Science.gov

Sample records for fast response modeling

  1. Urban dispersion : challenges for fast response modeling

    SciTech Connect

    Brown, M. J.

    2004-01-01

    There is renewed interest in urban dispersion modeling due to the need for tools that can be used for responding to, planning for, and assessing the consequences of an airborne release of toxic materials. Although not an everyday phenomenon, releases of hazardous gases and aerosols have occurred in populated urban environments and are potentially threatening to human life. These releases may stem from on-site accidents as in the case of industrial chemical releases, may result during transport of hazardous chemicals as in tanker truck or railroad spills, or may be premeditated as in a chemical, biological, or radiological (CBR) agent terrorist attack. Transport and dispersion in urban environments is extremely complicated. Buildings alter the flow fields and deflect the wind, causing updrafts and downdrafts, channeling between buildings, areas of calm winds adjacent to strong winds, and horizontally and vertically rotating-eddies between buildings, at street corners, and other places within the urban canopy (see review by Hosker, 1984). Trees, moving vehicles, and exhaust vents among other things further complicate matters. The distance over which chemical, biological, or radiological releases can be harmful varies from tens of meters to many kilometers depending on the amount released, the toxicity of the agent, and the atmospheric conditions. As we will show later, accounting for the impacts of buildings on the transport and dispersion is crucial in estimating the travel direction, the areal extent, and the toxicity levels of the contaminant plume, and ultimately for calculating exposures to the population.

  2. FAST Mast Structural Response to Axial Loading: Modeling and Verification

    NASA Technical Reports Server (NTRS)

    Knight, Norman F., Jr.; Elliott, Kenny B.; Templeton, Justin D.; Song, Kyongchan; Rayburn, Jeffery T.

    2012-01-01

    The International Space Station s solar array wing mast shadowing problem is the focus of this paper. A building-block approach to modeling and analysis is pursued for the primary structural components of the solar array wing mast structure. Starting with an ANSYS (Registered Trademark) finite element model, a verified MSC.Nastran (Trademark) model is established for a single longeron. This finite element model translation requires the conversion of several modeling and analysis features for the two structural analysis tools to produce comparable results for the single-longeron configuration. The model is then reconciled using test data. The resulting MSC.Nastran (Trademark) model is then extended to a single-bay configuration and verified using single-bay test data. Conversion of the MSC. Nastran (Trademark) single-bay model to Abaqus (Trademark) is also performed to simulate the elastic-plastic longeron buckling response of the single bay prior to folding.

  3. A CFD-based wind solver for a fast response transport and dispersion model

    SciTech Connect

    Gowardhan, Akshay A; Brown, Michael J; Pardyjak, Eric R; Senocak, Inanc

    2010-01-01

    In many cities, ambient air quality is deteriorating leading to concerns about the health of city inhabitants. In urban areas with narrow streets surrounded by clusters of tall buildings, called street canyons, air pollution from traffic emissions and other sources is difficult to disperse and may accumulate resulting in high pollutant concentrations. For various situations, including the evacuation of populated areas in the event of an accidental or deliberate release of chemical, biological and radiological agents, it is important that models should be developed that produce urban flow fields quickly. For these reasons it has become important to predict the flow field in urban street canyons. Various computational techniques have been used to calculate these flow fields, but these techniques are often computationally intensive. Most fast response models currently in use are at a disadvantage in these cases as they are unable to correlate highly heterogeneous urban structures with the diagnostic parameterizations on which they are based. In this paper, a fast and reasonably accurate computational fluid dynamics (CFD) technique that solves the Navier-Stokes equations for complex urban areas has been developed called QUIC-CFD (Q-CFD). This technique represents an intermediate balance between fast (on the order of minutes for a several block problem) and reasonably accurate solutions. The paper details the solution procedure and validates this model for various simple and complex urban geometries.

  4. Development and validation of a two-dimensional fast-response flood estimation model

    SciTech Connect

    Judi, David R; Mcpherson, Timothy N; Burian, Steven J

    2009-01-01

    A finite difference formulation of the shallow water equations using an upwind differencing method was developed maintaining computational efficiency and accuracy such that it can be used as a fast-response flood estimation tool. The model was validated using both laboratory controlled experiments and an actual dam breach. Through the laboratory experiments, the model was shown to give good estimations of depth and velocity when compared to the measured data, as well as when compared to a more complex two-dimensional model. Additionally, the model was compared to high water mark data obtained from the failure of the Taum Sauk dam. The simulated inundation extent agreed well with the observed extent, with the most notable differences resulting from the inability to model sediment transport. The results of these validation studies complex two-dimensional model. Additionally, the model was compared to high water mark data obtained from the failure of the Taum Sauk dam. The simulated inundation extent agreed well with the observed extent, with the most notable differences resulting from the inability to model sediment transport. The results of these validation studies show that a relatively numerical scheme used to solve the complete shallow water equations can be used to accurately estimate flood inundation. Future work will focus on further reducing the computation time needed to provide flood inundation estimates for fast-response analyses. This will be accomplished through the efficient use of multi-core, multi-processor computers coupled with an efficient domain-tracking algorithm, as well as an understanding of the impacts of grid resolution on model results.

  5. Implementation of rooftop reciculation parameterization into the QUIC fast response urban wind model

    SciTech Connect

    Bagal, N.; Singh, B.; Pardyjak, E. R.; Brown, M. J.

    2004-01-01

    The QUIC (Quick Urban & Industrial Complex) dispersion modeling system has been developed to provide high-resolution wind and concentration fields in cities. The fast response 3D urban wind model QUIC-URB explicitly solves for the flow field around buildings using a suite of empirical parameterizations and mass conservation. This procedure is based on the work of Rockle (1990). The current Rockle (1990) model does not capture the rooftop recirculation region associated with flow separation from the leading edge of an isolated building. According to Banks et al. (2001), there are two forms of separation depending on the incident wind angle. For an incident wind angle within 20{sup o} of perpendicular to the front face of the building, 'bubble separation' occurs in which cylindrical vortices whose axis are orthogonal to the flow are generated along the rooftop surface (see Fig. 1). For a 'corner wind' flow or incident wind angle of 30{sup o} to 70{sup o} of perpendicular to the front face of the building, 'conical' or 'delta wing' vortices form along the roof surface (Fig. 3). In this work, a model for rooftop recirculation is implemented into the QUIC- URB model for the two incident wind angle regimes described above. The parameterizations for the length and height of the recirculation region are from Wilson (1979) for the case of flow perpendicular or near perpendicular to the building and from Banks et al. (2000) for the case of off-angle flow. In this paper, we describe the rooftop algorithms and show how the model results are improved through comparisons to experimental data (Snyder and Lawson 1994).

  6. Modeling the viscoplastic micromechanical response of two-phase materials using fast Fourier transforms

    SciTech Connect

    Lebensohn, Ricardo A; Lee, Sukbin; Rollett, Anthony D

    2009-01-01

    A viscoplastic approach using the Fast Fourier Transform (FFT) method for obtaining local mechanical response is utilized to study microstructure-property relationships in composite materials. Specifically, three-dimensional, two-phase digital materials containing isotropically coarsened particles surrounded by a matrix phase, generated through a Kinetic Monte Carlo Potts model for Ostwald ripening, are used as instantiations in order to calculate the stress and strain rate fields under uniaxial tension. The effects of the morphology of the matrix phase, the volume fraction and the contiguity of particles, and the polycrystallinity of matrix phase, on the stress and strain rate fields under uniaxial tension are examined. It is found that the first moments of the stress and strain rate fields have a different dependence on the particle volume fraction and the particle contiguity from their second moments. The average stresses and average strain rates of both phases and of the overall composite have rather simple relationships with the particle volume fraction whereas their standard deviations vary strongly, especially when the particle volume fraction is high, and the contiguity of particles has a noticeable effect on the mechanical response. It is also found that the shape of stress distribution in the BCC hard particle phase evolves as the volume fraction of particles in the composite varies, such that it agrees with the stress field in the BCC polycrystal as the volume of particles approaches unity. Finally, it is observed that the stress and strain rate fields in the microstructures with a polycrystalline matrix are less sensitive to changes in volume fraction and contiguity of particles.

  7. Fast response sequential measurements and modelling of nanoparticles inside and outside a car cabin

    NASA Astrophysics Data System (ADS)

    Joodatnia, Pouyan; Kumar, Prashant; Robins, Alan

    2013-06-01

    Commuters are regularly exposed to short-term peak concentration of traffic produced nanoparticles (i.e. particles <300 nm in size). Studies indicate that these exposures pose adverse health effects (i.e. cardiovascular). This study aims to obtain particle number concentrations (PNCs) and distributions (PNDs) inside and outside a car cabin whilst driving on a road in Guildford, a typical UK town. Other objectives are to: (i) investigate the influences of particle transformation processes on particle number and size distributions in the cabin, (ii) correlate PNCs inside the cabin to those measured outside, and (iii) predict PNCs in the cabin based on those outside the cabin using a semi-empirical model. A fast response differential mobility spectrometer (DMS50) was employed in conjunction with an automatic switching system to measure PNCs and PNDs in the 5-560 nm range at multiple locations inside and outside the cabin at 10 Hz sampling rate over 10 s sequential intervals. Two separate sets of measurements were made at: (i) four seats in the car cabin during ˜700 min of driving, and (ii) two points, one the driver seat and the other near the ventilation air intake outside the cabin, during ˜500 min of driving. Results of the four-point measurements indicated that average PNCs at all for locations were nearly identical (i.e. 3.96, 3.85, 3.82 and 4.00 × 104 cm-3). The modest difference (˜0.1%) revealed a well-mixed distribution of nanoparticles in the car cabin. Similar magnitude and shapes of PNDs at all four sampling locations suggested that transformation processes (e.g. nucleation, coagulation, condensation) have minimal effect on particles in the cabin. Two-point measurements indicated that on average, PNCs inside the cabin were about 72% of those measured outside. Time scale analysis indicated that dilution was the fastest and dominant process in the cabin, governing the variations of PNCs in time. A semi-empirical model was proposed to predict PNCs inside

  8. Fast response liquid crystal devices

    NASA Astrophysics Data System (ADS)

    Wu, Yung-Hsun

    LC-based VOA. In Chapter 7, we report a new device called axially-symmetric sheared polymer network liquid crystals (AS-SPNLC) and use it as LC devices. Through analyzing the structure of this axially-symmetric SPNLC, we construct a 3-D model to explain the observed phenomena. An axially-symmetric sheared polymer network liquid crystal has several attractive features: (1) it is polarization independent, (2) it has gradient phase change, and (3) its response time is fast. It can be used for polarization converter and divergent LC lens. In addition, a new method for simultaneously measuring the phase retardation and optic axis of a compensation film is demonstrated using an axially-symmetric sheared polymer network liquid crystal. By overlaying a tested compensation film with a calibrated SPNLC cell between crossed polarizers, the optic axis and phase retardation value of the compensation film can be determined. This simple technique can be used for simultaneously measuring the optic axis and phase retardations of both A- and C-plates. These compensation films have been used extensively in wide-view LCD industry. Therefore, this method will make an important impact to the LCD industry.

  9. Fast-response cloud chamber

    NASA Technical Reports Server (NTRS)

    Fogal, G. L.

    1977-01-01

    Wall structure keeps chambers at constant, uniform temperature, yet allows them to be cooled rapidly if necessary. Wall structure, used in fast-response cloud chamber, has surface heater and coolant shell separated by foam insulation. It is lightweight and requires relatively little power.

  10. EVALUATION OF A FAST-RESPONSE URBAN WIND MODEL - COMPARISON TO SINGLE-BUILDING WIND TUNNEL DATA

    SciTech Connect

    E.R. PARDYJAK; M.J. BROWN

    2001-08-01

    Prediction of the 3-dimensional flow field around buildings and other obstacles is important for a number of applications, including urban air quality studies, the tracking of plumes from accidental releases of toxic air contaminants, indoor/outdoor air pollution problems, and thermal comfort assessments. Various types of computational fluid dynamics (CFD) models have been used for determining the flow fields around buildings (e.g., Reisner et al., 1998; Eichhorn et al., 1988). Comparisons to measurements show that these models work reasonably well for the most part (e.g., Ehrhard et al., 2 ; Johnson and Hunter, 1998; Murakami, 1997). However, CFD models are computationally intensive and for some applications turn-around time is of the essence. For example, planning and assessment studies in which hundreds of cases must be analyzed or emergency response scenarios in which plume transport must be computed quickly. Several fast-response dispersion models of varying levels of fidelity have been developed to explicitly account for the effects of a single building or groups of buildings (e.g., UDM - Hall et al. (2000), NRC-Ramsdell and Fosmire (1995), CBP-3 - Yamartino and Wiegand (1986), APRAC - Daerdt et al. (1973)). Although a few of these models include the Hotchkiss and Harlow (1973) analytical solution for potential flow in a notch to describe the velocity field within an urban canyon, in general, these models do not explicitly compute the velocity field around groups of buildings. The EPA PRIME model (Schulman et al., 2000) has been empirically derived to provide streamlines around a single isolated building.

  11. Improvements in fast-response flood modeling: desktop parallel computing and domain tracking

    SciTech Connect

    Judi, David R; Mcpherson, Timothy N; Burian, Steven J

    2009-01-01

    It is becoming increasingly important to have the ability to accurately forecast flooding, as flooding accounts for the most losses due to natural disasters in the world and the United States. Flood inundation modeling has been dominated by one-dimensional approaches. These models are computationally efficient and are considered by many engineers to produce reasonably accurate water surface profiles. However, because the profiles estimated in these models must be superimposed on digital elevation data to create a two-dimensional map, the result may be sensitive to the ability of the elevation data to capture relevant features (e.g. dikes/levees, roads, walls, etc...). Moreover, one-dimensional models do not explicitly represent the complex flow processes present in floodplains and urban environments and because two-dimensional models based on the shallow water equations have significantly greater ability to determine flow velocity and direction, the National Research Council (NRC) has recommended that two-dimensional models be used over one-dimensional models for flood inundation studies. This paper has shown that two-dimensional flood modeling computational time can be greatly reduced through the use of Java multithreading on multi-core computers which effectively provides a means for parallel computing on a desktop computer. In addition, this paper has shown that when desktop parallel computing is coupled with a domain tracking algorithm, significant computation time can be eliminated when computations are completed only on inundated cells. The drastic reduction in computational time shown here enhances the ability of two-dimensional flood inundation models to be used as a near-real time flood forecasting tool, engineering, design tool, or planning tool. Perhaps even of greater significance, the reduction in computation time makes the incorporation of risk and uncertainty/ensemble forecasting more feasible for flood inundation modeling (NRC 2000; Sayers et al

  12. Validation of a Fast-Response Urban Micrometeorological Model to Assess the Performance of Urban Heat Island Mitigation Strategies

    NASA Astrophysics Data System (ADS)

    Nadeau, D.; Girard, P.; Overby, M.; Pardyjak, E.; Stoll, R., II; Willemsen, P.; Bailey, B.; Parlange, M. B.

    2015-12-01

    Urban heat islands (UHI) are a real threat in many cities worldwide and mitigation measures have become a central component of urban planning strategies. Even within a city, causes of UHI vary from one neighborhood to another, mostly due the spatial variability in surface thermal properties, building geometry, anthropogenic heat flux releases and vegetation cover. As a result, the performance of UHI mitigation measures also varies in space. Hence, there is a need to develop a tool to quantify the efficiency of UHI mitigation measures at the neighborhood scale. The objective of this ongoing study is to validate the fast-response micrometeorological model QUIC EnvSim (QES). This model can provide all information required for UHI studies with a fine spatial resolution (up to 0.5m) and short computation time. QES combines QUIC, a CFD-based wind solver and dispersion model, and EnvSim, composed of a radiation model, a land-surface model and a turbulent transport model. Here, high-resolution (1 m) simulations are run over a subset of the École Polytechnique Fédérale de Lausanne (EPFL) campus including complex buildings, various surfaces properties and vegetation. For nearly five months in 2006-07, a dense network of meteorological observations (92 weather stations over 0.1 km2) was deployed over the campus and these unique data are used here as a validation dataset. We present validation results for different test cases (e.g., sunny vs cloudy days, different incoming wind speeds and directions) and explore the effect of a few UHI mitigation strategies on the spatial distribution of near-surface air temperatures. Preliminary results suggest that QES may be a valuable tool in decision-making regarding adaptation of urban planning to UHI.

  13. Fast and slow responses of Southern Ocean sea surface temperature to SAM in coupled climate models

    NASA Astrophysics Data System (ADS)

    Krishnamurti, T. N.; Kumar, Vinay; Simon, Anu; Thomas, Aype; Bhardwaj, Amit; Das, Sweta; Senroy, Soma; Roy Bhowmik, S. K.

    2016-06-01

    A major rain storm in Uttarakhand (India) caused heavy rains and major loss of life from floods and land slide during 16-18 June, 2013. The observed daily maximum rainfall rates (3-hourly) during the 16th and 17th June were 220 and 340 mm respectively. This event is addressed via sensitivity studies using a cloud resolving non-hydrostatic model with detailed microphysics. The streaming of moist air from the east-south-east and warmer air from the south-west contributed to the sustained large population and amplitude of buoyancy and the associated CAPE contributed to the longer period of heavy rains. This study addresses the concept of Buoyancy as a means for large vertical accelerations, stronger vertical motions, extreme rain rates and the mechanisms that relate to the time rates of change. A post-processing algorithm provides an analysis of time rate of change for the buoyancy. Moist air streams and warm/moist air intrusions into heavily raining clouds are part of this buoyancy enhancement framework. Improvements in modeling of the extreme rain event came from adaptive observational strategy that showed lack of moisture data sets in these vital regions. We show that a moist boundary layer near the Bay of Bengal leads to moist rivers of moisture where the horizontal convergence confines a large population of buoyancy elements with large magnitudes of buoyancy that streams towards the region of extreme orographic rains. The areas covered in this study include: (i) Use of high resolution cloud modeling (1-km), (ii) Now casting of rains using physical initialization with a Newtonian relaxation, (iii) Use of an adaptive observational strategy, (iii) Sensitivity of the evolution of fields and population of buoyancy elements to boundary layer moisture, (iv) Role of orography and details of buoyancy budget.

  14. The Fast-Evolving phy-2 Gene Modulates Sexual Development in Response to Light in the Model Fungus Neurospora crassa

    PubMed Central

    Wang, Zheng; Li, Ning; Li, Jigang; Dunlap, Jay C.; Trail, Frances

    2016-01-01

    ABSTRACT Rapid responses to changes in incident light are critical to the guidance of behavior and development in most species. Phytochrome light receptors in particular play key roles in bacterial physiology and plant development, but their functions and regulation are less well understood in fungi. Nevertheless, genome-wide expression measurements provide key information that can guide experiments that reveal how genes respond to environmental signals and clarify their role in development. We performed functional genomic and phenotypic analyses of the two phytochromes in Neurospora crassa, a fungal model adapted to a postfire environment that experiences dramatically variable light conditions. Expression of phy-1 and phy-2 was low in early sexual development and in the case of phy-2 increased in late sexual development. Under light stimulation, strains with the phytochromes deleted exhibited increased expression of sexual development-related genes. Moreover, under red light, the phy-2 knockout strain commenced sexual development early. In the evolution of phytochromes within ascomycetes, at least two duplications have occurred, and the faster-evolving phy-2 gene has frequently been lost. Additionally, the three key cysteine sites that are critical for bacterial and plant phytochrome function are not conserved within fungal phy-2 homologs. Through the action of phytochromes, transitions between asexual and sexual reproduction are modulated by light level and light quality, presumably as an adaptation for fast asexual growth and initiation of sexual reproduction of N. crassa in exposed postfire ecosystems. PMID:26956589

  15. Fast generation of stereolithographic models.

    PubMed

    Raic, K; Jansen, T; von Rymon-Lipinski, B; Tille, C; Seitz, H; Keeve, E

    2002-01-01

    In this paper we present a work-in-progress method for fast and efficient generation of stereolithographic models. The overall approach is embedded in our general software framework Julius, which runs on high-end-graphic systems as well as on low-level PCs. The design of the support structures needed for the stereolithographic process will allow semiautomatic generation of the model. We did produce support structures for stereolithographic models with this fast data processing pipeline and will show future perspectives in this paper. PMID:12451779

  16. Enhanced Model for Fast Ignition

    SciTech Connect

    Mason, Rodney J.

    2010-10-12

    Laser Fusion is a prime candidate for alternate energy production, capable of serving a major portion of the nation's energy needs, once fusion fuel can be readily ignited. Fast Ignition may well speed achievement of this goal, by reducing net demands on laser pulse energy and timing precision. However, Fast Ignition has presented a major challenge to modeling. This project has enhanced the computer code ePLAS for the simulation of the many specialized phenomena, which arise with Fast Ignition. The improved code has helped researchers to understand better the consequences of laser absorption, energy transport, and laser target hydrodynamics. ePLAS uses efficient implicit methods to acquire solutions for the electromagnetic fields that govern the accelerations of electrons and ions in targets. In many cases, the code implements fluid modeling for these components. These combined features, "implicitness and fluid modeling," can greatly facilitate calculations, permitting the rapid scoping and evaluation of experiments. ePLAS can be used on PCs, Macs and Linux machines, providing researchers and students with rapid results. This project has improved the treatment of electromagnetics, hydrodynamics, and atomic physics in the code. It has simplified output graphics, and provided new input that avoids the need for source code access by users. The improved code can now aid university, business and national laboratory users in pursuit of an early path to success with Fast Ignition.

  17. Physiological Responses of a Model Marine Diatom to Fast pH Changes: Special Implications of Coastal Water Acidification

    PubMed Central

    Wu, Yaping; Beardall, John; Gao, Kunshan

    2015-01-01

    Diatoms and other phytoplankton in coastal waters experience rapid pH changes in milieu due to high biological activities and/or upwelled CO2-rich waters. While CO2 concentrating mechanisms (CCMs) are employed by all diatoms tested to counter low CO2 availability in seawater, little is known how this mechanism responds to fast pH changes. In the present study, the model diatom Thalassiosira pseudonana was acclimated for 20 generations to low pH (7.81) at an elevated CO2 of 1000 μatm (HC) or to high pH (8.18) at ambient CO2 levels of 390 μatm (LC), then its physiological characteristics were investigated as cells were shifted from HC to LC or vice versa. The maximal electron transport rate (ETRmax) in the HC-acclimated cells was immediately reduced by decreased CO2 availability, showing much lower values compared to that of the LC-acclimated cells. However, the cells showed a high capacity to regain their photochemical performance regardless of the growth CO2 levels, with their ETRmax values recovering to initial levels in about 100 min. This result indicates that this diatom might modulate its CCMs quickly to maintain a steady state supply of CO2, which is required for sustaining photosynthesis. In addition, active uptake of CO2 could play a fundamental role during the induction of CCMs under CO2 limitation, since the cells maintained high ETR even when both intracellular and periplasmic carbonic anhydrases were inhibited. It is concluded that efficient regulation of the CCM is one of the key strategies for diatoms to survive in fast changing pH environment, e.g. for the tested species, which is a dominant species in coastal waters where highly fluctuating pH is observed. PMID:26496125

  18. Fast-response cup anemometer features cosine response

    NASA Technical Reports Server (NTRS)

    Frenzen, P.

    1968-01-01

    Six-cup, low-inertia anemometer combines high resolution and fast response with a unique ability to sense only the horizontal component of the winds fluctuating rapidly in three dimensions. Cup assemblies are fabricated of expanded polystyrene plastic.

  19. Noise-controlled slow-fast oscillations in predator-prey models with the Beddington functional response

    NASA Astrophysics Data System (ADS)

    Mankin, R.; Laas, T.; Soika, E.; Ainsaar, A.

    2007-09-01

    The influence of environmental fluctuations (modeled as a multiplicative dichotomous noise) on predator-prey interaction is studied using a metapopulation model with N prey-subpopulations. Investigating the role that predator interference plays in the dynamics of such trophic systems, the Beddington functional response is considered. In case the growth rates of prey and predator are widely different, we obtain analytic results by a dynamical mean-field approximation. In some regions of the system parameters, variations of noise amplitude or correlation time can cause transitions of the mean field from a globally stable equilibrium to the stable limit cycle as well as in the opposite direction. The conditions for the occurrence of such a phenomenon are found and illustrated by phase diagrams. Implications of the results on the colored-noise-induced extinction of a predator population are also discussed.

  20. RCD+: Fast loop modeling server.

    PubMed

    López-Blanco, José Ramón; Canosa-Valls, Alejandro Jesús; Li, Yaohang; Chacón, Pablo

    2016-07-01

    Modeling loops is a critical and challenging step in protein modeling and prediction. We have developed a quick online service (http://rcd.chaconlab.org) for ab initio loop modeling combining a coarse-grained conformational search with a full-atom refinement. Our original Random Coordinate Descent (RCD) loop closure algorithm has been greatly improved to enrich the sampling distribution towards near-native conformations. These improvements include a new workflow optimization, MPI-parallelization and fast backbone angle sampling based on neighbor-dependent Ramachandran probability distributions. The server starts by efficiently searching the vast conformational space from only the loop sequence information and the environment atomic coordinates. The generated closed loop models are subsequently ranked using a fast distance-orientation dependent energy filter. Top ranked loops are refined with the Rosetta energy function to obtain accurate all-atom predictions that can be interactively inspected in an user-friendly web interface. Using standard benchmarks, the average root mean squared deviation (RMSD) is 0.8 and 1.4 Å for 8 and 12 residues loops, respectively, in the challenging modeling scenario in where the side chains of the loop environment are fully remodeled. These results are not only very competitive compared to those obtained with public state of the art methods, but also they are obtained ∼10-fold faster. PMID:27151199

  1. RCD+: Fast loop modeling server

    PubMed Central

    López-Blanco, José Ramón; Canosa-Valls, Alejandro Jesús; Li, Yaohang; Chacón, Pablo

    2016-01-01

    Modeling loops is a critical and challenging step in protein modeling and prediction. We have developed a quick online service (http://rcd.chaconlab.org) for ab initio loop modeling combining a coarse-grained conformational search with a full-atom refinement. Our original Random Coordinate Descent (RCD) loop closure algorithm has been greatly improved to enrich the sampling distribution towards near-native conformations. These improvements include a new workflow optimization, MPI-parallelization and fast backbone angle sampling based on neighbor-dependent Ramachandran probability distributions. The server starts by efficiently searching the vast conformational space from only the loop sequence information and the environment atomic coordinates. The generated closed loop models are subsequently ranked using a fast distance-orientation dependent energy filter. Top ranked loops are refined with the Rosetta energy function to obtain accurate all-atom predictions that can be interactively inspected in an user-friendly web interface. Using standard benchmarks, the average root mean squared deviation (RMSD) is 0.8 and 1.4 Å for 8 and 12 residues loops, respectively, in the challenging modeling scenario in where the side chains of the loop environment are fully remodeled. These results are not only very competitive compared to those obtained with public state of the art methods, but also they are obtained ∼10-fold faster. PMID:27151199

  2. Fast transmittance model for satellite sounding

    NASA Astrophysics Data System (ADS)

    Rayer, P. J.

    1995-11-01

    Through the use of new line-by-line spectral calculations in both the infrared and microwave regions, coefficients have been generated for the transmittance stage of the fast radiative transfer model used by the United Kingdom Meteorological Office. These permit the fast model to calculate the transmittance for the high-resolution infrared sounder and the microwave sounding unit instruments aboard the National Oceanic and Atmospheric Administration polar-orbiting satellite for a given atmospheric profile, simply by taking these coefficients in linear combination with a set of predictors. These are expressed in terms of the deviation of the profile from a reference. However, the method can be applied to any instrument within the range of the spectral calculations, thereby permitting new coefficients to be calculated as soon as the spectral response details for the instrument become available. It also permits effective consideration to be given in the longer term to new line data or improvements in line-shape theory. The process by which these coefficients have been obtained is described, along with a discussion of some of the tests carried out on their installation into the fast model; these tests show that they are suitable for operational use. The predictors employed by the fast model are discussed, and changes are proposed for those that relate to the water-vapor transmittance. In this respect it was found that the inclusion of predictors that depend primarily on the zenith angle of the radiation path leads to improvements in the transmittance calculation.

  3. FAST Simulation Tool Containing Methods for Predicting the Dynamic Response of Wind Turbines

    SciTech Connect

    Jonkman, Jason

    2015-08-12

    FAST is a simulation tool (computer software) for modeling tlie dynamic response of horizontal-axis wind turbines. FAST employs a combined modal and multibody structural-dynamics formulation in the time domain.

  4. Side-welded fast response sheathed thermocouple

    DOEpatents

    Carr, Kenneth R.

    1981-01-01

    A method of fabricating the measuring junction of a grounded-junction sheathed thermocouple to obtain fast time response and good thermal cycling performance is provided. Slots are tooled or machined into the sheath wall at the measuring junction, the thermocouple wires are laser-welded into the slots. A thin metal closure cap is then laser-welded over the end of the sheath. Compared to a conventional grounded-junction thermocouple, the response time is 4-5 times faster and the thermal shock and cycling capabilities are substantially improved.

  5. Side-welded fast response sheathed thermocouple

    DOEpatents

    Carr, K.R.

    A method of fabricating the measuring junction of a grounded-junction sheathed thermocouple to obtain fast time response and good thermal cycling performance is provided. Slots are tooled or machined into the sheath wall at the measuring junction, the thermocouple wires are laser-welded into the slots. A thin metal closure cap is then laser-welded over the end of the sheath. Compared to a conventional grounded-junction thermocouple, the response time is 4 to 5 times faster and the thermal shock and cycling capabilities are substantially improved.

  6. Fast infrared response of YBCO thin films

    NASA Technical Reports Server (NTRS)

    Ballentine, P. H.; Kadin, A. M.; Donaldson, W. R.; Scofield, J. H.; Bajuk, L.

    1990-01-01

    The response to short infrared pulses of some epitaxial YBCO films prepared by sputter deposition and by electron-beam evaporation is reported. The response is found to be essentially bolometric on the ns timescale, with some indirect hints of nonequilibrium electron transport on the ps scale. Fast switching could be obtained either by biasing the switch close to the critical current or by cooling the film below about 20 K. These results are encouraging for potential application to a high-current optically-triggered opening switch.

  7. The fast debris evolution model

    NASA Astrophysics Data System (ADS)

    Lewis, H. G.; Swinerd, G. G.; Newland, R. J.; Saunders, A.

    2009-09-01

    The 'particles-in-a-box' (PIB) model introduced by Talent [Talent, D.L. Analytic model for orbital debris environmental management. J. Spacecraft Rocket, 29 (4), 508-513, 1992.] removed the need for computer-intensive Monte Carlo simulation to predict the gross characteristics of an evolving debris environment. The PIB model was described using a differential equation that allows the stability of the low Earth orbit (LEO) environment to be tested by a straightforward analysis of the equation's coefficients. As part of an ongoing research effort to investigate more efficient approaches to evolutionary modelling and to develop a suite of educational tools, a new PIB model has been developed. The model, entitled Fast Debris Evolution (FADE), employs a first-order differential equation to describe the rate at which new objects ⩾10 cm are added and removed from the environment. Whilst Talent [Talent, D.L. Analytic model for orbital debris environmental management. J. Spacecraft Rocket, 29 (4), 508-513, 1992.] based the collision theory for the PIB approach on collisions between gas particles and adopted specific values for the parameters of the model from a number of references, the form and coefficients of the FADE model equations can be inferred from the outputs of future projections produced by high-fidelity models, such as the DAMAGE model. The FADE model has been implemented as a client-side, web-based service using JavaScript embedded within a HTML document. Due to the simple nature of the algorithm, FADE can deliver the results of future projections immediately in a graphical format, with complete user-control over key simulation parameters. Historical and future projections for the ⩾10 cm LEO debris environment under a variety of different scenarios are possible, including business as usual, no future launches, post-mission disposal and remediation. A selection of results is presented with comparisons with predictions made using the DAMAGE environment model

  8. Distinguishing Fast and Slow Processes in Accuracy - Response Time Data.

    PubMed

    Coomans, Frederik; Hofman, Abe; Brinkhuis, Matthieu; van der Maas, Han L J; Maris, Gunter

    2016-01-01

    We investigate the relation between speed and accuracy within problem solving in its simplest non-trivial form. We consider tests with only two items and code the item responses in two binary variables: one indicating the response accuracy, and one indicating the response speed. Despite being a very basic setup, it enables us to study item pairs stemming from a broad range of domains such as basic arithmetic, first language learning, intelligence-related problems, and chess, with large numbers of observations for every pair of problems under consideration. We carry out a survey over a large number of such item pairs and compare three types of psychometric accuracy-response time models present in the literature: two 'one-process' models, the first of which models accuracy and response time as conditionally independent and the second of which models accuracy and response time as conditionally dependent, and a 'two-process' model which models accuracy contingent on response time. We find that the data clearly violates the restrictions imposed by both one-process models and requires additional complexity which is parsimoniously provided by the two-process model. We supplement our survey with an analysis of the erroneous responses for an example item pair and demonstrate that there are very significant differences between the types of errors in fast and slow responses. PMID:27167518

  9. Fast response dual frequency liquid crystal materials

    NASA Astrophysics Data System (ADS)

    Song, Qiong

    Dual frequency liquid crystal (DFLC) exhibits a positive dielectric anisotropy at low frequencies and negative dielectric anisotropy at high frequencies. The frequency where dielectric anisotropy is zero is called crossover frequency. DFLC can achieve fast rise time and fast decay time with the assistance of applied voltage. However, one drawback of DFLC is that it has dielectric heating effect when driven at a high frequency. Thus, the first part of this dissertation is to develop low crossover frequency DFLC materials. The dielectric relaxation and physical properties of some single- and double-ester compounds were investigated. Experimental results indicate that the double-ester compound exhibits a ˜3X lower dielectric relaxation frequencies and larger dielectric anisotropy than the single ester, but its viscosity is also higher. More generally, ten groups of dual frequency liquid crystals were compared in terms of dielectric relaxation frequency and dielectric anisotropy. The dielectric relaxation theory was discussed at last. To realize fast response time, high birefringence and low viscosity LC are required. From these two aspects, firstly four new high birefringence laterally difluoro phenyl tolane liquid crystals with a negative dielectric anisotropy were studied. These materials are used to enhance the birefringence of DFLC. They have a fairly small heat fusion enthalpy (˜3000 cal/mol) which improves their solubility in a host. We dope 10 wt% of each compound into a commercial negative mixture N1 and measured their birefringence, viscoelastic constant and figure of merit. Birefringence varies very little among homologues while viscoelastic constant increases as alkyl chain length increases. Secondly, we studied the effects of six diluters for lowering the viscosity while stabilizing the vertical alignment (VA) of the laterally difluoro terphenyl host mixture at elevated temperatures. The pros and cons of each diluter are analyzed. These lateral difluoro

  10. Probing Planetary Bodies for Subsurface Volatiles: GEANT4 Models of Gamma Ray, Fast, Epithermal, and Thermal Neutron Response to Active Neutron Illumination

    NASA Astrophysics Data System (ADS)

    Chin, G.; Sagdeev, R.; Su, J. J.; Murray, J.

    2014-12-01

    Using an active source of neutrons as an in situ probe of a planetary body has proven to be a powerful tool to extract information about the presence, abundance, and location of subsurface volatiles without the need for drilling. The Dynamic Albedo of Neutrons (DAN) instrument on Curiosity is an example of such an instrument and is designed to detect the location and abundance of hydrogen within the top 50 cm of the Martian surface. DAN works by sending a pulse of neutrons towards the ground beneath the rover and detecting the reflected neutrons. The intensity and time of arrival of the reflection depends on the proportion of water, while the time the pulse takes to reach the detector is a function of the depth at which the water is located. Similar instruments can also be effective probes at the polar-regions of the Moon or on asteroids as a way of detecting sequestered volatiles. We present the results of GEANT4 particle simulation models of gamma ray, fast, epithermal, and thermal neutron responses to active neutron illumination. The results are parameterized by hydrogen abundance, stratification and depth of volatile layers, versus the distribution of neutron and gamma ray energy reflections. Models will be presented to approximate Martian, lunar, and asteroid environments and would be useful tools to assess utility for future NASA exploration missions to these types of planetary bodies.

  11. Fast response to human voices in autism

    PubMed Central

    Lin, I-Fan; Agus, Trevor R.; Suied, Clara; Pressnitzer, Daniel; Yamada, Takashi; Komine, Yoko; Kato, Nobumasa; Kashino, Makio

    2016-01-01

    Individuals with autism spectrum disorders (ASD) are reported to allocate less spontaneous attention to voices. Here, we investigated how vocal sounds are processed in ASD adults, when those sounds are attended. Participants were asked to react as fast as possible to target stimuli (either voices or strings) while ignoring distracting stimuli. Response times (RTs) were measured. Results showed that, similar to neurotypical (NT) adults, ASD adults were faster to recognize voices compared to strings. Surprisingly, ASD adults had even shorter RTs for voices than the NT adults, suggesting a faster voice recognition process. To investigate the acoustic underpinnings of this effect, we created auditory chimeras that retained only the temporal or the spectral features of voices. For the NT group, no RT advantage was found for the chimeras compared to strings: both sets of features had to be present to observe an RT advantage. However, for the ASD group, shorter RTs were observed for both chimeras. These observations indicate that the previously observed attentional deficit to voices in ASD individuals could be due to a failure to combine acoustic features, even though such features may be well represented at a sensory level. PMID:27193919

  12. Fast response to human voices in autism.

    PubMed

    Lin, I-Fan; Agus, Trevor R; Suied, Clara; Pressnitzer, Daniel; Yamada, Takashi; Komine, Yoko; Kato, Nobumasa; Kashino, Makio

    2016-05-19

    Individuals with autism spectrum disorders (ASD) are reported to allocate less spontaneous attention to voices. Here, we investigated how vocal sounds are processed in ASD adults, when those sounds are attended. Participants were asked to react as fast as possible to target stimuli (either voices or strings) while ignoring distracting stimuli. Response times (RTs) were measured. Results showed that, similar to neurotypical (NT) adults, ASD adults were faster to recognize voices compared to strings. Surprisingly, ASD adults had even shorter RTs for voices than the NT adults, suggesting a faster voice recognition process. To investigate the acoustic underpinnings of this effect, we created auditory chimeras that retained only the temporal or the spectral features of voices. For the NT group, no RT advantage was found for the chimeras compared to strings: both sets of features had to be present to observe an RT advantage. However, for the ASD group, shorter RTs were observed for both chimeras. These observations indicate that the previously observed attentional deficit to voices in ASD individuals could be due to a failure to combine acoustic features, even though such features may be well represented at a sensory level.

  13. A model for fast axonal transport.

    PubMed

    Blum, J J; Reed, M C

    1985-01-01

    A model for fast axonal transport is developed in which the essential features are that organelles may interact with mechanochemical cross-bridges that in turn interact with microtubules, forming an organelle-engine-microtubule complex which is transported along the microtubules. Computer analysis of the equations derived to describe such a system show that most of the experimental observations on fast axonal transport can be simulated by the model, indicating that the model is useful for the interpretation and design of experiments aimed at clarifying the mechanism of fast axonal transport. PMID:2416456

  14. Modeling the response of a fast ion loss detector using orbit tracing techniques in a neutral beam prompt-loss study on the DIII-D tokamak

    SciTech Connect

    Pace, D. C.; Heidbrink, W. W.; Muscatello, C. M.; Zhu, Y. B.; Fisher, R. K.; Van Zeeland, M. A.; Garcia-Munoz, M.; Darrow, D. S.; Nazikian, R.

    2010-10-15

    A numerical model describing the expected measurements of neutral beam prompt-losses by a newly commissioned fast ion loss detector (FILD) in DIII-D is presented. This model incorporates the well understood neutral beam deposition profiles from all eight DIII-D beamlines to construct a prompt-loss source distribution. The full range of detectable ion orbit phase space available to the FILD is used to calculate ion trajectories that overlap with neutral beam injection footprints. Weight functions are applied to account for the level of overlap between these detectable orbits and the spatial and velocity (pitch) properties of ionized beam neutrals. An experimental comparison is performed by firing each neutral beam individually in the presence of a ramping plasma current. Fast ion losses determined from the model are in agreement with measured losses.

  15. Modeling the response of a fast ion loss detector using orbit tracing techniques in a neutral beam prompt-loss study on the DIII-D tokamak.

    PubMed

    Pace, D C; Fisher, R K; García-Muñoz, M; Darrow, D S; Heidbrink, W W; Muscatello, C M; Nazikian, R; Van Zeeland, M A; Zhu, Y B

    2010-10-01

    A numerical model describing the expected measurements of neutral beam prompt-losses by a newly commissioned fast ion loss detector (FILD) in DIII-D is presented. This model incorporates the well understood neutral beam deposition profiles from all eight DIII-D beamlines to construct a prompt-loss source distribution. The full range of detectable ion orbit phase space available to the FILD is used to calculate ion trajectories that overlap with neutral beam injection footprints. Weight functions are applied to account for the level of overlap between these detectable orbits and the spatial and velocity (pitch) properties of ionized beam neutrals. An experimental comparison is performed by firing each neutral beam individually in the presence of a ramping plasma current. Fast ion losses determined from the model are in agreement with measured losses.

  16. Analytical model for fast-shock ignition

    NASA Astrophysics Data System (ADS)

    Ghasemi, S. A.; Farahbod, A. H.; Sobhanian, S.

    2014-07-01

    A model and its improvements are introduced for a recently proposed approach to inertial confinement fusion, called fast-shock ignition (FSI). The analysis is based upon the gain models of fast ignition, shock ignition and considerations for the fast electrons penetration into the pre-compressed fuel to examine the formation of an effective central hot spot. Calculations of fast electrons penetration into the dense fuel show that if the initial electron kinetic energy is of the order ˜4.5 MeV, the electrons effectively reach the central part of the fuel. To evaluate more realistically the performance of FSI approach, we have used a quasi-two temperature electron energy distribution function of Strozzi (2012) and fast ignitor energy formula of Bellei (2013) that are consistent with 3D PIC simulations for different values of fast ignitor laser wavelength and coupling efficiency. The general advantages of fast-shock ignition in comparison with the shock ignition can be estimated to be better than 1.3 and it is seen that the best results can be obtained for the fuel mass around 1.5 mg, fast ignitor laser wavelength ˜0.3 micron and the shock ignitor energy weight factor about 0.25.

  17. Analytical model for fast-shock ignition

    SciTech Connect

    Ghasemi, S. A. Farahbod, A. H.; Sobhanian, S.

    2014-07-15

    A model and its improvements are introduced for a recently proposed approach to inertial confinement fusion, called fast-shock ignition (FSI). The analysis is based upon the gain models of fast ignition, shock ignition and considerations for the fast electrons penetration into the pre-compressed fuel to examine the formation of an effective central hot spot. Calculations of fast electrons penetration into the dense fuel show that if the initial electron kinetic energy is of the order ∼4.5 MeV, the electrons effectively reach the central part of the fuel. To evaluate more realistically the performance of FSI approach, we have used a quasi-two temperature electron energy distribution function of Strozzi (2012) and fast ignitor energy formula of Bellei (2013) that are consistent with 3D PIC simulations for different values of fast ignitor laser wavelength and coupling efficiency. The general advantages of fast-shock ignition in comparison with the shock ignition can be estimated to be better than 1.3 and it is seen that the best results can be obtained for the fuel mass around 1.5 mg, fast ignitor laser wavelength ∼0.3  micron and the shock ignitor energy weight factor about 0.25.

  18. Evidence of Effective Early Numeracy Models. CEELO FastFacts

    ERIC Educational Resources Information Center

    Schilder, D.

    2014-01-01

    In this "Fast Facts," a state requested information on supporting districts' use of effective models and approaches to improve children's early literacy and numeracy outcomes. In response, Center on Enhancing Early Learning Outcomes (CEELO) staff reviewed key research including information from the What Works Clearinghouse obtained by…

  19. Fast Electromechanical Response in Liquid Crystal Elastomer Nanocomposites

    NASA Astrophysics Data System (ADS)

    Verduzco, Rafael; Agrawal, Aditya; Jacot, Jeff; Adetiba, Tomi

    2014-03-01

    Liquid crystal elastomers (LCEs) combine the elasticity of polymer networks with the fluidity and responsiveness of liquid crystals. LCEs can respond to a variety of external stimuli - heat, light, electric and magnetic fields - with large and reversible shape-changes. However, the response can be slow and/or require large external fields. Here, we present our recent work with LCE bilayers and LCE composite materials that demonstrates LCEs can respond quickly and with 3-D shape changes. Nematic LCE bilayers are prepared by depositing a PS film on top of a nematic LCE, and the bilayers exhibit reversible wrinkling, folding, and curling with temperature. The shape change of LCE bilayers is quantitatively predicted using finite-element modeling. Next, we show that a fast response to an electric field is achieved in nematic LCE composites. While typical nematic LCEs are relatively unresponsive to electric fields, LCE composites with 2 wt % carbon black can reversibly contract and expand in response to a 40 V electric field. The response time (0.1 - 10 Hz) and amplitude of shape change (1 - 20 %) depends on the external field and carbon black content. These composites may be useful for biomedical applications, such as substrates for dynamic cell culture and biocompatible scaffolds for heart tissue regeneration. Neonatal rat ventricular myocytes remain viable on LCE-carbon black bilayer substrates, and aligned myocyte cell sheets were successfully grown on LCE-composite bilayers.

  20. Fast and Slow Precipitation Responses to Individual Climate Forcers: A PDRMIP Multimodel Study

    NASA Technical Reports Server (NTRS)

    Samset, B. H.; Myhre, G.; Forster, P.M.; Hodnebrog, O.; Andrews, T.; Faluvegi, G.; Flaschner, D.; Kasoar, M.; Kharin, V.; Kirkevag, A.; Shindell, D.; Voulgarakis, A.

    2016-01-01

    Precipitation is expected to respond differently to various drivers of anthropogenic climate change. We present the first results from the Precipitation Driver and Response Model Intercomparison Project (PDRMIP), where nine global climate models have perturbed CO2, CH4, black carbon, sulfate, and solar insolation. We divide the resulting changes to global mean and regional precipitation into fast responses that scale with changes in atmospheric absorption and slow responses scaling with surface temperature change. While the overall features are broadly similar between models, we find significant regional intermodel variability, especially over land. Black carbon stands out as a component that may cause significant model diversity in predicted precipitation change. Processes linked to atmospheric absorption are less consistently modeled than those linked to top-of-atmosphere radiative forcing. We identify a number of land regions where the model ensemble consistently predicts that fast precipitation responses to climate perturbations dominate over the slow, temperature-driven responses.

  1. A fast hidden line algorithm for plotting finite element models

    NASA Technical Reports Server (NTRS)

    Jones, G. K.

    1982-01-01

    Effective plotting of finite element models requires the use of fast hidden line plot techniques that provide interactive response. A high speed hidden line technique was developed to facilitate the plotting of NASTRAN finite element models. Based on testing using 14 different models, the new hidden line algorithm (JONES-D) appears to be very fast: its speed equals that for normal (all lines visible) plotting and when compared to other existing methods it appears to be substantially faster. It also appears to be very reliable: no plot errors were observed using the new method to plot NASTRAN models. The new algorithm was made part of the NPLOT NASTRAN plot package and was used by structural analysts for normal production tasks.

  2. Application of Model Based Parameter Estimation for Fast Frequency Response Calculations of Input Characteristics of Cavity-Backed Aperture Antennas Using Hybrid FEM/MoM Technique

    NASA Technical Reports Server (NTRS)

    Reddy C. J.

    1998-01-01

    Model Based Parameter Estimation (MBPE) is presented in conjunction with the hybrid Finite Element Method (FEM)/Method of Moments (MoM) technique for fast computation of the input characteristics of cavity-backed aperture antennas over a frequency range. The hybrid FENI/MoM technique is used to form an integro-partial- differential equation to compute the electric field distribution of a cavity-backed aperture antenna. In MBPE, the electric field is expanded in a rational function of two polynomials. The coefficients of the rational function are obtained using the frequency derivatives of the integro-partial-differential equation formed by the hybrid FEM/ MoM technique. Using the rational function approximation, the electric field is obtained over a frequency range. Using the electric field at different frequencies, the input characteristics of the antenna are obtained over a wide frequency range. Numerical results for an open coaxial line, probe-fed coaxial cavity and cavity-backed microstrip patch antennas are presented. Good agreement between MBPE and the solutions over individual frequencies is observed.

  3. Evaluation of Fast-Time Wake Vortex Prediction Models

    NASA Technical Reports Server (NTRS)

    Proctor, Fred H.; Hamilton, David W.

    2009-01-01

    Current fast-time wake models are reviewed and three basic types are defined. Predictions from several of the fast-time models are compared. Previous statistical evaluations of the APA-Sarpkaya and D2P fast-time models are discussed. Root Mean Square errors between fast-time model predictions and Lidar wake measurements are examined for a 24 hr period at Denver International Airport. Shortcomings in current methodology for evaluating wake errors are also discussed.

  4. Fast Vegetational Responses to Late-Glacial Climate Change

    NASA Astrophysics Data System (ADS)

    Williams, J. W.; Post, D. M.; Cwynar, L. C.; Lotter, A. F.; Levesque, A. J.

    2001-12-01

    How rapidly can natural ecosystems respond to rapid climate change? This question can be addressed by studying paired paleoecological and paleoclimatological records spanning the last deglaciation. Between 16 and 10 ka, abrupt climatic oscillations (e.g. Younger Dryas, Gerzensee/Killarney Oscillations) interrupted the general warming trend. Rates of climate change during these events were as fast or faster than projected rates of change for this century. We compiled a dozen high-resolution lacustrine records in North America and Europe with a pollen record and independent climatic proxy, a clear Younger Dryas signal, and good age control. Cross-correlation analysis suggests that vegetation responded rapidly to late-glacial climate change, with significant changes in vegetation composition occurring within the lifespan of individual trees. At all sites, vegetation lagged climate by less than 200 years, and at two-thirds of the sites, the initial vegetational response occurred within 100 years. The finding of rapid vegetational responses is consistent across sites and continents, and is similar to the 100-200 year response times predicted by gap-scale forest models. Likely mechanisms include 1) increased susceptibility of mature trees to disturbances such as fire, wind, and disease, thereby opening up gaps for colonization, 2) the proximity of these sites to late-glacial treeline, where climate may directly control plant population densities and range limits, 3) the presence of herbaceous taxa with short generation times in these plant communities, and 4) rapid migration due to rare long-distance seed dispersals. Our results are consistent with reports that plant ranges are already shifting in response to recent climate change, and suggest that these shifts will persist for the next several centuries. Widespread changes in plant distributions may affect surface-atmosphere interactions and will challenge attempts to manage ecosystems and conserve biodiversity.

  5. Fast-response frequency-to-analog converter

    NASA Technical Reports Server (NTRS)

    Hagihara, F. S.

    1967-01-01

    Frequency-to-analog converter has a fast response time and a low ripple. The circuit uses a frequency-to-pulse converter which provides two pulse trains, both at the same frequency as that of the input signal, but with a 10 microsecond difference between the trains.

  6. Portion sizes and obesity: responses of fast-food companies.

    PubMed

    Young, Lisa R; Nestle, Marion

    2007-07-01

    Because the sizes of food portions, especially of fast food, have increased in parallel with rising rates of overweight, health authorities have called on fast-food chains to decrease the sizes of menu items. From 2002 to 2006, we examined responses of fast-food chains to such calls by determining the current sizes of sodas, French fries, and hamburgers at three leading chains and comparing them to sizes observed in 1998 and 2002. Although McDonald's recently phased out its largest offerings, current items are similar to 1998 sizes and greatly exceed those offered when the company opened in 1955. Burger King and Wendy's have increased portion sizes, even while health authorities are calling for portion size reductions. Fast-food portions in the United States are larger than in Europe. These observations suggest that voluntary efforts by fast-food companies to reduce portion sizes are unlikely to be effective, and that policy approaches are needed to reduce energy intake from fast food. PMID:17585324

  7. Resist profile simulation with fast lithography model

    NASA Astrophysics Data System (ADS)

    He, Yan-Ying; Chou, Chih-Shiang; Tang, Yu-Po; Huang, Wen-Chun; Liu, Ru-Gun; Gau, Tsai-Sheng

    2014-03-01

    A traditional approach to construct a fast lithographic model is to match wafer top-down SEM images, contours and/or gauge CDs with a TCC model plus some simple resist representation. This modeling method has been proven and is extensively used for OPC modeling. As the technology moves forward, this traditional approach has become insufficient in regard to lithography weak point detection, etching bias prediction, etc. The drawback of this approach is from metrology and simulation. First, top-down SEM is only good for acquiring planar CD information. Some 3D metrology such as cross-section SEM or AFM is necessary to obtain the true resist profile. Second, the TCC modeling approach is only suitable for planar image simulation. In order to model the resist profile, full 3D image simulation is needed. Even though there are many rigorous simulators capable of catching the resist profile very well, none of them is feasible for full-chip application due to the tremendous consumption of computational resource. The authors have proposed a quasi-3D image simulation method in the previous study [1], which is suitable for full-chip simulation with the consideration of sidewall angles, to improve the model accuracy of planar models. In this paper, the quasi-3D image simulation is extended to directly model the resist profile with AFM and/or cross-section SEM data. Resist weak points detected by the model generated with this 3D approach are verified on the wafer.

  8. Fast odor learning improves reliability of odor responses in the locust antennal lobe.

    PubMed

    Bazhenov, Maxim; Stopfer, Mark; Sejnowski, Terrence J; Laurent, Gilles

    2005-05-01

    Recordings in the locust antennal lobe (AL) reveal activity-dependent, stimulus-specific changes in projection neuron (PN) and local neuron response patterns over repeated odor trials. During the first few trials, PN response intensity decreases, while spike time precision increases, and coherent oscillations, absent at first, quickly emerge. We examined this "fast odor learning" with a realistic computational model of the AL. Activity-dependent facilitation of AL inhibitory synapses was sufficient to simulate physiological recordings of fast learning. In addition, in experiments with noisy inputs, a network including synaptic facilitation of both inhibition and excitation responded with reliable spatiotemporal patterns from trial to trial despite the noise. A network lacking fast plasticity, however, responded with patterns that varied across trials, reflecting the input variability. Thus, our study suggests that fast olfactory learning results from stimulus-specific, activity-dependent synaptic facilitation and may improve the signal-to-noise ratio for repeatedly encountered odor stimuli.

  9. Response time characterization of fast responding pressure-sensitive paint

    NASA Astrophysics Data System (ADS)

    Ozaki, Tatsuya; Ishikawa, Hitoshi; Sakaue, Hirotaka

    2010-11-01

    Response time characterization of a fast responding pressure-sensitive paint (PSP) is important information in measuring an unsteady flow field. PSP is an optical pressure sensor. The luminescent image from the PSP is related to a pressure map. In the previous works, a time delay from a step change of pressure is generally used to characterize the response time. The thickness of the PSP as well as the PSP binding material greatly influences the response time. Because the temperature influences the diffusion or permeation of a PSP binder, it is also an important parameter to influence the response time. We build a shock tube to create a step change of pressure for response time characterization. This can control the temperature of the PSP. We discuss the PSP response times related to the temperature of the binder as well as the binding materials.

  10. Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change.

    PubMed

    Schlögl, Mathias; Piaggi, Paolo; Pannacciuli, Nicola; Bonfiglio, Susan M; Krakoff, Jonathan; Thearle, Marie S

    2015-11-01

    Because it is unknown whether 24-h energy expenditure (EE) responses to dietary extremes will identify phenotypes associated with weight regulation, the aim of this study was to determine whether such responses to fasting or overfeeding are associated with future weight change. The 24-h EE during energy balance, fasting, and four different overfeeding diets with 200% energy requirements was measured in a metabolic chamber in 37 subjects with normal glucose regulation while they resided on our clinical research unit. Diets were given for 24 h each and included the following: (1) low protein (3%), (2) standard (50% carbohydrate, 20% protein), (3) high fat (60%), and (4) high carbohydrate (75%). Participants returned for follow-up 6 months after the initial measures. The decrease in 24-h EE during fasting and the increase with overfeeding were correlated. A larger reduction in EE during fasting, a smaller EE response to low-protein overfeeding, and a larger response to high-carbohydrate overfeeding all correlated with weight gain. The association of the fasting EE response with weight change was not independent from that of low protein in a multivariate model. We identified the following two independent propensities associated with weight gain: a predilection for conserving energy during caloric and protein deprivation and a profligate response to large amounts of carbohydrates.

  11. Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change.

    PubMed

    Schlögl, Mathias; Piaggi, Paolo; Pannacciuli, Nicola; Bonfiglio, Susan M; Krakoff, Jonathan; Thearle, Marie S

    2015-11-01

    Because it is unknown whether 24-h energy expenditure (EE) responses to dietary extremes will identify phenotypes associated with weight regulation, the aim of this study was to determine whether such responses to fasting or overfeeding are associated with future weight change. The 24-h EE during energy balance, fasting, and four different overfeeding diets with 200% energy requirements was measured in a metabolic chamber in 37 subjects with normal glucose regulation while they resided on our clinical research unit. Diets were given for 24 h each and included the following: (1) low protein (3%), (2) standard (50% carbohydrate, 20% protein), (3) high fat (60%), and (4) high carbohydrate (75%). Participants returned for follow-up 6 months after the initial measures. The decrease in 24-h EE during fasting and the increase with overfeeding were correlated. A larger reduction in EE during fasting, a smaller EE response to low-protein overfeeding, and a larger response to high-carbohydrate overfeeding all correlated with weight gain. The association of the fasting EE response with weight change was not independent from that of low protein in a multivariate model. We identified the following two independent propensities associated with weight gain: a predilection for conserving energy during caloric and protein deprivation and a profligate response to large amounts of carbohydrates. PMID:26185280

  12. Fast response pyroelectric detector-preamplifier assembled device

    NASA Astrophysics Data System (ADS)

    Bai, PiJi; Tai, Yunjian; Liu, Huiping

    2008-03-01

    The pyroelectric detector is wide used for its simple structure and high performance to price ratio. It has been used in thermal detecting, infrared spectrum and laser testing. When the pyroelectric detector was applied in practice, fast reponse speed is need. For improving the response speed of the pyroelectric detector some specific technology has been used in the preamplifier schematic. High sense and fast response character of the pyroelectric detector-preamplifier assembled device had been achieved. When the device is applied in acute concussion condition, it must survive from the acute concussion condition testing. For it reliability some specific technology was used in the device fabricating procedure. At last the performance parameter testing result and simulation application condition result given in this paper show the performance of the pyroelectric detector-preamplifier assembled device had achieved the advance goal.

  13. A fast and flexible reactor physics model for simulating neutron spectra and depletion in fast reactors

    NASA Astrophysics Data System (ADS)

    Recktenwald, Geoff; Deinert, Mark

    2010-03-01

    Determining the time dependent concentration of isotopes within a nuclear reactor core is central to the analysis of nuclear fuel cycles. We present a fast, flexible tool for determining the time dependent neutron spectrum within fast reactors. The code (VBUDS: visualization, burnup, depletion and spectra) uses a two region, multigroup collision probability model to simulate the energy dependent neutron flux and tracks the buildup and burnout of 24 actinides, as well as fission products. While originally developed for LWR simulations, the model is shown to produce fast reactor spectra that show high degree of fidelity to available fast reactor benchmarks.

  14. Quark nova model for fast radio bursts

    NASA Astrophysics Data System (ADS)

    Shand, Zachary; Ouyed, Amir; Koning, Nico; Ouyed, Rachid

    2016-05-01

    Fast radio bursts (FRBs) are puzzling, millisecond, energetic radio transients with no discernible source; observations show no counterparts in other frequency bands. The birth of a quark star from a parent neutron star experiencing a quark nova - previously thought undetectable when born in isolation - provides a natural explanation for the emission characteristics of FRBs. The generation of unstable r-process elements in the quark nova ejecta provides millisecond exponential injection of electrons into the surrounding strong magnetic field at the parent neutron star's light cylinder via β-decay. This radio synchrotron emission has a total duration of hundreds of milliseconds and matches the observed spectrum while reducing the inferred dispersion measure by approximately 200 cm‑3 pc. The model allows indirect measurement of neutron star magnetic fields and periods in addition to providing astronomical measurements of β-decay chains of unstable neutron rich nuclei. Using this model, we can calculate expected FRB average energies (˜ 1041 erg) and spectral shapes, and provide a theoretical framework for determining distances.

  15. Quark nova model for fast radio bursts

    NASA Astrophysics Data System (ADS)

    Shand, Zachary; Ouyed, Amir; Koning, Nico; Ouyed, Rachid

    2016-05-01

    Fast radio bursts (FRBs) are puzzling, millisecond, energetic radio transients with no discernible source; observations show no counterparts in other frequency bands. The birth of a quark star from a parent neutron star experiencing a quark nova - previously thought undetectable when born in isolation - provides a natural explanation for the emission characteristics of FRBs. The generation of unstable r-process elements in the quark nova ejecta provides millisecond exponential injection of electrons into the surrounding strong magnetic field at the parent neutron star's light cylinder via β-decay. This radio synchrotron emission has a total duration of hundreds of milliseconds and matches the observed spectrum while reducing the inferred dispersion measure by approximately 200 cm‑3 pc. The model allows indirect measurement of neutron star magnetic fields and periods in addition to providing astronomical measurements of β-decay chains of unstable neutron rich nuclei. Using this model, we can calculate expected FRB average energies (∼ 1041 erg) and spectral shapes, and provide a theoretical framework for determining distances.

  16. A surface ice module for wind turbine dynamic response simulation using FAST

    DOE PAGES

    Yu, Bingbin; Karr, Dale G.; Song, Huimin; Sirnivas, Senu

    2016-06-03

    It is a fact that developing offshore wind energy has become more and more serious worldwide in recent years. Many of the promising offshore wind farm locations are in cold regions that may have ice cover during wintertime. The challenge of possible ice loads on offshore wind turbines raises the demand of modeling capacity of dynamic wind turbine response under the joint action of ice, wind, wave, and current. The simulation software FAST is an open source computer-aided engineering (CAE) package maintained by the National Renewable Energy Laboratory. In this paper, a new module of FAST for assessing the dynamicmore » response of offshore wind turbines subjected to ice forcing is presented. In the ice module, several models are presented which involve both prescribed forcing and coupled response. For conditions in which the ice forcing is essentially decoupled from the structural response, ice forces are established from existing models for brittle and ductile ice failure. For conditions in which the ice failure and the structural response are coupled, such as lock-in conditions, a rate-dependent ice model is described, which is developed in conjunction with a new modularization framework for FAST. In this paper, analytical ice mechanics models are presented that incorporate ice floe forcing, deformation, and failure. For lower speeds, forces slowly build until the ice strength is reached and ice fails resulting in a quasi-static condition. For intermediate speeds, the ice failure can be coupled with the structural response and resulting in coinciding periods of the ice failure and the structural response. A third regime occurs at high speeds of encounter in which brittle fracturing of the ice feature occurs in a random pattern, which results in a random vibration excitation of the structure. An example wind turbine response is simulated under ice loading of each of the presented models. This module adds to FAST the capabilities for analyzing the response of wind

  17. Advances in Fast Response Acoustically Derived Air Temperature Measurements

    NASA Astrophysics Data System (ADS)

    Bogoev, Ivan; Jacobsen, Larry; Horst, Thomas; Conrad, Benjamin

    2016-04-01

    Fast-response accurate air-temperature measurements are required when estimating turbulent fluxes of heat, water and carbon dioxide by open-path eddy-covariance technique. In comparison with contact thermometers like thermocouples, ultra-sonic thermometers do not suffer from solar radiation loading, water vapor condensation and evaporative cooling effects. Consequently they have the potential to provide more accurate true air temperature measurements. The absolute accuracy of the ultrasonic thermometer is limited by the following parameters: the distance between the transducer pairs, transducer delays associated with the electrical-acoustic signal conversion that vary with temperature, components of the wind vector that are normal to the ultrasonic paths, and humidity. The distance between the transducer pairs is commonly obtained by coordinate measuring machine. Improved accuracy demonstrated in this study results from increased stiffness in the anemometer head to better maintain the ultrasonic path-length distances. To further improve accuracy and account for changes in transducer delays and distance as a function of temperature, these parameters are characterized in a zero-wind chamber over the entire operating temperature range. When the sonic anemometer is combined with a co-located fast-response water vapor analyzer, like in the IRGASON instrument, speed of sound can be compensated for humidity effects on a point-by-point basis resulting in a true fast-response air temperature measurement. Laboratory test results show that when the above steps are implemented in the calibration of the ultrasonic thermometer air-temperature accuracy better than ±0.5 degrees Celsius can be achieved over the entire operating range. The approach is also validated in a field inter-comparison with an aspirated thermistor probe mounted in a radiation shield.

  18. A dynamical model of Kara Sea land-fast ice

    NASA Astrophysics Data System (ADS)

    Olason, Einar

    2016-05-01

    This paper introduces modifications to the traditional viscous-plastic sea-ice dynamical model, which are necessary to model land-fast ice in the Kara Sea in a realistic manner. The most important modifications are an increase in the maximum viscosity from the standard value of ζmax=>(2.5×108s>)P to ζmax=>(1013s>)P, and to use a solver for the momentum equation capable of correctly solving for small ice velocities (the limit here is set to 10-4 m/s). Given these modifications, a necessary condition for a realistic fast-ice simulation is that the yield curve give sufficient uniaxial compressive strength. This is consistent with the idea that land-fast ice in the Kara Sea forms primarily via static arching. The modified model is tested and tuned using forcing data and observations from 1997 and 1998. The results show that it is possible to model land-fast ice using this model with the modifications mentioned above. The model performs well in terms of modeled fast-ice extent, but suffers from unrealistic break-ups during the start and end of the fast-ice season. The main results are that fast ice in the Kara Sea is supported by arching of the ice, the arches footers resting on a chain of islands off shore.

  19. Response of reverse convection to fast IMF transitions

    NASA Astrophysics Data System (ADS)

    Taguchi, S.; Tawara, A.; Hairston, M. R.; Slavin, J. A.; Le, G.; Matzka, J.; Stolle, C.

    2015-05-01

    The nature of the transition that high-latitude reverse convection makes in response to fast interplanetary magnetic field (IMF) changes is investigated using observations from multiple spacecraft and a ground magnetometer array. We focused on two fast IMF-transition events on 22 April 2006. Immediately after the first event, three ST5 spacecraft identified a clear change in the distribution of the polar cap field-aligned current. Coordinate observations with the Greenland magnetometer chain showed that the near-noon Hall current distribution, which is closely related to the polar cap field-aligned current or reverse convection, was in a transition state for about 10 min. For the second event, the Greenland magnetic perturbations also showed that a transition state occurred in the near-noon sector for 10-15 min. Three DMSP spacecraft that traversed the polar cap provided evidence showing that variations of the ground magnetic perturbations were produced by the transition from clockwise plasma circulation to the anticlockwise circulation over the polar cap. A simple calculation based on the Biot-Savart law shows that the near-noon transition state is consistent with the approach of a new convection region to the near-noon sector at the speed of 0.5-1 km s-1, which is coupled with the moving away of the old convection region at a similar speed. For the higher-latitude sunward flow region, it is found that the convection takes a transition state almost simultaneously (within 1 min) with that in the near-noon sector, i.e., quasi-instantaneous response.

  20. Fast and Slow Responses of the South Asian Monsoon System to Anthropogenic Aerosols

    SciTech Connect

    Ganguly, Dilip; Rasch, Philip J.; Wang, Hailong; Yoon, Jin-Ho

    2012-09-25

    Using a global climate model with fully predictive aerosol life cycle, we investigate the fast and slow responses of the South Asian monsoon system to anthropogenic aerosol forcing. Our results show that the feedbacks associated with sea surface temperature (SST) change caused by aerosols play a more important role than the aerosol's direct impact on radiation, clouds and land surface (rapid adjustments) in shaping the total equilibrium climate response of the monsoon system to aerosol forcing. Inhomogeneous SST cooling caused by anthropogenic aerosols eventually reduces the meridional tropospheric temperature gradient and the easterly shear of zonal winds over the region, slowing down the local Hadley cell circulation, decreasing the northward moisture transport, and causing a reduction in precipitation over South Asia. Although total responses in precipitation are closer to the slow responses in general, the fast component dominates over land areas north of 25°N. Our results also show an east-west asymmetry in the fast responses to anthropogenic aerosols causing increases in precipitation west of 80°E but decreases east of it.

  1. Fast-Response-Time Shape-Memory-Effect Foam Actuators

    NASA Technical Reports Server (NTRS)

    Jardine, Peter

    2010-01-01

    Bulk shape memory alloys, such as Nitinol or CuAlZn, display strong recovery forces undergoing a phase transformation after being strained in their martensitic state. These recovery forces are used for actuation. As the phase transformation is thermally driven, the response time of the actuation can be slow, as the heat must be passively inserted or removed from the alloy. Shape memory alloy TiNi torque tubes have been investigated for at least 20 years and have demonstrated high actuation forces [3,000 in.-lb (approximately equal to 340 N-m) torques] and are very lightweight. However, they are not easy to attach to existing structures. Adhesives will fail in shear at low-torque loads and the TiNi is not weldable, so that mechanical crimp fits have been generally used. These are not reliable, especially in vibratory environments. The TiNi is also slow to heat up, as it can only be heated indirectly using heater and cooling must be done passively. This has restricted their use to on-off actuators where cycle times of approximately one minute is acceptable. Self-propagating high-temperature synthesis (SHS) has been used in the past to make porous TiNi metal foams. Shape Change Technologies has been able to train SHS derived TiNi to exhibit the shape memory effect. As it is an open-celled material, fast response times were observed when the material was heated using hot and cold fluids. A methodology was developed to make the open-celled porous TiNi foams as a tube with integrated hexagonal ends, which then becomes a torsional actuator with fast response times. Under processing developed independently, researchers were able to verify torques of 84 in.-lb (approximately equal to 9.5 Nm) using an actuator weighing 1.3 oz (approximately equal to 37 g) with very fast (less than 1/16th of a second) initial response times when hot and cold fluids were used to facilitate heat transfer. Integrated structural connections were added as part of the net shape process, eliminating

  2. EGR Control for Emisson Reduction Using Fast Response Sensors - Phase 1A

    SciTech Connect

    Gravel, Roland; Conley, Jason; Kittelson, David

    2008-09-30

    The overall objective of this project was to develop exhaust gas recirculation (EGR) control strategies using fast-response Particulate Matter (PM) sensors and NOx sensors to improve the quality of particulate and gaseous emissions from diesel engines. This project initially comprised three phases: (1) Phase IA - sensor requirements to meet PM sensor specifications, NOx sensor assessment, and initial model development for EGR control; (2) Phase IB - continue development on PM and NOx sensors, integrate the sensor signals into the control simulations, and finalize model development for control strategies; and (3) Phase II - validation testing of the control strategies. Only Phase 1A was funded by DOE and executed by Honeywell. The major objectives of Phase 1A of the project included: (1) Sensor validation and operation of fast-response PM and NOx sensors; (2) Control system modeling of low-pressure EGR controls, development of control strategies, and initial evaluation of these models and strategies for EGR control in diesel engines; (3) Sensor testing to understand applicability of fast-response PM sensors in determining loading rates of the particle trap; and (4) Model validation and sensor testing under steady-state and transient operational conditions of actual engines. In particular, specific objectives included demonstration of: (1) A PM sensor response time constant (T10 - T90) of better than 100 milliseconds (msec); (2) The ability to detect PM at concentrations from 0.2 to 2 Bosch smoke number (BSN) or equivalent; (3) PM sensor accuracy to within 20% BSN over the entire range of operation; and (4) PM sensor repeatability to within 10% over the PM entire sensor range equivalent to a BSN of 0.2 to 2.

  3. Effect of fasting on the metabolic response of liver to experimental burn injury.

    PubMed

    Orman, Mehmet A; Ierapetritou, Marianthi G; Androulakis, Ioannis P; Berthiaume, Francois

    2013-01-01

    Liver metabolism is altered after systemic injuries such as burns and trauma. These changes have been elucidated in rat models of experimental burn injury where the liver was isolated and perfused ex vivo. Because these studies were performed in fasted animals to deplete glycogen stores, thus simplifying quantification of gluconeogenesis, these observations reflect the combined impact of fasting and injury on liver metabolism. Herein we asked whether the metabolic response to experimental burn injury is different in fed vs. fasted animals. Rats were subjected to a cutaneous burn covering 20% of the total body surface area, or to similar procedures without administering the burn, hence a sham-burn. Half of the animals in the burn and sham-burn groups were fasted starting on postburn day 3, and the others allowed to continue ad libitum. On postburn day 4, livers were isolated and perfused for 1 hour in physiological medium supplemented with 10% hematocrit red blood cells. The uptake/release rates of major carbon and nitrogen sources, oxygen, and carbon dioxide were measured during the perfusion and the data fed into a mass balance model to estimate intracellular fluxes. The data show that in fed animals, injury increased glucose output mainly from glycogen breakdown and minimally impacted amino acid metabolism. In fasted animals, injury did not increase glucose output but increased urea production and the uptake of several amino acids, namely glutamine, arginine, glycine, and methionine. Furthermore, sham-burn animals responded to fasting by triggering gluconeogenesis from lactate; however, in burned animals the preferred gluconeogenic substrate was amino acids. Taken together, these results suggest that the fed state prevents the burn-induced increase in hepatic amino acid utilization for gluconeogenesis. The role of glycogen stores and means to increase and/or maintain internal sources of glucose to prevent increased hepatic amino acid utilization warrant further

  4. Predictive models for fast ion profiles relaxation in burning plasmas

    NASA Astrophysics Data System (ADS)

    Gorelenkov, Nikolai; Heidbrink, W. W.; Lestz, J.; Podesta, M.; van Zeeland, M.; White, R. B.

