ME to Cape Small, ME. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.105 Calais, ME to Cape Small, ME... International Bridge at Calais, ME to the southwesternmost extremity of Bald Head at Cape Small. ...

76 FR 23193 - Traffic Separation Schemes: In the Approaches to Portland, ME; Boston, MA; Narragansett Bay, RI...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

...-AB55 Traffic Separation Schemes: In the Approaches to Portland, ME; Boston, MA; Narragansett Bay, RI..., interim rule codifying traffic separation schemes in the approaches to Portland, ME; in the approaches to... Cape Fear River, NC, and updating the then-current regulations for the traffic separation scheme in the...

Creating a false memory in the hippocampus.

PubMed

Ramirez, Steve; Liu, Xu; Lin, Pei-Ann; Suh, Junghyup; Pignatelli, Michele; Redondo, Roger L; Ryan, Tomás J; Tonegawa, Susumu

2013-07-26

Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.

33 CFR 3.25-20 - Sector North Carolina Marine Inspection Zone and Captain of the Port Zone; Marine Safety Unit...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Inspection Zone and Captain of the Port Zone; Marine Safety Unit Wilmington: Cape Fear River Marine Inspection and Captain of the Port Zones. 3.25-20 Section 3.25-20 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AREAS, DISTRICTS, SECTORS, MARINE INSPECTION ZONES, AND...

Fluvial terraces of the Little River Valley, Atlantic Coastal Plain, North Carolina

Treesearch

Bradley Suther; David Leigh; George Brook

2011-01-01

An optically-stimulated luminescence (OSL) and radiocarbon chronology is presented for fluvial terraces of the Little River, a tributary to the Cape Fear River that drains 880 km2 of the Sandhills Province of the upper Coastal Plain of North Carolina. This study differs from previous work in the southeastern Atlantic Coastal Plain in that numerical age estimates are...

Triangle Area Water Supply Monitoring Project, North Carolina—Summary of monitoring activities, quality assurance, and data, October 2013–September 2015

USGS Publications Warehouse

Pfeifle, C.A.; Cain, J.L.; Rasmussen, R.B.

2017-09-27

Surface-water supplies are important sources of drinking water for residents in the Triangle area of North Carolina, which is located within the upper Cape Fear and Neuse River Basins. Since 1988, the U.S. Geological Survey and a consortium of local governments have tracked water-quality conditions and trends in several of the area’s water-supply lakes and streams. This report summarizes data collected through this cooperative effort, known as the Triangle Area Water Supply Monitoring Project, during October 2013 through September 2014 (water year 2014) and October 2014 through September 2015 (water year 2015). Major findings for this period include:More than 5,500 individual measurements of water quality were made at a total of 15 sites—4 in the Neuse River Basin and 11 in the Cape Fear River Basin. Thirty water-quality properties or constituents were measured; State water-quality thresholds exist for 11 of these.All observations met State water-quality thresholds for temperature, hardness, chloride, fluoride, sulfate, and nitrate plus nitrite.North Carolina water-quality thresholds were exceeded one or more times for dissolved oxygen, dissolved-oxygen percent saturation, pH, turbidity, and chlorophyll a.

Occurrence of Selected Pharmaceutical and Organic Wastewater Compounds in Effluent and Water Samples from Municipal Wastewater and Drinking-Water Treatment Facilities in the Tar and Cape Fear River Basins, North Carolina, 2003-2005

USGS Publications Warehouse

Ferrell, G.M.

2009-01-01

Samples of treated effluent and treated and untreated water were collected at 20 municipal wastewater and drinkingwater treatment facilities in the Tar and Cape Fear River basins of North Carolina during 2003 and 2005. The samples were analyzed for a variety of prescription and nonprescription pharmaceutical compounds and a suite of organic compounds considered indicative of wastewater. Concentrations of these compounds generally were less than or near the detection limits of the analytical methods used during this investigation. None of these compounds were detected at concentrations that exceeded drinking-water standards established by the U.S. Environmental Protection Agency. Bromoform, a disinfection byproduct, was the only compound detected at a concentration that exceeded regulatory guidelines. The concentration of bromoform in one finished drinking-water sample, 26 micrograms per liter, exceeded North Carolina water-quality criteria. Drinking-water treatment practices were effective at removing many of the compounds detected in untreated water. Disinfection processes used in wastewater treatment - chlorination or irradiation with ultraviolet light - did not seem to substantially degrade the organic compounds evaluated during this study.

Airborne radioactivity survey of parts of Atlantic Ocean beach, Virginia to Florida

USGS Publications Warehouse

Moxham, R.M.; Johnson, R.W.

1953-01-01

The accompanying maps show the results of an airborne radioactivity survey along the Atlantic Ocean beach from Cape Henry, Virginia to Cape Fear, North Carolina and from Savannah Bach Georgia to Miami Beach, Florida. The survey was made March 23-24, 1953, as part of a cooperative program with the U.S. Atomic Energy Commission. The survey was made with scintillation detection equipment mounted in a Douglas DC-3 aircraft and consisted of one flight line, at a 500-foot altitude, parallel to the beach. The vertical projection of the flight line coincided approximately with the landward limit of the modern beach. The width of the zone on the ground from which anomalous radiation is measured at the normal 500 foot flight altitude varies with the areal extent radioactivity of the source. For strong sources of radioactivity the width of the zone would be as much as 1,400 feet. The location of the flight lines is shown on the index map below. No abnormal radioactivity was detected along the northern flight line between Cape Henry, Virginia and Cape Fear, North Carolina. Along the southern flight line fourteen areas of abnormal radioactivity were detected between Savannah Beach, Georgia and Anastasia Island, Florida as shown on the map on the left. The abnormal radioactivity is apparently due to radioactive minerals associated with "black sand" deposits with occur locally along the beach in this region. The present technique of airborne radioactivity measurement does not permit distinguishing between activity sue to thorium and that due to uranium. An anomaly, therefore, may represent radioactivity due entirely to one or to a combination of these elements. It is not possible to determine the extent or radioactive content of the materials responsible for the abnormal radioactivity. The information given on the accompanying map indicates only those localities of greater-than-average radioactivity and, therefore suggest areas in which uranium and thorium deposits are more likely to occur.

33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

False recognition of facial expressions of emotion: causes and implications.

PubMed

Fernández-Dols, José-Miguel; Carrera, Pilar; Barchard, Kimberly A; Gacitua, Marta

2008-08-01

This article examines the importance of semantic processes in the recognition of emotional expressions, through a series of three studies on false recognition. The first study found a high frequency of false recognition of prototypical expressions of emotion when participants viewed slides and video clips of nonprototypical fearful and happy expressions. The second study tested whether semantic processes caused false recognition. The authors found that participants made significantly higher error rates when asked to detect expressions that corresponded to semantic labels than when asked to detect visual stimuli. Finally, given that previous research reported that false memories are less prevalent in younger children, the third study tested whether false recognition of prototypical expressions increased with age. The authors found that 67% of eight- to nine-year-old children reported nonpresent prototypical expressions of fear in a fearful context, but only 40% of 6- to 7-year-old children did so. Taken together, these three studies demonstrate the importance of semantic processes in the detection and categorization of prototypical emotional expressions.

46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

46 CFR 7.160 - Point Whitshed, AK to Aialik Cape, AK.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Point Whitshed, AK to Aialik Cape, AK. 7.160 Section 7.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.160 Point Whitshed, AK to Aialik Cape, AK. (a) A line drawn from the southernmost...

46 CFR 7.160 - Point Whitshed, AK to Aialik Cape, AK.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Point Whitshed, AK to Aialik Cape, AK. 7.160 Section 7.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.160 Point Whitshed, AK to Aialik Cape, AK. (a) A line drawn from the southernmost...

46 CFR 7.160 - Point Whitshed, AK to Aialik Cape, AK.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Point Whitshed, AK to Aialik Cape, AK. 7.160 Section 7.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.160 Point Whitshed, AK to Aialik Cape, AK. (a) A line drawn from the southernmost...

46 CFR 7.160 - Point Whitshed, AK to Aialik Cape, AK.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Point Whitshed, AK to Aialik Cape, AK. 7.160 Section 7.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.160 Point Whitshed, AK to Aialik Cape, AK. (a) A line drawn from the southernmost...

46 CFR 7.160 - Point Whitshed, AK to Aialik Cape, AK.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Point Whitshed, AK to Aialik Cape, AK. 7.160 Section 7.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.160 Point Whitshed, AK to Aialik Cape, AK. (a) A line drawn from the southernmost...

33 CFR 80.501 - Tom's River, NJ to Cape May, NJ.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Tom's River, NJ to Cape May, NJ. 80.501 Section 80.501 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Fifth District § 80.501 Tom's River, NJ to Cape May, NJ...

View of 'Cape Verde' from 'Cape St. Mary' in Mid-Afternoon (False Color)

NASA Technical Reports Server (NTRS)

2006-01-01

As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a promontory called 'Cape Verde' from the vantage point of 'Cape St. Mary,' the next promontory clockwise around the crater's deeply scalloped rim. This view of Cape Verde combines several exposures taken by the rover's panoramic camera into an approximately false-color mosaic. The exposures were taken during mid-afternoon lighting conditions.

The upper portion of the crater wall contains a jumble of material tossed outward by the impact that excavated the crater. This vertical cross-section through the blanket of ejected material surrounding the crater was exposed by erosion that expanded the crater outward from its original diameter, according to scientists' interpretation of the observations. Below the jumbled material in the upper part of the wall are layers that survive relatively intact from before the crater-causing impact.

The images combined into this mosaic were taken during the 1,006th Martian day, or sol, of Opportunity's Mars-surface mission (Nov. 22, 2006). The panoramic camera took them through the camera's 750-nanometer, 530-nanometer and 430-nanometer filters. The false color enhances subtle color differences among materials in the rocks and soils of the scene.

View of 'Cape Verde' from 'Cape St. Mary' in Late Morning (False Color)

NASA Technical Reports Server (NTRS)

2006-01-01

As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a promontory called 'Cape Verde' from the vantage point of 'Cape St. Mary,' the next promontory clockwise around the crater's deeply scalloped rim. This view of Cape Verde combines several exposures taken by the rover's panoramic camera into a false-color mosaic. The exposures were taken during late-morning lighting conditions.

The upper portion of the crater wall contains a jumble of material tossed outward by the impact that excavated the crater. This vertical cross-section through the blanket of ejected material surrounding the crater was exposed by erosion that expanded the crater outward from its original diameter, according to scientists' interpretation of the observations. Below the jumbled material in the upper part of the wall are layers that survive relatively intact from before the crater-causing impact.

The images combined into this mosaic were taken during the 1,006th Martian day, or sol, of Opportunity's Mars-surface mission (Nov. 22, 2006). The panoramic camera took them through the camera's 750-nanometer, 530-nanometer and 430-nanometer filters. The false color enhances subtle color differences among materials in the rocks and soils of the scene.

Earth observations Cape Town, South Africa taken during the STS-97 mission

NASA Image and Video Library

2000-12-10

STS097-711-069 (30 Nov. - 11 Dec. 2000) This view featuring Cape Town and the Western Cape Province in the Republic of South Africa was provided by one of the STS-97 astronauts using a 70mm handheld camera aboard the Earth-orbiting Space Shuttle Endeavour. The capital and largest city of Western Cape Province, Cape Town (1995 population in the urban and suburban area shows in excess of 1.9 million), is visible between False Bay (large, U-shaped bay) and a smaller bay along the Atlantic coast of the peninsula. Within the urban built-up area some of the infrastructure of Cape Town, including the city center and the harbor and waterfront facilities, can be identified near the small bay (middle left edge of the image). Table Mountain elevation of 3563 feet (1086 meters above sea level) separates the city center (north of the mountain) from the southern suburbs of Cape Town. The Cape of Good Hope, long famous as the gateway from the Atlantic Ocean to the Indian Ocean, is located at the southern tip of the claw-shaped peninsula. False Bay is a popular recreational region for the local residents of the greater Cape Town region, as well as a tourist attraction for people who live beyond the borders of South Africa. The lighter-colored terrain, mainly north of Cape Town, shows a landscape of large, cultivated field patterns. These coastal plains are separated from the interior by a chain of folded mountain ranges that include the Cedarberg (dark, linear, north/south aligned feature in the upper right corner) and the more complex, folded Herrivierberge Mountains (dark structure, right middle) that are located northeast of Cape Town.

Selected papers in the hydrologic sciences, 1986

USGS Publications Warehouse

Subitzky, Seymour

1987-01-01

Water-quality data from long-term (24 years), fixed- station monitoring at the Cape Fear River at Lock 1 near Kelly, N.C., and various measures of basin development are correlated. Subbasin population, number of acres of cropland in the subbasin, number of people employed in manufacturing, and tons of fertilizer applied in the basin are considered as measures of basinwide development activity. Linear correlations show statistically significant posi- tive relations between both population and manufacturing activity and most of the dissolved constituents considered. Negative correlations were found between the acres of harvested cropland and most of the water-quality measures. The amount of fertilizer sold in the subbasin was not statistically related to the water-quality measures considered in this report. The statistical analysis was limited to several commonly used measures of water quality including specific conductance, pH, dissolved solids, several major dissolved ions, and a few nutrients. The major dissolved ions included in the analysis were calcium, sodium, potassium, magnesium, chloride, sulfate, silica, bicarbonate, and fluoride. The nutrients included were dissolved nitrite plus nitrate nitrogen, dissolved ammonia nitrogen, total nitrogen, dissolved phosphates, and total phosphorus. For the chemicals evaluated, manufacturing and population sources are more closely associated with water quality in the Cape Fear River at Lock 1 than are agricultural variables.

View of 'Cape St. Mary' from 'Cape Verde' (False Color)

NASA Technical Reports Server (NTRS)

2006-01-01

As part of its investigation of 'Victoria Crater,' NASA's Mars Exploration Rover Opportunity examined a promontory called 'Cape St. Mary' from the from the vantage point of 'Cape Verde,' the next promontory counterclockwise around the crater's deeply scalloped rim. This view of Cape St. Mary combines several exposures taken by the rover's panoramic camera into a false-color mosaic. Contrast has been adjusted to improve the visibility of details in shaded areas.

The upper portion of the crater wall contains a jumble of material tossed outward by the impact that excavated the crater. This vertical cross-section through the blanket of ejected material surrounding the crater was exposed by erosion that expanded the crater outward from its original diameter, according to scientists' interpretation of the observations. Below the jumbled material in the upper part of the wall are layers that survive relatively intact from before the crater-causing impact. Near the base of the Cape St. Mary cliff are layers with a pattern called 'crossbedding,' intersecting with each other at angles, rather than parallel to each other. Large-scale crossbedding can result from material being deposited as wind-blown dunes.

The images combined into this mosaic were taken during the 970th Martian day, or sol, of Opportunity's Mars-surface mission (Oct. 16, 2006). The panoramic camera took them through the camera's 750-nanometer, 530-nanometer and 430-nanometer filters. The false color enhances subtle color differences among materials in the rocks and soils of the scene.

Women's Fear of Violence in the Wilderness.

ERIC Educational Resources Information Center

Day, Tobin; Potter, Tom G.

1999-01-01

Seven female students in an outdoor-recreation program were interviewed to determine how fear of violence affects experienced female wilderness travelers. The themes that emerged were stereotypes about sexual assaults, situation and trip location, and alcohol consumption. The difference between real fear and false perceptions is discussed, along…

33 CFR 334.100 - Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range. 334.100 Section 334.100 Navigation and Navigable Waters CORPS OF ENGINEERS... Ocean off Cape May, N.J.; Coast Guard Rifle Range. (a) The danger zone. The waters of the Atlantic Ocean...

33 CFR 334.100 - Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range. 334.100 Section 334.100 Navigation and Navigable Waters CORPS OF ENGINEERS... Ocean off Cape May, N.J.; Coast Guard Rifle Range. (a) The danger zone. The waters of the Atlantic Ocean...

33 CFR 334.100 - Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range. 334.100 Section 334.100 Navigation and Navigable Waters CORPS OF ENGINEERS... Ocean off Cape May, N.J.; Coast Guard Rifle Range. (a) The danger zone. The waters of the Atlantic Ocean...

33 CFR 334.100 - Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range. 334.100 Section 334.100 Navigation and Navigable Waters CORPS OF ENGINEERS... Ocean off Cape May, N.J.; Coast Guard Rifle Range. (a) The danger zone. The waters of the Atlantic Ocean...

33 CFR 334.100 - Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Atlantic Ocean off Cape May, N.J.; Coast Guard Rifle Range. 334.100 Section 334.100 Navigation and Navigable Waters CORPS OF ENGINEERS... Ocean off Cape May, N.J.; Coast Guard Rifle Range. (a) The danger zone. The waters of the Atlantic Ocean...

33 CFR 334.20 - Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. 334.20 Section 334.20 Navigation and Navigable Waters... REGULATIONS § 334.20 Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. (a) The...

33 CFR 334.20 - Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. 334.20 Section 334.20 Navigation and Navigable Waters... REGULATIONS § 334.20 Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. (a) The...

33 CFR 334.20 - Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. 334.20 Section 334.20 Navigation and Navigable Waters... REGULATIONS § 334.20 Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. (a) The...

33 CFR 334.20 - Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. 334.20 Section 334.20 Navigation and Navigable Waters... REGULATIONS § 334.20 Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. (a) The...

33 CFR 334.20 - Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. 334.20 Section 334.20 Navigation and Navigable Waters... REGULATIONS § 334.20 Gulf of Maine off Cape Small, Maine; naval aircraft practice mining range area. (a) The...

33 CFR 207.610 - St. Lawrence River, Cape Vincent Harbor, N.Y.; use, administration, and navigation of the harbor...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Lawrence River, Cape Vincent Harbor, N.Y.; use, administration, and navigation of the harbor and U.S. breakwater. 207.610 Section 207... NAVIGATION REGULATIONS § 207.610 St. Lawrence River, Cape Vincent Harbor, N.Y.; use, administration, and...

46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to Cape...

46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to Cape...

46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to Cape...

46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to Cape...

46 CFR 7.150 - Canadian (BC) and United States (AK) Borders to Cape Spencer, AK.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Canadian (BC) and United States (AK) Borders to Cape Spencer, AK. 7.150 Section 7.150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.150 Canadian (BC) and United States (AK) Borders to Cape...

Cape Town, South Africa, Perspective View, Landsat Image over SRTM Elevation

NASA Technical Reports Server (NTRS)

2004-01-01

Cape Town and the Cape of Good Hope, South Africa, appear in the foreground of this perspective view generated from a Landsat satellite image and elevation data from the Shuttle Radar Topography Mission (SRTM). The city center is located at Table Bay (at the lower left), adjacent to Table Mountain, a 1,086-meter (3,563-foot) tall sandstone and granite natural landmark.

Cape Town enjoys a Mediterranean climate but must deal with the limited water supply characteristic of that climate. Until the 1890s the city relied upon streams and springs along the base of Table Mountain, then built a small reservoir atop Table Mountain to capture and store rainfall there. Now the needs of a much larger population are met in part by much larger reservoirs such as seen here far inland (mid-distance left) at the Theewaterskloof Dam.

False Bay is the large bay to the south (right) of Cape Town, just around the Cape of Good Hope. It is one of the largest bays along the entire South African coast, but nearby Cape Town has its harbor at Table Bay. False Bay got its name because mariners approaching Cape Town from the east would see the prominent bay and falsely assume it to be the entrance to Cape Town harbor. Similarly, people often mistake the Cape of Good Hope as the southernmost point of Africa. But the southernmost point is actually Cape Agulhas, located just to the southeast (upper right) of this scene.

This Landsat and SRTM perspective view uses a 2-times vertical exaggeration to enhance topographic expression. The back edges of the data sets form a false horizon and a false sky was added. Colors of the scene were enhanced by image processing but are the natural color band combination from the Landsat satellite.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between the National Aeronautics and Space Administration (NASA), the National Geospatial-Intelligence Agency (NGA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

View Size: 66 kilometers (41 miles) wide by 134 kilometers (83 miles) distance Location: 34.2 degrees South latitude, 18.7 degrees East longitude Orientation: View toward east-southeast Image Data: Landsat Bands 1, 2, 3 in blue, green, red Date Acquired: February 2000 (SRTM), June 13, 2000 (Landsat)

33 CFR 117.829 - Northeast Cape Fear River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... will operate as follows: (1) The draw will be closed to pleasure craft from 6 a.m. to 6 p.m. every day... signal from 6 p.m. to 6 a.m. (4) From 8 a.m. to 10 a.m. on the second Saturday of July of every year, and from 7 a.m. to 11 a.m. on the second Sunday of November of every year, the draw need not open for...

A baby owl is found at CCAFS

NASA Technical Reports Server (NTRS)

2000-01-01

A baby owl, possibly a screech owl, shows its fear and resentment of the photographer snapping its picture. The owl was found on the stairs inside Hangar G, Cape Canaveral Air Force Station. It had apparently tried to fly from a nest near the ceiling but couldn't get back to it. Workers called an Audubon rescue center near Orlando, which captured it and will ensure the bird is returned to the wild when it's ready.

False Context Fear Memory in Rats

ERIC Educational Resources Information Center

Bae, Sarah; Holmes, Nathan M.; Westbrook, R. Frederick

2015-01-01

Four experiments used rats to study false context fear memories. In Experiment 1, rats were pre-exposed to a distinctive chamber (context A) or to a control environment (context C), shocked after a delay in a second chamber (context B) and tested either in B or A. Rats pre-exposed to A froze just as much as control rats in B but more than control…

KSC00padig008

NASA Image and Video Library

2000-03-28

KENNEDY SPACE CENTER, FLA. -- A baby owl, possibly a screech owl, shows its fear and resentment of the photographer snapping its picture. The owl was found on the stairs inside Hangar G, Cape Canaveral Air Force Station. It had apparently tried to fly from a nest near the ceiling but couldn't get back to it. Workers called an Audubon rescue center near Orlando, which captured it and will ensure the bird is returned to the wild when it's ready

KSC-00padig008

NASA Image and Video Library

2000-03-28

KENNEDY SPACE CENTER, FLA. -- A baby owl, possibly a screech owl, shows its fear and resentment of the photographer snapping its picture. The owl was found on the stairs inside Hangar G, Cape Canaveral Air Force Station. It had apparently tried to fly from a nest near the ceiling but couldn't get back to it. Workers called an Audubon rescue center near Orlando, which captured it and will ensure the bird is returned to the wild when it's ready

Water-level conditions in the Black Creek and upper Cape Fear aquifers, 1992, in parts of Bladen and Robeson counties, North Carolina

USGS Publications Warehouse

Strickland, Alfred Gerald

1994-01-01

Water-level measurements were made in 68 wells throughout an area of about 860 square miles in Bladen and Robeson Counties, North Carolina, during September and October 1992. Water levels from 58 wells were used to determine the configuration of the potentiometric surface of the Black Creek aquifer. A map of the potentiometric surface shows the potential for ground water to flow from recharge areas in the local uplands to discharge areas, such as local streams and wells. Pumping from wells at major pumping centers, such as Elizabethtown in Bladen County and Lumberton in Robeson County, where water-level declines of more than 12 feet were recorded from 1988 to 1992, has resulted in cones of depression in the potentiometric surface. The cones were about 4 and 6 miles long across the major axes beneath the Elizabethtown and Lumberton areas, respectively, in 1992. Water levels measured in eight wells in 1988 and 1992, supplemented with water levels in two additional wells from driller's well- construction records, were used to estimate average yearly rates of ground-water change for the upper Cape Fear aquifer for part of the study area. During 1988-92, water-level declines occurred in the aquifer throughout much of the area as a result of pumping. The greatest decline, an average of 4.1 feet per year, was in Bladen County.

A numerical study of the plume in Cape Fear River Estuary and adjacent coastal ocean

NASA Astrophysics Data System (ADS)

Xia, M.; Xia, L.; Pietrafesa, L. J.

2006-12-01

Cape Fear River Estuary (CFRE), located in southeast North Carolina, is the only river estuary system in the state which is directly connected to the Atlantic Ocean. It is also an important nursery for economically and ecologically important juvenile fish, crabs, shrimp, and other species because of the tidal influence and saline waters. In this study, Environmental Fluid Dynamic Code (EFDC) is used to simulate the salinity plume and trajectory distribution at the mouth of the CFRE and adjacent coastal ocean. Prescribed with the climatological freshwater discharge rates in the rivers, the modeling system was used to simulate the salinity plume and trajectory distribution distribution in the mouth of the CFRE under the influence of climatological wind conditions and tidal effect. We analyzed the plume formation processes and the strong relationship between the various plume distributions with respect to the wind and river discharge in the region. The simulations also indicate that strong winds tend to reduce the surface CFRE plume size and distorting the bulge region near the estuary mouth due to enhanced wind induced surface mixing. Even moderate wind speeds could fully reverse the buoyancy-driven plume structure in CFRE under normal river discharge conditions. Tide and the river discharge also are important factors to influence the plume structure. The comparions between the distribution of salinity plume and trajectory also are discussed in the study.

Biogeochemical alteration of dissolved organic material in the Cape Fear River Estuary as a function of freshwater discharge

NASA Astrophysics Data System (ADS)

Dixon, Jennifer L.; Helms, John R.; Kieber, Robert J.; Avery, G. Brooks

2014-08-01

This study presents the first extensive examination of the controls on optical properties of chromophoric dissolved organic matter (CDOM) within the Cape Fear River Estuary (CFRE) utilizing spectral slope ratios (SR). The application of SUVA254 values, absorption spectral slopes (S) and SR values has presented a distinct opportunity to observe compositional changes in CDOM in the CFRE that was not possible using bulk DOC and aCDOM(350) values alone. By comparing estuarine trends in CDOM spectral shape during both normal and historically low flow conditions, we found that diagenetic processing of CDOM in the CFRE is controlled primarily by riverine discharge rates. These findings suggest that the chromophoric fraction of DOM is altered during estuarine transport under low flow regimes but reaches the coastal ocean relatively unaltered under higher flow conditions. This highlights the tendency for autochthonous sources of DOC to offset photochemical losses and indicates that in situ DOC production can significantly contribute to the overall carbon load if discharge is low or sufficient biogeochemical alteration of the terrestrial DOM end-member occurs. This provides new insight into the usefulness of these optical properties into understanding the cycling, fate and transport of CDOM to the coastal ocean. SR values provide a simple but potentially powerful tool in understanding the flux, transport and impact of terrestrially derived organic material deposited in the coastal ocean.

10 CFR 708.6 - What constitutes “a reasonable fear of serious injury?”

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false What constitutes âa reasonable fear of serious injury?â 708.6 Section 708.6 Energy DEPARTMENT OF ENERGY DOE CONTRACTOR EMPLOYEE PROTECTION PROGRAM General Provisions § 708.6 What constitutes “a reasonable fear of serious injury?” Participation in an activity...

46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6” to latitude 36°36.5′ N. longitude 121°53.2′ W. (Monterey Harbor Anchorage Buoy “A”); thence to the... 46 Shipping 1 2010-10-01 2010-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135...

46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6” to latitude 36°36.5′ N. longitude 121°53.2′ W. (Monterey Harbor Anchorage Buoy “A”); thence to the... 46 Shipping 1 2014-10-01 2014-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135...

46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6” to latitude 36°36.5′ N. longitude 121°53.2′ W. (Monterey Harbor Anchorage Buoy “A”); thence to the... 46 Shipping 1 2013-10-01 2013-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135...

46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6” to latitude 36°36.5′ N. longitude 121°53.2′ W. (Monterey Harbor Anchorage Buoy “A”); thence to the... 46 Shipping 1 2012-10-01 2012-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135...

36 CFR 27.2 - Commercial and industrial activities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Commercial and industrial... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore. ...

GenX (FRD-902, ammonium (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) Does Not Display Estrogenic, (anti)androgenic or Glucocorticoid-like Activity In Vitro Whereas In Utero Exposure Induces Dose-related Maternal And Fetal Rat Liver PPAR Pathway Gene Expression Without Affecting Fetal Testis Testosterone Production.

EPA Science Inventory

GenX (CAS 13252-13-6) is an unregulated, persistent contaminant that has been found in both the Cape Fear River and in Wilmington NC drinking water. Concerns exist about the potential health effects of GenX exposure because it is not removed using traditional water treatment met...

Low-flow characteristics and profiles for the Deep River in the Cape Fear River basin, North Carolina

USGS Publications Warehouse

Weaver, J.C.

1997-01-01

Drainage area and low-flow discharge profiles are presented for the Deep River. The drainage-area profile shows downstream increases in basin size. At the mouth, the drainage area for the Deep River is 1,441 square miles. Low-flow discharge profiles for the Deep River include 7Q10, 30Q2, W7Q10, and 7Q2 discharges in a continuous profile with contributions from major tributaries included.

Water mass linkages between the Middle and South Atlantic bights

NASA Astrophysics Data System (ADS)

Pietrafesa, L. J.; Morrison, J. M.; McCann, M. P.; Churchill, J.; Böhm, E.; Houghton, R. W.

Time and frequency domain analyses are used to relate coastal meteorological data with 7 years of daily surface temperature and salinity collected at three coastal light stations; offshore of the mouth of Chesapeake Bay, Virginia, on Diamond Shoals, at Cape Hatteras, North Carolina and on Frying Pan Shoals, off Cape Fear, North Carolina. Salinity fluctuations at Diamond Shoals are highly correlated with alongshore wind stress, implying wind driven advection of the front between Virginia Coastal Water (VCW) and Carolina Coastal Water (CCW) across Diamond Shoals. The data collected at Diamond Shoals indicate that more than half the time there is significant encroachment of Mid Atlantic Bight water into the South Atlantic Bight around Cape Hatteras, contrary to the notion that VCW is entirely entrained into the Gulf Stream. In fact, VCW can appear as far south as Frying Pan Shoals, thereby extending across the entire North Carolina Capes inner to mid shelf. Temperature and salinity time series also indicate that water masses overlying Diamond Shoals respond quickly to cross-shelf winds. Cross-shelf wind stress is significantly correlated with surface water temperature at Diamond Shoals, for periods between 2 and 12 days. Changes in temperature can be brought about by wind-driven cross-shelf circulation and by wind-induced upwelling. Seasurface temperature satellite (AVHRR) imagery taken during the SEEP II confirm these concepts.

Panorama from 'Cape Verde' (False Color)

NASA Technical Reports Server (NTRS)

2007-01-01

NASA's Mars Exploration Rover Opportunity captured this vista of 'Victoria Crater' from the viewpoint of 'Cape Verde,' one of the promontories that are part of the scalloped rim of the crater. Opportunity drove onto Cape Verde shortly after arriving at the rim of Victoria in September 2006. The view combines hundreds of exposures taken by the rover's panoramic camera (Pancam). The camera began taking the component images during Opportunity's 970th Martian day, or sol, on Mars (Oct. 16, 2006). Work on the panorama continued through the solar conjunction period, when Mars was nearly behind the sun from Earth's perspective and communications were minimized. Acquisition of images for this panorama was completed on Opportunity's 991st sol (Nov. 7, 2006).

The top of Cape Verde is in the immediate foreground at the center of the image. To the left and right are two of the more gradually sloped bays that alternate with the cliff-faced capes or promontories around the rim of the crater. 'Duck Bay,' where Opportunity first reached the rim, is to the right. Beyond Duck Bay counterclockwise around the rim, the next promontory is 'Cabo Frio,' about 150 meters (500 feet) from the rover. On the left side of the panorama is 'Cape St. Mary,' the next promontory clockwise from Cape Verde and about 40 meters (130 feet) from the rover. The vantage point atop Cape Verde offered a good view of the rock layers in the cliff face of Cape St. Mary, which is about 15 meters or 50 feet tall. By about two weeks after the Pancam finished collecting the images for this panorama, Opportunity had driven to Cape St. Mary and was photographing Cape Verde's rock layers.

The far side of the crater lies about 800 meters (half a mile) away, toward the southeast.

This view combines images taken through three of the Pancam's filters, admitting light with wavelengths centered at 750 nanometers (near infrared), 530 nanometers (green) and 430 nanometers (violet). It is presented in false color to emphasize differences among materials in the rocks and soils.

33 CFR 80.805 - Rock Island, FL to Cape San Blas, FL.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Rock Island, FL to Cape San Blas, FL. 80.805 Section 80.805 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.805 Rock Island, FL...

33 CFR 80.805 - Rock Island, FL to Cape San Blas, FL.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Rock Island, FL to Cape San Blas, FL. 80.805 Section 80.805 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.805 Rock Island, FL...

33 CFR 80.805 - Rock Island, FL to Cape San Blas, FL.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Rock Island, FL to Cape San Blas, FL. 80.805 Section 80.805 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.805 Rock Island, FL...

33 CFR 80.805 - Rock Island, FL to Cape San Blas, FL.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Rock Island, FL to Cape San Blas, FL. 80.805 Section 80.805 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.805 Rock Island, FL...

33 CFR 80.805 - Rock Island, FL to Cape San Blas, FL.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Rock Island, FL to Cape San Blas, FL. 80.805 Section 80.805 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Eighth District § 80.805 Rock Island, FL...

33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

36 CFR 7.49 - Cape Lookout National Seashore.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Cape Lookout National Seashore. 7.49 Section 7.49 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... conditions: (1) PWC must be operated at flat-wake speed; (2) PWC must travel perpendicular to shore; (3) PWC...

36 CFR 7.49 - Cape Lookout National Seashore.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Cape Lookout National Seashore. 7.49 Section 7.49 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... conditions: (1) PWC must be operated at flat-wake speed; (2) PWC must travel perpendicular to shore; (3) PWC...

36 CFR 7.49 - Cape Lookout National Seashore.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Cape Lookout National Seashore. 7.49 Section 7.49 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... conditions: (1) PWC must be operated at flat-wake speed; (2) PWC must travel perpendicular to shore; (3) PWC...

36 CFR 7.49 - Cape Lookout National Seashore.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Cape Lookout National Seashore. 7.49 Section 7.49 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... conditions: (1) PWC must be operated at flat-wake speed; (2) PWC must travel perpendicular to shore; (3) PWC...

36 CFR 7.49 - Cape Lookout National Seashore.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Cape Lookout National Seashore. 7.49 Section 7.49 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... conditions: (1) PWC must be operated at flat-wake speed; (2) PWC must travel perpendicular to shore; (3) PWC...

Evidence of Extensive Gas Venting at the Blake Ridge and Cape Fear Diapirs

NASA Astrophysics Data System (ADS)

Brothers, L.; Van Dover, C. L.; German, C. R.; Yoerger, D. R.; Kaiser, C. L.; Lobecker, M.; Skarke, A. D.; Ruppel, C. D.

2012-12-01

Despite the important geologic, geotechnical and biogeochemical implications of seabed fluid escape, the abundance and global distribution of cold seeps remain poorly characterized. Globally, seabed fluid escape is sometimes associated with chemosynthetic communities. Fluid escape on continental margins has also been invoked as a possible trigger for submarine slope failures and seafloor collapse. Along the U.S. Atlantic Margin, acoustic and geochemical water column anomalies have been observed in the Hudson Canyon, the mid-Atlantic shelf break, and the Blake Ridge Diapir (ODP Leg 164 site 996). Of these areas, only the Blake Ridge Diapir site is known to host chemosynthetic communities, a strong seafloor indicator of active seabed fluid flow. In July 2012, NOAA Ocean Exploration Program expedition EX1205L1 identified and characterized cold seeps within the Blake Ridge gas hydrate province, using the platform Okeanos Explorer and the Autonomous Underwater Vehicle (AUV) Sentry. The expedition observed seven spatially distinct water column anomalies using shipboard EM302 30 kHz multibeam and EK60 18 kHz single beam echosounders. These anomalies originate at the seabed and extend up to 900 m above the seafloor. Interpreted as bubble plumes, these anomalies correspond in six locations to Sentry-collected photos documenting chemosynthetic organisms (e.g. mussels and clams). Three plumes are associated with the known Blake Ridge Diapir seep site, while two additional plumes and newly discovered seep communities occur within 2 km of the original site. For the first time, a gas plume and associated seep community were also observed on the main Cape Fear Diapir. Co-located 3.5 kHz subbottom data, including lines that re-occupy a 3D survey conducted in 2003 across the Blake Ridge Diapir (doi:10.1029/2006GL028859), reveal subsurface conduits presently associated with these seeps and should allow us to constrain the plumbing systems in two and three dimensions. No methane seeps were found along 210 km of surveys conducted at the presumed upper edge of gas hydrate stability on the continental slope between Blake Ridge and the head of the Cape Fear slide. Nonetheless, the discovery of new seeps indicates abundant active methane escape along the southern portion of the US Atlantic Margin and calls for a reevaluation of the role of methane venting in regional seafloor processes there. In addition, these results triple the number of known cold seep communities along the US Atlantic margin, thus providing insight into biogeographic connectivity.

33 CFR 165.777 - Security Zone; West Basin, Port Canaveral Harbor, Cape Canaveral, Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... clearly states the location of the security zone and the times it will be enforced. This will be the... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; West Basin, Port... Guard District § 165.777 Security Zone; West Basin, Port Canaveral Harbor, Cape Canaveral, Florida. (a...

33 CFR 80.748 - Cape Romano, FL to Sanibel Island, FL.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Romano, FL to Sanibel Island... Sanibel Island, FL. (a) A line drawn across Big Marco Pass parallel to the general trend of the seaward, highwater shoreline. (b) A line drawn from the northwesternmost extremity of Coconut Island 000°T across...

33 CFR 80.748 - Cape Romano, FL to Sanibel Island, FL.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Romano, FL to Sanibel Island... Sanibel Island, FL. (a) A line drawn across Big Marco Pass parallel to the general trend of the seaward, highwater shoreline. (b) A line drawn from the northwesternmost extremity of Coconut Island 000°T across...

33 CFR 80.748 - Cape Romano, FL to Sanibel Island, FL.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Romano, FL to Sanibel Island... Sanibel Island, FL. (a) A line drawn across Big Marco Pass parallel to the general trend of the seaward, highwater shoreline. (b) A line drawn from the northwesternmost extremity of Coconut Island 000°T across...

33 CFR 80.748 - Cape Romano, FL to Sanibel Island, FL.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Romano, FL to Sanibel Island... Sanibel Island, FL. (a) A line drawn across Big Marco Pass parallel to the general trend of the seaward, highwater shoreline. (b) A line drawn from the northwesternmost extremity of Coconut Island 000°T across...

33 CFR 80.748 - Cape Romano, FL to Sanibel Island, FL.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Romano, FL to Sanibel Island... Sanibel Island, FL. (a) A line drawn across Big Marco Pass parallel to the general trend of the seaward, highwater shoreline. (b) A line drawn from the northwesternmost extremity of Coconut Island 000°T across...

33 CFR 165.535 - Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone: Atlantic Ocean... Guard District § 165.535 Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware. (a) Location. The following area is a safety zone: All waters of the Atlantic Ocean within the area bounded by...

33 CFR 165.535 - Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: Atlantic Ocean... Guard District § 165.535 Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware. (a) Location. The following area is a safety zone: All waters of the Atlantic Ocean within the area bounded by...

33 CFR 165.535 - Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone: Atlantic Ocean... Guard District § 165.535 Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware. (a) Location. The following area is a safety zone: All waters of the Atlantic Ocean within the area bounded by...

33 CFR 165.535 - Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: Atlantic Ocean... Guard District § 165.535 Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware. (a) Location. The following area is a safety zone: All waters of the Atlantic Ocean within the area bounded by...

33 CFR 165.535 - Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone: Atlantic Ocean... Guard District § 165.535 Safety Zone: Atlantic Ocean, Vicinity of Cape Henlopen State Park, Delaware. (a) Location. The following area is a safety zone: All waters of the Atlantic Ocean within the area bounded by...

The Collins Creek and Pleasant Creek Formations: Two new upper cretaceous subsurface units in the Carolina/Georgia Coastal Plain

USGS Publications Warehouse

,; Prowell, D.C.; Christopher, R.A.

2004-01-01

This paper formally defines two new Upper Cretaceous subsurface units in the southern Atlantic Coastal Plain of North Carolina, South Carolina and Georgia: the Collins Creek Formation and the Pleasant Creek Formation. These units are confined to the subsurface of the outer Coastal Plain, and their type sections are established in corehole CHN-820 from Charleston County, S.C. The Collins Creek Formation consists of greenish-gray lignitic sand and dark-greenish-gray sandy clay and is documented in cores from Allendale, Beaufort, Berkeley, Dorchester, Jasper and Marion Counties, South Carolina, and from Screven County, Georgia. Previously, Collins Creek strata had been incorrectly assigned to the Middendorf Formation. These sediments occupy a stratigraphic position between the Turonian/Coniacian Cape Fear Formation (?) below and the proposed upper Coniacian to middle Santonian Pleasant Creek Formation above. The Collins Creek Formation is middle and late Coniacian in age on the basis of calcareous nannofossil and palynomorph analyses. The Pleasant Creek Formation consists of olive-gray sand and dark-greenish-gray silty to sandy clay and is documented in cores from New Hanover County, North Carolina, and Berkeley, Charleston, Dorchester, Horry and Marion Counties, South Carolina. The strata of this unit previously were assigned incorrectly to the Middendorf Formation and (or) the Cape Fear Formation. These sediments occupy a stratigraphic position between the proposed Collins Creek Formation below and the Shepherd Grove Formation above. The Pleasant Creek Formation is late Coniacian and middle Santonian in age, on the basis of its calcareous nannofossil and palynomorph assemblages.

Making unhealthy places: The built environment and non-communicable diseases in Khayelitsha, Cape Town.

PubMed

Smit, Warren; de Lannoy, Ariane; Dover, Robert V H; Lambert, Estelle V; Levitt, Naomi; Watson, Vanessa

2016-05-01

In this paper, we examine how economic, social and political forces impact on NCDs in Khayelitsha (a predominantly low income area in Cape Town, South Africa) through their shaping of the built environment. The paper draws on literature reviews and ethnographic fieldwork undertaken in Khayelitsha. The three main pathways through which the built environment of the area impacts on NCDs are through a complex food environment in which it is difficult to achieve food security, an environment that is not conducive to safe physical activity, and high levels of depression and stress (linked to, amongst other factors, poverty, crime and fear of crime). All of these factors are at least partially linked to the isolated, segregated and monofunctional nature of Khayelitsha. The paper highlights that in order to effectively address urban health challenges, we need to understand how economic, social and political forces impact on NCDs through the way they shape built environments. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Who Cares? Pre and Post Abortion Experiences among Young Females in Cape Coast Metropolis, Ghana.

PubMed

Esia-Donkoh, Kobina; Darteh, Eugene K M; Blemano, Harriet; Asare, Hagar

2015-06-01

Issues of abortion are critical in Ghana largely due to its consequences on sexual and reproductive health. The negative perception society attaches to it makes it difficult for young females to access services and share their experiences. This paper examines the pre and post abortion experiences of young females; a subject scarcely researched in the country. Twenty-one clients of Planned Parenthood Association of Ghana (PPAG) clinic at Cape Coast were interviewed. Guided by the biopsychosocial model, the study revealed that fear of societal stigma, shame, and rejection by partners, as well as self-imposed stigma constituted some of the pre and post abortion experiences the respondents. Other experiences reported were bleeding, severe abdominal pain and psychological pain. The Ghana Health Services (GHS) and other service providers should partner the PPAG clinic to integrate psychosocial treatment in its abortion services while intensifying behaviour change communication and community-based stigma-reduction education in the Metropolis.

Cape Town, South Africa, Anaglyph, Landsat Image over SRTM Elevation

NASA Technical Reports Server (NTRS)

2004-01-01

Cape Town and the Cape of Good Hope, South Africa, appear on the left (west) of this anaglyph view generated from a Landsat satellite image and elevation data from the Shuttle Radar Topography Mission (SRTM). The city center is located between Table Bay (upper left) and Table Mountain (just to the south), a 1,086-meter (3,563-foot) tall sandstone and granite natural landmark.

Cape Town enjoys a Mediterranean climate but must deal with the limited water supply characteristic of that climate. Until the 1890s the city relied upon streams and springs along the base of Table Mountain, then built a small reservoir atop Table Mountain to capture and store rainfall there (visible in this anaglyph when viewed at full resolution). Now the needs of a much larger population are met in part by much larger reservoirs such as seen well inland (upper right) at the Theewaterskloof Dam.

False Bay is the large bay to the southeast (lower right) of Cape Town, just around the Cape of Good Hope. It is one of the largest bays along the entire South African coast, but nearby Cape Town has its harbor at Table Bay. False Bay got its name because mariners approaching Cape Town from the east would see the prominent bay and falsely assume it to be the entrance to Cape Town harbor. Similarly, people often mistake the Cape of Good Hope as the southernmost point of Africa. But the southernmost point is actually Cape Agulhas, located just to the southeast (lower right) of this scene.

