fast vme modules: Topics by Science.gov

Sample records for fast vme modules

Online polarimetry of the Nuclotron internal deuteron and proton beams

NASA Astrophysics Data System (ADS)

Isupov, A. Yu

2017-12-01

The spin studies at Nuclotron require fast and precise determination of the deuteron and proton beam polarization. For these purposes new powerful VME-based data acquisition (DAQ) system has been designed for the Deuteron Spin Structure setup placed at the Nuclotron Internal Target Station. The DAQ system is built using the netgraph-based data acquisition and processing framework ngdp. The software dealing with VME hardware is a set of netgraph nodes in form of the loadable kernel modules, so works in the operating system kernel context. The specific for current implementation nodes and user context utilities are described. The online events representation by ROOT classes allows us to generalize code for histograms filling and polarization calculations. The DAQ system was successfully used during 53rd and 54th Nuclotron runs, and their suitability for online polarimetry is demonstrated.
High density, multi-range analog output Versa Module Europa board for control system applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Kundan, E-mail: kundan@iuac.res.in; Das, Ajit Lal

2014-01-15

A new VMEDAC64, 12-bit 64 channel digital-to-analog converter, a Versa Module Europa (VME) module, features 64 analog voltage outputs with user selectable multiple ranges, has been developed for control system applications at Inter University Accelerator Centre. The FPGA (Field Programmable Gate Array) is the module's core, i.e., it implements the DAC control logic and complexity of VMEbus slave interface logic. The VMEbus slave interface and DAC control logic are completely designed and implemented on a single FPGA chip to achieve high density of 64 channels in a single width VME module and will reduce the module count in the controlmore » system applications, and hence will reduce the power consumption and cost of overall system. One of our early design goals was to develop the VME interface such that it can be easily integrated with the peripheral devices and satisfy the timing specifications of VME standard. The modular design of this module reduces the amount of time required to develop other custom modules for control system. The VME slave interface is written as a single component inside FPGA which will be used as a basic building block for any VMEbus interface project. The module offers multiple output voltage ranges depending upon the requirement. The output voltage range can be reduced or expanded by writing range selection bits in the control register. The module has programmable refresh rate and by default hold capacitors in the sample and hold circuit for each channel are charged periodically every 7.040 ms (i.e., update frequency 284 Hz). Each channel has software controlled output switch which disconnects analog output from the field. The modularity in the firmware design on FPGA makes the debugging very easy. On-board DC/DC converters are incorporated for isolated power supply for the analog section of the board.« less
New data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer

NASA Astrophysics Data System (ADS)

Tamii, A.; Sakaguchi, H.; Takeda, H.; Yosoi, M.; Akimune, H.; Fujiwara, M.; Ogata, H.; Tanaka, M.; Togawa, H.

1996-10-01

This paper describes a new data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer at the Research Center for Nuclear Physics (RCNP) in Osaka, Japan. Data are acquired by a Creative Electronic Systems (CES) Starburst, which is a CAMAC auxiliary crate controller equipped with a Digital Equipment Corporation (DEC) J11 microprocessor. The data on the Starburst are transferred to a VME single-board computer. A VME reflective memory module broadcasts the data to other systems through a fiber-optic link. A data transfer rate of 2.0 Mbytes/s between VME modules has been achieved by reflective memories. This rate includes the overhead of buffer management. The overall transfer rate, however, is limited by the performance of the Starburst to about 160 Kbytes/s at maximum. In order to further improve the system performance, we developed a new readout module called the Rapid Data Transfer Module (RDTM). RDTM's transfer data from LeCroy PCOS III's or 4298's, and FERA/FERET's directly to CES 8170 High Speed Memories (HSM) in VME crates, the data transfer rate of the RDTM from PCOS III's to the HSM is about 4 Mbytes/s.
New data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamii, A.; Sakaguchi, H.; Takeda, H.

1996-10-01

This paper describes a new data acquisition system for the focal plane polarimeter of the Grand Raiden spectrometer at the Research Center for Nuclear Physics (RCNP) in Osaka, Japan. Data are acquired by a Creative Electronic Systems (CES) Starburst, which is a CAMAC auxiliary crate controller equipped with a Digital Equipment Corporation (DEC) J11 microprocessor., The data on the Starburst are transferred to a VME single-board computer. A VME reflective memory module broadcasts the data to other systems through a fiber-optic link. A data transfer rate of 2.0 Mbytes/s between VME modules has been achieved by reflective memories. This ratemore » includes the overhead of buffer management. The overall transfer rate, however, is limited by the performance of the Starburst to about 160 Kbytes/s at maximum. In order to further improve the system performance, the authors developed a new readout module called the Rapid Data Transfer Module (RDTM). RDTM`s transfer data from LeCroy PCOS III`s or 4298`s, and FERA/FERET`s directly to CES 8170 High Speed Memories (HSM) in VME crates. The data transfer rate of the RDTM from PCOS III`s to the HSM is about 4 Mbytes/s.« less
A CBLT and MCST capable VME slave interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wuerthwein, F.; Strohman, C.; Honscheid, K.

1996-12-31

We report on the development of a VME slave interface for the CLEO III detector implemented in an ALTERA EPM7256 CPLD. This includes the first implementation of the chained block transfer protocol (CBLT) and multi-cast cycles (MCST) as defined by the VME-P task group of VIPA. Within VME64 there is no operation that guarantees efficient readout of large blocks of data that are sparsely distributed among a series of slave modules in a VME crate. This has led the VME-P task group of VIPA to specify protocols that enable a master to address many slaves at a single address. Whichmore » slave is to drive the data bus is determined by a token passing mechanism that uses the *IACKOUT, *IACKIN daisy chain. This protocol requires no special features from the master besides conformance to VME64. Non-standard features are restricted to the VME slave interface. The CLEO III detector comprises {approximately}400,000 electronic channels that have to be digitized, sparsified, and stored within 20{mu}s in order to incur less than 2% dead time at an anticipated trigger rate of 1000Hz. 95% of these channels are accounted for by only two detector subsystems, the silicon microstrip detector (125,000 channels), and the ring imaging Cerenkov detector (RICH) (230,400 channels). After sparsification either of these two detector subsystems is expected to provide event fragments on the order of 10KBytes, spread over 4, and 8 VME crates, respectively. We developed a chip set that sparsifies, tags, and stores the incoming digital data on the data boards, and includes a VME slave interface that implements MCST and CUT protocols. In this poster, we briefly describe this chip set and then discuss the VME slave interface in detail.« less
A 128-channel Time-to-Digital Converter (TDC) inside a Virtex-5 FPGA on the GANDALF module

NASA Astrophysics Data System (ADS)

Büchele, M.; Fischer, H.; Gorzellik, M.; Herrmann, F.; Königsmann, K.; Schill, C.; Schopferer, S.

2012-03-01

The GANDALF 6U-VME64x/VXS module has been developed for the digitization and real time analysis of detector signals. To perform different applications such as analog-to-digital or time-to-digital conversions, coincidence matrix formation, fast pattern recognition and trigger generation, this module comes with exchangeable analog and digital mezzanine cards. Based on this platform, we present a 128-channel TDC which is implemented in a single Xilinx Virtex-5 FPGA using a shifted clock sampling method. In contrast to common TDC concepts, the input signal is sampled by 16 equidistant phase-shifted clocks. A particular challenge of the design is the minimum skew routing of the input signals to the sampling flip-flops. We present measurement results for the differential nonlinearity and the time resolution of the TDC readout system.
Upgrade of the TOTEM DAQ using the Scalable Readout System (SRS)

NASA Astrophysics Data System (ADS)

Quinto, M.; Cafagna, F.; Fiergolski, A.; Radicioni, E.

2013-11-01

The main goals of the TOTEM Experiment at the LHC are the measurements of the elastic and total p-p cross sections and the studies of the diffractive dissociation processes. At LHC, collisions are produced at a rate of 40 MHz, imposing strong requirements for the Data Acquisition Systems (DAQ) in terms of trigger rate and data throughput. The TOTEM DAQ adopts a modular approach that, in standalone mode, is based on VME bus system. The VME based Front End Driver (FED) modules, host mezzanines that receive data through optical fibres directly from the detectors. After data checks and formatting are applied in the mezzanine, data is retransmitted to the VME interface and to another mezzanine card plugged in the FED module. The VME bus maximum bandwidth limits the maximum first level trigger (L1A) to 1 kHz rate. In order to get rid of the VME bottleneck and improve scalability and the overall capabilities of the DAQ, a new system was designed and constructed based on the Scalable Readout System (SRS), developed in the framework of the RD51 Collaboration. The project aims to increase the efficiency of the actual readout system providing higher bandwidth, and increasing data filtering, implementing a second-level trigger event selection based on hardware pattern recognition algorithms. This goal is to be achieved preserving the maximum back compatibility with the LHC Timing, Trigger and Control (TTC) system as well as with the CMS DAQ. The obtained results and the perspectives of the project are reported. In particular, we describe the system architecture and the new Opto-FEC adapter card developed to connect the SRS with the FED mezzanine modules. A first test bench was built and validated during the last TOTEM data taking period (February 2013). Readout of a set of 3 TOTEM Roman Pot silicon detectors was carried out to verify performance in the real LHC environment. In addition, the test allowed a check of data consistency and quality.
The DISTO data acquisition system at SATURNE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balestra, F.; Bedfer, Y.; Bertini, R.

1998-06-01

The DISTO collaboration has built a large-acceptance magnetic spectrometer designed to provide broad kinematic coverage of multiparticle final states produced in pp scattering. The spectrometer has been installed in the polarized proton beam of the Saturne accelerator in Saclay to study polarization observables in the {rvec p}p {yields} pK{sup +}{rvec Y} (Y = {Lambda}, {Sigma}{sup 0} or Y{sup *}) reaction and vector meson production ({psi}, {omega} and {rho}) in pp collisions. The data acquisition system is based on a VME 68030 CPU running the OS/9 operating system, housed in a single VME crate together with the CAMAC interface, the triplemore » port ECL memories, and four RISC R3000 CPU. The digitization of signals from the detectors is made by PCOS III and FERA front-end electronics. Data of several events belonging to a single Saturne extraction are stored in VME triple-port ECL memories using a hardwired fast sequencer. The buffer, optionally filtered by the RISC R3000 CPU, is recorded on a DLT cassette by DAQ CPU using the on-board SCSI interface during the acceleration cycle. Two UNIX workstations are connected to the VME CPUs through a fast parallel bus and the Local Area Network. They analyze a subset of events for on-line monitoring. The data acquisition system is able to read and record 3,500 ev/burst in the present configuration with a dead time of 15%.« less
Access to CAMAC from VxWorks and UNIX in DART

DOE Office of Scientific and Technical Information (OSTI.GOV)

Streets, J.; Meadows, J.; Moore, C.

1996-02-01

All High Energy Physics experiments at Fermilab include CAMAC modules which need to be read out for each triggered event. There is also a need to access CAMAC modules for control and monitoring of the experiment. As part of the DART Project the authors have developed a package of software for CAMAC access from UNIX and VxWorks platforms, with support for several hardware interfaces. The authors report on developments for the CES CBD8210 VME to parallel CAMAC, the Hytec VSD2992 VME to serial CAMAC and Jorway 411S SCSI to parallel and serial CAMAC branch drivers, and give a summary ofmore » the timings obtained.« less
Online readout and control unit for high-speed/high resolution readout of silicon tracking detectors

NASA Astrophysics Data System (ADS)

Bürger, J.; Hansen, K.; Lange, W.; Nowak, T.; Prell, S.; Zimmermann, W.

1997-02-01

We are describing a high speed VME readout and control module developed and presently working at the H1 experiment at DESY in Hamburg. It has the capability to read out 4 × 2048 analogue data channels at sampling rates up to 10 MHz with a dynamic input range of 1 V. The nominal resolution of the A/D converters can be adjusted between 8 and 12 bit. At the latter resolution we obtain signal-to-noise ratio better than 61.4 dB at a conversion rate of 5 MSps. At this data rate all 8192 detector channels can be read out to the internal raw data memory and VME interface within about 410 μs and 510 μs, respectively. The pedestal subtracted signals can be analyzed on-line. At a raw data hit occupation of 10%, the VME readout time is 50 μs per module. Each module provides four complementary CMOS signals to control the front-end electronics and four independent sets of power supplies for analogue and digital voltages (10 V, 100 mA) to drive the front-end electronics and for the bias voltage (100 V, 1.2 mA) to assure the full functionality of the detectors and the readout.
Inexpensive read-out for coincident electron spectroscopy with a transmission electron microscope at nanometer scale using micro channel plates and multistrip anodes

NASA Astrophysics Data System (ADS)

Hollander, R. W.; Bom, V. R.; van Eijk, C. W. E.; Faber, J. S.; Hoevers, H.; Kruit, P.

1994-09-01

The elemental composition of a sample at nanometer scale is determined by measurement of the characteristic energy of Auger electrons, emitted in coincidence with incoming primary electrons from a microbeam in a scanning transmission electron microscope (STEM). Single electrons are detected with position sensitive detectors, consisting of MicroChannel Plates (MCP) and MultiStrip Anodes (MSA), one for the energy of the Auger electrons (Auger-detector) and one for the energy loss of primary electrons (EELS-detector). The MSAs are sensed with LeCroy 2735DC preamplifiers. The fast readout is based on LeCroy's PCOS III system. On the detection of a coincidence (Event) energy data of Auger and EELS are combined with timing data to an Event word. Event words are stored in list mode in a VME memory module. Blocks of Event words are scanned by transputers in VME and two-dimensional energy histograms are filled using the timing information to obtain a maximal true/accidental ratio. The resulting histograms are stored on disk of a PC-386, which also controls data taking. The system is designed to handle 10 5 Events per second, 90% of which are accidental. In the histograms the "true" to "accidental" ratio will be 5. The dead time is 15%.
A New Flying Wire System for the Tevatron

NASA Astrophysics Data System (ADS)

Blokland, Willem; Dey, Joseph; Vogel, Greg

1997-05-01

A new Flying Wires system replaces the old system to enhance the analysis of the beam emittance, improve the reliability, and handle the upcoming upgrades of the Tevatron. New VME data acquisition modules and timing modules allow for more bunches to be sampled more precisely. The programming language LabVIEW, running on a Macintosh computer, controls the VME modules and the nuLogic motion board that flies the wires. LabVIEW also analyzes and stores the data, and handles local and remote commands. The new system flies three wires and fits profiles of 72 bunches to a gaussian function within two seconds. A new console application operates the flying wires from any control console. This paper discusses the hardware and software setup, the capabilities and measurement results of the new Flying Wires system.
The Cold Dark Matter Search test stand warm electronics card

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hines, Bruce; /Colorado U., Denver; Hansen, Sten

A card which does the signal processing for four SQUID amplifiers and two charge sensitive channels is described. The card performs the same functions as is presently done with two custom 9U x 280mm Eurocard modules, a commercial multi-channel VME digitizer, a PCI to GPIB interface, a PCI to VME interface and a custom built linear power supply. By integrating these functions onto a single card and using the power over Ethernet standard, the infrastructure requirements for instrumenting a Cold Dark Matter Search (CDMS) detector test stand are significantly reduced.
Design of a ``Digital Atlas Vme Electronics'' (DAVE) module

NASA Astrophysics Data System (ADS)

Goodrick, M.; Robinson, D.; Shaw, R.; Postranecky, M.; Warren, M.

2012-01-01

ATLAS-SCT has developed a new ATLAS trigger card, 'Digital Atlas Vme Electronics' (``DAVE''). The unit is designed to provide a versatile array of interface and logic resources, including a large FPGA. It interfaces to both VME bus and USB hosts. DAVE aims to provide exact ATLAS CTP (ATLAS Central Trigger Processor) functionality, with random trigger, simple and complex deadtime, ECR (Event Counter Reset), BCR (Bunch Counter Reset) etc. being generated to give exactly the same conditions in standalone running as experienced in combined runs. DAVE provides additional hardware and a large amount of free firmware resource to allow users to add or change functionality. The combination of the large number of individually programmable inputs and outputs in various formats, with very large external RAM and other components all connected to the FPGA, also makes DAVE a powerful and versatile FPGA utility card.
A tailored 200 parameter VME based data acquisition system for IBA at the Lund Ion Beam Analysis Facility - Hardware and software

NASA Astrophysics Data System (ADS)

Elfman, Mikael; Ros, Linus; Kristiansson, Per; Nilsson, E. J. Charlotta; Pallon, Jan

2016-03-01

With the recent advances towards modern Ion Beam Analysis (IBA), going from one- or few-parameter detector systems to multi-parameter systems, it has been necessary to expand and replace the more than twenty years old CAMAC based system. A new VME multi-parameter (presently up to 200 channels) data acquisition and control system has been developed and implemented at the Lund Ion Beam Analysis Facility (LIBAF). The system is based on the VX-511 Single Board Computer (SBC), acting as master with arbiter functionality and consists of standard VME modules like Analog to Digital Converters (ADC's), Charge to Digital Converters (QDC's), Time to Digital Converters (TDC's), scaler's, IO-cards, high voltage and waveform units. The modules have been specially selected to support all of the present detector systems in the laboratory, with the option of future expansion. Typically, the detector systems consist of silicon strip detectors, silicon drift detectors and scintillator detectors, for detection of charged particles, X-rays and γ-rays. The data flow of the raw data buffers out from the VME bus to the final storage place on a 16 terabyte network attached storage disc (NAS-disc) is described. The acquisition process, remotely controlled over one of the SBCs ethernet channels, is also discussed. The user interface is written in the Kmax software package, and is used to control the acquisition process as well as for advanced online and offline data analysis through a user-friendly graphical user interface (GUI). In this work the system implementation, layout and performance are presented. The user interface and possibilities for advanced offline analysis are also discussed and illustrated.
An Experiment Support Computer for Externally-Based ISS Payloads

NASA Astrophysics Data System (ADS)

Sell, S. W.; Chen, S. E.

2002-01-01

The Experiment Support Facility - External (ESF-X) is a computer designed for general experiment use aboard the International Space Station (ISS) Truss Site locations. The ESF-X design is highly modular and uses commercial off-the-shelf (COTS) components wherever possible to allow for maximum reconfigurability to meet the needs of almost any payload. The ESF-X design has been developed with the EXPRESS Pallet as the target location and the University of Colorado's Micron Accuracy Deployment Experiment (MADE) as the anticipated first payload and capability driver. Thus the design presented here is configured for structural dynamics and control as well as optics experiments. The ESF-X is a small (58.4 x 48.3 x 17.8") steel and copper enclosure which houses a 14 slot VME card chassis and power supply. All power and data connections are made through a single panel on the enclosure so that only one side of the enclosure must be accessed for nominal operation and servicing activities. This feature also allows convenient access during integration and checkout activities. Because it utilizes a standard VME backplane, ESF-X can make use of the many commercial boards already in production for this standard. Since the VME standard is also heavily used in industrial and military applications, many ruggedized components are readily available. The baseline design includes commercial processors, Ethernet, MIL-STD-1553, and mass storage devices. The main processor board contains four TI 6701 DSPs with a PowerPC based controller. Other standard functions, such as analog-to-digital, digital-to-analog, motor driver, temperature readings, etc., are handled on industry-standard IP modules. Carrier cards, which hold 4 IP modules each, are placed in slots in the VME backplane. A unique, custom IP carrier board with radiation event detectors allows non RAD-hard components to be used in an extended exposure environment. Thermal control is maintained by conductive cooling through the copper floor of the enclosure. All components, including the VME backplane, are thermally connected to the floor. The VME chassis can accept both conduction-cooled and convection cooled cards; non-conduction-cooled cards are simply thermal-strapped to the VME chassis. The current ESF-X configuration provides 44 high-rate A/D, 48 low-rate temperature RTDs, 32 digital IO channels (DIO), as well as drivers for digital position encoders, video frame grabbers, an optical interferometry system, stepper motors, paraffin actuators, high torque DC brushless motors, and piezoelectric actuators based on capability demands derived from the MADE program. ESF-X is presently in the critical design phase; potential users are welcome to submit comments and capability requests.
A Front-End electronics board for single photo-electron timing and charge from MaPMT

NASA Astrophysics Data System (ADS)

Giordano, F.; Breton, D.; Beigbeder, C.; De Robertis, G.; Fusco, P.; Gargano, F.; Liuzzi, R.; Loparco, F.; Mazziotta, M. N.; Rizzi, V.; Tocut, V.

2013-08-01

A Front-End (FE) design based on commercial operational amplifiers has been developed to read-out signals from a Multianode PhotoMultiplier Tube (MaPMT). The overall design has been optimised for single photo-electron signal from the Hamamatsu H8500. The signal is collected by a current sensitive preamplifier and then it is fed into both a ECL fast discriminator and a shaper for analog output readout in differential mode. The analog signal and the digital gates are then registered on VME ADC and TDC modules respectively. Performances in terms of linearity, gain and timing resolution will be discussed, presenting results obtained on a test bench with differentiated step voltage inputs and also with a prototype electronic board plugged into the H8500 PMT illuminated by a picosecond laser.
A Timer for Synchronous Digital Systems

NASA Technical Reports Server (NTRS)

McKenney, Elizabeth; Irwin, Philip

2003-01-01

The Real-Time Interferometer Control Systems Testbed (RICST) timing board is a VersaModule Eurocard (VME)-based board that can generate up to 16 simultaneous, phase-locked timing signals at a rate defined by the user. It can also generate all seven VME interrupt requests (IRQs). The RICST timing board is suitable mainly for robotic, aerospace, and real-time applications. Several circuit boards on the market are capable of generating periodic IRQs. Most are associated with Global Positioning System (GPS) receivers and Inter Range Instrumentation Group (IRIG) time-code generators, whereas this board uses either an internal VME clock or an externally generated clock signal to synchronize multiple components of the system. The primary advantage of this board is that there is no discernible jitter in the output clock waveforms because the signals are divided down from a high-frequency clock signal instead of being phase-locked from a lower frequency. The primary disadvantage to this board, relative to other periodic-IRQ-generating boards, is that it is more difficult to synchronize the system to wall clock time.
Electronics for a prototype variable field of view PET camera using the PMT-quadrant-sharing detector array

NASA Astrophysics Data System (ADS)

Li, H.; Wong, Wai-Hoi; Zhang, N.; Wang, J.; Uribe, J.; Baghaei, H.; Yokoyama, S.

1999-06-01

Electronics for a prototype high-resolution PET camera with eight position-sensitive detector modules has been developed. Each module has 16 BGO (Bi/sub 4/Ge/sub 3/O/sub 12/) blocks (each block is composed of 49 crystals). The design goals are component and space reduction. The electronics is composed of five parts: front-end analog processing, digital position decoding, fast timing, coincidence processing and master data acquisition. The front-end analog circuit is a zone-based structure (each zone has 3/spl times/3 PMTs). Nine ADCs digitize integration signals of an active zone identified by eight trigger clusters; each cluster is composed of six photomultiplier tubes (PMTs). A trigger corresponding to a gamma ray is sent to a fast timing board to obtain a time-mark, and the nine digitized signals are passed to the position decoding board, where a real block (four PMTs) can be picked out from the zone for position decoding. Lookup tables are used for energy discrimination and to identify the gamma-hit crystal location. The coincidence board opens a 70-ns initial timing window, followed by two 20-ns true/accidental time-mark lookup table windows. The data output from the coincidence board can be acquired either in sinogram mode or in list mode with a Motorola/IRONICS VME-based system.
Flexible programmable logic module

DOEpatents

Robertson, Perry J.; Hutchinson, Robert L.; Pierson, Lyndon G.

2001-01-01

The circuit module of this invention is a VME board containing a plurality of programmable logic devices (PLDs), a controlled impedance clock tree, and interconnecting buses. The PLDs are arranged to permit systolic processing of a problem by offering wide data buses and a plurality of processing nodes. The board contains a clock reference and clock distribution tree that can drive each of the PLDs with two critically timed clock references. External clock references can be used to drive additional circuit modules all operating from the same synchronous clock reference.

The GANDALF 128-Channel Time-to-Digital Converter

NASA Astrophysics Data System (ADS)

Büchele, M.; Fischer, H.; Herrmann, F.; Königsmann, K.; Schill, C.; Schopferer, S.

The GANDALF 6U-VME64x/VXS module has been designed to cope with a variety of readout tasks in high energy and nuclear physics experiments, in particular the COMPASS experiment at CERN. The exchangeable mezzanine cards allow for an employment of the system in very different applications such as analog-to-digital or time-to-digital conversions, coincidence matrix formation, fast pattern recognition or fast trigger generation. Based on this platform, we present a 128-channel TDC which is implemented in a single Xilinx Virtex-5 FPGA using a shifted clock sampling method. In this concept each input signal is continuously sampled by 16 flip-flops using equidistant phase-shifted clocks. Compared to previous FPGA designs, usually based on delay lines and comprising few TDC channels with resolutions in the order of 10 ps, our design permits the implementation of a large number of TDC channels with a resolution of 64 ps in a single FPGA. Predictable placement of logic components and uniform routing inside the FPGA fabric is a particular challenge of this design. We present measurement results for the time resolution and the nonlinearity of the TDC readout system.
An Experimental Testbed for a Free-Floating Manipulator

DTIC Science & Technology

1993-12-01

brushless servo amplifiers are four quadrant , 20 kHz PWM amplifiers that provide economical control of brushless motors rated from 1/3 to 2 Hp shaft Watts...backplanes that came out of the Versa-Module- Europa consortium [Ref. 15]. The VME is a bus that acts as the path and translator of information between
Signal processing and general purpose data acquisition system for on-line tomographic measurements

NASA Astrophysics Data System (ADS)

Murari, A.; Martin, P.; Hemming, O.; Manduchi, G.; Marrelli, L.; Taliercio, C.; Hoffmann, A.

1997-01-01

New analog signal conditioning electronics and data acquisition systems have been developed for the soft x-ray and bolometric tomography diagnostic in the reverse field pinch experiment (RFX). For the soft x-ray detectors the analog signal processing includes a fully differential current to voltage conversion, with up to a 200 kHz bandwidth. For the bolometers, a 50 kHz carrier frequency amplifier allows a maximum bandwidth of 10 kHz. In both cases the analog signals are digitized with a 1 MHz sampling rate close to the diagnostic and are transmitted via a transparent asynchronous xmitter/receiver interface (TAXI) link to purpose built Versa Module Europa (VME) modules which perform data acquisition. A software library has been developed for data preprocessing and tomographic reconstruction. It has been written in C language and is self-contained, i.e., no additional mathematical library is required. The package is therefore platform-free: in particular it can perform online analysis in a real-time application, such as continuous display and feedback, and is portable for long duration fusion or other physical experiments. Due to the modular organization of the library, new preprocessing and analysis modules can be easily integrated in the environment. This software is implemented in RFX over three different platforms: open VMS, digital Unix, and VME 68040 CPU.
Soft Real-Time PID Control on a VME Computer

NASA Technical Reports Server (NTRS)

Karayan, Vahag; Sander, Stanley; Cageao, Richard

2007-01-01

microPID (uPID) is a computer program for real-time proportional + integral + derivative (PID) control of a translation stage in a Fourier-transform ultraviolet spectrometer. microPID implements a PID control loop over a position profile at sampling rate of 8 kHz (sampling period 125microseconds). The software runs in a strippeddown Linux operating system on a VersaModule Eurocard (VME) computer operating in real-time priority queue using an embedded controller, a 16-bit digital-to-analog converter (D/A) board, and a laser-positioning board (LPB). microPID consists of three main parts: (1) VME device-driver routines, (2) software that administers a custom protocol for serial communication with a control computer, and (3) a loop section that obtains the current position from an LPB-driver routine, calculates the ideal position from the profile, and calculates a new voltage command by use of an embedded PID routine all within each sampling period. The voltage command is sent to the D/A board to control the stage. microPID uses special kernel headers to obtain microsecond timing resolution. Inasmuch as microPID implements a single-threaded process and all other processes are disabled, the Linux operating system acts as a soft real-time system.
Custom electronic subsystems for the laboratory telerobotic manipulator

NASA Technical Reports Server (NTRS)

Glassell, R. L.; Butler, P. L.; Rowe, J. C.; Zimmermann, S. D.

1990-01-01

The National Aeronautics and Space Administration (NASA) Space Station Program presents new opportunities for the application of telerobotic and robotic systems. The Laboratory Telerobotic Manipulator (LTM) is a highly advanced 7 degrees-of-freedom (DOF) telerobotic/robotic manipulator. It was developed and built for the Automation Technology Branch at NASA's Langley Research Center (LaRC) for work in research and to demonstrate ground-based telerobotic manipulator system hardware and software systems for future NASA applications in the hazardous environment of space. The LTM manipulator uses an embedded wiring design with all electronics, motor power, and control and communication cables passing through the pitch-yaw differential joints. This design requires the number of cables passing through the pitch/yaw joint to be kept to a minimum. To eliminate the cables needed to carry each pitch-yaw joint's sensor data to the VME control computers, a custom-embedded electronics package for each manipulator joint was developed. The electronics package collects and sends the joint's sensor data to the VME control computers over a fiber optic cable. The electronics package consist of five individual subsystems: the VME Link Processor, the Joint Processor and the Joint Processor power supply in the joint module, the fiber optics communications system, and the electronics and motor power cabling.
Slow Controls Using the Axiom M5235BCC

NASA Astrophysics Data System (ADS)

Hague, Tyler

2008-10-01

The Forward Vertex Detector group at PHENIX plans to adopt the Axiom M5235 Business Card Controller for use as slow controls. It is also being evaluated for slow controls on FermiLab e906. This controller features the Freescale MCF5235 microprocessor. It also has three parallel buses, these being the MCU port, BUS port, and enhanced Time Processing Unit (eTPU) port. The BUS port uses a chip select module with three external chip selects to communicate with peripherals. This will be used to communicate with and configure Field Programmable Gate Arrays (FPGAs). The controller also has an Ethernet port which can use several different protocols such as TCP and UDP. This will be used to transfer files with computers on a network. The M5235 Business Card Controller will be placed in a VME crate along with VME card and a Spartan-3 FPGA.
A VME-based software trigger system using UNIX processors

NASA Astrophysics Data System (ADS)

Atmur, Robert; Connor, David F.; Molzon, William

1997-02-01

We have constructed a distributed computing platform with eight processors to assemble and filter data from digitization crates. The filtered data were transported to a tape-writing UNIX computer via ethernet. Each processor ran a UNIX operating system and was installed in its own VME crate. Each VME crate contained dual-port memories which interfaced with the digitizers. Using standard hardware and software (VME and UNIX) allows us to select from a wide variety of non-proprietary products and makes upgrades simpler, if they are necessary.
Marine Vessel Traffic System

DTIC Science & Technology

2001-06-19

Queue Get Put The MutexQ module provides primitive queue operations which synchronize access to the queues and ensure queue structure integrity...interface provides for synchronous data rates ranging from 64 Kbps to 1.536 Mbps, while an RS-232 interface accommodates asynchronous data up to...interface VME Communications processor 57 and 8-channel serial I/O board. This board set provides a 68040 processor and 8-channels of synchronous
Cost effective, high performance transient recorder systems, utilizing the latest ADC`s, S/H`s, memories and PLA`s; Final report, May 14, 1987--February 14, 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joerger, F. A.

1990-02-01

This project was to develop five transient recorder modules of various speeds and features. Four of the modules; TR200, 200MHZ recorder; TR2/25, Dual 25MHZ recorder; TR1012, 10MHZ, 12 bit recorder, and the ADC3216, 32 channel, 16 bit recorder were developed in the international CAMAC standard. The fifth unit, VTR1, 25MHZ recorder was packaged in the VME standard. Three of the modules, Models TR200, TR2/25 and VTR1 are already in Phase 3. The ADC3216 has been prototyped and successfully evaluated by a number of customers. The last module, Model TR1012, has been completely designed and the artwork completed. This module willmore » undergo tests shortly. 4 figs.« less
Lessons Learned Using COTS Electronics for the International Space Station Radiation Environment

NASA Technical Reports Server (NTRS)

Blumer, John H.; Roth, A. (Technical Monitor)

2001-01-01

The mantra of 'Faster, Better, Cheaper' has to a large degree been interpreted as using Commercial Off-the-Shelf (COTS) components and/or circuit boards. One of the first space applications to actually use COTS in space along with radiation performance requirements was the Expedite the Processing of Experiments to Space Station (EXPRESS) Rack program, for the International Space Station (ISS). In order to meet the performance, cost and schedule targets, military grade Versa Module Eurocard (VME) was selected as the baseline design for the main computer, the Rack Interface Controller (RIC). VME was chosen as the computer backplane because of the large variety of military grade boards available, which were designed to meet the military environmental specifications (thermal, shock, vibration, etc.). These boards also have a paper pedigree in regards to components. Since these boards exceeded most ISS environmental requirements, it was reasoned using COTS mid-grade VME boards, as opposed to designing custom boards could save significant time and money. It was recognized up front the radiation environment of ISS, while benign compared to many space flight applications, would be the main challenge to using COTS. Thus in addition to selecting vendors on how well their boards met the usual performance and environmental specifications, the board's parts lists were reviewed on how well they would perform in the ISS radiation environment. However, issues with verifying that the available radiation test data was applicable to the actual part used, vendor part design changes and the fact most parts did not have valid test data soon complicated board and part selection in regards to radiation.
Conference on Real-Time Computer Applications in Nuclear, Particle and Plasma Physics, 6th, Williamsburg, VA, May 15-19, 1989, Proceedings

NASA Technical Reports Server (NTRS)

Pordes, Ruth (Editor)

1989-01-01

Papers on real-time computer applications in nuclear, particle, and plasma physics are presented, covering topics such as expert systems tactics in testing FASTBUS segment interconnect modules, trigger control in a high energy physcis experiment, the FASTBUS read-out system for the Aleph time projection chamber, a multiprocessor data acquisition systems, DAQ software architecture for Aleph, a VME multiprocessor system for plasma control at the JT-60 upgrade, and a multiasking, multisinked, multiprocessor data acquisition front end. Other topics include real-time data reduction using a microVAX processor, a transputer based coprocessor for VEDAS, simulation of a macropipelined multi-CPU event processor for use in FASTBUS, a distributed VME control system for the LISA superconducting Linac, a distributed system for laboratory process automation, and a distributed system for laboratory process automation. Additional topics include a structure macro assembler for the event handler, a data acquisition and control system for Thomson scattering on ATF, remote procedure execution software for distributed systems, and a PC-based graphic display real-time particle beam uniformity.
A CAMAC-VME-Macintosh data acquisition system for nuclear experiments

NASA Astrophysics Data System (ADS)

Anzalone, A.; Giustolisi, F.

1989-10-01

A multiprocessor system for data acquisition and analysis in low-energy nuclear physics has been realized. The system is built around CAMAC, the VMEbus, and the Macintosh PC. Multiprocessor software has been developed, using RTF, MACsys, and CERN cross-software. The execution of several programs that run on several VME CPUs and on an external PC is coordinated by a mailbox protocol. No operating system is used on the VME CPUs. The hardware, software, and system performance are described.
Cam-driven monochromator for QEXAFS

NASA Astrophysics Data System (ADS)

Caliebe, W. A.; So, I.; Lenhard, A.; Siddons, D. P.

2006-11-01

We have developed a cam-drive for quickly tuning the energy of an X-ray monochromator through an X-ray absorption edge for quick extended X-ray absorption spectroscopy (QEXAFS). The data are collected using a 4-channel, 12-bit multiplexed VME analog to digital converter and a VME angle encoder. The VME crate controller runs a real-time operating system. This system is capable of collecting 2 EXAFS-scans in 1 s with an energy stability of better than 1 eV. Additional improvements to increase the speed and the energy stability are under way.
VMEbus based computer and real-time UNIX as infrastructure of DAQ

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yasu, Y.; Fujii, H.; Nomachi, M.

1994-12-31

This paper describes what the authors have constructed as the infrastructure of data acquisition system (DAQ). The paper reports recent developments concerned with HP VME board computer with LynxOS (HP742rt/HP-RT) and Alpha/OSF1 with VMEbus adapter. The paper also reports current status of developing a Benchmark Suite for Data Acquisition (DAQBENCH) for measuring not only the performance of VME/CAMAC access but also that of the context switching, the inter-process communications and so on, for various computers including Workstation-based systems and VME board computers.
Development of a Production Ready Automated Wire Delivery System

NASA Technical Reports Server (NTRS)

1997-01-01

The current development effort is a Phase 3 research study entitled "A Production Ready Automated Wire Delivery System", contract number NAS8-39933, awarded to Nichols Research Corporation (NRC). The goals of this research study were to production harden the existing Automated Wire Delivery (AWDS) motion and sensor hardware and test the modified AWDS in a range of welding applications. In addition, the prototype AWDS controller would be moved to the VME bus platform by designing, fabricating and testing a single board VME bus AWDS controller. This effort was to provide an AWDS that could transition from the laboratory environment to production operations. The project was performed in two development steps. Step 1 modified and tested an improved MWG. Step 2 developed and tested the AWDS single board VME bus controller. Step 3 installed the Wire Pilot in a Weld Controller with the imbedded VME bus controller.
RASSP signal processing architectures

NASA Astrophysics Data System (ADS)

Shirley, Fred; Bassett, Bob; Letellier, J. P.

1995-06-01

The rapid prototyping of application specific signal processors (RASSP) program is an ARPA/tri-service effort to dramatically improve the process by which complex digital systems, particularly embedded signal processors, are specified, designed, documented, manufactured, and supported. The domain of embedded signal processing was chosen because it is important to a variety of military and commercial applications as well as for the challenge it presents in terms of complexity and performance demands. The principal effort is being performed by two major contractors, Lockheed Sanders (Nashua, NH) and Martin Marietta (Camden, NJ). For both, improvements in methodology are to be exercised and refined through the performance of individual 'Demonstration' efforts. The Lockheed Sanders' Demonstration effort is to develop an infrared search and track (IRST) processor. In addition, both contractors' results are being measured by a series of externally administered (by Lincoln Labs) six-month Benchmark programs that measure process improvement as a function of time. The first two Benchmark programs are designing and implementing a synthetic aperture radar (SAR) processor. Our demonstration team is using commercially available VME modules from Mercury Computer to assemble a multiprocessor system scalable from one to hundreds of Intel i860 microprocessors. Custom modules for the sensor interface and display driver are also being developed. This system implements either proprietary or Navy owned algorithms to perform the compute-intensive IRST function in real time in an avionics environment. Our Benchmark team is designing custom modules using commercially available processor ship sets, communication submodules, and reconfigurable logic devices. One of the modules contains multiple vector processors optimized for fast Fourier transform processing. Another module is a fiberoptic interface that accepts high-rate input data from the sensors and provides video-rate output data to a display. This paper discusses the impact of simulation on choosing signal processing algorithms and architectures, drawing from the experiences of the Demonstration and Benchmark inter-company teams at Lockhhed Sanders, Motorola, Hughes, and ISX.
A DSP equipped digitizer for online analysis of nuclear detector signals

NASA Astrophysics Data System (ADS)

Pasquali, G.; Ciaranfi, R.; Bardelli, L.; Bini, M.; Boiano, A.; Giannelli, F.; Ordine, A.; Poggi, G.

2007-01-01

In the framework of the NUCL-EX collaboration, a DSP equipped fast digitizer has been implemented and it has now reached the production stage. Each sampling channel is implemented on a separate daughter-board to be plugged on a VME mother-board. Each channel features a 12-bit, 125 MSamples/s ADC and a Digital Signal Processor (DSP) for online analysis of detector signals. A few algorithms have been written and successfully tested on detectors of different types (scintillators, solid-state, gas-filled), implementing pulse shape discrimination, constant fraction timing, semi-Gaussian shaping, gated integration.
Development of a Unix/VME data acquisition system

NASA Astrophysics Data System (ADS)

Miller, M. C.; Ahern, S.; Clark, S. M.

1992-01-01

The current status of a Unix-based VME data acquisition development project is described. It is planned to use existing Fortran data collection software to drive the existing CAMAC electronics via a VME CAMAC branch driver card and associated Daresbury Unix driving software. The first usable Unix driver has been written and produces single-action CAMAC cycles from test software. The data acquisition code has been implemented in test mode under Unix with few problems and effort is now being directed toward finalizing calls to the CAMAC-driving software and ultimate evaluation of the complete system.
A systematic approach towards the identification and protection of vulnerable marine ecosystems

USGS Publications Warehouse

Ardron, Jeff A.; Clark, Malcolm R.; Penney, Andrew J.; Hourigan, Thomas F.; Rowden, Ashley A.; Dunstan, Piers K.; Watling, Les; Shank, Timothy M.; Tracey, Di M.; Dunn, Matthew R.; Parker, Steven J.

2014-01-01

The United Nations General Assembly in 2006 and 2009 adopted resolutions that call for the identification and protection of vulnerable marine ecosystems (VMEs) from significant adverse impacts of bottom fishing. While general criteria have been produced, there are no guidelines or protocols that elaborate on the process from initial identification through to the protection of VMEs. Here, based upon an expert review of existing practices, a 10-step framework is proposed: (1) Comparatively assess potential VME indicator taxa and habitats in a region; (2) determine VME thresholds; (3) consider areas already known for their ecological importance; (4) compile information on the distributions of likely VME taxa and habitats, as well as related environmental data; (5) develop predictive distribution models for VME indicator taxa and habitats; (6) compile known or likely fishing impacts; (7) produce a predicted VME naturalness distribution (areas of low cumulative impacts); (8) identify areas of higher value to user groups; (9) conduct management strategy evaluations to produce trade-off scenarios; (10) review and re-iterate, until spatial management scenarios are developed that fulfil international obligations and regional conservation and management objectives. To date, regional progress has been piecemeal and incremental. The proposed 10-step framework combines these various experiences into a systematic approach.
Physical versus Virtual Manipulative Experimentation in Physics Learning

ERIC Educational Resources Information Center

Zacharia, Zacharias C.; Olympiou, Georgios

2011-01-01

The aim of this study was to investigate whether physical or virtual manipulative experimentation can differentiate physics learning. There were four experimental conditions, namely Physical Manipulative Experimentation (PME), Virtual Manipulative Experimentation (VME), and two sequential combinations of PME and VME, as well as a control condition…

Integrated tests of a high speed VXS switch card and 250 MSPS flash ADCs

DOE Office of Scientific and Technical Information (OSTI.GOV)

H. Dong, C. Cuevas, D. Curry, E. Jastrzembski, F. Barbosa, J. Wilson, M. Taylor, B. Raydo

2008-01-01

High trigger rate nuclear physics experiments proposed for the 12 GeV upgrade at the Thomas Jefferson National Accelerator Facility create a need for new high speed digital systems for energy summing. Signals from electronic detectors will be captured with the Jefferson Lab FADC module, which collects and processes data from 16 charged particle sensors with 10 or 12 bit resolution at 250 MHz sample rate. Up to sixteen FADC modules transfer energy information to a central energy summing module for each readout crate. The sums from the crates are combined to form a global energy sum that is used tomore » trigger data readout for all modules. The Energy Sum module and FADC modules have been designed using the VITA-41 VME64 switched serial (VXS) standard. The VITA- 41 standard defines payload and switch slot module functions, and offers an elegant engineered solution for Multi-Gigabit serial transmission on a standard VITA-41 backplane. The Jefferson Lab Energy Sum module receives data serially at a rate of up to 6 Giga-bits per second from the FADC modules. Both FADC and Energy Sum modules have been designed and assembled and this paper describes the integrated tests using both high speed modules in unison« less
A MOdular System for Acquisition, Interface and Control (MOSAIC) of detectors and their related electronics for high energy physics experiment

NASA Astrophysics Data System (ADS)

Robertis, G. De; Fanizzi, G.; Loddo, F.; Manzari, V.; Rizzi, M.

2018-02-01

In this work the MOSAIC ("MOdular System for Acquisition, Interface and Control") board, designed for the readout and testing of the pixel modules for the silicon tracker upgrade of the ALICE (A Large Ion Collider Experiment) experiment at teh CERN LHC, is described. It is based on an Artix7 Field Programmable Gate Array device by Xilinx and is compliant with the six unit "Versa Modular Eurocard" standard (6U-VME) for easy housing in a standard VMEbus crate from which it takes only power supplies and cooling.
Specifications and implementation of the RT MHD control system for the EC launcher of FTU

NASA Astrophysics Data System (ADS)

Galperti, C.; Alessi, E.; Boncagni, L.; Bruschi, A.; Granucci, G.; Grosso, A.; Iannone, F.; Marchetto, C.; Nowak, S.; Panella, M.; Sozzi, C.; Tilia, B.

2012-09-01

To perform real time plasma control experiments using EC heating waves by using the new fast launcher installed on FTU a dedicated data acquisition and elaboration system has been designed recently. A prototypical version of the acquisition/control system has been recently developed and will be tested on FTU machine in its next experimental campaign. The open-source framework MARTe (Multi-threaded Application Real-Time executor) on Linux/RTAI real-time operating system has been chosen as software platform to realize the control system. Standard open-architecture industrial PCs, based either on VME bus and CompactPCI bus equipped with standard input/output cards are the chosen hardware platform.
VME rollback hardware for time warp multiprocessor systems

NASA Technical Reports Server (NTRS)

Robb, Michael J.; Buzzell, Calvin A.

1992-01-01

The purpose of the research effort is to develop and demonstrate innovative hardware to implement specific rollback and timing functions required for efficient queue management and precision timekeeping in multiprocessor discrete event simulations. The previously completed phase 1 effort demonstrated the technical feasibility of building hardware modules which eliminate the state saving overhead of the Time Warp paradigm used in distributed simulations on multiprocessor systems. The current phase 2 effort will build multiple pre-production rollback hardware modules integrated with a network of Sun workstations, and the integrated system will be tested by executing a Time Warp simulation. The rollback hardware will be designed to interface with the greatest number of multiprocessor systems possible. The authors believe that the rollback hardware will provide for significant speedup of large scale discrete event simulation problems and allow multiprocessors using Time Warp to dramatically increase performance.
Kernel Density Surface Modelling as a Means to Identify Significant Concentrations of Vulnerable Marine Ecosystem Indicators

PubMed Central

Kenchington, Ellen; Murillo, Francisco Javier; Lirette, Camille; Sacau, Mar; Koen-Alonso, Mariano; Kenny, Andrew; Ollerhead, Neil; Wareham, Vonda; Beazley, Lindsay

2014-01-01

The United Nations General Assembly Resolution 61/105, concerning sustainable fisheries in the marine ecosystem, calls for the protection of vulnerable marine ecosystems (VME) from destructive fishing practices. Subsequently, the Food and Agriculture Organization (FAO) produced guidelines for identification of VME indicator species/taxa to assist in the implementation of the resolution, but recommended the development of case-specific operational definitions for their application. We applied kernel density estimation (KDE) to research vessel trawl survey data from inside the fishing footprint of the Northwest Atlantic Fisheries Organization (NAFO) Regulatory Area in the high seas of the northwest Atlantic to create biomass density surfaces for four VME indicator taxa: large-sized sponges, sea pens, small and large gorgonian corals. These VME indicator taxa were identified previously by NAFO using the fragility, life history characteristics and structural complexity criteria presented by FAO, along with an evaluation of their recovery trajectories. KDE, a non-parametric neighbour-based smoothing function, has been used previously in ecology to identify hotspots, that is, areas of relatively high biomass/abundance. We present a novel approach of examining relative changes in area under polygons created from encircling successive biomass categories on the KDE surface to identify “significant concentrations” of biomass, which we equate to VMEs. This allows identification of the VMEs from the broader distribution of the species in the study area. We provide independent assessments of the VMEs so identified using underwater images, benthic sampling with other gear types (dredges, cores), and/or published species distribution models of probability of occurrence, as available. For each VME indicator taxon we provide a brief review of their ecological function which will be important in future assessments of significant adverse impact on these habitats here and elsewhere. PMID:25289667
Kernel density surface modelling as a means to identify significant concentrations of vulnerable marine ecosystem indicators.

PubMed

Kenchington, Ellen; Murillo, Francisco Javier; Lirette, Camille; Sacau, Mar; Koen-Alonso, Mariano; Kenny, Andrew; Ollerhead, Neil; Wareham, Vonda; Beazley, Lindsay

2014-01-01

The United Nations General Assembly Resolution 61/105, concerning sustainable fisheries in the marine ecosystem, calls for the protection of vulnerable marine ecosystems (VME) from destructive fishing practices. Subsequently, the Food and Agriculture Organization (FAO) produced guidelines for identification of VME indicator species/taxa to assist in the implementation of the resolution, but recommended the development of case-specific operational definitions for their application. We applied kernel density estimation (KDE) to research vessel trawl survey data from inside the fishing footprint of the Northwest Atlantic Fisheries Organization (NAFO) Regulatory Area in the high seas of the northwest Atlantic to create biomass density surfaces for four VME indicator taxa: large-sized sponges, sea pens, small and large gorgonian corals. These VME indicator taxa were identified previously by NAFO using the fragility, life history characteristics and structural complexity criteria presented by FAO, along with an evaluation of their recovery trajectories. KDE, a non-parametric neighbour-based smoothing function, has been used previously in ecology to identify hotspots, that is, areas of relatively high biomass/abundance. We present a novel approach of examining relative changes in area under polygons created from encircling successive biomass categories on the KDE surface to identify "significant concentrations" of biomass, which we equate to VMEs. This allows identification of the VMEs from the broader distribution of the species in the study area. We provide independent assessments of the VMEs so identified using underwater images, benthic sampling with other gear types (dredges, cores), and/or published species distribution models of probability of occurrence, as available. For each VME indicator taxon we provide a brief review of their ecological function which will be important in future assessments of significant adverse impact on these habitats here and elsewhere.
An OS9-UNIX data acquisition system with ECL readout

NASA Astrophysics Data System (ADS)

Ziem, P.; Beschorner, C.; Bohne, W.; Drescher, B.; Friese, T.; Kiehne, T.; Kluge, Ch.

1996-02-01

A new data acquisition system has been developed at the Hahn-Meitner-Institut to handle almost 550 parameters of nuclear physics experiments. The system combines a UNIX host running a portable data buffer router and a VME front-end based on the OS9 real time operating system. Different kinds of pulse analyzers are located in several CAMAC crates which are controlled by the VME system via a VICbus connection. Data readout is performed by means of an ECL daisy chain. Besides controlling CAMAC the main purpose of the VME front-end is event data formatting and histogramming. Using TCP/IP services, the UNIX host receives formatted data packages for data storage and display. During a beam time at the antiproton accelerator LEAR/CERN, the PS208 experiment has accumulated about 100 Gbyte of event data [2
An OS9-UNIX data acquisition system with ECL readout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziem, P.; Beschorner, C.; Bohne, W.

1996-02-01

A new data acquisition system has been developed at the Hahn-Meitner-Institut to handle almost 550 parameters of nuclear physics experiments. The system combines a UNIX host running a portable data buffer router and a VME front-end based on the OS9 real time operating system. Different kinds of pulse analyzers are located in several CAMAC crates which are controlled by the VME system via a VICbus connection. Data readout is performed by means of an ECL daisy chain. Besides controlling CAMAC the main purpose of the VME front-end is event data formatting and histogramming. Using TCP/IP services, the UNIX host receivesmore » formatted data packages for data storage and display. During a beam time at the antiproton accelerator LEAR/CERN, the PS208 experiment has accumulated about 100 Gbyte of event data.« less
The third level trigger and output event unit of the UA1 data-acquisition system

NASA Astrophysics Data System (ADS)

Cittolin, S.; Demoulin, M.; Fucci, A.; Haynes, W.; Martin, B.; Porte, J. P.; Sphicas, P.

1989-12-01

The upgraded UA1 experiment utilizes twelve 3081/E emulators for its third-level trigger system. The system is interfaced to VME, and is controlled by 68000 microprocessor VME boards on the input and output. The output controller communicates with an IBM 9375 mainframe via the CERN-IBM developed VICI interface. The events selected by the emulators are output on IBM-3480 cassettes. The user interface to this system is based on a series of Macintosh personal computer connected to the VME bus. These Macs are also used for developing software for the emulators and for monitoring the entire system. The same configuration has also been used for offline event reconstruction. A description of the system, together with details of both the online and offline modes of operation and an eveluation of its performance are presented.
Fermilab Recycler Ring BPM Upgrade Based on Digital Receiver Technology

NASA Astrophysics Data System (ADS)

Webber, R.; Crisp, J.; Prieto, P.; Voy, D.; Briegel, C.; McClure, C.; West, R.; Pordes, S.; Mengel, M.

2004-11-01

Electronics for the 237 BPMs in the Fermilab Recycler Ring have been upgraded from a log-amplifier based system to a commercially produced digitizer-digital down converter based system. The hardware consists of a pre-amplifier connected to a split-plate BPM, an analog differential receiver-filter module and an 8-channel 80-MHz digital down converter VME board. The system produces position and intensity with a dynamic range of 30 dB and a resolution of ±10 microns. The position measurements are made on 2.5-MHz bunched beam and barrier buckets of the un-bunched beam. The digital receiver system operates in one of six different signal processing modes that include 2.5-MHz average, 2.5-MHz bunch-by-bunch, 2.5-MHz narrow band, unbunched average, un-bunched head/tail and 89-kHz narrow band. Receiver data is acquired on any of up to sixteen clock events related to Recycler beam transfers and other machine activities. Data from the digital receiver board are transferred to the front-end CPU for position and intensity computation on an on-demand basis through the VME bus. Data buffers are maintained for each of the acquisition events and support flash, closed orbit and turn-by-turn measurements. A calibration system provides evaluation of the BPM signal path and application programs.
System architecture of a gallium arsenide one-gigahertz digital IC tester

NASA Technical Reports Server (NTRS)

Fouts, Douglas J.; Johnson, John M.; Butner, Steven E.; Long, Stephen I.

1987-01-01

The design for a 1-GHz digital integrated circuit tester for the evaluation of custom GaAs chips and subsystems is discussed. Technology-related problems affecting the design of a GaAs computer are discussed, with emphasis on the problems introduced by long printed-circuit-board interconnect. High-speed interface modules provide a link between the low-speed microprocessor and the chip under test. Memory-multiplexer and memory-shift register architectures for the storage of test vectors are described in addition to an architecture for local data storage consisting of a long chain of GaAs shift registers. The tester is constructed around a VME system card cage and backplane, and very little high-speed interconnect exists between boards. The tester has a three part self-test consisting of a CPU board confidence test, a main memory confidence test, and a high-speed interface module functional test.
Access to CAMAC from VxWorks and UNIX in DART

DOE Office of Scientific and Technical Information (OSTI.GOV)

Streets, J.; Meadows, J.; Moore, C.