    2014-10-01

    The performance of the burning plasmas is limited by the confinement of superalfvenic fusion products, alpha particles, which are capable to resonate with the Alfvénic eigenmodes (AEs). Two techniques based on linear AE stability theory are developed to evaluate the AE induced fast ion relaxation. The first is the reduced quasilinear technique or critical gradient model (CGM) where marginally unstable (or critical) gradient of fast ion pressure is due to unstable AEs. It allows the reconstruction of fast ion pressure profile and compute their losses. The second technique is called hybrid that is also based on NOVA-K linear stability computations of TAE (or RSAE) mode structures and growth rates. AE amplitudes are computed from the nonlinear theory perturbatively and used in numerical runs. With the help of the guiding center code ORBIT the hybrid model predicts the relaxation of the fast particle profiles. We apply these models for NSTX and DIII-D plasmas with the neutral beam injections in order to validate the models. Both methods are relatively fast ways to predict the fast ion profiles in burning plasmas and can be used for plasma modeling prior to building experimental devices such as ITER. Partially supported by US DOE Contract DE-AC02-09CH11466.

  5. Gompertz kinetics model of fast chemical neurotransmission currents.

    PubMed

    Easton, Dexter M

    2005-10-01

    At a chemical synapse, transmitter molecules ejected from presynaptic terminal(s) bind reversibly with postsynaptic receptors and trigger an increase in channel conductance to specific ions. This paper describes a simple but accurate predictive model for the time course of the synaptic conductance transient, based on Gompertz kinetics. In the model, two simple exponential decay terms set the rates of development and decline of transmitter action. The first, r, triggering conductance activation, is surrogate for the decelerated rate of growth of conductance, G. The second, r', responsible for Y, deactivation of the conductance, is surrogate for the decelerated rate of decline of transmitter action. Therefore, the differential equation for the net conductance change, g, triggered by the transmitter is dg/dt=g(r-r'). The solution of that equation yields the product of G(t), representing activation, and Y(t), which defines the proportional decline (deactivation) of the current. The model fits, over their full-time course, published records of macroscopic ionic current associated with fast chemical transmission. The Gompertz model is a convenient and accurate method for routine analysis and comparison of records of synaptic current and putative transmitter time course. A Gompertz fit requiring only three independent rate constants plus initial current appears indistinguishable from a Markov fit using seven rate constants.

  6. The CLYC-6 and CLYC-7 response to γ-rays, fast and thermal neutrons

    NASA Astrophysics Data System (ADS)

    Giaz, A.; Pellegri, L.; Camera, F.; Blasi, N.; Brambilla, S.; Ceruti, S.; Million, B.; Riboldi, S.; Cazzaniga, C.; Gorini, G.; Nocente, M.; Pietropaolo, A.; Pillon, M.; Rebai, M.; Tardocchi, M.

    2016-02-01

    The crystal Cs2LiYCl6:Ce (CLYC) is a very interesting scintillator material because of its good energy resolution and its capability to identify γ-rays and fast/thermal neutrons. The crystal Cs2LiYCl6:Ce contains 6Li and 35Cl isotopes, therefore, it is possible to detect thermal neutrons through the reaction 6Li(n, α)t while 35Cl ions allow to measure fast neutrons through the reactions 35Cl(n, p)35S and 35Cl(n, α)32P. In this work two CLYC 1″×1″ crystals were used: the first crystal, enriched with 6Li at 95% (CLYC-6) is ideal for thermal neutron measurements while the second one, enriched with 7Li at >99% (CLYC-7) is suitable for fast neutron measurements. The response of CLYC scintillators was measured with different PMT models: timing or spectroscopic, with borosilicate glass or quartz window. The energy resolution, the neutron-γ discrimination and the internal activity are discussed. The capability of CLYC scintillators to discriminate γ rays from neutrons was tested with both thermal and fast neutrons. The thermal neutrons were measured with both detectors, using an AmBe source. The measurements of fast neutrons were performed at the Frascati Neutron Generator facility (Italy) where a deuterium beam was accelerated on a deuterium or on a tritium target, providing neutrons of 2.5 MeV or 14.1 MeV, respectively. The different sensitivity to thermal and fast neutrons of a CLYC-6 and of a CLYC-7 was additionally studied.

  7. The Case for Intelligent Propulsion Control for Fast Engine Response

    NASA Technical Reports Server (NTRS)

    Litt, Jonathan S.; Frederick, Dean K.; Guo, Ten-Huei

    2009-01-01

    Damaged aircraft have occasionally had to rely solely on thrust to maneuver as a consequence of losing hydraulic power needed to operate flight control surfaces. The lack of successful landings in these cases inspired research into more effective methods of utilizing propulsion-only control. That research demonstrated that one of the major contributors to the difficulty in landing is the slow response of the engines as compared to using traditional flight control. To address this, research is being conducted into ways of making the engine more responsive under emergency conditions. This can be achieved by relaxing controller limits, adjusting schedules, and/or redesigning the regulators to increase bandwidth. Any of these methods can enable faster response at the potential expense of engine life and increased likelihood of stall. However, an example sensitivity analysis revealed a complex interaction of the limits and the difficulty in predicting the way to achieve the fastest response. The sensitivity analysis was performed on a realistic engine model, and demonstrated that significantly faster engine response can be achieved compared to standard Bill of Material control. However, the example indicates the need for an intelligent approach to controller limit adjustment in order for the potential to be fulfilled.

  8. [Fast spectral modeling based on Voigt peaks].

    PubMed

    Li, Jin-rong; Dai, Lian-kui

    2012-03-01

    Indirect hard modeling (IHM) is a recently introduced method for quantitative spectral analysis, which was applied to the analysis of nonlinear relation between mixture spectrum and component concentration. In addition, IHM is an effectual technology for the analysis of components of mixture with molecular interactions and strongly overlapping bands. Before the establishment of regression model, IHM needs to model the measured spectrum as a sum of Voigt peaks. The precision of the spectral model has immediate impact on the accuracy of the regression model. A spectrum often includes dozens or even hundreds of Voigt peaks, which mean that spectral modeling is a optimization problem with high dimensionality in fact. So, large operation overhead is needed and the solution would not be numerically unique due to the ill-condition of the optimization problem. An improved spectral modeling method is presented in the present paper, which reduces the dimensionality of optimization problem by determining the overlapped peaks in spectrum. Experimental results show that the spectral modeling based on the new method is more accurate and needs much shorter running time than conventional method. PMID:22582612

  9. Contrasting Responses to Harvesting and Environmental Drivers of Fast and Slow Life History Species.

    PubMed

    Quetglas, Antoni; Rueda, Lucía; Alvarez-Berastegui, Diego; Guijarro, Beatriz; Massutí, Enric

    2016-01-01

    According to their main life history traits, organisms can be arranged in a continuum from fast (species with small body size, short lifespan and high fecundity) to slow (species with opposite characteristics). Life history determines the responses of organisms to natural and anthropogenic factors, as slow species are expected to be more sensitive than fast species to perturbations. Owing to their contrasting traits, cephalopods and elasmobranchs are typical examples of fast and slow strategies, respectively. We investigated the responses of these two contrasting strategies to fishing exploitation and environmental conditions (temperature, productivity and depth) using generalized additive models. Our results confirmed the foreseen contrasting responses of cephalopods and elasmobranchs to natural (environment) and anthropogenic (harvesting) influences. Even though a priori foreseen, we did expect neither the clear-cut differential responses between groups nor the homogeneous sensitivity to the same factors within the two taxonomic groups. Apart from depth, which affected both groups equally, cephalopods and elasmobranchs were exclusively affected by environmental conditions and fishing exploitation, respectively. Owing to its short, annual cycle, cephalopods do not have overlapping generations and consequently lack the buffering effects conferred by different age classes observed in multi-aged species such as elasmobranchs. We suggest that cephalopods are sensitive to short-term perturbations, such as seasonal environmental changes, because they lack this buffering effect but they are in turn not influenced by continuous, long-term moderate disturbances such as fishing because of its high population growth and turnover. The contrary would apply to elasmobranchs, whose multi-aged population structure would buffer the seasonal environmental effects, but they would display strong responses to uninterrupted harvesting due to its low population resilience. Besides

  10. Contrasting Responses to Harvesting and Environmental Drivers of Fast and Slow Life History Species

    PubMed Central

    Quetglas, Antoni; Rueda, Lucía; Alvarez-Berastegui, Diego; Guijarro, Beatriz; Massutí, Enric

    2016-01-01

    According to their main life history traits, organisms can be arranged in a continuum from fast (species with small body size, short lifespan and high fecundity) to slow (species with opposite characteristics). Life history determines the responses of organisms to natural and anthropogenic factors, as slow species are expected to be more sensitive than fast species to perturbations. Owing to their contrasting traits, cephalopods and elasmobranchs are typical examples of fast and slow strategies, respectively. We investigated the responses of these two contrasting strategies to fishing exploitation and environmental conditions (temperature, productivity and depth) using generalized additive models. Our results confirmed the foreseen contrasting responses of cephalopods and elasmobranchs to natural (environment) and anthropogenic (harvesting) influences. Even though a priori foreseen, we did expect neither the clear-cut differential responses between groups nor the homogeneous sensitivity to the same factors within the two taxonomic groups. Apart from depth, which affected both groups equally, cephalopods and elasmobranchs were exclusively affected by environmental conditions and fishing exploitation, respectively. Owing to its short, annual cycle, cephalopods do not have overlapping generations and consequently lack the buffering effects conferred by different age classes observed in multi-aged species such as elasmobranchs. We suggest that cephalopods are sensitive to short-term perturbations, such as seasonal environmental changes, because they lack this buffering effect but they are in turn not influenced by continuous, long-term moderate disturbances such as fishing because of its high population growth and turnover. The contrary would apply to elasmobranchs, whose multi-aged population structure would buffer the seasonal environmental effects, but they would display strong responses to uninterrupted harvesting due to its low population resilience. Besides

  11. Contrasting Responses to Harvesting and Environmental Drivers of Fast and Slow Life History Species.

    PubMed

    Quetglas, Antoni; Rueda, Lucía; Alvarez-Berastegui, Diego; Guijarro, Beatriz; Massutí, Enric

    2016-01-01

    According to their main life history traits, organisms can be arranged in a continuum from fast (species with small body size, short lifespan and high fecundity) to slow (species with opposite characteristics). Life history determines the responses of organisms to natural and anthropogenic factors, as slow species are expected to be more sensitive than fast species to perturbations. Owing to their contrasting traits, cephalopods and elasmobranchs are typical examples of fast and slow strategies, respectively. We investigated the responses of these two contrasting strategies to fishing exploitation and environmental conditions (temperature, productivity and depth) using generalized additive models. Our results confirmed the foreseen contrasting responses of cephalopods and elasmobranchs to natural (environment) and anthropogenic (harvesting) influences. Even though a priori foreseen, we did expect neither the clear-cut differential responses between groups nor the homogeneous sensitivity to the same factors within the two taxonomic groups. Apart from depth, which affected both groups equally, cephalopods and elasmobranchs were exclusively affected by environmental conditions and fishing exploitation, respectively. Owing to its short, annual cycle, cephalopods do not have overlapping generations and consequently lack the buffering effects conferred by different age classes observed in multi-aged species such as elasmobranchs. We suggest that cephalopods are sensitive to short-term perturbations, such as seasonal environmental changes, because they lack this buffering effect but they are in turn not influenced by continuous, long-term moderate disturbances such as fishing because of its high population growth and turnover. The contrary would apply to elasmobranchs, whose multi-aged population structure would buffer the seasonal environmental effects, but they would display strong responses to uninterrupted harvesting due to its low population resilience. Besides

  12. Surface Water Response Modeling

    EPA Science Inventory

    During response to spills, or for facility planning, the vulnerability of downstream water resources is a major concern. How long and at what concentration do spilled contaminants reach downstream receptors? Models have the potential to answer these questions, but only if they ...

  13. Adaptive response modelling

    NASA Astrophysics Data System (ADS)

    Campa, Alessandro; Esposito, Giuseppe; Belli, Mauro

    Cellular response to radiation is often modified by a previous delivery of a small "priming" dose: a smaller amount of damage, defined by the end point being investigated, is observed, and for this reason the effect is called adaptive response. An improved understanding of this effect is essential (as much as for the case of the bystander effect) for a reliable radiation risk assessment when low dose irradiations are involved. Experiments on adaptive response have shown that there are a number of factors that strongly influence the occurrence (and the level) of the adaptation. In particular, priming doses and dose rates have to fall in defined ranges; the same is true for the time interval between the delivery of the small priming dose and the irradiation with the main, larger, dose (called in this case challenging dose). Different hypotheses can be formulated on the main mechanism(s) determining the adaptive response: an increased efficiency of DNA repair, an increased level of antioxidant enzymes, an alteration of cell cycle progression, a chromatin conformation change. An experimental clearcut evidence going definitely in the direction of one of these explanations is not yet available. Modelling can be done at different levels. Simple models, relating the amount of damage, through elementary differential equations, to the dose and dose rate experienced by the cell, are relatively easy to handle, and they can be modified to account for the priming irradiation. However, this can hardly be of decisive help in the explanation of the mechanisms, since each parameter of these models often incorporates in an effective way several cellular processes related to the response to radiation. In this presentation we show our attempts to describe adaptive response with models that explicitly contain, as a dynamical variable, the inducible adaptive agent. At a price of a more difficult treatment, this approach is probably more prone to give support to the experimental studies

  14. Metabolic response to a glucagon challenge varies with adiposity and life-history stage in fasting northern elephant seals.

    PubMed

    Crocker, Daniel E; Fowler, Melinda A; Champagne, Cory D; Vanderlugt, Anna L; Houser, Dorian S

    2014-01-01

    Metabolic adaptations for extended fasting in wildlife prioritize beta-oxidation of lipids and reduced glucose utilization to support energy metabolism. The pancreatic hormone glucagon plays key roles in regulating glycemia and lipid metabolism during fasting in model species but its function in wildlife species adapted for extended fasting is not well understood. Northern elephant seals (NES) undergo natural fasts of 1-3months while under constraints of high nutrient demands including lactation and development. We performed a glucagon challenge on lactating, molting and developing NES, early and late in their natural fasts, to examine the impact of this important regulatory hormone on metabolism. Glucagon caused increases in plasma glucose, insulin, fatty acids, ketones and urea, but the magnitude of these effects varied widely with adiposity and life-history stage. The strong impact of adiposity on glucose and insulin responses suggest a potential role for adipose derived factors in regulating hepatic metabolism and pancreatic sensitivity. Elevations in plasma glucose in response to glucagon were strongly associated with increases in protein catabolism, suggesting negative impacts of elevated glucagon on protein sparing. Glucagon promoted rapid ketone accumulation suggesting that low ketoacid levels in NES reflect low rates of production. These results demonstrate strong metabolic impacts of glucagon and support the idea that glucagon levels are downregulated in the context of metabolic adaptation to extended fasting. These results suggest that the regulation of carbohydrate and lipid metabolism in NES changes with adiposity, fasting duration and under various constraints of nutrient demands.

  15. Metabolic response to a glucagon challenge varies with adiposity and life-history stage in fasting northern elephant seals.

    PubMed

    Crocker, Daniel E; Fowler, Melinda A; Champagne, Cory D; Vanderlugt, Anna L; Houser, Dorian S

    2014-01-01

    Metabolic adaptations for extended fasting in wildlife prioritize beta-oxidation of lipids and reduced glucose utilization to support energy metabolism. The pancreatic hormone glucagon plays key roles in regulating glycemia and lipid metabolism during fasting in model species but its function in wildlife species adapted for extended fasting is not well understood. Northern elephant seals (NES) undergo natural fasts of 1-3months while under constraints of high nutrient demands including lactation and development. We performed a glucagon challenge on lactating, molting and developing NES, early and late in their natural fasts, to examine the impact of this important regulatory hormone on metabolism. Glucagon caused increases in plasma glucose, insulin, fatty acids, ketones and urea, but the magnitude of these effects varied widely with adiposity and life-history stage. The strong impact of adiposity on glucose and insulin responses suggest a potential role for adipose derived factors in regulating hepatic metabolism and pancreatic sensitivity. Elevations in plasma glucose in response to glucagon were strongly associated with increases in protein catabolism, suggesting negative impacts of elevated glucagon on protein sparing. Glucagon promoted rapid ketone accumulation suggesting that low ketoacid levels in NES reflect low rates of production. These results demonstrate strong metabolic impacts of glucagon and support the idea that glucagon levels are downregulated in the context of metabolic adaptation to extended fasting. These results suggest that the regulation of carbohydrate and lipid metabolism in NES changes with adiposity, fasting duration and under various constraints of nutrient demands. PMID:24239794

  16. Reduced Fast Ion Transport Model For The Tokamak Transport Code TRANSP

    SciTech Connect

    Podesta,, Mario; Gorelenkova, Marina; White, Roscoe

    2014-02-28

    Fast ion transport models presently implemented in the tokamak transport code TRANSP [R. J. Hawryluk, in Physics of Plasmas Close to Thermonuclear Conditions, CEC Brussels, 1 , 19 (1980)] are not capturing important aspects of the physics associated with resonant transport caused by instabilities such as Toroidal Alfv en Eigenmodes (TAEs). This work describes the implementation of a fast ion transport model consistent with the basic mechanisms of resonant mode-particle interaction. The model is formulated in terms of a probability distribution function for the particle's steps in phase space, which is consistent with the MonteCarlo approach used in TRANSP. The proposed model is based on the analysis of fast ion response to TAE modes through the ORBIT code [R. B. White et al., Phys. Fluids 27 , 2455 (1984)], but it can be generalized to higher frequency modes (e.g. Compressional and Global Alfv en Eigenmodes) and to other numerical codes or theories.

  17. NASA AVOSS Fast-Time Wake Prediction Models: User's Guide

    NASA Technical Reports Server (NTRS)

    Ahmad, Nash'at N.; VanValkenburg, Randal L.; Pruis, Matthew

    2014-01-01

    The National Aeronautics and Space Administration (NASA) is developing and testing fast-time wake transport and decay models to safely enhance the capacity of the National Airspace System (NAS). The fast-time wake models are empirical algorithms used for real-time predictions of wake transport and decay based on aircraft parameters and ambient weather conditions. The aircraft dependent parameters include the initial vortex descent velocity and the vortex pair separation distance. The atmospheric initial conditions include vertical profiles of temperature or potential temperature, eddy dissipation rate, and crosswind. The current distribution includes the latest versions of the APA (3.4) and the TDP (2.1) models. This User's Guide provides detailed information on the model inputs, file formats, and the model output. An example of a model run and a brief description of the Memphis 1995 Wake Vortex Dataset is also provided.

  18. A Fast Incremental Gaussian Mixture Model

    PubMed Central

    Pinto, Rafael Coimbra; Engel, Paulo Martins

    2015-01-01

    This work builds upon previous efforts in online incremental learning, namely the Incremental Gaussian Mixture Network (IGMN). The IGMN is capable of learning from data streams in a single-pass by improving its model after analyzing each data point and discarding it thereafter. Nevertheless, it suffers from the scalability point-of-view, due to its asymptotic time complexity of O(NKD3) for N data points, K Gaussian components and D dimensions, rendering it inadequate for high-dimensional data. In this work, we manage to reduce this complexity to O(NKD2) by deriving formulas for working directly with precision matrices instead of covariance matrices. The final result is a much faster and scalable algorithm which can be applied to high dimensional tasks. This is confirmed by applying the modified algorithm to high-dimensional classification datasets. PMID:26444880

  19. Fast Algorithms for Model-Based Diagnosis

    NASA Technical Reports Server (NTRS)

    Fijany, Amir; Barrett, Anthony; Vatan, Farrokh; Mackey, Ryan

    2005-01-01

    Two improved new methods for automated diagnosis of complex engineering systems involve the use of novel algorithms that are more efficient than prior algorithms used for the same purpose. Both the recently developed algorithms and the prior algorithms in question are instances of model-based diagnosis, which is based on exploring the logical inconsistency between an observation and a description of a system to be diagnosed. As engineering systems grow more complex and increasingly autonomous in their functions, the need for automated diagnosis increases concomitantly. In model-based diagnosis, the function of each component and the interconnections among all the components of the system to be diagnosed (for example, see figure) are represented as a logical system, called the system description (SD). Hence, the expected behavior of the system is the set of logical consequences of the SD. Faulty components lead to inconsistency between the observed behaviors of the system and the SD. The task of finding the faulty components (diagnosis) reduces to finding the components, the abnormalities of which could explain all the inconsistencies. Of course, the meaningful solution should be a minimal set of faulty components (called a minimal diagnosis), because the trivial solution, in which all components are assumed to be faulty, always explains all inconsistencies. Although the prior algorithms in question implement powerful methods of diagnosis, they are not practical because they essentially require exhaustive searches among all possible combinations of faulty components and therefore entail the amounts of computation that grow exponentially with the number of components of the system.

  20. BISON and MARMOT Development for Modeling Fast Reactor Fuel Performance

    SciTech Connect

    Gamble, Kyle Allan Lawrence; Williamson, Richard L.; Schwen, Daniel; Zhang, Yongfeng; Novascone, Stephen Rhead; Medvedev, Pavel G.

    2015-09-01

    BISON and MARMOT are two codes under development at the Idaho National Laboratory for engineering scale and lower length scale fuel performance modeling. It is desired to add capabilities for fast reactor applications to these codes. The fast reactor fuel types under consideration are metal (U-Pu-Zr) and oxide (MOX). The cladding types of interest include 316SS, D9, and HT9. The purpose of this report is to outline the proposed plans for code development and provide an overview of the models added to the BISON and MARMOT codes for fast reactor fuel behavior. A brief overview of preliminary discussions on the formation of a bilateral agreement between the Idaho National Laboratory and the National Nuclear Laboratory in the United Kingdom is presented.

  1. Fast Analytical Methods for Macroscopic Electrostatic Models in Biomolecular Simulations*

    PubMed Central

    Xu, Zhenli; Cai, Wei

    2013-01-01

    We review recent developments of fast analytical methods for macroscopic electrostatic calculations in biological applications, including the Poisson–Boltzmann (PB) and the generalized Born models for electrostatic solvation energy. The focus is on analytical approaches for hybrid solvation models, especially the image charge method for a spherical cavity, and also the generalized Born theory as an approximation to the PB model. This review places much emphasis on the mathematical details behind these methods. PMID:23745011

  2. Nanorod-Based Fast-Response Pressure-Sensitive Paints

    NASA Technical Reports Server (NTRS)

    Bencic, Timothy; VanderWal, Randall

    2007-01-01

    A proposed program of research and development would be devoted to exploitation of nanomaterials in pressuresensitive paints (PSPs), which are used on wind-tunnel models for mapping surface pressures associated with flow fields. Heretofore, some success has been achieved in measuring steady-state pressures by use of PSPs, but success in measuring temporally varying pressures has been elusive because of the inherent slowness of the optical responses of these materials. A PSP contains a dye that luminesces in a suitable wavelength range in response to photoexcitation in a shorter wavelength range. The luminescence is quenched by oxygen at a rate proportional to the partial pressure of oxygen and thus proportional to the pressure of air. As a result, the intensity of luminescence varies inversely with the pressure of air. The major problem in developing a PSP that could be easily applied to a wind-tunnel model and could be useful for measuring rapidly varying pressure is to provide very high gas diffusivity for rapid, easy transport of oxygen to and from active dye molecules. Most PSPs include polymer-base binders, which limit the penetration of oxygen to dye molecules, thereby reducing responses to pressure fluctuations. The proposed incorporation of nanomaterials (somewhat more specifically, nanorods) would result in paints having nanostructured surfaces that, relative to conventional PSP surfaces, would afford easier and more nearly complete access of oxygen molecules to dye molecules. One measure of greater access is effective surface area: For a typical PSP as proposed applied to a given solid surface, the nanometer-scale structural features would result in an exposed surface area more than 100 times that of a conventional PSP, and the mass of proposed PSP needed to cover the surface would be less than tenth of the mass of the conventional PSP. One aspect of the proposed development would be to synthesize nanorods of Si/SiO2, in both tangle-mat and regular- array

  3. Fast loop modeling for protein structures

    NASA Astrophysics Data System (ADS)

    Zhang, Jiong; Nguyen, Son; Shang, Yi; Xu, Dong; Kosztin, Ioan

    2015-03-01

    X-ray crystallography is the main method for determining 3D protein structures. In many cases, however, flexible loop regions of proteins cannot be resolved by this approach. This leads to incomplete structures in the protein data bank, preventing further computational study and analysis of these proteins. For instance, all-atom molecular dynamics (MD) simulation studies of structure-function relationship require complete protein structures. To address this shortcoming, we have developed and implemented an efficient computational method for building missing protein loops. The method is database driven and uses deep learning and multi-dimensional scaling algorithms. We have implemented the method as a simple stand-alone program, which can also be used as a plugin in existing molecular modeling software, e.g., VMD. The quality and stability of the generated structures are assessed and tested via energy scoring functions and by equilibrium MD simulations. The proposed method can also be used in template-based protein structure prediction. Work supported by the National Institutes of Health [R01 GM100701]. Computer time was provided by the University of Missouri Bioinformatics Consortium.

  4. The challenge in making models of fast CMEs

    SciTech Connect

    Mikic, Zoran; Toeroek, Tibor; Titov, Viacheslav; Linker, Jon A.; Lionello, Roberto; Downs, Cooper; Riley, Pete

    2013-06-13

    It has been a challenge to explain theoretically how fast CMEs (exceeding {approx} 1,000km/s) occur. Our numerical models suggest that it is not easy to release enough magnetic energy impulsively from an active region. We have been studying CME models that are constrained by observed magnetic fields, with realistic coronal plasma density and temperature profiles, as derived from thermodynamic models of the corona. We find that to get fast CMEs, the important parameters are the magnetic energy density, the magnetic field drop-off index, and the Alfven speed profile in active regions. We describe how we energize active regions, and how we subsequently initiate CMEs via flux cancellation. We contrast CMEs from idealized zero-beta models with more sophisticated models based on thermodynamic solutions.

  5. Thermo-responsive Hercosett/Poly(N-isopropylacrylamide) films: a new, fast, optically responsive coating.

    PubMed

    Wang, Jing; Sutti, Alessandra; Wang, Xungai; Lin, Tong

    2012-03-01

    Poly(N-isopropylacrylamide) (PNIPAM) is a common thermo-responsive, water-soluble polymer, while Hercosett is a cationic resin commonly employed in the paper industry. In this paper, Hercosett™ and poly(N-isopropylacrylamide) (PNIPAM) nanoparticles were used to prepare composite films that show thermo-responsive behavior and swelling-shrinking properties in water. First, size-controlled PNIPAM hydrogel nanoparticles were synthesized. These were then embedded within a matrix of the cationic resin Kymene 577H by film casting. The distribution of nanoparticles in the resin film was investigated. The thermo-responsive properties of the as-synthesized PNIPAM hydrogel nanoparticles and of the composite films were characterized together with the repeatability of the swelling-shrinking cycles. The presence of nanoparticles endowed the film with highly enhanced water retention (in comparison with resin-only films) and, most importantly, thermo-responsiveness. A very fast optical and morphological response was in fact observed. Due to the dual (optical and morphological) response, this new system is suitable for applications in optical or morphological actuation and gating. PMID:22236607

  6. Finite Post Synaptic Potentials Cause a Fast Neuronal Response

    PubMed Central

    Helias, Moritz; Deger, Moritz; Rotter, Stefan; Diesmann, Markus

    2011-01-01

    A generic property of the communication between neurons is the exchange of pulses at discrete time points, the action potentials. However, the prevalent theory of spiking neuronal networks of integrate-and-fire model neurons relies on two assumptions: the superposition of many afferent synaptic impulses is approximated by Gaussian white noise, equivalent to a vanishing magnitude of the synaptic impulses, and the transfer of time varying signals by neurons is assessable by linearization. Going beyond both approximations, we find that in the presence of synaptic impulses the response to transient inputs differs qualitatively from previous predictions. It is instantaneous rather than exhibiting low-pass characteristics, depends non-linearly on the amplitude of the impulse, is asymmetric for excitation and inhibition and is promoted by a characteristic level of synaptic background noise. These findings resolve contradictions between the earlier theory and experimental observations. Here we review the recent theoretical progress that enabled these insights. We explain why the membrane potential near threshold is sensitive to properties of the afferent noise and show how this shapes the neural response. A further extension of the theory to time evolution in discrete steps quantifies simulation artifacts and yields improved methods to cross check results. PMID:21427776

  7. Effects of corticosterone treatment on responses to fasting in Japanese quail.

    PubMed

    Wall, Julian P; Cockrem, John F

    2009-10-01

    Plasma concentrations of corticosterone, a glucocorticoid hormone, have been reported to increase during fasting in some species of birds. Although Japanese quail are widely used in laboratory studies, corticosterone responses to fasting have not been described for this species. We therefore investigated the effects of 24h of fasting on plasma corticosterone concentrations in quail. Previous work has shown that the corticosterone response to handling in quail may be affected by treatment with corticosterone, so we also measured corticosterone responses to 24h of fasting in quail treated with corticosterone in their drinking water, and determined the effects of corticosterone on food intake immediately after a fast. Plasma corticosterone concentrations were unaffected by 24h of fasting in controls and in three out of four groups of birds with varying corticosterone intakes. Fasting in birds can be divided into three phases, and our results suggest that quail remained in phase I during the 24h fast. Food intake in the 3h immediately after fasting was higher in four groups of birds with varying corticosterone intakes than in the control group, and was greatest in quail with the highest corticosterone intake. The current results suggest that corticosterone can stimulate food intake in quail following a period of food deprivation. PMID:19539044

  8. Response of surge protection devices to fast rising pulses

    NASA Technical Reports Server (NTRS)

    Mindel, I. N.

    1980-01-01

    Two types of lightning protection modules incorporating leadless (pill type) Zener like devices were evaluated with regard to their ability to suppress EMP induced transients. Two series of tests were performed to evaluate the ability of these modules to react to fast rate of rise ( 1Kv/ns) transients, and the attenuation introduced and the ability to limit damped sinusoid pulses which may be induced due to an EMP resulting from a nuclear detonation.

  9. Fast bias dependent device models for CAD of MMICs

    NASA Astrophysics Data System (ADS)

    Daniel, Tom T.; Tayrani, Reza

    1995-02-01

    Fast and accurate physics-based models for High Electron Mobility Transistors (HEMTs) and Metal-Semiconductor Field-Effect Transistors (MESFETs) suitable for computer-aided design of Monolithic Microwave Integrated Circuits (MMICs) are described. These models are incorporated into Microwave Harmonica(sup trademark) to enable the prediction of device IV characteristics and nonlinear performance, as well as bias dependent equivalent circuit parameters from device geometry and material profile.

  10. Modeling fast and slow earthquakes at various scales.

    PubMed

    Ide, Satoshi

    2014-01-01

    Earthquake sources represent dynamic rupture within rocky materials at depth and often can be modeled as propagating shear slip controlled by friction laws. These laws provide boundary conditions on fault planes embedded in elastic media. Recent developments in observation networks, laboratory experiments, and methods of data analysis have expanded our knowledge of the physics of earthquakes. Newly discovered slow earthquakes are qualitatively different phenomena from ordinary fast earthquakes and provide independent information on slow deformation at depth. Many numerical simulations have been carried out to model both fast and slow earthquakes, but problems remain, especially with scaling laws. Some mechanisms are required to explain the power-law nature of earthquake rupture and the lack of characteristic length. Conceptual models that include a hierarchical structure over a wide range of scales would be helpful for characterizing diverse behavior in different seismic regions and for improving probabilistic forecasts of earthquakes.

  11. Modeling fast and slow earthquakes at various scales

    PubMed Central

    IDE, Satoshi

    2014-01-01

    Earthquake sources represent dynamic rupture within rocky materials at depth and often can be modeled as propagating shear slip controlled by friction laws. These laws provide boundary conditions on fault planes embedded in elastic media. Recent developments in observation networks, laboratory experiments, and methods of data analysis have expanded our knowledge of the physics of earthquakes. Newly discovered slow earthquakes are qualitatively different phenomena from ordinary fast earthquakes and provide independent information on slow deformation at depth. Many numerical simulations have been carried out to model both fast and slow earthquakes, but problems remain, especially with scaling laws. Some mechanisms are required to explain the power-law nature of earthquake rupture and the lack of characteristic length. Conceptual models that include a hierarchical structure over a wide range of scales would be helpful for characterizing diverse behavior in different seismic regions and for improving probabilistic forecasts of earthquakes. PMID:25311138

  12. Assessing cognitive processes with diffusion model analyses: a tutorial based on fast-dm-30

    PubMed Central

    Voss, Andreas; Voss, Jochen; Lerche, Veronika

    2015-01-01

    Diffusion models can be used to infer cognitive processes involved in fast binary decision tasks. The model assumes that information is accumulated continuously until one of two thresholds is hit. In the analysis, response time distributions from numerous trials of the decision task are used to estimate a set of parameters mapping distinct cognitive processes. In recent years, diffusion model analyses have become more and more popular in different fields of psychology. This increased popularity is based on the recent development of several software solutions for the parameter estimation. Although these programs make the application of the model relatively easy, there is a shortage of knowledge about different steps of a state-of-the-art diffusion model study. In this paper, we give a concise tutorial on diffusion modeling, and we present fast-dm-30, a thoroughly revised and extended version of the fast-dm software (Voss and Voss, 2007) for diffusion model data analysis. The most important improvement of the fast-dm version is the possibility to choose between different optimization criteria (i.e., Maximum Likelihood, Chi-Square, and Kolmogorov-Smirnov), which differ in applicability for different data sets. PMID:25870575

  13. The response of the hypothalamic-pituitary-gonadal axis to fasting is modulated by leptin.

    PubMed

    Steiner, J; LaPaglia, N; Kirsteins, L; Emanuele, M; Emanuele, N

    2003-05-01

    Reproductive function is intimately related to caloric consumption. During fasting states, the hormones regulating reproduction, those of the hypothalamic-pituitary-gonadal axis, in particular, are severely altered. With the exciting observations that the obese (ob) gene product leptin, may also modulate neuroendocrine functions, we examined leptin's ability to prevent the consequences of fasting on reproductive hormones. Two groups of male rats, aged 65 days old, were either fasted and saline-injected or fasted and leptin-treated for approximately three days. Another group was given free access to rat chow. Leptin was able to prevent the fasting-induced fall of serum testosterone. Similar to testosterones dependence on leptin, leptin concentrations were somewhat dependent on testosterone. Castration accelerated the normal, age-related increase in serum leptin. Leptin also prevented the fasting-induced fall in luteinizing hormone (LH). The increase of beta-LH mRNA seen in the fasting state was prevented by leptin. There were no differences noted in luteinizing hormone releasing hormone (LHRH) mRNA among any of the groups. While neither fasting nor fasting plus leptin caused changes in serum prolactin, the increase in prolactin mRNA seen in fasted animals was prevented by leptin treatment. These data support the hypothesis that leptin plays a specific role in mediating the response of reproductive hormones to the nutritional status of the organism.

  14. Seismic responses of a pool-type fast reactor with different core support designs

    SciTech Connect

    Wu, Ting-shu; Seidensticker, R.W. )

    1989-01-01

    In designing the core support system for a pool-type fast reactor, there are many issues which must be considered in order to achieve an optimum and balanced design. These issues include safety, reliability, as well as costs. Several design options are possible to support the reactor core. Different core support options yield different frequency ranges and responses. Seismic responses of a large pool-type fast reactor incorporated with different core support designs have been investigated. 4 refs., 3 figs.

  15. Physiological responses to food deprivation in the house sparrow, a species not adapted to prolonged fasting.

    PubMed

    Khalilieh, Anton; McCue, Marshall D; Pinshow, Berry

    2012-09-01

    Many wild birds fast during reproduction, molting, migration, or because of limited food availability. Species that are adapted to fasting sequentially oxidize endogenous fuels in three discrete phases. We hypothesized that species not adapted to long fasts have truncated, but otherwise similar, phases of fasting, sequential changes in fuel oxidization, and similar changes in blood metabolites to fasting-adapted species. We tested salient predictions in house sparrows (Passer domesticus biblicus), a subspecies that is unable to tolerate more than ~32 h of fasting. Our main hypothesis was that fasting sparrows sequentially oxidize substrates in the order carbohydrates, lipids, and protein. We dosed 24 house sparrows with [(13)C]glucose, palmitic acid, or glycine and measured (13)CO(2) in their breath while they fasted for 24 h. To ascertain whether blood metabolite levels reflect fasting-induced changes in metabolic fuels, we also measured glucose, triacylglycerides, and β-hydroxybutyrate in the birds' blood. The results of both breath (13)CO(2) and plasma metabolite analyses did not support our hypothesis; i.e., that sparrows have the same metabolic responses characteristic of fasting-adapted species, but on a shorter time scale. Contrary to our main prediction, we found that recently assimilated (13)C-tracers were oxidized continuously in different patterns with no definite peaks corresponding to the three phases of fasting and also that changes in plasma metabolite levels accurately tracked the changes found by breath analysis. Notably, the rate of recently assimilated [(13)C]glycine oxidization was significantly higher (P < 0.001) than that of the other metabolic tracers at all postdosing intervals. We conclude that the inability of house sparrows to fast for longer than 32 h is likely related to their inability to accrue large lipid stores, separately oxidize different fuels, and/or spare protein during fasting.

  16. A Fast Technology Infusion Model for Aerospace Organizations

    NASA Technical Reports Server (NTRS)

    Shapiro, Andrew A.; Schone, Harald; Brinza, David E.; Garrett, Henry B.; Feather, Martin S.

    2006-01-01

    A multi-year Fast Technology Infusion initiative proposes a model for aerospace organizations to improve the cost-effectiveness by which they mature new, in-house developed software and hardware technologies for space mission use. The first year task under the umbrella of this initiative will provide the framework to demonstrate and document the fast infusion process. The viability of this approach will be demonstrated on two technologies developed in prior years with internal Jet Propulsion Laboratory (JPL) funding. One hardware technology and one software technology were selected for maturation within one calendar year or less. The overall objective is to achieve cost and time savings in the qualification of technologies. At the end of the recommended three-year effort, we will have demonstrated for six or more in-house developed technologies a clear path to insertion using a documented process that permits adaptation to a broad range of hardware and software projects.

  17. Electronic and structural response of materials to fast intense laser pulses, including light-induced superconductivity

    NASA Astrophysics Data System (ADS)

    Allen, Roland E.

    2016-06-01

    This is a very brief discussion of some experimental and theoretical studies of materials responding to fast intense laser pulses, with emphasis on those cases where the electronic response and structural response are both potentially important (and ordinarily coupled). Examples are nonthermal insulator-to-metal transitions and light-induced superconductivity in cuprates, fullerenes, and an organic Mott insulator.

  18. Effect of fasting versus feeding on the bone metabolic response to running.

    PubMed

    Scott, Jonathan P R; Sale, Craig; Greeves, Julie P; Casey, Anna; Dutton, John; Fraser, William D

    2012-12-01

    Individuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-active males aged 28 ± 4y (mean ±SD) completed two, counterbalanced, 8d trials. After 3d on a standardised diet, participants performed 60 min of treadmill running at 65% VO(2max) on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before and during exercise, for 3h after exercise, and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for the c-terminal telopeptide region of collagen type 1 (β-CTX), n-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone alkaline phosphatase (bone ALP), parathyroid hormone (PTH), albumin-adjusted calcium, phosphate, osteoprotegerin (OPG), cortisol, leptin and ghrelin. Only the β-CTX response was significantly affected by feeding. Pre-exercise concentrations decreased more in FED compared with FAST (47% vs 26%, P<0.001) but increased during exercise in both groups and were not significantly different from baseline at 1h post-exercise. At 3h post-exercise, concentrations were decreased (33%, P<0.001) from baseline in FAST and significantly lower (P<0.001) than in FED. P1NP and PTH increased, and OC decreased during exercise. Bone markers were not significantly different from baseline on FU1-FU4. Fasting had only a minor effect on the bone metabolic response to subsequent acute, endurance exercise, reducing the duration of the increase in β-CTX during early recovery, but having no effect on changes in bone formation markers. The reduced duration of the β-CTX response with fasting was not fully explained by changes in PTH, OPG, leptin or ghrelin. PMID:22960044

  19. Polycrystalline CVD diamond detector: Fast response and high sensitivity with large area

    SciTech Connect

    Liu, Linyue Zhang, Xianpeng; Zhong, Yunhong; Ouyang, Xiaoping Zhang, Jianfu

    2014-01-15

    Polycrystalline diamond was successfully used to fabricate a large area (diameter up to 46 mm) radiation detector. It was proven that the developed detector shows a fast pulsed response time and a high sensitivity, therefore its rise time is lower than 5 ns, which is two times faster than that of a Si-PIN detector of the same size. And because of the large sensitive area, this detector shows good dominance in fast pulsed and low density radiation detection.

  20. Fast and Efficient Dynamic WDM Semiconductor Optical Amplifier Model

    NASA Astrophysics Data System (ADS)

    Mathlouthi, Walid; Lemieux, Pascal; Salsi, Massimiliano; Vannucci, Armando; Bononi, Alberto; Rusch, Leslie A.

    2006-11-01

    A novel state-variable model for semiconductor optical amplifiers (SOAs) that is amenable to block diagram implementation of wavelength division multiplexed (WDM) signals and fast execution times is presented. The novel model is called the reservoir model, in analogy with similar block-oriented models for Raman and erbium-doped fiber amplifiers (EDFAs). A procedure is proposed to extract the needed reservoir model parameters from the parameters of a detailed and accurate space-resolved SOA model due to Connelly, which was extended to cope with the time-resolved gain transient analysis. Several variations of the reservoir model are considered with increasing complexity, which allow the accurate inclusion of scattering losses and gain saturation induced by amplified spontaneous emission. It is shown that at comparable accuracy, the reservoir model can be 20 times faster than the Connelly model in single-channel operation; much more significant time savings are expected for WDM operation. The model neglects intraband SOA phenomena and is thus limited to modulation rates per channel not exceeding 10 Gb/s. The SOA reservoir model provides a unique tool with reasonably short computation times for a reliable analysis of gain transients in WDM optical networks with complex topologies.

  1. The effects of fasting on the thermogenic, metabolic and cardiovascular responses to infused adrenaline.

    PubMed

    Webber, J; Taylor, J; Greathead, H; Dawson, J; Buttery, P J; Macdonald, I A

    1995-10-01

    The effects of fasting on the thermogenic, lipolytic and cardiovascular responses to adrenaline were examined in nine normal, young, non-obese subjects. Each subject attended for study after 12, 36 and 72 h fasting. After basal measurements adrenaline was infused at 25 ng/min per kg ideal body weight for 90 min. Fasting increased the thermogenic effect of the adrenaline (mean 14.6 (SE 1.7), 16.6 (SE 1.8), 22.6 (SE 1.6) J/min per kg fat-free mass after 12, 36 and 72 h fasting respectively; P < 0.001, ANOVA). Basal plasma palmitate turnover increased with duration of fasting (1.48 (SE 0.22), 1.95 (SE 0.34) and 2.26 (SE 0.33) mumol/min per kg body weight; P < 0.001, ANOVA), but the response to adrenaline was unaffected by fasting. The percentage values for basal plasma palmitate turnover oxidized were 44 (SE 2; 12 h), 46 (SE 5; 36 h) and 42 (SE 4)% (72 h). In response to adrenaline this percentage fell, suggesting that adrenaline infusion may favour intra-tissue lipid oxidation.

  2. PYTRANSIT: fast and easy exoplanet transit modelling in PYTHON

    NASA Astrophysics Data System (ADS)

    Parviainen, Hannu

    2015-07-01

    We present a fast and user friendly exoplanet transit light-curve modelling package PYTRANSIT, implementing optimized versions of the Giménez and Mandel & Agol transit models. The package offers an object-oriented PYTHON interface to access the two models implemented natively in FORTRAN with OpenMP parallelization. A partial OpenCL version of the quadratic Mandel-Agol model is also included for GPU-accelerated computations. The aim of PYTRANSIT is to facilitate the analysis of photometric time series of exoplanet transits consisting of hundreds of thousands of data points, and of multipassband transit light curves from spectrophotometric observations, as a part of a researcher's programming toolkit for building complex, problem-specific analyses.

  3. Randomized Item Response Theory Models

    ERIC Educational Resources Information Center

    Fox, Jean-Paul

    2005-01-01

    The randomized response (RR) technique is often used to obtain answers on sensitive questions. A new method is developed to measure latent variables using the RR technique because direct questioning leads to biased results. Within the RR technique is the probability of the true response modeled by an item response theory (IRT) model. The RR…

  4. Modeling Fast Ion Transport in TAE Avalanches in NSTX

    SciTech Connect

    Fredrickson, E D; Bell, R E; Darrow, D; Gorelenkov, N N; Kramer, G; Kubota, S; Levinton, F M; Liu, D; Medley, S S; Podesta, M; Tritz, K

    2009-08-17

    Experiments on the National Spherical Torus Experiment [M. Ono, et al., Nucl. Fusion 40 (2000) 557 ] have found strong bursts of Toroidal Alfven Eigenmode (TAE) activity correlated with abrupt drops in the neutron rate. A fairly complete data set offers the opportunity to benchmark the NOVA [C. Z. Cheng, Phys. Reports 211, 1-51 (1992)] and ORBIT [R. B. White and M. S. Chance, Phys. Fluids 27, 2455 (1984)] codes in the low aspect ratio tokamak (ST) geometry. The internal structure of TAE were modeled with NOVA and good agreement is found with measurements made with an array of five fixed-frequency reflectometers. The fast-ion transport resulting from these bursts of multiple TAE were then modeled with the ORBIT code. The simulations are reasonably consistent with the observed drop in neutron rate. While these results represent our best attempts to find agreement, we believe that further refinements in both the simulation of the TAE structure and in the modeling of the fast ion transport are needed. Benchmarking stability codes against present experiments is an important step in developing the predictive capability needed to plan future experiments.

  5. Unified Dark Matter scalar field models with fast transition

    SciTech Connect

    Bertacca, Daniele; Bruni, Marco; Piattella, Oliver F.; Pietrobon, Davide E-mail: marco.bruni@port.ac.uk E-mail: davide.pietrobon@jpl.nasa.gov

    2011-02-01

    We investigate the general properties of Unified Dark Matter (UDM) scalar field models with Lagrangians with a non-canonical kinetic term, looking specifically for models that can produce a fast transition between an early Einstein-de Sitter CDM-like era and a later Dark Energy like phase, similarly to the barotropic fluid UDM models in JCAP01(2010)014. However, while the background evolution can be very similar in the two cases, the perturbations are naturally adiabatic in fluid models, while in the scalar field case they are necessarily non-adiabatic. The new approach to building UDM Lagrangians proposed here allows to escape the common problem of the fine-tuning of the parameters which plague many UDM models. We analyse the properties of perturbations in our model, focusing on the the evolution of the effective speed of sound and that of the Jeans length. With this insight, we can set theoretical constraints on the parameters of the model, predicting sufficient conditions for the model to be viable. An interesting feature of our models is that what can be interpreted as w{sub DE} can be < −1 without violating the null energy conditions.

  6. Generalizability in Item Response Modeling

    ERIC Educational Resources Information Center

    Briggs, Derek C.; Wilson, Mark

    2007-01-01

    An approach called generalizability in item response modeling (GIRM) is introduced in this article. The GIRM approach essentially incorporates the sampling model of generalizability theory (GT) into the scaling model of item response theory (IRT) by making distributional assumptions about the relevant measurement facets. By specifying a random…

  7. The time-course of single-word reading: evidence from fast behavioral and brain responses.

    PubMed

    Hauk, O; Coutout, C; Holden, A; Chen, Y

    2012-04-01

    We usually feel that we understand a familiar word "immediately". However, even basic aspects of the time-line of word recognition are still controversial. Different domains of research have still not converged on a coherent account. An integration of multiple sources of information would lead to more strongly constrained theoretical models, and help finding optimal measures when monitoring specific aspects of word recognition impairments in patient groups. In our multimodal approach--combining fast behavioral measures, ERPs and EEG/MEG source estimation--we provide converging evidence for the latencies of earliest lexical and semantic information retrieval in visual word recognition. Participants performed lexical and semantic decisions (LD, SD) in a Go/NoGo paradigm. We introduced eye-blink latencies as a dependent variable, in order to measure behavioral responses that are faster and less variable than traditional button presses. We found that the earliest behavioral responses distinguishing stimulus categories can occur around 310 ms. Ex-Gaussian analysis of behavioral responses did not reveal reliable differences between LD and SD. The earliest ERP differences between Go and NoGo conditions occurred around 160 ms for both LD and SD. Distributed source analysis of combined EEG/MEG data estimated neuronal generators for the lexicality effect around 200 ms in the left anterior middle temporal lobe. Thus, behavior and brain responses provide coherent evidence that the brain starts retrieving lexical and semantic information near-simultaneously within 200 ms of word onset. Our results support models of word recognition that assume a continuous accumulation of task-related information from the stimulus, which might be described by Bayesian principles.

  8. Wide dynamic range neutron flux monitor having fast time response for the Large Helical Device.

    PubMed

    Isobe, M; Ogawa, K; Miyake, H; Hayashi, H; Kobuchi, T; Nakano, Y; Watanabe, K; Uritani, A; Misawa, T; Nishitani, T; Tomitaka, M; Kumagai, T; Mashiyama, Y; Ito, D; Kono, S; Yamauchi, M; Takeiri, Y

    2014-11-01

    A fast time response, wide dynamic range neutron flux monitor has been developed toward the LHD deuterium operation by using leading-edge signal processing technologies providing maximum counting rate up to ∼5 × 10(9) counts/s. Because a maximum total neutron emission rate over 1 × 10(16) n/s is predicted in neutral beam-heated LHD plasmas, fast response and wide dynamic range capabilities of the system are essential. Preliminary tests have demonstrated successful performance as a wide dynamic range monitor along the design.

  9. Wide dynamic range neutron flux monitor having fast time response for the Large Helical Device

    SciTech Connect

    Isobe, M. Takeiri, Y.; Ogawa, K.; Miyake, H.; Hayashi, H.; Kobuchi, T.; Nakano, Y.; Watanabe, K.; Uritani, A.; Misawa, T.; Nishitani, T.; Tomitaka, M.; Kumagai, T.; Mashiyama, Y.; Ito, D.; Kono, S.; Yamauchi, M.

    2014-11-15

    A fast time response, wide dynamic range neutron flux monitor has been developed toward the LHD deuterium operation by using leading-edge signal processing technologies providing maximum counting rate up to ∼5 × 10{sup 9} counts/s. Because a maximum total neutron emission rate over 1 × 10{sup 16} n/s is predicted in neutral beam-heated LHD plasmas, fast response and wide dynamic range capabilities of the system are essential. Preliminary tests have demonstrated successful performance as a wide dynamic range monitor along the design.

  10. Wide dynamic range neutron flux monitor having fast time response for the Large Helical Devicea)

    NASA Astrophysics Data System (ADS)

    Isobe, M.; Ogawa, K.; Miyake, H.; Hayashi, H.; Kobuchi, T.; Nakano, Y.; Watanabe, K.; Uritani, A.; Misawa, T.; Nishitani, T.; Tomitaka, M.; Kumagai, T.; Mashiyama, Y.; Ito, D.; Kono, S.; Yamauchi, M.; Takeiri, Y.

    2014-11-01

    A fast time response, wide dynamic range neutron flux monitor has been developed toward the LHD deuterium operation by using leading-edge signal processing technologies providing maximum counting rate up to ˜5 × 109 counts/s. Because a maximum total neutron emission rate over 1 × 1016 n/s is predicted in neutral beam-heated LHD plasmas, fast response and wide dynamic range capabilities of the system are essential. Preliminary tests have demonstrated successful performance as a wide dynamic range monitor along the design.

  11. Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects

    SciTech Connect

    Wolfe, R.R.; Peters, E.J.; Klein, S.; Holland, O.B.; Rosenblatt, J.; Gary, H. Jr.

    1987-02-01

    In this study the rate of lipolysis (fatty acid and glycerol release into blood) has been quantified in both normal weight and obese volunteers after both 15 and 87 h of fasting. In each study, the basal rate and subsequent response to epinephrine infusion were determined. The rate of appearance (R/sub a/) of free fatty acids (FFA) and glycerol were quantified by infusion of (1- TC)palmitate and D-5-glycerol, respectively. Substrate flux rates per unit of body fat mass and lean body mass were calculated from total body water measurements using H2 YO dilution. In normal volunteers, the basal R/sub a/ FFA and R/sub a/ glycerol rose markedly with 87 h of fasting, whereas the increases were more modest in the obese subjects. However, the rate of mobilization of fat, in relation to the lean body mass, was higher in the obese subjects than in the normal subjects after 15 h of fasting, and the values were similar in both groups after 87 h of fasting. There was an increased lipolytic response to epinephrine after fasting in both groups. This increased sensitivity may have resulted from the enhancement of fatty acid-triglyceride substrate cycling that occurred after fasting.

  12. Toward a Fast-Response Active Turbine Tip Clearance Control

    NASA Technical Reports Server (NTRS)

    Melcher, Kevin J.; Kypuros, Javier A.

    2003-01-01

    This paper describes active tip clearance control research being conducted by NASA to improve turbine engine systems. The target application for this effort is commercial aircraft engines. However, technologies developed for clearance control can benefit a broad spectrum of current and future turbomachinery. The first portion of the paper addresses the research from a programmatic viewpoint. Recent studies that provide motivation for the work, identification of key technologies, and NASA's plan for addressing deficiencies in the technologies are discussed. The later portion of the paper drills down into one of the key technologies by presenting equations and results for a preliminary dynamic model of the tip clearance phenomena.

  13. Is fast fiber innervation responsible for increased acetylcholinesterase activity in reinnervating soleus muscles?

    NASA Technical Reports Server (NTRS)

    Misulis, K. E.; Dettbarn, W. D.

    1985-01-01

    An investigation was conducted as to whether the predominantly slow SOL, which is low in AChE activity, is initially reinnervated by axons that originally innervated fast muscle fibers with high AChE activity, such as those of the EDL. Local denervation of the SOL in the guinea pig was performed because this muscle is composed solely of slow (type I) fibers; thereby virtually eliminating the possibility of homologous muscle fast fiber innervation. The overshoot in this preparation was qualitatively similar to that seen with distal denervation in the guinea pig and local and distal denervation in the rat. Thus, initial fast fiber innvervation is not responsible for the patterns of change in AChE activity seen with reinnervation in the SOL. It is concluded that the neural control of AChe is different in these two muscles and may reflect specific differences in the characteristics of AChE regulation in fast and slow muscle.

  14. Freddi: Fast Rise Exponential Decay accretion Disk model Implementation

    NASA Astrophysics Data System (ADS)

    Lipunova, G. V.; Malanchev, K. L.

    2016-10-01

    Freddi (Fast Rise Exponential Decay: accretion Disk model Implementation) solves 1-D evolution equations of the Shakura-Sunyaev accretion disk. It simulates fast rise exponential decay (FRED) light curves of low mass X-ray binaries (LMXBs). The basic equation of the viscous evolution relates the surface density and viscous stresses and is of diffusion type; evolution of the accretion rate can be found on solving the equation. The distribution of viscous stresses defines the emission from the source. The standard model for the accretion disk is implied; the inner boundary of the disk is at the ISCO or can be explicitely set. The boundary conditions in the disk are the zero stress at the inner boundary and the zero accretion rate at the outer boundary. The conditions are suitable during the outbursts in X-ray binary transients with black holes. In a binary system, the accretion disk is radially confined. In Freddi, the outer radius of the disk can be set explicitely or calculated as the position of the tidal truncation radius.

  15. Locomotion in response to shifting climate zones: not so fast.

    PubMed

    Feder, Martin E; Garland, Theodore; Marden, James H; Zera, Anthony J

    2010-01-01

    Although a species' locomotor capacity is suggestive of its ability to escape global climate change, such a suggestion is not necessarily straightforward. Species vary substantially in locomotor capacity, both ontogenetically and within/among populations, and much of this variation has a genetic basis. Accordingly, locomotor capacity can and does evolve rapidly, as selection experiments demonstrate. Importantly, even though this evolution of locomotor capacity may be rapid enough to escape changing climate, genetic correlations among traits (often due to pleiotropy) are such that successful or rapid dispersers are often limited in colonization or reproductive ability, which may be viewed as a trade-off. The nuanced assessment of this variation and evolution is reviewed for well-studied models: salmon, flying versus flightless insects, rodents undergoing experimental evolution, and metapopulations of butterflies. This work reveals how integration of physiology with population biology and functional genomics can be especially informative.

  16. Locomotion in response to shifting climate zones: not so fast.

    PubMed

    Feder, Martin E; Garland, Theodore; Marden, James H; Zera, Anthony J

    2010-01-01

    Although a species' locomotor capacity is suggestive of its ability to escape global climate change, such a suggestion is not necessarily straightforward. Species vary substantially in locomotor capacity, both ontogenetically and within/among populations, and much of this variation has a genetic basis. Accordingly, locomotor capacity can and does evolve rapidly, as selection experiments demonstrate. Importantly, even though this evolution of locomotor capacity may be rapid enough to escape changing climate, genetic correlations among traits (often due to pleiotropy) are such that successful or rapid dispersers are often limited in colonization or reproductive ability, which may be viewed as a trade-off. The nuanced assessment of this variation and evolution is reviewed for well-studied models: salmon, flying versus flightless insects, rodents undergoing experimental evolution, and metapopulations of butterflies. This work reveals how integration of physiology with population biology and functional genomics can be especially informative. PMID:20148672

  17. Fast model-based estimation of ancestry in unrelated individuals.

    PubMed

    Alexander, David H; Novembre, John; Lange, Kenneth

    2009-09-01

    Population stratification has long been recognized as a confounding factor in genetic association studies. Estimated ancestries, derived from multi-locus genotype data, can be used to perform a statistical correction for population stratification. One popular technique for estimation of ancestry is the model-based approach embodied by the widely applied program structure. Another approach, implemented in the program EIGENSTRAT, relies on Principal Component Analysis rather than model-based estimation and does not directly deliver admixture fractions. EIGENSTRAT has gained in popularity in part owing to its remarkable speed in comparison to structure. We present a new algorithm and a program, ADMIXTURE, for model-based estimation of ancestry in unrelated individuals. ADMIXTURE adopts the likelihood model embedded in structure. However, ADMIXTURE runs considerably faster, solving problems in minutes that take structure hours. In many of our experiments, we have found that ADMIXTURE is almost as fast as EIGENSTRAT. The runtime improvements of ADMIXTURE rely on a fast block relaxation scheme using sequential quadratic programming for block updates, coupled with a novel quasi-Newton acceleration of convergence. Our algorithm also runs faster and with greater accuracy than the implementation of an Expectation-Maximization (EM) algorithm incorporated in the program FRAPPE. Our simulations show that ADMIXTURE's maximum likelihood estimates of the underlying admixture coefficients and ancestral allele frequencies are as accurate as structure's Bayesian estimates. On real-world data sets, ADMIXTURE's estimates are directly comparable to those from structure and EIGENSTRAT. Taken together, our results show that ADMIXTURE's computational speed opens up the possibility of using a much larger set of markers in model-based ancestry estimation and that its estimates are suitable for use in correcting for population stratification in association studies.

  18. Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting

    PubMed Central

    Antonellis, Patrick Joseph; Hayes, Meghan Patricia; Adams, Andrew Charles

    2016-01-01

    Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carbohydrate metabolism. In the present study, we compared wild-type (WT) and FGF21-null (FGF21KO) mice, demonstrating that, despite the significant induction of FGF21 during fasting in the WT animals, our strain of FGF21-null mice exhibits only limited impairments in their adaptation to nutrient deprivation. Specifically, fasted FGF21KO mice display a mild attenuation of gluconeogenic transcriptional induction in the liver accompanied by partially blunted glucose production in response to a pyruvate challenge. Furthermore, FGF21KO mice displayed only minor impairments in lipid metabolism in the fasted state, limited to accumulation of hepatic triglycerides and a reduction in expression of genes associated with fatty acid oxidation. To address the possibility of compensation to germline deletion of FGF21, we further interrogated the role of endogenous FGF21 via acute pharmacological blockade of FGF21 signaling. At the transcriptional level, we show that FGF21 signaling is required for full induction of gluconeogenic and oxidative genes in the liver. However, corroborating our findings in FGF21KO mice, pharmacological blockade of the FGF21 axis did not profoundly disrupt the physiological response to fasting. Taken as a whole, these data demonstrate that, while FGF21 is partially required for appropriate gene expression during the fed to fasted transition, its absence does not significantly impact the downstream physiology of the fasted state. PMID:27445980

  19. Implicit XMHD Modeling of Fast Z-Pinches

    NASA Astrophysics Data System (ADS)

    Martin, Matthew

    2013-10-01

    The numerical modeling of fast Z-Pinches as applied to magnetically driven inertial confinement fusion concepts is typically performed under the resistive- magnetohydrodynamic (MHD) model. We derive the limitations of this model as currently applied to modeling such targets and present numerical test problems that demonstrate the physical error introduced through the approximations inherent in resistive-MHD. We then compare the resistive-MHD model to simulations utilizing new implicit algorithms for the efficient solution of the extended-magnetohydrodynamic (XMHD) system of equations. Herein we define XMHD as a quasi-neutral electro-magnetic two-fluid model. We present specific examples where the XMHD system of equations is required for modeling magnetically driven ICF targets if large physical errors are to be avoided in the numerical solution of the system. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  20. Wind turbine control systems: Dynamic model development using system identification and the fast structural dynamics code

    SciTech Connect

    Stuart, J.G.; Wright, A.D.; Butterfield, C.P.

    1996-10-01

    Mitigating the effects of damaging wind turbine loads and responses extends the lifetime of the turbine and, consequently, reduces the associated Cost of Energy (COE). Active control of aerodynamic devices is one option for achieving wind turbine load mitigation. Generally speaking, control system design and analysis requires a reasonable dynamic model of {open_quotes}plant,{close_quotes} (i.e., the system being controlled). This paper extends the wind turbine aileron control research, previously conducted at the National Wind Technology Center (NWTC), by presenting a more detailed development of the wind turbine dynamic model. In prior research, active aileron control designs were implemented in an existing wind turbine structural dynamics code, FAST (Fatigue, Aerodynamics, Structures, and Turbulence). In this paper, the FAST code is used, in conjunction with system identification, to generate a wind turbine dynamic model for use in active aileron control system design. The FAST code is described and an overview of the system identification technique is presented. An aileron control case study is used to demonstrate this modeling technique. The results of the case study are then used to propose ideas for generalizing this technique for creating dynamic models for other wind turbine control applications.

  1. Hormonal responses to extreme fasting in subantarctic fur seal (Arctocephalus tropicalis) pups.

    PubMed

    Verrier, Delphine; Atkinson, Shannon; Guinet, Christophe; Groscolas, René; Arnould, John P Y

    2012-04-15

    Surviving prolonged fasting implies closely regulated alterations in fuel provisioning to meet metabolic requirements, while preserving homeostasis. Little is known, however, of the endocrine regulations governing such metabolic adaptations in naturally fasting free-ranging animals. The hormonal responses to natural prolonged fasting and how they correlate to the metabolic adaptations observed, were investigated in subantarctic fur seal (Arctocephalus tropicalis) pups, which, because of the intermittent pattern of maternal attendance, repeatedly endure exceptionally long fasting episodes throughout their development (1-3 mo). Phase I fasting was characterized by a dramatic decrease in plasma insulin, glucagon, leptin, and total l-thyroxine (T(4)) associated with reductions in mass-specific resting metabolic rate (RMR), plasma triglycerides, glycerol, and urea-to-creatine ratio, while nonesterified fatty acids (NEFA) and β-OHB increased. In contrast, the metabolic steady-state of phase II fasting reached within 6 days was associated with minimal concentrations of insulin, glucagon, and leptin; unchanged cortisol and triiodothyronine (T(3)); and moderately increased T(4). The early fall in insulin and leptin may mediate the shift to the strategy of energy conservation, protein sparing, and primary reliance on body lipids observed in response to the cessation of feeding. In contrast to the typical mammalian starvation response, nonelevated cortisol and minimal glucagon levels may contribute to body protein preservation and downregulation of catabolic pathways, in general. Furthermore, thyroid hormones may be involved in a process of energy conservation, independent of pups' nutritional state. These original hormonal settings might reflect an adaptation to the otariid repeated fasting pattern and emphasize the crucial importance of a tight physiological control over metabolism to survive extreme energetic constraints.

  2. UNCOUPLING PROTEIN-2 MODULATES THE LIPID METABOLIC RESPONSE TO FASTING IN MICE

    PubMed Central

    Sheets, Anthony R.; Fülöp, Péter; Derdák, Zoltán; Kassai, Andrea; Sabo, Edmond; Mark, Nicholas M.; Paragh, György; Wands, Jack R.; Baffy, György

    2008-01-01

    Uncoupling protein-2 (UCP2) regulates insulin secretion by controlling ATP levels in β cells. While UCP2 deficiency improves glycemic control in mice, increased expression of UCP2 interferes with glucose-stimulated insulin secretion. These observations link UCP2 to β cell dysfunction in type 2 diabetes with a perplexing evolutionary role. We found higher residual serum insulin levels and blunted lipid metabolic responses in fasted ucp2−/− mice, supporting the concept that UCP2 evolved to suppress insulin effects and to accommodate the fuel switch to fatty acids during starvation. In the absence of UCP2, fasting initially promotes peripheral lipolysis and hepatic fat accumulation at less than expected rates, but culminates in protracted steatosis indicating diminished hepatic utilization and clearance of fatty acids. We conclude that UCP2-mediated control of insulin secretion is a physiologically relevant mechanism of the metabolic response to fasting. PMID:18292186

  3. Modelling land-fast sea ice using a linear elastic model

    NASA Astrophysics Data System (ADS)

    Plante, Mathieu; Tremblay, Bruno

    2016-04-01

    Land-fast ice is an important component of the Arctic system, capping the coastal Arctic waters for most of the year and exerting a large influence on ocean-atmosphere heat exchanges. Yet, the accurate representation of land-fast ice in most large-scale sea ice models remains a challenge, part due to the difficult (and sometimes non-physical) parametrisation of ice fracture. In this study, a linear elastic model is developed to investigate the internal stresses induced by the wind forcing on the land-fast ice, modelled as a 2D elastic plate. The model simulates ice fracture by the implementation of a damage coefficient which causes a local reduction in internal stress. This results in a cascade propagation of damage, simulating the ice fracture that determines the position of the land-fast ice edge. The modelled land-fast ice cover is sensitive to the choice of failure criterion. The parametrised cohesion, tensile and compressive strength and the relationship with the land-fast ice stability is discussed. To estimate the large scale mechanical properties of land-fast ice, these results are compared to a set of land-fast ice break up events and ice bridge formations observed in the Siberian Arctic. These events are identified using brightness temperature imagery from the MODIS (Moderate Resolution Imaging Spectroradiometer) Terra and Aqua satellites, from which the position of the flaw lead is identifiable by the opening of polynyi adjacent to the land-fast ice edge. The shape of the land-fast ice before, during and after these events, along with the characteristic scale of the resulting ice floes, are compared to the model results to extrapolate the stress state that corresponds to these observations. The model setting that best reproduce the scale of the observed break up events is used to provide an estimation of the strength of the ice relative to the wind forcing. These results will then be used to investigate the relationship between the ice thickness and the

  4. A Fast Hydrogen Sulfide-Releasing Donor Increases the Tumor Response to Radiotherapy.

    PubMed

    De Preter, Géraldine; Deriemaeker, Caroline; Danhier, Pierre; Brisson, Lucie; Cao Pham, Thanh Trang; Grégoire, Vincent; Jordan, Bénédicte F; Sonveaux, Pierre; Gallez, Bernard

    2016-01-01

    Hydrogen sulfide (H2S) is the last gaseous transmitter identified in mammals, and previous studies have reported disparate conclusions regarding the implication of H2S in cancer progression. In the present study, we hypothesized that sodium hydrosulfide (NaHS), a fast H2S-releasing donor, might interfere with the mitochondrial respiratory chain of tumor cells, increase tumor oxygenation, and potentiate the response to irradiation. Using electron paramagnetic resonance (EPR) oximetry, we found a rapid increase in tumor pO2 after NaHS administration (0.1 mmol/kg) in two human tumor models (breast MDA-MB-231 and cervix SiHa), an effect that was due to a decreased oxygen consumption and an increased tumor perfusion. Tumors irradiated 15 minutes after a single NaHS administration were more sensitive to irradiation compared with those that received irradiation alone (increase in growth delay by 50%). This radiosensitization was due to the oxygen effect, as the increased growth delay was abolished when temporarily clamped tumors were irradiated. In contrast, daily NaHS injection (0.1 mmol/kg/day for 14 days) did not provide any effect on tumor growth in vivo. To understand these paradoxical data, we analyzed the impact of external factors on the cellular response to NaHS. We found that extracellular pH had a dramatic effect on the cell response to NaHS, as the proliferation rate (measured in vitro by BrdU incorporation) was increased at pH = 7.4, but decreased at pH = 6.5. Overall, our study highlights the complex role of environmental components in the response of cancer cells to H2S and suggests a new approach for the use of H2S donors in combination with radiotherapy.

  5. Fast and stable numerical method for neuronal modelling

    NASA Astrophysics Data System (ADS)

    Hashemi, Soheil; Abdolali, Ali

    2016-11-01

    Excitable cell modelling is of a prime interest in predicting and targeting neural activity. Two main limits in solving related equations are speed and stability of numerical method. Since there is a tradeoff between accuracy and speed, most previously presented methods for solving partial differential equations (PDE) are focused on one side. More speed means more accurate simulations and therefore better device designing. By considering the variables in finite differenced equation in proper time and calculating the unknowns in the specific sequence, a fast, stable and accurate method is introduced in this paper for solving neural partial differential equations. Propagation of action potential in giant axon is studied by proposed method and traditional methods. Speed, consistency and stability of the methods are compared and discussed. The proposed method is as fast as forward methods and as stable as backward methods. Forward methods are known as fastest methods and backward methods are stable in any circumstances. Complex structures can be simulated by proposed method due to speed and stability of the method.

  6. INVESTIGATION OF OPEN-PATH FTIR FOR FAST DEPLOYMENT EMERGENCY RESPONSE TO CHEMICAL THREATS AND ACCIDENTS.

    EPA Science Inventory

    We have performed a series of experiments to determine the tradeoff in detection sensitivity for implementing design features for an Open-Path Fourier Transform Infrared (OP-FTIR) chemical analyzer that would be quick to deploy under emergency response conditions. The fast-deplo...

  7. Polylactide-based polyurethane shape memory nanocomposites (Fe3O4/PLAUs) with fast magnetic responsiveness

    NASA Astrophysics Data System (ADS)

    Gu, Shu-Ying; Jin, Sheng-Peng; Gao, Xie-Feng; Mu, Jian

    2016-05-01

    Polylactide-based polyurethane shape memory nanocomposites (Fe3O4/PLAUs) with fast magnetic responsiveness are presented. For the purpose of fast response and homogeneous dispersion of magnetic nanoparticles, oleic acid was used to improve the dispersibility of Fe3O4 nanoparticles in a polymer matrix. A homogeneous distribution of Fe3O4 nanoparticles in the polymer matrix was obtained for nanocomposites with low Fe3O4 loading content. A small agglomeration was observed for nanocomposites with 6 wt% and 9 wt% loading content, leading to a small decline in the mechanical properties. PLAU and its nanocomposites have glass transition around 52 °C, which can be used as the triggering temperature. PLAU and its nanocomposites have shape fixity ratios above 99%, shape recovery ratios above 82% for the first cycle and shape recovery ratios above 91% for the second cycle. PLAU and its nanocomposites also exhibit a fast water bath or magnetic responsiveness. The magnetic recovery time decreases with an increase in the loading content of Fe3O4 nanoparticles due to an improvement in heating performance for increased weight percentage of fillers. The nanocomposites have fast responses in an alternating magnetic field and have potential application in biomedical areas such as intravascular stent.

  8. Reasoning with Vectors: A Continuous Model for Fast Robust Inference

    PubMed Central

    Widdows, Dominic; Cohen, Trevor

    2015-01-01

    This paper describes the use of continuous vector space models for reasoning with a formal knowledge base. The practical significance of these models is that they support fast, approximate but robust inference and hypothesis generation, which is complementary to the slow, exact, but sometimes brittle behavior of more traditional deduction engines such as theorem provers. The paper explains the way logical connectives can be used in semantic vector models, and summarizes the development of Predication-based Semantic Indexing, which involves the use of Vector Symbolic Architectures to represent the concepts and relationships from a knowledge base of subject-predicate-object triples. Experiments show that the use of continuous models for formal reasoning is not only possible, but already demonstrably effective for some recognized informatics tasks, and showing promise in other traditional problem areas. Examples described in this paper include: predicting new uses for existing drugs in biomedical informatics; removing unwanted meanings from search results in information retrieval and concept navigation; type-inference from attributes; comparing words based on their orthography; and representing tabular data, including modelling numerical values. The algorithms and techniques described in this paper are all publicly released and freely available in the Semantic Vectors open-source software package.1 PMID:26582967

  9. Aroclor 1254 exposure reduces disease resistance and innate immune responses in fasted arctic charr

    USGS Publications Warehouse

    Maule, A.G.; Jorgensen, E.H.; Vijayan, M.M.; Killie, J.-E.A.