This anaglyph was created by draping a Landsat visible light image over an SRTM elevation model, and then generating two differing perspectives, one for each eye. When viewed through special glasses, the anaglyph is a vertically exaggerated view of the Earth's surface in its full three dimensions. Anaglyph glasses cover the left eye with a red filter and cover the right eye with a blue filter.

Elevation data used in this image was acquired by the Shuttle Radar Topography Mission (SRTM) aboard the Space Shuttle Endeavour, launched on February 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between the National Aeronautics and Space Administration (NASA), the National Geospatial-Intelligence Agency (NGA) of the U.S. Department of Defense (DoD), and the German and Italian space agencies. It is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Earth Science Enterprise, Washington, D.C.

View Size: 66 kilometers (41 miles) by 134 kilometers (83 miles) Location: 34.2 degrees South latitude, 18.7 degrees East longitude Orientation: North-northeast at top Image Data: Landsat Bands 1, 2, 3 merged as grey Date Acquired: February 2000 (SRTM), June 13, 2000 (Landsat)

How trait anxiety, interpretation bias and memory affect acquired fear in children learning about new animals.

PubMed

Field, Zoë C; Field, Andy P

2013-06-01

Cognitive models of vulnerability to anxiety propose that information processing biases such as interpretation bias play a part in the etiology and maintenance of anxiety disorders. However, at present little is known about the role of memory in information processing accounts of child anxiety. The current study investigates the relationships between interpretation biases, memory and fear responses when learning about new stimuli. Children (aged 8-11 years) were presented with ambiguous information regarding a novel animal, and their fear, interpretation bias, and memory for the information was measured. The main findings were: (1) trait anxiety and interpretation bias significantly predicted acquired fear; (2) interpretation bias did not significantly mediate the relationship between trait anxiety and acquired fear; (3) interpretation bias appeared to be a more important predictor of acquired fear than trait anxiety per se; and (4) the relationship between interpretation bias and acquired fear was not mediated by the number of negative memories but was mediated by the number of positive and false-positive memories. The findings suggest that information processing models of child anxiety need to explain the role of positive memory in the formation of fear responses.

Internet Civil Defense: Feasibility Study

DTIC Science & Technology

2002-12-09

quell spread of false rumors that induce fear. Summary: Internet Civil Defense can help to manage fear in various ways. We can continuously poll...timely information to minimize rumors and accelerate recovery from disasters. ICD will create an “umbrella” framework to raise the overall...information to minimize rumors and accelerate recovery from disasters. Overall, ICD will collect and deliver actionable information to enhance public

The dimensionality of disclosure of HIV status amongst post-partum women in Cape Town, South Africa.

PubMed

Hunter-Adams, Jo; Zerbe, Allison; Philips, Tamsin; Rini, Zanele; Myer, Landon; Petro, Greg; Abrams, Elaine

2017-07-01

Disclosure of HIV status to sexual partners and others has been presented as positive health behaviour and is widely encouraged by antiretroviral treatment (ART) programmes, providers and policies. However, disclosure is also highly contextual and its positive effects are not universal. We explore the dimensions of disclosure amongst post-partum women who initiated ART during pregnancy in Cape Town, South Africa. Forty-seven semi-structured interviews with post-partum women were conducted as part of the Maternal Child Health-Antiretroviral Therapy (MCH-ART) study. Primary elements of disclosure were coded and interpreted according to dominant themes and subthemes. Disclosure was commonplace in the sample, ranging from widely disclosing status (rare); to disclosing to some family, friends and partners; to tacit disclosure, where participants took medication in front of others without explicitly discussing their status. Women described reasons for non-disclosure in terms of not being ready, fear of negative reactions (including violence and loss of financial support), and fear of their status being widely known. Self-reported adherence was uniformly high throughout the range of disclosure. Even those who made special efforts to avoid disclosure, such as attending clinics distant from their homes, reported good adherence. Those who disclosed experienced a range of responses to their disclosure, from support to shunning. Despite access to ART, stigma remained a persistent feature in descriptions of disclosure, particularly in relation to partner disclosure. Our findings suggest that disclosure is not always positive and adherence can be maintained within a wide range of disclosure behaviours. It is important that clinic settings allow women to retain control over their disclosure process.

Hydrogeologic framework and ground-water resources at Seymour Johnson Air Force Base, North Carolina

USGS Publications Warehouse

Cardinell, A.P.; Howe, S.S.

1997-01-01

A preliminary hydrogeologic framework of the Seymour Johnson Air Force Base was constructed from published data, available well data, and reports from Air Base files, City of Goldsboro and Wayne County records, and North Carolina Geological Survey files. Borehole geophysical logs were run in selected wells; and the surficial, Black Creek, and upper Cape Fear aquifers were mapped. Results indicate that the surficial aquifer appears to have the greatest lateral variability of clay units and aquifer material of the three aquifers. A surficial aquifer water-level surface map, constructed from selected monitoring wells screened exclusively in the surficial aquifer, indicates the general direction of ground-water movement in this mostly unconfined aquifer is toward the Neuse River and Stoney Creek. However, water-level gradient data from a few sites in the surficial aquifer did not reflect this trend, and there are insufficient hydrologic and hydrogeologic data to determine the cause of these few anamalous measurements. The Black Creek aquifer underlies the surficial aquifer and is believed to underlie most of Wayne County, including the Air Base where the aquifer and overlying confining unit are estimated from well log data to be as much as 100 feet thick. The Black Creek confining unit ranges in thickness from less than 8 feet to more than 20 feet. There are currently no accessible wells screened exclusively in the Black Creek aquifer from which to measure water levels. The upper Cape Fear aquifer and confining unit are generally found at depths greater than 80 feet below land surface at the Air Base, and are estimated to be as much as 70 feet thick. Hydrologic and hydrogeologic data are insufficient to determine localized surficial aquifer hydrogeology, ground-water movement at several sites, or hydraulic head differences between the three aquifers.

Mapping Relative Sea Level Influences of the Cape Fear Arch in southern North Carolina

NASA Astrophysics Data System (ADS)

Hawkes, A.; Kemp, A.; Capar, P.

2017-12-01

Long-term relative sea-level (RSL) records are a necessary benchmark by which to gauge present accelerated rates of sea-level rise, future sea-level predictions, and their implications to the coastal zone. The east coast of the United States functions as a significant region of latitudinal RSL variability due to the continuous recovery of land from the deglaciation of the Laurentide Ice Sheet since the Last Glacial Maximum. Differential glacial isostatic adjustment (GIA) along the coastline has caused higher rates of subsidence in areas around the former forbulge maxima near New Jersey and Delaware and lower rates to the north and south of this maxima. However, the coast between southern North Carolina and northern South Carolina is experiencing a slower rate of RSL rise then is seen in reconstructed GIA latitudinal trends along the U.S. east coast. It was thought that this could have been attributed to non-isostatic, long-term tectonic processes causing less GIA subsidence of the lithosphere within the region impacted by uplift from the Cape Fear Arch (CFA), an underlying crystalline basement high. A recent study suggests that RSL rise is slower around the CFA than areas to the north and south due to suggested CFA uplift rates of 0.24+0.15mm a-1. An absence of RSL records for 200km north of the CFA make mapping of its influence difficult. Additional RSL records to the north of the CFA allow for a better understanding of the asymmetrical distribution in the rate of RSL rise in this region. Because the distribution in the rate of RSLR between records is not linear it is important for these low-lying coastal communities to better understand their risk to future RSLR.

Layers of 'Cape Verde' in 'Victoria Crater' (False Color)

NASA Technical Reports Server (NTRS)

2006-01-01

This view of Victoria crater is looking north from 'Duck Bay' towards the dramatic promontory called 'Cape Verde.' The dramatic cliff of layered rocks is about 50 meters (about 165 feet) away from the rover and is about 6 meters (about 20 feet) tall. The taller promontory beyond that is about 100 meters (about 325 feet) away, and the vista beyond that extends away for more than 400 meters (about 1300 feet) into the distance. This is an enhanced false color rendering of images taken by the panoramic camera (Pancam) on NASA's Mars Exploration Rover Opportunity during the rover's 952nd sol, or Martian day, (Sept. 28, 2006) using the camera's 750-nanometer, 530-nanometer and 430-nanometer filters.

"Cape Town, South Africa taken from Atlantis during STS-106"

NASA Image and Video Library

2000-09-19

STS106-713-057 (19 September 2000) --- One of the STS-106 crew members on board the Space Shuttle Atlantis used a handheld 70mm camera to photograph this image of Cape Town and the Karroo Ranges in South Africa. Cape Town occupies the north end of the Cape of Good Hope peninsula and extends to the shore of False Bay. The city is home to about 2.7 million people. Tourism and viticulture contribute importantly to the local economy, and the city is a service center for government and industry -- particularly mining. The great folded mountain ranges of South Africa were formed during the assembly of the ancient super continent of Gondwana. Broad N-trending folds of the Cedarburg range, South Africa formed first, according to geologists, about 230 million years ago, and the W-trending Karroo ranges formed a little later.

Use of crystal methamphetamine among male adolescents in Cape Town, South Africa: Caregivers' experiences.

PubMed

Asante, Kwaku Oppong; Lentoor, Antonio G

2017-03-27

Against the background that crystal methamphetamine (colloquially known as "tik") is extensively used by the emerging working class Coloured youth in Cape Town, South Africa, this exploratory qualitative study was conducted to explore the experience of mothers whose children use methamphetamine. The researchers conducted one-to-one semi-structured in-depth interviews with sixteen (16) purposively selected caregivers (mothers) whose sons use methamphetamine. Interviews were recorded and simultaneously translated and transcribed. Thematic analysis was used to identify themes related to the experiences of caregivers of youth with methamphetamine problems. Findings showed that youth misbehaviour provided a context that led to feelings of shame and embarrassment. Participants also experienced personal challenges which included emotional problems, fear and self-blame. Participants also expressed family disruptions and financial drain as adverse experiences as a results of their sons' misbehaviour. The study results highlight the psychosocial challenges for caregivers of children who use methamphetamine. These findings underscore the need for effort to be directed at the development of formal support interventions for mothers of youth who are troubled with addiction.

HIV/AIDS-related stigma in South African alcohol-serving venues and its potential impact on HIV disclosure, testing, and treatment-seeking behaviours

PubMed Central

Velloza, Jennifer; Watt, Melissa H.; Choi, Karmel W.; Abler, Laurie; Kalichman, Seth C.; Skinner, Donald; Pieterse, Desiree; Sikkema, Kathleen J.

2015-01-01

Alcohol-serving venues in South Africa are sites for high-risk behaviours that may lead to HIV transmission. Prevention and treatment interventions are sorely needed in these settings, but HIV-related stigma may limit their effectiveness. This study explored expressions of stigma among alcohol-serving venue patrons in Cape Town and examined the potential impact of stigma on HIV disclosure, testing, and treatment-seeking behaviours. A total of 92 in-depth interviews with male and female, Black and Coloured patrons were conducted. Transcripts were analysed via memo-writing and diagramming techniques. Many participants mentioned knowing other patrons living with HIV/AIDS (PLWH), and this visibility of HIV impacted expressions of HIV-related stigma. Participants discussed four forms of HIV-related stigma in the venues: fearing PLWH, fearing HIV acquisition, blaming others for spreading HIV, and isolating PLWH. HIV visibility and expressions of HIV-related stigma, particularly fear of isolation, influenced participants’ willingness to disclose their status. HIV-related stigma in the venues also appeared to indirectly influence testing and treatment-seeking behaviour outside the venue. Results suggest that efforts to change norms and reduce expressions of HIV-related stigma in alcohol-serving venues are necessary to successfully deliver tailored HIV prevention interventions and increase uptake of HIV testing and care in this important social setting. PMID:25630531

50 CFR Table 2 to Part 226 - Major Stellar Sea Lion Haulout Sites in Alaska

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Major Stellar Sea Lion Haulout Sites in.... 226, Table 2 Table 2 to Part 226—Major Stellar Sea Lion Haulout Sites in Alaska Major Steller sea lion... 19.5W Tigalda I. 1 54 08.5N 164 58.5W Umnak I./Cape Aslik 1 53 25.0N 168 24.5W Bering Sea: Cape...

50 CFR Table 2 to Part 226 - Major Stellar Sea Lion Haulout Sites in Alaska

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Major Stellar Sea Lion Haulout Sites in.... 226, Table 2 Table 2 to Part 226—Major Stellar Sea Lion Haulout Sites in Alaska Major Steller sea lion... 19.5W Tigalda I. 1 54 08.5N 164 58.5W Umnak I./Cape Aslik 1 53 25.0N 168 24.5W Bering Sea: Cape...

Exploring the Health Needs of Aging LGBT Adults in the Cape Fear Region of North Carolina.

PubMed

Rowan, Noell L; Beyer, Kelsey

2017-01-01

This study explored issues of culturally sensitive healthcare practice and needs among lesbian, gay, bisexual and transgender aging adults in coastal North Carolina. Survey data results indicated the largest problem was a history of verbally harassment and need for culturally sensitive healthcare. In conclusion, culturally sensitive interventions are needed to address the health disparities and unique needs of LGBT aging adults. Cultural sensitivity training for service providers is suggested as a vital step in addressing health disparities of aging LGBT adults. Implications for research include further exploration of health related needs of these often hidden and underserved population groups.

False context fear memory in rats.

PubMed

Bae, Sarah E; Holmes, Nathan M; Westbrook, R Frederick

2015-10-01

Four experiments used rats to study false context fear memories. In Experiment 1, rats were pre-exposed to a distinctive chamber (context A) or to a control environment (context C), shocked after a delay in a second chamber (context B) and tested either in B or A. Rats pre-exposed to A froze just as much as control rats in B but more than control rats in A. In Experiment 2, rats were pre-exposed to A or C, subjected to an immediate shock in B and tested in B or A. Rats pre-exposed to A froze when tested in A but did not freeze when tested in B and control rats did not freeze in either A or B. The false fear memory to the pre-exposed A was contingent on its similarity with the shocked B. In Experiment 3, rats pre-exposed to A and subjected to immediate shock in B froze when tested in A but did not freeze when tested in C and rats pre-exposed to C did not freeze when tested either in A or C. In Experiment 4, rats pre-exposed to A and subjected to immediate shock in B froze more when tested in A than rats whose pre-exposure to A began with an immediate shock. The results were discussed in terms of a dual systems explanation of context fear conditioning: a hippocampal-dependent process that forms a unitary representation of context and an amygdala-based process which associates this representation with shock. © 2015 Bae et al.; Published by Cold Spring Harbor Laboratory Press.

Emotion and false memory: How goal-irrelevance can be relevant for what people remember.

PubMed

Van Damme, Ilse; Kaplan, Robin L; Levine, Linda J; Loftus, Elizabeth F

2017-02-01

Elaborating on misleading information concerning emotional events can lead people to form false memories. The present experiment compared participants' susceptibility to false memories when they elaborated on information associated with positive versus negative emotion and pregoal versus postgoal emotion. Pregoal emotion reflects appraisals that goal attainment or failure is anticipated but has not yet occurred (e.g., hope and fear). Postgoal emotion reflects appraisals that goal attainment or failure has already occurred (e.g., happiness and devastation). Participants watched a slideshow depicting an interaction between a couple and were asked to empathise with the protagonist's feelings of hope (positive pregoal), happiness (positive postgoal), fear (negative pregoal), or devastation (negative postgoal); in control conditions, no emotion was mentioned. Participants were then asked to reflect on details of the interaction that had occurred (true) or had not occurred (false), and that were relevant or irrelevant to the protagonist's goal. Irrespective of emotional valence, participants in the pregoal conditions were more susceptible to false memories concerning goal-irrelevant details than were participants in the other conditions. These findings support the view that pregoal emotions narrow attention to information relevant to goal pursuit, increasing susceptibility to false memories for irrelevant information.

Expectancy, False Galvanic Skin Response Feedback, and Systematic Desensitization in the Modification of Phobic Behavior

ERIC Educational Resources Information Center

Lick, John

1975-01-01

This study compared systematic desensitization and two pseudotherapy manipulations with and without false galvanic skin response feedback after every session suggesting improvement in the modification of intense snake and spider fear. The results indicated no consistent differences between the three treatment groups. (Author)

Evidence for extensive methane venting on the southeastern U.S. Atlantic margin

USGS Publications Warehouse

Brothers, L.L.; Van Dover, C.L.; German, C.R.; Kaiser, C.L.; Yoerger, D.R.; Ruppel, C.D.; Lobecker, E.; Skarke, A.D.; Wagner, J.K.S.

2013-01-01

We present the first evidence for widespread seabed methane venting along the southeastern United States Atlantic margin beyond the well-known Blake Ridge diapir seep. Recent ship- and autonomous underwater vehicle (AUV)–collected data resolve multiple water-column anomalies (>1000 m height) and extensive new chemosynthetic seep communities at the Blake Ridge and Cape Fear diapirs. These results indicate that multiple, highly localized fluid conduits punctuate the areally extensive Blake Ridge gas hydrate province, and enable the delivery of significant amounts of methane to the water column. Thus, there appears to be an abundance of seabed fluid flux not previously ascribed to the Atlantic margin of the United States.

Cape Verde in False Color

NASA Technical Reports Server (NTRS)

2007-01-01

A promontory nicknamed 'Cape Verde' can be seen jutting out from the walls of Victoria Crater in this false-color picture taken by the panoramic camera on NASA's Mars Exploration Rover Opportunity. The rover took this picture on martian day, or sol, 1329 (Oct. 20, 2007), more than a month after it began descending down the crater walls -- and just 9 sols shy of its second Martian birthday on sol 1338 (Oct. 29, 2007). Opportunity landed on the Red Planet on Jan. 25, 2004. That's nearly four years ago on Earth, but only two on Mars because Mars takes longer to travel around the sun than Earth. One Martian year equals 687 Earth days.

This view was taken using three panoramic-camera filters, admitting light with wavelengths centered at 750 nanometers (near infrared), 530 nanometers (green) and 430 nanometers (violet).

False Accusations: A Growing Fear in the Classroom

ERIC Educational Resources Information Center

Bradley, Jon

2011-01-01

Male role models are becoming increasingly scarce in Canadian classrooms, and the demographics indicate that the current low numbers will continue to decline. New teachers are quite prepared to take up the pedagogical issues raised by changing standards and a changing demographic; however, the spectre of violence and false accusations adds a level…

Earth observations during STS-89 mission

NASA Image and Video Library

1998-01-31

STS089-706-068 (22-31 Jan. 1998) --- This nadir view of the southern Cape District of South Africa was photographed with a 70mm handheld camera from the Earth-orbiting space shuttle Endeavour. Prominent landmarks are the Cape of Good Hope, False Bay and Cape Town. Cape Town is the gray area at the base of the peninsula that forms the Cape of Good Hope. East and north of Cape Town the dark mountain ranges are the Cape Fold Belt. Northerly structures of the region formed approximately 580 million years ago when east Antarctica, Africa and parts of South America combined. According to NASA scientists those continents separated and then recombined about 230 million years ago; in the later event, the northerly structures were again active and the west-trending folds of the Great and Little Karroo ranges formed. The westerly structures of the Karroo formed somewhat later; the northerly structures were re-folded at that time. The great continental mass, Gondwana, remained together until around 175 million years ago, when it rifted apart leaving the coastline essentially as it is seen today. Photos such as this are useful to geologists working in these areas as they provide, quite literally, the big picture in complex regions. Other items of interest are the internal waves noted offshore, several trains can be seen east, north and south of Cape Town. In the mountains to the north (upper left corner) a large brush fire is seen from the smoke plume. The giant gold and diamond mines are located northeast and east of this photo. The gold province is primarily located around Johannesburg (450 miles northeast) and the diamond mines are approximately 300 miles northeast around Kimberley. Photo credit: NASA

Movement and dispersion of soluble pollutants in the Northeast Cape Fear Estuary, North Carolina

USGS Publications Warehouse

Hubbard, E.F.; Stamper, William G.

1972-01-01

This report presents the results of a fluorescent-dye-tracing study to determine the concentrations of a pollutant that would be present in the Northeast Cape Fear Estuary at various rates of continuous waste injection and freshwater inflow. Rhodamine WT dye was introduced into the estuary at a constant rate over a 24.8-hour period (two tidal cycles) at a point 6.4 miles upstream from the mouth in Wilmington, N.C., and concentrations were monitored at several selected sections in the tide-affected part of the river for 17 days. The range between high and low tide in this reach of the estuary averages at-rut 3.5 feet, and there is usually strong flow in both directions. Results of the dye study indicate that if a pollutant were injected at a rate of 100 pounds per day under the conditions of relatively low inflow existing' at the time, concentrations would ultimately build up to 20 micrograms of dye per liter of water 1,000 feet downstream. The flushing time during the study is estimated to be 17 days. These results are extrapolated to include periods of lower or higher inflow. For example, at average intervals of 10 years, it is estimated that inflow is so low that 100 days are required for a pollutant to travel the 6.4 miles from the point of waste release to the mouth of the river. Under these conditions it is expected that 1,000 feet downstream from the point of waste discharge, daily maximum concentrations will average about 130 micrograms per liter for each 100 pounds of pollutant injected per day. Results of a continuous discharge measurement of flow made by current meter during a complete tidal cycle are presented as a part of this report. Data from this measurement and other evidence indicate that net upstream flow in the estuary is possible over a period of several days.

Changes of oxidase and hydrolase activities in pecan leaves elicited by black pecan aphid (Hemiptera: Aphididae) feeding.

PubMed

Chen, Yigen; Ni, Xinzhi; Cottrell, Ted E; Wood, Bruce W; Buntin, G David

2009-06-01

The black pecan aphid, Melanocallis caryaefoliae (Davis) (Hemiptera: Aphididae), is a foliar feeder of pecan, Carya illinoinensis (Wangenh.) K. Koch (Juglandaceae). The pest causes chlorosis of leaflet lamina, physiological damage to foliage and trees, and commonly limits the profitability of commercial pecan orchard enterprises. However, key aspects of this host-pest interaction are poorly understood. We report here the effects of M. caryaefoliae feeding on the foliar activity of oxidative (i.e., catalase, lipoxygenase [LOX]-1 and 3, and peroxidase) and hydrolytic (i.e., esterase) enzymes in relation to the degree of aphid resistance among pecan varieties. The 2-yr study showed that M. caryaefoliae-infested foliage exhibited elevated peroxidase activity only in susceptible ('Desirable', 'Sumner', and 'Schley'), but not in resistant ('Cape Fear', 'Gloria Grande', and 'Money Maker') genotypes. Susceptible genotypes also exhibited more severe leaf chlorosis in response to M. caryaefoliae feeding than the resistant genotypes; however, the aphid feeding did not influence catalase or esterase activity in all varieties, except the increase of esterase activity in Desirable and Gloria Grande. Melanocallis caryaefoliae feeding also influences activity of two lipoxygenase isozymes, with LOX3 being more frequently induced than LOX1. Foliar LOX3 activity was more frequently induced by M. caryaefoliae feeding in the moderately resistant 'Oconee' and highly resistant Money Maker and Cape Fear than in the susceptible genotypes. Therefore, the elevation of peroxidase is likely to be associated with aphid susceptibility and contributed to the severe leaf chlorosis, whereas the increase of LOX3 activity might be associated with aphid resistance in pecan. These findings contribute to our understanding of the etiology of M. caryaefoliae-elicited leaf chlorosis on pecan foliage. Such information may also be used to develop enzyme markers for identifying black pecan aphid resistance and/or susceptibility in pecan germplasm.

Effect of low-head lock and dam structures on migration and spawning of American shad and striped bass in the Cape Fear River, North Carolina

USGS Publications Warehouse

Smith, Joseph A.; Hightower, Joseph E.

2012-01-01

Anadromous fish populations within the Cape Fear River, North Carolina, have declined substantially since the late 1800s. Three low-head lock-and-dam (LD) structures on the river (LD-1–3) contributed to this decline by limiting access to upstream spawning habitat. We used egg sampling and sonic telemetry to examine the effects of the LD structures on migration and spawning activity of American shad Alosa sapidissima and striped bassMorone saxatilis. Egg distribution and stage of development suggested that most of the American shad spawning took place downstream from the lowermost structure, LD-1. The predicted mean density of stage-1 American shad eggs at a water temperature of 21°C was 895 eggs/1,000 m3 (95% credible interval [CI] = 800–994) below LD-1; 147 eggs/1,000 m3 (95% CI = 103–197) below LD-2; and 32 eggs/1,000 m3 (95% CI = 17–49) below the uppermost structure, LD-3. The probability of capturing a stage-1 American shad egg was strongly dependent on water temperature and hour of egg collection. Transmitter detections for 20 sonic-tagged American shad and 20 striped bass in 2008 showed that for both species, the majority of fish moved upstream of LD-1; 35% of American shad and 25% of striped bass migrated upstream of LD-3. Based on passage rates at the three LD structures, American shad would be expected to be most abundant downstream of LD-1 and upstream of LD-3. For striped bass, the river section between LD-2 and LD-3 had the highest egg collections and highest predicted proportion of the run. In combination, these results demonstrate that the locking program provides some access to historical spawning habitat, although further improvements in fish passage could benefit both species.

Quality of surface-water supplies in the Triangle Area of North Carolina, water years 2012–13

USGS Publications Warehouse

Pfeifle, C.A.; Cain, J.L.; Rasmussen, R.B.

2016-09-07

Surface-water supplies are important sources of drinking water for residents in the Triangle area of North Carolina, which is located within the upper Cape Fear and Neuse River Basins. Since 1988, the U.S. Geological Survey and a consortium of local governments have tracked water-quality conditions and trends in several of the area’s water-supply lakes and streams. This report summarizes data collected through this cooperative effort, known as the Triangle Area Water Supply Monitoring Project, during October 2011 through September 2012 (water year 2012) and October 2012 through September 2013 (water year 2013). Major findings for this period include:Annual precipitation was approximately 2 percent above the long-term mean (average) annual precipitation in 2012 and approximately 3 percent below the long-term mean in 2013.In water year 2012, streamflow was generally below the long-term mean during most of the period for the 10 project streamflow gaging stations. Streamflow was near or above the long-term mean at the same streamflow gaging stations during the 2013 water year.More than 7,000 individual measurements of water quality were made at a total of 17 sites—6 in the Neuse River Basin and 11 in the Cape Fear River Basin. Forty-three water-quality properties or constituents were measured; State water-quality standards exist for 23 of these.All observations met State water-quality standards for pH, temperature, hardness, chloride, fluoride, sulfate, nitrate, arsenic, cadmium, chromium, lead, nickel, and selenium.North Carolina water-quality standards were exceeded one or more times for dissolved oxygen, dissolved-oxygen percent saturation, turbidity, chlorophyll a, copper, iron, manganese, mercury, silver, and zinc. Exceedances occurred at all 17 sites.Stream samples collected during storm events contained elevated concentrations of 19 water-quality constituents relative to non-storm events.

Hydrogeologic Framework of Onslow County, North Carolina, 2008

USGS Publications Warehouse

Fine, Jason M.

2008-01-01

The unconsolidated sediments that underlie the Onslow County area are composed of interlayered permeable and impermeable beds, which overlie the crystalline basement rocks. The aquifers, composed mostly of sand and limestone, are separated by confining units composed mostly of clay and silt. The aquifers from top to bottom are the surficial, Castle Hayne, Beaufort, Peedee, Black Creek, and Upper and Lower Cape Fear aquifers. For this study, the Castle Hayne aquifer is informally divided into the upper and lower Castle Hayne aquifers. The eight aquifers and seven confining units of the Tertiary and Cretaceous strata beneath Onslow County are presented in seven hydrogeologic sections. The hydrogeologic framework was refined from existing interpretations by using geophysical logs, driller's logs, and other available data from 123 wells and boreholes.

Water-quality data for selected North Carolina streams and reservoirs in the Triangle Area Water Supply Monitoring Project, 1988-92

USGS Publications Warehouse

Garrett, Ronald G.; Taylor, John E.; Middleton, Terry L.

1994-01-01

The Triangle Area Water Supply Monitoring Project was developed to assess regional water-quality characteristics in drinking-water supplies and to provide a basis for determining trends in water quality for the Research Triangle area, which is one of the fastest growing areas in North Carolina. The study area is in the upper Neuse River Basin and the upper Cape Fear River Basin in the north-central Piedmont Province of the State. Hydrologic data were collected at 21 reservoir sites and 30 stream sites from October 1988 through September 1992 to define water-quality characteristics. The data collected at these sites include streamflow data and approximately 275 physical properties and chemical characteristics of surface water.

"If I feel disgusted, I must be getting ill": emotional reasoning in the context of contamination fear.

PubMed

Verwoerd, Johan; de Jong, Peter J; Wessel, Ineke; van Hout, Wiljo J P J

2013-03-01

Patients suffering from anxiety disorders have been shown to infer danger on the basis of their anxiety responses "if I feel anxious, there must be danger." This tendency logically hampers the identification of false alarms and may thus act in a way to confirm the a priori threat value of the feared stimuli/situations. Since disgust is assumed to play a critical role in the persistence of contamination fears in OCD, the question rises whether individuals suffering from fear of contamination perhaps similarly infer danger on the basis of their disgust response: "If I feel disgusted, it must be contagious." Therefore, this study tested whether indeed disgust-based reasoning might be involved in fear of contamination. On the basis of the contamination fear subscale of the Padua Inventory (PI), we selected a group of participants scoring higher than the established clinical range (n=31, PI>13) and a group of participants low (n=27, PI<5) in contamination fear. Each participant was presented with a series of 2 times 4 types of scripts that systematically varied in the absence/presence of objective threat of contamination and the absence/presence of the actor's disgust response. Following each script, participants rated their perceived threat of contamination/illness. In line with the hypothesis that disgust-based reasoning might be involved in fear of contamination, specifically high contamination fearful individuals inferred risk of becoming ill on the basis of experienced disgust (in addition to objective threat), as was evidenced by a significant Group (high vs. low)×Threat (yes vs. no)×Disgust response (yes vs. no) interaction. This finding might not only help to explain the persistence of contamination fears, but also provides some fresh clues to improve currently available treatment options. Copyright © 2012 Elsevier Ltd. All rights reserved.

Maximum depositional ages and evolving provenance of Franciscan metagraywackes, NW California: LA-ICPMS zircon U-Pb data

NASA Astrophysics Data System (ADS)

Ernst, W. G.; Dumitru, T. A.; Tsujimori, T.; McLaughlin, R. J.; Makishima, A.; Nakamura, E.

2012-12-01

In the Cape Mendocino-Garberville-Covelo area, the Franciscan Complex comprises an imbricate stack of east-rooting allochthons. Five structurally higher to lower thrust sheets crop out from east to west: Eastern Belt outliers; Central Belt mélange; Coastal Belt Yager terrane; Coastal Belt Coastal terrane; and Coastal Belt King Range/False Cape terranes. We analyzed detrital zircons from 11 rocks: 2 Eastern Belt; 5 Central Belt; 4 King Range/False Cape terrane. Combined with earlier analyses of 3 Yager terrane and 3 Coastal terrane zircon suites (Dumitru et al., in review), 17 rocks were investigated. Maximum ages of sedimentation and inferred ultimate sources of these units as follows. Eastern Belt (Yolla Bolly): 98-120 Ma Sierran batholith, 140- 230 Ma Andean arc, minor 1300-1400 Ma Mazatzal granites, minor 1800 Ma Yavapai basement, trace >2.5 Ga Archean craton. Central Belt: minor 62-80 Ma Idaho batholith, 85-200 Ma Sierran batholith-Andean arc, 1300-1400 Ma Mazatzal granites, minor 1600-1750 Ma Mazatzal-Yavapai basement. Yager terrane: 50-75 Ma Idaho batholith, 85-120 Ma Sierran batholith, minor 160-200 Ma Andean arc. Coastal terrane: 30-50 Ma, Cascade + Challis volcanics, 55-80 Ma Idaho batholith, 100 Ma Sierran batholith, 1300-1400 Ma, Mazatzal granites. King Range/False Cape terrane: 22-50 Ma Cascade + Challis Idaho batholith, 100-180 Ma Sierran batholith-Andean arc, minor 1400 Ma Mazatzal-Yavapai granites. Depositional ages of Franciscan imbricate thrust sheets young westward from the mid Cretaceous Eastern Belt through the end-of-Cretaceous Central Belt, to the Paleogene Coastal Belt. Over time, the Franciscan received greater proportions of younger clastics derived from more northerly sources. Although mostly arc-derived, some recycled 1400 and 1700-1800 Ma ± 2.5 Ga arc zircons probably were supplied to the Franciscan Complex by erosion and westward transport of detrital grains from Lower Paleozoic miogeoclinal strata covering the cratonal edge. Except for metagraywackes of the Early Cretaceous Skaggs Spring Schist and Picket Peak terrane, Grenville and Appalachian igneous zircons are conspicuously missing from mid-Cretaceous and younger Franciscan rocks, supporting northwestward offset of the trench deposits relative to SW North America.

The role of fear in diagnosing cancer in time.

PubMed

Machácek, J

1996-01-01

The causes of the relatively frequent late discovery of the breast cancer (40-60%) in Czech republic are numerous. One of them is the attitude of the patient herself to the disease. Fear and anxiety play are important role in seeing her doctor too late. Beliefs feelings and attitudes to treatment have been formed in potential patients mostly by negative experience and information. It is necessary to impress to the female population the idea that breast cancer can be curable and that the degree of successful treatment depends on early diagnosis and that fear and anxiety delaying the therapy are dangerous. The sources of fear are as follows: false image of incurable disease an idea of subsequent loss of an organs--the symbols of womanhood and sex-appeal physical and psychical degradation subsequent fears of losing a partner loss of social prestige and position at work considerable change in hitherto lifestyle. Own knowledge that these negative ideas are not quite true must be accepted not only by these who have been treated but first of all by those who could find themselves in such a difficult situation. Many other potential sources of fear and worries concern health care. Apart from the lack of interest reluctance and rudeness of hospital staff it is a chronic shortcoming of positive information and intensive health education. In authors group of 120 patients has been proved that mental feelings, fear and anxiety significantly influence the timeliness of diagnosing an illness and its whole course. It is the physicians foremost task to look for any possible ways of overcoming the sources of fear and anxiety and thus to help women to see a doctor as soon as possible. It would be a significant contribution to decreasing the number of advanced stages of breast cancer.

High Martian Viewpoint for 11-Year-Old Rover False-Color Landscape

NASA Image and Video Library

2015-01-22

NASA Mars Exploration Rover Opportunity obtained this view from the top of the Cape Tribulation segment of the rim of Endeavour Crater. The rover reached this point three weeks before the 11th anniversary of its January 2004 landing on Mars.

The neural representation of typical and atypical experiences of negative images: comparing fear, disgust and morbid fascination

PubMed Central

Lindquist, Kristen A.; Adebayo, Morenikeji; Barrett, Lisa Feldman

2016-01-01

Negative stimuli do not only evoke fear or disgust, but can also evoke a state of ‘morbid fascination’ which is an urge to approach and explore a negative stimulus. In the present neuroimaging study, we applied an innovative method to investigate the neural systems involved in typical and atypical conceptualizations of negative images. Participants received false feedback labeling their mental experience as fear, disgust or morbid fascination. This manipulation was successful; participants judged the false feedback correct for 70% of the trials on average. The neuroimaging results demonstrated differential activity within regions in the ‘neural reference space for discrete emotion’ depending on the type of feedback. We found robust differences in the ventrolateral prefrontal cortex, the dorsomedial prefrontal cortex and the lateral orbitofrontal cortex comparing morbid fascination to control feedback. More subtle differences in the dorsomedial prefrontal cortex and the lateral orbitofrontal cortex were also found between morbid fascination feedback and the other emotion feedback conditions. This study is the first to forward evidence about the neural representation of the experimentally unexplored state of morbid fascination. In line with a constructionist framework, our findings suggest that neural resources associated with the process of conceptualization contribute to the neural representation of this state. PMID:26180088

Gene networks associated with conditional fear in mice identified using a systems genetics approach

PubMed Central

2011-01-01

Background Our understanding of the genetic basis of learning and memory remains shrouded in mystery. To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution. Results A total of 27 behavioral quantitative trait loci were mapped with a false discovery rate of 5%. By integrating fear phenotypes, transcript profiling data from hippocampus and striatum and also genotype information, two gene co-expression networks correlated with context-dependent immobility were identified. We prioritized the key markers and genes in these pathways using intramodular connectivity measures and structural equation modeling. Highly connected genes in the context fear modules included Psmd6, Ube2a and Usp33, suggesting an important role for ubiquitination in learning and memory. In addition, we surveyed the architecture of brain transcript regulation and demonstrated preservation of gene co-expression modules in hippocampus and striatum, while also highlighting important differences. Rps15a, Kif3a, Stard7, 6330503K22RIK, and Plvap were among the individual genes whose transcript abundance were strongly associated with fear phenotypes. Conclusion Application of our multi-faceted mapping strategy permits an increasingly detailed characterization of the genetic networks underlying behavior. PMID:21410935

Locating Shallow Groundwater Discharge to Streams Near Concentrated Animal Feeding Operations Using Aerial Infrared Thermography: A Novel Potential Pollution Detection Method

NASA Astrophysics Data System (ADS)

Mapes, K. L.; Pricope, N. G.

2017-12-01

The Cape Fear River Basin (CFRB) has some of the highest densities of concentrated animal feeding operations (CAFO) in the United States (factoryfarmmap.org) and was recently named one of the country's most endangered rivers (americanrivers.org). There is high potential for CAFO land use to degrade stream water quality by introducing pollutants, primarily nitrates and fecal coliform, into sub-surface and surface waters. The regionally high water table in the Lower CFRB increases the risk of water quality degradation due to increased connectivity of ground- and surface water. The Lower CFRB is periodically subjected to frequent or intense hurricanes, which have been shown to exacerbate water quality issues associated with CAFOs. Additionally, the growing population in this region is placing more pressure on an already taxed water source and will continue to rely on the Cape Fear River for drinking water and wastewater discharge. While there are documented occurrences of groundwater contamination from CAFOs, we still have little understanding on how and where pollution may be entering streams by shallow sub-surface discharge. Shallow groundwater discharge to streams is becoming easier to detect using thermal infrared imaging cameras onboard unmanned aerial systems. The temperature differences between groundwater and stream water are easily distinguished in the resulting images. While this technology cannot directly measure water quality, it can locate areas of shallow groundwater discharge that can later be tested for pollutants using conventional methods. We will utilize a thermal infrared camera onboard a SenseFly eBee Plus to determine the feasibility of using this technology on a larger scale within the Lower CFRB as an inexpensive means of identifying sites of potential pollution input. Aerial surveys will be conducted in two sub-watersheds: one containing swine CAFO and a control that lacks swine CAFO. Information from this study can be integrated into subsequent water quality models within geographic information systems. Understanding how and where CAFO-related pollution is entering streams will also greatly assist scientists, conservationists, and farmers with designing experiments and implementing best management practices that produce measurable improvements to water quality.

Women's experiences seeking informal sector abortion services in Cape Town, South Africa: a descriptive study.

PubMed

Gerdts, Caitlin; Raifman, Sarah; Daskilewicz, Kristen; Momberg, Mariette; Roberts, Sarah; Harries, Jane

2017-10-02

In settings where abortion is legally restricted, or permitted but not widely accessible, women face significant barriers to abortion access, sometimes leading them to seek services outside legal facilities. The advent of medication abortion has further increased the prevalence of informal sector abortion. This study investigates the reasons for attempting self-induction, methods used, complications, and sources of information about informal sector abortion, and tests a specific recruitment method which could lead to improved estimates of informal sector abortion prevalence among an at-risk population. We recruited women who have sought informal sector abortion services in Cape Town, South Africa using respondent driven sampling (RDS). An initial seed recruiter was responsible for initiating recruitment using a structured coupon system. Participants completed face-to-face questionnaires, which included information about demographics, informal sector abortion seeking, and safe abortion access needs. We enrolled 42 women, nearly one-third of whom reported they were sex workers. Thirty-four women (81%) reported having had one informal sector abortion within the past 5 years, 14% reported having had two, and 5% reported having had three. These women consumed home remedies, herbal mixtures from traditional healers, or tablets from an unregistered provider. Twelve sought additional care for potential warning signs of complications. Privacy and fear of mistreatment at public sector facilities were among the main reported reasons for attempting informal sector abortion. Most women (67%) cited other community members as their source of information about informal sector abortion; posted signs and fliers in public spaces also served as an important source of information. Women are attempting informal sector abortion because they seek privacy and fear mistreatment and stigma in health facilities. Some were unaware how or where to seek formal sector services, or believed the cost was too high. Many informal methods are ineffective and unsafe, leading to potential warning signs of complications and continued pregnancy. Sex workers may be at particular risk of unsafe abortion. Based on these results, it is essential that future studies sample women outside of the formal health sector. The use of innovative sampling methods would greatly improve our knowledge about informal sector abortion in South Africa.

Quaternary geophysical framework of the northeastern North Carolina coastal system

USGS Publications Warehouse

Thieler, E.R.; Foster, D.S.; Mallinson, D.M.; Himmelstoss, E.A.; McNinch, J.E.; List, J.H.; Hammar-Klose, E.S.

2013-01-01

The northeastern North Carolina coastal system, from False Cape, Virginia, to Cape Lookout, North Carolina, has been studied by a cooperative research program that mapped the Quaternary geologic framework of the estuaries, barrier islands, and inner continental shelf. This information provides a basis to understand the linkage between geologic framework, physical processes, and coastal evolution at time scales from storm events to millennia. The study area attracts significant tourism to its parks and beaches, contains a number of coastal communities, and supports a local fishing industry, all of which are impacted by coastal change. Knowledge derived from this research program can be used to mitigate hazards and facilitate effective management of this dynamic coastal system.

South Africa as seen from STS-63 Discovery

NASA Technical Reports Server (NTRS)

1995-01-01

The southwest coast of southern Africa from St. Helena Bay (large bay at center), to Table Bay at Cape Town (bottom, with Robben Island near entrance). The pier at the naval base and fishing port of Saldhanaha Bay can be seen in the small bay (center). False Bay is cut off by the bottom edge of the frame. What NASA scientists think to be a phytoplankton bloom appears offshore in the cold upwelled water off the Atlantic coast. Farmland, especially that used for wine growing, is found near the coast occupying the Mediterranian-like climate of the Southwest Cape Province; but inland of the mountains of the Karroo Desert is home to sheep farmers and little agriculture.

Influence of holding temperature and irradiation on field performance of mass-reared Thaumatotibia leucotreta (Lepidoptera: Tortricidae)

USDA-ARS?s Scientific Manuscript database

The Sterile Insect Technique (SIT) as an integral component to the area-wide integrated management of the false codling moth, Thaumatotibia leucotreta (Meyrick) (Lepidoptera: Tortricidae), was successfully implemented in the Western Cape region of South Africa and subsequently expanded to citrus are...

The Back Belief Questionnaire is efficient to assess false beliefs and related fear in low back pain populations: A transcultural adaptation and validation study.

PubMed

Dupeyron, Arnaud; Lanhers, Charlotte; Bastide, Sophie; Alonso, Sandrine; Toulotte, Matthias; Jourdan, Claire; Coudeyre, Emmanuel

2017-01-01

According to the fear avoidance model, beliefs and thoughts can modify the outcome of patient with low back pain. The Back Belief Questionnaire (BBQ)-a 14 items scale-assesses these consequences of low back pain. To test the psychometric properties of the French version of the BBQ. The BBQ was translated using the forward-backward translation process. Throughout three repeated evaluation time points (D1, D7 and D30), various aspects of validity were analysed: acceptability, quality of items, unidimentionality, internal consistency, temporal stability (between D1 and D7), responsiveness (between D7 and D30), and construct validity comparing it to other validated scales. One hundred and thirty-one patients were enrolled and 128 were analyzed. The acceptability and the quality of the items were excellent. The scale was unidimensional and reliable (internal consistency: Cronbach's α = 0.8). The responsiveness was moderate but in line with other scores. The BBQ was, as expected, convergent with day-to-day activities and fear avoidance (FABQ and Tampa), disability (Quebec and Dallas scores), or anxiety and depression (HAD); and not correlated with pain. Best correlations were found with Tampa and FABQ. The temporal stability (test-retest reliability) was poor. However, similar changes were observed in near conceptual score (FABQ), which confirmed that clinical status may have not been stable and suggesting sensitivity to early changes for BBQ. The BBQ showed good psychometric properties to assess false beliefs and related fear in French or English LBP populations and can be used either for evaluation in international trials or as a part of self-care training.

Mid-range sidescan-sonar images covering parts of proposed tracts for OCS lease sale 56 and contiguous areas, Manteo, Cape Fear, and adjacent quadrangles off North Carolina

USGS Publications Warehouse

Popenoe, Peter; Cashman, K.V.; Chayes, Dale; Ryan, William B. F.