1995-05-01

As part of the DART Project the authors have developed a package of software for CAMAC access from UNIX and VxWorks platforms, with support for several hardware interfaces. They report on developments for the CES CBD8210 VME to parallel CAMAC, the Hytec VSD2992 VME to serial CAMAC and Jorway 411S SCSI to parallel and serial CAMAC branch drivers, and give a summary of the timings obtained.
SPring-8 beamline control system.

PubMed

Ohata, T; Konishi, H; Kimura, H; Furukawa, Y; Tamasaku, K; Nakatani, T; Tanabe, T; Matsumoto, N; Ishii, M; Ishikawa, T

1998-05-01

The SPring-8 beamline control system is now taking part in the control of the insertion device (ID), front end, beam transportation channel and all interlock systems of the beamline: it will supply a highly standardized environment of apparatus control for collaborative researchers. In particular, ID operation is very important in a third-generation synchrotron light source facility. It is also very important to consider the security system because the ID is part of the storage ring and is therefore governed by the synchrotron ring control system. The progress of computer networking systems and the technology of security control require the development of a highly flexible control system. An interlock system that is independent of the control system has increased the reliability. For the beamline control system the so-called standard model concept has been adopted. VME-bus (VME) is used as the front-end control system and a UNIX workstation as the operator console. CPU boards of the VME-bus are RISC processor-based board computers operated by a LynxOS-based HP-RT real-time operating system. The workstation and the VME are linked to each other by a network, and form the distributed system. The HP 9000/700 series with HP-UX and the HP 9000/743rt series with HP-RT are used. All the controllable apparatus may be operated from any workstation.
Concept and realization of a fully configurable and programmable data-acquisition system for the neutron scattering instruments at SINQ

NASA Astrophysics Data System (ADS)

Greuter, U.; Buehler, C.; Rasmussen, P.; Emmenegger, M.; Maden, D.; Koennecke, M.; Schlumpf, N.

We present the basic concept and the realization of our fully configurable data-acquisition hardware for the neutron scattering instruments at SINQ. This system allows collection of the different data entities and event-related signals generated by the various detector units. It offers a variety of synchronization options, including a time-measuring mode for time-of-flight determinations. Based on configurable logic (FPGA, CPLD), event rates up to the MHz range can be processed and transmitted to a programmable online data-reduction system (Histogram Memory). It is implemented on a commercially available VME Power PC module running a real-time operating system (VxWorks).
Design of a Channel Error Simulator using Virtual Instrument Techniques for the Initial Testing of TCP/IP and SCPS Protocols

NASA Technical Reports Server (NTRS)

Horan, Stephen; Wang, Ru-Hai

1999-01-01

There exists a need for designers and developers to have a method to conveniently test a variety of communications parameters for an overall system design. This is no different when testing network protocols as when testing modulation formats. In this report, we discuss a means of providing a networking test device specifically designed to be used for space communications. This test device is a PC-based Virtual Instrument (VI) programmed using the LabVIEW(TM) version 5 software suite developed by National Instruments(TM)TM. This instrument was designed to be portable and usable by others without special, additional equipment. The programming was designed to replicate a VME-based hardware module developed earlier at New Mexico State University (NMSU) and to provide expanded capabilities exceeding the baseline configuration existing in that module. This report describes the design goals for the VI module in the next section and follows that with a description of the design of the VI instrument. This is followed with a description of the validation tests run on the VI. An application of the error-generating VI to networking protocols is then given.
Violence in context: Embracing an ecological approach to violent media exposure.

PubMed

Glackin, Erin; Gray, Sarah A O

2016-12-01

This commentary expands on Anderson, Bushman, Donnerstein, Hummer, and Warburton's agenda for minimizing the impacts of violent media exposure (VME) on youth aggression. We argue that in order to effectively intervene in the development of aggression and other maladaptive traits, researchers and policymakers should take an ecological, developmental psychopathology approach to understanding children's exposure to VME within developmental, relational, environmental, and cultural contexts. Such a framework holds the most promise for identifying at-risk groups, establishing targets of intervention, and testing mechanisms of change.
Access to CAMAC from VxWorks and UNIX in DART

NASA Astrophysics Data System (ADS)

Streets, J.; Meadows, J.; Moore, C.; Pordes, R.; Slimmer, D.; Vittone, M.; Stern, E.

1996-02-01

As part of the DART Project [Data acquisition for the next Generation Fermilab Fixed Target Experiments] we have developed a package of software for CAMAC access from UNIX and VxWorks platforms, with support for several hardware interfaces. We report on developments for the CES CBD8210 VME to parallel CAMAC, the Hytec VSD2992 VME to serial CAMAC and Jorway 411s SCSI to parallel and serial CAMAC branch drivers, and give a summary of the timings obtained.
The contaminant analysis automation robot implementation for the automated laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Younkin, J.R.; Igou, R.E.; Urenda, T.D.

1995-12-31

The Contaminant Analysis Automation (CAA) project defines the automated laboratory as a series of standard laboratory modules (SLM) serviced by a robotic standard support module (SSM). These SLMs are designed to allow plug-and-play integration into automated systems that perform standard analysis methods (SAM). While the SLMs are autonomous in the execution of their particular chemical processing task, the SAM concept relies on a high-level task sequence controller (TSC) to coordinate the robotic delivery of materials requisite for SLM operations, initiate an SLM operation with the chemical method dependent operating parameters, and coordinate the robotic removal of materials from the SLMmore » when its commands and events has been established to allow ready them for transport operations as well as performing the Supervisor and Subsystems (GENISAS) software governs events from the SLMs and robot. The Intelligent System Operating Environment (ISOE) enables the inter-process communications used by GENISAS. CAA selected the Hewlett-Packard Optimized Robot for Chemical Analysis (ORCA) and its associated Windows based Methods Development Software (MDS) as the robot SSM. The MDS software is used to teach the robot each SLM position and required material port motions. To allow the TSC to command these SLM motions, a hardware and software implementation was required that allowed message passing between different operating systems. This implementation involved the use of a Virtual Memory Extended (VME) rack with a Force CPU-30 computer running VxWorks; a real-time multitasking operating system, and a Radiuses PC compatible VME computer running MDS. A GENISAS server on The Force computer accepts a transport command from the TSC, a GENISAS supervisor, over Ethernet and notifies software on the RadiSys PC of the pending command through VMEbus shared memory. The command is then delivered to the MDS robot control software using a Windows Dynamic Data Exchange conversation.« less
A Survey of Recent MARTe Based Systems

NASA Astrophysics Data System (ADS)

Neto, André C.; Alves, Diogo; Boncagni, Luca; Carvalho, Pedro J.; Valcarcel, Daniel F.; Barbalace, Antonio; De Tommasi, Gianmaria; Fernandes, Horácio; Sartori, Filippo; Vitale, Enzo; Vitelli, Riccardo; Zabeo, Luca

2011-08-01

The Multithreaded Application Real-Time executor (MARTe) is a data driven framework environment for the development and deployment of real-time control algorithms. The main ideas which led to the present version of the framework were to standardize the development of real-time control systems, while providing a set of strictly bounded standard interfaces to the outside world and also accommodating a collection of facilities which promote the speed and ease of development, commissioning and deployment of such systems. At the core of every MARTe based application, is a set of independent inter-communicating software blocks, named Generic Application Modules (GAM), orchestrated by a real-time scheduler. The platform independence of its core library provides MARTe the necessary robustness and flexibility for conveniently testing applications in different environments including non-real-time operating systems. MARTe is already being used in several machines, each with its own peculiarities regarding hardware interfacing, supervisory control configuration, operating system and target control application. This paper presents and compares the most recent results of systems using MARTe: the JET Vertical Stabilization system, which uses the Real Time Application Interface (RTAI) operating system on Intel multi-core processors; the COMPASS plasma control system, driven by Linux RT also on Intel multi-core processors; ISTTOK real-time tomography equilibrium reconstruction which shares the same support configuration of COMPASS; JET error field correction coils based on VME, PowerPC and VxWorks; FTU LH reflected power system running on VME, Intel with RTAI.
Determination of an Optimal Commercial Data Bus Architecture for a Flight Data System

NASA Technical Reports Server (NTRS)

Crawford, Kevin; Johnson, Martin; Humphries, Rick (Technical Monitor)

2001-01-01

NASA/Marshall Space Flight Center (MSFC) is continually looking for methods to reduce cost and schedule while keeping the quality of work high. MSFC is NASA's lead center for space transportation and microgravity research. When supporting NASA's programs several decisions concerning the avionics system must be made. Usually many trade studies must be conducted to determine the best ways to meet the customer's requirements. When deciding the flight data system, one of the first trade studies normally conducted is the determination of the data bus architecture. The schedule, cost, reliability, and environments are some of the factors that are reviewed in the determination of the data bus architecture. Based on the studies, the data bus architecture could result in a proprietary data bus or a commercial data bus. The cost factor usually removes the proprietary data bus from consideration. The commercial data bus's range from Versa Module Eurocard (VME) to Compact PCI to STD 32 to PC 104. If cost, schedule and size are prime factors, VME is usually not considered. If the prime factors are cost, schedule, and size then Compact PCI, STD 32 and PC104 are the choices for the data bus architecture. MSFC's center director has funded a study from his discretionary fund to determine an optimal low cost commercial data bus architecture. The goal of the study is to functionally and environmentally test Compact PCI, STD 32 and PC 104 data bus architectures. This paper will summarize the results of the data bus architecture study.

Parallel processor for real-time structural control

NASA Astrophysics Data System (ADS)

Tise, Bert L.

1993-07-01

A parallel processor that is optimized for real-time linear control has been developed. This modular system consists of A/D modules, D/A modules, and floating-point processor modules. The scalable processor uses up to 1,000 Motorola DSP96002 floating-point processors for a peak computational rate of 60 GFLOPS. Sampling rates up to 625 kHz are supported by this analog-in to analog-out controller. The high processing rate and parallel architecture make this processor suitable for computing state-space equations and other multiply/accumulate-intensive digital filters. Processor features include 14-bit conversion devices, low input-to-output latency, 240 Mbyte/s synchronous backplane bus, low-skew clock distribution circuit, VME connection to host computer, parallelizing code generator, and look- up-tables for actuator linearization. This processor was designed primarily for experiments in structural control. The A/D modules sample sensors mounted on the structure and the floating- point processor modules compute the outputs using the programmed control equations. The outputs are sent through the D/A module to the power amps used to drive the structure's actuators. The host computer is a Sun workstation. An OpenWindows-based control panel is provided to facilitate data transfer to and from the processor, as well as to control the operating mode of the processor. A diagnostic mode is provided to allow stimulation of the structure and acquisition of the structural response via sensor inputs.
The DZERO Level 3 Data Acquisition System

NASA Astrophysics Data System (ADS)

Angstadt, R.; Brooijmans, G.; Chapin, D.; Clements, M.; Cutts, D.; Haas, A.; Hauser, R.; Johnson, M.; Kulyavtsev, A.; Mattingly, S. E. K.; Mulders, M.; Padley, P.; Petravick, D.; Rechenmacher, R.; Snyder, S.; Watts, G.

2004-06-01

The DZERO experiment began RunII datataking operation at Fermilab in spring 2001. The physics program of the experiment requires the Level 3 data acquisition (DAQ) system system to handle average event sizes of 250 kilobytes at a rate of 1 kHz. The system routes and transfers event fragments of approximately 1-20 kilobytes from 63 VME crate sources to any of approximately 100 processing nodes. It is built upon a Cisco 6509 Ethernet switch, standard PCs, and commodity VME single board computers (SBCs). The system has been in full operation since spring 2002.
Andic soil features and debris flows in Italy. New perspective towards prediction

NASA Astrophysics Data System (ADS)

Scognamiglio, Solange; Calcaterra, Domenico; Iamarino, Michela; Langella, Giuliano; Orefice, Nadia; Vingiani, Simona; Terribile, Fabio

2016-04-01

Debris flows are dangerous hazards causing fatalities and damage. Previous works have demonstrated that the materials involved by debris flows in Campania (southern Italy) are soils classified as Andosols. These soils have peculiar chemical and physical properties which make them fertile but also vulnerable to landslide. In Italy, andic soil properties are found both in volcanic and non-volcanic mountain ecosystems (VME and NVME). Here, we focused on the assessment of the main chemical and physical properties of the soils in the detachment areas of eight debris flows occurred in NVME of Italy in the last 70 years. Such landslides were selected by consulting the official Italian geodatabase (IFFI Project). Andic properties (by means of ammonium oxalate extractable Fe, Si and Al forms for the calculation of Alo+1/2Feo) were also evaluated and a comparison with soils of VME was performed to assess possible common features. Landslide source areas were characterised by slope gradient ranging from 25° to 50° and lithological heterogeneity of the bedrock. The soils showed similar, i.e. all were very deep, had a moderately thick topsoil with a high organic carbon (OC) content decreasing regularly with depth. The cation exchange capacity trend was generally consistent with the OC and the pH varied from extremely to slightly acid, but increased with depth. Furthermore, the soils had high water retention values both at saturation (0.63 to 0.78 cm3 cm-3) and in the dryer part of the water retention curve, and displayed a prevalent loamy texture. Such properties denote the chemical and physical fertility of the investigated ecosystems. The values of Alo+1/2Feoindicated that the soils had vitric or andic features and can be classified as Andosols. The comparison between NVME soils and those of VME showed similar depth, thickness of soil horizons, and family texture, whereas soil pH, degree of development of andic properties and allophane content were higher for VME soils. Such results are consistent with the different soil environments; indeed, in VME a continuous soil enrichment of weatherable volcanic glass affects both soil pH and formation of short range order clay minerals. In conclusion, the direct relationship between debris flows and Andosols, previously found in the Campania VME, is confirmed in some NVME. These findings highlight the similarity of the materials involved by debris flows both in VME and NVME and suggest the existence of a pedological control on debris flow initiation. Furthermore, these results encourage a further extension of soil studies to other European mountain ecosystems. The evidence that andic soils may play a crucial role in debris flows initiation in Italy enables to develop a new strategy for debris flows forecasting. For the case of Sarno 1998 landslides, we provide an example of innovative approach exploring the results obtained by combining the spatial distribution of these andic soils with "on the fly" simulation modelling of the soil water balance, using real time weather forecasting data. The obtained results enable to develop promising Geospatial Decision Support Systems to improve our ability to predict debris flows on soil-covered slopes.
Digital Intermediate Frequency Receiver Module For Use In Airborne Sar Applications

DOEpatents

Tise, Bertice L.; Dubbert, Dale F.

2005-03-08

A digital IF receiver (DRX) module directly compatible with advanced radar systems such as synthetic aperture radar (SAR) systems. The DRX can combine a 1 G-Sample/sec 8-bit ADC with high-speed digital signal processor, such as high gate-count FPGA technology or ASICs to realize a wideband IF receiver. DSP operations implemented in the DRX can include quadrature demodulation and multi-rate, variable-bandwidth IF filtering. Pulse-to-pulse (Doppler domain) filtering can also be implemented in the form of a presummer (accumulator) and an azimuth prefilter. An out of band noise source can be employed to provide a dither signal to the ADC, and later be removed by digital signal processing. Both the range and Doppler domain filtering operations can be implemented using a unique pane architecture which allows on-the-fly selection of the filter decimation factor, and hence, the filter bandwidth. The DRX module can include a standard VME-64 interface for control, status, and programming. An interface can provide phase history data to the real-time image formation processors. A third front-panel data port (FPDP) interface can send wide bandwidth, raw phase histories to a real-time phase history recorder for ground processing.
Parallel processor for real-time structural control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tise, B.L.

1992-01-01

A parallel processor that is optimized for real-time linear control has been developed. This modular system consists of A/D modules, D/A modules, and floating-point processor modules. The scalable processor uses up to 1,000 Motorola DSP96002 floating-point processors for a peak computational rate of 60 GFLOPS. Sampling rates up to 625 kHz are supported by this analog-in to analog-out controller. The high processing rate and parallel architecture make this processor suitable for computing state-space equations and other multiply/accumulate-intensive digital filters. Processor features include 14-bit conversion devices, low input-output latency, 240 Mbyte/s synchronous backplane bus, low-skew clock distribution circuit, VME connection tomore » host computer, parallelizing code generator, and look-up-tables for actuator linearization. This processor was designed primarily for experiments in structural control. The A/D modules sample sensors mounted on the structure and the floating-point processor modules compute the outputs using the programmed control equations. The outputs are sent through the D/A module to the power amps used to drive the structure's actuators. The host computer is a Sun workstation. An Open Windows-based control panel is provided to facilitate data transfer to and from the processor, as well as to control the operating mode of the processor. A diagnostic mode is provided to allow stimulation of the structure and acquisition of the structural response via sensor inputs.« less
FAST User Guide

NASA Technical Reports Server (NTRS)

Walatka, Pamela P.; Clucas, Jean; McCabe, R. Kevin; Plessel, Todd; Potter, R.; Cooper, D. M. (Technical Monitor)

1994-01-01

The Flow Analysis Software Toolkit, FAST, is a software environment for visualizing data. FAST is a collection of separate programs (modules) that run simultaneously and allow the user to examine the results of numerical and experimental simulations. The user can load data files, perform calculations on the data, visualize the results of these calculations, construct scenes of 3D graphical objects, and plot, animate and record the scenes. Computational Fluid Dynamics (CFD) visualization is the primary intended use of FAST, but FAST can also assist in the analysis of other types of data. FAST combines the capabilities of such programs as PLOT3D, RIP, SURF, and GAS into one environment with modules that share data. Sharing data between modules eliminates the drudgery of transferring data between programs. All the modules in the FAST environment have a consistent, highly interactive graphical user interface. Most commands are entered by pointing and'clicking. The modular construction of FAST makes it flexible and extensible. The environment can be custom configured and new modules can be developed and added as needed. The following modules have been developed for FAST: VIEWER, FILE IO, CALCULATOR, SURFER, TOPOLOGY, PLOTTER, TITLER, TRACER, ARCGRAPH, GQ, SURFERU, SHOTET, and ISOLEVU. A utility is also included to make the inclusion of user defined modules in the FAST environment easy. The VIEWER module is the central control for the FAST environment. From VIEWER, the user can-change object attributes, interactively position objects in three-dimensional space, define and save scenes, create animations, spawn new FAST modules, add additional view windows, and save and execute command scripts. The FAST User Guide uses text and FAST MAPS (graphical representations of the entire user interface) to guide the user through the use of FAST. Chapters include: Maps, Overview, Tips, Getting Started Tutorial, a separate chapter for each module, file formats, and system administration.
Data acquisition architecture and online processing system for the HAWC gamma-ray observatory

NASA Astrophysics Data System (ADS)

Abeysekara, A. U.; Alfaro, R.; Alvarez, C.; Álvarez, J. D.; Arceo, R.; Arteaga-Velázquez, J. C.; Ayala Solares, H. A.; Barber, A. S.; Baughman, B. M.; Bautista-Elivar, N.; Becerra Gonzalez, J.; Belmont-Moreno, E.; BenZvi, S. Y.; Berley, D.; Bonilla Rosales, M.; Braun, J.; Caballero-Lopez, R. A.; Caballero-Mora, K. S.; Carramiñana, A.; Castillo, M.; Cotti, U.; Cotzomi, J.; de la Fuente, E.; De León, C.; DeYoung, T.; Diaz-Cruz, J.; Diaz Hernandez, R.; Díaz-Vélez, J. C.; Dingus, B. L.; DuVernois, M. A.; Ellsworth, R. W.; Fiorino, D. W.; Fraija, N.; Galindo, A.; Garfias, F.; González, M. M.; Goodman, J. A.; Grabski, V.; Gussert, M.; Hampel-Arias, Z.; Harding, J. P.; Hui, C. M.; Hüntemeyer, P.; Imran, A.; Iriarte, A.; Karn, P.; Kieda, D.; Kunde, G. J.; Lara, A.; Lauer, R. J.; Lee, W. H.; Lennarz, D.; León Vargas, H.; Linares, E. C.; Linnemann, J. T.; Longo Proper, M.; Luna-García, R.; Malone, K.; Marinelli, A.; Marinelli, S. S.; Martinez, O.; Martínez-Castro, J.; Martínez-Huerta, H.; Matthews, J. A. J.; McEnery, J.; Mendoza Torres, E.; Miranda-Romagnoli, P.; Moreno, E.; Mostafá, M.; Nellen, L.; Newbold, M.; Noriega-Papaqui, R.; Oceguera-Becerra, T.; Patricelli, B.; Pelayo, R.; Pérez-Pérez, E. G.; Pretz, J.; Rivière, C.; Rosa-González, D.; Ruiz-Velasco, E.; Ryan, J.; Salazar, H.; Salesa Greus, F.; Sanchez, F. E.; Sandoval, A.; Schneider, M.; Silich, S.; Sinnis, G.; Smith, A. J.; Sparks Woodle, K.; Springer, R. W.; Taboada, I.; Toale, P. A.; Tollefson, K.; Torres, I.; Ukwatta, T. N.; Villaseñor, L.; Weisgarber, T.; Westerhoff, S.; Wisher, I. G.; Wood, J.; Yapici, T.; Yodh, G. B.; Younk, P. W.; Zaborov, D.; Zepeda, A.; Zhou, H.

2018-04-01

The High Altitude Water Cherenkov observatory (HAWC) is an air shower array devised for TeV gamma-ray astronomy. HAWC is located at an altitude of 4100 m a.s.l. in Sierra Negra, Mexico. HAWC consists of 300 Water Cherenkov Detectors, each instrumented with 4 photomultiplier tubes (PMTs). HAWC re-uses the Front-End Boards from the Milagro experiment to receive the PMT signals. These boards are used in combination with Time to Digital Converters (TDCs) to record the time and the amount of light in each PMT hit (light flash). A set of VME TDC modules (128 channels each) is operated in a continuous (dead time free) mode. The TDCs are read out via the VME bus by Single-Board Computers (SBCs), which in turn are connected to a gigabit Ethernet network. The complete system produces ≈500 MB/s of raw data. A high-throughput data processing system has been designed and built to enable real-time data analysis. The system relies on off-the-shelf hardware components, an open-source software technology for data transfers (ZeroMQ) and a custom software framework for data analysis (AERIE). Multiple trigger and reconstruction algorithms can be combined and run on blocks of data in a parallel fashion, producing a set of output data streams which can be analyzed in real time with minimal latency (<5 s). This paper provides an overview of the hardware set-up and an in-depth description of the software design, covering both the TDC data acquisition system and the real-time data processing system. The performance of these systems is also discussed.
Real-time separation of multineuron recordings with a DSP32C signal processor.

PubMed

Gädicke, R; Albus, K

1995-04-01

We have developed a hardware and software package for real-time discrimination of multiple-unit activities recorded simultaneously from multiple microelectrodes using a VME-Bus system. Compared with other systems cited in literature or commercially available, our system has the following advantages. (1) Each electrode is served by its own preprocessor (DSP32C); (2) On-line spike discrimination is performed independently for each electrode. (3) The VME-bus allows processing of data received from 16 electrodes. The digitized (62.5 kHz) spike form is itself used as the model spike; the algorithm allows for comparing and sorting complete wave forms in real time into 8 different models per electrode.
A UNIX SVR4-OS 9 distributed data acquisition for high energy physics

NASA Astrophysics Data System (ADS)

Drouhin, F.; Schwaller, B.; Fontaine, J. C.; Charles, F.; Pallares, A.; Huss, D.

1998-08-01

The distributed data acquisition (DAQ) system developed by the GRPHE (Groupe de Recherche en Physique des Hautes Energies) group is a combination of hardware and software dedicated to high energy physics. The system described here is used in the beam tests of the CMS tracker. The central processor of the system is a RISC CPU hosted in a VME card, running a POSIX compliant UNIX system. Specialized real-time OS9 VME cards perform the instrumentation control. The main data flow goes over a deterministic high speed network. The UNIX system manages a list of OS9 front-end systems with a synchronisation protocol running over a TCP/IP layer.
On-line data analysis and monitoring for H1 drift chambers

NASA Astrophysics Data System (ADS)

Düllmann, Dirk

1992-05-01

The on-line monitoring, slow control and calibration of the H1 central jet chamber uses a VME multiprocessor system to perform the analysis and a connected Macintosh computer as graphical interface to the operator on shift. Task of this system are: - analysis of event data including on-line track search, - on-line calibration from normal events and testpulse events, - control of the high voltage and monitoring of settings and currents, - monitoring of temperature, pressure and mixture of the chambergas. A program package is described which controls the dataflow between data aquisition, differnt VME CPUs and Macintosh. It allows to run off-line style programs for the different tasks.
A Unix SVR-4-OS9 distributed data acquisition for high energy physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drouhin, F.; Schwaller, B.; Fontaine, J.C.

1998-08-01

The distributed data acquisition (DAQ) system developed by the GRPHE (Groupe de Recherche en Physique des Hautes Energies) group is a combination of hardware and software dedicated to high energy physics. The system described here is used in the beam tests of the CMs tracker. The central processor of the system is a RISC CPU hosted in a VME card, running a POSIX compliant UNIX system. Specialized real-time OS9 VME cards perform the instrumentation control. The main data flow goes over a deterministic high speed network. The Unix system manages a list of OS9 front-end systems with a synchronization protocolmore » running over a TCP/IP layer.« less
DOC II 32-bit digital optical computer: optoelectronic hardware and software

NASA Astrophysics Data System (ADS)

Stone, Richard V.; Zeise, Frederick F.; Guilfoyle, Peter S.

1991-12-01

This paper describes current electronic hardware subsystems and software code which support OptiComp's 32-bit general purpose digital optical computer (DOC II). The reader is referred to earlier papers presented in this section for a thorough discussion of theory and application regarding DOC II. The primary optoelectronic subsystems include the drive electronics for the multichannel acousto-optic modulators, the avalanche photodiode amplifier, as well as threshold circuitry, and the memory subsystems. This device utilizes a single optical Boolean vector matrix multiplier and its VME based host controller interface in performing various higher level primitives. OptiComp Corporation wishes to acknowledge the financial support of the Office of Naval Research, the National Aeronautics and Space Administration, the Rome Air Development Center, and the Strategic Defense Initiative Office for the funding of this program under contracts N00014-87-C-0077, N00014-89-C-0266 and N00014-89-C- 0225.
CAMAC throughput of a new RISC-based data acquisition computer at the DIII-D tokamak

NASA Astrophysics Data System (ADS)

Vanderlaan, J. F.; Cummings, J. W.

1993-10-01

The amount of experimental data acquired per plasma discharge at DIII-D has continued to grow. The largest shot size in May 1991 was 49 Mbyte; in May 1992, 66 Mbyte; and in April 1993, 80 Mbyte. The increasing load has prompted the installation of a new Motorola 88100-based MODCOMP computer to supplement the existing core of three older MODCOMP data acquisition CPU's. New Kinetic Systems CAMAC serial highway driver hardware runs on the 88100 VME bus. The new operating system is MODCOMP REAL/IX version of AT&T System V UNIX with real-time extensions and networking capabilities; future plans call for installation of additional computers of this type for tokamak and neutral beam control functions. Experiences with the CAMAC hardware and software will be chronicled, including observation of data throughput. The Enhanced Serial Highway crate controller is advertised as twice as fast as the previous crate controller, and computer I/O speeds are expected to also increase data rates.
Collaborative Software Development Approach Used to Deliver the New Shuttle Telemetry Ground Station

NASA Technical Reports Server (NTRS)

Kirby, Randy L.; Mann, David; Prenger, Stephen G.; Craig, Wayne; Greenwood, Andrew; Morsics, Jonathan; Fricker, Charles H.; Quach, Son; Lechese, Paul

2003-01-01

United Space Alliance (USA) developed and used a new software development method to meet technical, schedule, and budget challenges faced during the development and delivery of the new Shuttle Telemetry Ground Station at Kennedy Space Center. This method, called Collaborative Software Development, enabled KSC to effectively leverage industrial software and build additional capabilities to meet shuttle system and operational requirements. Application of this method resulted in reduced time to market, reduced development cost, improved product quality, and improved programmer competence while developing technologies of benefit to a small company in California (AP Labs Inc.). Many modifications were made to the baseline software product (VMEwindow), which improved its quality and functionality. In addition, six new software capabilities were developed, which are the subject of this article and add useful functionality to the VMEwindow environment. These new software programs are written in C or VXWorks and are used in conjunction with other ground station software packages, such as VMEwindow, Matlab, Dataviews, and PVWave. The Space Shuttle Telemetry Ground Station receives frequency-modulation (FM) and pulse-code-modulated (PCM) signals from the shuttle and support equipment. The hardware architecture (see figure) includes Sun workstations connected to multiple PCM- and FM-processing VersaModule Eurocard (VME) chassis. A reflective memory network transports raw data from PCM Processors (PCMPs) to the programmable digital-to-analog (D/A) converters, strip chart recorders, and analysis and controller workstations.
Preliminary Evaluation of Air Quality Model Performance Utilizing Measurements at the University of Houston Moody Tower and others during the TexAQS-II

NASA Astrophysics Data System (ADS)

Byun, D. W.; Rappenglueck, B.; Lefer, B.

2007-12-01

Accurate meteorological and photochemical modeling efforts are necessary to understand the measurements made during the Texas Air Quality Study (TexAQS-II). The main objective of the study is to understand the meteorological and chemical processes of high ozone and regional haze events in the Eastern Texas, including the Houston-Galveston metropolitan area. Real-time and retrospective meteorological and photochemical model simulations were performed to study key physical and chemical processes in the Houston Galveston Area. In particular, the Vertical Mixing Experiment (VME) at the University of Houston campus was performed on selected days during the TexAQS-II. Results of the MM5 meteorological model and CMAQ air quality model simulations were compared with the VME and other TexAQS-II measurements to understand the interaction of the boundary layer dynamics and photochemical evolution affecting Houston air quality.
MIL-STD-1553 dynamic bus controller/remote terminal hybrid set

NASA Astrophysics Data System (ADS)

Friedman, S. N.

This paper describes the performance, physical and electrical requirements of a Dual Redundant BUS Interface Unit (BIU) acting as a BUS Controller Interface Unit (BCIU) or Remote Terminal Unit (RTU) between a Motorola 68000 VME BUS and MIL-STD-1553B Multiplex Data Bus. A discussion of how the BIU Hybrid set is programmed, and operates as a BCIU or RTU, will be included. This paper will review Dynamic Bus Control and other Mode Code capabilities. The BIU Hybrid Set interfaces to a 68000 Microprocessor with a VME Bus using programmed I/O transfers. This special interface will be discussed along with the internal Dual Access Memory (4K x 16) used to support the data exchanges between the CPU and the BIU Hybrid Set. The hybrid set's physical size and power requirements will be covered. This includes the present Double Eurocard the BIU function is presently being offered on.
Development of the integrated control system for the microwave ion source of the PEFP 100-MeV proton accelerator

NASA Astrophysics Data System (ADS)

Song, Young-Gi; Seol, Kyung-Tae; Jang, Ji-Ho; Kwon, Hyeok-Jung; Cho, Yong-Sub

2012-07-01

The Proton Engineering Frontier Project (PEFP) 20-MeV proton linear accelerator is currently operating at the Korea Atomic Energy Research Institute (KAERI). The ion source of the 100-MeV proton linac needs at least a 100-hour operation time. To meet the goal, we have developed a microwave ion source that uses no filament. For the ion source, a remote control system has been developed by using experimental physics and the industrial control system (EPICS) software framework. The control system consists of a versa module europa (VME) and EPICS-based embedded applications running on a VxWorks real-time operating system. The main purpose of the control system is to control and monitor the operational variables of the components remotely and to protect operators from radiation exposure and the components from critical problems during beam extraction. We successfully performed the operation test of the control system to confirm the degree of safety during the hardware performance.
Beam rider for an Articulated Robot Manipulator (ARM) accurate positioning of long flexible manipulators

NASA Technical Reports Server (NTRS)

Malachowski, M. J.

1990-01-01

Laser beam positioning and beam rider modules were incorporated into the long hollow flexible segment of an articulated robot manipulator (ARM). Using a single laser beam, the system determined the position of the distal ARM endtip, with millimetric precision, in six degrees of freedom, at distances of up to 10 meters. Preliminary designs, using space rated technology for the critical systems, of a two segmented physical ARM, with a single and a dual degree of freedom articulation, were developed, prototyped, and tested. To control the positioning of the physical ARM, an indirect adaptive controller, which used the mismatch between the position of the laser beam under static and dynamic conditions, was devised. To predict the behavior of the system and test the concept, a computer simulation model was constructed. A hierarchical artificially intelligent real time ADA operating system program structure was created. The software was designed for implementation on a dedicated VME bus based Intel 80386 administered parallel processing multi-tasking computer system.
Speckle interferometry. Data acquisition and control for the SPID instrument.

NASA Astrophysics Data System (ADS)

Altarac, S.; Tallon, M.; Thiebaut, E.; Foy, R.

1998-08-01

SPID (SPeckle Imaging by Deconvolution) is a new speckle camera currently under construction at CRAL-Observatoire de Lyon. Its high spectral resolution and high image restoration capabilities open new astrophysical programs. The instrument SPID is composed of four main optical modules which are fully automated and computer controlled by a software written in Tcl/Tk/Tix and C. This software provides an intelligent assistance to the user by choosing observational parameters as a function of atmospheric parameters, computed in real time, and the desired restored image quality. Data acquisition is made by a photon-counting detector (CP40). A VME-based computer under OS9 controls the detector and stocks the data. The intelligent system runs under Linux on a PC. A slave PC under DOS commands the motors. These 3 computers communicate through an Ethernet network. SPID can be considered as a precursor for VLT's (Very Large Telescope, four 8-meter telescopes currently built in Chile by European Southern Observatory) very high spatial resolution camera.
Scintillating fiber-based photon beam profiler for the Jefferson Lab tagged photon beam line

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zorn, C.; Barbosa, F.J.; Freyberger, A.

2000-10-01

A scintillating fiber hodoscope has been built for use as a photon beam profiler in the bremsstrahlung tagged photon beam in Hall B of the Thomas Jefferson National Accelerator Facility (Jefferson Lab). The device consists of a linear array of 64 2-2 mm2 scintillating fibers glued to a corresponding set of light guide fibers. Both fiber types use double-clad technology for maximum intensity. The light guide fibers are gently bent into a square array of holes and air-gap coupled to four compact position-sensitive photomultipliers (16 channel Hamamatsu R5900-M16). Custom electronics amplifies and converts the analog outputs to ECL pulses whichmore » are counted by VME-based scalars. The device consisting of the fibers, photomultipliers, and electronics is sealed within a light-tight aluminum box. Two modules make up a beam imaging 2-D system. The system has been tested successfully during an experimental run« less

6.2-GHz modulated terahertz light detection using fast terahertz quantum well photodetectors.

PubMed

Li, Hua; Wan, Wen-Jian; Tan, Zhi-Yong; Fu, Zhang-Long; Wang, Hai-Xia; Zhou, Tao; Li, Zi-Ping; Wang, Chang; Guo, Xu-Guang; Cao, Jun-Cheng

2017-06-14

The fast detection of terahertz radiation is of great importance for various applications such as fast imaging, high speed communications, and spectroscopy. Most commercial products capable of sensitively responding the terahertz radiation are thermal detectors, i.e., pyroelectric sensors and bolometers. This class of terahertz detectors is normally characterized by low modulation frequency (dozens or hundreds of Hz). Here we demonstrate the first fast semiconductor-based terahertz quantum well photodetectors by carefully designing the device structure and microwave transmission line for high frequency signal extraction. Modulation response bandwidth of gigahertz level is obtained. As an example, the 6.2-GHz modulated terahertz light emitted from a Fabry-Pérot terahertz quantum cascade laser is successfully detected using the fast terahertz quantum well photodetector. In addition to the fast terahertz detection, the technique presented in this work can also be used for optically characterizing the frequency stability of terahertz quantum cascade lasers, heterodyne detections and photomixing applications.
The phase-space dependence of fast-ion interaction with tearing modes

DOE PAGES

Heidbrink, William W.; Bardoczi, Laszlo; Collins, Cami S.; ...

2018-03-19

Modulation of various neutral beam sources probes the interaction of fast ions with tearing modes (TM) in the DIII-D tokamak. As measured by electron cyclotron emission, the (m,n) = (2,1) tearing modes have an island width of ~8 cm and change phase 180 at the q = 2 surface. (Here, m is the poloidal mode number and n is the toroidal mode number.) Deuterium neutral beam injection by six sources with differing injection geometries produces the fast ions. To study the interaction in different parts of phase space, on successive discharges, one of the six sources is modulated at 20more » Hz to populate different fast-ion orbits. The modulation only changes the island width by a few millimeters, implying that any fast-ion effect on mode stability is below detection limits. When compared to the expected signals in the absence of TM-induced transport, both the average and modulated neutron signals deviate, implying that fast-ion transport occurs in much of phase space. Fast-ion D-α (FIDA) measurements detect reductions in signal at wavelengths that are sensitive to counter-passing ions. Neutral particle analyzer data imply poor confinement of trapped fast ions. Lastly, calculations of the expected fast-ion transport that use measured TM properties successfully reproduce the data.« less
The phase-space dependence of fast-ion interaction with tearing modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heidbrink, William W.; Bardoczi, Laszlo; Collins, Cami S.

Modulation of various neutral beam sources probes the interaction of fast ions with tearing modes (TM) in the DIII-D tokamak. As measured by electron cyclotron emission, the (m,n) = (2,1) tearing modes have an island width of ~8 cm and change phase 180 at the q = 2 surface. (Here, m is the poloidal mode number and n is the toroidal mode number.) Deuterium neutral beam injection by six sources with differing injection geometries produces the fast ions. To study the interaction in different parts of phase space, on successive discharges, one of the six sources is modulated at 20more » Hz to populate different fast-ion orbits. The modulation only changes the island width by a few millimeters, implying that any fast-ion effect on mode stability is below detection limits. When compared to the expected signals in the absence of TM-induced transport, both the average and modulated neutron signals deviate, implying that fast-ion transport occurs in much of phase space. Fast-ion D-α (FIDA) measurements detect reductions in signal at wavelengths that are sensitive to counter-passing ions. Neutral particle analyzer data imply poor confinement of trapped fast ions. Lastly, calculations of the expected fast-ion transport that use measured TM properties successfully reproduce the data.« less
Asprosin, a fasting-induced glucogenic protein hormone

USDA-ARS?s Scientific Manuscript database

Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is t...
Nuclear Engineering Computer Modules, Thermal-Hydraulics, TH-2: Liquid Metal Fast Breeder Reactors.

ERIC Educational Resources Information Center

Reihman, Thomas C.

This learning module is concerned with the temperature field, the heat transfer rates, and the coolant pressure drop in typical liquid metal fast breeder reactor (LMFBR) fuel assemblies. As in all of the modules of this series, emphasis is placed on developing the theory and demonstrating the use with a simplified model. The heart of the module is…
NAS (Host/ARTS) IIIA to VME Modem Interface ATC Interface Hardware Manual

DOT National Transportation Integrated Search

1990-10-01

This document is reference material for personnel using the National Airspace : System (NAS) (HOST or ARTS IIIA) Air Traffic Control (ATC) Interface Subsystem. : It was originally developed to be part of the Data Link Test and Analysis System : (DATA...
Developing Spatial Management Options for the Protection of Vulnerable Marine Ecosystems in the South Pacific Ocean Region.

NASA Astrophysics Data System (ADS)

Rowden, A. A.; Lundquist, C. J.; Clark, M. R.; Anderson, O. F.; Guinotte, J. M.; Baird, S. J.; Roux, M. J.; Wadhwa, S.

2016-02-01

The South Pacific Regional Fisheries Management Organisation (SPRFMO) Convention includes specific provisions to protect vulnerable marine ecosystems (VMEs). The SPRFMO Commission has determined that the interim measures put in place to protect VMEs would be replaced by an improved system of fishable and closed areas. These closures would effectively represent a preliminary spatial management plan, whereby conservation and management measures are implemented that will result in sustainable fisheries and benthic protection. We used the conservation planning tool Zonation to develop spatial management options that balance the protection of VMEs with utilisation of high value areas for fishing. Input data included habitat suitability maps, and uncertainties associated with these model predictions, for eleven VME indicator taxa (4 Scleractinian coral species; 3 other cnidarian groups (Family Stylasteridae, Order Antipatharia, Order Pennatulacea; 2 classes of sponges (Demospongiae, Hexactinellidae), and 2 echninoderm groups (Crinoidea and Brisingida)) at bathyal depths across the entire SPRFMO area (divided into 1 km2 grid cells); New Zealand fishing catch data (for two different time periods and trawl types); naturalness (represented by proxy variable using the number of trawl tows); and a bioregionalisation scheme. Running various scenario models for spatial planning allowed for the cost to fishing to be determined, in terms of the amount of the trawl catch footprint lost if high priority areas for VME indicator taxa are protected. Generally, the cost to fishing was low given the relatively high proportion of suitable habitat for VME indicator taxa protected. The main outcome of the present study is a demonstration of the practical utility of using available data, including modelled data, and the Zonation conservation planning software tool to develop options for the spatial management of the SPRFMO area.
Adaptive Signal Processing Testbed: VME-based DSP board market survey

NASA Astrophysics Data System (ADS)

Ingram, Rick E.

1992-04-01

The Adaptive Signal Processing Testbed (ASPT) is a real-time multiprocessor system utilizing digital signal processor technology on VMEbus based printed circuit boards installed on a Sun workstation. The ASPT has specific requirements, particularly as regards to the signal excision application, with respect to interfacing with current and planned data generation equipment, processing of the data, storage to disk of final and intermediate results, and the development tools for applications development and integration into the overall EW/COM computing environment. A prototype ASPT was implemented using three VME-C-30 boards from Applied Silicon. Experience gained during the prototype development led to the conclusions that interprocessor communications capability is the most significant contributor to overall ASPT performance. In addition, the host involvement should be minimized. Boards using different processors were evaluated with respect to the ASPT system requirements, pricing, and availability. Specific recommendations based on various priorities are made as well as recommendations concerning the integration and interaction of various tools developed during the prototype implementation.
Fast-cycling unit of root turnover in perennial herbaceous plants in a cold temperate ecosystem

NASA Astrophysics Data System (ADS)

Sun, Kai; Luke McCormack, M.; Li, Le; Ma, Zeqing; Guo, Dali

2016-01-01

Roots of perennial plants have both persistent portion and fast-cycling units represented by different levels of branching. In woody species, the distal nonwoody branch orders as a unit are born and die together relatively rapidly (within 1-2 years). However, whether the fast-cycling units also exist in perennial herbs is unknown. We monitored root demography of seven perennial herbs over two years in a cold temperate ecosystem and we classified the largest roots on the root collar or rhizome as basal roots, and associated finer laterals as secondary, tertiary and quaternary roots. Parallel to woody plants in which distal root orders form a fast-cycling module, basal root and its finer laterals also represent a fast-cycling module in herbaceous plants. Within this module, basal roots had a lifespan of 0.5-2 years and represented 62-87% of total root biomass, thus dominating annual root turnover (60%-81% of the total). Moreover, root traits including root length, tissue density, and biomass were useful predictors of root lifespan. We conclude that both herbaceous and woody plants have fast-cycling modular units and future studies identifying the fast-cycling module across plant species should allow better understanding of how root construction and turnover are linked to whole-plant strategies.
A hardware/software environment to support R D in intelligent machines and mobile robotic systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, R.C.

1990-01-01

The Center for Engineering Systems Advanced Research (CESAR) serves as a focal point at the Oak Ridge National Laboratory (ORNL) for basic and applied research in intelligent machines. R D at CESAR addresses issues related to autonomous systems, unstructured (i.e. incompletely known) operational environments, and multiple performing agents. Two mobile robot prototypes (HERMIES-IIB and HERMIES-III) are being used to test new developments in several robot component technologies. This paper briefly introduces the computing environment at CESAR which includes three hypercube concurrent computers (two on-board the mobile robots), a graphics workstation, VAX, and multiple VME-based systems (several on-board the mobile robots).more » The current software environment at CESAR is intended to satisfy several goals, e.g.: code portability, re-usability in different experimental scenarios, modularity, concurrent computer hardware transparent to applications programmer, future support for multiple mobile robots, support human-machine interface modules, and support for integration of software from other, geographically disparate laboratories with different hardware set-ups. 6 refs., 1 fig.« less
Preliminary results on time-resolved ion beam induced luminescence applied to the provenance study of lapis lazuli

NASA Astrophysics Data System (ADS)

Czelusniak, C.; Palla, L.; Massi, M.; Carraresi, L.; Giuntini, L.; Re, A.; Lo Giudice, A.; Pratesi, G.; Mazzinghi, A.; Ruberto, C.; Castelli, L.; Fedi, M. E.; Liccioli, L.; Gueli, A.; Mandò, P. A.; Taccetti, F.

2016-03-01

This work will present preliminary results concerning the use of time-resolved ion beam induced luminescence applied to provenance studies of lapis lazuli. Measurements were performed at the pulsed beam facility at LABEC laboratory in Florence. Lapis lazuli is a semi-precious gemstone, used as ornament since the early civilizations that can be found in few places on Earth. The importance of this work lies in understanding the origin of various samples of lapis lazuli, from which it may be possible to gain insight into trade routes from ancient times. The samples studied in this work originated from Chile, Afghanistan, Tajikistan, Myanmar, and Siberia. The stones were irradiated with 3 MeV protons and the resulting luminescence was detected by a photomultiplier tube, whose output was acquired using a sampling digitizer VME module (CAEN/V1720). Wavelength discrimination was performed at 430 nm utilizing a range of beam currents. The results showed that, by changing the beam current intensity, one can study different features of lapis lazuli, and this may aid in distinguishing lapis lazuli from different provenances.
Architectures for intelligent machines

NASA Technical Reports Server (NTRS)

Saridis, George N.

1991-01-01

The theory of intelligent machines has been recently reformulated to incorporate new architectures that are using neural and Petri nets. The analytic functions of an intelligent machine are implemented by intelligent controls, using entropy as a measure. The resulting hierarchical control structure is based on the principle of increasing precision with decreasing intelligence. Each of the three levels of the intelligent control is using different architectures, in order to satisfy the requirements of the principle: the organization level is moduled after a Boltzmann machine for abstract reasoning, task planning and decision making; the coordination level is composed of a number of Petri net transducers supervised, for command exchange, by a dispatcher, which also serves as an interface to the organization level; the execution level, include the sensory, planning for navigation and control hardware which interacts one-to-one with the appropriate coordinators, while a VME bus provides a channel for database exchange among the several devices. This system is currently implemented on a robotic transporter, designed for space construction at the CIRSSE laboratories at the Rensselaer Polytechnic Institute. The progress of its development is reported.
Exploring the Relationship Between Working Memory, Compressor Speed, and Background Noise Characteristics.

PubMed

Ohlenforst, Barbara; Souza, Pamela E; MacDonald, Ewen N

2016-01-01

Previous work has shown that individuals with lower working memory demonstrate reduced intelligibility for speech processed with fast-acting compression amplification. This relationship has been noted in fluctuating noise, but the extent of noise modulation that must be present to elicit such an effect is unknown. This study expanded on previous study by exploring the effect of background noise modulations in relation to compression speed and working memory ability, using a range of signal to noise ratios. Twenty-six older participants between ages 61 and 90 years were grouped by high or low working memory according to their performance on a reading span test. Speech intelligibility was measured for low-context sentences presented in background noise, where the noise varied in the extent of amplitude modulation. Simulated fast- or slow-acting compression amplification combined with individual frequency-gain shaping was applied to compensate for the individual's hearing loss. Better speech intelligibility scores were observed for participants with high working memory when fast compression was applied than when slow compression was applied. The low working memory group behaved in the opposite way and performed better under slow compression compared with fast compression. There was also a significant effect of the extent of amplitude modulation in the background noise, such that the magnitude of the score difference (fast versus slow compression) depended on the number of talkers in the background noise. The presented signal to noise ratios were not a significant factor on the measured intelligibility performance. In agreement with earlier research, high working memory allowed better speech intelligibility when fast compression was applied in modulated background noise. In the present experiment, that effect was present regardless of the extent of background noise modulation.
Quantitative Comparison of Virtual Monochromatic Images of Dual Energy Computed Tomography Systems: Beam Hardening Artifact Correction and Variance in Computed Tomography Numbers: A Phantom Study.

PubMed

Wu, Rongli; Watanabe, Yoshiyuki; Satoh, Kazuhiko; Liao, Yen-Peng; Takahashi, Hiroto; Tanaka, Hisashi; Tomiyama, Noriyuki

2018-05-21

The aim of this study was to quantitatively compare the reduction in beam hardening artifact (BHA) and variance in computed tomography (CT) numbers of virtual monochromatic energy (VME) images obtained with 3 dual-energy computed tomography (DECT) systems at a given radiation dose. Five different iodine concentrations were scanned using dual-energy and single-energy (120 kVp) modes. The BHA and CT number variance were evaluated. For higher iodine concentrations, 40 and 80 mgI/mL, BHA on VME imaging was significantly decreased when the energy was higher than 50 keV (P = 0.003) and 60 keV (P < 0.001) for GE, higher than 80 keV (P < 0.001) and 70 keV (P = 0.002) for Siemens, and higher than 40 keV (P < 0.001) and 60 keV (P < 0.001) for Toshiba, compared with single-energy CT imaging. Virtual monochromatic energy imaging can decrease BHA and improve CT number accuracy in different dual-energy computed tomography systems, depending on energy levels and iodine concentrations.
Onboard spectral imager data processor

NASA Astrophysics Data System (ADS)

Otten, Leonard J.; Meigs, Andrew D.; Franklin, Abraham J.; Sears, Robert D.; Robison, Mark W.; Rafert, J. Bruce; Fronterhouse, Donald C.; Grotbeck, Ronald L.

1999-10-01

Previous papers have described the concept behind the MightySat II.1 program, the satellite's Fourier Transform imaging spectrometer's optical design, the design for the spectral imaging payload, and its initial qualification testing. This paper discusses the on board data processing designed to reduce the amount of downloaded data by an order of magnitude and provide a demonstration of a smart spaceborne spectral imaging sensor. Two custom components, a spectral imager interface 6U VME card that moves data at over 30 MByte/sec, and four TI C-40 processors mounted to a second 6U VME and daughter card, are used to adapt the sensor to the spacecraft and provide the necessary high speed processing. A system architecture that offers both on board real time image processing and high-speed post data collection analysis of the spectral data has been developed. In addition to the on board processing of the raw data into a usable spectral data volume, one feature extraction technique has been incorporated. This algorithm operates on the basic interferometric data. The algorithm is integrated within the data compression process to search for uploadable feature descriptions.
Investigation on molecular interactions of binary mixtures of isobutanol with 1-alkanols (C1 - C6) at different temperatures. Application of the Peng-Robinson-Stryjek-Vera (PSRV) equation of state (EOS)

NASA Astrophysics Data System (ADS)

Khanlarzadeh, K.; Iloukhani, H.; Soleimani, M.

2017-07-01

Densities were measured for binary mixtures of isobutanol with 1-alkanols, namely: methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol at the temperatures of (288.15, 298.15 and 308.15) K and ambient pressure. Excess molar volumes, VmE , thermal expansion coefficients α, excess thermal expansion coefficients αE, and isothermal coefficients of pressure excess molar enthalpy, (∂HmE / ∂ P) T , x , were derived from the experimental data and the computed results were fitted to the Redlich-Kister equation. The Peng-Robinson-Stryjek-Vera (PRSV) equation of state was applied, in combination with simple mixing rules to predict the excess molar volume. The VmE results were positive for the mixtures of isobutanol with methanol, ethanol, 1-propanol, 1-butanol, and negative for isobutanol with 1-pentanol and 1-hexanol over the whole composition range. The results showed very small deviations from the behavior of ideal solutions in these mixtures and were analyzed to discuss the nature and strength of intermolecular interactions.
Installation and management of the SPS and LEP control system computers

NASA Astrophysics Data System (ADS)

Bland, Alastair

1994-12-01

Control of the CERN SPS and LEP accelerators and service equipment on the two CERN main sites is performed via workstations, file servers, Process Control Assemblies (PCAs) and Device Stub Controllers (DSCs). This paper describes the methods and tools that have been developed to manage the file servers, PCAs and DSCs since the LEP startup in 1989. There are five operational DECstation 5000s used as file servers and boot servers for the PCAs and DSCs. The PCAs consist of 90 SCO Xenix 386 PCs, 40 LynxOS 486 PCs and more than 40 older NORD 100s. The DSCs consist of 90 OS-968030 VME crates and 10 LynxOS 68030 VME crates. In addition there are over 100 development systems. The controls group is responsible for installing the computers, starting all the user processes and ensuring that the computers and the processes run correctly. The operators in the SPS/LEP control room and the Services control room have a Motif-based X window program which gives them, in real time, the state of all the computers and allows them to solve problems or reboot them.
Fasting is a physiological stimulus of vagus-mediated enhancement of nociception in the female rat.