    2005-01-01

    To examine the immunological impacts of polychlorinated biphenyls (PCBs) in an environmentally relevant way, we orally contaminated Arctic charr (Salvelinus alpinus) with Aroclor 1254. After contamination, fish were either fed (0 and 100 mg Aroclor 1254 kg-1 fish wt) or fasted (0, 1, 10, and 100 mg kg-1) to mimic cycles of feeding-fasting experienced by Arctic animals. After four months, PCB concentrations in muscle were the same in fasted and fed fish; however, PCBs in kidneys of fed fish were 33 to 50% of those in fasted fish. Arctic charr were exposed to Aeromonas salmonicida, the bacteria responsible for furunculosis, by cohabitation with infected conspecifics. Fasted fish had a significant trend toward lower survival with higher dose of PCBs - from 68% in controls to 48% in treatment involving 100 mg kg-1. Independent of PCB contamination, fed fish had the lowest survival; we attribute this to stress associated with establishing and maintaining feeding hierarchies. A significant decrease in the activity of lysozyme was observed in skin mucus, as was hemagglutination ability of a putative rhamnose lectin in fasted, but not in fed, PCB-treated fish. These results demonstrate the immunosuppressive effects of PCBs on Arctic charr, and they illustrate the importance of considering environmentally relevant nutritional status in ecotoxicological studies.

  10. Unitary Response Regression Models

    ERIC Educational Resources Information Center

    Lipovetsky, S.

    2007-01-01

    The dependent variable in a regular linear regression is a numerical variable, and in a logistic regression it is a binary or categorical variable. In these models the dependent variable has varying values. However, there are problems yielding an identity output of a constant value which can also be modelled in a linear or logistic regression with…

  11. Feedback control indirect response models.

    PubMed

    Zhang, Yaping; D'Argenio, David Z

    2016-08-01

    A general framework is introduced for modeling pharmacodynamic processes that are subject to autoregulation, which combines the indirect response (IDR) model approach with methods from classical feedback control of engineered systems. The canonical IDR models are modified to incorporate linear combinations of feedback control terms related to the time course of the difference (the error signal) between the pharmacodynamic response and its basal value. Following the well-established approach of traditional engineering control theory, the proposed feedback control indirect response models incorporate terms proportional to the error signal itself, the integral of the error signal, the derivative of the error signal or combinations thereof. Simulations are presented to illustrate the types of responses produced by the proposed feedback control indirect response model framework, and to illustrate comparisons with other PK/PD modeling approaches incorporating feedback. In addition, four examples from literature are used to illustrate the implementation and applicability of the proposed feedback control framework. The examples reflect each of the four mechanisms of drug action as modeled by each of the four canonical IDR models and include: selective serotonin reuptake inhibitors and extracellular serotonin; histamine H2-receptor antagonists and gastric acid; growth hormone secretagogues and circulating growth hormone; β2-selective adrenergic agonists and potassium. The proposed feedback control indirect response approach may serve as an exploratory modeling tool and may provide a bridge for development of more mechanistic systems pharmacology models. PMID:27394724

  12. Training and Validation of the Fast PCRTM_Solar Model

    NASA Astrophysics Data System (ADS)

    Yang, Q.; Liu, X.; Wu, W.; Yang, P.; Wang, C.

    2015-12-01

    Fast and accurate radiative transfer model is the key for satellite data assimilation for remote sensing application. The simulation of the satellite remote sensing radiances is very complicated since many physical processes, such as absorption, emission, and scattering, are involved due to the interactions between electromagnetic radiation and earth surface, water vapor, clouds, aerosols, and gas molecules in the sky. The principal component-based radiative transfer model (PCRTM) has been developed for various passive IR and MW instruments. In this work, we extended PCRTM to including the contribution from solar radiation. The cloud/aerosol bidirectional reflectances have been carefully calculated using the well-known Discrete-Ordinate-Method Radiative Transfer (DISORT) model under over 10 millions of diverse conditions with varying cloud particle size, wavelength, satellite viewing direction, and solar angles. The obtained results were compressed significantly using principal component analysis and used in the mono domain radiance calculation. We used 1352 different atmosphere profiles, each of them has different surface skin temperatures and surface pressures in our training. Different surface emissivity spectra were derived from ASTER database and emissivity models. Some artificially generated emissivity spectra were also used to account for diverse surface types of the earth. Concentrations of sixteen trace gases were varied systematically in the training and the remaining trace gas contributions were accounted for as a fixed gas. Training was done in both clear and cloudy skies conditions. Finally the nonlocal thermal equilibrium (NLTE) induced radiance change was included for daytime conditions. We have updated the PCRTM model for instruments such as IASI, NASTI, CrIS, AIRS, and SHIS. The training results show that the PCRTM model can calculate thousands of channel radiances by computing only a few hundreds of mono radiances. This greatly increased the

  13. Gaining control over responses to implicit attitude tests: Implementation intentions engender fast responses on attitude-incongruent trials.

    PubMed

    Webb, Thomas L; Sheeran, Paschal; Pepper, John

    2012-03-01

    The present research investigated whether forming implementation intentions could promote fast responses to attitude-incongruent associations (e.g., woman-manager) and thereby modify scores on popular implicit measures of attitude. Expt 1 used the Implicit Association Test (IAT) to measure associations between gender and science versus liberal arts. Planning to associate women with science engendered fast responses to this category-attribute pairing and rendered summary scores more neutral compared to standard IAT instructions. Expt 2 demonstrated that forming egalitarian goal intentions is not sufficient to produce these effects. Expt 3 extended these findings to a different measure of implicit attitude (the Go/No-Go Association Task) and a different stereotypical association (Muslims-terrorism). In Expt 4, managers who planned to associate women with superordinate positions showed more neutral IAT scores relative to non-planners and effects were maintained 3 weeks later. In sum, implementation intentions enable people to gain control over implicit attitude responses.

  14. Gaining control over responses to implicit attitude tests: Implementation intentions engender fast responses on attitude-incongruent trials.

    PubMed

    Webb, Thomas L; Sheeran, Paschal; Pepper, John

    2012-03-01

    The present research investigated whether forming implementation intentions could promote fast responses to attitude-incongruent associations (e.g., woman-manager) and thereby modify scores on popular implicit measures of attitude. Expt 1 used the Implicit Association Test (IAT) to measure associations between gender and science versus liberal arts. Planning to associate women with science engendered fast responses to this category-attribute pairing and rendered summary scores more neutral compared to standard IAT instructions. Expt 2 demonstrated that forming egalitarian goal intentions is not sufficient to produce these effects. Expt 3 extended these findings to a different measure of implicit attitude (the Go/No-Go Association Task) and a different stereotypical association (Muslims-terrorism). In Expt 4, managers who planned to associate women with superordinate positions showed more neutral IAT scores relative to non-planners and effects were maintained 3 weeks later. In sum, implementation intentions enable people to gain control over implicit attitude responses. PMID:22435844

  15. Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake.

    PubMed

    Mathew, Sweety; Krug, Susanne; Skurk, Thomas; Halama, Anna; Stank, Antonia; Artati, Anna; Prehn, Cornelia; Malek, Joel A; Kastenmüller, Gabi; Römisch-Margl, Werner; Adamski, Jerzy; Hauner, Hans; Suhre, Karsten

    2014-06-06

    High-throughput screening techniques that analyze the metabolic endpoints of biological processes can identify the contributions of genetic predisposition and environmental factors to the development of common diseases. Studies applying controlled physiological challenges can reveal dysregulation in metabolic responses that may be predictive for or associated with these diseases. However, large-scale epidemiological studies with well controlled physiological challenge conditions, such as extended fasting periods and defined food intake, pose logistic challenges. Culturally and religiously motivated behavioral patterns of life style changes provide a natural setting that can be used to enroll a large number of study volunteers. Here we report a proof of principle study conducted within a Muslim community, showing that a metabolomics study during the Holy Month of Ramadan can provide a unique opportunity to explore the pre-prandial and postprandial response of human metabolism to nutritional challenges. Up to five blood samples were obtained from eleven healthy male volunteers, taken directly before and two hours after consumption of a controlled meal in the evening on days 7 and 26 of Ramadan, and after an over-night fast several weeks after Ramadan. The observed increases in glucose, insulin and lactate levels at the postprandial time point confirm the expected physiological response to food intake. Targeted metabolomics further revealed significant and physiologically plausible responses to food intake by an increase in bile acid and amino acid levels and a decrease in long-chain acyl-carnitine and polyamine levels. A decrease in the concentrations of a number of phospholipids between samples taken on days 7 and 26 of Ramadan shows that the long-term response to extended fasting may differ from the response to short-term fasting. The present study design is scalable to larger populations and may be extended to the study of the metabolic response in defined patient

  16. Fast structural responses of gap junction membrane domains to AB5 toxins.

    PubMed

    Majoul, Irina V; Gao, Liang; Betzig, Eric; Onichtchouk, Daria; Butkevich, Eugenia; Kozlov, Yuri; Bukauskas, Feliksas; Bennett, Michael V L; Lippincott-Schwartz, Jennifer; Duden, Rainer

    2013-10-29

    Gap junctions (GJs) represent connexin-rich membrane domains that connect interiors of adjoining cells in mammalian tissues. How fast GJs can respond to bacterial pathogens has not been known previously. Using Bessel beam plane illumination and confocal spinning disk microscopy, we found fast (~500 ms) formation of connexin-depleted regions (CDRs) inside GJ plaques between cells exposed to AB5 toxins. CDR formation appears as a fast redistribution of connexin channels within GJ plaques with minor changes in outline or geometry. CDR formation does not depend on membrane trafficking or submembrane cytoskeleton and has no effect on GJ conductance. However, CDR responses depend on membrane lipids, can be modified by cholesterol-clustering agents and extracellular K(+) ion concentration, and influence cAMP signaling. The CDR response of GJ plaques to bacterial toxins is a phenomenon observed for all tested connexin isoforms. Through signaling, the CDR response may enable cells to sense exposure to AB5 toxins. CDR formation may reflect lipid-phase separation events in the biological membrane of the GJ plaque, leading to increased connexin packing and lipid reorganization. Our data demonstrate very fast dynamics (in the millisecond-to-second range) within GJ plaques, which previously were considered to be relatively stable, long-lived structures.

  17. Fast Responsive Gas Sensor of Vertically Aligned Fluorine-Doped Tin Oxide Nanorod Thin Film

    NASA Astrophysics Data System (ADS)

    Cho, Chan-Woo; Lee, Jong-Heun; Riu, Doh-Hyung; Kim, Chang-Yeoul

    2012-04-01

    We prepared fluorine-doped tin oxide (FTO) nanorod films and a conventional FTO thin film for the application of a semiconducting gas sensor by spray pyrolysis method. The lengths of FTO nanorods (FTON, 100 and 500 nm) were controlled by changing deposition times, and FTO thin film (FTOT) was also prepared as a reference. The gas sensitivity test shows FTON with long nanorods had higher sensitivity for both hydrogen and ethanol gases but slow response and recovery times, despite an advantage of the higher gas sensitivity. FTO nanorod film with short length about 100 nm showed relatively lower sensitivity, but fast gas response and recovery characteristics. The fast response and recovery for the analyte gases are attributed to the conductance of FTO nanorods, which is closely related to the diameter and length of nanorods.

  18. Fast background subtraction for moving cameras based on nonparametric models

    NASA Astrophysics Data System (ADS)

    Sun, Feng; Qin, Kaihuai; Sun, Wei; Guo, Huayuan

    2016-05-01

    In this paper, a fast background subtraction algorithm for freely moving cameras is presented. A nonparametric sample consensus model is employed as the appearance background model. The as-similar-as-possible warping technique, which obtains multiple homographies for different regions of the frame, is introduced to robustly estimate and compensate the camera motion between the consecutive frames. Unlike previous methods, our algorithm does not need any preprocess step for computing the dense optical flow or point trajectories. Instead, a superpixel-based seeded region growing scheme is proposed to extend the motion cue based on the sparse optical flow to the entire image. Then, a superpixel-based temporal coherent Markov random field optimization framework is built on the raw segmentations from the background model and the motion cue, and the final background/foreground labels are obtained using the graph-cut algorithm. Extensive experimental evaluations show that our algorithm achieves satisfactory accuracy, while being much faster than the state-of-the-art competing methods.

  19. Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women.

    PubMed

    Moazzami, Ali A; Shrestha, Aahana; Morrison, David A; Poutanen, Kaisa; Mykkänen, Hannu

    2014-06-01

    Changes in serum metabolic profile after the intake of different food products (e.g., bread) can provide insight into their interaction with human metabolism. Postprandial metabolic responses were compared after the intake of refined wheat (RWB), whole-meal rye (WRB), and refined rye (RRB) breads. In addition, associations between the metabolic profile in fasting serum and the postprandial concentration of insulin in response to different breads were investigated. Nineteen postmenopausal women with normal fasting glucose and normal glucose tolerance participated in a randomized, controlled, crossover meal study. The test breads, RWB (control), RRB, and WRB, providing 50 g of available carbohydrate, were each served as a single meal. The postprandial metabolic profile was measured using nuclear magnetic resonance and targeted LC-mass spectrometry and was compared between different breads using ANOVA and multivariate models. Eight amino acids had a significant treatment effect (P < 0.01) and a significant treatment × time effect (P < 0.05). RWB produced higher postprandial concentrations of leucine (geometric mean: 224; 95% CI: 196, 257) and isoleucine (mean ± SD: 111 ± 31.5) compared with RRB (geometric mean: 165; 95% CI: 147, 186; mean ± SD: 84.2 ± 22.9) and WRB (geometric mean: 190; 95% CI: 174, 207; mean ± SD: 95.8 ± 17.3) at 60 min respectively (P < 0.001). In addition, 2 metabolic subgroups were identified using multivariate models based on the association between fasting metabolic profile and the postprandial concentration of insulin. Women with higher fasting concentrations of leucine and isoleucine and lower fasting concentrations of sphingomyelins and phosphatidylcholines had higher insulin responses despite similar glucose concentration after all kinds of bread (cross-validated ANOVA, P = 0.048). High blood concentration of branched-chain amino acids, i.e., leucine and isoleucine, has been associated with the increased risk of diabetes, which

  20. Fast response hydrogen sensors based on anodic aluminum oxide with pore-widening treatment

    NASA Astrophysics Data System (ADS)

    Wu, Shuanghong; Zhou, Han; Hao, Mengmeng; Wei, Xiongbang; Li, Shibin; Yu, He; Wang, Xiangru; Chen, Zhi

    2016-09-01

    Fast response hydrogen sensors operating at room temperature based on nanoporous palladium (Pd) films supported by treated anodic aluminum oxide (AAO) template have been demonstrated. It was found that the nanoporous Pd film had a quicker and reversible response by a 30-min pore-widening treatment of the AAO template, due to its faster absorption and desorption of hydrogen. We obtained a sensor response time as short as 14 s at 1.4% hydrogen concentration with the 30-min pore-widening treatment of AAO template. The sensor exhibited very good performance at hydrogen concentrations from 0.1% to 2%.

  1. A Fast Infrared Radiative Transfer Model for Overlapping Clouds

    NASA Technical Reports Server (NTRS)

    Niu, Jianguo; Yang, Ping; Huang, Huang-Lung; Davies, James E.; Li, Jun; Baum, Bryan A.; Hu, Yong X.

    2006-01-01

    A fast infrared radiative transfer model (FIRTM2) appropriate for application to both single-layered and overlapping cloud situations is developed for simulating the outgoing infrared spectral radiance at the top of the atmosphere (TOA). In FIRTM2 a pre-computed library of cloud reflectance and transmittance values is employed to account for one or two cloud layers, whereas the background atmospheric optical thickness due to gaseous absorption can be computed from a clear-sky radiative transfer model. FIRTM2 is applicable to three atmospheric conditions: 1) clear-sky, 2) single-layered ice or water cloud, and 3) two simultaneous cloud layers in a column (e.g., ice cloud overlying water cloud). Moreover, FIRTM2 outputs the derivatives (i.e., Jacobians) of the TOA brightness temperature with respect to cloud optical thickness and effective particle size. Sensitivity analyses have been carried out to assess the performance of FIRTM2 for two spectral regions, namely the longwave (LW) band (587.3 - 1179.5/cm) and the short-to-medium wave (SMW) band (1180.1 - 2228.9/cm). The assessment is carried out in terms of brightness temperature differences (BTD) between FIRTM2 and the well-known discrete ordinates radiative transfer model (DISORT), henceforth referred to as BTD (F-D). The BTD (F-D) values for single-layered clouds are generally less than 0.8 K. For the case of two cloud layers (specifically ice cloud over water cloud), the BTD(F-D) values are also generally less than 0.8 K except for the SMW band for the case of a very high altitude (>15 km) cloud comprised of small ice particles. Note that for clear-sky atmospheres, FIRTM2 reduces to the clear-sky radiative transfer model that is incorporated into FIRTM2, and the errors in this case are essentially those of the clear-sky radiative transfer model.

  2. Building and Calibration of a FAST Model of the SWAY Prototype Floating Wind Turbine: Preprint

    SciTech Connect

    Koh, J. H.; Robertson, A.; Jonkman, J.; Driscoll, F.; Ng, E. Y. K.

    2013-09-01

    Present efforts to verify and validate aero-hydro-servo-elastic numerical simulation tools that predict the dynamic response of a floating offshore wind turbine are primarily limited to code-to-code comparisons or code-to-data comparisons using data from wind-wave basin tests. In partnership with SWAY AS, the National Renewable Energy Laboratory (NREL) installed scientific wind, wave, and motion measurement equipment on the 1/6.5th-scale prototype SWAY floating wind system to collect data to validate a FAST model of the SWAY design in an open-water condition. Nanyang Technological University (NTU), through a collaboration with NREL, assisted in this validation.

  3. Wavenumber-frequency Spectra of Pressure Fluctuations Measured via Fast Response Pressure Sensitive Paint

    NASA Technical Reports Server (NTRS)

    Panda, J.; Roozeboom, N. H.; Ross, J. C.

    2016-01-01

    The recent advancement in fast-response Pressure-Sensitive Paint (PSP) allows time-resolved measurements of unsteady pressure fluctuations from a dense grid of spatial points on a wind tunnel model. This capability allows for direct calculations of the wavenumber-frequency (k-?) spectrum of pressure fluctuations. Such data, useful for the vibro-acoustics analysis of aerospace vehicles, are difficult to obtain otherwise. For the present work, time histories of pressure fluctuations on a flat plate subjected to vortex shedding from a rectangular bluff-body were measured using PSP. The light intensity levels in the photographic images were then converted to instantaneous pressure histories by applying calibration constants, which were calculated from a few dynamic pressure sensors placed at selective points on the plate. Fourier transform of the time-histories from a large number of spatial points provided k-? spectra for pressure fluctuations. The data provides first glimpse into the possibility of creating detailed forcing functions for vibro-acoustics analysis of aerospace vehicles, albeit for a limited frequency range.

  4. Fast-response underwater TSP investigation of subcritical instabilities of a cylinder in crossflow

    NASA Astrophysics Data System (ADS)

    Capone, Alessandro; Klein, Christian; Di Felice, Fabio; Beifuss, Uwe; Miozzi, Massimo

    2015-10-01

    We investigate the classic cylinder in crossflow case to test the effectiveness of a fast-response underwater temperature-sensitive paint coating (TSP) in providing highly resolved spatial and time observations of the action of a flow over a bluff body surface. The flow is investigated at Reynolds number <190 k, before the onset of the drag-crisis state. The obtained TSP image sequences convey an accurate description of the evolution of the main features in the fluid-cylinder interaction, like the separation line position, the pattern of the large coherent structures acting on the cylinder's surface and the small-scale intermittent streamwise arrays of vortices. Ad hoc data management and features extraction techniques are proposed which allow extraction of quantitative data, such as separation line position and vortex-shedding frequency, and results are compared to the literature. Use of TSP for water applications introduces an interesting point of view about the fluid-body interactions by focusing directly on the effect of the flow on the model surface.

  5. Model refinement using transient response

    SciTech Connect

    Dohrmann, C.R.; Carne, T.G.

    1997-12-01

    A method is presented for estimating uncertain or unknown parameters in a mathematical model using measurements of transient response. The method is based on a least squares formulation in which the differences between the model and test-based responses are minimized. An application of the method is presented for a nonlinear structural dynamic system. The method is also applied to a model of the Department of Energy armored tractor trailer. For the subject problem, the transient response was generated by driving the vehicle over a bump of prescribed shape and size. Results from the analysis and inspection of the test data revealed that a linear model of the vehicle`s suspension is not adequate to accurately predict the response caused by the bump.

  6. Fast Virtual Stenting with Active Contour Models in Intracranical Aneurysm.

    PubMed

    Zhong, Jingru; Long, Yunling; Yan, Huagang; Meng, Qianqian; Zhao, Jing; Zhang, Ying; Yang, Xinjian; Li, Haiyun

    2016-02-15

    Intracranial stents are becoming increasingly a useful option in the treatment of intracranial aneurysms (IAs). Image simulation of the releasing stent configuration together with computational fluid dynamics (CFD) simulation prior to intervention will help surgeons optimize intervention scheme. This paper proposed a fast virtual stenting of IAs based on active contour model (ACM) which was able to virtually release stents within any patient-specific shaped vessel and aneurysm models built on real medical image data. In this method, an initial stent mesh was generated along the centerline of the parent artery without the need for registration between the stent contour and the vessel. Additionally, the diameter of the initial stent volumetric mesh was set to the maximum inscribed sphere diameter of the parent artery to improve the stenting accuracy and save computational cost. At last, a novel criterion for terminating virtual stent expanding that was based on the collision detection of the axis aligned bounding boxes was applied, making the stent expansion free of edge effect. The experiment results of the virtual stenting and the corresponding CFD simulations exhibited the efficacy and accuracy of the ACM based method, which are valuable to intervention scheme selection and therapy plan confirmation.

  7. MACULA: Fast Modeling of Rotational Modulations of Spotty Stars

    NASA Astrophysics Data System (ADS)

    Kipping, David

    2015-08-01

    Rotational modulations are frequently observed on stars observed by photometry surveys such as Kepler, with periodicities ranging from days to months and amplitudes of sub-parts-per-million to several percent. These variations may be studied to reveal important stellar properties such as rotational periods, inclinations and gradients of differential rotation. However, inverting the disk-integrated flux into a solution for spot number, sizes, contrasts, etc is highly degenerate and thereby necessitating an exhaustive search of the parameter space. In recognition of this, the software MACULA is designed to be a fast forward model of circular, grey spots on rotating stars, including effects such as differential rotation, spot evolution and even spot penumbra/umbra. MACULA seeks to achieve computational efficiency by using a wholly analytic description of the disk-integrated flux, which is described in Kipping (2012), leading to a computational improvement of three orders-of-magnitude over its numerical counterparts. As part of the hack day, I'll show how to simulate light curves with MACULA and provide examples with visualizations. I will also discuss the on-going development of the code, which will head towards modeling spot crossing events and radial velocity jitter and I encourage discussions amongst the participants on analytic methods to this end.

  8. Fast Virtual Stenting with Active Contour Models in Intracranical Aneurysm

    PubMed Central

    Zhong, Jingru; Long, Yunling; Yan, Huagang; Meng, Qianqian; Zhao, Jing; Zhang, Ying; Yang, Xinjian; Li, Haiyun

    2016-01-01

    Intracranial stents are becoming increasingly a useful option in the treatment of intracranial aneurysms (IAs). Image simulation of the releasing stent configuration together with computational fluid dynamics (CFD) simulation prior to intervention will help surgeons optimize intervention scheme. This paper proposed a fast virtual stenting of IAs based on active contour model (ACM) which was able to virtually release stents within any patient-specific shaped vessel and aneurysm models built on real medical image data. In this method, an initial stent mesh was generated along the centerline of the parent artery without the need for registration between the stent contour and the vessel. Additionally, the diameter of the initial stent volumetric mesh was set to the maximum inscribed sphere diameter of the parent artery to improve the stenting accuracy and save computational cost. At last, a novel criterion for terminating virtual stent expanding that was based on the collision detection of the axis aligned bounding boxes was applied, making the stent expansion free of edge effect. The experiment results of the virtual stenting and the corresponding CFD simulations exhibited the efficacy and accuracy of the ACM based method, which are valuable to intervention scheme selection and therapy plan confirmation. PMID:26876026

  9. Evaluation of nonlinear structural dynamic responses using a fast-running spring-mass formulation

    SciTech Connect

    Benjamin, A.S.; Altman, B.S.; Gruda, J.D.

    1995-03-01

    In today`s world, accurate finite-element simulations of large nonlinear systems may require meshes composed of hundreds of thousands of degrees of freedom. Even with today`s fast computers and the promise of ever-faster ones in the future, central processing unit (CPU) expenditures for such problems could be measured in days. Many contemporary engineering problems, such as those found in risk assessment, probabilistic structural analysis, and structural design optimization, cannot tolerate the cost or turnaround time for such CPU-intensive analyses, because these applications require a large number of cases to be run with different inputs. For many risk assessment applications, analysts would prefer running times to be measurable in minutes. There is therefore a need for approximation methods which can solve such problems far more efficiently than the very detailed methods and yet maintain an acceptable degree of accuracy. For this purpose, we have been working on two methods of approximation: neural networks and spring-mass models. This paper presents our work and results to date for spring-mass modeling and analysis, since we are further along in this area than in the neural network formulation. It describes the physical and numerical models contained in a code we developed called STRESS, which stands for ``Spring-mass Transient Response Evaluation for structural Systems``. The paper also presents results for a demonstration problem, and compares these with results obtained for the same problem using PRONTO3D, a state-of-the-art finite element code which was also developed at Sandia.

  10. Response of six neutron survey meters in mixed fields of fast and thermal neutrons.

    PubMed

    Kim, S I; Kim, B H; Chang, I; Lee, J I; Kim, J L; Pradhan, A S

    2013-10-01

    Calibration neutron fields have been developed at KAERI (Korea Atomic Energy Research Institute) to study the responses of commonly used neutron survey meters in the presence of fast neutrons of energy around 10 MeV. The neutron fields were produced by using neutrons from the (241)Am-Be sources held in a graphite pile and a DT neutron generator. The spectral details and the ambient dose equivalent rates of the calibration fields were established, and the responses of six neutron survey meters were evaluated. Four single-moderator-based survey meters exhibited an under-responses ranging from ∼9 to 55 %. DINEUTRUN, commonly used in fields around nuclear reactors, exhibited an over-response by a factor of three in the thermal neutron field and an under-response of ∼85 % in the mixed fields. REM-500 (tissue-equivalent proportional counter) exhibited a response close to 1.0 in the fast neutron fields and an under-response of ∼50 % in the thermal neutron field.

  11. Biased Randomized Algorithm for Fast Model-Based Diagnosis

    NASA Technical Reports Server (NTRS)

    Williams, Colin; Vartan, Farrokh

    2005-01-01

    A biased randomized algorithm has been developed to enable the rapid computational solution of a propositional- satisfiability (SAT) problem equivalent to a diagnosis problem. The closest competing methods of automated diagnosis are described in the preceding article "Fast Algorithms for Model-Based Diagnosis" and "Two Methods of Efficient Solution of the Hitting-Set Problem" (NPO-30584), which appears elsewhere in this issue. It is necessary to recapitulate some of the information from the cited articles as a prerequisite to a description of the present method. As used here, "diagnosis" signifies, more precisely, a type of model-based diagnosis in which one explores any logical inconsistencies between the observed and expected behaviors of an engineering system. The function of each component and the interconnections among all the components of the engineering system are represented as a logical system. Hence, the expected behavior of the engineering system is represented as a set of logical consequences. Faulty components lead to inconsistency between the observed and expected behaviors of the system, represented by logical inconsistencies. Diagnosis - the task of finding the faulty components - reduces to finding the components, the abnormalities of which could explain all the logical inconsistencies. One seeks a minimal set of faulty components (denoted a minimal diagnosis), because the trivial solution, in which all components are deemed to be faulty, always explains all inconsistencies. In the methods of the cited articles, the minimal-diagnosis problem is treated as equivalent to a minimal-hitting-set problem, which is translated from a combinatorial to a computational problem by mapping it onto the Boolean-satisfiability and integer-programming problems. The integer-programming approach taken in one of the prior methods is complete (in the sense that it is guaranteed to find a solution if one exists) and slow and yields a lower bound on the size of the

  12. Fast-response, high-precision carbon monoxide sensor using a tunable diode laser absorption technique

    NASA Technical Reports Server (NTRS)

    Sachse, Glen W.; Hill, Gerald F.; Wade, Larry O.; Perry, Murray G.

    1987-01-01

    A tunable diode laser instrument, denoted as DACOM (Differential Absorption CO Measurement), has been developed to meet the fast-response, high-precision CO measurement needs of the GTE (Global Tropospheric Experiment) program. Under the GTE program, DACOM participated in the three field missions of CITE 1 (Chemical Instrumentation Test and Evaluation 1), a project involving the intercomparison of trace gas measurement techniques. DACOM performance, including analyses of measurement error sources, is discussed for the ground-based mission at Wallops Island, VA (summer 1983), and two missions on the NASA CV-990 (fall 1983 and spring 1984). Examples of fast-response (about 1 s), high-precision (+ or - 1 part per billion by volume, + or - 1.5 percent of reading) airborne data are included to illustrate the capability of this instrument.

  13. A novel WV film for fast-response-time OCB-LCD

    NASA Astrophysics Data System (ADS)

    Matsubara, Ryota; Ito, Yoji; Nakamura, Shun; Mori, Hiroyuki; Mihayashi, Keiji

    2006-02-01

    We have successfully developed and commercialized an optical compensation film for OCB-LCD mode (OCB-WV film). OCB-LCD mode is known to have a very fast optical response time and makes next-generation fast-response LCD-TVs possible and free from image blurring. The OCB-WV film, which has a structure composed with TAC (triacetyl cellulose) film and PDM (polymerized discotic material) layer, can realize the wide viewing angle of OCB-cell. In order to provide the best performance of OCB-cell, we optimized an optical parameter of not only WV film but also OCB cell by a numerical simulation. In this paper, we will discuss a concept of its optimization, which provide excellent results of a numerical simulation.

  14. Fast Prediction and Evaluation of Gravitational Waveforms Using Surrogate Models

    NASA Astrophysics Data System (ADS)

    Field, Scott E.; Galley, Chad R.; Hesthaven, Jan S.; Kaye, Jason; Tiglio, Manuel

    2014-07-01

    We propose a solution to the problem of quickly and accurately predicting gravitational waveforms within any given physical model. The method is relevant for both real-time applications and more traditional scenarios where the generation of waveforms using standard methods can be prohibitively expensive. Our approach is based on three offline steps resulting in an accurate reduced order model in both parameter and physical dimensions that can be used as a surrogate for the true or fiducial waveform family. First, a set of m parameter values is determined using a greedy algorithm from which a reduced basis representation is constructed. Second, these m parameters induce the selection of m time values for interpolating a waveform time series using an empirical interpolant that is built for the fiducial waveform family. Third, a fit in the parameter dimension is performed for the waveform's value at each of these m times. The cost of predicting L waveform time samples for a generic parameter choice is of order O(mL+mcfit) online operations, where cfit denotes the fitting function operation count and, typically, m ≪L. The result is a compact, computationally efficient, and accurate surrogate model that retains the original physics of the fiducial waveform family while also being fast to evaluate. We generate accurate surrogate models for effective-one-body waveforms of nonspinning binary black hole coalescences with durations as long as 105M, mass ratios from 1 to 10, and for multiple spherical harmonic modes. We find that these surrogates are more than 3 orders of magnitude faster to evaluate as compared to the cost of generating effective-one-body waveforms in standard ways. Surrogate model building for other waveform families and models follows the same steps and has the same low computational online scaling cost. For expensive numerical simulations of binary black hole coalescences, we thus anticipate extremely large speedups in generating new waveforms with a

  15. FMFilter: A fast model based variant filtering tool.

    PubMed

    Akgün, Mete; Faruk Gerdan, Ö; Görmez, Zeliha; Demirci, Hüseyin

    2016-04-01

    The availability of whole exome and genome sequencing has completely changed the structure of genetic disease studies. It is now possible to solve the disease causing mechanisms within shorter time and budgets. For this reason, mining out the valuable information from the huge amount of data produced by next generation techniques becomes a challenging task. Current tools analyze sequencing data in various methods. However, there is still need for fast, easy to use and efficacious tools. Considering genetic disease studies, there is a lack of publicly available tools which support compound heterozygous and de novo models. Also, existing tools either require advanced IT expertise or are inefficient for handling large variant files. In this work, we provide FMFilter, an efficient sieving tool for next generation sequencing data produced by genetic disease studies. We develop a software which allows to choose the inheritance model (recessive, dominant, compound heterozygous and de novo), the affected and control individuals. The program provides a user friendly Graphical User Interface which eliminates the requirement of advanced computer techniques. It has various filtering options which enable to eliminate the majority of the false alarms. FMFilter requires negligible memory, therefore it can easily handle very large variant files like multiple whole genomes with ordinary computers. We demonstrate the variant reduction capability and effectiveness of the proposed tool with public and in-house data for different inheritance models. We also compare FMFilter with the existing filtering software. We conclude that FMFilter provides an effective and easy to use environment for analyzing next generation sequencing data from Mendelian diseases. PMID:26925517

  16. FMFilter: A fast model based variant filtering tool.

    PubMed

    Akgün, Mete; Faruk Gerdan, Ö; Görmez, Zeliha; Demirci, Hüseyin

    2016-04-01

    The availability of whole exome and genome sequencing has completely changed the structure of genetic disease studies. It is now possible to solve the disease causing mechanisms within shorter time and budgets. For this reason, mining out the valuable information from the huge amount of data produced by next generation techniques becomes a challenging task. Current tools analyze sequencing data in various methods. However, there is still need for fast, easy to use and efficacious tools. Considering genetic disease studies, there is a lack of publicly available tools which support compound heterozygous and de novo models. Also, existing tools either require advanced IT expertise or are inefficient for handling large variant files. In this work, we provide FMFilter, an efficient sieving tool for next generation sequencing data produced by genetic disease studies. We develop a software which allows to choose the inheritance model (recessive, dominant, compound heterozygous and de novo), the affected and control individuals. The program provides a user friendly Graphical User Interface which eliminates the requirement of advanced computer techniques. It has various filtering options which enable to eliminate the majority of the false alarms. FMFilter requires negligible memory, therefore it can easily handle very large variant files like multiple whole genomes with ordinary computers. We demonstrate the variant reduction capability and effectiveness of the proposed tool with public and in-house data for different inheritance models. We also compare FMFilter with the existing filtering software. We conclude that FMFilter provides an effective and easy to use environment for analyzing next generation sequencing data from Mendelian diseases.

  17. Fast desensitization of the response to InsP3 in Limulus ventral photoreceptors.

    PubMed Central

    Levitan, I; Hillman, P; Payne, R

    1993-01-01

    In Limulus ventral photoreceptor cells the time-course of the desensitization of InsP3 response was measured by an injection-pair paradigm. Pressure pulses of InsP3 were delivered into the cell with various interpulse intervals. The desensitization of the response to the second injection of each pair approached totality at 200 ms, which is the duration of the response to a single pressure pulse of InsP3. Lowering extracellular calcium did not affect the time-course of the desensitization. Lowering the temperature slowed down both the time-course of the response to InsP3 and the time-course of the desensitization to the same extent. These findings suggest that the desensitization is powerful enough and its onset fast enough to contribute to the transience of the InsP3 response. The time-course of the desensitization suggests it may influence light adaptation. PMID:8494989

  18. The thermoluminescence response of doped SiO2 optical fibres subjected to fast neutrons.

    PubMed

    Hashim, S; Bradley, D A; Saripan, M I; Ramli, A T; Wagiran, H

    2010-01-01

    This paper describes a preliminary study of the thermoluminescence (TL) response of doped SiO(2) optical fibres subjected to (241)AmBe neutron irradiation. The TL materials, which comprise Al- and Ge-doped silica fibres, were exposed in close contact with the (241)AmBe source to obtain fast neutron interactions through use of measurements obtained with and without a Cd filter (the filter being made to entirely enclose the fibres). The neutron irradiations were performed for exposure times of 1-, 2-, 3-, 5- and 7-days in a neutron tank filled with water. In this study, use was also made of the Monte Carlo N-particle (MCNP) code version 5 (V5) to simulate the neutron irradiations experiment. It was found that the commercially available Ge-doped and Al-doped optical fibres show a linear dose response subjected to fast neutrons from (241)AmBe source up to seven days of irradiations. The simulation performed using MCNP5 also exhibits a similar pattern, albeit differing in sensitivity. The TL response of Ge-doped fibre is markedly greater than that of the Al-doped fibre, the total absorption cross section for Ge in both the fast and thermal neutrons region being some ten times greater than that of Al.

  19. Models of coronal heating, turbulence and fast reconnection.

    PubMed

    Velli, M; Pucci, F; Rappazzo, F; Tenerani, A

    2015-05-28

    Coronal heating is at the origin of the EUV and X-ray emission and mass loss from the sun and many other stars. While different scenarios have been proposed to explain the heating of magnetically confined and open regions of the corona, they must all rely on the transfer, storage and dissipation of the abundant energy present in photospheric motions, which, coupled to magnetic fields, give rise to the complex phenomenology seen at the chromosphere and transition region (i.e. spicules, jets, 'tornadoes'). Here we discuss models and numerical simulations which rely on magnetic fields and electric currents both for energy transfer and for storage in the corona. We will revisit the sources and frequency spectrum of kinetic and electromagnetic energies, the role of boundary conditions, and the routes to small scales required for effective dissipation. Because reconnection in current sheets has been, and still is, one of the most important processes for coronal heating, we will also discuss recent aspects concerning the triggering of reconnection instabilities and the transition to fast reconnection. PMID:25897086

  20. Fast-mode elimination in stochastic metapopulation models

    NASA Astrophysics Data System (ADS)

    Constable, George W. A.; McKane, Alan J.

    2014-03-01

    We investigate the stochastic dynamics of entities which are confined to a set of islands, between which they migrate. They are assumed to be one of two types, and in addition to migration, they also reproduce and die. Birth and death events are later moderated by weak selection. Systems which fall into this class are common in biology and social science, occurring in ecology, population genetics, epidemiology, biochemistry, linguistics, opinion dynamics, and other areas. In all these cases the governing equations are intractable, consisting as they do of multidimensional Fokker-Planck equations or, equivalently, coupled nonlinear stochastic differential equations with multiplicative noise. We develop a methodology which exploits a separation in time scales between fast and slow variables to reduce these equations so that they resemble those for a single island, which are amenable to analysis. The technique is generally applicable, but we choose to discuss it in the context of population genetics, in part because of the extra features that appear due to selection. The idea behind the method is simple, its application is systematic, and the results are in very good agreement with simulations of the full model for a range of parameter values.

  1. Spike history neural response model.

    PubMed

    Kameneva, Tatiana; Abramian, Miganoosh; Zarelli, Daniele; Nĕsić, Dragan; Burkitt, Anthony N; Meffin, Hamish; Grayden, David B

    2015-06-01

    There is a potential for improved efficacy of neural stimulation if stimulation levels can be modified dynamically based on the responses of neural tissue in real time. A neural model is developed that describes the response of neurons to electrical stimulation and that is suitable for feedback control neuroprosthetic stimulation. Experimental data from NZ white rabbit retinae is used with a data-driven technique to model neural dynamics. The linear-nonlinear approach is adapted to incorporate spike history and to predict the neural response of ganglion cells to electrical stimulation. To validate the fitness of the model, the penalty term is calculated based on the time difference between each simulated spike and the closest spike in time in the experimentally recorded train. The proposed model is able to robustly predict experimentally observed spike trains.

  2. Modeling rate sensitivity of exercise transient responses to limb motion.

    PubMed

    Yamashiro, Stanley M; Kato, Takahide

    2014-10-01

    Transient responses of ventilation (V̇e) to limb motion can exhibit predictive characteristics. In response to a change in limb motion, a rapid change in V̇e is commonly observed with characteristics different than during a change in workload. This rapid change has been attributed to a feed-forward or adaptive response. Rate sensitivity was explored as a specific hypothesis to explain predictive V̇e responses to limb motion. A simple model assuming an additive feed-forward summation of V̇e proportional to the rate of change of limb motion was studied. This model was able to successfully account for the adaptive phase correction observed during human sinusoidal changes in limb motion. Adaptation of rate sensitivity might also explain the reduction of the fast component of V̇e responses previously reported following sudden exercise termination. Adaptation of the fast component of V̇e response could occur by reduction of rate sensitivity. Rate sensitivity of limb motion was predicted by the model to reduce the phase delay between limb motion and V̇e response without changing the steady-state response to exercise load. In this way, V̇e can respond more quickly to an exercise change without interfering with overall feedback control. The asymmetry between responses to an incremental and decremental ramp change in exercise can also be accounted for by the proposed model. Rate sensitivity leads to predicted behavior, which resembles responses observed in exercise tied to expiratory reserve volume.

  3. On-Orbit Thermal Performance and Model Correlation of the Fast Auroral Snapshot Explorer

    NASA Technical Reports Server (NTRS)

    Parrish, Keith

    1999-01-01

    The Fast Auroral SnapshoT explorer (FAST) spacecraft, the second of NASA's Small Explorer (SMEX) series of scientific satellites, was launched on August 21, 1996 by a Pegasus XL launch vehicle. Due to slightly higher than expected temperatures during early orbit operations, an extensive thermal model correlation effort was undertaken to understand and characterize FAST's thermal performance in order to properly orient the spacecraft's attitude during its mission. FAST's thermal design and the on-orbit thermal model correlation and resolution are described. Finally, the correlated model's predictions are compared with nine months of flight data.

  4. ZnO subwavelength wires for fast-response mid-infrared detection.

    PubMed

    Dai, Wei; Yang, Qing; Gu, Fuxing; Tong, Limin

    2009-11-23

    Room temperature operating thermal detection for mid-infrared light based on ZnO subwavelength wires has been demonstrated. Electric resistance in ZnO wires increases linearly with the intensity of incident light. Noise equivalent power (NEP) of 5.8 microW/Hz(1/2) (at 1 kHz) with typical response times as fast as 1.3 ms is obtained at 10.6-microm wavelength. The sensitivity and response time of the detector are also found to be insensitive to the ambient.

  5. A Transgenic Mouse Model Reveals Fast Nicotinic Transmission in Hippocampal Pyramidal Neurons

    PubMed Central

    Grybko, Michael J.; Hahm, Eu-teum; Perrine, Wesley; Parnes, Jason A.; Chick, Wallace S.; Sharma, Geeta; Finger, Thomas E.; Vijayaraghavan, Sukumar

    2011-01-01

    The relative contribution, to brain cholinergic signaling, by synaptic- and diffusion-based mechanisms remains to be elucidated. In this study, we examined the prevalence of fast nicotinic signaling in the hippocampus. We describe a mouse model where cholinergic axons are labeled with the tauGFP fusion protein driven by the choline acetyltransferase (ChAT) promoter. The model provides for the visualization of individual cholinergic axons at greater resolution than other available models and techniques, even in thick, live, slices. Combining calcium imaging and electrophysiology, we demonstrate that local stimulation of visualized cholinergic fibers results in rapid EPSCs mediated by the activation of α7-subunit containing nicotinic receptors (α7-nAChRs) on CA3 pyramidal neurons. These responses were blocked by the α7-nAChR antagonist methyllycaconitine (MLA) and potentiated by the receptor specific allosteric modulator 1-(5-chloro-2,4- dimethoxy-phenyl)-3-(5-methyl-isoxanol-3-yl)-urea (PNU-120596). Our results suggest, for the first time, that synaptic nAChRs can modulate pyramidal cell plasticity and development. Fast nicotinic transmission might play a greater role in cholinergic signaling than previously assumed. We provide a model for the examination of synaptic properties of basal forebrain cholinergic innervation in the brain. PMID:21501254

  6. Duration of fasting but not diurnal variation affects the response to glucagon in healthy cats.

    PubMed

    Gilor, C; Glock, R; Gilor, S

    2015-10-01

    The role of glucagon disturbances in diabetes is increasingly recognized. Glucagon stimulation tests (GSTs) have been described in cats previously, but information is lacking on the response of cats to glucagon under specific conditions. The aim of this study was to assess a novel protocol for GST using human-recombinant glucagon and the effect of diurnal variation and duration of fasting using this protocol in healthy cats. All intravenous doses resulted in occasional vomiting and nausea, and eventually, a 20-μg/kg intramuscular dose was chosen. Five healthy cats were then used in a repeated-measures study. Cats were free-fed regularly at 7:30 AM and 5:30 PM for 30 min. In each cat, GST was performed at 7 PM after a 25-h fast (PM25), at 9 AM after a 25-h fast (AM25), and at 9 AM after a 15-h fast (AM15). Glucose and insulin concentrations were measured at -15, 0, 15, 25, 35, 45, and 60 min after stimulation. Baseline and peak concentrations were compared using the Friedman test. Baseline glucose and insulin did not differ significantly between treatment groups. Peak glucose concentrations occurred at 15 min and were significantly higher (P = 0.0085) at AM15 (mean ± standard deviation = 185.2 ± 43.0 mg/dL) vs AM25 (144.4 ± 10.5 mg/dL) and PM25 (128.0 ± 18.4 mg/dL). Similarly, peak insulin concentrations occurred at 15 min and were significantly higher (P = 0.04) at AM15 (1,911 ± 1,153 pg/mL) vs AM25 (739 ± 52 pg/mL) or PM25 (549 ± 366 pg/mL). In conclusion, prolonged fasting significantly blunted the glycemic response to glucagon compared with shorter fasting, but diurnal variation had no significant effect on glucose or insulin responses.

  7. Plamsa leptin response to acute fasting and refeeding in untreated women with bulimia nervosa.

    PubMed

    Monteleone, P; Bortolotti, F; Fabrazzo, M; La Rocca, A; Fuschino, A; Maj, M

    2000-07-01

    Leptin is known to regulate body weight, energy balance, and reproduction. Therefore, investigation of its physiology is of obvious interest in bulimia nervosa (BN), an eating disorder characterized by body weight-related psychopathology, acute changes in the energy balance, and reproductive alterations. To date, the few studies that have assessed leptin production in BN have had several limitations, including the measurement of blood leptin levels in treated patients and the lack of normal weight healthy controls, so that the information they provide is not conclusive. As the investigation of leptin dynamics is likely to be more informative, we decided to assess leptin response to acute fasting and refeeding in both untreated patients with BN and healthy controls. Twelve women meeting the diagnostic criteria for BN of the Diagnostic and Statistical Manual of Mental Disorders, and 10 healthy women of the same age range participated in a 3-day study. At 1800 h on day 1, they received a meal of 1088 Cal, with 53% carbohydrates, 17% protein, and 30% fat. Then, they fasted until 1800 h on day 2, when they received the same meal. On day 3, they received a standard hospital diet of 2600 Cal, divided into 3 meals, with the same percentages of nutrients as described above. Blood samples were collected at different time points for plasma leptin, glucose, and insulin measurements. In bulimic patients, plasma leptin values were significantly lower than in healthy women (P < 0.0001) and were positively related to body weight, expressed as body mass index (r = 0.86; P < 0.0001). The leptin response to the fasting/refeeding paradigm significantly differed between patients and controls (time x group interaction, P < 0.0001). In fact, in healthy subjects, acute fasting induced a 58% decline in the plasma leptin concentration, whereas such a decrease was only 7% in bulimic women (P < 0.001). After acute refeeding, plasma leptin increased in both groups, although in the patients it

  8. A new fast reconnection model in a collisionless regime

    SciTech Connect

    Tsiklauri, David

    2008-11-15

    Based on the first principles [i.e., (i) by balancing the magnetic field advection with the term containing electron pressure tensor nongyrotropic components in the generalized Ohm's law; (ii) using the conservation of mass; and (iii) assuming that the weak magnetic field region width, where electron meandering motion supports electron pressure tensor off-diagonal (nongyrotropic) components, is of the order of electron Larmor radius] a simple model of magnetic reconnection in a collisionless regime is formulated. The model is general, resembling its collisional Sweet-Parker analog in that it is not specific to any initial configuration, e.g., Harris-type tearing unstable current sheet, X-point collapse or otherwise. In addition to its importance from the fundamental point of view, the collisionless reconnection model offers a much faster reconnection rate [M{sub c{sup '}}{sub less}=(c/{omega}{sub pe}){sup 2}/(r{sub L,e}L)] than Sweet-Parker's classical one (M{sub sp}=S{sup -1/2}). The width of the diffusion region (current sheet) in the collisionless regime is found to be {delta}{sub c{sup '}}{sub less}=(c/{omega}{sub pe}){sup 2}/r{sub L,e}, which is independent of the global reconnection scale L and is only prescribed by microphysics (electron inertial length, c/{omega}{sub pe}, and electron Larmor radius, r{sub L,e}). Amongst other issues, the fastness of the reconnection rate alleviates, e.g., the problem of interpretation of solar flares by means of reconnection, as for the typical solar coronal parameters the obtained collisionless reconnection time can be a few minutes, as opposed to Sweet-Parker's equivalent value of less than a day. The new theoretical reconnection rate is compared to the Magnetic Reconnection Experiment device experimental data by Yamada et al. [Phys. Plasmas 13, 052119 (2006)] and Ji et al. [Geophys. Res. Lett. 35, 13106 (2008)], and a good agreement is obtained.

  9. Calibration and Validation of a Spar-Type Floating Offshore Wind Turbine Model using the FAST Dynamic Simulation Tool: Preprint

    SciTech Connect

    Browning, J. R.; Jonkman, J.; Robertson, A.; Goupee, A. J.

    2012-11-01

    In 2007, the FAST wind turbine simulation tool, developed and maintained by the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL), was expanded to include capabilities that are suitable for modeling floating offshore wind turbines. In an effort to validate FAST and other offshore wind energy modeling tools, DOE funded the DeepCwind project that tested three prototype floating wind turbines at 1/50th scale in a wave basin, including a semisubmersible, a tension-leg platform, and a spar buoy. This paper describes the use of the results of the spar wave basin tests to calibrate and validate the FAST offshore floating simulation tool, and presents some initial results of simulated dynamic responses of the spar to several combinations of wind and sea states.

  10. 'Bubble chamber model' of fast atom bombardment induced processes.

    PubMed

    Kosevich, Marina V; Shelkovsky, Vadim S; Boryak, Oleg A; Orlov, Vadim V

    2003-01-01

    A hypothesis concerning FAB mechanisms, referred to as a 'bubble chamber FAB model', is proposed. This model can provide an answer to the long-standing question as to how fragile biomolecules and weakly bound clusters can survive under high-energy particle impact on liquids. The basis of this model is a simple estimation of saturated vapour pressure over the surface of liquids, which shows that all liquids ever tested by fast atom bombardment (FAB) and liquid secondary ion mass spectrometry (SIMS) were in the superheated state under the experimental conditions applied. The result of the interaction of the energetic particles with superheated liquids is known to be qualitatively different from that with equilibrium liquids. It consists of initiation of local boiling, i.e., in formation of vapour bubbles along the track of the energetic particle. This phenomenon has been extensively studied in the framework of nuclear physics and provides the basis for construction of the well-known bubble chamber detectors. The possibility of occurrence of similar processes under FAB of superheated liquids substantiates a conceptual model of emission of secondary ions suggested by Vestal in 1983, which assumes formation of bubbles beneath the liquid surface, followed by their bursting accompanied by release of microdroplets and clusters as a necessary intermediate step for the creation of molecular ions. The main distinctive feature of the bubble chamber FAB model, proposed here, is that the bubbles are formed not in the space and time-restricted impact-excited zone, but in the nearby liquid as a 'normal' boiling event, which implies that the temperature both within the bubble and in the droplets emerging on its burst is practically the same as that of the bulk liquid sample. This concept can resolve the paradox of survival of intact biomolecules under FAB, since the part of the sample participating in the liquid-gas transition via the bubble mechanism has an ambient temperature

  11. Modelling hormonal response and development☆

    PubMed Central

    Voß, Ute; Bishopp, Anthony; Farcot, Etienne; Bennett, Malcolm J.

    2014-01-01

    As our knowledge of the complexity of hormone homeostasis, transport, perception, and response increases, and their outputs become less intuitive, modelling is set to become more important. Initial modelling efforts have focused on hormone transport and response pathways. However, we now need to move beyond the network scales and use multicellular and multiscale modelling approaches to predict emergent properties at different scales. Here we review some examples where such approaches have been successful, for example, auxin–cytokinin crosstalk regulating root vascular development or a study of lateral root emergence where an iterative cycle of modelling and experiments lead to the identification of an overlooked role for PIN3. Finally, we discuss some of the remaining biological and technical challenges. PMID:24630843

  12. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.

    PubMed

    Boortz, Kayla A; Syring, Kristen E; Dai, Chunhua; Pound, Lynley D; Oeser, James K; Jacobson, David A; Wang, Jen-Chywan; McGuinness, Owen P; Powers, Alvin C; O'Brien, Richard M

    2016-08-01

    The glucose-6-phosphatase catalytic 2 (G6PC2) gene is expressed specifically in pancreatic islet beta cells. Genome-wide association studies have shown that single nucleotide polymorphisms in the G6PC2 gene are associated with variations in fasting blood glucose (FBG) but not fasting plasma insulin. Molecular analyses examining the functional effects of these single nucleotide polymorphisms demonstrate that elevated G6PC2 expression is associated with elevated FBG. Studies in mice complement these genome-wide association data and show that deletion of the G6pc2 gene lowers FBG without affecting fasting plasma insulin. This suggests that, together with glucokinase, G6PC2 forms a substrate cycle that determines the glucose sensitivity of insulin secretion. Because genome-wide association studies and mouse studies demonstrate that elevated G6PC2 expression raises FBG and because chronically elevated FBG is detrimental to human health, increasing the risk of type 2 diabetes, it is unclear why G6PC2 evolved. We show here that the synthetic glucocorticoid dexamethasone strongly induces human G6PC2 promoter activity and endogenous G6PC2 expression in isolated human islets. Acute treatment with dexamethasone selectively induces endogenous G6pc2 expression in 129SvEv but not C57BL/6J mouse pancreas and isolated islets. The difference is due to a single nucleotide polymorphism in the C57BL/6J G6pc2 promoter that abolishes glucocorticoid receptor binding. In 6-hour fasted, nonstressed 129SvEv mice, deletion of G6pc2 lowers FBG. In response to the stress of repeated physical restraint, which is associated with elevated plasma glucocorticoid levels, G6pc2 gene expression is induced and the difference in FBG between wild-type and knockout mice is enhanced. These data suggest that G6PC2 may have evolved to modulate FBG in response to stress. PMID:27300767

  13. Calibration and validation of a spar-type floating offshore wind turbine model using the FAST dynamic simulation tool

    SciTech Connect

    Browning, J. R.; Jonkman, J.; Robertson, A.; Goupee, A. J.

    2014-01-01

    In this study, high-quality computer simulations are required when designing floating wind turbines because of the complex dynamic responses that are inherent with a high number of degrees of freedom and variable metocean conditions. In 2007, the FAST wind turbine simulation tool, developed and maintained by the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL), was expanded to include capabilities that are suitable for modeling floating offshore wind turbines. In an effort to validate FAST and other offshore wind energy modeling tools, DOE funded the DeepCwind project that tested three prototype floating wind turbines at 1/50th scale in a wave basin, including a semisubmersible, a tension-leg platform, and a spar buoy. This paper describes the use of the results of the spar wave basin tests to calibrate and validate the FAST offshore floating simulation tool, and presents some initial results of simulated dynamic responses of the spar to several combinations of wind and sea states. Wave basin tests with the spar attached to a scale model of the NREL 5-megawatt reference wind turbine were performed at the Maritime Research Institute Netherlands under the DeepCwind project. This project included free-decay tests, tests with steady or turbulent wind and still water (both periodic and irregular waves with no wind), and combined wind/wave tests. The resulting data from the 1/50th model was scaled using Froude scaling to full size and used to calibrate and validate a full-size simulated model in FAST. Results of the model calibration and validation include successes, subtleties, and limitations of both wave basin testing and FAST modeling capabilities.

  14. Calibration and validation of a spar-type floating offshore wind turbine model using the FAST dynamic simulation tool

    NASA Astrophysics Data System (ADS)

    Browning, J. R.; Jonkman, J.; Robertson, A.; Goupee, A. J.

    2014-12-01

    High-quality computer simulations are required when designing floating wind turbines because of the complex dynamic responses that are inherent with a high number of degrees of freedom and variable metocean conditions. In 2007, the FAST wind turbine simulation tool, developed and maintained by the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL), was expanded to include capabilities that are suitable for modeling floating offshore wind turbines. In an effort to validate FAST and other offshore wind energy modeling tools, DOE funded the DeepCwind project that tested three prototype floating wind turbines at 1/50th scale in a wave basin, including a semisubmersible, a tension-leg platform, and a spar buoy. This paper describes the use of the results of the spar wave basin tests to calibrate and validate the FAST offshore floating simulation tool, and presents some initial results of simulated dynamic responses of the spar to several combinations of wind and sea states. Wave basin tests with the spar attached to a scale model of the NREL 5-megawatt reference wind turbine were performed at the Maritime Research Institute Netherlands under the DeepCwind project. This project included free-decay tests, tests with steady or turbulent wind and still water (both periodic and irregular waves with no wind), and combined wind/wave tests. The resulting data from the 1/50th model was scaled using Froude scaling to full size and used to calibrate and validate a full-size simulated model in FAST. Results of the model calibration and validation include successes, subtleties, and limitations of both wave basin testing and FAST modeling capabilities.

  15. Calibration and validation of a spar-type floating offshore wind turbine model using the FAST dynamic simulation tool

    DOE PAGES

    Browning, J. R.; Jonkman, J.; Robertson, A.; Goupee, A. J.

    2014-01-01

    In this study, high-quality computer simulations are required when designing floating wind turbines because of the complex dynamic responses that are inherent with a high number of degrees of freedom and variable metocean conditions. In 2007, the FAST wind turbine simulation tool, developed and maintained by the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL), was expanded to include capabilities that are suitable for modeling floating offshore wind turbines. In an effort to validate FAST and other offshore wind energy modeling tools, DOE funded the DeepCwind project that tested three prototype floating wind turbines at 1/50th scale inmore » a wave basin, including a semisubmersible, a tension-leg platform, and a spar buoy. This paper describes the use of the results of the spar wave basin tests to calibrate and validate the FAST offshore floating simulation tool, and presents some initial results of simulated dynamic responses of the spar to several combinations of wind and sea states. Wave basin tests with the spar attached to a scale model of the NREL 5-megawatt reference wind turbine were performed at the Maritime Research Institute Netherlands under the DeepCwind project. This project included free-decay tests, tests with steady or turbulent wind and still water (both periodic and irregular waves with no wind), and combined wind/wave tests. The resulting data from the 1/50th model was scaled using Froude scaling to full size and used to calibrate and validate a full-size simulated model in FAST. Results of the model calibration and validation include successes, subtleties, and limitations of both wave basin testing and FAST modeling capabilities.« less

  16. A hybrid fast Hankel transform algorithm for electromagnetic modeling

    USGS Publications Warehouse

    Anderson, W.L.

    1989-01-01

    A hybrid fast Hankel transform algorithm has been developed that uses several complementary features of two existing algorithms: Anderson's digital filtering or fast Hankel transform (FHT) algorithm and Chave's quadrature and continued fraction algorithm. A hybrid FHT subprogram (called HYBFHT) written in standard Fortran-77 provides a simple user interface to call either subalgorithm. The hybrid approach is an attempt to combine the best features of the two subalgorithms to minimize the user's coding requirements and to provide fast execution and good accuracy for a large class of electromagnetic problems involving various related Hankel transform sets with multiple arguments. Special cases of Hankel transforms of double-order and double-argument are discussed, where use of HYBFHT is shown to be advantageous for oscillatory kernal functions. -Author

  17. A Measurement Model for Likert Responses that Incorporates Response Time

    ERIC Educational Resources Information Center

    Ferrando, Pere J.; Lorenzo-Seva, Urbano

    2007-01-01

    This article describes a model for response times that is proposed as a supplement to the usual factor-analytic model for responses to graded or more continuous typical-response items. The use of the proposed model together with the factor model provides additional information about the respondent and can potentially increase the accuracy of the…

  18. A TEM-horn antenna with dielectric lens for fast impulse response

    SciTech Connect

    Aurand, J.F.

    1995-12-31

    We designed and constructed a pair of TEM-horn antennas specifically for the very fast time-domain boresight response. Two physical topologies were made. A printed-board configuration has much slower transient response, which we think is due to pulse-smearing of the antenna currents in the dielectric substrate of the printed wiring boards. The solid state version has a 20 ps transition duration response in the main beam endfire (boresight) direction, which is the fastest we have seen to date. And since the antenna has a round trip antenna current propagation time of 6 ns, it offers clean radiated electromagnetic field measurement capability with a clear time of several nanoseconds. The printed board version has resistive loading at the aperture end of the conductors, which should offer better low- frequency performance. The dielectric lens certainly does improve the transient performance of the TEM horn, and was simple to design.

  19. Exupéry - a mobile fast response system for managing a volcanic crisis

    NASA Astrophysics Data System (ADS)

    Hort, M. K.

    2009-12-01

    Despite ever increasing efforts to monitor historically active volcanoes many of those are still very poorly or unmonitored, even in highly populated areas. In case of volcanic unrest or even a volcanic crisis evaluating the situation is therefore often very difficult due to the little information that is available for that specific volcano. Over the past decades several different programs have supported volcanic crisis management efforts in third world countries from sending experts all the way to improving or even installing new networks around the volcano. One of the main problems especially when quickly upgrading networks during a crisis is that each system usually comes with its own acquisition and processing system which makes it very difficult to manage the observational network and provide an interdisciplinary interpretation of the data with respect to the activity status of the volcano. Here we present a newly developed volcano fast response system which overcomes several of these shortcomings. The core of the system is a novel database (SEISHUB) that allows for the collection of data of various kinds, i.e. simple time series data like seismic data, gas measurements, GPS measurements, as well as satellite data (SO2 flux, thermal anomaly, ground deformation). Part of the collected data may also come from an already existing network. Data from new field instruments are transmitted through a wireless network that has been specifically designed for the volcano fast response system. One of the main difficulties with such a multidisciplinary data set is an easy access to the data. This is provided through a common Web based GIS interface which allows various datalayers being simultaneously accessed through a Web Browser. The underlying software is designed in such a way that it only uses open source software, so it can be easily installed on other systems not having to deal with purchasing proprietary software. Aside from this the system provides tools to

  20. Characterizing a fast-response, low-afterglow liquid scintillator for neutron time-of-flight diagnostics in fast ignition experiments.

    PubMed

    Abe, Y; Hosoda, H; Arikawa, Y; Nagai, T; Kojima, S; Sakata, S; Inoue, H; Iwasa, Y; Iwano, K; Yamanoi, K; Fujioka, S; Nakai, M; Sarukura, N; Shiraga, H; Norimatsu, T; Azechi, H

    2014-11-01

    The characteristics of oxygen-enriched liquid scintillators with very low afterglow are investigated and optimized for application to a single-hit neutron spectrometer for fast ignition experiments. It is found that 1,2,4-trimethylbenzene has better characteristics as a liquid scintillator solvent than the conventional solvent, p-xylene. In addition, a benzophenon-doped BBQ liquid scintillator is shown to demonstrate very rapid time response, and therefore has potential for further use in neutron diagnostics with fast time resolution. PMID:25430305

  1. Characterizing a fast-response, low-afterglow liquid scintillator for neutron time-of-flight diagnostics in fast ignition experiments

    SciTech Connect

    Abe, Y. Hosoda, H.; Arikawa, Y.; Nagai, T.; Kojima, S.; Sakata, S.; Inoue, H.; Iwasa, Y.; Iwano, K.; Yamanoi, K.; Fujioka, S.; Nakai, M.; Sarukura, N.; Shiraga, H.; Norimatsu, T.; Azechi, H.

    2014-11-15

    The characteristics of oxygen-enriched liquid scintillators with very low afterglow are investigated and optimized for application to a single-hit neutron spectrometer for fast ignition experiments. It is found that 1,2,4-trimethylbenzene has better characteristics as a liquid scintillator solvent than the conventional solvent, p-xylene. In addition, a benzophenon-doped BBQ liquid scintillator is shown to demonstrate very rapid time response, and therefore has potential for further use in neutron diagnostics with fast time resolution.

  2. Physiological responses to short-term fasting among herbivorous, omnivorous, and carnivorous fishes.

    PubMed

    Day, Ryan D; Tibbetts, Ian R; Secor, Stephen M

    2014-05-01

    We explored the integrated role of dietary specialization and feeding periodicity on the response of the gastrointestinal tract of teleosts fishes to short-term (7-10 days) fasting and refeeding. Fasted and fed herbivorous grass carp (Ctenopharyngodon idella), omnivorous channel catfish (Ictalurus punctatus), and carnivorous largemouth bass (Micropterus salmoides) were compared for digestive organ masses, intestinal morphology, gastrointestinal pH, and the specific activities and total intestinal capacities of the intestinal hydrolases aminopeptidase (APN) and maltase and intestinal nutrient transporters. All three species experience intestinal hypertrophy with feeding as noted by significant increases in enterocyte dimensions. Of the three, only I. punctatus experienced a postprandial increase in intestinal length, and only C. idella experienced significant modulation of intestinal microvillus length. Feeding resulted in acidification of the stomachs of I. punctatus and M. salmoides. Predicted to exhibit a relatively modest set of postprandial responses because of their more frequent feeding habits, C. idella only experienced increases in APN and maltase activity with feeding and no significant regulation of nutrient uptake. Significant regulation of hydrolase activities and nutrient uptake were exhibited by I. punctatus and M. salmoides, with I. punctatus experiencing the most comprehensive set of responses. As predicted by food habits, there was an interspecific gradient in intestinal length and glucose uptake extending from longer intestines and greater glucose uptake for the herbivorous C. idella, intermediate lengths and glucose uptake for the omnivorous I. punctatus, and shorter intestines and reduced glucose uptake for the carnivorous M. salmoides. Among teleosts fishes, short episodes of fasting lead to significant alterations in intestinal form and function that are rapidly restored with feeding. PMID:24604291

  3. Physiological responses to short-term fasting among herbivorous, omnivorous, and carnivorous fishes.

    PubMed

    Day, Ryan D; Tibbetts, Ian R; Secor, Stephen M

    2014-05-01

    We explored the integrated role of dietary specialization and feeding periodicity on the response of the gastrointestinal tract of teleosts fishes to short-term (7-10 days) fasting and refeeding. Fasted and fed herbivorous grass carp (Ctenopharyngodon idella), omnivorous channel catfish (Ictalurus punctatus), and carnivorous largemouth bass (Micropterus salmoides) were compared for digestive organ masses, intestinal morphology, gastrointestinal pH, and the specific activities and total intestinal capacities of the intestinal hydrolases aminopeptidase (APN) and maltase and intestinal nutrient transporters. All three species experience intestinal hypertrophy with feeding as noted by significant increases in enterocyte dimensions. Of the three, only I. punctatus experienced a postprandial increase in intestinal length, and only C. idella experienced significant modulation of intestinal microvillus length. Feeding resulted in acidification of the stomachs of I. punctatus and M. salmoides. Predicted to exhibit a relatively modest set of postprandial responses because of their more frequent feeding habits, C. idella only experienced increases in APN and maltase activity with feeding and no significant regulation of nutrient uptake. Significant regulation of hydrolase activities and nutrient uptake were exhibited by I. punctatus and M. salmoides, with I. punctatus experiencing the most comprehensive set of responses. As predicted by food habits, there was an interspecific gradient in intestinal length and glucose uptake extending from longer intestines and greater glucose uptake for the herbivorous C. idella, intermediate lengths and glucose uptake for the omnivorous I. punctatus, and shorter intestines and reduced glucose uptake for the carnivorous M. salmoides. Among teleosts fishes, short episodes of fasting lead to significant alterations in intestinal form and function that are rapidly restored with feeding.

  4. Fast response temperature and humidity sensors for measurements in high Reynolds number flows

    NASA Astrophysics Data System (ADS)

    Fan, Yuyang; Arwatz, Gilad; Vallikivi, Margit; Hultmark, Marcus

    2013-11-01

    Conventional hot/cold wires have been widely used in measuring velocity and temperature in turbulent flows due to their fine resolutions and fast response. However, for very high Reynolds number flows, limitations on the resolution appear. A very high Reynolds number flow is the atmospheric boundary layer. In order to accurately predict the energy balance at the Earth's surface, one needs information about the different turbulent scalar fields, mainly temperature and humidity, which together with velocity, contribute to the turbulent fluxes away from the surface. The nano-scaled thermal anemometry probe (NSTAP) was previously developed at Princeton and has proven to have much higher spatial and temporal resolution than the regular hot wires. Here we introduce new fast-response temperature and humidity sensors that have been developed and tested. These sensors are made in-house using standard MEMS manufacturing techniques, leaving high flexibility in the process for optimization to different conditions. The small dimensions of these novel sensors enable very high spatial resolution while the small thermal mass allows significant improvements in the frequency response. These sensors have shown promising results in acquiring un-biased data of turbulent scalar and vector fields. Supported under ONR Grants N00014-12-1-0875 and N00014-12-1-0962 (program manager Ki-Han Kim).

  5. Fast response dual-frequency liquid crystal switch with photo-patterned alignments.

    PubMed

    Lin, Xiao-Wen; Hu, Wei; Hu, Xi-Kui; Liang, Xiao; Chen, Ye; Cui, Hong-Qing; Zhu, Ge; Li, Jia-Nan; Chigrinov, Vladimir; Lu, Yan-Qing

    2012-09-01

    A dual-frequency liquid crystal based optical switch with orthogonally photo-patterned alignments is designed and fabricated. The cell gap is theoretically optimized for high switching performance. The measured extinction ratio of first diffraction order is over 20 dB with a low electric field of 3  V/μm. The switch On-Off time are measured to be 350 μs and 600 μs, respectively, both of which have reached submillisecond scale. Moreover, the switch is polarization independent, which has been predicted theoretically and further proved experimentally. This design is suitable in wide applications requiring fast response and polarizer free properties.

  6. Fast and singular muscle responses initiate the startle response of Pantodon buchholzi (Osteoglossomorpha).

    PubMed

    Starosciak, A K; Kalola, R P; Perkins, K P; Riley, J A; Saidel, W M

    2008-01-01

    The startle response of Pantodon buchholzi, the African butterfly fish, is a complete or incomplete ballistic jump resulting from abduction of the pectoral fins. This study analyzed the neuromuscular basis for such a jump by recording in vivo electromyograms (emgs) from the muscles of abduction, the muscularis abductor superficialis (MAS) and the muscularis abductor profundus (MAP). The motor neurons innervating the MAS muscle were localized by retrograde transport of biocytin. The latency between stimulus and the evoked emg in the MAS was less than 5 ms; the latency of the MAP was about 6.5 ms. A single emg was recorded per jump. High speed video demonstrated that onset of a startle movement began within 10 ms of the onset of fin abduction. The emg associated with this movement is short (<2 ms) and followed by a variably-shaped, slower and smaller potential of 10-30 ms duration. The brief period between stimulus and startle response of Pantodon suggests a Mauthner neuron-related response, only with the behavior occurring in the vertical plane. The MAS may act only in a startle response, whereas the MAP might have a role in other behaviors. Elicited jumping habituates after a single trial. Electrophysiological evidence is presented indicating that the innervating motor neurons are suppressed for seconds following a stimulus. The neurons innervating the MAS are located at the medullary-spinal cord junction and possess an average radius of approximately 17.9 mum. These fish have been historically described as 'fresh water' flying fish. As a single emg occurs per startle response, repetitive pectoral activity generating flying cannot be supported. Pantodon 'flight' is ballistic.