1981-01-01

The U.S. Geological Survey (USGS), in cooperation with the U.S. Bureau of Land Management (BLM) and the Lamont-Doherty Geological Observatory (LDGO), collected 335 km of mid-range sidescan-sonar data in some of the tracts proposed for inclusion in Federal OCS (Outer Continental Shelf) Oil and Gas Lease Sale 56 and in some contiguous areas (R.V. GYRE, September 18-25, 1980 [GYRE 80-9, leg 1]). The data were collected by use of the Sea Mark I mid-range sidescan-sonar system designed by International Submarine Technology, Ltd. (IST). This system surveys a swath having a width of approximately 2-1/2 km on each side of the deep-towed fish. Transducers were towed about 300 m above the bottom on a neutrally bouyant vehicle at a speed of 1-1/2 to 2 knots. Transducers were pulsed at 4-second intervals at a frequency of 27 kHz on one side and 30 kHz on the other. Data recorded on seven EPC recorders aboard ship included slant-range corrected port channel, starboard channel, and port and starboard channels; uncorrected port channel, starboard channel, and port and starboard channels, and a 3.5-kHz tuned-transducer record of the bottom. Fish height or the altitude above the bottom was recorded on a strip-chart recorder. Distance of the fish from the ship (slant range) was recorded by use of a sled-mounted 4.5-kHz transducer.Data recorded on sonograms lagged the 3.5-kHz tuned-transducer record and ship navigational fix by as much as 1 hour (2 km) owing to tow-cable length (up to 5 km). Navigation of the ship was by Loran-C at a 5-minute fix interval, supplemented by satellite fixes.Data are of excellent quality and bottom features several meters high and about 6-12 m wide can be identified. Figures 1 and 2 show the location of track lines in the Manteo (NI 18-2) quadrangle just east of Cape Hatteras where the upper slope within proposed lease tract areas was surveyed. Figures 3 and 4 show track lines in the Cape Fear (NI 18-7) and contiguous quandrangles where data were recorded over the outer Blake Plateau, the Continental Slope, and the upper Continental Rise.The original records may be examined at the U.S. Survey, Woods Hole, MA 02543. Microfilm copies of the data are available for purchase only from the National Geophysical and Solar-Terrestrial Data c,nt er, NOAA/EDIS/NGSDC, Code D621, 325 Broadway, Boulder, CO 80303 (303-497-6338).

Knowledge, usage and barriers associated with contact lens wear in Ghana.

PubMed

Abokyi, Samuel; Manuh, George; Otchere, Heinz; Ilechie, Alex

2017-10-01

Despite findings that contact lens wear for vision correction provides better quality of life than spectacles, contact lens use in developing countries is low. This study evaluated knowledge, usage and barriers associated with contact lens wear among spectacle wearers in Cape Coast, Ghana. A cross-sectional survey using a structured questionnaire was conducted on an adult population of spectacle wearers to assess their knowledge of contact lens wear for vision correction. The participants were proportionately sampled from three eye clinics in the Cape Coast Metropolis, Ghana. Questionnaires were either self-administered or completed with the help of a research assistant. Of the 422 participants, only 147 (34.8%) knew of contact lens wear for vision correction. The proportion of spectacle wearers reporting history of contact lens wear was 14 (3.3%). Barriers to contact lens wear reported were satisfaction with vision through spectacles 102 (25.0%), lack of adequate information 111 (27.2%), fear of side effects 94 (23.0%) and cost 78 (19.1%). The younger adults and those with higher number of changes of spectacles were more likely to know of contact lenses. Knowledge and usage of contact lenses among spectacle wearers was low. Contact lens education and demonstration of visual performance through fitting of trial contact lenses on potential candidates may help overcome barriers to contact lens wear. Published by Elsevier Ltd.

Increased perceived self-efficacy facilitates the extinction of fear in healthy participants

PubMed Central

Zlomuzica, Armin; Preusser, Friederike; Schneider, Silvia; Margraf, Jürgen

2015-01-01

Self-efficacy has been proposed as an important element of a successful cognitive behavioral treatment (CBT). Positive changes in perceived self-efficacy have been linked to an improved adaptive emotional and behavioral responding in the context of anxiety-provoking situations. Furthermore, a positive influence of increased self-efficacy on cognitive functions has been confirmed. The present study examined the effect of verbal persuasion on perceived self-efficacy and fear extinction. Healthy participants were subjected to a standardized differential fear conditioning paradigm. After fear acquisition, half of the participants received a verbal persuasion aimed at increasing perceived self-efficacy. The extinction of fear was assessed immediately thereafter on both the implicit and explicit level. Our results suggest that an increased perceived self-efficacy was associated with enhanced extinction, evidenced on the psychophysiological level and accompanied by more pronounced decrements in conditioned negative valence. Changes in extinction were not due to a decrease in overall emotional reactivity to conditioned stimuli (CS). In addition, debriefing participants about the false positive feedback did not affect the processing of already extinguished conditioned responses during a subsequent continued extinction phase. Our results suggest that positive changes in perceived self-efficacy can be beneficial for emotional learning. Findings are discussed with respect to strategies aimed at increasing extinction learning in the course of exposure-based treatments. PMID:26528152

29 CFR 1614.705 - Comparative data-all Federal agencies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Comparative data-all Federal agencies. 1614.705 Section 1614.705 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) § 1614.705 Comparative data—all Federal agencies...

29 CFR 1614.705 - Comparative data-all Federal agencies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Comparative data-all Federal agencies. 1614.705 Section 1614.705 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) § 1614.705 Comparative data—all Federal agencies...

29 CFR 1614.705 - Comparative data-all Federal agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Comparative data-all Federal agencies. 1614.705 Section 1614.705 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) § 1614.705 Comparative data—all Federal agencies...

29 CFR 1614.705 - Comparative data-all Federal agencies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Comparative data-all Federal agencies. 1614.705 Section 1614.705 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) § 1614.705 Comparative data—all Federal agencies...

29 CFR 1614.705 - Comparative data-all Federal agencies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Comparative data-all Federal agencies. 1614.705 Section 1614.705 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION... Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) § 1614.705 Comparative data—all Federal agencies...

4 CFR 7.1 - Labor management relations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Labor management relations. 7.1 Section 7.1 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM PERSONNEL RELATIONS AND SERVICES § 7.1 Labor management relations. (a) Policy. Each employee of GAO has the right, freely and without fear of penalty or reprisal...

Treatment Controversies in Autism

ERIC Educational Resources Information Center

Schreibman, Laura

2008-01-01

With the increasing numbers of children who are being diagnosed with an autism spectrum disorder there are a wide variety of treatment approaches being marketed to vulnerable parents who are desperate to help their child. However, many of these approaches have not been rigorously evaluated and can lead to false hopes, unreasonable fears, or…

Understanding Communication Preferences of College Students with Visual Disabilities

ERIC Educational Resources Information Center

Myers, Karen A.; Bastian, Joni J.

2010-01-01

Increased enrollment of college students with disabilities raises concerns regarding appropriate communication. Faculty and administrators' lack of knowledge, false assumptions, and fear of the unknown may lead to an inequitable educational experience for students with visual disabilities. The purpose of this qualitative study was to determine the…

25 CFR 11.454 - Domestic violence.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Domestic violence. 11.454 Section 11.454 Indians BUREAU... ORDER CODE Criminal Offenses § 11.454 Domestic violence. (a) A person who commits domestic violence by inflicting physical harm, bodily injury, or sexual assault, or inflicting the fear of imminent physical harm...

25 CFR 11.454 - Domestic violence.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Domestic violence. 11.454 Section 11.454 Indians BUREAU... ORDER CODE Criminal Offenses § 11.454 Domestic violence. (a) A person who commits domestic violence by inflicting physical harm, bodily injury, or sexual assault, or inflicting the fear of imminent physical harm...

25 CFR 11.454 - Domestic violence.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Domestic violence. 11.454 Section 11.454 Indians BUREAU... ORDER CODE Criminal Offenses § 11.454 Domestic violence. (a) A person who commits domestic violence by inflicting physical harm, bodily injury, or sexual assault, or inflicting the fear of imminent physical harm...

46 CFR 7.15 - Massachusetts Bay, MA.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

46 CFR 7.15 - Massachusetts Bay, MA.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

46 CFR 7.15 - Massachusetts Bay, MA.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

46 CFR 7.15 - Massachusetts Bay, MA.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

46 CFR 7.15 - Massachusetts Bay, MA.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

50 CFR 660.385 - Washington coastal tribal fisheries management measures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... tribal allocation is 694 mt per year. This allocation is, for each year, 10 percent of the Monterey... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Washington coastal tribal fisheries... rockfish off Washington State, a harvest guideline of: 30,000 lb (13,608 kg) north of Cape Alava, WA (48°10...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

46 CFR 7.180 - Kotzebue Sound, AK.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Kotzebue Sound, AK. 7.180 Section 7.180 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Alaska § 7.180 Kotzebue Sound, AK. A line drawn from Cape Espenberg Light to latitude 66°52′ N. longitude 163°28′ W.; and...

Soothing and balmy, cure without disfigurement: Benjamin Bye, false promises, and head and neck cancer.

PubMed

Xu, Jennifer; Shuman, Andrew G

2015-04-01

One century ago, patients dreaded a diagnosis of head and neck cancer, fearing not only the progression of the disease but also the prospect of surgery. A cadre of charlatans preyed upon these fears to make a profit. We unearth the tale of Benjamin Bye, an Indianapolis doctor peddling the Combination Oil Cure. His collection of creams applied to the face offered unsuspecting patients a painless cure of their head and neck cancer. Bye eventually came under the fire of muckrakers as well as the federal government. Not long thereafter, Bye's practice was declared fraudulent, and the US Postmaster General refused to send his products. Bye's story recalls a time in which curative options were few and fear of malignancy was pervasive. Today, as our treatment armamentarium grows, we are reminded to critically assess efficacy, honestly discuss options with patients, and ensure that charlatanism remains a shadow of the past. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

Impacts of storms on coastal circulation in Long Bay, South Carolina

NASA Astrophysics Data System (ADS)

Kim, H.; Warner, J. C.; Voulgaris, G.; Work, P.

2006-12-01

We investigate the effects of coastal storms on the regional circulation in Long Bay, South Carolina, using a coupled ROMS (Regional Ocean Modeling System)- SWAN (Simulating WAves Nearshore) model. Meteorological observations during the South Carolina Coastal Erosion Study (October 2003 April 2004) reveal three dominant types of storms in the region warm fronts, cold fronts, and tropical storms. Each storm has a characteristic progression of wind patterns: (1) Warm fronts start with southwestward winds and change to northeastward after the front passes; (2) Cold fronts begin with northeastward winds and shift to southeastward when the front moves out; and (3) Tropical storms change wind directions from the southwest to the southeast during the storm. It is observed the coastal circulation distinctly responds to such atmospheric disturbances in either a upwelling-favorable condition to the northeastward winds or a downwelling-favorable condition to the southwestward winds. The study domain encompasses 300-km of gently arcing shoreline between Cape Romain to Cape Fear, and approximately 100-km offshore to the shelf edge. The model domain is resolved by a 300×130 mesh at 1-km intervals in the horizontal and twenty terrain-following layers in the vertical. The ROMS model is driven by tides and wind stress, and it includes wave-current interactions via dynamic coupling to the surface wave model SWAN. Salinity and temperature along the open boundaries are included by nudging to climatological values. A time period of six months is simulated from October 2003 to April 2004, concurrent with the observation study. Model results are compared to an extensive set of measurements collected at eight sites in the inner part of Long Bay, and are used to identify varying circulation response to each storm type. In addition, we investigate the significance of the Capes on the development of the alongshore pressure gradients, and examine the importance of wave-current interactions in the study region.

E-4 Central Kentucky to the Carolina Trough

USGS Publications Warehouse

Rankin, Douglas W.; Dillon, William P.; Black, D.F.B.; Boyer, S.E.; Daniels, David L.; Goldsmith, R.; Grow, J.A.; Horton, J. Wright; Hutchinson, Deborah R.; Klitgord, Kim D.; McDowell, R.C.; Milton, D.J.; Owens, J.P.; Phillips, Jeffrey D.; Bayer, K.C.; Butler, John R.; Elliott, D.W.; Milici, Robert C.

1991-01-01

E-4 is one of eight Geodynamics transects that cross the Atlantic margin of North America between Georgia and Newfoundland. Five of the transects are in the United States and three are in Canada. Transect E-4, which is 110 km wide and more than 1,100 km long, extends from the stable North American craton just west of the Grenville front near Lexington, Kentucky southeastward across Cape Fear, North Carolina, on the Atlantic coast to oceanic crust east of the Blake Spur magnetic anomaly. Like all of the other U.S. Atlantic coast transects, it crosses Cambrian and Jurassic continental margins of North America as well as the Appalachian orogen. The display, based upon published information, portrays the geology, tectonic style and geophysical expression of this segment of the eastern North American continental margin and interprets its Phanerozoic history. The Decade of North American Geology 1983 geologic time scale (Palmer, 1983) is used throughout the display and text.

Layers of 'Cape Verde' in 'Victoria Crater' (Enhanced)

NASA Technical Reports Server (NTRS)

2006-01-01

This view of Victoria crater is looking north from 'Duck Bay' towards the dramatic promontory called 'Cape Verde.' The dramatic cliff of layered rocks is about 50 meters (about 165 feet) away from the rover and is about 6 meters (about 20 feet) tall. The taller promontory beyond that is about 100 meters (about 325 feet) away, and the vista beyond that extends away for more than 400 meters (about 1300 feet) into the distance. This is a false color rendering (enhanced to bring out details from within the shadowed regions of the scene) of images taken by the panoramic camera (Pancam) on NASA's Mars Exploration Rover Opportunity during the rover's 952nd sol, or Martian day, (Sept. 28, 2006) using the camera's 750-nanometer, 530-nanometer and 430-nanometer filters.

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

Anatomy of a shoreface sand ridge revisited using foraminifera: False Cape Shoals, Virginia/North Carolina inner shelf

USGS Publications Warehouse

Robinson, M.M.; McBride, R.A.

2008-01-01

Certain details regarding the origin and evolution of shelf sand ridges remain elusive. Knowledge of their internal stratigraphy and microfossil distribution is necessary to define the origin and to determine the processes that modify sand ridges. Fourteen vibracores from False Cape Shoal A, a well-developed shoreface-attached sand ridge on the Virginia/North Carolina inner continental shelf, were examined to document the internal stratigraphy and benthic foraminiferal assemblages, as well as to reconstruct the depositional environments recorded in down-core sediments. Seven sedimentary and foraminiferal facies correspond to the following stratigraphic units: fossiliferous silt, barren sand, clay to sandy clay, laminated and bioturbated sand, poorly sorted massive sand, fine clean sand, and poorly sorted clay to gravel. The units represent a Pleistocene estuary and shoreface, a Holocene estuary, ebb tidal delta, modern shelf, modern shoreface, and swale fill, respectively. The succession of depositional environments reflects a Pleistocene sea-level highstand and subsequent regression followed by the Holocene transgression in which barrier island/spit systems formed along the Virginia/North Carolina inner shelf ???5.2 ka and migrated landward and an ebb tidal delta that was deposited, reworked, and covered by shelf sand.

Anatomy of a shoreface sand ridge revisted using foraminifera: False Cape Shoals, Virginia/North Carolina inner shelf

USGS Publications Warehouse

Robinson, Marci M.; McBride, Randolph A.

2008-01-01

Certain details regarding the origin and evolution of shelf sand ridges remain elusive. Knowledge of their internal stratigraphy and microfossil distribution is necessary to define the origin and to determine the processes that modify sand ridges. Fourteen vibracores from False Cape Shoal A, a well-developed shoreface-attached sand ridge on the Virginia/North Carolina inner continental shelf, were examined to document the internal stratigraphy and benthic foraminiferal assemblages, as well as to reconstruct the depositional environments recorded in down-core sediments. Seven sedimentary and foraminiferal facies correspond to the following stratigraphic units: fossiliferous silt, barren sand, clay to sandy clay, laminated and bioturbated sand, poorly sorted massive sand, fine clean sand, and poorly sorted clay to gravel. The units represent a Pleistocene estuary and shoreface, a Holocene estuary, ebb tidal delta, modern shelf, modern shoreface, and swale fill, respectively. The succession of depositional environments reflects a Pleistocene sea-level highstand and subsequent regression followed by the Holocene transgression in which barrier island/spit systems formed along the Virginia/North Carolina inner shelf not, vert, ~5.2 ka and migrated landward and an ebb tidal delta that was deposited, reworked, and covered by shelf sand.

Longitudinal Variation in Paleo-channel Complex Geometry and Associated Fill: Offshore South Carolina

NASA Astrophysics Data System (ADS)

Long, A. M.; Hill, J. C.

2017-12-01

In northeastern South Carolina, several shallow (<25 m deep) paleo-channel complexes have previously been interpreted as the result of the southward migration of the ancestral Pee Dee River system along the southern limb of the Cape Fear Arch since the Pliocene. These paleo-channel complexes can be traced 80 km across the continental shelf via Boomer and Chirp subbottom data. The Murrells Inlet paleo-channel complex is the most well imaged offshore; and this data coverage provides an opportunity for a detailed seismic stratigraphic interpretation and analysis of downstream variability. Initial observations from this case study indicate that inner shelf incisions, where bedrock is folded and faulted, tend to be shallow with numerous channels, while the incisions across the middle shelf appear to be deeper and contains larger, more sinuous channels that are cut into broadly tilted strata with a gentle south-southeastward dip. This suggests the geometry and spatial distribution of the incisions were a function of the inherited fabric of the underlying basement, which created local deflection and areas of aggradation and degradation. The inner shelf paleo-channel complex fill is dominated by fluvial cut and fill seismic facies, while the middle shelf contains a wide variety of seismic facies (i.e. transparent, layered, chaotic, etc). This overall longitudinal fill pattern is most likely due to each location's general proximity to base level. The variation in the cut and fill seismic facies may be driven by substantial changes in discharge, driven locally by the joining of another major river or by climatic changes in the drainage basin. There also appears to be preferential reoccupation of previously filled paleo-channels, as the basement in this region is Tertiary and Cretaceous carbonates and siliciclastic rocks that are more resistant to erosion. The most recent occupation in any given paleo-channel tends to be on the southern margin, which may imply tectonic forcing from the uplift of the Cape Fear Arch. Preliminary results from this case study suggest that first order controls on the position and geometry of the paleo-channel complexes appears to be largely allogenic (i.e. tectonic and base level driven), while the depositional history of the fill may have been a mix of autogenic and allogenic processes.

Hydrogeology and Simulation of Ground-Water Flow near Mount Pleasant, South Carolina--Predevelopment, 2004, and Predicted Scenarios for 2030

USGS Publications Warehouse

Petkewich, Matthew D.; Campbell, Bruce G.

2007-01-01

Heavy water use from the Cretaceous Middendorf aquifer in South Carolina has created a large, regional cone of depression in the potentiometric surface of the Middendorf aquifer in Charleston and Berkeley Counties, South Carolina. Water-level declines of up to 249 feet have been observed in wells over the past 125 years and are a result of ground-water use for public-water supply, irrigation, and private industry. To address the concerns of users of the Middendorf aquifer, the U.S. Geological Survey, in cooperation with Mount Pleasant Waterworks, updated an existing ground-water flow model to incorporate additional data that have been compiled since 1989. The updated ground-water flow model incorporates water-level data collected from 349 wells in 2004, baseflow data measured at 17 streams, hydraulic property data from 265 wells, and water-use data compiled for more than 2,700 wells for the period between the early 1900s to 2004. The ground-water flow system of the Coastal Plain physiographic province of South Carolina and parts of Georgia and North Carolina was simulated using the U.S. Geological Survey finite-difference code MODFLOW-2000. The model was vertically discretized into nine layers to include the five aquifers of the surficial, the combined Floridan aquifer system and Tertiary sand aquifer, Black Creek, Middendorf, and Cape Fear, separated by four intervening confining units. Specified-head boundary conditions were used at the lateral boundaries of the model and for the lower Coastal Plain part of the surficial aquifer; no-flow boundary conditions were used at the updip and downdip extent of the model layers and at the base of the Cape Fear aquifer. Ground-water conditions for predevelopment and 2004 were simulated using steady-state and transient approximations, respectively. Simulated water levels generally matched the observed conditions, plus or minus a 20-foot calibration target, with 56.4 and 64.8 percent of the simulated values approximating the measured values for predevelopment and 2004 hydrologic conditions, respectively. The root-mean-square error of the water-level residuals for the various model layers varied between 20.2 and 34.4 feet for predevelopment and 18.2 and 36.7 feet for 2004. The general goodness of fit also was apparent in the calculation of the ratio of standard deviation of residuals to range of observations for each modeled aquifer layer. The calculated ratios for the predevelopment and 2004 hydrologic conditions were less than 0.10 for all model layers except for the Cape Fear aquifer in both predevelopment and 2004 simulations. The Mount Pleasant model was most sensitive to changes in simulated specific storage of most model layers, vertical anisotropy of the confining units above and below the Middendorf aquifer, hydraulic conductivity of the confining units, and the specified-head boundary conditions for the surficial aquifer. The model also is sensitive to horizontal hydraulic conductivity of the Floridan aquifer system and Tertiary sand aquifer and the Black Creek and Middendorf aquifers. Simulated water budgets indicate that the primary sources of water to the model are recharge and the specified-head boundaries in layers 1 and 3. More than 88 percent of the water that discharges from the model discharges from layers 1-3 through specified-head boundaries and rivers. Approximately 11 percent of the water budget was discharged through wells for the 2004 budget. In 2004, 8.11 million gallons of water per day was discharged from wells in the Mount Pleasant area. Water to these wells is provided predominantly by lateral flow within the Middendorf aquifer. Additional water is provided from aquifer storage and leakage from confining units located above and below the Middendorf aquifer. Downward flow through the Middendorf confining unit is a reversal of the predevelopment flow direction. Five predictive water-management scenarios were simulated to determine the effects on the

29 CFR 1614.706 - Other data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Other data. 1614.706 Section 1614.706 Labor Regulations... 2002 (No FEAR Act) § 1614.706 Other data. Agencies shall not include or otherwise post with the data required to be posted under § 1614.704 and 1614.705 of this subpart any other data, whether or not EEO...

29 CFR 1614.706 - Other data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Other data. 1614.706 Section 1614.706 Labor Regulations... 2002 (No FEAR Act) § 1614.706 Other data. Agencies shall not include or otherwise post with the data required to be posted under § 1614.704 and 1614.705 of this subpart any other data, whether or not EEO...

29 CFR 1614.706 - Other data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Other data. 1614.706 Section 1614.706 Labor Regulations... 2002 (No FEAR Act) § 1614.706 Other data. Agencies shall not include or otherwise post with the data required to be posted under § 1614.704 and 1614.705 of this subpart any other data, whether or not EEO...

29 CFR 1614.706 - Other data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Other data. 1614.706 Section 1614.706 Labor Regulations... 2002 (No FEAR Act) § 1614.706 Other data. Agencies shall not include or otherwise post with the data required to be posted under § 1614.704 and 1614.705 of this subpart any other data, whether or not EEO...

29 CFR 1614.706 - Other data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Other data. 1614.706 Section 1614.706 Labor Regulations... 2002 (No FEAR Act) § 1614.706 Other data. Agencies shall not include or otherwise post with the data required to be posted under § 1614.704 and 1614.705 of this subpart any other data, whether or not EEO...

Anxiety sensitivity and auditory perception of heartbeat.

PubMed

Pollock, R A; Carter, A S; Amir, N; Marks, L E

2006-12-01

Anxiety sensitivity (AS) is the fear of sensations associated with autonomic arousal. AS has been associated with the development and maintenance of panic disorder. Given that panic patients often rate cardiac symptoms as the most fear-provoking feature of a panic attack, AS individuals may be especially responsive to cardiac stimuli. Consequently, we developed a signal-in-white-noise detection paradigm to examine the strategies that high and low AS individuals use to detect and discriminate normal and abnormal heartbeat sounds. Compared to low AS individuals, high AS individuals demonstrated a greater propensity to report the presence of normal, but not abnormal, heartbeat sounds. High and low AS individuals did not differ in their ability to perceive normal heartbeat sounds against a background of white noise; however, high AS individuals consistently demonstrated lower ability to discriminate abnormal heartbeats from background noise and between abnormal and normal heartbeats. AS was characterized by an elevated false alarm rate across all tasks. These results suggest that heartbeat sounds may be fear-relevant cues for AS individuals, and may affect their attention and perception in tasks involving threat signals.

3 CFR 8949 - Proclamation 8949 of March 29, 2013. National Child Abuse Prevention Month, 2013

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Proclamation 8949 of March 29, 2013. National Child... 8949 of March 29, 2013 Proc. 8949 National Child Abuse Prevention Month, 2013By the President of the... own measure of happiness and live free from fear. But for the millions of children who have...

Feedback training induces a bias for detecting happiness or fear in facial expressions that generalises to a novel task.

PubMed

Griffiths, Sarah; Jarrold, Chris; Penton-Voak, Ian S; Munafò, Marcus R

2015-12-30

Many psychological disorders are characterised by insensitivities or biases in the processing of subtle facial expressions of emotion. Training using expression morph sequences which vary the intensity of expressions may be able to address such deficits. In the current study participants were shown expressions from either happy or fearful intensity morph sequences, and trained to detect the target emotion (e.g., happy in the happy sequence) as being present in low intensity expressions. Training transfer was tested using a six alternative forced choice emotion labelling task with varying intensity expressions, which participants completed before and after training. Training increased false alarms for the target emotion in the transfer task. Hit rate for the target emotion did not increase once adjustment was made for the increase in false alarms. This suggests that training causes a bias for detecting the target emotion which generalises outside of the training task. However it does not increase accuracy for detecting the target emotion. The results are discussed in terms of the training's utility in addressing different types of emotion processing deficits in psychological disorders. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

A comparison of American Oystercatcher reproductive success on barrier beach and river island habitats in coastal North Carolina

USGS Publications Warehouse

McGowan, C.P.; Simons, T.R.; Golder, W.; Cordes, J.

2005-01-01

American Oystercatcher (Haematopus palliatus) numbers along the east coast of the United States are declining in some areas and expanding in others. Researchers have suggested that movement from traditional barrier beach habitats to novel inland habitats and coastal marshes may explain some of these changes, but few studies have documented oystercatcher reproductive success in non-traditional habitats. This study compares the reproductive success of the American Oystercatcher on three river islands in the lower Cape Fear River of North Carolina with that of birds nesting on barrier island beach habitat of Cape Lookout National Seashore. There were 17.6 times more oystercatcher breeding pairs per kilometer on the river island habitat than barrier beach habitat. The Mayfield estimate of daily nest content survival was 0.97 (S.E. ?? 0.0039) on river islands, significantly higher than 0.92 (S.E. ?? 0.0059) on barrier islands. The primary identifiable cause of nest failure on the river islands was flooding while the main cause of nest failure on the barrier islands was mammalian predation. Fledging success was equally low at both study sites. Only 0.19 chicks fledged per pair in 2002, and 0.21 chicks fledged per pair in 2003 on the river islands and 0.14 chicks fledged per pair in 2002 and 0.20 chicks fledged per pair in 2003 on the barrier islands. Many questions are still unanswered and more research is needed to fully understand the causes of chick mortality and the functional significance of non-traditional nesting habitats for the American Oystercatcher in the eastern United States.

False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences.

PubMed

Piketty, Marie-Liesse; Polak, Michel; Flechtner, Isabelle; Gonzales-Briceño, Laura; Souberbielle, Jean-Claude

2017-05-01

Immunoassays are now commonly used for hormone measurement, in high throughput analytical platforms. Immunoassays are generally robust to interference. However, endogenous analytical error may occur in some patients; this may be encountered in biotin supplementation or in the presence of anti-streptavidin antibody, in immunoassays involving streptavidin-biotin interaction. In these cases, the interference may induce both false positive and false negative results, and simulate a seemingly coherent hormonal profile. It is to be feared that this type of errors will be more frequently observed. This review underlines the importance of keeping close interactions between biologists and clinicians to be able to correlate the hormonal assay results with the clinical picture.

South Africa, Namibia, and Botswana

NASA Technical Reports Server (NTRS)

2002-01-01

Pale green vegetation and red-brown deserts dominate this MODIS image of Namibia (left), Botswana (upper right), and the Republic of South Africa (bottom) acquired on June3, 2002. In central Namibia the mountainous terrain of Namaqualand is sandwiched between the Namib Desert on the Atlantic Coast and the Kalahari Desert to the interior, where white dots mark the location of small, impermanent lakes and ponds. Namaqualand is home to numerous rare succulent plants that can survive on the region.s scant rainfall as well as fog that blows in off the ocean. Namaqualand extends south of the Orange River, which runs along the border of Namibia and South Africa and into that country.s Northern Cape region. The Orange River extends almost all the way back through the country, and where it makes a sharp southward dip in this image (at lower right), it runs through the Asbestos Mountains, names for the naturally-occurring asbestos they contain. In southwestern South Africa, high plateaus, such as the Great Karoo become mountain ridges near the coast, and the city of Cape Town is visible as a grayish area of pixels on the north shores of the horseshoe-shaped False Bay at the Cape of Good Hope. Credit: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

Stratigraphic and palaeoenvironmental summary of the south-east Georgia Embayment: a correlation of exploratory wells

USGS Publications Warehouse

Poppe, L.J.; Popenoe, P.; Poag, C.W.; Swift, B.A.

1995-01-01

A Continental Offshore Stratigraphic Test (COST) well and six exploratory wells have been drilled in the south-east Georgia embayment. The oldest rocks penetrated are weakly metamorphosed Lower Ordovician quartz arenites and Silurian shales and argillites in the Transco 1005-1 well and Upper Devonian argillites in the COST GE-1 well. The Palaeozoic strata are unconformably overlain by interbedded non-marine Jurassic sandstones and shales and marginal marine Lower Cretaceous rocks. Together, these rocks are stratigraphically equivalent to the onshore Fort Pierce and Cotton Valley(?) Formations and rocks of the Lower Cretaceous Comanchean Provincial Series. The Upper Cretaceous part of the section is composed mainly of neritic calcareous shales and shaley limestones stratigraphically equivalent to the primarily marginal marine facies of the onshore Atkinson, Cape Fear and Middendorf Formations and Black Creek Group, and to limestones and shales of the Lawson Limestone and Peedee Formations. Cenozoic strata are also described. -from Authors

The effect of channel deepening on tides and storm surge: A case study of Wilmington, NC

NASA Astrophysics Data System (ADS)

Familkhalili, R.; Talke, S. A.

2016-09-01

In this study we investigate the hypothesis that increasing channel depth in estuaries can amplify both tides and storm surge by developing an idealized numerical model representing the 1888, 1975, and 2015 bathymetric conditions of the Cape Fear River Estuary, NC. Archival tide gauge data recovered from the U.S. National Archives indicates that mean tidal range in Wilmington has doubled to 1.55 m since the 1880s, with a much smaller increase of 0.07 m observed near the ocean boundary. These tidal changes are reproduced by simulating channel depths of 7 m (1888 condition) and 15.5 m (modern condition). Similarly, model sensitivity studies using idealized, parametric tropical cyclones suggest that the storm surge in the worst-case, CAT-5 event may have increased from 3.8 ± 0.25 m to 5.6 ± 0.6 m since the nineteenth century. The amplification in both tides and storm surge is influenced by reduced hydraulic drag caused by greater mean depths.

My secret: the social meaning of HIV/AIDS stigma.

PubMed

Judgeo, N; Moalusi, K P

2014-01-01

This study uses Goffman's [1963. Stigma: Notes on the Management of Spoiled Identity, New Jersey, Prentice-Hall] theory of stigma as an intellectual scaffold to help understand the social meaning of HIV/AIDS stigma from People Living with HIV/AIDS. The study adopts a qualitative approach because of its appropriateness for unravelling subjective phenomena such as the experiences of HIV/AIDS stigma. In-depth interviews were conducted with 10 HIV-positive employees of a retailing company located in the Western Cape province of South Africa who volunteered to participate in the study. The participants with the discreditable stigma internalised society's prejudice towards those living with the virus. As a result, the participants relied on self-isolation and social withdrawal to cope with enacted stigma. Managing information about one's status and deciding whether, who, when, etc., to tell are crucial questions. The participants feared being devalued by family, friends, co-workers and the community. In concurrence with Goffman [1963], the HIV/AIDS stigma is seen as about relationships.

76 FR 38302 - Safety Zone; Cape Charles Fireworks, Cape Charles Harbor, Cape Charles, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... the Town of Cape Charles will sponsor a fireworks display on the shoreline of the navigable waters of...-AA00 Safety Zone; Cape Charles Fireworks, Cape Charles Harbor, Cape Charles, VA AGENCY: Coast Guard... navigable waters of Cape Charles City Harbor in Cape Charles, VA in support of the Fourth of July Fireworks...

Emotional expression recognition and attribution bias among sexual and violent offenders: a signal detection analysis

PubMed Central

Gillespie, Steven M.; Rotshtein, Pia; Satherley, Rose-Marie; Beech, Anthony R.; Mitchell, Ian J.

2015-01-01

Research with violent offenders has consistently shown impaired recognition of other’s facial expressions of emotion. However, the extent to which similar problems can be observed among sexual offenders remains unknown. Using a computerized task, we presented sexual and violent offenders, and non-offenders, with male and female expressions of anger, disgust, fear, happiness, sadness, and surprise, morphed with neutral expressions at varying levels of intensity (10, 55, and 90% expressive). Based on signal detection theory, we used hit rates and false alarms to calculate the sensitivity index d-prime (d′) and criterion (c) for each emotional expression. Overall, sexual offenders showed reduced sensitivity to emotional expressions across intensity, sex, and type of expression, compared with non-offenders, while both sexual and violent offenders showed particular reduced sensitivity to fearful expressions. We also observed specific effects for high (90%) intensity female faces, with sexual offenders showing reduced sensitivity to anger compared with non-offenders and violent offenders, and reduced sensitivity to disgust compared with non-offenders. Furthermore, both sexual and violent offenders showed impaired sensitivity to high intensity female fearful expressions compared with non-offenders. Violent offenders also showed a higher criterion for classifying moderate and high intensity male expressions as fearful, indicative of a more conservative response style, compared with angry, happy, or sad. These results suggest that both types of offender show problems in emotion recognition, and may have implications for understanding the inhibition of violent and sexually violent behaviors. PMID:26029137

Emotional expression recognition and attribution bias among sexual and violent offenders: a signal detection analysis.

PubMed

Gillespie, Steven M; Rotshtein, Pia; Satherley, Rose-Marie; Beech, Anthony R; Mitchell, Ian J

2015-01-01

Research with violent offenders has consistently shown impaired recognition of other's facial expressions of emotion. However, the extent to which similar problems can be observed among sexual offenders remains unknown. Using a computerized task, we presented sexual and violent offenders, and non-offenders, with male and female expressions of anger, disgust, fear, happiness, sadness, and surprise, morphed with neutral expressions at varying levels of intensity (10, 55, and 90% expressive). Based on signal detection theory, we used hit rates and false alarms to calculate the sensitivity index d-prime (d') and criterion (c) for each emotional expression. Overall, sexual offenders showed reduced sensitivity to emotional expressions across intensity, sex, and type of expression, compared with non-offenders, while both sexual and violent offenders showed particular reduced sensitivity to fearful expressions. We also observed specific effects for high (90%) intensity female faces, with sexual offenders showing reduced sensitivity to anger compared with non-offenders and violent offenders, and reduced sensitivity to disgust compared with non-offenders. Furthermore, both sexual and violent offenders showed impaired sensitivity to high intensity female fearful expressions compared with non-offenders. Violent offenders also showed a higher criterion for classifying moderate and high intensity male expressions as fearful, indicative of a more conservative response style, compared with angry, happy, or sad. These results suggest that both types of offender show problems in emotion recognition, and may have implications for understanding the inhibition of violent and sexually violent behaviors.

77 FR 29929 - Safety Zone; Town of Cape Charles Fireworks, Cape Charles Harbor, Cape Charles, VA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... section of this notice. Basis and Purpose On July 4, 2012 the Town of Cape Charles will sponsor a...-AA00 Safety Zone; Town of Cape Charles Fireworks, Cape Charles Harbor, Cape Charles, VA AGENCY: Coast... temporary safety zone on the waters of Cape Charles City Harbor in Cape Charles, VA in support of the Fourth...

Risk management and precaution: insights on the cautious use of evidence.

PubMed Central

Hrudey, Steve E; Leiss, William

2003-01-01

Risk management, done well, should be inherently precautionary. Adopting an appropriate degree of precaution with respect to feared health and environmental hazards is fundamental to risk management. The real problem is in deciding how precautionary to be in the face of inevitable uncertainties, demanding that we understand the equally inevitable false positives and false negatives from screening evidence. We consider a framework for detection and judgment of evidence of well-characterized hazards, using the concepts of sensitivity, specificity, positive predictive value, and negative predictive value that are well established for medical diagnosis. Our confidence in predicting the likelihood of a true danger inevitably will be poor for rare hazards because of the predominance of false positives; failing to detect a true danger is less likely because false negatives must be rarer than the danger itself. Because most controversial environmental hazards arise infrequently, this truth poses a dilemma for risk management. PMID:14527835

76 FR 27970 - Safety Zone; Cape Charles Fireworks, Cape Charles Harbor, Cape Charles, VA.

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... Charles will sponsor a fireworks display on the shoreline of the navigable waters of Cape Charles City...[deg]01'30'' W (NAD 1983). This safety zone will be established in the vicinity of Cape Charles, VA...-AA00 Safety Zone; Cape Charles Fireworks, Cape Charles Harbor, Cape Charles, VA. AGENCY: Coast Guard...

The spread of true and false news online.

PubMed

Vosoughi, Soroush; Roy, Deb; Aral, Sinan

2018-03-09

We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted by ~3 million people more than 4.5 million times. We classified news as true or false using information from six independent fact-checking organizations that exhibited 95 to 98% agreement on the classifications. Falsehood diffused significantly farther, faster, deeper, and more broadly than the truth in all categories of information, and the effects were more pronounced for false political news than for false news about terrorism, natural disasters, science, urban legends, or financial information. We found that false news was more novel than true news, which suggests that people were more likely to share novel information. Whereas false stories inspired fear, disgust, and surprise in replies, true stories inspired anticipation, sadness, joy, and trust. Contrary to conventional wisdom, robots accelerated the spread of true and false news at the same rate, implying that false news spreads more than the truth because humans, not robots, are more likely to spread it. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Summer at the beach: spatio-temporal patterns of white shark occurrence along the inshore areas of False Bay, South Africa.

PubMed

Kock, Alison A; Photopoulou, Theoni; Durbach, Ian; Mauff, Katya; Meÿer, Michael; Kotze, Deon; Griffiths, Charles L; O'Riain, M Justin

2018-01-01

Understanding white shark ( Carcharodon carcharias ) habitat use in coastal areas adjacent to large cities, is an important step when formulating potential solutions to the conservation conflict that exists between humans and large predatory sharks. In this study, we present the findings of a 2.5-year study of white shark occurrence and movement patterns adjacent to the City of Cape Town in False Bay, South Africa, with a focus on spring and summer months. Fifty-one white sharks were monitored annually at three offshore and twelve inshore sites by VR2 acoustic receivers, over 975 days from 1 May 2005 to 31 December 2007. Occurrence patterns at inshore sites during spring and summer were analysed using a generalized additive mixed model (GAMM) with a spatial term (longitude, latitude), time of day and year included as explanatory variables for site use. We found that sharks occurred more frequently at inshore sites along the northern and northwestern shores, compared to the rest of the bay, and they transitioned most frequently between four adjacent beach sites that encompass the most popular recreational water use areas in Cape Town. There was significant diel variation, with higher shark occurrence around midday, and a peak in shark occurrence in 2005, when human-shark interactions also peaked. However, we found no effect of shark size on occurrence patterns at inshore sites. White sharks showed the highest levels of occurrence at specific inshore sites between Muizenberg and Strandfontein beach, and thus inclusion of these sites within False Bay's marine protected area (MPA) network or recognition as Ecological or Biological Significant Areas (EBSAs) should be a future consideration. These insights into white shark habitat use at inshore sites in False Bay are important for successfully applying the principles of marine spatial planning (MSP) and for making science-based policy decisions. Furthermore, this information can be used to reduce potential shark-human conflict by incorporating it into future shark safety education campaigns.

Adults' memories of childhood: true and false reports.

PubMed

Qin, Jianjian; Ogle, Christin M; Goodman, Gail S

2008-12-01

In 3 experiments, the authors examined factors that, according to the source-monitoring framework, might influence false memory formation and true/false memory discernment. In Experiment 1, combined effects of warning and visualization on false childhood memory formation were examined, as were individual differences in true and false childhood memories. Combining warnings and visualization led to the lowest false memory and highest true memory. Several individual difference factors (e.g., parental fearful attachment style) predicted false recall. In addition, true and false childhood memories differed (e.g., in amount of information). Experiment 2 examined relations between Deese/Roediger-McDermott task performance and false childhood memories. Deese/Roediger-McDermott performance (e.g., intrusion of unrelated words in free recall) was associated with false childhood memory, suggesting liberal response criteria in source decisions as a common underlying mechanism. Experiment 3 investigated adults' abilities to discern true and false childhood memory reports (e.g., by detecting differences in amount of information as identified in Experiment 1). Adults who were particularly successful in discerning such reports indicated reliance on event plausibility. Overall, the source-monitoring framework provided a viable explanatory framework. Implications for theory and clinical and forensic interviews are discussed. PsycINFO Database Record (c) 2008 APA, all rights reserved.

Trustworthy Tricksters: Violating a Negative Social Expectation Affects Source Memory and Person Perception When Fear of Exploitation Is High

PubMed Central

Süssenbach, Philipp; Gollwitzer, Mario; Mieth, Laura; Buchner, Axel; Bell, Raoul

2016-01-01

People who are high in victim-sensitivity—a personality trait characterized by a strong fear of being exploited by others—are more likely to attend to social cues associated with untrustworthiness rather than to cues associated with trustworthiness compared with people who are low in victim-sensitivity. But how do these people react when an initial expectation regarding a target’s trustworthiness turns out to be false? Results from two studies show that victim-sensitive compared with victim-insensitive individuals show enhanced source memory and greater change in person perception for negatively labeled targets that violated rather than confirmed negative expectations (the “trustworthy trickster”). These findings are in line with recent theorizing on schema inconsistency and expectancy violation effects in social cognition and with research on the different facets of justice sensitivity in personality psychology. PMID:28082945

Morphodynamics and Geology of the Southeastern Virginia Shelf: False Cape Shoals Area (Phase 2)

DTIC Science & Technology

2001-09-30

Code 322PO Randolph A. McBride, Ph.D. Assistant Professor of Geology Environmental Science and Policy, MS 5F2 George Mason University Fairfax...NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Environmental Science and Policy, MS 5F2,,George Mason...Geology Laboratory at George Mason University. In addition, a Ph.D. student in Environmental Science and Policy, who is working under the direction

Anguilliform larvae collected off North Carolina

USGS Publications Warehouse

Ross, Steve W.; Casazza, T.L.; Quattrini, A.M.; Sulak, K.J.

2007-01-01

The distinctive larval stage of eels (leptocephalus) facilitates dispersal through prolonged life in the open ocean. Leptocephali are abundant and diverse off North Carolina, yet data on distributions and biology are lacking. The water column (from surface to 1,293 m) was sampled in or near the Gulf Stream off Cape Hatteras, Cape Lookout, and Cape Fear, North Carolina during summer through fall of 1999-2005, and leptocephali were collected by neuston net, plankton net, Tucker trawl, and dip net. Additional samples were collected nearly monthly from a transect across southern Onslow Bay, North Carolina (from surface to 91 m) from April 2000 to December 2001 by bongo and neuston nets, Methot frame trawl, and Tucker trawl. Overall, 584 tows were completed, and 224 of these yielded larval eels. The 1,295 eel leptocephali collected (combining all methods and areas) represented at least 63 species (nine families). Thirteen species were not known previously from the area. Dominant families for all areas were Congridae (44% of individuals, 11 species), Ophichthidae (30% of individuals, 27 species), and Muraenidae (22% of individuals, ten species). Nine taxa accounted for 70% of the overall leptocephalus catches (in order of decreasing abundance): Paraconger caudilimbatus (Poey), Gymnothorax ocellatus Agassiz complex, Ariosoma balearicum (Delaroche), Ophichthus gomesii (Castelnau), Callechelys muraena Jordan and Evermann, Letharchus aliculatus McCosker, Rhynchoconger flavus (Goode and Bean), Ophichthus cruentifer (Goode and Bean), Rhynchoconger gracilior (Ginsburg). The top three species represented 52% of the total eel larvae collected. Most leptocephali were collected at night (79%) and at depths > 45 m. Eighty percent of the eels collected in discrete depth Tucker trawls at night ranged from mean depths of 59-353 m. A substantial number (38% of discrete depth sample total) of larval eels were also collected at the surface (neuston net) at night. Daytime leptocephalus distributions were less clear partly due to low catches and lower Tucker trawl sampling effort. While net avoidance may account for some of the low daytime catches, an alternative explanation is that many species of larval eels occur during the day at depths > 350 m. Larvae of 21 taxa of typically shallow water eels were collected at depths > 350 m, but additional discrete depth diel sampling is needed to resolve leptocephalus vertical distributions. The North Carolina adult eel fauna (estuary to at least 2,000 m) consists of 51 species, 41% of which were represented in these collections. Many species of leptocephali collected are not yet known to have juveniles or adults established in the South Atlantic Bight or north of Cape Hatteras. Despite Gulf Stream transport and a prolonged larval stage, many of these eel leptocephali may not contribute to their respective populations. ?? 2006 Springer-Verlag.