PubMed

Khasar, S G; Reichling, D B; Green, P G; Isenberg, W M; Levine, J D

2003-01-01

The vagus nerve modulates nociception by a mechanism dependent upon gonadal hormones and the adrenal medulla. In the present study we tested the hypothesis that this modulation is dynamically controlled by physiological stimulation of structures innervated by the subdiaphragmatic vagus. Specifically, food deprivation (fasting) was employed to increase activity in the subdiaphragmatic vagus, and the experiments were performed mainly in female rats because our previous observations suggested that baseline activity in the pathway is lower in females than in males. Consistent with the hypothesis, after a 48-h fast, female rats exhibited increased nociceptive behavior in the formalin test. In contrast, fasting had no effect on formalin-evoked nociceptive behavior in male rats. The fasting-induced effect on nociception appears to be mediated by the vagus nerve since it is prevented by subdiaphragmatic vagotomy. Also similar to the previously characterized vagus-mediated modulation, the effect of fasting in the female is blocked by gonadectomy or adrenal medullectomy, and hormone replacement with 17beta-estradiol in gonadectomized female rats restored the effect of fasting. Decreased glucose metabolism apparently does not play a significant role in the effect of fasting on nociception, since the effect was unchanged when 5% glucose was provided in the drinking water throughout the fasting period. On the other hand, increasing the bulk content of the stomach (without providing nutrients) by infusion of petrolatum significantly attenuated the effect of fasting during the interphase period of the formalin response, suggesting that decreased gut distention, and possibly motility, are important in fasting-induced enhancement of nociception. These results indicate that fasting is a physiological activator of the vagus-mediated pain modulation pathway. This suggests the possibility that, especially in females, natural periodic changes in gut distention and motility may control an ongoing vagus-mediated adjustment in the organism's nociceptive sensitivity.
Signal-Conditioning Amplifier Recorders

NASA Technical Reports Server (NTRS)

Medelius, Pedro J.; Taylor, John

2003-01-01

Signal-conditioning amplifier recorders (SCAmpRs) have been proposed as a means of simplifying and upgrading the Kennedy Space Center (KSC) Ground Measurement System (GMS), which is a versatile data-acquisition system that gathers and records a variety of measurement data before and during the launch of a space shuttle. In the present version of the GMS system, signal conditioning amplifiers digitize and transmit data to a VME chassis that multiplexes up to 416 channels. The data is transmitted via a high-speed data bus to a second VME chassis where it is available for snapshots. The data is passed from the second VME chassis to a high-speed data recorder. This process is duplicated for installations at two launch pads and the Vehicle Assembly Building (VAB). Since any failure of equipment in the data path results in loss of data, much of the system is redundant. The architecture of the existing GMS limits expansion or any modification to the system to meet changing requirements because of the cost and time required. A SCAmpR-based system is much more flexible. The basis of the simplification, flexibility, and reliability is the shifting of the recording function to the individual amplifier channels. Each SCAmpR is a self-contained single channel data acquisition system, which in its current implementation, has a data storage capacity of up to 30 minutes when operating at the fastest data sampling rates. The SCAmpR channels are self-configuring and self-calibrating. Multiple SCAmpR channels are ganged on printed circuit boards and mounted in a chassis that provides power, a network hub, and Inter-Range Instrument Group (IRIG) time signals. The SCAmpR channels share nothing except physical mounting on a circuit board. All circuitry is electrically separate for each channel. All that is necessary to complete the data acquisition system is a single master computer tied to the SCAmpR channels by standard network equipment. The size of the data acquisition system dictates the requirements for the specific network equipment.
Fast charging nickel-metal hydride traction batteries

NASA Astrophysics Data System (ADS)

Yang, Xiao Guang; Liaw, Bor Yann

This paper describes the fast charge ability, or "fast rechargeability", of nominal 85 Ah Ni-MH modules under various fast charge conditions, including constant current (CC); typically 1-3C, and constant power (CP) regimes. Our tests revealed that there is no apparent difference between CC and CP fast charge regimes with respect to charge efficiency and time. Following the USABC Electric Vehicle Battery Test Procedures Manual (Revision 2, 1996), we demonstrated that we were able to return 40% state of charge (SOC) from 60% depth of discharge (DOD) to 20% DOD within 15 min. Most importantly, we found that the internal pressure of the cell is the most critical parameter in the control of the fast charge process and the safe operation of the modules.

Neutronic calculation of fast reactors by the EUCLID/V1 integrated code

NASA Astrophysics Data System (ADS)

Koltashev, D. A.; Stakhanova, A. A.

2017-01-01

This article considers neutronic calculation of a fast-neutron lead-cooled reactor BREST-OD-300 by the EUCLID/V1 integrated code. The main goal of development and application of integrated codes is a nuclear power plant safety justification. EUCLID/V1 is integrated code designed for coupled neutronics, thermomechanical and thermohydraulic fast reactor calculations under normal and abnormal operating conditions. EUCLID/V1 code is being developed in the Nuclear Safety Institute of the Russian Academy of Sciences. The integrated code has a modular structure and consists of three main modules: thermohydraulic module HYDRA-IBRAE/LM/V1, thermomechanical module BERKUT and neutronic module DN3D. In addition, the integrated code includes databases with fuel, coolant and structural materials properties. Neutronic module DN3D provides full-scale simulation of neutronic processes in fast reactors. Heat sources distribution, control rods movement, reactivity level changes and other processes can be simulated. Neutron transport equation in multigroup diffusion approximation is solved. This paper contains some calculations implemented as a part of EUCLID/V1 code validation. A fast-neutron lead-cooled reactor BREST-OD-300 transient simulation (fuel assembly floating, decompression of passive feedback system channel) and cross-validation with MCU-FR code results are presented in this paper. The calculations demonstrate EUCLID/V1 code application for BREST-OD-300 simulating and safety justification.
High frequency modulation and injection locking of terahertz quantum cascade lasers

NASA Astrophysics Data System (ADS)

Gu, L.; Wan, W. J.; Zhu, Y. H.; Fu, Z. L.; Li, H.; Cao, J. C.

2017-06-01

Due to intersubband transitions, the quantum cascade laser (QCL) is free of relaxations and able to work under fast modulations. In this work, the authors investigate the fast modulation properties of a continuous wave (cw) terahertz QCL emitting around 3 THz (˜100 μm). Both simulation and experimental results show that the 3 dB modulation bandwidth for the device can reach 11.5 GHz and the modulation response curve is relatively flat upto ˜16 GHz. The radio frequency (RF) injection measurements verify that around the laser threshold the inter-mode beat note interacts strongly with the RF signal and the laser can be modulated at the round trip frequency of 15.5 GHz.
A Versatile Image Processor For Digital Diagnostic Imaging And Its Application In Computed Radiography

NASA Astrophysics Data System (ADS)

Blume, H.; Alexandru, R.; Applegate, R.; Giordano, T.; Kamiya, K.; Kresina, R.

1986-06-01

In a digital diagnostic imaging department, the majority of operations for handling and processing of images can be grouped into a small set of basic operations, such as image data buffering and storage, image processing and analysis, image display, image data transmission and image data compression. These operations occur in almost all nodes of the diagnostic imaging communications network of the department. An image processor architecture was developed in which each of these functions has been mapped into hardware and software modules. The modular approach has advantages in terms of economics, service, expandability and upgradeability. The architectural design is based on the principles of hierarchical functionality, distributed and parallel processing and aims at real time response. Parallel processing and real time response is facilitated in part by a dual bus system: a VME control bus and a high speed image data bus, consisting of 8 independent parallel 16-bit busses, capable of handling combined up to 144 MBytes/sec. The presented image processor is versatile enough to meet the video rate processing needs of digital subtraction angiography, the large pixel matrix processing requirements of static projection radiography, or the broad range of manipulation and display needs of a multi-modality diagnostic work station. Several hardware modules are described in detail. For illustrating the capabilities of the image processor, processed 2000 x 2000 pixel computed radiographs are shown and estimated computation times for executing the processing opera-tions are presented.
Hybrid spread spectrum radio system

DOEpatents

Smith, Stephen F.; Dress, William B.

2010-02-02

Systems and methods are described for hybrid spread spectrum radio systems. A method includes modulating a signal by utilizing a subset of bits from a pseudo-random code generator to control an amplification circuit that provides a gain to the signal. Another method includes: modulating a signal by utilizing a subset of bits from a pseudo-random code generator to control a fast hopping frequency synthesizer; and fast frequency hopping the signal with the fast hopping frequency synthesizer, wherein multiple frequency hops occur within a single data-bit time.
Learning Environments and Inquiry Behaviors in Science Inquiry Learning: How Their Interplay Affects the Development of Conceptual Understanding in Physics

ERIC Educational Resources Information Center

Bumbacher, Engin; Salehi, Shima; Wierzchula, Miriam; Blikstein, Paulo

2015-01-01

Studies comparing virtual and physical manipulative environments (VME and PME) in inquiry-based science learning have mostly focused on students' learning outcomes but not on the actual processes they engage in during the learning activities. In this paper, we examined experimentation strategies in an inquiry activity and their relation to…
Renewal of the Control System and Reliable Long Term Operation of the LHD Cryogenic System

NASA Astrophysics Data System (ADS)

Mito, T.; Iwamoto, A.; Oba, K.; Takami, S.; Moriuchi, S.; Imagawa, S.; Takahata, K.; Yamada, S.; Yanagi, N.; Hamaguchi, S.; Kishida, F.; Nakashima, T.

The Large Helical Device (LHD) is a heliotron-type fusion plasma experimental machine which consists of a fully superconducting magnet system cooled by a helium refrigerator having a total equivalent cooling capacity of 9.2 kW@4.4 K. Seventeenplasma experimental campaigns have been performed successfully since1997 with high reliability of 99%. However, sixteen years have passed from the beginning of the system operation. Improvements are being implementedto prevent serious failures and to pursue further reliability.The LHD cryogenic control system was designed and developed as an open system utilizing latest control equipment of VME controllers and UNIX workstations at the construction time. Howeverthe generation change of control equipment has been advanced. Down-sizing of control deviceshas beenplanned from VME controllers to compact PCI controllers in order to simplify the system configuration and to improve the system reliability. The new system is composed of compact PCI controller and remote I/O connected with EtherNet/IP. Making the system redundant becomes possible by doubling CPU, LAN, and remote I/O respectively. The smooth renewal of the LHD cryogenic controlsystem and the further improvement of the cryogenic system reliability are reported.
High-frequency gamma oscillations coexist with low-frequency gamma oscillations in the rat visual cortex in vitro.

PubMed

Oke, Olaleke O; Magony, Andor; Anver, Himashi; Ward, Peter D; Jiruska, Premysl; Jefferys, John G R; Vreugdenhil, Martin

2010-04-01

Synchronization of neuronal activity in the visual cortex at low (30-70 Hz) and high gamma band frequencies (> 70 Hz) has been associated with distinct visual processes, but mechanisms underlying high-frequency gamma oscillations remain unknown. In rat visual cortex slices, kainate and carbachol induce high-frequency gamma oscillations (fast-gamma; peak frequency approximately 80 Hz at 37 degrees C) that can coexist with low-frequency gamma oscillations (slow-gamma; peak frequency approximately 50 Hz at 37 degrees C) in the same column. Current-source density analysis showed that fast-gamma was associated with rhythmic current sink-source sequences in layer III and slow-gamma with rhythmic current sink-source sequences in layer V. Fast-gamma and slow-gamma were not phase-locked. Slow-gamma power fluctuations were unrelated to fast-gamma power fluctuations, but were modulated by the phase of theta (3-8 Hz) oscillations generated in the deep layers. Fast-gamma was spatially less coherent than slow-gamma. Fast-gamma and slow-gamma were dependent on gamma-aminobutyric acid (GABA)(A) receptors, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and gap-junctions, their frequencies were reduced by thiopental and were weakly dependent on cycle amplitude. Fast-gamma and slow-gamma power were differentially modulated by thiopental and adenosine A(1) receptor blockade, and their frequencies were differentially modulated by N-methyl-D-aspartate (NMDA) receptors, GluK1 subunit-containing receptors and persistent sodium currents. Our data indicate that fast-gamma and slow-gamma both depend on and are paced by recurrent inhibition, but have distinct pharmacological modulation profiles. The independent co-existence of fast-gamma and slow-gamma allows parallel processing of distinct aspects of vision and visual perception. The visual cortex slice provides a novel in vitro model to study cortical high-frequency gamma oscillations.
The AD and ELENA orbit, trajectory and intensity measurement systems

NASA Astrophysics Data System (ADS)

Marco-Hernández, R.; Alves, D.; Angoletta, M. E.; Marqversen, O.; Molendijk, J.; Oponowicz, E.; Ruffieux, R.; Sánchez-Quesada, J.; SØby, L.

2017-07-01

This paper describes the new Antiproton Decelerator (AD) orbit measurement system and the Extra Low ENergy Antiproton ring (ELENA) orbit, trajectory and intensity measurement system. The AD machine at European Organization for Nuclear Research (CERN) is presently being used to decelerate antiprotons from 3.57 GeV/c to 100 MeV/c for matter vs anti-matter comparative studies. The ELENA machine, presently under commissioning, has been designed to provide an extra deceleration stage down to 13.7 MeV/c. The AD orbit system is based on 32 horizontal and 27 vertical electrostatic Beam Position Monitor (BPM) fitted with existing low noise front-end amplifiers while the ELENA system consists of 24 \\gls{BPM}s equipped with new low-noise head amplifiers. In both systems the front-end amplifiers generate a difference (delta) and a sum (sigma) signal which are sent to the digital acquisition system, placed tens of meters away from the AD or ELENA rings, where they are digitized and further processed. The beam position is calculated by dividing the difference signal by the sum signal either using directly the raw digitized data for measuring the turn-by-turn trajectory in the ELENA system or after down-mixing the signals to baseband for the orbit measurement in both machines. The digitized sigma signal will be used in the ELENA system to calculate the bunched beam intensity and the Schottky parameters with coasting beam after passing through different signal processing chain. The digital acquisition arrangement for both systems is based on the same hardware, also used in the ELENA Low Level Radio Frequency (LLRF) system, which follows the VME Switched Serial (VXS) enhancement of the Versa Module Eurocard 64x extension (VME64x) standard and includes VITA 57 standard Field Programmable Gate Array Mezzanine Card (FMC). The digital acquisition Field Programmable Gate Array (FPGA) and Digital Signal Processor (DSP) firmware shares many common functionalities with the LLRF system but has been tailored for this measurement application in particular. Specific control and acquisition software has been developed for these systems. Both systems are installed in AD and ELENA. The AD orbit system currently measures the orbit in AD while the ELENA system is being used in the commissioning of the ELENA ring.
H4DAQ: a modern and versatile data-acquisition package for calorimeter prototypes test-beams

NASA Astrophysics Data System (ADS)

Marini, A. C.

2018-02-01

The upgrade of the particle detectors for the HL-LHC or for future colliders requires an extensive program of tests to qualify different detector prototypes with dedicated test beams. A common data-acquisition system, H4DAQ, was developed for the H4 test beam line at the North Area of the CERN SPS in 2014 and it has since been adopted in various applications for the CMS experiment and AIDA project. Several calorimeter prototypes and precision timing detectors have used our system from 2014 to 2017. H4DAQ has proven to be a versatile application and has been ported to many other beam test environments. H4DAQ is fast, simple, modular and can be configured to support various kinds of setup. The functionalities of the DAQ core software are split into three configurable finite state machines: data readout, run control, and event builder. The distribution of information and data between the various computers is performed using ZEROMQ (0MQ) sockets. Plugins are available to read different types of hardware, including VME crates with many types of boards, PADE boards, custom front-end boards and beam instrumentation devices. The raw data are saved as ROOT files, using the CERN C++ ROOT libraries. A Graphical User Interface, based on the python gtk libraries, is used to operate the H4DAQ and an integrated data quality monitoring (DQM), written in C++, allows for fast processing of the events for quick feedback to the user. As the 0MQ libraries are also available for the National Instruments LabVIEW program, this environment can easily be integrated within H4DAQ applications.
Modulating complex beams in amplitude and phase using fast tilt-micromirror arrays and phase masks.

PubMed

Roth, Matthias; Heber, Jörg; Janschek, Klaus

2018-06-15

The Letter proposes a system for the spatial modulation of light in amplitude and phase at kilohertz frame rates and high spatial resolution. The focus is fast spatial light modulators (SLMs) consisting of continuously tiltable micromirrors. We investigate the utilization of such SLMs in combination with a static phase mask in a 4f setup. The phase mask enables the complex beam modulation in a linear optical arrangement. Furthermore, adding so-called phase steps to the phase mask increases both the number of image pixels at constant SLM resolution and the optical efficiency. We illustrate our concept based on numerical simulations.
Parallel image reconstruction for 3D positron emission tomography from incomplete 2D projection data

NASA Astrophysics Data System (ADS)

Guerrero, Thomas M.; Ricci, Anthony R.; Dahlbom, Magnus; Cherry, Simon R.; Hoffman, Edward T.

1993-07-01

The problem of excessive computational time in 3D Positron Emission Tomography (3D PET) reconstruction is defined, and we present an approach for solving this problem through the construction of an inexpensive parallel processing system and the adoption of the FAVOR algorithm. Currently, the 3D reconstruction of the 610 images of a total body procedure would require 80 hours and the 3D reconstruction of the 620 images of a dynamic study would require 110 hours. An inexpensive parallel processing system for 3D PET reconstruction is constructed from the integration of board level products from multiple vendors. The system achieves its computational performance through the use of 6U VME four i860 processor boards, the processor boards from five manufacturers are discussed from our perspective. The new 3D PET reconstruction algorithm FAVOR, FAst VOlume Reconstructor, that promises a substantial speed improvement is adopted. Preliminary results from parallelizing FAVOR are utilized in formulating architectural improvements for this problem. In summary, we are addressing the problem of excessive computational time in 3D PET image reconstruction, through the construction of an inexpensive parallel processing system and the parallelization of a 3D reconstruction algorithm that uses the incomplete data set that is produced by current PET systems.
Performance of compact fast pyrolysis reactor with Auger-type modules for the continuous liquid biofuel production

NASA Astrophysics Data System (ADS)

Nishimura, Shun; Ebitani, Kohki

2018-01-01

Development of a compact fast pyrolysis reactor constructed using Auger-type technology to afford liquid biofuel with high yield has been an interesting concept in support of local production for local consumption. To establish a widely useable module package, details of the performance of the developing compact module reactor were investigated. This study surveyed the properties of as-produced pyrolysis oil as a function of operation time, and clarified the recent performance of the developing compact fast pyrolysis reactor. Results show that after condensation in the scrubber collector, e.g. approx. 10 h for a 25 kg/h feedstock rate, static performance of pyrolysis oil with approximately 20 MJ/kg (4.8 kcal/g) calorific values were constantly obtained after an additional 14 h. The feeding speed of cedar chips strongly influenced the time for oil condensation process: i.e. 1.6 times higher feeding speed decreased the condensation period by half (approx. 5 h in the case of 40 kg/h). Increasing the reactor throughput capacity is an important goal for the next stage in the development of a compact fast pyrolysis reactor with Auger-type modules.
Amplitude Control of Solid-State Modulators for Precision Fast Kicker Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J A; Anaya, R M; Caporaso, G C

2002-11-15

A solid-state modulator with very fast rise and fall times, pulse width agility, and multi-pulse burst and intra-pulse amplitude adjustment capability for use with high speed electron beam kickers has been designed and tested at LLNL. The modulator uses multiple solid-state modules stacked in an inductive-adder configuration. Amplitude adjustment is provided by controlling individual modules in the adder, and is used to compensate for transverse e-beam motion as well as the dynamic response and beam-induced steering effects associated with the kicker structure. A control algorithm calculates a voltage based on measured e-beam displacement and adjusts the modulator to regulate beammore » centroid position. This paper presents design details of amplitude control along with measured performance data from kicker operation on the ETA-II accelerator at LLNL.« less
Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.

PubMed

Gemmink, Anne; Bosma, Madeleen; Kuijpers, Helma J H; Hoeks, Joris; Schaart, Gert; van Zandvoort, Marc A M J; Schrauwen, Patrick; Hesselink, Matthijs K C

2016-05-01

In contrast to insulin-resistant individuals, insulin-sensitive athletes possess high intramyocellular lipid content (IMCL), good mitochondrial function and high perilipin 5 (PLIN5) levels, suggesting a role for PLIN5 in benign IMCL storage. We hypothesised a role for PLIN5 in modulating fasting-mediated insulin resistance. Twelve men were fasted for 60 h, before and after which muscle biopsies were taken and stained for lipid droplets (LDs), PLIN5 and laminin. Confocal microscopy images were analysed for LD size, number, PLIN5 association and subcellular distribution. Fasting elevated IMCL content 2.8-fold and reduced insulin sensitivity (by 55%). Individuals with the most prominent increase in IMCL showed the least reduction in insulin sensitivity (r = 0.657; p = 0.028) and mitochondrial function (r = 0.896; p = 0.006). During fasting, PLIN5 gene expression or PLIN5 protein content in muscle homogenates was unaffected, microscopy analyses revealed that the fraction of PLIN5 associated with LDs (PLIN5+) increased significantly (+26%) upon fasting, suggesting PLIN5 redistribution. The significant increase in LD number (+23%) and size (+23%) upon fasting was entirely accounted for by PLIN5+ LDs, not by LDs devoid of PLIN5. Also the association between IMCL storage capacity and insulin resistance and mitochondrial dysfunction was only apparent for PLIN5+ LDs. Fasting results in subcellular redistribution of PLIN5 and promotes the capacity to store excess fat in larger and more numerous PLIN5-decorated LDs. This associates with blunting of fasting-induced insulin resistance and mitochondrial dysfunction, suggesting a role for PLIN5 in the modulation of fasting-mediated lipotoxicity. trialregister.nl NTR 2042.
JPRS Report Science & Technology Japan Space Artificial Intelligence/Robotics/Automation Symposium.

DTIC Science & Technology

1989-12-28

Kazuya Kaku, et al. ] 28 Spacecraft Automatic Monitoring System [Kazuya Kaku, et al. ] 36 Autonomous Space Robot, Related Computer ...type space vehicle Space station , orbital sup - lport systems Transport systems Ground Systems 1 et»*:«..,..... ri,(rn™ Communciations ...axis torque sensor. Motorola’s VME-10 is used as the computer . 5. Experimental Results To investigate the state of separation between the external
Performance of the EUCAST Disk Diffusion Method, the CLSI Agar Screen Method, and the Vitek 2 Automated Antimicrobial Susceptibility Testing System for Detection of Clinical Isolates of Enterococci with Low- and Medium-Level VanB-Type Vancomycin Resistance: a Multicenter Study

PubMed Central

Giske, Christian G.; Haldorsen, Bjørg; Matuschek, Erika; Schønning, Kristian; Leegaard, Truls M.; Kahlmeter, Gunnar

2014-01-01

Different antimicrobial susceptibility testing methods to detect low-level vancomycin resistance in enterococci were evaluated in a Scandinavian multicenter study (n = 28). A phenotypically and genotypically well-characterized diverse collection of Enterococcus faecalis (n = 12) and Enterococcus faecium (n = 18) strains with and without nonsusceptibility to vancomycin was examined blindly in Danish (n = 5), Norwegian (n = 13), and Swedish (n = 10) laboratories using the EUCAST disk diffusion method (n = 28) and the CLSI agar screen (n = 18) or the Vitek 2 system (bioMérieux) (n = 5). The EUCAST disk diffusion method (very major error [VME] rate, 7.0%; sensitivity, 0.93; major error [ME] rate, 2.4%; specificity, 0.98) and CLSI agar screen (VME rate, 6.6%; sensitivity, 0.93; ME rate, 5.6%; specificity, 0.94) performed significantly better (P = 0.02) than the Vitek 2 system (VME rate, 13%; sensitivity, 0.87; ME rate, 0%; specificity, 1). The performance of the EUCAST disk diffusion method was challenged by differences in vancomycin inhibition zone sizes as well as the experience of the personnel in interpreting fuzzy zone edges as an indication of vancomycin resistance. Laboratories using Oxoid agar (P < 0.0001) or Merck Mueller-Hinton (MH) agar (P = 0.027) for the disk diffusion assay performed significantly better than did laboratories using BBL MH II medium. Laboratories using Difco brain heart infusion (BHI) agar for the CLSI agar screen performed significantly better (P = 0.017) than did those using Oxoid BHI agar. In conclusion, both the EUCAST disk diffusion and CLSI agar screening methods performed acceptably (sensitivity, 0.93; specificity, 0.94 to 0.98) in the detection of VanB-type vancomycin-resistant enterococci with low-level resistance. Importantly, use of the CLSI agar screen requires careful monitoring of the vancomycin concentration in the plates. Moreover, disk diffusion methodology requires that personnel be trained in interpreting zone edges. PMID:24599985
The Functional Arm Scale for Throwers (FAST)-Part II: Reliability and Validity of an Upper Extremity Region-Specific and Population-Specific Patient-Reported Outcome Scale for Throwing Athletes.

PubMed

Huxel Bliven, Kellie C; Snyder Valier, Alison R; Bay, R Curtis; Sauers, Eric L

2017-04-01

The Functional Arm Scale for Throwers (FAST) is an upper extremity (UE) region-specific and population-specific patient-reported outcome (PRO) scale developed to measure health-related quality of life in throwers with UE injuries. Stages I and II, described in a companion paper, of FAST development produced a 22-item scale and a 9-item pitcher module. Stage III of scale development, establishing reliability and validity of the FAST, is reported herein. To describe stage III of scale development: reliability and validity of the FAST. Cohort study (diagnosis); Level of evidence, 2. Data from throwing athletes collected over 5 studies were pooled to assess reliability and validity of the FAST. Reliability was estimated using FAST scores from 162 throwing athletes who were injured (n = 23) and uninjured (n = 139). Concurrent validity was estimated using FAST scores and Disabilities of the Arm, Shoulder, and Hand (DASH) and Kerlan-Jobe Orthopaedic Clinic (KJOC) scores from 106 healthy, uninjured throwing athletes. Known-groups validity was estimated using FAST scores from 557 throwing athletes who were injured (n = 142) and uninjured (n = 415). Reliability and validity were assessed using intraclass correlation coefficients (ICCs), and measurement error was assessed using standard error of measurement (SEM) and minimum detectable change (MDC). Receiver operating characteristic curves and sensitivity/specificity values were estimated for known-groups validity. Data from a separate group (n = 18) of postsurgical and nonoperative/conservative rehabilitation patients were analyzed to report responsiveness of the FAST. The FAST total, subscales, and pitcher module scores demonstrated excellent test-retest reliability (ICC, 0.91-0.98). The SEM 95 and MDC 95 for the FAST total score were 3.8 and 10.5 points, respectively. The SEM 95 and MDC 95 for the pitcher module score were 5.7 and 15.7 points, respectively. The FAST scores showed acceptable correlation with DASH (ICC, 0.49-0.82) and KJOC (ICC, 0.62-0.81) scores. The FAST total score classified 85.1% of players into the correct injury group. For predicting UE injury status, a FAST total cutoff score of 10.0 out of 100.0 was 91% sensitive and 75% specific, and a pitcher module score of 10.0 out of 100.0 was 87% sensitive and 78% specific. The FAST total score demonstrated responsiveness on several indices between intake and discharge time points. The FAST is a reliable, valid, and responsive UE region-specific and population-specific PRO scale for measuring patient-reported health care outcomes in throwing athletes with injury.
The Functional Arm Scale for Throwers (FAST)—Part II: Reliability and Validity of an Upper Extremity Region-Specific and Population-Specific Patient-Reported Outcome Scale for Throwing Athletes

PubMed Central

Huxel Bliven, Kellie C.; Snyder Valier, Alison R.; Bay, R. Curtis; Sauers, Eric L.

2017-01-01

Background: The Functional Arm Scale for Throwers (FAST) is an upper extremity (UE) region-specific and population-specific patient-reported outcome (PRO) scale developed to measure health-related quality of life in throwers with UE injuries. Stages I and II, described in a companion paper, of FAST development produced a 22-item scale and a 9-item pitcher module. Stage III of scale development, establishing reliability and validity of the FAST, is reported herein. Purpose: To describe stage III of scale development: reliability and validity of the FAST. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Data from throwing athletes collected over 5 studies were pooled to assess reliability and validity of the FAST. Reliability was estimated using FAST scores from 162 throwing athletes who were injured (n = 23) and uninjured (n = 139). Concurrent validity was estimated using FAST scores and Disabilities of the Arm, Shoulder, and Hand (DASH) and Kerlan-Jobe Orthopaedic Clinic (KJOC) scores from 106 healthy, uninjured throwing athletes. Known-groups validity was estimated using FAST scores from 557 throwing athletes who were injured (n = 142) and uninjured (n = 415). Reliability and validity were assessed using intraclass correlation coefficients (ICCs), and measurement error was assessed using standard error of measurement (SEM) and minimum detectable change (MDC). Receiver operating characteristic curves and sensitivity/specificity values were estimated for known-groups validity. Data from a separate group (n = 18) of postsurgical and nonoperative/conservative rehabilitation patients were analyzed to report responsiveness of the FAST. Results: The FAST total, subscales, and pitcher module scores demonstrated excellent test-retest reliability (ICC, 0.91-0.98). The SEM95 and MDC95 for the FAST total score were 3.8 and 10.5 points, respectively. The SEM95 and MDC95 for the pitcher module score were 5.7 and 15.7 points, respectively. The FAST scores showed acceptable correlation with DASH (ICC, 0.49-0.82) and KJOC (ICC, 0.62-0.81) scores. The FAST total score classified 85.1% of players into the correct injury group. For predicting UE injury status, a FAST total cutoff score of 10.0 out of 100.0 was 91% sensitive and 75% specific, and a pitcher module score of 10.0 out of 100.0 was 87% sensitive and 78% specific. The FAST total score demonstrated responsiveness on several indices between intake and discharge time points. Conclusion: The FAST is a reliable, valid, and responsive UE region-specific and population-specific PRO scale for measuring patient-reported health care outcomes in throwing athletes with injury. PMID:28451614
Argonne's SpEC Module

ScienceCinema

Harper, Jason

2018-03-02

Jason Harper, an electrical engineer in Argonne National Laboratory's EV-Smart Grid Interoperability Center, discusses his SpEC Module invention that will enable fast charging of electric vehicles in under 15 minutes. The module has been licensed to BTCPower.
Patterning of OPV modules by ultra-fast laser

NASA Astrophysics Data System (ADS)

Kubiš, Peter; Lucera, Luca; Guo, Fei; Spyropolous, George; Voigt, Monika M.; Brabec, Christoph J.

2014-10-01

A novel production process combining slot-die coating, transparent flexible IMI (ITO-Metal-ITO) electrodes and ultra-fast laser ablation can be used for the realization of P3HT:PCBM based thin film flexible OPV modules. The fast and precise laser ablation allows an overall efficiency over 3 % and a device geometric fill factor (GFF) over 95 %. Three functional layers can be ablated using the same wavelength only with varying the laser fluence and overlap. Different OPV device architectures with multilayers utilizing various materials are challenging for ablation but can be structured by using a systematical approach.

A sun-tracking environmental chamber for the outdoor quantification of CPV modules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faiman, David, E-mail: faiman@bgu.ac.il; Melnichak, Vladimir, E-mail: faiman@bgu.ac.il; Bokobza, Dov, E-mail: faiman@bgu.ac.il

2014-09-26

The paper describes a sun-tracking environmental chamber and its associated fast electronics, devised for the accurate outdoor characterization of CPV cells, receivers, mono-modules, and modules. Some typical measurement results are presented.
Controllable optical modulation of blue/green up-conversion fluorescence from Tm3+ (Er3+) single-doped glass ceramics upon two-step excitation of two-wavelengths

PubMed Central

Chen, Zhi; Kang, Shiliang; Zhang, Hang; Wang, Ting; Lv, Shichao; Chen, Qiuqun; Dong, Guoping; Qiu, Jianrong

2017-01-01

Optical modulation is a crucial operation in photonics for network data processing with the aim to overcome information bottleneck in terms of speed, energy consumption, dispersion and cross-talking from conventional electronic interconnection approach. However, due to the weak interactions between photons, a facile physical approach is required to efficiently manipulate photon-photon interactions. Herein, we demonstrate that transparent glass ceramics containing LaF3: Tm3+ (Er3+) nanocrystals can enable fast-slow optical modulation of blue/green up-conversion fluorescence upon two-step excitation of two-wavelengths at telecom windows (0.8–1.8 μm). We show an optical modulation of more than 1500% (800%) of the green (blue) up-conversion fluorescence intensity, and fast response of 280 μs (367 μs) as well as slow response of 5.82 ms (618 μs) in the green (blue) up-conversion fluorescence signal, respectively. The success of manipulating laser at telecom windows for fast-slow optical modulation from rear-earth single-doped glass ceramics may find application in all-optical fiber telecommunication areas. PMID:28368041
High Voltage, Fast-Switching Module for Active Control of Magnetic Fields and Edge Plasma Currents

NASA Astrophysics Data System (ADS)

Ziemba, Timothy; Miller, Kenneth; Prager, James; Slobodov, Ilia

2016-10-01

Fast, reliable, real-time control of plasma is critical to the success of magnetic fusion science. High voltage and current supplies are needed to mitigate instabilities in all experiments as well as disruption events in large scale tokamaks for steady-state operation. Silicon carbide (SiC) MOSFETs offer many advantages over IGBTs including lower drive energy requirements, lower conduction and switching losses, and higher switching frequency capabilities; however, these devices are limited to 1.2-1.7 kV devices. As fusion enters the long-pulse and burning plasma eras, efficiency of power switching will be important. Eagle Harbor Technologies (EHT), Inc. developing a high voltage SiC MOSFET module that operates at 10 kV. This switch module utilizes EHT gate drive technology, which has demonstrated the ability to increase SiC MOSFET switching efficiency. The module will allow more rapid development of high voltage switching power supplies at lower cost necessary for the next generation of fast plasma feedback and control. EHT is partnering with the High Beta Tokamak group at Columbia to develop detailed high voltage module specifications, to ensure that the final product meets the needs of the fusion science community.
A fast method for optical simulation of flood maps of light-sharing detector modules.

PubMed

Shi, Han; Du, Dong; Xu, JianFeng; Moses, William W; Peng, Qiyu

2015-12-01

Optical simulation of the detector module level is highly desired for Position Emission Tomography (PET) system design. Commonly used simulation toolkits such as GATE are not efficient in the optical simulation of detector modules with complicated light-sharing configurations, where a vast amount of photons need to be tracked. We present a fast approach based on a simplified specular reflectance model and a structured light-tracking algorithm to speed up the photon tracking in detector modules constructed with polished finish and specular reflector materials. We simulated conventional block detector designs with different slotted light guide patterns using the new approach and compared the outcomes with those from GATE simulations. While the two approaches generated comparable flood maps, the new approach was more than 200-600 times faster. The new approach has also been validated by constructing a prototype detector and comparing the simulated flood map with the experimental flood map. The experimental flood map has nearly uniformly distributed spots similar to those in the simulated flood map. In conclusion, the new approach provides a fast and reliable simulation tool for assisting in the development of light-sharing-based detector modules with a polished surface finish and using specular reflector materials.
Verification of the New FAST v8 Capabilities for the Modeling of Fixed-Bottom Offshore Wind Turbines: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barahona, B.; Jonkman, J.; Damiani, R.

2014-12-01

Coupled dynamic analysis has an important role in the design of offshore wind turbines because the systems are subject to complex operating conditions from the combined action of waves and wind. The aero-hydro-servo-elastic tool FAST v8 is framed in a novel modularization scheme that facilitates such analysis. Here, we present the verification of new capabilities of FAST v8 to model fixed-bottom offshore wind turbines. We analyze a series of load cases with both wind and wave loads and compare the results against those from the previous international code comparison projects-the International Energy Agency (IEA) Wind Task 23 Subtask 2 Offshoremore » Code Comparison Collaboration (OC3) and the IEA Wind Task 30 OC3 Continued (OC4) projects. The verification is performed using the NREL 5-MW reference turbine supported by monopile, tripod, and jacket substructures. The substructure structural-dynamics models are built within the new SubDyn module of FAST v8, which uses a linear finite-element beam model with Craig-Bampton dynamic system reduction. This allows the modal properties of the substructure to be synthesized and coupled to hydrodynamic loads and tower dynamics. The hydrodynamic loads are calculated using a new strip theory approach for multimember substructures in the updated HydroDyn module of FAST v8. These modules are linked to the rest of FAST through the new coupling scheme involving mapping between module-independent spatial discretizations and a numerically rigorous implicit solver. The results show that the new structural dynamics, hydrodynamics, and coupled solutions compare well to the results from the previous code comparison projects.« less
Interpretation of fast-ion signals during beam modulation experiments

DOE PAGES

Heidbrink, W. W.; Collins, C. S.; Stagner, L.; ...

2016-07-22

Fast-ion signals produced by a modulated neutral beam are used to infer fast-ion transport. The measured quantity is the divergence of perturbed fast-ion flux from the phase-space volume measured by the diagnostic, ∇•more » $$\\bar{Γ}$$. Since velocity-space transport often contributes to this divergence, the phase-space sensitivity of the diagnostic (or “weight function”) plays a crucial role in the interpretation of the signal. The source and sink make major contributions to the signal but their effects are accurately modeled by calculations that employ an exponential decay term for the sink. Recommendations for optimal design of a fast-ion transport experiment are given, illustrated by results from DIII-D measurements of fast-ion transport by Alfv´en eigenmodes. Finally, the signal-to-noise ratio of the diagnostic, systematic uncertainties in the modeling of the source and sink, and the non-linearity of the perturbation all contribute to the error in ∇•$$\\bar{Γ}$$.« less
Real Time Control of the SSC String Magnets

NASA Astrophysics Data System (ADS)

Calvo, O.; Flora, R.; MacPherson, M.

1987-08-01

The system described in this paper, called SECAR, was designed to control the excitation of a test string of magnets for the proposed Superconducting Super Collider (SSC) and will be used to upgrade the present Tevatron Excitation, Control and Regulation (TECAR) hardware and software . It resides in a VME crate and is controlled by a 68020/68881 based CPU running the application software under a real time operating system named VRTX.
Real time control of the SSC string magnets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calvo, O.; Flora, R.; MacPherson, M.

1987-08-01

The system described in this paper, called SECAR, was designed to control the excitation of a test string of magnets for the proposed Superconducting Super Collider (SSC) and will be used to upgrade the present Tevatron Excitation, Control and Regulation (TECAR) hardware and software. It resides in a VME orate and is controlled by a 68020/68881 based CPU running the application software under a real time operating system named VRTX.
A 16 channel discriminator VME board with enhanced triggering capabilities

NASA Astrophysics Data System (ADS)

Borsato, E.; Garfagnini, A.; Menon, G.

2012-08-01

Electronics and data acquisition systems used in small and large scale laboratories often have to handle analog signals with varying polarity, amplitude and duration which have to be digitized to be used as trigger signals to validate the acquired data. In the specific case of experiments dealing with ionizing radiation, ancillary particle detectors (for instance plastic scintillators or Resistive Plate Chambers) are used to trigger and select the impinging particles for the experiment. A novel approach using commercial LVDS line receivers as discriminator devices is presented. Such devices, with a proper calibration, can handle positive and negative analog signals in a wide dynamic range (from 20 mV to 800 mV signal amplitude). The clear advantages, with respect to conventional discriminator devices, are reduced costs, high reliability of a mature technology and the possibility of high integration scale. Moreover, commercial discriminator boards with positive input signal and a wide threshold swing are not available on the market. The present paper describes the design and characterization of a VME board capable to handle 16 differential or single-ended input channels. The output digital signals, available independently for each input, can be combined in the board into three independent trigger logic units which provide additional outputs for the end user.
Tabula diptycha: Differential HIV knowledge, stigma, and intended behavioural outcomes amongst visitors at Vietnam's Pain and Hope exhibition

PubMed Central

Nambiar, Devaki; Nguyen, Mai Huong; Giang, Le Minh; Hirsch, Jennifer

2013-01-01

Stigma reduction efforts in Vietnam have been encumbered by contradictory and dynamic views of People Living With HIV (PLWH) and the epidemic over the past two decades. World AIDS Day 2010 saw the launch of Pain and Hope, a museum exhibition showcasing the lives and experiences of Vietnamese People Living with AIDS at the Vietnam Museum of Ethnology (VME). Between December 2010 and May 2011, a random sample of visitors completed exit surveys regarding attitudes towards the exhibition and Vietnamese living with HIV/AIDS. The survey sought to determine what kind of visitors the museum and exhibition attracted, and the stigma-related impacts of this kind of exposure and parasocial contact. Of 2,500 Vietnamese visitors randomly selected, 852 completed the computer surveys (response rate of 34.1%), 92.3% of whom had seen Pain and Hope. We found two sub-strata or types of visitors attending the exhibition, with varying demographic characteristics, HIV-related knowledge, some differences in stigma ideation, and clear differences in intended behaviours specifically attributable to the exhibition. Social desirability biases notwithstanding, there has emerged a diptych typology of visitors to the VME, for whom the experience of the exhibition is likely interacting with divergent prior knowledge, experiences, interests and motivations. PMID:22974183
Modernization of the NASA IRTF Telescope Control System

NASA Astrophysics Data System (ADS)

Pilger, Eric J.; Harwood, James V.; Onaka, Peter M.

1994-06-01

We describe the ongoing modernization of the NASA IR Telescope Facility Telescope Control System. A major mandate of this project is to keep the telescope available for observations throughout. Therefore, we have developed an incremental plan that will allow us to replace components of the software and hardware without shutting down the system. The current system, running under FORTH on a DEC LSI 11/23 minicomputer interfaced to a Bus and boards developed in house, will be replaced with a combination of a Sun SPARCstation running SunOS, a MicroSPARC based Single Board Computer running LynxOS, and various intelligent VME based peripheral cards. The software is based on a design philosophy originally developed by Pat Wallace for use on the Anglo Australian Telescope. This philosophy has gained wide acceptance, and is currently used in a number of observatories around the world. A key element of this philosophy is the division of the TCS into `Virtual' and `Real' parts. This will allow us to replace the higher level functions of the TCS with software running on the Sun, while still relying on the LSI 11/23 for performance of the lower level functions. Eventual transfer of lower level functions to the MicroSPARC system will then proceed incrementally through use of a Q-Bus to VME-Bus converter.
Fast and precise thermoregulation system in physiological brain slice experiment

NASA Astrophysics Data System (ADS)

Sheu, Y. H.; Young, M. S.

1995-12-01

We have developed a fast and precise thermoregulation system incorporated within a physiological experiment on a brain slice. The thermoregulation system is used to control the temperature of a recording chamber in which the brain slice is placed. It consists of a single-chip microcomputer, a set command module, a display module, and an FLC module. A fuzzy control algorithm was developed and a fuzzy logic controller then designed for achieving fast, smooth thermostatic performance and providing precise temperature control with accuracy to 0.1 °C, from room temperature through 42 °C (experimental temperature range). The fuzzy logic controller is implemented by microcomputer software and related peripheral hardware circuits. Six operating modes of thermoregulation are offered with the system and this can be further extended according to experimental needs. The test results of this study demonstrate that the fuzzy control method is easily implemented by a microcomputer and also verifies that this method provides a simple way to achieve fast and precise high-performance control of a nonlinear thermoregulation system in a physiological brain slice experiment.
Conceptual design of laser fusion reactor KOYO-fast Concepts of reactor system and laser driver

NASA Astrophysics Data System (ADS)

Kozaki, Y.; Miyanaga, N.; Norimatsu, T.; Soman, Y.; Hayashi, T.; Furukawa, H.; Nakatsuka, M.; Yoshida, K.; Nakano, H.; Kubomura, H.; Kawashima, T.; Nishimae, J.; Suzuki, Y.; Tsuchiya, N.; Kanabe, T.; Jitsuno, T.; Fujita, H.; Kawanaka, J.; Tsubakimoto, K.; Fujimoto, Y.; Lu, J.; Matsuoka, S.; Ikegawa, T.; Owadano, Y.; Ueda, K.; Tomabechi, K.; Reactor Design Committee in Ife Forum, Members Of

2006-06-01

We have carried out the design studies of KOYO-Fast laser fusion power plant, using fast ignition cone targets, DPSSL lasers, and LiPb liquid wall chambers. Using fast ignition targets, we could design a middle sized 300 MWe reactor module, with 200 MJ fusion pulse energy and 4 Hz rep-rates, and 1200MWe modular power plants with 4 reactor modules and a 16 Hz laser driver. The liquid wall chambers with free surface cascade flows are proposed for cooling surface quickly enough to a 4 Hz pulse operation. We examined the potential of Yb-YAG ceramic lasers operated at 150˜ 225 K for both implosion and heating laser systems required for a 16-Hz repetition and 8 % total efficiency.
Fast Solvers for Moving Material Interfaces

DTIC Science & Technology

2008-01-01

interface method—with the semi-Lagrangian contouring method developed in References [16–20]. We are now finalizing portable C / C ++ codes for fast adaptive ...stepping scheme couples a CIR predictor with a trapezoidal corrector using the velocity evaluated from the CIR approximation. It combines the...formula with efficient geometric algorithms and fast accurate contouring techniques. A modular adaptive implementation with fast new geometry modules
FAST BUS Test Box (LAIKA) (Engineering Materials)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-01-01

The assembly drawing AD 135-518-00-RO, and the drawings referenced thereon, provide the data and specifications for constructing the LAIKA Test Box. Some drawings are not available, although they are listed on the material lists included. The assembly is a manual tester for FAST BUS modules, both masters and slaves. FAST BUS signals are generated by means of switches or push buttons and provide the state of the bus lines by lighting LED's. The box acts as either a master or slave - depending upon the module under test. It also acts as an ATC to test the arbitration logic ofmore » a master or ATC device.« less
Verification and Validation of Multisegmented Mooring Capabilities in FAST v8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andersen, Morten T.; Wendt, Fabian F.; Robertson, Amy N.

2016-07-01

The quasi-static and dynamic mooring modules of the open-source aero-hydro-servo-elastic wind turbine simulation software, FAST v8, have previously been verified and validated, but only for mooring arrangements consisting of single lines connecting each fairlead and anchor. This paper extends the previous verification and validation efforts to focus on the multisegmented mooring capability of the FAST v8 modules: MAP++, MoorDyn, and the OrcaFlex interface. The OC3-Hywind spar buoy system tested by the DeepCwind consortium at the MARIN ocean basin, which includes a multisegmented bridle layout of the mooring system, was used for the verification and validation activities.
Response of surge protection devices to fast rising pulses

NASA Technical Reports Server (NTRS)

Mindel, I. N.

1980-01-01

Two types of lightning protection modules incorporating leadless (pill type) Zener like devices were evaluated with regard to their ability to suppress EMP induced transients. Two series of tests were performed to evaluate the ability of these modules to react to fast rate of rise ( 1Kv/ns) transients, and the attenuation introduced and the ability to limit damped sinusoid pulses which may be induced due to an EMP resulting from a nuclear detonation.
Graphene field-effect transistors as room-temperature terahertz detectors.

PubMed

Vicarelli, L; Vitiello, M S; Coquillat, D; Lombardo, A; Ferrari, A C; Knap, W; Polini, M; Pellegrini, V; Tredicucci, A

2012-10-01

The unique optoelectronic properties of graphene make it an ideal platform for a variety of photonic applications, including fast photodetectors, transparent electrodes in displays and photovoltaic modules, optical modulators, plasmonic devices, microcavities, and ultra-fast lasers. Owing to its high carrier mobility, gapless spectrum and frequency-independent absorption, graphene is a very promising material for the development of detectors and modulators operating in the terahertz region of the electromagnetic spectrum (wavelengths in the hundreds of micrometres), still severely lacking in terms of solid-state devices. Here we demonstrate terahertz detectors based on antenna-coupled graphene field-effect transistors. These exploit the nonlinear response to the oscillating radiation field at the gate electrode, with contributions of thermoelectric and photoconductive origin. We demonstrate room temperature operation at 0.3 THz, showing that our devices can already be used in realistic settings, enabling large-area, fast imaging of macroscopic samples.
Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature

PubMed Central

Eisenach, James C.; Ririe, Douglas G.

2015-01-01

The ability to distinguish mechanical from thermal input is a critical component of peripheral somatosensory function. Polymodal C fibers respond to both stimuli. However, mechanosensitive, modality-specific fast-conducting tactile and nociceptor afferents theoretically carry information only about mechanical forces independent of the thermal environment. We hypothesize that the thermal environment can nonetheless modulate mechanical force sensibility in fibers that do not respond directly to change in temperature. To study this, fast-conducting mechanosensitive peripheral sensory fibers in male Sprague-Dawley rats were accessed at the soma in the dorsal root ganglia from T11 or L4/L5. Neuronal identification was performed using receptive field characteristics and passive and active electrical properties. Neurons responded to mechanical stimuli but failed to generate action potentials in response to changes in temperature alone, except for the tactile mechanical and cold sensitive neurons. Heat and cold ramps were utilized to determine temperature-induced modulation of response to mechanical stimuli. Mechanically evoked electrical activity in non-nociceptive, low-threshold mechanoreceptors (tactile afferents) decreased in response to changes in temperature while mechanically induced activity was increased in nociceptive, fast-conducting, high-threshold mechanoreceptors in response to the same changes in temperature. These data suggest that mechanical activation does not occur in isolation but rather that temperature changes appear to alter mechanical afferent activity and input to the central nervous system in a dynamic fashion. Further studies to understand the psychophysiological implications of thermal modulation of fast-conducting mechanical input to the spinal cord will provide greater insight into the implications of these findings. PMID:26581873
Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

PubMed Central

Goldstein, Ido; Baek, Songjoon; Presman, Diego M.; Paakinaho, Ville; Swinstead, Erin E.; Hager, Gordon L.

2017-01-01

Fasting elicits transcriptional programs in hepatocytes leading to glucose and ketone production. This transcriptional program is regulated by many transcription factors (TFs). To understand how this complex network regulates the metabolic response to fasting, we aimed at isolating the enhancers and TFs dictating it. Measuring chromatin accessibility revealed that fasting massively reorganizes liver chromatin, exposing numerous fasting-induced enhancers. By utilizing computational methods in combination with dissecting enhancer features and TF cistromes, we implicated four key TFs regulating the fasting response: glucocorticoid receptor (GR), cAMP responsive element binding protein 1 (CREB1), peroxisome proliferator activated receptor alpha (PPARA), and CCAAT/enhancer binding protein beta (CEBPB). These TFs regulate fuel production by two distinctly operating modules, each controlling a separate metabolic pathway. The gluconeogenic module operates through assisted loading, whereby GR doubles the number of sites occupied by CREB1 as well as enhances CREB1 binding intensity and increases accessibility of CREB1 binding sites. Importantly, this GR-assisted CREB1 binding was enhancer-selective and did not affect all CREB1-bound enhancers. Single-molecule tracking revealed that GR increases the number and DNA residence time of a portion of chromatin-bound CREB1 molecules. These events collectively result in rapid synergistic gene expression and higher hepatic glucose production. Conversely, the ketogenic module operates via a GR-induced TF cascade, whereby PPARA levels are increased following GR activation, facilitating gradual enhancer maturation next to PPARA target genes and delayed ketogenic gene expression. Our findings reveal a complex network of enhancers and TFs that dynamically cooperate to restore homeostasis upon fasting. PMID:28031249

Control system for 5 MW neutral beam ion source for SST1

NASA Astrophysics Data System (ADS)

Patel, G. B.; Onali, Raja; Sharma, Vivek; Suresh, S.; Tripathi, V.; Bandyopadhyay, M.; Singh, N. P.; Thakkar, Dipal; Gupta, L. N.; Singh, M. J.; Patel, P. J.; Chakraborty, A. K.; Baruah, U. K.; Mattoo, S. K.

2006-01-01

This article describes the control system for a 5MW ion source of the NBI (neutral beam injector) for steady-state superconducting tokamak-1 (SST-1). The system uses both hardware and software solutions. It comprises a DAS (data acquisition system) and a control system. The DAS is used to read the voltage and current signals from eight filament heater power supplies and 24 discharge power supplies. The control system is used to adjust the filament heater current in order to achieve an effective control on the discharge current in the plasma box. The system consists of a VME (Verse Module Eurocard) system and C application program running on a VxWorks™ real-time operating system. A PID (proportional, integral, and differential) algorithm is used to control the filament heater current. Experiments using this system have shown that the discharge current can be controlled within 1% accuracy for a PID loop time of 20ms. Response of the control system to the pressure variation of the gas in the chamber has also been studied and compared with the results obtained from those of an uncontrolled system. The present approach increases the flexibility of the control system. It not only eases the control of the plasma but also allows an easy changeover to various operation scenarios.
Upgrade to the control system of the reflectometry diagnostic of ASDEX upgrade

NASA Astrophysics Data System (ADS)

Graça, S.; Santos, J.; Manso, M. E.

2004-10-01

The broadband frequency modulation-continuous wave microwave/millimeter wave reflectometer of ASDEX upgrade tokamak (Institut für Plasma Physik (IPP), Garching, Germany) developed by Centro de Fusão Nuclear (Lisboa, Portugal) with the collaboration of IPP, is a complex system with 13 channels (O and X modes) and two types of operation modes (swept and fixed frequency). The control system that ensures remote operation of the diagnostic incorporates VME and CAMAC bus based acquisition/timing systems. Microprocessor input/output boards are used to control and monitor the microwave circuitry and associated electronic devices. The implementation of the control system is based on an object-oriented client/server model: a centralized server manages the hardware and receives input from remote clients. Communication is handled through transmission control protocol/internet protocol sockets. Here we describe recent upgrades of the control system aiming to: (i) accommodate new channels; (ii) adapt to the heterogeneity of computing platforms and operating systems; and (iii) overcome remote access restrictions. Platform and operating system independence was achieved by redesigning the graphical user interface in JAVA. As secure shell is the standard remote access protocol adopted in major fusion laboratories, secure shell tunneling was implemented to allow remote operation of the diagnostic through the existing firewalls.
Third generation of correlators for six antennas

NASA Astrophysics Data System (ADS)

Torres, Marc

2000-07-01

The technical evolution of the correlators of the Plateau de Bure interferometer since the first fringes, 14 years ago, is shortly presented. The progressive addition of antennas over this period has allowed the Grenoble correlator group to undertake several 'start-from-scratch' designs, which have replaced on-site equipment as it came obsolete. The tradeoff between design cycle time and lifetime of such equipment is discussed. The latest design is described in detail. The new correlator can be set to analyze up to eight simultaneous windows, adjustable in size and center frequency, thanks to a 2 X 220 MHz image rejection mixer. Advantages of analog IF processing are presented. The frequency plan of the IF processor has been designed to be fully compatible with MarkIV VLBI recording. The correlator is then used to sum up the signals of the 6 antennas over 256 MHz. The digital section mainly uses an IRAM-designed low-power, low-cost ASIC. Delay lines use FPGA's and phase rotators use DDS's. Surface-mount technology is used everywhere. A commercial CPU module runs the real-time software under Linux. A 21-slot VME chassis hosts the hardware. Test results and measurements of performance on the full-size machine are presented. The difficulties encountered in achieving this kind of machine within schedule in today's industrial environment are retrospectively analyzed.
Data Telemetry and Acquisition System for Acoustic Signal Processing Investigations.

DTIC Science & Technology

1996-02-20

were VME- based computer systems operating under the VxWorks real - time operating system . Each system shared a common hardware and software... real - time operating system . It interfaces to the Berg PCM Decommutator board, which searches for the embedded synchronization word in the data and re...software were built on top of this architecture. The multi-tasking, message queue and memory management facilities of the VxWorks real - time operating system are
Bubble memory module for spacecraft application

NASA Technical Reports Server (NTRS)

Hayes, P. J.; Looney, K. T.; Nichols, C. D.

1985-01-01

Bubble domain technology offers an all-solid-state alternative for data storage in onboard data systems. A versatile modular bubble memory concept was developed. The key module is the bubble memory module which contains all of the storage devices and circuitry for accessing these devices. This report documents the bubble memory module design and preliminary hardware designs aimed at memory module functional demonstration with available commercial bubble devices. The system architecture provides simultaneous operation of bubble devices to attain high data rates. Banks of bubble devices are accessed by a given bubble controller to minimize controller parts. A power strobing technique is discussed which could minimize the average system power dissipation. A fast initialization method using EEPROM (electrically erasable, programmable read-only memory) devices promotes fast access. Noise and crosstalk problems and implementations to minimize these are discussed. Flight memory systems which incorporate the concepts and techniques of this work could now be developed for applications.
Design of an ultra low power third order continuous time current mode ΣΔ modulator for WLAN applications.