  7. Fast and singular muscle responses initiate the startle response of Pantodon buchholzi (Osteoglossomorpha).

    PubMed

    Starosciak, A K; Kalola, R P; Perkins, K P; Riley, J A; Saidel, W M

    2008-01-01

    The startle response of Pantodon buchholzi, the African butterfly fish, is a complete or incomplete ballistic jump resulting from abduction of the pectoral fins. This study analyzed the neuromuscular basis for such a jump by recording in vivo electromyograms (emgs) from the muscles of abduction, the muscularis abductor superficialis (MAS) and the muscularis abductor profundus (MAP). The motor neurons innervating the MAS muscle were localized by retrograde transport of biocytin. The latency between stimulus and the evoked emg in the MAS was less than 5 ms; the latency of the MAP was about 6.5 ms. A single emg was recorded per jump. High speed video demonstrated that onset of a startle movement began within 10 ms of the onset of fin abduction. The emg associated with this movement is short (<2 ms) and followed by a variably-shaped, slower and smaller potential of 10-30 ms duration. The brief period between stimulus and startle response of Pantodon suggests a Mauthner neuron-related response, only with the behavior occurring in the vertical plane. The MAS may act only in a startle response, whereas the MAP might have a role in other behaviors. Elicited jumping habituates after a single trial. Electrophysiological evidence is presented indicating that the innervating motor neurons are suppressed for seconds following a stimulus. The neurons innervating the MAS are located at the medullary-spinal cord junction and possess an average radius of approximately 17.9 mum. These fish have been historically described as 'fresh water' flying fish. As a single emg occurs per startle response, repetitive pectoral activity generating flying cannot be supported. Pantodon 'flight' is ballistic. PMID:18032886

  8. Bifactor Item Response Theory Model of Acute Stress Response

    PubMed Central

    Zhang, Ying; Jiang, Yuan; Tang, Jingjing; Zhu, Xia; Miao, Danmin

    2013-01-01

    Background Better understanding of acute stress responses is important for revision of DSM-5. However, the latent structure and relationship between different aspects of acute stress responses haven’t been clarified comprehensively. Bifactor item response model may help resolve this problem. Objective The purpose of this study is to develop a statistical model of acute stress responses, based on data from earthquake rescuers using Acute Stress Response Scale (ASRS). Through this model, we could better understand acute stress responses comprehensively, and provide preliminary information for computerized adaptive testing of stress responses. Methods Acute stress responses of earthquake rescuers were evaluated using ASRS, and state/trait anxiety were assessed using State-trait Anxiety Inventory (STAI). A hierarchical item response model (bifactor model) was used to analyze the data. Additionally, we tested this hierarchical model with model fit comparisons with one-dimensional and five-dimensional models. The correlations among acute stress responses and state/trait anxiety were compared, based on both the five-dimensional and bifactor models. Results Model fit comparisons showed bifactor model fit the data best. Item loadings on general and specific factors varied greatly between different aspects of stress responses. Many symptoms (40%) of physiological responses had positive loadings on general factor, and negative loadings on specific factor of physiological responses, while other stress responses had positive loadings on both general and specific factors. After extracting general factor of stress responses using bifactor analysis, significant positive correlations between physiological responses and state/trait anxiety (r = 0.185/0.112, p<0.01) changed into negative ones (r = −0.177/−0.38, p<0.01). Conclusion Our results demonstrated bifactor structure of acute stress responses, and positive and negative correlations between physiological responses

  9. Light touch modulates balance recovery following perturbation: from fast response to stance restabilization.

    PubMed

    Martinelli, Alessandra Rezende; Coelho, Daniel Boari; Magalhães, Fernando Henrique; Kohn, André Fabio; Teixeira, Luis Augusto

    2015-05-01

    Light fingertip touch of a static bar generates extra somatosensory information used by the postural control system to reduce body sway. While the effect of light touch has been studied in quiet stance, less attention has been given to its potential benefit for reactive postural responses. In the present study, we tested the effect of light fingertip touch of a stable surface on recovery of postural stability from a mechanical perturbation. Participants stood upright on a force plate touching a static rigid bar while being pulled backward by a load. Unpredictable release of the load induced fast anterior body sway, requiring a reactive response to recover balance. Effect of light touch on postural responses was assessed as a function of vision and malleability of the support surface, analyzing different epochs ranging from the pre-perturbation period to recovery of a relatively stable quiet stance. Results showed that light touch induced lower magnitude of muscular activation in all epochs. Center of pressure (CoP) displacement/sway was affected by interaction of light touch with manipulation of the other sensory information. For the periods associated with quiet stance, light touch led to decreased CoP sway in the malleable surface in the pre-perturbation epoch, and in the condition combining no vision and malleable surface in the balance restabilization and follow-up quiet stance epochs. For the fast reactive response epoch, light touch induced smaller amplitude of CoP displacement across conditions, and lower CoP maximum velocity in the condition combining no vision and rigid surface. These results showed that light touch modulates postural responses in all epochs associated with an unanticipated mechanical perturbation, with a more noticeable effect in conditions manipulating sensory information relevant for balance control.

  10. Problems in modeling TF ripple loss of fast alphas from a tokamak reactor

    SciTech Connect

    Hively, L.M.

    1987-01-01

    The present status of modeling TF ripple loss of fast alphas from tokamaks is summarized. The modeling issues are discussed, and several new aspects of this problem are described, including gyromotion, radial electric field, and sawtoothing. Existing models predict that TF ripple loss of fast alphas will have a low-to-moderate impact on the design of a tokamak engineering test reactor (ETR). 52 refs., 3 figs., 2 tabs.

  11. Fast-response humidity-sensing films based on methylene blue aggregates formed on nanoporous semiconductor films

    NASA Astrophysics Data System (ADS)

    Ishizaki, Ryota; Katoh, Ryuzi

    2016-05-01

    We prepared fast-response colorimetric humidity-sensing (vapochromic) films based on methylene blue adsorption onto nanoporous semiconductor (TiO2, Al2O3) films. Color changes caused by changes of humidity could be easily identified visually. A characteristic feature of the vapochromic films was their fast response to changes of humidity. We found that the response began to occur within 10 ms. The response was rapid because all the methylene blue molecules attached to the nanoporous semiconductor surface were directly exposed to the environment. We also deduced that the color changes were caused by structural changes of the methylene blue aggregates on the surface.

  12. Fast quasi-explicit finite difference simulation of electrochemical responses initiated by a discontinuous perturbation

    SciTech Connect

    Feldberg, S.W.

    1991-01-01

    Commencing in the early 60s the application of explicit finite difference (EFD) methods to the analysis of electrochemical problems paralleled the development and availability of fast, main-frame, digital computers. The appeal of the EFD method has been its simplicity of principle and of application. EFD algorithms, however, are notoriously inefficient for solving certain types of stiff problems (e.g., problems involving a wide dynamic range of time constants). In this presentation the author discusses the principles and some applications of a fast quasi-explicit finite difference (FQEFD) method in which the computational speed is enhanced, by many orders of magnitude in some cases, without compromising the user friendliness which has popularized the EFD method. The method is designed to treat electrochemical responses to a discontinuous (e.g, chronoamperometric) perturbation and utilizes the DuFort-Frankel algorithm (1) with exponentially expanding space (2) and exponentially expanding time grids. (A previously published version of the FQEFD method (3,4) was designed to treat electrochemical responses to a continuous (e.g., cyclic voltammetric) perturbation and utilizes the DuFort-Frankel (3) algorithm in conjunction with an exponentially expanding space grid and a uniform time grid. The development of the basic FQEFD equations was presented there). The protocol for introducing the expanding time grid is straightforward and is discussed. 7 refs., 1 fig. 1 tab.

  13. A Mixed Effects Randomized Item Response Model

    ERIC Educational Resources Information Center

    Fox, J.-P.; Wyrick, Cheryl

    2008-01-01

    The randomized response technique ensures that individual item responses, denoted as true item responses, are randomized before observing them and so-called randomized item responses are observed. A relationship is specified between randomized item response data and true item response data. True item response data are modeled with a (non)linear…

  14. Thermal remote sensing as a part of Exupéry volcano fast response system

    NASA Astrophysics Data System (ADS)

    Zakšek, Klemen; Hort, Matthias

    2010-05-01

    In order to understand the eruptive potential of a volcanic system one has to characterize the actual state of stress of a volcanic system that involves proper monitoring strategies. As several volcanoes in highly populated areas especially in south east Asia are still nearly unmonitored a mobile volcano monitoring system is currently being developed in Germany. One of the major novelties of this mobile volcano fast response system called Exupéry is the direct inclusion of satellite based observations. Remote sensing data are introduced together with ground based field measurements into the GIS database, where the statistical properties of all recorded data are estimated. Using physical modelling and statistical methods we hope to constrain the probability of future eruptions. The emphasis of this contribution is on using thermal remote sensing as tool for monitoring active volcanoes. One can detect thermal anomalies originating from a volcano by comparing signals in mid and thermal infrared spectra. A reliable and effective thermal anomalies detection algorithm was developed by Wright (2002) for MODIS sensor; it is based on the threshold of the so called normalized thermal index (NTI). This is the method we use in Exupéry, where we characterize each detected thermal anomaly by temperature, area, heat flux and effusion rate. The recent work has shown that radiant flux is the most robust parameter for this characterization. Its derivation depends on atmosphere, satellite viewing angle and sensor characteristics. Some of these influences are easy to correct using standard remote sensing pre-processing techniques, however, some noise still remains in data. In addition, satellites in polar orbits have long revisit times and thus they might fail to follow a fast evolving volcanic crisis due to long revisit times. Thus we are currently testing Kalman filter on simultaneous use of MODIS and AVHRR data to improve the thermal anomaly characterization. The advantage of

  15. Static and transient modeling of fast moving ball actuator as a display device

    NASA Astrophysics Data System (ADS)

    Lee, Jongmo; Yoon, Ho Won; Hong, MunPyo; Jhun, Chul Gyu; Bae, Byung Seong; Han, Seungoh

    2016-04-01

    FMBA(Fast Moving Ball Actuator), developed as novel electronic-paper display, has already proven its operability and functionality. However, optimization issues related with low operating voltage, high refresh rate, fine pixel and higher display resolution, etc. are still remaining to be improved for a successful commercialization. In order to optimize such issues effectively, static and transient model were developed and verified by comparing the calculated results to the measured. The static model is based on the force balancing equation between the driving and the holding forces while the transient model is developed from Newton's 2nd law by adding the inertia as well as the resistive damping forces caused by the surroundings. With the simplified static model, driving voltage of 30.71 V was obtained, which is reasonably matched to the measured voltage of 40 V. Based on the transient model, also, the transient response of the device can be estimated within reasonable margin. Considering the absence of reliable key parameters of surface roughness, static and dynamic frictional coefficient, and refractive indices, the developed static and transient models account well the experimental results and thus they are expected to contribute further improvements in FMBA.

  16. A dynamic prescribed vortex wake model for the FAST/AeroDyn wind energy conversion simulation code

    NASA Astrophysics Data System (ADS)

    Currin, Hugh D.

    2007-12-01

    A Dynamic Prescribed Vortex Wake model for analysis of horizontal axis wind turbines has been developed. This model extends the HAWTDAWG steady state prescribed wake code to dynamic flows. This extension assumes wake vortices follow prescription functions valid at the time each vortex is generated. This allows modeling of dynamic wake effects known to exist. This assumption is supported through analysis and comparison to UAE Phase VI test data. The new Dynamic Prescribed Vortex Wake model is built into AeroDyn as a third aerodynamic model and uses the FAST structural dynamic model. It implements the wind models and dynamic stall model in AeroDyn. FAST structural degrees of freedom are implemented. Comparisons are made to UAE Phase VI wind tunnel data, and to the other two AeroDyn models, Blade Element Momentum and Generalized Dynamic Wake. Both steady, to verify the base model, and dynamic, to validate the extension to dynamic flow, conditions are considered. Both axial and yawed flow are analyzed. Dynamic UAE test data analyzed include rapid pitch, Sequence Q, and yaw release, Sequence E. The Dynamic Prescribed Wake model compares favorably to test data and to other AeroDyn models. Small rapid dynamic response is noted in each model and the test data. The new Dynamic Prescribed Vortex Wake model shows promise. Release of the code for experimental use and further validation is recommended.

  17. Fast-coding robust motion estimation model in a GPU

    NASA Astrophysics Data System (ADS)

    García, Carlos; Botella, Guillermo; de Sande, Francisco; Prieto-Matias, Manuel

    2015-02-01

    Nowadays vision systems are used with countless purposes. Moreover, the motion estimation is a discipline that allow to extract relevant information as pattern segmentation, 3D structure or tracking objects. However, the real-time requirements in most applications has limited its consolidation, considering the adoption of high performance systems to meet response times. With the emergence of so-called highly parallel devices known as accelerators this gap has narrowed. Two extreme endpoints in the spectrum of most common accelerators are Field Programmable Gate Array (FPGA) and Graphics Processing Systems (GPU), which usually offer higher performance rates than general propose processors. Moreover, the use of GPUs as accelerators involves the efficient exploitation of any parallelism in the target application. This task is not easy because performance rates are affected by many aspects that programmers should overcome. In this paper, we evaluate OpenACC standard, a programming model with directives which favors porting any code to a GPU in the context of motion estimation application. The results confirm that this programming paradigm is suitable for this image processing applications achieving a very satisfactory acceleration in convolution based problems as in the well-known Lucas & Kanade method.

  18. Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting.

    PubMed

    Stengel, Andreas; Goebel, Miriam; Million, Mulugeta; Stenzel-Poore, Mary P; Kobelt, Peter; Mönnikes, Hubert; Taché, Yvette; Wang, Lixin

    2009-01-01

    Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulating ghrelin levels, and gastric emptying of a nonnutrient meal. CRF-OE mice injected ip with saline showed a 47 and 44% reduction of 30-min and 4-h cumulative food intake response to an overnight fast, respectively, compared with WT. However, the 30-min food intake decrease induced by ip cholecystokinin (3 microg/kg) and increase by ghrelin (300 microg/kg) were similar in CRF-OE and WT mice. Overnight fasting increased the plasma total ghrelin to similar levels in CRF-OE and WT mice, although CRF-OE mice had a 2-fold reduction of nonfasting ghrelin levels. The number of Fos-immunoreactive cells induced by fasting in the arcuate nucleus was reduced by 5.9-fold in CRF-OE compared with WT mice whereas no significant changes were observed in other hypothalamic nuclei. In contrast, fasted CRF-OE mice displayed a 5.6-fold increase in Fos-immunoreactive cell number in the dorsal motor nucleus of the vagus nerve and a 34% increase in 20-min gastric emptying. These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response.

  19. GPU-based ultra-fast dose calculation using a finite size pencil beam model

    NASA Astrophysics Data System (ADS)

    Gu, Xuejun; Choi, Dongju; Men, Chunhua; Pan, Hubert; Majumdar, Amitava; Jiang, Steve B.

    2009-10-01

    Online adaptive radiation therapy (ART) is an attractive concept that promises the ability to deliver an optimal treatment in response to the inter-fraction variability in patient anatomy. However, it has yet to be realized due to technical limitations. Fast dose deposit coefficient calculation is a critical component of the online planning process that is required for plan optimization of intensity-modulated radiation therapy (IMRT). Computer graphics processing units (GPUs) are well suited to provide the requisite fast performance for the data-parallel nature of dose calculation. In this work, we develop a dose calculation engine based on a finite-size pencil beam (FSPB) algorithm and a GPU parallel computing framework. The developed framework can accommodate any FSPB model. We test our implementation in the case of a water phantom and the case of a prostate cancer patient with varying beamlet and voxel sizes. All testing scenarios achieved speedup ranging from 200 to 400 times when using a NVIDIA Tesla C1060 card in comparison with a 2.27 GHz Intel Xeon CPU. The computational time for calculating dose deposition coefficients for a nine-field prostate IMRT plan with this new framework is less than 1 s. This indicates that the GPU-based FSPB algorithm is well suited for online re-planning for adaptive radiotherapy.

  20. Mesoscale Simulation Data for Initializing Fast-Time Wake Transport and Decay Models

    NASA Technical Reports Server (NTRS)

    Ahmad, Nashat N.; Proctor, Fred H.; Vanvalkenburg, Randal L.; Pruis, Mathew J.; LimonDuparcmeur, Fanny M.

    2012-01-01

    The fast-time wake transport and decay models require vertical profiles of crosswinds, potential temperature and the eddy dissipation rate as initial conditions. These inputs are normally obtained from various field sensors. In case of data-denied scenarios or operational use, these initial conditions can be provided by mesoscale model simulations. In this study, the vertical profiles of potential temperature from a mesoscale model were used as initial conditions for the fast-time wake models. The mesoscale model simulations were compared against available observations and the wake model predictions were compared with the Lidar measurements from three wake vortex field experiments.

  1. Fast Model Generalized Pseudopotential Theory (MGPT) Interatomic Potential Routine

    2015-03-18

    MGPT is an unclassified source code for the fast evaluation and application of quantum-based MGPT interatomic potentials for mrtals. The present version of MGPT has been developed entirely at LLNL, but is specifically designed for implementation in the open-source molecular0dynamics code LAMMPS maintained by Sandia National Laboratories. Using MGPT in LAMMPS, with separate input potential data, one can perform large-scale atomistic simulations of the structural, thermodynamic, defeat and mechanical properties of transition metals with quantum-mechanicalmore » realism.« less

  2. Fast Model Generalized Pseudopotential Theory (MGPT) Interatomic Potential Routine

    SciTech Connect

    2015-03-18

    MGPT is an unclassified source code for the fast evaluation and application of quantum-based MGPT interatomic potentials for mrtals. The present version of MGPT has been developed entirely at LLNL, but is specifically designed for implementation in the open-source molecular0dynamics code LAMMPS maintained by Sandia National Laboratories. Using MGPT in LAMMPS, with separate input potential data, one can perform large-scale atomistic simulations of the structural, thermodynamic, defeat and mechanical properties of transition metals with quantum-mechanical realism.

  3. Changes in metabolism in response to fasting and food restriction in the Steller sea lion (Eumetopias jubatus).

    PubMed

    Rosen, David A S; Trites, Andrew W

    2002-06-01

    Many animals lower their resting metabolism (metabolic depression) when fasting or consuming inadequate food. We sought to document this response by subjecting five Steller sea lions to periods of: (1) complete fasting; or (2) restricting them to 50% of their normal herring diet. The sea lions lost an average of 1.5% of their initial body mass per day (2.30 kg/d) during the 9-14-day fast, and their resting metabolic rates decreased 31%, which is typical of a "fasting response". However, metabolic depression did not occur during the 28-day food restriction trials, despite the loss of 0.30% of body mass per day (0.42 kg/d). This difference in response suggests that undernutrition caused by reduced food intake may stimulate a "hunger response", which in turn might lead to increased foraging effort. The progressive changes in metabolism we observed during the fasts were related to, but were not directly caused by, changes in body mass from control levels. Combining these results with data collected from experiments when Steller sea lions were losing mass on low energy squid and pollock diets reveals a strong relationship between relative changes in body mass and relative changes in resting metabolism across experimental conditions. While metabolic depression caused by fasting or consuming large amounts of low energy food reduced the direct costs from resting metabolism, it was insufficient to completely overcome the incurred energy deficit. PMID:12031465

  4. Fast-response IR spatial light modulators with a polymer network liquid crystal

    NASA Astrophysics Data System (ADS)

    Peng, Fenglin; Chen, Haiwei; Tripathi, Suvagata; Twieg, Robert J.; Wu, Shin-Tson

    2015-03-01

    Liquid crystals (LC) have widespread applications for amplitude modulation (e.g. flat panel displays) and phase modulation (e.g. beam steering). For phase modulation, a 2π phase modulo is required. To extend the electro-optic application into infrared region (MWIR and LWIR), several key technical challenges have to be overcome: 1. low absorption loss, 2. high birefringence, 3. low operation voltage, and 4. fast response time. After three decades of extensive development, an increasing number of IR devices adopting LC technology have been demonstrated, such as liquid crystal waveguide, laser beam steering at 1.55μm and 10.6 μm, spatial light modulator in the MWIR (3~5μm) band, dynamic scene projectors for infrared seekers in the LWIR (8~12μm) band. However, several fundamental molecular vibration bands and overtones exist in the MWIR and LWIR regions, which contribute to high absorption coefficient and hinder its widespread application. Therefore, the inherent absorption loss becomes a major concern for IR devices. To suppress IR absorption, several approaches have been investigated: 1) Employing thin cell gap by choosing a high birefringence liquid crystal mixture; 2) Shifting the absorption bands outside the spectral region of interest by deuteration, fluorination and chlorination; 3) Reducing the overlap vibration bands by using shorter alkyl chain compounds. In this paper, we report some chlorinated LC compounds and mixtures with a low absorption loss in the near infrared and MWIR regions. To achieve fast response time, we have demonstrated a polymer network liquid crystal with 2π phase change at MWIR and response time less than 5 ms.

  5. Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

    PubMed

    Wang, Qiao-Ping; Lin, Yong Qi; Zhang, Lei; Wilson, Yana A; Oyston, Lisa J; Cotterell, James; Qi, Yue; Khuong, Thang M; Bakhshi, Noman; Planchenault, Yoann; Browman, Duncan T; Lau, Man Tat; Cole, Tiffany A; Wong, Adam C N; Simpson, Stephen J; Cole, Adam R; Penninger, Josef M; Herzog, Herbert; Neely, G Gregory

    2016-07-12

    Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together, our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat. PMID:27411010

  6. ATGL and HSL are not coordinately regulated in response to fuel partitioning in fasted rats.

    PubMed

    Bertile, Fabrice; Raclot, Thierry

    2011-04-01

    Prolonged fasting is characterized by lipid mobilization (Phase 2), followed by protein breakdown (Phase 3). Knowing that body lipids are not exhausted in Phase 3, we investigated whether changes in the metabolic status of prolonged fasted rats are associated with differences in the expression of epididymal adipose tissue proteins involved in lipid mobilization. The final body mass, body lipid content, locomotor activity and metabolite and hormone plasma levels differed between groups. Compared with fed rats, adiposity and epididymal fat mass decreased in Phase 2 (approximately two- to threefold) and Phase 3 (∼4.5-14-fold). Plasma nonesterified fatty acids (NEFA) concentrations were increased in Phase 2 (approximately twofold) and decreased in Phase 3 (approximately twofold). Daily locomotor activity was markedly increased in Phase 3 (∼11-fold). Compared with the fed state, expressions of adipose triglyceride lipase (ATGL; mRNA and protein), hormone-sensitive lipase (HSL; mRNA) and phosphorylated HSL at residue Ser660 (HSL Ser(660)) were increased during Phase 2 (∼1.5-2-fold). HSL (mRNA and protein) and HSL Ser(660) levels were lowered during Phase 3 (∼3-12-fold). Unlike HSL and HSL Ser(660), ATGL expression did not correlate with circulating NEFA, mostly due to data from animals in Phase 3. At this stage, ATGL could play an essential role for maintaining a low mobilization rate of NEFA, possibly to sustain muscle performance and hence increased locomotor activity. We conclude that ATGL and HSL are not coordinately regulated in response to changes in fuel partitioning during prolonged food deprivation, ATGL appearing as the major lipase in late fasting.

  7. Modeling of traveling compression regions in the Earth's magnetotail by the spontaneous fast reconnection model

    SciTech Connect

    Ugai, M.; Zheng, L.

    2006-03-15

    The spontaneous fast reconnection model is applied to the traveling compression regions (TCRs) observed in the Earth's magnetotail lobe region in association with substorms. For this purpose, virtual satellites are located at spatial points in the (low-{beta}) magnetic field region in the three-dimenisonal simulation domain, so that each satellite directly observes the temporal variations of magnetic fields, obtained from simulations, in accordance with the growth and proceeding of the fast reconnection mechanism. If the virtual satellite is located ahead of the initial plasmoid formation, it observes a pulse-like field compression with the compression rate of more than 10% as well as the bipolar structure of the magnetic field component from northward to southward tilting, when the plasmoid center passes through the satellite location. On the other hand, if it is located behind the plasmoid formation, it observes the unipolar structure of the southward field component. The simulation results are shown to be, both quantitatively and qualitatively, in good agreement with the actual satellite observations. It is demonstrated that the TCR event is the fast reconnection mechanism itself that is seen in the ambient (low-{beta}) magnetic field (magnetotail lobe) region.

  8. Fast response of electron-scale turbulence to auxiliary heating cessation in National Spherical Torus Experiment

    SciTech Connect

    Ren, Y.; Wang, W. X.; LeBlanc, B. P.; Guttenfelder, W.; Kaye, S. M.; Ethier, S.; Mazzucato, E.; Bell, R.; Lee, K. C.; Domier, C. W.; Smith, D. R.; Yuh, H.

    2015-11-15

    In this letter, we report the first observation of the fast response of electron-scale turbulence to auxiliary heating cessation in National Spherical Torus eXperiment [Ono et al., Nucl. Fusion 40, 557 (2000)]. The observation was made in a set of RF-heated L-mode plasmas with toroidal magnetic field of 0.55 T and plasma current of 300 kA. It is observed that electron-scale turbulence spectral power (measured with a high-k collective microwave scattering system) decreases significantly following fast cessation of RF heating that occurs in less than 200 μs. The large drop in the turbulence spectral power has a short time delay of about 1–2 ms relative to the RF cessation and happens on a time scale of 0.5–1 ms, much smaller than the energy confinement time of about 10 ms. Power balance analysis shows a factor of about 2 decrease in electron thermal diffusivity after the sudden drop of turbulence spectral power. Measured small changes in equilibrium profiles across the RF cessation are unlikely able to explain this sudden reduction in the measured turbulence and decrease in electron thermal transport, supported by local linear stability analysis and both local and global nonlinear gyrokinetic simulations. The observations imply that nonlocal flux-driven mechanism may be important for the observed turbulence and electron thermal transport.

  9. Fast response of electron-scale turbulence to auxiliary heating cessation in National Spherical Torus Experiment

    SciTech Connect

    Ren, Y.; Wang, W. X.; LeBlanc, B. P.; Guttenfelder, W.; Kaye, S. M.; Ethier, S.; Mazzucato, E.; Lee, K. C.; Domier, C. W.; Bell, R.; Smith, D. R.; Yuh, H.

    2015-11-03

    In this letter, we report the first observation of the fast response of electron-scale turbulence to auxiliary heating cessation in National Spherical Torus eXperiment [Ono et al., Nucl. Fusion 40, 557 (2000)]. The observation was made in a set of RF-heated L-mode plasmas with toroidal magnetic field of 0.55 T and plasma current of 300 kA. It is observed that electron-scale turbulence spectral power (measured with a high-k collective microwave scattering system) decreases significantly following fast cessation of RF heating that occurs in less than 200 μs. The large drop in the turbulence spectral power has a short time delay of about 1–2 ms relative to the RF cessation and happens on a time scale of 0.5–1 ms, much smaller than the energy confinement time of about 10 ms. Power balance analysis shows a factor of about 2 decrease in electron thermal diffusivity after the sudden drop of turbulence spectral power. Measured small changes in equilibrium profiles across the RF cessation are unlikely able to explain this sudden reduction in the measured turbulence and decrease in electron thermal transport, supported by local linear stability analysis and both local and global nonlinear gyrokinetic simulations. Furthermore, the observations imply that nonlocal flux-driven mechanism may be important for the observed turbulence and electron thermal transport.

  10. Fast response of electron-scale turbulence to auxiliary heating cessation in National Spherical Torus Experiment

    DOE PAGES

    Ren, Y.; Wang, W. X.; LeBlanc, B. P.; Guttenfelder, W.; Kaye, S. M.; Ethier, S.; Mazzucato, E.; Lee, K. C.; Domier, C. W.; Bell, R.; et al

    2015-11-03

    In this letter, we report the first observation of the fast response of electron-scale turbulence to auxiliary heating cessation in National Spherical Torus eXperiment [Ono et al., Nucl. Fusion 40, 557 (2000)]. The observation was made in a set of RF-heated L-mode plasmas with toroidal magnetic field of 0.55 T and plasma current of 300 kA. It is observed that electron-scale turbulence spectral power (measured with a high-k collective microwave scattering system) decreases significantly following fast cessation of RF heating that occurs in less than 200 μs. The large drop in the turbulence spectral power has a short time delaymore » of about 1–2 ms relative to the RF cessation and happens on a time scale of 0.5–1 ms, much smaller than the energy confinement time of about 10 ms. Power balance analysis shows a factor of about 2 decrease in electron thermal diffusivity after the sudden drop of turbulence spectral power. Measured small changes in equilibrium profiles across the RF cessation are unlikely able to explain this sudden reduction in the measured turbulence and decrease in electron thermal transport, supported by local linear stability analysis and both local and global nonlinear gyrokinetic simulations. Furthermore, the observations imply that nonlocal flux-driven mechanism may be important for the observed turbulence and electron thermal transport.« less

  11. Renal responses to plasma volume expansion and hyperosmolality in fasting seal pups

    NASA Technical Reports Server (NTRS)

    Ortiz, Rudy M.; Wade, Charles E.; Costa, Daniel P.; Ortiz, C. Leo

    2002-01-01

    Renal responses were quantified in northern elephant seal (Mirounga angustirostris) pups during their postweaning fast to examine their excretory capabilities. Pups were infused with either isotonic (0.9%; n = 8; Iso) or hypertonic (16.7%; n = 7; Hyper) saline via an indwelling catheter such that each pup received 3 mmol NaCl/kg. Diuresis after the infusions was similar in magnitude between the two treatments. Osmotic clearance increased by 37% in Iso and 252% in Hyper. Free water clearance was reduced 3.4-fold in Hyper but was not significantly altered in Iso. Glomerular filtration rate increased 71% in the 24-h period after Hyper, but no net change occurred during the same time after Iso. Natriuresis increased 3.6-fold in Iso and 5.3-fold in Hyper. Iso decreased plasma arginine vasopressin (AVP) and cortisol acutely, whereas Hyper increased plasma and excreted AVP and cortisol. Iso was accompanied by the retention of water and electrolytes, whereas the Hyper load was excreted within 24 h. Natriuresis is attributed to increased filtration and is independent of an increase in atrial natriuretic peptide and decreases in ANG II and aldosterone. Fasting pups appear to have well-developed kidneys capable of both extreme conservation and excretion of Na(+).

  12. A flap-type hydrogel actuator with fast responses to temperature

    NASA Astrophysics Data System (ADS)

    Zhang, Yaopeng; Kato, Shinji; Anazawa, Takanori

    2007-12-01

    A novel temperature-sensitive hydrogel with fast deswelling and swelling rates was prepared from an N-isopropylacrylamide monomer mixture with poly(vinylpyrrolidone) (PVP) and its lightly crosslinked counterpart (so-called polyvinyl-polypyrrolidone, PVPP). The PVP worked as a porogen for the polymerization-induced phase separation of the hydrogel while the PVPP microgels were used as a pore-structure modifier. The hydrogel, in the form of a layer, was laminated with an acrylic resin layer to make a temperature-sensitive flap which can work as a bimetallic-like actuator with fast responses. Owing to the different deswelling/swelling ratios of the two layers, the smart flap bent in opposite directions in water at different temperatures. The switching temperature, at which the flap changed its bending direction, was adjusted by applying different ratios of PVP/PVPP in the hydrogel precursors. Dynamic results show that the flap with a hydrogel layer modified by PVP/PVPP required only several seconds to bend to its equilibrium states in both directions. No obvious performance loss was found after numerous heating-cooling cycles and the processes of drying and recovery.

  13. Unique and shared responses of the gut microbiota to prolonged fasting: a comparative study across five classes of vertebrate hosts.

    PubMed

    Kohl, Kevin D; Amaya, James; Passement, Celeste A; Dearing, M Denise; McCue, Marshall D

    2014-12-01

    Many animals face unpredictable food sources and periods of prolonged fasting, which likely present significant challenges to gut microorganisms. While several studies have demonstrated that fasting impacts the gut microbiota, experiments have not been carried out in a comparative context. We used 16S rRNA gene sequencing to document changes in colonic and cecal microbiomes of animals representing five classes of vertebrates at four time points through prolonged fasting: tilapia, toads, geckos, quail, and mice. We found differences in the starvation-induced changes in the microbiome across host species and across gut regions. Microbial phylogenetic diversity increased as a result of fasting in the colons of fish, toads, and mice, while quail exhibited a decrease in diversity; geckos exhibited no change. Microbial diversity in the cecum decreased in fish and exhibited no change in mice. Alterations in relative abundances of microbial taxa varied across hosts. Fish exhibited the most significant changes due to fasting, while geckos maintained a stable community over 28 days of fasting. We uncovered several shared responses of the microbiota across hosts. For example, all tetrapods exhibited decreases in the abundances of Coprobacillus and Ruminococcus in response to fasting. We also discuss host-mediated physiological mechanisms that may underlie these community changes.

  14. Unique and shared responses of the gut microbiota to prolonged fasting: a comparative study across five classes of vertebrate hosts.

    PubMed

    Kohl, Kevin D; Amaya, James; Passement, Celeste A; Dearing, M Denise; McCue, Marshall D

    2014-12-01

    Many animals face unpredictable food sources and periods of prolonged fasting, which likely present significant challenges to gut microorganisms. While several studies have demonstrated that fasting impacts the gut microbiota, experiments have not been carried out in a comparative context. We used 16S rRNA gene sequencing to document changes in colonic and cecal microbiomes of animals representing five classes of vertebrates at four time points through prolonged fasting: tilapia, toads, geckos, quail, and mice. We found differences in the starvation-induced changes in the microbiome across host species and across gut regions. Microbial phylogenetic diversity increased as a result of fasting in the colons of fish, toads, and mice, while quail exhibited a decrease in diversity; geckos exhibited no change. Microbial diversity in the cecum decreased in fish and exhibited no change in mice. Alterations in relative abundances of microbial taxa varied across hosts. Fish exhibited the most significant changes due to fasting, while geckos maintained a stable community over 28 days of fasting. We uncovered several shared responses of the microbiota across hosts. For example, all tetrapods exhibited decreases in the abundances of Coprobacillus and Ruminococcus in response to fasting. We also discuss host-mediated physiological mechanisms that may underlie these community changes. PMID:25319042

  15. Impedance changes recorded with scalp electrodes during visual evoked responses: implications for Electrical Impedance Tomography of fast neural activity.

    PubMed

    Gilad, O; Holder, D S

    2009-08-15

    Electrical Impedance Tomography (EIT) is a recently developed medical imaging method which could enable fast neural imaging in the brain by recording the resistance changes which occur as ion channels open during neuronal depolarization. In published studies in animal models with intracranial electrodes, changes of 0.005 to 3% have been reported but the amplitude of changes in the human is not known. The purpose of this work was to determine if resistance changes could be recorded non-invasively in humans during evoked activity which could form the basis for EIT of fast neural activity. Resistance was recorded with scalp electrodes during 2 Hz pattern visual evoked responses over 10 min using an insensible 1 Hz square wave constant current of 0.1-1 mA. Significant resistance decreases of 0.0010+/-0.0005% (0.30+/-0.15 microV, signal-to-noise ratio (SNR) of 2:1, n=16 recordings over 6 subjects) (mean+/-SE) were recorded. These are in broad agreement with modelling which estimated changes of 0.0039+/-0.0034% (1.03+/-0.75 microV) using an anatomically realistic finite element model. This is the first demonstration of such changes in humans and so encourages the belief that EIT could be used for neural imaging. Unfortunately, the signal-to-noise ratio was not sufficient to permit imaging at present because recording over multiple injection sites needed for imaging would require impractically long recording times. However, in the future, invasive imaging with intracranial electrodes in animal models or humans and improved signal processing or recording may still enable imaging; this would constitute a significant advance in neuroscience technology.

  16. Model reduction for slow–fast stochastic systems with metastable behaviour

    SciTech Connect

    Bruna, Maria; Chapman, S. Jonathan; Smith, Matthew J.

    2014-05-07

    The quasi-steady-state approximation (or stochastic averaging principle) is a useful tool in the study of multiscale stochastic systems, giving a practical method by which to reduce the number of degrees of freedom in a model. The method is extended here to slow–fast systems in which the fast variables exhibit metastable behaviour. The key parameter that determines the form of the reduced model is the ratio of the timescale for the switching of the fast variables between metastable states to the timescale for the evolution of the slow variables. The method is illustrated with two examples: one from biochemistry (a fast-species-mediated chemical switch coupled to a slower varying species), and one from ecology (a predator–prey system). Numerical simulations of each model reduction are compared with those of the full system.

  17. Potentiation of Hormonal Responses to Hemorrhage and Fasting, but not Hypoglycemia in Conscious Adrenalectomized Rats

    NASA Technical Reports Server (NTRS)

    Darlington, Daniel N.; Keil, Lanny C.; Dallman, Mary F.

    1989-01-01

    Bilateral adrenalectomy (ADRX) in rats removes the source of two major stress-responsive hormones, corticosterone and epinephrine. To test how ADRX rats with-stand stress, we performed the following experiments in adult male rats provided with indwelling femoral arterial and venous cannulae and either ADRX or sham-adrenalectomized (Sham) 3 days later and given 0.5% NaCl to drink. Five to 6 days after adrenal surgery the rats were studied after either a 15 ml/kg.5 min hemorrhage or after an overnight fast followed by insulin-induced hypoglycemia. In fed unstressed ADRX rats, basal mean arterial blood pressure was slightly decreased; heart rate was increased; blood volume, vasopressin, and oxytocin concentrations were not different from sham values; and renin and norepinephrine were significantly elevated. The recovery of arterial pressure after hemorrhage in the ADRX rats was similar to that in the sham group over a 5-h period; however, the responses of vasopressin and oxytocin were significantly greater, and those of renin and norepinephrine were markedly potentiated in the ADRX group. Heart rate recovered faster in the ADRX group and was elevated, compared to the sham value, for most of the 5-h period. Restitution of blood volume was attenuated in the ADRX group, although the restitution of plasma protein was not different between the groups. A significant difference in the change in plasma osmolality between groups after hemorrhage may account for the attenuated restitution of blood volume. After an overnight fast, which reduced blood volume in both groups of rats, the plasma renin concentration rose still further in ADRX rats; the differences in other measured variables observed between fed ADRX and sham groups remained the same. The insulin-induced 50% decrease in glucose caused minor effects on arterial blood pressure and heart rate and occasioned responses in renin and norepinephrine of similar magnitudes in the two groups. We conclude that in the absence of

  18. Fast response neutron emission monitor for fusion reactor using stilbene scintillator and Flash-ADC.

    PubMed

    Itoga, T; Ishikawa, M; Baba, M; Okuji, T; Oishi, T; Nakhostin, M; Nishitani, T

    2007-01-01

    The stilbene neutron detector which has been used for neutron emission profile monitoring in JT-60U has been improved, to respond to the requirement to observe the high-frequency phenomena in megahertz region such as toroidicity-induced Alfvén Eigen mode in burning plasma as well as the spatial profile and the energy spectrum. This high-frequency phenomenon is of great interest and one of the key issues in plasma physics in recent years. To achieve a fast response in the stilbene detector, a Flash-ADC is applied and the wave form of the anode signal stored directly, and neutron/gamma discrimination was carried out via software with a new scheme for data acquisition mode to extend the count rate limit to MHz region from 1.3 x 10(5) neutron/s in the past, and confirmed the adequacy of the method.

  19. A new fast response instrument for measuring total water content from aircraft

    NASA Astrophysics Data System (ADS)

    Nicholls, S.; Leighton, J.; Barker, R.

    1990-10-01

    A device for measuring the total water content of a parcel of air from an aircraft has been developed. The total water of a parcel of air is a conserved quantity, independent of phase changes, provided there is no transport of water through the parcel boundaries. Current airborne hygrometers normally attempt to measure the water content in individual phases and the presence of other phases invariably influences the quality of the data. However, any liquid water or ice entering this new probe is efficiently evaporated and the resultant water vapor measured using a Lyman-alpha hygrometer. In airborne trials the device was calibrated against a cooled-mirror dewpoint device. Runs were conducted in warm stratocumulus tops, through small cumulus, in mixed-phase precipitation and cirrus cloud. In all cases the device was found to produce high quality, fast response data.

  20. Simulation of response functions of fast neutron sensors and development of thin neutron silicon sensor.

    PubMed

    Takada, Masashi; Nakamura, Takashi; Matsuda, Mikihiko; Nunomiya, Tomoya

    2014-10-01

    On radiation detection using silicon sensor, signals are produced from collected charges in a depletion layer; however, for high-energy particles, this depletion layer is extended due to funnelling phenomenon. The lengths of charge collection were experimentally obtained from proton peak energies in measured pulse-heights. The length is extended with increasing proton energy of up to 6 MeV, and then, is constant over 6 MeV. The response functions of fast neutron sensors were simulated for 5- and 15-MeV monoenergetic and (252)Cf neutron sources using the Monte Carlo N-Particle eXtended code. The simulation results agree well with the experimental ones, including the effect of funnelling phenomenon. In addition, a thin silicon sensor was developed for a new real-time personal neutron dosemeter. Photon sensitivity is vanishingly smaller than neutron one by a factor of 5×10(-4). PMID:24516186

  1. Fast response dual-frequency liquid crystal switch with photo-patterned alignments.

    PubMed

    Lin, Xiao-Wen; Hu, Wei; Hu, Xi-Kui; Liang, Xiao; Chen, Ye; Cui, Hong-Qing; Zhu, Ge; Li, Jia-Nan; Chigrinov, Vladimir; Lu, Yan-Qing

    2012-09-01

    A dual-frequency liquid crystal based optical switch with orthogonally photo-patterned alignments is designed and fabricated. The cell gap is theoretically optimized for high switching performance. The measured extinction ratio of first diffraction order is over 20 dB with a low electric field of 3  V/μm. The switch On-Off time are measured to be 350 μs and 600 μs, respectively, both of which have reached submillisecond scale. Moreover, the switch is polarization independent, which has been predicted theoretically and further proved experimentally. This design is suitable in wide applications requiring fast response and polarizer free properties. PMID:22940971

  2. Simulation of response functions of fast neutron sensors and development of thin neutron silicon sensor.

    PubMed

    Takada, Masashi; Nakamura, Takashi; Matsuda, Mikihiko; Nunomiya, Tomoya

    2014-10-01

    On radiation detection using silicon sensor, signals are produced from collected charges in a depletion layer; however, for high-energy particles, this depletion layer is extended due to funnelling phenomenon. The lengths of charge collection were experimentally obtained from proton peak energies in measured pulse-heights. The length is extended with increasing proton energy of up to 6 MeV, and then, is constant over 6 MeV. The response functions of fast neutron sensors were simulated for 5- and 15-MeV monoenergetic and (252)Cf neutron sources using the Monte Carlo N-Particle eXtended code. The simulation results agree well with the experimental ones, including the effect of funnelling phenomenon. In addition, a thin silicon sensor was developed for a new real-time personal neutron dosemeter. Photon sensitivity is vanishingly smaller than neutron one by a factor of 5×10(-4).

  3. Simulating polar bear energetics during a seasonal fast using a mechanistic model.

    PubMed

    Mathewson, Paul D; Porter, Warren P

    2013-01-01

    In this study we tested the ability of a mechanistic model (Niche Mapper™) to accurately model adult, non-denning polar bear (Ursus maritimus) energetics while fasting during the ice-free season in the western Hudson Bay. The model uses a steady state heat balance approach, which calculates the metabolic rate that will allow an animal to maintain its core temperature in its particular microclimate conditions. Predicted weight loss for a 120 day fast typical of the 1990s was comparable to empirical studies of the population, and the model was able to reach a heat balance at the target metabolic rate for the entire fast, supporting use of the model to explore the impacts of climate change on polar bears. Niche Mapper predicted that all but the poorest condition bears would survive a 120 day fast under current climate conditions. When the fast extended to 180 days, Niche Mapper predicted mortality of up to 18% for males. Our results illustrate how environmental conditions, variation in animal properties, and thermoregulation processes may impact survival during extended fasts because polar bears were predicted to require additional energetic expenditure for thermoregulation during a 180 day fast. A uniform 3°C temperature increase reduced male mortality during a 180 day fast from 18% to 15%. Niche Mapper explicitly links an animal's energetics to environmental conditions and thus can be a valuable tool to help inform predictions of climate-related population changes. Since Niche Mapper is a generic model, it can make energetic predictions for other species threatened by climate change.

  4. Fast surface alignment for cardiac spatio-temporal modeling: application to Ischemic cardiac shape modeling

    NASA Astrophysics Data System (ADS)

    Huang, Heng; Shen, Li; Zhang, Rong; Makedon, Fillia; Hettleman, Bruce; Pearlman, Justin

    2006-03-01

    The visualization and comparison of local deformation from 3D image sequences is of critical importance in understanding the etiology of Ischemic cardiac disease. In this paper we describe a framework to combine our previous fast spherical harmonic surface alignment algorithm with a new local special surface reconstruction method to reconstruct the surface of LV with Ischaemic cardiac disease. Our new surface computational model allows people to extract the valuable ischemic tissues behavior from the dynamic shape. We have demonstrated our approaches by the experiments on cardiac MRI. A brief description of motivation is put forth, as well as an overview of the approaches and some initial results are described.

  5. Fast Responsive and Controllable Liquid Transport on a Magnetic Fluid/Nanoarray Composite Interface.

    PubMed

    Tian, Dongliang; Zhang, Na; Zheng, Xi; Hou, Guanglei; Tian, Ye; Du, Yi; Jiang, Lei; Dou, Shi Xue

    2016-06-28

    Controllable liquid transport on surface is expected to occur by manipulating the gradient of surface tension/Laplace pressure and external stimuli, which has been intensively studied on solid or liquid interface. However, it still faces challenges of slow response rate, and uncontrollable transport speed and direction. Here, we demonstrate fast responsive and controllable liquid transport on a smart magnetic fluid/nanoarray interface, i.e., a composite interface, via modulation of an external magnetic field. The wettability of the composite interface to water instantaneously responds to gradient magnetic field due to the magnetically driven composite interface gradient roughness transition that takes place within a millisecond, which is at least 1 order of magnitude faster than that of other responsive surfaces. A water droplet can follow the motion of the gradient composite interface structure as it responds to the gradient magnetic field motion. Moreover, the water droplet transport direction can be controlled by modulating the motion direction of the gradient magnetic field. The composite interface can be used as a pump for the transport of immiscible liquids and other objects in the microchannel, which suggests a way to design smart interface materials and microfluidic devices. PMID:27199104

  6. Jobs and Economic Development Impact (JEDI) User Reference Guide: Fast Pyrolysis Biorefinery Model

    SciTech Connect

    Zhang, Y.; Goldberg, M.

    2015-02-01

    This guide -- the JEDI Fast Pyrolysis Biorefinery Model User Reference Guide -- was developed to assist users in operating and understanding the JEDI Fast Pyrolysis Biorefinery Model. The guide provides information on the model's underlying methodology, as well as the parameters and data sources used to develop the cost data utilized in the model. This guide also provides basic instruction on model add-in features and a discussion of how the results should be interpreted. Based on project-specific inputs from the user, the JEDI Fast Pyrolysis Biorefinery Model estimates local (e.g., county- or state-level) job creation, earnings, and output from total economic activity for a given fast pyrolysis biorefinery. These estimates include the direct, indirect and induced economic impacts to the local economy associated with the construction and operation phases of biorefinery projects.Local revenue and supply chain impacts as well as induced impacts are estimated using economic multipliers derived from the IMPLAN software program. By determining the local economic impacts and job creation for a proposed biorefinery, the JEDI Fast Pyrolysis Biorefinery Model can be used to field questions about the added value biorefineries might bring to a local community.

  7. Response of slow and fast muscle to hypothyroidism: maximal shortening velocity and myosin isoforms

    NASA Technical Reports Server (NTRS)

    Caiozzo, V. J.; Herrick, R. E.; Baldwin, K. M.

    1992-01-01

    This study examined both the shortening velocity and myosin isoform distribution of slow- (soleus) and fast-twitch (plantaris) skeletal muscles under hypothyroid conditions. Adult female Sprague-Dawley rats were randomly assigned to one of two groups: control (n = 7) or hypothyroid (n = 7). In both muscles, the relative contents of native slow myosin (SM) and type I myosin heavy chain (MHC) increased in response to the hypothyroid treatment. The effects were such that the hypothyroid soleus muscle expressed only the native SM and type I MHC isoforms while repressing native intermediate myosin and type IIA MHC. In the plantaris, the relative content of native SM and type I MHC isoforms increased from 5 to 13% and from 4 to 10% of the total myosin pool, respectively. Maximal shortening velocity of the soleus and plantaris as measured by the slack test decreased by 32 and 19%, respectively, in response to hypothyroidism. In contrast, maximal shortening velocity as estimated by force-velocity data decreased only in the soleus (-19%). No significant change was observed for the plantaris.

  8. Breaking cover: neural responses to slow and fast camouflage-breaking motion

    PubMed Central

    Yin, Jiapeng; Gong, Hongliang; An, Xu; Chen, Zheyuan; Lu, Yiliang; Andolina, Ian M.; McLoughlin, Niall; Wang, Wei

    2015-01-01

    Primates need to detect and recognize camouflaged animals in natural environments. Camouflage-breaking movements are often the only visual cue available to accomplish this. Specifically, sudden movements are often detected before full recognition of the camouflaged animal is made, suggesting that initial processing of motion precedes the recognition of motion-defined contours or shapes. What are the neuronal mechanisms underlying this initial processing of camouflaged motion in the primate visual brain? We investigated this question using intrinsic-signal optical imaging of macaque V1, V2 and V4, along with computer simulations of the neural population responses. We found that camouflaged motion at low speed was processed as a direction signal by both direction- and orientation-selective neurons, whereas at high-speed camouflaged motion was encoded as a motion-streak signal primarily by orientation-selective neurons. No population responses were found to be invariant to the camouflage contours. These results suggest that the initial processing of camouflaged motion at low and high speeds is encoded as direction and motion-streak signals in primate early visual cortices. These processes are consistent with a spatio-temporal filter mechanism that provides for fast processing of motion signals, prior to full recognition of camouflage-breaking animals. PMID:26269500

  9. Homology modeling a fast tool for drug discovery: current perspectives.

    PubMed

    Vyas, V K; Ukawala, R D; Ghate, M; Chintha, C

    2012-01-01

    Major goal of structural biology involve formation of protein-ligand complexes; in which the protein molecules act energetically in the course of binding. Therefore, perceptive of protein-ligand interaction will be very important for structure based drug design. Lack of knowledge of 3D structures has hindered efforts to understand the binding specificities of ligands with protein. With increasing in modeling software and the growing number of known protein structures, homology modeling is rapidly becoming the method of choice for obtaining 3D coordinates of proteins. Homology modeling is a representation of the similarity of environmental residues at topologically corresponding positions in the reference proteins. In the absence of experimental data, model building on the basis of a known 3D structure of a homologous protein is at present the only reliable method to obtain the structural information. Knowledge of the 3D structures of proteins provides invaluable insights into the molecular basis of their functions. The recent advances in homology modeling, particularly in detecting and aligning sequences with template structures, distant homologues, modeling of loops and side chains as well as detecting errors in a model contributed to consistent prediction of protein structure, which was not possible even several years ago. This review focused on the features and a role of homology modeling in predicting protein structure and described current developments in this field with victorious applications at the different stages of the drug design and discovery.

  10. Neural dynamics in a model of the thalamocortical system. I. Layers, loops and the emergence of fast synchronous rhythms.

    PubMed

    Lumer, E D; Edelman, G M; Tononi, G

    1997-01-01

    A large-scale computer model was constructed to gain insight into the structural basis for the generation of fast synchronous rhythms (20-60 Hz) in the thalamocortical system. The model consisted of 65,000 spiking neurons organized topographically to represent sectors of a primary and secondary area of mammalian visual cortex, and two associated regions of the dorsal thalamus and the thalamic reticular nucleus. Cortical neurons, both excitatory and inhibitory, were organized in supragranular layers, infraganular layers and layer IV. Reciprocal intra- and interlaminar, interareal, thalamocortical, corticothalamic and thalamoreticular connections were set up based on known anatomical constraints. Simulations of neuronal responses to visual input revealed sporadic epochs of synchronous oscillations involving all levels of the model, similar to the fast rhythms recorded in vivo. By systematically modifying physiological and structural parameters in the model, specific network properties were found to play a major role in the generation of this rhythmic activity. For example, fast synchronous rhythms could be sustained autonomously by lateral and interlaminar interactions within and among local cortical circuits. In addition, these oscillations were propagated to the thalamus and amplified by corticothalamocortical loops, including the thalamic reticular complex. Finally, synchronous oscillations were differentially affected by lesioning forward and backward interareal connections.

  11. Case-based reasoning(CBR) model for ultra-fast cooling in plate mill

    NASA Astrophysics Data System (ADS)

    Hu, Xiao; Wang, Zhaodong; Wang, Guodong

    2014-11-01

    New generation thermo-mechanical control process(TMCP) based on ultra-fast cooling is being widely adopted in plate mill to product high-performance steel material at low cost. Ultra-fast cooling system is complex because of optimizing the temperature control error generated by heat transfer mathematical model and process parameters. In order to simplify the system and improve the temperature control precision in ultra-fast cooling process, several existing models of case-based reasoning(CBR) model are reviewed. Combining with ultra-fast cooling process, a developed R5 CBR model is proposed, which mainly improves the case representation, similarity relation and retrieval module. Certainty factor is defined in semantics memory unit of plate case which provides not only internal data reliability but also product performance reliability. Similarity relation is improved by defined power index similarity membership function. Retrieval process is simplified and retrieval efficiency is improved apparently by windmill retrieval algorithm. The proposed CBR model is used for predicting the case of cooling strategy and its capability is superior to traditional process model. In order to perform comprehensive investigations on ultra-fast cooling process, different steel plates are considered for the experiment. The validation experiment and industrial production of proposed CBR model are carried out, which demonstrated that finish cooling temperature(FCT) error is controlled within ±25°C and quality rate of product is more than 97%. The proposed CBR model can simplify ultra-fast cooling system and give quality performance for steel product.

  12. The development of a fast radiative transfer model based on an empirical orthogonal functions (EOF) technique

    NASA Astrophysics Data System (ADS)

    Havemann, Stephan

    2006-12-01

    Remote sensing with the new generation of highly spectrally resolving instruments like the Atmospheric Research Interferometer Evaluation System (ARIES) or the assimilation of highly resolved spectra from satellites into Numerical Weather Prediction (NWP) systems requires radiative transfer computations that deliver results essentially instantaneous. This paper reports on the development of such a new fast radiative transfer model. The model is based on an Empirical Orthogonal Functions (EOF) technique. The model can be used for the simulation of sensors with different characteristics and in different spectral ranges from the solar to the infrared. For the purpose of airborne remote sensing, the fast model has been designed to work on any altitude and for slant paths whilst looking down or up. The fast model works for situations with diverse temperature and humidity profiles to an accuracy of better than 0.01K for most of the instrument channels. The EOF fast model works for clear-sky atmospheres and is applicable to atmospheres with scattering layers of aerosols or clouds. The fast model is trained with a large set of diverse atmospheric training profiles. In forward calculations corresponding high resolution spectra are obtained. An EOF analysis is performed on these spectra and only the leading EOF are retained (data compression). When the fast model is applied to a new independent profile, only the weights of the EOF need to be calculated (=predicted). Monochromatic radiances at suitable frequencies are used as predictors. The frequency selection is done by a cluster algorithm, which sorts frequencies with similar characteristics into clusters.

  13. Fokker-Planck model for collisional loss of fast ions in tokamaks

    NASA Astrophysics Data System (ADS)

    Yavorskij, V.; Goloborod'ko, V.; Schoepf, K.

    2016-11-01

    Modelling of the collisional loss of fast ions from tokamak plasmas is important from the point of view of the impact of fusion alphas and neutral beam injection ions on plasma facing components as well as for the development of diagnostics of fast ion losses [1-3]. This paper develops a Fokker-Planck (FP) method for the assessment of distributions of collisional loss of fast ions as depending on the coordinates of the first wall surface and on the velocities of lost ions. It is shown that the complete 4D drift FP approach for description of fast ions in axisymmetric tokamak plasmas can be reduced to a 2D FP problem for lost ions with a boundary condition delivered by the solution of a 3D boundary value problem for confined ions. Based on this newly developed FP approach the poloidal distribution of neoclassical loss, depending on pitch-angle and energy, of fast ions from tokamak plasma may be examined as well as the contribution of this loss to the signal detected by the scintillator probe may be evaluated. It is pointed out that the loss distributions obtained with the novel FP treatment may serve as an alternative approach with respect to Monte-Carlo models [4, 5] commonly used for simulating fast ion loss from toroidal plasmas.

  14. Advanced model for fast assessment of piezoelectric micro energy harvesters

    NASA Astrophysics Data System (ADS)

    Ardito, Raffaele; Corigliano, Alberto; Gafforelli, Giacomo; Valzasina, Carlo; Procopio, Francesco; Zafalon, Roberto

    2016-04-01

    The purpose of this work is to present recent advances in modelling and design of piezoelectric energy harvesters, in the framework of Micro-Electro-Mechanical Systems (MEMS). More specifically, the case of inertial energy harvesting is considered, in the sense that the kinetic energy due to environmental vibration is transformed into electrical energy by means of piezoelectric transduction. The execution of numerical analyses is greatly important in order to predict the actual behaviour of MEMS devices and to carry out the optimization process. In the common practice, the results are obtained by means of burdensome 3D Finite Element Analyses (FEA). The case of beams could be treated by applying 1D models, which can enormously reduce the computational burden with obvious benefits in the case of repeated analyses. Unfortunately, the presence of piezoelectric coupling may entail some serious issues in view of its intrinsically three-dimensional behaviour. In this paper, a refined, yet simple, model is proposed with the objective of retaining the Euler-Bernoulli beam model, with the inclusion of effects connected to the actual three-dimensional shape of the device. The proposed model is adopted to evaluate the performances of realistic harvesters, both in the case of harmonic excitation and for impulsive loads.

  15. Response characteristics of a low-dimensional model neuron.

    PubMed

    Cartling, B

    1996-11-15

    It is shown that a low-dimensional model neuron with a response time constant smaller than the membrane time constant closely reproduces the activity and excitability behavior of a detailed conductance-based model of Hodgkin-Huxley type. The fast response of the activity variable also makes it possible to reduce the model to a one-dimensional model, in particular for typical conditions. As an example, the reduction to a single-variable model from a multivariable conductance-based model of a neocortical pyramidal cell with somatic input is demonstrated. The conditions for avoiding a spurious damped oscillatory response to a constant input are derived, and it is shown that a limit-cycle response cannot occur. The capability of the low-dimensional model to approximate higher-dimensional models accurately makes it useful for describing complex dynamics of nets of interconnected neurons. The simplicity of the model facilitates analytic studies, elucidations of neurocomputational mechanisms, and applications to large-scale systems.

  16. TRANC - a novel fast-response converter to measure total reactive atmospheric nitrogen

    NASA Astrophysics Data System (ADS)

    Marx, O.; Brümmer, C.; Ammann, C.; Wolff, V.; Freibauer, A.

    2011-12-01

    The input and loss of plant available nitrogen (N) from/to the atmosphere can be an important factor for the productivity of ecosystems and thus for its carbon and greenhouse gas exchange. We present a novel converter for the measurement of total reactive nitrogen (TRANC: Total Reactive Atmospheric Nitrogen Converter), which offers the opportunity to quantify the sum of all airborne reactive nitrogen (Nr) compounds in high time resolution. The basic concept of the TRANC is the full conversion of total Nr to nitrogen monoxide (NO) within two reaction steps. Initially, reduced N compounds are being oxidised, and oxidised N compounds are thermally converted to lower oxidation states. Particulate N is being sublimated and oxidised or reduced afterwards. In a second step, remaining higher N oxides or those originated in the first step are catalytically converted to NO with carbon monoxide used as reduction gas. The converter is combined with a fast response chemiluminescence detector (CLD) for NO analysis and its performance was tested for the most relevant gaseous and particulate Nr species under both laboratory and field conditions. Recovery rates during laboratory tests for NH3 and NO2 were found to be 95 and 99%, respectively, and 97% when the two gases were combined. In-field longterm stability over an 11-month period was approved by a value of 91% for NO2. Effective conversion was also found for ammonium and nitrate containing particles. The recovery rate of total ambient Nr was tested against the sum of individual measurements of NH3, HNO3, HONO, NH4+, NO3-, and NOx using a combination of different well-established devices. The results show that the TRANC-CLD system precisely captures fluctuations in Nr concentrations and also matches the sum of all Nr compounds measured by the different single techniques. The TRANC features a specific design with very short distance between the sample air inlet and the place where the thermal and catalytic conversions to NO

  17. TRANC - a novel fast-response converter to measure total reactive atmospheric nitrogen

    NASA Astrophysics Data System (ADS)

    Marx, O.; Brümmer, C.; Ammann, C.; Wolff, V.; Freibauer, A.

    2012-05-01

    The input and loss of plant available nitrogen (reactive nitrogen: Nr) from/to the atmosphere can be an important factor for the productivity of ecosystems and thus for its carbon and greenhouse gas exchange. We present a novel converter for reactive nitrogen (TRANC: Total Reactive Atmospheric Nitrogen Converter), which offers the opportunity to quantify the sum of all airborne reactive nitrogen compounds (∑Nr) in high time resolution. The basic concept of the TRANC is the full conversion of all Nr to nitrogen monoxide (NO) within two reaction steps. Initially, reduced Nr compounds are being oxidised, and oxidised Nr compounds are thermally converted to lower oxidation states. Particulate Nr is being sublimated and oxidised or reduced afterwards. In a second step, remaining higher nitrogen oxides or those generated in the first step are catalytically converted to NO with carbon monoxide used as reduction gas. The converter is combined with a fast response chemiluminescence detector (CLD) for NO analysis and its performance was tested for the most relevant gaseous and particulate Nr species under both laboratory and field conditions. Recovery rates during laboratory tests for NH3 and NO2 were found to be 95 and 99%, respectively, and 97% when the two gases were combined. In-field longterm stability over an 11-month period was approved by a value of 91% for NO2. Effective conversion was also found for ammonium and nitrate containing particles. The recovery rate of total ambient Nr was tested against the sum of individual measurements of NH3, HNO3, HONO, NH4+, NO3-, and NOx using a combination of different well-established devices. The results show that the TRANC-CLD system precisely captures fluctuations in ∑Nr concentrations and also matches the sum of all individual Nr compounds measured by the different single techniques. The TRANC features a specific design with very short distance between the sample air inlet and the place where the thermal and catalytic

  18. Kinetic models for historical processes of fast invasion and aggression

    NASA Astrophysics Data System (ADS)

    Aristov, Vladimir V.; Ilyin, Oleg V.

    2015-04-01

    In the last few decades many investigations have been devoted to theoretical models in new areas concerning description of different biological, sociological, and historical processes. In the present paper we suggest a model of the Nazi Germany invasion of Poland, France, and the USSR based on kinetic theory. We simulate this process with the Cauchy boundary problem for two-element kinetic equations. The solution of the problem is given in the form of a traveling wave. The propagation velocity of a front line depends on the quotient between initial forces concentrations. Moreover it is obtained that the general solution of the model can be expressed in terms of quadratures and elementary functions. Finally it is shown that the front-line velocities agree with the historical data.

  19. Sampling frequency, response times and embedded signal filtration in fast, high efficiency liquid chromatography: A tutorial.

    PubMed

    Wahab, M Farooq; Dasgupta, Purnendu K; Kadjo, Akinde F; Armstrong, Daniel W

    2016-02-11

    With increasingly efficient columns, eluite peaks are increasingly narrower. To take full advantage of this, choice of the detector response time and the data acquisition rate a.k.a. detector sampling frequency, have become increasingly important. In this work, we revisit the concept of data sampling from the theorem variously attributed to Whittaker, Nyquist, Kotelnikov, and Shannon. Focusing on time scales relevant to the current practice of high performance liquid chromatography (HPLC) and optical absorbance detection (the most commonly used method), even for very narrow simulated peaks Fourier transformation shows that theoretical minimum sampling frequency is still relatively low (<10 Hz). However, this consideration alone may not be adequate for real chromatograms when an appreciable amount of noise is present. Further, depending on the instrument, the manufacturer's choice of a particular data bunching/integration/response time condition may be integrally coupled to the sampling frequency. In any case, the exact nature of signal filtration often occurs in a manner neither transparent to nor controllable by the user. Using fast chromatography on a state-of-the-art column (38,000 plates), we evaluate the responses produced by different present generation instruments, each with their unique black box digital filters. We show that the common wisdom of sampling 20 points per peak can be inadequate for high efficiency columns and that the sampling frequency and response choices do affect the peak shape. If the sampling frequency is too low or response time is too large, the observed peak shapes will not remain as narrow as they really are - this is especially true for high efficiency and high speed separations. It is shown that both sampling frequency and digital filtering affect the retention time, noise amplitude, peak shape and width in a complex fashion. We show how a square-wave driven light emitting diode source can reveal the nature of the embedded filter

  20. Sampling frequency, response times and embedded signal filtration in fast, high efficiency liquid chromatography: A tutorial.

    PubMed

    Wahab, M Farooq; Dasgupta, Purnendu K; Kadjo, Akinde F; Armstrong, Daniel W

    2016-02-11

    With increasingly efficient columns, eluite peaks are increasingly narrower. To take full advantage of this, choice of the detector response time and the data acquisition rate a.k.a. detector sampling frequency, have become increasingly important. In this work, we revisit the concept of data sampling from the theorem variously attributed to Whittaker, Nyquist, Kotelnikov, and Shannon. Focusing on time scales relevant to the current practice of high performance liquid chromatography (HPLC) and optical absorbance detection (the most commonly used method), even for very narrow simulated peaks Fourier transformation shows that theoretical minimum sampling frequency is still relatively low (<10 Hz). However, this consideration alone may not be adequate for real chromatograms when an appreciable amount of noise is present. Further, depending on the instrument, the manufacturer's choice of a particular data bunching/integration/response time condition may be integrally coupled to the sampling frequency. In any case, the exact nature of signal filtration often occurs in a manner neither transparent to nor controllable by the user. Using fast chromatography on a state-of-the-art column (38,000 plates), we evaluate the responses produced by different present generation instruments, each with their unique black box digital filters. We show that the common wisdom of sampling 20 points per peak can be inadequate for high efficiency columns and that the sampling frequency and response choices do affect the peak shape. If the sampling frequency is too low or response time is too large, the observed peak shapes will not remain as narrow as they really are - this is especially true for high efficiency and high speed separations. It is shown that both sampling frequency and digital filtering affect the retention time, noise amplitude, peak shape and width in a complex fashion. We show how a square-wave driven light emitting diode source can reveal the nature of the embedded filter

  1. Evaluation of Fast-Time Wake Vortex Models using Wake Encounter Flight Test Data

    NASA Technical Reports Server (NTRS)

    Ahmad, Nashat N.; VanValkenburg, Randal L.; Bowles, Roland L.; Limon Duparcmeur, Fanny M.; Gloudesman, Thijs; van Lochem, Sander; Ras, Eelco

    2014-01-01

    This paper describes a methodology for the integration and evaluation of fast-time wake models with flight data. The National Aeronautics and Space Administration conducted detailed flight tests in 1995 and 1997 under the Aircraft Vortex Spacing System Program to characterize wake vortex decay and wake encounter dynamics. In this study, data collected during Flight 705 were used to evaluate NASA's fast-time wake transport and decay models. Deterministic and Monte-Carlo simulations were conducted to define wake hazard bounds behind the wake generator. The methodology described in this paper can be used for further validation of fast-time wake models using en-route flight data, and for determining wake turbulence constraints in the design of air traffic management concepts.

  2. Fast and Accurate Circuit Design Automation through Hierarchical Model Switching.

    PubMed

    Huynh, Linh; Tagkopoulos, Ilias

    2015-08-21

    In computer-aided biological design, the trifecta of characterized part libraries, accurate models and optimal design parameters is crucial for producing reliable designs. As the number of parts and model complexity increase, however, it becomes exponentially more difficult for any optimization method to search the solution space, hence creating a trade-off that hampers efficient design. To address this issue, we present a hierarchical computer-aided design architecture that uses a two-step approach for biological design. First, a simple model of low computational complexity is used to predict circuit behavior and assess candidate circuit branches through branch-and-bound methods. Then, a complex, nonlinear circuit model is used for a fine-grained search of the reduced solution space, thus achieving more accurate results. Evaluation with a benchmark of 11 circuits and a library of 102 experimental designs with known characterization parameters demonstrates a speed-up of 3 orders of magnitude when compared to other design methods that provide optimality guarantees.

  3. Teaching about Heterogeneous Response Models

    ERIC Educational Resources Information Center

    Murray, Michael P.

    2014-01-01

    Individuals vary in their responses to incentives and opportunities. For example, additional education will affect one person differently than another. In recent years, econometricians have given increased attention to such heterogeneous responses and to the consequences of such responses for interpreting regression estimates, especially…

  4. Fast Ray Tracing of Lunar Digital Elevation Models

    NASA Technical Reports Server (NTRS)

    McClanahan, Timothy P.; Evans, L. G.; Starr, R. D.; Mitrofanov, I.

    2009-01-01

    Ray-tracing (RT) of Lunar Digital Elevation Models (DEM)'s is performed to virtually derive the degree of radiation incident to terrain as a function of time, orbital and ephemeris constraints [I- 4]. This process is an integral modeling process in lunar polar research and exploration due to the present paucity of terrain information at the poles and mission planning activities for the anticipated spring 2009 launch of the Lunar Reconnaissance Orbiter (LRO). As part of the Lunar Exploration Neutron Detector (LEND) and Lunar Crater Observation and Sensing Satellite (LCROSS) preparations RI methods are used to estimate the critical conditions presented by the combined effects of high latitude, terrain and the moons low obliquity [5-7]. These factors yield low incident solar illumination and subsequently extreme thermal, and radiation conditions. The presented research uses RT methods both for radiation transport modeling in space and regolith related research as well as to derive permanently shadowed regions (PSR)'s in high latitude topographic minima, e.g craters. These regions are of scientific and human exploration interest due to the near constant low temperatures in PSRs, inferred to be < 100 K. Hydrogen is thought to have accumulated in PSR's through the combined effects of periodic cometary bombardment and/or solar wind processes, and the extreme cold which minimizes hydrogen sublimation [8-9]. RT methods are also of use in surface position optimization for future illumination dependent on surface resources e.g. power and communications equipment.

  5. Fast neural network surrogates for very high dimensional physics-based models in computational oceanography.

    PubMed

    van der Merwe, Rudolph; Leen, Todd K; Lu, Zhengdong; Frolov, Sergey; Baptista, Antonio M

    2007-05-01

    We present neural network surrogates that provide extremely fast and accurate emulation of a large-scale circulation model for the coupled Columbia River, its estuary and near ocean regions. The circulation model has O(10(7)) degrees of freedom, is highly nonlinear and is driven by ocean, atmospheric and river influences at its boundaries. The surrogates provide accurate emulation of the full circulation code and run over 1000 times faster. Such fast dynamic surrogates will enable significant advances in ensemble forecasts in oceanography and weather.

  6. Fast neural network surrogates for very high dimensional physics-based models in computational oceanography.

    PubMed

    van der Merwe, Rudolph; Leen, Todd K; Lu, Zhengdong; Frolov, Sergey; Baptista, Antonio M

    2007-05-01

    We present neural network surrogates that provide extremely fast and accurate emulation of a large-scale circulation model for the coupled Columbia River, its estuary and near ocean regions. The circulation model has O(10(7)) degrees of freedom, is highly nonlinear and is driven by ocean, atmospheric and river influences at its boundaries. The surrogates provide accurate emulation of the full circulation code and run over 1000 times faster. Such fast dynamic surrogates will enable significant advances in ensemble forecasts in oceanography and weather. PMID:17517493

  7. Analysis of the ballistic impact response of a composite material using FAST Infrared Imagery

    NASA Astrophysics Data System (ADS)

    Marcotte, Frederick; Ouellet, Simon; Farley, Vincent

    2013-05-01

    The level of protection offered by a given ballistic material is typically evaluated in terms of a set of projectiles and their associated velocity at which a certain percentage of the projectiles are expected to perforate. (i.e. FSP 17gr : V50 = 500m/s, 9mm FMJ; V0=500m/s). These metrics give little information about the physical phenomena by which energy is dispersed, spread or absorbed in a specific target material. Aside from post-test inspection of the impacted material, additional information on the target response is traditionally obtained during a test from the use of high speed imaging, whether it is from a single camera aimed at the impact surface or the backface, or from a set of camera allowing full 3-D reconstruction of a deformed surface. Again, this kind of data may be difficult to interpret if the interest is in the way energy is managed in the target in real time. Recent technological progress in scientific grade high-speed infrared (IR) camera demonstrated that these phenomena can straightforwardly be measured using IR thermal imaging. This paper presents promising results obtained from Telops FAST-IR 1500 infrared camera on an aramid-based ballistic composite during an impact from a small caliber fragment simulating projectile (FSP).