Fear patterns: a new approach to designing road safety advertisements.

PubMed

Algie, Jennifer; Rossiter, John R

2010-01-01

This research studies fear patterns within fear appeal anti-speeding television commercials. A pattern of fear is the sequence of fear arousal and fear reduction, if any, that is felt by the viewing audience when exposed to a fear appeal advertisement. Many road safety advertisers use fear appeals, such as "shock" advertising, that result in fear arousal, leaving the viewer feeling extremely tense. The moment-to-moment reactions of young drivers to 12 road safety commercials are gauged using a dynamic, temporal measure of fear. The fear patterns generated from each ad are analyzed and a new perspective on creating fear appeal road safety advertisements, with an emphasis on fear-relief, fear-partial relief, and fear-only patterns, is discussed.

False Memory for Trauma-Related DRM Lists in Adolescents and Adults with Histories of Child Sexual Abuse

PubMed Central

Goodman, Gail S.; Ogle, Christin M.; Block, Stephanie D.; Harris, LaTonya S.; Larson, Rakel P.; Augusti, Else-Marie; Cho, Young Il; Beber, Jonathan; Timmer, Susan; Urquiza, Anthony

2014-01-01

The purpose of the present research was to examine Deese-Roediger-McDermott (DRM) false memory for trauma-related and nontrauma-related lists in adolescents and adults with and without documented histories of child sexual abuse (CSA). Individual differences in psychopathology and adult attachment were also explored. Participants were administered free recall and recognition tests after hearing CSA, negative, neutral, and positive DRM lists. In free recall, CSA and negative lists produced the most false memory. In sharp contrast, for recognition, CSA lists enjoyed the highest d’ scores. CSA-group adolescents who evinced greater PTSD symptoms had higher rates of false memory compared to: 1) nonCSA-group adolescents with higher PTSD symptom scores (free recall), and 2) CSA-group adolescents with lower PTSD symptom scores (recognition). Regression analyses revealed that individuals with higher PTSD scores and greater fearful-avoidant attachment tendencies showed less proficient memory monitoring for CSA lists. Implications for trauma and memory development and for translational research are discussed. PMID:23786687

First steps of integrated spatial modeling of titanium, zirconium, and rare earth element resources within the Coastal Plain sediments of the southeastern United States

USGS Publications Warehouse

Ellefsen, Karl J.; Van Gosen, Bradley S.; Fey, David L.; Budahn, James R.; Smith, Steven M.; Shah, Anjana K.

2015-01-01

The Coastal Plain of the southeastern United States has extensive, unconsolidated sedimentary deposits that are enriched in heavy minerals containing titanium, zirconium, and rare earth element resources. Areas favorable for exploration and development of these resources are being identified by geochemical data, which are supplemented with geological, geophysical, hydrological, and geographical data. The first steps of this analysis have been completed. The concentrations of lanthanum, yttrium, and titanium tend to decrease as distance from the Piedmont (which is the likely source of these resources) increases and are moderately correlated with airborne measurements of equivalent thorium concentration. The concentrations of lanthanum, yttrium, and titanium are relatively high in those watersheds that adjoin the Piedmont, south of the Cape Fear Arch. Although this relation suggests that the concentrations are related to the watersheds, it may be simply an independent regional trend. The concentration of zirconium is unrelated to the distance from the Piedmont, the equivalent thorium concentration, and the watershed. These findings establish a foundation for more sophisticated analyses using integrated spatial modeling.

The Sunny Point Formation: a new Upper Cretaceous subsurface unit in the Carolina Coastal Plain

USGS Publications Warehouse

Balson, Audra E.; Self-Trail, Jean; Terry, Dennis O.

2013-01-01

This paper formally defines the Sunny Point Formation, a new Upper Cretaceous subsurface unit confined to the outer Atlantic Coastal Plain of North and South Carolina. Its type section is established in corehole NH-C-1-2001 (Kure Beach) from New Hanover County, North Carolina. The Sunny Point Formation consists of light-olive-gray to greenish-gray, fine to coarse micaceous sands and light-olive-brown and grayish-red silty, sandy clays. The clay-rich sections typically include ironstone, lignitized wood, root traces, hematite concretions, goethite, limonite, and sphaerosiderites. The Sunny Point Formation is also documented in cores from Bladen County, North Carolina, and from Dorchester and Horry Counties, South Carolina. Previously, strata of the Sunny Point Formation had been incorrectly assigned to the Cape Fear and Middendorf Formations. The Sunny Point occupies a stratigraphic position above the Cenomanian marine Clubhouse Formation and below an upper Turonian unnamed marine unit. Contacts between these units are sharp and unconformable. Calcareous nannofossil and palynomorph analyses indicate that the Sunny Point Formation is Turonian.

The Shadow of Physical Harm? Examining the Unique and Gendered Relationship Between Fear of Murder Versus Fear of Sexual Assault on Fear of Violent Crime.

PubMed

Riggs, Samantha; Cook, Carrie L

2015-09-01

The shadow hypothesis regarding the impact of fear of sexual assault on fear of violent crime suggests that female fear of crime is characterized by concern about sexual assault as a contemporaneous victimization event during a violent crime event. Recent research has found that other types of crime, namely physical assault, may also be feared as a contemporaneous offense. We know of no research that has examined the unique impact of fear of murder versus fear of sexual assault on fear of violent crime. There is also a lack of research that explores how these two types of fear uniquely affect men and women. In addition to gender, we examine factors that have been suggested in previous research to correlate with fear of crime: race, victimization, vicarious victimization, and perceived risk. Through survey methodology, this research examines the unique relationship between both fear of murder and fear of sexual assault and fear of three types of violent crime for men and women. Results suggest differences in how fear of murder and fear of sexual assault are related to fear of other types of violence for men and women. Specifically, fear of murder is important in estimating male fear of robbery and aggravated assault. However, fear of sexual assault is almost as important as fear of murder for men in estimating fear of home invasion. Similarly, for women, fear of sexual assault and fear of murder both are significant factors associated with fear of violent crime, and differences between the levels of significance are marginal. This study is a first to examine whether murder may also be feared as a contemporaneous offense. The results are informative in identifying what drives fear of crime, particularly violent crime, for both men and women. Avenues for future research are discussed. © The Author(s) 2014.

Blockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure.

PubMed

Pickens, Charles L; Theberge, Florence R

2014-02-01

We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fear conditioning, suggesting that fear is suppressed. Here, we investigate the potential role of CB1 receptor activation by endocannabinoids in this fear suppression. We subjected rats to 10 days of fear conditioning and then administered systemic injections of the CB1 receptor antagonist SR141716 before a conditioned fear test was conducted 2 days later under extinction conditions. A second test was conducted without any injections on the following day (3 days after training) to examine retention of fear extinction. SR141716 injections did not increase fear expression 2 days after extended fear conditioning or affect within-session extinction; however, it impaired retention of between-session fear extinction in the day 3 test. These data suggest that CB1 receptor activation does not suppress fear soon after extended fear conditioning in the fear incubation task. The data also add to the existing literature on the role of CB1 receptors in extinction of conditioned fear.

Blockade of CB1 receptors prevents retention of extinction but does not increase low pre-incubated conditioned fear in the fear incubation procedure

PubMed Central

Pickens, Charles L.; Theberge, Florence R.

2015-01-01

We recently developed a procedure to study fear incubation in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fear conditioning, suggesting that fear is suppressed. Here, we investigate the potential role of CB1 receptor activation by endocannabinoids in this fear suppression. We gave rats 10 days of fear conditioning and then gave systemic injections of the CB1 receptor antagonist SR141716 before a conditioned fear test conducted 2 days later under extinction conditions. A second test was conducted without any injections on the following day (3 days post-training) to examine fear extinction retention. SR141716 injections did not increase fear expression 2 days after extended fear conditioning or affect within-session extinction, but impaired retention of between-session fear extinction in the day 3 test. These data suggest that CB1 receptor activation is not suppressing fear soon after extended fear conditioning in the fear incubation task. The data also add to an existing literature on the effects of CB1 receptors in extinction of conditioned fear. PMID:24346290

A crisis of visibility: The psychological consequences of false-positive screening mammograms, an interview study.

PubMed

Bond, Mary; Garside, Ruth; Hyde, Christopher

2015-11-01

To understand the meaning of having a false-positive screening mammogram. Qualitative interview study. Twenty-one women, who had experienced false-positive screening mammograms, took part in semi-structured interviews that were analysed with Interpretive Phenomenological Analysis. This research took place in the United Kingdom. The analysis revealed a wide range of response to having a false-positive mammogram, from nonchalance to extreme fear. These reactions come from the potential for the belief that one is healthy to be challenged by being recalled, as the worst is frequently assumed. For most, the image of the lesion on the X-ray brought the reality of this challenge into sharp focus, as they might soon discover they had breast cancer. Waiting, whether for the appointment, at the clinic or for biopsy results was considered the worst aspect of being recalled. Generally, the uncertainty was quickly resolved with the pronouncement of the 'all-clear', which brought considerable relief and the restoration of belief in the healthy self. However, for some, lack of information, contradictory information, or poor interpersonal communication meant that uncertainty about their health status lingered at least until their next normal screening mammogram. Mammography screening related anxiety lasted for up to 12 years. Breast cancer screening produces a 'crisis of visibility'. Accepting the screening invitation is taking a risk that you may experience unnecessary stress, uncertainty, fear, anxiety, and physical pain. Not accepting the invitation is taking a risk that malignant disease will remain invisible. Statement of contribution What is already known on this subject? More than 50,000 women a year in England have a false-positive mammogram (FPM). Having an FPM can cause anxiety compared with a normal mammogram. The anxiety can last up to 35 months. What does this study add? Refocuses attention from the average response found in quantitative studies to the wide range of individual response. Gives insight into the nature of the anxiety of having FPMs. Highlights the role of uncertainty in provoking distress from an FPM. © 2015 The British Psychological Society.

3. View from former light tower to Cape Elizabeth Light ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. View from former light tower to Cape Elizabeth Light Tower, view northeast, southwest side of Cape Elizabeth Tower - Cape Elizabeth Light Station, Near Two Lights State Park at end of Two Lights Road, off State Highway 77, Cape Elizabeth, Cumberland County, ME

Discrete emotion-congruent false memories in the DRM paradigm.

PubMed

Bland, Cassandra E; Howe, Mark L; Knott, Lauren

2016-08-01

Research has shown that false-memory production is enhanced for material that is emotionally congruent with the mood of the participant at the time of encoding. So far this research has only been conducted to examine the influence of generic negative affective mood states and generic negative stimuli on false-memory production. In addition, much of the research is limited as it focuses on valence and arousal dimensions, and fails to take into account the more comprehensive nature of emotions. The current study demonstrates that this effect goes beyond general negative or positive moods and acts at a more discrete emotional level. Participants underwent a standard emotion-induction procedure before listening to negative emotional or neutral associative word lists. The emotions induced, negative word lists, and associated nonpresented critical lures, were related to either fear or anger, 2 negative valence emotions that are also both high in arousal. Results showed that when valence and arousal are controlled for, false memories are more likely to be produced for discrete emotionally congruent compared with incongruent materials. These results support spreading activation theories of false remembering and add to our understanding of the adaptive nature of false-memory production. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Rare earth mineral potential in the southeastern U.S. Coastal Plain from integrated geophysical, geochemical, and geological approaches

USGS Publications Warehouse

Shah, Anjana K.; Bern, Carleton R.; Van Gosen, Bradley S.; Daniels, David L.; Benzel, William M.; Budahn, James R.; Ellefsen, Karl J.; Karst, Adam; Davis, Richard

2017-01-01

We combined geophysical, geochemical, mineralogical, and geological data to evaluate the regional presence of rare earth element (REE)−bearing minerals in heavy mineral sand deposits of the southeastern U.S. Coastal Plain. We also analyzed regional differences in these data to determine probable sedimentary provenance. Analyses of heavy mineral separates covering the region show strong correlations between thorium, monazite, and xenotime, suggesting that radiometric equivalent thorium (eTh) can be used as a geophysical proxy for those REE-bearing minerals. Airborne radiometric data collected during the National Uranium Resource Evaluation (NURE) program cover the southeastern United States with line spacing varying from ∼2 to 10 km. These data show eTh highs over Cretaceous and Tertiary Coastal Plain sediments from the Cape Fear arch in North Carolina to eastern Alabama; these highs decrease with distance from the Piedmont. Quaternary sediments along the modern coasts show weaker eTh anomalies, except near coast-parallel ridges from South Carolina to northern Florida. Prominent eTh anomalies are also observed over large riverbeds and their floodplains, even north of the Cape Fear arch where surrounding areas are relatively low. These variations were verified using ground geophysical measurements and sample analyses, indicating that radiometric methods are a useful exploration tool at varying scales. Further analyses of heavy mineral separates showed regional differences, not only in concentrations of monazite, but also of rutile and staurolite, and in magnetic susceptibility. The combined properties suggest the presence of subregions where heavy mineral sediments are primarily sourced from high-grade metamorphic, low-grade metamorphic, or igneous terrains, or where they represent a mixing of these sources. Comparisons between interpreted sources of heavy mineral sands near the Fall Line and igneous and metamorphic Piedmont and Blue Ridge units showed a strong correspondence with rocks closest to the Fall Line and poor correspondence with rocks farther inland. This strongly suggests that the primary source of those heavy minerals, especially monazite, is the rocks that formed the rocky coast that was present during opening of the Atlantic Ocean, which in turn indicates the importance of coastal processes in forming heavy mineral sand concentrations. Furthermore, narrow radiometric eTh and K anomalies are associated with major rivers, indicating limited spatial influence of fluvial processes. Later coastal plain sediment deposition appears to have involved reworking of sediments, providing an “inheritance” of the rocky coast composition that persists for some distance from the Fall Line. However, this inheritance is reduced with distance, and sediments within ∼100 km of the coast in Georgia and Florida exhibit properties indicative of mixing from multiple sources.

Fear of water in children and adults: etiology and familial effects.

PubMed

Graham, J; Gaffan, E A

1997-02-01

Water-fearful children (non-swimmers. 5-8 yrs and adults (non-swimmers or late learners, 23-73 yr) were compared with non-fearful controls of similar swimming ability. Parallel assessments were carried out with children and adults to investigate water-related experiences, water fear and competence in parents and siblings, and the relationship of water fear to other fear dimensions. Children were assessed behaviorally and by self and mother's report, adults by self-report. In neither children nor adults was there clear evidence that fearful and non-fearful groups differed in incidence of aversive water-related experience before fear onset. Parents usually believed that children's fear was present at first contact. In both samples, we found parent-offspring and sibling resemblances in fear. Analysis of details of children's contact with parents suggested that social learning within the family decreased water fear rather than increasing it; when both child and parent showed fear, that was as likely to reflect genetic influences as modeling. Young children's water fear forms part of a generic cluster, fear of the Unknown or Danger, while in adults it becomes independent of generic fears.

Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway.

PubMed

Pramanik, Kartick C; Kudugunti, Shashi K; Fofaria, Neel M; Moridani, Majid Y; Srivastava, Sanjay K

2013-09-01

Melanoma is highly metastatic and resistant to chemotherapeutic drugs. Our previous studies have demonstrated that caffeic acid phenethyl ester (CAPE) suppresses the growth of melanoma cells and induces reactive oxygen species generation. However, the exact mechanism of the growth suppressive effects of CAPE was not clear. Here, we determined the potential mechanism of CAPE against melanoma in vivo and in vitro. Administration of 10 mg/kg/day CAPE substantially suppressed the growth of B16F0 tumor xenografts in C57BL/6 mice. Tumors from CAPE-treated mice showed reduced phosphorylation of phosphoinositide 3-kinase, AKT, mammalian target of rapamycin and protein level of X-linked inhibitor of apoptosis protein (XIAP) and enhanced the cleavage of caspase-3 and poly (ADP ribose) polymerase. In order to confirm the in vivo observations, melanoma cells were treated with CAPE. CAPE treatment suppressed the activating phosphorylation of phosphoinositide 3-kinase at Tyr 458, phosphoinositide-dependent kinase-1 at Ser 241, mammalian target of rapamycin at Ser 2448 and AKT at Ser 473 in B16F0 and SK-MEL-28 cells in a concentration and time-dependent study. Furthermore, the expression of XIAP, survivin and BCL-2 was downregulated by CAPE treatment in both cell lines. Significant apoptosis was observed by CAPE treatment as indicated by cleavage of caspase-3 and poly (ADP ribose) polymerase. AKT kinase activity was inhibited by CAPE in a concentration-dependent manner. CAPE treatment increased the nuclear translocation of XIAP, indicating increased apoptosis in melanoma cells. To confirm the involvement of reactive oxygen species in the inhibition of AKT/XIAP pathway, cells were treated with antioxidant N-acetyl-cysteine (NAC) prior to CAPE treatment. Our results indicate that NAC blocked CAPE-mediated AKT/XIAP inhibition and protected the cells from apoptosis. Because AKT regulates XIAP, their interaction was examined by immunoprecipitation studies. Our results show that CAPE treatment decreased the interaction of AKT with XIAP. To establish the involvement of AKT in the apoptosis-inducing effects of CAPE, cells were transfected with AKT. Our results revealed that AKT overexpression attenuated the decrease in XIAP and significantly blocked CAPE-mediated apoptosis. Similarly, overexpression of XIAP further decreased CAPE-induced apoptosis. Taken together, our results suggest that CAPE suppresses phosphoinositide 3-kinase/AKT/XIAP pathway leading to apoptosis in melanoma tumor cells in vitro and in vivo.

Is panic disorder a disorder of physical fitness? A heuristic proposal.

PubMed

Perna, Giampaolo; Caldirola, Daniela

2018-01-01

Currently, panic disorder (PD) is considered a mental disorder based on the assumptions that panic attacks (PAs) are "false alarms" that arise from abnormally sensitive defense systems in the central nervous system and that PD is treated with therapies specifically acting on anxiety or fear mechanisms. This article aims to propose an alternative perspective based on the results of some experimental studies. Our heuristic proposal suggests not only that PD may be a mental disorder but also that patients with PD have real abnormal body functioning, mainly involving cardiorespiratory and balance systems, leading to a decline in global physical fitness. PAs, as well as physical symptoms or discomfort in some environmental situations, may be "real alarms" signaling that the adaptability resources of an organism are insufficient to respond appropriately to some internal or external changes, thus representing the transient conscious awareness of an imbalance in body functioning. The antipanic properties of several modern treatments for PD may include their beneficial effects on body functions. Although anxiety or fear mechanisms are evidently involved in PD, we hypothesize that a reduction of physical fitness is the "primum movens" of PD, while anxiety or fear is induced and sustained by repeated signals of impaired body functioning. We propose considering panic in a broader perspective that offers a central role to the body and to contemplate the possible role of somatic treatments in PD.

Is panic disorder a disorder of physical fitness? A heuristic proposal

PubMed Central

Perna, Giampaolo; Caldirola, Daniela

2018-01-01

Currently, panic disorder (PD) is considered a mental disorder based on the assumptions that panic attacks (PAs) are “false alarms” that arise from abnormally sensitive defense systems in the central nervous system and that PD is treated with therapies specifically acting on anxiety or fear mechanisms. This article aims to propose an alternative perspective based on the results of some experimental studies. Our heuristic proposal suggests not only that PD may be a mental disorder but also that patients with PD have real abnormal body functioning, mainly involving cardiorespiratory and balance systems, leading to a decline in global physical fitness. PAs, as well as physical symptoms or discomfort in some environmental situations, may be “real alarms” signaling that the adaptability resources of an organism are insufficient to respond appropriately to some internal or external changes, thus representing the transient conscious awareness of an imbalance in body functioning. The antipanic properties of several modern treatments for PD may include their beneficial effects on body functions. Although anxiety or fear mechanisms are evidently involved in PD, we hypothesize that a reduction of physical fitness is the “primum movens” of PD, while anxiety or fear is induced and sustained by repeated signals of impaired body functioning. We propose considering panic in a broader perspective that offers a central role to the body and to contemplate the possible role of somatic treatments in PD. PMID:29623195

Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1α

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Hyung Gyun; Han, Eun Hee; Im, Ji Hye

2015-09-25

Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. Moreover, CAPE inhibited 3-MC-induced CYP1A1 activity, mRNA expression, protein level, and promoter activity. CAPE treatment also decreased 3-MC-inducible xenobiotic-response element (XRE)-linked luciferase, aryl hydrocarbons receptor (AhR) transactivation and nuclear localization. CAPE induced hypoxia inducible factor-1α (HIF-1α) protein level and HIF-1α responsible element (HRE) transcriptional activity. CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 protein expression. Takenmore » together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1α induction. - Highlights: • CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. • CAPE inhibited 3-MC-induced CYP1A1 expression. • CAPE induced HIF-1α induction. • CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 expression.« less

75 FR 81637 - Commercial Lease for the Cape Wind Energy Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... Commercial Lease for the Cape Wind Energy Project AGENCY: Bureau of Ocean Energy Management, Regulation and... Renewable Energy Development on the Outer Continental Shelf (``OCS'') for the Cape Wind Energy Project... requirements of 30 CFR 285.231. The Lease is for the Cape Wind Energy Project (``Project'') which grants Cape...

Prospects for biological control of Cape-ivy with the Cape-ivy fly and the cape-ivy moth

USDA-ARS?s Scientific Manuscript database

Cape-ivy (Delairea odorata, Asteraceae), native to coastal floodplains and mountain riparian zones in eastern South Africa, is an invasive vine in coastal riparian, woodland and scrub habitats in California and southern Oregon. Cape-ivy smothers native vegetation and may impair water flow in coastal...

Development of a laboratory model to assess fear and anxiety in cats.

PubMed

de Rivera, Christina; Ley, Jacqui; Milgram, Bill; Landsberg, Gary

2017-06-01

Objectives The objectives of this study were: (1) to develop a laboratory-based model to assess fear and anxiety in cats using the feline open-field test (OFT) and the feline human interaction test (HIT); and (2) to validate the model using diazepam, a known anxiolytic. Methods Laboratory-housed cats (n = 41) were first classified as fearful, mildly fearful or non-fearful by a technician familiar with the cats and also by veterinary behaviorists (GL, JL), by assessing the cats' behavior in their home rooms. In experiment 1, each cat's behavior was assessed in an OFT and an HIT. In experiment 2, after administration of the anxiolytic diazepam, a subset of the cats was re-tested. Results In experiment 1, the OFT revealed significant group effects on two measures: duration of inactivity, and vocalization. Fearful animals had significantly longer periods of inactivity than non-fearful animals. Non-fearful and mildly fearful cats vocalized more frequently than fearful cats. In the HIT, fearful cats travelled less than non-fearful and mildly fearful cats. Fearful and mildly fearful animals had significantly longer durations of inactivity, and non-fearful and mildly fearful cats had a significantly higher frequency of vocalization compared with fearful cats. In experiment 2, in the OFT, treatment with diazepam caused an increase in distance travelled, shorter durations of inactivity, and more frequent inactivity and vocalization. In the HIT, diazepam increased distance travelled and decreased duration of inactivity. Fearful cats spent significantly less time near the human compared with non-fearful cats, and this persisted under diazepam. Conclusions and relevance The feline OFT and feline HIT can be used jointly to assess the effects of medications or other therapies on fear and anxiety in the domestic cat.

Generalization of conditioned fear along a dimension of increasing fear intensity

PubMed Central

Dunsmoor, Joseph E.; Mitroff, Stephen R.; LaBar, Kevin S.

2009-01-01

The present study investigated the extent to which fear generalization in humans is determined by the amount of fear intensity in nonconditioned stimuli relative to a perceptually similar conditioned stimulus. Stimuli consisted of graded emotionally expressive faces of the same identity morphed between neutral and fearful endpoints. Two experimental groups underwent discriminative fear conditioning between a face stimulus of 55% fear intensity (conditioned stimulus, CS+), reinforced with an electric shock, and a second stimulus that was unreinforced (CS−). In Experiment 1 the CS− was a relatively neutral face stimulus, while in Experiment 2 the CS− was the most fear-intense stimulus. Before and following fear conditioning, skin conductance responses (SCR) were recorded to different morph values along the neutral-to-fear dimension. Both experimental groups showed gradients of generalization following fear conditioning that increased with the fear intensity of the stimulus. In Experiment 1 a peak shift in SCRs extended to the most fear-intense stimulus. In contrast, generalization to the most fear-intense stimulus was reduced in Experiment 2, suggesting that discriminative fear learning procedures can attenuate fear generalization. Together, the findings indicate that fear generalization is broadly tuned and sensitive to the amount of fear intensity in nonconditioned stimuli, but that fear generalization can come under stimulus control. These results reveal a novel form of fear generalization in humans that is not merely based on physical similarity to a conditioned exemplar, and may have implications for understanding generalization processes in anxiety disorders characterized by heightened sensitivity to nonthreatening stimuli. PMID:19553384

Specific and social fears in children and adolescents: separating normative fears from problem indicators and phobias.

PubMed

Laporte, Paola P; Pan, Pedro M; Hoffmann, Mauricio S; Wakschlag, Lauren S; Rohde, Luis A; Miguel, Euripedes C; Pine, Daniel S; Manfro, Gisele G; Salum, Giovanni A

2017-01-01

To distinguish normative fears from problematic fears and phobias. We investigated 2,512 children and adolescents from a large community school-based study, the High Risk Study for Psychiatric Disorders. Parent reports of 18 fears and psychiatric diagnosis were investigated. We used two analytical approaches: confirmatory factor analysis (CFA)/item response theory (IRT) and nonparametric receiver operating characteristic (ROC) curve. According to IRT and ROC analyses, social fears are more likely to indicate problems and phobias than specific fears. Most specific fears were normative when mild; all specific fears indicate problems when pervasive. In addition, the situational fear of toilets and people who look unusual were highly indicative of specific phobia. Among social fears, those not restricted to performance and fear of writing in front of others indicate problems when mild. All social fears indicate problems and are highly indicative of social phobia when pervasive. These preliminary findings provide guidance for clinicians and researchers to determine the boundaries that separate normative fears from problem indicators in children and adolescents, and indicate a differential severity threshold for specific and social fears.

Protective Effect of Combined Caffeic Acid Phenethyl Ester and Bevacizumab Against Hydrogen Peroxide-Induced Oxidative Stress in Human RPE Cells.

PubMed

Dinc, Erdem; Ayaz, Lokman; Kurt, Akif Hakan

2017-12-01

This study aimed to evaluate the protective effects of caffeic acid phenethyl ester (CAPE) and combined CAPE-bevacizumab against oxidative stress induced by hydrogen peroxide (H 2 O 2 ) in human retinal pigment epithelium. ARPE-19 cells were pretreated with 5, 10, and 30 μM CAPE alone and in combination with bevacizumab for 3 h, then exposed to H 2 O 2 for 16 h. Cell viability was evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Vascular endothelial growth factor (VEGF) protein levels in the medium were measured using a human VEGF ELISA kit. Total antioxidant status (TAS) and total oxidant status (TOS) were measured in ARPE-19 cells using the test kit from Rel Assay. Expression levels of VEGF, Bax, Bcl-2, cytochrome c, apoptotic protease activating factor-1 (apaf-1), and caspase-3 were determined using reverse transcription polymerase chain reaction. Pretreatment of ARPE-19 cells with 30 μM CAPE and combined CAPE-bevacizumab reduced H 2 O 2 mediated cell death. H 2 O 2 -induced oxidative stress increased TOS and VEGF production, which was significantly inhibited by CAPE and the CAPE-bevacizumab combination. VEGF, Bax, cytochrome c, apaf-1, and caspase-3 gene expressions were significantly decreased in cells pretreated with 5, 10, and 30 μM CAPE and combined CAPE-bevacizumab compared to the H 2 O 2 group. In addition, Bcl-2 expression was significantly increased in both the CAPE and CAPE-bevacizumab combination groups compared to the H 2 O 2 group. CAPE has a protective effect on ARPE-19 cells against oxidative stress, and VEGF protein level and expression can be decreased by incubation with different concentrations of CAPE. These results demonstrate that CAPE suppresses the mitochondria-mediated apoptosis in ARPE-19 cells under oxidative stress. In addition, the use of CAPE in combination with bevacizumab has an additive effect.

The influence of animal fear on attentional capture by fear-relevant animal stimuli in children.

PubMed

Waters, Allison M; Lipp, Ottmar V

2008-01-01

The present study demonstrated that pictures of fear-relevant animals, snakes and spiders, presented among backgrounds of other animal stimuli captured attention and interfered in the detection of a neutral target to the same extent in a large sample of unselected children (N=81). Moreover, detection of a neutral target animal was slowed more in the presence of a feared fear-relevant distracter, e.g., a snake for snake fearful children, than in the presence of a not feared fear-relevant distracter, e.g., a spider for snake fearful children. These results indicate attentional capture by phylogenetically fear-relevant animal stimuli in children and the selective enhancement of this effect by fear of these animals. These findings are consistent with current models of preferential processing of phylogenetically prepared threat stimuli and with cognitive models of anxiety that propose an enhancing effect of fear in the processing of fear-related stimuli.

Neural response patterns in spider, blood-injection-injury and social fearful individuals: new insights from a simultaneous EEG/ECG-fMRI study.

PubMed

Michałowski, Jarosław M; Matuszewski, Jacek; Droździel, Dawid; Koziejowski, Wojciech; Rynkiewicz, Andrzej; Jednoróg, Katarzyna; Marchewka, Artur

2017-06-01

In the present simultaneous EEG/ECG-fMRI study we compared the temporal and spatial characteristics of the brain responses and the cardiac activity during fear picture processing between spider, blood-injection-injury (BII) and social fearful as well as healthy (non-fearful) volunteers. All participants were presented with two neutral and six fear-related blocks of pictures: two social, two spider and two blood/injection fear blocks. In a social fear block neutral images were occasionally interspersed with photographs of angry faces and social exposure scenes. In spider and blood/injection fear blocks neutral pictures were interspersed with spider fear-relevant and blood/injection pictures, respectively. When compared to healthy controls the social fear group responded with increased activations in the anterior orbital, middle/anterior cingulate and middle/superior temporal areas for pictures depicting angry faces and with a few elevated superior frontal activations for social exposure scenes. In the blood/injection fear group, heart rate was decreased and the activity in the middle/inferior frontal and visual processing regions was increased for blood/injection pictures. The HR decrease for blood/injection pictures correlated with increased frontal responses. In the spider fear group, spider fear-relevant pictures triggered increased activations within a broad subcortical and cortical neural fear network. The HR response for spider fear-relevant stimuli was increased and correlated with an increased insula and hippocampus activity. When compared to healthy controls, all fear groups showed higher LPP amplitudes for their feared cues and an overall greater P1 hypervigilance effect. Contrasts against the fear control groups showed that the increased responses for fear-specific stimuli are mostly related to specific fears and not to general anxiety proneness. The results suggest different engagement of cognitive evaluation and down-regulation strategies and an overall increased sensitization of the fear system in the three fear groups.

76 FR 40725 - Approval of Outer Continental Shelf (OCS) Permit Issued to Cape Wind Associates, LLC (EPA Permit...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... Cape Wind Associates, LLC (Cape Wind). The OCS permit, which was issued pursuant to regulations, authorizes Cape Wind to construct and operate an offshore renewable wind energy project in federal waters off... Issued to Cape Wind Associates, LLC (EPA Permit Number OCS-R1-01) AGENCY: Environmental Protection Agency...

Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors.

PubMed

Bijlsma, Elisabeth Y; Hendriksen, Hendrikus; Baas, Johanna M P; Millan, Mark J; Groenink, Lucianne

2015-10-01

The inability to associate aversive events with relevant cues (i.e. fear learning) may lead to maladaptive anxiety. To further study the role of the serotonin transporter (SERT) in fear learning, classical fear conditioning was studied in SERT knockout rats (SERT(-/-)) using fear potentiation of the startle reflex. Next, fear acquisition and concomitant development of contextual conditioned fear were monitored during training. To differentiate between developmental and direct effects of reduced SERT functioning, effects of acute and chronic SSRI treatment were studied in adult rats. Considering the known interactions between serotonin and corticotropin-releasing factor (CRF), we studied the effect of the CRFR1 antagonist CP154,526 on behavioral changes observed and determined CRF1 receptor levels in SERT(-/-) rats. SERT(-/-) showed blunted fear potentiation and enhanced contextual fear, which resulted from a deficit in fear acquisition. Paroxetine treatment did not affect acquisition or expression of fear-potentiated startle, suggesting that disturbed fear learning in SERT(-/-) results from developmental changes and not from reduced SERT functioning. Although CRF1 receptor levels did not differ significantly between genotypes, CP154,526 treatment normalized both cue- and contextual fear in SERT(-/-) during acquisition, but not expression of fear-potentiated startle. The disrupted fear acquisition and concomitant increase in contextual conditioned fear-potentiated startle fear in SERT(-/-) resembles the associative learning deficit seen in patients with panic disorder and suggests that normal SERT functioning is crucial for the development of an adequate fear neuro-circuitry. Moreover, the normalization of fear acquisition by CP154,526 suggests a role for central CRF signaling in the generalization of fear. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

Alter spontaneous activity in amygdala and vmPFC during fear consolidation following 24 h sleep deprivation.

PubMed

Feng, Pan; Becker, Benjamin; Feng, Tingyong; Zheng, Yong

2018-05-15

Sleep deprivation (SD) has been associated with cognitive and emotional disruptions, however its impact on the acquisition of fear and subsequent fear memory consolidation remain unknown. To address this question, we measured human brain activity before and after fear acquisition under conditions of 24 h sleep deprivation versus normal sleep using resting-state functional magnetic resonance imaging (rs-fMRI). Additionally, we explored whether the fear acquisition-induced change of brain activity during the fear memory consolidation window can be predicted by subjective fear ratings and autonomic fear response, assessed by skin conductance responses (SCR) during acquisition. Behaviorally, the SD group demonstrated increased subjective and autonomic fear responses compared to controls at the stage of fear acquisition. During the stage of fear consolidation, the SD group displayed decreased ventromedial prefrontal cortex (vmPFC) activity and concomitantly increased amygdala activity. Moreover, in the SD group fear acquisition-induced brain activity changes in amygdala were positively correlated with both, subjective and autonomic fear indices during acquisition, whereas in controls changes vmPFC activity were positively correlated with fear indices during acquisition. Together, the present findings suggested that SD may weaken the top-down ability of the vmPFC to regulate amygdala activity during fear memory consolidation. Moreover, subjective and objective fear at fear acquisition stage can predict the change of brain activity in amygdala in fear memory consolidation following SD. Copyright © 2018 Elsevier Inc. All rights reserved.

Extinction during reconsolidation eliminates recovery of fear conditioned to fear-irrelevant and fear-relevant stimuli.

PubMed

Thompson, Alina; Lipp, Ottmar V

2017-05-01

Extant literature suggests that extinction training delivered during the memory reconsolidation period is superior to traditional extinction training in the reduction of fear recovery, as it targets the original fear memory trace. At present it is debated whether different types of fear memories are differentially sensitive to behavioral manipulations of reconsolidation. Here, we examined post-reconsolidation recovery of fear as a function of conditioned stimulus (CS) fear-relevance, using the unconditioned stimulus (US) to reactivate and destabilize conditioned fear memories. Participants (N = 56; 25 male; M = 24.39 years, SD = 7.71) in the US-reactivation and control group underwent differential fear conditioning to fear-relevant (spiders/snakes) and fear-irrelevant (geometric shapes) CSs on Day 1. On Day 2, participants received either reminded (US-reactivation) or non-reminded extinction training. Tests of fear recovery, conducted 24 h later, revealed recovery of differential electrodermal responding to both classes of CSs in the control group, but not in the US-reactivation group. These findings indicate that the US reactivation-extinction procedure eliminated recovery of extinguished responding not only to fear-irrelevant, but also to fear-relevant CSs. Contrasting previous reports, our findings show that post-reconsolidation recovery of conditioned responding is not a function of CS fear-relevance and that persistent reduction of fear, conditioned to fear-relevant CSs, can be achieved through behavioral manipulations of reconsolidation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Nothing to Fear but Fear Itself? Fear of Fear, Fear of Greed and Gender Effects in Two-Person Asymmetric Social Dilemmas

ERIC Educational Resources Information Center

Kuwabara, Ko

2005-01-01

This article extends Simpson's (2003) research on sex differences in social dilemmas. To test the hypotheses that men defect in response to greed and women to fear, Simpson created Fear and Greed Dilemmas, but experiments using these games supported the greed hypothesis only. In this article I focus on why the fear hypothesis failed and suggest…

Conditioned Fear Acquisition and Generalization in Generalized Anxiety Disorder.

PubMed

Tinoco-González, Daniella; Fullana, Miquel Angel; Torrents-Rodas, David; Bonillo, Albert; Vervliet, Bram; Blasco, María Jesús; Farré, Magí; Torrubia, Rafael

2015-09-01

Abnormal fear conditioning processes (including fear acquisition and conditioned fear-generalization) have been implicated in the pathogenesis of anxiety disorders. Previous research has shown that individuals with panic disorder present enhanced conditioned fear-generalization in comparison to healthy controls. Enhanced conditioned fear-generalization could also characterize generalized anxiety disorder (GAD), but research so far is inconclusive. An important confounding factor in previous research is comorbidity. The present study examined conditioned fear-acquisition and fear-generalization in 28 patients with GAD and 30 healthy controls using a recently developed fear acquisition and generalization paradigm assessing fear-potentiated startle and online expectancies of the unconditioned stimulus. Analyses focused on GAD patients without comorbidity but included also patients with comorbid anxiety disorders. Patients and controls did not differ as regards fear acquisition. However, contrary to our hypothesis, both groups did not differ either in most indexes of conditioned fear-generalization. Moreover, dimensional measures of GAD symptoms were not correlated with conditioned fear-generalization indexes. Comorbidity did not have a significant impact on the results. Our data suggest that conditioned fear-generalization is not enhanced in GAD. Results are discussed with special attention to the possible effects of comorbidity on fear learning abnormalities. Copyright © 2014. Published by Elsevier Ltd.

Learning to fear a second-order stimulus following vicarious learning.

PubMed

Reynolds, Gemma; Field, Andy P; Askew, Chris

2017-04-01

Vicarious fear learning refers to the acquisition of fear via observation of the fearful responses of others. The present study aims to extend current knowledge by exploring whether second-order vicarious fear learning can be demonstrated in children. That is, whether vicariously learnt fear responses for one stimulus can be elicited in a second stimulus associated with that initial stimulus. Results demonstrated that children's (5-11 years) fear responses for marsupials and caterpillars increased when they were seen with fearful faces compared to no faces. Additionally, the results indicated a second-order effect in which fear-related learning occurred for other animals seen together with the fear-paired animal, even though the animals were never observed with fearful faces themselves. Overall, the findings indicate that for children in this age group vicariously learnt fear-related responses for one stimulus can subsequently be observed for a second stimulus without it being experienced in a fear-related vicarious learning event. These findings may help to explain why some individuals do not recall involvement of a traumatic learning episode in the development of their fear of a specific stimulus.

Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway

PubMed Central

Srivastava, Sanjay K.

2013-01-01

Melanoma is highly metastatic and resistant to chemotherapeutic drugs. Our previous studies have demonstrated that caffeic acid phenethyl ester (CAPE) suppresses the growth of melanoma cells and induces reactive oxygen species generation. However, the exact mechanism of the growth suppressive effects of CAPE was not clear. Here, we determined the potential mechanism of CAPE against melanoma in vivo and in vitro. Administration of 10 mg/kg/day CAPE substantially suppressed the growth of B16F0 tumor xenografts in C57BL/6 mice. Tumors from CAPE-treated mice showed reduced phosphorylation of phosphoinositide 3-kinase, AKT, mammalian target of rapamycin and protein level of X-linked inhibitor of apoptosis protein (XIAP) and enhanced the cleavage of caspase-3 and poly (ADP ribose) polymerase. In order to confirm the in vivo observations, melanoma cells were treated with CAPE. CAPE treatment suppressed the activating phosphorylation of phosphoinositide 3-kinase at Tyr 458, phosphoinositide-dependent kinase-1 at Ser 241, mammalian target of rapamycin at Ser 2448 and AKT at Ser 473 in B16F0 and SK-MEL-28 cells in a concentration and time-dependent study. Furthermore, the expression of XIAP, survivin and BCL-2 was downregulated by CAPE treatment in both cell lines. Significant apoptosis was observed by CAPE treatment as indicated by cleavage of caspase-3 and poly (ADP ribose) polymerase. AKT kinase activity was inhibited by CAPE in a concentration-dependent manner. CAPE treatment increased the nuclear translocation of XIAP, indicating increased apoptosis in melanoma cells. To confirm the involvement of reactive oxygen species in the inhibition of AKT/XIAP pathway, cells were treated with antioxidant N-acetyl-cysteine (NAC) prior to CAPE treatment. Our results indicate that NAC blocked CAPE-mediated AKT/XIAP inhibition and protected the cells from apoptosis. Because AKT regulates XIAP, their interaction was examined by immunoprecipitation studies. Our results show that CAPE treatment decreased the interaction of AKT with XIAP. To establish the involvement of AKT in the apoptosis-inducing effects of CAPE, cells were transfected with AKT. Our results revealed that AKT overexpression attenuated the decrease in XIAP and significantly blocked CAPE-mediated apoptosis. Similarly, overexpression of XIAP further decreased CAPE-induced apoptosis. Taken together, our results suggest that CAPE suppresses phosphoinositide 3-kinase/AKT/XIAP pathway leading to apoptosis in melanoma tumor cells in vitro and in vivo. PMID:23640046

Center for the Advancement of Pharmacy Education 2013 Educational Outcomes

PubMed Central

Medina, Melissa S.; Stowe, Cindy D.; Robinson, Evan T.; DeLander, Gary; Beck, Diane E.; Melchert, Russell B.; Supernaw, Robert B.; Roche, Victoria F.; Gleason, Brenda L.; Strong, Mark N.; Bain, Amanda; Meyer, Gerald E.; Dong, Betty J.; Rochon, Jeffrey; Johnston, Patty

2013-01-01

An initiative of the Center for the Advancement of Pharmacy Education (formerly the Center for the Advancement of Pharmaceutical Education) (CAPE), the CAPE Educational Outcomes are intended to be the target toward which the evolving pharmacy curriculum should be aimed. Their development was guided by an advisory panel composed of educators and practitioners nominated for participation by practitioner organizations. CAPE 2013 represents the fourth iteration of the Educational Outcomes, preceded by CAPE 1992, CAPE 1998 and CAPE 2004 respectively. The CAPE 2013 Educational Outcomes were released at the AACP July 2013 Annual meeting and have been revised to include 4 broad domains, 15 subdomains, and example learning objectives. PMID:24159203

Comparison of children's fears of medical experiences across two cultures.

PubMed

Mahat, Ganga; Scoloveno, Mary Ann; Cannella, Barbara

2004-01-01

This study examined the self-reported fears of school-age children living in the United States and in Nepal. Thirty school-age children from each country, matched by sex and age, participated in this study. The revised version of the Child Medical Fear Scale was used to identify medical fears of children. Among 17 feared items, the result showed getting a shot to be the most feared item reported by both groups. Nepalese children reported higher fear scores than did American children. It also was found that there was a significant difference in fear scores between Nepalese boys and girls, with girls reporting higher fear scores than boys. There was no difference in fear scores between American boys and girls. The findings of this study are important to nurse practitioners in understanding children's fears of medical experiences across different cultures. Nurses can support children in dealing with their fears of medical experiences by recognizing these fears and taking into consideration the child's family, sex, and culture when planning care. Nursing implications are discussed.

33 CFR 334.595 - Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape Canaveral Air Force Station, FL...

Code of Federal Regulations, 2014 CFR

2014-07-01

...; 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.595 Section 334.595.... The regulations in this section shall be enforced by the Commander, 45th Space Wing, Patrick Air Force... AND RESTRICTED AREA REGULATIONS § 334.595 Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape...

33 CFR 334.595 - Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape Canaveral Air Force Station, FL...

Code of Federal Regulations, 2013 CFR

2013-07-01

...; 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.595 Section 334.595.... The regulations in this section shall be enforced by the Commander, 45th Space Wing, Patrick Air Force... AND RESTRICTED AREA REGULATIONS § 334.595 Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape...