PubMed

Behzadi, Kobra; Baghelani, Masoud

2014-05-01

This paper presents a third order continuous time current mode ΣΔ modulator for WLAN 802.11b standard applications. The proposed circuit utilized feedback architecture with scaled and optimized DAC coefficients. At circuit level, we propose a modified cascade current mirror integrator with reduced input impedance which results in more bandwidth and linearity and hence improves the dynamic range. Also, a very fast and precise novel dynamic latch based current comparator is introduced with low power consumption. This ultra fast comparator facilitates increasing the sampling rate toward GHz frequencies. The modulator exhibits dynamic range of more than 60 dB for 20 MHz signal bandwidth and OSR of 10 while consuming only 914 μW from 1.8 V power supply. The FoM of the modulator is calculated from two different methods, and excellent performance is achieved for proposed modulator.
Design of an ultra low power third order continuous time current mode ΣΔ modulator for WLAN applications

PubMed Central

Behzadi, Kobra; Baghelani, Masoud

2013-01-01

This paper presents a third order continuous time current mode ΣΔ modulator for WLAN 802.11b standard applications. The proposed circuit utilized feedback architecture with scaled and optimized DAC coefficients. At circuit level, we propose a modified cascade current mirror integrator with reduced input impedance which results in more bandwidth and linearity and hence improves the dynamic range. Also, a very fast and precise novel dynamic latch based current comparator is introduced with low power consumption. This ultra fast comparator facilitates increasing the sampling rate toward GHz frequencies. The modulator exhibits dynamic range of more than 60 dB for 20 MHz signal bandwidth and OSR of 10 while consuming only 914 μW from 1.8 V power supply. The FoM of the modulator is calculated from two different methods, and excellent performance is achieved for proposed modulator. PMID:25685504
Verification and Validation of the New Dynamic Mooring Modules Available in FAST v8: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wendt, Fabian; Robertson, Amy; Jonkman, Jason

2016-08-01

The open-source aero-hydro-servo-elastic wind turbine simulation software, FAST v8, was recently coupled to two newly developed mooring dynamics modules: MoorDyn and FEAMooring. MoorDyn is a lumped-mass-based mooring dynamics module developed by the University of Maine, and FEAMooring is a finite-element-based mooring dynamics module developed by Texas A&M University. This paper summarizes the work performed to verify and validate these modules against other mooring models and measured test data to assess their reliability and accuracy. The quality of the fairlead load predictions by the open-source mooring modules MoorDyn and FEAMooring appear to be largely equivalent to what is predicted by themore » commercial tool OrcaFlex. Both mooring dynamic model predictions agree well with the experimental data, considering the given limitations in the accuracy of the platform hydrodynamic load calculation and the quality of the measurement data.« less
Verification and Validation of the New Dynamic Mooring Modules Available in FAST v8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wendt, Fabian F.; Andersen, Morten T.; Robertson, Amy N.

2016-07-01

The open-source aero-hydro-servo-elastic wind turbine simulation software, FAST v8, was recently coupled to two newly developed mooring dynamics modules: MoorDyn and FEAMooring. MoorDyn is a lumped-mass-based mooring dynamics module developed by the University of Maine, and FEAMooring is a finite-element-based mooring dynamics module developed by Texas A&M University. This paper summarizes the work performed to verify and validate these modules against other mooring models and measured test data to assess their reliability and accuracy. The quality of the fairlead load predictions by the open-source mooring modules MoorDyn and FEAMooring appear to be largely equivalent to what is predicted by themore » commercial tool OrcaFlex. Both mooring dynamic model predictions agree well with the experimental data, considering the given limitations in the accuracy of the platform hydrodynamic load calculation and the quality of the measurement data.« less
A fast method for optical simulation of flood maps of light-sharing detector modules

PubMed Central

Shi, Han; Du, Dong; Xu, JianFeng; Moses, William W.; Peng, Qiyu

2016-01-01

Optical simulation of the detector module level is highly desired for Position Emission Tomography (PET) system design. Commonly used simulation toolkits such as GATE are not efficient in the optical simulation of detector modules with complicated light-sharing configurations, where a vast amount of photons need to be tracked. We present a fast approach based on a simplified specular reflectance model and a structured light-tracking algorithm to speed up the photon tracking in detector modules constructed with polished finish and specular reflector materials. We simulated conventional block detector designs with different slotted light guide patterns using the new approach and compared the outcomes with those from GATE simulations. While the two approaches generated comparable flood maps, the new approach was more than 200–600 times faster. The new approach has also been validated by constructing a prototype detector and comparing the simulated flood map with the experimental flood map. The experimental flood map has nearly uniformly distributed spots similar to those in the simulated flood map. In conclusion, the new approach provides a fast and reliable simulation tool for assisting in the development of light-sharing-based detector modules with a polished surface finish and using specular reflector materials. PMID:27660376
A fast method for optical simulation of flood maps of light-sharing detector modules

DOE PAGES

Shi, Han; Du, Dong; Xu, JianFeng; ...

2015-09-03

Optical simulation of the detector module level is highly desired for Position Emission Tomography (PET) system design. Commonly used simulation toolkits such as GATE are not efficient in the optical simulation of detector modules with complicated light-sharing configurations, where a vast amount of photons need to be tracked. Here, we present a fast approach based on a simplified specular reflectance model and a structured light-tracking algorithm to speed up the photon tracking in detector modules constructed with polished finish and specular reflector materials. We also simulated conventional block detector designs with different slotted light guide patterns using the new approachmore » and compared the outcomes with those from GATE simulations. And while the two approaches generated comparable flood maps, the new approach was more than 200–600 times faster. The new approach has also been validated by constructing a prototype detector and comparing the simulated flood map with the experimental flood map. The experimental flood map has nearly uniformly distributed spots similar to those in the simulated flood map. In conclusion, the new approach provides a fast and reliable simulation tool for assisting in the development of light-sharing-based detector modules with a polished surface finish and using specular reflector materials.« less
Light-curve Modulation of Low-mass Stars in K2. I. Identification of 481 Fast Rotators in the Solar Neighborhood

NASA Astrophysics Data System (ADS)

Saylor, Dicy; Lepine, Sebastien; Crossfield, Ian; Petigura, Erik A.

2018-01-01

The K2 mission is targeting large numbers of nearby (d < 100 pc) GKM dwarfs selected from the SUPERBLINK proper motion survey (μ > 40 mas yr‑1, V < 20). Additionally, the mission is targeting low-mass, high proper motion stars associated with the local (d < 500 pc) Galactic halo population also selected from SUPERBLINK. K2 campaigns 0 through 8 monitored a total of 26,518 of these cool main-sequence stars. We used the auto-correlation function to search for fast rotators by identifying short-period photometric modulations in the K2 light curves. We identified 481 candidate fast rotators with rotation periods <4 days that show light-curve modulations consistent with starspots. Their kinematics show low average transverse velocities, suggesting that they are part of the young disk population. A subset (13) of the fast rotators is found among those targets with colors and kinematics consistent with the local Galactic halo population and may represent stars spun up by tidal interactions in close binary systems. We further demonstrate that the M dwarf fast rotators selected from the K2 light curves are significantly more likely to have UV excess and discuss the potential of the K2 mission to identify new nearby young GKM dwarfs on the basis of their fast rotation rates. Finally, we discuss the possible use of local halo stars as fiducial, non-variable sources in the Kepler fields.
Verification and Validation of Multisegmented Mooring Capabilities in FAST v8: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andersen, Morten T.; Wendt, Fabian; Robertson, Amy

2016-08-01

The quasi-static and dynamic mooring modules of the open-source aero-hydro-servo-elastic wind turbine simulation software, FAST v8, have previously been verified and validated, but only for mooring arrangements consisting of single lines connecting each fairlead and anchor. This paper extends the previous verification and validation efforts to focus on the multisegmented mooring capability of the FAST v8 modules: MAP++, MoorDyn, and the OrcaFlex interface. The OC3-Hywind spar buoy system tested by the DeepCwind consortium at the MARIN ocean basin, which includes a multisegmented bridle layout of the mooring system, was used for the verification and validation activities.
Evaluation and application of a fast module in a PLC based interlock and control system

NASA Astrophysics Data System (ADS)

Zaera-Sanz, M.

2009-08-01

The LHC Beam Interlock system requires a controller performing a simple matrix function to collect the different beam dump requests. To satisfy the expected safety level of the Interlock, the system should be robust and reliable. The PLC is a promising candidate to fulfil both aspects but too slow to meet the expected response time which is of the order of μseconds. Siemens has introduced a ``so called'' fast module (FM352-5 Boolean Processor). It provides independent and extremely fast control of a process within a larger control system using an onboard processor, a Field Programmable Gate Array (FPGA), to execute code in parallel which results in extremely fast scan times. It is interesting to investigate its features and to evaluate it as a possible candidate for the beam interlock system. This paper publishes the results of this study. As well, this paper could be useful for other applications requiring fast processing using a PLC.
Modulation format identification enabled by the digital frequency-offset loading technique for hitless coherent transceiver.

PubMed

Fu, Songnian; Xu, Zuying; Lu, Jianing; Jiang, Hexun; Wu, Qiong; Hu, Zhouyi; Tang, Ming; Liu, Deming; Chan, Calvin Chun-Kit

2018-03-19

We propose a blind and fast modulation format identification (MFI) enabled by the digital frequency-offset (FO) loading technique for hitless coherent transceiver. Since modulation format information is encoded to the FO distribution during digital signal processing (DSP) at the transmitter side (Tx), we can use the fast Fourier transformation based FO estimation (FFT-FOE) method to obtain the FO distribution of individual data block after constant modulus algorithm (CMA) pre-equalization at the receiver side, in order to realize non-data-aided (NDA) and fast MFI. The obtained FO can be also used for subsequent FO compensation (FOC), without additional complexity. We numerically investigate and experimentally verify the proposed MFI with high accuracy and fast format switching among 28 Gbaud dual-polarization (DP)-4/8/16/64QAM, time domain hybrid-4/16QAM, and set partitioning (SP)-128QAM. In particular, the proposed MFI brings no performance degradation, in term of tolerance of amplified spontaneous emission (ASE) noise, laser linewidth, and fiber nonlinearity. Finally, a hitless coherent transceiver enabled by the proposed MFI with switching-block of only 2048 symbols is demonstrated over 1500 km standard single mode fiber (SSMF) transmission.
Demonstration of the Cascadia G‐FAST geodetic earthquake early warning system for the Nisqually, Washington, earthquake

USGS Publications Warehouse

Crowell, Brendan; Schmidt, David; Bodin, Paul; Vidale, John; Gomberg, Joan S.; Hartog, Renate; Kress, Victor; Melbourne, Tim; Santillian, Marcelo; Minson, Sarah E.; Jamison, Dylan

2016-01-01

A prototype earthquake early warning (EEW) system is currently in development in the Pacific Northwest. We have taken a two‐stage approach to EEW: (1) detection and initial characterization using strong‐motion data with the Earthquake Alarm Systems (ElarmS) seismic early warning package and (2) the triggering of geodetic modeling modules using Global Navigation Satellite Systems data that help provide robust estimates of large‐magnitude earthquakes. In this article we demonstrate the performance of the latter, the Geodetic First Approximation of Size and Time (G‐FAST) geodetic early warning system, using simulated displacements for the 2001Mw 6.8 Nisqually earthquake. We test the timing and performance of the two G‐FAST source characterization modules, peak ground displacement scaling, and Centroid Moment Tensor‐driven finite‐fault‐slip modeling under ideal, latent, noisy, and incomplete data conditions. We show good agreement between source parameters computed by G‐FAST with previously published and postprocessed seismic and geodetic results for all test cases and modeling modules, and we discuss the challenges with integration into the U.S. Geological Survey’s ShakeAlert EEW system.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Harper, Jason

Jason Harper, an electrical engineer in Argonne National Laboratory's EV-Smart Grid Interoperability Center, discusses his SpEC Module invention that will enable fast charging of electric vehicles in under 15 minutes. The module has been licensed to BTCPower.
Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response.

PubMed

Goldstein, Ido; Baek, Songjoon; Presman, Diego M; Paakinaho, Ville; Swinstead, Erin E; Hager, Gordon L

2017-03-01

Fasting elicits transcriptional programs in hepatocytes leading to glucose and ketone production. This transcriptional program is regulated by many transcription factors (TFs). To understand how this complex network regulates the metabolic response to fasting, we aimed at isolating the enhancers and TFs dictating it. Measuring chromatin accessibility revealed that fasting massively reorganizes liver chromatin, exposing numerous fasting-induced enhancers. By utilizing computational methods in combination with dissecting enhancer features and TF cistromes, we implicated four key TFs regulating the fasting response: glucocorticoid receptor (GR), cAMP responsive element binding protein 1 (CREB1), peroxisome proliferator activated receptor alpha (PPARA), and CCAAT/enhancer binding protein beta (CEBPB). These TFs regulate fuel production by two distinctly operating modules, each controlling a separate metabolic pathway. The gluconeogenic module operates through assisted loading, whereby GR doubles the number of sites occupied by CREB1 as well as enhances CREB1 binding intensity and increases accessibility of CREB1 binding sites. Importantly, this GR-assisted CREB1 binding was enhancer-selective and did not affect all CREB1-bound enhancers. Single-molecule tracking revealed that GR increases the number and DNA residence time of a portion of chromatin-bound CREB1 molecules. These events collectively result in rapid synergistic gene expression and higher hepatic glucose production. Conversely, the ketogenic module operates via a GR-induced TF cascade, whereby PPARA levels are increased following GR activation, facilitating gradual enhancer maturation next to PPARA target genes and delayed ketogenic gene expression. Our findings reveal a complex network of enhancers and TFs that dynamically cooperate to restore homeostasis upon fasting. Published by Cold Spring Harbor Laboratory Press.
Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature.

PubMed

Boada, M Danilo; Eisenach, James C; Ririe, Douglas G

2016-01-01

The ability to distinguish mechanical from thermal input is a critical component of peripheral somatosensory function. Polymodal C fibers respond to both stimuli. However, mechanosensitive, modality-specific fast-conducting tactile and nociceptor afferents theoretically carry information only about mechanical forces independent of the thermal environment. We hypothesize that the thermal environment can nonetheless modulate mechanical force sensibility in fibers that do not respond directly to change in temperature. To study this, fast-conducting mechanosensitive peripheral sensory fibers in male Sprague-Dawley rats were accessed at the soma in the dorsal root ganglia from T11 or L4/L5. Neuronal identification was performed using receptive field characteristics and passive and active electrical properties. Neurons responded to mechanical stimuli but failed to generate action potentials in response to changes in temperature alone, except for the tactile mechanical and cold sensitive neurons. Heat and cold ramps were utilized to determine temperature-induced modulation of response to mechanical stimuli. Mechanically evoked electrical activity in non-nociceptive, low-threshold mechanoreceptors (tactile afferents) decreased in response to changes in temperature while mechanically induced activity was increased in nociceptive, fast-conducting, high-threshold mechanoreceptors in response to the same changes in temperature. These data suggest that mechanical activation does not occur in isolation but rather that temperature changes appear to alter mechanical afferent activity and input to the central nervous system in a dynamic fashion. Further studies to understand the psychophysiological implications of thermal modulation of fast-conducting mechanical input to the spinal cord will provide greater insight into the implications of these findings. Copyright © 2016 the American Physiological Society.
Fast spatial beam shaping by acousto-optic diffraction for 3D non-linear microscopy.

PubMed

Akemann, Walther; Léger, Jean-François; Ventalon, Cathie; Mathieu, Benjamin; Dieudonné, Stéphane; Bourdieu, Laurent

2015-11-02

Acousto-optic deflection (AOD) devices offer unprecedented fast control of the entire spatial structure of light beams, most notably their phase. AOD light modulation of ultra-short laser pulses, however, is not straightforward to implement because of intrinsic chromatic dispersion and non-stationarity of acousto-optic diffraction. While schemes exist to compensate chromatic dispersion, non-stationarity remains an obstacle. In this work we demonstrate an efficient AOD light modulator for stable phase modulation using time-locked generation of frequency-modulated acoustic waves at the full repetition rate of a high power laser pulse amplifier of 80 kHz. We establish the non-local relationship between the optical phase and the generating acoustic frequency function and verify the system for temporal stability, phase accuracy and generation of non-linear two-dimensional phase functions.

Fast Ion Effects During Test Blanket Module Simulation Experiments in DIII-D

NASA Astrophysics Data System (ADS)

Kramer, G. J.; Budny, R.; Nazikian, R.; Heidbrink, W. W.; Kurki-Suonio, T.; Salmi, A.; Schaffer, M. J.; van Zeeland, M. A.; Shinohara, K.; Snipes, J. A.; Spong, D.

2010-11-01

The fast beam-ion confinement in the presence of a scaled mock-up of two Test Blanket Modules (TBM) for ITER was studied in DIII-D. The TBM on DIII-D has four vertically arranged protective carbon tiles with thermocouples placed at the back of each tile. Temperature increases of up to 200^oC were measured for the two tiles closest to the midplane when the TBM fields were present. These measurements agree qualitatively with results from the full orbit-following beam-ion code, SPIRAL, that predict beam-ion losses to be localized on the central two carbon tiles when the TBM fields present. Within the experimental uncertainties no significant change in the fast-ion population was found in the core of these plasmas which is consistent with SPIRAL analysis. These experiments indicate that the TBM fields do not affect the fast-ion confinement in a harmful way which is good news for ITER.
NASA Tech Briefs, September 2007

NASA Technical Reports Server (NTRS)

2007-01-01

Topics covered include; Rapid Fabrication of Carbide Matrix/Carbon Fiber Composites; Coating Thermoelectric Devices To Suppress Sublimation; Ultrahigh-Temperature Ceramics; Improved C/SiC Ceramic Composites Made Using PIP; Coating Carbon Fibers With Platinum; Two-Band, Low-Loss Microwave Window; MCM Polarimetric Radiometers for Planar Arrays; Aperture-Coupled Thin-Membrane L-Band Antenna; WGM-Based Photonic Local Oscillators and Modulators; Focal-Plane Arrays of Quantum-Dot Infrared Photodetectors; Laser Range and Bearing Finder With No Moving Parts; Microrectenna: A Terahertz Antenna and Rectifier on a Chip; Miniature L-Band Radar Transceiver; Robotic Vision-Based Localization in an Urban Environment; Programs for Testing an SSME-Monitoring System; Cathodoluminescent Source of Intense White Light; Displaying and Analyzing Antenna Radiation Patterns; Payload Operations Support Team Tools; Space-Shuttle Emulator Software; Soft Real-Time PID Control on a VME Computer; Analyzing Radio-Frequency Coverage for the ISS; Nanorod-Based Fast-Response Pressure-Sensitive Paints; Capacitors Would Help Protect Against Hypervelocity Impacts; Diaphragm Pump With Resonant Piezoelectric Drive; Improved Quick-Release Pin Mechanism; Designing Rolling-Element Bearings; Reverse-Tangent Injection in a Centrifugal Compressor; Inertial Measurements for Aero-assisted Navigation (IMAN); Analysis of Complex Valve and Feed Systems; Improved Path Planning Onboard the Mars Exploration Rovers; Robust, Flexible Motion Control for the Mars Explorer Rovers; Solar Sail Spaceflight Simulation; Fluorine-Based DRIE of Fused Silica; Mechanical Alloying for Making Thermoelectric Compounds; Process for High-Rate Fabrication of Alumina Nanotemplates; Electroform/Plasma-Spray Laminates for X-Ray Optics; An Automated Flying-Insect Detection System; Calligraphic Poling of Ferroelectric Material; Blackbody Cavity for Calibrations at 200 to 273 K; KML Super Overlay to WMS Translator; High-Performance Tiled WMS and KML Web Server; Modeling of Radiative Transfer in Protostellar Disks; Composite Pulse Tube; Photometric Calibration of Consumer Video Cameras; Criterion for Identifying Vortices in High- Pressure Flows; Amplified Thermionic Cooling Using Arrays of Nanowires; Delamination-Indicating Thermal Barrier Coatings; Preventing Raman Lasing in High-Q WGM Resonators; Procedures for Tuning a Multiresonator Photonic Filter; Robust Mapping of Incoherent Fiber-Optic Bundles; Extended-Range Ultrarefractive 1D Photonic Crystal Prisms; Rapid Analysis of Mass Distribution of Radiation Shielding; Modeling Magnetic Properties in EZTB; Deep Space Network Antenna Logic Controller; Modeling Carbon and Hydrocarbon Molecular Structures in EZTB; BigView Image Viewing on Tiled Displays; and Imaging Sensor Flight and Test Equipment Software.
Realization of pure frequency modulation of DFB laser via combined optical and electrical tuning.

PubMed

Tian, Chao; Chen, I-Chun Anderson; Park, Seong-Wook; Martini, Rainer

2013-04-08

In this paper we present a novel approach to convert AM signal into FM signal in semiconductor lasers via off resonance optical pumping and report on experimental results obtained with a commercial DFB laser. Aside of demonstrating discrete and fast frequency modulation, we achieve pure frequency modulation through combination with electrical modulation suppressing the associated amplitude modulation, which is detrimental to application such as spectroscopy and communication.
Synchronous-digitization for Video Rate Polarization Modulated Beam Scanning Second Harmonic Generation Microscopy.

PubMed

Sullivan, Shane Z; DeWalt, Emma L; Schmitt, Paul D; Muir, Ryan M; Simpson, Garth J

2015-03-09

Fast beam-scanning non-linear optical microscopy, coupled with fast (8 MHz) polarization modulation and analytical modeling have enabled simultaneous nonlinear optical Stokes ellipsometry (NOSE) and linear Stokes ellipsometry imaging at video rate (15 Hz). NOSE enables recovery of the complex-valued Jones tensor that describes the polarization-dependent observables, in contrast to polarimetry, in which the polarization stated of the exciting beam is recorded. Each data acquisition consists of 30 images (10 for each detector, with three detectors operating in parallel), each of which corresponds to polarization-dependent results. Processing of this image set by linear fitting contracts down each set of 10 images to a set of 5 parameters for each detector in second harmonic generation (SHG) and three parameters for the transmittance of the fundamental laser beam. Using these parameters, it is possible to recover the Jones tensor elements of the sample at video rate. Video rate imaging is enabled by performing synchronous digitization (SD), in which a PCIe digital oscilloscope card is synchronized to the laser (the laser is the master clock.) Fast polarization modulation was achieved by modulating an electro-optic modulator synchronously with the laser and digitizer, with a simple sine-wave at 1/10th the period of the laser, producing a repeating pattern of 10 polarization states. This approach was validated using Z-cut quartz, and NOSE microscopy was performed for micro-crystals of naproxen.
Synchronous-digitization for video rate polarization modulated beam scanning second harmonic generation microscopy

NASA Astrophysics Data System (ADS)

Sullivan, Shane Z.; DeWalt, Emma L.; Schmitt, Paul D.; Muir, Ryan D.; Simpson, Garth J.

2015-03-01

Fast beam-scanning non-linear optical microscopy, coupled with fast (8 MHz) polarization modulation and analytical modeling have enabled simultaneous nonlinear optical Stokes ellipsometry (NOSE) and linear Stokes ellipsometry imaging at video rate (15 Hz). NOSE enables recovery of the complex-valued Jones tensor that describes the polarization-dependent observables, in contrast to polarimetry, in which the polarization stated of the exciting beam is recorded. Each data acquisition consists of 30 images (10 for each detector, with three detectors operating in parallel), each of which corresponds to polarization-dependent results. Processing of this image set by linear fitting contracts down each set of 10 images to a set of 5 parameters for each detector in second harmonic generation (SHG) and three parameters for the transmittance of the fundamental laser beam. Using these parameters, it is possible to recover the Jones tensor elements of the sample at video rate. Video rate imaging is enabled by performing synchronous digitization (SD), in which a PCIe digital oscilloscope card is synchronized to the laser (the laser is the master clock.) Fast polarization modulation was achieved by modulating an electro-optic modulator synchronously with the laser and digitizer, with a simple sine-wave at 1/10th the period of the laser, producing a repeating pattern of 10 polarization states. This approach was validated using Z-cut quartz, and NOSE microscopy was performed for micro-crystals of naproxen.
A surface ice module for wind turbine dynamic response simulation using FAST

DOE PAGES

Yu, Bingbin; Karr, Dale G.; Song, Huimin; ...

2016-06-03

It is a fact that developing offshore wind energy has become more and more serious worldwide in recent years. Many of the promising offshore wind farm locations are in cold regions that may have ice cover during wintertime. The challenge of possible ice loads on offshore wind turbines raises the demand of modeling capacity of dynamic wind turbine response under the joint action of ice, wind, wave, and current. The simulation software FAST is an open source computer-aided engineering (CAE) package maintained by the National Renewable Energy Laboratory. In this paper, a new module of FAST for assessing the dynamicmore » response of offshore wind turbines subjected to ice forcing is presented. In the ice module, several models are presented which involve both prescribed forcing and coupled response. For conditions in which the ice forcing is essentially decoupled from the structural response, ice forces are established from existing models for brittle and ductile ice failure. For conditions in which the ice failure and the structural response are coupled, such as lock-in conditions, a rate-dependent ice model is described, which is developed in conjunction with a new modularization framework for FAST. In this paper, analytical ice mechanics models are presented that incorporate ice floe forcing, deformation, and failure. For lower speeds, forces slowly build until the ice strength is reached and ice fails resulting in a quasi-static condition. For intermediate speeds, the ice failure can be coupled with the structural response and resulting in coinciding periods of the ice failure and the structural response. A third regime occurs at high speeds of encounter in which brittle fracturing of the ice feature occurs in a random pattern, which results in a random vibration excitation of the structure. An example wind turbine response is simulated under ice loading of each of the presented models. This module adds to FAST the capabilities for analyzing the response of wind turbines subjected to forces resulting from ice impact on the turbine support structure. The conditions considered in this module are specifically addressed in the International Organization for Standardization (ISO) standard 19906:2010 for arctic offshore structures design consideration. Special consideration of lock-in vibrations is required due to the detrimental effects of such response with regard to fatigue and foundation/soil response. Finally, the use of FAST for transient, time domain simulation with the new ice module is well suited for such analyses.« less
Introduction to Reactor Statics Modules, RS-1. Nuclear Engineering Computer Modules.

ERIC Educational Resources Information Center

Edlund, Milton C.

The nine Reactor Statics Modules are designed to introduce students to the use of numerical methods and digital computers for calculation of neutron flux distributions in space and energy which are needed to calculate criticality, power distribution, and fuel burn-up for both slow neutron and fast neutron fission reactors. The diffusion…
Flow-induced birefringence measurement system using dual-crystal transverse electro-optic modulator for microgravity fluid physics applications

NASA Technical Reports Server (NTRS)

Mackey, Jeffrey R.

1999-01-01

We have developed a new instrument that can measure fast transient birefringence and polymer chain orientation angle in complex fluids. The instrument uses a dual-crystal transverse electro-optic modulator with the second crystal's modulation voltage applied 180 deg out of phase from that of the first crystal. In this manner, the second crystal compensates for the intrinsic static birefringence of the first crystal, and it doubles the modulation depth. By incorporating a transverse electro-optic modulator with two lithium-niobate (LiNbO3) crystals oriented orthogonal to each other with a custom-designed optical system, we have produced a very small robust instrument capable of fast transient retardation measurements. By measuring the sample thickness or optical path length through the sample, we can calculate the transient birefringence. This system can also measure dichroism. We have compared the calibration results and retardation and orientation angle measurements of this instrument with those of a photoelastic modulator (PEM) based system using a quarter wave plate and a high-precision 1/16-wave plate to simulate a birefringent sample. Transient birefringence measurements on the order of 10(exp -9) can be measured using either modulator.
Reducing microwave absorption with fast frequency modulation.

PubMed

Qin, Juehang; Hubler, A

2017-05-01

We study the response of a two-level quantum system to a chirp signal, using both numerical and analytical methods. The numerical method is based on numerical solutions of the Schrödinger solution of the two-level system, while the analytical method is based on an approximate solution of the same equations. We find that when two-level systems are perturbed by a chirp signal, the peak population of the initially unpopulated state exhibits a high sensitivity to frequency modulation rate. We also find that the aforementioned sensitivity depends on the strength of the forcing, and weaker forcings result in a higher sensitivity, where the frequency modulation rate required to produce the same reduction in peak population would be lower. We discuss potential applications of this result in the field of microwave power transmission, as it shows applying fast frequency modulation to transmitted microwaves used for power transmission could decrease unintended absorption of microwaves by organic tissue.
5nsec Dead time multichannel scaling system for Mössbauer spectrometer

NASA Astrophysics Data System (ADS)

Verrastro, C.; Trombetta, G.; Pita, A.; Saragovi, C.; Duhalde, S.

1991-11-01

A PC programmable and fast multichannel scaling module has been designed to use a commercial Mössbauer spectrometer. This module is based on a 10 single chip 8 bits microcomputer (MC6805) and on a 35 fast ALU, which allows a high performance and low cost system. The module can operate in a stand-alone mode. Data analysis are performed in real time display, on XT/AT IBM PC or compatibles. The channels are ranged between 256 and 4096, the maximum number of counts is 232-1 per channel, the dwell time is 3 μsec and the dead time between channels is 5 nsec. A friendly software display the real time spectrum and offers menues with different options at each state.
Carbapenem Susceptibility Testing Errors Using Three Automated Systems, Disk Diffusion, Etest, and Broth Microdilution and Carbapenem Resistance Genes in Isolates of Acinetobacter baumannii-calcoaceticus Complex

DTIC Science & Technology

2011-10-01

Phoenix, and Vitek 2 systems). Discordant results were categorized as very major errors (VME), major errors (ME), and minor errors (mE). DNA sequences...01 OCT 2011 2 . REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Carbapenem Susceptibility Testing Errors Using Three Automated...FDA standards required for device approval (11). The Vitek 2 method was the only automated susceptibility method in our study that satisfied FDA
Multiple Target Tracking in a Wide-Field-of-View Camera System

DTIC Science & Technology

1990-01-01

assembly is mounted on a Contraves alt-azi axis table with a pointing accuracy of < 2 Urad. * Work performed under the auspices of the U.S. Department of... Contraves SUN 3 CCD DR11W VME EITHERNET SUN 3 !3T 3 RS170 Video 1 Video ^mglifier^ I WWV Clock VCR Datacube u Monitor Monitor UL...displaying processed images with overlay from the Datacube. We control the Contraves table using a GPIB interface on the SUN. GPIB also interfaces a
The Data Acquisition System for the AAO 2-Degree Field Project

NASA Astrophysics Data System (ADS)

Shortridge, K.; Farrell, T. J.; Bailey, J. A.

1993-01-01

The software system being produced by AAO to control the new 2-degree field fibre positioner and spectrographs is described. The system has to mesh cleanly with the ADAM systems used at AAO for CCD data acquisition, and has to run on a network of disparate machines including VMS Vaxes, UNIX workstations, and VME systems running VxWorks. The basis of the new system is a task control layer that operates by sending self-defining hierarchically-structured and machine-independent messages.
Kinematic principles of primate rotational vestibulo-ocular reflex. I. Spatial organization of fast phase velocity axes

NASA Technical Reports Server (NTRS)

Hess, B. J.; Angelaki, D. E.

1997-01-01

The spatial organization of fast phase velocity vectors of the vestibulo-ocular reflex (VOR) was studied in rhesus monkeys during yaw rotations about an earth-horizontal axis that changed continuously the orientation of the head relative to gravity ("barbecue spit" rotation). In addition to a velocity component parallel to the rotation axis, fast phases also exhibited a velocity component that invariably was oriented along the momentary direction of gravity. As the head rotated through supine and prone positions, torsional components of fast phase velocity axes became prominent. Similarly, as the head rotated through left and right ear-down positions, fast phase velocity axes exhibited prominent vertical components. The larger the speed of head rotation the greater the magnitude of this fast phase component, which was collinear with gravity. The main sequence properties of VOR fast phases were independent of head position. However, peak amplitude as well as peak velocity of fast phases were both modulated as a function of head orientation, exhibiting a minimum in prone position. The results suggest that the fast phases of vestibulo-ocular reflexes not only redirect gaze and reposition the eye in the direction of head motion but also reorient the eye with respect to earth-vertical when the head moves relative to gravity. As further elaborated in the companion paper, the underlying mechanism could be described as a dynamic, gravity-dependent modulation of the coordinates of ocular rotations relative to the head.
White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila

PubMed Central

2017-01-01

Increasing evidence indicates that the white (w) gene in Drosophila possesses extra-retinal functions in addition to its classical role in eye pigmentation. We have previously shown that w+ promotes fast and consistent locomotor recovery from anoxia, but how w+ modulates locomotor recovery is largely unknown. Here we show that in the absence of w+, several PDE mutants, especially cyclic guanosine monophosphate (cGMP)-specific PDE mutants, display wildtype-like fast locomotor recovery from anoxia, and that during the night time, locomotor recovery was light-sensitive in white-eyed mutant w1118, and light-insensitive in PDE mutants under w1118 background. Data indicate the involvement of cGMP in the modulation of recovery timing and presumably, light-evoked cGMP fluctuation is associated with light sensitivity of locomotor recovery. This was further supported by the observations that w-RNAi-induced delay of locomotor recovery was completely eliminated by upregulation of cGMP through multiple approaches, including PDE mutation, simultaneous overexpression of an atypical soluble guanylyl cyclase Gyc88E, or sildenafil feeding. Lastly, prolonged sildenafil feeding promoted fast locomotor recovery from anoxia in w1118. Taken together, these data suggest that a White-cGMP interaction modulates the timing of locomotor recovery from anoxia. PMID:28060942
Fast-Cycle Curriculum Development Strategies for E-Business Programs: The Bentley College Experience.

ERIC Educational Resources Information Center

Fedorowicz, Jane; Gogan, Janis L.

2001-01-01

Presents two types of fast-cycle curriculum development processes: research driven and stakeholder driven. Illustrates their application in the Bentley College business school's new course modules, elective courses, and graduate program on electronic commerce. (Contains 19 references.) (SK)
Assessing the Role of Place and Timing Cues in Coding Frequency and Amplitude Modulation as a Function of Age.

PubMed

Whiteford, Kelly L; Kreft, Heather A; Oxenham, Andrew J

2017-08-01

Natural sounds can be characterized by their fluctuations in amplitude and frequency. Ageing may affect sensitivity to some forms of fluctuations more than others. The present study used individual differences across a wide age range (20-79 years) to test the hypothesis that slow-rate, low-carrier frequency modulation (FM) is coded by phase-locked auditory-nerve responses to temporal fine structure (TFS), whereas fast-rate FM is coded via rate-place (tonotopic) cues, based on amplitude modulation (AM) of the temporal envelope after cochlear filtering. Using a low (500 Hz) carrier frequency, diotic FM and AM detection thresholds were measured at slow (1 Hz) and fast (20 Hz) rates in 85 listeners. Frequency selectivity and TFS coding were assessed using forward masking patterns and interaural phase disparity tasks (slow dichotic FM), respectively. Comparable interaural level disparity tasks (slow and fast dichotic AM and fast dichotic FM) were measured to control for effects of binaural processing not specifically related to TFS coding. Thresholds in FM and AM tasks were correlated, even across tasks thought to use separate peripheral codes. Age was correlated with slow and fast FM thresholds in both diotic and dichotic conditions. The relationship between age and AM thresholds was generally not significant. Once accounting for AM sensitivity, only diotic slow-rate FM thresholds remained significantly correlated with age. Overall, results indicate stronger effects of age on FM than AM. However, because of similar effects for both slow and fast FM when not accounting for AM sensitivity, the effects cannot be unambiguously ascribed to TFS coding.
A Solid-State Modulator for High Speed Kickers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J A; Cook, E G; Chen, Y J

2001-06-11

An all solid-state modulator with multi-pulse burst capability, very fast rise and fall times, pulse width agility, and amplitude modulation capability for use with high-speed beam kickers has been designed and tested at LLNL. The modulator uses multiple solid-state modules stacked in an inductive-adder configuration. It provides a nominal 18kV pulse with {+-} 10% amplitude modulation on the order of several MHz, rise times on the order of 10nS, and can be configured for either positive or negative polarity. The presentation will include measured performance data.
Detection of Propagating Fast Sausage Waves through Detailed Analysis of a Zebra-pattern Fine Structure in a Solar Radio Burst

NASA Astrophysics Data System (ADS)

Kaneda, K.; Misawa, H.; Iwai, K.; Masuda, S.; Tsuchiya, F.; Katoh, Y.; Obara, T.

2018-03-01

Various magnetohydrodynamic (MHD) waves have recently been detected in the solar corona and investigated intensively in the context of coronal heating and coronal seismology. In this Letter, we report the first detection of short-period propagating fast sausage mode waves in a metric radio spectral fine structure observed with the Assembly of Metric-band Aperture Telescope and Real-time Analysis System. Analysis of Zebra patterns (ZPs) in a type-IV burst revealed a quasi-periodic modulation in the frequency separation between the adjacent stripes of the ZPs (Δf ). The observed quasi-periodic modulation had a period of 1–2 s and exhibited a characteristic negative frequency drift with a rate of 3–8 MHz s‑1. Based on the double plasma resonance model, the most accepted generation model of ZPs, the observed quasi-periodic modulation of the ZP can be interpreted in terms of fast sausage mode waves propagating upward at phase speeds of 3000–8000 km s‑1. These results provide us with new insights for probing the fine structure of coronal loops.
Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry rats.

PubMed

Negroni, Julia; Meunier, Nicolas; Monnerie, Régine; Salesse, Roland; Baly, Christine; Caillol, Monique; Congar, Patrice

2012-01-01

Neuropeptide Y (NPY) plays an important role in regulating appetite and hunger in vertebrates. In the hypothalamus, NPY stimulates food intake under the control of the nutritional status. Previous studies have shown the presence of NPY and receptors in rodent olfactory system, and suggested a neuroproliferative role. Interestingly, NPY was also shown to directly modulate olfactory responses evoked by a food-related odorant in hungry axolotls. We have recently demonstrated that another nutritional cue, insulin, modulates the odorant responses of the rat olfactory mucosa (OM). Therefore, the aim of the present study was to investigate the potential effect of NPY on rat OM responses to odorants, in relation to the animal's nutritional state. We measured the potential NPY modulation of OM responses to odorant, using electro-olfactogram (EOG) recordings, in fed and fasted adult rats. NPY application significantly and transiently increased EOG amplitudes in fasted but not in fed rats. The effects of specific NPY-receptor agonists were similarly quantified, showing that NPY operated mainly through Y1 receptors. These receptors appeared as heterogeneously expressed by olfactory neurons in the OM, and western blot analysis showed that they were overexpressed in fasted rats. These data provide the first evidence that NPY modulates the initial events of odorant detection in the rat OM. Because this modulation depends on the nutritional status of the animal, and is ascribed to NPY, the most potent orexigenic peptide in the central nervous system, it evidences a strong supplementary physiological link between olfaction and nutritional processes.

Neuropeptide Y Enhances Olfactory Mucosa Responses to Odorant in Hungry Rats

PubMed Central

Negroni, Julia; Meunier, Nicolas; Monnerie, Régine; Salesse, Roland; Baly, Christine; Caillol, Monique; Congar, Patrice

2012-01-01

Neuropeptide Y (NPY) plays an important role in regulating appetite and hunger in vertebrates. In the hypothalamus, NPY stimulates food intake under the control of the nutritional status. Previous studies have shown the presence of NPY and receptors in rodent olfactory system, and suggested a neuroproliferative role. Interestingly, NPY was also shown to directly modulate olfactory responses evoked by a food-related odorant in hungry axolotls. We have recently demonstrated that another nutritional cue, insulin, modulates the odorant responses of the rat olfactory mucosa (OM). Therefore, the aim of the present study was to investigate the potential effect of NPY on rat OM responses to odorants, in relation to the animal's nutritional state. We measured the potential NPY modulation of OM responses to odorant, using electro-olfactogram (EOG) recordings, in fed and fasted adult rats. NPY application significantly and transiently increased EOG amplitudes in fasted but not in fed rats. The effects of specific NPY-receptor agonists were similarly quantified, showing that NPY operated mainly through Y1 receptors. These receptors appeared as heterogeneously expressed by olfactory neurons in the OM, and western blot analysis showed that they were overexpressed in fasted rats. These data provide the first evidence that NPY modulates the initial events of odorant detection in the rat OM. Because this modulation depends on the nutritional status of the animal, and is ascribed to NPY, the most potent orexigenic peptide in the central nervous system, it evidences a strong supplementary physiological link between olfaction and nutritional processes. PMID:23024812
Design of the Trigger Interface and Distribution Board for CEBAF 12 GeV Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gu, Jianhui; Dong, Hai; Cuevas, R

The design of the Trigger Interface and Distribution (TID) board for the 12 GeV Upgrade at the Continuous Electron Beam Accelerator Facility (CEBAF) at TJNAL is described. The TID board distributes a low jitter system clock, synchronized trigger, and synchronized multi-purpose SYNC signal. The TID also initiates data acquisition for the crate. With the TID boards, a multi-crate system can be setup for experiment test and commissioning. The TID board can be selectively populated as a Trigger Interface (TI) board, or a Trigger Distribution (TD) board for the 12 GeV upgrade experiments. When the TID is populated as a TI,more » it can be located in the VXS crate and distribute the CLOCK/TRIGGER/SYNC through the VXS P0 connector; it can also be located in the standard VME64 crate, and distribute the CLOCK/TRIGGER/SYNC through the VME P2 connector or front panel. It initiates the data acquisition for the front crate where the TI is positioned in. When the TID is populated as a TD, it fans out the CLOCK/TRIGGER/SYNC from trigger supervisor to the front end crates through optical fibres. The TD monitors the trigger processing on the TIs, and gives feedback to the TS for trigger flow control. Field Programmable Gate Arrays (FPGA) is utilised on TID board to provide programmability. The TID boards were intensively tested on the bench, and various setups.« less
Reciprocal Modulation of IK1–INa Extends Excitability in Cardiac Ventricular Cells

PubMed Central

Varghese, Anthony

2016-01-01

The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes. An increase in the expression of channels responsible for one of these two currents results in a corresponding increase in expression of the other. These currents are critical in the propagation of action potentials (AP) during the normal functioning of the heart. This study identifies a physiological role for IK1–INa reciprocal modulation in ventricular fiber activation thresholds and conduction. Simulations of action potentials in single cells and propagating APs in cardiac fibers were carried out using an existing model of electrical activity in cardiac ventricular myocytes. The conductances, GK1, of the inwardly rectifying potassium current, and GNa, of the fast inward sodium current were modified independently and in tandem to simulate reciprocal modulation. In single cells, independent modulation of GK1 alone resulted in changes in activation thresholds that were qualitatively similar to those for reciprocal GK1–GNa modulation and unlike those due to independent modulation of GNa alone, indicating that GK1 determines the cellular activation threshold. On the other hand, the variations in conduction velocity in cardiac cell fibers were similar for independent GNa modulation and for tandem changes in GK1–GNa, suggesting that GNa is primarily responsible for setting tissue AP conduction velocity. Conduction velocity dependence on GK1–GNa is significantly affected by the intercellular gap junction conductance. While the effects on the passive fiber space constant due to changes in both GK1 and the intercellular gap junction conductance, Ggj, were in line with linear cable theory predictions, both conductances had surprisingly large effects on fiber activation thresholds. Independent modulation of GK1 rendered cardiac fibers inexcitable at higher levels of GK1 whereas tandem GK1–GNa changes allowed fibers to remain excitable at high GK1 values. Reciprocal modulation of the inwardly rectifying potassium current and the fast inward sodium current may have a functional role in allowing cardiac tissue to remain excitable when IK1 is upregulated. PMID:27895596
Test results of 3.7 GHz 500kW CW klystron for SST1 LHCD system

NASA Astrophysics Data System (ADS)

Sharma, Promod Kumar; Ambulkar, Kiran K.; Dalakoti, Shefali; Rajan Babu, N.; Parmar, Pramod R.; Virani, Chetan G.; Thakur, Arvind L.

2012-10-01

A 3.7 GHz, LHCD system aims to driving non inductive plasma current for SST1 machine. Its capability has been enhanced up to 2 MW by adding two additional klystrons, each rated for 500kW, CW power. The additional klystrons are installed and commissioned at site, for rated power, for more than 1000 seconds, before connecting them to main LHCD system. The auxiliary systems, like supporting power supply system (magnet, filament, ion pump, etc.), active heat management system, slow and fast interlock system, transmission line pressurization system, low power rf drive system, etc. are inter-connected with klystron system through VME based data acquisition and control system for remote CW operation of klystron at rated power. The calorimetric measurements, employing Pt-100 sensors, suggests that the maximum rf power (˜500kW CW) extracted from klystron is dissipated on water cooled dummy loads. The unspent DC power (˜800 kW CW) is dissipated in collector which is heavily cooled with water flowing at ˜1300 litres/min (lpm). The power loss in the klystron body remained within 20 kW. The cavity temperature, measured using J-type thermocouple, remained below 150 ^oC. The output rf power, sampled through directional couplers and measured by rf detectors shows good agreement with calorimetric measurements. A detailed description of the klystron test set up and the test results obtained during its commissioning is presented in this paper.
Reactor Statics Module, RS-9: Multigroup Diffusion Program Using an Exponential Acceleration Technique.

ERIC Educational Resources Information Center

Macek, Victor C.

The nine Reactor Statics Modules are designed to introduce students to the use of numerical methods and digital computers for calculation of neutron flux distributions in space and energy which are needed to calculate criticality, power distribution, and fuel burnup for both slow neutron and fast neutron fission reactors. The last module, RS-9,…
Fast-response and scattering-free polymer network liquid crystals for infrared light modulators

NASA Astrophysics Data System (ADS)

Fan, Yun-Hsing; Lin, Yi-Hsin; Ren, Hongwen; Gauza, Sebastian; Wu, Shin-Tson

2004-02-01

A fast-response and scattering-free homogeneously aligned polymer network liquid crystal (PNLC) light modulator is demonstrated at λ=1.55 μm wavelength. Light scattering in the near-infrared region is suppressed by optimizing the polymer concentration such that the network domain sizes are smaller than the wavelength. The strong polymer network anchoring assists LC to relax back quickly as the electric field is removed. As a result, the PNLC response time is ˜250× faster than that of the E44 LC mixture except that the threshold voltage is increased by ˜25×.
Apparatus for continuous, fast, and precise measurements of position and velocity of a small spherical particle

NASA Technical Reports Server (NTRS)

Venkataraman, T. S.; Eidson, W. W.; Cohen, L. D.; Farina, J. D.; Acquista, C.

1983-01-01

The position and velocity of optically levitated glass spheres (radii 10-20 microns) movng in a gas are measured accurately, rapidly, and continuously using a high-speed rotating polygon mirror. The experimental technique developed here has repeatable position accuracies better than 20 microns. Each measurement takes less than 1 microsec and can be repeated every 100 microsec. The position of the levitated glass spheres can be manipulated accurately by modulating the laser power with an acoustic optic modulator. The technique provides a fast and accurate method to study general particle dynamics in a fluid.
Reusable Rack Interface Controller Common Software for Various Science Research Racks on the International Space Station

NASA Technical Reports Server (NTRS)

Lu, George C.

2003-01-01

The purpose of the EXPRESS (Expedite the PRocessing of Experiments to Space Station) rack project is to provide a set of predefined interfaces for scientific payloads which allow rapid integration into a payload rack on International Space Station (ISS). VxWorks' was selected as the operating system for the rack and payload resource controller, primarily based on the proliferation of VME (Versa Module Eurocard) products. These products provide needed flexibility for future hardware upgrades to meet everchanging science research rack configuration requirements. On the International Space Station, there are multiple science research rack configurations, including: 1) Human Research Facility (HRF); 2) EXPRESS ARIS (Active Rack Isolation System); 3) WORF (Window Observational Research Facility); and 4) HHR (Habitat Holding Rack). The RIC (Rack Interface Controller) connects payloads to the ISS bus architecture for data transfer between the payload and ground control. The RIC is a general purpose embedded computer which supports multiple communication protocols, including fiber optic communication buses, Ethernet buses, EIA-422, Mil-Std-1553 buses, SMPTE (Society Motion Picture Television Engineers)-170M video, and audio interfaces to payloads and the ISS. As a cost saving and software reliability strategy, the Boeing Payload Software Organization developed reusable common software where appropriate. These reusable modules included a set of low-level driver software interfaces to 1553B. RS232, RS422, Ethernet buses, HRDL (High Rate Data Link), video switch functionality, telemetry processing, and executive software hosted on the FUC computer. These drivers formed the basis for software development of the HRF, EXPRESS, EXPRESS ARIS, WORF, and HHR RIC executable modules. The reusable RIC common software has provided extensive benefits, including: 1) Significant reduction in development flow time; 2) Minimal rework and maintenance; 3) Improved reliability; and 4) Overall reduction in software life cycle cost. Due to the limited number of crew hours available on ISS for science research, operational efficiency is a critical customer concern. The current method of upgrading RIC software is a time consuming process; thus, an improved methodology for uploading RIC software is currently under evaluation.
Fast myopic 2D-SIM super resolution microscopy with joint modulation pattern estimation

NASA Astrophysics Data System (ADS)

Orieux, François; Loriette, Vincent; Olivo-Marin, Jean-Christophe; Sepulveda, Eduardo; Fragola, Alexandra

2017-12-01

Super-resolution in structured illumination microscopy (SIM) is obtained through de-aliasing of modulated raw images, in which high frequencies are measured indirectly inside the optical transfer function. Usual approaches that use 9 or 15 images are often too slow for dynamic studies. Moreover, as experimental conditions change with time, modulation parameters must be estimated within the images. This paper tackles the problem of image reconstruction for fast super resolution in SIM, where the number of available raw images is reduced to four instead of nine or fifteen. Within an optimization framework, the solution is inferred via a joint myopic criterion for image and modulation (or acquisition) parameters, leading to what is frequently called a myopic or semi-blind inversion problem. The estimate is chosen as the minimizer of the nonlinear criterion, numerically calculated by means of a block coordinate optimization algorithm. The effectiveness of the proposed method is demonstrated for simulated and experimental examples. The results show precise estimation of the modulation parameters jointly with the reconstruction of the super resolution image. The method also shows its effectiveness for thick biological samples.
α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations

PubMed Central

Heistek, Tim S; Ruiperez-Alonso, Marta; Timmerman, A Jaap; Brussaard, Arjen B; Mansvelder, Huibert D

2013-01-01

GABAA receptors are critically involved in hippocampal oscillations. GABAA receptor α1 and α2 subunits are differentially expressed throughout the hippocampal circuitry and thereby may have distinct contributions to oscillations. It is unknown which GABAA receptor α subunit controls hippocampal oscillations and where these receptors are expressed. To address these questions we used transgenic mice expressing GABAA receptor α1 and/or α2 subunits with point mutations (H101R) that render these receptors insensitive to allosteric modulation at the benzodiazepine binding site, and tested how increased or decreased function of α subunits affects hippocampal oscillations. Positive allosteric modulation by zolpidem prolonged decay kinetics of hippocampal GABAergic synaptic transmission and reduced the frequency of cholinergically induced oscillations. Allosteric modulation of GABAergic receptors in CA3 altered oscillation frequency in CA1, while modulation of GABA receptors in CA1 did not affect oscillations. In mice having a point mutation (H101R) at the GABAA receptor α2 subunit, zolpidem effects on cholinergically induced oscillations were strongly reduced compared to wild-type animals, while zolpidem modulation was still present in mice with the H101R mutation at the α1 subunit. Furthermore, genetic knockout of α2 subunits strongly reduced oscillations, whereas knockout of α1 subunits had no effect. Allosteric modulation of GABAergic receptors was strongly reduced in unitary connections between fast spiking interneurons and pyramidal neurons in CA3 of α2H101R mice, but not of α1H101R mice, suggesting that fast spiking interneuron to pyramidal neuron synapses in CA3 contain α2 subunits. These findings suggest that α2-containing GABAA receptors expressed in the CA3 region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations. PMID:23109109
The performance of the γ-ray tracking array GRETINA for γ-ray spectroscopy with fast beams of rare isotopes

DOE PAGES

Weisshaar, D.; Bazin, D.; Bender, P. C.; ...

2016-12-03

The gamma-ray tracking array GRETINA was coupled to the S800 magnetic spectrometer for spectroscopy with fast beams of rare isotopes at the National Superconducting Cyclotron Laboratory on the campus of Michigan State University. We describe the technical details of this powerful setup and report on GRETINA's performance achieved with source and in-beam measurements. The gamma-ray multiplicity encountered in experiments with fast beams is usually low, allowing for a simplified and efficient treatment of the data in the gamma-ray analysis in terms of Doppler reconstruction and spectral quality. Finally, the results reported in this work were obtained from GRETINA consisting ofmore » 8 detector modules hosting four high-purity germanium crystals each. Currently, GRETINA consists of 10 detector modules.« less
Artificial intelligence applications of fast optical memory access

NASA Astrophysics Data System (ADS)

Henshaw, P. D.; Todtenkopf, A. B.