  8. Fast response dry-type artificial molecular muscles with [c2]daisy chains.

    PubMed

    Iwaso, Kazuhisa; Takashima, Yoshinori; Harada, Akira

    2016-06-01

    Hierarchically organized myosin and actin filaments found in biological systems exhibit contraction and expansion behaviours that produce work and force by consuming chemical energy. Inspired by these naturally occurring examples, we have developed photoresponsive wet- and dry-type molecular actuators built from rotaxane-based compounds known as [c2]daisy chains (specifically, [c2]AzoCD2 hydrogel and [c2]AzoCD2 xerogel). These actuators were prepared via polycondensation between four-armed poly(ethylene glycol) and a [c2]daisy chain based on α-cyclodextrin as the host component and azobenzene as a photoresponsive guest component. The light-induced actuation arises from the sliding motion of the [c2]daisy chain unit. Ultraviolet irradiation caused the gels to bend towards the light source. The response of the [c2]AzoCD2 xerogel, even under dry conditions, is very fast (7° every second), which is 10,800 times faster than the [c2]AzoCD2 hydrogel (7° every 3 h). In addition, the [c2]AzoCD2 xerogel was used as a crane arm to lift an object using ultraviolet irradiation to produce mechanical work. PMID:27219709

  9. Tunable graphene micro-emitters with fast temporal response and controllable electron emission

    PubMed Central

    Wu, Gongtao; Wei, Xianlong; Gao, Song; Chen, Qing; Peng, Lianmao

    2016-01-01

    Microfabricated electron emitters have been studied for half a century for their promising applications in vacuum electronics. However, tunable microfabricated electron emitters with fast temporal response and controllable electron emission still proves challenging. Here, we report the scaling down of thermionic emitters to the microscale using microfabrication technologies and a Joule-heated microscale graphene film as the filament. The emission current of the graphene micro-emitters exhibits a tunability of up to six orders by a modest gate voltage. A turn-on/off time of less than 1 μs is demonstrated for the graphene micro-emitters, indicating a switching speed about five orders of magnitude faster than their bulky counterparts. Importantly, emission performances of graphene micro-emitters are controllable and reproducible through engineering graphene dimensions by microfabrication technologies, which enables us to fabricate graphene micro-emitter arrays with uniform emission performances. Graphene micro-emitters offer an opportunity of realizing large-scale addressable micro-emitter arrays for vacuum electronics applications. PMID:27160693

  10. Fast-response fiber-optic anemometer with temperature self-compensation.

    PubMed

    Liu, Guigen; Hou, Weilin; Qiao, Wei; Han, Ming

    2015-05-18

    We report a novel fiber-optic anemometer with self-temperature compensation capability based on a Fabry-Pérot interferometer (FPI) formed by a thin silicon film attached to the end face of a single-mode fiber. Guided in the fiber are a visible laser beam from a 635 nm diode laser used to heat the FPI and a white-light in the infrared wavelength range as the signal light to interrogate the optical length of the FPI. Cooling effects on the heated sensor head by wind is converted to a wavelength blueshift of the reflection spectral fringes of the FPI. Self-temperature-compensated measurement of wind speed is achieved by recording the difference in fringe wavelengths when the heating laser is turned on and then off. Large thermal-optic coefficient and thermal expansion coefficient of silicon render a high sensitivity that can also be easily tuned by altering the heating laser power. Furthermore, the large thermal diffusivity and the small mass of the thin silicon film endow a fast sensor response.

  11. Fast response dry-type artificial molecular muscles with [c2]daisy chains

    NASA Astrophysics Data System (ADS)

    Iwaso, Kazuhisa; Takashima, Yoshinori; Harada, Akira

    2016-06-01

    Hierarchically organized myosin and actin filaments found in biological systems exhibit contraction and expansion behaviours that produce work and force by consuming chemical energy. Inspired by these naturally occurring examples, we have developed photoresponsive wet- and dry-type molecular actuators built from rotaxane-based compounds known as [c2]daisy chains (specifically, [c2]AzoCD2 hydrogel and [c2]AzoCD2 xerogel). These actuators were prepared via polycondensation between four-armed poly(ethylene glycol) and a [c2]daisy chain based on α-cyclodextrin as the host component and azobenzene as a photoresponsive guest component. The light-induced actuation arises from the sliding motion of the [c2]daisy chain unit. Ultraviolet irradiation caused the gels to bend towards the light source. The response of the [c2]AzoCD2 xerogel, even under dry conditions, is very fast (7° every second), which is 10,800 times faster than the [c2]AzoCD2 hydrogel (7° every 3 h). In addition, the [c2]AzoCD2 xerogel was used as a crane arm to lift an object using ultraviolet irradiation to produce mechanical work.

  12. Identification of the resonant modes in supersonic impinging jets using fast response pressure sensitive paint

    NASA Astrophysics Data System (ADS)

    Davis, Timothy; Edstrand, Adam; Alvi, Farrukh; Cattafesta, Louis; Yorita, Daisuke; Asai, Keisuke

    2013-11-01

    High speed impinging jets have been the focus of several studies owing to their practical application and resonance dominated flow-field. The current study utilizes fast-response pressure sensitive paint (PSP) to examine the jet instability modes of a Mach 1.5 normally impinging jet. These modes are associated with high amplitude, discrete peaks in the power spectra and can be identified as having either axisymmetric or azimuthal modes. Phase-averaged images are acquired at various nozzle to plate spacings and at frequencies of several kHz. Using an unsteady pressure transducer on the impingement surface as a reference signal, a high speed LED with a wavelength of 460 nm is used to illuminate the PSP. The paint fluorescence is then recorded with a CCD camera. The average pressure distribution is removed from the acquired images, resulting in the phase-averaged unsteady pressure distribution. The processed images reveal axisymmetric modes for all nozzle to plate spacings tested except at 4 jet diameters. At this spacing, three distinct resonant modes are identified.

  13. Tunable graphene micro-emitters with fast temporal response and controllable electron emission.

    PubMed

    Wu, Gongtao; Wei, Xianlong; Gao, Song; Chen, Qing; Peng, Lianmao

    2016-05-10

    Microfabricated electron emitters have been studied for half a century for their promising applications in vacuum electronics. However, tunable microfabricated electron emitters with fast temporal response and controllable electron emission still proves challenging. Here, we report the scaling down of thermionic emitters to the microscale using microfabrication technologies and a Joule-heated microscale graphene film as the filament. The emission current of the graphene micro-emitters exhibits a tunability of up to six orders by a modest gate voltage. A turn-on/off time of less than 1 μs is demonstrated for the graphene micro-emitters, indicating a switching speed about five orders of magnitude faster than their bulky counterparts. Importantly, emission performances of graphene micro-emitters are controllable and reproducible through engineering graphene dimensions by microfabrication technologies, which enables us to fabricate graphene micro-emitter arrays with uniform emission performances. Graphene micro-emitters offer an opportunity of realizing large-scale addressable micro-emitter arrays for vacuum electronics applications.

  14. Fast-response fiber-optic anemometer with temperature self-compensation.

    PubMed

    Liu, Guigen; Hou, Weilin; Qiao, Wei; Han, Ming

    2015-05-18

    We report a novel fiber-optic anemometer with self-temperature compensation capability based on a Fabry-Pérot interferometer (FPI) formed by a thin silicon film attached to the end face of a single-mode fiber. Guided in the fiber are a visible laser beam from a 635 nm diode laser used to heat the FPI and a white-light in the infrared wavelength range as the signal light to interrogate the optical length of the FPI. Cooling effects on the heated sensor head by wind is converted to a wavelength blueshift of the reflection spectral fringes of the FPI. Self-temperature-compensated measurement of wind speed is achieved by recording the difference in fringe wavelengths when the heating laser is turned on and then off. Large thermal-optic coefficient and thermal expansion coefficient of silicon render a high sensitivity that can also be easily tuned by altering the heating laser power. Furthermore, the large thermal diffusivity and the small mass of the thin silicon film endow a fast sensor response. PMID:26074604

  15. MCNPX simulations of the silicon carbide semiconductor detector response to fast neutrons from D-T nuclear reaction

    NASA Astrophysics Data System (ADS)

    Sedlačková, Katarína; Šagátová, Andrea; Zat'ko, Bohumír; Nečas, Vladimír; Solar, Michael; Granja, Carlos

    2016-09-01

    Silicon Carbide (SiC) has been long recognized as a suitable semiconductor material for use in nuclear radiation detectors of high-energy charged particles, gamma rays, X-rays and neutrons. The nuclear interactions occurring in the semiconductor are complex and can be quantified using a Monte Carlo-based computer code. In this work, the MCNPX (Monte Carlo N-Particle eXtended) code was employed to support detector design and analysis. MCNPX is widely used to simulate interaction of radiation with matter and supports the transport of 34 particle types including heavy ions in broad energy ranges. The code also supports complex 3D geometries and both nuclear data tables and physics models. In our model, monoenergetic neutrons from D-T nuclear reaction were assumed as a source of fast neutrons. Their energy varied between 16 and 18.2 MeV, according to the accelerating voltage of the deuterons participating in D-T reaction. First, the simulations were used to calculate the optimum thickness of the reactive film composed of High Density PolyEthylene (HDPE), which converts neutral particles to charged particles and thusly enhancing detection efficiency. The dependency of the optimal thickness of the HDPE layer on the energy of the incident neutrons has been shown for the inspected energy range. Further, from the energy deposited by secondary charged particles and recoiled ions, the detector response was modeled and the effect of the conversion layer on detector response was demonstrated. The results from the simulations were compared with experimental data obtained for a detector covered by a 600 and 1300 μm thick conversion layer. Some limitations of the simulations using MCNPX code are also discussed.

  16. Traditional healers and the "Fast-Track" HIV response: is success possible without them?

    PubMed

    Leclerc-Madlala, Suzanne; Green, Edward; Hallin, Mary

    2016-07-01

    The rapid scale-up of effective HIV prevention strategies is a central theme of the post-2015 health and development agenda. All major global HIV and AIDS funders have aligned their policies and plans to achieve sharp reductions in new HIV infections and reach epidemic control by 2030. In these "fast-track" plans, increased antiretroviral treatment coverage and the attainment of viral suppression are pivotal, and there is firm recognition of the need for countries to mobilise more domestic resources and build stronger community clinic systems. There is little in these bold plans, however, to suggest that the now 30-year-old call by the World Health Organization (WHO) and other organisations to establish systematic collaborations with the traditional health sector will finally be heeded. In the context of sub-Saharan Africa's HIV epidemic, a significant body of literature demonstrates the critical role that traditional healers can play in improving the success of health programmes, including those for HIV prevention. This paper provides a brief history of collaboration with traditional healers for HIV followed by a description of several successful collaborations and discussion of key elements for success. We argue that the traditional health sector is a major resource that has yet to be sufficiently mobilised against HIV. As we shift from a short-term HIV response to a longer-term and more sustainable response, there is an urgent need to accelerate efforts to leverage and partner with the hundreds of thousands of traditional health practitioners who are already providing health services in communities. Failure to better attune our work to the medical pluralism of communities affected by HIV will continue to hinder HIV programming success and help assure that ambitious post-2015 HIV prevention and control goals are not realised.

  17. Traditional healers and the "Fast-Track" HIV response: is success possible without them?

    PubMed

    Leclerc-Madlala, Suzanne; Green, Edward; Hallin, Mary

    2016-07-01

    The rapid scale-up of effective HIV prevention strategies is a central theme of the post-2015 health and development agenda. All major global HIV and AIDS funders have aligned their policies and plans to achieve sharp reductions in new HIV infections and reach epidemic control by 2030. In these "fast-track" plans, increased antiretroviral treatment coverage and the attainment of viral suppression are pivotal, and there is firm recognition of the need for countries to mobilise more domestic resources and build stronger community clinic systems. There is little in these bold plans, however, to suggest that the now 30-year-old call by the World Health Organization (WHO) and other organisations to establish systematic collaborations with the traditional health sector will finally be heeded. In the context of sub-Saharan Africa's HIV epidemic, a significant body of literature demonstrates the critical role that traditional healers can play in improving the success of health programmes, including those for HIV prevention. This paper provides a brief history of collaboration with traditional healers for HIV followed by a description of several successful collaborations and discussion of key elements for success. We argue that the traditional health sector is a major resource that has yet to be sufficiently mobilised against HIV. As we shift from a short-term HIV response to a longer-term and more sustainable response, there is an urgent need to accelerate efforts to leverage and partner with the hundreds of thousands of traditional health practitioners who are already providing health services in communities. Failure to better attune our work to the medical pluralism of communities affected by HIV will continue to hinder HIV programming success and help assure that ambitious post-2015 HIV prevention and control goals are not realised. PMID:27399048

  18. Response of gut microbiota to fasting and hibernation in Syrian hamsters.

    PubMed

    Sonoyama, Kei; Fujiwara, Reiko; Takemura, Naoki; Ogasawara, Toru; Watanabe, Jun; Ito, Hiroyuki; Morita, Tatsuya

    2009-10-01

    Although hibernating mammals wake occasionally to eat during torpor, this period represents a state of fasting. Fasting is known to alter the gut microbiota in nonhibernating mammals; therefore, hibernation may also affect the gut microbiota. However, there are few reports of gut microbiota in hibernating mammals. The present study aimed to compare the gut microbiota in hibernating torpid Syrian hamsters with that in active counterparts by using culture-independent analyses. Hamsters were allocated to either torpid, fed active, or fasted active groups. Hibernation was successfully induced by maintaining darkness at 4 degrees C. Flow cytometry analysis of cecal bacteria showed that 96-h fasting reduced the total gut bacteria. This period of fasting also reduced the concentrations of short chain fatty acids in the cecal contents. In contrast, total bacterial numbers and concentrations of short chain fatty acids were unaffected by hibernation. Denaturing gradient gel electrophoresis of PCR-amplified 16S rRNA gene fragments indicated that fasting and hibernation modulated the cecal microbiota. Analysis of 16S rRNA clone library and species-specific real-time quantitative PCR showed that the class Clostridia predominated in both active and torpid hamsters and that populations of Akkermansia muciniphila, a mucin degrader, were increased by fasting but not by hibernation. From these results, we conclude that the gut microbiota responds differently to fasting and hibernation in Syrian hamsters.

  19. Metabolic and hormonal responses of growing modern meat type chickens to fasting

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The present study compared the effects of fasting on circulating concentrations of glucose, insulin and glucagon in male and female modern meat-type chickens (Ross 708) at three ages (19 d, 33 d and 47 d). Plasma concentrations of glucose were reduced by fasting with reductions of 24.9% (19-d-old),...

  20. Fasting plasma triglycerides predict the glycaemic response to treatment of Type 2 diabetes by gastric electrical stimulation. A novel lipotoxicity paradigm

    PubMed Central

    Lebovitz, H E; Ludvik, B; Yaniv, I; Haddad, W; Schwartz, T; Aviv, R

    2013-01-01

    Background Non-stimulatory, meal-mediated electrical stimulation of the stomach (TANTALUS-DIAMOND) improves glycaemic control and causes modest weight loss in patients with Type 2 diabetes who are inadequately controlled on oral anti-diabetic medications. The magnitude of the glycaemic response in clinical studies has been variable. A preliminary analysis of data from patients who had completed 6 months of treatment indicated that the glycaemic response to the electrical stimulation was inversely related to the baseline fasting plasma triglyceride level. Method An analysis of 40 patients who had had detailed longitudinal studies for 12 months. Results Twenty-two patients with fasting plasma triglycerides ≤ 1.7 mmol/l had mean decreases in HbA1c after 3, 6 and 12 months of gastric contraction modulation treatment of −15 ± 2.1 mmol/mol (−1.39 ± 0.20%), −16 ± 2.2 mmol/mol (−1.48 ± 0.20%) and −14 ± 3.0 mmol/mol (−1.31 ± 0.26%), respectively. In contrast, 18 patients with fasting plasma triglyceride > 1.7 mmol/l had mean decreases in HbA1c of −7 ± 1.7 mmol/mol (−0.66 ± 0.16%), −5 ± 1.6 mmol/mol (−0.44 ± 0.18%) and −5 ± 1.7 mmol/mol (−0.42 ± 0.16%), respectively. Pearson's correlation coefficient between fasting plasma triglyceride and decreases in HbA1c at 12 months of treatment was 0.34 (P < 0.05). Homeostasis model assessment of insulin resistance was unchanged during 12 months of treatment in patients with high baseline fasting triglycerides, while it progressively improved in patients with low fasting plasma triglycerides. Patients with low fasting plasma triglycerides had a tendency to lose more weight than those with high fasting plasma triglycerides, but this did not achieve statistical significance. Conclusions The data presented suggest the existance of a triglyceride lipotoxic mechanism that interferes with gastric/neural mediated pathways that can regulate glycaemic control in patients with type 2 diabetes. The data

  1. Fast response organic light-emitting diode for visible optical communication

    NASA Astrophysics Data System (ADS)

    Fukuda, Takeshi; Taniguchi, Yoshio

    2008-02-01

    We examined fast response organic light-emitting diodes (OLEDs) for new applications of visible optical communications. For the practical use in this field, the fast transmission speed of OLEDs is required to be used in many applications, but the low carrier mobility of organic materials and the long fluorescence lifetime (FL) organic emitting materials limit the transmission speed of OLEDs. Therefore, we investigated the influence of the FL on transient properties of photoluminescence (PL), which were evaluated by the frequency dependence of PL intensity excited by a modulated violet laser diode. The FLs of several organic emitting materials were also measured, and we found the clear relationship between the FL and the transient properties of PL intensity. The fastest cutoff frequency of PL intensity was achieved 160 MHz utilizing short FL material, 1,4-bis[2-[4-[N,N-di(ptolyl)amino]phenl]vinyl]benzene. We also investigated another way to increase the transmission speed utilizing a semiconductor-organic multilayer structure, of which ZnS was used as an electron transport layer. The maximum cutoff frequency of this device was achieved 20.3 MHz, while that of the organic multilayer structure was 8.7 MHz at a sine wave voltage of 7 V and a bias voltage of 5 V. This result indicates that the high carrier mobility of the ZnS layer causes the increase in the transmission speed of OLEDs. We demonstrated one institutive demonstrator module of visible optical communications, which consisted of the transceiver module with an OLED and the pen-type receiver module with a photo-diode at a point. The movie files was transmitted at a speed of 230 kbps, when the point of a pen-type receiver module approaches the emitting area of an OLED. Furthermore, the pseudo-random signal with 1Mbps was also transmitted with this visible optical communication system. Such a system enables to connect between transceiver and receiver module without precious alignment because of the large

  2. RF Modeling of a Helical Kicker for Fast Chopping

    SciTech Connect

    Awida, Mohamed; Chen, Alex; Khabiboulline, Timergali; Saewert, Gregory; Yakovlev, Vyacheslav

    2015-06-01

    High intensity proton particle accelerators that supports several simultaneous physics experiments requires sharing the beam. A bunch by bunch beam chopper system located after the Radio Frequency Quadrupole (RFQ) is required in this case to structure the beam in the proper bunch format required by the several experiments. The unused beam will need to be kicked out of the beam path and is disposed in a beam dumb. In this paper, we report on the RF modeling results of a proposed helical kicker. Two beam kickers constitutes the proposed chopper. The beam sequence is formed by kicking in or out the beam bunches from the streamline. The chopper was developed for Project X Injection Experiment (PXIE).

  3. Thermal coupling between neutral hydrogen and protons in the fast solar wind: Models and inferences

    NASA Astrophysics Data System (ADS)

    Allen, Lorraine Ann

    2001-10-01

    In response to the recent Spartan and UVCS/SOHO observations of Ly α spectral line profiles in the inner corona implying large temperature anisotropies and proton temperatures as high as 6 × 106 K [ Kohl et al., 1996, 1997]1, we investigate the thermal coupling between neutral hydrogen atoms and protons in the fast solar wind. We include charge exchange between neutrals and protons, radiative recombination, collisional ionization of the neutrals, and the effects of Alfvén waves, described by a single frequency or a spectrum. We follow the approach developed by Olsen et al. [1994]2 to incorporate the collisional interaction between the neutrals and protons and the resulting wave motion of the neutrals. A fluid approach is used in which the neutrals are treated as test particles in a background electron- proton solar wind driven out from the Sun by thermal and Alfvén wave pressure against gravity. Coulomb collisions and thermal conductivity of the electrons and protons are included, as well as the allowance for non- radially expanding flow tubes and additional heating to the electrons and protons. We study the behavior of the neutral hydrogen in the solar wind for cases with isotropic and anisotropic proton temperatures. Our model solutions show, and we confirm by analytical calculation, that the effective temperature, T⊥H(eff) , incorporating both random and wave motions of the neutral hydrogen, is independent of Alfvén wave frequency. We find that for solutions with either isotropic or anisotropic proton temperatures the proton and neutral hydrogen effective temperatures and outflow velocities are comparable, with a temperature difference less than 5 × 105 K, below 3 Rs. For plasma conditions typical of the fast solar wind, these results imply that the measured Ly α spectral line profiles, from which the neutral hydrogen temperature, anisotropy ratio, and outflow velocity are inferred, are equivalent to measurements of protons below 3 R s. To relate our

  4. A Neutron Star–White Dwarf Binary Model for Repeating Fast Radio Burst 121102

    NASA Astrophysics Data System (ADS)

    Gu, Wei-Min; Dong, Yi-Ze; Liu, Tong; Ma, Renyi; Wang, Junfeng

    2016-06-01

    We propose a compact binary model for the fast radio burst (FRB) repeaters, where the system consists of a magnetic white dwarf (WD) and a neutron star (NS) with strong bipolar magnetic fields. When the WD fills its Roche lobe, mass transfer will occur from the WD to the NS through the inner Lagrange point. The accreted magnetized materials may trigger magnetic reconnection when they approach the NS surface, and therefore the electrons can be accelerated to an ultra-relativistic speed. In this scenario, the curvature radiation of the electrons moving along the NS magnetic field lines can account for the characteristic frequency and the timescale of an FRB. Owing to the conservation of angular momentum, the WD may be kicked away after a burst, and the next burst may appear when the system becomes semi-detached again through the gravitational radiation. By comparing our analyses with the observations, we show that such an intermittent Roche-lobe overflow mechanism can be responsible for the observed repeating behavior of FRB 121102.

  5. A Neutron Star-White Dwarf Binary Model for Repeating Fast Radio Burst 121102

    NASA Astrophysics Data System (ADS)

    Gu, Wei-Min; Dong, Yi-Ze; Liu, Tong; Ma, Renyi; Wang, Junfeng

    2016-06-01

    We propose a compact binary model for the fast radio burst (FRB) repeaters, where the system consists of a magnetic white dwarf (WD) and a neutron star (NS) with strong bipolar magnetic fields. When the WD fills its Roche lobe, mass transfer will occur from the WD to the NS through the inner Lagrange point. The accreted magnetized materials may trigger magnetic reconnection when they approach the NS surface, and therefore the electrons can be accelerated to an ultra-relativistic speed. In this scenario, the curvature radiation of the electrons moving along the NS magnetic field lines can account for the characteristic frequency and the timescale of an FRB. Owing to the conservation of angular momentum, the WD may be kicked away after a burst, and the next burst may appear when the system becomes semi-detached again through the gravitational radiation. By comparing our analyses with the observations, we show that such an intermittent Roche-lobe overflow mechanism can be responsible for the observed repeating behavior of FRB 121102.

  6. Particle size distributions from laboratory-scale biomass fires using fast response instruments

    NASA Astrophysics Data System (ADS)

    Hosseini, S.; Qi, L.; Cocker, D.; Weise, D.; Miller, A.; Shrivastava, M.; Miller, W.; Mahalingam, S.; Princevac, M.; Jung, H.

    2010-04-01

    Particle size distribution from biomass combustion is an important parameter as it affects air quality, climate modelling and health effects. To date particle size distributions reported from prior studies vary not only due to difference in fuels but also difference in experimental conditions. This study aims to report characteristics of particle size distribution in a well controlled repeatable lab scale biomass fires for southwestern US fuels. The combustion facility at the USDA Forest Service's Fire Science Laboratory (FSL), Missoula, MT provided repeatable combustion and dilution environment ideal for particle size distribution study. For a variety of fuels tested the major mode of particle size distribution was in the range of 29 to 52 nm, which was attributable to dilution of the fresh smoke. Comparing volume size distribution from Fast Mobility Particle Sizer (FMPS) and Aerodynamic Particle Sizer (APS) measurements, ~30% of particle volume was attributable to the particles ranging from 0.5 to 10 μm for PM10. Geometric mean diameter rapidly increased during flaming and gradually decreased during mixed and smoldering phase combustion. Most of fuels gave unimodal distribution during flaming phase and strong biomodal distribution during smoldering phase. The mode of combustion (flaming, mixed and smoldering) could be better distinguished using slopes in Modified Combustion Efficiency (MCE) vs. geometric mean diameter from each mode of combustion than only using MCE values.

  7. Fast labile carbon turnover obscures sensitivity of heterotrophic respiration from soil to temperature: A model analysis

    NASA Astrophysics Data System (ADS)

    Gu, Lianhong; Post, Wilfred M.; King, Anthony W.

    2004-03-01

    Labile carbon, although often a small fraction of soil organic carbon (SOC), significantly affects heterotrophic respiration at short timescales because of its rapid decomposition. However, in the current literature, most soil respiration measurements are interpreted without simultaneous information on labile carbon pool dynamics. Sensitivity of soil respiration to temperature is routinely derived directly from field observations, and such relationships have been used to extrapolate effects of global change (e.g., warming) on carbon emission from SOC. Here we use a multipool SOC model to demonstrate the impacts of seasonal fluctuations of labile carbon pools on interpretation of soil respiration measurements. We find that labile carbon pool sizes vary widely in response to seasonal changes in representative plant material inputs and temperature even though the model is operating at equilibrium in terms of annual means. Convolution of the dynamics of fast turnover carbon pools and temporal progression in temperature lead to misrepresentation and misinterpretation of the heterotrophic respiration-temperature relationships estimated from bulk soil CO2 exchanges. Temperature sensitivity is overestimated when the variations of labile carbon pools and temperature are in phase and underestimated when they are out of phase. Furthermore, with normally used observation time windows (weeks to a year), temperature sensitivity is more likely to be underestimated. A distortion of temperature sensitivity (Q10) from 2 (actual, sensitive dependence on temperature) to nearly 1 (false, no dependence on temperature) is shown. Applying estimated temperature sensitivity parameter back into the model considerably overestimates soil carbon storage at equilibrium. Our findings indicate that caution must be taken when soil respiration-temperature relationships are evaluated based on bulk soil observations and when sensitivity of soil respiration to temperature estimated directly under field

  8. Acceleration through a Holistic Support Model: An Implementation and Outcomes Analysis of FastStart@CCD

    ERIC Educational Resources Information Center

    Edgecombe, Nikki; Jaggars, Shanna Smith; Baker, Elaine DeLott; Bailey, Thomas

    2013-01-01

    Originally designed for students who test into at least two levels of developmental education in a particular subject area, FastStart is a compressed course program model launched in 2005 at the Community College of Denver (CCD). The program combines multiple semester-length courses into a single intensive semester, while providing case…

  9. Continuous Evaluation of Fast Processes in Climate Models Using Arm Measurements

    SciTech Connect

    Zhang, Minghua

    2015-01-02

    Under the support of this grant, we investigated the fast process of interaction of clouds, shallow convection, and boundary layer turbulence and their parameterizations. Main accomplishments involve two things. One is the understanding of the physical mechanisms of low cloud feedbacks; the second is the development and evaluation of convection and cloud parameterizations in climate models.

  10. Psychological Plausibility of the Theory of Probabilistic Mental Models and the Fast and Frugal Heuristics

    ERIC Educational Resources Information Center

    Dougherty, Michael R.; Franco-Watkins, Ana M.; Thomas, Rick

    2008-01-01

    The theory of probabilistic mental models (PMM; G. Gigerenzer, U. Hoffrage, & H. Kleinbolting, 1991) has had a major influence on the field of judgment and decision making, with the most recent important modifications to PMM theory being the identification of several fast and frugal heuristics (G. Gigerenzer & D. G. Goldstein, 1996). These…

  11. Near threshold conditions justify critical gradient model for Alvenic mode driven relaxation of fast ions

    NASA Astrophysics Data System (ADS)

    Gorelenkov, Nikolai; Ghantous, Katy; Heidbrink, William; van Zeeland, Michael

    2013-10-01

    Future burning plasma performance will be limited by the constraints to confine energetic superalfvenic fusion products, which can drive several low frequency Alfvénic instabilities. Expected multiple resonances help to justify the model developed recently, called critical gradient or 1.5D reduced quasilinear diffusion model. Similar conditions are expected in burning plasmas with TAE instabilities in a non virulent nonlinear regime. The 1.5D model make use of TAE/RSAEs linear theory. One critical element of the presented model is that it requires averaging over the time comparable to the fast ion slowing down. Another element is that the fast ion diffusion near the resonance does not flatten the distribution function whose gradient is maintained by the collision scattering. Further validations of this model justify its use in case of relatively high collisions. With the parametric plasma dependencies embedded in the model and with the quantitative normalization to NOVA-K growth rates the 1.5D model application to DIII-D experiments is well positioned for validations. Good agreement is summarized here for absolute values of the deduced neutron rate and for the time behavior of fast ion losses near the AE activity thresholds. 1.5D model is applicable for ITER and other BPs. Supported in part by the U.S. Department of Energy under the contract DE-AC02-09CH11466.

  12. Extending food deprivation reverses the short-term lipolytic response to fasting: role of the triacylglycerol/fatty acid cycle.

    PubMed

    Weber, Jean-Michel; Reidy, Shannon P

    2012-05-01

    The effects of short-term food deprivation on lipid metabolism are well documented, but little is known about prolonged fasting. This study monitored the kinetics of glycerol (rate of appearance, R(a) glycerol) and non-esterified fatty acids (R(a) NEFA) in fasting rabbits. Our goals were to determine whether lipolysis is stimulated beyond values seen for short-term fasting, and to characterize the roles of primary (intracellular) and secondary (with transit through the circulation) triacylglycerol/fatty acid cycling (TAG/FA cycling) in regulating fatty acid allocation to oxidation or re-esterification. R(a) glycerol (9.62±0.72 to 15.29±0.96 μmol kg(-1) min(-1)) and R(a) NEFA (18.05±2.55 to 31.25±1.93 μmol kg(-1) min(-1)) were stimulated during the first 2 days of fasting, but returned to baseline after 4 days. An initial increase in TAG/FA cycling was followed by a reduction below baseline after 6 days without food, with primary and secondary cycling contributing to these responses. We conclude that the classic activation of lipolysis caused by short-term fasting is abolished when food deprivation is prolonged. High rates of re-esterification may become impossible to sustain, and TAG/FA cycling could decrease to reduce its cost to 3% of total energy expenditure. Throughout prolonged fasting, fatty acid metabolism gradually shifts towards increased oxidation and reduced re-esterification. Survival is achieved by pressing fuel selection towards the fatty acid dominance of energy metabolism and by slowing substrate cycles to assist metabolic suppression. However, TAG/FA cycling remains active even after prolonged fasting, suggesting that re-esterification is a crucial mechanism that cannot be stopped without harmful consequences.

  13. Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults

    PubMed Central

    Chowdhury, E A; Richardson, J D; Tsintzas, K; Thompson, D; Betts, J A

    2016-01-01

    Background/Objectives: Breakfast omission is positively associated with obesity and increased risk of disease. However, little is known about the acute effects of extended morning fasting upon subsequent energy intake and associated metabolic/regulatory factors in obese adults. Subjects/Methods: In a randomised cross-over design, 24 obese men (n=8) and women (n=16) extended their overnight fast by omitting breakfast consumption or ingesting a typical carbohydrate-rich breakfast of 2183±393 kJ (521±94 kcal), before an ad libitum pasta lunch 3 h later. Blood samples were obtained throughout the day until 3 h post lunch and analysed for hormones implicated in appetite regulation, along with metabolic outcomes and subjective appetite measures. Results: Lunch intake was unaffected by extended morning fasting (difference=218 kJ, 95% confidence interval −54 kJ, 490 kJ; P=0.1) resulting in lower total intake in the fasting trial (difference=−1964 kJ, 95% confidence interval −1645 kJ, −2281 kJ; P<0.01). Systemic concentrations of peptide tyrosine–tyrosine and leptin were lower during the afternoon following morning fasting (P⩽0.06). Plasma-acylated ghrelin concentrations were also lower following the ad libitum lunch in the fasting trial (P<0.05) but this effect was not apparent for total ghrelin (P⩾0.1). Serum insulin concentrations were greater throughout the afternoon in the fasting trial (P=0.05), with plasma glucose also greater 1 h after lunch (P<0.01). Extended morning fasting did not result in greater appetite ratings after lunch, with some tendency for lower appetite 3 h post lunch (P=0.09). Conclusions: We demonstrate for the first time that, in obese adults, extended morning fasting does not cause compensatory intake during an ad libitum lunch nor does it increase appetite during the afternoon. Morning fasting reduced satiety hormone responses to a subsequent lunch meal but counterintuitively also reduced concentrations of

  14. Dose-response model for teratological experiments involving quantal responses

    SciTech Connect

    Rai, K.; Van Ryzin, J.

    1985-03-01

    This paper introduces a dose-response model for teratological quantal response data where the probability of response for an offspring from a female at a given dose varies with the litter size. The maximum likelihood estimators for the parameters of the model are given as the solution of a nonlinear iterative algorithm. Two methods of low-dose extrapolation are presented, one based on the litter size distribution and the other a conservative method. The resulting procedures are then applied to a teratological data set from the literature.

  15. Response Surface Modeling Using Multivariate Orthogonal Functions

    NASA Technical Reports Server (NTRS)

    Morelli, Eugene A.; DeLoach, Richard

    2001-01-01

    A nonlinear modeling technique was used to characterize response surfaces for non-dimensional longitudinal aerodynamic force and moment coefficients, based on wind tunnel data from a commercial jet transport model. Data were collected using two experimental procedures - one based on modem design of experiments (MDOE), and one using a classical one factor at a time (OFAT) approach. The nonlinear modeling technique used multivariate orthogonal functions generated from the independent variable data as modeling functions in a least squares context to characterize the response surfaces. Model terms were selected automatically using a prediction error metric. Prediction error bounds computed from the modeling data alone were found to be- a good measure of actual prediction error for prediction points within the inference space. Root-mean-square model fit error and prediction error were less than 4 percent of the mean response value in all cases. Efficacy and prediction performance of the response surface models identified from both MDOE and OFAT experiments were investigated.

  16. Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses.

    PubMed

    Lara, Alvaro R; Taymaz-Nikerel, Hilal; Mashego, Mlawule R; van Gulik, Walter M; Heijnen, Joseph J; Ramírez, Octavio T; van Winden, Wouter A

    2009-12-15

    The response of Escherichia coli cells to transient exposure (step increase) in substrate concentration and anaerobiosis leading to mixed-acid fermentation metabolism was studied in a two-compartment bioreactor system consisting of a stirred tank reactor (STR) connected to a mini-plug-flow reactor (PFR: BioScope, 3.5 mL volume). Such a system can mimic the situation often encountered in large-scale, fed-batch bioreactors. The STR represented the zones of a large-scale bioreactor that are far from the point of substrate addition and that can be considered as glucose limited, whereas the PFR simulated the region close to the point of substrate addition, where glucose concentration is much higher than in the rest of the bioreactor. In addition, oxygen-poor and glucose-rich regions can occur in large-scale bioreactors. The response of E. coli to these large-scale conditions was simulated by continuously pumping E. coli cells from a well stirred, glucose limited, aerated chemostat (D = 0.1 h(-1)) into the mini-PFR. A glucose pulse was added at the entrance of the PFR. In the PFR, a total of 11 samples were taken in a time frame of 92 s. In one case aerobicity in the PFR was maintained in order to evaluate the effects of glucose overflow independently of oxygen limitation. Accumulation of acetate and formate was detected after E. coli cells had been exposed for only 2 s to the glucose-rich (aerobic) region in the PFR. In the other case, the glucose pulse was also combined with anaerobiosis in the PFR. Glucose overflow combined with anaerobiosis caused the accumulation of formate, acetate, lactate, ethanol, and succinate, which were also detected as soon as 2 s after of exposure of E. coli cells to the glucose and O(2) gradients. This approach (STR-mini-PFR) is useful for a better understanding of the fast dynamic phenomena occurring in large-scale bioreactors and for the design of modified strains with an improved behavior under large-scale conditions. PMID:19685524

  17. Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses.

    PubMed

    Lara, Alvaro R; Taymaz-Nikerel, Hilal; Mashego, Mlawule R; van Gulik, Walter M; Heijnen, Joseph J; Ramírez, Octavio T; van Winden, Wouter A

    2009-12-15

    The response of Escherichia coli cells to transient exposure (step increase) in substrate concentration and anaerobiosis leading to mixed-acid fermentation metabolism was studied in a two-compartment bioreactor system consisting of a stirred tank reactor (STR) connected to a mini-plug-flow reactor (PFR: BioScope, 3.5 mL volume). Such a system can mimic the situation often encountered in large-scale, fed-batch bioreactors. The STR represented the zones of a large-scale bioreactor that are far from the point of substrate addition and that can be considered as glucose limited, whereas the PFR simulated the region close to the point of substrate addition, where glucose concentration is much higher than in the rest of the bioreactor. In addition, oxygen-poor and glucose-rich regions can occur in large-scale bioreactors. The response of E. coli to these large-scale conditions was simulated by continuously pumping E. coli cells from a well stirred, glucose limited, aerated chemostat (D = 0.1 h(-1)) into the mini-PFR. A glucose pulse was added at the entrance of the PFR. In the PFR, a total of 11 samples were taken in a time frame of 92 s. In one case aerobicity in the PFR was maintained in order to evaluate the effects of glucose overflow independently of oxygen limitation. Accumulation of acetate and formate was detected after E. coli cells had been exposed for only 2 s to the glucose-rich (aerobic) region in the PFR. In the other case, the glucose pulse was also combined with anaerobiosis in the PFR. Glucose overflow combined with anaerobiosis caused the accumulation of formate, acetate, lactate, ethanol, and succinate, which were also detected as soon as 2 s after of exposure of E. coli cells to the glucose and O(2) gradients. This approach (STR-mini-PFR) is useful for a better understanding of the fast dynamic phenomena occurring in large-scale bioreactors and for the design of modified strains with an improved behavior under large-scale conditions.

  18. Two-dimensional models of early-type fast rotating stars: new challenges in stellar physics

    NASA Astrophysics Data System (ADS)

    Rieutord, M.; Espinosa Lara, F.

    2013-12-01

    Two-dimensional models of rapidly rotating stars are already unavoidable for the interpretation of interferometric or asteroseismic data of this kind of stars. When combined with time evolution, they will allow the including of a more accurate physics for the computation of element transport and the determination of surface abundances. In addition, modeling the evolution of rotation will improve gyrochronology. Presently, two-dimensional ESTER models predict the structure and the large-scale flows (differential rotation and meridional circulation) of stars with mass larger than 1.7 M⊙ at any rotation rate. Main sequence evolution can be mimicked by varying the hydrogen content of the convective core. Models have been successfully tested on half a dozen of nearby fast rotating stars observed with optical or infra-red interferometers. They are now the right tool to investigate the oscillation spectrum of early-type fast rotators.

  19. Global solution for a kinetic chemotaxis model with internal dynamics and its fast adaptation limit

    NASA Astrophysics Data System (ADS)

    Liao, Jie

    2015-12-01

    A nonlinear kinetic chemotaxis model with internal dynamics incorporating signal transduction and adaptation is considered. This paper is concerned with: (i) the global solution for this model, and, (ii) its fast adaptation limit to Othmer-Dunbar-Alt type model. This limit gives some insight to the molecular origin of the chemotaxis behaviour. First, by using the Schauder fixed point theorem, the global existence of weak solution is proved based on detailed a priori estimates, under quite general assumptions. However, the Schauder theorem does not provide uniqueness, so additional analysis is required to be developed for uniqueness. Next, the fast adaptation limit of this model is derived by extracting a weak convergence subsequence in measure space. For this limit, the first difficulty is to show the concentration effect on the internal state. Another difficulty is the strong compactness argument on the chemical potential, which is essential for passing the nonlinear kinetic equation to the weak limit.

  20. Absorption of Fast Waves at Moderate to High Ion Cyclotron Harmonics: Experimental Results and Theoretical Models

    NASA Astrophysics Data System (ADS)

    Pinsker, R. I.; Choi, M.; Prater, R.; Heidbrink, W. W.; Luo, Y.; Baity, F. W.; Murakami, M.; Porkolab, M.

    2006-10-01

    Strong absorption of fast Alfvén waves (FW) by ion cyclotron damping has been observed in DIII-D at the 4th and 5th harmonic of an injected beam while only weak absorption is observed at the 8th harmonic. The experimental results are compared with three different theoretical models; differences between the predictions of the models suggest the possible importance of finite-width orbit effects at high harmonics. In a linear model, it is found that damping on fast ions from neutral beam injection can be significant even at the 8th harmonic under experimentally relevant conditions. This is tested in experiments in DIII-D with FW power at 60 MHz and at 116 MHz. A novel Dα charge exchange recombination diagnostic is used to observe interaction of the FW power with beam ions. The results are compared with modeling with quasilinear and with orbit-following codes.

  1. Computer studies on plasmoids and TCRs by the spontaneous fast reconnection model

    NASA Astrophysics Data System (ADS)

    Zheng, L.; Ugai, M.; Kondoh, K.

    The temporal dynamics of plasmoids propagating tailward and the associated traveling compression regions TCRs in the surrounding magnetic lobe region are studied by using high-resolution three-dimensional MHD simulations on the basis of the spontaneous fast reconnection model Once the fast reconnection mechanism is triggered a large-scale plasmoid develops and propagates at the end of the fast reconnection Alfvenic jet between a pair of standing slow shocks Accordingly the TCR is caused in the tail lobe region by the interaction between the plasmoid and the ambient magnetic field The complicated inner structure of the plasmoid and the dynamics of TCR are analyzed in details and it is demonstrated that the simulation results are in good agreement with the satellite observations

  2. Adaptive responses of GLUT-4 and citrate synthase in fast-twitch muscle of voluntary running rats

    NASA Technical Reports Server (NTRS)

    Henriksen, E. J.; Halseth, A. E.

    1995-01-01

    Glucose transporter (GLUT-4) protein, hexokinase, and citrate synthase (proteins involved in oxidative energy production from blood glucose catabolism) increase in response to chronically elevated neuromuscular activity. It is currently unclear whether these proteins increase in a coordinated manner in response to this stimulus. Therefore, voluntary wheel running (WR) was used to chronically overload the fast-twitch rat plantaris muscle and the myocardium, and the early time courses of adaptative responses of GLUT-4 protein and the activities of hexokinase and citrate synthase were characterized and compared. Plantaris hexokinase activity increased 51% after just 1 wk of WR, whereas GLUT-4 and citrate synthase were increased by 51 and 40%, respectively, only after 2 wk of WR. All three variables remained comparably elevated (+50-64%) through 4 wk of WR. Despite the overload of the myocardium with this protocol, no substantial elevations in these variables were observed. These findings are consistent with a coordinated upregulation of GLUT-4 and citrate synthase in the fast-twitch plantaris, but not in the myocardium, in response to this increased neuromuscular activity. Regulation of hexokinase in fast-twitch muscle appears to be uncoupled from regulation of GLUT-4 and citrate synthase, as increases in the former are detectable well before increases in the latter.

  3. Generalized IRT Models for Extreme Response Style

    ERIC Educational Resources Information Center

    Jin, Kuan-Yu; Wang, Wen-Chung

    2014-01-01

    Extreme response style (ERS) is a systematic tendency for a person to endorse extreme options (e.g., strongly disagree, strongly agree) on Likert-type or rating-scale items. In this study, we develop a new class of item response theory (IRT) models to account for ERS so that the target latent trait is free from the response style and the tendency…

  4. A TURBULENCE-DRIVEN MODEL FOR HEATING AND ACCELERATION OF THE FAST WIND IN CORONAL HOLES

    SciTech Connect

    Verdini, A.; Velli, M.; Matthaeus, W. H.; Oughton, S.; Dmitruk, P.

    2010-01-10

    A model is presented for generation of fast solar wind in coronal holes, relying on heating that is dominated by turbulent dissipation of MHD fluctuations transported upward in the solar atmosphere. Scale-separated transport equations include large-scale fields, transverse Alfvenic fluctuations, and a small compressive dissipation due to parallel shears near the transition region. The model accounts for proton temperature, density, wind speed, and fluctuation amplitude as observed in remote sensing and in situ satellite data.

  5. ModelOMatic: fast and automated model selection between RY, nucleotide, amino acid, and codon substitution models.

    PubMed

    Whelan, Simon; Allen, James E; Blackburne, Benjamin P; Talavera, David

    2015-01-01

    Molecular phylogenetics is a powerful tool for inferring both the process and pattern of evolution from genomic sequence data. Statistical approaches, such as maximum likelihood and Bayesian inference, are now established as the preferred methods of inference. The choice of models that a researcher uses for inference is of critical importance, and there are established methods for model selection conditioned on a particular type of data, such as nucleotides, amino acids, or codons. A major limitation of existing model selection approaches is that they can only compare models acting upon a single type of data. Here, we extend model selection to allow comparisons between models describing different types of data by introducing the idea of adapter functions, which project aggregated models onto the originally observed sequence data. These projections are implemented in the program ModelOMatic and used to perform model selection on 3722 families from the PANDIT database, 68 genes from an arthropod phylogenomic data set, and 248 genes from a vertebrate phylogenomic data set. For the PANDIT and arthropod data, we find that amino acid models are selected for the overwhelming majority of alignments; with progressively smaller numbers of alignments selecting codon and nucleotide models, and no families selecting RY-based models. In contrast, nearly all alignments from the vertebrate data set select codon-based models. The sequence divergence, the number of sequences, and the degree of selection acting upon the protein sequences may contribute to explaining this variation in model selection. Our ModelOMatic program is fast, with most families from PANDIT taking fewer than 150 s to complete, and should therefore be easily incorporated into existing phylogenetic pipelines. ModelOMatic is available at https://code.google.com/p/modelomatic/.

  6. Are Live Ultrasound Models Replaceable? Traditional versus Simulated Education Module for FAST Exam

    PubMed Central

    Bentley, Suzanne; Mudan, Gurpreet; Strother, Christopher; Wong, Nelson

    2015-01-01

    Introduction The focused assessment with sonography for trauma (FAST) is a commonly used and life-saving tool in the initial assessment of trauma patients. The recommended emergency medicine (EM) curriculum includes ultrasound and studies show the additional utility of ultrasound training for medical students. EM clerkships vary and often do not contain formal ultrasound instruction. Time constraints for facilitating lectures and hands-on learning of ultrasound are challenging. Limitations on didactics call for development and inclusion of novel educational strategies, such as simulation. The objective of this study was to compare the test, survey, and performance of ultrasound between medical students trained on an ultrasound simulator versus those trained via traditional, hands-on patient format. Methods This was a prospective, blinded, controlled educational study focused on EM clerkship medical students. After all received a standardized lecture with pictorial demonstration of image acquisition, students were randomized into two groups: control group receiving traditional training method via practice on a human model and intervention group training via practice on an ultrasound simulator. Participants were tested and surveyed on indications and interpretation of FAST and training and confidence with image interpretation and acquisition before and after this educational activity. Evaluation of FAST skills was performed on a human model to emulate patient care and practical skills were scored via objective structured clinical examination (OSCE) with critical action checklist. Results There was no significant difference between control group (N=54) and intervention group (N=39) on pretest scores, prior ultrasound training/education, or ultrasound comfort level in general or on FAST. All students (N=93) showed significant improvement from pre- to post-test scores and significant improvement in comfort level using ultrasound in general and on FAST (p<0.001). There

  7. On Compensation in Multidimensional Response Modeling

    ERIC Educational Resources Information Center

    van der Linden, Wim J.

    2012-01-01

    The issue of compensation in multidimensional response modeling is addressed. We show that multidimensional response models are compensatory in their ability parameters if and only if they are monotone. In addition, a minimal set of assumptions is presented under which the MLEs of the ability parameters are also compensatory. In a recent series of…

  8. Identification of a Semiparametric Item Response Model

    ERIC Educational Resources Information Center

    Peress, Michael

    2012-01-01

    We consider the identification of a semiparametric multidimensional fixed effects item response model. Item response models are typically estimated under parametric assumptions about the shape of the item characteristic curves (ICCs), and existing results suggest difficulties in recovering the distribution of individual characteristics under…

  9. Exupery volcano fast response system - The event detection and waveform classification system

    NASA Astrophysics Data System (ADS)

    Hammer, Conny; Ohrnberger, Matthias

    2010-05-01

    volcanic signal classification scheme as early as new events have been identified. For implementation issues we make use of the Hidden Markov Toolkit (HTK), a software package which is mainly intended for speech recognition. For the training procedure we first extract a valuable set of wave field parameters (here, polarization and spectral attributes) in a sliding window fashion from an unlabeled continuous data stream. In the following these parameters are used to extract a fixed number of clusters in the feature space. Based on this general multivariate description of the overall data set we start building particular event classifiers from a single waveform example based on the cluster description learned before. We will present first results of the automatic classification process to show that the system is able to provide a robust event classification without previously existing training events and hence is a step forward for volcano fast response systems.

  10. Joint Modeling of Ability and Differential Speed Using Responses and Response Times.

    PubMed

    Fox, Jean-Paul; Marianti, Sukaesi

    2016-01-01

    With computerized testing, it is possible to record both the responses of test takers to test questions (i.e., items) and the amount of time spent by a test taker in responding to each question. Various models have been proposed that take into account both test-taker ability and working speed, with the many models assuming a constant working speed throughout the test. The constant working speed assumption may be inappropriate for various reasons. For example, a test taker may need to adjust the pace due to time mismanagement, or a test taker who started out working too fast may reduce the working speed to improve accuracy. A model is proposed here that allows for variable working speed. An illustration of the model using the Amsterdam Chess Test data is provided. PMID:27269482

  11. Computational fluid dynamics modelling of biomass fast pyrolysis in fluidised bed reactors, focusing different kinetic schemes.

    PubMed

    Ranganathan, Panneerselvam; Gu, Sai

    2016-08-01

    The present work concerns with CFD modelling of biomass fast pyrolysis in a fluidised bed reactor. Initially, a study was conducted to understand the hydrodynamics of the fluidised bed reactor by investigating the particle density and size, and gas velocity effect. With the basic understanding of hydrodynamics, the study was further extended to investigate the different kinetic schemes for biomass fast pyrolysis process. The Eulerian-Eulerian approach was used to model the complex multiphase flows in the reactor. The yield of the products from the simulation was compared with the experimental data. A good comparison was obtained between the literature results and CFD simulation. It is also found that CFD prediction with the advanced kinetic scheme is better when compared to other schemes. With the confidence obtained from the CFD models, a parametric study was carried out to study the effect of biomass particle type and size and temperature on the yield of the products.

  12. MODELING SUPER-FAST MAGNETOSONIC WAVES OBSERVED BY SDO IN ACTIVE REGION FUNNELS

    SciTech Connect

    Ofman, L.; Liu, W.; Title, A.; Aschwanden, M.

    2011-10-20

    Recently, quasi-periodic, rapidly propagating waves have been observed in extreme ultraviolet by the Solar Dynamics Observatory/Atmospheric Imaging Assembly (AIA) instrument in about 10 flare/coronal mass ejection (CME) events thus far. A typical example is the 2010 August 1 C3.2 flare/CME event that exhibited arc-shaped wave trains propagating in an active region (AR) magnetic funnel with {approx}5% intensity variations at speeds in the range of 1000-2000 km s{sup -1}. The fast temporal cadence and high sensitivity of AIA enabled the detection of these waves. We identify them as fast magnetosonic waves driven quasi-periodically at the base of the flaring region and develop a three-dimensional MHD model of the event. For the initial state we utilize the dipole magnetic field to model the AR and include gravitationally stratified density at coronal temperature. At the coronal base of the AR, we excite the fast magnetosonic wave by periodic velocity pulsations in the photospheric plane confined to a funnel of magnetic field lines. The excited fast magnetosonic waves have similar amplitude, wavelength, and propagation speeds as the observed wave trains. Based on the simulation results, we discuss the possible excitation mechanism of the waves, their dynamical properties, and the use of the observations for coronal MHD seismology.

  13. PIC modeling of material dependence on fast electron generation and transport

    NASA Astrophysics Data System (ADS)

    Mishra, R.; Wei, M. S.; Chawla, S.; Sentoku, Y.; Stephens, R. B.; Beg, F. N.

    2011-10-01

    2D collisional PIC simulations, using PICLS code that includes dynamic ionization and radiation cooling, are performed to model a recent experiment on the Titan laser using multi-foil targets, where 2x reduction in total fast electron flux and a smaller spot size through high-Z layer were observed. Modeling show that a thin high-Z transport layer (e.g., Au) near lower Z source layer introduces a collimating effect on fast electron transport. Strong self-generated resistive B-fields are produced inside Au layer and at the interface (Al/Au), which confine the fast electron propagation and can also trap electrons in wing region to inhibit their propagation. In addition, effects of the surface material on LPI produced fast electron source characteristics are examined in both planar and buried cone geometries. Supported by US DOE under contracts DE-AC52 07NA27344(ACE) and DE-FC02-04ER54789 (FSC).

  14. Modeling of Single Noninactivating Na+ Channels: Evidence for Two Open and Several Fast Inactivated States

    PubMed Central

    The, Yu-Kai; Fernandes, Jacqueline; Popa, M. Oana; Alekov, Alexi K.; Timmer, Jens; Lerche, Holger

    2006-01-01

    Voltage-gated Na+ channels play a fundamental role in the excitability of nerve and muscle cells. Defects in fast Na+ channel inactivation can cause hereditary muscle diseases with hyper- or hypoexcitability of the sarcolemma. To explore the kinetics and gating mechanisms of noninactivating muscle Na+ channels on a molecular level, we analyzed single channel currents from wild-type and five mutant Na+ channels. The mutations were localized in different protein regions which have been previously shown to be important for fast inactivation (D3-D4-linker, D3/S4-S5, D4/S4-S5, D4/S6) and exhibited distinct grades of defective fast inactivation with varying levels of persistent Na+ currents caused by late channel reopenings. Different gating schemes were fitted to the data using hidden Markov models with a correction for time interval omission and compared statistically. For all investigated channels including the wild-type, two open states were necessary to describe our data. Whereas one inactivated state was sufficient to fit the single channel behavior of wild-type channels, modeling the mutants with impaired fast inactivation revealed evidence for several inactivated states. We propose a single gating scheme with two open and three inactivated states to describe the behavior of all five examined mutants. This scheme provides a biological interpretation of the collected data, based on previous investigations in voltage-gated Na+ and K+ channels. PMID:16513781

  15. Response of urinary hydroxyproline to dietary protein and fasting in white-tailed deer

    USGS Publications Warehouse

    DelGiudice, G.D.; Seal, U.S.; Mech, L.D.

    1988-01-01

    The effects of dietary protein, fasting, and refeeding on urinary hydroxyproline of nine captive female white-tailed deer (Odocoileus virginianus) were examined from 23 February to 3 May 1984 in northern Minnesota. In the fasted group, mean hydroxyproline:creatinine (OHP:C) was greater (P less than 0.05) at week 4 compared to baseline at week 0. Between fasted deer and deer fed high protein-high energy (HPHE) and low protein-high energy (LPHE) diets, no difference in OHP:C ratios was detected during the initial 4 wk of the study. Urinary OHP:C ratios were significantly (P less than 0.05) greater in the fasted group during refeeding, concomitant with greater feed consumption and weight gain. There was also a significant (P less than 0.02) time effect in the fasted-refed group; OHP:C ratios increased during these two phases of the study. There was no difference between the HPHE and LPHE fed deer in renal OHP excretion. However, mean OHP:C ratios in yearlings (16.8 +/- 2.2) were greater (P less than 0.001) than in the adults (7.5 +/- 1.2) of those groups, indicating a higher collagen turnover rate. Urinary OHP:C shows potential as an indicator of growth and starvation, and the data presented may serve as reference values.

  16. Physiological responses of juvenile rainbow trout to fasting and swimming activity: Effects on body composition and condition indices

    USGS Publications Warehouse

    Simpkins, D.G.; Hubert, W.A.; Del Rio, C.M.; Rule, D.C.

    2003-01-01

    The physiological traits that allow fish to survive periods of limited food resources are poorly understood. We assessed changes in proximate body composition, relative organ mass, blood metabolites, and relative weight (Wr) of sedentary and actively swimming (15 cm/s) juvenile rainbow trout (154-182 mm total length) over 147 d of fasting. Fasting caused measurable responses that were augmented when fish were swimming. Lipids and plasma triacylglycerides declined over time. Proteins were catabolized simultaneously with lipid reserves, but ammonia concentrations in plasma did not increase. The liver somatic index (LSI) did not change substantially over 105 d, suggesting that gluconeogenesis maintained blood glucose concentrations and hepatic glycogen reserves for a substantial period of fasting. The gut somatic index (GSI) and Wr declined linearly during fasting, but the LSI did not decline until after 105 d of fasting. Consequently, the use of different body condition indices could lead to different conclusions about the condition of juvenile rainbow trout. Swimming activity caused fish to have lower lipid and protein reserves than those of sedentary fish. No mortalities were observed among sedentary fish, but mortalities occurred among actively swimming fish after 97 d of fasting when 3.2% or less lipid remained in their bodies. Body condition indices did not account for differences in proximate body composition between sedentary and actively swimming fish and were relatively poor predictors of lipid content and risk of mortality. The probability of mortality was most accurately predicted by percent lipid content. Therefore, we suggest that fisheries scientists consider using percent lipid content when evaluating the physiological status and risk of mortality due to starvation among juvenile rainbow trout.

  17. Improvements to a Response Surface Thermal Model for Orion

    NASA Technical Reports Server (NTRS)

    Miller, Stephen W.; Walker, William Q.

    2011-01-01

    A study was performed to determine if a Design of Experiments (DOE)/Response Surface Methodology could be applied to on-orbit thermal analysis and produce a set of Response Surface Equations (RSE) that predict Orion vehicle temperatures within 10 F. The study used the Orion Outer Mold Line model. Five separate factors were identified for study: yaw, pitch, roll, beta angle, and the environmental parameters. Twenty-three external Orion components were selected and their minimum and maximum temperatures captured over a period of two orbits. Thus, there are 46 responses. A DOE case matrix of 145 runs was developed. The data from these cases were analyzed to produce a fifth order RSE for each of the temperature responses. For the 145 cases in the DOE matrix, the agreement between the engineering data and the RSE predictions was encouraging with 40 of the 46 RSEs predicting temperatures within the goal band. However, the verification cases showed most responses did not meet the 10 F goal. After reframing the focus of the study to better align the RSE development with the purposes of the model, a set of RSEs for both the minimum and maximum radiator temperatures was produced which predicted the engineering model output within +/-4 F. Therefore, with the correct application of the DOE/RSE methodology, RSEs can be developed that provide analysts a fast and easy way to screen large numbers of environments and assess proposed changes to the RSE factors.

  18. Quantifying Fast and Slow Responses of Terrestrial Carbon Exchange across a Water Availability Gradient in North American Flux Sites

    NASA Astrophysics Data System (ADS)

    Biederman, J. A.; Scott, R. L.; Goulden, M.

    2014-12-01

    Climate change is predicted to increase the frequency and severity of water limitation, altering terrestrial ecosystems and their carbon exchange with the atmosphere. Here we compare site-level temporal sensitivity of annual carbon fluxes to interannual variations in water availability against cross-site spatial patterns over a network of 19 eddy covariance flux sites. This network represents one order of magnitude in mean annual productivity and includes western North American desert shrublands and grasslands, savannahs, woodlands, and forests with continuous records of 4 to 12 years. Our analysis reveals site-specific patterns not identifiable in prior syntheses that pooled sites. We interpret temporal variability as an indicator of ecosystem response to annual water availability due to fast-changing factors such as leaf stomatal response and microbial activity, while cross-site spatial patterns are used to infer ecosystem adjustment to climatic water availability through slow-changing factors such as plant community and organic carbon pools. Using variance decomposition, we directly quantify how terrestrial carbon balance depends on slow- and fast-changing components of gross ecosystem production (GEP) and total ecosystem respiration (TER). Slow factors explain the majority of variance in annual net ecosystem production (NEP) across the dataset, and their relative importance is greater at wetter, forest sites than desert ecosystems. Site-specific offsets from spatial patterns of GEP and TER explain one third of NEP variance, likely due to slow-changing factors not directly linked to water, such as disturbance. TER and GEP are correlated across sites as previously shown, but our site-level analysis reveals surprisingly consistent linear relationships between these fluxes in deserts and savannahs, indicating fast coupling of TER and GEP in more arid ecosystems. Based on the uncertainty associated with slow and fast factors, we suggest a framework for improved

  19. Association of consecutive Pi2-Ps6 band pulsations with earthward fast flows in the plasma sheet in response to IMF variations

    NASA Astrophysics Data System (ADS)

    Cheng, Ching-Chang; Mann, Ian R.; Baumjohann, Wolfgang

    2014-05-01

    On 11 March 2009, the H component had four consecutive bay-like variations accompanied by positive and negative deflections in the D component across the Atlantic like those affected by the substorm current wedge formation. A train of pulsations with a frequency range 2-10 mHz (referred to as Pi2-Ps6 band), sensed by Time History of Events and Macroscale Interactions during Substorms (THEMIS)/Canadian Array for Real-time Investigations of Magnetic Activity (CARISMA) magnetometers, had clearly three consecutive Pi2s followed by a Ps6 at low latitudes, but first Pi2 and then Ps6 at high latitudes mixed with large-amplitude Ps6 at midlatitudes. The geostationary orbit magnetometers sensed similar magnetic perturbations. THEMIS probes first observed earthward fast flows, magnetic dipolarizations, and modulated energetic particle fluxes at ~ XGSM -9.2 RE, then at ~ XGSM -7.5 RE for Pi2 and at ~ XGSM -18.0 RE only for Ps6. They appeared during a very quiet period for northward interplanetary magnetic field (IMF) with a clock angle variation of low to high and then low. The H spectrum shows two harmonic frequencies ~2-4 mHz and ~8-10 mHz but the D spectrum one dominant frequency ~2-4 mHz. Pi2 can result from a combination of fast magnetospheric and plasmaspheric cavity resonances and Ps6 from a fast magnetospheric cavity resonance. The surface waves at the interface separating braking earthward fast flows from the ambient plasma convection region could lead to large-amplitude Ps6 at midlatitudes. Hence, consecutive Pi2-Ps6 band pulsations can be associated with earthward fast flows in the plasma sheet, expectedly driven by magnetotail reconnection, respectively, in the near-Earth region and the distant Earth one in response to IMF variations as in the two-neutral-point model.

  20. Scale-model characterization of flow-induced vibrational response of FFTF reactor internals

    SciTech Connect

    Ryan, J. A.; Mahoney, J. J.

    1980-10-01

    Fast Test Reactor core internal and peripheral components were assessed for flow-induced vibrational characteristics under scaled and simulated prototype flow conditions in the Hydraulic Core Mockup as an integral part of the Fast Test Reactor Vibration Program. The Hydraulic Core Mockup was an 0.285 geometric scale model of the Fast Test Reactor internals designed to simulate prototype vibrational and hydraulic characteristics. Using water to simulate sodium coolant, vibrational characteristics were measured and determined for selected model components over the scaled flow range of 36 to 110%. Additionally, in-situ shaker tests were conducted on selected Hydraulic Core Mockup outlet plenum components to establish modal characteristics. Most components exhibited resonant response at all test flow rates; however, the measured dynamic response was neither abnormal nor anomalously flow-rate dependent, and the predicted prototype components' response were deemed acceptable.

  1. Modeling of fast neutral-beam-generated ion effects on MHD-spectroscopic observations of resistive wall mode stability in DIII-D plasmas

    SciTech Connect

    Turco, F. Hanson, J. M.; Navratil, G. A.; Turnbull, A. D.

    2015-02-15

    Experiments conducted at DIII-D investigate the role of drift kinetic damping and fast neutral beam injection (NBI)-ions in the approach to the no-wall β{sub N} limit. Modelling results show that the drift kinetic effects are significant and necessary to reproduce the measured plasma response at the ideal no-wall limit. Fast neutral-beam ions and rotation play important roles and are crucial to quantitatively match the experiment. In this paper, we report on the model validation of a series of plasmas with increasing β{sub N}, where the plasma stability is probed by active magnetohydrodynamic (MHD) spectroscopy. The response of the plasma to an externally applied field is used to probe the stable side of the resistive wall mode and obtain an indication of the proximity of the equilibrium to an instability limit. We describe the comparison between the measured plasma response and that calculated by means of the drift kinetic MARS-K code [Liu et al., Phys. Plasmas 15, 112503 (2008)], which includes the toroidal rotation, the electron and ion drift-kinetic resonances, and the presence of fast particles for the modelled plasmas. The inclusion of kinetic effects allows the code to reproduce the experimental results within ∼13% for both the amplitude and phase of the plasma response, which is a significant improvement with respect to the undamped MHD-only model. The presence of fast NBI-generated ions is necessary to obtain the low response at the highest β{sub N} levels (∼90% of the ideal no-wall limit). The toroidal rotation has an impact on the results, and a sensitivity study shows that a large variation in the predicted response is caused by the details of the rotation profiles at high β{sub N}.

  2. The Creation of Surrogate Models for Fast Estimation of Complex Model Outcomes

    PubMed Central

    Pruett, W. Andrew; Hester, Robert L.

    2016-01-01

    A surrogate model is a black box model that reproduces the output of another more complex model at a single time point. This is to be distinguished from the method of surrogate data, used in time series. The purpose of a surrogate is to reduce the time necessary for a computation at the cost of rigor and generality. We describe a method of constructing surrogates in the form of support vector machine (SVM) regressions for the purpose of exploring the parameter space of physiological models. Our focus is on the methodology of surrogate creation and accuracy assessment in comparison to the original model. This is done in the context of a simulation of hemorrhage in one model, “Small”, and renal denervation in another, HumMod. In both cases, the surrogate predicts the drop in mean arterial pressure following the intervention. We asked three questions concerning surrogate models: (1) how many training examples are necessary to obtain an accurate surrogate, (2) is surrogate accuracy homogeneous, and (3) how much can computation time be reduced when using a surrogate. We found the minimum training set size that would guarantee maximal accuracy was widely variable, but could be algorithmically generated. The average error for the pressure response to the protocols was -0.05±2.47 in Small, and -0.3 +/- 3.94 mmHg in HumMod. In the Small model, error grew with actual pressure drop, and in HumMod, larger pressure drops were overestimated by the surrogates. Surrogate use resulted in a 6 order of magnitude decrease in computation time. These results suggest surrogate modeling is a valuable tool for generating predictions of an integrative model’s behavior on densely sampled subsets of its parameter space. PMID:27258010

  3. Spectrum response and analysis of 77 GHz band collective Thomson scattering diagnostic for bulk and fast ions in LHD plasmas

    NASA Astrophysics Data System (ADS)

    Nishiura, M.; Kubo, S.; Tanaka, K.; Seki, R.; Ogasawara, S.; Shimozuma, T.; Okada, K.; Kobayashi, S.; Mutoh, T.; Kawahata, K.; Watari, T.; LHD Experiment Group; Saito, T.; Tatematsu, Y.; Korsholm, S. B.; Salewski, M.

    2014-02-01

    A collective Thomson scattering (CTS) diagnostic was developed and used to measure the bulk and fast ions originating from 180 keV neutral beams in the Large Helical Device (LHD). Electromagnetic waves from a gyrotron at 77 GHz with 1 MW power output function as both the probe and electron cyclotron heating beam. To clarify the diagnostic applicability of the gyrotron in the 77 GHz frequency band, we investigated the dependence of the probe and receiver beam trajectories in plasmas with high electron densities of (4-5) × 1019 m-3 and low electron densities of (1-2) × 1019 m-3. At high density, a stray radiation component was observed in the CTS spectrum whereas it was negligibly small at low density. The CTS spectrum was measured and analysed after the in situ beam alignment using a beam scan. Qualitatively, the CTS spectrogram shows consistent response to ion temperatures of 1-2 keV for electron densities of (1-2) × 1019 m-3 and electron temperatures of 2-4 keV. The measured CTS spectrum shows an asymmetric shape at the foot of the bulk-ion region during the injection of 180 keV fast ions. This shape is explained by the fast-ion distribution in the velocity space (v‖, v⊥) based on Monte Carlo simulation results. The analysis method of the CTS spectra is used to evaluate the ion temperature and fast-ion velocity distribution from the measured CTS data.

  4. Fasting levels of ghrelin covary with the brain response to food pictures.

    PubMed

    Kroemer, Nils B; Krebs, Lena; Kobiella, Andrea; Grimm, Oliver; Pilhatsch, Maximilian; Bidlingmaier, Martin; Zimmermann, Ulrich S; Smolka, Michael N

    2013-09-01

    Ghrelin figures prominently in the regulation of appetite in normal-weighed individuals. The apparent failure of this mechanism in eating disorders and the connection to addictive behavior in general demand a deeper understanding of the endogenous central-nervous processes related to ghrelin. Thus, we investigated processing of pictures showing palatable food after overnight fasting and following a standardized caloric intake (i.e. a 75-g oral glucose tolerance test) using functional magnetic resonance imaging and correlated it with blood plasma levels of ghrelin. Twenty-six healthy female and male volunteers viewed food and control pictures in a block design and rated their appetite after each block. Fasting levels of ghrelin correlated positively with food-cue reactivity in a bilateral network of visual processing-, reward- and taste-related regions, including limbic and paralimbic regions. Notably, among those regions were the hypothalamus and the midbrain where ghrelin receptors are densely concentrated. In addition, high fasting ghrelin levels were associated with stronger increases of subjective appetite during the food-cue-reactivity task. In conclusion, brain activation and subjective appetite ratings suggest that ghrelin elevates the hedonic effects of food pictures. Thereby, fasting ghrelin levels may generally enhance subjective craving when confronted with reward cues.

  5. Predicting Student Responsiveness to Fast ForWord Using DIBELS Subtests

    ERIC Educational Resources Information Center

    Cavallo, Fernando

    2012-01-01

    The current study was completed through a retrospective analysis of school records of elementary school students in the Northeast Region of the Philadelphia School District (PSD) who have participated in the Fast ForWord (FFW) Language program. The data requested from student records included: demographic information (e.g., gender, grade, age,…

  6. Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics.

    PubMed

    Helassa, Nordine; Zhang, Xiao-hua; Conte, Ianina; Scaringi, John; Esposito, Elric; Bradley, Jonathan; Carter, Thomas; Ogden, David; Morad, Martin; Török, Katalin

    2015-11-03

    Faithful reporting of temporal patterns of intracellular Ca(2+) dynamics requires the working range of indicators to match the signals. Current genetically encoded calmodulin-based fluorescent indicators are likely to distort fast Ca(2+) signals by apparent saturation and integration due to their limiting fluorescence rise and decay kinetics. A series of probes was engineered with a range of Ca(2+) affinities and accelerated kinetics by weakening the Ca(2+)-calmodulin-peptide interactions. At 37 °C, the GCaMP3-derived probe termed GCaMP3fast is 40-fold faster than GCaMP3 with Ca(2+) decay and rise times, t1/2, of 3.3 ms and 0.9 ms, respectively, making it the fastest to-date. GCaMP3fast revealed discreet transients with significantly faster Ca(2+) dynamics in neonatal cardiac myocytes than GCaMP6f. With 5-fold increased two-photon fluorescence cross-section for Ca(2+) at 940 nm, GCaMP3fast is suitable for deep tissue studies. The green fluorescent protein serves as a reporter providing important novel insights into the kinetic mechanism of target recognition by calmodulin. Our strategy to match the probe to the signal by tuning the affinity and hence the Ca(2+) kinetics of the indicator is applicable to the emerging new generations of calmodulin-based probes.

  7. Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics

    PubMed Central

    Helassa, Nordine; Zhang, Xiao-hua; Conte, Ianina; Scaringi, John; Esposito, Elric; Bradley, Jonathan; Carter, Thomas; Ogden, David; Morad, Martin; Török, Katalin

    2015-01-01

    Faithful reporting of temporal patterns of intracellular Ca2+ dynamics requires the working range of indicators to match the signals. Current genetically encoded calmodulin-based fluorescent indicators are likely to distort fast Ca2+ signals by apparent saturation and integration due to their limiting fluorescence rise and decay kinetics. A series of probes was engineered with a range of Ca2+ affinities and accelerated kinetics by weakening the Ca2+-calmodulin-peptide interactions. At 37 °C, the GCaMP3-derived probe termed GCaMP3fast is 40-fold faster than GCaMP3 with Ca2+ decay and rise times, t1/2, of 3.3 ms and 0.9 ms, respectively, making it the fastest to-date. GCaMP3fast revealed discreet transients with significantly faster Ca2+ dynamics in neonatal cardiac myocytes than GCaMP6f. With 5-fold increased two-photon fluorescence cross-section for Ca2+ at 940 nm, GCaMP3fast is suitable for deep tissue studies. The green fluorescent protein serves as a reporter providing important novel insights into the kinetic mechanism of target recognition by calmodulin. Our strategy to match the probe to the signal by tuning the affinity and hence the Ca2+ kinetics of the indicator is applicable to the emerging new generations of calmodulin-based probes. PMID:26527405

  8. Modeling of fast wave absorption by beam ions in DIII-D discharges

    SciTech Connect

    Mau, T. K.; Petty, C. C.; Porkolab, M.; Heidbrink, W. W.

    1999-09-20

    In recent discharges on DIII-D, neutron measurements indicated absorption of the fast wave by energetic deuterium beam ions when the fourth harmonic resonance is on axis, but little or no interaction for the fifth harmonic. In this work, a geometric optics code is used to quantify the beam ion absorption of fast waves as the frequency (or on-axis harmonic resonance) is varied. Isotropic and anisotropic Maxwellians are used to model the beam ion distribution. Wave power flow in this harmonic range has been found to exhibit a strong poloidal and toroidal behavior in its initial transits across the plasma. Absorption along the rays is calculated using the fully thermal and magnetized treatment. Competing with the beam ions for absorption are the minority hydrogen and background electrons. The modeling results are only in partial agreement with experimental observations, indicating that more detailed physics may need to be included. (c) 1999 American Institute of Physics.

  9. The use of kinetic modelling as a fast way to screen thermal endurance of space materials

    NASA Astrophysics Data System (ADS)

    Moser, M.; Heltzel, S.; Semprimoschnig, C.; Garcia Martin, G.