33 CFR 334.595 - Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape Canaveral Air Force Station, FL...

Code of Federal Regulations, 2012 CFR

2012-07-01

...; 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.595 Section 334.595.... The regulations in this section shall be enforced by the Commander, 45th Space Wing, Patrick Air Force... AND RESTRICTED AREA REGULATIONS § 334.595 Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape...

33 CFR 334.595 - Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape Canaveral Air Force Station, FL...

Code of Federal Regulations, 2010 CFR

2010-07-01

...; 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.595 Section 334.595.... The regulations in this section shall be enforced by the Commander, 45th Space Wing, Patrick Air Force... AND RESTRICTED AREA REGULATIONS § 334.595 Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape...

33 CFR 334.595 - Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape Canaveral Air Force Station, FL...

Code of Federal Regulations, 2011 CFR

2011-07-01

...; 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.595 Section 334.595.... The regulations in this section shall be enforced by the Commander, 45th Space Wing, Patrick Air Force... AND RESTRICTED AREA REGULATIONS § 334.595 Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape...

75 FR 22433 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... plans to Cape Crozier (ASPA 124), Cape Royds (ASPA 121), Cape Bird, and Beaufort Island (ASPA 105) to study penguins and the effect of age, experience and physiology on individual foraging efficiency and... Crozier (ASPA 124), Cape Royds (ASPA 121), Cape Bird, and Beaufort Island (ASPA 105). Dates: September 1...

Childhood dental fear in relation to parental child-rearing attitudes.

PubMed

ten Berge, M; Veerkamp, J S J; Hoogstraten, J; Prins, P J M

2003-02-01

The aim of this study was to assess the relation between parental self-reported child-rearing attitudes and dental fear in children. The parents of 51 children with high dental fear and of 56 children with low dental fear, of different age groups, completed the Amsterdam version of the Parental Attitude Research Instrument. In addition, parents were asked to rate their own dental fear. Multivariate analysis of variance (child fear x parental fear x child age) showed a significant main effect only of child dental fear on parental self-complaints (p = .03). For parental dental fear, main effects were found on overprotection and on promotion of autonomy (p < or = .01). No age effects were found. Also, no relation between children's dental fear and parental dental fear was found. Based on the present findings, it was concluded that parents may play a more secondary, mediating role in the etiological process of dental fear in children.

Evoked fear and effects of appeals on attitudes to performing breast self-examination: an information-processing perspective.

PubMed

Ruiter, R A; Kok, G; Verplanken, B; Brug, J

2001-06-01

The effect of fear arousal on attitude toward participating in early detection activities [i.e. breast self-examination (BSE)] was studied from an information-processing perspective. It was hypothesized that fear arousal motivates respondents to more argument-based processing of fear-relevant persuasive information. Respondents first read information about breast cancer in which fear was manipulated. After measuring fear arousal, respondents read a persuasive message about performing BSE. Analyses with reported fear, but not manipulated fear, found support for the hypothesis. Respondents who reported mild fear of breast cancer based their attitude toward BSE more on the arguments provided than respondents who reported low fear of breast cancer. This finding suggests that the use of fear arousal may be an efficient tool in health education practice. However, alternative interpretations are provided, in addition to the suggestion to be careful with using fear arousal in health education messages.

Fears about antiretroviral therapy among users of the internet forum for people living with HIV/AIDS in Russia.

PubMed

Dudina, Victoria I; Judina, Darja I; King, Elizabeth J

2017-02-01

The purpose of this research was to identify different types of fear related to starting and adhering to antiretroviral therapy (ART) among people living with HIV (PLHIV) in Russia. Data were collected from the Russian-language internet forum for PLHIV (hivlife.info). Qualitative data analysis focused on the sections of the forum where users discussed health-related issues in order to identify fears related to HIV treatment. The following types of fear were revealed: fear of the illness, fear to learn negative information about one's health, fear of side effects, fear of therapy to be ineffective, fear that the appropriate medications will become unavailable, fear of lifestyle changes, and fear for the well-being of significant others. Efforts to increase the uptake of and adherence to ART should take into account the fears of PLHIV.

Recognizing Student Fear: The Elephant in the Classroom

ERIC Educational Resources Information Center

Bledsoe, T. Scott; Baskin, Janice J.

2014-01-01

Understanding fear, its causes, and its impact on students can be important for educators who seek ways to help students manage their fears. This paper explores common types of student fears such as performance-based anxiety, fear of failure, fear of being laughed at, and cultural components of fear that impact learning. The cognitive, emotional,…

High fear of intra-oral injections: prevalence and relationship to dental fear and dental avoidance among 10- to 16-yr-old children.

PubMed

Berge, Karin G; Agdal, Maren L; Vika, Margrethe; Skeie, Marit S

2016-12-01

The present study aimed to: (i) estimate the prevalence of self-reported high fear of intra-oral injections, high blood-injury fear, and injection fear; (ii) explore the overlap between high fear of intra-oral injections and high fear of dental treatment; and (iii) evaluate the possible consequence of high fear of intra-oral injections in terms of avoidance of dental care. The sample included 1,441 subjects, 10- to 16-yr of age, attending elementary schools in a county of Norway. Data were collected using questionnaires that were completed in classrooms. The survey instruments used were the Intra-Oral Injection Fear-scale, the Children's Fear Survey Schedule-Dental Subscale, the Injection Phobia scale for children, and the Mutilation Questionnaire for children. In total, 13.9% of the children reported high intra-oral injection fear. A strong association was found between fear of intra-oral injections and dental fear. When an intra-oral injection was needed, 10.6% would avoid dental treatment. In multiple regression analysis, high intra-oral injection fear was found to be associated with avoidance of dental treatment (OR = 6.52; 95% CI: 3.99-10.67). It was concluded that high fear of intra-oral injections was prevalent and might lead to avoidance of necessary dental treatment. Hence, intra-oral injection fear should be addressed before treatment of dental fear. © 2016 Eur J Oral Sci.

A latent growth examination of fear development in infancy: contributions of maternal depression and the risk for toddler anxiety.

PubMed

Gartstein, Maria A; Bridgett, David J; Rothbart, Mary K; Robertson, Christopher; Iddins, Erin; Ramsay, Kristin; Schlect, Sarah

2010-05-01

Growth modeling was used to examine the developmental trajectory of infant temperamental fear with maternal fear and depressive symptoms as predictors of infant fearfulness and change in infant fear predicting toddler anxiety symptoms. In Study 1, a sample of 158 mothers reported their own depressive symptoms and fear when their children were 4 months of age and infant fearfulness at 4, 6, 8, 10, and 12 months. Maternal symptoms of depression predicted steeper increases in infant fearfulness over time (z = 2.06, p < .05), with high initial infant fear and steeper increases in fear (intercept, z = 2.32, p < .05, and slope, z = 1.88, p < .05) predicting more severe toddler anxiety symptoms. In Study 2, an independent sample of 134 mothers completed measures of maternal depression and fear when the infants were 4 months old, and standardized laboratory observations of infant fear were made at 8, 10, and 12 months. Consistent with Study 1, maternal depression accounted for change in fearfulness (z = 2.30, p < .05), with more frequent and more severe maternal symptoms leading to greater increases in infant fear and increases in fearfulness z = 2.08, p < .05) leading to more problematic toddler anxiety. The implications and contributions of these findings are discussed in terms of methodology, fear development, and developmental psychopathology. 2010 APA, all rights reserved

Resting-state functional connectivity between amygdala and the ventromedial prefrontal cortex following fear reminder predicts fear extinction

PubMed Central

Feng, Pan; Zheng, Yong

2016-01-01

Investigations of fear conditioning have elucidated the neural mechanisms of fear acquisition, consolidation and extinction, but it is not clear how the neural activation following fear reminder influence the following extinction. To address this question, we measured human brain activity following fear reminder using resting-state functional magnetic resonance imaging, and investigated whether the extinction effect can be predicted by resting-state functional connectivity (RSFC). Behaviorally, we found no significant differences of fear ratings between the reminder group and the no reminder group at the fear acquisition and extinction stages, but spontaneous recovery during re-extinction stage appeared only in the no reminder group. Imaging data showed that functional connectivity between ventromedial prefrontal cortex (vmPFC) and amygdala in the reminder group was greater than that in the no reminder group after fear memory reactivation. More importantly, the functional connectivity between amygdala and vmPFC of the reminder group after fear memory reactivation was positively correlated with extinction effect. These results suggest RSFC between amygdala and the vmPFC following fear reminder can predict fear extinction, which provide important insight into the neural mechanisms of fear memory after fear memory reactivation. PMID:27013104

Cape Cod Transit Task Force : Five-Year Public Transportation Plan

DOT National Transportation Integrated Search

2002-06-30

The U.S. Department of Transportation's Volpe National Transportation Systems : Center has been working in cooperation with the Cape Cod Regional Transit : Authority, the Cape Cod Commission, and other organizations participating on : the Cape Cod Tr...

Component fears of claustrophobia associated with mock magnetic resonance imaging.

PubMed

McGlynn, F Dudley; Smitherman, Todd A; Hammel, Jacinda C; Lazarte, Alejandro A

2007-01-01

A conceptualization of claustrophobia [Rachman, S., & Taylor, S. (1993). Analyses of claustrophobia. Journal of Anxiety Disorders, 7, 281-291] was evaluated in the context of magnetic resonance imaging. One hundred eleven students responded to questionnaires that quantified fear of suffocation, fear of restriction, and sensitivity to anxiety symptoms. Sixty-four of them were then exposed to a mock magnetic resonance imaging assessment; maximum subjective fear during the mock assessment was self-reported, behavioral reactions to the mock assessment were characterized, and heart rates before and during the assessment were recorded. Scores for fear of suffocation, fear of restriction, and anxiety sensitivity were used to predict subjective, behavioral, and cardiac fear. Subjective fear during the mock assessment was predicted by fears of suffocation and public anxiousness. Behavioral fear (escape/avoidance) was predicted by fears of restriction and suffocation, and sensitivity to symptoms related to suffocation. Cardiac fear was predicted by fear of public anxiousness. The criterion variance predicted was impressive, clearly sufficient to legitimize both the research preparation and the conceptualization of claustrophobia that was evaluated.

Opioid receptors regulate blocking and overexpectation of fear learning in conditioned suppression.

PubMed

Arico, Carolyn; McNally, Gavan P

2014-04-01

Endogenous opioids play an important role in prediction error during fear learning. However, the evidence for this role has been obtained almost exclusively using the species-specific defense response of freezing as the measure of learned fear. It is unknown whether opioid receptors regulate predictive fear learning when other measures of learned fear are used. Here, we used conditioned suppression as the measure of learned fear to assess the role of opioid receptors in fear learning. Experiment 1a studied associative blocking of fear learning. Rats in an experimental group received conditioned stimulus A (CSA) + training in Stage I and conditioned stimulus A and B (CSAB) + training in Stage II, whereas rats in a control group received only CSAB + training in Stage II. The prior fear conditioning of CSA blocked fear learning to conditioned stimulus B (CSB) in the experimental group. In Experiment 1b, naloxone (4 mg/kg) administered before Stage II prevented this blocking, thereby enabling normal fear learning to CSB. Experiment 2a studied overexpectation of fear. Rats received CSA + training and CSB + training in Stage I, and then rats in the experimental group received CSAB + training in Stage II whereas control rats did not. The Stage II compound training of CSAB reduced fear to CSA and CSB on test. In Experiment 2b, naloxone (4 mg/kg) administered before Stage II prevented this overexpectation. These results show that opioid receptors regulate Pavlovian fear learning, augmenting learning in response to positive prediction error and impairing learning in response to negative prediction error, when fear is assessed via conditioned suppression. These effects are identical to those observed when freezing is used as the measure of learned fear. These findings show that the role for opioid receptors in regulating fear learning extends across multiple measures of learned fear.

Cultural aspects of morbid fears in Qatari women.

PubMed

el-Islam, M F

1994-05-01

The contents of morbid fears are patterned by cultural factors that decide the nature of the objects of the fears. Common factors in Western cultures do not obtain in local culture, which provides other objects for morbid fears in predisposed individuals. In the muslim community in Qatar, after-death fears dominated panic attacks, agoraphobia was rare, social phobias mirrored shame rather than guilt about failure to fulfil socially accepted norms of social behaviour, and obsessional fears revolved around fears of failure to control devil-induced impulses to harm self or others. Hypochondriacal fears of disease thrived because somatically oriented physicians colluded with somatizing patients in an endless search for presumed organic aetiology. Generalized anxiety fears were not encountered independently of other morbid fears.

Incubation of conditioned fear in the conditioned suppression model in rats: role of food-restriction conditions, length of conditioned stimulus, and generality to conditioned freezing

PubMed Central

Pickens, Charles L.; Navarre, Brittany M.; Nair, Sunila G.

2010-01-01

We recently adapted the conditioned suppression of operant responding method to study fear incubation. We found that food-restricted rats show low fear 2 days after extended (10 d; 100 30-sec tone-shock pairings) fear training and high fear after 1–2 months. Here, we studied a potential mechanism of fear incubation: extended food-restriction stress. We also studied whether fear incubation is observed after fear training with a prolonged-duration (6-min) tone conditioned stimulus (CS), and whether conditioned freezing incubates after extended training in rats with or without a concurrent operant task. Conditioned fear was assessed 2 days and 1 month after training. In the conditioned suppression method, fear incubation was reliably observed in rats under moderate food-restriction conditions (18–20 g food/day) that allowed for weight gain, and after extended (10 d), but not limited (1 d), fear training with the 6-min CS. Incubation of conditioned freezing was observed after extended fear training in rats lever-pressing for food and, to a lesser degree, in rats not performing an operant task. Results indicate that prolonged hunger-related stress does not account for fear incubation in the conditioned suppression method, and that fear incubation occurs to a longer-duration (6-min) fear CS. Extended training also leads to robust fear incubation of conditioned freezing in rats performing an operant task and weaker fear incubation in rats not performing an operant task. PMID:20600654

Incubation of conditioned fear in the conditioned suppression model in rats: role of food-restriction conditions, length of conditioned stimulus, and generality to conditioned freezing.

PubMed

Pickens, C L; Navarre, B M; Nair, S G

2010-09-15

We recently adapted the conditioned suppression of operant responding method to study fear incubation. We found that food-restricted rats show low fear 2 days after extended (10 d; 100 30-s tone-shock pairings) fear training and high fear after 1-2 months. Here, we studied a potential mechanism of fear incubation: extended food-restriction stress. We also studied whether fear incubation is observed after fear training with a prolonged-duration (6-min) tone conditioned stimulus (CS), and whether conditioned freezing incubates after extended training in rats with or without a concurrent operant task. Conditioned fear was assessed 2 days and 1 month after training. In the conditioned suppression method, fear incubation was reliably observed in rats under moderate food-restriction conditions (18-20 g food/day) that allowed for weight gain, and after extended (10 d), but not limited (1 d), fear training with the 6-min CS. Incubation of conditioned freezing was observed after extended fear training in rats lever-pressing for food and, to a lesser degree, in rats not performing an operant task. Results indicate that prolonged hunger-related stress does not account for fear incubation in the conditioned suppression method, and that fear incubation occurs to a longer-duration (6-min) fear CS. Extended training also leads to robust fear incubation of conditioned freezing in rats performing an operant task and weaker fear incubation in rats not performing an operant task. (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

Spontaneous brain activity following fear reminder of fear conditioning by using resting-state functional MRI

PubMed Central

Feng, Pan; Zheng, Yong; Feng, Tingyong

2015-01-01

Although disrupting reconsolidation may be a promising approach to attenuate or erase the expression of fear memory, it is not clear how the neural state following fear reminder contribute to the following fear extinction. To address this question, we used resting-state functional magnetic resonance imaging (rs-fMRI) to measure spontaneous neuronal activity and functional connectivity (RSFC) following fear reminder. Some brain regions such as dorsal anterior cingulate (dACC) and ventromedial prefrontal cortex (vmPFC) showed increased amplitude of LFF (ALFF) in the fear reminder group than the no reminder group following fear reminder. More importantly, there was much stronger functional connectivity between the amygdala and vmPFC in the fear reminder group than those in the no reminder group. These findings suggest that the strong functional connectivity between vmPFC and amygdala following a fear reminder could serve as a key role in the followed-up fear extinction stages, which may contribute to the erasing of fear memory. PMID:26576733

Unraveling the Determinants of Fear of Crime Among Men and Women in Istanbul: Examining the Impact of Perceived Risk and Fear of Sexual Assault.

PubMed

Özaşçılar, Mine; Ziyalar, Neylan

2017-07-01

Studies have examined university students' fear of crime focusing on the relationship between the fear of sexual assault and fear of other crimes, termed the shadow of sexual assault hypothesis; however, no study to date has examined the shadow thesis in a Turkish context. Drawing on the shadow thesis, using a sample of 723 university students in Istanbul, this study focuses on the effect of fear of sexual assault and perceived risk of crime to general fear of crime among university students in Istanbul. Also, the predictors of fear of crime are explored to examine the relationship between lifestyle characteristics, constrained behaviors, and fear. The findings of the study supported the shadow thesis, indicating that fear of sexual assault shaped the nonsexual crimes, especially crimes involving face-to-face confrontations between the victim and offender. Furthermore, lifestyle characteristics are correlated with the men's fear of nonsexual crimes, particularly fear of robbery, aggravated assault, and burglary home.

Spontaneous brain activity following fear reminder of fear conditioning by using resting-state functional MRI.

PubMed

Feng, Pan; Zheng, Yong; Feng, Tingyong

2015-11-18

Although disrupting reconsolidation may be a promising approach to attenuate or erase the expression of fear memory, it is not clear how the neural state following fear reminder contribute to the following fear extinction. To address this question, we used resting-state functional magnetic resonance imaging (rs-fMRI) to measure spontaneous neuronal activity and functional connectivity (RSFC) following fear reminder. Some brain regions such as dorsal anterior cingulate (dACC) and ventromedial prefrontal cortex (vmPFC) showed increased amplitude of LFF (ALFF) in the fear reminder group than the no reminder group following fear reminder. More importantly, there was much stronger functional connectivity between the amygdala and vmPFC in the fear reminder group than those in the no reminder group. These findings suggest that the strong functional connectivity between vmPFC and amygdala following a fear reminder could serve as a key role in the followed-up fear extinction stages, which may contribute to the erasing of fear memory.

Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval.

PubMed

Boukezzi, Sarah; Silva, Catarina; Nazarian, Bruno; Rousseau, Pierre-François; Guedj, Eric; Valenzuela-Moguillansky, Camila; Khalfa, Stéphanie

2017-01-01

Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR.

Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval

PubMed Central

Boukezzi, Sarah; Silva, Catarina; Nazarian, Bruno; Rousseau, Pierre-François; Guedj, Eric; Valenzuela-Moguillansky, Camila; Khalfa, Stéphanie

2017-01-01

Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR. PMID:28659851

Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model.

PubMed

Keller, Samantha M; Schreiber, William B; Stanfield, Briana R; Knox, Dayan

2015-01-01

Using the single prolonged stress (SPS) animal model of post-traumatic stress disorder (PTSD), previous studies suggest that enhanced glucocorticoid receptor (GR) expression leads to cued fear extinction retention deficits. However, it is unknown how the endogenous ligand of GRs, corticosterone (CORT), may contribute to extinction retention deficits in the SPS model. Given that CORT synthesis during fear learning is critical for fear memory consolidation and SPS enhances GR expression, CORT synthesis during fear memory formation could strengthen fear memory in SPS rats by enhancing GR activation during fear learning. In turn, this could lead to cued fear extinction retention deficits. We tested the hypothesis that CORT synthesis during fear learning leads to cued fear extinction retention deficits in SPS rats by administering the CORT synthesis inhibitor metyrapone to SPS and control rats prior to fear conditioning, and observed the effect this had on extinction memory. Inhibiting CORT synthesis during fear memory formation in control rats tended to decrease cued freezing, though this effect never reached statistical significance. Contrary to our hypothesis, inhibiting CORT synthesis during fear memory formation disrupted extinction retention in SPS rats. This finding suggests that even though SPS exposure leads to cued fear extinction memory deficits, CORT synthesis during fear memory formation enhances extinction retention in SPS rats. This suggests that stress-induced CORT synthesis in previously stressed rats can be beneficial. Copyright © 2015 Elsevier B.V. All rights reserved.

Living in the nuclear age: An Australian study of children's and adolescent's fears

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slee, P.T.; Cross, D.G.

Developmental changes in children's fears with a particular focus on fears of nuclear war were studied in a sample of 1243 Australian children and adolescents aged between 4-19 years. The average number of fears reported per child was 9.3. Females reported significantly more fears than males. Developmental changes also were apparent with animal and supernatural fears in the youngest age group giving way to social fears and fear of war in the older age brackets. An average of 67.4% of the sample expressed a fear of nuclear war. The implications of this finding for parents and educators are discussed.

Erasing fear memories with extinction training

PubMed Central

Quirk, Gregory J.; Paré, Denis; Richardson, Rick; Herry, Cyril; Monfils, Marie H.; Schiller, Daniela; Vicentic, Aleksandra

2012-01-01

Decades of behavioral studies have confirmed that extinction does not erase classically-conditioned fear memories. For this reason, research efforts have focused on the mechanisms underlying the development of extinction-induced inhibition within fear circuits. However, recent studies in rodents have uncovered mechanisms that stabilize and destabilize fear memories, opening the possibility that extinction might be used to erase fear memories. This symposium focuses on several of these new developments, which involve the timing of extinction training. Extinction-induced erasure of fear occurs in very young rats, but is lost with the development of perineuronal nets in the amygdala that render fear memories impervious to extinction. Moreover, extinction administered during the reconsolidation phase, when fear memory is destabilized, updates the fear association as safe, thereby preventing the return of fear, in both rats and humans. The use of modified extinction protocols to eliminate fear memories complements existing pharmacological strategies for strengthening extinction. PMID:21068303

In the face of fear: Anxiety sensitizes defensive responses to fearful faces

PubMed Central

Grillon, Christian; Charney, Danielle R.

2011-01-01

Fearful faces readily activate the amygdala. Yet, whether fearful faces evoke fear is unclear. Startle studies show no potentiation of startle by fearful faces, suggesting that such stimuli do not activate defense mechanisms. However, the response to biologically relevant stimuli may be sensitized by anxiety. The present study tested the hypothesis that startle would not be potentiated by fearful faces in a safe context, but that startle would be larger during fearful faces compared to neutral faces in a threat-of-shock context. Subjects viewed fearful and neutral faces in alternating periods of safety and threat of shock. Acoustic startle stimuli were presented in the presence and absence of the faces. Startle was transiently potentiated by fearful faces compared to neutral faces in the threat periods. This suggests that although fearful faces do not prompt behavioral mobilization in an innocuous context, they can do so in an anxiogenic one. PMID:21824155

Fear conditioning to subliminal fear relevant and non fear relevant stimuli.

PubMed

Lipp, Ottmar V; Kempnich, Clare; Jee, Sang Hoon; Arnold, Derek H

2014-01-01

A growing body of evidence suggests that conscious visual awareness is not a prerequisite for human fear learning. For instance, humans can learn to be fearful of subliminal fear relevant images--images depicting stimuli thought to have been fear relevant in our evolutionary context, such as snakes, spiders, and angry human faces. Such stimuli could have a privileged status in relation to manipulations used to suppress usually salient images from awareness, possibly due to the existence of a designated sub-cortical 'fear module'. Here we assess this proposition, and find it wanting. We use binocular masking to suppress awareness of images of snakes and wallabies (particularly cute, non-threatening marsupials). We find that subliminal presentations of both classes of image can induce differential fear conditioning. These data show that learning, as indexed by fear conditioning, is neither contingent on conscious visual awareness nor on subliminal conditional stimuli being fear relevant.

Better safe than sorry: simplistic fear-relevant stimuli capture attention.

PubMed

Forbes, Sarah J; Purkis, Helena M; Lipp, Ottmar V

2011-08-01

It has been consistently demonstrated that fear-relevant images capture attention preferentially over fear-irrelevant images. Current theory suggests that this faster processing could be mediated by an evolved module that allows certain stimulus features to attract attention automatically, prior to the detailed processing of the image. The present research investigated whether simplified images of fear-relevant stimuli would produce interference with target detection in a visual search task. In Experiment 1, silhouettes and degraded silhouettes of fear-relevant animals produced more interference than did the fear-irrelevant images. Experiment 2, compared the effects of fear-relevant and fear-irrelevant distracters and confirmed that the interference produced by fear-relevant distracters was not an effect of novelty. Experiment 3 suggested that fear-relevant stimuli produced interference regardless of whether participants were instructed as to the content of the images. The three experiments indicate that even very simplistic images of fear-relevant animals can divert attention.

Uplifting Fear Appeals: Considering the Role of Hope in Fear-Based Persuasive Messages.

PubMed

Nabi, Robin L; Myrick, Jessica Gall

2018-01-09

Fear appeal research has focused, understandably, on fear as the primary emotion motivating attitude and behavior change. However, while the threat component of fear appeals associates with fear responses, a fear appeals' efficacy component likely associates with a different emotional experience: hope. Drawing from appraisal theories of emotion in particular, this article theorizes about the role of hope in fear appeals, testing hypotheses with two existing data sets collected within the context of sun safety messages. In both studies, significant interactions between hope and self-efficacy emerged to predict behavioral intentions. Notable main effects for hope also emerged, though with less consistency. Further, these effects persisted despite controlling for the four cognitions typically considered central to fear appeal effectiveness. These results, consistent across two samples, support the claim that feelings of hope in response to fear appeals contribute to their persuasive success. Implications for developing a recursive model of fear appeal processing are discussed.

8 CFR 1208.6 - Disclosure to third parties.

Code of Federal Regulations, 2010 CFR

2010-01-01

... application, records pertaining to any credible fear determination conducted pursuant to § 1208.30, and records pertaining to any reasonable fear determination conducted pursuant to § 1208.31, shall not be... a credible fear or reasonable fear interview, or received a credible fear or reasonable fear review...

Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner.

PubMed

Bouchet, Courtney A; Lloyd, Brian A; Loetz, Esteban C; Farmer, Caroline E; Ostrovskyy, Mykola; Haddad, Natalie; Foright, Rebecca M; Greenwood, Benjamin N

2017-08-01

Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can enhance the acquisition and consolidation of fear extinction in male rats, but the effects of exercise on relapse of fear after extinction are not well understood. Here, we characterized the effects of 2 h of voluntary exercise during the consolidation phase of contextual or auditory fear extinction learning on long-term fear extinction memory and renewal in adult, male and female, Long-Evans rats. Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. Fear memories of discrete cues, rather than of contextual ones, may be most susceptible to exercise-augmented extinction, especially in males. Additionally, exercise seems to have the biggest impact on fear relapse phenomena, even if fear extinction memories themselves are only minimally enhanced. © 2017 Bouchet et al.; Published by Cold Spring Harbor Laboratory Press.

The Genetic Covariation between Fear Conditioning and Self-Report Fears

PubMed Central

Hettema, John M.; Annas, Peter; Neale, Michael C.; Fredrikson, Mats; Sci, Dr Med; Kendler, Kenneth S.

2008-01-01

Background Fear conditioning is a traditional model for the acquisition of phobias, while behavioral therapies utilize processes underlying extinction to treat phobic and other anxiety disorders. Furthermore, fear conditioning has been proposed as an endophenotype for genetic studies of anxiety disorders. While prior studies have demonstrated that fear conditioning and self-report fears are heritable, no studies have determined whether they share a common genetic basis. Methods We obtained fear conditioning data from 173 twin pairs from the Swedish Twin Registry who also provided self-report ratings of 16 common fears. Using multivariate structural equation modeling, we analyzed factor-derived scores for the subjective fear ratings together with the electrophysiologic skin conductance responses during habituation, acquisition, and extinction to determine the extent of their genetic covariation. Results Phenotypic correlations between experimental and self-report fear measures were modest and, and counter-intuitively, negative; that is, subjects who reported themselves as more fearful had smaller electrophysiologic responses. Best-fit models estimated a significant (negative) genetic correlation between them, although genetic factors underlying fear conditioning accounted for only 9% of individual differences in self-report fears. Conclusions Experimentally-derived fear conditioning measures share only a small portion of the genetic factors underlying individual differences in subjective fears, cautioning against relying too heavily on the former as an endophenotype for genetic studies of phobic disorders. PMID:17698042

COASTAL CONDITIONS IN THE VIRGINIAN PROVINCE (CAPE COD TO CAPE HENRY)

EPA Science Inventory

The U.S. EPA Environmental Monitoring and Assessment Program (EMAP) collected ecological condition data during 1990 through 1993 from the estuarine waters of the Virginian Biogeographic Province (Cape Henry to Cape Cod) to answer broad-scale questions on environmental conditions...

8 CFR 208.6 - Disclosure to third parties.

Code of Federal Regulations, 2010 CFR

2010-01-01

... credible fear determination conducted pursuant to § 208.30, and records pertaining to any reasonable fear... that a specific alien has applied for asylum, received a credible fear or reasonable fear interview, or received a credible fear or reasonable fear review shall also be protected from disclosure. The Service...

Resting-state functional connectivity between amygdala and the ventromedial prefrontal cortex following fear reminder predicts fear extinction.

PubMed

Feng, Pan; Zheng, Yong; Feng, Tingyong

2016-06-01

Investigations of fear conditioning have elucidated the neural mechanisms of fear acquisition, consolidation and extinction, but it is not clear how the neural activation following fear reminder influence the following extinction. To address this question, we measured human brain activity following fear reminder using resting-state functional magnetic resonance imaging, and investigated whether the extinction effect can be predicted by resting-state functional connectivity (RSFC). Behaviorally, we found no significant differences of fear ratings between the reminder group and the no reminder group at the fear acquisition and extinction stages, but spontaneous recovery during re-extinction stage appeared only in the no reminder group. Imaging data showed that functional connectivity between ventromedial prefrontal cortex (vmPFC) and amygdala in the reminder group was greater than that in the no reminder group after fear memory reactivation. More importantly, the functional connectivity between amygdala and vmPFC of the reminder group after fear memory reactivation was positively correlated with extinction effect. These results suggest RSFC between amygdala and the vmPFC following fear reminder can predict fear extinction, which provide important insight into the neural mechanisms of fear memory after fear memory reactivation. © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Behavioral mechanisms of context fear generalization in mice

PubMed Central

Huckleberry, Kylie A.; Ferguson, Laura B.

2016-01-01

There is growing interest in generalization of learned contextual fear, driven in part by the hypothesis that mood and anxiety disorders stem from impaired hippocampal mechanisms of fear generalization and discrimination. However, there has been relatively little investigation of the behavioral and procedural mechanisms that might control generalization of contextual fear. We assessed the relative contribution of different contextual features to context fear generalization and characterized how two common conditioning protocols—foreground (uncued) and background (cued) contextual fear conditioning—affected context fear generalization. In one experiment, mice were fear conditioned in context A, and then tested for contextual fear both in A and in an alternate context created by changing a subset of A's elements. The results suggest that floor configuration and odor are more salient features than chamber shape. A second experiment compared context fear generalization in background and foreground context conditioning. Although foreground conditioning produced more context fear than background conditioning, the two procedures produced equal amounts of generalized fear. Finally, results indicated that the order of context tests (original first versus alternate first) significantly modulates context fear generalization, perhaps because the original and alternate contexts are differentially sensitive to extinction. Overall, results demonstrate that context fear generalization is sensitive to procedural variations and likely reflects the operation of multiple interacting psychological and neural mechanisms. PMID:27918275

Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age

PubMed Central

Graham, Alice M.; Buss, Claudia; Rasmussen, Jerod M.; Rudolph, Marc D.; Demeter, Damion V.; Gilmore, John H.; Styner, Martin; Entringer, Sonja; Wadhwa, Pathik D.; Fair, Damien A.

2015-01-01

The first year of life is an important period for emergence of fear in humans. While animal models have revealed developmental changes in amygdala circuitry accompanying emerging fear, human neural systems involved in early fear development remain poorly understood. To increase understanding of the neural foundations of human fear, it is important to consider parallel cognitive development, which may modulate associations between typical development of early fear and subsequent risk for fear-related psychopathology. We, therefore, examined amygdala functional connectivity with rs-fcMRI in 48 neonates (M=3.65 weeks, SD=1.72), and measured fear and cognitive development at 6-months-of-age. Stronger, positive neonatal amygdala connectivity to several regions, including bilateral anterior insula and ventral striatum, was prospectively associated with higher fear at 6-months. Stronger amygdala connectivity to ventral anterior cingulate/anterior medial prefrontal cortex predicted a specific phenotype of higher fear combined with more advanced cognitive development. Overall, findings demonstrate unique profiles of neonatal amygdala functional connectivity related to emerging fear and cognitive development, which may have implications for normative and pathological fear in later years. Consideration of infant fear in the context of cognitive development will likely contribute to a more nuanced understanding of fear, its neural bases, and its implications for future mental health. PMID:26499255

Manifestations, acquisition and diagnostic categories of dental fear in a self-referred population.

PubMed

Moore, R; Brødsgaard, I; Birn, H

1991-01-01

This study aimed to clarify how manifestations and acquisition relate to diagnostic categories of dental fear in a population of self-referred dental fear patients, since diagnostic criteria specifically related to dental fear have not been validated. DSM III-R diagnostic criteria for phobias were used to compare with four existing dental fear diagnostic categories, referred to as the Seattle system. Subjects were 208 persons with dental fear who were telephone interviewed, of whom a subsample of 155 responded to a mailed Dental Anxiety Scale (DAS), State-Trait Anxiety Inventory and a modified FSS-II Geer Fear Scale (GFS). Personal interviews and a Dental Beliefs Scale of perceived trust and social interaction with dentists were also used to evaluate a subsample of 80 patients selected by sex and high dental fear. Results showed that the majority of the 80 patients (66%), suffered from social embarrassment about their dental fear problem and their inability to do something about it. The largest cause of their fear (84%) was reported to be traumatic dental experiences, especially in childhood (70%). A minority of patients (16%) could not isolate traumatic experiences and had a history of general fearfulness or anxiety. Analysis of GFS data for the 155 subjects showed that fear of snakes and injuries were highest among women; heights and injections among men. Fear of blood was rarely reported. Spearman correlations between GFS individual items and DAS scores indicated functional independence between dental fear and common fears such as blood, injections and enclosures in most cases. Only in specific types of dental fear did these results support Rachman and Lopatka's contention that fears are thought to summate.(ABSTRACT TRUNCATED AT 250 WORDS)

Plasticity of Fear and Safety Neurons of the Amygdala in Response to Fear Extinction

PubMed Central

Sangha, Susan

2015-01-01

Fear inhibition learning induces plasticity and remodeling of circuits within the amygdala. Most studies examine these changes in nondiscriminative fear conditioning paradigms. Using a discriminative fear, safety, and reward conditioning task, Sangha et al. (2013) have previously reported several neural microcircuits within the basal amygdala (BA) which discriminate among these cues, including a subpopulation of neurons responding selectively to a safety cue and not a fear cue. Here, the hypothesis that these “safety” neurons isolated during discriminative conditioning are biased to become fear cue responsive as a result of extinction, when fear behavior diminishes, was tested. Although 41% of “safety” neurons became fear cue responsive as a result of extinction, the data revealed that there was no bias for these neurons to become preferentially responsive during fear extinction compared to the other identified subgroups. In addition to the plasticity seen in the “safety” neurons, 44% of neurons unresponsive to either the fear cue or safety cue during discriminative conditioning became fear cue responsive during extinction. Together these emergent responses to the fear cue as a result of extinction support the hypothesis that new learning underlies extinction. In contrast, 47% of neurons responsive to the fear cue during discriminative conditioning became unresponsive to the fear cue during extinction. These findings are consistent with a suppression of neural responding mediated by inhibitory learning, or, potentially, by direct unlearning. Together, the data support extinction as an active process involving both gains and losses of responses to the fear cue and suggests the final output of the integrated BA circuit in influencing fear behavior is a balance of excitation and inhibition, and perhaps reversal of learning-induced changes. PMID:26733838

Excitatory strength of expressive faces: effects of happy and fear expressions and context on the extinction of a conditioned fear response.

PubMed

Lanzetta, J T; Orr, S P

1986-01-01

In a recent study, Orr and Lanzetta (1984) showed that the excitatory properties of fear facial expressions previously described (Lanzetta & Orr, 1981; Orr & Lanzetta, 1980) do not depend on associative mechanisms; even in the absence of reinforcement, fear faces intensify the emotional reaction to a previously conditioned stimulus and disrupt extinction of an acquired fear response. In conjunction with the findings on acquisition, the failure to obtain extinction suggests that fear faces have some of the functional properties of "prepared" (fear-relevant) stimuli. In the present study we compared the magnitude of conditioned fear responses to happy and fear faces when a potent danger signal, the shock electrodes, are attached or unattached. If fear faces are functionally analogous to prepared stimuli, then, even in the absence of veridical support for an expectation of shock, they should retain excitatory strength, whereas happy faces should not. The results are consistent with this view of fear expressions. In the absence of reinforcement, and with shock electrodes removed, conditioned fear responses and basal levels of arousal were of greater magnitude for the fear-face condition than for the happy-face condition.

Outlook. Number 364

ERIC Educational Resources Information Center

Council for American Private Education, 2011

2011-01-01

Council for American Private Education (CAPE) is a coalition of national associations serving private schools K-12. "Outlook" is published monthly by CAPE. This issue contains the following articles: (1) House Approves Opportunity Scholarships Bill; (2) Lawmakers Discuss Key Issues at CAPE Forum; (3) Digital Now; and (4) CAPE Notes.

Fear of property crime: examining the effects of victimization, vicarious victimization, and perceived risk.

PubMed

Cook, Carrie L; Fox, Kathleen A

2011-01-01

Fear of crime research has primarily focused on fear of crime in general or on fear of specific types of violent crimes. This study builds from this line of research by focusing exclusively on the night fear of six types of property crimes, including fear of burglary while away from home, vehicle theft, bicycle theft, property theft, vandalism, and vehicle burglary. This study examines the effects of victimization, vicarious victimization, and perceived risk on fear of property crime. Survey data from college students reveal that victimization and vicarious victimization were not significant predictors of fear of property crime, whereas perceived risk was a consistent and significant predictor of fear of all property crimes.

NOAA Ship Okeanos Explorer 2012 Field Season in the Northern Gulf of Mexico and U.S. Atlantic Continental Margin

NASA Astrophysics Data System (ADS)

Skarke, A. D.; Lobecker, E.; Malik, M.; VerPlanck, N.

2012-12-01

The NOAA Ship Okeanos Explorer, jointly operated by the NOAA Office of Ocean Exploration and Research and the NOAA Office of Marine and Aviation Operations, is America's only federally managed ship dedicated solely to ocean exploration. The 2012 field season was spent exploring the northern Gulf of Mexico and the U.S. Atlantic continental shelf break and slope. In the Gulf of Mexico, mapping and remotely operated vehicle operations focused on the salt domes and canyons offshore Mississippi and Louisiana, and characterized several of the hundreds of seeps that were detected in the water column backscatter data collected with the ship's Kongsberg EM 302 multibeam sonar (30 kHz) during the 2011 field season. A team of NOAA and non-NOAA partners identified priority frontier areas along the continental shelf and slope between North Carolina and Cape Cod, mapping numerous canyons selected for focused mapping exploration in partnership with the North East Fisheries Science Center, the Mid-Atlantic Regional Council on the Ocean (a state level partnership between various states including NY, NJ, DE, MD, and VA), Woods Hole Oceanographic Institution (WHOI) and Virginia Sea Grant. The 2012 mapping efforts built on data collected during the 2011 field season. Okeanos Explorer data were leveraged by NOAA Ship Henry B. Bigelow to conduct towed camera operations to ground truth multibeam backscatter data for deepwater coral habitat assessment. The Blake Ridge and Cape Fear Diapirs offshore North Carolina were a third focus of exploration operations. Seven 900 meter high cold seeps were discovered in the diapir province. Exploration incorporated WHOI's Sentry autonomous underwater vehicle and its full suite of mapping and oceanographic sensors were used to characterize six seep sites. All data collected by Okeanos Explorer are available via the NOAA public archives with metadata records within 60 to 90 days of the end of each cruise.

A Qualitative study of language barriers between South African health care providers and cross-border migrants.

PubMed

Hunter-Adams, Jo; Rother, Hanna-Andrea

2017-01-31

Communication with health care providers represents an essential part of access to health care for the over 230 million cross-border migrants around the world. In this article, we explore the complexity of health communication from the perspective of cross-border migrants seeking antenatal care in Cape Town, South Africa in order to highlight the importance of high quality medical interpretation. As part of a broader study of migrant maternal and infant nutrition, we conducted a secondary data analysis of semi-structured in-depth interviews (N = 23) with Congolese (n = 7), Somali (n = 8) and Zimbabwean (n = 8) women living in Cape Town, as well as nine focus group discussions (including men: n = 3 and women: n = 6) were conducted with migrant Somalis, Congolese, and Zimbabweans (N = 48). We first used content analysis to gather all data related to language and communication. We then analysed this data thematically. Zimbabwean participants described how the inability to speak the local South African language (IsiXhosa) gave rise to labelling and stereotyping by healthcare staff. Congolese and Somali participants described medical procedures, including tubal ligation, which were performed without consent. Partners often tried to play the role of interpreter, which resulted in loss of income and non-professional medical interpretation. Participants' highlighted fears over unwanted procedures or being unable to access care. Challenges of communication without a common language (and without professional medical interpretation), rather than outright denial of care by healthcare professionals, mediated these encounters. Although there are several factors impeding cross-border migrants' access to health care, effective communication is a prerequisite for quality care. Free-to-patient professional medical interpretation would not only benefit migrant populations but would benefit the broader community where language and health literacy are barriers to accessing health care. Novel approaches to language access may include technology-enabled professional interpretation.

Molecular mechanisms of D-cycloserine in facilitating fear extinction: insights from RNAseq.

PubMed

Malan-Müller, Stefanie; Fairbairn, Lorren; Daniels, Willie M U; Dashti, Mahjoubeh Jalali Sefid; Oakeley, Edward J; Altorfer, Marc; Kidd, Martin; Seedat, Soraya; Gamieldien, Junaid; Hemmings, Sîan Megan Joanna

2016-02-01

D-cycloserine (DCS) has been shown to be effective in facilitating fear extinction in animal and human studies, however the precise mechanisms whereby the co-administration of DCS and behavioural fear extinction reduce fear are still unclear. This study investigated the molecular mechanisms of intrahippocampally administered D-cycloserine in facilitating fear extinction in a contextual fear conditioning animal model. Male Sprague Dawley rats (n = 120) were grouped into four experimental groups (n = 30) based on fear conditioning and intrahippocampal administration of either DCS or saline. The light/dark avoidance test was used to differentiate maladapted (MA) (anxious) from well-adapted (WA) (not anxious) subgroups. RNA extracted from the left dorsal hippocampus was used for RNA sequencing and gene expression data was compared between six fear-conditioned + saline MA (FEAR + SALINE MA) and six fear-conditioned + DCS WA (FEAR + DCS WA) animals. Of the 424 significantly downregulated and 25 significantly upregulated genes identified in the FEAR + DCS WA group compared to the FEAR + SALINE MA group, 121 downregulated and nine upregulated genes were predicted to be relevant to fear conditioning and anxiety and stress-related disorders. The majority of downregulated genes transcribed immune, proinflammatory and oxidative stress systems molecules. These molecules mediate neuroinflammation and cause neuronal damage. DCS also regulated genes involved in learning and memory processes, and genes associated with anxiety, stress-related disorders and co-occurring diseases (e.g., cardiovascular diseases, digestive system diseases and nervous system diseases). Identifying the molecular underpinnings of DCS-mediated fear extinction brings us closer to understanding the process of fear extinction.

Fear during labor: the impact of sexual abuse in adult life.

PubMed

Eberhard-Gran, Malin; Slinning, Kari; Eskild, Anne

2008-12-01

Our aim was to study the occurrence of extreme fear during labor and its association with previous sexual abuse in adult life. All postpartum women (n = 414) in two municipalities in Norway participated in a questionnaire study. Self-reported fear during labor was categorized as "no fear/some fear/extreme fear". Sexual abuse was measured by the Abuse Assessment Screen (AAS). Three percent of the women reported extreme fear during labor, 13% some fear and 84% no fear. In total, 12% had been sexually abused as an adult. Among the women with extreme fear during labor, however, one third had a history of sexual abuse in adult life (crude odds ratio 3.7; 95% CI: 1.0-3.7). When controlling for depression in pregnancy, duration of labor and mode of delivery, the adjusted odds ratio for extreme fear during labor was 4.9 (95% CI: 1.2-19.1). The results suggest that women with a history of sexual abuse in adult life have an increased risk of extreme fear during labor.