The operating principles and performance of rapid laser beam-steering (LBS) techniques are reviewed and illustrated with diagrams; their applicability to fast optical-memory (disk) access is evaluated; and the implications of fast access for the design of expert systems are discussed. LBS methods examined include analog deflection (source motion, wavefront tilt, and phased arrays), digital deflection (polarization modulation, reflectivity modulation, interferometric switching, and waveguide deflection), and photorefractive LBS. The disk-access problem is considered, and typical LBS requirements are listed as 38,000 beam positions, rotational latency 25 ms, one-sector rotation time 1.5 ms, and intersector space 87 microsec. The value of rapid access for increasing the power of expert systems (by permitting better organization of blocks of information) is illustrated by summarizing the learning process of the MVP-FORTH system (Park, 1983).
Submillisecond-response polymer network liquid crystal phase modulators at 1.06-μm wavelength

NASA Astrophysics Data System (ADS)

Sun, Jie; Xianyu, Haiqing; Chen, Yuan; Wu, Shin-Tson

2011-07-01

A fast-response and scattering-free polymer network liquid crystal (PNLC) light modulator is demonstrated at λ = 1.06 μm wavelength. A decay time of 117 μs for 2π phase modulation is obtained at 70 °C, which is ˜ 650 × faster than that of the host nematic LCs. The major tradeoff is the increased operating voltage. Potential applications include spatial light modulators and adaptive optics.
Applying High-Speed Vision Sensing to an Industrial Robot for High-Performance Position Regulation under Uncertainties

PubMed Central

Huang, Shouren; Bergström, Niklas; Yamakawa, Yuji; Senoo, Taku; Ishikawa, Masatoshi

2016-01-01

It is traditionally difficult to implement fast and accurate position regulation on an industrial robot in the presence of uncertainties. The uncertain factors can be attributed either to the industrial robot itself (e.g., a mismatch of dynamics, mechanical defects such as backlash, etc.) or to the external environment (e.g., calibration errors, misalignment or perturbations of a workpiece, etc.). This paper proposes a systematic approach to implement high-performance position regulation under uncertainties on a general industrial robot (referred to as the main robot) with minimal or no manual teaching. The method is based on a coarse-to-fine strategy that involves configuring an add-on module for the main robot’s end effector. The add-on module consists of a 1000 Hz vision sensor and a high-speed actuator to compensate for accumulated uncertainties. The main robot only focuses on fast and coarse motion, with its trajectories automatically planned by image information from a static low-cost camera. Fast and accurate peg-and-hole alignment in one dimension was implemented as an application scenario by using a commercial parallel-link robot and an add-on compensation module with one degree of freedom (DoF). Experimental results yielded an almost 100% success rate for fast peg-in-hole manipulation (with regulation accuracy at about 0.1 mm) when the workpiece was randomly placed. PMID:27483274
Timing of Locomotor Recovery from Anoxia Modulated by the white Gene in Drosophila

PubMed Central

Xiao, Chengfeng; Robertson, R. Meldrum

2016-01-01

Locomotor recovery from anoxia follows the restoration of disordered ion distributions and neuronal excitability. The time taken for locomotor recovery after 30 sec anoxia (around 10 min) is longer than the time for the propagation of action potentials to be restored (<1 min) in Drosophila wild type. We report here that the white (w) gene modulates the timing of locomotor recovery. Wild-type flies displayed fast and consistent recovery of locomotion from anoxia, whereas mutants of w showed significantly delayed and more variable recovery. Genetic analysis including serial backcrossing revealed a strong association between the w locus and the timing of locomotor recovery, and haplo-insufficient function of w+ in promoting fast recovery. The locomotor recovery phenotype was independent of classic eye pigmentation, although both are associated with the w gene. Introducing up to four copies of mini-white (mw+) into w1118 was insufficient to promote fast and consistent locomotor recovery. However, flies carrying w+ duplicated to the Y chromosome showed wild-type-like fast locomotor recovery. Furthermore, Knockdown of w by RNA interference (RNAi) in neurons but not glia delayed locomotor recovery, and specifically, knockdown of w in subsets of serotonin neurons was sufficient to delay the locomotor recovery. These data reveal an additional role for w in modulating the timing of locomotor recovery from anoxia. PMID:27029736
High power fast wave experiments in LAPD: interaction with density fluctuations and status/plans for ICRH

NASA Astrophysics Data System (ADS)

Carter, Troy; Martin, Michael; van Compernolle, Bart; Gekelman, Walter; Pribyl, Pat; Vincena, Stephen; Tripathi, Shreekrishna; van Eester, Dirk; Crombe, Kristel

2016-10-01

The LArge Plasma Device (LAPD) at UCLA is a 17 m long, up to 60 cm diameter magnetized plasma column with typical plasma parameters ne 1012 -1013 cm-3, Te 1 - 10 eV, and B 1 kG. A new high-power ( 200 kW) RF system and antenna has been developed for LAPD, enabling the generation of large amplitude fast waves in LAPD. Interaction between the fast waves and density fluctuations is observed, resulting in modulation of the coupled RF power. Two classes of RF-induced density fluctuations are observed. First, a coherent (10 kHz) oscillation is observed spatially near the antenna in response to the initial RF turn-on transient. Second, broadband density fluctuations are enhanced when the RF power is above a threshold a threshold. Strong modulation of the fast wave magnetic fluctuations is observed along with broadening of the primary RF spectral line. Ultimately, high power fast waves will be used for ion heating in LAPD through minority species fundamental heating or second harmonic minority or majority heating. Initial experimental results from heating experiments will be presented along with a discussion of future plans. BaPSF supported by NSF and DOE.
Molecular oxygen detection using frequency modulation diode laser spectroscopy

NASA Technical Reports Server (NTRS)

Wang, Liang-Guo; Sachse, Glen

1990-01-01

A high-sensitivity spectroscopic measurement of O2 using two-tone frequency modulation spectroscopy with a GaAlAs diode laser is presented. An oxygen sensor based on this technique would be non-intrusive, compact and possess high sensitivity and fast time response.
Fast global orbit feedback system in PLS-II

NASA Astrophysics Data System (ADS)

Lee, J.; Kim, C.; Kim, J. M.; Kim, K. R.; Lee, E. H.; Lee, J. W.; Lee, T. Y.; Park, C. D.; Shin, S.; Yoon, J. C.; Cho, W. S.; Park, G. S.; Kim, S. C.

2016-12-01

The transverse position of the electron beam in the Pohang Light Source-II is stabilized by the global orbit feedback system. A slow orbit feedback system has been operating at 2 Hz, and a fast orbit feedback (FOFB) system at 813 Hz was installed recently. This FOFB system consists of 96 electron-beam-position monitors, 48 horizontal fast correctors, 48 vertical fast correctors and Versa Module Europa bus control system. We present the design and implementation of the FOFB system and its test result. Simulation analysis is presented and future improvements are suggested.
The Quantum Dynamics of Chemical Reactions.

DTIC Science & Technology

1983-03-31

of the potential formed by taking a cut perpendicular to the minimum energy path (in Delves coordinates) V (s) = VmeP(s) + Ev(S) (5) ve sn where s is...current density and profiles of the component of jo normal to various straight-line cuts along the streamline field, for the H + H2(0) - H 2 + H...In order to visualize the nature of this topology, we display in Fig. 31 cuts of the equipotentials of V by the XZ. (y. - 0, x) and Y.Z, (’. - n/2, -x
Telemetry Technology

NASA Technical Reports Server (NTRS)

1997-01-01

In 1990, Avtec Systems, Inc. developed its first telemetry boards for Goddard Space Flight Center. Avtec products now include PC/AT, PCI and VME-based high speed I/O boards and turn-key systems. The most recent and most successful technology transfer from NASA to Avtec is the Programmable Telemetry Processor (PTP), a personal computer- based, multi-channel telemetry front-end processing system originally developed to support the NASA communication (NASCOM) network. The PTP performs data acquisition, real-time network transfer, and store and forward operations. There are over 100 PTP systems located in NASA facilities and throughout the world.

Molecular Electronic Devices Based On Electrooptical Behavior Of Heme-Like Molecules

NASA Astrophysics Data System (ADS)

Simic-Glavaski, B.

1986-02-01

This paper discusses application of the electrically modulated and unusually strong Raman emitted light produced by an adsorbed monolayer of phthalocyanine molecules on silver electrode or silver bromide substrates and on neural membranes. The analysis of electronic energy levels in semiconducting silver bromide and the adsorbed phthalocyanine molecules suggests a lasing mechanism as a possible origin of the high enhancement factor in surface enhanced Raman scattering. Electrically modulated Raman scattering may be used as a carrier of information which is drawn fran the fast intramolecular electron transfer aN,the multiplicity of quantum wells in phthalocyanine molecules. Fast switching times on the order of 10-13 seconds have been measured at room temperature. Multilevel and multioutput optical signals have also been obtained fran such an electrically modulated adsorbed monolayer of phthalocyanine molecules which can be precisely addressed and interrogated. This may be of practical use to develop Nlecular electronic devices with high density memory and fast parallel processing systems with a typical 1020 gate Hz/cm2 capacity at room temperature for use in optical computers. The paper also discusses the electrooptical modulation of Raman signals obtained from adsorbed bio-compatible phthalocyanine molecules on nerve membranes. This optical probe of neural systems can be used in studies of complex information processing in neural nets and provides a possible method for interfacing natural and man-made information processing devices.
Gain-switching characteristics and fast transient response of three-terminal size-effect modulation laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suemune, I.; Takeoka, T.; Yamanashi, M.

1986-09-01

Gain-switching characteristics of the proposed size-effect modulation light sources are investigated. For realizing the laser operation, the consideration of the screening effect on the applied electric fields due to the high concentration of carriers is indispensable. In this respect, the authors propose a separate-confinement-hereto-multiple-quantum-well (SCH-MQW) structure as the most suitable one for gain switching. The key point of the structure is the sufficiently high heterobarriers at the clad-barrier interfaces to prevent carrier leakage. The examinations of the transient response clarify that they are principally photon-lifetime limited. Employing the three-terminal character of the proposed laser, the fast pulse modulation up tomore » 12 Gbits/s, which is almost free from the relaxation oscillations and the pattern effects, is predicted.« less
A Walsh Function Module Users' Manual

NASA Technical Reports Server (NTRS)

Gnoffo, Peter A.

2014-01-01

The solution of partial differential equations (PDEs) with Walsh functions offers new opportunities to simulate many challenging problems in mathematical physics. The approach was developed to better simulate hypersonic flows with shocks on unstructured grids. It is unique in that integrals and derivatives are computed using simple matrix multiplication of series representations of functions without the need for divided differences. The product of any two Walsh functions is another Walsh function - a feature that radically changes an algorithm for solving PDEs. A FORTRAN module for supporting Walsh function simulations is documented. A FORTRAN code is also documented with options for solving time-dependent problems: an advection equation, a Burgers equation, and a Riemann problem. The sample problems demonstrate the usage of the Walsh function module including such features as operator overloading, Fast Walsh Transforms in multi-dimensions, and a Fast Walsh reciprocal.
Fast-response IR spatial light modulators with a polymer network liquid crystal

NASA Astrophysics Data System (ADS)

Peng, Fenglin; Chen, Haiwei; Tripathi, Suvagata; Twieg, Robert J.; Wu, Shin-Tson

2015-03-01

Liquid crystals (LC) have widespread applications for amplitude modulation (e.g. flat panel displays) and phase modulation (e.g. beam steering). For phase modulation, a 2π phase modulo is required. To extend the electro-optic application into infrared region (MWIR and LWIR), several key technical challenges have to be overcome: 1. low absorption loss, 2. high birefringence, 3. low operation voltage, and 4. fast response time. After three decades of extensive development, an increasing number of IR devices adopting LC technology have been demonstrated, such as liquid crystal waveguide, laser beam steering at 1.55μm and 10.6 μm, spatial light modulator in the MWIR (3~5μm) band, dynamic scene projectors for infrared seekers in the LWIR (8~12μm) band. However, several fundamental molecular vibration bands and overtones exist in the MWIR and LWIR regions, which contribute to high absorption coefficient and hinder its widespread application. Therefore, the inherent absorption loss becomes a major concern for IR devices. To suppress IR absorption, several approaches have been investigated: 1) Employing thin cell gap by choosing a high birefringence liquid crystal mixture; 2) Shifting the absorption bands outside the spectral region of interest by deuteration, fluorination and chlorination; 3) Reducing the overlap vibration bands by using shorter alkyl chain compounds. In this paper, we report some chlorinated LC compounds and mixtures with a low absorption loss in the near infrared and MWIR regions. To achieve fast response time, we have demonstrated a polymer network liquid crystal with 2π phase change at MWIR and response time less than 5 ms.
The EUCLID/V1 Integrated Code for Safety Assessment of Liquid Metal Cooled Fast Reactors. Part 1: Basic Models

NASA Astrophysics Data System (ADS)

Mosunova, N. A.

2018-05-01

The article describes the basic models included in the EUCLID/V1 integrated code intended for safety analysis of liquid metal (sodium, lead, and lead-bismuth) cooled fast reactors using fuel rods with a gas gap and pellet dioxide, mixed oxide or nitride uranium-plutonium fuel under normal operation, under anticipated operational occurrences and accident conditions by carrying out interconnected thermal-hydraulic, neutronics, and thermal-mechanical calculations. Information about the Russian and foreign analogs of the EUCLID/V1 integrated code is given. Modeled objects, equation systems in differential form solved in each module of the EUCLID/V1 integrated code (the thermal-hydraulic, neutronics, fuel rod analysis module, and the burnup and decay heat calculation modules), the main calculated quantities, and also the limitations on application of the code are presented. The article also gives data on the scope of functions performed by the integrated code's thermal-hydraulic module, using which it is possible to describe both one- and twophase processes occurring in the coolant. It is shown that, owing to the availability of the fuel rod analysis module in the integrated code, it becomes possible to estimate the performance of fuel rods in different regimes of the reactor operation. It is also shown that the models implemented in the code for calculating neutron-physical processes make it possible to take into account the neutron field distribution over the fuel assembly cross section as well as other features important for the safety assessment of fast reactors.
Demonstration of pulse controlled all-optical switch/modulator.

PubMed

Akin, Osman; Dinleyici, M S

2014-03-15

An all-optical pulse controlled switch/modulator based on evanescent coupling between a polymer slab waveguide and a single mode fiber is demonstrated. Very fast all-optical modulation/switching is achieved via Kerr effect of the nonlinear polymer placed in the evanescent region of the optical fiber. Local refractive index perturbation (Δn=-1.45612×10(-5)) on the thin film leads to 0.374 nW power modulation at the fiber output, which results in a switching efficiency of ≈1.5%.
Intermittent fasting modulates IgA levels in the small intestine under intense stress: a mouse model.

PubMed

Lara-Padilla, Eleazar; Godínez-Victoria, Marycarmen; Drago-Serrano, Maria Elisa; Reyna-Garfias, Humberto; Arciniega-Martínez, Ivonne Maciel; Abarca-Rojano, Edgar; Cruz-Hernández, Teresita Rocío; Campos-Rodríguez, Rafael

2015-08-15

Intermittent fasting prolongs the lifespan and unlike intense stress provides health benefits. Given the role of the immunoglobulin A (IgA) in the intestinal homeostasis, the aim of this study was to assess the impact of intermittent fasting plus intense stress on secretory IgA (SIgA) production and other mucosal parameters in the duodenum and ileum. Two groups of six mice, with intermittent fasting or fed ad libitum for 12weeks, were submitted to a session of intense stress by a bout of forced swimming. Unstressed ad libitum fed or intermittently fasted groups were included as controls. After sacrifice, we evaluated intestinal SIgA and plasma adrenal hormones, lamina propria IgA+ plasma-cells, mRNA expression of polymeric immunoglobulin receptor, α- and J-chains in the liver and intestinal mucosa, as well as pro- (tumor necrosis factor-α, interleukin-6 and Interferon-γ) and anti- (interleukin-2, -4, -10 and transforming growth factor-β) inflammatory cytokines in mucosal samples. Under intense stress, intermittent fasting down- or up-modulated the levels of most parameters in the duodenum and ileum, respectively while up-regulated corticosterone levels without affecting epinephrine. Our data suggest intermittent fasting plus intense stress elicited neuroendocrine pathways that differentially controlled IgA and pIgR expression in duodenum and ileum. These findings provide experimental foundations for a presumable impact of intermittent fasting under intense stress on the intestinal homeostasis or inflammation by triggering or reducing the IgA production in ileum or duodenum respectively. Copyright © 2015 Elsevier B.V. All rights reserved.
The Functional Arm Scale for Throwers (FAST)-Part I: The Design and Development of an Upper Extremity Region-Specific and Population-Specific Patient-Reported Outcome Scale for Throwing Athletes.

PubMed

Sauers, Eric L; Bay, R Curtis; Snyder Valier, Alison R; Ellery, Traci; Huxel Bliven, Kellie C

2017-03-01

Upper extremity (UE) region-specific, patient-reported outcome (PRO) scales assess injuries to the UE but do not account for the demands of overhead throwing athletes or measure patient-oriented domains of health-related quality of life (HRQOL). To develop the Functional Arm Scale for Throwers (FAST), a UE region-specific and population-specific PRO scale that assesses multiple domains of disablement in throwing athletes with UE injuries. In stage I, a beta version of the scale was developed for subsequent factor identification, final item reduction, and construct validity analysis during stage II. Descriptive laboratory study. Three-stage scale development was utilized: Stage I (item generation and initial item reduction) and stage II (factor analysis, final item reduction, and construct validity) are reported herein, and stage III (establishment of measurement properties [reliability and validity]) will be reported in a companion paper. In stage I, a beta version was developed, incorporating National Center for Medical Rehabilitation Research disablement domains and ensuring a blend of sport-related and non-sport-related items. An expert panel and focus group assessed importance and interpretability of each item. During stage II, the FAST was reduced, preserving variance characteristics and factor structure of the beta version and construct validity of the final FAST scale. During stage I, a 54-item beta version and a separate 9-item pitcher module were developed. During stage II, a 22-item FAST and 9-item pitcher module were finalized. The factor solution for FAST scale items included pain (n = 6), throwing (n = 10), activities of daily living (n = 5), psychological impact (n = 4), and advancement (n = 3). The 6-item pain subscale crossed factors. The remaining subscales and pitcher module are distinctive, correlated, and internally consistent and may be interpreted individually or combined. This article describes the development of the FAST, which assesses clinical outcomes and HRQOL of throwing athletes after UE injury. The FAST encompasses multiple domains of disability and demonstrates excellent construct validity. The FAST provides a single UE region-specific and population-specific PRO scale for high-demand throwers to facilitate measurement of impact of UE injuries on HRQOL and clinical outcomes while quantifying recovery for comparative effectiveness studies.
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting.

PubMed

Heemstra, Karen A; Soeters, Maarten R; Fliers, Eric; Serlie, Mireille J; Burggraaf, Jacobus; van Doorn, Martijn B; van der Klaauw, Agatha A; Romijn, Johannes A; Smit, Johannes W; Corssmit, Eleonora P; Visser, Theo J

2009-06-01

The iodothyronine deiodinases D1, D2, and D3 enable tissue-specific adaptation of thyroid hormone levels in response to various conditions, such as hypothyroidism or fasting. The possible expression of D2 mRNA in skeletal muscle is intriguing because this enzyme could play a role in systemic as well as local T3 production. We determined D2 activity and D2 mRNA expression in human skeletal muscle biopsies under control conditions and during hypothyroidism, fasting, and hyperinsulinemia. This was a prospective study. The study was conducted at a university hospital. We studied 11 thyroidectomized patients with differentiated thyroid carcinoma (DTC) on and after 4 wk off T4( replacement and six healthy lean subjects in the fasting state and during hyperinsulinemia after both 14 and 62 h of fasting. D2 activity and D2 mRNA levels were measured in skeletal muscle samples. No differences were observed in muscle D2 mRNA levels in DTC patients on and off T4 replacement therapy. In healthy subjects, muscle D2 mRNA levels were lower after 62 h compared to 14 h of fasting. Insulin increased mRNA expression after 62 h, but not after 14 h of fasting. Skeletal muscle D2 activities were very low and not influenced by hypothyroidism and fasting. Human skeletal muscle D2 mRNA expression is modulated by fasting and insulin, but not by hypothyroidism. The lack of a clear effect of D2 mRNA modulation on the observed low D2 activities questions the physiological relevance of D2 activity in human skeletal muscle.
Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice.

PubMed

Pitchaimani, Vigneshwaran; Arumugam, Somasundaram; Thandavarayan, Rajarajan Amirthalingam; Karuppagounder, Vengadeshprabhu; Afrin, Mst Rejina; Sreedhar, Remya; Harima, Meilei; Suzuki, Hiroshi; Miyashita, Shizuka; Nakamura, Takashi; Suzuki, Kenji; Nakamura, Masahiko; Ueno, Kazuyuki; Watanabe, Kenichi

2016-09-01

Fasting (48h) in mice causes resistance to insulin-induced hypoglycemic seizures (IIHS) but in rats fasting (14-16h) predisposes IIHS. So we suspect the duration of fasting may possibly affect the onset of seizures and in this study, we investigated the IIHS by administering 8 Units (U) insulin (INS)/k.g., intraperitoneally to 8 weeks old male C57BL6/J mice. The mice were divided into group 1 (non-fasted), group 2 (6h fasted) and group 3 (24h fasted) and we administered the 8U INS. The first behavioral hypoglycemic seizure symptoms such as jump, clonus or barrel rotations considered as seizure onset and we analyzed the blood glucose level (BGL) and serum beta-hydroxybutyrate (BHB) level. The time of first seizure onset in group 1 was 109.7±4.3min, group 2 was 46.50±3.9min and group 3 was 165.4±13.26min. The seizure onset time in group 2 was significantly decreased compared to group 1. The seizure onset time in group 3 was significantly increased compared to group 1 and group 2. The decreased BGL after INS administration was correlated with the seizure onset time in group 1 and group 2 but not in group 3. The BHB level in group 3 was significantly higher compared to group 1 and 2. Our data show that the fasting time duration significantly modulates the onset of hypoglycemic seizures. The opposite effect of 6h or 24h fasting time duration is likely caused by different BHB levels. Copyright © 2016 Elsevier B.V. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Bingbin; Karr, Dale G.; Song, Huimin

It is a fact that developing offshore wind energy has become more and more serious worldwide in recent years. Many of the promising offshore wind farm locations are in cold regions that may have ice cover during wintertime. The challenge of possible ice loads on offshore wind turbines raises the demand of modeling capacity of dynamic wind turbine response under the joint action of ice, wind, wave, and current. The simulation software FAST is an open source computer-aided engineering (CAE) package maintained by the National Renewable Energy Laboratory. In this paper, a new module of FAST for assessing the dynamicmore » response of offshore wind turbines subjected to ice forcing is presented. In the ice module, several models are presented which involve both prescribed forcing and coupled response. For conditions in which the ice forcing is essentially decoupled from the structural response, ice forces are established from existing models for brittle and ductile ice failure. For conditions in which the ice failure and the structural response are coupled, such as lock-in conditions, a rate-dependent ice model is described, which is developed in conjunction with a new modularization framework for FAST. In this paper, analytical ice mechanics models are presented that incorporate ice floe forcing, deformation, and failure. For lower speeds, forces slowly build until the ice strength is reached and ice fails resulting in a quasi-static condition. For intermediate speeds, the ice failure can be coupled with the structural response and resulting in coinciding periods of the ice failure and the structural response. A third regime occurs at high speeds of encounter in which brittle fracturing of the ice feature occurs in a random pattern, which results in a random vibration excitation of the structure. An example wind turbine response is simulated under ice loading of each of the presented models. This module adds to FAST the capabilities for analyzing the response of wind turbines subjected to forces resulting from ice impact on the turbine support structure. The conditions considered in this module are specifically addressed in the International Organization for Standardization (ISO) standard 19906:2010 for arctic offshore structures design consideration. Special consideration of lock-in vibrations is required due to the detrimental effects of such response with regard to fatigue and foundation/soil response. Finally, the use of FAST for transient, time domain simulation with the new ice module is well suited for such analyses.« less
Flow Modulation and Force Control in Insect Fast Maneuver

NASA Astrophysics Data System (ADS)

Li, Chengyu; Dong, Haibo; Zhang, Wen; Gai, Kuo

2012-11-01

In this work, an integrated study combining high-speed photogrammetry and direct numerical simulation (DNS) is used to study free flying insects in fast maneuver. Quantitative measurement has shown the significant differences between quad-winged flyers such as dragonfly and damselfly and two-winged flyers such as cicada. Comparisons of unsteady 3D vortex formation and associated aerodynamic force production reveal the different mechanisms used by insects in fast turn. This work is supported by NSF CBET-1055949.
Dual-tasks and walking fast: relationship to extra-pyramidal signs in advanced Alzheimer disease.

PubMed

Camicioli, Richard; Bouchard, Thomas; Licis, Lisa

2006-10-25

Extra-pyramidal signs (EPS) and cadence predicted falls risk in patients with advanced Alzheimer disease (AD). Dual task performance predicts falls with variable success. Dual-task performance and walking fast were examined in advanced AD patients with EPS (EPS+, >3 modified Unified Parkinson's Disease Rating Scale [UPDRS] signs) or without EPS (EPS-, three or less UPDRS signs). Demographics, mental and functional status, behavioral impairment, EPS, and quantitative gait measures (GaitRite) were determined. The effects of an automatic dual-task (simple counting) and of walking fast on spatial and temporal gait characteristics were compared between EPS+ and EPS- subjects using a repeated measures design. Cadence decreased, while stride time, swing time and variability in swing time increased with the dual task. Results were insignificant after adjusting for secondary task performance. With walking fast, speed, cadence and stride length increased while stride time, swing time and double support time decreased. Although EPS+ subjects were slower and had decreased stride length, dual task and walking fast effects did not differ from EPS- subjects. Patient characteristics, the type of secondary task and the specific gait measures examined vary in the literature. In this moderately to severely demented population, EPS did not affect "unconscious" (dual task) or "conscious" (walking fast) gait modulation. Given their high falls risk, and retained ability to modulate walking, EPS+ AD patients may be ideal candidates for interventions aimed at preventing falls.
FAST - A multiprocessed environment for visualization of computational fluid dynamics

NASA Technical Reports Server (NTRS)

Bancroft, Gordon V.; Merritt, Fergus J.; Plessel, Todd C.; Kelaita, Paul G.; Mccabe, R. Kevin

1991-01-01

The paper presents the Flow Analysis Software Toolset (FAST) to be used for fluid-mechanics analysis. The design criteria for FAST including the minimization of the data path in the computational fluid-dynamics (CFD) process, consistent user interface, extensible software architecture, modularization, and the isolation of three-dimensional tasks from the application programmer are outlined. Each separate process communicates through the FAST Hub, while other modules such as FAST Central, NAS file input, CFD calculator, surface extractor and renderer, titler, tracer, and isolev might work together to generate the scene. An interprocess communication package making it possible for FAST to operate as a modular environment where resources could be shared among different machines as well as a single host is discussed.
Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis).

PubMed Central

Schmidt, K F; Kruse, M; Hatt, H

1994-01-01

The patch-clamp technique in combination with a fast liquid filament application system was used to study the effect of dopamine on the glutamate receptor desensitization in horizontal cells of the perch (Perca fluviatilis). Kinetics of ligand-gated ion channels in fish horizontal cells are modulated by dopamine. This modulation is presumably mediated by a cAMP-dependent protein phosphorylation. Before incubation with dopamine, the glutamate receptors of horizontal cells activate and desensitize with fast time constants. In the whole-cell recording mode, fast application of the agonists L-glutamate, quisqualate, or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid prior to the dopamine incubation gives rise to fast transient currents with peak values of about 200 pA that desensitize within 100 ms. Kainate as agonist produced higher steady-state currents but no transient currents. After incubation of the cells with dopamine for 3 min, the desensitization was significantly reduced and the agonists L-glutamate, quisqualate, or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid induced steady-state currents with amplitudes that were similar to the previously observed transient currents. Kainate-induced currents were only slightly affected. Fast desensitizing currents upon fast application of L-glutamate were also recorded from outside-out patches that were excised from horizontal cells before incubation with dopamine. The currents from excised patches desensitized to a steady-state level of about 0.2 of the peak amplitude with time constants of less than 2 ms. When the outside-out patches were excised from cells after dopamine incubation, steady-state currents were enhanced and no transient currents were observed. The results may indicate that the dopamine-dependent modulation of glutamate-induced currents, which is presumably mediated by a protein phosphorylation, is due to an alteration of the desensitization of the glutamate receptors. PMID:7520178
Shaping non-diffracting beams with a digital micromirror device

NASA Astrophysics Data System (ADS)

Ren, Yu-Xuan; Fang, Zhao-Xiang; Lu, Rong-De

2016-02-01

The micromechanical digital micromirror device (DMD) performs as a spatial light modulator to shape the light wavefront. Different from the liquid crystal devices, which use the birefringence to modulate the light wave, the DMD regulates the wavefront through an amplitude modulation with the digitally controlled mirrors switched on and off. The advantages of such device are the fast speed, polarization insensitivity, and the broadband modulation ability. The fast switching ability for the DMD not only enables the shaping of static light mode, but also could dynamically compensate for the wavefront distortion due to scattering medium. We have employed such device to create the higher order modes, including the Laguerre-Gaussian, Hermite-Gaussian, as well as Mathieu modes. There exists another kind of beam with shape-preservation against propagation, and self-healing against obstacles. Representative modes are the Bessel modes, Airy modes, and the Pearcey modes. Since the DMD modulates the light intensity, a series of algorithms are developed to calculate proper amplitude hologram for shaping the light. The quasi-continuous gray scale images could imitate the continuous amplitude hologram, while the binary amplitude modulation is another means to create the modulation pattern for a steady light field. We demonstrate the generation of the non-diffracting beams with the binary amplitude modulation via the DMD, and successfully created the non-diffracting Bessel beam, Airy beam, and the Pearcey beam. We have characterized the non-diffracting modes through propagation measurements as well as the self-healing measurements.
Fast terahertz optoelectronic amplitude modulator based on plasmonic metamaterial antenna arrays and graphene

NASA Astrophysics Data System (ADS)

Jessop, David S.; Sol, Christian W. O.; Xiao, Long; Kindness, Stephen J.; Braeuninger-Weimer, Philipp; Lin, Hungyen; Griffiths, Jonathan P.; Ren, Yuan; Kamboj, Varun S.; Hofmann, Stephan; Zeitler, J. Axel; Beere, Harvey E.; Ritchie, David A.; Degl'Innocenti, Riccardo

2016-02-01

The growing interest in terahertz (THz) technologies in recent years has seen a wide range of demonstrated applications, spanning from security screening, non-destructive testing, gas sensing, to biomedical imaging and communication. Communication with THz radiation offers the advantage of much higher bandwidths than currently available, in an unallocated spectrum. For this to be realized, optoelectronic components capable of manipulating THz radiation at high speeds and high signal-to-noise ratios must be developed. In this work we demonstrate a room temperature frequency dependent optoelectronic amplitude modulator working at around 2 THz, which incorporates graphene as the tuning medium. The architecture of the modulator is an array of plasmonic dipole antennas surrounded by graphene. By electrostatically doping the graphene via a back gate electrode, the reflection characteristics of the modulator are modified. The modulator is electrically characterized to determine the graphene conductivity and optically characterization, by THz time-domain spectroscopy and a single-mode 2 THz quantum cascade laser, to determine the optical modulation depth and cut-off frequency. A maximum optical modulation depth of ~ 30% is estimated and is found to be most (least) sensitive when the electrical modulation is centered at the point of maximum (minimum) differential resistivity of the graphene. A 3 dB cut-off frequency > 5 MHz, limited only by the area of graphene on the device, is reported. The results agree well with theoretical calculations and numerical simulations, and demonstrate the first steps towards ultra-fast, graphene based THz optoelectronic devices.
Thermal and optical performance of encapsulation systems for flat-plate photovoltaic modules

NASA Technical Reports Server (NTRS)

Minning, C. P.; Coakley, J. F.; Perrygo, C. M.; Garcia, A., III; Cuddihy, E. F.

1981-01-01

The electrical power output from a photovoltaic module is strongly influenced by the thermal and optical characteristics of the module encapsulation system. Described are the methodology and computer model for performing fast and accurate thermal and optical evaluations of different encapsulation systems. The computer model is used to evaluate cell temperature, solar energy transmittance through the encapsulation system, and electric power output for operation in a terrestrial environment. Extensive results are presented for both superstrate-module and substrate-module design schemes which include different types of silicon cell materials, pottants, and antireflection coatings.
Comparison of results of fluconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global antifungal surveillance program.

PubMed

Pfaller, M A; Hazen, K C; Messer, S A; Boyken, L; Tendolkar, S; Hollis, R J; Diekema, D J

2004-08-01

The accuracy of antifungal susceptibility tests is important for accurate resistance surveillance and for the clinical management of patients with serious infections. Our main objective was to compare the results of fluconazole disk diffusion testing of Candida spp. performed by ARTEMIS participating centers with disk diffusion and MIC results obtained by the central reference laboratory. A total of 2,949 isolates of Candida spp. were tested by NCCLS disk diffusion and reference broth microdilution methods in the central reference laboratory. These results were compared to the results of disk diffusion testing performed in the 54 participating centers. All tests were performed and interpreted following NCCLS recommendations. Overall categorical agreement between participant disk diffusion test results and reference laboratory MIC results was 87.4%, with 0.2% very major errors (VME) and 3.3% major errors (ME). The categorical agreement between the disk diffusion test results obtained in the reference laboratory with the MIC test results was similar: 92.8%. Likewise, good agreement was observed between participant disk diffusion test results and reference laboratory disk diffusion test results: 90.4%, 0.4% VME, and 3.4% ME. The disk diffusion test was especially reliable in detecting those isolates of Candida spp. that were characterized as resistant by reference MIC testing. External quality assurance data obtained by surveillance programs such as the ARTEMIS Global Antifungal Surveillance Program ensure the generation of useful surveillance data and result in the continued improvement of antifungal susceptibility testing practices.
New control system for the 1.5m and 0.9m telescopes at Sierra Nevada Observatory

NASA Astrophysics Data System (ADS)

Costillo, Luis P.; Ramos, J. Luis; Ibáñez, J. Miguel; Aparicio, Beatriz; Herránz, Miguel; García, Antonio J.

2006-06-01

The Sierra Nevada Observatory (Granada, Spain) has a number of telescopes. Our study will focus on two Nasmyth telescopes with apertures of 1.5m and 0.9m and an equatorial mount. The system currently installed to control these telescopes is a 1995 centralized VME module. However, given the problems which have arisen due to the number of wires and other complications, we have decided to change this control module. We will control each telescope with a distributed control philosophy, using a serial linear communication bus between independent nodes, although all system capabilities are accessible from a central unit anywhere and at any time via internet. We have divided the tasks and have one node for alpha control, another for delta control, one for the dome, one for the focus and the central unit to interface with a pc. The nodes for alpha, delta and the dome will be used by means of FPGA's in order to efficiently sample the encoders and the control algorithms, and to generate the output for the motors and the servo. The focus will have a microcontroller, and the system is easy to expand in the event of the inclusion of more nodes. After having studied several fieldbus systems, we have opted for the CAN bus, because of its reliability and broadcasting possibilities. In this way, all the important information will be on the bus, and every node will be able to access the information at any time. This document explains the new design made in the IAA for the new consoles of control whose basic characteristics are, the distributed control, the hardware simplify, the cable remove, the safety and maintenance improve and facilitating the observation improving the interface with the user, and finally to prepare the system for the remote observation.

Green Bank Telescope active surface system

NASA Astrophysics Data System (ADS)

Lacasse, Richard J.

1998-05-01

During the design phase of the Green Bank Telescope (GBT), various means of providing an accurate surface on a large aperture paraboloid, were considered. Automated jacks supporting the primary reflector were selected as the appropriate technology since they promised greater performance and potentially lower costs than a homologous or carbon fiber design, and had certain advantages over an active secondary. The design of the active surface has presented many challenges. Since the actuators are mounted on a tipping structure, it was required that they support a significant side-load. Such devices were not readily available commercially so they had to be developed. Additional actuator requirements include low backlash, repeatable positioning, and an operational life of at least 230 years. Similarly, no control system capable of controlling the 2209 actuators was commercially available. Again a prime requirement was reliability. Maintaining was also a very important consideration. The system architecture is tree-like. An active surface 'master-computer' controls interaction with the telescope control system, and controls ancillary equipment such as power supplies and temperature monitors. Two slave computers interface with the master- computer, and each closes approximately 1100 position loops. For simplicity, the servo is an 'on/off' type, yet achieves a positioning resolution of 25 microns. Each slave computer interfaces with 4 VME I/O cards, which in turn communicate with 140 control modules. The control modules read out the positions of the actuators every 0.1 sec and control the actuators' DC motors. Initial control of the active surface will be based on an elevation dependant structural model. Later, the model will be improved by holographic observations.Surface accuracy will be improved further by using laser ranging system which will actively measure the surface figure. Several tests have been conducted to assure that the system will perform as desired when installed on the telescope. These include actuator life tests, motor life test, position transducer accuracy test, as well as positioning accuracy tests.
Focusing light through dynamical samples using fast continuous wavefront optimization.

PubMed

Blochet, B; Bourdieu, L; Gigan, S

2017-12-01

We describe a fast continuous optimization wavefront shaping system able to focus light through dynamic scattering media. A micro-electro-mechanical system-based spatial light modulator, a fast photodetector, and field programmable gate array electronics are combined to implement a continuous optimization of a wavefront with a single-mode optimization rate of 4.1 kHz. The system performances are demonstrated by focusing light through colloidal solutions of TiO 2 particles in glycerol with tunable temporal stability.
A hybrid silicon membrane spatial light modulator for optical information processing

NASA Technical Reports Server (NTRS)

Pape, D. R.; Hornbeck, L. J.

1984-01-01

A new two dimensional, fast, analog, electrically addressable, silicon based membrane spatial light modulator (SLM) was developed for optical information processing applications. Coherent light reflected from the mirror elements is phase modulated producing an optical Fourier transform of an analog signal input to the device. The DMD architecture and operating parameters related to this application are presented. A model is developed that describes the optical Fourier transform properties of the DMD.
FAST TRACK COMMUNICATION: Stable propagation of a modulated positron beam in a bent crystal channel

NASA Astrophysics Data System (ADS)

Kostyuk, A.; Korol, A. V.; Solov'yov, A. V.; Greiner, W.

2010-08-01

The propagation of a modulated positron beam in a planar crystal channel is investigated. It is demonstrated that the beam preserves its modulation at sufficiently large penetration depths, which opens the prospect of using a crystalline undulator as a coherent source of hard x-rays. This finding is a crucial milestone in developing a new type of laser radiating in the hard x-ray and gamma-ray range.
The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase

PubMed Central

Francis, Kevin; Sapienza, Paul J.; Lee, Andrew L.; Kohen, Amnon

2016-01-01

Dihydrofolate reductase (DHFR) from Escherichia coli has long served as a model enzyme with which to elucidate possible links between protein dynamics and the catalyzed reaction. Such physical properties of its human counterpart have not been rigorously studied so far, but recent computer-based simulations suggest that these two DHFRs differ significantly in how closely coupled the protein dynamics and the catalyzed C-H→C hydride transfer step are. To test this prediction, two contemporary probes for studying the effect of protein dynamics on catalysis were combined here: temperature dependence of intrinsic kinetic isotope effects (KIEs) that are sensitive to the physical nature of the chemical step, and protein mass-modulation that slows down fast dynamics (femto- to picosecond timescale) throughout the protein. The intrinsic H/T KIEs of human DHFR, like those of E. coli DHFR, are shown to be temperature-independent in the range from 5–45 °C, indicating fast sampling of donor and acceptor distances (DADs) at the reaction’s transition state (or tunneling ready state – TRS). Mass modulation of these enzymes through isotopic labeling with 13C, 15N, and 2H at nonexchangeable hydrogens yield an 11% heavier enzyme. The additional mass has no effect on the intrinsic KIEs of the human enzyme. This finding indicates that the mass-modulation of the human DHFR affects neither DAD distribution nor the DAD’s conformational sampling dynamics. Furthermore, reduction in the enzymatic turnover number and the dissociation rate constant for the product indicate that the isotopic substitution affects kinetic steps that are not the catalyzed C-H→C hydride transfer. The findings are discussed in terms of fast dynamics and their role in catalysis, the comparison of calculations and experiments, and the interpretation of isotopically-modulated heavy enzymes in general. PMID:26813442
Memory Consolidation within the Central Amygdala Is Not Necessary for Modulation of Cerebellar Learning

ERIC Educational Resources Information Center

Steinmetz, Adam B.; Ng, Ka H.; Freeman, John H.

2017-01-01

Amygdala lesions impair, but do not prevent, acquisition of cerebellum-dependent eyeblink conditioning suggesting that the amygdala modulates cerebellar learning. Two-factor theories of eyeblink conditioning posit that a fast-developing memory within the amygdala facilitates slower-developing memory within the cerebellum. The current study tested…
Feature-fused SSD: fast detection for small objects

NASA Astrophysics Data System (ADS)

Cao, Guimei; Xie, Xuemei; Yang, Wenzhe; Liao, Quan; Shi, Guangming; Wu, Jinjian

2018-04-01

Small objects detection is a challenging task in computer vision due to its limited resolution and information. In order to solve this problem, the majority of existing methods sacrifice speed for improvement in accuracy. In this paper, we aim to detect small objects at a fast speed, using the best object detector Single Shot Multibox Detector (SSD) with respect to accuracy-vs-speed trade-off as base architecture. We propose a multi-level feature fusion method for introducing contextual information in SSD, in order to improve the accuracy for small objects. In detailed fusion operation, we design two feature fusion modules, concatenation module and element-sum module, different in the way of adding contextual information. Experimental results show that these two fusion modules obtain higher mAP on PASCAL VOC2007 than baseline SSD by 1.6 and 1.7 points respectively, especially with 2-3 points improvement on some small objects categories. The testing speed of them is 43 and 40 FPS respectively, superior to the state of the art Deconvolutional single shot detector (DSSD) by 29.4 and 26.4 FPS.
Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains.

PubMed

Conti Nibali, Valeria; Morra, Giulia; Havenith, Martina; Colombo, Giorgio

2017-11-09

With the aim of investigating the relationship between the fast fluctuations of proteins and their allosteric behavior, we perform molecular dynamics simulations of two model PDZ domains with differential allosteric responses. We focus on protein dynamics in the THz regime (0.1-3 THz) as opposed to lower frequencies. By characterizing the dynamic modulation of the protein backbone induced by ligand binding in terms of single residue and pairwise distance fluctuations, we identify a response nucleus modulated by the ligand that is visible only at THz frequencies. The residues of this nucleus undergo a significant stiffening and an increase in mutual coordination upon binding. Additionally, we find that the dynamic modulation is significantly more intense for the side chains, where it is also redistributed to distal regions not immediately in contact with the ligand allowing us to better define the response nucleus at THz frequencies. The overlap between the known allosterically responding residues of the investigated PDZ domains and the modulated region highlighted here suggests that fast THz dynamics could play a role in allosteric mechanisms.
Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice.

PubMed

Pedroso, João A B; Silveira, Marina A; Lima, Leandro B; Furigo, Isadora C; Zampieri, Thais T; Ramos-Lobo, Angela M; Buonfiglio, Daniella C; Teixeira, Pryscila D S; Frazão, Renata; Donato, Jose

2016-10-01

Weight regain frequently follows interventions that reduce body weight, leading to a failure in long-term obesity treatment. Inhibitory proteins of the leptin signaling pathway, such as the suppressor of cytokine signaling 3 (SOCS3), have been studied in conditions that predispose animals to obesity. However, whether SOCS3 modulates postrestriction hyperphagia and weight regain remains unknown. Mice lacking SOCS3 protein specifically in leptin receptor (LepR)-expressing cells (LepR SOCS3 knockout [KO]) were generated and studied in fasting and refeeding conditions. LepR SOCS3 KO mice exhibited increased leptin sensitivity in the hypothalamus. Notably, LepR SOCS3 KO males and females showed attenuated food intake and weight regain after 48 hours of fasting. Postrestriction hyperleptinemia was also prevented in LepR SOCS3 KO mice. Next, we studied possible mechanisms and neural circuits involved in the SOCS3 effects. SOCS3 deletion did not prevent fasting- or refeeding-induced c-Fos expression in the arcuate nucleus of the hypothalamus (ARH) nor fasting-induced increased excitability of ARH LepR-expressing cells. On the other hand, SOCS3 ablation reduced the mRNA levels of hypothalamic orexigenic neuropeptides during fasting (neuropeptide Y, agouti-related protein, orexin, and melanin-concentrating hormone). In summary, our findings suggest that increased leptin sensitivity contributes to the maintenance of a reduced body weight after food deprivation. In addition, the attenuated postrestriction food intake observed in mutant mice was not explained by fasting-induced changes in the activity of ARH neurons but exclusively by a lower transcription of orexigenic neuropeptides during fasting. These results indicate a partial dissociation between the regulation of neuronal activity and gene expression in ARH LepR-expressing cells.
Intrinsic neuromodulation in the Tritonia swim CPG: serotonin mediates both neuromodulation and neurotransmission by the dorsal swim interneurons.

PubMed

Katz, P S; Frost, W N

1995-12-01

1. Neuromodulation has previously been shown to be intrinsic to the central pattern generator (CPG) circuit that generates the escape swim of the nudibranch mollusk Tritonia diomedea; the dorsal swim interneurons (DSIs) make conventional monosynaptic connections and evoke neuromodulatory effects within the swim motor circuit. The conventional synaptic potentials evoked by a DSI onto cerebral neuron 2 (C2) and onto the dorsal flexion neurons (DFNs) consist of a fast excitatory postsynaptic potential (EPSP) followed by a prolonged slow EPSP. In their neuromodulatory role, the DSIs produce an enhancement of the monosynaptic connections made by C2 onto other CPG circuit interneurons and onto efferent flexion neurons. Previous work showed that the DSIs are immunoreactive for serotonin. Here we provide evidence that both the neurotransmission and the neuromodulation evoked by the DSIs are produced by serotonin, and that these effects may be pharmacologically separable. 2. Previously it was shown that bath-applied serotonin both mimics and occludes the modulation of the C2 synapses by the DSIs. Here we find that pressure-applied puffs of serotonin mimic both the fast and slow EPSPs evoked by a DSI onto a DFN, whereas high concentrations of bath-applied serotonin occlude both of these synaptic components. 3. Consistent with the hypothesis that serotonin mediates the actions of the DSIs, the serotonin reuptake inhibitor imipramine prolongs the duration of the fast DSI-DFN EPSP, increases the amplitude of the slow DSI-DFN EPSP, and increases both the amplitude and duration of the modulation of the C2-DFN synapse by the DSIs. 4. Two serotonergic antagonists were found that block the actions of the DSIs. Gramine blocks the fast DSI-DFN EPSP, and has far less of an effect on the slow EPSP and the modulation. Gramine also diminishes the depolarization evoked by pressure-applied serotonin, showing that it is a serotonin antagonist in this system. In contrast, methysergide greatly reduces both the slow EPSP and the modulation evoked by the DSIs, but has mixed effects on the fast EPSP. Methysergide also blocks the ability of exogenous serotonin to enhance the C2-DFN EPSP, demonstrating that it antagonizes the serotonin receptors responsible for this modulation. 5. Taken together with previous work, these results indicate that serotonin is likely to be responsible for all three actions of the DSIs that were examined: the fast and slow DSI-DFN EPSPs and the neuromodulation of the C2-DFN synapse. These results also indicate that the conventional and neuromodulatory effects of the DSIs may be pharmacologically separable. In future work it may be possible to determine the functional role of each in the swim circuit.
FAST MAGNETOACOUSTIC WAVE TRAINS OF SAUSAGE SYMMETRY IN CYLINDRICAL WAVEGUIDES OF THE SOLAR CORONA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shestov, S.; Kuzin, S.; Nakariakov, V. M., E-mail: sshestov@gmail.com

2015-12-01

Fast magnetoacoustic waves guided along the magnetic field by plasma non-uniformities, in particular coronal loops, fibrils, and plumes, are known to be highly dispersive, which lead to the formation of quasi-periodic wave trains excited by a broadband impulsive driver, e.g., a solar flare. We investigated the effects of cylindrical geometry on the fast sausage wave train formation. We performed magnetohydrodynamic numerical simulations of fast magnetoacoustic perturbations of a sausage symmetry, propagating from a localized impulsive source along a field-aligned plasma cylinder with a smooth radial profile of the fast speed. The wave trains are found to have pronounced period modulation,more » with the longer instant period seen in the beginning of the wave train. The wave trains also have a pronounced amplitude modulation. Wavelet spectra of the wave trains have characteristic tadpole features, with the broadband large-amplitude heads preceding low-amplitude quasi-monochromatic tails. The mean period of the wave train is about the transverse fast magnetoacoustic transit time across the cylinder. The mean parallel wavelength is about the diameter of the wave-guiding plasma cylinder. Instant periods are longer than the sausage wave cutoff period. The wave train characteristics depend on the fast magnetoacoustic speed in both the internal and external media, the smoothness of the transverse profile of the equilibrium quantities, and also the spatial size of the initial perturbation. If the initial perturbation is localized at the axis of the cylinder, the wave trains contain higher radial harmonics that have shorter periods.« less
Dispersion induced power fading for radio frequency signals and its application for fast online PMD and CD monitoring

NASA Astrophysics Data System (ADS)

Ning, G.; Shum, P.

2007-06-01

We derive the expressions for the power fading including first-order polarization mode dispersion (PMD), chromatic dispersion, chirp parameter as well as polarization-dependent chromatic dispersion (PCD), which is dependent on the angle of precession of output state of polarization around the PMD vector. From the expression for radio frequency (RF) signals power fading, we get the average power fading for chromatic dispersion, chirp parameter, first-order PMD and PCD for both double sideband (DSB) modulation and single sideband (SSB) modulation. We also demonstrate a fast PMD and chromatic dispersion monitoring technology with reduced polarization-dependent gain. The measured results agree well with theoretical analysis.
Plasmonic phased array feeder enabling ultra-fast beam steering at millimeter waves.

PubMed

Bonjour, R; Burla, M; Abrecht, F C; Welschen, S; Hoessbacher, C; Heni, W; Gebrewold, S A; Baeuerle, B; Josten, A; Salamin, Y; Haffner, C; Johnston, P V; Elder, D L; Leuchtmann, P; Hillerkuss, D; Fedoryshyn, Y; Dalton, L R; Hafner, C; Leuthold, J

2016-10-31

In this paper, we demonstrate an integrated microwave phoneeded for beamtonics phased array antenna feeder at 60 GHz with a record-low footprint. Our design is based on ultra-compact plasmonic phase modulators (active area <2.5µm²) that not only provide small size but also ultra-fast tuning speed. In our design, the integrated circuit footprint is in fact only limited by the contact pads of the electrodes and by the optical feeding waveguides. Using the high speed of the plasmonic modulators, we demonstrate beam steering with less than 1 ns reconfiguration time, i.e. the beam direction is reconfigured in-between 1 GBd transmitted symbols.
The muon pretrigger system of the HERA-B experiment

NASA Astrophysics Data System (ADS)

Bocker, M.; Adams, M.; Bechtle, P.; Buchholz, P.; Cruse, C.; Husemann, U.; Klaus, E.; Koch, N.; Kolander, M.; Kolotaev, I.; Riege, H.; Schutt, J.; Schwenninger, B.; van Staa, R.; Wegener, D.

2001-08-01

One of the main goals of the HERA-B experiment at DESY in Hamburg, Germany, is to study the properties of B-mesons with the emphasis on CP violation. B-mesons are produced in hadronic interactions of a 920-GeV proton beam with an internal wire target. An effective bunch crossing rate of about 8.5 MHz leads to about 200 charged tracks per event. Therefore, a highly selective and efficient trigger system providing high suppression of background events is required. The HERA-B trigger system consists of four levels. A rate reduction factor of 200 is aimed at by the first-level trigger (FLT). The muon pretrigger system, as a part of the FLT, is a modular system consisting of about 100 large-size VME modules of three different types: the pretrigger link board (PLB), the pretrigger coincidence unit (PCU), and the pretrigger message generator (PMG). The data rate processed by the pretrigger system is about 19.5 GByte/s. The PLBs process digitized hit information in eight independent electronic channels in parallel. Every electronic channel handles 32 bits of hit information received from the front-end driver buffer system. Optical links operating at 800 Mb/s transmit the data after serialization to PCUs, which calculate coincidences using complex programmable logic devices. The PMGs transform this coincidence information into messages for the FLT processors. The concept and design as well as results of the muon pretrigger running at HERA-B are presented.
Laser frequency-offset locking based on the frequency modulation spectroscopy with higher harmonic detection

NASA Astrophysics Data System (ADS)

Wang, Anqi; Meng, Zhixin; Feng, Yanying

2017-10-01

We design a fiber electro-optic modulator (FEOM)-based laser frequency-offset locking system using frequency modulation spectroscopy (FMS) with the 3F modulation. The modulation signal and the frequency-offset control signal are simultaneously loaded on the FEOM by a mixer in order to suppress the frequency and power jitter caused by internal modulation on the current or piezoelectric ceramic transducer (PZT). It is expected to accomplish a fast locking, a widely tunable frequency-offset, a sensitive and rapid detection of narrow spectral features with the 3F modulation. The laser frequency fluctuation is limited to +/-1MHz and its overlapping Allan deviation is around 10-12 in twenty minutes, which successfully meets the requirements of the cold atom interferometer.
Method and Apparatus for Improved Spatial Light Modulation

NASA Technical Reports Server (NTRS)

Soutar, Colin (Inventor); Juday, Richard D. (Inventor)

2000-01-01

A method and apparatus for modulating a light beam in an optical processing system is described. Preferably, an electrically-controlled polarizer unit and/or an analyzer unit are utilized in combination with a spatial light modulator and a controller. Preferably, the spatial light modulator comprises a pixelated birefringent medium such as a liquid crystal video display. The combination of the electrically controlled polarizer unit and analyzer unit make it simple and fast to reconfigure the modulation described by the Jones matrix of the spatial light modulator. A particular optical processing objective is provided to the controller. The controller performs calculations and supplies control signals to the polarizer unit, the analyzer unit, and the spatial light modulator in order to obtain the optical processing objective.
Method and Apparatus for Improved Spatial Light Modulation

NASA Technical Reports Server (NTRS)

Colin, Soutar (Inventor); Juday, Richard D. (Inventor)

1999-01-01

A method and apparatus for modulating a light beam in an optical processing system is described. Preferably, an electrically-controlled polarizer unit and/or an analyzer unit are utilized in combination with a spatial light modulator and a controller. Preferably, the spatial light modulator comprises a pixelated birefringent medium such as a liquid crystal video display. The combination of the electrically controlled polarizer unit and analyzer unit make it simple and fast to reconfigure the modulation described by the Jones matrix of the spatial light modulator. A particular optical processing objective is provided to the controller. The controller performs calculations and supplies control signals to the polarizer unit, the analyzer unit, and the spatial light modulator in order to obtain die optical processing objective.
Proceedings of the Ship Control Systems Symposium (9th) Held in Bethesda, Maryland on 10-14 September 1990. Theme: Automation in Surface Ship Control Systems, Today’s Applications and Future Trends. Volume 1

DTIC Science & Technology

1990-09-14

transmission of detected variations through sound lines of communication to centrally located standard Navy computers . These computers would be programmed to...have been programmed in C language. The program runs under the operating system ,OS9 on a VME-bus computer with a 68000 microprocessor. A number of full...present practice of"add-on" supervisory controls during ship design and construction,and "fix-it" R&D programs implemented after the ship isoperational
Real-Time Symbol Extraction From Grey-Level Images

NASA Astrophysics Data System (ADS)

Massen, R.; Simnacher, M.; Rosch, J.; Herre, E.; Wuhrer, H. W.

1988-04-01

A VME-bus image pipeline processor for extracting vectorized contours from grey-level images in real-time is presented. This 3 Giga operation per second processor uses large kernel convolvers and new non-linear neighbourhood processing algorithms to compute true 1-pixel wide and noise-free contours without thresholding even from grey-level images with quite varying edge sharpness. The local edge orientation is used as an additional cue to compute a list of vectors describing the closed and open contours in real-time and to dump a CAD-like symbolic image description into a symbol memory at pixel clock rate.
Implementation and validation of an economic module in the Be-FAST model to predict costs generated by livestock disease epidemics: Application to classical swine fever epidemics in Spain.