    2003-09-01

    Currently planned missions of ESA (European Space Agency) to the inner part of the solar system will require the use of materials at an extreme radiation and temperature environment. A major concern regarding the selection of these materials is the thermal behaviour and the thermal stability. In this paper two kinetic models, the one following the ASTM E 1641 and ASTM E 1877 standards and the other following the Model Free Kinetics (MFK) approach, are presented. These models allow an easy and fast way to screen the thermal endurance of organic materials by running Thermo Gravimetric Analyses (TGA) temperature scans.

  10. A fast all-sky radiative transfer model and its implications for solar energy research

    NASA Astrophysics Data System (ADS)

    Xie, Y.; Sengupta, M.

    2015-12-01

    Radiative transfer models simulating broadband solar radiation, e.g. Rapid Radiation Transfer Model (RRTM) and its GCM applications, have been widely used by atmospheric scientists to model solar resource for various energy applications such as operational forecasting. Due to the complexity of solving the radiative transfer equation, simulating solar radiation under cloudy conditions can be extremely time consuming though many approximations, e.g. two-stream approach and delta-M truncation scheme, have been utilized. To provide a new option to approximate solar radiation, we developed a Fast All-sky Radiation Model for Solar applications (FARMS) using simulated cloud transmittance and reflectance from 16-stream RRTM model runs. The solar irradiances at the land surface were simulated by combining parameterized cloud properties with a fast clear-sky radiative transfer model. Using solar radiation measurements from the US Department of Energy's Atmospheric Radiation Measurement (ARM) central facility in Oklahoma as a benchmark against the model simulations, we were able to demonstrate that the accuracy of FARMS was comparable to the two-stream approach. However, FARMS is much more efficient since it does not explicitly solve the radiative transfer equation for each individual cloud condition. We further explored the use of FARMS to promote solar resource assessment and forecasting research through the increased ability to accommodate higher spatial and temporal resolution calculations for the next generation of satellite and numerical weather prediction (NWP) models.

  11. Fasting and refeeding: cell kinetic response of jejunum, ileum and colon.

    PubMed

    Hagemann, R F; Stragand, J J

    1977-01-01

    Following a period of fasting, feeding a normal diet results in a burst of DNA synthesis in the crypts of the colonic epithelium. This is due largely to a prompt entry of cells, blocked in G1, into S. Peak levels of S cellularity exceed 4 times the fasting, and 2 times the normal fed control values. Refeeding a low residue diet (soluble casien, glucose and corn oil) results in a return to control levels of proliferative activity, but no hyperplasia. However, in jejunum and ileum, refeeding is followed by a return to near control levels of proliferation with only a slight overshoot in S phase cellularity. During the fasting period, the ileal crypt proliferative compartment (Pc-zone) and total crypt cellularity decline significantly. These changes are accompanied by an increase in the total cycle time, due to an equivalent lengthening of the G1 and S phase. Following refeeding, there is a reduction in the cycle time and a gradual return to the control values for the Pc-zone size and cellularity. In the colon, fasting has no effect on the Pc-zone size or total crypt cellularity. There is an approximate doubling of the cycle time due solely to an increase in G1. Following refeeding there is an increase in the Pc-zone size and crypt cellularity and a marked shortening of the cycle time. Evidence that a G1 cycle blockade is induced in the colon by fasting is given by a lenghening of the G1 period and by stathmokinetic studies employing vincristine.

  12. FAST: A Fuel And Sheath Modeling Tool for CANDU Reactor Fuel

    NASA Astrophysics Data System (ADS)

    Prudil, Andrew Albert

    Understanding the behaviour of nuclear fuel during irradiation is a complicated multiphysics problem involving neutronics, chemistry, radiation physics, material-science, solid mechanics, heat transfer and thermal-hydraulics. Due to the complexity and interdependence of the physics and models involved, fuel modeling is typically clone with numerical models. Advancements in both computer hardware and software have made possible new more complex and sophisticated fuel modeling codes. The Fuel And Sheath modelling Tool (FAST) is a fuel performance code that has been developed for modeling nuclear fuel behaviour under normal and transient conditions. The FAST code includes models for heat generation and transport, thermal expansion, elastic strain, densification, fission product swelling, pellet relocation, contact, grain growth, fission gas release, gas and coolant pressure and sheath creep. These models are coupled and solved numerically using the Comsol Multiphysics finite-element platform. The model utilizes a radialaxial geometry of a fuel pellet (including dishing and chamfering) and accompanying fuel sheath allowing the model to predict circumferential ridging. This model has evolved from previous treatments developed at the Royal Military College. The model has now been significantly advanced to include: a more detailed pellet geometry, localized pellet-to-sheath gap size and contact pressure, ability to model cracked pellets, localized fuel burnup for material property models, improved U02 densification behaviour, fully 2-dimensional model for the sheath, additional creep models, additional material models, an FEM Booth-diffusion model for fission gas release (including ability to model temperature and power changes), a capability for end-of-life predictions, the ability to utilize text files as model inputs, and provides a first time integration of normal operating conditions (NOC) and transient fuel models into a single code (which has never been achieved

  13. An Optimal Control Modification to Model-Reference Adaptive Control for Fast Adaptation

    NASA Technical Reports Server (NTRS)

    Nguyen, Nhan T.; Krishnakumar, Kalmanje; Boskovic, Jovan

    2008-01-01

    This paper presents a method that can achieve fast adaptation for a class of model-reference adaptive control. It is well-known that standard model-reference adaptive control exhibits high-gain control behaviors when a large adaptive gain is used to achieve fast adaptation in order to reduce tracking error rapidly. High gain control creates high-frequency oscillations that can excite unmodeled dynamics and can lead to instability. The fast adaptation approach is based on the minimization of the squares of the tracking error, which is formulated as an optimal control problem. The necessary condition of optimality is used to derive an adaptive law using the gradient method. This adaptive law is shown to result in uniform boundedness of the tracking error by means of the Lyapunov s direct method. Furthermore, this adaptive law allows a large adaptive gain to be used without causing undesired high-gain control effects. The method is shown to be more robust than standard model-reference adaptive control. Simulations demonstrate the effectiveness of the proposed method.

  14. A Unidimensional Item Response Model for Unfolding Responses from a Graded Disagree-Agree Response Scale.

    ERIC Educational Resources Information Center

    Roberts, James S.; Laughlin, James E.

    1996-01-01

    A parametric item response theory model for unfolding binary or graded responses is developed. The graded unfolding model (GUM) is a generalization of the hyperbolic cosine model for binary data of D. Andrich and G. Luo (1993). Applicability of the GUM to attitude testing is illustrated with real data. (SLD)

  15. A mixture hierarchical model for response times and response accuracy.

    PubMed

    Wang, Chun; Xu, Gongjun

    2015-11-01

    In real testing, examinees may manifest different types of test-taking behaviours. In this paper we focus on two types that appear to be among the more frequently occurring behaviours – solution behaviour and rapid guessing behaviour. Rapid guessing usually happens in high-stakes tests when there is insufficient time, and in low-stakes tests when there is lack of effort. These two qualitatively different test-taking behaviours, if ignored, will lead to violation of the local independence assumption and, as a result, yield biased item/person parameter estimation. We propose a mixture hierarchical model to account for differences among item responses and response time patterns arising from these two behaviours. The model is also able to identify the specific behaviour an examinee engages in when answering an item. A Monte Carlo expectation maximization algorithm is proposed for model calibration. A simulation study shows that the new model yields more accurate item and person parameter estimates than a non-mixture model when the data indeed come from two types of behaviour. The model also fits real, high-stakes test data better than a non-mixture model, and therefore the new model can better identify the underlying test-taking behaviour an examinee engages in on a certain item. PMID:25873487

  16. Development of models for fast fluid pathways through unsaturated heterogeneous porous media

    SciTech Connect

    Robey, T.H.

    1994-11-01

    The pre-waste-emplacement ground water travel time requirement is a regulatory criterion that specifies ground water travel time to the accessible environment shall be greater than 1,000 years. Satisfying the ground water travel time criterion for the potential repository at Yucca Mountain requires the study of fast travel path formation in the unsaturated zone and development of models that simulate the formation of fast paths. Conceptual models for unsaturated flow that have been used for total-systems performance assessment generally fall into the categories of composite-porosity or fracture models. The actual hydrologic conditions at Yucca Mountain are thought to lie somewhere between the extremes of these two types of models. The current study considers the effects of heterogeneities on composite-porosity models and seeks to develop numerical methods (and models) that can produce locally saturated zones where fracture flow can occur. The credibility of the model and numerical methods is investigated by using test data from the INTRAVAL project (Swedish Nuclear Inspectorate, 1992) to attempt to predict in-situ volumetric water content at specific locations in Yucca Mountain. Work based on the numerical methods presented in this study is eventually intended to allow the calculation of ground water travel times in heterogeneous media. 60 refs.

  17. A Quasiphysics Intelligent Model for a Long Range Fast Tool Servo

    PubMed Central

    Liu, Qiang; Zhou, Xiaoqin; Lin, Jieqiong; Xu, Pengzi; Zhu, Zhiwei

    2013-01-01

    Accurately modeling the dynamic behaviors of fast tool servo (FTS) is one of the key issues in the ultraprecision positioning of the cutting tool. Herein, a quasiphysics intelligent model (QPIM) integrating a linear physics model (LPM) and a radial basis function (RBF) based neural model (NM) is developed to accurately describe the dynamic behaviors of a voice coil motor (VCM) actuated long range fast tool servo (LFTS). To identify the parameters of the LPM, a novel Opposition-based Self-adaptive Replacement Differential Evolution (OSaRDE) algorithm is proposed which has been proved to have a faster convergence mechanism without compromising with the quality of solution and outperform than similar evolution algorithms taken for consideration. The modeling errors of the LPM and the QPIM are investigated by experiments. The modeling error of the LPM presents an obvious trend component which is about ±1.15% of the full span range verifying the efficiency of the proposed OSaRDE algorithm for system identification. As for the QPIM, the trend component in the residual error of LPM can be well suppressed, and the error of the QPIM maintains noise level. All the results verify the efficiency and superiority of the proposed modeling and identification approaches. PMID:24163627

  18. Ultra-fast Microwave Synthesis of ZnO Nanowires and their Dynamic Response Toward Hydrogen Gas.

    PubMed

    Qurashi, Ahsanulhaq; Tabet, N; Faiz, M; Yamzaki, Toshinari

    2009-04-25

    Ultra-fast and large-quantity (grams) synthesis of one-dimensional ZnO nanowires has been carried out by a novel microwave-assisted method. High purity Zinc (Zn) metal was used as source material and placed on microwave absorber. The evaporation/oxidation process occurs under exposure to microwave in less than 100 s. Field effect scanning electron microscopy analysis reveals the formation of high aspect-ratio and high density ZnO nanowires with diameter ranging from 70 to 80 nm. Comprehensive structural analysis showed that these ZnO nanowires are single crystal in nature with excellent crystal quality. The gas sensor made of these ZnO nanowires exhibited excellent sensitivity, fast response, and good reproducibility. Furthermore, the method can be extended for the synthesis of other oxide nanowires that will be the building block of future nanoscale devices.

  19. Fast and non-invasive conductivity determination by the dielectric response of reduced graphene oxide: an electrostatic force microscopy study.

    PubMed

    Gómez-Navarro, Cristina; Guzmán-Vázquez, Francisco J; Gómez-Herrero, Julio; Saenz, Juan J; Sacha, G M

    2012-11-21

    The high dispersion found in the literature for the conductivity of Reduced Graphene Oxide (RGO) layers makes it highly desirable to develop fast and non-invasive methods for their characterization. Here we show that Electrostatic Force Microscopy (EFM) is an in situ, fast, and contactless technique to evaluate the conductivity of chemically derived graphene layers. The dielectric response of RGO flakes is observed to depend on their conductivity in the range of 0-3 S m(-1). Interestingly, we also find that for electrostatic purposes, a graphene layer is equivalent to an extremely thin dielectric layer with an effective permittivity (ε(eff)) that depends on the conductivity of the layers and spans from 5 for the insulating layers, to 2000 for the more conductive ones. We discuss how these high values of ε(eff) are a consequence of the incomplete screening of electric fields through graphene layers.

  20. Mathematical model and its fast numerical method for the tumor growth.

    PubMed

    Lee, Hyun Geun; Kim, Yangjin; Kim, Junseok

    2015-12-01

    In this paper, we reformulate the diffuse interface model of the tumor growth (S.M. Wise et al., Three-dimensional multispecies nonlinear tumor growth-I: model and numerical method, J. Theor. Biol. 253 (2008) 524--543). In the new proposed model, we use the conservative second-order Allen--Cahn equation with a space--time dependent Lagrange multiplier instead of using the fourth-order Cahn--Hilliard equation in the original model. To numerically solve the new model, we apply a recently developed hybrid numerical method. We perform various numerical experiments. The computational results demonstrate that the new model is not only fast but also has a good feature such as distributing excess mass from the inside of tumor to its boundary regions. PMID:26775855

  1. Demanding response time requirements on coherent receivers due to fast polarization rotations caused by lightning events.

    PubMed

    Krummrich, Peter M; Ronnenberg, David; Schairer, Wolfgang; Wienold, Daniel; Jenau, Frank; Herrmann, Maximilian

    2016-05-30

    Lightning events can cause fast polarization rotations and phase changes in optical transmission fibers due to strong electrical currents and magnetic fields. Whereas these are unlikely to affect legacy transmission systems with direct detection, different mechanisms have to be considered in systems with local oscillator based coherent receivers and digital signal processing. A theoretical analysis reveals that lightning events can result in polarization rotations with speeds as fast as a few hundred kRad/s. We discuss possible mechanisms how such lightning events can affect coherent receivers with digital signal processing. In experimental investigations with a high current pulse generator and transponder prototypes, we observed post FEC errors after polarization rotation events which can be expected from lightning strikes. PMID:27410158

  2. Demanding response time requirements on coherent receivers due to fast polarization rotations caused by lightning events.

    PubMed

    Krummrich, Peter M; Ronnenberg, David; Schairer, Wolfgang; Wienold, Daniel; Jenau, Frank; Herrmann, Maximilian

    2016-05-30

    Lightning events can cause fast polarization rotations and phase changes in optical transmission fibers due to strong electrical currents and magnetic fields. Whereas these are unlikely to affect legacy transmission systems with direct detection, different mechanisms have to be considered in systems with local oscillator based coherent receivers and digital signal processing. A theoretical analysis reveals that lightning events can result in polarization rotations with speeds as fast as a few hundred kRad/s. We discuss possible mechanisms how such lightning events can affect coherent receivers with digital signal processing. In experimental investigations with a high current pulse generator and transponder prototypes, we observed post FEC errors after polarization rotation events which can be expected from lightning strikes.

  3. Graded Response Model Based on the Logistic Positive Exponent Family of Models for Dichotomous Responses

    ERIC Educational Resources Information Center

    Samejima, Fumiko

    2008-01-01

    Samejima ("Psychometrika "65:319--335, 2000) proposed the logistic positive exponent family of models (LPEF) for dichotomous responses in the unidimensional latent space. The objective of the present paper is to propose and discuss a graded response model that is expanded from the LPEF, in the context of item response theory (IRT). This specific…

  4. Prediction of Sawtooth Periods in Fast-Wave Heated DIII-D Experiments Using Extensions of the Porcelli Model

    NASA Astrophysics Data System (ADS)

    Turnbull, A. D.; Choi, M.; Lao, L. L.; Chan, V. S.; Chu, M. S.; Jeon, Y. M.; Li, G.; Ren, Q.; Gorelenkov, N.

    2007-11-01

    Validation of a predictive sawtooth model is important for burning plasma experiments such as ITER. The Porcelli model using simplified expressions for the key contributions has been found to predict average sawtooth periods reasonably well in existing tokamaks. We evaluate this model using realistic models for the ideal MHD contribution from GATO, and a nonisotropic fast ion contribution using ORBIT-RF and TORIC for the rf-modified fast-ion pressure. Application to the first giant sawtooth cycle in a DIII-D discharge where beam ions accelerated by fast waves modify the sawteeth shows the model can predict the crash time consistent with the experimental crash. The stabilizing contributions depend strongly on uncertainties in the magnetic shear at q=1 and the fast ion poloidal beta. The model will be also applied to other sawteeth in the same discharge and compared to predictions from the more complete NOVA-K stability code with full anistropy.

  5. Modeling T cell responses to antigenic challenge

    PubMed Central

    Wodarz, Dominik

    2014-01-01

    T cell responses are a crucial part of the adaptive immune system in the fight against infections. This article discusses the use of mathematical models for understanding the dynamics of cytotoxic T lymphocyte (CTL) responses against viral infections. Complementing experimental research, mathematical models have been very useful for exploring new hypotheses, interpreting experimental data, and for defining what needs to be measured to improve understanding. This review will start with minimally parameterized models of CTL responses, which have generated some valuable insights into basic dynamics and correlates of control. Subsequently, more biological complexity is incorporated into this modeling framework, examining different mechanisms of CTL expansion, different effector activities, and the influence of T cell help. Models and results are discussed in the context of data from specific infections. PMID:25269610

  6. Modeling of the fast organic emissions from a wood-finishing product—Floor wax

    NASA Astrophysics Data System (ADS)

    Chang, John C. S.; Guo, Zhishi

    Environmental chamber and full-scale residential house tests were conducted to evaluate the fast organic emissions from a wood-finishing product—floor wax. For the environmental chamber tests, a very small amount of (<5 gm -2) of the wax was applied to an aluminum plate. It was found that the chamber exit organic concentrations can be estimated by a model with an initial condition of instant organic emissions. The model was applied to the house data to interpret the octane and nonane emissions. Significant sink effects were found in the house that prolonged the elevated octane and nonane concentrations for more than 2 days.

  7. Taxonomy for Modeling Demand Response Resources

    SciTech Connect

    Olsen, Daniel; Kiliccote, Sila; Sohn, Michael; Dunn, Laura; Piette, Mary, A

    2014-08-01

    Demand response resources are an important component of modern grid management strategies. Accurate characterizations of DR resources are needed to develop systems of optimally managed grid operations and to plan future investments in generation, transmission, and distribution. The DOE Demand Response and Energy Storage Integration Study (DRESIS) project researched the degree to which demand response (DR) and energy storage can provide grid flexibility and stability in the Western Interconnection. In this work, DR resources were integrated with traditional generators in grid forecasting tools, specifically a production cost model of the Western Interconnection. As part of this study, LBNL developed a modeling framework for characterizing resource availability and response attributes of DR resources consistent with the governing architecture of the simulation modeling platform. In this report, we identify and describe the following response attributes required to accurately characterize DR resources: allowable response frequency, maximum response duration, minimum time needed to achieve load changes, necessary pre- or re-charging of integrated energy storage, costs of enablement, magnitude of controlled resources, and alignment of availability. We describe a framework for modeling these response attributes, and apply this framework to characterize 13 DR resources including residential, commercial, and industrial end-uses. We group these end-uses into three broad categories based on their response capabilities, and define a taxonomy for classifying DR resources within these categories. The three categories of resources exhibit different capabilities and differ in value to the grid. Results from the production cost model of the Western Interconnection illustrate that minor differences in resource attributes can have significant impact on grid utilization of DR resources. The implications of these findings will be explored in future DR valuation studies.

  8. Modeling of low- and high-frequency noise by slow and fast fluctuators

    NASA Astrophysics Data System (ADS)

    Nesterov, Alexander I.; Berman, Gennady P.

    2012-05-01

    We study the dynamics of dephasing in a quantum two-level system by modeling both 1/f and high-frequency noise by random telegraph processes. Our approach is based on a so-called spin-fluctuator model in which a noisy environment is modeled by a large number of fluctuators. In the continuous limit we obtain an effective random process (ERP) that is described by a distribution function of the fluctuators. In a simplified model, we reduce the ERP to the two (slow and fast) ensembles of fluctuators. Using this model, we study decoherence in a superconducting flux qubit and we compare our theoretical results with the available experimental data. We demonstrate good agreement of our theoretical predictions with the experiments. Our approach can be applied to many quantum systems, such as biological complexes, semiconductors, superconducting, and spin qubits, where the effects of interaction with the environment are essential.

  9. Composite model of microstructural evolution in austenitic stainless steel under fast neutron irradiation

    SciTech Connect

    Stoller, R.E.; Odette, G.R.

    1986-01-01

    A rate-theory-based model has been developed which includes the simultaneous evolution of the dislocation and cavity components of the microstructure of irradiated austenitic stainless steels. Previous work has generally focused on developing models for void swelling while neglecting the time dependence of the dislocation structure. These models have broadened our understanding of the physical processes that give rise to swelling, e.g., the role of helium and void formation from critically-sized bubbles. That work has also demonstrated some predictive capability by successful calibration to fit the results of fast reactor swelling data. However, considerable uncertainty about the values of key parameters in these models limits their usefulness as predictive tools. Hence the use of such models to extrapolate fission reactor swelling data to fusion reactor conditions is compromised.

  10. Motion-deblurred, fast-response pressure-sensitive paint on a rotor in forward flight

    NASA Astrophysics Data System (ADS)

    Juliano, Thomas J.; Disotell, Kevin J.; Gregory, James W.; Crafton, Jim; Fonov, Sergey

    2012-04-01

    A pressure-sensitive paint (PSP) system capable of measuring the global, unsteady pressure distribution on a rotating surface without resorting to phase averaging is applied to a two-bladed model propeller in edgewise freestream flow. A gated lifetime-based technique captures the paint luminescence after a single pulse of high-energy laser excitation, yielding a signal-to-noise ratio sufficient to avoid image averaging. The selection of a porous polymer/ceramic matrix base with platinum tetra(pentafluorophenyl) porphyrin (PtTFPP) as the luminophore afforded high frequency response and pressure sensitivity, but the long lifetime of PtTFPP caused blurring in the long-exposure image of the rotating blade. An approach to deblurring based on the lifetime of the paint and surface motion is described and validated by results obtained from a disc of 17.8 cm diameter spinning at 70 Hz. An infrared camera recorded wind-on and -off temperature maps to provide a temperature correction for the PSP. The single-shot PSP technique with motion deblurring and temperature correction is then applied to a vertically mounted model propeller with a 25.4 cm diameter and 10.2 cm pitch. Surface pressure maps for the advancing and retreating blades are presented for a spin rate of 70 Hz and advance ratio of 0.3. The higher suction peak and other features on the advancing blade due to its larger effective velocity are detected by the paint system, while the retreating blade shows a qualitatively different distribution.

  11. Experimental study of unsteady aerothermodynamic phenomena on shock-tube wall using fast-response temperature-sensitive paints

    NASA Astrophysics Data System (ADS)

    Ozawa, Hiroshi

    2016-04-01

    This paper describes an experimental study that used a fast-response temperature-sensitive paint (TSP) to investigate the unsteady aerothermodynamic phenomena occurring on a shock-tube wall. To understand these phenomena in detail, a fast-response TSP with high temperature sensitivity developed for transient temperature measurement was applied to the wall. The shock-tube experiment was carried out under the over-tailored condition, with a pressure ratio of 110 for test gases of air in driver/driven tubes. The following aspects were clarified using the TSP: (a) the TSP could be used to visualize the unsteady aerothermodynamic phenomena and estimate the quantitative heat flux on the shock-tube wall; (b) an x-t diagram based on the TSP response showed shock-tube wall characteristics that included the incident/reflected shocks, laminar-to-turbulent boundary-layer transition, streaks in the turbulent boundary layer, reflected shock/turbulent boundary layer interaction, and waves reflected from a contact surface; (c) the TSP graphically showed that a transition front from the plate's leading edge and turbulent spots moved with 80% of the free-stream velocity behind the incident shock. In addition, the TSP could track the growth of the turbulent spots on the wall.

  12. Exposure–Response Modeling of Clinical End Points Using Latent Variable Indirect Response Models

    PubMed Central

    Hu, C

    2014-01-01

    Exposure–response modeling facilitates effective dosing regimen selection in clinical drug development, where the end points are often disease scores and not physiological variables. Appropriate models need to be consistent with pharmacology and identifiable from the time courses of available data. This article describes a general framework of applying mechanism-based models to various types of clinical end points. Placebo and drug model parameterization, interpretation, and assessment are discussed with a focus on the indirect response models. PMID:24897307

  13. Experimental model updating using frequency response functions

    NASA Astrophysics Data System (ADS)

    Hong, Yu; Liu, Xi; Dong, Xinjun; Wang, Yang; Pu, Qianhui

    2016-04-01

    In order to obtain a finite element (FE) model that can more accurately describe structural behaviors, experimental data measured from the actual structure can be used to update the FE model. The process is known as FE model updating. In this paper, a frequency response function (FRF)-based model updating approach is presented. The approach attempts to minimize the difference between analytical and experimental FRFs, while the experimental FRFs are calculated using simultaneously measured dynamic excitation and corresponding structural responses. In this study, the FRF-based model updating method is validated through laboratory experiments on a four-story shear-frame structure. To obtain the experimental FRFs, shake table tests and impact hammer tests are performed. The FRF-based model updating method is shown to successfully update the stiffness, mass and damping parameters of the four-story structure, so that the analytical and experimental FRFs match well with each other.

  14. Fast Response and High Sensitivity ZnO/glass Surface Acoustic Wave Humidity Sensors Using Graphene Oxide Sensing Layer

    PubMed Central

    Xuan, Weipeng; He, Mei; Meng, Nan; He, Xingli; Wang, Wenbo; Chen, Jinkai; Shi, Tianjin; Hasan, Tawfique; Xu, Zhen; Xu, Yang; Luo, J. K.

    2014-01-01

    We report ZnO/glass surface acoustic wave (SAW) humidity sensors with high sensitivity and fast response using graphene oxide sensing layer. The frequency shift of the sensors is exponentially correlated to the humidity change, induced mainly by mass loading effect rather than the complex impedance change of the sensing layer. The SAW sensors show high sensitivity at a broad humidity range from 0.5%RH to 85%RH with < 1 sec rise time. The simple design and excellent stability of our GO-based SAW humidity sensors, complemented with full humidity range measurement, highlights their potential in a wide range of applications. PMID:25425458

  15. Measurement of N{sub 2}O fluxes from fertilized grassland using a fast response tunable diode laser spectrometer

    SciTech Connect

    Wienhold, F.G.; Frahm, H.; Harris, G.W.

    1994-08-20

    Measurements of nitrous oxide flux from fertilized agricultural grasslands is important in explaining and predicting the relationship of emissions of this gas to global warming. The nitrous oxide flux from agricultural grasslands was measured using micrometeorological techniques at a site near Stirling, Scotland. Emission levels were measured using a fast response tunable diode laser spectrometer. Measurements were made by both eddy correlation and concentration gradient techniques. This paper describes the results of this experiment and discusses information obtained that may be used for the characterization of the spatial variability in nitrous oxide emissions. 20 refs., 8 figs, 1 tab.

  16. Capabilities of a Global 3D MHD Model for Monitoring Extremely Fast CMEs

    NASA Astrophysics Data System (ADS)

    Wu, C. C.; Plunkett, S. P.; Liou, K.; Socker, D. G.; Wu, S. T.; Wang, Y. M.

    2015-12-01

    Since the start of the space era, spacecraft have recorded many extremely fast coronal mass ejections (CMEs) which have resulted in severe geomagnetic storms. Accurate and timely forecasting of the space weather effects of these events is important for protecting expensive space assets and astronauts and avoiding communications interruptions. Here, we will introduce a newly developed global, three-dimensional (3D) magnetohydrodynamic (MHD) model (G3DMHD). The model takes the solar magnetic field maps at 2.5 solar radii (Rs) and intepolates the solar wind plasma and field out to 18 Rs using the algorithm of Wang and Sheeley (1990, JGR). The output is used as the inner boundary condition for a 3D MHD model. The G3DMHD model is capable of simulating (i) extremely fast CME events with propagation speeds faster than 2500 km/s; and (ii) multiple CME events in sequence or simultaneously. We will demonstrate the simulation results (and comparison with in-situ observation) for the fastest CME in record on 23 July 2012, the shortest transit time in March 1976, and the well-known historic Carrington 1859 event.

  17. Fast modeling of flux trapping cascaded explosively driven magnetic flux compression generators

    NASA Astrophysics Data System (ADS)

    Wang, Yuwei; Zhang, Jiande; Chen, Dongqun; Cao, Shengguang; Li, Da; Liu, Chebo

    2013-01-01

    To predict the performance of flux trapping cascaded flux compression generators, a calculation model based on an equivalent circuit is investigated. The system circuit is analyzed according to its operation characteristics in different steps. Flux conservation coefficients are added to the driving terms of circuit differential equations to account for intrinsic flux losses. To calculate the currents in the circuit by solving the circuit equations, a simple zero-dimensional model is used to calculate the time-varying inductance and dc resistance of the generator. Then a fast computer code is programmed based on this calculation model. As an example, a two-staged flux trapping generator is simulated by using this computer code. Good agreements are achieved by comparing the simulation results with the measurements. Furthermore, it is obvious that this fast calculation model can be easily applied to predict performances of other flux trapping cascaded flux compression generators with complex structures such as conical stator or conical armature sections and so on for design purpose.

  18. Mobilization of mercury from lean tissues during simulated migratory fasting in a model songbird.

    PubMed

    Seewagen, Chad L; Cristol, Daniel A; Gerson, Alexander R

    2016-01-01

    The pollutant methylmercury accumulates within lean tissues of birds and other animals. Migrating birds catabolize substantial amounts of lean tissue during flight which may mobilize methylmercury and increase circulating levels of this neurotoxin. As a model for a migrating songbird, we fasted zebra finches (Taeniopygia guttata) that had been dosed with 0.0, 0.1, and 0.6 parts per million (ppm) dietary methylmercury and measured changes in blood total mercury concentrations (THg) in relation to reductions in lean mass. Birds lost 6-16% of their lean mass during the fast, and THg increased an average of 12% and 11% in the 0.1 and 0.6 ppm treatments, respectively. Trace amounts of THg in the 0.0 ppm control group also increased as a result of fasting, but remained extremely low. THg increased 0.4 ppm for each gram of lean mass catabolized in the higher dose birds. Our findings indicate that methylmercury is mobilized from lean tissues during protein catabolism and results in acute increases in circulating concentrations. This is a previously undocumented potential threat to wild migratory birds, which may experience greater surges in circulating methylmercury than demonstrated here as a result of their greater reductions in lean mass. PMID:27173605

  19. Mobilization of mercury from lean tissues during simulated migratory fasting in a model songbird

    PubMed Central

    Seewagen, Chad L.; Cristol, Daniel A.; Gerson, Alexander R.

    2016-01-01

    The pollutant methylmercury accumulates within lean tissues of birds and other animals. Migrating birds catabolize substantial amounts of lean tissue during flight which may mobilize methylmercury and increase circulating levels of this neurotoxin. As a model for a migrating songbird, we fasted zebra finches (Taeniopygia guttata) that had been dosed with 0.0, 0.1, and 0.6 parts per million (ppm) dietary methylmercury and measured changes in blood total mercury concentrations (THg) in relation to reductions in lean mass. Birds lost 6–16% of their lean mass during the fast, and THg increased an average of 12% and 11% in the 0.1 and 0.6 ppm treatments, respectively. Trace amounts of THg in the 0.0 ppm control group also increased as a result of fasting, but remained extremely low. THg increased 0.4 ppm for each gram of lean mass catabolized in the higher dose birds. Our findings indicate that methylmercury is mobilized from lean tissues during protein catabolism and results in acute increases in circulating concentrations. This is a previously undocumented potential threat to wild migratory birds, which may experience greater surges in circulating methylmercury than demonstrated here as a result of their greater reductions in lean mass. PMID:27173605

  20. Models for IP/MPLS routing performance: convergence, fast reroute, and QoS impact

    NASA Astrophysics Data System (ADS)

    Choudhury, Gagan L.

    2004-09-01

    We show how to model the black-holing and looping of traffic during an Interior Gateway Protocol (IGP) convergence event at an IP network and how to significantly improve both the convergence time and packet loss duration through IGP parameter tuning and algorithmic improvement. We also explore some congestion avoidance and congestion control algorithms that can significantly improve stability of networks in the face of occasional massive control message storms. Specifically we show the positive impacts of prioritizing Hello and Acknowledgement packets and slowing down LSA generation and retransmission generation on detecting congestion in the network. For some types of video, voice signaling and circuit emulation applications it is necessary to reduce traffic loss durations following a convergence event to below 100 ms and we explore that using Fast Reroute algorithms based on Multiprotocol Label Switching Traffic Engineering (MPLS-TE) that effectively bypasses IGP convergence. We explore the scalability of primary and backup MPLS-TE tunnels where MPLS-TE domain is in the backbone-only or edge-to-edge. We also show how much extra backbone resource is needed to support Fast Reroute and how can that be reduced by taking advantage of Constrained Shortest Path (CSPF) routing of MPLS-TE and by reserving less than 100% of primary tunnel bandwidth during Fast Reroute.

  1. Fast and accurate analytical model to solve inverse problem in SHM using Lamb wave propagation

    NASA Astrophysics Data System (ADS)

    Poddar, Banibrata; Giurgiutiu, Victor

    2016-04-01

    Lamb wave propagation is at the center of attention of researchers for structural health monitoring of thin walled structures. This is due to the fact that Lamb wave modes are natural modes of wave propagation in these structures with long travel distances and without much attenuation. This brings the prospect of monitoring large structure with few sensors/actuators. However the problem of damage detection and identification is an "inverse problem" where we do not have the luxury to know the exact mathematical model of the system. On top of that the problem is more challenging due to the confounding factors of statistical variation of the material and geometric properties. Typically this problem may also be ill posed. Due to all these complexities the direct solution of the problem of damage detection and identification in SHM is impossible. Therefore an indirect method using the solution of the "forward problem" is popular for solving the "inverse problem". This requires a fast forward problem solver. Due to the complexities involved with the forward problem of scattering of Lamb waves from damages researchers rely primarily on numerical techniques such as FEM, BEM, etc. But these methods are slow and practically impossible to be used in structural health monitoring. We have developed a fast and accurate analytical forward problem solver for this purpose. This solver, CMEP (complex modes expansion and vector projection), can simulate scattering of Lamb waves from all types of damages in thin walled structures fast and accurately to assist the inverse problem solver.

  2. Mobilization of mercury from lean tissues during simulated migratory fasting in a model songbird.

    PubMed

    Seewagen, Chad L; Cristol, Daniel A; Gerson, Alexander R

    2016-05-12

    The pollutant methylmercury accumulates within lean tissues of birds and other animals. Migrating birds catabolize substantial amounts of lean tissue during flight which may mobilize methylmercury and increase circulating levels of this neurotoxin. As a model for a migrating songbird, we fasted zebra finches (Taeniopygia guttata) that had been dosed with 0.0, 0.1, and 0.6 parts per million (ppm) dietary methylmercury and measured changes in blood total mercury concentrations (THg) in relation to reductions in lean mass. Birds lost 6-16% of their lean mass during the fast, and THg increased an average of 12% and 11% in the 0.1 and 0.6 ppm treatments, respectively. Trace amounts of THg in the 0.0 ppm control group also increased as a result of fasting, but remained extremely low. THg increased 0.4 ppm for each gram of lean mass catabolized in the higher dose birds. Our findings indicate that methylmercury is mobilized from lean tissues during protein catabolism and results in acute increases in circulating concentrations. This is a previously undocumented potential threat to wild migratory birds, which may experience greater surges in circulating methylmercury than demonstrated here as a result of their greater reductions in lean mass.

  3. Seismic response interpretation for heterogeneous reservoir models

    SciTech Connect

    Fichtl, P.; Fournier, F.

    1995-08-01

    Seismic information is crucial to constrain the reservoir image between wells. However, in heterogeneous environments, it is often difficult to interpret the seismic response of the reservoir, especially with limited well control. Analyses of synthetic seismic responses of typical reservoir models are helpful for defining the geological information contained in the seismic data. We propose a geological interpretation of seismic responses of various models in the frame of fluvio-deltaic deposits. The first model is the intermediate unit of the Mesa Verde outcrop, whose seismic response was computed by elastic wave modelling, after assignment of elastic parameters constant by lithofacies. The other models correspond to stochastic lithofacies simulations with different geostatistical characteristics. Their seismic responses were computed with 1D modelling (convolution). The geological interpretation carried out on those synthetic seismic data is based on a calibration of the seismic parameters in terms of probabilities of encountering the different lithofacies. The technique we use is a non parametric discriminant analysis. The seismic parameters are the amplitudes for the convolution models or impedances and reflection coefficients for the first model for which a post-stack stratigraphic inversion was carried out. We compare the seismic derived lithofacies to the true ones to determine the potential of the seismic data for describing the reservoir heterogeneities. We use the different models to discuss: the impact of the spatial distribution of heterogeneities on the geological interpretation of the seismic data; the influence of the seismic lateral filtering on the interpretation the influence of the number of wells, used in the interpretation, on the final results.

  4. Fast azimuthally dependent model of the reflection of solar radiation by plane-parallel clouds.

    PubMed

    Davies, R

    1980-01-15

    A fast analytical model of the transfer of solar radiation in plane-parallel clouds is developed by extending the Eddington approximation to handle an azimuthally dependent radiance field. When compared with the more precise doubling method, the results from this approximate model show a typical accuracy of better than 3% for fluxes and 10% for intensities over a wide range of input parameters. This accuracy may deteriorate somewhat for small cloud thicknesses, large solar zenith angles, viewing angles close to the horizon, or viewing angles close to the solar azimuthal direction. The computational speed of the analytical model is, however, a few hundred times faster than that of the more precise models, which makes it well suited for applications involving iteration over spectral intervals, time intervals, or cloud populations.

  5. Three-dimensional Fast Flux Test Facility plenum model turbulent flow prediction and data comparison

    SciTech Connect

    Eyler, L.L.; Sawdye, R.W.

    1981-01-01

    Two- and three-dimensional numerical simulations of turbulent flow in a scaled Fast Flux Test Facility (FFTF) upper plenum model were performed using the TEMPEST hydrothermal code. A standard k-element of model was used to describe turbulence through an effective viscosity. Comparisons with previously reported mean velocity and turbulence field data measured in the plenum model and two-dimensional numerical simulations using the TEACH code were made. Predicted horizontal and vertical mean velocities and turbulent kinetic energy are shown to be in good agreement with available experimental data when inlet conditions of the dissipation of turbulent kinetic energy are appropriately prescribed. The three-dimensional quarter-symmetry simulation predicts the turbulent kinetic energy field significantly better than the two-dimensional centerplane simulations. These results lead to conclusions concerning deficiencies in the experimental data and the turbulence model.

  6. SCOUT: a fast Monte-Carlo modeling tool of scintillation camera output†

    PubMed Central

    Hunter, William C J; Barrett, Harrison H.; Muzi, John P.; McDougald, Wendy; MacDonald, Lawrence R.; Miyaoka, Robert S.; Lewellen, Thomas K.

    2013-01-01

    We have developed a Monte-Carlo photon-tracking and readout simulator called SCOUT to study the stochastic behavior of signals output from a simplified rectangular scintillation-camera design. SCOUT models the salient processes affecting signal generation, transport, and readout of a scintillation camera. Presently, we compare output signal statistics from SCOUT to experimental results for both a discrete and a monolithic camera. We also benchmark the speed of this simulation tool and compare it to existing simulation tools. We find this modeling tool to be relatively fast and predictive of experimental results. Depending on the modeled camera geometry, we found SCOUT to be 4 to 140 times faster than other modeling tools. PMID:23640136

  7. ellc: A fast, flexible light curve model for detached eclipsing binary stars and transiting exoplanets

    NASA Astrophysics Data System (ADS)

    Maxted, P. F. L.

    2016-06-01

    Context. Very high quality light curves are now available for thousands of detached eclipsing binary stars and transiting exoplanet systems as a result of surveys for transiting exoplanets and other large-scale photometric surveys. Aims: I have developed a binary star model (ellc) that can be used to analyse the light curves of detached eclipsing binary stars and transiting exoplanet systems that is fast and accurate, and that can include the effects of star spots, Doppler boosting and light-travel time within binaries with eccentric orbits. Methods: The model represents the stars as triaxial ellipsoids. The apparent flux from the binary is calculated using Gauss-Legendre integration over the ellipses that are the projection of these ellipsoids on the sky. The model can also be used to calculate the flux-weighted radial velocity of the stars during an eclipse (Rossiter-McLaghlin effect). The main features of the model have been tested by comparison to observed data and other light curve models. Results: The model is found to be accurate enough to analyse the very high quality photometry that is now available from space-spaced instruments, flexible enough to model a wide range of eclipsing binary stars and extrasolar planetary systems, and fast enough to enable the use of modern Monte Carlo methods for data analysis and model testing. The software package is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/591/A111

  8. Fast three-material modeling with triple arch projection for electronic cleansing in CTC.

    PubMed

    Lee, Hyunna; Lee, Jeongjin; Kim, Bohyoung; Kim, Se Hyung; Shin, Yeong-Gil

    2014-07-01

    In this paper, we propose a fast three-material modeling for electronic cleansing (EC) in computed tomographic colonography. Using a triple arch projection, our three-material modeling provides a very quick estimate of the three-material fractions to remove ridge-shaped artifacts at the T-junctions where air, soft-tissue (ST), and tagged residues (TRs) meet simultaneously. In our approach, colonic components including air, TR, the layer between air and TR, the layer between ST and TR (L(ST/TR)), and the T-junction are first segmented. Subsequently, the material fraction of ST for each voxel in L(ST/TR) and the T-junction is determined. Two-material fractions of the voxels in L(ST/TR) are derived based on a two-material transition model. On the other hand, three-material fractions of the voxels in the T-junction are estimated based on our fast three-material modeling with triple arch projection. Finally, the CT density value of each voxel is updated based on our fold-preserving reconstruction model. Experimental results using ten clinical datasets demonstrate that the proposed three-material modeling successfully removed the T-junction artifacts and clearly reconstructed the whole colon surface while preserving the submerged folds well. Furthermore, compared with the previous three-material transition model, the proposed three-material modeling resulted in about a five-fold increase in speed with the better preservation of submerged folds and the similar level of cleansing quality in T-junction regions.

  9. Multiscale modeling of mucosal immune responses

    PubMed Central

    2015-01-01

    Computational modeling techniques are playing increasingly important roles in advancing a systems-level mechanistic understanding of biological processes. Computer simulations guide and underpin experimental and clinical efforts. This study presents ENteric Immune Simulator (ENISI), a multiscale modeling tool for modeling the mucosal immune responses. ENISI's modeling environment can simulate in silico experiments from molecular signaling pathways to tissue level events such as tissue lesion formation. ENISI's architecture integrates multiple modeling technologies including ABM (agent-based modeling), ODE (ordinary differential equations), SDE (stochastic modeling equations), and PDE (partial differential equations). This paper focuses on the implementation and developmental challenges of ENISI. A multiscale model of mucosal immune responses during colonic inflammation, including CD4+ T cell differentiation and tissue level cell-cell interactions was developed to illustrate the capabilities, power and scope of ENISI MSM. Background Computational techniques are becoming increasingly powerful and modeling tools for biological systems are of greater needs. Biological systems are inherently multiscale, from molecules to tissues and from nano-seconds to a lifespan of several years or decades. ENISI MSM integrates multiple modeling technologies to understand immunological processes from signaling pathways within cells to lesion formation at the tissue level. This paper examines and summarizes the technical details of ENISI, from its initial version to its latest cutting-edge implementation. Implementation Object-oriented programming approach is adopted to develop a suite of tools based on ENISI. Multiple modeling technologies are integrated to visualize tissues, cells as well as proteins; furthermore, performance matching between the scales is addressed. Conclusion We used ENISI MSM for developing predictive multiscale models of the mucosal immune system during gut

  10. Combustion response modeling for composite solid propellants

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A computerized mathematical model of the combustion response function of composite solid propellants was developed with particular attention to the contributions of the solid phase heterogeneity. The one-dimensional model treats the solid phase as alternating layers of ammonium perchlorate and binder, with an exothermic melt layer at the surface. Solution of the Fourier heat equation in the solid provides temperature and heat flux distributions with space and time. The problem is solved by conserving the heat flux at the surface from that produced by a suitable model of the gas phase. An approximation of the BDP flame model is utilized to represent the gas phase. By the use of several reasonable assumptions, it is found that a significant portion of the problem can be solved in closed form. A method is presented by which the model can be applied to tetramodal particle size distributions. A computerized steady-state version of the model was completed, which served to validate the various approximations and lay a foundation for the combustion response modeling. The combustion response modeling was completed in a form which does not require an iterative solution, and some preliminary results were acquired.

  11. Comparison of models of fast saturable absorption in passively modelocked lasers.

    PubMed

    Wang, Shaokang; Marks, Brian S; Menyuk, Curtis R

    2016-09-01

    Fast saturable absorbers (FSAs) play a critical role in stabilizing many passively modelocked lasers. The most commonly used averaged model to study these lasers is the Haus modelocking equation (HME) that includes a third-order nonlinear FSA. However, it predicts a narrow region of stability that is inconsistent with experiments. To better replicate the laser physics, averaged laser models that include FSAs with higher-than-third-order nonlinearities have been introduced. Here, we compare three common FSA models to each other and to the HME using the recently-developed boundary tracking algorithms. The three FSA models are the cubic-quintic model, the sinusoidal model, and the algebraic model. We find that all three models predict the existence of a stable high-energy solution that is not present in the HME and have a much larger stable operating region. We also find that all three models predict qualitatively similar stability diagrams. We conclude that averaged laser models that include FSAs with higher-than-third-order nonlinearity should be used when studying the stability of passively modelocked lasers.

  12. Comparison of models of fast saturable absorption in passively modelocked lasers

    NASA Astrophysics Data System (ADS)

    Wang, Shaokang; Marks, Brian S.; Menyuk, Curtis R.

    2016-09-01

    Fast saturable absorbers (FSAs) play a critical role in stabilizing many passively modelocked lasers. The most commonly used averaged model to study these lasers is the Haus modelocking equation (HME) that includes a third-order nonlinear FSA. However, it predicts a narrow region of stability that is inconsistent with experiments. To better replicate the laser physics, averaged laser models that include FSAs with higher-than-third-order nonlinearities have been introduced. Here, we compare three common FSA models to each other and to the HME using the recently-developed boundary tracking algorithms. The three FSA models are the cubic-quintic model, the sinusoidal model, and the algebraic model. We find that all three models predict the existence of a stable high-energy solution that is not present in the HME and have a much larger stable operating region. We also find that all three models predict qualitatively similar stability diagrams. We conclude that averaged laser models that include FSAs with higher-than-third-order nonlinearity should be used when studying the stability of passively modelocked lasers.

  13. Comparison of models of fast saturable absorption in passively modelocked lasers.

    PubMed

    Wang, Shaokang; Marks, Brian S; Menyuk, Curtis R

    2016-09-01

    Fast saturable absorbers (FSAs) play a critical role in stabilizing many passively modelocked lasers. The most commonly used averaged model to study these lasers is the Haus modelocking equation (HME) that includes a third-order nonlinear FSA. However, it predicts a narrow region of stability that is inconsistent with experiments. To better replicate the laser physics, averaged laser models that include FSAs with higher-than-third-order nonlinearities have been introduced. Here, we compare three common FSA models to each other and to the HME using the recently-developed boundary tracking algorithms. The three FSA models are the cubic-quintic model, the sinusoidal model, and the algebraic model. We find that all three models predict the existence of a stable high-energy solution that is not present in the HME and have a much larger stable operating region. We also find that all three models predict qualitatively similar stability diagrams. We conclude that averaged laser models that include FSAs with higher-than-third-order nonlinearity should be used when studying the stability of passively modelocked lasers. PMID:27607630

  14. Intercomparison of six fast-response sensors for the eddy-covariance flux measurement of nitrous oxide over agricultural grassland

    NASA Astrophysics Data System (ADS)

    Nemitz, Eiko; Famulari, Daniela; Ibrom, Andreas; Vermeulen, Alex; Hensen, Arjan; van den Bulk, Pim; Loubet, Benjamin; Laville, Patricia; Mammarella, Ivan; Haapanala, Sami; Lohila, Annalea; Laurila, Tuomas; Eva, Rabot; Laborde, Marie; Cowan, Nicholas; Anderson, Margaret; Helfter, Carole

    2015-04-01

    Nitrous oxide (N2O) is the third most important greenhouse gas and its terrestrial budget remains poorly constraint, with bottom up and top down estimates of country emissions often disagreeing by more than a factor of two. Whilst the measurements of the biosphere / atmosphere exchange of CO2 with micrometeorological methods is commonplace, emissions of CH4 and N2O are more commonly measured with enclosure techniques due to limitations in fast-response sensors with good signal-to-noise characteristics. Recent years have seen the development of a range of instruments based on optical spectroscopy. This started in the early 1990s with instruments based on lead salt lasers, which had temperamental long-term characteristics. More recent developments in quantum cascade lasers has lead to increasingly stable instruments, initially based on pulsed, later on continuous wave lasers. Within the context of the European FP7 Infrastructure Project InGOS ('Integrated non-CO2 Greenhouse gas Observing System'), we conducted an intercomparison of six fast response sensors for N2O: three more or less identical instruments based on off-axis Integrated Cavity Optical Spectrocopy (ICOS) (Los Gatos Research Inc.) and three instruments based on quantum cascade laser absorption spectrometry (Aerodyne Research Inc.): one older generation pulsed instrument (p-QCL) and two of the latest generation of compact continuous wave instruments (cw-QCL), operating at two different wavelengths. One of the ICOS instruments was operated with an inlet drier. In addition, the campaign was joined by a relaxed eddy-accumulation system linked to a FTIR spectrometer (Ecotech), a gradient system based on a home-built slower QCL (INRA Orleans) and a fast chamber system. Here we present the results of the study and a detailed examination of the various corrections and errors of the different instruments. Overall, with the exception of the older generation QCL, the average fluxes based on the different fast-response

  15. The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Metabolic response to the triglyceride (TG)-lowering drug, fenofibrate, is shaped by interactions between genetic and environmental factors, yet knowledge regarding the genetic determinants of this response is primarily limited to single gene effects. Since very low density lipoprotein (VLDL) is the...

  16. A geometric analysis of fast-slow models for stochastic gene expression.

    PubMed

    Popović, Nikola; Marr, Carsten; Swain, Peter S

    2016-01-01

    Stochastic models for gene expression frequently exhibit dynamics on several different scales. One potential time-scale separation is caused by significant differences in the lifetimes of mRNA and protein; the ratio of the two degradation rates gives a natural small parameter in the resulting chemical master equation, allowing for the application of perturbation techniques. Here, we develop a framework for the analysis of a family of 'fast-slow' models for gene expression that is based on geometric singular perturbation theory. We illustrate our approach by giving a complete characterisation of a standard two-stage model which assumes transcription, translation, and degradation to be first-order reactions. In particular, we present a systematic expansion procedure for the probability-generating function that can in principle be taken to any order in the perturbation parameter, allowing for an approximation of the corresponding propagator probabilities to that same order. For illustrative purposes, we perform this expansion explicitly to first order, both on the fast and the slow time-scales; then, we combine the resulting asymptotics into a composite fast-slow expansion that is uniformly valid in time. In the process, we extend, and prove rigorously, results previously obtained by Shahrezaei and Swain (Proc Natl Acad Sci USA 105(45):17256-17261, 2008) and Bokes et al. (J Math Biol 64(5):829-854, 2012; J Math Biol 65(3):493-520, 2012). We verify our asymptotics by numerical simulation, and we explore its practical applicability and the effects of a variation in the system parameters and the time-scale separation. Focussing on biologically relevant parameter regimes that induce translational bursting, as well as those in which mRNA is frequently transcribed, we find that the first-order correction can significantly improve the steady-state probability distribution. Similarly, in the time-dependent scenario, inclusion of the first-order fast asymptotics results in a

  17. Observations and modelling of fast ice growth in the Tiksi Bay, Laptev Sea

    NASA Astrophysics Data System (ADS)

    Bogorodsky, Petr; Makshtas, Aleksandr; Grubiy, Andrey; Kustov, Vasiliy

    2016-04-01

    Fast ice is one of the main features of sea ice cover in the Laptev Sea. The formation of this immobile ice which occupies up to 30% of the sea area and significantly affects the intensity of air-sea energy exchange in the coastal zones had been investigated during winter 2014-2015 in the Tiksi Bay (Buor-Khaya Gulf). The temperature measurements within sea ice thickness and under-ice sea layer using GeoPrecision thermistor string of 10 sensors together with measurements of snow and ice thicknesses were carried out at the distance of 0.5 km from the shore at the 3.5 m water depth. According to measurements temperature variations qualitatively repeat air temperature variations and, damping with depth, approach to sea water freezing temperature. Vertical temperature distributions allow to recognize snow, ice and water layers by profile inclination in each layer. The temperature profiles within growing ice were quasi-linear, indicating permanence of heat flux inside ice. The linearity of temperature profiles increased during ice growth. For calculations of fast ice evolution one-dimensional thermodynamic model was used. Besides the empirical formulae, based on frost degree-days, developed in 1930th for the Tiksi Bay was applied. Numerical experiments were carried out with constant values of thermal properties of all media and 10 ppt water salinity, as initial condition. The daily average data from Hydrometeorological Observatory Tiksi, located approximately 1 km from the site of ice observations, were used as atmospheric forcing. For the examined area evolutions of ice cover thickness estimated from direct measurements, the thermodynamic model and the empirical formulae were almost identical. The result indicates stability of hydrological and meteorological conditions, determining fast ice growth in the Tiksi Bay during last 75 years. Model simulations showed that in shallow waters the growth of ice thickness is stabilized due to increase of sub-ice water layer

  18. A geometric analysis of fast-slow models for stochastic gene expression.

    PubMed

    Popović, Nikola; Marr, Carsten; Swain, Peter S

    2016-01-01

    Stochastic models for gene expression frequently exhibit dynamics on several different scales. One potential time-scale separation is caused by significant differences in the lifetimes of mRNA and protein; the ratio of the two degradation rates gives a natural small parameter in the resulting chemical master equation, allowing for the application of perturbation techniques. Here, we develop a framework for the analysis of a family of 'fast-slow' models for gene expression that is based on geometric singular perturbation theory. We illustrate our approach by giving a complete characterisation of a standard two-stage model which assumes transcription, translation, and degradation to be first-order reactions. In particular, we present a systematic expansion procedure for the probability-generating function that can in principle be taken to any order in the perturbation parameter, allowing for an approximation of the corresponding propagator probabilities to that same order. For illustrative purposes, we perform this expansion explicitly to first order, both on the fast and the slow time-scales; then, we combine the resulting asymptotics into a composite fast-slow expansion that is uniformly valid in time. In the process, we extend, and prove rigorously, results previously obtained by Shahrezaei and Swain (Proc Natl Acad Sci USA 105(45):17256-17261, 2008) and Bokes et al. (J Math Biol 64(5):829-854, 2012; J Math Biol 65(3):493-520, 2012). We verify our asymptotics by numerical simulation, and we explore its practical applicability and the effects of a variation in the system parameters and the time-scale separation. Focussing on biologically relevant parameter regimes that induce translational bursting, as well as those in which mRNA is frequently transcribed, we find that the first-order correction can significantly improve the steady-state probability distribution. Similarly, in the time-dependent scenario, inclusion of the first-order fast asymptotics results in a

  19. Stiffening response of a cellular tensegrity model.

    PubMed

    Wendling, S; Oddou, C; Isabey, D

    1999-02-01

    Living cells exhibit, as most biological tissues, a stiffening (strain-hardening) response which reflects the nonlinearity of the stress-strain relationship. Tensegrity structures have been proposed as a comprehensive model of such a cell's mechanical response. Based on a theoretical model of a 30-element tensegrity structure, we propose a quantitative analysis of its nonlinear mechanical behavior under static conditions and large deformations. This study provides theoretical foundation to the passage from large-scale tensegrity models to microscale living cells, as well as the comparison between results obtained in biological specimens of different sizes. We found two non-dimensional parameters (L*-normalized element length and T*-normalized elastic tension) which govern the mechanical response of the structure for three types of loading tested (extension, compression and shear). The linear strain-hardening is uniquely observed for extension but differed for the two other types of loading tested. The stiffening response of the theoretical model was compared and discussed with the living cells stiffening response observed by different methods (shear flow experiments, micromanipulation and magnetocytometry). PMID:10049624

  20. SPH modeling of adhesion in fast dynamics: Application to the Cold Spray process

    NASA Astrophysics Data System (ADS)

    Profizi, Paul; Combescure, Alain; Ogawa, Kahuziro

    2016-04-01

    The objective of this paper is to show, in a specific case, the importance of modeling adhesive forces when simulating the bouncing of very small particles impacting a substrate at high speed. The implementation of this model into a fast-dynamics SPH code is described. Taking the example of an impacted elastic cylinder, we show that the adhesive forces, which are surface forces, play a significant role only if the particles are sufficiently small. The effect of the choice of the type of interaction law in the cohesive zone is studied and some conclusions on the relevance of the modeling of the adhesive forces for fast-dynamics impacts are drawn. Then, the adhesion model is used to simulate the Cold Spray process. An aluminum particle is projected against a substrate made of the same material at a velocity ranging from 200 to 1000 m ṡs-1. We study the effects of the various modeling assumptions on the final result: bouncing or sticking. Increasingly complex models are considered. At a 200 m ṡs-1 impact velocity, elastic behavior is assumed, the substrate being simply supported at its base and supplied with absorbing boundaries. The same absorbing boundaries are also used for all the other simulations. Then, plasticity is introduced and the impact velocity is increased up to 1000 m ṡs-1. At the highest velocities, the resulting strains are very significant. The calculations show that if the adhesion model is appropriately chosen, it is possible to reproduce the experimental observations: the particles stick to the substrate in a range of impact velocities surrounded by two velocity ranges in which the particles bounce.

  1. Proposed fast-response oxygen monitoring and control system for the Langley 8-foot high-temperature tunnel

    NASA Technical Reports Server (NTRS)

    Singh, J. J.; Davis, W. T.; Puster, R. L.

    1983-01-01

    A fast-response oxygen monitoring and control system, based on a Y2O3-stabilized ZrO2 sensor, was developed and tested in the laboratory. The system is capable of maintaining oxygen concentration in the CH4-O2-air combustion product gases at 20.9 + or - 1.0 percent. If the oxygen concentration in the exhaust stream differs from that in normal air by 25 percent or more, an alarm signal is provided for automatic tunnel shutdown. The overall prototype system response time was reduced from about 1 sec in the original configuration to about 0.2 sec. The basis of operation and the results of laboratory tests of the system are described.

  2. Continuously tunable and fast-response terahertz metamaterials using in-plane-switching dual-frequency liquid crystal cells.

    PubMed

    Chen, Chia-Chun; Chiang, Wei-Fan; Tsai, Min-Cheng; Jiang, Shun-An; Chang, Tsung-Hao; Wang, Song-Hang; Huang, Chia-Yi

    2015-05-01

    A metamaterial that is embedded in an in-plane-switching dual-frequency liquid crystal cell is used to develop an electrically controllable terahertz (THz) metamaterial. The resonance peak of the metamaterial can be redshifted and blueshifted as the frequency of an external voltage is switched, and the response times for the redshift and blueshift are 1.044 and 1.376 ms, respectively. A simulation confirms the spectral redshift and blueshift. The variation in peak frequency as a function of applied frequency at the external voltage is presented. Experimental results show that the resonance peak of the metamaterial can be continuously tuned within a frequency range of 15 GHz as the applied frequency is switched between 19 and 22 kHz. Therefore, this metamaterial is a continuously tunable and fast-response THz filter and could be used for THz imaging and THz telecommunications.

  3. The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons

    PubMed Central

    Denekamp, J.

    1974-01-01

    The response of an experimental sarcoma to single doses and two fractions of x-rays and fast neutrons has been investigated to test the hypothesis that slowly shrinking sarcomata will reoxygenate poorly and therefore will benefit more from fractionated neutron treatment than from fractionated x-ray treatment, in contrast with rapidly shrinking carcinomata. Neutrons were approximately three times more effective than x-rays, both for single doses and for two fractions given in 48 hours, when regrowth was used as a measure of response. This observation is closely similar to results previously obtained on a rat fibrosarcoma and contrasts with previous results from a mouse mammary carcinoma, and is in agreement with the hypothesis. PMID:4855057

  4. Continuously tunable and fast-response terahertz metamaterials using in-plane-switching dual-frequency liquid crystal cells.

    PubMed

    Chen, Chia-Chun; Chiang, Wei-Fan; Tsai, Min-Cheng; Jiang, Shun-An; Chang, Tsung-Hao; Wang, Song-Hang; Huang, Chia-Yi

    2015-05-01

    A metamaterial that is embedded in an in-plane-switching dual-frequency liquid crystal cell is used to develop an electrically controllable terahertz (THz) metamaterial. The resonance peak of the metamaterial can be redshifted and blueshifted as the frequency of an external voltage is switched, and the response times for the redshift and blueshift are 1.044 and 1.376 ms, respectively. A simulation confirms the spectral redshift and blueshift. The variation in peak frequency as a function of applied frequency at the external voltage is presented. Experimental results show that the resonance peak of the metamaterial can be continuously tuned within a frequency range of 15 GHz as the applied frequency is switched between 19 and 22 kHz. Therefore, this metamaterial is a continuously tunable and fast-response THz filter and could be used for THz imaging and THz telecommunications. PMID:25927774

  5. Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial

    PubMed Central

    Albert, Dustin; Belsky, Daniel W.; Crowley, D. Max; Latendresse, Shawn J.; Aliev, Fazil; Riley, Brien; Sun, Cuie; Dick, Danielle M.; Dodge, Kenneth R.

    2014-01-01

    Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track Randomized Control Trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era. PMID:26106668

  6. Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.

    PubMed

    Albert, Dustin; Belsky, Daniel W; Crowley, D Max; Latendresse, Shawn J; Aliev, Fazil; Riley, Brien; Sun, Cuie; Dick, Danielle M; Dodge, Kenneth A

    2015-01-01

    Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era.

  7. Fast response Fabry-Perot interferometer microfluidic refractive index fiber sensor based on concave-core photonic crystal fiber.

    PubMed

    Tian, Jiajun; Lu, Zejin; Quan, Mingran; Jiao, Yuzhu; Yao, Yong

    2016-09-01

    We report a fast response microfluidic Fabry-Perot (FP) interferometer refractive index (RI) fiber sensor based on a concave-core photonic crystal fiber (CPCF), which is formed by directly splicing a section CPCF with a section of single mode fiber. The CPCF is made by cleaving a section of multimode photonic crystal fiber with an axial tension. The shallow concave-core of CPCF naturally forms the FP cavity with a very short cavity length. The inherent large air holes in the cladding of CPCF are used as the open channels to let liquid sample come in and out of FP cavity. In order to shorten the liquid channel length and eliminate the harmful reflection from the outside end face of the CPCF, the CPCF is cleaved with a tilted tensile force. Due to the very small cavity capacity, the short length and the large sectional area of the microfluidic channels, the proposed sensor provides an easy-in and easy-out structure for liquids, leading to great decrement of the measuring time. The proposed sensor exhibits fast measuring speed, the measuring time is less than 359 and 23 ms for distilled water and pure ethanol, respectively. We also experimentally study and demonstrate the superior performances of the sensor in terms of high RI sensitivity, good linear response, low temperature cross-sensitivity and easy fabrication.

  8. Fast response Fabry-Perot interferometer microfluidic refractive index fiber sensor based on concave-core photonic crystal fiber.

    PubMed

    Tian, Jiajun; Lu, Zejin; Quan, Mingran; Jiao, Yuzhu; Yao, Yong

    2016-09-01

    We report a fast response microfluidic Fabry-Perot (FP) interferometer refractive index (RI) fiber sensor based on a concave-core photonic crystal fiber (CPCF), which is formed by directly splicing a section CPCF with a section of single mode fiber. The CPCF is made by cleaving a section of multimode photonic crystal fiber with an axial tension. The shallow concave-core of CPCF naturally forms the FP cavity with a very short cavity length. The inherent large air holes in the cladding of CPCF are used as the open channels to let liquid sample come in and out of FP cavity. In order to shorten the liquid channel length and eliminate the harmful reflection from the outside end face of the CPCF, the CPCF is cleaved with a tilted tensile force. Due to the very small cavity capacity, the short length and the large sectional area of the microfluidic channels, the proposed sensor provides an easy-in and easy-out structure for liquids, leading to great decrement of the measuring time. The proposed sensor exhibits fast measuring speed, the measuring time is less than 359 and 23 ms for distilled water and pure ethanol, respectively. We also experimentally study and demonstrate the superior performances of the sensor in terms of high RI sensitivity, good linear response, low temperature cross-sensitivity and easy fabrication. PMID:27607621

  9. FastGGM: An Efficient Algorithm for the Inference of Gaussian Graphical Model in Biological Networks.

    PubMed

    Wang, Ting; Ren, Zhao; Ding, Ying; Fang, Zhou; Sun, Zhe; MacDonald, Matthew L; Sweet, Robert A; Wang, Jieru; Chen, Wei

    2016-02-01

    Biological networks provide additional information for the analysis of human diseases, beyond the traditional analysis that focuses on single variables. Gaussian graphical model (GGM), a probability model that characterizes the conditional dependence structure of a set of random variables by a graph, has wide applications in the analysis of biological networks, such as inferring interaction or comparing differential networks. However, existing approaches are either not statistically rigorous or are inefficient for high-dimensional data that include tens of thousands of variables for making inference. In this study, we propose an efficient algorithm to implement the estimation of GGM and obtain p-value and confidence interval for each edge in the graph, based on a recent proposal by Ren et al., 2015. Through simulation studies, we demonstrate that the algorithm is faster by several orders of magnitude than the current implemented algorithm for Ren et al. without losing any accuracy. Then, we apply our algorithm to two real data sets: transcriptomic data from a study of childhood asthma and proteomic data from a study of Alzheimer's disease. We estimate the global gene or protein interaction networks for the disease and healthy samples. The resulting networks reveal interesting interactions and the differential networks between cases and controls show functional relevance to the diseases. In conclusion, we provide a computationally fast algorithm to implement a statistically sound procedure for constructing Gaussian graphical model and making inference with high-dimensional biological data. The algorithm has been implemented in an R package named "FastGGM".

  10. Fast and accurate computation of system matrix for area integral model-based algebraic reconstruction technique

    NASA Astrophysics Data System (ADS)

    Zhang, Shunli; Zhang, Dinghua; Gong, Hao; Ghasemalizadeh, Omid; Wang, Ge; Cao, Guohua

    2014-11-01

    Iterative algorithms, such as the algebraic reconstruction technique (ART), are popular for image reconstruction. For iterative reconstruction, the area integral model (AIM) is more accurate for better reconstruction quality than the line integral model (LIM). However, the computation of the system matrix for AIM is more complex and time-consuming than that for LIM. Here, we propose a fast and accurate method to compute the system matrix for AIM. First, we calculate the intersection of each boundary line of a narrow fan-beam with pixels in a recursive and efficient manner. Then, by grouping the beam-pixel intersection area into six types according to the slopes of the two boundary lines, we analytically compute the intersection area of the narrow fan-beam with the pixels in a simple algebraic fashion. Overall, experimental results show that our method is about three times faster than the Siddon algorithm and about two times faster than the distance-driven model (DDM) in computation of the system matrix. The reconstruction speed of our AIM-based ART is also faster than the LIM-based ART that uses the Siddon algorithm and DDM-based ART, for one iteration. The fast reconstruction speed of our method was accomplished without compromising the image quality.

  11. Modeling fast-ion transport during toroidal Alfven eigenmode avalanches in National Spherical Torus Experiment

    SciTech Connect

    Fredrickson, E. D.; Bell, R. E.; Darrow, D. S.; Gorelenkov, N. N.; Kramer, G. J.; Medley, S. S.; White, R. B.; Crocker, N. A.; Kubota, S.; Levinton, F. M.; Yuh, H.; Liu, D.; Podesta, M.; Tritz, K.

    2009-12-15

    Experiments on the National Spherical Torus Experiment [M. Ono et al., Nucl. Fusion 40, 557 (2000)] found strong bursts of toroidal Alfven eigenmode (TAE) activity correlated with abrupt drops in the neutron rate. A fairly complete data set offers the opportunity to benchmark the NOVA[C. Z. Cheng, Phys. Rep. 211, 1 (1992)] and ORBIT[R. B. White and M. S. Chance, Phys. Fluids 27, 2455 (1984)] codes in the low aspect ratio tokamak (ST) geometry. The internal structure of TAE was modeled with NOVA and good agreement is found with measurements made with an array of five fixed-frequency reflectometers. The fast-ion transport resulting from these bursts of multiple TAE was then modeled with the ORBIT code. The simulations are reasonably consistent with the observed drop in neutron rate, however, further refinements in both the simulation of the TAE structure and in the modeling of the fast-ion transport are needed. Benchmarking stability codes against present experiments is an important step in developing the predictive capability needed to plan future experiments.

  12. FastGGM: An Efficient Algorithm for the Inference of Gaussian Graphical Model in Biological Networks.

    PubMed

    Wang, Ting; Ren, Zhao; Ding, Ying; Fang, Zhou; Sun, Zhe; MacDonald, Matthew L; Sweet, Robert A; Wang, Jieru; Chen, Wei

    2016-02-01

    Biological networks provide additional information for the analysis of human diseases, beyond the traditional analysis that focuses on single variables. Gaussian graphical model (GGM), a probability model that characterizes the conditional dependence structure of a set of random variables by a graph, has wide applications in the analysis of biological networks, such as inferring interaction or comparing differential networks. However, existing approaches are either not statistically rigorous or are inefficient for high-dimensional data that include tens of thousands of variables for making inference. In this study, we propose an efficient algorithm to implement the estimation of GGM and obtain p-value and confidence interval for each edge in the graph, based on a recent proposal by Ren et al., 2015. Through simulation studies, we demonstrate that the algorithm is faster by several orders of magnitude than the current implemented algorithm for Ren et al. without losing any accuracy. Then, we apply our algorithm to two real data sets: transcriptomic data from a study of childhood asthma and proteomic data from a study of Alzheimer's disease. We estimate the global gene or protein interaction networks for the disease and healthy samples. The resulting networks reveal interesting interactions and the differential networks between cases and controls show functional relevance to the diseases. In conclusion, we provide a computationally fast algorithm to implement a statistically sound procedure for constructing Gaussian graphical model and making inference with high-dimensional biological data. The algorithm has been implemented in an R package named "FastGGM". PMID:26872036

  13. Fokker-Planck/Ray Tracing for Electron Bernstein and Fast Wave Modeling in Support of NSTX

    SciTech Connect

    Harvey, R. W.

    2009-11-12

    This DOE grant supported fusion energy research, a potential long-term solution to the world's energy needs. Magnetic fusion, exemplified by confinement of very hot ionized gases, i.e., plasmas, in donut-shaped tokamak vessels is a leading approach for this energy source. Thus far, a mixture of hydrogen isotopes has produced 10's of megawatts of fusion power for seconds in a tokamak reactor at Princeton Plasma Physics Laboratory in New Jersey. The research grant under consideration, ER54684, uses computer models to aid in understanding and projecting efficacy of heating and current drive sources in the National Spherical Torus Experiment, a tokamak variant, at PPPL. The NSTX experiment explores the physics of very tight aspect ratio, almost spherical tokamaks, aiming at producing steady-state fusion plasmas. The current drive is an integral part of the steady-state concept, maintaining the magnetic geometry in the steady-state tokamak. CompX further developed and applied models for radiofrequency (rf) heating and current drive for applications to NSTX. These models build on a 30 year development of rf ray tracing (the all-frequencies GENRAY code) and higher dimensional Fokker-Planck rf-collisional modeling (the 3D collisional-quasilinear CQL3D code) at CompX. Two mainline current-drive rf modes are proposed for injection into NSTX: (1) electron Bernstein wave (EBW), and (2) high harmonic fast wave (HHFW) modes. Both these current drive systems provide a means for the rf to access the especially high density plasma--termed high beta plasma--compared to the strength of the required magnetic fields. The CompX studies entailed detailed modeling of the EBW to calculate the efficiency of the current drive system, and to determine its range of flexibility for driving current at spatial locations in the plasma cross-section. The ray tracing showed penetration into NSTX bulk plasma, relatively efficient current drive, but a limited ability to produce current over the whole

  14. Life history theory and breast cancer risk: methodological and theoretical challenges: Response to "Is estrogen receptor negative breast cancer risk associated with a fast life history strategy?".

    PubMed

    Aktipis, Athena

    2016-01-01

    In a meta-analysis published by myself and co-authors, we report differences in the life history risk factors for estrogen receptor negative (ER-) and estrogen receptor positive (ER+) breast cancers. Our meta-analysis did not find the association of ER- breast cancer risk with fast life history characteristics that Hidaka and Boddy suggest in their response to our article. There are a number of possible explanations for the differences between their conclusions and the conclusions we drew from our meta-analysis, including limitations of our meta-analysis and methodological challenges in measuring and categorizing estrogen receptor status. These challenges, along with the association of ER+ breast cancer with slow life history characteristics, may make it challenging to find a clear signal of ER- breast cancer with fast life history characteristics, even if that relationship does exist. The contradictory results regarding breast cancer risk and life history characteristics illustrate a more general challenge in evolutionary medicine: often different sub-theories in evolutionary biology make contradictory predictions about disease risk. In this case, life history models predict that breast cancer risk should increase with faster life history characteristics, while the evolutionary mismatch hypothesis predicts that breast cancer risk should increase with delayed reproduction. Whether life history tradeoffs contribute to ER- breast cancer is still an open question, but current models and several lines of evidence suggest that it is a possibility. PMID:26874356

  15. Fast response electromagnetic follow-ups from low latency GW triggers

    NASA Astrophysics Data System (ADS)

    Howell, E. J.; Chu, Q.; Rowlinson, A.; Gao, H.; Zhang, B.; Tingay, S. J.; Boër, M.; Wen, L.