Passive avoidance is linked to impaired fear extinction in humans

PubMed Central

Cornwell, Brian R.; Overstreet, Cassie; Krimsky, Marissa; Grillon, Christian

2013-01-01

Conventional wisdom dictates we must face our fears to conquer them. This idea is embodied in exposure-based treatments for anxiety disorders, where the intent of exposure is to reverse a history of avoidant behavior that is thought to fuel a patient’s irrational fears. We tested in humans the relationship between fear and avoidance by combining Pavlovian differential fear conditioning with a novel task for quantifying spontaneous passive avoidant behavior. During self-guided navigation in virtual reality following de novo fear conditioning, we observed participants keeping their distance from the feared object. At the individual level, passive avoidant behavior was highly associated with maladaptive fear expression (fear-potentiated startle) during late extinction training, indicating that extinction learning was impaired following a brief episode of avoidance. Avoidant behavior, however, was not related to initial acquired fear, raising doubt about a straightforward link between physiological fear and behavioral avoidance. We conclude that a deeper understanding of what motivates avoidance may offer a target for early intervention, before fears transition from the rational to the irrational. PMID:23427168

Effective and ineffective use of fear in health promotion campaigns.

PubMed Central

Soames Job, R F

1988-01-01

Health promotion campaigns are typically designed to elicit fear, yet the use of fear is often ineffective in achieving the desired behavior change. Campaigns which attempt to use fear as part of a punishment procedure are unlikely to succeed. Consistent with established principles of learning, fear is most likely to be effective if the campaign allows for the desired behavior to be reinforced by a reduction in the level of fear. This entails five requirements: 1) fear onset should occur before the desired behavior is offered; 2) the event upon which the fear is based should appear to be likely; 3) a specific desired behavior should be offered as part of the campaign; 4) the level of fear elicited should only be such that the desired behavior offered is sufficient to substantially reduce the fear; 5) fear offset should occur as a reinforcer for the desired behavior, confirming its effectiveness. Under some circumstances it may be difficult to ensure that these requirements are met. In general, a positive reinforcement approach may prove to be more effective than the use of fear. PMID:3276236

Fear of progression.

PubMed

Herschbach, Peter; Dinkel, Andreas

2014-01-01

Fear of progression (or fear of recurrence) is an appropriate, rational response to the real threat of cancer and cancer treatments. However, elevated levels of fear of progression can become dysfunctional, affecting well-being, quality of life, and social functioning. Research has shown that fear of progression is one of the most frequent distress symptoms of patients with cancer and with other chronic diseases. As a clear consensus concerning clinically relevant states of fear of progression is currently lacking, it is difficult to provide a valid estimate of the rate of cancer patients who clearly suffer from fear of progression. However, recent systematic reviews suggest that probably 50 % of cancer patients experience moderate to severe fear of progression. Furthermore, many patients express unmet needs in dealing with the fear of cancer spreading. These results underline the necessity to provide effective psychological treatments for clinical levels of fear of progression. A few psychosocial interventions for treating fear of progression have been developed so far. Our own, targeted intervention study showed that dysfunctional fear of progression can be effectively treated with a brief group therapy.

Reconstruction of major maternal and paternal lineages of the Cape Muslim population

PubMed Central

Isaacs, Shafieka; Geduld-Ullah, Tasneem; Benjeddou, Mongi

2013-01-01

The earliest Cape Muslims were brought to the Cape (Cape Town - South Africa) from Africa and Asia from 1652 to 1834. They were part of an involuntary migration of slaves, political prisoners and convicts, and they contributed to the ethnic diversity of the present Cape Muslim population of South Africa. The history of the Cape Muslims has been well documented and researched however no in-depth genetic studies have been undertaken. The aim of the present study was to determine the respective African, Asian and European contributions to the mtDNA (maternal) and Y-chromosomal (paternal) gene pool of the Cape Muslim population, by analyzing DNA samples of 100 unrelated Muslim males born in the Cape Metropolitan area. A panel of six mtDNA and eight Y-chromosome SNP markers were screened using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Overall admixture estimates for the maternal line indicated Asian (0.4168) and African mtDNA (0.4005) as the main contributors. The admixture estimates for the paternal line, however, showed a predominance of the Asian contribution (0.7852). The findings are in accordance with historical data on the origins of the early Cape Muslims. PMID:23885197

Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Mi Hee; Kang, Dong Woo; Jung, Yunjin

2013-12-06

Highlights: •We found CAFÉ, a natural product that suppresses expression and activity of PLD1. •CAPE decreased PLD1 expression by inhibiting NFκB transactivation. •CAPE rapidly inhibited PLD activity via its binding to a Cys837 of PLD1. •PLD1 downregulation by CAPE inhibited invasion and proliferation of glioma cells. -- Abstract: Upregulation of phospholipase D (PLD) is functionally linked with oncogenic signals and tumorigenesis. Caffeic acid phenethyl ester (CAPE) is an active compound of propolis extract that exhibits anti-proliferative, anti-inflammatory, anti-oxidant, and antineoplastic properties. In this study, we demonstrated that CAPE suppressed the expression of PLD1 at the transcriptional level via inhibition ofmore » binding of NFκB to PLD1 promoter. Moreover, CAPE, but not its analogs, bound to a Cys837 residue of PLD1 and inhibited enzymatic activity of PLD. CAPE also decreased activation of matrix metalloproteinases-2 induced by phosphatidic acid, a product of PLD activity. Ultimately, CAPE-induced downregulation of PLD1 suppressed invasion and proliferation of glioma cells. Taken together, the results of this study indicate that CAPE might contribute to anti-neoplastic effect by targeting PLD1.« less

Fear of Death in a Sample of Physicians

PubMed Central

Wood, Keith; Robinson, Paul J.

1984-01-01

Recently, reliable and valid methods of assessing fear of death have been developed. In this study, three well established questionnaires (the Threat Index, the Death Anxiety Scale and the Collett-Lester Fear of Death Scale) were used to assess and compare fear of death in a group of physicians (n = 30) with a group of non-physicians (n = 30). T-tests and hierarchical multiple regression analyses revealed no significant differences between physicians' and non-physicians' fear of death as measured by the Threat Index and Templer's Death Anxiety Scale. The Collett-Lester Fear of Death Scale revealed that physicians were less fearful of death. More specifically, physicians demonstrated less fear on the Collett-Lester subscales, `fear of dying of self' and `fear of dying of others', than did non-physicians. These findings and those of earlier, contradictory research, are discussed. PMID:21279021

Living in Fear of Your Child's Pain: The Parent Fear of Pain Questionnaire

PubMed Central

Simons, Laura E.; Smith, Allison; Kaczynski, Karen; Basch, Molly

2015-01-01

Fear and avoidance have been consistently associated with poor pain-related outcomes in children. In the context of the pediatric pain experience, parent distress and behaviors can be highly influential. The current study validated the Parent Fear of Pain Questionnaire (PFOPQ) to assess a parent's fears and avoidance behaviors associated with their child's pain. Using the PFOPQ in conjunction with measures of parent and child pain-related variables, we tested the Interpersonal Fear Avoidance Model (IFAM). The sample comprised of 321 parents and their child with chronic or new-onset pain who presented to a multidisciplinary outpatient pain clinic. An exploratory factor analysis yielded a 4-factor structure for the PFOPQ consisting of Fear of Pain, Fear of Movement, Fear of School, and Avoidance. As hypothesized, Fear of Pain was most closely related to parent pain catastrophizing and child fear of pain, while Avoidance was most closely related to parent protective behaviors and child avoidance of activities. In testing the IFAM, parent behavior contributed directly and indirectly to child avoidance while parent fear and catastrophizing contributed indirectly to child avoidance through parent behavior and child fear and catastrophizing, in turn, influencing child functional disability levels. The current study provides the first measure of parent pain-related fears and avoidance behaviors and evaluates the theorized IFAM. These results underscore the important influence of parents on child pain-related outcomes and puts forth a psychometrically sound measure to assess parent fear and avoidance in the context of their child's pain. PMID:25630026

A role for midline and intralaminar thalamus in the associative blocking of Pavlovian fear conditioning.

PubMed

Sengupta, Auntora; McNally, Gavan P

2014-01-01

Fear learning occurs in response to positive prediction error, when the expected outcome of a conditioning trial exceeds that predicted by the conditioned stimuli present. This role for error in Pavlovian association formation is best exemplified by the phenomenon of associative blocking, whereby prior fear conditioning of conditioned stimulus (CS) A is able to prevent learning to CSB when they are conditioned in compound. The midline and intralaminar thalamic nuclei (MIT) are well-placed to contribute to fear prediction error because they receive extensive projections from the midbrain periaqueductal gray-which has a key role in fear prediction error-and project extensively to prefrontal cortex and amygdala. Here we used an associative blocking design to study the role of MIT in fear learning. In Stage I rats were trained to fear CSA via pairings with shock. In Stage II rats received compound fear conditioning of CSAB paired with shock. On test, rats that received Stage I training expressed less fear to CSB relative to control rats that did not receive this training. Microinjection of bupivacaine into MIT prior to Stage II training had no effect on the expression of fear during Stage II and had no effect on fear learning in controls, but prevented associative blocking and so enabled fear learning to CSB. These results show an important role for MIT in predictive fear learning and are discussed with reference to previous findings implicating the midline and posterior intralaminar thalamus in fear learning and fear responding.

Living in fear of your child's pain: the Parent Fear of Pain Questionnaire.

PubMed

Simons, Laura E; Smith, Allison; Kaczynski, Karen; Basch, Molly

2015-04-01

Fear and avoidance have been consistently associated with poor pain-related outcomes in children. In the context of the pediatric pain experience, parent distress and behaviors can be highly influential. This study validated the Parent Fear of Pain Questionnaire (PFOPQ) to assess a parent's fears and avoidance behaviors associated with their child's pain. Using the PFOPQ in conjunction with measures of parent and child pain-related variables, we tested the interpersonal fear-avoidance model (IFAM). The sample comprised 321 parents and their child with chronic or new-onset pain who presented to a multidisciplinary outpatient pain clinic. An exploratory factor analysis yielded a 4-factor structure for the PFOPQ consisting of Fear of Pain, Fear of Movement, Fear of School, and Avoidance. As hypothesized, Fear of Pain was most closely related to parent pain catastrophizing and child fear of pain, whereas Avoidance was most closely related to parent protective behaviors and child avoidance of activities. In testing the IFAM, parent behavior contributed directly and indirectly to child avoidance, whereas parent fear and catastrophizing contributed indirectly to child avoidance through parent behavior and child fear and catastrophizing, in turn, influencing child functional disability levels. This study provides the first measure of parent pain-related fears and avoidance behaviors and evaluates the theorized IFAM. These results underscore the important influence of parents on child pain-related outcomes and put forth a psychometrically sound measure to assess parent fear and avoidance in the context of their child's pain.

Fine tuning fear of childbirth: the relationship between Childbirth Fear Questionnaire subscales and demographic and reproductive variables.

PubMed

Fairbrother, Nichole; Thordarson, Dana S; Stoll, Kathrin

2018-02-01

The objective of the current study was to investigate the relationship between the newly developed Childbirth Fear Questionnaire (CFQ) and demographic and reproductive variables. The CFQ was developed in an effort to improve measurement and understanding of women's childbirth fears. To our knowledge the CFQ is the only multidimensional measure of childbirth fears in which (a) multiple domains of childbirth fear are assessed and (b) individual subscales have been psychometrically developed. Participants were 643 pregnant women residing in English-speaking countries, recruited via online forums. Participants completed a set of questionnaires, including the multidimensional CFQ, via an online survey. Given the differences in childbirth fear between nulliparous and multiparous women, findings are stratified by parity. Gestational age was largely unrelated to fear of childbirth. Age, income and education were negatively related to fear of childbirth. Assisted vaginal delivery and episiotomy in a previous pregnancy were positively associated with a fear of pain. Self-reported history of traumatic vaginal birth was associated with higher scores on all aspects of fear of childbirth. History of caesarean birth was not generally associated with increased childbirth fears, but women with a prior, self-reported traumatic caesarean birth reported more fear of future caesarean births. Findings are consistent with previous reports of fear of childbirth. However, the CFQ provides increased specificity with respect to women's childbirth fears. This information is relevant to both education and treatment planning for pregnant women and women wishing to reproduce.

Do complaints of everyday cognitive failures in high schizotypy relate to emotional working memory deficits in the lab?

PubMed

Carrigan, Nicole; Barkus, Emma; Ong, Adriel; Wei, Maryann

2017-10-01

Individuals high on schizotypy complain of increased cognitive failures in everyday life. However, the neuropsychological performance of this group does not consistently indicate underlying ability deficits. It is possible that current neuropsychological tests lack ecological validity. Given the increased affective reactivity of high schizotypes, they may be more sensitive to emotional content interfering with cognitive ability. This study sought to explore whether an affective n-back working memory task would elicit impaired performance in schizotypy, echoing complaints concerning real world cognition. 127 healthy participants completed self-report measures of schizotypy and cognitive failures and an affective n-back working memory task. This task was varied across three levels of load (1- to 3-back) and four types of stimulus emotion (neutral, fearful, happy, sad). Differences between high (n=39) and low (n=48) schizotypy groups on performance outcomes of hits and false alarms were examined, with emotion and load as within-groups variables. As expected, high schizotypes reported heightened vulnerability to cognitive failures. They also demonstrated a relative working memory impairment for emotional versus neutral stimuli, whereas low schizotypes did not. High schizotypes performed most poorly in response to fearful stimuli. For false alarms, there was an interaction between schizotypy, load, and emotion, such that high schizotypy was associated with deficits in response to fearful stimuli only at higher levels of task difficulty. Inclusion of self-reported cognitive failures did not account for this. These findings suggest that the "gap" between subjective and objective cognition in schizotypy may reflect the heightened emotional demands associated with cognitive functioning in the real world, although other factors also seem to play a role. There is a need to improve the ecological validity of objective assessments, whilst also recognizing that self-reported cognitive failures tap into a range of factors difficult to assess in the lab, including emotion. Cognitive interventions for at-risk individuals will likely be more beneficial if they address emotional processing alongside other aspects of cognition. Copyright © 2017 Elsevier Inc. All rights reserved.

The dangers of feeling like a fake.

PubMed

de Vries, Manfred F R Kets

2005-09-01

In many walks of life-and business is no exception-there are high achievers who believe that they are complete fakes. To the outside observer, these individuals appear to be remarkably accomplished; often they are extremely successful leaders with staggering lists of achievements. These neurotic impostors--as psychologists call them--are not guilty of false humility. The sense of being a fraud is the flip side of giftedness and causes a great many talented, hardworking, and capable leaders to believe that they don't deserve their success. "Bluffing" their way through life (as they see it), they are haunted by the constant fear of exposure. With every success, they think, "I was lucky this time, fooling everyone, but will my luck hold? When will people discover that I'm not up to the job?" In his career as a management professor, consultant, leadership coach, and psychoanalyst, Manfred F.R. Kets de Vries has found neurotic impostors at all levels of organizations. In this article, he explores the subject of neurotic imposture and outlines its classic symptoms: fear of failure, fear of success, perfectionism, procrastination, and workaholism. He then describes how perfectionist overachievers can damage their careers, their colleagues' morale, and the bottom line by allowing anxiety to trigger self-handicapping behavior and cripple the very organizations they're trying so hard to please. Finally, Kets de Vries offers advice on how to limit the incidence of neurotic imposture and mitigate its damage through discreet vigilance, appropriate intervention, and constructive support.

77 FR 26048 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

...--Cape Adare; ASPA 160--Cape Geology; and, ASPA 171--Narebski Point. Access to these sites will be on an... Shirreff; ASPA 150--Ardley Island; ASPA 158--Cape Adare; ASPA 160--Cape Geology; and, ASPA 171-- Narebski...

Fibrinolytic activity and dose-dependent effect of incubating human blood clots in caffeic acid phenethyl ester: in vitro assays.

PubMed

Elnager, Abuzar; Hassan, Rosline; Idris, Zamzuri; Mustafa, Zulkifli; Wan-Arfah, Nadiah; Sulaiman, S A; Gan, Siew Hua; Abdullah, Wan Zaidah

2015-01-01

Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods. Standardized human whole blood (WB) clots were incubated in either blank controls or different concentrations of CAPE (3.75, 7.50, 15.00, 22.50, and 30.00 mM). After 3 hours, D-dimer (DD) levels and WB clot weights were measured for each concentration. Thromboelastography (TEG) parameters were recorded following CAPE incubation, and fibrin morphology was examined under a confocal microscope. Results. Overall, mean DD (μg/mL) levels were significantly different across samples incubated with different CAPE concentrations, and the median pre- and postincubation WB clot weights (grams) were significantly decreased for each CAPE concentration. Fibrin removal was observed microscopically and indicated dose-dependent effects. Based on the TEG test, the Ly30 fibrinolytic parameter was significantly different between samples incubated with two different CAPE concentrations (15.0 and 22.50 mM). The 50% effective dose (ED50) of CAPE (based on DD) was 1.99 mg/mL. Conclusions. This study suggests that CAPE possesses fibrinolytic activity following in vitro incubation and that it has dose-dependent activities. Therefore, further investigation into CAPE as a potential alternative thrombolytic agent should be conducted.

Caffeic Acid Phenethyl Ester Induces N-myc Downstream Regulated Gene 1 to Inhibit Cell Proliferation and Invasion of Human Nasopharyngeal Cancer Cells

PubMed Central

Chiang, Kun-Chun; Yang, Shih-Wei; Chang, Kai-Ping; Feng, Tsui-Hsia; Chang, Kang-Shuo; Tsui, Ke-Hung; Shin, Yi-Syuan; Chen, Chiu-Chun; Chao, Mei

2018-01-01

Caffeic acid phenethyl ester (CAPE), a bioactive component extracted from propolis, is widely studied due to its anti-cancer effect. Nasopharyngeal carcinoma (NPC) is distinct from other head and neck carcinomas and has a high risk of distant metastases. N-myc downstream regulated gene 1 (NDRG1) is demonstrated as a tumor suppressor gene in several cancers. Our result showed that CAPE treatment could repress NPC cell growth, through induction of S phase cell cycle arrest, and invasion. CAPE treatment stimulated NDRG1 expression in NPC cells. NDRG1 knockdown increased NPC cell proliferation and invasion and rendered NPC cells less responsive to CAPE growth-inhibiting effect, indicating CAPE repressed NPC cell growth partly through NDRG1indcution. CAPE treatment increased phosphorylation of ERK, JNK, and p38 in a dose- and time-dependent manner. Pre-treatments by inhibitors of ERK (PD0325901), JNK (SP600125), or p38 (SB201290), respectively, all could partly inhibit the CAPE effect on NDRG1 induction in NPC cells. Further, STAT3 activity was also repressed by CAPE in NPC cells. In summary, CAPE attenuates NPC cell proliferation and invasion by upregulating NDRG1 expression via MAPK pathway and by inhibiting phosphorylation of STAT3. Considering the poor prognosis of NPC patients with metastasis, CAPE could be a promising agent against NPC. PMID:29738439

Validation of the Spanish adaptation of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V).

PubMed

Núñez-Batalla, Faustino; Morato-Galán, Marta; García-López, Isabel; Ávila-Menéndez, Arántzazu

2015-01-01

The Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) was developed.to promote a standardised approach to evaluating and documenting auditory perceptual judgments of vocal quality. This tool was originally developed in English language and its Spanish version is still inexistent. The aim of this study was to develop a Spanish adaptation of CAPE-V and to examine the reliability and empirical validity of this Spanish version. To adapt the CAPE-V protocol to the Spanish language, we proposed 6 phrases phonetically designed according to the CAPE-V requirements. Prospective instrument validation was performed. The validity of the Spanish version of the CAPE-V was examined in 4 ways: intra-rater reliability, inter-rater reliability and CAPE-V versus GRABS judgments. Inter-rater reliability coefficients for the CAPE-V ranged from 0.93 for overall severity to 0.54 for intensity; intra-rater reliability ranged from 0.98 for overall severity to 0.85 for intensity. The comparison of judgments between GRABS and CAPE-V ranged from 0.86 for overall severity to 0.61 for breathiness. The present study supports the use of the Spanish version of CAPE-V because of its validity and reliability. Copyright © 2014 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved.

Experience-dependent modification of a central amygdala fear circuit

PubMed Central

Li, Haohong; Penzo, Mario A.; Taniguchi, Hiroki; Kopec, Charles D.; Huang, Z. Josh; Li, Bo

2013-01-01

The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, how CeA contributes to the learning and expression of fear is unclear. Here we show in mice that fear conditioning induces robust plasticity of excitatory synapses onto inhibitory neurons in the lateral subdivision of CeA (CeL). This experience-dependent plasticity is cell-specific, bidirectional, and expressed presynaptically by inputs from the lateral amygdala. In particular, preventing synaptic potentiation onto somatostatin-positive neurons impairs fear memory formation. Furthermore, activation of these neurons is necessary for fear memory recall and sufficient to drive fear responses. Our findings support a model in which the fear conditioning-induced synaptic modifications in CeL favor the activation of somatostatin-positive neurons, which inhibit CeL output thereby disinhibiting the medial subdivision of CeA and releasing fear expression. PMID:23354330

Fears of institutionalized mentally retarded adults.

PubMed

Sternlicht, M

1979-01-01

The patterns of fears of institutionalized mentally retarded adults were studied in a sample of i2 moderately retarded men and women between the ages of 21-49. The direct questioning method was employed. Two interviews were held, two weeks apart; the first interview elicited the Ss' fears, while the second concerned the fears of their friends. A total of 146 responses were obtained, and these were categorized according to the types of fears: supernatural-natural events, animals, physical injury, psychological stress, egocentric responses, and no fears. The Ss displayed a higher percentage of fears in the preoperational stage than in the concrete operational stage. In a comparison of male to female fears, only one category, that of fears of animals, reached significance. The study suggested that the same developmental trend of fears that appears in normal children appears in the retarded as well, and these fears follow Piaget's level of cognitive development, proceeding from egocentric perceptions of causality to realistic cause and effect thinking.

Winds and the orientation of a coastal plane estuary plume

NASA Astrophysics Data System (ADS)

Xia, Meng; Xie, Lian; Pietrafesa, Leonard J.

2010-10-01

Based on a calibrated coastal plane estuary plume model, ideal model hindcasts of estuary plumes are used to describe the evolution of the plume pattern in response to river discharge and local wind forcing by selecting a typical partially mixed estuary (the Cape Fear River Estuary or CFRE). With the help of an existing calibrated plume model, as described by Xia et al. (2007), simulations were conducted using different parameters to evaluate the plume behavior type and its change associated with the variation of wind forcing and river discharge. The simulations indicate that relatively moderate winds can mechanically reverse the flow direction of the plume. Downwelling favorably wind will pin the plume to the coasts while the upwelling plume could induce plume from the left side to right side in the application to CFRE. It was found that six major types of plumes may occur in the estuary and in the corresponding coastal ocean. To better understand these plumes in the CFRE and other similar river estuary systems, we also investigated how the plumes transition from one type to another. Results showed that wind direction, wind speed, and sometimes river discharge contribute to plume transitions.

The effect of changing topography on coastal tides and storm surge: a historical perspective

NASA Astrophysics Data System (ADS)

Talke, Stefan; Jay, David; Helaire, Lumas; Familkhalili, Ramin

2016-11-01

Over decadal and century time scales, the topography of coastal harbors changes due to natural and anthropogenic factors. These changes alter the mass and momentum balances of incoming waves, producing measureable changes to tides and surge. Here we use recently recovered archival data, historic bathymetric charts, and numerical models to assess changes in multiple estuaries. In the Columbia River estuary, Ems estuary, and Cape Fear Estuary, channel deepening has increased the M2 tide between 10 to 100% since the 19th century, due to both reduced frictional effects and altered resonance. The bathymetric perturbations also affect the propagation of other long-period waves: in Wilmington (NC), the worst-case scenario CAT-5 storm surge is modeled to increase by 50% since 19th century conditions. Similarly, in New York harbor, the 10 year storm-tide level has outpaced sea-level rise by nearly 30 cm since 1850. In the Columbia River, reduced friction has decreased the river slope (reducing water levels), but also led to amplification of both tides and flood waves. Going forward, historical bathymetric change may provide a clue to the future effects of climate change and continued anthropogenic development. National Science Foundation; US Army Corp of Engineers.

Fears and Phobias

MedlinePlus

... a strong swimmer might have a fear of deep water. In this case, the fear is helpful because it cautions the person to stay safe. Someone could overcome this fear by learning how to swim safely. A fear can be ...

Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Y.-J.; Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan; Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan

2005-11-15

Purpose: Caffeic acid phenethyl ester (CAPE), a component of propolis, was reported capable of depleting glutathione (GSH). We subsequently examined the radiosensitizing effect of CAPE and its toxicity. Methods and Materials: The effects of CAPE on GSH level, GSH metabolism enzyme activities, NF-{kappa}B activity, and radiosensitivity in mouse CT26 colorectal adenocarcinoma cells were determined. BALB/c mouse with CT26 cells implantation was used as a syngeneic in vivo model for evaluation of treatment and toxicity end points. Results: CAPE entered CT26 cells rapidly and depleted intracellular GSH in CT26 cells, but not in bone marrow cells. Pretreatment with nontoxic doses ofmore » CAPE significantly enhanced cell killing by ionizing radiation (IR) with sensitizer enhancement ratios up to 2.2. Pretreatment of CT26 cells with N-acetyl-L-cysteine reversed the GSH depletion activity and partially blocked the radiosensitizing effect of CAPE. CAPE treatment in CT26 cells increased glutathione peroxidase, decreased glutathione reductase, and did not affect glutathione S-transferase or {gamma}-glutamyl transpeptidase activity. Radiation activated NF-{kappa}B was reversed by CAPE pretreatment. In vivo study revealed that pretreatment with CAPE before IR resulted in greater inhibition of tumor growth and prolongation of survival in comparison with IR alone. Pretreatment with CAPE neither affected body weights nor produced hepatic, renal, or hematopoietic toxicity. Conclusions: CAPE sensitizes CT26 colorectal adenocarcinoma to IR, which may be via depleting GSH and inhibiting NF-{kappa}B activity, without toxicity to bone marrow, liver, and kidney.« less

What Can Ethobehavioral Studies Tell Us About The Brain’s Fear System?

PubMed Central

Pellman, Blake A.; Kim, Jeansok J.

2016-01-01

Foraging-associated predation risk is a natural problem all prey must face. Fear evolved due to its protective functions, guiding and shaping behaviors that help animals adapt to various ecological challenges. Despite the breadth of risky situations in nature that demand diversity in fear behaviors, contemporary neurobiological models of fear stem largely from Pavlovian fear conditioning studies that focus on how a particular cue becomes capable of eliciting learned fear responses, thus oversimplifying the brain’s fear system. Here we review fear from functional, mechanistic, and phylogenetic perspectives where environmental threats cause animals to alter their foraging strategies in terms of spatial and temporal navigation, and discuss whether the inferences we draw from fear conditioning studies operate in the natural world. PMID:27130660

Where There is Smoke There is Fear-Impaired Contextual Inhibition of Conditioned Fear in Smokers.

PubMed

Haaker, Jan; Lonsdorf, Tina B; Schümann, Dirk; Bunzeck, Nico; Peters, Jan; Sommer, Tobias; Kalisch, Raffael

2017-07-01

The odds-ratio of smoking is elevated in populations with neuropsychiatric diseases, in particular in the highly prevalent diagnoses of post-traumatic stress and anxiety disorders. Yet, the association between smoking and a key dimensional phenotype of these disorders-maladaptive deficits in fear learning and fear inhibition-is unclear. We therefore investigated acquisition and memory of fear and fear inhibition in healthy smoking and non-smoking participants (N=349, 22% smokers). We employed a well validated paradigm of context-dependent fear and safety learning (day 1) including a memory retrieval on day 2. During fear learning, a geometrical shape was associated with an aversive electrical stimulation (classical fear conditioning, in danger context) and fear responses were extinguished within another context (extinction learning, in safe context). On day 2, the conditioned stimuli were presented again in both contexts, without any aversive stimulation. Autonomic physiological measurements of skin conductance responses as well as subjective evaluations of fear and expectancy of the aversive stimulation were acquired. We found that impairment of fear inhibition (extinction) in the safe context during learning (day 1) was associated with the amount of pack-years in smokers. During retrieval of fear memories (day 2), smokers showed an impairment of contextual (safety context-related) fear inhibition as compared with non-smokers. These effects were found in physiological as well as subjective measures of fear. We provide initial evidence that smokers as compared with non-smokers show an impairment of fear inhibition. We propose that smokers have a deficit in integrating contextual signs of safety, which is a hallmark of post-traumatic stress and anxiety disorders.

Prevalence of childbirth fear in an Australian sample of pregnant women.

PubMed

Toohill, Jocelyn; Fenwick, Jennifer; Gamble, Jenny; Creedy, Debra K

2014-08-14

Childbirth fear is reported to affect around 20% of women. However reporting on levels of symptom severity vary. Unlike Scandinavian countries, there has been limited focus on childbirth fear in Australia. The aim of this paper is to determine the prevalence of low, moderate, high and severe levels of childbirth fear in a large representative sample of pregnant women drawn from a large randomised controlled trial and identify demographic and obstetric characteristics associated with childbirth fear. Using a descriptive cross-sectional design, 1,410 women in their second trimester were recruited from one of three public hospitals in south-east Queensland. Participants were screened for childbirth fear using the Wijma Delivery Expectancy/Experience Questionnaire Version A (WDEQ-A). Associations of demographic and obstetric factors and levels of childbirth fear between nulliparous and multiparous women were investigated. Prevalence of childbirth fear was 24% overall, with 31.5% of nulliparous women reporting high levels of fear (score ≥ 66 on the WDEQ-A) compared to 18% of multiparous women. Childbirth fear was associated with paid employment, parity, and mode of last birth, with higher levels of fear in first time mothers (p < 0.001) and in women who had previously had an operative birth (p < 0.001). Prevalence of childbirth fear in Australian women was comparable to international rates. Significant factors associated with childbirth fear were being in paid employment, and obstetric characteristics such as parity and birth mode in the previous pregnancy. First time mothers had higher levels of fear than women who had birthed before. A previous operative birth was fear provoking. Experiencing a previous normal birth was protective of childbirth fear.

Interference effects of transcranial direct current stimulation over the right frontal cortex and adrenergic system on conditioned fear.

PubMed

Nasehi, Mohammad; Soltanpour, Reyhaneh; Ebrahimi-Ghiri, Mohaddeseh; Zarrabian, Shahram; Zarrindast, Mohammad-Reza

2017-11-01

The effects of pharmacological interventions on fear memory have widely been studied, but there are very few studies about the effects of brain electrical stimulation on fear memory function. Therefore, our aim was to determine whether anodal/cathodal transcranial direct current stimulation (tDCS) over the right frontal cortex would modify propranolol-induced contextual and auditory fear memory deficits, before or after training. The adult NMRI male mice were randomly assigned into three groups: the sham group, the anodal tDCS group, and the cathodal tDCS group. Fear memories were evaluated using a classical fear conditioning apparatus. While the anodal stimulation did not affect fear retrieval, post-training cathodal stimulation improved fear memory retrieval. Regardless of when propranolol (0.1 mg/kg) was administered, it impaired fear memory retrieval. However, when anodal stimulation and propranolol were applied prior to the training, contextual fear memory retrieval was increased and auditory fear memory was reversed. An enhanced contextual retrieval was also observed when propranolol was administered prior to the training and stimulation occurred after the training. Only when the stimulation occurred prior to the training and propranolol was administered after the training was there a selective improvement in contextual fear memory retrieval, leaving the auditory fear memory retrieval impaired. Interestingly, cathodal stimulation improved the effects of propranolol on auditory fear memory only when it occurred prior to the training. The results highlight possible improving effects for anodal/cathodal tDCS on propranolol-induced deficits on fear memories. The timing of the interventions related to the specific phases of memory formation is important in modulating fear behaviors.

Stimulus fear relevance and the speed, magnitude, and robustness of vicariously learned fear.

PubMed

Dunne, Güler; Reynolds, Gemma; Askew, Chris

2017-08-01

Superior learning for fear-relevant stimuli is typically indicated in the laboratory by faster acquisition of fear responses, greater learned fear, and enhanced resistance to extinction. Three experiments investigated the speed, magnitude, and robustness of UK children's (6-10 years; N = 290; 122 boys, 168 girls) vicariously learned fear responses for three types of stimuli. In two experiments, children were presented with pictures of novel animals (Australian marsupials) and flowers (fear-irrelevant stimuli) alone (control) or together with faces expressing fear or happiness. To determine learning speed the number of stimulus-face pairings seen by children was varied (1, 10, or 30 trials). Robustness of learning was examined via repeated extinction procedures over 3 weeks. A third experiment compared the magnitude and robustness of vicarious fear learning for snakes and marsupials. Significant increases in fear responses were found for snakes, marsupials and flowers. There was no indication that vicarious learning for marsupials was faster than for flowers. Moreover, vicariously learned fear was neither greater nor more robust for snakes compared to marsupials, or for marsupials compared to flowers. These findings suggest that for this age group stimulus fear relevance may have little influence on vicarious fear learning. Copyright © 2017 Elsevier Ltd. All rights reserved.

An inquiry about clinical death--considering spiritual pain.

PubMed

Deeken, Alfons

2009-06-01

According to a paper published by the International Work Group on Death, Dying and Bereavement, "Each person has a spiritual dimension." That means each person has spiritual energy and spiritual needs. In facing death, a patient suffers spiritual pain and needs spiritual care. This paper describes what spirituality and spiritual pain mean. It identifies nine types of fears and anxieties about death which become a source of spiritual pain: 1. Fear of pain; 2. Fear of loneliness; 3. Fear of unpleasant experiences; 4. Fear of becoming a burden to the family and to society; 5. Anxiety towards the unknown; 6. Fear of death resulting from fear of life; 7. Fear of death as a feeling that one's life task is still incomplete; 8. Fear of death as fear of personal extinction; 9. Fear of death as fear of judgment and punishment after death. Five types of spiritual pain that seem to be frequent among patients facing death are discussed: 1. Loss of self-determination; 2. Loss of meaning; 3. Guilt feelings; 4. Loneliness and isolation; 5. Loss of hope. Three ways of preventing or reducing excessive fear of death and of lowering the various types of spiritual pain are suggested: 1. Death education; 2. Presence at the bedside; 3. Humor as an expression of love.

Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety

PubMed Central

Davis, Michael; Walker, David L; Miles, Leigh; Grillon, Christian

2010-01-01

Data will be reviewed using the acoustic startle reflex in rats and humans based on our attempts to operationally define fear vs anxiety. Although the symptoms of fear and anxiety are very similar, they also differ. Fear is a generally adaptive state of apprehension that begins rapidly and dissipates quickly once the threat is removed (phasic fear). Anxiety is elicited by less specific and less predictable threats, or by those that are physically or psychologically more distant. Thus, anxiety is a more long-lasting state of apprehension (sustained fear). Rodent studies suggest that phasic fear is mediated by the amygdala, which sends outputs to the hypothalamus and brainstem to produce symptoms of fear. Sustained fear is also mediated by the amygdala, which releases corticotropin-releasing factor, a stress hormone that acts on receptors in the bed nucleus of the stria terminalis (BNST), a part of the so-called ‘extended amygdala.' The amygdala and BNST send outputs to the same hypothalamic and brainstem targets to produce phasic and sustained fear, respectively. In rats, sustained fear is more sensitive to anxiolytic drugs. In humans, symptoms of clinical anxiety are better detected in sustained rather than phasic fear paradigms. PMID:19693004

Fear, pain and stress hormones during childbirth.

PubMed

Alehagen, Siw; Wijma, Barbro; Lundberg, Ulf; Wijma, Klaas

2005-09-01

To investigate the course of fear, pain and stress hormones during labor, and the associations between fear, pain, stress hormones and duration of labor in nulliparous women with and without epidural analgesia (EDA). One day during gestation weeks 37-39, urinary and salivary samples were collected to measure catecholamines and cortisol. Hourly during labor, the participants answered the Delivery Fear Scale and a pain intensity scale, and urinary and salivary samples were collected to measure stress hormones. The course of fear, pain and stress hormones differed throughout labor in women with and without EDA. Pain and cortisol increased throughout labor in women without EDA. Women who received EDA had more fear, but not more pain, before the administration of the EDA than women who did not receive EDA. Pain, fear and catecholamines decreased when women received EDA, but fear and pain increased again later in labor. Fear and pain correlated, as well as levels of fear in the different phases of labor. During phase one of labor epinephrine and duration of the phase were negatively correlated. The course of fear, pain and concentrations of stress hormones differed, highly influenced by the administration of EDA. Fear and pain correlated more pronounced than stress hormones and fear, pain and duration of labor.

Presence and process of fear of birth during pregnancy-Findings from a longitudinal cohort study.

PubMed

Hildingsson, Ingegerd; Haines, Helen; Karlström, Annika; Nystedt, Astrid

2017-10-01

The prevalence of fear of birth has been estimated between 8-30%, but there is considerable heterogeneity in research design, definitions, measurement tools used and populations. There are some inconclusive findings about the stability of childbirth fear. to assess the prevalence and characteristics of women presenting with scores ≥60 on FOBS-The Fear of Birth Scale, in mid and late pregnancy, and to study change in fear of birth and associated factors. A prospective longitudinal cohort study of a one-year cohort of 1212 pregnant women from a northern part of Sweden, recruited in mid pregnancy and followed up in late pregnancy. Fear of birth was assessed using FOBS-The fear of birth scale, with the cut off at ≥60. The prevalence of fear of birth was 22% in mid pregnancy and 19% in late pregnancy, a statistically significant decrease. Different patterns were found where some women presented with increased fear and some with decreased fear. The women who experienced more fear or less fear later in pregnancy could not be differentiated by background factors. More research is needed to explore factors important to reduce fear of childbirth and the optimal time to measure it. Copyright © 2017 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

Posterior insular cortex is necessary for conditioned inhibition of fear

PubMed Central

Foilb, Allison R.; Flyer-Adams, Johanna G.; Maier, Steven F.; Christianson, John P.

2016-01-01

Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS− fear discrimination conditioning over 5 days in rats leads the CS− to become a conditioned inhibitor of fear, as measured by the classic tests of conditioned inhibition: summation and retardation of subsequent fear acquisition. We then show that NMDA-receptor antagonist AP5 injected to posterior insular cortex (IC) before training completely prevented the acquisition of a conditioned fear inhibitor, while intra-AP5 to anterior and medial IC had no effect. To determine if the IC contributes to the recall of learned fear inhibition, injections of the GABAA agonist muscimol were made to posterior IC before a summation test. This resulted in fear inhibition per se, which obscured inference to the effect of IC inactivation with recall of the safety cue. Control experiments sought to determine if the role of the IC in conditioned inhibition learning could be reduced to simpler fear discrimination function, but fear discrimination and recall were unaffected by AP5 or muscmiol, respectively, in the posterior IC. These data implicate a role of posterior IC in the learning of conditioned fear inhibitors. PMID:27523750

From normal fear to pathological anxiety.

PubMed

Rosen, J B; Schulkin, J

1998-04-01

In this article the authors address how pathological anxiety may develop from adaptive fear states. Fear responses (e.g., freezing, startle, heart rate and blood pressure changes, and increased vigilance) are functionally adaptive behavioral and perceptual responses elicited during danger to facilitate appropriate defensive responses that can reduce danger or injury (e.g., escape and avoidance). Fear is a central motive state of action tendencies subserved by fear circuits, with the amygdala playing a central role. Pathological anxiety is conceptualized as an exaggerated fear state in which hyperexcitability of fear circuits that include the amygdala and extended amygdala (i.e., bed nucleus of the stria terminalis) is expressed as hypervigilance and increased behavioral responsivity to fearful stimuli. Reduced thresholds for activation and hyperexcitability in fear circuits develop through sensitization- or kindling-like processes that involve neuropeptides, hormones, and other proteins. Hyperexcitability in fear circuits is expressed as pathological anxiety that is manifested in the various anxiety disorders.

[Relationship between early maladaptive schemas, attachment quality and fear of darkness].

PubMed

Kopcsó, Krisztina; Láng, András

2014-12-07

Although fear of darkness is most common in childhood, it is also a remarkable phenomenon in young adulthood. To examine the relationship between fear of darkness, early maladaptive schemas and attachment quality in young adults and assess fear related sex differences. A self-developed scale was used to measure fear of darkness' intensity and frequency. Young Schema Questionnaire - Short Form and two scales that measure attachment dimensions were also applied. 120 university students (68 women, 52 men) filled in the tests. Fear of darkness' frequency correlated with avoidant attachment, and intensity with independent and anxious attachment. Fear of darkness variables correlated with several early maladaptive schemas. Women reported more frequent and intensive fear of darkness than men. These results indicated that the elevated level of fear of darkness is related to specific cognitive style and attachment quality. This highlights the potential clinical relevance of fear of darkness.

[How to properly use the fear in AIDS intervention-the history and further of fear appeal development].

PubMed

Zhang, Ke; Du, Xiufang; Tao, Xiaorun; Zhang, Yuanyuan; Kang, Dianmin

2015-08-01

The AIDS epidemic in men who have sex wlth men (MSM) in recent years showed a sharp upward trend, looking for behavioral intervention strategies should be imperative. Fear appeals by fear prompted intervention received intervention information, provide a new breakthrough to achieve better effect of propaganda and intervention. After over 70 years development, the Fear Appeal generated from the driver model that proposed the fear decided the effectiveness of behavior intervention, to the extended parallel process model theory which integrated protection motivation theory and parallel process theory, both of which believed the fear is just one of the estimators, suggested fear is the key factor. The fear appeal theory is turning to be even more comprehensive and accurate. As an important theoretical basement, the fear appeal is still developing, and need more work to make it perfection.

Hippocampal Processing of Ambiguity Enhances Fear Memory

PubMed Central

Amadi, Ugwechi; Lim, Seh Hong; Liu, Elizabeth; Baratta, Michael V.; Goosens, Ki Ann

2016-01-01

Despite the ubiquitous use of Pavlovian fear conditioning as a model for fear learning, the highly predictable conditions used in the laboratory do not resemble real-world conditions, where dangerous situations can lead to unpleasant outcomes in unpredictable ways. Here we varied the timing of aversive events following predictive cues in rodents and discovered that temporal ambiguity of aversive events greatly enhances fear. During fear conditioning with unpredictably timed aversive events, pharmacological inactivation of the dorsal hippocampus or optogenetic silencing of CA1 cells during aversive negative prediction errors prevented this enhancement of fear without impacting fear learning for predictable events. Dorsal hippocampal inactivation also prevented ambiguity-related enhancement of fear during auditory fear conditioning under a partial reinforcement schedule. These results reveal that information about the timing and occurrence of aversive events is rapidly acquired and that unexpectedly timed or omitted aversive events generate hippocampal signals to enhance fear learning. PMID:28182526

Gender role orientation and fearfulness in children with anxiety disorders.

PubMed

Ginsburg, G S; Silverman, W K

2000-01-01

Research on gender differences in children's fears has generally shown that girls are more fearful than boys. A common hypothesis offered for this finding is that gender role orientations or expectations may be operating. However, this hypothesis has not been directly investigated in child samples. The present study examined the relation between a self-report measure of gender role orientation (i.e., masculinity/femininity) and the intensity of self-reported fears in a clinic sample of children (N = 66; ages 6-11; 41 boys and 25 girls) with anxiety disorders. Results revealed that masculinity was negatively related to overall levels of fearfulness as well as specific fears of failure and criticism, medical fears, and fears of the unknown. In contrast, no relation was found between femininity and fearfulness. These findings suggest that gender role orientation, especially masculinity, may play a role in the development and/or maintenance of fearfulness in children.

Fear-relevant illusory correlations in different fears and anxiety disorders: A review of the literature.

PubMed

Wiemer, Julian; Pauli, Paul

2016-08-01

Fearful individuals often overestimate the relationship between fear-relevant stimuli and aversive consequences. Such fear-relevant illusory correlations (ICs) might be involved in the maintenance of anxiety disorders. In this literature review, we found clear evidence that ICs are present and enhanced in fear of animals. We also revealed some evidence for ICs related to fear of flying, social anxiety, contamination fear, panic disorder, and post-traumatic stress disorder, but with considerably less clarity. Fear-relevant ICs seem to be best explained by both a priori expectancies and biased encoding of the experienced associations. Studies to date suggest that one important biased encoding process is the enhanced aversiveness/salience of fear-relevant outcomes. Future studies may improve insight by developing more reliable IC measures and testing the effect of encoding processes on treatment outcomes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Toddlers’ dysregulated fear predicts delta-beta coupling during preschool

PubMed Central

Phelps, Randi A.; Brooker, Rebecca J.; Buss, Kristin A.