PubMed

Fernández-Carrión, E; Ivorra, B; Martínez-López, B; Ramos, A M; Sánchez-Vizcaíno, J M

2016-04-01

Be-FAST is a computer program based on a time-spatial stochastic spread mathematical model for studying the transmission of infectious livestock diseases within and between farms. The present work describes a new module integrated into Be-FAST to model the economic consequences of the spreading of classical swine fever (CSF) and other infectious livestock diseases within and between farms. CSF is financially one of the most damaging diseases in the swine industry worldwide. Specifically in Spain, the economic costs in the two last CSF epidemics (1997 and 2001) reached jointly more than 108 million euros. The present analysis suggests that severe CSF epidemics are associated with significant economic costs, approximately 80% of which are related to animal culling. Direct costs associated with control measures are strongly associated with the number of infected farms, while indirect costs are more strongly associated with epidemic duration. The economic model has been validated with economic information around the last outbreaks in Spain. These results suggest that our economic module may be useful for analysing and predicting economic consequences of livestock disease epidemics. Copyright © 2016 Elsevier B.V. All rights reserved.

A non-linear 4-wave resonant model for non-perturbative fast ion interactions with Alfv'enic modes in burning plasmas

NASA Astrophysics Data System (ADS)

Zonca, Fulvio; Chen, Liu

2007-11-01

We adopt the 4-wave modulation interaction model, introduced by Chen et al [1] for analyzing modulational instabilities of the radial envelope of Ion Temperature Gradient driven modes in toroidal geometry, extending it to the modulations on the fast particle distribution function due to nonlinear Alfv'enic mode dynamics, as proposed in Ref. [2]. In the case where the wave-particle interactions are non-perturbative and strongly influence the mode evolution, as in the case of Energetic Particle Modes (EPM) [3], radial distortions (redistributions) of the fast ion source dominate the mode nonlinear dynamics. In this work, we show that the resonant particle motion is secular with a time-scale inversely proportional to the mode amplitude [4] and that the time evolution of the EPM radial envelope can be cast into the form of a nonlinear Schr"odinger equation a la Ginzburg-Landau [5]. [1] L. Chen et al, Phys. Plasmas 7 3129 (2000) [2] F. Zonca et al, Theory of Fusion Plasmas (Bologna: SIF) 17 (2000) [3] L. Chen, Phys. Plasmas 1, 1519 (1994).[4] F. Zonca et al, Nucl. Fusion 45 477 (2005) [5] F. Zonca et al, Plasma Phys. Contr. Fusion 48 B15 (2006)
Design of a fast crew transfer vehicle to Mars

NASA Technical Reports Server (NTRS)

1988-01-01

A final report is made on the trajectory and vehicle requirements for a fast crew transfer vehicle to Mars which will complete an Earth to Mars (and Mars to Earth) transfer in 150 days and will have a stay time at Mars of 40 days. This vehicle will maximize the crew's effectiveness on Mars by minimizing detrimental physiological effects such as bone demineralization and loss of muscle tone caused by long period exposure to zero gravity and radiation from cosmic rays and solar flares. The crew transfer vehicle discussed will complete the second half of a Split Mission to Mars. In the Split Mission, a slow, unmanned cargo vehicle, nicknamed the Barge, is sent to Mars ahead of the crew vehicle. Once the Barge is in orbit around Mars, the fast crew vehicle will be launched to rendezvous with the Barge in Mars orbit. The vehicle presented is designed to carry six astronauts for a mission duration of one year. The vehicle uses a chemical propulsion system and a nuclear power system. Four crew modules, similar to the proposed Space Station Common Modules, are used to house the crew and support equipment during the mission. The final design also includes a command module that is shielded to protect the crew during radiation events.
Functional near-infrared spectroscopy at small source-detector distance by means of high dynamic-range fast-gated SPAD acquisitions: first in-vivo measurements

NASA Astrophysics Data System (ADS)

Di Sieno, L.; Contini, D.; Dalla Mora, A.; Torricelli, A.; Spinelli, L.; Cubeddu, R.; Tosi, A.; Boso, G.; Pifferi, A.

2013-06-01

In this article, we show experimental results of time-resolved optical spectroscopy performed with small distance between launching and detecting fibers. It was already demonstrated that depth discrimination is independent of source-detector separation and that measurements at small source detector distance provide better contrast and spatial resolution. The main disadvantage is represent by the huge increase in early photons (scarcely diffused by tissue) peak that can saturate the dynamic range of most detectors, hiding information carried by late photons. Thanks to a fast-gated Single- Photon Avalanche Diode (SPAD) module, we are able to reject the peak of early photons and to obtain high-dynamic range acquisitions. We exploit fast-gated SPAD module to perform for the first time functional near-infrared spectroscopy (fNIRS) at small source-detector distance for in vivo measurements and we demonstrate the possibility to detect non-invasively the dynamics of oxygenated and deoxygenated haemoglobin occurring in the motor cortex during a motor task. We also show the improvement in terms of signal amplitude and Signal-to-Noise Ratio (SNR) obtained exploiting fast-gated SPAD performances with respect to "non-gated" measurements.
Does Language Proficiency Modulate Oculomotor Control? Evidence from Hindi-English Bilinguals

ERIC Educational Resources Information Center

Singh, Niharika; Mishra, Ramesh Kumar

2012-01-01

Though many previous studies have reported enhanced cognitive control in bilinguals, few have investigated if such control is modulated by language proficiency. Here, we examined the inhibitory control of high and low proficient Hindi-English bilinguals on an oculomotor Stroop task. Subjects were asked to make a saccade as fast as possible towards…
A fast and robust TOUGH2 module to simulate geological CO2 storage in saline aquifers

NASA Astrophysics Data System (ADS)

Shabani, Babak; Vilcáez, Javier

2018-02-01

A new TOUGH2 module to simulate geological CO2 storage (GCS) in saline aquifers is developed based on the widely employed ECO2N module of TOUGH2. The newly developed TOUGH2 module uses a new non-iterative fugacity-activity thermodynamic model to obtain the partitioning of CO2 and H2O between the aqueous and gas phases. Simple but robust thermophysical correlations are used to obtain density, viscosity, and enthalpy of the gas phase. The implementation and accuracy of the employed thermophysical correlations are verified by comparisons against the national institute of standards and technology (NIST) online thermophysical database. To assess the computation accuracy and efficiency, simulation results obtained with the new TOUGH2 module for a one-dimensional non-isothermal radial and a three-dimensional isothermal system are compared against the simulation results obtained with the ECO2N module. Treating salt mass fraction in the aqueous phase as a constant, along with the inclusion of a non-iterative fugacity-activity thermodynamic model, and simple thermophysical correlations, resulted in simulations much faster than simulations with ECO2N module, without losing numerical accuracy. Both modules yield virtually identical results. Additional field-scale simulations of CO2 injection into an actual non-isothermal and heterogeneous geological formation confirmed that the new module is much faster than the ECO2N module in simulating complex field-scale conditions. Owing to its capability to handle CO2-CH4-H2S-N2 gas mixtures and its compatibility with TOUGHREACT, this new TOUGH2 module offers the possibility of developing a fast and robust TOUGHREACT module to predict the fate of CO2 in GCS sites under biotic conditions where CO2, CH4, H2S, and N2 gases can be formed.
Gist: A scientific graphics package for Python

DOE Office of Scientific and Technical Information (OSTI.GOV)

Busby, L.E.

1996-05-08

{open_quotes}Gist{close_quotes} is a scientific graphics library written by David H. Munro of Lawrence Livermore National Laboratory (LLNL). It features support for three common graphics output devices: X Windows, (Color) PostScript, and ANSI/ISO Standard Computer Graphics Metafiles (CGM). The library is small (written directly to Xlib), portable, efficient, and full-featured. It produces X versus Y plots with {open_quotes}good{close_quotes} tick marks and tick labels, 2-dimensional quadrilateral mesh plots with contours, vector fields, or pseudo color maps on such meshes, with 3-dimensional plots on the way. The Python Gist module utilizes the new {open_quotes}Numeric{close_quotes} module due to J. Hugunin and others. It ismore » therefore fast and able to handle large datasets. The Gist module includes an X Windows event dispatcher which can be dynamically added (e.g., via importing a dynamically loaded module) to the Python interpreter after a simple two-line modification to the Python core. This makes fast mouse-controlled zoom, pan, and other graphic operations available to the researcher while maintaining the usual Python command-line interface. Munro`s Gist library is already freely available. The Python Gist module is currently under review and is also expected to qualify for unlimited release.« less
A practical implementation of multi-frequency widefield frequency-domain FLIM

PubMed Central

Chen, Hongtao

2013-01-01

Widefield frequency-domain fluorescence lifetime imaging microscopy (FD-FLIM) is a fast and accurate method to measure the fluorescence lifetime, especially in kinetic studies in biomedical researches. However, the small range of modulation frequencies available in commercial instruments makes this technique limited in its applications. Here we describe a practical implementation of multi-frequency widefield FD-FLIM using a pulsed supercontinuum laser and a direct digital synthesizer. In this instrument we use a pulse to modulate the image intensifier rather than the more conventional sine wave modulation. This allows parallel multi-frequency FLIM measurement using the Fast Fourier Transform and the cross-correlation technique, which permits precise and simultaneous isolation of individual frequencies. In addition, the pulse modulation at the cathode of image intensifier restored the loss of optical resolution caused by the defocusing effect when the voltage at the cathode is sinusoidally modulated. Furthermore, in our implementation of this technique, data can be graphically analyzed by the phasor method while data are acquired, which allows easy fit-free lifetime analysis of FLIM images. Here our measurements of standard fluorescent samples and a Föster resonance energy transfer pair demonstrate that the widefield multi-frequency FLIM system is a valuable and simple tool in fluorescence imaging studies. PMID:23296945
Kinematic principles of primate rotational vestibulo-ocular reflex. II. Gravity-dependent modulation of primary eye position

NASA Technical Reports Server (NTRS)

Hess, B. J.; Angelaki, D. E.

1997-01-01

The kinematic constraints of three-dimensional eye positions were investigated in rhesus monkeys during passive head and body rotations relative to gravity. We studied fast and slow phase components of the vestibulo-ocular reflex (VOR) elicited by constant-velocity yaw rotations and sinusoidal oscillations about an earth-horizontal axis. We found that the spatial orientation of both fast and slow phase eye positions could be described locally by a planar surface with torsional variation of <2.0 +/- 0.4 degrees (displacement planes) that systematically rotated and/or shifted relative to Listing's plane. In supine/prone positions, displacement planes pitched forward/backward; in left/right ear-down positions, displacement planes were parallel shifted along the positive/negative torsional axis. Dynamically changing primary eye positions were computed from displacement planes. Torsional and vertical components of primary eye position modulated as a sinusoidal function of head orientation in space. The torsional component was maximal in ear-down positions and approximately zero in supine/prone orientations. The opposite was observed for the vertical component. Modulation of the horizontal component of primary eye position exhibited a more complex dependence. In contrast to the torsional component, which was relatively independent of rotational speed, modulation of the vertical and horizontal components of primary position depended strongly on the speed of head rotation (i.e., on the frequency of oscillation of the gravity vector component): the faster the head rotated relative to gravity, the larger was the modulation. Corresponding results were obtained when a model based on a sinusoidal dependence of instantaneous displacement planes (and primary eye position) on head orientation relative to gravity was fitted to VOR fast phase positions. When VOR fast phase positions were expressed relative to primary eye position estimated from the model fits, they were confined approximately to a single plane with a small torsional standard deviation ( approximately 1.4-2.6 degrees). This reduced torsional variation was in contrast to the large torsional spread (well >10-15 degrees ) of fast phase positions when expressed relative to Listing's plane. We conclude that primary eye position depends dynamically on head orientation relative to space rather than being fixed to the head. It defines a gravity-dependent coordinate system relative to which the torsional variability of eye positions is minimized even when the head is moved passively and vestibulo-ocular reflexes are evoked. In this general sense, Listing's law is preserved with respect to an otolith-controlled reference system that is defined dynamically by gravity.
The Monitoring Case of Ground-Based Synthetic Aperture Radar with Frequency Modulated Continuous Wave System

NASA Astrophysics Data System (ADS)

Zhang, H. Y.; Zhai, Q. P.; Chen, L.; Liu, Y. J.; Zhou, K. Q.; Wang, Y. S.; Dou, Y. D.

2017-09-01

The features of the landslide geological disaster are wide distribution, variety, high frequency, high intensity, destructive and so on. It has become a natural disaster with harmful and wide range of influence. The technology of ground-based synthetic aperture radar is a novel deformation monitoring technology developed in recent years. The features of the technology are large monitoring area, high accuracy, long distance without contact and so on. In this paper, fast ground-based synthetic aperture radar (Fast-GBSAR) based on frequency modulated continuous wave (FMCW) system is used to collect the data of Ma Liuzui landslide in Chongqing. The device can reduce the atmospheric errors caused by rapidly changing environment. The landslide deformation can be monitored in severe weather conditions (for example, fog) by Fast-GBSAR with acquisition speed up to 5 seconds per time. The data of Ma Liuzui landslide in Chongqing are analyzed in this paper. The result verifies that the device can monitor landslide deformation under severe weather conditions.
The Rapid Distortion of Two-Way Coupled Particle-Laden Turbulence

NASA Astrophysics Data System (ADS)

Kasbaoui, Mohamed; Koch, Donald; Desjardins, Olivier

2017-11-01

The modulation of sheared turbulence by dispersed particles is addressed in the two-way coupling regime. The preferential sampling of the straining regions of the flow by inertial particles in turbulence leads to the formation of clusters. These fast sedimenting particle structures cause the anisotropic alteration of turbulence at small scales in the direction of gravity. These effects are investigated in a revisited Rapid Distortion Theory (RDT), extended for two-way coupled particle-laden flows. To make the analysis tractable, we assume that particles have small but non-zero inertia. In the classical results for single-phase flows, the RDT assumption of fast shearing compared to the turbulence time scales leads to the distortion of ``frozen'' turbulence. In particle-laden turbulence, the coupling between the two phases remains strong even under fast shearing and leads to a dynamic modulation of the turbulence spectrum. Turbulence statistics obtained from RDT are compared with Euler-Lagrange simulations of homogeneously sheared particle-laden turbulence.
Modified slanted-edge method for camera modulation transfer function measurement using nonuniform fast Fourier transform technique

NASA Astrophysics Data System (ADS)

Duan, Yaxuan; Xu, Songbo; Yuan, Suochao; Chen, Yongquan; Li, Hongguang; Da, Zhengshang; Gao, Limin

2018-01-01

ISO 12233 slanted-edge method experiences errors using fast Fourier transform (FFT) in the camera modulation transfer function (MTF) measurement due to tilt angle errors in the knife-edge resulting in nonuniform sampling of the edge spread function (ESF). In order to resolve this problem, a modified slanted-edge method using nonuniform fast Fourier transform (NUFFT) for camera MTF measurement is proposed. Theoretical simulations for images with noise at a different nonuniform sampling rate of ESF are performed using the proposed modified slanted-edge method. It is shown that the proposed method successfully eliminates the error due to the nonuniform sampling of the ESF. An experimental setup for camera MTF measurement is established to verify the accuracy of the proposed method. The experiment results show that under different nonuniform sampling rates of ESF, the proposed modified slanted-edge method has improved accuracy for the camera MTF measurement compared to the ISO 12233 slanted-edge method.
A proposed computer diagnostic system for malignant melanoma (CDSMM).

PubMed

Shao, S; Grams, R R

1994-04-01

This paper describes a computer diagnostic system for malignant melanoma. The diagnostic system is a rule base system based on image analyses and works under the PC windows environment. It consists of seven modules: I/O module, Patient/Clinic database, image processing module, classification module, rule base module and system control module. In the system, the image analyses are automatically carried out, and database management is efficient and fast. Both final clinic results and immediate results from various modules such as measured features, feature pictures and history records of the disease lesion can be presented on screen or printed out from each corresponding module or from the I/O module. The system can also work as a doctor's office-based tool to aid dermatologists with details not perceivable by the human eye. Since the system operates on a general purpose PC, it can be made portable if the I/O module is disconnected.
Semitransparent organic photovoltaic modules with Ag nanowire top electrodes

NASA Astrophysics Data System (ADS)

Guo, Fei; Kubis, Peter; Przybilla, Thomas; Spiecker, Erdmann; Forberich, Karen; Brabec, Christoph J.

2014-10-01

Semitransparent organic photovoltaic (OPV) cells are promising for applications in transparent architectures where their opaque counterparts are not suitable. Manufacturing of large-area modules without performance losses compared to their lab-scale devices is a key step towards practical applications of this PV technology. In this paper, we report the use of solution-processed silver nanowires as top electrodes and fabricate semitransparent OPV modules based on ultra-fast laser scribing. Through a rational choice of device architecture in combination with high-precision laser patterning, we demonstrate efficient semitransparent modules with comparable performance as compared to the reference devices.
Reservoir computing with a slowly modulated mask signal for preprocessing using a mutually coupled optoelectronic system

NASA Astrophysics Data System (ADS)

Tezuka, Miwa; Kanno, Kazutaka; Bunsen, Masatoshi

2016-08-01

Reservoir computing is a machine-learning paradigm based on information processing in the human brain. We numerically demonstrate reservoir computing with a slowly modulated mask signal for preprocessing by using a mutually coupled optoelectronic system. The performance of our system is quantitatively evaluated by a chaotic time series prediction task. Our system can produce comparable performance with reservoir computing with a single feedback system and a fast modulated mask signal. We showed that it is possible to slow down the modulation speed of the mask signal by using the mutually coupled system in reservoir computing.
A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein

NASA Technical Reports Server (NTRS)

Ratner, N.; Bloom, G. S.; Brady, S. T.

1998-01-01

Proteins that interact with both cytoskeletal and membrane components are candidates to modulate membrane trafficking. The tumor suppressor proteins neurofibromin (NF1) and adenomatous polyposis coli (APC) both bind to microtubules and interact with membrane-associated proteins. The effects of recombinant NF1 and APC fragments on vesicle motility were evaluated by measuring fast axonal transport along microtubules in axoplasm from squid giant axons. APC4 (amino acids 1034-2844) reduced only anterograde movements, whereas APC2 (aa 1034-2130) or APC3 (aa 2130-2844) reduced both anterograde and retrograde transport. NF1 had no effect on organelle movement in either direction. Because APC contains multiple cyclin-dependent kinase (CDK) consensus phosphorylation motifs, the kinase inhibitor olomoucine was examined. At concentrations in which olomoucine is specific for cyclin-dependent kinases (5 microM), it reduced only anterograde transport, whereas anterograde and retrograde movement were both affected at concentrations at which other kinases are inhibited as well (50 microM). Both anterograde and retrograde transport also were inhibited by histone H1 and KSPXK peptides, substrates for proline-directed kinases, including CDKs. Our data suggest that CDK-like axonal kinases modulate fast anterograde transport and that other axonal kinases may be involved in modulating retrograde transport. The specific effect of APC4 on anterograde transport suggests a model in which the binding of APC to microtubules may limit the activity of axonal CDK kinase or kinases in restricted domains, thereby affecting organelle transport.
Lossless crossing of a resonance stopband during tune modulation by synchrotron oscillations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, G. M.; Shaftan, T.; Smaluk, V.

Modern high performance circular accelerators require sophisticated corrections of nonlinear lattices. The beam betatron tune footprint may cross many resonances, reducing dynamic aperture and causing particle loss. But, if particles cross a resonance reasonably fast, the beam deterioration may be minimized. This paper describes the experiments with the beam passing through a half-integer resonance stopband via tune modulation by exciting synchrotron oscillations. This is the first time that beam dynamics have been kept under precise control while the beam crosses a half-integer resonance. These results convincingly demonstrate that particles can cross the half-integer resonance without being lost if the passagemore » is reasonably fast and the resonance stopband is sufficiently narrow.« less
Lossless crossing of a resonance stopband during tune modulation by synchrotron oscillations

DOE PAGES

Wang, G. M.; Shaftan, T.; Smaluk, V.; ...

2017-09-14

Modern high performance circular accelerators require sophisticated corrections of nonlinear lattices. The beam betatron tune footprint may cross many resonances, reducing dynamic aperture and causing particle loss. But, if particles cross a resonance reasonably fast, the beam deterioration may be minimized. This paper describes the experiments with the beam passing through a half-integer resonance stopband via tune modulation by exciting synchrotron oscillations. This is the first time that beam dynamics have been kept under precise control while the beam crosses a half-integer resonance. These results convincingly demonstrate that particles can cross the half-integer resonance without being lost if the passagemore » is reasonably fast and the resonance stopband is sufficiently narrow.« less
Magnitude and Temporal Variability of Inter-stimulus EEG Modulate the Linear Relationship Between Laser-Evoked Potentials and Fast-Pain Perception

PubMed Central

Li, Linling; Huang, Gan; Lin, Qianqian; Liu, Jia; Zhang, Shengli; Zhang, Zhiguo

2018-01-01

The level of pain perception is correlated with the magnitude of pain-evoked brain responses, such as laser-evoked potentials (LEP), across trials. The positive LEP-pain relationship lays the foundation for pain prediction based on single-trial LEP, but cross-individual pain prediction does not have a good performance because the LEP-pain relationship exhibits substantial cross-individual difference. In this study, we aim to explain the cross-individual difference in the LEP-pain relationship using inter-stimulus EEG (isEEG) features. The isEEG features (root mean square as magnitude and mean square successive difference as temporal variability) were estimated from isEEG data (at full band and five frequency bands) recorded between painful stimuli. A linear model was fitted to investigate the relationship between pain ratings and LEP response for fast-pain trials on a trial-by-trial basis. Then the correlation between isEEG features and the parameters of LEP-pain model (slope and intercept) was evaluated. We found that the magnitude and temporal variability of isEEG could modulate the parameters of an individual's linear LEP-pain model for fast-pain trials. Based on this, we further developed a new individualized fast-pain prediction scheme, which only used training individuals with similar isEEG features as the test individual to train the fast-pain prediction model, and obtained improved accuracy in cross-individual fast-pain prediction. The findings could help elucidate the neural mechanism of cross-individual difference in pain experience and the proposed fast-pain prediction scheme could be potentially used as a practical and feasible pain prediction method in clinical practice. PMID:29904336
Multicenter Evaluation of the Accelerate PhenoTest BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis

PubMed Central

2018-01-01

ABSTRACT We describe results from a multicenter study evaluating the Accelerate Pheno system, a first of its kind diagnostic system that rapidly identifies common bloodstream pathogens from positive blood cultures within 90 min and determines bacterial phenotypic antimicrobial susceptibility testing (AST) results within ∼7 h. A combination of fresh clinical and seeded blood cultures were tested, and results from the Accelerate Pheno system were compared to Vitek 2 results for identification (ID) and broth microdilution or disk diffusion for AST. The Accelerate Pheno system accurately identified 14 common bacterial pathogens and two Candida spp. with sensitivities ranging from 94.6 to 100%. Of fresh positive blood cultures, 89% received a monomicrobial call with a positive predictive value of 97.3%. Six common Gram-positive cocci were evaluated for ID. Five were tested against eight antibiotics, two resistance phenotypes (methicillin-resistant Staphylococcus aureus and Staphylococcus spp. [MRSA/MRS]), and inducible clindamycin resistance (MLSb). From the 4,142 AST results, the overall essential agreement (EA) and categorical agreement (CA) were 97.6% and 97.9%, respectively. Overall very major error (VME), major error (ME), and minor error (mE) rates were 1.0%, 0.7%, and 1.3%, respectively. Eight species of Gram-negative rods were evaluated against 15 antibiotics. From the 6,331 AST results, overall EA and CA were 95.4% and 94.3%, respectively. Overall VME, ME, and mE rates were 0.5%, 0.9%, and 4.8%, respectively. The Accelerate Pheno system has the unique ability to identify and provide phenotypic MIC and categorical AST results in a few hours directly from positive blood culture bottles and support accurate antimicrobial adjustment. PMID:29305546
Incongruent genetic connectivity patterns for VME indicator taxa: implications for the management of New Zealand's vulnerable marine ecosystems

NASA Astrophysics Data System (ADS)

Clark, M. R.; Gardner, J.; Holland, L.; Zeng, C.; Hamilton, J. S.; Rowden, A. A.

2016-02-01

In the New Zealand region vulnerable marine ecosystems (VMEs) are at risk from commercial fishing activity and future seabed mining. Understanding connectivity among VMEs is important for the design of effective spatial management strategies, i.e. a network of protected areas. To date however, genetic connectivity in the New Zealand region has rarely been documented. As part of a project developing habitat suitability models and spatial management options for VMEs we used DNA sequence data and microsatellite genotyping to assess genetic connectivity for a range of VME indicator taxa, including the coral Desmophyllum dianthus, and the sponges Poecilastra laminaris and Penares palmatoclada. Overall, patterns of connectivity were inconsistent amonst taxa. Nonetheless, genetic data from each taxon were relevant to inform management at a variety of spatial scales. D. dianthus populations in the Kermadec volcanic arc and the Louisville Seamount Chain were indistinguishable, highlighting the importance of considering source-sink dynamics between populations beyond the EEZ in conservation planning. Poecilastra laminaris populations showed significant divergence across the Chatham Rise, in contrast to P. palmatoclada, which had a uniform haplotypic distribution. However, both sponge species exhibited the highest genetic diversity on the Chatham Rise, suggesting that this area is a genetic hotspot. The spatial heterogeneity of genetic patterns of structure suggest that inclusion of several taxa is necessary to facilitate understanding of regional connectivity patterns, variation in which may be attributed to alternate life history strategies, local hydrodynamic regimes, or in some cases, suboptimal sample sizes. Our findings provide important information for use by environmental managers, including summary maps of genetic diversity and barriers to gene flow, which will be used in spatial management decision-support tools.

Diagnostic Accuracy of Cerebrospinal Fluid Procalcitonin in Bacterial Meningitis Patients with Empiric Antibiotic Pretreatment.

PubMed

Li, Wen; Sun, Xiaolong; Yuan, Fang; Gao, Qiong; Ma, Yue; Jiang, Yongli; Yang, Xiai; Yang, Fang; Ma, Lei; Jiang, Wen

2017-04-01

Accurate diagnosis of bacterial meningitis (BM) relies on cerebrospinal fluid (CSF) Gram staining and bacterial culture, which often present high false-negative rates because of antibiotic abuse. Thus, a novel and reliable diagnostic biomarker is required. Procalcitonin (PCT) has been well demonstrated to be specifically produced from peripheral tissues by bacterial infection, which makes it a potential diagnostic biomarker candidate. Here, we performed a prospective clinical study comprising a total of 143 patients to investigate the diagnostic value of CSF PCT, serum PCT, and other conventional biomarkers for BM. Patients were assigned to the BM ( n = 49), tuberculous meningitis (TBM) ( n = 25), viral meningitis/encephalitis (VM/E) ( n = 34), autoimmune encephalitis (AIE) ( n = 15), or noninflammatory nervous system diseases (NINSD) group ( n = 20). Empirical antibiotic pretreatment was not an exclusion criterion. Our results show that the CSF PCT level was significantly ( P < 0.01) higher in patients with BM (median, 0.22 ng/ml; range, 0.13 to 0.54 ng/ml) than in those with TBM (median, 0.12 ng/ml; range, 0.07 to 0.16 ng/ml), VM/E (median, 0.09 ng/ml; range, 0.07 to 0.11 ng/ml), AIE (median, 0.06 ng/ml; range, 0.05 to 0.10 ng/ml), or NINSD (median, 0.07 ng/ml; range, 0.06 to 0.08 ng/ml). Among the assessed biomarkers, CSF PCT exhibited the largest area under the receiver operating characteristic curve (0.881; 95% confidence interval, 0.810 to 0.932; cutoff value, 0.15 ng/ml; sensitivity, 69.39%; specificity, 91.49%). Our study sheds light upon the diagnostic dilemma of BM due to antibiotic abuse. (This study has been registered at ClinicalTrials.gov under registration no. NCT02278016.). Copyright © 2017 American Society for Microbiology.
Fast modulations of pulsating proton aurora related to subpacket structures of Pc1 geomagnetic pulsations at subauroral latitudes

DOE PAGES

Ozaki, M.; Shiokawa, K.; Miyoshi, Y.; ...

2016-08-16

To understand the role of electromagnetic ion cyclotron (EMIC) waves in determining the temporal features of pulsating proton aurora (PPA) via wave-particle interactions at subauroral latitudes, high-time-resolution (1/8 s) images of proton-induced N 2>+ emissions were recorded using a new electron multiplying charge-coupled device camera, along with related Pc1 pulsations on the ground. The observed Pc1 pulsations consisted of successive rising-tone elements with a spacing for each element of 100 s and subpacket structures, which manifest as amplitude modulations with a period of a few tens of seconds. In accordance with the temporal features of the Pc1 pulsations, the auroralmore » intensity showed a similar repetition period of 100 s and an unpredicted fast modulation of a few tens of seconds. Furthermore, these results indicate that PPA is generated by pitch angle scattering, nonlinearly interacting with Pc1/EMIC waves at the magnetic equator.« less
Thalamic reticular nucleus induces fast and local modulation of arousal state

PubMed Central

Lewis, Laura D; Voigts, Jakob; Flores, Francisco J; Schmitt, L Ian; Wilson, Matthew A

2015-01-01

During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence. Slow waves are locally regulated, and local slow wave dynamics are important for memory, cognition, and behaviour. While several brainstem structures for controlling global sleep states have now been well characterized, a mechanism underlying fast and local modulation of cortical slow waves has not been identified. Here, using optogenetics and whole cortex electrophysiology, we show that local tonic activation of thalamic reticular nucleus (TRN) rapidly induces slow wave activity in a spatially restricted region of cortex. These slow waves resemble those seen in sleep, as cortical units undergo periods of silence phase-locked to the slow wave. Furthermore, animals exhibit behavioural changes consistent with a decrease in arousal state during TRN stimulation. We conclude that TRN can induce rapid modulation of local cortical state. DOI: http://dx.doi.org/10.7554/eLife.08760.001 PMID:26460547
Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

PubMed Central

O'Hare, Justin K; Li, Haofang; Kim, Namsoo; Gaidis, Erin; Ade, Kristen; Beck, Jeff; Yin, Henry

2017-01-01

Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior. PMID:28871960
Fast modulations of pulsating proton aurora related to subpacket structures of Pc1 geomagnetic pulsations at subauroral latitudes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozaki, M.; Shiokawa, K.; Miyoshi, Y.

To understand the role of electromagnetic ion cyclotron (EMIC) waves in determining the temporal features of pulsating proton aurora (PPA) via wave-particle interactions at subauroral latitudes, high-time-resolution (1/8 s) images of proton-induced N 2>+ emissions were recorded using a new electron multiplying charge-coupled device camera, along with related Pc1 pulsations on the ground. The observed Pc1 pulsations consisted of successive rising-tone elements with a spacing for each element of 100 s and subpacket structures, which manifest as amplitude modulations with a period of a few tens of seconds. In accordance with the temporal features of the Pc1 pulsations, the auroralmore » intensity showed a similar repetition period of 100 s and an unpredicted fast modulation of a few tens of seconds. Furthermore, these results indicate that PPA is generated by pitch angle scattering, nonlinearly interacting with Pc1/EMIC waves at the magnetic equator.« less
The effect of fasting during Ramadan on parameters of the haematological and steroidal modules of the athletes biological passport - a pilot study.

PubMed

Alsaadi, K; Voss, S C; Kraiem, S; Alwahaibi, A; Alyazedi, S; Dbes, N; Goebel, R; Mohamed-Ali, V; Alsowaidi, S; Seyam, A M; Bashraheel, A S; Alsayrafi, M; Georgakopoulos, C

2015-01-01

This study investigated the effect of Ramadan on the haematological and steroid module of the Athletes Biological Passport (ABP) of the World Anti-Doping Agency (WADA). Nine healthy physically active subjects were tested in the morning and afternoon for two days before and three days during Ramadan. Sample collection and all analyses were performed according to WADA technical documents. Although there were significant changes in the haemoglobin concentration during Ramadan, especially during the first fasting week, none of the subjects in this study exceeded the individually calculated thresholds of the ABP. No significant effects on testosterone/epitestosterone (T/E) ratio were observed but only the afternoon specific gravity (SG) of the urine was elevated. Thus, when urinary steroid concentrations are required, SG corrections need to be performed. The haematological and the steroid module of the ABP can be reliably applied during Ramadan as the observed changes are only marginal. Copyright © 2015 John Wiley & Sons, Ltd.
Modulation and coding for fast fading mobile satellite communication channels

NASA Technical Reports Server (NTRS)

Mclane, P. J.; Wittke, P. H.; Smith, W. S.; Lee, A.; Ho, P. K. M.; Loo, C.

1988-01-01

The performance of Gaussian baseband filtered minimum shift keying (GMSK) using differential detection in fast Rician fading, with a novel treatment of the inherent intersymbol interference (ISI) leading to an exact solution is discussed. Trellis-coded differentially coded phase shift keying (DPSK) with a convolutional interleaver is considered. The channel is the Rician Channel with the line-of-sight component subject to a lognormal transformation.
Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.

PubMed

Osteen, Jeremiah D; Sampson, Kevin; Iyer, Vivek; Julius, David; Bosmans, Frank

2017-06-27

The Na v 1.1 voltage-gated sodium channel is a critical contributor to excitability in the brain, where pathological loss of function leads to such disorders as epilepsy, Alzheimer's disease, and autism. This voltage-gated sodium (Na v ) channel subtype also plays an important role in mechanical pain signaling by primary afferent somatosensory neurons. Therefore, pharmacologic modulation of Na v 1.1 represents a potential strategy for treating excitability disorders of the brain and periphery. Inactivation is a complex aspect of Na v channel gating and consists of fast and slow components, each of which may involve a contribution from one or more voltage-sensing domains. Here, we exploit the Hm1a spider toxin, a Na v 1.1-selective modulator, to better understand the relationship between these temporally distinct modes of inactivation and ask whether they can be distinguished pharmacologically. We show that Hm1a inhibits the gating movement of the domain IV voltage sensor (VSDIV), hindering both fast and slow inactivation and leading to an increase in Na v 1.1 availability during high-frequency stimulation. In contrast, ICA-121431, a small-molecule Na v 1.1 inhibitor, accelerates a subsequent VSDIV gating transition to accelerate entry into the slow inactivated state, resulting in use-dependent block. Further evidence for functional coupling between fast and slow inactivation is provided by a Na v 1.1 mutant in which fast inactivation removal has complex effects on slow inactivation. Taken together, our data substantiate the key role of VSDIV in Na v channel fast and slow inactivation and demonstrate that these gating processes are sequential and coupled through VSDIV. These findings provide insight into a pharmacophore on VSDIV through which modulation of inactivation gating can inhibit or facilitate Na v 1.1 function.
Pulse-Width-Modulating Driver for Brushless dc Motor

NASA Technical Reports Server (NTRS)

Salomon, Phil M.

1991-01-01

High-current pulse-width-modulating driver for brushless dc motor features optical coupling of timing signals from low-current control circuitry to high-current motor-driving circuitry. Provides high electrical isolation of motor-power supply, helping to prevent fast, high-current motor-driving pulses from being coupled through power supplies into control circuitry, where they interfere with low-current control signals.
Simulation and Spectrum Extraction in the Spectroscopic Channel of the SNAP Experiment

NASA Astrophysics Data System (ADS)

Tilquin, Andre; Bonissent, A.; Gerdes, D.; Ealet, A.; Prieto, E.; Macaire, C.; Aumenier, M. H.

2007-05-01

A pixel-level simulation software is described. It is composed of two modules. The first module applies Fourier optics at each active element of the system to construct the PSF at a large variety of wavelengths and spatial locations of the point source. The input is provided by the engineer's design program (Zemax). It describes the optical path and the distortions. The PSF properties are compressed and interpolated using shapelets decomposition and neural network techniques. A second module is used for production jobs. It uses the output of the first module to reconstruct the relevant PSF and integrate it on the detector pixels. Extended and polychromatic sources are approximated by a combination of monochromatic point sources. For the spectrum extraction, we use a fast simulator based on a multidimensional linear interpolation of the pixel response tabulated on a grid of values of wavelength, position on sky and slice number. The prediction of the fast simulator is compared to the observed pixel content, and a chi-square minimization where the parameters are the bin contents is used to build the extracted spectrum. The visible and infrared arms are combined in the same chi-square, providing a single spectrum.
KSC-2014-2867

NASA Image and Video Library

2014-06-08

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, the Orion service module has been secured in the Final Assembly and System Testing, or FAST, cell. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2866

NASA Image and Video Library

2014-06-08

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, the Orion service module has been secured in the Final Assembly and System Testing, or FAST, cell. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
Multiple components of surround modulation in primary visual cortex: multiple neural circuits with multiple functions?

PubMed Central

Nurminen, Lauri; Angelucci, Alessandra

2014-01-01

The responses of neurons in primary visual cortex (V1) to stimulation of their receptive field (RF) are modulated by stimuli in the RF surround. This modulation is suppressive when the stimuli in the RF and surround are of similar orientation, but less suppressive or facilitatory when they are cross-oriented. Similarly, in human vision surround stimuli selectively suppress the perceived contrast of a central stimulus. Although the properties of surround modulation have been thoroughly characterized in many species, cortical areas and sensory modalities, its role in perception remains unknown. Here we argue that surround modulation in V1 consists of multiple components having different spatio-temporal and tuning properties, generated by different neural circuits and serving different visual functions. One component arises from LGN afferents, is fast, untuned for orientation, and spatially restricted to the surround region nearest to the RF (the near-surround); its function is to normalize V1 cell responses to local contrast. Intra-V1 horizontal connections contribute a slower, narrowly orientation-tuned component to near-surround modulation, whose function is to increase the coding efficiency of natural images in manner that leads to the extraction of object boundaries. The third component is generated by topdown feedback connections to V1, is fast, broadly orientation-tuned, and extends into the far-surround; its function is to enhance the salience of behaviorally relevant visual features. Far- and near-surround modulation, thus, act as parallel mechanisms: the former quickly detects and guides saccades/attention to salient visual scene locations, the latter segments object boundaries in the scene. PMID:25204770
Artifacts in time-resolved Kelvin probe force microscopy

DOE PAGES

Sadewasser, Sascha; Nicoara, Nicoleta; Solares, Santiago D.

2018-04-24

Kelvin probe force microscopy (KPFM) has been used for the characterization of metals, insulators, and semiconducting materials on the nanometer scale. Especially in semiconductors, the charge dynamics are of high interest. Recently, several techniques for time-resolved measurements with time resolution down to picoseconds have been developed, many times using a modulated excitation signal, e.g. light modulation or bias modulation that induces changes in the charge carrier distribution. For fast modulation frequencies, the KPFM controller measures an average surface potential, which contains information about the involved charge carrier dynamics. Here, we show that such measurements are prone to artifacts due tomore » frequency mixing, by performing numerical dynamics simulations of the cantilever oscillation in KPFM subjected to a bias-modulated signal. For square bias pulses, the resulting time-dependent electrostatic forces are very complex and result in intricate mixing of frequencies that may, in some cases, have a component at the detection frequency, leading to falsified KPFM measurements. Additionally, we performed fast Fourier transform (FFT) analyses that match the results of the numerical dynamics simulations. Small differences are observed that can be attributed to transients and higher-order Fourier components, as a consequence of the intricate nature of the cantilever driving forces. These results are corroborated by experimental measurements on a model system. In the experimental case, additional artifacts are observed due to constructive or destructive interference of the bias modulation with the cantilever oscillation. Also, in the case of light modulation, we demonstrate artifacts due to unwanted illumination of the photodetector of the beam deflection detection system. Lastly, guidelines for avoiding such artifacts are given.« less
Artifacts in time-resolved Kelvin probe force microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sadewasser, Sascha; Nicoara, Nicoleta; Solares, Santiago D.

Kelvin probe force microscopy (KPFM) has been used for the characterization of metals, insulators, and semiconducting materials on the nanometer scale. Especially in semiconductors, the charge dynamics are of high interest. Recently, several techniques for time-resolved measurements with time resolution down to picoseconds have been developed, many times using a modulated excitation signal, e.g. light modulation or bias modulation that induces changes in the charge carrier distribution. For fast modulation frequencies, the KPFM controller measures an average surface potential, which contains information about the involved charge carrier dynamics. Here, we show that such measurements are prone to artifacts due tomore » frequency mixing, by performing numerical dynamics simulations of the cantilever oscillation in KPFM subjected to a bias-modulated signal. For square bias pulses, the resulting time-dependent electrostatic forces are very complex and result in intricate mixing of frequencies that may, in some cases, have a component at the detection frequency, leading to falsified KPFM measurements. Additionally, we performed fast Fourier transform (FFT) analyses that match the results of the numerical dynamics simulations. Small differences are observed that can be attributed to transients and higher-order Fourier components, as a consequence of the intricate nature of the cantilever driving forces. These results are corroborated by experimental measurements on a model system. In the experimental case, additional artifacts are observed due to constructive or destructive interference of the bias modulation with the cantilever oscillation. Also, in the case of light modulation, we demonstrate artifacts due to unwanted illumination of the photodetector of the beam deflection detection system. Lastly, guidelines for avoiding such artifacts are given.« less
Amplitude Modulator Chassis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erbert, G

2009-09-01

The Amplitude Modulator Chassis (AMC) is the final component in the MOR system and connects directly to the PAM input through a 100-meter fiber. The 48 AMCs temporally shape the 48 outputs of the MOR using an arbitrary waveform generator coupled to an amplitude modulator. The amplitude modulation element is a two stage, Lithium Niobate waveguide device, where the intensity of the light passing through the device is a function of the electrical drive applied. The first stage of the modulator is connected to a programmable high performance Arbitrary Waveform Generator (AWG) consisting of 140 impulse generators space 250 psmore » apart. An arbitrary waveform is generated by independently varying the amplitude of each impulse generator and then summing the impulses together. In addition to the AWG a short pulse generator is also connected to the first stage of the modulator to provide a sub 100-ps pulse used for timing experiments. The second stage of the modulator is connect to a square pulse generator used to further attenuate any pre or post pulse light passing through the first stage of the modulator. The fast rise and fall time of the square pulse generator is also used to produce fast rise and fall times of the AWG by clipping the AWG pulse. For maximum extinction, a pulse bias voltage is applied to each stage of the modulator. A pulse voltage is applied as opposed to a DC voltage to prevent charge buildup on the modulator. Each bias voltage is adjustable to provide a minimum of 50-dB extinction. The AMC is controlled through ICCS to generate the desired temporal pulse shape. This process involves a closed-loop control algorithm, which compares the desired temporal waveform to the produced optical pulse, and iterates the programming of the AWG until the two waveforms agree within an allowable tolerance.« less
Instrument front-ends at Fermilab during Run II

NASA Astrophysics Data System (ADS)

Meyer, T.; Slimmer, D.; Voy, D.

2011-11-01

The optimization of an accelerator relies on the ability to monitor the behavior of the beam in an intelligent and timely fashion. The use of processor-driven front-ends allowed for the deployment of smart systems in the field for improved data collection and analysis during Run II. This paper describes the implementation of the two main systems used: National Instruments LabVIEW running on PCs, and WindRiver's VxWorks real-time operating system running in a VME crate processor. Work supported by Fermi Research Alliance, LLC under Contract No. DE-AC02-07CH11359 with the United States Department of Energy.
NAS (HOST/ARTS IIIA) to VME Modem Interface ATC Interface Hardware Manual

DTIC Science & Technology

1990-10-01

SIXT,RXSYNC,RXACTIVE,ALLOWI) IO,C,0,1,O,O1 - > [^bf,1,1,O,0J;vector 104 [o,c,0,1,o,0J -> [^hf,1,1,O,OJ;vector [I,C,0,1,O,0] -> [Abf,1,1,0,OJ;vector IO,C...VFU.T(R 501 C’-35 Io,c,1,1,o,o,o1 -> rhb ,0,01;i [X,C,1,1,0,O,1] -> ["hf,0,0; [1,C,1,I,0,1,01 -> [^ha,0,1];LACT (MTE)-S2 io,C,,1,0,1,01 -> I^ha,0,1; [1
AdA Compiler Validation Summary Report: Certificate Number: 910920W1. 11214 Verdix Corporation, VADS VAX VMS= AMD 29K, VAda-110-03525, Version 6.04, MicroVAX 3600 (Host) to Ironics IV9001 Board (Target). MVME147 (Target)

DTIC Science & Technology

1991-09-20

Agreement Number: 91-07-16- VRX See section 3.1 for any additional information about the testing environment. As a result of this validation effort...Washington DC 20301 92-06991 AVF Control Number: AVF-VSR-511.0292 18 February 1992 91-07-16- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number...System: Ironics IV9001 board (AMD 29000) (Am29000 bare VME machine) Customer Agreement Number: 91-07-16- VRX See section 3.1 for any additional information
Front-end electronics and DAQ for the EURITRACK tagged neutron inspection system

NASA Astrophysics Data System (ADS)

Lunardon, M.; Bottosso, C.; Fabris, D.; Moretto, S.; Nebbia, G.; Pesente, S.; Viesti, G.; Bigongiari, A.; Colonna, A.; Tintori, C.; Valkovic, V.; Sudac, D.; Peerani, P.; Sequeira, V.; Salvato, M.

2007-08-01

The EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) Front-End and Data Acquisition System is a compact set of VME boards interfaced with a standard PC. The system is part of a cargo container inspection portal based on the tagged neutrons technique. The front-end processes all detector signals and checks coincidences between any of the 64 pixels of the alpha particle detector and any gamma-ray signals in 22 NaI(Tl) scintillators. The system is capable of handling the data flow at neutron flux up to the portal limiting value of 108 neutrons/second. Some typical applications are presented.

AeroDyn V15.04: Design tool for wind and MHK turbines

DOE Data Explorer

Murray, Robynne; Hayman, Greg; Jonkman, Jason

2017-04-28

AeroDyn is a time-domain wind and MHK turbine aerodynamics module that can be coupled into the FAST version 8 multi-physics engineering tool to enable aero-elastic simulation of horizontal-axis wind turbines. AeroDyn V15.04 has been updated to include a cavitation check for MHK turbines, and can be driven as a standalone code to compute wind turbine aerodynamic response uncoupled from FAST. Note that while AeroDyn has been updated to v15.04, FAST v8.16 has not yet been updated and still uses AeroDyn v15.03.
Synergy between fast-ion transport by core MHD and test blanket module fields in DIII-D experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heidbrink, W. W.; Austin, M. E.; Collins, C. S.

2015-07-21

We measured fast-ion transport caused by the combination of MHD and a mock-up test-blanket module (TBM) coil in the DIII-D tokamak. The primary diagnostic is an infrared camera that measures the heat flux on the tiles surrounding the coil. The combined effects of the TBM and four other potential sources of transport are studied: neoclassical tearing modes, Alfvén eigenmodes, sawteeth, and applied resonant magnetic perturbation fields for the control of edge localized modes. A definitive synergistic effect is observed at sawtooth crashes where, in the presence of the TBM, the localized heat flux at a burst increases from 0.36 ±0.27more » to 2.6 ±0.5 MW/m -2.« less
Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simarro, Maria; Gimenez-Cassina, Alfredo; Kedersha, Nancy

2010-10-22

Research highlights: {yields} Five members of the FAST kinase domain-containing proteins are localized to mitochondria in mammalian cells. {yields} The FASTKD3 interactome includes proteins involved in various aspects of mitochondrial metabolism. {yields} Targeted knockdown of FASTKD3 significantly reduces basal and maximal mitochondrial oxygen consumption. -- Abstract: Fas-activated serine/threonine phosphoprotein (FAST) is the founding member of the FAST kinase domain-containing protein (FASTKD) family that includes FASTKD1-5. FAST is a sensor of mitochondrial stress that modulates protein translation to promote the survival of cells exposed to adverse conditions. Mutations in FASTKD2 have been linked to a mitochondrial encephalomyopathy that is associated withmore » reduced cytochrome c oxidase activity, an essential component of the mitochondrial electron transport chain. We have confirmed the mitochondrial localization of FASTKD2 and shown that all FASTKD family members are found in mitochondria. Although human and mouse FASTKD1-5 genes are expressed ubiquitously, some of them are most abundantly expressed in mitochondria-enriched tissues. We have found that RNA interference-mediated knockdown of FASTKD3 severely blunts basal and stress-induced mitochondrial oxygen consumption without disrupting the assembly of respiratory chain complexes. Tandem affinity purification reveals that FASTKD3 interacts with components of mitochondrial respiratory and translation machineries. Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration.« less
Determination of chlorine concentration using single temperature modulated semiconductor gas sensor

NASA Astrophysics Data System (ADS)

Woźniak, Ł.; Kalinowski, P.; Jasiński, G.; Jasiński, P.

2016-11-01

A periodic temperature modulation using sinusoidal heater voltage was applied to a commercial SnO2 semiconductor gas sensor. Resulting resistance response of the sensor was analyzed using a feature extraction method based on Fast Fourier Transformation (FFT). The amplitudes of the higher harmonics of the FFT from the dynamic nonlinear responses of measured gas were further utilized as an input for Artificial Neuron Network (ANN). Determination of the concentration of chlorine was performed. Moreover, this work evaluates the sensor performance upon sinusoidal temperature modulation.
Thomson Scattering Diagnostic Data Acquisition Systems for Modern Fusion Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ivanenko, S.V.; Khilchenko, A.D.; Ovchar, V.K.

2015-07-01

Uniquely designed complex data acquisition system for Thomson scattering diagnostic was developed. It allows recording short duration (3-5 ns) scattered pulses with 2 GHz sampling rate and 10-bit total resolution in oscilloscope mode. The system consists up to 48 photo detector modules with 0- 200 MHz bandwidth, 1-48 simultaneously sampling ADC modules and synchronization subsystem. The photo detector modules are based on avalanche photodiodes (APD) and ultra-low noise trans-impedance amplifiers. ADC modules include fast analog to digital converters and digital units based on the FPGA (Field- Programmable Gate Array) for data processing and storage. The synchronization subsystem is used tomore » form triggering pulses and to organize the simultaneously mode of ADC modules operation. (authors)« less
Retro-modulators and fast beam steering for free-space optical communications

NASA Astrophysics Data System (ADS)

Chan, Trevor Keith

Free-space optical (FSO) communications is a means of secure, high bandwidth communication through the use of a modulated laser beam in free-space as the information medium. The chaotic nature of the atmosphere and the motion of the communication nodes make laser alignment a crucial concern. The employment of retro-reflecting modulators makes the bidirectional quality of a communication link into a one sided alignment problem. While there are existing retro-reflecting modulators, their trade-offs create a lack of abilities (such as aperture size, angular range, high modulation speeds, economic viability) which do not fulfill the requirements for certain applications. Also, the beam must be directed towards the intended receiver. Form mobile or scintillated communication links, beam direction must be adaptable in real time. Once again, this area suffers from trade-offs where beamsteering speed is often limited. Research used to mitigate the trade-offs and adapt the devices into viable options for a wider range of applications is explored in this dissertation. Two forms of retro-modulators were explored; a MEMS deformable mirror retro-modulator and a solid silicon retro-modulator that modulated the light by frustrated total internal reflection (FTIR). The MEMS version offered a high speed, scalable, wavelength/angle insensitive retro-modulator which can be massed produced at low cost, while the solid retro-modulator offered a large field of view with low cost as well. Both modulator's design, simulated performances, fabrication and experimental characterization are described in this dissertation. An ultra-fast beamscanner was also designed using 2-dimensional dispersion. By using wavelength switching for directional control, a beamscanner was developed that could switch light faster than pre-existing beamscanners while the beams characteristics (most importantly its aperture) could be freely adjusted by the independent optics. This beamscanner was preceded by our work on a large channel wavelength demultiplexer which combined two orthogonally oriented wavelength demultiplexers. This created a 2-dimensional array of spots in free-space. The light was directed be a collimating lens into a specific direction based on its wavelength. The performance of this beamscanner was simulated by modeling the dispersive properties of the components.
Do we need 3D tube current modulation information for accurate organ dosimetry in chest CT? Protocols dose comparisons.

PubMed

Lopez-Rendon, Xochitl; Zhang, Guozhi; Coudyzer, Walter; Develter, Wim; Bosmans, Hilde; Zanca, Federica

2017-11-01

To compare the lung and breast dose associated with three chest protocols: standard, organ-based tube current modulation (OBTCM) and fast-speed scanning; and to estimate the error associated with organ dose when modelling the longitudinal (z-) TCM versus the 3D-TCM in Monte Carlo simulations (MC) for these three protocols. Five adult and three paediatric cadavers with different BMI were scanned. The CTDI vol of the OBTCM and the fast-speed protocols were matched to the patient-specific CTDI vol of the standard protocol. Lung and breast doses were estimated using MC with both z- and 3D-TCM simulated and compared between protocols. The fast-speed scanning protocol delivered the highest doses. A slight reduction for breast dose (up to 5.1%) was observed for two of the three female cadavers with the OBTCM in comparison to the standard. For both adult and paediatric, the implementation of the z-TCM data only for organ dose estimation resulted in 10.0% accuracy for the standard and fast-speed protocols, while relative dose differences were up to 15.3% for the OBTCM protocol. At identical CTDI vol values, the standard protocol delivered the lowest overall doses. Only for the OBTCM protocol is the 3D-TCM needed if an accurate (<10.0%) organ dosimetry is desired. • The z-TCM information is sufficient for accurate dosimetry for standard protocols. • The z-TCM information is sufficient for accurate dosimetry for fast-speed scanning protocols. • For organ-based TCM schemes, the 3D-TCM information is necessary for accurate dosimetry. • At identical CTDI vol , the fast-speed scanning protocol delivered the highest doses. • Lung dose was higher in XCare than standard protocol at identical CTDI vol .
Frequency of gamma oscillations in humans is modulated by velocity of visual motion

PubMed Central

Butorina, Anna V.; Sysoeva, Olga V.; Prokofyev, Andrey O.; Nikolaeva, Anastasia Yu.; Stroganova, Tatiana A.