    2016-05-01

    We investigate joint low-latency gravitational wave (GW) detection and prompt electromagnetic (EM) follow-up observations of coalescing binary neutron stars (BNSs). Assuming that BNS mergers are associated with short duration gamma ray bursts (SGRBs), we evaluate if rapid EM follow-ups can capture the prompt emission, early engine activity or reveal any potential by-products such as magnetars or fast radio bursts. To examine the expected performance of extreme low-latency search pipelines, we simulate a population of coalescing BNSs and use these to estimate the detectability and localisation efficiency at different times before merger. Using observational SGRB flux data corrected to the range of the advanced GW interferometric detectors, we determine what EM observations could be achieved from low-frequency radio up to high energy γ-ray. We show that while challenging, breakthrough multi-messenger science is possible through low latency pipelines.

  16. C-peptide-like material in rat brain: response to fasting and glucose ingestion.

    PubMed

    Jezová, D; Vigas, M; Sadlon, J

    1985-12-01

    Because of controversial data on the presence of insulin in the central nervous system, the presence of C-peptide immunoreactivity was followed in acid/ethanol extracts of the rat brain. C-peptide-like material was detected in whole brain extracts as well as in several brain fragments. Immunoreactive C-peptide concentrations were significantly higher in hypothalamus and olfactory bulb as compared to those in other brain regions sampled. Fasting for 72 h resulted in a decrease and oral glucose administration (0.75-1.5 g given in form of 25% water solution 30 min before sacrifice) was followed by an increase of C-peptide-like immunoreactivity in both plasma and hypothalamus. PMID:3878779

  17. Studies on the response of 3He and 4He proportional counters to monoenergetic fast neutrons

    NASA Astrophysics Data System (ADS)

    Manolopoulou, M.; Fragopoulou, M.; Stoulos, S.; Koukorava, C.; Spyrou, A.; Perdikakis, G.; Hashemi-Nezhad, S. R.; Zamani, M.

    2006-06-01

    Two helium filled proportional counters ( 3He and 4He) were studied to establish the optimum operating conditions when these counters are used for fast neutron measurements, as well as to examine the linearity of the pulse height with neutron energy. The detectors were irradiated with mono-energetic neutrons in the energy range of 230 keV-22 MeV, produced via 7Li(n,p) 7Be, 2H(d,n) 3He and 3H(d,n) 4He reactions in a Tandem Van de Graff accelerator. The gamma ray contribution to the obtained pulse height distribution and the resolution of the counters as a function of shaping time constant and applied high voltage were studied.

  18. Development and application of modeling tools for sodium fast reactor inspection

    SciTech Connect

    Le Bourdais, Florian; Marchand, Benoît; Baronian, Vahan

    2014-02-18

    To support the development of in-service inspection methods for the Advanced Sodium Test Reactor for Industrial Demonstration (ASTRID) project led by the French Atomic Energy Commission (CEA), several tools that allow situations specific to Sodium cooled Fast Reactors (SFR) to be modeled have been implemented in the CIVA software and exploited. This paper details specific applications and results obtained. For instance, a new specular reflection model allows the calculation of complex echoes from scattering structures inside the reactor vessel. EMAT transducer simulation models have been implemented to develop new transducers for sodium visualization and imaging. Guided wave analysis tools have been developed to permit defect detection in the vessel shell. Application examples and comparisons with experimental data are presented.

  19. Benchmark specifications and data requirements for initial modeling of the China experimental fast reactor.

    SciTech Connect

    Fanning, T. H.; Nuclear Engineering Division

    2010-06-04

    A specification is proposed for an initial transient benchmark analysis of the China Experimental Fast Reactor design based on the analysis capabilities of the SAS4A/SASSYS-1 code. For the initial benchmark, a single-channel protected transient overpower accident is defined. Reactivity feedback coefficients will not be required and simplified material properties are recommended. This report also describes the data required for developing the modeling input. This data includes assembly geometry, reactor power distributions, kinetics and decay heat data, and material properties. Comparisons of benchmark results will take place at a future SAS4A/SASSYS-1 training meeting planned to occur at Argonne National Laboratory. Future benchmark specifications will be planned to expand upon this initial model to include more complex reactivity feedback models, material properties, additional assembly geometry, and primary and intermediate coolant systems.

  20. Fast, Accurate RF Propagation Modeling and Simulation Tool for Highly Cluttered Environments

    SciTech Connect

    Kuruganti, Phani Teja

    2007-01-01

    As network centric warfare and distributed operations paradigms unfold, there is a need for robust, fast wireless network deployment tools. These tools must take into consideration the terrain of the operating theater, and facilitate specific modeling of end to end network performance based on accurate RF propagation predictions. It is well known that empirical models can not provide accurate, site specific predictions of radio channel behavior. In this paper an event-driven wave propagation simulation is proposed as a computationally efficient technique for predicting critical propagation characteristics of RF signals in cluttered environments. Convincing validation and simulator performance studies confirm the suitability of this method for indoor and urban area RF channel modeling. By integrating our RF propagation prediction tool, RCSIM, with popular packetlevel network simulators, we are able to construct an end to end network analysis tool for wireless networks operated in built-up urban areas.

  1. Development and application of modeling tools for sodium fast reactor inspection

    NASA Astrophysics Data System (ADS)

    Le Bourdais, Florian; Marchand, Benoît; Baronian, Vahan

    2014-02-01

    To support the development of in-service inspection methods for the Advanced Sodium Test Reactor for Industrial Demonstration (ASTRID) project led by the French Atomic Energy Commission (CEA), several tools that allow situations specific to Sodium cooled Fast Reactors (SFR) to be modeled have been implemented in the CIVA software and exploited. This paper details specific applications and results obtained. For instance, a new specular reflection model allows the calculation of complex echoes from scattering structures inside the reactor vessel. EMAT transducer simulation models have been implemented to develop new transducers for sodium visualization and imaging. Guided wave analysis tools have been developed to permit defect detection in the vessel shell. Application examples and comparisons with experimental data are presented.

  2. Fasting modifies Aroclor 1254 impact on plasma cortisol, glucose and lactate responses to a handling disturbance in Arctic charr

    USGS Publications Warehouse

    Jorgensen, E.H.; Vijayan, M.M.; Aluru, N.; Maule, A.G.

    2002-01-01

    Integrated effects of polychlorinated biphenyl (PCB) and nutritional status on responses to handling disturbance were investigated in the Arctic charr (Salvelinus alpinus). The fish were orally contaminated with Aroclor 1254 and held either with or without food for 5 months before they were subjected to a 10-min handling disturbance. Food-deprived fish were given 0, 1, 10 or 100 mg PCB kg-1 and the fed fish 0 or 100 mg PCB kg-1. Plasma cortisol, glucose and lactate levels were measured at 0 (pre-handling), 1, 3, 6 and 23 h after the handling disturbance. Food-deprived control fish had elevated plasma cortisol levels compared with fed fish before handling. These basal cortisol levels were suppressed by PCB in food-deprived fish, and elevated by PCB in fed fish. The immediate cortisol and glucose responses to handling disturbance were suppressed by PCB in a dose-dependent way in food-deprived fish. Although these responses were also lowered by PCB in the fed fish, the effect was much less pronounced than in food-deprived fish. There were only minor effects on plasma lactate responses. Our findings suggest that the stress responses of the Arctic charr are compromised by PCB and that the long-term fasting, typical of high-latitude fish, makes these species particularly sensitive to organochlorines such as PCB. ?? 2002 Elsevier Science Inc. All rights reserved.

  3. Creating a Team Archive During Fast-Paced Anomaly Response Activities in Space Missions

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Hicks, LaDessa; Overland, David; Thronesbery, Carroll; Christofferesen, Klaus; Chow, Renee

    2002-01-01

    This paper describes a Web-based system to support the temporary Anomaly Response Team formed from distributed subteams in Space Shuttle and International Space Station missions. The system was designed for easy and flexible creation of small collections of files and links associated with work on a particular anomaly. The system supports privacy and levels of formality for the subteams. First we describe the supported groups and an anomaly response scenario. Then we describe the support system prototype, the Anomaly Response Tracking and Integration System (ARTIS). Finally, we describe our evaluation approach and the results of the evaluation.

  4. Advanced Atmospheric Modeling for Emergency Response.

    NASA Astrophysics Data System (ADS)

    Fast, Jerome D.; O'Steen, B. Lance; Addis, Robert P.

    1995-03-01

    Atmospheric transport and diffusion models are an important part of emergency response systems for industrial facilities that have the potential to release significant quantities of toxic or radioactive material into the atmosphere. An advanced atmospheric transport and diffusion modeling system for emergency response and environmental applications, based upon a three-dimensional mesoscale model, has been developed for the U.S. Department of Energy's Savannah River Site so that complex, time-dependent flow fields not explicitly measured can be routinely simulated. To overcome some of the current computational demands of mesoscale models, two operational procedures for the advanced atmospheric transport and diffusion modeling system are described including 1) a semiprognostic calculation to produce high-resolution wind fields for local pollutant transport in the vicinity of the Savannah River Site and 2) a fully prognostic calculation to produce a regional wind field encompassing the southeastern United States for larger-scale pollutant problems. Local and regional observations and large-scale model output are used by the mesoscale model for the initial conditions, lateral boundary conditions, and four-dimensional data assimilation procedure. This paper describes the current status of the modeling system and presents two case studies demonstrating the capabilities of both modes of operation. While the results from the case studies shown in this paper are preliminary and certainly not definitive, they do suggest that the mesoscale model has the potential for improving the prognostic capabilities of atmospheric modeling for emergency response at the Savannah River Site. Long-term model evaluation will be required to determine under what conditions significant forecast errors exist.

  5. Fast model-based X-ray CT reconstruction using spatially nonhomogeneous ICD optimization.

    PubMed

    Yu, Zhou; Thibault, Jean-Baptiste; Bouman, Charles A; Sauer, Ken D; Hsieh, Jiang

    2011-01-01

    Recent applications of model-based iterative reconstruction (MBIR) algorithms to multislice helical CT reconstructions have shown that MBIR can greatly improve image quality by increasing resolution as well as reducing noise and some artifacts. However, high computational cost and long reconstruction times remain as a barrier to the use of MBIR in practical applications. Among the various iterative methods that have been studied for MBIR, iterative coordinate descent (ICD) has been found to have relatively low overall computational requirements due to its fast convergence. This paper presents a fast model-based iterative reconstruction algorithm using spatially nonhomogeneous ICD (NH-ICD) optimization. The NH-ICD algorithm speeds up convergence by focusing computation where it is most needed. The NH-ICD algorithm has a mechanism that adaptively selects voxels for update. First, a voxel selection criterion VSC determines the voxels in greatest need of update. Then a voxel selection algorithm VSA selects the order of successive voxel updates based upon the need for repeated updates of some locations, while retaining characteristics for global convergence. In order to speed up each voxel update, we also propose a fast 1-D optimization algorithm that uses a quadratic substitute function to upper bound the local 1-D objective function, so that a closed form solution can be obtained rather than using a computationally expensive line search algorithm. We examine the performance of the proposed algorithm using several clinical data sets of various anatomy. The experimental results show that the proposed method accelerates the reconstructions by roughly a factor of three on average for typical 3-D multislice geometries.

  6. Towards a fast and efficient approach for modelling the patient-specific ventricular haemodynamics.

    PubMed

    de Vecchi, A; Gomez, A; Pushparajah, K; Schaeffter, T; Nordsletten, D A; Simpson, J M; Penney, G P; Smith, N P

    2014-09-01

    Computer modelling of the heart has emerged over the past decade as a powerful technique to explore the cardiovascular pathophysiology and inform clinical diagnosis. The current state-of-the-art in biophysical modelling requires a wealth of, potentially invasive, clinical data for the parametrisation and validation of the models, a process that is still too long and complex to be compatible with the clinical decision-making time. Therefore, there remains a need for models that can be quickly customised to reconstruct physical processes difficult to measure directly in patients. In this paper, we propose a less resource-intensive approach to modelling, whereby computational fluid-dynamics (CFD) models are constrained exclusively by boundary motion derived from imaging data through a validated wall tracking algorithm. These models are generated and parametrised based solely on ultrasound data, whose acquisition is fast, inexpensive and routine in all patients. To maximise the time and computational efficiency, a semi-automated pipeline is embedded in an image processing workflow to personalise the models. Applying this approach to two patient cases, we demonstrate this tool can be directly used in the clinic to interpret and complement the available clinical data by providing a quantitative indication of clinical markers that cannot be easily derived from imaging, such as pressure gradients and the flow energy.

  7. Fast parallel algorithm for three-dimensional distance-driven model in iterative computed tomography reconstruction

    NASA Astrophysics Data System (ADS)

    Chen, Jian-Lin; Li, Lei; Wang, Lin-Yuan; Cai, Ai-Long; Xi, Xiao-Qi; Zhang, Han-Ming; Li, Jian-Xin; Yan, Bin

    2015-02-01

    The projection matrix model is used to describe the physical relationship between reconstructed object and projection. Such a model has a strong influence on projection and backprojection, two vital operations in iterative computed tomographic reconstruction. The distance-driven model (DDM) is a state-of-the-art technology that simulates forward and back projections. This model has a low computational complexity and a relatively high spatial resolution; however, it includes only a few methods in a parallel operation with a matched model scheme. This study introduces a fast and parallelizable algorithm to improve the traditional DDM for computing the parallel projection and backprojection operations. Our proposed model has been implemented on a GPU (graphic processing unit) platform and has achieved satisfactory computational efficiency with no approximation. The runtime for the projection and backprojection operations with our model is approximately 4.5 s and 10.5 s per loop, respectively, with an image size of 256×256×256 and 360 projections with a size of 512×512. We compare several general algorithms that have been proposed for maximizing GPU efficiency by using the unmatched projection/backprojection models in a parallel computation. The imaging resolution is not sacrificed and remains accurate during computed tomographic reconstruction. Projected supported by the National High Technology Research and Development Program of China (Grant No. 2012AA011603) and the National Natural Science Foundation of China (Grant No. 61372172).

  8. a Fast Method for Measuring the Similarity Between 3d Model and 3d Point Cloud

    NASA Astrophysics Data System (ADS)

    Zhang, Zongliang; Li, Jonathan; Li, Xin; Lin, Yangbin; Zhang, Shanxin; Wang, Cheng

    2016-06-01

    This paper proposes a fast method for measuring the partial Similarity between 3D Model and 3D point Cloud (SimMC). It is crucial to measure SimMC for many point cloud-related applications such as 3D object retrieval and inverse procedural modelling. In our proposed method, the surface area of model and the Distance from Model to point Cloud (DistMC) are exploited as measurements to calculate SimMC. Here, DistMC is defined as the weighted distance of the distances between points sampled from model and point cloud. Similarly, Distance from point Cloud to Model (DistCM) is defined as the average distance of the distances between points in point cloud and model. In order to reduce huge computational burdens brought by calculation of DistCM in some traditional methods, we define SimMC as the ratio of weighted surface area of model to DistMC. Compared to those traditional SimMC measuring methods that are only able to measure global similarity, our method is capable of measuring partial similarity by employing distance-weighted strategy. Moreover, our method is able to be faster than other partial similarity assessment methods. We demonstrate the superiority of our method both on synthetic data and laser scanning data.

  9. The Adaptive Calibration Model of stress responsivity

    PubMed Central

    Ellis, Bruce J.; Shirtcliff, Elizabeth A.

    2010-01-01

    This paper presents the Adaptive Calibration Model (ACM), an evolutionary-developmental theory of individual differences in the functioning of the stress response system. The stress response system has three main biological functions: (1) to coordinate the organism’s allostatic response to physical and psychosocial challenges; (2) to encode and filter information about the organism’s social and physical environment, mediating the organism’s openness to environmental inputs; and (3) to regulate the organism’s physiology and behavior in a broad range of fitness-relevant areas including defensive behaviors, competitive risk-taking, learning, attachment, affiliation and reproductive functioning. The information encoded by the system during development feeds back on the long-term calibration of the system itself, resulting in adaptive patterns of responsivity and individual differences in behavior. Drawing on evolutionary life history theory, we build a model of the development of stress responsivity across life stages, describe four prototypical responsivity patterns, and discuss the emergence and meaning of sex differences. The ACM extends the theory of biological sensitivity to context (BSC) and provides an integrative framework for future research in the field. PMID:21145350

  10. A phase transition model for the speed-accuracy trade-off in response time experiments.

    PubMed

    Dutilh, Gilles; Wagenmakers, Eric-Jan; Visser, Ingmar; van der Maas, Han L J

    2011-03-01

    Most models of response time (RT) in elementary cognitive tasks implicitly assume that the speed-accuracy trade-off is continuous: When payoffs or instructions gradually increase the level of speed stress, people are assumed to gradually sacrifice response accuracy in exchange for gradual increases in response speed. This trade-off presumably operates over the entire range from accurate but slow responding to fast but chance-level responding (i.e., guessing). In this article, we challenge the assumption of continuity and propose a phase transition model for RTs and accuracy. Analogous to the fast guess model (Ollman, 1966), our model postulates two modes of processing: a guess mode and a stimulus-controlled mode. From catastrophe theory, we derive two important predictions that allow us to test our model against the fast guess model and against the popular class of sequential sampling models. The first prediction--hysteresis in the transitions between guessing and stimulus-controlled behavior--was confirmed in an experiment that gradually changed the reward for speed versus accuracy. The second prediction--bimodal RT distributions--was confirmed in an experiment that required participants to respond in a way that is intermediate between guessing and accurate responding.

  11. Modeling radiation belt electron acceleration by ULF fast mode waves, launched by solar wind dynamic pressure fluctuations

    NASA Astrophysics Data System (ADS)

    Degeling, A. W.; Rankin, R.; Zong, Q.-G.

    2014-11-01

    We investigate the magnetospheric MHD and energetic electron response to a Storm Sudden Commencement (SSC) and subsequent magnetopause buffeting, focusing on an interval following an SSC event on 25 November 2001. We find that the electron flux signatures observed by LANL, Cluster, and GOES spacecraft during this event can largely be reproduced using an advective kinetic model for electron phase space density, using externally prescribed electromagnetic field inputs, (herein described as a "test-kinetic model") with electromagnetic field inputs provided by a 2-D linear ideal MHD model for ULF waves. In particular, we find modulations in electron flux phase shifted by 90° from the local azimuthal ULF wave electric field (Eφ) and a net enhancement in electron flux after 1.5 h for energies between 500 keV and 1.5 MeV near geosynchronous orbit. We also demonstrate that electrons in this energy range satisfy the drift resonance condition for the ULF waves produced by the MHD model. This confirms the conclusions reached by Tan et al. (2011), that the energization process in this case is dominated by drift-resonant interactions between electrons and MHD fast mode waves, produced by fluctuations in solar wind dynamic pressure.

  12. Two-dimensional models of fast rotating early-type stars

    NASA Astrophysics Data System (ADS)

    Rieutord, Michel

    2015-08-01

    Rotation has now become an unavoidable parameter of stellar models, but for most massive or intermediate-mass stars rotation is fast, at least of a significant fraction of the critical angular velocity. Current spherically symmetric models try to cope with this feature of the stars using various approximations, like for instance the so-called shellular rotation usually accompanied with a diffusion that is meant to represent the mixing induced by rotationally generated flows. Such approximations may be justified in the limit of slow rotation where anisotropies and associated flows are weak. However, when rotation is fast, say larger than 50% of the critical velocities the use of a spherically symmetric 1D-model is doubtful. This is not only because of the centrifugal flattening of the star, but also because of the flows that are induced by the baroclinic torque that naturally appears in the radiative envelope of an early-type (rotating) star. These flows face the cylindrical symmetry of the Coriolis force and the spheroidal symmetry of the effective gravity.In this talk I shall present the latest results of the ESTER project that has taken up the challenge of making two-dimensional (axisymmetric) models of stars rotating at any rotation rate. In particular, I will focus on main sequence massive and intermediate-mass stars. I'll show what should be expected in such stars as far as the differential rotation and the associated meridional circulation are concerned, notably the emergence of a Stewartson layer along the tangential cylinder of the core. I'll also indicate what may be inferred about the evolution of an intermediate-mass star at constant angular momentum and how Be stars may form. I shall finally give some comparisons between models and observations of the gravity darkening on some nearby fast rotators as it has been derived from interferometric observations. In passing, I'll also discuss how 2D models can help to recover the fundamental parameters of a star.

  13. Lawyer Proliferation and the Social Responsibility Model.

    ERIC Educational Resources Information Center

    Wines, William A.

    1989-01-01

    Drawing on the model of social responsibility that colleges of business have been teaching, the boom in lawyer education is examined. It is argued that law schools are irresponsible in overselling the benefits of law school graduation, creating a surplus of lawyers whose abilities could be used as well elsewhere. (MSE)

  14. A Ballistic Model of Choice Response Time

    ERIC Educational Resources Information Center

    Brown, Scott; Heathcote, Andrew

    2005-01-01

    Almost all models of response time (RT) use a stochastic accumulation process. To account for the benchmark RT phenomena, researchers have found it necessary to include between-trial variability in the starting point and/or the rate of accumulation, both in linear (R. Ratcliff & J. N. Rouder, 1998) and nonlinear (M. Usher & J. L. McClelland, 2001)…

  15. Fast generation model of high density surface EMG signals in a cylindrical conductor volume.

    PubMed

    Carriou, Vincent; Boudaoud, Sofiane; Laforet, Jeremy; Ayachi, Fouaz Sofiane

    2016-07-01

    In the course of the last decade, fast and qualitative computing power developments have undoubtedly permitted for a better and more realistic modeling of complex physiological processes. Due to this favorable environment, a fast, generic and reliable model for high density surface electromyographic (HD-sEMG) signal generation with a multilayered cylindrical description of the volume conductor is presented in this study. Its main peculiarity lies in the generation of a high resolution potential map over the skin related to active Motor Units (MUs). Indeed, the analytical calculus is fully performed in the frequency domain. HD-sEMG signals are obtained by surfacic numerical integration of the generated high resolution potential map following a variety of electrode shapes. The suggested model is implemented using parallel computing techniques as well as by using an object-oriented approach which is comprehensive enough to be fairly quickly understood, used and potentially upgraded. To illustrate the model abilities, several simulation analyses are put forward in the results section. These simulations have been performed on the same muscle anatomy while varying the number of processes in order to show significant speed improvement. Accuracy of the numerical integration method, illustrating electrode shape diversity, is also investigated in comparison to analytical transfer functions definition. An additional section provides an insight on the volume detection of a circular electrode according to its radius. Furthermore, a large scale simulation is introduced with 300MUs in the muscle and a HD-sEMG electrode grid composed of 16×16 electrodes for three constant isometric contractions in 12s. Finally, advantages and limitations of the proposed model are discussed with a focus on perspective works. PMID:27183535

  16. Fast generation model of high density surface EMG signals in a cylindrical conductor volume.

    PubMed

    Carriou, Vincent; Boudaoud, Sofiane; Laforet, Jeremy; Ayachi, Fouaz Sofiane

    2016-07-01

    In the course of the last decade, fast and qualitative computing power developments have undoubtedly permitted for a better and more realistic modeling of complex physiological processes. Due to this favorable environment, a fast, generic and reliable model for high density surface electromyographic (HD-sEMG) signal generation with a multilayered cylindrical description of the volume conductor is presented in this study. Its main peculiarity lies in the generation of a high resolution potential map over the skin related to active Motor Units (MUs). Indeed, the analytical calculus is fully performed in the frequency domain. HD-sEMG signals are obtained by surfacic numerical integration of the generated high resolution potential map following a variety of electrode shapes. The suggested model is implemented using parallel computing techniques as well as by using an object-oriented approach which is comprehensive enough to be fairly quickly understood, used and potentially upgraded. To illustrate the model abilities, several simulation analyses are put forward in the results section. These simulations have been performed on the same muscle anatomy while varying the number of processes in order to show significant speed improvement. Accuracy of the numerical integration method, illustrating electrode shape diversity, is also investigated in comparison to analytical transfer functions definition. An additional section provides an insight on the volume detection of a circular electrode according to its radius. Furthermore, a large scale simulation is introduced with 300MUs in the muscle and a HD-sEMG electrode grid composed of 16×16 electrodes for three constant isometric contractions in 12s. Finally, advantages and limitations of the proposed model are discussed with a focus on perspective works.

  17. Modeling the Zeeman effect in high-altitude SSMIS channels for numerical weather prediction profiles: comparing a fast model and a line-by-line model

    NASA Astrophysics Data System (ADS)

    Larsson, Richard; Milz, Mathias; Rayer, Peter; Saunders, Roger; Bell, William; Booton, Anna; Buehler, Stefan A.; Eriksson, Patrick; John, Viju O.

    2016-03-01

    We present a comparison of a reference and a fast radiative transfer model using numerical weather prediction profiles for the Zeeman-affected high-altitude Special Sensor Microwave Imager/Sounder channels 19-22. We find that the models agree well for channels 21 and 22 compared to the channels' system noise temperatures (1.9 and 1.3 K, respectively) and the expected profile errors at the affected altitudes (estimated to be around 5 K). For channel 22 there is a 0.5 K average difference between the models, with a standard deviation of 0.24 K for the full set of atmospheric profiles. Concerning the same channel, there is 1.2 K on average between the fast model and the sensor measurement, with 1.4 K standard deviation. For channel 21 there is a 0.9 K average difference between the models, with a standard deviation of 0.56 K. Regarding the same channel, there is 1.3 K on average between the fast model and the sensor measurement, with 2.4 K standard deviation. We consider the relatively small model differences as a validation of the fast Zeeman effect scheme for these channels. Both channels 19 and 20 have smaller average differences between the models (at below 0.2 K) and smaller standard deviations (at below 0.4 K) when both models use a two-dimensional magnetic field profile. However, when the reference model is switched to using a full three-dimensional magnetic field profile, the standard deviation to the fast model is increased to almost 2 K due to viewing geometry dependencies, causing up to ±7 K differences near the equator. The average differences between the two models remain small despite changing magnetic field configurations. We are unable to compare channels 19 and 20 to sensor measurements due to limited altitude range of the numerical weather prediction profiles. We recommended that numerical weather prediction software using the fast model takes the available fast Zeeman scheme into account for data assimilation of the affected sensor channels to

  18. Testing Linear Models for Ability Parameters in Item Response Models

    ERIC Educational Resources Information Center

    Glas, Cees A. W.; Hendrawan, Irene

    2005-01-01

    Methods for testing hypotheses concerning the regression parameters in linear models for the latent person parameters in item response models are presented. Three tests are outlined: A likelihood ratio test, a Lagrange multiplier test and a Wald test. The tests are derived in a marginal maximum likelihood framework. They are explicitly formulated…

  19. A CFD model for biomass fast pyrolysis in fluidized-bed reactors

    NASA Astrophysics Data System (ADS)

    Xue, Qingluan; Heindel, T. J.; Fox, R. O.

    2010-11-01

    A numerical study is conducted to evaluate the performance and optimal operating conditions of fluidized-bed reactors for fast pyrolysis of biomass to bio-oil. A comprehensive CFD model, coupling a pyrolysis kinetic model with a detailed hydrodynamics model, is developed. A lumped kinetic model is applied to describe the pyrolysis of biomass particles. Variable particle porosity is used to account for the evolution of particle physical properties. The kinetic scheme includes primary decomposition and secondary cracking of tar. Biomass is composed of reference components: cellulose, hemicellulose, and lignin. Products are categorized into groups: gaseous, tar vapor, and solid char. The particle kinetic processes and their interaction with the reactive gas phase are modeled with a multi-fluid model derived from the kinetic theory of granular flow. The gas, sand and biomass constitute three continuum phases coupled by the interphase source terms. The model is applied to investigate the effect of operating conditions on the tar yield in a fluidized-bed reactor. The influence of various parameters on tar yield, including operating temperature and others are investigated. Predicted optimal conditions for tar yield and scale-up of the reactor are discussed.

  20. Modeling of nonlinear physiological systems with fast and slow dynamics. II. Application to cerebral autoregulation.

    PubMed

    Mitsis, G D; Zhang, R; Levine, B D; Marmarelis, V Z

    2002-04-01

    Dynamic autoregulation of cerebral hemodynamics in healthy humans is studied using the novel methodology of the Laguerre-Volterra network for systems with fast and slow dynamics (Mitsis, G. D., and V. Z. Marmarelis, Ann. Biomed. Eng. 30:272-281, 2002). Since cerebral autoregulation is mediated by various physiological mechanisms with significantly different time constants, it is used to demonstrate the efficacy of the new method. Results are presented in the time and frequency domains and reveal that cerebral autoregulation is a nonlinear and dynamic (frequency-dependent) system with considerable nonstationarities. Quantification of the latter reveals greater variability in specific frequency bands for each subject in the low and middle frequency range (below 0.1 Hz). The nonlinear dynamics are prominent also in the low and middle frequency ranges, where the frequency response of the system exhibits reduced gain. PMID:12086006

  1. Fast response double series resonant high-voltage DC-DC converter

    NASA Astrophysics Data System (ADS)

    Lee, S. S.; Iqbal, S.; Kamarol, M.

    2012-10-01

    In this paper, a novel double series resonant high-voltage dc-dc converter with dual-mode pulse frequency modulation (PFM) control scheme is proposed. The proposed topology consists of two series resonant tanks and hence two resonant currents flow in each switching period. Moreover, it consists of two high-voltage transformer with the leakage inductances are absorbed as resonant inductor in the series resonant tanks. The secondary output of both transformers are rectified and mixed before supplying to load. In the resonant mode operation, the series resonant tanks are energized alternately by controlling two Insulated Gate Bipolar Transistor (IGBT) switches with pulse frequency modulation (PFM). This topology operates in discontinuous conduction mode (DCM) with all IGBT switches operating in zero current switching (ZCS) condition and hence no switching loss occurs. To achieve fast rise in output voltage, a dual-mode PFM control during start-up of the converter is proposed. In this operation, the inverter is started at a high switching frequency and as the output voltage reaches 90% of the target value, the switching frequency is reduced to a value which corresponds to the target output voltage. This can effectively reduce the rise time of the output voltage and prevent overshoot. Experimental results collected from a 100-W laboratory prototype are presented to verify the effectiveness of the proposed system.

  2. Fast Modeling of Binding Affinities by Means of Superposing Significant Interaction Rules (SSIR) Method

    PubMed Central

    Besalú, Emili

    2016-01-01

    The Superposing Significant Interaction Rules (SSIR) method is described. It is a general combinatorial and symbolic procedure able to rank compounds belonging to combinatorial analogue series. The procedure generates structure-activity relationship (SAR) models and also serves as an inverse SAR tool. The method is fast and can deal with large databases. SSIR operates from statistical significances calculated from the available library of compounds and according to the previously attached molecular labels of interest or non-interest. The required symbolic codification allows dealing with almost any combinatorial data set, even in a confidential manner, if desired. The application example categorizes molecules as binding or non-binding, and consensus ranking SAR models are generated from training and two distinct cross-validation methods: leave-one-out and balanced leave-two-out (BL2O), the latter being suited for the treatment of binary properties. PMID:27240346

  3. Fast and accurate low-dimensional reduction of biophysically detailed neuron models.

    PubMed

    Marasco, Addolorata; Limongiello, Alessandro; Migliore, Michele

    2012-01-01

    Realistic modeling of neurons are quite successful in complementing traditional experimental techniques. However, their networks require a computational power beyond the capabilities of current supercomputers, and the methods used so far to reduce their complexity do not take into account the key features of the cells nor critical physiological properties. Here we introduce a new, automatic and fast method to map realistic neurons into equivalent reduced models running up to > 40 times faster while maintaining a very high accuracy of the membrane potential dynamics during synaptic inputs, and a direct link with experimental observables. The mapping of arbitrary sets of synaptic inputs, without additional fine tuning, would also allow the convenient and efficient implementation of a new generation of large-scale simulations of brain regions reproducing the biological variability observed in real neurons, with unprecedented advances to understand higher brain functions. PMID:23226594

  4. Comparisons of Crosswind Velocity Profile Estimates Used in Fast-Time Wake Vortex Prediction Models

    NASA Technical Reports Server (NTRS)

    Pruis, Mathew J.; Delisi, Donald P.; Ahmad, Nashat N.

    2011-01-01

    Five methods for estimating crosswind profiles used in fast-time wake vortex prediction models are compared in this study. Previous investigations have shown that temporal and spatial variations in the crosswind vertical profile have a large impact on the transport and time evolution of the trailing vortex pair. The most important crosswind parameters are the magnitude of the crosswind and the gradient in the crosswind shear. It is known that pulsed and continuous wave lidar measurements can provide good estimates of the wind profile in the vicinity of airports. In this study comparisons are made between estimates of the crosswind profiles from a priori information on the trajectory of the vortex pair as well as crosswind profiles derived from different sensors and a regional numerical weather prediction model.

  5. Model for collisional fast ion diffusion into Tokamak Fusion Test Reactor loss cone

    SciTech Connect

    Chang, C.S. |; Zweben, S.J.; Schivell, J.; Budny, R.; Scott, S.

    1994-08-01

    An analytic model is developed to estimate the classical pitch angle scattering loss of energetic fusion product ions into prompt loss orbits in a tokamak geometry. The result is applied to alpha particles produced by deutrium-tritium fusion reactions in a plasma condition relevant to Tokamak Fusion Test Reactor (TFTR). A poloidal angular distribution of collisional fast ion loss at the first wall is obtained and the numerical result from the TRANSP code is discussed. The present model includes the effect that the prompt loss boundary moves away from the slowing-down path due to reduction in banana thickness, which enables us to understand, for the first time. the dependence of the collisional loss rate on Z{sub eff}.

  6. Fast and accurate low-dimensional reduction of biophysically detailed neuron models.

    PubMed

    Marasco, Addolorata; Limongiello, Alessandro; Migliore, Michele

    2012-01-01

    Realistic modeling of neurons are quite successful in complementing traditional experimental techniques. However, their networks require a computational power beyond the capabilities of current supercomputers, and the methods used so far to reduce their complexity do not take into account the key features of the cells nor critical physiological properties. Here we introduce a new, automatic and fast method to map realistic neurons into equivalent reduced models running up to > 40 times faster while maintaining a very high accuracy of the membrane potential dynamics during synaptic inputs, and a direct link with experimental observables. The mapping of arbitrary sets of synaptic inputs, without additional fine tuning, would also allow the convenient and efficient implementation of a new generation of large-scale simulations of brain regions reproducing the biological variability observed in real neurons, with unprecedented advances to understand higher brain functions.

  7. Particle-In-Cell modeling of Fast Ignition experiments on the Titan Laser

    NASA Astrophysics Data System (ADS)

    Link, Anthony; Akli, K. U.; Beg, F.; Chen, C. D.; Davies, J. R.; Freeman, R. R.; Kemp, G. E.; Li, K.; McLean, H. S.; Morace, A.; Patel, P. K.; Schumacher, D. W.; Sorokovikova, A. V.; Stephens, R.; Streeter, M. J. V.; Wertepny, D.; Westhover, B.

    2012-10-01

    We report on particle-in-cell-modeling (PIC) of fast ignition experiments conducted on the Titan laser. The Titan laser was used to irradiate multilayer planar targets at intensities greater than 10^20 Wcm-2 to diagnose the laser to electron coupling, electron beam divergence, and energy spectrum of the hot electrons at relativistic intensities. Hot electron beam properties were inferred through buried fluors, escaping electrons and bremsstrahlung measurements. The PIC simulations of the experiment were conducted in two stages: a high resolution laser plasma interaction (LPI) simulation using measured on shot laser parameters but with a subscale target; and a lower resolution transport simulation containing the full scale multilayer target. The transport simulation utilized the electron source based on the output of the LPI simulation and included necessary models to simulate the experimental diagnostics. Comparison of the predicted electron source properties and the experimental data will be presented.

  8. Mesoscale atmospheric modeling for emergency response

    SciTech Connect

    O'Steen, B.L.; Fast, J.D.

    1992-01-01

    Atmospheric transport models for emergency response have traditionally utilized meteorological fields interpolated from sparse data to predict contaminant transport. Often these fields are adjusted to satisfy constraints derived from the governing equations of geophysical fluid dynamics, e.g. mass continuity. Gaussian concentration distributions or stochastic models are then used to represent turbulent diffusion of a contaminant in the diagnosed meteorological fields. The popularity of these models derives from their relative simplicity, ability to make reasonable short-term predictions and, most important, execution speed. The ability to generate a transport prediction for an accidental release from the Savannah River Site in a time frame which will allow protective action to be taken is essential in an emergency response operation.

  9. Mesoscale atmospheric modeling for emergency response

    SciTech Connect

    O`Steen, B.L.; Fast, J.D.

    1992-12-31

    Atmospheric transport models for emergency response have traditionally utilized meteorological fields interpolated from sparse data to predict contaminant transport. Often these fields are adjusted to satisfy constraints derived from the governing equations of geophysical fluid dynamics, e.g. mass continuity. Gaussian concentration distributions or stochastic models are then used to represent turbulent diffusion of a contaminant in the diagnosed meteorological fields. The popularity of these models derives from their relative simplicity, ability to make reasonable short-term predictions and, most important, execution speed. The ability to generate a transport prediction for an accidental release from the Savannah River Site in a time frame which will allow protective action to be taken is essential in an emergency response operation.

  10. Fast responsive and highly efficient optical upconverter based on phosphorescent OLED.

    PubMed

    Chu, Xinbo; Guan, Min; Niu, Litao; Zeng, Yiping; Li, Yiyang; Zhang, Yang; Zhu, Zhanping; Wang, Baoqiang

    2014-11-12

    In this work, an organic-inorganic hybrid optical upconverter that can convert irradiated 980 nm IR light to 510 nm green phosphorescence sensitively was fabricated and studied. fac-Tris(2-phenylpyridine) iridium (Ir(ppy)3) doped 4,4'-bis(N-carbazolyl)-1,1'-biphenyl (CBP) was used as emitting layer in the phosphorescent organic light-emitting diode (OLED) unit. The upconverter using a phosphorescent OLED as display unit can achieve a higher upconversion efficiency and a low power consumption when compared with the one using fluorescent. An upconversion efficiency of 4.8% can be achieved for phosphorescent device at 15 V, much higher than that of fluorescent one (2.0%). The upconverter's transient optical and electric response to IR pulse were also investigated for the first time. The response time was found to be influenced by IR intensity and applied voltage. It has a response time as short as 60 μs. The rapid response property of the upconverter makes it feasible to be applied to high-speed IR imaging systems.

  11. Measurements of response functions of EJ-299-33A plastic scintillator for fast neutrons

    NASA Astrophysics Data System (ADS)

    Hartman, J.; Barzilov, A.; Peters, E. E.; Yates, S. W.

    2015-12-01

    Monoenergetic neutron response functions were measured for an EJ-299-33A plastic scintillator. The 7-MV Van de Graaff accelerator at the University of Kentucky Accelerator Laboratory was used to produce proton and deuteron beams for reactions with gaseous tritium and deuterium targets, yielding monoenergetic neutrons by means of the 3H(p,n)3He, 2H(d,n)3He, and 3H(d,n)4He reactions. The neutron energy was selected by tuning the charged-particle's energy and using the angular dependence of the neutron emission. The resulting response functions were measured for 0.1-MeV steps in neutron energy from 0.1 MeV to 8.2 MeV and from 12.2 MeV to 20.2 MeV. Experimental data were processed using a procedure for digital pulse-shape discrimination, which allowed characterization of the response functions of the plastic scintillator to neutrons only. The response functions are intended for use in neutron spectrum unfolding methods.

  12. High-efficiency and fast-response tunable phase grating using a blue phase liquid crystal.

    PubMed

    Yan, Jin; Li, Yan; Wu, Shin-Tson

    2011-04-15

    We demonstrate a tunable phase grating using a polymer-stabilized blue phase liquid crystal. Because of the electric-field-induced rectangularlike phase profile, a high diffraction efficiency of 40% is achieved. Moreover, this device shows submillisecond response time. The proposed tunable phase grating holds great potential for photonics and display applications. PMID:21499371

  13. Study of Spurious Response near the Fast Shear Wave in SiO2/Al/LiNbO3 Structure

    NASA Astrophysics Data System (ADS)

    Goto, Rei; Fujiwara, Joji; Nakamura, Hiroyuki; Tsurunari, Tetsuya; Nakanishi, Hidekazu; Hamaoka, Yosuke

    2013-07-01

    The shear horizontal (SH) mode on the SiO2/Al/LiNbO3 structure is studied because of its sufficient electromechanical coupling factor (K2) and good temperature coefficient of frequency (TCF). The authors proposed a method of suppressing the spurious response of the Rayleigh mode and the transverse mode for narrow duplex gap applications. For the narrow duplex gap application, the SiO2 thickness must be increased to achieve good TCF characteristics. However, another spurious response appears near the fast shear wave with increasing SiO2 thickness. In this paper, we discuss the suppression mechanism of the spurious response near the fast shear wave.

  14. Modeling the mechanical response of PBX 9501

    SciTech Connect

    Ragaswamy, Partha; Lewis, Matthew W; Liu, Cheng; Thompson, Darla G

    2010-01-01

    An engineering overview of the mechanical response of Plastic-Bonded eXplosives (PBXs), specifically PBX 9501, will be provided with emphasis on observed mechanisms associated with different types of mechanical testing. Mechanical tests in the form of uniaxial tension, compression, cyclic loading, creep (compression and tension), and Hopkinson bar show strain rate and temperature dependence. A range of mechanical behavior is observed which includes small strain recoverable response in the form of viscoelasticity; change in stiffness and softening beyond peak strength due to damage in the form microcracks, debonding, void formation and the growth of existing voids; inelastic response in the form of irrecoverable strain as shown in cyclic tests, and viscoelastic creep combined with plastic response as demonstrated in creep and recovery tests. The main focus of this paper is to elucidate the challenges and issues involved in modeling the mechanical behavior of PBXs for simulating thermo-mechanical responses in engineering components. Examples of validation of a constitutive material model based on a few of the observed mechanisms will be demonstrated against three point bending, split Hopkinson pressure bar and Brazilian disk geometry.

  15. Phase space effects on fast ion distribution function modeling in tokamaks

    DOE PAGES

    Podesta, M.; Gorelenkova, M.; Fredrickson, E. D.; Gorelenkov, N. N.; White, R. B.

    2016-04-14

    Here, integrated simulations of tokamak discharges typically rely on classical physics to model energetic particle (EP) dynamics. However, there are numerous cases in which energetic particles can suffer additional transport that is not classical in nature. Examples include transport by applied 3D magnetic perturbations and, more notably, by plasma instabilities. Focusing on the effects of instabilities,ad-hocmodels can empirically reproduce increased transport, but the choice of transport coefficients is usually somehow arbitrary. New approaches based on physics-based reduced models are being developed to address those issues in a simplified way, while retaining a more correct treatment of resonant wave-particle interactions. Themore » kick model implemented in the tokamaktransport code TRANSP is an example of such reduced models. It includes modifications of the EP distribution by instabilities in real and velocity space, retaining correlations between transport in energy and space typical of resonant EP transport. The relevance of EP phase space modifications by instabilities is first discussed in terms of predicted fast ion distribution. Results are compared with those from a simple, ad-hoc diffusive model. It is then shown that the phase-space resolved model can also provide additional insight into important issues such as internal consistency of the simulations and mode stability through the analysis of the power exchanged between energetic particles and the instabilities.« less

  16. Fast-response optical and near-infrared GRB science with RATIR and RIMAS

    NASA Astrophysics Data System (ADS)

    Capone, John; RIMAS Collaboration, RATIR project Team

    2016-01-01

    As the Universe's most luminous transient events, long gamma-ray bursts (GRBs) are observed at cosmological distances. The afterglow emission generated by the burst's interaction with the surrounding medium presents the opportunity to study the local environment, as well as intervening systems. The transient nature of these events requires observations starting within minutes of the GRB to maximize the scientific opportunities.This dissertation work comprises efforts to advance the field with a new instrument, the Rapid Infrared Imager and Spectrograph (RIMAS). The optical design is complicated by the broad band coverage (0.97 to 2.39 microns) and the necessity of transmissive optics due to space and weight limitations on the telescope. Additionally, the entire optical system must be cooled to cryogenic temperatures to decrease the background from thermal emission. The completed instrument will be permanently installed on Lowell Observatory's new 4.3 meter Discovery Channel Telescope (DCT) located in Happy Jack, Arizona. The fast slew time of the telescope, combined with the instrument's ability to image in two bands simultaneously and switch to spectroscopic configurations in under a minute will allow observers to obtain photometric data within minutes and spectra within ~ ten minutes.In addition to instrumentation work on RIMAS's optics, early time photometric light curves have been studied primarily using data from the Reionization and Transients Infrared/Optical Project (RATIR). Early time photometric data in six optical and near-infrared (NIR) bands has allowed a study of color evolution in the early to late time SEDs. This study probes possible impacts of the GRB on the local medium as well as intrinsic changes in the afterglow emission.This work is made possible by the RATIR and RIMAS collaborations as well as financial support by the NSF.

  17. Fast responses of bacterial membranes to virus adsorption: a fluorescence study.

    PubMed Central

    Bayer, M E; Bayer, M H

    1981-01-01

    After collision with their host cells, virus particles may remain mobile on cell surfaces until they become attached at firm binding sites. We propose that a virion will arrive within a typical median time at such a site, generating a membrane signal such as an increased membrane fluorescence in cells labeled with the voltage-sensitive dyes 8-anilino-1-naphthalene-sulfonate (Mg-salt) (ANS), N-phenylnaphthylamine (NPA), or 3,3'-dipentyl-2,2'-oxacarbocyanine (di-O-C5[3]). We found that the time span between virus adsorption and fluorescence response varies widely among phages and also depends on bacterial strain, metabolic state, and type of dye. di-O-C5[3]-labeled cells react within 1 sec to uncouplers such as carbonyl cyanide m-chlorophenylhydrazone (CCCP). Cells labeled with ANS and NPA react to CCCP in 4-6 sec. Bacteriophages T4, T5, chi, and BF23, added to ANS-labeled cells, change the fluorescence in 9-15 sec. T-even ghosts cause a response at identical times. Baseplate-defective phage mutant T412- and isolated adsorption organelles of smaller viruses fail to cause an effect. di-O-C5[3]-labeled cells respond to T4 at a multiplicity of infection greater than or equal to 40 within 1 sec. A longer time (8 sec) is required at lower multiplicities. The receptor-degrading phages epsilon 15, epsilon 34, c 341, and K29 need the longest time (1 min for ANS) to cause a fluorescence increase. We suggest that the delayed fluorescence response is concomitant with the surface "walk" of the virion, which is terminated at an injection site. T4 tail sheath contraction coincides with the onset of the membrane fluorescence response. PMID:7029540

  18. 3D fast wavelet network model-assisted 3D face recognition

    NASA Astrophysics Data System (ADS)

    Said, Salwa; Jemai, Olfa; Zaied, Mourad; Ben Amar, Chokri

    2015-12-01

    In last years, the emergence of 3D shape in face recognition is due to its robustness to pose and illumination changes. These attractive benefits are not all the challenges to achieve satisfactory recognition rate. Other challenges such as facial expressions and computing time of matching algorithms remain to be explored. In this context, we propose our 3D face recognition approach using 3D wavelet networks. Our approach contains two stages: learning stage and recognition stage. For the training we propose a novel algorithm based on 3D fast wavelet transform. From 3D coordinates of the face (x,y,z), we proceed to voxelization to get a 3D volume which will be decomposed by 3D fast wavelet transform and modeled after that with a wavelet network, then their associated weights are considered as vector features to represent each training face . For the recognition stage, an unknown identity face is projected on all the training WN to obtain a new vector features after every projection. A similarity score is computed between the old and the obtained vector features. To show the efficiency of our approach, experimental results were performed on all the FRGC v.2 benchmark.

  19. Comparative Analyses of Two Extremely Fast CMEs Induced Shocks using A H3DMHD Model

    NASA Astrophysics Data System (ADS)

    Wu, S. T.; Wu, C. C.; Liou, K.; Dryer, Ph D., M.; Plunkett, S. P.

    2015-12-01

    During the last two decades, spacecraft recorded several extremely fast Coronal Mass Ejections (CMEs) which have resulted in severe geomagnetic storms. Here, we will report results from a comparative study of two extremely fast CME events: one on 29 October 2003 (Halloween 2003 epoch) and the other on 23 July 2012. Both shock events reached 1 AU within ~20 hours. We employed a global three-dimensional (3D) magnetohydrodynamics (MHD) simulation model (H3DMHD, Wu et al. 2007, JGR) to study these two events and compared the results with observations (e.g., 1 AU in-situ data, and coronal images from SOHO/LASCO or STEREO/ SECCHI). It was found that: (i) The peak temperature, velocity, and density of the solar wind for the shock/ICME event are 2 x 107 K, 2500 km s-1, and 35 cm-3, respectively. (ii) The peaks of magnetic field (B) are ~60 and 110 nT for the event on 29 October 2003 and 23 July 2012, respectively. Solar wind densities behind the shocks are extremely low which are due to rarefaction of the interplanetary shocks' propagation. We will discuss this issue in the presentation. Simulations are vastly improved and forecasting arrival times should be done as noted in real time by Zhou and Dryer (Space Weather Quarterly, 2014) review, but CME and B therein is still a major challenge for storm prediction.

  20. Note: Fabrication of a fast-response and user-friendly environmental chamber for atomic force microscopes

    SciTech Connect

    Ji, Yanfeng; Hui, Fei; Shi, Yuanyuan; Han, Tingting; Song, Xiaoxue; Pan, Chengbin; Lanza, Mario

    2015-10-15

    The atomic force microscope is one of the most widespread tools in science, but many suppliers do not provide a competitive solution to make experiments in controlled atmospheres. Here, we provide a solution to this problem by fabricating a fast-response and user-friendly environmental chamber. We corroborate the correct functioning of the chamber by studying the formation of local anodic oxidation on a silicon sample (biased under opposite polarities), an effect that can be suppressed by measuring in a dry nitrogen atmosphere. The usefulness of this chamber goes beyond the example here presented, and it could be used in many other fields of science, including physics, mechanics, microelectronics, nanotechnology, medicine, and biology.

  1. BODIPY fluorescent chemosensor for Cu2+ detection and its applications in living cells: fast response and high sensitivity.

    PubMed

    Quan, Li; Sun, Tingting; Lin, Wenhai; Guan, Xingang; Zheng, Min; Xie, Zhigang; Jing, Xiabin

    2014-05-01

    Copper is an essential trace element for the proper functioning of organ and metabolic process in humans. However, both its excess and deficiency in the body can result in adverse health effects. A BODIPY containing 2,2'-bipyridyl group was synthesized and used as a fluorescent chemodosimeter for selective Cu2+ detection in mild condition. This BODIPY shows fast response (~1 min) and high sensitivity for Cu2+ in aqueous solution due to the photoinduced electron transfer from the excited state of fluorophore to the bipyridyl unit complexed to Cu2+. The fluorescence quenching mechanism revealed by MALDI-TOF Mass spectra showed one Cu2+ could coordinate with two BODIPY molecules, and this coordination is reversible. This simple BODIPY dyes also could be used for sensing the Cu2+ in living cell. This work contributes to extend the potential applications of BODIPY to the biological and environmental areas. PMID:24522344

  2. Note: Fabrication of a fast-response and user-friendly environmental chamber for atomic force microscopes.

    PubMed

    Ji, Yanfeng; Hui, Fei; Shi, Yuanyuan; Han, Tingting; Song, Xiaoxue; Pan, Chengbin; Lanza, Mario

    2015-10-01

    The atomic force microscope is one of the most widespread tools in science, but many suppliers do not provide a competitive solution to make experiments in controlled atmospheres. Here, we provide a solution to this problem by fabricating a fast-response and user-friendly environmental chamber. We corroborate the correct functioning of the chamber by studying the formation of local anodic oxidation on a silicon sample (biased under opposite polarities), an effect that can be suppressed by measuring in a dry nitrogen atmosphere. The usefulness of this chamber goes beyond the example here presented, and it could be used in many other fields of science, including physics, mechanics, microelectronics, nanotechnology, medicine, and biology.

  3. FastGGM: An Efficient Algorithm for the Inference of Gaussian Graphical Model in Biological Networks

    PubMed Central

    Ding, Ying; Fang, Zhou; Sun, Zhe; MacDonald, Matthew L.; Sweet, Robert A.; Wang, Jieru; Chen, Wei

    2016-01-01

    Biological networks provide additional information for the analysis of human diseases, beyond the traditional analysis that focuses on single variables. Gaussian graphical model (GGM), a probability model that characterizes the conditional dependence structure of a set of random variables by a graph, has wide applications in the analysis of biological networks, such as inferring interaction or comparing differential networks. However, existing approaches are either not statistically rigorous or are inefficient for high-dimensional data that include tens of thousands of variables for making inference. In this study, we propose an efficient algorithm to implement the estimation of GGM and obtain p-value and confidence interval for each edge in the graph, based on a recent proposal by Ren et al., 2015. Through simulation studies, we demonstrate that the algorithm is faster by several orders of magnitude than the current implemented algorithm for Ren et al. without losing any accuracy. Then, we apply our algorithm to two real data sets: transcriptomic data from a study of childhood asthma and proteomic data from a study of Alzheimer’s disease. We estimate the global gene or protein interaction networks for the disease and healthy samples. The resulting networks reveal interesting interactions and the differential networks between cases and controls show functional relevance to the diseases. In conclusion, we provide a computationally fast algorithm to implement a statistically sound procedure for constructing Gaussian graphical model and making inference with high-dimensional biological data. The algorithm has been implemented in an R package named “FastGGM”. PMID:26872036

  4. 3ARM: A Fast, Accurate Radiative Transfer Model for Use in Climate Models

    NASA Technical Reports Server (NTRS)

    Bergstrom, R. W.; Kinne, S.; Sokolik, I. N.; Toon, O. B.; Mlawer, E. J.; Clough, S. A.; Ackerman, T. P.; Mather, J.

    1996-01-01

    A new radiative transfer model combining the efforts of three groups of researchers is discussed. The model accurately computes radiative transfer in a inhomogeneous absorbing, scattering and emitting atmospheres. As an illustration of the model, results are shown for the effects of dust on the thermal radiation.

  5. 3ARM: A Fast, Accurate Radiative Transfer Model for use in Climate Models

    NASA Technical Reports Server (NTRS)

    Bergstrom, R. W.; Kinne, S.; Sokolik, I. N.; Toon, O. B.; Mlawer, E. J.; Clough, S. A.; Ackerman, T. P.; Mather, J.

    1996-01-01

    A new radiative transfer model combining the efforts of three groups of researchers is discussed. The model accurately computes radiative transfer in a inhomogeneous absorbing, scattering and emitting atmospheres. As an illustration of the model, results are shown for the effects of dust on the thermal radiation.

  6. Parsimonious Hydrologic and Nitrate Response Models For Silver Springs, Florida

    NASA Astrophysics Data System (ADS)

    Klammler, Harald; Yaquian-Luna, Jose Antonio; Jawitz, James W.; Annable, Michael D.; Hatfield, Kirk

    2014-05-01

    Silver Springs with an approximate discharge of 25 m3/sec is one of Florida's first magnitude springs and among the largest springs worldwide. Its 2500-km2 springshed overlies the mostly unconfined Upper Floridan Aquifer. The aquifer is approximately 100 m thick and predominantly consists of porous, fractured and cavernous limestone, which leads to excellent surface drainage properties (no major stream network other than Silver Springs run) and complex groundwater flow patterns through both rock matrix and fast conduits. Over the past few decades, discharge from Silver Springs has been observed to slowly but continuously decline, while nitrate concentrations in the spring water have enormously increased from a background level of 0.05 mg/l to over 1 mg/l. In combination with concurrent increases in algae growth and turbidity, for example, and despite an otherwise relatively stable water quality, this has given rise to concerns about the ecological equilibrium in and near the spring run as well as possible impacts on tourism. The purpose of the present work is to elaborate parsimonious lumped parameter models that may be used by resource managers for evaluating the springshed's hydrologic and nitrate transport responses. Instead of attempting to explicitly consider the complex hydrogeologic features of the aquifer in a typically numerical and / or stochastic approach, we use a transfer function approach wherein input signals (i.e., time series of groundwater recharge and nitrate loading) are transformed into output signals (i.e., time series of spring discharge and spring nitrate concentrations) by some linear and time-invariant law. The dynamic response types and parameters are inferred from comparing input and output time series in frequency domain (e.g., after Fourier transformation). Results are converted into impulse (or step) response functions, which describe at what time and to what magnitude a unitary change in input manifests at the output. For the

  7. Population-expression models of immune response

    NASA Astrophysics Data System (ADS)

    Stromberg, Sean P.; Antia, Rustom; Nemenman, Ilya

    2013-06-01

    The immune response to a pathogen has two basic features. The first is the expansion of a few pathogen-specific cells to form a population large enough to control the pathogen. The second is the process of differentiation of cells from an initial naive phenotype to an effector phenotype which controls the pathogen, and subsequently to a memory phenotype that is maintained and responsible for long-term protection. The expansion and the differentiation have been considered largely independently. Changes in cell populations are typically described using ecologically based ordinary differential equation models. In contrast, differentiation of single cells is studied within systems biology and is frequently modeled by considering changes in gene and protein expression in individual cells. Recent advances in experimental systems biology make available for the first time data to allow the coupling of population and high dimensional expression data of immune cells during infections. Here we describe and develop population-expression models which integrate these two processes into systems biology on the multicellular level. When translated into mathematical equations, these models result in non-conservative, non-local advection-diffusion equations. We describe situations where the population-expression approach can make correct inference from data while previous modeling approaches based on common simplifying assumptions would fail. We also explore how model reduction techniques can be used to build population-expression models, minimizing the complexity of the model while keeping the essential features of the system. While we consider problems in immunology in this paper, we expect population-expression models to be more broadly applicable.

  8. Fast evolving pair-instability supernova models: Evolution, explosion, light curves

    NASA Astrophysics Data System (ADS)

    Kozyreva, Alexandra; Gilmer, Matthew; Hirschi, Raphael; Fröhlich, Carla; Blinnikov, Sergey; Wollaeger, Ryan T.; Noebauer, Ulrich M.; van Rossum, Daniel R.; Heger, Alexander; Even, Wesley P.; Waldman, Roni; Tolstov, Alexey; Chatzopoulos, Emmanouil; Sorokina, Elena

    2016-10-01

    With an increasing number of superluminous supernovae (SLSNe) discovered the question of their origin remains open and causes heated debates in the supernova community. Currently, there are three proposed mechanisms for SLSNe: (1) pair-instability supernovae (PISN), (2) magnetar-driven supernovae, and (3) models in which the supernova ejecta interacts with a circumstellar material ejected before the explosion. Based on current observations of SLSNe, the PISN origin has been disfavoured for a number of reasons. Many PISN models provide overly broad light curves and too reddened spectra, because of massive ejecta and a high amount of nickel. In the current study we re-examine PISN properties using progenitor models computed with the GENEC code. We calculate supernova explosions with FLASH and light curve evolution with the radiation hydrodynamics code STELLA. We find that high-mass models (200 M⊙ and 250 M⊙) at relatively high metallicity (Z = 0.001) do not retain hydrogen in the outer layers and produce relatively fast evolving PISNe Type I and might be suitable to explain some SLSNe. We also investigate uncertainties in light curve modelling due to codes, opacities, the nickel-bubble effect and progenitor structure and composition.

  9. Realistic Modeling of SDO/AIA-discovered Coronal Fast MHD Wave Trains in Active Regions

    NASA Astrophysics Data System (ADS)

    Ofman, Leon; Liu, Wei

    2016-05-01

    High-resolution EUV observations by space telescopes have provided plenty of evidence for coronal MHD waves in active regions. In particular, SDO/AIA discovered quasi-periodic, fast-mode propagating MHD wave trains (QFPs), which can propagate at speeds of ~1000 km/s perpendicular to the magnetic field. Such waves can provide information on the energy release of their associated flares and the magnetized plasma structure of the active regions. Before we can use these waves as tools for coronal seismology, 3D MHD modeling is required for disentangling observational ambiguities and improving the diagnostic accuracy. We present new results of observationally contained models of QFPs using our recently upgraded radiative, thermally conductive, visco-resistive 3D MHD code. The waves are excited by time-depended boundary conditions constrained by the spatial (localized) and quasi-periodic temporal evolution of a C-class flare typically associated with QFPs. We investigate the excitation, propagation, and damping of the waves for a range of key model parameters, such as the background temperature, density, magnetic field structure, and the location of the flaring site within the active region. We synthesize EUV intensities in multiple AIA channels and then obtain the model parameters that best reproduce the properties of observed QFPs. We discuss the implications of our model results for the seismological application of QFPs and for understanding the dynamics of their associated flares.

  10. Calcium-activated force responses in fast- and slow-twitch skinned muscle fibres of the rat at different temperatures.

    PubMed Central

    Stephenson, D G; Williams, D A

    1981-01-01

    1. Force responses from mechanically skinned fibres of rat skeletal muscles (extensor digitorum longus and soleus) were measured at different temperatures in the range 3-35 degrees C following sudden changes in Ca2+ concentration in the preparations. 2. At all temperatures there were characteristic differences between the slow- and fast-twitch muscle fibres with respect to the relative steady-state force-[Ca2+] relation: such as a lower [Ca2+] threshold for activation and a less steep force-pCa curve in slow-twitch muscle fibres. 3. At 3-5 degrees C the force changes in both types of muscle fibres lagged considerably behind the estimated changes in [Ca2+] within the preparations and this enabled us to perform a comparative analysis of the Ca2+ kinetics in the process of force development in both muscle fibre types. This analysis suggest that two and six Ca2+ ions are involved in the regulatory unit for contraction of slow- and fast-twitch muscle fibres respectively. 4. The rate of relaxation following a sudden decrease in [Ca2+] was much lower in the slow-twitch than in the fast-twitch muscle at 5 degrees C, suggesting that properties of the contractile apparatus could play an essential role in determining the rate of relaxation in vivo. 5. There was substantial variation in Ca2+ sensitivity between muscle fibres of the same type from different animals at each temperature. However the steepness of the force-[Ca2+] relation was essentially the same for all fibres of the same type. 6. A change in temperature from 5 to 25 degrees C had a statistically significant effect on the sensitivity of the fast-twitch muscle fibres, rendering them less sensitive to Ca2+ by a factor of 2. However a further increase in temperature from 25 to 35 degrees C did not have any statistically significant effect on the force-[Ca2+] relation in fast-twitch muscle fibres. 7. The effect of temperature on the Ca2+ sensitivity of slow-twitch muscle fibres was not statistically significant

  11. Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity.

    PubMed

    Deng, Xiaojian; Zheng, Nan; Song, Ziyuan; Yin, Lichen; Cheng, Jianjun

    2014-06-01

    Poly(β-amino ester)s (PBAEs) represent an important class of cationic gene delivery materials which, however, suffer from uncontrolled DNA release due in part to the slow degradation of their polyester backbone. Additionally, PBAEs with high molecular weight (MW) also show considerable toxicities. In this study, we designed and developed PBAEs with trigger-responsive domains built-in polymer backbones that can be rapidly cleaved upon external UV light triggering to promote intracellular DNA release as well as reduce material toxicity. Photo-responsive PBAEs were prepared via polyaddition of (2-nitro-1,3-phenylene)bis(methylene) diacrylate and a bifunctional amine. The nitrobenzene moiety was placed in each repeating unit of the PBAE to allow fast response to external UV irradiation, and thus the ester linkers were cleaved and the polymers were degraded within several minutes upon UV irradiation. Cationic PBAEs with high MWs were able to mediate effective intracellular gene delivery, while upon UV irradiation post-transfection, enhanced DNA unpackaging and reduced material toxicity were observed, which collectively contributed to greatly improved transfection efficiencies in various mammalian cell types tested. This strategy allows precise manipulation of material toxicity and gene release profiles of PBAEs, and thus provides an effective design approach to address critical issues in non-viral gene delivery. PMID:24674461

  12. A Flexible Latent Trait Model for Response Times in Tests

    ERIC Educational Resources Information Center

    Ranger, Jochen; Kuhn, Jorg-Tobias

    2012-01-01

    Latent trait models for response times in tests have become popular recently. One challenge for response time modeling is the fact that the distribution of response times can differ considerably even in similar tests. In order to reduce the need for tailor-made models, a model is proposed that unifies two popular approaches to response time…

  13. Fast Response, vertically oriented graphene nanosheet electric double layer capacitors synthesized from C(2)H(2).

    PubMed

    Cai, Minzhen; Outlaw, Ronald A; Quinlan, Ronald A; Premathilake, Dilshan; Butler, Sue M; Miller, John R

    2014-06-24

    The growth and electrical characteristics of vertically oriented graphene nanosheets grown by radio frequency plasma-enhanced chemical vapor deposition from C2H2 feedstock on nickel substrates and used as electrodes in symmetric electric double layer capacitors (EDLC) are presented. The nanosheets exhibited 2.7 times faster growth rate and much greater specific capacitance for a given growth time than CH4 synthesized films. Raman spectra showed that the intensity ratio of the D band to G band versus temperature initially decreased to a minimum value of 0.45 at a growth temperature of 750 °C, but increased rapidly with further temperature increase (1.15 at 850 °C). The AC specific capacitance at 120 Hz of these EDLC devices increased in a linear fashion with growth temperature, up to 265 μF/cm(2) (2 μm high film, 850 °C with 10 min growth). These devices exhibited ultrafast frequency response: the frequency response at -45° phase angle reached over 20 kHz. Consistent with the increase in D band to G band ratio, the morphology of the films became less vertical, less crystalline, and disordered at substrate temperatures of 800 °C and above. This deterioration in morphology resulted in an increase in graphene surface area and defect density, which, in turn, contributed to the increased capacitance, as well as a slight decrease in frequency response. The low equivalent series resistance varied from 0.07 to 0.08 Ω and was attributed to the significant carbon incorporation into the Ni substrate. PMID:24797018

  14. Fast responses of metabolites in Vicia faba L. to moderate NaCl stress.

    PubMed

    Geilfus, Christoph-Martin; Niehaus, Karsten; Gödde, Victoria; Hasler, Mario; Zörb, Christian; Gorzolka, Karin; Jezek, Mareike; Senbayram, Mehmet; Ludwig-Müller, Jutta; Mühling, Karl H

    2015-07-01

    Salt stress impairs global agricultural crop production by reducing vegetative growth and yield. Despite this importance, a number of gaps exist in our knowledge about very early metabolic responses that ensue minutes after plants experience salt stress. Surprisingly, this early phase remains almost as a black box. Therefore, systematic studies focussing on very early plant physiological responses to salt stress (in this case NaCl) may enhance our understanding on strategies to develop crop plants with a better performance under saline conditions. In the present study, hydroponically grown Vicia faba L. plants were exposed to 90 min of NaCl stress, whereby every 15 min samples were taken for analyzing short-term physiologic responses. Gas chromatography-mass spectrometry-based metabolite profiles were analysed by calculating a principal component analysis followed by multiple contrast tests. Follow-up experiments were run to analyze downstream effects of the metabolic changes on the physiological level. The novelty of this study is the demonstration of complex stress-induced metabolic changes at the very beginning of a moderate salt stress in V. faba, information that are very scant for this early stage. This study reports for the first that the proline analogue trans-4-hydroxy-L-proline, known to inhibit cell elongation, was increasingly synthesized after NaCl-stress initiation. Leaf metabolites associated with the generation or scavenging of reactive oxygen species (ROS) were affected in leaves that showed a synchronized increase in ROS formation. A reduced glutamine synthetase activity indicated that disturbances in the nitrogen assimilation occur earlier than it was previously thought under salt stress.

  15. Fast Response, vertically oriented graphene nanosheet electric double layer capacitors synthesized from C(2)H(2).

    PubMed

    Cai, Minzhen; Outlaw, Ronald A; Quinlan, Ronald A; Premathilake, Dilshan; Butler, Sue M; Miller, John R

    2014-06-24

    The growth and electrical characteristics of vertically oriented graphene nanosheets grown by radio frequency plasma-enhanced chemical vapor deposition from C2H2 feedstock on nickel substrates and used as electrodes in symmetric electric double layer capacitors (EDLC) are presented. The nanosheets exhibited 2.7 times faster growth rate and much greater specific capacitance for a given growth time than CH4 synthesized films. Raman spectra showed that the intensity ratio of the D band to G band versus temperature initially decreased to a minimum value of 0.45 at a growth temperature of 750 °C, but increased rapidly with further temperature increase (1.15 at 850 °C). The AC specific capacitance at 120 Hz of these EDLC devices increased in a linear fashion with growth temperature, up to 265 μF/cm(2) (2 μm high film, 850 °C with 10 min growth). These devices exhibited ultrafast frequency response: the frequency response at -45° phase angle reached over 20 kHz. Consistent with the increase in D band to G band ratio, the morphology of the films became less vertical, less crystalline, and disordered at substrate temperatures of 800 °C and above. This deterioration in morphology resulted in an increase in graphene surface area and defect density, which, in turn, contributed to the increased capacitance, as well as a slight decrease in frequency response. The low equivalent series resistance varied from 0.07 to 0.08 Ω and was attributed to the significant carbon incorporation into the Ni substrate.

  16. Fast Response Shape Memory Effect Titanium Nickel (TiNi) Foam Torque Tubes

    NASA Technical Reports Server (NTRS)

    Jardine, Peter

    2014-01-01

    Shape Change Technologies has developed a process to manufacture net-shaped TiNi foam torque tubes that demonstrate the shape memory effect. The torque tubes dramatically reduce response time by a factor of 10. This Phase II project matured the actuator technology by rigorously characterizing the process to optimize the quality of the TiNi and developing a set of metrics to provide ISO 9002 quality assurance. A laboratory virtual instrument engineering workbench (LabVIEW'TM')-based, real-time control of the torsional actuators was developed. These actuators were developed with The Boeing Company for aerospace applications.

  17. Meth math: modeling temperature responses to methamphetamine.

    PubMed

    Molkov, Yaroslav I; Zaretskaia, Maria V; Zaretsky, Dmitry V

    2014-04-15

    Methamphetamine (Meth) can evoke extreme hyperthermia, which correlates with neurotoxicity and death in laboratory animals and humans. The objective of this study was to uncover the mechanisms of a complex dose dependence of temperature responses to Meth by mathematical modeling of the neuronal circuitry. On the basis of previous studies, we composed an artificial neural network with the core comprising three sequentially connected nodes: excitatory, medullary, and sympathetic preganglionic neuronal (SPN). Meth directly stimulated the excitatory node, an inhibitory drive targeted the medullary node, and, in high doses, an additional excitatory drive affected the SPN node. All model parameters (weights of connections, sensitivities, and time constants) were subject to fitting experimental time series of temperature responses to 1, 3, 5, and 10 mg/kg Meth. Modeling suggested that the temperature response to the lowest dose of Meth, which caused an immediate and short hyperthermia, involves neuronal excitation at a supramedullary level. The delay in response after the intermediate doses of Meth is a result of neuronal inhibition at the medullary level. Finally, the rapid and robust increase in body temperature induced by the highest dose of Meth involves activation of high-dose excitatory drive. The impairment in the inhibitory mechanism can provoke a life-threatening temperature rise and makes it a plausible cause of fatal hyperthermia in Meth users. We expect that studying putative neuronal sites of Meth action and the neuromediators involved in a detailed model of this system may lead to more effective strategies for prevention and treatment of hyperthermia induced by amphetamine-like stimulants.

  18. Fast response and high sensitivity to microsaccades in a cascading-adaptation neural network with short-term synaptic depression

    NASA Astrophysics Data System (ADS)

    Yuan, Wu-Jie; Zhou, Jian-Fang; Zhou, Changsong

    2016-04-01

    Microsaccades are very small eye movements during fixation. Experimentally, they have been found to play an important role in visual information processing. However, neural responses induced by microsaccades are not yet well understood and are rarely studied theoretically. Here we propose a network model with a cascading adaptation including both retinal adaptation and short-term depression (STD) at thalamocortical synapses. In the neural network model, we compare the microsaccade-induced neural responses in the presence of STD and those without STD. It is found that the cascading with STD can give rise to faster and sharper responses to microsaccades. Moreover, STD can enhance response effectiveness and sensitivity to microsaccadic spatiotemporal changes, suggesting improved detection of small eye movements (or moving visual objects). We also explore the mechanism of the response properties in the model. Our studies strongly indicate that STD plays an important role in neural responses to microsaccades. Our model considers simultaneously retinal adaptation and STD at thalamocortical synapses in the study of microsaccade-induced neural activity, and may be useful for further investigation of the functional roles of microsaccades in visual information processing.

  19. Fast response and high sensitivity to microsaccades in a cascading-adaptation neural network with short-term synaptic depression.