2015-01-01

Dysregulated fear, or the persistence of high levels of fear in low-threat contexts, is an early risk factor for the development of anxiety symptoms. Previous work has suggested both propensities for over-control and under-control of fearfulness as risk factors for anxiety problems, each of which may be relevant to observations of dysregulated fear. Given difficulty disentangling over-control and under-control through traditional behavioral measures, we used delta-beta coupling to begin to understand the degree to which dysregulated fear may reflect propensities for over- or under-control. We found that toddlers who showed high levels of dysregulated fear evidenced greater delta-beta coupling at frontal and central electrode sites as preschoolers relative to children who were low in dysregulated fear. Importantly, these differences were not observed when comparisons were made based on fear levels in high threat contexts. Results suggest dysregulated fear may involve tendencies toward over-control at the neural level. PMID:26624221

Hippocampal Processing of Ambiguity Enhances Fear Memory.

PubMed

Amadi, Ugwechi; Lim, Seh Hong; Liu, Elizabeth; Baratta, Michael V; Goosens, Ki A

2017-02-01

Despite the ubiquitous use of Pavlovian fear conditioning as a model for fear learning, the highly predictable conditions used in the laboratory do not resemble real-world conditions, in which dangerous situations can lead to unpleasant outcomes in unpredictable ways. In the current experiments, we varied the timing of aversive events after predictive cues in rodents and discovered that temporal ambiguity of aversive events greatly enhances fear. During fear conditioning with unpredictably timed aversive events, pharmacological inactivation of the dorsal hippocampus or optogenetic silencing of cornu ammonis 1 cells during aversive negative prediction errors prevented this enhancement of fear without affecting fear learning for predictable events. Dorsal hippocampal inactivation also prevented ambiguity-related enhancement of fear during auditory fear conditioning under a partial-reinforcement schedule. These results reveal that information about the timing and occurrence of aversive events is rapidly acquired and that unexpectedly timed or omitted aversive events generate hippocampal signals to enhance fear learning.

Implications of memory modulation for post-traumatic stress and fear disorders

PubMed Central

Parsons, Ryan G; Ressler, Kerry J

2013-01-01

Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Their development involves heredity, previous sensitizing experiences, association of aversive events with previous neutral stimuli, and inability to inhibit or extinguish fear after it is chronic and disabling. We highlight recent progress in fear learning and memory, differential susceptibility to disorders of fear, and how these findings are being applied to the understanding, treatment and possible prevention of fear disorders. Promising advances are being translated from basic science to the clinic, including approaches to distinguish risk versus resilience before trauma exposure, methods to interfere with fear development during memory consolidation after a trauma, and techniques to inhibit fear reconsolidation and to enhance extinction of chronic fear. It is hoped that this new knowledge will translate to more successful, neuroscientifically informed and rationally designed approaches to disorders of fear regulation. PMID:23354388

Instructed fear learning, extinction, and recall: additive effects of cognitive information on emotional learning of fear.

PubMed

Javanbakht, Arash; Duval, Elizabeth R; Cisneros, Maria E; Taylor, Stephan F; Kessler, Daniel; Liberzon, Israel

2017-08-01

The effects of instruction on learning of fear and safety are rarely studied. We aimed to examine the effects of cognitive information and experience on fear learning. Fourty healthy participants, randomly assigned to three groups, went through fear conditioning, extinction learning, and extinction recall with two conditioned stimuli (CS+). Information was presented about the presence or absence of conditioned stimulus-unconditioned stimulus (CS-US) contingency at different stages of the experiment. Information about the CS-US contingency prior to fear conditioning enhanced fear response and reduced extinction recall. Information about the absence of CS-US contingency promoted extinction learning and recall, while omission of this information prior to recall resulted in fear renewal. These findings indicate that contingency information can facilitate fear expression during fear learning, and can facilitate extinction learning and recall. Information seems to function as an element of the larger context in which conditioning occurs.

Oxytocin and Social Support as Synergistic Inhibitors of Aversive Fear Conditioning and Fear-Potentiated Startle in Male Rats

DTIC Science & Technology

2009-09-01

startle amplitude. They then received Pavlovian fear conditioning of five pairings of a 3 s light co-terminating with a 500 ms, 0.6mA footshock. Four...Synergistic Inhibitors of Aversive Fear Conditioning and Fear-Potentiated Startle in Male Rats PRINCIPAL INVESTIGATOR: Jeffrey B. Rosen, Ph.D...NUMBER Oxytocin and Social Support as Synergistic Inhibitors of Aversive Fear Conditioning and Fear-Potentiated Startle in Male Rats 5b. GRANT

Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Catechol Ring-Fluorinated CAPE Derivatives Against Menadione-Induced Oxidative Stress in Human Endothelial Cells

DTIC Science & Technology

2006-03-31

chlorogenic acid , and rosmari- nic acid did not display any cytoprotective effect in this assay at 15 lM (data not shown). Within the same pas- sage of HUVEC...Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative...accepted 13 March 2006 Available online 31 March 2006 Abstract—Caffeic acid phenethyl ester (CAPE), a natural polyphenolic compound with many

Cape Cod, MA, USA

NASA Technical Reports Server (NTRS)

1992-01-01

Cape Cod, (41.5N, 71.0W) is a very young geological feature, formed after the retreat of the last glaciers some 15,000 years ago. The cape is made up of outwash sands laid down by rivers of melt water from glaciers which pushed as far south as Long Island. The cape itself then lay many miles inland but as the glaciers melted, the water level of the world's oceans rose to their present level. Storm waves, wind and tides then formed the Cape Cod hook.

Early Social Fear Predicts Kindergarteners' Socially Anxious Behaviors: Direct Associations, Moderation by Inhibitory Control, and Differences from Nonsocial Fear

PubMed Central

Brooker, Rebecca J.; Kiel, Elizabeth J.; Buss, Kristin A.

2015-01-01

Although social and nonsocial fear are discernable as early as preschool, little is known about their distinct associations with developmental outcomes. For example, fear has been identified as a predictor of social anxiety problems, but no work has examined whether social and nonsocial fear make independent contributions to risk. We investigated the extent to which early social and non-social fear were associated with socially anxious behaviors during kindergarten. To do this, we identified distinct trajectories of social and nonsocial fear across toddlerhood and preschool. Only social fear was associated with socially anxious behaviors at ages 2 and 5. Because the ability to regulate fear contributes to the degree to which fearful children are at risk for anxiety problems, we also tested whether an early-developing aspect of self-regulation modulated associations between early fear and kindergarten socially anxious behaviors. Specifically, we tested whether inhibitory control differentially modulated associations between early levels of social and nonsocial fear and socially anxious behaviors during kindergarten. Associations between trajectories of early social fear and age 5 socially anxious behaviors were moderated by individual differences in inhibitory control. Consistent with previous research showing associations between overcontrol and anxiety symptoms, more negative outcomes were observed when stable, high levels of social fear across childhood were coupled with high levels of inhibitory control. Results suggest that the combination of social fear and overcontrol reflect a profile of early risk for the development of social inhibition and social anxiety problems. PMID:27213729

Fear-avoidance beliefs and parental responses to pain in adolescents with chronic pain.

PubMed

Wilson, Anna C; Lewandowski, Amy S; Palermo, Tonya M

2011-01-01

The fear-avoidance model of chronic pain posits that fear of pain is associated with fear and avoidance of activity, which can lead to deconditioning and persistence of pain and disability. Despite being well supported in adults, little is known about the role of fear-avoidance beliefs regarding physical activity in children. Research has shown that parental protectiveness contributes to activity limitations in children; however, no studies have examined relationships between protectiveness, and fear and avoidance. To conduct a cross-sectional study to provide additional information regarding the reliability and validity of the Fear-Avoidance Beliefs Questionnaire physical activity subscale among adolescents with chronic pain; examine fear-avoidance beliefs and depressive symptoms as concurrent predictors of physical activity limitations; and test competing models using fear-avoidance beliefs as mediators and moderators of the association between parental protectiveness and activity limitations. Adolescents (n=42) 11 to 17 years of age with chronic pain completed questionnaires assessing pain intensity, fear-avoidance beliefs, depressive symptoms and physical activity limitations. Their parents completed questionnaires regarding protectiveness and adolescent activity limitations. The Fear-Avoidance Beliefs Questionnaire physical activity subscale was useful for assessing fear-avoidance beliefs in the present population. In support of hypotheses, greater fear-avoidance beliefs were associated with greater activity limitations, above pain intensity and depressive symptoms. Support was found for fear-avoidance beliefs as mediators of the association between parental protectiveness and activity limitations. Tests of moderation were not significant. Fear-avoidance beliefs may be an important target for interventions focused on decreasing activity limitations in youth with chronic pain. Future research should investigate these associations longitudinally.

Amygdala upregulation of NCAM polysialylation induced by auditory fear conditioning is not required for memory formation, but plays a role in fear extinction.

PubMed

Markram, Kamila; Lopez Fernandez, Miguel Angel; Abrous, Djoher Nora; Sandi, Carmen

2007-05-01

There is much interest to understand the mechanisms leading to the establishment, maintenance, and extinction of fear memories. The amygdala has been critically involved in the processing of fear memories and a number of molecular changes have been implicated in this brain region in relation to fear learning. Although neural cell adhesion molecules (NCAMs) have been hypothesized to play a role, information available about their contribution to fear memories is scarce. We investigate here whether polysialylated NCAM (PSA-NCAM) contributes to auditory fear conditioning in the amygdala. First, PSA-NCAM expression was evaluated in different amygdala nuclei after auditory fear conditioning at two different shock intensities. Results showed that PSA-NCAM expression was increased 24 h post-training only in animals subjected to the highest shock intensity (1mA). Second, PSA-NCAM was cleaved in the basolateral amygdaloid complex through micro-infusions of the enzyme endoneuraminidase N, and the consequences of such treatment were investigated on the acquisition, consolidation, remote memory expression, and extinction of conditioned fear memories. Intra-amygdaloid cleavage of PSA-NCAM did not affect acquisition, consolidation or expression of remote fear memories. However, intra-amygdaloid PSA-NCAM cleavage enhanced fear extinction processes. These results suggest that upregulation of PSA-NCAM is a correlate of fear conditioning that is not necessary for the establishment of fear memory in the amygdala, but participates in mechanisms precluding fear extinction. These findings point out PSA-NCAM as a potential target for the treatment of psychopathologies that involve impairment in fear extinction.

NPY controls fear conditioning and fear extinction by combined action on Y₁ and Y₂ receptors.

PubMed

Verma, D; Tasan, R O; Herzog, H; Sperk, G

2012-06-01

Neuropeptide Y (NPY) and its receptors have been implicated in the control of emotional-affective processing, but the mechanism is unclear. While it is increasingly evident that stimulation of Y₁ and inhibition of Y₂ receptors produce prominent anxiolytic and antidepressant effects, the contribution of the individual NPY receptor subtypes in the acquisition and extinction of learned fear are unknown. Here we performed Pavlovian fear conditioning and extinction in NPY knockout (KO) and in NPY receptor KO mice. NPY KO mice display a dramatically accelerated acquisition of conditioned fear. Deletion of Y₁ receptors revealed only a moderately accelerated acquisition of conditioned fear, while lack of Y₂ receptors was without any effect on fear learning. However, the strong phenotype seen in NPY KO mice was reproduced in mice lacking both Y₁ and Y₂ receptors. In addition, NPY KO mice showed excessive recall of conditioned fear and impaired fear extinction. This behaviour was replicated only after deletion of both Y₁ and Y₂ receptors. In Y₁ receptor single KO mice, fear extinction was delayed and was unchanged in Y₂ receptor KO mice. Deletion of NPY and particularly Y₂ receptors resulted in a generalization of conditioned fear. Our data demonstrate that NPY delays the acquisition, reduces the expression of conditioned fear while promoting fear extinction. Although these effects appear to be primarily mediated by Y₁ receptors, the pronounced phenotype of Y₁Y₂ receptor double KO mice suggests a synergistic role of Y₂ receptors in fear acquisition and in fear extinction. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

A meta-analysis of fear appeals: implications for effective public health campaigns.

PubMed

Witte, K; Allen, M

2000-10-01

The fear appeal literature is examined in a comprehensive synthesis using meta-analytical techniques. The meta-analysis suggests that strong fear appeals produce high levels of perceived severity and susceptibility, and are more persuasive than low or weak fear appeals. The results also indicate that fear appeals motivate adaptive danger control actions such as message acceptance and maladaptive fear control actions such as defensive avoidance or reactance. It appears that strong fear appeals and high-efficacy messages produce the greatest behavior change, whereas strong fear appeals with low-efficacy messages produce the greatest levels of defensive responses. Future directions and practical implications are provided.

Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans

PubMed Central

Steinfurth, Elisa C.K.; Kanen, Jonathan W.; Raio, Candace M.; Clem, Roger L.; Huganir, Richard L.; Phelps, Elizabeth A.

2014-01-01

Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications. PMID:24934333

Dental Fear among Medical and Dental Undergraduates

PubMed Central

Hakim, H.; Razak, I. A.

2014-01-01

Objective. To assess the prevalence and level of dental fear among health related undergraduates and to identify factors causing such fear using Kleinknecht's Dental Fear Survey (DFS) questionnaire. Methods. Kleinknecht's DFS questionnaire was used to assess dental fear and anxiety among the entire enrollment of the medical and dental undergraduates' of the University of Malaya. Results. Overall response rate was 82.2%. Dental students reported higher prevalence of dental fear (96.0% versus 90.4%). However, most of the fear encountered among dental students was in the low fear category as compared to their medical counterpart (69.2 versus 51.2%). Significantly more medical students cancelled dental appointment due to fear compared to dental students (P = 0.004). “Heart beats faster” and “muscle being tensed” were the top two physiological responses experienced by the respondents. “Drill” and “anesthetic needle” were the most fear provoking objects among respondents of both faculties. Conclusion. Dental fear and anxiety are a common problem encountered among medical and dental undergraduates who represent future health care professionals. Also, high level of dental fear and anxiety leads to the avoidance of the dental services. PMID:25386615

Toward better assessment of tornado potential in typhoons: Significance of considering entrainment effects for CAPE

NASA Astrophysics Data System (ADS)

Sueki, Kenta; Niino, Hiroshi

2016-12-01

The characteristics of typhoons that spawned tornadoes (tornadic typhoons: TTs) in Japan from 1991 to 2013 were investigated by composite analysis using the Japanese 55 year Reanalysis and compared with those of typhoons that did not spawn tornadoes (nontornadic typhoons: NTs). We found that convective available potential energy (CAPE), which considers the effects of entrainment (entraining CAPE: E-CAPE), and storm-relative environmental helicity (SREH) are significantly large in the northeast quadrant of TTs where tornadoes frequently occur and that E-CAPE and SREH in that quadrant for TTs are larger than those for NTs. On the other hand, ordinary CAPE without entrainment does not account for the spatial distribution of tornado occurrences nor does it distinguish TTs from NTs. E-CAPE is sensitive to humidity in the midtroposphere; thus, it is effective for detecting a conditionally unstable layer up to about 550 hPa, which is distinctive of TTs.

Does fear extinction in the laboratory predict outcomes of exposure therapy? A treatment analog study.

PubMed

Forcadell, Eduard; Torrents-Rodas, David; Vervliet, Bram; Leiva, David; Tortella-Feliu, Miquel; Fullana, Miquel A

2017-11-01

Fear extinction models have a key role in our understanding of anxiety disorders and their treatment with exposure therapy. Here, we tested whether individual differences in fear extinction learning and fear extinction recall in the laboratory were associated with the outcomes of an exposure therapy analog (ETA). Fifty adults with fear of spiders participated in a two-day fear-learning paradigm assessing fear extinction learning and fear extinction recall, and then underwent a brief ETA. Correlational analyses indicated that enhanced extinction learning was associated with better ETA outcome. Our results partially support the idea that individual differences in fear extinction learning may be associated with exposure therapy outcome, but suggest that further research in this area is needed. Copyright © 2017 Elsevier B.V. All rights reserved.

Origins of common fears in South African children.

PubMed

Muris, Peter; du Plessis, Michelle; Loxton, Helene

2008-12-01

The present study examined the origins of common childhood fears within a South African context. Six-hundred-and-fifty-five 10- to 14-year-old children were given a brief fear list that helped them to identify their most intense fear and then completed a brief questionnaire for assessing the origins of fears that was based on Rachman's [Rachman, S. (1977). The conditioning theory of fear acquisition: A critical examination. Behaviour Research and Therapy, 15, 375-387; Rachman, S. (1991). Neoconditioning and the classical theory of fear acquisition. Clinical Psychology Review, 17, 47-67] three-pathways theory. More precisely, children were asked to report whether they had experienced conditioning, modeling, and negative information experiences in relation to their most feared stimulus or situation, and also had to indicate to what extent such experiences had actually played a role in the onset and/or intensification of their fears. Results showed that children most frequently reported indirect learning experiences (i.e., modeling and negative information) in relation to their fears, whereas conditioning was clearly less often mentioned. The majority of the children had no precise idea of how their fear had actually begun, but a substantial proportion of them reported various learning experiences in relation to the onset and intensification of fears. Significant cultural differences were not only observed in the prevalence of common fears, but also in the pathways reported for the origins of fears. The results are briefly discussed in terms of the living conditions of South African children from various cultural backgrounds.

A twin study of the genetics of fear conditioning.

PubMed

Hettema, John M; Annas, Peter; Neale, Michael C; Kendler, Kenneth S; Fredrikson, Mats

2003-07-01

Fear conditioning is a traditional model for the acquisition of fears and phobias. Studies of the genetic architecture of fear conditioning may inform gene-finding strategies for anxiety disorders. The objective of this study was to determine the genetic and environmental sources of individual differences in fear conditioning by means of a twin sample. Classic fear conditioning data were experimentally obtained from 173 same-sex twin pairs (90 monozygotic and 83 dizygotic). Sequences of evolutionary fear-relevant (snakes and spiders) and fear-irrelevant (circles and triangles) pictorial stimuli served as conditioned stimuli paired with a mild electric shock serving as the unconditioned stimulus. The outcome measure was the electrodermal skin conductance response. We applied structural equation modeling methods to the 3 conditioning phases of habituation, acquisition, and extinction to determine the extent to which genetic and environmental factors underlie individual variation in associative and nonassociative learning. All components of the fear conditioning process in humans demonstrated moderate heritability, in the range of 35% to 45%. Best-fitting multivariate models suggest that 2 sets of genes may underlie the trait of fear conditioning: one that most strongly affects nonassociative processes of habituation that also is shared with acquisition and extinction, and a second that appears related to associative fear conditioning processes. In addition, these data provide tentative evidence of differences in heritability based on the fear relevance of the stimuli. Genes represent a significant source of individual variation in the habituation, acquisition, and extinction of fears, and genetic effects specific to fear conditioning are involved.

Glucocorticoids reduce phobic fear in humans

PubMed Central

Soravia, Leila M.; Heinrichs, Markus; Aerni, Amanda; Maroni, Caroline; Schelling, Gustav; Ehlert, Ulrike; Roozendaal, Benno; de Quervain, Dominique J.-F.

2006-01-01

Phobias are characterized by excessive fear, cued by the presence or anticipation of a fearful situation. Whereas it is well established that glucocorticoids are released in fearful situations, it is not known whether these hormones, in turn, modulate perceived fear. As extensive evidence indicates that elevated glucocorticoid levels impair the retrieval of emotionally arousing information, they might also inhibit retrieval of fear memory associated with phobia and, thereby, reduce phobic fear. Here, we investigated whether acutely administrated glucocorticoids reduced phobic fear in two double-blind, placebo-controlled studies in 40 subjects with social phobia and 20 subjects with spider phobia. In the social phobia study, cortisone (25 mg) administered orally 1 h before a socio-evaluative stressor significantly reduced self-reported fear during the anticipation, exposure, and recovery phase of the stressor. Moreover, the stress-induced release of cortisol in placebo-treated subjects correlated negatively with fear ratings, suggesting that endogenously released cortisol in the context of a phobic situation buffers fear symptoms. In the spider phobia study, repeated oral administration of cortisol (10 mg), but not placebo, 1 h before exposure to a spider photograph induced a progressive reduction of stimulus-induced fear. This effect was maintained when subjects were exposed to the stimulus again 2 days after the last cortisol administration, suggesting that cortisol may also have facilitated the extinction of phobic fear. Cortisol treatment did not reduce general, phobia-unrelated anxiety. In conclusion, the present findings in two distinct types of phobias indicate that glucocorticoid administration reduces phobic fear. PMID:16567641

77 FR 9699 - Cape Cod National Seashore Advisory Commission; Cape Cod National Seashore, South Wellfleet, MA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... DEPARTMENT OF THE INTERIOR National Park Service [1730-SZM] Cape Cod National Seashore Advisory Commission; Cape Cod National Seashore, South Wellfleet, MA AGENCY: National Park Service, Interior. ACTION... National Seashore, 99 Marconi Site Road, Wellfleet, MA 02667. Date: February 7, 2012. George E. Price, Jr...

77 FR 22611 - Cape Cod National Seashore Advisory Commission; Cape Cod National Seashore, South Wellfleet, MA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... DEPARTMENT OF THE INTERIOR National Park Service [1730-SZM] Cape Cod National Seashore Advisory Commission; Cape Cod National Seashore, South Wellfleet, MA AGENCY: National Park Service, Interior. ACTION... Cod National Seashore, 99 Marconi Site Road, Wellfleet, MA 02667. Dated: April 9, 2012. George E...

Nho Lobo: Folk Tales of the Cape Verdean People. Teacher's Guide.

ERIC Educational Resources Information Center

Nyhan, Patricia; Almeida, Raymond A.

The teacher's guide presents two Cape Verdean folktales, background information, discussion questions, and activity suggestions for grades 4-6. The objective is to teach students about Cape Verde and its culture through folklore. The guide contains five sections. Section I offers a description of Cape Verdean folklore, describes five ways folklore…

Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester.

PubMed

Lim, Kyung-Min; Bae, SeungJin; Koo, Jung Eun; Kim, Eun-Sun; Bae, Ok-Nam; Lee, Joo Young

2015-04-01

Skin inflammation plays a central role in the pathophysiology and symptoms of diverse chronic skin diseases including atopic dermatitis (AD). In this study, we examined if caffeic acid phenethyl ester (CAPE), a skin-permeable bioactive compound from propolis, was protective against skin inflammation using in vitro cell system and in vivo animal disease models. CAPE suppressed TNF-α-induced NF-κB activation and expression of inflammatory cytokines in human keratinocytes (HaCaT). The potency and efficacy of CAPE were superior to those of a non-phenethyl derivative, caffeic acid. Consistently, topical treatment of CAPE (0.5 %) attenuated 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced skin inflammation on mouse ear as CAPE reduced ear swelling and histologic inflammation scores. CAPE suppressed increased expression of pro-inflammatory molecules such as TNF-α, cyclooxygenase-2 and inducible NO synthase in TPA-stimulated skin. TPA-induced phosphorylation of IκB and ERK was blocked by CAPE suggesting that protective effects of CAPE on skin inflammation is attributed to inhibition of NF-κB activation. Most importantly, in an oxazolone-induced chronic dermatitis model, topical application of CAPE (0.5 and 1 %) was effective in alleviating AD-like symptoms such as increases of trans-epidermal water loss, skin thickening and serum IgE as well as histologic inflammation assessment. Collectively, our results propose CAPE as a promising candidate for a novel topical drug for skin inflammatory diseases.

Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays

PubMed Central

Elnager, Abuzar; Hassan, Rosline; Idris, Zamzuri; Mustafa, Zulkifli; Wan-Arfah, Nadiah; Sulaiman, S. A.; Gan, Siew Hua; Abdullah, Wan Zaidah

2015-01-01

Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods. Standardized human whole blood (WB) clots were incubated in either blank controls or different concentrations of CAPE (3.75, 7.50, 15.00, 22.50, and 30.00 mM). After 3 hours, D-dimer (DD) levels and WB clot weights were measured for each concentration. Thromboelastography (TEG) parameters were recorded following CAPE incubation, and fibrin morphology was examined under a confocal microscope. Results. Overall, mean DD (μg/mL) levels were significantly different across samples incubated with different CAPE concentrations, and the median pre- and postincubation WB clot weights (grams) were significantly decreased for each CAPE concentration. Fibrin removal was observed microscopically and indicated dose-dependent effects. Based on the TEG test, the Ly30 fibrinolytic parameter was significantly different between samples incubated with two different CAPE concentrations (15.0 and 22.50 mM). The 50% effective dose (ED50) of CAPE (based on DD) was 1.99 mg/mL. Conclusions. This study suggests that CAPE possesses fibrinolytic activity following in vitro incubation and that it has dose-dependent activities. Therefore, further investigation into CAPE as a potential alternative thrombolytic agent should be conducted. PMID:25664321

Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear.

PubMed

Jiang, Lizhu; Mao, Rongrong; Tong, Jianbin; Li, Jinnan; Chai, Anping; Zhou, Qixin; Yang, Yuexiong; Wang, Liping; Li, Lingjiang; Xu, Lin

2016-10-01

Promoting extinction of fear memory is the main treatment of fear disorders, especially post-traumatic stress disorder (PTSD). However, fear extinction is often incomplete in these patients. Our previous study had shown that Rac1 activity in hippocampus plays a crucial role in the learning of contextual fear memory in rats. Here, we further investigated whether Rac1 activity also modulated the extinction of contextual fear memory. We found that massed extinction obviously upregulated hippocampal Rac1 activity and induced long-term extinction of contextual fear in rats. Intrahippocampal injection of the Rac1 inhibitor NSC23766 prevents extinction of contextual fear in massed extinction training rats. In contrast, long-spaced extinction downregulated Rac1 activity and caused less extinction. And Rac1 activator CN04-A promotes extinction of contextual fear in long-spaced extinction rats. Our study demonstrates that inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear, suggesting that modulating Rac1 activity of the hippocampus may be promising therapy of fear disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

Contextual and Auditory Fear Conditioning Continue to Emerge during the Periweaning Period in Rats

PubMed Central

Burman, Michael A.; Erickson, Kristen J.; Deal, Alex L.; Jacobson, Rose E.

2014-01-01

Anxiety disorders often emerge during childhood. Rodent models using classical fear conditioning have shown that different types of fear depend upon different neural structures and may emerge at different stages of development. For example, some work has suggested that contextual fear conditioning generally emerges later in development (postnatal day 23–24) than explicitly cued fear conditioning (postnatal day 15–17) in rats. This has been attributed to an inability of younger subjects to form a representation of the context due to an immature hippocampus. However, evidence that contextual fear can be observed in postnatal day 17 subjects and that cued fear conditioning continues to emerge past this age raises questions about the nature of this deficit. The current studies examine this question using both the context pre-exposure facilitation effect for immediate single-shock contextual fear conditioning and traditional cued fear conditioning using Sprague-Dawley rats. The data suggest that both cued and contextual fear conditioning are continuing to develop between PD 17 and 24, consistent with development occurring the in essential fear conditioning circuit. PMID:24977415

The fears, phobias and anxieties of children with autism spectrum disorders and Down syndrome: comparisons with developmentally and chronologically age matched children.

PubMed

Evans, David W; Canavera, Kristin; Kleinpeter, F Lee; Maccubbin, Elise; Taga, Ken

2005-01-01

This study compared the fears and behavior problems of 25 children with an autism spectrum disorder (ASD), 43 children with Down syndrome (DS), 45 mental age (MA) matched children, and 37 chronologically age (CA) matched children. Children's fears, phobias, anxieties and behavioral problems were assessed using parent reports. Significant differences emerged across the diagnostic groups on a variety of fears. Children with ASD were reported to have more situation phobias and medical fears, but fewer fears of harm/injury compared to all other groups. The groups also differed in terms of the pattern of correlations between fears, phobias, anxieties and behavior problems. For children with ASD, fears, phobias and anxieties were closely related to problem behaviors, whereas fears, phobias, and anxieties were less related to behavioral symptoms for the other groups of subjects. Such findings suggest that children with ASD exhibit a distinct profile of fear and anxiety compared to other mental age and chronologically age-matched children, and these fears are related to the symptoms associated with ASD.

Psychiatry between Glorification and Stigmatization.

PubMed

Sutovic, Alija

2017-12-01

In psychiatry, stigma means negative marking of the person only because s(he) has a diagnosis of mental disease, and usually this refers to schizophrenia. Stigmatization is related to prejudice, i.e. negative attitudes that are deeply rooted on false beliefs that schizophrenia cannot be treated. In principle, stigma is caused by combination of ignorance and fear which represents the basis of the creation of entrenched myths and prejudice. From a historical point of view, schizophrenia as a disease remains for public, one of the medical areas that are related to fear, a sense of discomfort, prejudice and avoidance. A combination of difficult mental disease, discrimination and stigmatization can be devastating for mentally disabled patients. Throughout history, stigma played significant role in patient's emotional and social isolation from other people deepening their suffering. A common consequence of stigma is discrimination which represents violation of basic human rights. Mentally disabled patients are often unjustifiably seen as dangerous, incapable, irresponsible which causes their isolation, homelessness and economic collapse. Thereby, possibilities for normal life, work, treatment, rehabilitation and social integration are decreased.

Worry-inducing stimuli in an aversive Go/NoGo task enhance reactive control in individuals with lower trait-anxiety.

PubMed

Leue, Anja; Rodilla, Carmen Cano; Beauducel, André

2017-04-01

This study relates predictions on reactive and proactive cognitive control to findings on anxious apprehension/worry and ERN/Ne. We investigated whether worry-inducing stimuli in an aversive performance setting lead to a more pronounced increase of the ERN/Ne in individuals with lower anxious apprehension/worry. We also explored the N2 amplitude in the context of worry-inducing stimuli. Fifty-eight participants performed an extended Go/NoGo task. A neutral or fearful face was presented at the beginning of each trial, with the fearful face as a worry-inducing, distracting stimulus. In an aversive feedback condition, aversive feedback was provided for false or too slow responses. We found a more pronounced decrease of the ERN/Ne after worry-inducing stimuli compared to neutral stimuli in participants with lower anxious apprehension/worry. Moreover, less pronounced N2 amplitudes were associated with shorter reaction times in the aversive feedback condition. Implications for future research on error monitoring and trait-anxiety are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells.

PubMed

Duan, Jianhui; Xiaokaiti, Yilixiati; Fan, Shengjun; Pan, Yan; Li, Xin; Li, Xuejun

2017-05-01

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors of the digestive system, but the mechanisms of its development and progression are unclear. Inflammation is thought to be fundamental to pancreatic cancer development and caffeic acid phenethyl ester (CAPE) is an active component of honey bee resin or propolis with anti-inflammatory and anticancer activities. We investigated the inhibitory effects of CAPE on cell growth and migration induced by human neutrophil elastase (HNE) and report that HNE induced cancer cell migration at low doses and growth at higher doses. In contrast, lower CAPE doses inhibited migration and higher doses of CAPE inhibited the growth induced by HNE. HNE activity was significantly inhibited by CAPE (7.5-120 µM). Using quantitative real-time PCR and western blotting, we observed that CAPE (18-60 µM) did not affect transcription and translation of α1-antitrypsin (α1-AT), an endogenous HNE inhibitor. However, in an in silico drug target docking model, we found that CAPE directly bound to the binding pocket of HNE (25.66 kcal/mol) according to CDOCKER, and the residue of the catalytic site stabilized the interaction between CAPE and HNE as evidenced by molecular dynamic simulation. Response unit (RU) values of surface plasmon resonance (SPR) significantly increased with incremental CAPE doses (7.5-120 µM), indicating that CAPE could directly bind to HNE in a concentration-dependent manner. Thus, CAPE is an effective inhibitor of HNE via direct interaction whereby it inhibits the migration and growth of PANC-1 cells in a dose-dependent manner.

Reliability and Validity of the Turkish Version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V).

PubMed

Özcebe, Esra; Aydinli, Fatma Esen; Tiğrak, Tuğçe Karahan; İncebay, Önal; Yilmaz, Taner

2018-01-11

The main purpose of this study was to culturally adapt the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) to Turkish and to evaluate its internal consistency, validity, and reliability. The Turkish version of CAPE-V was developed, and with the use of a prospective case-control design, the voice recordings of 130 participants were collected according to CAPE-V protocol. Auditory-perceptual evaluation was conducted according to CAPE-V and Grade, Roughness, Breathiness, Asthenia, and Strain (GRBAS) scale by two ear, nose, and throat specialists and two speech and language therapists. The different types of voice disorders, classified as organic and functional disorders, were compared in terms of their CAPE-V scores. The overall severity parameter had the highest intrarater and inter-reliability values for all the participants. For all four raters, the differences in the six CAPE-V parameters between the study and the control groups were found to be statistically significant. Among the correlations for the comparable parameters of the CAPE-V and the GRBAS scales, the highest correlation was found between the overall severity-grade parameters. There was no difference found between the organic and functional voice disorders in terms of the CAPE-V scores. The Turkish version of CAPE-V has been proven to be a reliable and valid instrument to use in the auditory-perceptual evaluation of voice. For the future application of this study, it would be important to investigate whether cepstral measures correlate with the auditory-perceptual judgments of dysphonia severity collected by a Turkish version of the CAPE-V. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells.

PubMed

Sonoki, Hiroyuki; Tanimae, Asami; Furuta, Takumi; Endo, Satoshi; Matsunaga, Toshiyuki; Ichihara, Kenji; Ikari, Akira

2018-06-01

Claudin-2 is highly expressed in human lung adenocarcinoma cells and involved in the promotion of proliferation. Here, we searched for a compound, which can decrease claudin-2 expression using lung adenocarcinoma A549 cells. In the screening using compounds included in royal jelly and propolis, the protein level of claudin-2 was dose-dependently decreased by caffeic acid phenethyl ester (CAPE), whereas the mRNA level and promoter activity were only decreased by 50 μM CAPE. These results suggest that CAPE down-regulates claudin-2 expression mediated by two different mechanisms. CAPE (50 μM) decreased the level of p-NF-κB, whereas it increased that of IκB. The CAPE-induced decrease in promoter activity of claudin-2 was blocked by the mutation in an NF-κB-binding site. The inhibition of NF-κB may be involved in the decrease in mRNA level of claudin-2. The CAPE (10 μM)-induced decrease in claudin-2 expression was inhibited by chloroquine, a lysosomal inhibitor. CAPE increased the expression and activity of protein phosphatase (PP) 1 and 2A. The CAPE-induced decrease in claudin-2 expression was blocked by cantharidin, a potent PPs inhibitor. The cell proliferation was suppressed by CAPE, which was partially rescued by ectopic expression of claudin-2. In addition, the toxicity and accumulation of doxorubicin in 3D spheroid cells were enhanced by CAPE, which was inhibited by ectopic expression of claudin-2. Taken together, CAPE down-regulates claudin-2 expression at the transcriptional and post-translational levels, and enhances sensitivity of cells to doxorubicin in 3D culture conditions. CAPE may be a useful adjunctive compound in the treatment of lung adenocarcinoma. Copyright © 2018 Elsevier Inc. All rights reserved.

Caffeic acid phenethyl ester protects against glucocorticoid-induced osteoporosis in vivo: Impact on oxidative stress and RANKL/OPG signals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tolba, Mai F.

Glucocorticoid-induced osteoporosis (GIO) is one of the most common causes of secondary osteoporosis. Given that glucocorticoids are considered as a main component of the treatment protocols for a variety of inflammation and immune-mediated diseases besides its use as adjuvant to several chemotherapeutic agents, it is crucial to find ways to overcome this critical adverse effect. Caffeic acid phenethyl ester (CAPE), which is a natural compound derived from honeybee propolis displayed promising antiosteoporotic effects against mechanical bone injury in various studies. The current work aimed at investigating the potential protective effect of CAPE against GIO in vivo with emphasis on themore » modulation of oxidative status and receptor activator of NF-kB ligand (RANKL)/osteoprotegrin (OPG) signaling. The results showed that CAPE opposed dexamethasone (DEX)-mediated alterations in bone histology and tartarate-resistant acid phosphatase (TRAP) activity. In addition, CAPE restored oxidative balance, Runt-related transcription factor 2 (RunX2) expression and reduced caspase-3 activity in femur tissues. Co-administration of CAPE with DEX normalized RANKL/OPG ratio and Akt activation indicating a reduction in DEX-osteoclastogenesis. In conclusion, concurrent treatment of CAPE with DEX exhibited promising effects in the protection against DEX-induced osteoporosis through opposing osteoclastogenesis and protecting osteoblasts. The potent antioxidant activity of CAPE is, at least in part, involved in its anti-apoptotic effects and modulation of RunX2 and RANKL/OPG signals. The use of CAPE-enriched propolis formulas is strongly recommended for patients on chronic glucocorticoid therapy to help in the attenuation of GIO. - Highlights: • Caffeic acid phenethyl ester (CAPE) counteracts DEX-induced osteoporosis. • CAPE hinders DEX-induced alterations in oxidation parameters as GSH, SOD and MDA. • CAPE opposes osteoclastogenesis via suppressing RANL/OPG ratio and Akt signals. • CAPE supports the osteoblasts via modulating caspase-3 and RUNX2 signals.« less

Acute Exercise Enhances the Consolidation of Fear Extinction Memory and Reduces Conditioned Fear Relapse in a Sex-Dependent Manner

ERIC Educational Resources Information Center

Bouchet, Courtney A.; Lloyd, Brian A.; Loetz, Esteban C.; Farmer, Caroline E.; Ostrovskyy, Mykola; Haddad, Natalie; Foright, Rebecca M.; Greenwood, Benjamin N.

2017-01-01

Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can…

A Latent Growth Examination of Fear Development in Infancy: Contributions of Maternal Depression and the Risk for Toddler Anxiety

ERIC Educational Resources Information Center

Gartstein, Maria A.; Bridgett, David J.; Rothbart, Mary K.; Robertson, Christopher; Iddins, Erin; Ramsay, Kristin; Schlect, Sarah

2010-01-01

Growth modeling was used to examine the developmental trajectory of infant temperamental fear with maternal fear and depressive symptoms as predictors of infant fearfulness and change in infant fear predicting toddler anxiety symptoms. In Study 1, a sample of 158 mothers reported their own depressive symptoms and fear when their children were 4…

Maternal Modeling and the Acquisition of Fear and Avoidance in Toddlers: Influence of Stimulus Preparedness and Child Temperament

ERIC Educational Resources Information Center

Dubi, Kathrin; Rapee, Ronald M.; Emerton, Jane L.; Schniering, Carolyn A.

2008-01-01

The aim of the present study was to investigate the influence of maternal modeling on the acquisition of fear and avoidance towards fear-relevant and fear-irrelevant, novel stimuli in a sample of 71 toddlers. Children were shown a rubber snake or spider (fear-relevant objects) and a rubber mushroom or flower (fear-irrelevant objects), which were…

Differences in the Fears of Elementary School Children in North and South America: A Cross-Cultural Comparison

ERIC Educational Resources Information Center

Burnham, Joy J.; Hooper, Lisa M.; Ogorchock, Heather N.

2011-01-01

This study compared the fears of North American and South American children in Grades 2-5. Fears were assessed with English and Spanish versions of the American Fear Survey Schedule (FSSC-AM; Burnham 2005). Specific fears and several most common fears differed across the two countries. Overall, the South American children and the girls from both…

Remembering the object you fear: brain potentials during recognition of spiders in spider-fearful individuals.

PubMed

Michalowski, Jaroslaw M; Weymar, Mathias; Hamm, Alfons O

2014-01-01

In the present study we investigated long-term memory for unpleasant, neutral and spider pictures in 15 spider-fearful and 15 non-fearful control individuals using behavioral and electrophysiological measures. During the initial (incidental) encoding, pictures were passively viewed in three separate blocks and were subsequently rated for valence and arousal. A recognition memory task was performed one week later in which old and new unpleasant, neutral and spider pictures were presented. Replicating previous results, we found enhanced memory performance and higher confidence ratings for unpleasant when compared to neutral materials in both animal fearful individuals and controls. When compared to controls high animal fearful individuals also showed a tendency towards better memory accuracy and significantly higher confidence during recognition of spider pictures, suggesting that memory of objects prompting specific fear is also facilitated in fearful individuals. In line, spider-fearful but not control participants responded with larger ERP positivity for correctly recognized old when compared to correctly rejected new spider pictures, thus showing the same effects in the neural signature of emotional memory for feared objects that were already discovered for other emotional materials. The increased fear memory for phobic materials observed in the present study in spider-fearful individuals might result in an enhanced fear response and reinforce negative beliefs aggravating anxiety symptomatology and hindering recovery.

Effects of chemogenetic excitation or inhibition of the ventrolateral periaqueductal gray on the acquisition and extinction of Pavlovian fear conditioning.

PubMed

Arico, Carolyn; Bagley, Elena E; Carrive, Pascal; Assareh, Neda; McNally, Gavan P

2017-10-01

The midbrain periaqueductal gray (PAG) has been implicated in the generation and transmission of a prediction error signal that instructs amygdala-based fear and extinction learning. However, the PAG also plays a key role in the expression of conditioned fear responses. The evidence for a role of the PAG in fear learning and extinction learning has been obtained almost exclusively using PAG-dependent fear responses. It is less clear whether the PAG regulates fear learning when other measures of learned fear are used. Here we combined a chemogenetic approach, permitting excitation or inhibition of neurons in the ventrolateral PAG (VLPAG), with conditioned suppression as the measure of learned fear to assess the role of VLPAG in the acquisition and extinction of fear learning. We show that chemogenetic excitation of VLPAG (with some encroachment on lateral PAG [LPAG]) impairs acquisition of fear and, conversely, chemogenetic inhibition impairs extinction of fear. These effects on fear and extinction learning were specific to the combination of DREADD expression and injection of CNO because they were observed relative to both eYFP controls injected with CNO as well as DREADD expressing controls injected with vehicle. Taken together, these results show that activity of L/VLPAG neurons regulates both the acquisition and extinction of Pavlovian fear learning. Copyright © 2017 Elsevier Inc. All rights reserved.

Predicting the fear of assault at school and while going to and from school in an adolescent population.

PubMed

Alvarez, A; Bachman, R

1997-01-01

Recent research investigating the fear of crime has shown that when crime and behavior-specific measures of fear are utilized, the young are more likely than the elderly to be the most fearful. Research investigating the etiology of fear within adolescent populations, however, remains very limited. Using a sample of over 10,000 junior high and high school students from a supplement to the National Crime Victimization Survey, this paper examines the factors contributing to students' fear of assault both at school and while going to and from school. Results indicate that recent victimization experiences, the presence of a violent subculture at the school (e.g., gang presence and attacks on teachers) and availability of drugs/alcohol were related to fear in both contexts. The predictability of fear from individual characteristics, however, was context specific. Contrary to findings from earlier research, it was found that young females were not more fearful than their male counterparts in all contexts. While they were more fearful of an attack while going to and from school, there were no differences in fear levels while at school between males and females after controlling for other environmental and experiential factors. Conclusions largely support the contention that fear is a rational calculation based on objective criteria. Moreover, results underscore the need for more specificity when operationalizing the context and content of fearfulness.

Individual changes in dental fear among children and parents: a longitudinal study.

PubMed

Luoto, Anni; Tolvanen, Mimmi; Rantavuori, Kari; Pohjola, Vesa; Karlsson, Linnea; Lahti, Satu

2014-11-01

The aim was to study longitudinal changes in dental fear among children and one of their parents separately for girls, boys, mothers and fathers over a 3.5-year period. 11-12-year-old children in Pori, Finland (n = 1691) and one of their parents were invited to participate in this longitudinal study. Dental fear was measured in 2001, 2003 and 2005 when the children were 11-12, 13-14 and 15-16-years-old, respectively. The participants were asked if they were afraid of dental care (1 = 'not afraid', 2 = 'slightly afraid', 3 = 'afraid to some degree', 4 = 'quite afraid', 5 = 'very afraid' and 6 = 'I don't know'). The participants' gender was also registered. Mean values of the change scores were studied. Prevalence and incidence of dental fear and changes in dichotomized dental fear (responses 4-5 = high dental fear and responses 1-3 = low dental fear) were studied using cross-tabulations and Cochran's Q test. Overall, the prevalence of dental fear slightly increased and female preponderance in dental fear became more evident during the follow-up. Of the mothers and children with high dental fear at the baseline, 24% and 56%, respectively, reported not to be fearful at the end of the follow-up. Dental fear seems to be more stable in adulthood than in childhood. Thus, it might be better to intervene in dental fear during childhood rather than during adulthood.

Emotional contagion of dental fear to children: the fathers' mediating role in parental transfer of fear.