2015-01-01

Gamma oscillations are generated in networks of inhibitory fast-spiking (FS) parvalbumin-positive (PV) interneurons and pyramidal cells. In animals, gamma frequency is modulated by the velocity of visual motion; the effect of velocity has not been evaluated in humans. In this work, we have studied velocity-related modulations of gamma frequency in children using MEG/EEG. We also investigated whether such modulations predict the prominence of the “spatial suppression” effect (Tadin D, Lappin JS, Gilroy LA, Blake R. Nature 424: 312-315, 2003) that is thought to depend on cortical center-surround inhibitory mechanisms. MEG/EEG was recorded in 27 normal boys aged 8–15 yr while they watched high-contrast black-and-white annular gratings drifting with velocities of 1.2, 3.6, and 6.0°/s and performed a simple detection task. The spatial suppression effect was assessed in a separate psychophysical experiment. MEG gamma oscillation frequency increased while power decreased with increasing velocity of visual motion. In EEG, the effects were less reliable. The frequencies of the velocity-specific gamma peaks were 64.9, 74.8, and 87.1 Hz for the slow, medium, and fast motions, respectively. The frequency of the gamma response elicited during slow and medium velocity of visual motion decreased with subject age, whereas the range of gamma frequency modulation by velocity increased with age. The frequency modulation range predicted spatial suppression even after controlling for the effect of age. We suggest that the modulation of the MEG gamma frequency by velocity of visual motion reflects excitability of cortical inhibitory circuits and can be used to investigate their normal and pathological development in the human brain. PMID:25925324
Phase control and fast start-up of a magnetron using modulation of an addressable faceted cathode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Browning, J., E-mail: JimBrowning@BoiseState.edu; Fernandez-Gutierrez, S.; Lin, M. C.

The use of an addressable, faceted cathode has been proposed as a method of modulating current injection in a magnetron to improve performance and control phase. To implement the controllable electron emission, five-sided and ten-sided faceted planar cathodes employing gated field emitters are considered as these emitters could be fabricated on flat substrates. For demonstration, the conformal finite-difference time-domain particle-in-cell simulation, as implemented in VORPAL, has been used to model a ten-cavity, rising sun magnetron using the modulated current sources and benchmarked against a typical continuous current source. For the modulated, ten-sided faceted cathode case, the electrons are injected frommore » three emitter elements on each of the ten facets. Each emitter is turned ON and OFF in sequence at the oscillating frequency with five emitters ON at one time to drive the five electron spokes of the π-mode. The emitter duty cycle is then 1/6th the Radio-Frequency (RF) period. Simulations show a fast start-up time as low as 35 ns for the modulated case compared to 100 ns for the continuous current cases. Analysis of the RF phase using the electron spoke locations and the RF magnetic field components shows that the phase is controlled for the modulated case while it is random, as typical, for the continuous current case. Active phase control during oscillation was demonstrated by shifting the phase of the electron injection 180° after oscillations started. The 180° phase shift time was approximately 25 RF cycles.« less
The Modulation of Exogenous Spatial Cueing on Spatial Stroop Interference: Evidence of a Set for "Cue-Target Event Segregation"

ERIC Educational Resources Information Center

Funes, Maria Jesus; Lupianez, Juan; Milliken, Bruce

2008-01-01

Two experiments are reported that test whether the modulation of exogenous cuing effects by the presence of a distractor at the location opposite the target (altering the time course of cueing effects, Lupianez et al., 1999, 2001) is due to the fast reorienting of attention or to a set for preventing the integration of the cue and the target…
Experimental Performance of a Single-Mode Ytterbium-doped Fiber Ring Laser with Intracavity Modulator

NASA Technical Reports Server (NTRS)

Numata, Kenji; Camp, Jordan

2012-01-01

We have developed a linearly polarized Ytterbium-doped fiber ring laser with a single longitudinal mode output at 1064 run. A fiber-coupled intracavity phase modulator ensured mode-hop free operation and allowed fast frequency tuning. The fiber laser was locked with high stability to an iodine-stabilized laser, showing a frequency noise suppression of a factor approx 10 (exp 5) at 1 mHz
"Flash" dance: how speed modulates percieved duration in dancers and non-dancers.

PubMed

Sgouramani, Helena; Vatakis, Argiro

2014-03-01

Speed has been proposed as a modulating factor on duration estimation. However, the different measurement methodologies and experimental designs used have led to inconsistent results across studies, and, thus, the issue of how speed modulates time estimation remains unresolved. Additionally, no studies have looked into the role of expertise on spatiotemporal tasks (tasks requiring high temporal and spatial acuity; e.g., dancing) and susceptibility to modulations of speed in timing judgments. In the present study, therefore, using naturalistic, dynamic dance stimuli, we aimed at defining the role of speed and the interaction of speed and experience on time estimation. We presented videos of a dancer performing identical ballet steps in fast and slow versions, while controlling for the number of changes present. Professional dancers and non-dancers performed duration judgments through a production and a reproduction task. Analysis revealed a significantly larger underestimation of fast videos as compared to slow ones during reproduction. The exact opposite result was true for the production task. Dancers were significantly less variable in their time estimations as compared to non-dancers. Speed and experience, therefore, affect the participants' estimates of time. Results are discussed in association to the theoretical framework of current models by focusing on the role of attention. © 2013 Elsevier B.V. All rights reserved.
KSC-2014-2863

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin engineers and technicians monitor the progress as a crane lowers the Orion service module into the Final Assembly and System Testing, or FAST, cell. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2855

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin technicians and engineers prepare to move the Orion service module to the Final Assembly and System Testing, or FAST, cell further down the aisle. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, prior to rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2862

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, a Lockheed Martin technician monitors the progress as a crane lowers the Orion service module into the Final Assembly and System Testing, or FAST, cell further down the aisle. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2860

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin engineers and technicians help guide the Orion service module into the Final Assembly and System Testing, or FAST, cell. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2861

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin engineers and technicians monitor the progress as a crane lowers the Orion service module into the Final Assembly and System Testing, or FAST, cell. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
A CAMAC display module for fast bit-mapped graphics

NASA Astrophysics Data System (ADS)

Abdel-Aal, R. E.

1992-10-01

In many data acquisition and analysis facilities for nuclear physics research, utilities for the display of two-dimensional (2D) images and spectra on graphics terminals suffer from low speed, poor resolution, and limited accuracy. Development of CAMAC bit-mapped graphics modules for this purpose has been discouraged in the past by the large device count needed and the long times required to load the image data from the host computer into the CAMAC hardware; particularly since many such facilities have been designed to support fast DMA block transfers only for data acquisition into the host. This paper describes the design and implementation of a prototype CAMAC graphics display module with a resolution of 256×256 pixels at eight colours for which all components can be easily accommodated in a single-width package. Employed is a hardware technique which reduces the number of programmed CAMAC data transfer operations needed for writing 2D images into the display memory by approximately an order of magnitude, with attendant improvements in the display speed and CPU time consumption. Hardware and software details are given together with sample results. Information on the performance of the module in a typical VAX/MBD data acquisition environment is presented, including data on the mutual effects of simultaneous data acquisition traffic. Suggestions are made for further improvements in performance.
Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goetz, R.; Dover, K; Laezza, F

2009-01-01

Voltage-gated sodium channels (Nav) produce sodium currents that underlie the initiation and propagation of action potentials in nerve and muscle cells. Fibroblast growth factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Nav alpha subunit to modulate fast inactivation of the channel. In this study we solved the crystal structure of a 149-residue-long fragment of human FHF2A which unveils the structural features of the homology core domain of all 10 human FHF isoforms. Through analysis of crystal packing contacts and site-directed mutagenesis experiments we identified a conserved surface on the FHF core domain that mediates channel bindingmore » in vitro and in vivo. Mutations at this channel binding surface impaired the ability of FHFs to co-localize with Navs at the axon initial segment of hippocampal neurons. The mutations also disabled FHF modulation of voltage-dependent fast inactivation of sodium channels in neuronal cells. Based on our data, we propose that FHFs constitute auxiliary subunits for Navs.« less
MMPP Traffic Generator for the Testing of the SCAR 2 Fast Packet Switch

NASA Technical Reports Server (NTRS)

Chren, William A., Jr.

1995-01-01

A prototype MWP Traffic Generator (TG) has been designed for testing of the COMSAT-supplied SCAR II Fast Packet Switch. By generating packets distributed according to a Markov-Modulated Poisson Process (MMPP) model. it allows the assessment of the switch performance under traffic conditions that are more realistic than could be generated using the COMSAT-supplied Traffic Generator Module. The MMPP model is widely believed to model accurately real-world superimposed voice and data communications traffic. The TG was designed to be as much as possible of a "drop-in" replacement for the COMSAT Traffic Generator Module. The latter fit on two Altera EPM7256EGC 192-pin CPLDs and produced traffic for one switch input port. No board changes are necessary because it has been partitioned to use the existing board traces. The TG, consisting of parts "TGDATPROC" and "TGRAMCTL" must merely be reprogrammed into the Altera devices of the same name. However, the 040 controller software must be modified to provide TG initialization data. This data will be given in Section II.

Unconventional ligands and modulators of nicotinic receptors.

PubMed

Pereira, Edna F R; Hilmas, Corey; Santos, Mariton D; Alkondon, Manickavasagom; Maelicke, Alfred; Albuquerque, Edson X

2002-12-01

Evidence gathered from epidemiologic and behavioral studies have indicated that neuronal nicotinic receptors (nAChRs) are intimately involved in the pathogenesis of a number of neurologic disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. In the mammalian brain, neuronal nAChRs, in addition to mediating fast synaptic transmission, modulate fast synaptic transmission mediated by the major excitatory and inhibitory neurotransmitters glutamate and GABA, respectively. Of major interest, however, is the fact that the activity of the different subtypes of neuronal nAChR is also subject to modulation by substances of endogenous origin such as choline, the tryptophan metabolite kynurenic acid, neurosteroids, and beta-amyloid peptides and by exogenous substances, including the so-called nicotinic allosteric potentiating ligands, of which galantamine is the prototype, and psychotomimetic drugs such as phencyclidine and ketamine. The present article reviews and discusses the effects of unconventional ligands on nAChR activity and briefly describes the potential benefits of using some of these compounds in the treatment of neuropathologic conditions in which nAChR function/expression is known to be altered. Copyright 2002 Wiley Periodicals, Inc.
Association between proximity to and coverage of traditional fast-food restaurants and non-traditional fast-food outlets and fast-food consumption among rural adults

PubMed Central

2011-01-01

Objective The objective of this study is to examine the relationship between residential exposure to fast-food entrées, using two measures of potential spatial access: proximity (distance to the nearest location) and coverage (number of different locations), and weekly consumption of fast-food meals. Methods Traditional fast-food restaurants and non-traditional fast-food outlets, such as convenience stores, supermarkets, and grocery stores, from the 2006 Brazos Valley Food Environment Project were linked with individual participants (n = 1409) who completed the nutrition module in the 2006 Brazos Valley Community Health Assessment. Results Increased age, poverty, increased distance to the nearest fast food, and increased number of different traditional fast-food restaurants, non-traditional fast-food outlets, or fast-food opportunities were associated with less frequent weekly consumption of fast-food meals. The interaction of gender and proximity (distance) or coverage (number) indicated that the association of proximity to or coverage of fast-food locations on fast-food consumption was greater among women and opposite of independent effects. Conclusions Results provide impetus for identifying and understanding the complex relationship between access to all fast-food opportunities, rather than to traditional fast-food restaurants alone, and fast-food consumption. The results indicate the importance of further examining the complex interaction of gender and distance in rural areas and particularly in fast-food consumption. Furthermore, this study emphasizes the need for health promotion and policy efforts to consider all sources of fast-food as part of promoting healthful food choices. PMID:21599955
[Hunger-driven modulation in brain functions].

PubMed

Hirano, Yukinori; Saitoe, Minoru

2014-01-01

\\All organisms must obtain nutrition in order to survive and produce their progeny. In the natural environment, however, adequate nutrition or food is not always available. Thus, all organisms are equipped with mechanisms by which their nutritional condition alters their internal activities. In animals, the loss of nutritional intake (fasting) alters not only metabolism, but also behavior in a manner dependent on hormones such as insulin, glucagon, leptin, and ghrelin. As a result, animals are able to maintain their blood sugar level, and are motivated to crave food upon fasting. Moreover, our recent study revealed a novel role of hunger, which facilitates long-term memory (LTM) formation, and its molecular mechanism in the fruit fly, Drosophila. Here, we review the overall effect of fasting, and how fasting affects brain function. I then introduce our finding in which mild fasting facilitates LTM formation, and discuss its biological significance.
A new strategy for fast radiofrequency CW EPR imaging: Direct detection with rapid scan and rotating gradients

PubMed Central

Subramanian, Sankaran; Koscielniak, Janusz W.; Devasahayam, Nallathamby; Pursley, Randall H.; Pohida, Thomas J.; Krishna, Murali C.

2007-01-01

Rapid field scan on the order of T/s using high frequency sinusoidal or triangular sweep fields superimposed on the main Zeeman field, was used for direct detection of signals without low-frequency field modulation. Simultaneous application of space-encoding rotating field gradients have been employed to perform fast CW EPR imaging using direct detection that could, in principle, approach the speed of pulsed FT EPR imaging. The method takes advantage of the well-known rapid-scan strategy in CW NMR and EPR that allows arbitrarily fast field sweep and the simultaneous application of spinning gradients that allows fast spatial encoding. This leads to fast functional EPR imaging and, depending on the spin concentration, spectrometer sensitivity and detection band width, can provide improved temporal resolution that is important to interrogate dynamics of spin perfusion, pharmacokinetics, spectral spatial imaging, dynamic oxymetry, etc. PMID:17350865
Studying Solar Wind Properties Around CIRs and Their Effects on GCR Modulation

NASA Astrophysics Data System (ADS)

Ghanbari, K.; Florinski, V. A.

2017-12-01

Corotating interaction region (CIR) events occur when a fast solar wind stream overtakes slow solar wind, forming a compression region ahead and a rarefaction region behind in the fast solar wind. Usually this phenomena occurs along with a crossing of heliospheric current sheet which is the surface separating solar magnetic fields of opposing polarities. In this work, the solar plasma data provided by the ACE science center are utilized to do a superposed epoch analysis on solar parameters including proton density, proton temperature, solar wind speed and solar magnetic field in order to study how the variations of these parameters affect the modulation of galactic cosmic rays. Magnetic fluctuation variances in different parts a of CIR are computed and analyzed using similar techniques in order to understand the cosmic-ray diffusive transport in these regions.
Design and Testing of a Fast, 50 kV Solid-State Kicker Pulser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, E G; Hickman, B C; Lee, B S

2002-06-24

The ability to extract particle beam bunches from a ring accelerator in arbitrary order can greatly extend an accelerator's capabilities and applications. A prototype solid-state kicker pulser capable of generating asynchronous bursts of 50 kV pulses has been designed and tested into a 50{Omega} load. The pulser features fast rise and fall times and is capable of generating an arbitrary pattern of pulses with a maximum burst frequency exceeding 5 MHz If required, the pulse-width of each pulse in the burst is independently adjustable. This kicker modulator uses multiple solid-state modules stacked in an inductive-adder configuration where the energy ismore » switched into each section of the adder by a parallel array of MOSFETs. Test data, capabilities, and limitations of the prototype pulser are described.« less
Modulation of synaptic transmission in the rabbit coeliac ganglia by gastric and duodenal mechanoreceptors.

PubMed

Mazet, B; Miolan, J P; Niel, J P; Julé, Y; Roman, C

1989-01-01

The involvement of duodenal and gastric mechanoreceptors in the modulation of synaptic transmission was investigated in a rabbit sympathetic prevertebral ganglion. The present study was performed in vitro on the coeliac plexus connected to the stomach and the duodenum. The electrical activity of ganglionic neurons was recorded using intracellular recording techniques. The patterns of synaptic activation of these ganglionic neurons in response to the activation of mechanoreceptors by gastric or duodenal distension were investigated. Although gastric or duodenal distension was unable to elicit any fast synaptic activity in ganglionic neurons, it produced either an inhibition or a facilitation of the fast nicotinic excitatory postsynaptic potentials elicited by stimulation of the thoracic splanchnic nerves. In addition, this distension triggered long-lasting (3-11 min) modifications in the electrical properties of the ganglionic neurons, i.e. slow depolarizations (6-18 mV) or slow hyperpolarizations (3-6 mV), which were sometimes associated with a decrease in the input membrane resistance. After cooling of the nerves connecting the coeliac ganglia to the stomach, the activation of gastric or duodenal mechanoreceptors was no longer able to modify the fast synaptic activation or the electrical properties of the ganglionic neurons. The results demonstrate that gastric and duodenal mechanoreceptors project onto neurons of the coeliac ganglia and change their excitability as well as the central inputs they receive. The long duration of these modifications suggests that gastric and duodenal mechanoreceptors can modulate the activity of the neurons of the coeliac ganglia.
Leptin inhibits testosterone secretion from adult rat testis in vitro.

PubMed

Tena-Sempere, M; Pinilla, L; González, L C; Diéguez, C; Casanueva, F F; Aguilar, E

1999-05-01

Leptin, the product of the ob gene, has emerged recently as a pivotal signal in the regulation of fertility. Although the actions of leptin in the control of reproductive function are thought to be exerted mainly at the hypothalamic level, the potential direct effects of leptin at the pituitary and gonadal level have been poorly characterised. In the present study, we first assessed the ability of leptin to regulate testicular testosterone secretion in vitro. Secondly, we aimed to evaluate whether leptin can modulate basal gonadotrophin and prolactin (PRL) release by incubated hemi-pituitaries from fasted male rats. To attain the first goal, testicular slices from prepubertal and adult rats were incubated with increasing concentrations (10(-9)-10(-7) M) of recombinant leptin. Assuming that in vitro testicular responsiveness to leptin may be dependent on the background leptin levels, testicular tissue from both food-deprived and normally-fed animals was used. Furthermore, leptin modulation of stimulated testosterone secretion was evaluated by incubation of testicular samples with different doses of leptin in the presence of 10 IU human chorionic gonadotrophin (hCG). In addition, analysis of leptin actions on pituitary function was carried out using hemi-pituitaries from fasted adult male rats incubated in the presence of increasing concentrations (10(-9)-10(-7) M) of recombinant leptin. Serum testosterone levels, and basal and hCG-stimulated testosterone secretion by incubated testicular tissue were significantly decreased by fasting in prepubertal and adult male rats. However, a significant reduction in circulating LH levels was only evident in adult fasted rats. Doses of 10(-9)-10(-7) M leptin had no effect on basal or hCG-stimulated testosterone secretion by testes from prepubertal rats, regardless of the nutritional state of the donor animal. In contrast, leptin significantly decreased basal and hCG-induced testosterone secretion by testes from fasted and fed adult rats. In addition, 10(-9) M leptin inhibited LH and FSH secretion by incubated hemi-pituitaries from fasted adult males, whereas, at all doses tested, it was ineffective in modulating PRL release. Our results show that leptin, depending on the state of sexual maturation, is able to inhibit testosterone secretion acting at the testicular level. Furthermore, the present data suggest that the actions of leptin on the reproductive system are complex and are probably carried out at different levels of the hypothalamic-pituitary-gonadal axis.
The K{sub a}-band 10-kW continuous wave gyrotron with wide-band fast frequency sweep

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glyavin, M.; Luchinin, A.; Morozkin, M.

2012-07-15

The dual-frequency gyrotron with fast 2% frequency sweep at about 28 GHz is designed to power an electron cyclotron resonance ion source (ECRIS). Operation with an output power of up to 10 kW in CW mode and efficiency of 20% was demonstrated at both frequencies. Frequency manipulation has a characteristic time of about 1 ms and is based on magnetic field variation with an additional low-power coil. Fast frequency sweep will supposedly increase the ion current and the average ion charge of ECRIS. The possibility of 100% power modulation is demonstrated using the same control method.
Generic torus canards

NASA Astrophysics Data System (ADS)

Vo, Theodore

2017-10-01

Torus canards are special solutions of fast/slow systems that alternate between attracting and repelling manifolds of limit cycles of the fast subsystem. A relatively new dynamic phenomenon, torus canards have been found in neural applications to mediate the transition from tonic spiking to bursting via amplitude-modulated spiking. In R3, torus canards are degenerate: they require one-parameter families of 2-fast/1-slow systems in order to be observed and even then, they only occur on exponentially thin parameter intervals. The addition of a second slow variable unfolds the torus canard phenomenon, making it generic and robust. That is, torus canards in fast/slow systems with (at least) two slow variables occur on open parameter sets. So far, generic torus canards have only been studied numerically, and their behaviour has been inferred based on averaging and canard theory. This approach, however, has not been rigorously justified since the averaging method breaks down near a fold of periodics, which is exactly where torus canards originate. In this work, we combine techniques from Floquet theory, averaging theory, and geometric singular perturbation theory to show that the average of a torus canard is a folded singularity canard. In so doing, we devise an analytic scheme for the identification and topological classification of torus canards in fast/slow systems with two fast variables and k slow variables, for any positive integer k. We demonstrate the predictive power of our results in a model for intracellular calcium dynamics, where we explain the mechanisms underlying a novel class of elliptic bursting rhythms, called amplitude-modulated bursting, by constructing the torus canard analogues of mixed-mode oscillations. We also make explicit the connection between our results here with prior studies of torus canards and torus canard explosion in R3, and discuss how our methods can be extended to fast/slow systems of arbitrary (finite) dimension.
Comprehensive modulation of tumor progression and regression with periodic fasting and refeeding circles via boosting IGFBP-3 loops and NK responses.

PubMed

Chen, Xiancheng; Lin, Xiaojuan; Li, Meng

2012-10-01

Progressive tumor-bearing patients deserve to benefit from more realistic approaches. Here, a study revealed the impact of modified periodic fasting and refeeding regimen on tumor progression or regression with little or no loss of food intake and body weight. Human A549 lung, HepG-2 liver, and SKOV-3 ovary progressive tumor-bearing mice were established and subjected to 4 wk of periodic fasting/refeeding cycles (PFRC), including periodic 1-d fasting/6-d refeeding weekly (protocol 1) and periodic 2-d fasting/5-d refeeding weekly (P2DF/5DR, protocol 2), with ad libitum (AL)-fed hosts as controls. Afterwards, PFRC groups exhibited tumor growth arrest with some tendency towards regression; especially, complete regression of progressive tumors and metastases comprised between 43.75 and 56.25% of tumor-challenged hosts in P2DF/5DR group (P < 0.05). AL controls, in contrast, showed continuous tumor progression and metastasis. Finally, 100% hosts in P2DF/5DR and 62.5-68.75% in periodic 1-d fasting/6-d refeeding weekly groups survived a 4-month study period vs. only 31.25-37.5% in AL control group. Immunological assays and Luminex microarray revealed that tumor growth remission is mainly via natural killer cell (NK) reactivity and cross-regulation of IGF-binding protein-3, IGF/IGF-receptor, and megakaryocyte growth and development factor autocrine and paracrine loops. In vivo cellular and humoral assays indicated that tumor-regressive induction by PFRC protocols could be partly terminated by NK cell and IGF-binding protein-3 blockade or replenishment of IGF-I/-II and megakaryocyte growth and development factor. These findings offer a better understanding of comprehensive modulation of periodic fasting/refeeding strategy on the balance between tumor progression and regression.
Femtosecond measurements of near-infrared pulse induced mid-infrared transmission modulation of quantum cascade lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, Hong; Liu, Sheng; Center for Advanced Studied in Photonics Research

2014-05-26

We temporally resolved the ultrafast mid-infrared transmission modulation of quantum cascade lasers (QCLs) using a near-infrared pump/mid-infrared probe technique at room temperature. Two different femtosecond wavelength pumps were used with photon energy above and below the quantum well (QW) bandgap. The shorter wavelength pump modulates the mid-infrared probe transmission through interband transition assisted mechanisms, resulting in a high transmission modulation depth and several nanoseconds recovery lifetime. In contrast, pumping with a photon energy below the QW bandgap induces a smaller transmission modulation depth but much faster (several picoseconds) recovery lifetime, attributed to intersubband transition assisted mechanisms. The latter ultrafast modulationmore » (>60 GHz) could provide a potential way to realize fast QCL based free space optical communication.« less
Virtual and flexible digital signal processing system based on software PnP and component works

NASA Astrophysics Data System (ADS)

He, Tao; Wu, Qinghua; Zhong, Fei; Li, Wei

2005-05-01

An idea about software PnP (Plug & Play) is put forward according to the hardware PnP. And base on this idea, a virtual flexible digital signal processing system (FVDSPS) is carried out. FVDSPS is composed of a main control center, many sub-function modules and other hardware I/O modules. Main control center sends out commands to sub-function modules, and manages running orders, parameters and results of sub-functions. The software kernel of FVDSPS is DSP (Digital Signal Processing) module, which communicates with the main control center through some protocols, accept commands or send requirements. The data sharing and exchanging between the main control center and the DSP modules are carried out and managed by the files system of the Windows Operation System through the effective communication. FVDSPS real orients objects, orients engineers and orients engineering problems. With FVDSPS, users can freely plug and play, and fast reconfigure a signal process system according to engineering problems without programming. What you see is what you get. Thus, an engineer can orient engineering problems directly, pay more attention to engineering problems, and promote the flexibility, reliability and veracity of testing system. Because FVDSPS orients TCP/IP protocol, through Internet, testing engineers, technology experts can be connected freely without space. Engineering problems can be resolved fast and effectively. FVDSPS can be used in many fields such as instruments and meter, fault diagnosis, device maintenance and quality control.
Cardiac e-learning: Development of a web-based implantable cardioverter defibrillator educational system.

PubMed

Hickey, Kathleen T; Johnson, Mary P; Biviano, Angelo; Aboelela, Sally; Thomas, Tami; Bakken, Suzanne; Garan, Hasan; Zimmerman, John L; Whang, William

2011-04-01

The objective of this study was to design a Web-based implantable cardioverter defibrillator (ICD) module that would allow greater access to learning which could occur at an individual's convenience outside the fast-paced clinical environment. A Web-based ICD software educational program was developed to provide general knowledge of the function of the ICD and the interpretation of the stored electrocardiograms. This learning tool could be accessed at any time via the Columbia University Internet server, using a unique, password protected login. A series of basic and advanced ICD terms were presented using actual ICD screenshots and videos that simulated scenarios the practitioner would most commonly encounter in the fast-paced clinical setting. To determine the usefulness of the site and improve the module, practitioners were asked to complete a brief (less than 5 min) online survey at the end of the module. Twenty-six practitioners have logged into our Web site: 20 nurses/nurse practitioners, four cardiac fellows, and two other practitioners. The majority of respondents rated the program as easy to use and useful. The success of this module has led to it becoming part of the training for student nurse practitioners before a clinical electrophysiology rotation, and the module is accessed by our cardiac entry level fellows before a rotation in the intensive care unit or electrophysiology service. Remote electronic arrhythmia learning is a successful example of the melding of technology and education to enhance clinical learning.
Frequency-Dependent Modulation of Dopamine Release by Nicotine and Dopamine D1 Receptor Ligands: An In Vitro Fast Cyclic Voltammetry Study in Rat Striatum.

PubMed

Goutier, W; Lowry, J P; McCreary, A C; O'Connor, J J

2016-05-01

Nicotine is a highly addictive drug and exerts this effect partially through the modulation of dopamine release and increasing extracellular dopamine in regions such as the brain reward systems. Nicotine acts in these regions on nicotinic acetylcholine receptors. The effect of nicotine on the frequency dependent modulation of dopamine release is well established and the purpose of this study was to investigate whether dopamine D1 receptor (D1R) ligands have an influence on this. Using fast cyclic voltammetry and rat corticostriatal slices, we show that D1R ligands are able to modulate the effect of nicotine on dopamine release. Nicotine (500 nM) induced a decrease in dopamine efflux at low frequency (single pulse or five pulses at 10 Hz) and an increase at high frequency (100 Hz) electrical field stimulation. The D1R agonist SKF-38393, whilst having no effect on dopamine release on its own or on the effect of nicotine upon multiple pulse evoked dopamine release, did significantly prevent and reverse the effect of nicotine on single pulse dopamine release. Interestingly similar results were obtained with the D1R antagonist SCH-23390. In this study we have demonstrated that the modulation of dopamine release by nicotine can be altered by D1R ligands, but only when evoked by single pulse stimulation, and are likely working via cholinergic interneuron driven dopamine release.
Active modulation of laser coded systems using near infrared video projection system based on digital micromirror device (DMD)

NASA Astrophysics Data System (ADS)

Khalifa, Aly A.; Aly, Hussein A.; El-Sherif, Ashraf F.

2016-02-01

Near infrared (NIR) dynamic scene projection systems are used to perform hardware in-the-loop (HWIL) testing of a unit under test operating in the NIR band. The common and complex requirement of a class of these units is a dynamic scene that is spatio-temporal variant. In this paper we apply and investigate active external modulation of NIR laser in different ranges of temporal frequencies. We use digital micromirror devices (DMDs) integrated as the core of a NIR projection system to generate these dynamic scenes. We deploy the spatial pattern to the DMD controller to simultaneously yield the required amplitude by pulse width modulation (PWM) of the mirror elements as well as the spatio-temporal pattern. Desired modulation and coding of high stable, high power visible (Red laser at 640 nm) and NIR (Diode laser at 976 nm) using the combination of different optical masks based on DMD were achieved. These spatial versatile active coding strategies for both low and high frequencies in the range of kHz for irradiance of different targets were generated by our system and recorded using VIS-NIR fast cameras. The temporally-modulated laser pulse traces were measured using array of fast response photodetectors. Finally using a high resolution spectrometer, we evaluated the NIR dynamic scene projection system response in terms of preserving the wavelength and band spread of the NIR source after projection.
Implementation of a level 1 trigger system using high speed serial (VXS) techniques for the 12GeV high luminosity experimental programs at Thomas Jefferson National Accelerator Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

C. Cuevas, B. Raydo, H. Dong, A. Gupta, F.J. Barbosa, J. Wilson, W.M. Taylor, E. Jastrzembski, D. Abbott

We will demonstrate a hardware and firmware solution for a complete fully pipelined multi-crate trigger system that takes advantage of the elegant high speed VXS serial extensions for VME. This trigger system includes three sections starting with the front end crate trigger processor (CTP), a global Sub-System Processor (SSP) and a Trigger Supervisor that manages the timing, synchronization and front end event readout. Within a front end crate, trigger information is gathered from each 16 Channel, 12 bit Flash ADC module at 4 nS intervals via the VXS backplane, to a Crate Trigger Processor (CTP). Each Crate Trigger Processor receivesmore » these 500 MB/S VXS links from the 16 FADC-250 modules, aligns skewed data inherent of Aurora protocol, and performs real time crate level trigger algorithms. The algorithm results are encoded using a Reed-Solomon technique and transmission of this Level 1 trigger data is sent to the SSP using a multi-fiber link. The multi-fiber link achieves an aggregate trigger data transfer rate to the global trigger at 8 Gb/s. The SSP receives and decodes Reed-Solomon error correcting transmission from each crate, aligns the data, and performs the global level trigger algorithms. The entire trigger system is synchronous and operates at 250 MHz with the Trigger Supervisor managing not only the front end event readout, but also the distribution of the critical timing clocks, synchronization signals, and the global trigger signals to each front end readout crate. These signals are distributed to the front end crates on a separate fiber link and each crate is synchronized using a unique encoding scheme to guarantee that each front end crate is synchronous with a fixed latency, independent of the distance between each crate. The overall trigger signal latency is <3 uS, and the proposed 12GeV experiments at Jefferson Lab require up to 200KHz Level 1 trigger rate.« less
Device and method for imploding a microsphere with a fast liner

DOEpatents

Thode, Lester E.

1981-01-01

A device and method for relativistic electron beam heating of a high-density plasma in a small localized region. A relativistic electron beam generator or accelerator produces a high-voltage electron beam which propagates along a vacuum drift tube and is modulated to initiate electron bunching within the beam. The beam is then directed through a low-density gas chamber which provides isolation between the vacuum modulator and the relativistic electron beam target. The relativistic beam is then applied to a high-density target plasma which typically comprises DT, DD, hydrogen boron or similar thermonuclear gas at a density of 10.sup.17 to 10.sup.20 electrons per cubic centimeter. The target gas is ionized prior to application of the electron beam by means of a laser or other preionization source to form a plasma. Utilizing a relativistic electron beam with an individual particle energy exceeding 3 MeV, classical scattering by relativistic electrons passing through isolation foils is negligible. As a result, relativistic streaming instabilities are initiated within the high-density target plasma causing the relativistic electron beam to efficiently deposit its energy and momentum into a small localized region of the high-density plasma target. Fast liners disposed in the high-density target plasma are explosively or ablatively driven to implosion by a heated annular plasma surrounding the fast liner generated by an annular relativistic electron beam. An azimuthal magnetic field produced by axial current flow in the annular plasma, causes the energy in the heated annular plasma to converge on the fast liner to drive the fast liner to implode a microsphere.
A reconfigurable multicarrier demodulator architecture

NASA Technical Reports Server (NTRS)

Kwatra, S. C.; Jamali, M. M.

1991-01-01

An architecture based on parallel and pipline design approaches has been developed for the Frequency Division Multiple Access/Time Domain Multiplexed (FDMA/TDM) conversion system. The architecture has two main modules namely the transmultiplexer and the demodulator. The transmultiplexer has two pipelined modules. These are the shared multiplexed polyphase filter and the Fast Fourier Transform (FFT). The demodulator consists of carrier, clock, and data recovery modules which are interactive. Progress on the design of the MultiCarrier Demodulator (MCD) using commercially available chips and Application Specific Integrated Circuits (ASIC) and simulation studies using Viewlogic software will be presented at the conference.
pymzML--Python module for high-throughput bioinformatics on mass spectrometry data.

PubMed

Bald, Till; Barth, Johannes; Niehues, Anna; Specht, Michael; Hippler, Michael; Fufezan, Christian

2012-04-01

pymzML is an extension to Python that offers (i) an easy access to mass spectrometry (MS) data that allows the rapid development of tools, (ii) a very fast parser for mzML data, the standard data format in MS and (iii) a set of functions to compare or handle spectra. pymzML requires Python2.6.5+ and is fully compatible with Python3. The module is freely available on http://pymzml.github.com or pypi, is published under LGPL license and requires no additional modules to be installed. christian@fufezan.net.

Development of spectral analysis math models and software program and spectral analyzer, digital converter interface equipment design

NASA Technical Reports Server (NTRS)

Hayden, W. L.; Robinson, L. H.

1972-01-01

Spectral analyses of angle-modulated communication systems is studied by: (1) performing a literature survey of candidate power spectrum computational techniques, determining the computational requirements, and formulating a mathematical model satisfying these requirements; (2) implementing the model on UNIVAC 1230 digital computer as the Spectral Analysis Program (SAP); and (3) developing the hardware specifications for a data acquisition system which will acquire an input modulating signal for SAP. The SAP computational technique uses extended fast Fourier transform and represents a generalized approach for simple and complex modulating signals.
Low-inductance switch and capacitor energy storage modules made of packages of industrial condensers IK50-3

NASA Astrophysics Data System (ADS)

Bykov, Yu A.; Krastelev, E. G.; Sedin, A. A.; Feduschak, V. F.

2017-05-01

A low-inductance module of a high-current capacitive energy storage with an operating voltage of 40 kV is developed. The design of the module is based on the application of capacitive sections of the industrial condenser IK50-3. The module includes two capacitors of 0.35 μF each, one common low-jitter triggered gas switch and 2 groups of output cables of 4 from each capacitor. A bus bars topology developed for the switch and cables connections provides a small total inductance of the discharge circuit, for the module with the output cables KVIM of 0.5 m long, it is lower than 40 nH. The set of 10 modules is now used for driving the 20 stages linear transformer for a fast charging of the pulse forming line of the high-current nanosecond accelerator. A design of the module and the results of tests of a single module and a set of 10 are presented.
The phase 1 upgrade of the CMS Pixel Front-End Driver

NASA Astrophysics Data System (ADS)

Friedl, M.; Pernicka, M.; Steininger, H.

2010-12-01

The pixel detector of the CMS experiment at the LHC is read out by analog optical links, sending the data to 9U VME Front-End Driver (FED) boards located in the electronics cavern. There are plans for the phase 1 upgrade of the pixel detector (2016) to add one more layer, while significantly cutting down the overall material budget. At the same time, the optical data transmission will be replaced by a serialized digital scheme. A plug-in board solution with a high-speed digital optical receiver has been developed for the Pixel-FED readout boards and will be presented along with first tests of the future optical link.
TRAMP; The next generation data acquisition for RTP

DOE Office of Scientific and Technical Information (OSTI.GOV)

van Haren, P.C.; Wijnoltz, F.

1992-04-01

The Rijnhuizen Tokamak Project RTP is a medium-sized tokamak experiment, which requires a very reliable data-acquisition system, due to its pulsed nature. Analyzing the limitations of an existing CAMAC-based data-acquisition system showed, that substantial increase of performance and flexibility could best be obtained by the construction of an entirely new system. This paper discusses this system, CALLED TRAMP (Transient Recorder and Amoeba Multi Processor), based on tailor-made transient recorders with a multiprocessor computer system in VME running Amoeba. The performance of TRAMP exceeds the performance of the CAMAC system by a factor of four. The plans to increase the flexibilitymore » and for a further increase of performance are presented.« less
Research on virtual network load balancing based on OpenFlow

NASA Astrophysics Data System (ADS)

Peng, Rong; Ding, Lei

2017-08-01

The Network based on OpenFlow technology separate the control module and data forwarding module. Global deployment of load balancing strategy through network view of control plane is fast and of high efficiency. This paper proposes a Weighted Round-Robin Scheduling algorithm for virtual network and a load balancing plan for server load based on OpenFlow. Load of service nodes and load balancing tasks distribution algorithm will be taken into account.
Rapid Mars transits with exhaust-modulated plasma propulsion

NASA Technical Reports Server (NTRS)

Chang-Diaz, Franklin R.; Braden, Ellen; Johnson, Ivan; Hsu, Michael M.; Yang, Tien Fang

1995-01-01

The operational characteristics of the Exhaust-Modulated Plasma Rocket are described. Four basic human and robotic mission scenarios to Mars are analyzed using numerical optimization techniques at variable specific impulse and constant power. The device is well suited for 'split-sprint' missions, allowing fast, one-way low-payload human transits of 90 to 104 days, as well as slower, 180-day, high-payload robotic precursor flights. Abort capabilities, essential for human missions, are also explored.
Using a fast dual-wavelength imaging ellipsometric system to measure the flow thickness profile of an oil thin film

NASA Astrophysics Data System (ADS)

Kuo, Chih-Wei; Han, Chien-Yuan; Jhou, Jhe-Yi; Peng, Zeng-Yi

2017-11-01

Dual-wavelength light sources with stroboscopic illumination technique were applied in a process of photoelastic modulated ellipsometry to retrieve two-dimensional ellipsometric parameters of thin films on a silicon substrate. Two laser diodes were alternately switched on and modulated by a programmable pulse generator to generate four short pulses at specific temporal phase angles in a modulation cycle, and short pulses were used to freeze the intensity variation of the PEM modulated signal that allows ellipsometric images to be captured by a charge-coupled device. Although the phase retardation of a photoelastic modulator is related to the light wavelength, we employed an equivalent phase retardation technique to avoid any setting from the photoelastic modulator. As a result, the ellipsometric parameters of different wavelengths may be rapidly obtained using this dual-wavelength ellipsometric system every 4 s. Both static and dynamic experiments are demonstrated in this work.
Cerenkov emissions of ion acoustic-like waves generated by electron beams emitted during TSS 1R

NASA Astrophysics Data System (ADS)

Huang, C. Y.; Burke, W. J.; Hardy, D. A.; Gough, M. P.; Olson, D. G.; Gentile, L. C.; Gilchrist, B. E.; Bonifazi, C.; Raitt, W. J.; Thompson, D. C.

During the Tethered Satellite System reflight the Spacecraft Particle Correlation Experiment detected fluxes of energetic electrons and ions that were simultaneously modulated at low frequencies during firings of both the fast pulsed electron gun (FPEG) and the electron generator assembly (EGA). The modulations have been interpreted as signatures of large-amplitude, ion acoustic-like waves excited in Cerenkov interactions between electron beams and ambient plasmas as the shuttle moved at supersonic speeds across the ionospheric magnetic field. We present examples of particle modulations observed during steady beam emissions. Measurements show that (1) most electron modulations were at frequencies of several hundred Hertz and (2) ions modulated at similar frequencies appeared at spectral energy peaks during shuttle negative charging events. Detection of modulated ion fluxes confirms the Cerenkov emission hypothesis. Observed frequency variations indicate that the EGA beam underwent more spatial spreading than the FPEG beam.
Research on channel characteristics of differential multi pulse position modulation without background noise

NASA Astrophysics Data System (ADS)

Gao, Zhuo; Zhan, Weida; Sun, Quan; Hao, Ziqiang

2018-04-01

Differential multi-pulse position modulation (DMPPM) is a new type of modulation technology. There is a fast transmission rate, high bandwidth utilization, high modulation rate characteristics. The study of DMPPM modulation has important scientific value and practical significance. Channel capacity is one of the important indexes to measure the communication capability of communication system, and studying the channel capacity of DMPPM without background noise is the key to analyze the characteristics of DMPPM. The DMPPM theoretical model is established. The symbol structure of DMPPM with guard time slot is analyzed, and the channel capacity expression of DMPPM is deduced. Simulation analysis by MATLAB. The curves of unit channel capacity and capacity efficiency at different pulse and photon counting rates are analyzed. The results show that DMPPM is more advantageous than multi-pulse position modulation (MPPM), and is more suitable for future wireless optical communication system.
Clonazepam increases in vivo striatal extracellular glucose in diabetic rats after glucose overload.

PubMed

Gomez, Rosane; Barros, Helena M T

2003-12-01

Hyperglycemia modulates brain function, including neuronal excitability, neurotransmitter release and behavioral changes. There may be connections between the GABAergic system, glucose sensing neurons and glucose in the neuronal environment that shed light on the mechanism by which GABA(A) agents influence depressive behavior in diabetic rats submitted to the forced swimming test. We aimed to investigate whether clonazepam (CNZ), a GABA(A) receptor positive modulator, modifies in vivo striatal extracellular glucose levels in diabetic rats under fasting condition or after oral glucose overload. Streptozotocin diabetic and nondiabetic rats were submitted to in vivo striatal microdialysis. Perfusate samples were collected at baseline, during fasting and following administration of CNZ (0.25 mg/kg) and oral glucose overload. Blood glucose and striatal extracellular glucose were measured simultaneously at several time points. Fasting striatal glucose levels were higher in diabetic than in nondiabetic rats and the differences between these animals were maintained after glucose overload. The increases in extracellular striatal glucose after glucose overload were around 40% and blood to brain transference was decreased in diabetics. CNZ treatment paradoxically increased striatal glucose after glucose overload in diabetic rats, which may mark the dysfunction in brain glucose homeostasis.
A Fast Hartley Transform based novel optical OFDM system for VLC indoor application with constant envelope PAPR reduction technique using frequency modulation

NASA Astrophysics Data System (ADS)

Singh, Vinay Kumar; Dalal, U. D.

2017-10-01

In this research literature we present a unique optical OFDM system for Visible Light Communication (VLC) intended for indoor application which uses a non conventional transform-Fast Hartley Transform and an effective method to reduce the peak to average power ratio (PAPR) of the OFDM signal based on frequency modulation leading to a constant envelope (CE) signal. The proposed system is analyzed by a complete mathematical model and verified by the concurrent simulations results. The use of the non conventional transform makes the system computationally more desirable as it does not require the Hermitian symmetry constraint to yield real signals. The frequency modulation of the baseband signal converge random peaks into a CE signal. This leads to alleviation of the non linearity effects of the LED used in the link for electrical to optical conversion. The PAPR is reduced to 2 dB by this technique in this work. The impact of the modulation index on the performance of the system is also investigated. An optimum modulation depth of 30% gives better results. The additional phase discontinuity incurring on the demodulated signal at the receiver is also significantly reduced. A comparison of the improvement in phase discontinuity of the proposed technique of combating the PAPR with the previously known phase modulation technique is also presented in this work. Based on the channel metrics we evaluate the system performance and report an improvement of 1.2 dB at the FEC threshold. The proposed system is simple in design and computationally efficient and this can be incorporated into the present VLC system without much alteration thereby making it a cost effective solution.
Real-time terahertz imaging through self-mixing in a quantum-cascade laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wienold, M., E-mail: martin.wienold@dlr.de; Rothbart, N.; Hübers, H.-W.

2016-07-04

We report on a fast self-mixing approach for real-time, coherent terahertz imaging based on a quantum-cascade laser and a scanning mirror. Due to a fast deflection of the terahertz beam, images with frame rates up to several Hz are obtained, eventually limited by the mechanical inertia of the employed scanning mirror. A phase modulation technique allows for the separation of the amplitude and phase information without the necessity of parameter fitting routines. We further demonstrate the potential for transmission imaging.
High-resolution, high-sensitivity, ground-based solar spectropolarimetry with a new fast imaging polarimeter. I. Prototype characterization

NASA Astrophysics Data System (ADS)

Iglesias, F. A.; Feller, A.; Nagaraju, K.; Solanki, S. K.

2016-05-01

Context. Remote sensing of weak and small-scale solar magnetic fields is of utmost relevance when attempting to respond to a number of important open questions in solar physics. This requires the acquisition of spectropolarimetric data with high spatial resolution (~10-1 arcsec) and low noise (10-3 to 10-5 of the continuum intensity). The main limitations to obtain these measurements from the ground, are the degradation of the image resolution produced by atmospheric seeing and the seeing-induced crosstalk (SIC). Aims: We introduce the prototype of the Fast Solar Polarimeter (FSP), a new ground-based, high-cadence polarimeter that tackles the above-mentioned limitations by producing data that are optimally suited for the application of post-facto image restoration, and by operating at a modulation frequency of 100 Hz to reduce SIC. Methods: We describe the instrument in depth, including the fast pnCCD camera employed, the achromatic modulator package, the main calibration steps, the effects of the modulation frequency on the levels of seeing-induced spurious signals, and the effect of the camera properties on the image restoration quality. Results: The pnCCD camera reaches 400 fps while keeping a high duty cycle (98.6%) and very low noise (4.94 e- rms). The modulator is optimized to have high (>80%) total polarimetric efficiency in the visible spectral range. This allows FSP to acquire 100 photon-noise-limited, full-Stokes measurements per second. We found that the seeing induced signals that are present in narrow-band, non-modulated, quiet-sun measurements are (a) lower than the noise (7 × 10-5) after integrating 7.66 min, (b) lower than the noise (2.3 × 10-4) after integrating 1.16 min and (c) slightly above the noise (4 × 10-3) after restoring case (b) by means of a multi-object multi-frame blind deconvolution. In addition, we demonstrate that by using only narrow-band images (with low S/N of 13.9) of an active region, we can obtain one complete set of high-quality restored measurements about every 2 s.
Electro-optic modulation for high-speed characterization of entangled photon pairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lukens, Joseph M.; Odele, Ogaga D.; Leaird, Daniel E.

In this study, we demonstrate a new biphoton manipulation and characterization technique based on electro-optic intensity modulation and time shifting. By applying fast modulation signals with a sharply peaked cross-correlation to each photon from an entangled pair, it is possible to measure temporal correlations with significantly higher precision than that attainable using standard single-photon detection. Low-duty-cycle pulses and maximal-length sequences are considered as modulation functions, reducing the time spread in our correlation measurement by a factor of five compared to our detector jitter. With state-of-the-art electro-optic components, we expect the potential to surpass the speed of any single-photon detectors currentlymore » available.« less
Versatile module for experiments with focussing neutron guides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, T.; Pfleiderer, C.; Böni, P.

2014-09-22

We report the development of a versatile module that permits fast and reliable use of focussing neutron guides under varying scattering angles. A simple procedure for setting up the module and neutron guides is illustrated by typical intensity patterns to highlight operational aspects as well as typical parasitic artefacts. Combining a high-precision alignment table with separate housings for the neutron guides on kinematic mounts, the change-over between neutron guides with different focussing characteristics requires no readjustments of the experimental setup. Exploiting substantial gain factors, we demonstrate the performance of this versatile neutron scattering module in a study of the effectsmore » of uniaxial stress on the domain populations in the transverse spin density wave phase of single crystal Cr.« less
Electro-optic modulation for high-speed characterization of entangled photon pairs

DOE PAGES

Lukens, Joseph M.; Odele, Ogaga D.; Leaird, Daniel E.; ...

2015-11-10

In this study, we demonstrate a new biphoton manipulation and characterization technique based on electro-optic intensity modulation and time shifting. By applying fast modulation signals with a sharply peaked cross-correlation to each photon from an entangled pair, it is possible to measure temporal correlations with significantly higher precision than that attainable using standard single-photon detection. Low-duty-cycle pulses and maximal-length sequences are considered as modulation functions, reducing the time spread in our correlation measurement by a factor of five compared to our detector jitter. With state-of-the-art electro-optic components, we expect the potential to surpass the speed of any single-photon detectors currentlymore » available.« less
Fast Wave Transmission Measurements on Alcator C-Mod

NASA Astrophysics Data System (ADS)

Reardon, J.; Bonoli, P. T.; Porkolab, M.; Takase, Y.; Wukitch, S. J.

1997-11-01

Data are presented from an array of single-turn loop probes newly installed on the inner wall of C-Mod, directly opposite one of the two fast-wave antennas. The 8-loop array extends 32^circ in the toroidal direction at the midplane and can distinguish electromagnetic from electrostatic modes. Data are acquired by 1GHz digitizer, spectrum analyzer, and RF detector circuit. Phase measurements during different heating scenarios show evidence of both standing and travelling waves. The measurement of toroidal mode number N_tor (conserved under the assumption of axisymmetry) is used to guide the toroidal full-wave code TORIC(Brambilla, M., IPP Report 5/66, February 1996). Amplitude measurements show modulation both by Type III ELMs and sawteeth; the observed sawtooth modulation may be interpreted as due to changes in central absorption. The amplitude of tildeB_tor measured at the inner wall is compared to the prediction of TORIC.
A system for the automated data-acquisition of fast transient signals in excitable membranes.

PubMed

Bustamante, J O

1988-01-01

This paper provides a description of a system for the acquisition of fast transient currents flowing across excitable membranes. The front end of the system consists of a CAMAC crate with plug-in modules. The modules provide control of CAMAC operations, analog to digital conversion, electronic memory storage and timing of events. The signals are transferred under direct memory access to an IBM PC microcomputer through a special-purpose interface. Voltage levels from a digital to analog board in the microcomputer are passed through multiplexers to produce the desired voltage pulse patterns to elicit the transmembrane currents. The dead time between consecutive excitatory voltage pulses is limited only by the computer data bus and the software characteristics. The dead time between data transfers can be reduced to the order of milliseconds, which is sufficient for most experiments with transmembrane ionic currents.
Rapid comprehensive characterization of crude oils by thermogravimetry coupled to fast modulated gas chromatography-single photon ionization time-of-flight mass spectrometry.

PubMed

Wohlfahrt, S; Fischer, M; Saraji-Bozorgzad, M; Matuschek, G; Streibel, T; Post, E; Denner, T; Zimmermann, R

2013-09-01

Comprehensive multi-dimensional hyphenation of a thermogravimetry device (i.e. a thermobalance) to gas chromatography and single photon ionization-time-of-flight mass spectrometry (TG-GC×SPI-MS) has been used to investigate two crude oil samples of different geographical origin. The source of the applied vacuum ultraviolet radiation is an electron beam pumped rare gas excimer lamp (EBEL). The soft photoionization favors the formation of molecular ions. Introduction of a fast, rapidly modulated gas chromatographic separation step in comparison with solely TG-SPI-MS enables strongly enhanced detection especially with such highly complex organic matrices as crude oil. In contrast with former TG-SPI-MS measurements, separation and identification of overlying substances is possible because of different GC retention times. The specific contribution of isobaric compounds to one mass signal is determined for alkanes, naphthalenes, alkylated benzenes, and other compounds.
(Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents.

PubMed

Lee, Hyosung; Park, Ki Duk; Yang, Xiao-Fang; Dustrude, Erik T; Wilson, Sarah M; Khanna, Rajesh; Kohn, Harold

2013-07-25

We have reported that compounds containing a biaryl linked unit (Ar-X-Ar') modulated Na(+) currents by promoting slow inactivation and fast inactivation processes and by inducing frequency (use)-dependent inhibition of Na(+) currents. These electrophysiological properties have been associated with the mode of action of several antiepileptic drugs. In this study, we demonstrate that the readily accessible (biphenyl-4-yl)methylammonium chlorides (compound class B) exhibited a broad range of anticonvulsant activities in animal models, and in the maximal electroshock seizure test the activity of (3'-trifluoromethoxybiphenyl-4-yl)methylammonium chloride (8) exceeded that of phenobarbital and phenytoin upon oral administration to rats. Electrophysiological studies of 8 using mouse catecholamine A-differentiated cells and rat embryonic cortical neurons confirmed that 8 promoted slow and fast inactivation in both cell types but did not affect the frequency (use)-dependent block of Na(+) currents.

The time-dependence of exchange-induced relaxation during modulated radio frequency pulses.

PubMed

Sorce, Dennis J; Michaeli, Shalom; Garwood, Michael

2006-03-01

The problem of the relaxation of identical spins 1/2 induced by chemical exchange between spins with different chemical shifts in the presence of time-dependent RF irradiation (in the first rotating frame) is considered for the fast exchange regime. The solution for the time evolution under the chemical exchange Hamiltonian in the tilted doubly rotating frame (TDRF) is presented. Detailed derivation is specified to the case of a two-site chemical exchange system with complete randomization between jumps of the exchanging spins. The derived theory can be applied to describe the modulation of the chemical exchange relaxation rate constants when using a train of adiabatic pulses, such as the hyperbolic secant pulse. Theory presented is valid for quantification of the exchange-induced time-dependent rotating frame longitudinal T1rho,ex and transverse T2rho,ex relaxations in the fast chemical exchange regime.
Redox modulation of A-type K+ currents in pain-sensing dorsal root ganglion neurons.