    PubMed

    Yuan, Wu-Jie; Zhou, Jian-Fang; Zhou, Changsong

    2016-04-01

    Microsaccades are very small eye movements during fixation. Experimentally, they have been found to play an important role in visual information processing. However, neural responses induced by microsaccades are not yet well understood and are rarely studied theoretically. Here we propose a network model with a cascading adaptation including both retinal adaptation and short-term depression (STD) at thalamocortical synapses. In the neural network model, we compare the microsaccade-induced neural responses in the presence of STD and those without STD. It is found that the cascading with STD can give rise to faster and sharper responses to microsaccades. Moreover, STD can enhance response effectiveness and sensitivity to microsaccadic spatiotemporal changes, suggesting improved detection of small eye movements (or moving visual objects). We also explore the mechanism of the response properties in the model. Our studies strongly indicate that STD plays an important role in neural responses to microsaccades. Our model considers simultaneously retinal adaptation and STD at thalamocortical synapses in the study of microsaccade-induced neural activity, and may be useful for further investigation of the functional roles of microsaccades in visual information processing. PMID:27176307

  20. Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice.

    PubMed

    Cordoba-Chacón, José; Gahete, Manuel D; Pozo-Salas, Ana I; de Lecea, Luis; Castaño, Justo P; Luque, Raúl M

    2016-07-01

    Cortistatin (CORT) shares high structural and functional similarities with somatostatin (SST) but displays unique sex-dependent pituitary actions. Indeed, although female CORT-knockout (CORT-KO) mice exhibit enhanced GH expression/secretion, Proopiomelanocortin expression, and circulating ACTH/corticosterone/ghrelin levels, male CORT-KO mice only display increased plasma GH/corticosterone levels. Changes in peripheral ghrelin and SST (rather than hypothalamic levels) seem to regulate GH/ACTH axes in CORT-KOs under fed conditions. Because changes in GH/ACTH axes during fasting provide important adaptive mechanisms, we sought to determine whether CORT absence influences GH/ACTH axes during fasting. Accordingly, fed and fasted male/female CORT-KO were compared with littermate controls. Fasting increased circulating GH levels in male/female controls but not in CORT-KO, suggesting that CORT can be a relevant regulator of GH secretion during fasting. However, GH levels were already higher in CORT-KO than in controls in fed state, which might preclude a further elevation in GH levels. Interestingly, although fasting-induced pituitary GH expression was elevated in both male/female controls, GH expression only increased in fasted female CORT-KOs, likely owing to specific changes observed in key factors controlling somatotrope responsiveness (ie, circulating ghrelin and IGF-1, and pituitary GHRH and ghrelin receptor expression). Fasting increased corticosterone levels in control and, most prominently, in CORT-KO mice, which might be associated with a desensitization to SST signaling and to an augmentation in CRH and ghrelin-signaling regulating corticotrope function. Altogether, these results provide compelling evidence that CORT plays a key, sex-dependent role in the regulation of the GH/ACTH axes in response to fasting. PMID:27175972

  1. Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal change.

    PubMed

    Guderley, Helga; St-Pierre, Julie

    2002-08-01

    Temperature is one of the most important environmental factors affecting the physiology of animals. Seasonal fluctuations in temperature are of particular importance in aquatic ectotherms since their body temperature is in equilibrium with their environment. When an organism faces adverse environmental conditions, it can either remain active or enter into metabolic depression, adopting the strategy that maximises its fitness. Physiological responses to environmental stress occur at many different levels of organisation in an animal. Here, we focus on mitochondria, given their central importance in cellular energy metabolism. We contrast the thermal biology of skeletal muscle mitochondria from cold-active species with that of species that spend their winters in a metabolically depressed state. Specifically, we examine the modifications of mitochondrial properties during thermal/seasonal acclimation and examine mechanisms by which these modifications can arise. While compensatory responses to cold acclimation include increases in mitochondrial abundance, in the oxidative capacities of individual mitochondria and adjustments of ADP affinities, metabolic depression can reduce tissue levels of mitochondrial enzymes and mitochondrial proton leak rates. PMID:12110658

  2. Fast electromagnetic modeling in cylindrically layered media excited by eccentred magnetic dipole

    NASA Astrophysics Data System (ADS)

    Nikitenko, Marina; Itskovich, Gregory B.; Seryakov, Alexander

    2016-06-01

    We developed a fast algorithm to calculate a response of cylindrically layered media excited by the vertical magnetic dipole eccentred with respect to the axis of symmetry. The algorithm calculates response in the range of frequencies typical for induction and dielectric logging. The media conductivity and dielectric constant are described by piecewise-constant functions. The corresponding boundary value problem is solved by method of separation of variables. Fourier transform is applied to Maxwell equations and boundary conditions to express field components through Fourier transforms of vertical components of an electrical and magnetic field. In addition, an expansion of vertical components into an infinite series with respect to angular harmonics is used to reduce the original problem to a series of 1-D problems that only depend on the radial coordinate. The solution to each 1-D radial problem for the angular harmonics is presented as a linear combination of modified Bessel functions. Finally, inverse Fourier transformation is applied to the angular harmonics of vertical components to derive electrical and magnetic field of the original boundary value problem. We provide detailed discussion on the elements that are critical for the numerical implementation of the algorithm: a proper normalization, convergence, and integration. Specifically, we show how to perform integration in the complex plane by avoiding intersection of the integration pass with the cuts located on the Riemann surface. Numerical results show the usefulness of the algorithm for solving inverse problems and for studying the effect of eccentricity in induction and dielectric logging.

  3. Fast and stable explicit operator splitting methods for phase-field models

    NASA Astrophysics Data System (ADS)

    Cheng, Yuanzhen; Kurganov, Alexander; Qu, Zhuolin; Tang, Tao

    2015-12-01

    Numerical simulations of phase-field models require long time computations and therefore it is necessary to develop efficient and highly accurate numerical methods. In this paper, we propose fast and stable explicit operator splitting methods for both one- and two-dimensional nonlinear diffusion equations for thin film epitaxy with slope selection and the Cahn-Hilliard equation. The equations are split into nonlinear and linear parts. The nonlinear part is solved using a method of lines together with an efficient large stability domain explicit ODE solver. The linear part is solved by a pseudo-spectral method, which is based on the exact solution and thus has no stability restriction on the time-step size. We demonstrate the performance of the proposed methods on a number of one- and two-dimensional numerical examples, where different stages of coarsening such as the initial preparation, alternating rapid structural transition and slow motion can be clearly observed.

  4. Evaluation of Fast-Time Wake Models Using Denver 2006 Field Experiment Data

    NASA Technical Reports Server (NTRS)

    Ahmad, Nash’at N.; Pruis, Matthew J.

    2015-01-01

    The National Aeronautics and Space Administration conducted a series of wake vortex field experiments at Denver in 2003, 2005, and 2006. This paper describes the lidar wake vortex measurements and associated meteorological data collected during the 2006 deployment, and includes results of recent reprocessing of the lidar data using a new wake vortex algorithm and estimates of the atmospheric turbulence using a new algorithm to estimate eddy dissipation rate from the lidar data. The configuration and set-up of the 2006 field experiment allowed out-of-ground effect vortices to be tracked in lateral transport further than any previous campaign and thereby provides an opportunity to study long-lived wake vortices in moderate to low crosswinds. An evaluation of NASA's fast-time wake vortex transport and decay models using the dataset shows similar performance as previous studies using other field data.

  5. Fast asthenosphere motion in high-resolution global mantle flow models

    NASA Astrophysics Data System (ADS)

    Weismüller, Jens; Gmeiner, Björn; Ghelichkhan, Siavash; Huber, Markus; John, Lorenz; Wohlmuth, Barbara; Rüde, Ulrich; Bunge, Hans-Peter

    2015-09-01

    A variety of geologic observations point to fast upper mantle flow that may exceed plate tectonic velocities by an order of magnitude. At the same time there is mounting evidence from seismology for flow-like structures in the upper 100-200 km of the mantle. Here we present a set of geodynamic simulations to link these observations. In a synthetic setting, we include asthenospheric channels of varying thickness, with an extreme case of 100 km, and a significant viscosity contrast of up to 4 orders of magnitude relative to the deeper mantle. Using our new global high-resolution code TERRA-NEO, we obtain an increase in velocity by a factor of 10 between a 1000 km thick and the very thin channel, translating into velocities of ˜ 20 cm/a within the narrow asthenosphere. We further present and verify a simple Poiseuille flow model, predicting that the upper mantle velocity scales with the inverse of the asthenosphere thickness.

  6. A fast radiative transfer model for SSMIS upper atmosphere sounding channels

    NASA Astrophysics Data System (ADS)

    Han, Yong; Weng, Fuzhong; Liu, Quanhua; van Delst, Paul

    2007-06-01

    Special Sensor Microwave Imager/Sounder (SSMIS) on board the Defense Meteorology Satellite Program (DMSP) F-16 satellite probes the atmospheric temperature from surface to 100 km. SSMIS channels 19-22 are significantly affected by Zeeman splitting, which is dependent on the Earth's magnetic field. Thus, in satellite data assimilation or retrieval systems, SSMIS brightness temperatures and their Jacobians (or gradient with respect to temperature) must be computed with a fast radiative transfer (RT) scheme that takes into account the Zeeman-splitting effect. In this study, an averaged transmittance within the channel frequency passbands is parameterized and predicted with atmospheric temperature, geomagnetic field strength, and the angle between the geomagnetic field vector and the electromagnetic wave propagation direction. The coefficients of predictors are trained with a line-by-line (LBL) radiative transfer model that accurately computes the monochromatic transmittances at fine frequency steps within each passband. The new radiative transfer scheme is compared to the results from the line-by-line model for the dependent and independent data sets. It is shown that the differences between the two models are well below the instrument noise levels but the new scheme is much faster. It is also shown that the SSMIS measurements agree well with the simulations that are based on the atmospheric profiles from the sounding of the atmosphere using broadband emission radiometry (SABER) on the Thermosphere-lonosphere-Mesosphere Energetics and Dynamics satellite and the COSPAR international reference atmosphere (CIRA) model.

  7. Modeling and design of a normal stress electromagnetic actuator with linear characteristics for fast steering mirror

    NASA Astrophysics Data System (ADS)

    Long, Yongjun; Wei, Xiaohui; Wang, Chunlei; Dai, Xin; Wang, Shigang

    2014-05-01

    A new rotary normal stress electromagnetic actuator for fast steering mirror (FSM) is presented. The study includes concept design, actuating torque modeling, actuator design, and validation with numerical simulation. To achieve an FSM with compact structure and high bandwidth, the actuator is designed with a cross armature magnetic topology. By introducing bias flux generated by four permanent magnets (PMs), the actuator has high-force density similar to a solenoid but also has essentially linear characteristics similar to a voice coil actuator, leading to a simply control algorithm. The actuating torque output is a linear function of both driving current and rotation angle and is formulated with equivalent magnetic circuit method. To improve modeling accuracy, both the PM flux and coil flux leakages are taken into consideration through finite element simulation. Based on the established actuator model, optimal design of the actuator is presented to meet the requirement of our FSM. Numerical simulation is then presented to validate the concept design, established actuator model, and designed actuator. It is shown that the calculated results are in a good agreement with the simulation results.

  8. Physics model of a gas-cooled fast reactor: Review and assessment

    SciTech Connect

    Choi, H.

    2012-07-01

    The current physics design and analysis model was reviewed and assessed for its application to a long-life gas-cooled fast reactor (GFR) design. The physics design uses MICROX, BURP, and DIF3D for the cross section generation, depletion calculation, and criticality and flux calculation, respectively. For the application to the long-life GFR, the depletion model was adjusted such that more lumped fission products are included in the burn-up chain to preserve the reaction rate and fuel mass. The performance of the physics design tools including the adjustment of the depletion model was assessed against Monte Carlo depletion calculations. The comparison has shown that the excess reactivity and cycle length of the long-life GFR are reasonably predicted. Some discrepancies were found at the beginning of cycle, which can be attributed to the differences between the nuclear data used in each model. Further studies will be carried out to update the cross section library of the MICROX code for agreement with the latest sets and to expand the fuel burn-up chain for the high burn-up and recycling fuel cycle analysis. (authors)

  9. General relativistic considerations of the field shedding model of fast radio bursts

    NASA Astrophysics Data System (ADS)

    Punsly, Brian; Bini, Donato

    2016-06-01

    Popular models of fast radio bursts (FRBs) involve the gravitational collapse of neutron star progenitors to black holes. It has been proposed that the shedding of the strong neutron star magnetic field (B) during the collapse is the power source for the radio emission. Previously, these models have utilized the simplicity of the Schwarzschild metric which has the restriction that the magnetic flux is magnetic `hair' that must be shed before final collapse. But neutron stars have angular momentum and charge and a fully relativistic Kerr-Newman solution exists in which B has its source inside of the event horizon. In this Letter, we consider the magnetic flux to be shed as a consequence of the electric discharge of a metastable collapsed state of a Kerr-Newman black hole. It has also been argued that the shedding model will not operate due to pair creation. By considering the pulsar death line, we find that for a neutron star with B = 1011-1013 G and a long rotation period, >1s this is not a concern. We also discuss the observational evidence supporting the plausibility of magnetic flux shedding models of FRBs that are spawned from rapidly rotating progenitors.

  10. Fast 3D modeling in complex environments using a single Kinect sensor

    NASA Astrophysics Data System (ADS)

    Yue, Haosong; Chen, Weihai; Wu, Xingming; Liu, Jingmeng

    2014-02-01

    Three-dimensional (3D) modeling technology has been widely used in inverse engineering, urban planning, robot navigation, and many other applications. How to build a dense model of the environment with limited processing resources is still a challenging topic. A fast 3D modeling algorithm that only uses a single Kinect sensor is proposed in this paper. For every color image captured by Kinect, corner feature extraction is carried out first. Then a spiral search strategy is utilized to select the region of interest (ROI) that contains enough feature corners. Next, the iterative closest point (ICP) method is applied to the points in the ROI to align consecutive data frames. Finally, the analysis of which areas can be walked through by human beings is presented. Comparative experiments with the well-known KinectFusion algorithm have been done and the results demonstrate that the accuracy of the proposed algorithm is the same as KinectFusion but the computing speed is nearly twice of KinectFusion. 3D modeling of two scenes of a public garden and traversable areas analysis in these regions further verified the feasibility of our algorithm.

  11. Internal model control of a fast steering mirror for electro-optical fine tracking

    NASA Astrophysics Data System (ADS)

    Xia, Yun-xia; Bao, Qi-liang; Wu, Qiong-yan

    2010-11-01

    The objective of this research is to develop advanced control methods to improve the bandwidth and tracking precision of the electro-optical fine tracking system using a fast steering mirror (FSM). FSM is the most important part in this control system. The model of FSM is established at the beginning of this paper. Compared with the electro-optical fine tracking system with ground based platform, the electro-optical fine tracking system with movement based platform must be a wide bandwidth and a robustness system. An advanced control method based on internal model control law is developed for electro-optical fine tracking system. The IMC is an advanced algorithm. Theoretically, it can eliminate disturbance completely and make sure output equals to input even there is model error. Moreover, it separates process to the system dynamic characteristic and the object perturbation. Compared with the PID controller, the controller is simpler and the parameter regulation is more convenient and the system is more robust. In addition, we design an improved structure based on classic IMC. The tracking error of the two-port control system is much better than which of the classic IMC. The simulation results indicate that the electro-optical control system based on the internal model control algorithm is very effective. It shows a better performance at the tracing precision and the disturbance suppresses. Thus a new method is provided for the high-performance electro-optical fine tracking system.

  12. Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling

    PubMed Central

    Stanley, Elise F

    2015-01-01

    At fast-transmitting presynaptic terminals Ca2+ enter through voltage gated calcium channels (CaVs) and bind to a synaptic vesicle (SV) -associated calcium sensor (SV-sensor) to gate fusion and discharge. An open CaV generates a high-concentration plume, or nanodomain of Ca2+ that dissipates precipitously with distance from the pore. At most fast synapses, such as the frog neuromuscular junction (NMJ), the SV sensors are located sufficiently close to individual CaVs to be gated by single nanodomains. However, at others, such as the mature rodent calyx of Held (calyx of Held), the physiology is more complex with evidence that CaVs that are both close and distant from the SV sensor and it is argued that release is gated primarily by the overlapping Ca2+ nanodomains from many CaVs. We devised a 'graphic modeling' method to sum Ca2+ from individual CaVs located at varying distances from the SV-sensor to determine the SV release probability and also the fraction of that probability that can be attributed to single domain gating. This method was applied first to simplified, low and high CaV density model release sites and then to published data on the contrasting frog NMJ and the rodent calyx of Held native synapses. We report 3 main predictions: the SV-sensor is positioned very close to the point at which the SV fuses with the membrane; single domain-release gating predominates even at synapses where the SV abuts a large cluster of CaVs, and even relatively remote CaVs can contribute significantly to single domain-based gating. PMID:26457441

  13. Fast and delayed locomotor response to acute high-dose nicotine administration in adult male rats.

    PubMed

    Jandová, K; Marešová, D; Pokorný, J

    2013-01-01

    The aim of the present study was to compare the immediate and delayed locomotor response to high-dose nicotine (NIC) administration in rats. The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour after drug application. Animals were then returned to their cages and housed for another seven days. After this period all animals were placed in Laboras again and their behavioral pattern was retested for another period of one hour (delayed response). Horizontal activity: immediately after nicotine administration animal were less mobile (first 2-minutes interval), when compared with controls. The immobilization effect of nicotine disappeared within 4 minutes and during whole first 10-minutes interval time spent by locomotion did not differ from controls. Locomotion activity of animals treated with nicotine increased robustly in following 10 minutes and remained significantly higher in 2nd, 3rd and 5th 10-minutes interval. Vertical activity: Rearing frequency was significantly lowered by NIC administration in first two minutes of the experiment and the same was found when the duration of rearing was analyzed. Lower rearing intensity of NIC treated animals disappeared in 4 minutes and was finally higher during whole test session as compared with controls. When duration of rearing was analyzed it was significantly longer in NIC treated animals. In majority of observed behavioral aspects there were no differences between NIC treated rats and controls seven days after NIC or SAL treatment. Our results reflect effect of NIC and we conclude that NIC significantly influences behavior of experimental animals.

  14. A Fast and Efficient Version of the TwO-Moment Aerosol Sectional (TOMAS) Global Aerosol Microphysics Model

    NASA Technical Reports Server (NTRS)

    Lee, Yunha; Adams, P. J.

    2012-01-01

    This study develops more computationally efficient versions of the TwO-Moment Aerosol Sectional (TOMAS) microphysics algorithms, collectively called Fast TOMAS. Several methods for speeding up the algorithm were attempted, but only reducing the number of size sections was adopted. Fast TOMAS models, coupled to the GISS GCM II-prime, require a new coagulation algorithm with less restrictive size resolution assumptions but only minor changes in other processes. Fast TOMAS models have been evaluated in a box model against analytical solutions of coagulation and condensation and in a 3-D model against the original TOMAS (TOMAS-30) model. Condensation and coagulation in the Fast TOMAS models agree well with the analytical solution but show slightly more bias than the TOMAS-30 box model. In the 3-D model, errors resulting from decreased size resolution in each process (i.e., emissions, cloud processing wet deposition, microphysics) are quantified in a series of model sensitivity simulations. Errors resulting from lower size resolution in condensation and coagulation, defined as the microphysics error, affect number and mass concentrations by only a few percent. The microphysics error in CN70CN100 (number concentrations of particles larger than 70100 nm diameter), proxies for cloud condensation nuclei, range from 5 to 5 in most regions. The largest errors are associated with decreasing the size resolution in the cloud processing wet deposition calculations, defined as cloud-processing error, and range from 20 to 15 in most regions for CN70CN100 concentrations. Overall, the Fast TOMAS models increase the computational speed by 2 to 3 times with only small numerical errors stemming from condensation and coagulation calculations when compared to TOMAS-30. The faster versions of the TOMAS model allow for the longer, multi-year simulations required to assess aerosol effects on cloud lifetime and precipitation.

  15. Modeling listeners' emotional response to music.

    PubMed

    Eerola, Tuomas

    2012-10-01

    An overview of the computational prediction of emotional responses to music is presented. Communication of emotions by music has received a great deal of attention during the last years and a large number of empirical studies have described the role of individual features (tempo, mode, articulation, timbre) in predicting the emotions suggested or invoked by the music. However, unlike the present work, relatively few studies have attempted to model continua of expressed emotions using a variety of musical features from audio-based representations in a correlation design. The construction of the computational model is divided into four separate phases, with a different focus for evaluation. These phases include the theoretical selection of relevant features, empirical assessment of feature validity, actual feature selection, and overall evaluation of the model. Existing research on music and emotions and extraction of musical features is reviewed in terms of these criteria. Examples drawn from recent studies of emotions within the context of film soundtracks are used to demonstrate each phase in the construction of the model. These models are able to explain the dominant part of the listeners' self-reports of the emotions expressed by music and the models show potential to generalize over different genres within Western music. Possible applications of the computational models of emotions are discussed.

  16. Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1G93A ALS Mouse Model

    PubMed Central

    Ryans, Julie; Russell, Alan J.; Jia, Zhiheng; Hinken, Aaron C.; Morgans, David J.; Malik, Fady I.; Jasper, Jeffrey R.

    2014-01-01

    Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years from the onset of symptoms. Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. Here, we demonstrate that a single dose of tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in tirasemtiv-treated female B6SJL-SOD1G93A mice. These results support the potential of fast skeletal troponin activators to improve muscle function in neuromuscular diseases. PMID:24805850

  17. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.

    PubMed

    Hwee, Darren T; Kennedy, Adam; Ryans, Julie; Russell, Alan J; Jia, Zhiheng; Hinken, Aaron C; Morgans, David J; Malik, Fady I; Jasper, Jeffrey R

    2014-01-01

    Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years from the onset of symptoms. Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. Here, we demonstrate that a single dose of tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1 G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in tirasemtiv-treated female B6SJL-SOD1 G93A mice. These results support the potential of fast skeletal troponin activators to improve muscle function in neuromuscular diseases.

  18. A relative survival model for clustered responses.

    PubMed

    Kuss, Oliver; Blankenburg, Thomas; Haerting, Johannes

    2008-06-01

    Relative Survival is the ratio of the overall survival of a group of patients to the expected survival for a demographically similar group. It is commonly used in disease registries to estimate the effect of a particular disease when the true cause of death is not reliably known. Regression models for relative survival have been described and we extend these models to allow for clustered responses by embedding them into the class of Generalized linear mixed models (GLMM). The method is motivated and demonstrated by a data set from the HALLUCA study, an epidemiological study which investigated provision of medical care to lung cancer patients in the region of Halle in the eastern part of Germany.

  19. Ballistic Response of Fabrics: Model and Experiments

    NASA Astrophysics Data System (ADS)

    Orphal, Dennis L.; Walker Anderson, James D., Jr.

    2001-06-01

    Walker (1999)developed an analytical model for the dynamic response of fabrics to ballistic impact. From this model the force, F, applied to the projectile by the fabric is derived to be F = 8/9 (ET*)h^3/R^2, where E is the Young's modulus of the fabric, T* is the "effective thickness" of the fabric and equal to the ratio of the areal density of the fabric to the fiber density, h is the displacement of the fabric on the axis of impact and R is the radius of the fabric deformation or "bulge". Ballistic tests against Zylon^TM fabric have been performed to measure h and R as a function of time. The results of these experiments are presented and analyzed in the context of the Walker model. Walker (1999), Proceedings of the 18th International Symposium on Ballistics, pp. 1231.

  20. Development of Spectral and Atomic Models for Diagnosing Energetic Particle Characteristics in Fast Ignition Experiments

    SciTech Connect

    MacFarlane, Joseph J

    2009-08-07

    This Final Report summarizes work performed under DOE STTR Phase II Grant No. DE-FG02-05ER86258 during the project period from August 2006 to August 2009. The project, “Development of Spectral and Atomic Models for Diagnosing Energetic Particle Characteristics in Fast Ignition Experiments,” was led by Prism Computational Sciences (Madison, WI), and involved collaboration with subcontractors University of Nevada-Reno and Voss Scientific (Albuquerque, NM). In this project, we have: Developed and implemented a multi-dimensional, multi-frequency radiation transport model in the LSP hybrid fluid-PIC (particle-in-cell) code [1,2]. Updated the LSP code to support the use of accurate equation-of-state (EOS) tables generated by Prism’s PROPACEOS [3] code to compute more accurate temperatures in high energy density physics (HEDP) plasmas. Updated LSP to support the use of Prism’s multi-frequency opacity tables. Generated equation of state and opacity data for LSP simulations for several materials being used in plasma jet experimental studies. Developed and implemented parallel processing techniques for the radiation physics algorithms in LSP. Benchmarked the new radiation transport and radiation physics algorithms in LSP and compared simulation results with analytic solutions and results from numerical radiation-hydrodynamics calculations. Performed simulations using Prism radiation physics codes to address issues related to radiative cooling and ionization dynamics in plasma jet experiments. Performed simulations to study the effects of radiation transport and radiation losses due to electrode contaminants in plasma jet experiments. Updated the LSP code to generate output using NetCDF to provide a better, more flexible interface to SPECT3D [4] in order to post-process LSP output. Updated the SPECT3D code to better support the post-processing of large-scale 2-D and 3-D datasets generated by simulation codes such as LSP. Updated atomic physics modeling to provide for

  1. Faraday cup with nanosecond response and adjustable impedance for fast electron beam characterization

    SciTech Connect

    Hu Jing; Rovey, Joshua L.

    2011-07-15

    A movable Faraday cup design with simple structure and adjustable impedance is described in this work. This Faraday cup has external adjustable shunt resistance for self-biased measurement setup and 50 {Omega} characteristic impedance to match with 50 {Omega} standard BNC coaxial cable and vacuum feedthroughs for nanosecond-level pulse signal measurements. Adjustable shunt resistance allows self-biased measurements to be quickly acquired to determine the electron energy distribution function. The performance of the Faraday cup is validated by tests of response time and amplitude of output signal. When compared with a reference source, the percent difference of the Faraday cup signal fall time is less than 10% for fall times greater than 10 ns. The percent difference of the Faraday cup signal pulse width is below 6.7% for pulse widths greater than 10 ns. A pseudospark-generated electron beam is used to compare the amplitude of the Faraday cup signal with a calibrated F-70 commercial current transformer. The error of the Faraday cup output amplitude is below 10% for the 4-14 kV tested pseudospark voltages. The main benefit of this Faraday cup is demonstrated by adjusting the external shunt resistance and performing the self-biased method for obtaining the electron energy distribution function. Results from a 4 kV pseudospark discharge indicate a ''double-humped'' energy distribution.

  2. Performance of a fast response miniature Adiabatic Demagnetisation Refrigerator using a single crystal tungsten magnetoresistive heat switch

    NASA Astrophysics Data System (ADS)

    Bartlett, J.; Hardy, G.; Hepburn, I. D.

    2015-12-01

    The performance of a fast thermal response miniature Adiabatic Demagnetisation Refrigerator (ADR) is presented. The miniature ADR is comprised of a fast thermal response Chromium Potassium Alum (CPA) salt pill, two superconducting magnets and unconventionally, a single crystal tungsten magnetoresistive (MR) heat switch. The development of this ADR is a result of the ongoing development of a continuously operating millikelvin cryocooler (mKCC), which will use only magnetoresistive heat switches. The design and performance of the MR heat switch developed for the mKCC and used in the miniature ADR is presented in this paper; the heat switch has a measured Residual Resistivity Ratio of 32,000 ± 3000 and an estimated switching ratio (on thermal conductivity divided by the off thermal conductivity) of 15,200 at 3.6 K and 38,800 at 0.2 K when using a 3 T magnetic field. The performance of the miniature ADR operating from a 3.6 K bath is presented, demonstrating that a complete cycle (magnetisation, cooling to the bath and demagnetisation) can be accomplished in 82 s. A magnet current step test, conducted when the ADR is cold and fully demagnetised, has shown the thermal response of the ADR to be sub-second. The measured hold times of the ADR with just parasitic heat load are given, ranging from 3 min at 0.2 K with 13.14 μW of parasitics, to 924 min at 3 K with 4.55 μW of parasitics. The cooling power has been measured for operating temperatures in the range 0.25-3 K by applying an additional heat load to the ADR via a heater, in order to reduce the hold time to 3 min (i.e. approximately double the recycle time); the maximum cooling power of the miniature ADR (in addition to parasitic load) when operating at 250 mK is 20 μW, which increases to 45 μW at 300 mK and continues to increase linearly to nearly 1.1 mW at 3 K. To conclude, the predicted performance of a tandem continuous ADR utilising two of the miniature ADRs is presented.

  3. On modelling the Fast Radio Burst population and event rate predictions

    NASA Astrophysics Data System (ADS)

    Bera, Apurba; Bhattacharyya, Siddhartha; Bharadwaj, Somnath; Bhat, N. D. Ramesh; Chengalur, Jayaram N.

    2016-04-01

    Assuming that Fast Radio Bursts (FRBs) are of extragalactic origin, we have developed a formalism to predict the FRB detection rate and the redshift distribution of the detected events for a telescope with given parameters. We have adopted FRB 110220, for which the emitted pulse energy is estimated to be E0 = 5.4 × 1033 J, as the reference event. The formalism requires us to assume models for (a) pulse broadening due to scattering in the ionized intergalactic medium - we consider two different models for this, (b) the frequency spectrum of the emitted pulse - we consider a power-law model Eν ∝ ν-α with -5 ≤ α ≤ 5, and (c) the comoving number density of the FRB occurrence rate n(E, wi, z) - we ignore the z dependence and assume a fixed intrinsic pulse width wi = 1 ms for all the FRBs. The distribution of the emitted pulse energy E is modelled through (a) a delta function where all the FRBs have the same energy E = E0, and (b) a Schechter luminosity function where the energies have a spread around E0. The models are all normalized using the four FRBs detected by Thornton et al. Our model predictions for the Parkes telescope are all consistent with the inferred redshift distribution of the 14 FRBs detected there to date. We also find that scattering places an upper limit on the redshift of the FRBs detectable by a given telescope; for the Parkes telescope, this is z ˜ 2. Considering the upcoming Ooty Wide Field Array, we predict an FRB detection rate of ˜0.01 to ˜103 d-1.

  4. Modeling of thermo-mechanical and irradiation behavior of mixed oxide fuel for sodium fast reactors

    NASA Astrophysics Data System (ADS)

    Karahan, Aydın; Buongiorno, Jacopo

    2010-01-01

    An engineering code to model the irradiation behavior of UO2-PuO2 mixed oxide fuel pins in sodium-cooled fast reactors was developed. The code was named fuel engineering and structural analysis tool (FEAST-OXIDE). FEAST-OXIDE has several modules working in coupled form with an explicit numerical algorithm. These modules describe: (1) fission gas release and swelling, (2) fuel chemistry and restructuring, (3) temperature distribution, (4) fuel-clad chemical interaction and (5) fuel-clad mechanical analysis. Given the fuel pin geometry, composition and irradiation history, FEAST-OXIDE can analyze fuel and cladding thermo-mechanical behavior at both steady-state and design-basis transient scenarios. The code was written in FORTRAN-90 program language. The mechanical analysis module implements the LIFE algorithm. Fission gas release and swelling behavior is described by the OGRES and NEFIG models. However, the original OGRES model has been extended to include the effects of joint oxide gain (JOG) formation on fission gas release and swelling. A detailed fuel chemistry model has been included to describe the cesium radial migration and JOG formation, oxygen and plutonium radial distribution and the axial migration of cesium. The fuel restructuring model includes the effects of as-fabricated porosity migration, irradiation-induced fuel densification, grain growth, hot pressing and fuel cracking and relocation. Finally, a kinetics model is included to predict the clad wastage formation. FEAST-OXIDE predictions have been compared to the available FFTF, EBR-II and JOYO databases, as well as the LIFE-4 code predictions. The agreement was found to be satisfactory for steady-state and slow-ramp over-power accidents.

  5. Enhanced propagation modeling of directional aviation noise: A hybrid parabolic equation-fast field program method

    NASA Astrophysics Data System (ADS)

    Rosenbaum, Joyce E.

    2011-12-01

    Commercial air traffic is anticipated to increase rapidly in the coming years. The impact of aviation noise on communities surrounding airports is, therefore, a growing concern. Accurate prediction of noise can help to mitigate the impact on communities and foster smoother integration of aerospace engineering advances. The problem of accurate sound level prediction requires careful inclusion of all mechanisms that affect propagation, in addition to correct source characterization. Terrain, ground type, meteorological effects, and source directivity can have a substantial influence on the noise level. Because they are difficult to model, these effects are often included only by rough approximation. This dissertation presents a model designed for sound propagation over uneven terrain, with mixed ground type and realistic meteorological conditions. The model is a hybrid of two numerical techniques: the parabolic equation (PE) and fast field program (FFP) methods, which allow for physics-based inclusion of propagation effects and ensure the low frequency content, a factor in community impact, is predicted accurately. Extension of the hybrid model to a pseudo-three-dimensional representation allows it to produce aviation noise contour maps in the standard form. In order for the model to correctly characterize aviation noise sources, a method of representing arbitrary source directivity patterns was developed for the unique form of the parabolic equation starting field. With this advancement, the model can represent broadband, directional moving sound sources, traveling along user-specified paths. This work was prepared for possible use in the research version of the sound propagation module in the Federal Aviation Administration's new standard predictive tool.

  6. Theoretical models for the regulation of DNA replication in fast-growing bacteria

    NASA Astrophysics Data System (ADS)

    Creutziger, Martin; Schmidt, Mischa; Lenz, Peter

    2012-09-01

    Growing in always changing environments, Escherichia coli cells are challenged by the task to coordinate growth and division. In particular, adaption of their growth program to the surrounding medium has to guarantee that the daughter cells obtain fully replicated chromosomes. Replication is therefore to be initiated at the right time, which is particularly challenging in media that support fast growth. Here, the mother cell initiates replication not only for the daughter but also for the granddaughter cells. This is possible only if replication occurs from several replication forks that all need to be correctly initiated. Despite considerable efforts during the last 40 years, regulation of this process is still unknown. Part of the difficulty arises from the fact that many details of the relevant molecular processes are not known. Here, we develop a novel theoretical strategy for dealing with this general problem: instead of analyzing a single model, we introduce a wide variety of 128 different models that make different assumptions about the unknown processes. By comparing the predictions of these models we are able to identify the key quantities that allow the experimental discrimination of the different models. Analysis of these quantities yields that out of the 128 models 94 are not consistent with available experimental data. From the remaining 34 models we are able to conclude that mass growth and DNA replication need either to be truly coupled, by coupling DNA replication initiation to the event of cell division, or to the amount of accumulated mass. Finally, we make suggestions for experiments to further reduce the number of possible regulation scenarios.

  7. Tidal Response of Preliminary Jupiter Model

    NASA Astrophysics Data System (ADS)

    Wahl, Sean M.; Hubbard, William B.; Militzer, Burkhard

    2016-11-01

    In anticipation of improved observational data for Jupiter’s gravitational field, from the Juno spacecraft, we predict the static tidal response for a variety of Jupiter interior models based on ab initio computer simulations of hydrogen–helium mixtures. We calculate hydrostatic-equilibrium gravity terms, using the non-perturbative concentric Maclaurin Spheroid method that eliminates lengthy expansions used in the theory of figures. Our method captures terms arising from the coupled tidal and rotational perturbations, which we find to be important for a rapidly rotating planet like Jupiter. Our predicted static tidal Love number, {k}2=0.5900, is ∼10% larger than previous estimates. The value is, as expected, highly correlated with the zonal harmonic coefficient J 2, and is thus nearly constant when plausible changes are made to the interior structure while holding J 2 fixed at the observed value. We note that the predicted static k 2 might change, due to Jupiter’s dynamical response to the Galilean moons, and find reasons to argue that the change may be detectable—although we do not present here a theory of dynamical tides for highly oblate Jovian planets. An accurate model of Jupiter’s tidal response will be essential for interpreting Juno observations and identifying tidal signals from effects of other interior dynamics of Jupiter’s gravitational field.

  8. Development of fast response bi-luminophore pressure-sensitive paint by means of an inkjet printing technique

    NASA Astrophysics Data System (ADS)

    Egami, Y.; Ueyama, J.; Furukawa, S.; Kameya, T.; Matsuda, Y.; Yamaguchi, H.; Niimi, T.

    2015-06-01

    A novel fast response bi-luminophore pressure-sensitive paint (PSP) by inkjet printing of sensor-dot arrays on an anodized aluminum (AA) substrate has been developed for unsteady flow measurements. A bi-luminophore AA-PSP, which is a combination of PSP and temperature-sensitive paint (TSP), is essential for precise pressure measurements, because the PSP result needs the temperature correction. However, a conventional bi-luminophore AA-PSP prepared by a dipping method does not work well due to the interference between the PSP and TSP luminophores. To overcome this problem, we have developed isolated dot arrays of PSP and TSP formed on an anodized aluminum substrate by an inkjet printing method. In this study, platinum tetrakis (pentafluorophenyl) porphyrin (PtTFPP) and ZnS-AgInS2 (ZAIS) were employed as pressure- and temperature-sensitive dyes, respectively. A suitable solvent was chosen for each dye to form the dots with uniform, high luminescence intensity, and high sensitivity. The developed bi-luminophore AA-PSP could simultaneously measure pressure and temperature and could reduce the temperature effect of the PSP from -0.97%/K (without temperature correction) to -0.01%/K (with temperature correction). It showed a pressure response time of 17.8  ±  0.8 μs at 90% pressure rise to a step change of pressure, which is in the same range as a conventional AA-PSP.

  9. High performance organic-inorganic perovskite-optocoupler based on low-voltage and fast response perovskite compound photodetector

    NASA Astrophysics Data System (ADS)

    Li, Dong; Dong, Guifang; Li, Wenzhe; Wang, Liduo

    2015-01-01

    Organic-inorganic hybrid photodetectors attract considerable attention because they can combine the advantages of both organic and inorganic systems. Here, a perovskite compound with a broad absorption spectrum and high power conversion efficiency is used as a photosensitive layer in an organic/inorganic hybrid heterojunction photodetector with a high and fast response. The high sensitivity exceeding 104 is obtained at bias of 0-4 V. Using a tandem organic light-emitting diode (OLED) as the light source, we fabricated an optocoupler device. The optocoupler achieved a maximum photoresponsivity of 1.0 A W-1 at 341.3 μWcm-2 at an input voltage of 6 V. The device also exhibits rapid response times of τrise ~ 20 μs and τfall ~ 17 μs as well as a high current transfer ratio (CTR) of 28.2%. After applying an amplification circuit, the CTR of the optocoupler increases to 263.3%, which is comparable with that of commercial inorganic optocouplers. The developed hybrid optocoupler thus shows great promise for use in photonics.

  10. Polarization independent Fabry-Pérot filter based on polymer-stabilized blue phase liquid crystals with fast response time.

    PubMed

    Chen, Yan-Han; Wang, Chun-Ta; Yu, Chin-Ping; Lin, Tsung-Hsien

    2011-12-01

    This work demonstrates a polarization-independent electrically tunable Fabry-Pérot (FP) filter that is based on polymer-stabilized blue phase liquid crystals (PSBPLCs). An external vertical electric field can be applied to modulate the effective refractive index of the PSBPLCs along the optical axis. Therefore, the wavelength-tuning property of the FP filter is completely independent of the polarization state of the incident light. The change in the birefringence in PSBPLCs is governed by Kerr effect-induced isotropic-to-anisotropic transition, and so the PSBPLCs based FP filter has a short response time. The measured tunability and free spectral range of the FP filter are 0.092 nm/ V and 16nm in the visible region, and 0.12nm/ V and 97nm in the NIR region, respectively, and the response time is in sub-millisecond range. The fast-responding polarization-independent electrically tunable FP filter has substantial potential for practical applications.

  11. Fast-Response, Sensitivitive and Low-Powered Chemosensors by Fusing Nanostructured Porous Thin Film and IDEs-Microheater Chip

    PubMed Central

    Dai, Zhengfei; Xu, Lei; Duan, Guotao; Li, Tie; Zhang, Hongwen; Li, Yue; Wang, Yi; Wang, Yuelin; Cai, Weiping

    2013-01-01

    The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials, and efficient substrate chip for heating and electrical addressing. However, it is challenging to achieve repeatable microstructures across the films and low power consumption of substrate chip. Here we presented a new sensor structure via the fusion of metal-oxide nanoporous films and micro-electro-mechanical systems (MEMS)-based sensing chip. An interdigital-electrodes (IDEs) and microheater integrated MEMS structure is designed and employed as substrate chip to in-situ fabricate colloidal monolayer template-induced metal-oxide (egg. SnO2) nanoporous sensing films. This fused sensor demonstrates mW-level low power, ultrafast response (~1 s), and parts-per-billion lever detection for ethanol gas. Due to the controllable template strategy and mass-production potential, such micro/nano fused high-performance gas sensors will be next-generation key miniaturized/integrated devices for advanced practical applications. PMID:23591580

  12. Multiscale analysis of slow-fast neuronal learning models with noise

    PubMed Central

    2012-01-01

    This paper deals with the application of temporal averaging methods to recurrent networks of noisy neurons undergoing a slow and unsupervised modification of their connectivity matrix called learning. Three time-scales arise for these models: (i) the fast neuronal dynamics, (ii) the intermediate external input to the system, and (iii) the slow learning mechanisms. Based on this time-scale separation, we apply an extension of the mathematical theory of stochastic averaging with periodic forcing in order to derive a reduced deterministic model for the connectivity dynamics. We focus on a class of models where the activity is linear to understand the specificity of several learning rules (Hebbian, trace or anti-symmetric learning). In a weakly connected regime, we study the equilibrium connectivity which gathers the entire ‘knowledge’ of the network about the inputs. We develop an asymptotic method to approximate this equilibrium. We show that the symmetric part of the connectivity post-learning encodes the correlation structure of the inputs, whereas the anti-symmetric part corresponds to the cross correlation between the inputs and their time derivative. Moreover, the time-scales ratio appears as an important parameter revealing temporal correlations. PMID:23174307

  13. Fast Three-Dimensional Method of Modeling Atomic Oxygen Undercutting of Protected Polymers

    NASA Technical Reports Server (NTRS)

    Snyder, Aaron; Banks, Bruce A.

    2002-01-01

    A method is presented to model atomic oxygen erosion of protected polymers in low Earth orbit (LEO). Undercutting of protected polymers by atomic oxygen occurs in LEO due to the presence of scratch, crack or pin-window defects in the protective coatings. As a means of providing a better understanding of undercutting processes, a fast method of modeling atomic-oxygen undercutting of protected polymers has been developed. Current simulation methods often rely on computationally expensive ray-tracing procedures to track the surface-to-surface movement of individual "atoms." The method introduced in this paper replaces slow individual particle approaches by substituting a model that utilizes both a geometric configuration-factor technique, which governs the diffuse transport of atoms between surfaces, and an efficient telescoping series algorithm, which rapidly integrates the cumulative effects stemming from the numerous atomic oxygen events occurring at the surfaces of an undercut cavity. This new method facilitates the systematic study of three-dimensional undercutting by allowing rapid simulations to be made over a wide range of erosion parameters.

  14. A quantitative kinetic model for the fast and isothermal hydrothermal liquefaction of Nannochloropsis sp.

    PubMed

    Hietala, David C; Faeth, Julia L; Savage, Phillip E

    2016-08-01

    Hydrothermal liquefaction (HTL) is a technology for converting algal biomass into biocrude oil and high-value products. To elucidate the underlying kinetics for this process, we conducted isothermal and non-isothermal reactions over a broad range of holding times (10s-60min), temperatures (100-400°C), and average heating rates (110-350°Cmin(-1)). Biocrude reached high yields (⩾37wt%) within 2min for heat-source set-point temperatures of 350°C or higher. We developed a microalgal HTL kinetic model valid from 10s to 60min, including significantly shorter timescales (10s-10min) than any previous model. The model predicts that up to 46wt% biocrude yields are achievable at 400°C and 1min, reaffirming the utility of short holding times and "fast" HTL. We highlight potential trade-offs between maximizing biocrude quantity and facilitating aqueous phase recovery, which may improve biocrude quality. PMID:27128195

  15. Computational modeling of aerodynamics in the fast forward flight of hummingbirds

    NASA Astrophysics Data System (ADS)

    Song, Jialei; Luo, Haoxiang; Tobalske, Bret; Hedrick, Tyson

    2015-11-01

    Computational models of the hummingbird at flight speed 8.3 m/s is built based on high-speed imaging of the real bird flight in the wind tunnel. The goal is to understand the lift and thrust production of the wings at the high advance ratio (flight speed to the average wingtip speed) around 1. Both the full 3D CFD model based on an immersed-boundary method and the blade-element model based on quasi-steady flow assumption were adopted to analyze the aerodynamics. The result shows that while the weight support is generated during downstroke, little negative weight support is produced during upstroke. On the other hand, thrust is generated during both downstroke and upstroke, which allows the bird to overcome drag induced at fast flight. The lift and thrust characteristics are closely related to the instantaneous wing position and motion. In addition, the flow visualization shows that the leading-edge vortex is stable during most of the wing-beat, which may have contributed to the lift and thrust enhancement. NSF CBET-0954381.

  16. A quantitative kinetic model for the fast and isothermal hydrothermal liquefaction of Nannochloropsis sp.

    PubMed

    Hietala, David C; Faeth, Julia L; Savage, Phillip E

    2016-08-01

    Hydrothermal liquefaction (HTL) is a technology for converting algal biomass into biocrude oil and high-value products. To elucidate the underlying kinetics for this process, we conducted isothermal and non-isothermal reactions over a broad range of holding times (10s-60min), temperatures (100-400°C), and average heating rates (110-350°Cmin(-1)). Biocrude reached high yields (⩾37wt%) within 2min for heat-source set-point temperatures of 350°C or higher. We developed a microalgal HTL kinetic model valid from 10s to 60min, including significantly shorter timescales (10s-10min) than any previous model. The model predicts that up to 46wt% biocrude yields are achievable at 400°C and 1min, reaffirming the utility of short holding times and "fast" HTL. We highlight potential trade-offs between maximizing biocrude quantity and facilitating aqueous phase recovery, which may improve biocrude quality.

  17. Fast community detection based on sector edge aggregation metric model in hyperbolic space

    NASA Astrophysics Data System (ADS)

    Wang, Zuxi; Li, Qingguang; Xiong, Wei; Jin, Fengdong; Wu, Yao

    2016-06-01

    By studying the edge aggregation characteristic of nodes in hyperbolic space, Sector Edge Aggregation Metric (SEAM) model is proposed and theoretically proved in this paper. In hyperbolic disk SEAM model determines the minimum angular range of a sector which possesses the maximal edge aggregation of nodes. The set of nodes within such sector has dense internal links, which corresponds with the characteristic of community structure. Based on SEAM model, we propose a fast community detection algorithm called Greedy Optimization Modularity Algorithm (GOMA) which employs greedy optimization strategy and hyperbolic coordinates. GOMA firstly divides initial communities according to the quantitative results of sector edge aggregation given by SEAM and the nodes' hyperbolic coordinates, then based on greedy optimization strategy, only merges the two angular neighboring communities in hyperbolic disk to optimize the network modularity function, and consequently obtains high-quality community detection. The strategies of initial community partition and merger in hyperbolic space greatly improve the speed of searching the most optimal modularity. Experimental results indicate that GOMA is able to detect out high-quality community structure in synthetic and real networks, and performs better when applied to the large-scale and dense networks with strong clustering.

  18. Numerical modeling for energy transport and isochoric heating in ultra-fast heated high Z target

    NASA Astrophysics Data System (ADS)

    Mishra, Rohini; Sentoku, Yasuhiko; Hakel, Peter; Mancini, Roberto C.

    2010-11-01

    Collisional Particle-in-Cell (PIC) code is an effective tool to study extreme energy density conditions achieved in intense laser-solid interactions. In the continuous process of developing PIC code, we have recently implemented models to incorporate dynamic ionizations, namely Saha and Thomas Fermi, and radiation cooling (due to Bremsstrahlung and line emissions). We have also revised the existing collision model to take into account bounded electrons in dynamically ionizing target (partially ionized target). One-dimensional PIC simulation of a gold target with new collision model shows strong local heating in a micron distance due to shorter stopping range of fast electrons, which reflects the increased collision frequency due to bound electrons. The peak temperature in the heated region drops significantly due to the radiation cooling to a level of a few hundred eV from keV. We also discuss the target Z dependence on radiation loss and two-dimensional effects such as the resistive magnetic fields in the hot electron transport in metal targets.

  19. Hybrid Finite Element-Fast Spectral Domain Multilayer Boundary Integral Modeling of Doubly Periodic Structures

    SciTech Connect

    T.F. Eibert; J.L. Volakis; Y.E. Erdemli

    2002-03-03

    Hybrid finite element (FE)--boundary integral (BI) analysis of infinite periodic arrays is extended to include planar multilayered Green's functions. In this manner, a portion of the volumetric dielectric region can be modeled via the finite element method whereas uniform multilayered regions can be modeled using a multilayered Green's function. As such, thick uniform substrates can be modeled without loss of efficiency and accuracy. The multilayered Green's function is analytically computed in the spectral domain and the resulting BI matrix-vector products are evaluated via the fast spectral domain algorithm (FSDA). As a result, the computational cost of the matrix-vector products is kept at O(N). Furthermore, the number of Floquet modes in the expansion are kept very few by placing the BI surfaces within the computational unit cell. Examples of frequency selective surface (FSS) arrays are analyzed with this method to demonstrate the accuracy and capability of the approach. One example involves complicated multilayered substrates above and below an inhomogeneous filter element and the other is an optical ring-slot array on a substrate several hundred wavelengths in thickness. Comparisons with measurements are included.

  20. A new fast fractal modeling approach for the detection of microcalcifications in mammograms.

    PubMed

    Sankar, Deepa; Thomas, Tessamma

    2010-10-01

    In this paper, a novel fast method for modeling mammograms by deterministic fractal coding approach to detect the presence of microcalcifications, which are early signs of breast cancer, is presented. The modeled mammogram obtained using fractal encoding method is visually similar to the original image containing microcalcifications, and therefore, when it is taken out from the original mammogram, the presence of microcalcifications can be enhanced. The limitation of fractal image modeling is the tremendous time required for encoding. In the present work, instead of searching for a matching domain in the entire domain pool of the image, three methods based on mean and variance, dynamic range of the image blocks, and mass center features are used. This reduced the encoding time by a factor of 3, 89, and 13, respectively, in the three methods with respect to the conventional fractal image coding method with quad tree partitioning. The mammograms obtained from The Mammographic Image Analysis Society database (ground truth available) gave a total detection score of 87.6%, 87.6%, 90.5%, and 87.6%, for the conventional and the proposed three methods, respectively.

  1. Assessing the Importance of Nonlinearities in the Development of a Substructure Model for the Wind Turbine CAE Tool FAST: Preprint

    SciTech Connect

    Damiani, R.; Jonkman, J.; Robertson, A.; Song, H.

    2013-03-01

    Design and analysis of wind turbines are performed using aero-servo-elastic tools that account for the nonlinear coupling between aerodynamics, controls, and structural response. The NREL-developed computer-aided engineering (CAE) tool FAST also resolves the hydrodynamics of fixed-bottom structures and floating platforms for offshore wind applications. This paper outlines the implementation of a structural-dynamics module (SubDyn) for offshore wind turbines with space-frame substructures into the current FAST framework, and focuses on the initial assessment of the importance of structural nonlinearities. Nonlinear effects include: large displacements, axial shortening due to bending, cross-sectional transverse shear effects, etc.

  2. Synthesis of fast response crosslinked PVA-g-NIPAAm nanohydrogels by very low radiation dose in dilute aqueous solution

    NASA Astrophysics Data System (ADS)

    Fathi, Marziyeh; Reza Farajollahi, Ali; Akbar Entezami, Ali

    2013-05-01

    Nanohydrogels of poly(vinyl alcohol)-g-N-isopropylacrylamide (PVA-g-NIPAAm) are synthesized by PVA and NIPAAm dilute aqueous solution using much less radiation dose of 1-20 Gy via intramolecular crosslinking at ambient temperature. The radiation synthesis of nanohydrogels is performed in the presence of tetrakis (hydroxymethyl) phosphonium chloride (THPC) due to its rapid oxygen scavenging abilities and hydrogen peroxide (H2O2) as a source of hydroxyl radicals. The effect of radiation dose, feed composition ratio of PVA and H2O2 is investigated on swelling properties such as temperature and pH dependence of equilibrium swelling ratio as well as deswelling kinetics. Experimental data exhibit high equilibrium swelling ratio and fast response time for the synthesized nanohydrogels. The average molecular weight between crosslinks (Mc) and crosslinking density (ρx) of the obtained nanohydrogels are calculated from swelling data as a function of radiation dose, H2O2 and PVA amount. Fourier transform infrared spectroscopy (FT-IR), elemental analysis of nitrogen content and thermogravimetric analysis (TGA) are used to confirm the grafting reaction. Lower critical solution temperature (LCST) is measured around 33 °C by differential scanning calorimetry (DSC) for PVA-g-NIPAAm nanohydrogels. Dynamic light scattering (DLS) data demonstrate that the increase of radiation dose leads to the decreasing in dimension of nanohydrogels. Also, rheological studies are confirmed an improvement in the mechanical properties of the nanohydrogels with increasing the radiation dose. A cytotoxicity study exhibits a good biocompatibility for the obtained nanohydrogels. The prepared nanohydrogels show fast swelling/deswelling behavior, high swelling ratio, dual sensitivity and good cytocompatibility, which may find potential applications as biomaterial.

  3. Solid polystyrene and deuterated polystyrene light output response to fast neutrons.

    PubMed

    Simpson, R; Danly, C; Glebov, V Yu; Hurlbut, C; Merrill, F E; Volegov, P L; Wilde, C

    2016-04-01

    The Neutron Imaging System has proven to be an important diagnostic in studying DT implosion characteristics at the National Ignition Facility. The current system depends on a polystyrene scintillating fiber array, which detects fusion neutrons born in the DT hotspot as well as neutrons that have scattered to lower energies in the surrounding cold fuel. Increasing neutron yields at NIF, as well as a desire to resolve three-dimensional information about the fuel assembly, have provided the impetus to build and install two additional next-generation neutron imaging systems. We are currently investigating a novel neutron imaging system that will utilize a deuterated polystyrene (CD) fiber array instead of standard hydrogen-based polystyrene (CH). Studies of deuterated xylene or deuterated benzene liquid scintillator show an improvement in imaging resolution by a factor of two [L. Disdier et al., Rev. Sci. Instrum. 75, 2134 (2004)], but also a reduction in light output [V. Bildstein et al., Nucl. Instrum. Methods Phys. Res., Sect. A 729, 188 (2013); M. I. Ojaruega, Ph.D. thesis, University of Michigan, 2009; M. T. Febbraro, Ph.D. thesis, University of Michigan, 2014] as compared to standard plastic. Tests of the relative light output of deuterated polystyrene and standard polystyrene were completed using 14 MeV fusion neutrons generated through implosions of deuterium-tritium filled capsules at the OMEGA laser facility. In addition, we collected data of the relative response of these two scintillators to a wide energy range of neutrons (1-800 MeV) at the Weapons Neutrons Research Facility. Results of these measurements are presented.

  4. Solid polystyrene and deuterated polystyrene light output response to fast neutrons

    NASA Astrophysics Data System (ADS)

    Simpson, R.; Danly, C.; Glebov, V. Yu.; Hurlbut, C.; Merrill, F. E.; Volegov, P. L.; Wilde, C.

    2016-04-01

    The Neutron Imaging System has proven to be an important diagnostic in studying DT implosion characteristics at the National Ignition Facility. The current system depends on a polystyrene scintillating fiber array, which detects fusion neutrons born in the DT hotspot as well as neutrons that have scattered to lower energies in the surrounding cold fuel. Increasing neutron yields at NIF, as well as a desire to resolve three-dimensional information about the fuel assembly, have provided the impetus to build and install two additional next-generation neutron imaging systems. We are currently investigating a novel neutron imaging system that will utilize a deuterated polystyrene (CD) fiber array instead of standard hydrogen-based polystyrene (CH). Studies of deuterated xylene or deuterated benzene liquid scintillator show an improvement in imaging resolution by a factor of two [L. Disdier et al., Rev. Sci. Instrum. 75, 2134 (2004)], but also a reduction in light output [V. Bildstein et al., Nucl. Instrum. Methods Phys. Res., Sect. A 729, 188 (2013); M. I. Ojaruega, Ph.D. thesis, University of Michigan, 2009; M. T. Febbraro, Ph.D. thesis, University of Michigan, 2014] as compared to standard plastic. Tests of the relative light output of deuterated polystyrene and standard polystyrene were completed using 14 MeV fusion neutrons generated through implosions of deuterium-tritium filled capsules at the OMEGA laser facility. In addition, we collected data of the relative response of these two scintillators to a wide energy range of neutrons (1-800 MeV) at the Weapons Neutrons Research Facility. Results of these measurements are presented.

  5. Solid polystyrene and deuterated polystyrene light output response to fast neutrons.

    PubMed

    Simpson, R; Danly, C; Glebov, V Yu; Hurlbut, C; Merrill, F E; Volegov, P L; Wilde, C

    2016-04-01

    The Neutron Imaging System has proven to be an important diagnostic in studying DT implosion characteristics at the National Ignition Facility. The current system depends on a polystyrene scintillating fiber array, which detects fusion neutrons born in the DT hotspot as well as neutrons that have scattered to lower energies in the surrounding cold fuel. Increasing neutron yields at NIF, as well as a desire to resolve three-dimensional information about the fuel assembly, have provided the impetus to build and install two additional next-generation neutron imaging systems. We are currently investigating a novel neutron imaging system that will utilize a deuterated polystyrene (CD) fiber array instead of standard hydrogen-based polystyrene (CH). Studies of deuterated xylene or deuterated benzene liquid scintillator show an improvement in imaging resolution by a factor of two [L. Disdier et al., Rev. Sci. Instrum. 75, 2134 (2004)], but also a reduction in light output [V. Bildstein et al., Nucl. Instrum. Methods Phys. Res., Sect. A 729, 188 (2013); M. I. Ojaruega, Ph.D. thesis, University of Michigan, 2009; M. T. Febbraro, Ph.D. thesis, University of Michigan, 2014] as compared to standard plastic. Tests of the relative light output of deuterated polystyrene and standard polystyrene were completed using 14 MeV fusion neutrons generated through implosions of deuterium-tritium filled capsules at the OMEGA laser facility. In addition, we collected data of the relative response of these two scintillators to a wide energy range of neutrons (1-800 MeV) at the Weapons Neutrons Research Facility. Results of these measurements are presented. PMID:27131680

  6. The Graded Unfolding Model: A Unidimensional Item Response Model for Unfolding Graded Responses.

    ERIC Educational Resources Information Center

    Roberts, James S.; Laughlin, James E.

    Binary or graded disagree-agree responses to attitude items are often collected for the purpose of attitude measurement. Although such data are sometimes analyzed with cumulative measurement models, recent investigations suggest that unfolding models are more appropriate (J. S. Roberts, 1995; W. H. Van Schuur and H. A. L. Kiers, 1994). Advances in…

  7. MODELING VENTILATION SYSTEM RESPONSE TO FIRE

    SciTech Connect

    Coutts, D

    2007-04-17

    Fires in facilities containing nuclear material have the potential to transport radioactive contamination throughout buildings and may lead to widespread downwind dispersal threatening both worker and public safety. Development and implementation of control strategies capable of providing adequate protection from fire requires realistic characterization of ventilation system response which, in turn, depends on an understanding of fire development timing and suppression system response. This paper discusses work in which published HEPA filter data was combined with CFAST fire modeling predictions to evaluate protective control strategies for a hypothetical DOE non-reactor nuclear facility. The purpose of this effort was to evaluate when safety significant active ventilation coupled with safety class passive ventilation might be a viable control strategy.

  8. The professional responsibility model of physician leadership.

    PubMed

    Chervenak, Frank A; McCullough, Laurence B; Brent, Robert L

    2013-02-01

    The challenges physician leaders confront today call to mind Odysseus' challenge to steer his fragile ship successfully between Scylla and Charybdis. The modern Scylla takes the form of ever-increasing pressures to provide more resources for professional liability, compliance, patient satisfaction, central administration, and a host of other demands. The modern Charybdis takes the form of ever-increasing pressures to procure resources when fewer are available and competition is continuously increasing the need for resources, including managed care, hospital administration, payers, employers, patients who are uninsured or underinsured, research funding, and philanthropy. This publication provides physician leaders with guidance for identifying and managing common leadership challenges on the basis of the professional responsibility model of physician leadership. This model is based on Plato's concept of leadership as a life of service and the professional medical ethics of Drs John Gregory and Thomas Percival. Four professional virtues should guide physician leaders: self-effacement, self-sacrifice, compassion, and integrity. These professional virtues direct physician leaders to treat colleagues as ends in themselves, to provide justice-based resource management, to use power constrained by medical professionalism, and to prevent and respond effectively to organizational dysfunction. The professional responsibility model guides physician leaders by proving an explicit "tool kit" to complement managerial skills.

  9. Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS Lost trial

    PubMed Central

    Wang, Tiange; Huang, Tao; Zheng, Yan; Rood, Jennifer; Bray, George A.; Sacks, Frank M.; Qi, Lu

    2016-01-01

    Objective Weight loss intervention through diet modification has been widely used to improve obesity-related hyperglycemia; however, little is known about whether genetic variation modifies the intervention effect. We examined the interaction between weight-loss diets and genetic variation of fasting glucose on changes in glycemic traits in a dietary intervention trial. Research Design and Methods The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial is a randomized, controlled 2-year weight-loss trial. We assessed overall genetic variation of fasting glucose by calculating a genetic risk score (GRS) based on 14 fasting glucose-associated single nucleotide polymorphisms, and examined the progression in fasting glucose and insulin levels, and insulin resistance and insulin sensitivity in 733 adults from this trial. Results The GRS was associated with 6-month changes in fasting glucose (P<0.001), fasting insulin (P=0.042), homeostasis model assessment of insulin resistance (HOMA-IR, P=0.009) and insulin sensitivity (HOMA-S, P=0.043). We observed significant interaction between the GRS and dietary fat on 6-month changes in fasting glucose, HOMA-IR and HOMA-S after multivariable adjustment (P-interaction=0.007, 0.045, and 0.028, respectively). After further adjustment for weight loss, the interaction remained significant on change in fasting glucose (P=0.015). In the high-fat diet group, participants in the highest GRS tertile showed increased fasting glucose, whereas participants in the lowest tertile showed decreased fasting glucose (P-trend<0.001); in contrast, the genetic association was not significant in the low-fat diet group (P-trend=0.087). Conclusions Our data suggest that participants with a higher genetic risk may benefit more by eating a low-fat diet to improve glucose metabolism. PMID:27113490

  10. Intercomparison of fast response commercial gas analysers for nitrous oxide flux measurements under field conditions

    NASA Astrophysics Data System (ADS)

    Rannik, Ü.; Haapanala, S.; Shurpali, N. J.; Mammarella, I.; Lind, S.; Hyvönen, N.; Peltola, O.; Zahniser, M.; Martikainen, P. J.; Vesala, T.

    2014-08-01

    Four gas analysers capable of measuring nitrous oxide (N2O) concentration at a response time necessary for eddy covariance flux measurements were operated from spring till winter 2011 over a field cultivated with reed canary grass (RCG, Phalaris arundinaceae, L.), a perennial bioenergy crop in Eastern Finland. The instruments were TGA100A (Campbell Scientific Inc.), CW-TILDAS-CS (Aerodyne Research Inc.), N2O/CO-23d (Los Gatos Research Inc.) and QC-TILDAS-76-CS (Aerodyne Research Inc.). The period with high emission, lasting for about two weeks after fertilization in late May, was characterised by an up to two orders of magnitude higher emission, whereas during the rest of the campaign the N2O fluxes were small, from 0.1 to 1 nmol m-2 s-1. Two instruments, CW-TILDAS-CS and N2O/CO-23d, determined the N2O exchange with minor systematic difference throughout the campaign, when operated simultaneously. TGA100A produced cumulatively highest N2O estimates (with 29% higher value during the period when all instruments were operational). QC-TILDAS-76-CS obtained 36% lower fluxes than CW-TILDAS-CS during the first period, including the emission episode, whereas the correspondence with other instruments during the rest of the campaign was good. The reason for these episodic higher and lower estimates by the two instruments is not currently known, suggesting further need for detailed evaluation of instrument performance under field conditions with emphasis on stability, calibration and, in particular, simultaneous accurate determination of water vapour concentration due to its large impact on small N2O fluxes through spectroscopic and dilution corrections. The instrument CW-TILDAS-CS was characterised by the lowest noise level (std around 0.12 ppb at 10 Hz sampling rate), as compared to N2O/CO-23d and QC-TILDAS-76-CS (around 0.50 ppb) and TGA100A (around 2 ppb). Both instruments based on Continuous-Wave Quantum Cascade Lasers, CW-TILDAS-CS and N2O/CO-23d, were able to determine

  11. Mechanistic modeling of turkey growth response to genotype and nutrition.

    PubMed

    Rivera-Torres, V; Ferket, P R; Sauvant, D

    2011-10-01

    Along with the fast genetic improvement, nutritional and environmental effects on poultry growth performance have made it necessary to develop growth models that have the flexibility to adapt to different genotypes and growing conditions. A mechanistic simulation model of energy and nutrient utilization in growing turkeys is presented herein. The model consists of simulating the average homeorhetic and homeostatic regulations associated with the utilization of circulating glucose, fatty acid, AA, and acetyl-CoA for protein and lipid retention in carcass, viscera, and feathers in a turkey population. Homeorhesis plays a major role in the control of protein and lipid turnover for the definition of genetic potential and feed intake, whereas homeostasis adjusts growth rate through protein and lipid turnover rates and, therefore, BW gain and feed intake to the growing conditions. Also, homeostasis enables the maintenance of a dynamic balance state during all the growing period through the control of circulating nutrient concentration. The model was developed and calibrated with experimental data that described energy utilization in male and female growing turkeys. Then, the ability of the model to adapt to genotypes and to predict the average response of a turkey population to dietary energy was evaluated. Model calibration showed simulations of energy and nutrient utilization that fitted well with the experimental data because ME was satisfyingly partitioned into heat production and energy retention as protein and lipid, and nutrient intake accurately partitioned BW gain into carcass, viscera, and feathers. The evaluation of the model was also satisfactory because BW gain and feed-to-gain ratio were globally in accordance with the observations in different male and female genotypes, in spite of an overestimation of the feed-to-gain ratio during the first weeks of age. Model evaluation showed that the BW gain and feed intake response of growing turkeys to dietary energy

  12. [Alteration of neural oscillations in hippocampal CA3 area in the fast avoidance response rat before and after electric shock avoidance training].

    PubMed

    Wang, Wei-Wei; Wang, Dan-Dan; Wang, Dan; Guan, Yan; Tang, Ying-Ying; Ye, Zheng; Li, Jing; Li, Min; Zhu, Zai-Man; Pan, Qun-Wan

    2015-10-25

    The purpose of the present study is to explore the relationship of spatial learning ability and specific electrical activities of neural oscillations in the rat. The fast and general avoidance response groups were selected on the basis of the animals' responses to the electric shock in Y type maze, and their local field potentials (LFPs) of hippocampal CA3 area were recorded by wireless telemetry before and after shock avoidance training, respectively. The components of neural oscillations related to spatial identifying and learning ability were analyzed. The results showed that, compared with the general avoidance response group, the fast avoidance response group did not show any differences of LFPs in hippocampal CA3 area before electric shock avoidance trial, but showed significantly increased percentages of 0-10 Hz and 30-40 Hz rhythm in right hippocampal CA3 area after the shock avoidance training (P < 0.01 or P < 0.05). Fast Fourier transform showed that percentage increase of 0-10 Hz band occurred mainly in θ (3-7 Hz) frequency, and 30-40 Hz frequency change was equivalent to the γ1 band. Furthermore, compared with those before training, only the percentages of β, β2 (20-30 Hz) and γ1 rhythm increased (P < 0.01 or P < 0.05) in fast avoidance response rats after training, while the θ rhythm percentage remained unchanged. In contrast, θ rhythm percentage and the large amplitude (intensity: +2.5 - -2.5 db) θ waves in right CA3 area of general avoidance response rats were significantly reduced after training (P < 0.01). These results suggest that the increased percentages of β2 and γ1 rhythm and high-level (unchanged) percentage of θ rhythm in the right hippocampus CA3 area might be related to strong spatial cognition ability of fast avoidance response rats.

  13. Particle Size Distributions During Laboratory-Scale Biomass Burns and Prescribed Burns Using Fast Response Instruments

    NASA Astrophysics Data System (ADS)

    Jung, H.; Hosseini, E.; Li, Q.; Cocker, D.; Weise, D.; Miller, A.; Shrivastava, M.; Miller, W.; Princevac, M.; Mahalingam, S.

    2010-12-01

    Particle size distribution from biomass combustion in an important parameter as it affects air quality, climate modelling and health effects. To date particle size distributions reported from prior studies varies not only due to difference in fuels but also difference in experimental conditions. This study aims to report characteristics of particle size distribution in a well controlled repeatable lab scale biomass fires for southwestern US fuels and compare with that from prescribed burns. The combustion laboratory at the USDA Forest Service’s Fire Science Laboratory (FSL), Missoula, MT provided repeatable combustion and dilution environment ideal for particle size distribution study. For a variety of fuels tested the major mode of particle size distribution was in the range of 29 to 52 nm, which is attributable to dilution of the fresh smoke. Comparing volume size distribution from FMPS and APS measurement ~30 % of particle volume was attributable to the particles ranging from 0.5 to 10 µm for PM10. Geometric mean diameter rapidly increased during flaming and gradually decreased during mixed and smoldering phase combustion. Most of fuels gave unimodal distribution during flaming phase and strong biomodal distribution during smoldering phase. The mode of combustion (flaming, mixed and smoldering) could be better distinguished using slopes in MCE vs geometric mean diameter from each mode of combustion than only using MCE values. Prescribed burns were carried out at wildland managed by military bases. Evolution of particle distribution in and out of the plume will be compared with particle distribution from lab scale burning.

  14. Particle size distributions from laboratory-scale biomass fires using fast response instruments

    NASA Astrophysics Data System (ADS)

    Hosseini, S.; Li, Q.; Cocker, D.; Weise, D.; Miller, A.; Shrivastava, M.; Miller, J. W.; Mahalingam, S.; Princevac, M.; Jung, H.

    2010-08-01

    Particle size distribution from biomass combustion is an important parameter as it affects air quality, climate modelling and health effects. To date, particle size distributions reported from prior studies vary not only due to difference in fuels but also difference in experimental conditions. This study aims to report characteristics of particle size distributions in well controlled repeatable lab scale biomass fires for southwestern United States fuels with focus on chaparral. The combustion laboratory at the United States Department of Agriculture-Forest Service's Fire Science Laboratory (USDA-FSL), Missoula, MT provided a repeatable combustion and dilution environment ideal for measurements. For a variety of fuels tested the major mode of particle size distribution was in the range of 29 to 52 nm, which is attributable to dilution of the fresh smoke. Comparing mass size distribution from FMPS and APS measurement 51-68% of particle mass was attributable to the particles ranging from 0.5 to 10 μm for PM10. Geometric mean diameter rapidly increased during flaming and gradually decreased during mixed and smoldering phase combustion. Most fuels produced a unimodal distribution during flaming phase and strong biomodal distribution during smoldering phase. The mode of combustion (flaming, mixed and smoldering) could be better distinguished using the slopes in MCE (Modified Combustion Efficiency) vs. geometric mean diameter than only using MCE values.

  15. Intercomparison of fast response commercial gas analysers for nitrous oxide flux measurements under field conditions

    NASA Astrophysics Data System (ADS)

    Rannik, Ü.; Haapanala, S.; Shurpali, N. J.; Mammarella, I.; Lind, S.; Hyvönen, N.; Peltola, O.; Zahniser, M.; Martikainen, P. J.; Vesala, T.

    2015-01-01

    Four gas analysers capable of measuring nitrous oxide (N2O) concentration at a response time necessary for eddy covariance flux measurements were operated from spring until winter 2011 over a field cultivated with reed canary grass (RCG, Phalaris arundinacea, L.), a perennial bioenergy crop in eastern Finland. The instruments were TGA100A (Campbell Scientific Inc.), CW-TILDAS-CS (Aerodyne Research Inc.), N2O / CO-23d (Los Gatos Research Inc.) and QC-TILDAS-76-CS (Aerodyne Research Inc.). The period with high emissions, lasting for about 2 weeks after fertilization in late May, was characterized by an up to 2 orders of magnitude higher emission, whereas during the rest of the campaign the N2O fluxes were small, from 0.01 to 1 nmol m-2 s-1. Two instruments, CW-TILDAS-CS and N2O / CO-23d, determined the N2O exchange with minor systematic difference throughout the campaign, when operated simultaneously. TGA100A produced the cumulatively highest N2O estimates (with 29% higher values during the period when all instruments were operational). QC-TILDAS-76-CS obtained 36% lower fluxes than CW-TILDAS-CS during the first period, including the emission episode, whereas the correspondence with other instruments during the rest of the campaign was good. The reasons for systematic differences were not identified, suggesting further need for detailed evaluation of instrument performance under field conditions with emphasis on stability, calibration and any other factors that can systematically affect the accuracy