PubMed

Lara, America; Crego, Antonio; Romero-Maroto, Martin

2012-09-01

Dental fear is considered to be one of the most frequent problems in paediatric dentistry. According to literature, parents' levels of dental fear play a key role in the development of child's dental anxiety. HYPOTHESIS OR AIM: We have tried to identify the presence of emotional transmission of dental fear among family members and to analyse the different roles that mothers and fathers might play concerning the contagion of dental fear to children. We have hypothesized a key role of the father in the transfer of dental fear from mother to child. A questionnaire-based survey (Children's Fear Survey Schedule-Dental Subscale) has been distributed among 183 schoolchildren and their parents in Madrid (Spain). Inferential statistical analyses, i.e. correlation and hierarchical multiple regression, were carried out and possible mediating effects between variables have been tested. Our results support the hypothesis that family members' levels of dental fear are significantly correlated, and they also allow us to affirm that fathers' dental fear is a mediating variable in the relationship between mothers and children's fear scores. Together with the presence of emotional transmission of dental fear among family members, we identified the relevant role that fathers play as regards the transfer of dental fear from parents to children. © 2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd.

Posterior insular cortex is necessary for conditioned inhibition of fear.

PubMed

Foilb, Allison R; Flyer-Adams, Johanna G; Maier, Steven F; Christianson, John P

2016-10-01

Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in rats leads the CS- to become a conditioned inhibitor of fear, as measured by the classic tests of conditioned inhibition: summation and retardation of subsequent fear acquisition. We then show that NMDA-receptor antagonist AP5 injected to posterior insular cortex (IC) before training completely prevented the acquisition of a conditioned fear inhibitor, while intra-AP5 to anterior and medial IC had no effect. To determine if the IC contributes to the recall of learned fear inhibition, injections of the GABAA agonist muscimol were made to posterior IC before a summation test. This resulted in fear inhibition per se, which obscured inference to the effect of IC inactivation with recall of the safety cue. Control experiments sought to determine if the role of the IC in conditioned inhibition learning could be reduced to simpler fear discrimination function, but fear discrimination and recall were unaffected by AP5 or muscimol, respectively, in the posterior IC. These data implicate a role of posterior IC in the learning of conditioned fear inhibitors. Copyright © 2016 Elsevier Inc. All rights reserved.

The Set of Fear Inducing Pictures (SFIP): Development and validation in fearful and nonfearful individuals.

PubMed

Michałowski, Jarosław M; Droździel, Dawid; Matuszewski, Jacek; Koziejowski, Wojtek; Jednoróg, Katarzyna; Marchewka, Artur

2017-08-01

Emotionally charged pictorial materials are frequently used in phobia research, but no existing standardized picture database is dedicated to the study of different phobias. The present work describes the results of two independent studies through which we sought to develop and validate this type of database-a Set of Fear Inducing Pictures (SFIP). In Study 1, 270 fear-relevant and 130 neutral stimuli were rated for fear, arousal, and valence by four groups of participants; small-animal (N = 34), blood/injection (N = 26), social-fearful (N = 35), and nonfearful participants (N = 22). The results from Study 1 were employed to develop the final version of the SFIP, which includes fear-relevant images of social exposure (N = 40), blood/injection (N = 80), spiders/bugs (N = 80), and angry faces (N = 30), as well as 726 neutral photographs. In Study 2, we aimed to validate the SFIP in a sample of spider, blood/injection, social-fearful, and control individuals (N = 66). The fear-relevant images were rated as being more unpleasant and led to greater fear and arousal in fearful than in nonfearful individuals. The fear images differentiated between the three fear groups in the expected directions. Overall, the present findings provide evidence for the high validity of the SFIP and confirm that the set may be successfully used in phobia research.

Hurricane Isabel

NASA Image and Video Library

2003-09-18

This false-color image shows Hurricane Isabel viewed by the AIRS and AMSU-A instruments at 1:30 EDT in the morning of Thursday September 18, 2003. Isabel will be ashore within 12 hours, bringing widespread flooding and destructive winds. In figure 1 on the left, data retrieved by the AIRS infrared sensor shows the hurricane's eye as the small ring of pale blue near the upper left corner of the image. The dark blue band around the eye shows the cold tops of hundreds of powerful thunderstorms. These storms are embedded in the 120 mile per hour winds swirling counterclockwise around Isabel's eye. Cape Hatteras is the finger of land north-northwest of the eye. Isabel's winds will soon push ashore a 4- to 8-foot high mound of 'storm surge' and accompanying high surf, leading to flooding of Cape Hatteras and other islands of North Carolina's Outer Banks. Also seen in the image are several organized bands of cold, (blue) thunderstorm tops being pulled into the storm center. Other thunderstorm are forming north of the islands of Jamaica, Cuba, Hispaniola and Puerto Rico near the bottom of the picture. http://photojournal.jpl.nasa.gov/catalog/PIA00428

The Topological Properties of Stimuli Influence Fear Generalization and Extinction in Humans

PubMed Central

Xu, Liang; Su, Hongyu; Xie, Xiaoyuan; Yan, Pei; Li, Junjiao; Zheng, Xifu

2018-01-01

Fear generalization is an etiologically significant indicator of anxiety disorders, and understanding how to inhibit it is important in their treatment. Prior studies have found that reducing fear generalization using a generalization stimulus (GS) is ineffective in removing a conditioned fear that incorporates local features, and that topological properties appear to play a comparatively more significant role in the processes of perception and categorization. Our study utilized a conditioned-fear generalization design to examine whether the topological properties of stimuli influence the generalization and return of fear. Fear was indexed using online expectancy ratings and skin conductance responses (SCRs). The study’s 52 participants were divided into three groups: Group 1, conditioned danger cue (CS+) extinction; Group 2, extinction of one GS; Group 3, extinction of three GSs. We found that the three groups acquired conditioned fear at the same level. In the generalization and extinction phase, fear was transferred to the GS with the same topological properties as CS+, and gradual decreases in both shock expectancy and SCRs over non-reinforced extinction trials were observed. In the test phase, participants’ online expectancy ratings indicated that fear did not return in Group 1, but did return in Groups 2 and 3. All three groups demonstrated successful GS fear extinction, but only Group 1 did not show a return of fear for CS+. Regarding SCRs results, none of the groups demonstrated a return of fear, suggesting that utilization of topological properties successfully reduced the return of conditioned fear. Our results indicate that, in clinical settings, using GS with topological equivalence to CS+ might offer a potential method with which to extinct conditioned fear. PMID:29643824

A model of the generation of ataque de nervios: the role of fear of negative affect and fear of arousal symptoms.

PubMed

Hinton, Devon E; Lewis-Fernández, Roberto; Pollack, Mark H

2009-01-01

This article examines a model of the generation of ataque de nervios, according to which both fear of negative affectivity and fear of arousal symptoms are associated with the emergence of ataques. We examine the relationship of fear of negative affectivity and fear of arousal to the severity of ataque de nervios during the last month and the last 6 months among Caribbean Latinos residing in the United States. The measures include a Fear of Anger Scale and the Anxiety Sensitivity Index (ASI), the ASI augmented with two items that assess fear of arousal symptoms common in ataques: chest tightness and a sense of inner heat. In keeping with the model of ataque generation, one-way analysis of variances (ANOVAs) and discriminant function analyses illustrated that items assessing "fear of negative affect" and "fear of somatic and psychological symptoms of arousal" both differentiated well among the levels of ataque severity. In addition, key ataque symptoms-mental incapacitation fears, shakiness, chest tightness, palpitations, and a sense of inner heat-were the best discriminators among levels of ataque severity. In patients with severe ataques, the scores of "fear of negative affect" and "fear of ataque-de-nervios-type somatic and psychological symptoms" were extremely elevated. This further suggests that both these types of fears are associated with this idiom of distress and that the specific content of the fears is linked to the symptom picture of the idiom. This suggests specific therapeutic targets for the treatment of ataque, namely, the reduction of anxiety sensitivity (and more generally negative-emotion and arousal sensitivity) using cognitive behavioral therapy (CBT), relaxation, and mindfulness techniques.

An Additional Prior Retrieval Alters the Effects of a Retrieval-Extinction Procedure on Recent and Remote Fear Memory

PubMed Central

An, Xianli; Yang, Ping; Chen, Siguang; Zhang, Fenfen; Yu, Duonan

2018-01-01

Several studies have shown that the isolated retrieval of a consolidated fear memory can induce a labile phase, during which extinction training can prevent the reinstatement, a form of relapse in which fear response to a fear-provoking context returns when a mild shock is presented. However, fear memory retrieval may also have another opposing result: the enhancement of fear memory. This implies that the fear memory trace can be modified by a brief retrieval. Unclear is whether the fear-impairing effect of retrieval-extinction (RE) is altered by a prior brief retrieval. The present study investigated the responses of recent and remote fear memories to the RE procedure after the presentation of an additional prior retrieval (priRet). We found that a single RE procedure effectively blocked the reinstatement of 2-day recent contextual fear memory. The memory-impairing effect of the RE procedure on recent fear was not observed when priRet was presented 6 or 24 h before the RE procedure. In contrast to the 2-day recent memory, the RE procedure failed to block the reinstatement of 36-day remote fear memory but successfully disrupted the return of remote fear memory after priRet. This memory-disruptive effect on remote memory did not occur when priRet was performed in a novel context. Nimodipine administration revealed that the blockade of priRet-induced processes recovered the effects of the RE procedure on both recent and remote fear memories. Our findings suggest that the susceptibility of recent and remote fear memories to RE procedures can be altered by an additional retrieval. PMID:29358910

Work-related fear and the threats of fear among emergency department nursing staff and physicians in Finland.

PubMed

Mikkola, Riitta; Huhtala, Heini; Paavilainen, Eija

2017-10-01

To describe fear, the threats causing fear and the occurrence of fear among emergency department nursing staff and physicians. The emergency department is a challenging workplace where the staff is often confronted by factors that cause fear. A cross-sectional study. A survey was conducted in 16 hospitals (n = 544). Nurses, practical nurses, orderlies and physicians from those hospitals participated in the survey. The survey questionnaire was based on the analysis of interviews of 30 nurses from one university hospital and one central hospital. The results of the interviews were analysed using the inductive content analysis method. The analysis of the survey was performed using statistical methods, such as frequencies, cross-tabulation and principal component analysis. The results showed that nearly all of the emergency department personnel had experienced work-related fear. Generally, the fear had been momentary. According to the survey results, fear was most often caused by medication errors, the resuscitation of a child, a catastrophic accident, urgent or violent situations or patients armed with weapons. Threats that caused fear included insecurity, danger in the work environment, threat of loss of one's health and threat of the consequences of one's mistakes and actions. The staff of emergency departments often encountered factors or situations that caused fear. The main threats causing fear that were raised by the respondents were insecurity and danger in the work environment. The data obtained from this study can be utilised in identifying and describing work-related fear and threats of fear among emergency department nursing staff and physicians. Based on the information herein, it will be possible to develop methods to prevent situations that cause fear in emergency departments. © 2016 John Wiley & Sons Ltd.

Oxytocin receptor neurotransmission in the dorsolateral bed nucleus of the stria terminalis facilitates the acquisition of cued fear in the fear-potentiated startle paradigm in rats.

PubMed

Moaddab, Mahsa; Dabrowska, Joanna

2017-07-15

Oxytocin (OT) is a hypothalamic neuropeptide that modulates fear and anxiety-like behaviors. Dorsolateral bed nucleus of the stria terminalis (BNST dl ) plays a critical role in the regulation of fear and anxiety, and expresses high levels of OT receptor (OTR). However, the role of OTR neurotransmission within the BNST dl in mediating these behaviors is unknown. Here, we used adult male Sprague-Dawley rats to investigate the role of OTR neurotransmission in the BNST dl in the modulation of the acoustic startle response, as well as in the acquisition and consolidation of conditioned fear using fear potentiated startle (FPS) paradigm. Bilateral intra-BNST dl administration of OT (100 ng) did not affect the acquisition of conditioned fear response. However, intra-BNST dl administration of specific OTR antagonist (OTA), (d(CH 2 ) 5 1 , Tyr(Me) 2 , Thr 4 , Orn 8 , des-Gly-NH 2 9 )-vasotocin, (200 ng), prior to the fear conditioning session, impaired the acquisition of cued fear, without affecting a non-cued fear component of FPS. Neither OTA, nor OT affected baseline startle or shock reactivity during fear conditioning. Therefore, the observed impairment of cued fear after OTA infusion resulted from the specific effect on the formation of cued fear. In contrast to the acquisition, neither OTA nor OT affected the consolidation of FPS, when administered after the completion of fear conditioning session. Taken together, these results reveal the important role of OTR neurotransmission in the BNST dl in the formation of conditioned fear to a discrete cue. This study also highlights the role of the BNST dl in learning to discriminate between threatening and safe stimuli. Copyright © 2017 Elsevier Ltd. All rights reserved.

Dissociating response systems: erasing fear from memory.

PubMed

Soeter, Marieke; Kindt, Merel

2010-07-01

In addition to the extensive evidence in animals, we previously showed that disrupting reconsolidation by noradrenergic blockade produced amnesia for the original fear response in humans. Interestingly, the declarative memory for the fear association remained intact. These results asked for a solid replication. Moreover, given the constructive nature of memories, the intact recollection of the fear association could eventually 'rebuild' the fear memory, resulting in the spontaneous recovery of the fear response. Yet, perseverance of the amnesic effects would have substantial clinical implications, as even the most effective treatments for psychiatric disorders display high percentages of relapse. Using a differential fear conditioning procedure in humans, we replicated our previous findings by showing that administering propranolol (40mg) prior to memory reactivation eliminated the startle fear response 24h later. But most importantly, this effect persisted at one month follow-up. Notably, the propranolol manipulation not only left the declarative memory for the acquired contingency untouched, but also skin conductance discrimination. In addition, a close association between declarative knowledge and skin conductance responses was found. These findings are in line with the supposed double dissociation of fear conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. They support the view that skin conductance conditioning primarily reflects contingency learning, whereas the startle response is a rather specific measure of fear. Furthermore, the results indicate the absence of a causal link between the actual knowledge of a fear association and its fear response, even though they often operate in parallel. Interventions targeting the amygdalar fear memory may be essential in specifically and persistently dampening the emotional impact of fear. From a clinical and ethical perspective, disrupting reconsolidation points to promising interventions persistently erasing fear responses from trauma memory without affecting the actual recollection.

An Additional Prior Retrieval Alters the Effects of a Retrieval-Extinction Procedure on Recent and Remote Fear Memory.

PubMed

An, Xianli; Yang, Ping; Chen, Siguang; Zhang, Fenfen; Yu, Duonan

2017-01-01

Several studies have shown that the isolated retrieval of a consolidated fear memory can induce a labile phase, during which extinction training can prevent the reinstatement, a form of relapse in which fear response to a fear-provoking context returns when a mild shock is presented. However, fear memory retrieval may also have another opposing result: the enhancement of fear memory. This implies that the fear memory trace can be modified by a brief retrieval. Unclear is whether the fear-impairing effect of retrieval-extinction (RE) is altered by a prior brief retrieval. The present study investigated the responses of recent and remote fear memories to the RE procedure after the presentation of an additional prior retrieval (priRet). We found that a single RE procedure effectively blocked the reinstatement of 2-day recent contextual fear memory. The memory-impairing effect of the RE procedure on recent fear was not observed when priRet was presented 6 or 24 h before the RE procedure. In contrast to the 2-day recent memory, the RE procedure failed to block the reinstatement of 36-day remote fear memory but successfully disrupted the return of remote fear memory after priRet. This memory-disruptive effect on remote memory did not occur when priRet was performed in a novel context. Nimodipine administration revealed that the blockade of priRet-induced processes recovered the effects of the RE procedure on both recent and remote fear memories. Our findings suggest that the susceptibility of recent and remote fear memories to RE procedures can be altered by an additional retrieval.

"It was pretty scary": the theme of fear in young adult women's descriptions of a history of adolescent dating abuse.

PubMed

Burton, Candace W; Halpern-Felsher, Bonnie; Rehm, Roberta S; Rankin, Sally; Humphreys, Janice C

2013-11-01

The mental health impact of abusive adolescent dating relationships has not been well described, but fear related to abuse has been reported. We elaborate the theme of fear in women's descriptions of a history of adolescent dating abuse. A sample of community-based women, ages 19-34, who experienced an abusive dating relationship during adolescence (ages 11-20) was used. Data were analyzed via thematic analysis. Fear was a consistent and resonant theme. Three types of fear were identified: fear for self, fear for other relationships, and fearful expectation. These results offer important insights into the impact of abusive adolescent relationships on women's mental health.

Fear of Crime in the Sanctuary: Comparing American and Ghanaian University Students' Fearfulness.

PubMed

Boateng, Francis D

2018-02-01

While much is known about fear of crime in the West, little is known about how fearfulness of crime develops in non-Western societies, especially among university students. Representing the first attempt to empirically compare levels of fear of crime between Ghanaian and U.S. college students, this article examined students' levels of fear of crime on campus, and tested the applicability of two evolving models of fear of crime-the vulnerability and reassurance models-using comparative data. The general finding is that Ghanaian and U.S. college students differ in terms of their rates of fearfulness on campus. This significant difference adds to the already existing differences between the two countries.

Individual differences in learning predict the return of fear.

PubMed

Gershman, Samuel J; Hartley, Catherine A

2015-09-01

Using a laboratory analogue of learned fear (Pavlovian fear conditioning), we show that there is substantial heterogeneity across individuals in spontaneous recovery of fear following extinction training. We propose that this heterogeneity might stem from qualitative individual differences in the nature of extinction learning. Whereas some individuals tend to form a new memory during extinction, leaving their fear memory intact, others update the original threat association with new safety information, effectively unlearning the fear memory. We formalize this account in a computational model of fear learning and show that individuals who, according to the model, are more likely to form new extinction memories tend to show greater spontaneous recovery compared to individuals who appear to only update a single memory. This qualitative variation in fear and extinction learning may have important implications for understanding vulnerability and resilience to fear-related psychiatric disorders.

Infralimbic EphB2 Modulates Fear Extinction in Adolescent Rats

PubMed Central

Cruz, Emmanuel; Soler-Cedeño, Omar; Negrón, Geovanny; Criado-Marrero, Marangelie; Chompré, Gladys

2015-01-01

Adolescent rats are prone to impaired fear extinction, suggesting that mechanistic differences in extinction could exist in adolescent and adult rats. Since the infralimbic cortex (IL) is critical for fear extinction, we used PCR array technology to identify gene expression changes in IL induced by fear extinction in adolescent rats. Interestingly, the ephrin type B receptor 2 (EphB2), a tyrosine kinase receptor associated with synaptic development, was downregulated in IL after fear extinction. Consistent with the PCR array results, EphB2 levels of mRNA and protein were reduced in IL after fear extinction compared with fear conditioning, suggesting that EphB2 signaling in IL regulates fear extinction memory in adolescents. Finally, reducing EphB2 synthesis in IL with shRNA accelerated fear extinction learning in adolescent rats, but not in adult rats. These findings identify EphB2 in IL as a key regulator of fear extinction during adolescence, perhaps due to the increase in synaptic remodeling occurring during this developmental phase. PMID:26354908

Social anxiety and eating disorder comorbidity: The role of negative social evaluation fears

PubMed Central

Levinson, Cheri A.; Rodebaugh, Thomas L.

2011-01-01

Social anxiety and eating disorders are highly comorbid. However, it is unknown how specific domains of social anxiety relate to disordered eating. We provide data on these relationships and investigate social appearance anxiety and fear of negative evaluation as potential vulnerabilities linking social anxiety with eating disorders. Specifically, we examined five domains of social anxiety: Social interaction anxiety, fear of scrutiny, fear of positive evaluation, fear of negative evaluation, and social appearance anxiety. Results indicated that social appearance anxiety predicted body dissatisfaction, bulimia symptoms, shape concern, weight concern, and eating concern over and above fear of scrutiny, social interaction anxiety, and fear of positive evaluation. Fear of negative evaluation uniquely predicted drive for thinness and restraint. Structural equation modeling supported a model in which social appearance anxiety and fear of negative evaluation are vulnerabilities for both social anxiety and eating disorder symptoms. Interventions that target these negative social evaluation fears may help prevent development of eating disorders. PMID:22177392

Fear conditioned responses and PTSD symptoms in children: Sex differences in fear-related symptoms.

PubMed

Gamwell, Kaitlyn; Nylocks, Maria; Cross, Dorthie; Bradley, Bekh; Norrholm, Seth D; Jovanovic, Tanja

2015-11-01

Fear conditioning studies in adults have found that posttraumatic stress disorder (PTSD) is associated with heightened fear responses and impaired discrimination. The objective of the current study was to examine the association between PTSD symptoms and fear conditioned responses in children from a highly traumatized urban population. Children between 8 and 13 years old participated in a fear conditioning study in addition to providing information about their trauma history and PTSD symptoms. Results showed that females showed less discrimination between danger and safety signals during conditioning compared to age-matched males. In boys, intrusive symptoms were predictive of fear responses, even after controlling for trauma exposure. However, in girls, conditioned fear to the danger cue was predictive of self-blame and fear of repeated trauma. This study suggests there are early sex differences in the patterns of fear conditioning and that these sex differences may translate to differential risk for trauma-related psychopathology. © 2015 Wiley Periodicals, Inc.

Vicarious Learning and Reduction of Fear in Children via Adult and Child Models.

PubMed

Dunne, Güler; Askew, Chris

2017-06-01

Children can learn to fear stimuli vicariously, by observing adults' or peers' responses to them. Given that much of school-age children's time is typically spent with their peers, it is important to establish whether fear learning from peers is as effective or robust as learning from adults, and also whether peers can be successful positive models for reducing fear. During a vicarious fear learning procedure, children (6 to 10 years; N = 60) were shown images of novel animals together with images of adult or peer faces expressing fear. Later they saw their fear-paired animal again together with positive emotional adult or peer faces. Children's fear beliefs and avoidance for the animals increased following vicarious fear learning and decreased following positive vicarious counterconditioning. There was little evidence of differences in learning from adults and peers, demonstrating that for this age group peer models are effective models for both fear acquisition and reduction. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Cellular and oscillatory substrates of fear extinction learning.

PubMed

Davis, Patrick; Zaki, Yosif; Maguire, Jamie; Reijmers, Leon G

2017-11-01

The mammalian brain contains dedicated circuits for both the learned expression and suppression of fear. These circuits require precise coordination to facilitate the appropriate expression of fear behavior, but the mechanisms underlying this coordination remain unclear. Using a combination of chemogenetics, activity-based neuronal-ensemble labeling and in vivo electrophysiology, we found that fear extinction learning confers on parvalbumin-expressing (PV) interneurons in the basolateral amygdala (BLA) a dedicated role in the selective suppression of a previously encoded fear memory and BLA fear-encoding neurons. In addition, following extinction learning, PV interneurons enable a competing interaction between a 6-12 Hz oscillation and a fear-associated 3-6 Hz oscillation within the BLA. Loss of this competition increases a 3-6 Hz oscillatory signature, with BLA→medial prefrontal cortex directionality signaling the recurrence of fear expression. The discovery of cellular and oscillatory substrates of fear extinction learning that critically depend on BLA PV interneurons could inform therapies aimed at preventing the pathological recurrence of fear following extinction learning.

Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.

PubMed

Kim, Woong Bin; Cho, Jun-Hyeong

2017-08-30

In auditory fear conditioning, experimental subjects learn to associate an auditory conditioned stimulus (CS) with an aversive unconditioned stimulus. With sufficient training, animals fear conditioned to an auditory CS show fear response to the CS, but not to irrelevant auditory stimuli. Although long-term potentiation (LTP) in the lateral amygdala (LA) plays an essential role in auditory fear conditioning, it is unknown whether LTP is induced selectively in the neural pathways conveying specific CS information to the LA in discriminative fear learning. Here, we show that postsynaptically expressed LTP is induced selectively in the CS-specific auditory pathways to the LA in a mouse model of auditory discriminative fear conditioning. Moreover, optogenetically induced depotentiation of the CS-specific auditory pathways to the LA suppressed conditioned fear responses to the CS. Our results suggest that input-specific LTP in the LA contributes to fear memory specificity, enabling adaptive fear responses only to the relevant sensory cue. VIDEO ABSTRACT. Copyright © 2017 Elsevier Inc. All rights reserved.

Negative Social Evaluative Fears Produce Social Anxiety, Food Intake, and Body Dissatisfaction: Evidence of Similar Mechanisms through Different Pathways

PubMed Central

Levinson, Cheri A.; Rodebaugh, Thomas L.

2014-01-01

Social anxiety and eating disorders are highly comorbid, suggesting there are shared vulnerabilities that underlie the development of these disorders. Two proposed vulnerabilities are fear of negative evaluation and social appearance anxiety (i.e., fear of negative evaluation regarding one's appearance). In the current experimental study (N=160 women) we measured these fears: (a) through a manipulation comparing fear conditions, (b) with trait fears, and (c) state fears. Results indicated that participants in the fear of negative evaluation condition increased food consumption, whereas participants in the social appearance anxiety condition and high in trait social appearance anxiety experienced the highest amounts of body dissatisfaction. Participants in the fear of evaluation and social appearance anxiety conditions experienced elevated social anxiety. These results support the idea that negative evaluation fears are shared vulnerabilities for eating and social anxiety disorders, but that the way these variables exert their effects may lead to disorder specific behaviors. PMID:26504674

Social anxiety and eating disorder comorbidity: the role of negative social evaluation fears.

PubMed

Levinson, Cheri A; Rodebaugh, Thomas L

2012-01-01

Social anxiety and eating disorders are highly comorbid. However, it is unknown how specific domains of social anxiety relate to disordered eating. We provide data on these relationships and investigate social appearance anxiety and fear of negative evaluation as potential vulnerabilities linking social anxiety with disordered eating. Specifically, we examined five domains of social anxiety: Social interaction anxiety, fear of scrutiny, fear of positive evaluation, fear of negative evaluation, and social appearance anxiety. Results indicated that social appearance anxiety predicted body dissatisfaction, bulimic symptoms, shape concern, weight concern, and eating concern over and above fear of scrutiny, social interaction anxiety, and fear of positive evaluation. Fear of negative evaluation uniquely predicted drive for thinness and restraint. Structural equation modeling supported a model in which social appearance anxiety and fear of negative evaluation are vulnerabilities for both social anxiety and eating disorder symptoms. Interventions that target these negative social evaluation fears may help prevent development of eating disorders. Copyright © 2011 Elsevier Ltd. All rights reserved.

Cellular and Oscillatory Substrates of Fear Extinction Learning

PubMed Central

Davis, Patrick; Zaki, Yosif; Maguire, Jamie; Reijmers, Leon G.

2018-01-01

The mammalian brain contains dedicated circuits for both the learned expression and suppression of fear. These circuits require precise coordination to facilitate the appropriate expression of fear behavior, but the mechanisms underlying this coordination remain unclear. Using a novel combination of chemogenetics, activity-based neuronal-ensemble labeling, and in vivo electrophysiology, we found that fear extinction learning confers parvalbumin-expressing (PV) interneurons in the basolateral amygdala (BLA) with a dedicated role in the selective suppression of a previously encoded fear memory and BLA fear-encoding neurons. In addition, following extinction learning, PV interneurons enable a competing interaction between a 6–12 Hz oscillation and a fear-associated 3–6 Hz oscillation within the BLA. Loss of this competition increases a 3–6 Hz oscillatory signature, with BLA→mPFC directionality signaling the recurrence of fear expression. The discovery of cellular and oscillatory substrates of fear extinction learning that critically depend on BLA PV-interneurons could inform therapies aimed at preventing the pathological recurrence of fear following extinction learning. PMID:28967909

Geologic framework of the northern North Carolina, USA inner continental shelf and its influence on coastal evolution

USGS Publications Warehouse

Thieler, E. Robert; Foster, David S.; Himmelstoss, Emily A.; Mallinson, David J.

2013-01-01

The inner continental shelf off the northern Outer Banks of North Carolina was mapped using sidescan sonar, interferometric swath bathymetry, and high-resolution chirp and boomer subbottom profiling systems. We use this information to describe the shallow stratigraphy, reinterpret formation mechanisms of some shoal features, evaluate local relative sea-levels during the Late Pleistocene, and provide new constraints, via recent bedform evolution, on regional sediment transport patterns. The study area is approximately 290 km long by 11 km wide, extending from False Cape, Virginia to Cape Lookout, North Carolina, in water depths ranging from 6 to 34 m. Late Pleistocene sedimentary units comprise the shallow geologic framework of this region and determine both the morphology of the inner shelf and the distribution of sediment sources and sinks. We identify Pleistocene sedimentary units beneath Diamond Shoals that may have provided a geologic template for the location of modern Cape Hatteras and earlier paleo-capes during the Late Pleistocene. These units indicate shallow marine deposition 15–25 m below present sea-level. The uppermost Pleistocene unit may have been deposited as recently as Marine Isotope Stage 3, although some apparent ages for this timing may be suspect. Paleofluvial valleys incised during the Last Glacial Maximum traverse the inner shelf throughout the study area and dissect the Late Pleistocene units. Sediments deposited in the valleys record the Holocene transgression and provide insight into the evolutionary history of the barrier-estuary system in this region. The relationship between these valleys and adjacent shoal complexes suggests that the paleo-Roanoke River did not form the Albemarle Shelf Valley complex as previously proposed; a major fluvial system is absent and thus makes the formation of this feature enigmatic. Major shoal features in the study area show mobility at decadal to centennial timescales, including nearly a kilometer of shoal migration over the past 134 yr. Sorted bedforms occupy ~ 1000 km2 of seafloor in Raleigh Bay, and indicate regional sediment transport patterns between Capes Hatteras and Lookout that help explain long-term sediment accumulation and morphologic development. Portions of the inner continental shelf with relatively high sediment abundance are characterized by shoals and shoreface-attached ridges, and where sediment is less abundant, the seafloor is dominated by sorted bedforms. These relationships are also observed in other passive margin settings, suggesting a continuum of shelf morphology that may have broad application for interpreting inner shelf sedimentation patterns.

Fears of Children in the United States: An Examination of the American Fear Survey Schedule with 20 New Contemporary Fear Items

ERIC Educational Resources Information Center

Burnham, Joy J.

2005-01-01

Twenty contemporary fears (e.g., terrorist attacks, drive-by shootings, having to fight in a war) were added to E. Gullone and N. J. King's (1992) Australian Fear Survey Schedule for Children-II for use in the United States. The revised survey, the American Fear Survey Schedule for Children (J. J. Burnham, 1995), was investigated. The component…

Comparing Electric Shock and a Fearful Screaming Face as Unconditioned Stimuli for Fear Learning

PubMed Central

Glenn, Catherine R.; Lieberman, Lynne; Hajcak, Greg

2012-01-01

The potency of an unconditioned stimulus (UCS) can impact the degree of fear learning. One of the most common and effective UCSs is an electric shock, which is inappropriate for certain populations (e.g., children). To address this need, a novel fear learning paradigm was recently developed that uses a fearful female face and scream as the UCS. The present study directly compared the efficacy of the screaming female UCS and a traditional shock UCS in two fear learning paradigms. Thirty-six young adults completed two fear learning tasks and a measure of trait anxiety; fear learning was indexed with fear-potentiated startle (FPS) and self-reported fear ratings. Results indicated comparable FPS across the two tasks. However, larger overall startle responses were exhibited in the shock task, and participants rated the shock UCS and overall task as more aversive than the screaming female. In addition, trait anxiety was only related to FPS in the fear learning task that employed a shock as the UCS. Taken together, results indicate that, although both UCS paradigms can be used for fear conditioning (i.e., to produce differences between CS+ and CS−), the shock UCS paradigm is more aversive and potentially more sensitive to individual differences in anxiety. PMID:23007035

Dental Fear and Avoidance in Treatment Seekers at a Large, Urban Dental Clinic.

PubMed

Heyman, Richard E; Slep, Amy M Smith; White-Ajmani, Mandi; Bulling, Lisanne; Zickgraf, Hana F; Franklin, Martin E; Wolff, Mark S

2016-01-01

The prevalence and correlates of dental fear have been studied in representative population studies, but not in patients presenting for dental treatment. We hypothesized that dental fear among patients presenting at a large, urban college of dentistry would be similar to that of the population (e.g. 11% high dental fear, 17% to 35% moderate or higher fear) and that fear would be associated with avoidance of routine dental care, increased use of urgent dental care and poor oral health. Participants were 1070 consecutive patients at a large, urban dental care center. All patients completed a clinical interview, including demographics, medical history, dental history and presenting concerns, and behavioral health history. Patients were also asked to rate their dental anxiety/fear on a 1 (none) to 10 (high) scale. Over 20% of patients reported elevated anxiety/fear, of which 12.30% reported moderate and 8.75% high fear. Severity of dental anxiety/fear was strongly related to the likelihood of avoiding dental services in the past and related to myriad presenting problems. As hypothesized, the prevalence of moderate or higher fear in dental patients was considerable and closely matched that found in general population surveys. Thus, the 'dental home' is an ideal location to treat clinically significant dental anxiety/fear.

Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice.

PubMed

Alvarez-Ricartes, Nathalie; Oliveros-Matus, Patricia; Mendoza, Cristhian; Perez-Urrutia, Nelson; Echeverria, Florencia; Iarkov, Alexandre; Barreto, George E; Echeverria, Valentina

2018-02-27

Failure in fear extinction is one of the more troublesome characteristics of posttraumatic stress disorder (PTSD). Cotinine facilitates fear memory extinction and reduces depressive-like behavior when administered 24 h after fear conditioning in mice. In this study, it was investigated the behavioral and molecular effects of cotinine, and other antidepressant preparations infused intranasally. Intranasal (IN) cotinine, IN krill oil, IN cotinine plus krill oil, and oral sertraline were evaluated on depressive-like behavior and fear retention and extinction after fear conditioning in C57BL/6 mice. Since calcineurin A has been involved in facilitating fear extinction in rodents, we also investigated changes of calcineurin in the hippocampus, a region key on contextual fear extinction. Short-term treatment with cotinine formulations was superior to krill oil and oral sertraline in reducing depressive-like behavior and fear consolidation and enhancing contextual fear memory extinction in mice. IN krill oil slowed the extinction of fear. IN cotinine preparations increased the levels of calcineurin A in the hippocampus of conditioned mice. In the light of the results, the future investigation of the use of IN cotinine preparations for the extinction of contextual fear memory and treatment of treatment-resistant depression (TRD) in PTSD is discussed.

Parents' perception of children's fear: from FSSC-IT to FSSC-PP

PubMed Central

Salcuni, Silvia; Dazzi, Carla; Mannarini, Stefania; Di Riso, Daniela; Delvecchio, Elisa

2015-01-01

Studies involving parents' reports about children's fears and multiple informant comparisons are less extended than investigations on children's self-reporting fear schedules. Starting with the Italian version of FSSC-R, the FSSC-IT, the main aims of this study were to adapt a schedule for parents' perception of their children's fear: the FSSC-Parent Perception. Its psychometric properties were examined in a large sample of parents (N = 2970) of children aged 8–10 years. Exploratory and confirmatory factorial structures were examined and compared with the Italian children's ones. Mother vs. father, children's gender and school age group effects were analyzed. The confirmatory factor analysis confirmed a four correlated factors solution model (Fear of Danger and Death; Fear of Injury and Animals; Fear of Failure and Criticism; Fear of the unknown and Phobic aspects). Some effects related to child gender, age group, mother vs. father, were found. The FSSC-PP properties supported its use by parents to assess their children's fears. A qualitative analysis of the top 10 fears most endorsed by parents will be presented and compared with children's fears. Clinical implications about the quality of parent-child relationships where discussed, comparing mothers and fathers, and parents' perception about daughters' and sons' most endorsed fears. PMID:26322004

Gradients of fear: How perception influences fear generalization.

PubMed

Struyf, Dieter; Zaman, Jonas; Hermans, Dirk; Vervliet, Bram

2017-06-01

The current experiment investigated whether overgeneralization of fear could be due to an inability to perceptually discriminate the initial fear-evoking stimulus from similar stimuli, as fear learning-induced perceptual impairments have been reported but their influence on generalization gradients remain to be elucidated. Three hundred and sixty-eight healthy volunteers participated in a differential fear conditioning paradigm with circles of different sizes as conditioned stimuli (CS), of which one was paired to an aversive IAPS picture. During generalization, each subject was presented with one of 10 different sized circles including the CSs, and were asked to categorize the stimulus as either a CS or as novel after fear responses were recorded. Linear mixed models were used to investigate differences in fear generalization gradients depending on the participant's perception of the test stimulus. We found that the incorrect perception of a novel stimulus as the initial fear-evoking stimulus strongly boosted fear responses. The current findings demonstrate that a significant number of novel stimuli used to assess generalization are incorrectly identified as the initial fear-evoking stimulus, providing a perceptual account for the observed overgeneralization in panic and anxiety disorders. Accordingly, enhancing perceptual processing may be a promising treatment for targeting excessive fear generalization. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear.

PubMed

D'Amico, Davide; Gener, Thomas; de Lagrán, Maria Martínez; Sanchez-Vives, Maria V; Santos, Mónica; Dierssen, Mara

2017-01-01

The inability to properly extinguish fear memories constitutes the foundation of several anxiety disorders, including panic disorder. Recent findings show that boosting prefrontal cortex synaptic plasticity potentiates fear extinction, suggesting that therapies that augment synaptic plasticity could prove useful in rescue of fear extinction impairments in this group of disorders. Previously, we reported that mice with selective deregulation of neurotrophic tyrosine kinase receptor, type 3 expression (TgNTRK3) exhibit increased fear memories accompanied by impaired extinction, congruent with an altered activation pattern of the amygdala-hippocampus-medial prefrontal cortex fear circuit. Here we explore the specific role of neurotrophin 3 and its cognate receptor in the medial prefrontal cortex, and its involvement in fear extinction in a pathological context. In this study we combined molecular, behavioral, in vivo pharmacology and ex vivo electrophysiological recordings in TgNTRK3 animals during contextual fear extinction processes. We show that neurotrophin 3 protein levels are increased upon contextual fear extinction in wild-type animals but not in TgNTRK3 mice, which present deficits in infralimbic long-term potentiation. Importantly, infusion of neurotrophin 3 to the medial prefrontal cortex of TgNTRK3 mice rescues contextual fear extinction and ex vivo local application improves medial prefrontal cortex synaptic plasticity. This effect is blocked by inhibition of extracellular signal-regulated kinase phosphorylation through peripheral administration of SL327, suggesting that rescue occurs via this pathway. Our results suggest that stimulating neurotrophin 3-dependent medial prefrontal cortex plasticity could restore contextual fear extinction deficit in pathological fear and could constitute an effective treatment for fear-related disorders.

The Role Of Basal Forebrain Cholinergic Neurons In Fear and Extinction Memory

PubMed Central

Knox, Dayan

2016-01-01

Cholinergic input to the neocortex, dorsal hippocampus (dHipp), and basolateral amygdala (BLA) is critical for neural function and synaptic plasticity in these brain regions. Synaptic plasticity in the neocortex, dHipp, ventral Hipp (vHipp), and BLA has also been implicated in fear and extinction memory. This finding raises the possibility that basal forebrain (BF) cholinergic neurons, the predominant source of acetylcholine in these brain regions, have an important role in mediating fear and extinction memory. While empirical studies support this hypothesis, there are interesting inconsistencies among these studies that raise questions about how best to define the role of BF cholinergic neurons in fear and extinction memory. Nucleus basalis magnocellularis (NBM) cholinergic neurons that project to the BLA are critical for fear memory and contextual fear extinction memory. NBM cholinergic neurons that project to the neocortex are critical for cued and contextual fear conditioned suppression, but are not critical for fear memory in other behavioral paradigms and in the inhibitory avoidance paradigm may even inhibit contextual fear memory formation. Medial septum and diagonal band of Broca cholinergic neurons are critical for contextual fear memory and acquisition of cued fear extinction. Thus, even though the results of previous studies suggest BF cholinergic neurons modulate fear and extinction memory, inconsistent findings among these studies necessitates more research to better define the neural circuits and molecular processes through which BF cholinergic neurons modulate fear and extinction memory. Furthermore, studies determining if BF cholinergic neurons can be manipulated in such a manner so as to treat excessive fear in anxiety disorders are needed. PMID:27264248

Ictal fear: Associations with age, gender, and other experiential phenomena.

PubMed

Chong, Derek J; Dugan, Patricia

2016-09-01

The aim of this study was to determine the relationship of fear to other auras and to gender and age using a large database. The Epilepsy Phenome/Genome Project (EPGP) is a multicenter, multicontinental cross-sectional study in which ictal symptomatology and other data were ascertained in a standardized series of questionnaires then corroborated by epilepsy specialists. Auras were classified into subgroups of symptoms, with ictal fear, panic, or anxiety as a single category. Of 536 participants with focal epilepsy, 72 were coded as having ictal fear/panic/anxiety. Reviewing raw patient responses, 12 participants were deemed not to have fear, and 24 had inadequate data, leaving 36 (7%) of 512 with definite ictal fear. In univariate analyses, fear was significantly associated with auras historically considered temporal lobe in origin, including cephalic, olfactory, and visceral complaints; déjà vu; and derealization. On both univariate and multivariate stepwise analyses, fear was associated with jamais vu and auras with cardiac symptoms, dyspnea, and chest tightening. Expressive aphasia was associated with fear on univariate analysis only, but the general category of aphasias was associated with fear only in the multivariate model. There was no age or gender relationship with fear when compared to the overall population with focal epilepsy that was studied under the EPGP. Patients with ictal fear were more likely to have a right hemisphere seizure focus. Ictal fear was strongly associated with other auras considered to originate from the limbic system. No relationship of fear with age or gender was observed. Copyright © 2016 Elsevier Inc. All rights reserved.

Dendritic structural plasticity in the basolateral amygdala after fear conditioning and its extinction in mice

PubMed Central

Heinrichs, Stephen C.; Leite-Morris, Kimberly A.; Guy, Marsha D.; Goldberg, Lisa R.; Young, Angela J.; Kaplan, Gary B.

2015-01-01

Previous research suggests that morphology and arborization of dendritic spines change as a result of fear conditioning in cortical and subcortical brain regions. This study uniquely aims to delineate these structural changes in the basolateral amygdala (BLA) after both fear conditioning and fear extinction. C57BL/6 mice acquired robust conditioned fear responses (70–80% cued freezing behavior) after six pairings with a tone cue associated with footshock in comparison to unshocked controls. During fear acquisition, freezing behavior was significantly affected by both shock exposure and trial number. For fear extinction, mice were exposed to the conditioned stimulus tone in the absence of shock administration and behavioral responses significantly varied by shock treatment. In the retention tests over 3 weeks, the percentage time spent freezing varied with the factor of extinction training. In all treatment groups, alterations in dendritic plasticity were analyzed using Golgi–Cox staining of dendrites in the BLA. Spine density differed between the fear conditioned group and both the fear extinction and control groups on third order dendrites. Spine density was significantly increased in the fear conditioned group compared to the fear extinction group and controls. Similarly in Sholl analyses, fear conditioning significantly increased BLA spine numbers and dendritic intersections while subsequent extinction training reversed these effects. In summary, fear extinction produced enduring behavioral plasticity that is associated with a reversal of alterations in BLA dendritic plasticity produced by fear conditioning. These neuroplasticity findings can inform our understanding of structural mechanisms underlying stress-related pathology can inform treatment research into these disorders. PMID:23570859

The Medial Amygdala-Medullary PrRP-Synthesizing Neuron Pathway Mediates Neuroendocrine Responses to Contextual Conditioned Fear in Male Rodents

PubMed Central

Yoshida, Masahide; Takayanagi, Yuki

2014-01-01

Fear responses play evolutionarily beneficial roles, although excessive fear memory can induce inappropriate fear expression observed in posttraumatic stress disorder, panic disorder, and phobia. To understand the neural machineries that underlie these disorders, it is important to clarify the neural pathways of fear responses. Contextual conditioned fear induces freezing behavior and neuroendocrine responses. Considerable evidence indicates that the central amygdala plays an essential role in expression of freezing behavior after contextual conditioned fear. On the other hand, mechanisms of neuroendocrine responses remain to be clarified. The medial amygdala (MeA), which is activated after contextual conditioned fear, was lesioned bilaterally by infusion of N-methyl-d-aspartate after training of fear conditioning. Plasma oxytocin, ACTH, and prolactin concentrations were significantly increased after contextual conditioned fear in sham-lesioned rats. In MeA-lesioned rats, these neuroendocrine responses but not freezing behavior were significantly impaired compared with those in sham-lesioned rats. In contrast, the magnitudes of neuroendocrine responses after exposure to novel environmental stimuli were not significantly different in MeA-lesioned rats and sham-lesioned rats. Contextual conditioned fear activated prolactin-releasing peptide (PrRP)-synthesizing neurons in the medulla oblongata. In MeA-lesioned rats, the percentage of PrRP-synthesizing neurons activated after contextual conditioned fear was significantly decreased. Furthermore, neuroendocrine responses after contextual conditioned fear disappeared in PrRP-deficient mice. Our findings suggest that the MeA-medullary PrRP-synthesizing neuron pathway plays an important role in neuroendocrine responses to contextual conditioned fear. PMID:24877622