PubMed

Hsieh, Chi-Pan

2008-06-06

Redox modulation of fast inactivation has been described in certain cloned A-type voltage-gated K(+) (Kv) channels in expressing systems, but the effects remain to be demonstrated in native neurons. In this study, we examined the effects of cysteine-specific redox agents on the A-type K(+) currents in acutely dissociated small diameter dorsal root ganglion (DRG) neurons from rats. The fast inactivation of most A-type currents was markedly removed or slowed by the oxidizing agents 2,2'-dithio-bis(5-nitropyridine) (DTBNP) and chloramine-T. Dithiothreitol, a reducing agent for the disulfide bond, restored the inactivation. These results demonstrated that native A-type K(+) channels, probably Kv1.4, could switch the roles between inactivating and non-inactivating K(+) channels via redox regulation in pain-sensing DRG neurons. The A-type channels may play a role in adjusting pain sensitivity in response to peripheral redox conditions.
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

PubMed

Vaxillaire, Martine; Cavalcanti-Proença, Christine; Dechaume, Aurélie; Tichet, Jean; Marre, Michel; Balkau, Beverley; Froguel, Philippe

2008-08-01

Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate. Genome-wide association studies for type 2 diabetes identified GCKR as a potential locus for modulating triglyceride levels. We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk. Genotype effects of rs1260326 were studied in 4,833 participants from the prospective DESIR (Data from an Epidemiological Study on the Insulin Resistance syndrome) cohort both at inclusion and using the measurements at follow-up. The minor T-allele of rs1260326 was strongly associated with lower fasting glucose (-1.43% per T-allele; P = 8 x 10(-13)) and fasting insulin levels (-4.23%; P = 3 x 10(-7)), lower homeostasis model assessment of insulin resistance index (-5.69%; P = 1 x 10(-8)), and, conversely, higher triglyceride levels (3.41%; P = 1 x 10(-4)) during the 9-year study. These effects relate to a lower risk of hyperglycemia (odds ratio [OR] 0.79 [95% CI 0.70-0.88]; P = 4 x 10(-5)) and of incident cases during the study (hazard ratio [HR] 0.83 [0.74-0.95]; P = 0.005). Moreover, an additive effect of GCKR rs1260326(T) and GCK (-30G) alleles conferred lower fasting glycemia (P = 1 x 10(-13)), insulinemia (P = 5 x 10(-6)), and hyperglycemia risk (P = 1 x 10(-6)). GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated.
Losses analysis of soft magnetic ring core under sinusoidal pulse width modulation (SPWM) and space vector pulse width modulation (SVPWM) excitations

NASA Astrophysics Data System (ADS)

Gao, Hezhe; Li, Yongjian; Wang, Shanming; Zhu, Jianguo; Yang, Qingxin; Zhang, Changgeng; Li, Jingsong

2018-05-01

Practical core losses in electrical machines differ significantly from those experimental results using the standardized measurement method, i.e. Epstein Frame method. In order to obtain a better approximation of the losses in an electrical machine, a simulation method considering sinusoidal pulse width modulation (SPWM) and space vector pulse width modulation (SVPWM) waveforms is proposed. The influence of the pulse width modulation (PWM) parameters on the harmonic components in SPWM and SVPWM is discussed by fast Fourier transform (FFT). Three-level SPWM and SVPWM are analyzed and compared both by simulation and experiment. The core losses of several ring samples magnetized by SPWM, SVPWM and sinusoidal alternating current (AC) are obtained. In addition, the temperature rise of the samples under SPWM, sinusoidal excitation are analyzed and compared.
A new linear structured light module based on the MEMS micromirror

NASA Astrophysics Data System (ADS)

Zhou, Peng; Shen, Wenjiang; Yu, Huijun

2017-10-01

A new linear structured light module based on the Micro-Electro-Mechanical System (MEMS) two-dimensional scanning micromirror was designed and created. This module consists of a laser diode, a convex lens, and the MEMS micromirror. The laser diode generates the light and the convex lens control the laser beam to converge on a single point with large depth of focus. The fast scan in horizontal direction of the micromirror will turn the laser spot into a homogenous laser line. Meanwhile, the slow scan in vertical direction of the micromirror will move the laser line in the vertical direction. The width of the line generated by this module is 300μm and the length is 120mm and the moving distance is 100mm at 30cm away from the module. It will promote the development of industrial detection.
A scheme for recording a fast process at nanosecond scale by using digital holographic interferometry with continuous wave laser

NASA Astrophysics Data System (ADS)

Wang, Jun; Zhao, Jianlin; Di, Jianglei; Jiang, Biqiang

2015-04-01

A scheme for recording fast process at nanosecond scale by using digital holographic interferometry with continuous wave (CW) laser is described and demonstrated experimentally, which employs delayed-time fibers and angular multiplexing technique and can realize the variable temporal resolution at nanosecond scale and different measured depths of object field at certain temporal resolution. The actual delay-time is controlled by two delayed-time fibers with different lengths. The object field information in two different states can be simultaneously recorded in a composite hologram. This scheme is also suitable for recording fast process at picosecond scale, by using an electro-optic modulator.
Anxiety and Depression: Mouse Genetics and Pharmacological Approaches to the Role of GABAA Receptor Subtypes

PubMed Central

Smith, Kiersten S.; Rudolph, Uwe

2012-01-01

GABAA receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABAA receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABAA receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABAA receptor subtypes involved in physiological and pharmacological modulation of emotions. PMID:21810433
Wide-field imaging through scattering media by scattered light fluorescence microscopy

NASA Astrophysics Data System (ADS)

Zhou, Yulan; Li, Xun

2017-08-01

To obtain images through scattering media, scattered light fluorescence (SLF) microscopy that utilizes the optical memory effect has been developed. However, the small field of view (FOV) of SLF microscopy limits its application. In this paper, we have introduced a re-modulation method to achieve wide-field imaging through scattering media by SLF microscopy. In the re-modulation method, to raster scan the focus across the object plane, the incident wavefront is re-modulated via a spatial light modulator (SLM) in the updated phase compensation calculated using the optimized iterative algorithm. Compared with the conventional optical memory effect method, the re-modulation method can greatly increase the FOV of a SLF microscope. With the phase compensation theoretically calculated, the process of updating the phase compensation of a high speed SLM is fast. The re-modulation method does not increase the imaging time. The re-modulation method is, therefore, expected to make SLF microscopy have much wider applications in biology, medicine and physiology.
Application of SNMP on CATV

NASA Astrophysics Data System (ADS)

Huang, Hong-bin; Liu, Wei-ping; Chen, Shun-er; Zheng, Liming

2005-02-01

A new type of CATV network management system developed by universal MCU, which supports SNMP, is proposed in this paper. From the point of view in both hardware and software, the function and method of every modules inside the system, which include communications in the physical layer, protocol process, data process, and etc, are analyzed. In our design, the management system takes IP MAN as data transmission channel and every controlled object in the management structure has a SNMP agent. In the SNMP agent developed, there are four function modules, including physical layer communication module, protocol process module, internal data process module and MIB management module. In the paper, the structure and function of every module are designed and demonstrated while the related hardware circuit, software flow as well as the experimental results are tested. Furthermore, by introducing RTOS into the software programming, the universal MCU procedure can conducts such multi-thread management as fast Ethernet controller driving, TCP/IP process, serial port signal monitoring and so on, which greatly improves efficiency of CPU.
Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

PubMed Central

Kernbauer, Elisabeth; Hölzl, Markus A.; Hofer, Johannes; Gualdoni, Guido A.; Schmetterer, Klaus G.; Miftari, Fitore; Sobanov, Yury; Meshcheryakova, Anastasia; Mechtcheriakova, Diana; Witzeneder, Nadine; Greiner, Georg; Ohradanova-Repic, Anna; Waidhofer-Söllner, Petra; Säemann, Marcus D.; Decker, Thomas

2017-01-01

A crucial role of cell metabolism in immune cell differentiation and function has been recently established. Growing evidence indicates that metabolic processes impact both, innate and adaptive immunity. Since a down-stream integrator of metabolic alterations, mammalian target of rapamycin (mTOR), is responsible for controlling the balance between pro-inflammatory interleukin (IL)-12 and anti-inflammatory IL-10, we investigated the effect of upstream interference using metabolic modulators on the production of pro- and anti-inflammatory cytokines. Cytokine release and protein expression in human and murine myeloid cells was assessed after toll-like receptor (TLR)-activation and glucose-deprivation or co-treatment with 5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK) activators. Additionally, the impact of metabolic interference was analysed in an in-vivo mouse model. Glucose-deprivation by 2-deoxy-D-glucose (2-DG) increased the production of IL-12p40 and IL-23p19 in monocytes, but dose-dependently inhibited the release of anti-inflammatory IL-10. Similar effects have been observed using pharmacological AMPK activation. Consistently, an inhibition of the tuberous sclerosis complex-mTOR pathway was observed. In line with our in vitro observations, glycolysis inhibition with 2-DG showed significantly reduced bacterial burden in a Th2-prone Listeria monocytogenes mouse infection model. In conclusion, we showed that fasting metabolism modulates the IL-12/IL-10 cytokine balance, establishing novel targets for metabolism-based immune-modulation. PMID:28742108
New Method to Calculate the Time Variation of the Force Field Parameter

NASA Astrophysics Data System (ADS)

Santiago, A.; Lara, A.; Enríquez-Rivera, O.; Caballero-Lopez, R. A.

2018-03-01

Galactic cosmic rays (CRs) entering the heliosphere are affected by interplanetary magnetic fields and solar wind disturbances resulting in the modulation of the CR total flux observed in the inner heliosphere. The so-called force field model is often used to compute the galactic CR spectrum modulated by the solar activity due to the fact that it characterizes this process by only one parameter (the modulation potential, ϕ). In this work, we present two types of an empirical simplification (ES) method used to reconstruct the time variation of the modulation potential (Δϕ). Our ES offers a simple and fast alternative to compute the Δϕ at any desired time. The first ES type is based on the empirical fact that the dependence between Δϕ and neutron monitor (NM) count rates can be parameterized by a second-degree polynomial. The second ES type is based on the assumption that there is a inverse relation between Δϕ and NM count rates. We report the parameters found for the two types, which may be used to compute Δϕ for some NMs in a very fast and efficient way. In order to test the validity of the proposed ES, we compare our results with Δϕ obtained from literature. Finally, we apply our method to obtain the proton and helium spectra of primary CRs near the Earth at four randomly selected times.
KSC-2014-2856

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, a Lockheed Martin technician monitors the progress as a crane is used to lift the Orion service module from a test stand and move it to the Final Assembly and System Testing, or FAST, cell further down the aisle. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, prior to rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2858

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin engineers and technicians monitor the progress as a crane is used to move the Orion service module to the Final Assembly and System Testing, or FAST, cell further down the aisle. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2859

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin engineers and technicians monitor the progress as a crane is used to move the Orion service module to the Final Assembly and System Testing, or FAST, cell further down the aisle. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
KSC-2014-2857

NASA Image and Video Library

2014-06-06

CAPE CANAVERAL, Fla. -- Inside the Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA and Lockheed Martin technicians and engineers monitor the progress as a crane is used to lift the Orion service module from a test stand and move it to the Final Assembly and System Testing, or FAST, cell further down the aisle. The Orion crew module will be stacked on the service module in the FAST cell and then both modules will be put through their final system tests for Exploration Flight Test-1, or EFT-1, before rolling out of the facility for integration with the United Launch Alliance Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch later this year atop a Delta IV rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Glenn Benson
Gastrointestinal and renal responses to variable water intake in whitebellied sunbirds and New Holland honeyeaters.

PubMed

Purchase, Cromwell; Napier, Kathryn R; Nicolson, Susan W; McWhorter, Todd J; Fleming, Patricia A

2013-05-01

Nectarivores face a constant challenge in terms of water balance, experiencing water loading or dehydration when switching between food plants or between feeding and fasting. To understand how whitebellied sunbirds and New Holland honeyeaters meet the challenges of varying preformed water load, we used the elimination of intramuscular-injected [(14)C]-l-glucose and (3)H2O to quantify intestinal and renal water handling on diets varying in sugar concentration. Both sunbirds and honeyeaters showed significant modulation of intestinal water absorption, allowing excess water to be shunted through the intestine when on dilute diets. Despite reducing their fractional water absorption, both species showed linear increases in water flux and fractional body water turnover as water intake increased (both afternoon and morning), suggesting that the modulation of fractional water absorption was not sufficient to completely offset dietary water loads. In both species, glomerular filtration rate was independent of water gain (but was higher for the afternoon), as was renal fractional water reabsorption (measured in the afternoon). During the natural overnight fast, both sunbirds and honeyeaters arrested whole kidney function. Evaporative water loss in sunbirds was variable but correlated with water gain. Both sunbirds and honeyeaters appear to modulate intestinal water absorption as an important component of water regulation to help deal with massive preformed water loads. Shutting down glomerular filtration rate during the overnight fast is another way of saving energy for osmoregulatory function. Birds maintain osmotic balance on diets varying markedly in preformed water load by varying both intestinal water absorption and excretion through the intestine and kidneys.
Modulation of electroencephalograph activity by manual acupuncture stimulation in healthy subjects: An autoregressive spectral analysis

NASA Astrophysics Data System (ADS)

Yi, Guo-Sheng; Wang, Jiang; Deng, Bin; Wei, Xi-Le; Han, Chun-Xiao

2013-02-01

To investigate whether and how manual acupuncture (MA) modulates brain activities, we design an experiment where acupuncture at acupoint ST36 of the right leg is used to obtain electroencephalograph (EEG) signals in healthy subjects. We adopt the autoregressive (AR) Burg method to estimate the power spectrum of EEG signals and analyze the relative powers in delta (0 Hz-4 Hz), theta (4 Hz-8 Hz), alpha (8 Hz-13 Hz), and beta (13 Hz-30 Hz) bands. Our results show that MA at ST36 can significantly increase the EEG slow wave relative power (delta band) and reduce the fast wave relative powers (alpha and beta bands), while there are no statistical differences in theta band relative power between different acupuncture states. In order to quantify the ratio of slow to fast wave EEG activity, we compute the power ratio index. It is found that the MA can significantly increase the power ratio index, especially in frontal and central lobes. All the results highlight the modulation of brain activities with MA and may provide potential help for the clinical use of acupuncture. The proposed quantitative method of acupuncture signals may be further used to make MA more standardized.
Low voltage polymer network liquid crystal for infrared spatial light modulators.

PubMed

Peng, Fenglin; Xu, Daming; Chen, Haiwei; Wu, Shin-Tson

2015-02-09

We report a low-voltage and fast-response polymer network liquid crystal (PNLC) infrared phase modulator. To optimize device performance, we propose a physical model to understand the curing temperature effect on average domain size. Good agreement between model and experiment is obtained. By optimizing the UV curing temperature and employing a large dielectric anisotropy LC host, we have lowered the 2π phase change voltage to 22.8V at 1.55μm wavelength while keeping response time at about 1 ms. Widespread application of such a PNLC integrated into a high resolution liquid-crystal-on-silicon (LCoS) for infrared spatial light modulator is foreseeable.
Alkali vapor pressure modulation on the 100 ms scale in a single-cell vacuum system for cold atom experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dugrain, Vincent; Reichel, Jakob; Rosenbusch, Peter

2014-08-15

We describe and characterize a device for alkali vapor pressure modulation on the 100 ms timescale in a single-cell cold atom experiment. Its mechanism is based on optimized heat conduction between a current-modulated alkali dispenser and a heat sink at room temperature. We have studied both the short-term behavior during individual pulses and the long-term pressure evolution in the cell. The device combines fast trap loading and relatively long trap lifetime, enabling high repetition rates in a very simple setup. These features make it particularly suitable for portable atomic sensors.
Photorefractive detection of tagged photons in ultrasound modulated optical tomography of thick biological tissues.

PubMed

Ramaz, F; Forget, B; Atlan, M; Boccara, A C; Gross, M; Delaye, P; Roosen, G

2004-11-01

We present a new and simple method to obtain ultrasound modulated optical tomography images in thick biological tissues with the use of a photorefractive crystal. The technique offers the advantage of spatially adapting the output speckle wavefront by analysing the signal diffracted by the interference pattern between this output field and a reference beam, recorded inside the photorefractive crystal. Averaging out due to random phases of the speckle grains vanishes, and we can use a fast single photodetector to measure the ultrasound modulated optical contrast. This technique offers a promising way to make direct measurements within the decorrelation time scale of living tissues.

Ivy and neurogliaform interneurons are a major target of μ opioid receptor modulation

PubMed Central

Krook-Magnuson, Esther; Luu, Lillian; Lee, Sang-Hun; Varga, Csaba; Soltesz, Ivan

2011-01-01

Mu opioid receptors (μORs) are selectively expressed on interneurons in area CA1 of the hippocampus. Fast-spiking, parvalbumin expressing, basket cells express μORs, but circumstantial evidence suggests that another major, unidentified, GABAergic cell class must also be modulated by μORs. Here we report that the abundant, dendritically targeting, neurogliaform family of cells (Ivy and neurogliaform cells) is a previously unrecognized target of direct modulation by μORs. Ivy and neurogliaform cells are not only numerous, but also have unique properties, including promiscuous gap junctions formed with various interneuronal subtypes, volume transmission, and the ability to produce a postsynaptic GABAB response after a single presynaptic spike. Using a mouse line expressing green fluorescent protein under the neuropeptide Y promoter, we find that across all layers of CA1, activation of μORs hyperpolarizes Ivy and neurogliaform cells. Further, paired recordings between synaptically coupled Ivy and pyramidal cells show that Ivy cell terminals are dramatically inhibited by μOR-activation. Effects in Ivy and neurogliaform cells are seen at similar concentrations of agonist as those producing inhibition in fast-spiking PV basket cells. We also report that Ivy cells display the recently described phenomenon of persistent firing, a state of continued firing in the absence of continued input, and that induction of persistent firing is inhibited by μOR-activation. Together these findings identify a major, previously unrecognized, target of μOR-modulation. Given the prominence of this cell type in and beyond CA1, as well as its unique role in microcircuitry, opioid modulation of neurogliaform cells has wide implications. PMID:22016519
Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.

PubMed

Krook-Magnuson, Esther; Luu, Lillian; Lee, Sang-Hun; Varga, Csaba; Soltesz, Ivan

2011-10-19

μ-Opioid receptors (μORs) are selectively expressed on interneurons in area CA1 of the hippocampus. Fast-spiking, parvalbumin-expressing, basket cells express μORs, but circumstantial evidence suggests that another major, unidentified, GABAergic cell class must also be modulated by μORs. Here we report that the abundant, dendritically targeting, neurogliaform family of cells (Ivy and neurogliaform cells) is a previously unrecognized target of direct modulation by μORs. Ivy and neurogliaform cells are not only numerous but also have unique properties, including promiscuous gap junctions formed with various interneuronal subtypes, volume transmission, and the ability to produce a postsynaptic GABA(B) response after a single presynaptic spike. Using a mouse line expressing green fluorescent protein under the neuropeptide Y promoter, we find that, across all layers of CA1, activation of μORs hyperpolarizes Ivy and neurogliaform cells. Furthermore, paired recordings between synaptically coupled Ivy and pyramidal cells show that Ivy cell terminals are dramatically inhibited by μOR activation. Effects in Ivy and neurogliaform cells are seen at similar concentrations of agonist as those producing inhibition in fast-spiking parvalbumin basket cells. We also report that Ivy cells display the recently described phenomenon of persistent firing, a state of continued firing in the absence of continued input, and that induction of persistent firing is inhibited by μOR activation. Together, these findings identify a major, previously unrecognized, target of μOR modulation. Given the prominence of this cell type in and beyond CA1, as well as its unique role in microcircuitry, opioid modulation of neurogliaform cells has wide implications.
Integrated RGB laser light module for autostereoscopic outdoor displays

NASA Astrophysics Data System (ADS)

Reitterer, Jörg; Fidler, Franz; Hambeck, Christian; Saint Julien-Wallsee, Ferdinand; Najda, Stephen; Perlin, Piotr; Stanczyk, Szymon; Czernecki, Robert; McDougall, Stewart D.; Meredith, Wyn; Vickers, Garrie; Landles, Kennedy; Schmid, Ulrich

2015-02-01

We have developed highly compact RGB laser light modules to be used as light sources in multi-view autostereoscopic outdoor displays and projection devices. Each light module consists of an AlGaInP red laser diode, a GaInN blue laser diode, a GaInN green laser diode, as well as a common cylindrical microlens. The plano-convex microlens is a so-called "fast axis collimator", which is widely used for collimating light beams emitted from high-power laser diode bars, and has been optimized for polychromatic RGB laser diodes. The three light beams emitted from the red, green, and blue laser diodes are collimated in only one transverse direction, the so-called "fast axis", and in the orthogonal direction, the so-called "slow axis", the beams pass the microlens uncollimated. In the far field of the integrated RGB light module this produces Gaussian beams with a large ellipticity which are required, e.g., for the application in autostereoscopic outdoor displays. For this application only very low optical output powers of a few milliwatts per laser diode are required and therefore we have developed tailored low-power laser diode chips with short cavity lengths of 250 μm for red and 300 μm for blue. Our RGB laser light module including the three laser diode chips, associated monitor photodiodes, the common microlens, as well as the hermetically sealed package has a total volume of only 0.45 cm³, which to our knowledge is the smallest RGB laser light source to date.
Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue

PubMed Central

Karatzaferi, Christina; Adamek, Nancy

2017-01-01

The muscle types present with variable fatigue tolerance, in part due to the myosin isoform expressed. However, the critical steps that define “fatigability” in vivo of fast vs. slow myosin isoforms, at the molecular level, are not yet fully understood. We examined the modulation of the ATP-induced myosin subfragment 1 (S1) dissociation from pyrene-actin by inorganic phosphate (Pi), pH, and temperature using a specially modified stopped-flow system that allowed fast kinetics measurements at physiological temperature. We contrasted the properties of rabbit psoas (fast) and bovine masseter (slow) myosins (obtained from samples collected from New Zealand rabbits and from a licensed abattoir, respectively, according to institutional and national ethics permits). To identify ATP cycling biochemical intermediates, we assessed ATP binding to a preequilibrated mixture of actomyosin and variable [ADP], pH (pH 7 vs. pH 6.2), and Pi (zero, 15, or 30 added mM Pi) in a range of temperatures (5 to 45°C). Temperature and pH variations had little, if any, effect on the ADP dissociation constant (KADP) for fast S1, but for slow S1, KADP was weakened with increasing temperature or low pH. In the absence of ADP, the dissociation constant for phosphate (KPi) was weakened with increasing temperature for fast S1. In the presence of ADP, myosin type differences were revealed at the apparent phosphate affinity, depending on pH and temperature. Overall, the newly revealed kinetic differences between myosin types could help explain the in vivo observed muscle type functional differences at rest and during fatigue. PMID:28931538
Multipathway modulation of exercise and glucose stress effects upon GH secretion in healthy men.

PubMed

Veldhuis, Johannes D; Olson, Thomas P; Takahashi, Paul Y; Miles, John M; Joyner, Michael J; Yang, Rebecca J; Wigham, Jean

2015-09-01

Exercise evokes pulsatile GH release followed by autonegative feedback, whereas glucose suppresses GH release followed by rebound-like GH release (feedforward escape). Here we test the hypothesis that age, sex steroids, insulin, body composition and physical power jointly determine these dynamic GH responses. This was a prospectively randomized glucose-blinded study conducted in the Mayo Center for Advancing Translational Sciences in healthy men ages 19-77 years (N=23). Three conditions, fasting/rest/saline, fasting/exercise/saline and fasting/rest/iv glucose infusions, were used to drive GH dynamics during 10-min blood sampling for 6h. Linear correlation analysis was applied to relate peak/nadir GH dynamics to age, sex steroids, insulin, CT-estimated abdominal fat and physical power (work per unit time). Compared with the fasting/rest/saline (control) day, fasting/exercise/saline infusion evoked peak GH within 1h, followed by negative feedback 3-5h later. The dynamic GH excursion was strongly (R(2)=0.634) influenced by (i) insulin negatively (P=0.011), (ii) power positively (P=0.0008), and (iii) E2 positively (P=0.001). Dynamic glucose-modulated GH release was determined by insulin negatively (P=0.0039) and power positively (P=0.0034) (R(2)=0.454). Under rest/saline, power (P=0.031) and total abdominal fat (P=0.012) (R(2)=0.267) were the dominant correlates of GH excursions. In healthy men, dynamic GH perturbations induced by exercise and glucose are strongly related to physical power, insulin, estradiol, and body composition, thus suggesting a network of regulatory pathways. Copyright © 2015 Elsevier Inc. All rights reserved.
Association between cardiac autonomic function, oxidative stress and inflammatory response in impaired fasting glucose subjects: cross-sectional study.

PubMed

Thiyagarajan, Ramkumar; Subramanian, Senthil Kumar; Sampath, Nishanth; Madanmohan Trakroo; Pal, Pravati; Bobby, Zachariah; Paneerselvam, Sankar; Das, Ashok Kumar

2012-01-01

The worldwide burden of diabetes in 2030 is projected around 552 million. Diabetes leads to higher risk for cardiovascular diseases (CVD). Altered cardiac autonomic function (CAF) measured by heart rate variability (HRV) is observed in early stages of diabetes but the relationship between impaired fasting glucose (IFG) and HRV is still debatable. The aim of the study was to evaluate the association between CAF, oxidative stress, insulin resistance (IR), and inflammatory response in IFG subjects. Cross-sectional blinded study. Volunteers recruited from health awareness camps underwent CAF and biochemical tests. Based on fasting plasma glucose (FPG) participants (n = 123) were divided into two groups, normal fasting glucose (n = 76) and IFG (n = 47). The comparison of parameters between the groups was carried out using student t test and Mann-Whitney U test for parametric and non-parametric data respectively. The correlation between the parameters was analyzed by Spearman's rank correlation using SPSS 13.0. The resting cardiovagal modulation parameters, heart rate response to forced timed breathing, and orthostatic stress were reduced in IFG subjects. Fasting plasma lipid profile, coronary atherogenic lipid risk factors, IR, thiobarbituric acid reactive substance (TBARS), high sensitive C-reactive protein, and tumor necrosis factor alpha were increased and total antioxidant capacity (TAC) was decreased significantly in IFG group but no significant alteration was observed in high-density lipoprotein (HDL-c). Cardiovagal modulation parameters were negatively correlated with triglycerides, FPG, insulin, IR, TBARS, and inflammatory markers and positively with TAC. There is a continuous interplay between the altered CAF, hyperinsulinemia, IR, oxidative stress parameters, inflammatory response, and IFG in which one factor perpetuates another leading to the progression of disease.
A Novel Selective PPARα Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice.

PubMed

Sairyo, Masami; Kobayashi, Takuya; Masuda, Daisaku; Kanno, Koutaro; Zhu, Yinghong; Okada, Takeshi; Koseki, Masahiro; Ohama, Tohru; Nishida, Makoto; Sakata, Yasushi; Yamashita, Shizuya

2018-02-01

Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins and their remnants, which have atherogenic effects. Fibrates can improve fasting and PHTG; however, reduction of remnants is clinically needed to improve health outcomes. In the current study, we investigated the effects of a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), K-877 (Pemafibrate), on PHTG and remnant metabolism. Male C57BL/6J mice were fed a high-fat diet (HFD) only, or an HFD containing 0.0005% K-877 or 0.05% fenofibrate, from 8 to 12 weeks of age. After 4 weeks of feeding, we measured plasma levels of TG, free fatty acids (FFA), total cholesterol (TC), HDL-C, and apolipoprotein (apo) B-48/B-100 during fasting and after oral fat loading (OFL). Plasma lipoprotein profiles after OFL, which were assessed by high performance liquid chromatography (HPLC), and fasting lipoprotein lipase (LPL) activity were compared among the groups. Both K-877 and fenofibrate suppressed body weight gain and fasting and postprandial TG levels and enhanced LPL activity in mice fed an HFD. As determined by HPLC, K-877 and fenofibrate significantly decreased the abundance of TG-rich lipoproteins, including remnants, in postprandial plasma. Both K-877 and fenofibrate decreased intestinal mRNA expression of ApoB and Npc1l1; however, hepatic expression of Srebp1c and Mttp was increased by fenofibrate but not by K-877.Hepatic mRNA expression of apoC-3 was decreased by K-877 but not by fenofibrate. K-877 may attenuate PHTG by suppressing the postprandial increase of chylomicrons and the accumulation of chylomicron remnants more effectively than fenofibrate.
Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons.

PubMed

Roepke, Troy A; Qiu, Jian; Smith, Arik W; Rønnekleiv, Oline K; Kelly, Martin J

2011-08-17

Multiple K(+) conductances are targets for many peripheral and central signals involved in the control of energy homeostasis. Potential K(+) channel targets are the KCNQ subunits that form the channels underlying the M-current, a subthreshold, non-inactivating K(+) current that is a common target for G-protein-coupled receptors. Whole-cell recordings were made from GFP (Renilla)-tagged neuropeptide Y (NPY) neurons from the arcuate nucleus of the hypothalamus using protocols to isolate and characterize the M-current in these orexigenic neurons. We recorded robust K(+) currents in the voltage range of the M-current, which were inhibited by the selective KCNQ channel blocker 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride (XE991) (40 μm), in both intact males and ovariectomized, 17β-estradiol (E2)-treated females. Since NPY neurons are orexigenic and are active during fasting, the M-current was measured in fed and fasted male mice. Fasting attenuated the XE991-sensitive current by threefold, which correlated with decreased expression of the KCNQ2 and KCNQ3 subunits as measured with quantitative real-time PCR. Furthermore, E2 treatment augmented the XE991-sensitive M-current by threefold in ovariectomized (vs oil-treated) female mice. E2 treatment increased the expression of the KCNQ5 subunit in females but not KCNQ2 or KCNQ3 subunits. Fasting in females abrogated the effects of E2 on M-current activity, at least in part, by decreasing KCNQ2 and KCNQ3 expression. In summary, these data suggest that the M-current plays a pivotal role in the modulation of NPY neuronal excitability and may be an important cellular target for neurotransmitter and hormonal signals in the control of energy homeostasis in both males and females.
Retrospective Evaluation of Accelerate Pheno™ System (AXDX, Version 1.1) for Identification/Antimicrobial Susceptibility Testing (ID/AST) of Gram-Negative Bacilli (GNB) including Carbapenemase-Producing Organisms (CPO) from Seeded Blood Culture Bottles (SBCB) Tested using AXDX PhenoTestTM BC Kits

PubMed Central

Willey, Barbara M; Gascon, Bryan; Lee, Samantha; Koren, Vita; Surangiwala, Salman; Paterson, Aimee; Lo, Pauline; Boyd, David A; Mulvey, Michael; Mazzulli, Tony; Poutanen, Susan M

2017-01-01

Abstract Background AXDX reports ID/AST in <7h from positive blood cultures. Prospective pre-FDA clinical trials were conducted in areas where CPO bacteremia was rare. This study challenged AXDX to detect CPO from SBCB. Methods 53 GNB including 31 CPO (10 KPC, 8 OXA48-type, 4 NDM, 3 GES5, 3 VIM, 1 VIM/GES5, 1 IMP7, 1 SME) were tested in AXDX post SBCB incubation in BacT/Alert® (bioMérieux). Seeding suspensions were parallel-tested by CLSI M100-S27 broth microdilution (BMD) for cefazolin (CFZ), ceftriaxone (CRO), ceftazidime (CAZ), piperacillin/tazobactam (TZP), ertapenem (ETP), meropenem (MEM), ciprofloxacin (CIP), gentamicin (GM), tobramycin (TOB), and amikacin (AN). With GNB-genera combined, AXDX-AST were assessed vs BMD using Cumitech 31A for ≥90% agreements [essential (EA); categorical (CA)] and errors [very major (VME) <3%; combined major/minor (ME/mE) <7%]. Results AXDX produced evaluable results (ID-correct/AST-reported) for 83% GNB (19 Klebsiella species; 13 Escherichia coli; 5 Pseudomonas aeruginosa; 4 Enterobacter cloacae, 2 Proteus mirabilis; 1 Serratia marcescens) tabulated below. Limits were exceeded for underlined values, but 95% confidence intervals (CI) overlapped acceptable limits except in values marked with astericks [95% CI: EA (CRO:58.8–85.6; ETP:31.6–61.4; MEM:62.8–87.3; GEN:48.8–76.3); VME (MEM:11.7–45.2); ME/mE (CAZ:7.8–30.3)]. Of 31 CPO, by BMD/AXDX respectively, 2 (6.5%; P. mirabilis NDM, E. coli KPC)/4 (12.9%; same 2 plus E. cloacae KPC, S. marcescens SME) were ETP+MEM=S, 23 (74.2%)/17 (54.8%) were ETP+MEM=I/R and 6 (19.4%; 5 OXA48; 1 KPC)/12 (38.7%; same plus 14 KPC, 1 NDM, 1 SME) were ETP = I/R but MEM=S. If ETP-I/R alone predicted CPO, BMD/AXDX detected 93.5% (95% CI: 78.3–99.2)/87.1% (95% CI: 70.5–95.5) CPO, respectively (P = 0.6713, NS). But as 3/5 (60%) ETP=R non-CPO were also MEM=S by BMD+AXDX, this rule would incur MEM ME. Conclusion Expert rules based on ETP enabled detection of 87.1% (70.5–95.5%) CPO by AXDX in <7h. But while this rule mitigates MEM VME, it risks introducing MEM ME. Further optimization of AXDX algorithms to distinguish challenging CPO growth patterns associated with low carbapenem MIC from non-CPO is underway. More CPO/non-CPO should be tested to tighten 95% CI obtained in this promising study. Disclosures B. M. Willey, Mount Sinai Hospital: Investigator, Educational support S. M. Poutanen, Accelerate Diagnostics: Research Contractor and Scientific Advisor, Consulting fee and Research support
Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

PubMed Central

Liu, Tiemin; Kong, Dong; Shah, Bhavik P.; Ye, Chianping; Koda, Shuichi; Saunders, Arpiar; Ding, Jun B.; Yang, Zongfang; Sabatini, Bernardo L.; Lowell, Bradford B.

2012-01-01

SUMMARY AgRP neuron activity drives feeding and weight gain while that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input in controlling these neurons is unknown. To address this question, we generated mice lacking NMDA receptors (NMDARs) on either AgRP or POMC neurons. Deletion of NMDARs from AgRP neurons markedly reduced weight, body fat and food intake whereas deletion from POMC neurons had no effect. Activation of AgRP neurons by fasting, as assessed by c-Fos, Agrp and Npy mRNA expression, AMPA receptor-mediated EPSCs, depolarization and firing rates, required NMDARs. Furthermore, AgRP but not POMC neurons have dendritic spines and increased glutamatergic input onto AgRP neurons caused by fasting was paralleled by an increase in spines, suggesting fasting induced synaptogenesis and spinogenesis. Thus glutamatergic synaptic transmission and its modulation by NMDARs play key roles in controlling AgRP neurons and determining the cellular and behavioral response to fasting. PMID:22325203
Top-Down Targeted Proteomics Reveals Decrease in Myosin Regulatory Light-Chain Phosphorylation That Contributes to Sarcopenic Muscle Dysfunction.

PubMed

Gregorich, Zachery R; Peng, Ying; Cai, Wenxuan; Jin, Yutong; Wei, Liming; Chen, Albert J; McKiernan, Susan H; Aiken, Judd M; Moss, Richard L; Diffee, Gary M; Ge, Ying

2016-08-05

Sarcopenia, the loss of skeletal muscle mass and function with advancing age, is a significant cause of disability and loss of independence in the elderly and thus, represents a formidable challenge for the aging population. Nevertheless, the molecular mechanism(s) underlying sarcopenia-associated muscle dysfunction remain poorly understood. In this study, we employed an integrated approach combining top-down targeted proteomics with mechanical measurements to dissect the molecular mechanism(s) in age-related muscle dysfunction. Top-down targeted proteomic analysis uncovered a progressive age-related decline in the phosphorylation of myosin regulatory light chain (RLC), a critical protein involved in the modulation of muscle contractility, in the skeletal muscle of aging rats. Top-down tandem mass spectrometry analysis identified a previously unreported bis-phosphorylated proteoform of fast skeletal RLC and localized the sites of decreasing phosphorylation to Ser14/15. Of these sites, Ser14 phosphorylation represents a previously unidentified site of phosphorylation in RLC from fast-twitch skeletal muscle. Subsequent mechanical analysis of single fast-twitch fibers isolated from the muscles of rats of different ages revealed that the observed decline in RLC phosphorylation can account for age-related decreases in the contractile properties of sarcopenic fast-twitch muscles. These results strongly support a role for decreasing RLC phosphorylation in sarcopenia-associated muscle dysfunction and suggest that therapeutic modulation of RLC phosphorylation may represent a new avenue for the treatment of sarcopenia.
Fast wavefront optimization for focusing through biological tissue (Conference Presentation)

NASA Astrophysics Data System (ADS)

Blochet, Baptiste; Bourdieu, Laurent; Gigan, Sylvain

2017-02-01

The propagation of light in biological tissues is rapidly dominated by multiple scattering: ballistic light is exponentially attenuated, which limits the penetration depth of conventional microscopy techniques. For coherent light, the recombination of the different scattered paths creates a complex interference: speckle. Recently, different wavefront shaping techniques have been developed to coherently manipulate the speckle. It opens the possibility to focus light through complex media and ultimately to image in them, provided however that the medium can be considered as stationary. We have studied the possibility to focus in and through time-varying biological tissues. Their intrinsic temporal dynamics creates a fast decorrelation of the speckle pattern. Therefore, focusing through biological tissues requires fast wavefront shaping devices, sensors and algorithms. We have investigated the use of a MEMS-based spatial light modulator (SLM) and a fast photodetector, combined with FPGA electronics to implement a closed-loop optimization. Our optimization process is just limited by the temporal dynamics of the SLM (200µs) and the computation time (45µs), thus corresponding to a rate of 4 kHz. To our knowledge, it's the fastest closed loop optimization using phase modulators. We have studied the focusing through colloidal solutions of TiO2 particles in glycerol, allowing tunable temporal stability, and scattering properties similar to biological tissues. We have shown that our set-up fulfills the required characteristics (speed, enhancement) to focus through biological tissues. We are currently investigating the focusing through acute rat brain slices and the memory effect in dynamic scattering media.
Nootropic agents enhance the recruitment of fast GABAA inhibition in rat neocortex.

PubMed

Ling, Douglas S F; Benardo, Larry S

2005-07-01

It is widely believed that nootropic (cognition-enhancing) agents produce their therapeutic effects by augmenting excitatory synaptic transmission in cortical circuits, primarily through positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors (AMPARs). However, GABA-mediated inhibition is also critical for cognition, and enhanced GABA function may be likewise therapeutic for cognitive disorders. Could nootropics act through such a mechanism as well? To address this question, we examined the effects of nootropic agents on excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) recorded from layer V pyramidal cells in acute slices of somatosensory cortex. Aniracetam, a positive modulator of AMPA/kainate receptors, increased the peak amplitude of evoked EPSCs and the amplitude and duration of polysynaptic fast IPSCs, manifested as a greater total charge carried by IPSCs. As a result, the EPSC/IPSC ratio of total charge was decreased, representing a shift in the excitation-inhibition balance that favors inhibition. Aniracetam did not affect the magnitude of either monosynaptic IPSCs (mono-IPSCs) recorded in the presence of excitatory amino acid receptor antagonists, or miniature IPSCs (mIPSCs) recorded in the presence of tetrodotoxin. However, the duration of both mono-IPSCs and mIPSCs was prolonged, suggesting that aniracetam also directly modulates GABAergic transmission. Cyclothiazide, a preferential modulator of AMPAR function, enhanced the magnitude and duration of polysynaptic IPSCs, similar to aniracetam, but did not affect mono-IPSCs. Concanavalin A, a kainate receptor modulator, had little effect on EPSCs or IPSCs, suggesting there was no contribution from kainate receptor activity. These findings indicate that AMPAR modulators strengthen inhibition in neocortical pyramidal cells, most likely by altering the kinetics of AMPARs on synaptically connected interneurons and possibly by modulating GABA(A) receptor responses in pyramidal cells. This suggests that the therapeutic actions of nootropic agents may be partly mediated through enhanced cortical GABAergic inhibition, and not solely through the direct modification of excitation, as previously thought.
Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

PubMed

Villa-Osaba, Alicia; Gahete, Manuel D; Cordoba-Chacon, José; de Lecea, Luis; Castaño, Justo P; Luque, Raúl M

2016-10-15

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are essential factors in mammary-gland (MG) development and are altered during fasting. However, no studies have investigated the alterations in the expression of GH/IGF-I and its regulatory systems (somatostatin/cortistatin and ghrelin) in MG during fasting. Therefore, this study was aimed at characterizing the regulation of GH/IGF-I/somatostatin/cortistatin/ghrelin-systems expression in MG of fasted female-mice (compared to fed-controls) and the influence of endogenous-cortistatin (using cortistatin-knockouts). Fasting decreased IGF-I while increased IGF-I/Insulin-receptors expression in MGs. Fasting provoked an increase in GH expression that might be associated to enhanced ghrelin-variants/ghrelin-O-acyl-transferase enzyme expression, while an upregulation of somatostatin-receptors was observed. However, cortistatin-knockouts mice showed a decrease in GH and somatostatin receptor-subtypes expression. Altogether, we demonstrate that GH/IGF-I, somatostatin/cortistatin and ghrelin systems expression is altered in MG during fasting, suggesting a relevant role in coordinating its response to metabolic stress, wherein endogenous cortistatin might be essential for an appropriate response. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
Data storage and retrieval system abstract

NASA Technical Reports Server (NTRS)

Matheson, Barbara

1992-01-01

The STX mass storage system design is intended for environments requiring high speed access to large volumes of data (terabyte and greater). Prior to commitment to a product design plan, STX conducted an exhaustive study of the commercially available off-the-shelf hardware and software. STX also conducted research into the area of emerging technologies in networks and storage media so that the design could easily accommodate new interfaces and peripherals as they came on the market. All the selected system elements were brought together in a demo suite sponsored jointly by STX and ALLIANT where the system elements were evaluated based on actual operation using a client-server mirror image configuration. Testing was conducted to assess the various component overheads and results were compared against vendor data claims. The resultant system, while adequate to meet our capacity requirements, fell short of transfer speed expectations. A product team lead by STX was assembled and chartered with solving the bottleneck issues. Optimization efforts yielded a 60 percent improvement in throughput performance. The ALLIANT computer platform provided the I/O flexibility needed to accommodate a multitude of peripheral interfaces including the following: up to twelve 25MB/s VME I/O channels; up to five HiPPI I/O full duplex channels; IPI-s, SCSI, SMD, and RAID disk array support; standard networking software support for TCP/IP, NFS, and FTP; open architecture based on standard RISC processors; and V.4/POSIX-based operating system (Concentrix). All components including the software are modular in design and can be reconfigured as needs and system uses change. Users can begin with a small system and add modules as needed in the field. Most add-ons can be accomplished seamlessly without revision, recompilation or re-linking of software.
Data storage and retrieval system abstract

NASA Astrophysics Data System (ADS)

Matheson, Barbara

1992-09-01

The STX mass storage system design is intended for environments requiring high speed access to large volumes of data (terabyte and greater). Prior to commitment to a product design plan, STX conducted an exhaustive study of the commercially available off-the-shelf hardware and software. STX also conducted research into the area of emerging technologies in networks and storage media so that the design could easily accommodate new interfaces and peripherals as they came on the market. All the selected system elements were brought together in a demo suite sponsored jointly by STX and ALLIANT where the system elements were evaluated based on actual operation using a client-server mirror image configuration. Testing was conducted to assess the various component overheads and results were compared against vendor data claims. The resultant system, while adequate to meet our capacity requirements, fell short of transfer speed expectations. A product team lead by STX was assembled and chartered with solving the bottleneck issues. Optimization efforts yielded a 60 percent improvement in throughput performance. The ALLIANT computer platform provided the I/O flexibility needed to accommodate a multitude of peripheral interfaces including the following: up to twelve 25MB/s VME I/O channels; up to five HiPPI I/O full duplex channels; IPI-s, SCSI, SMD, and RAID disk array support; standard networking software support for TCP/IP, NFS, and FTP; open architecture based on standard RISC processors; and V.4/POSIX-based operating system (Concentrix). All components including the software are modular in design and can be reconfigured as needs and system uses change. Users can begin with a small system and add modules as needed in the field. Most add-ons can be accomplished seamlessly without revision, recompilation or re-linking of software.
Scheme for predictive fault diagnosis in photo-voltaic modules using thermal imaging

NASA Astrophysics Data System (ADS)

Jaffery, Zainul Abdin; Dubey, Ashwani Kumar; Irshad; Haque, Ahteshamul

2017-06-01

Degradation of PV modules can cause excessive overheating which results in a reduced power output and eventually failure of solar panel. To maintain the long term reliability of solar modules and maximize the power output, faults in modules need to be diagnosed at an early stage. This paper provides a comprehensive algorithm for fault diagnosis in solar modules using infrared thermography. Infrared Thermography (IRT) is a reliable, non-destructive, fast and cost effective technique which is widely used to identify where and how faults occurred in an electrical installation. Infrared images were used for condition monitoring of solar modules and fuzzy logic have been used to incorporate intelligent classification of faults. An automatic approach has been suggested for fault detection, classification and analysis. IR images were acquired using an IR camera. To have an estimation of thermal condition of PV module, the faulty panel images were compared to a healthy PV module thermal image. A fuzzy rule-base was used to classify faults automatically. Maintenance actions have been advised based on type of faults.
A Laser Stabilization System for Rydberg Atom Physics

DTIC Science & Technology

2015-09-06

offset locking method which we did. For each system, a small amount of light from a 852 nm (780 nm) diode laser is picked off from the output beam ...this way, tunable sidebands, from 1-10 GHz, that are themselves modulated at .05-5 MHz, can be generated on the input laser beam . The light from the...phase modulation signal. This signal is fed back into the fast (10 MHz bandwidth) locking electronics of the diode laser system to lock the laser to
Solar simulator for concentrator photovoltaic systems.

PubMed

Domínguez, César; Antón, Ignacio; Sala, Gabriel

2008-09-15

A solar simulator for measuring performance of large area concentrator photovoltaic (CPV) modules is presented. Its illumination system is based on a Xenon flash light and a large area collimator mirror, which simulates natural sun light. Quality requirements imposed by the CPV systems have been characterized: irradiance level and uniformity at the receiver, light collimation and spectral distribution. The simulator allows indoor fast and cost-effective performance characterization and classification of CPV systems at the production line as well as module rating carried out by laboratories.
Serum corticosteroid binding globulin expression is modulated by fasting in polar bears (Ursus maritimus).

PubMed

Chow, Brian A; Hamilton, Jason; Cattet, Marc R L; Stenhouse, Gordon; Obbard, Martyn E; Vijayan, Mathilakath M

2011-01-01

Polar bears (Ursus maritimus) from several subpopulations undergo extended fasting during the ice-free season. However, the animals appear to conserve protein despite the prolonged fasting, though the mechanisms involved are poorly understood. We hypothesized that elevated concentrations of corticosteroid binding globulin (CBG), the primary cortisol binding protein in circulation, lead to cortisol resistance and provide a mechanism for protein conservation during extended fasting. The metabolic state (feeding vs. fasting) of 16 field sampled male polar bears was determined based on their serum urea to creatinine ratio (>25 for feeding vs. <5 for fasting). There were no significant differences in serum cortisol levels between all male and female polar bears sampled. Serum CBG expression was greater in lactating females relative to non-lactating females and males. CBG expression was significantly higher in fasting males when compared to non-fasting males. This leads us to suggest that CBG expression may serve as a mechanism to conserve protein during extended fasting in polar bears by reducing systemic free cortisol concentrations. This was further supported by a lower serum glucose concentration in the fasting bears. As well, a lack of an enhanced adrenocortical response to acute capture stress supports our hypothesis that chronic hunger is not a stressor in this species. Overall, our results suggest that elevated serum CBG expression may be an important adaptation to spare proteins by limiting cortisol bioavailability during extended fasting in polar bears. Copyright © 2010 Elsevier Inc. All rights reserved.

Dielectric and physiochemical study of binary mixture of nitrobenzene with toluene

NASA Astrophysics Data System (ADS)

Mohod, Ajay G.; Deshmukh, S. D.; Pattebahadur, K. L.; Undre, P. B.; Patil, S. S.; Khirade, P. W.

2018-05-01

This paper presents the study of binary mixture of Nitrobenzene (NB) with Toluene (TOL) for eleven different concentrations at room temperature. The determined Dielectric Constant (ɛ0) Density (ρ) and Refractive index (nD) values of binary mixture are used to calculate the excess properties i.e. Excess Dielectric Constant (ɛ0E), Excess Molar Volume (VmE), Excess Refractive Index (nDE) and Excess Molar Refraction (RmE) of mixture over the entire composition range and fitted to the Redlich-Kister equation. The Kirkwood Correlation Factor (geff) and other parameters were used to discuss the information about the orientation of dipoles and the solute-solvent interaction of binary mixture at molecular level over the entire range of concentration.
Motion control of 7-DOF arms - The configuration control approach

NASA Technical Reports Server (NTRS)

Seraji, Homayoun; Long, Mark K.; Lee, Thomas S.

1993-01-01

Graphics simulation and real-time implementation of configuration control schemes for a redundant 7-DOF Robotics Research arm are described. The arm kinematics and motion control schemes are described briefly. This is followed by a description of a graphics simulation environment for 7-DOF arm control on the Silicon Graphics IRIS Workstation. Computer simulation results are presented to demonstrate elbow control, collision avoidance, and optimal joint movement as redundancy resolution goals. The laboratory setup for experimental validation of motion control of the 7-DOF Robotics Research arm is then described. The configuration control approach is implemented on a Motorola-68020/VME-bus-based real-time controller, with elbow positioning for redundancy resolution. Experimental results demonstrate the efficacy of configuration control for real-time control.
Effects of seawater transfer and fasting on the endocrine and biochemical growth indices in juvenile chum salmon (Oncorhynchus keta).

PubMed

Taniyama, Natsumi; Kaneko, Nobuto; Inatani, Yu; Miyakoshi, Yasuyuki; Shimizu, Munetaka

2016-09-15

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1 and RNA/DNA ratio are endocrine and biochemical parameters used as growth indices in fish, however, they are subjected to environmental modulation. Chum salmon (Oncorhynchus keta) migrate from freshwater (FW) to seawater (SW) at fry/juvenile stage weighing around 1g and suffer growth-dependent mortality during the early phase of their marine life. In order to reveal environmental modulation of the IGF/IGFBP system and establish a reliable growth index for juvenile chum salmon, we examined effects of SW transfer and fasting on IGF-I, IGFBP-1 and RNA/DNA ratio, and correlated them to individual growth rate. Among serum IGF-I, liver and muscle igf-1, igfbp-1a, igfbp-1b and RNA/DNA ratio examined, muscle RNA/DNA ratio and muscle igfbp-1a responded to SW transfer. Serum IGF-I, liver igf-1 and liver RNA/DNA ratio were sensitive to nutritional change by being reduced in 1week in both FW and SW while muscle igf-1 was reduced 2weeks after fasting. In contrast, igfbp-1a in both tissues was increased by 2weeks of fasting and igfbp-1b in the liver of SW fish was increased in 1week. These results suggest that the sensitivity of igf-1 and igfbp-1s to fasting differs between tissues and subtypes, respectively. When chum salmon juveniles in SW were marked and subjected to feeding or fasting, serum IGF-I showed the highest correlation with individual growth rate. Liver igfbp-1a and -1b, and muscle igf-1 exhibited moderate correlation coefficients with growth rate. These results show that serum IGF-I is superior to the other parameters as a growth index in juvenile chum salmon in term of its stability to salinity change, high sensitivity to fasting and strong relationship with growth rate. On the one hand, when collecting blood from chum salmon fry/juveniles is not practical, measuring liver igfbp-1a and -1b, or/and muscle igf-1 is an alternative. Copyright © 2016 Elsevier Inc. All rights reserved.
Fast Solar Polarimeter: Prototype Characterization and First Results

NASA Astrophysics Data System (ADS)

Iglesias, F. A.; Feller, A.; Krishnappa, N.; Solanki, S. K.

2016-04-01

Due to the differential and non-simultaneous nature of polarization measurements, seeing induced crosstalk (SIC) and seeing limited spatial resolution can easily counterbalance the benefits of solar imaging polarimetry from the ground. The development of instrumental techniques to treat these issues is necessary to fully exploit the next generation of large-aperture solar facilities, and maintain ground-based data at a competitive level with respect to its space-based counterpart. In particular, considering that many open questions in modern solar physics demand data with challenging specifications of resolution and polarimetric sensitivity that can only be achieved with large telescope apertures (Stenflo 1999). Even if state-of-the-art adaptive optics systems greatly improve image quality, their limited correction —due to finite bandwidth, mode number and seeing anisoplanat- ism— produces large residual values of SIC (Krishnappa & Feller 2012). Dual beam polarimeters are commonly used to reduce SIC between the intensity and polarization signals, however, they cannot compensate for the SIC introduced between circular and linear polarization, which can be relevant for high-precision polarimetry. It is known that fast modulation effectively reduces SIC, but the demodulation of the corresponding intensity signals imposes hard requirements on the frame rate of the associated cameras. One way to avoid a fast sensor, is to decouple the camera readout from the intensity demodulation step. This concept is the cornerstone of the very successful Zurich Imaging Polarimeter (ZIMPOL). Even though the ZIMPOL solution allows the detection of very faint signals (˜10-5), its design is not suitable for high-spatial-resolution applications. We are developing a polarimeter that focuses on both spatial resolution (<0.5 arcsec) and polarimetric sensitivity (10-4). The prototype of this Fast Solar Polarimeter (FSP, see Feller et al. 2014), employs a high frame-rate (400 fps), low-noise (<4 e- RMS), pnCCD camera (Hartmann et al. 2006) that is read in synchronization with a polarization modulator based on ferroelectric liquid crystals. The modulator package is similar to the SOLIS (Keller et al. 2003) design and optimized to have an achromatic total polarimetric efficiency above 80 % in the 400-700 nm wavelength range. The fast modulation frequency of FSP, yielding up to 100 full-Stokes measurements per second, and high duty cycle (>95%), have the double benefit of reducing seeing induced artifacts and improving the final spatial resolution by providing an optimal regime for the application of post-facto image reconstruction techniques. In this poster we describe the FSP prototype, including the characterization results, a technique to correct image smearing due to the sensor frame transfer (Iglesias et al. 2015) and some of the first measurements obtained with the 68-cm Vacuum Tower Telescope located at the Observatorio del Teide, Spain.
Real-time detection of fast and thermal neutrons in radiotherapy with CMOS sensors.

PubMed

Arbor, Nicolas; Higueret, Stephane; Elazhar, Halima; Combe, Rodolphe; Meyer, Philippe; Dehaynin, Nicolas; Taupin, Florence; Husson, Daniel

2017-03-07

The peripheral dose distribution is a growing concern for the improvement of new external radiation modalities. Secondary particles, especially photo-neutrons produced by the accelerator, irradiate the patient more than tens of centimeters away from the tumor volume. However the out-of-field dose is still not estimated accurately by the treatment planning softwares. This study demonstrates the possibility of using a specially designed CMOS sensor for fast and thermal neutron monitoring in radiotherapy. The 14 microns-thick sensitive layer and the integrated electronic chain of the CMOS are particularly suitable for real-time measurements in γ/n mixed fields. An experimental field size dependency of the fast neutron production rate, supported by Monte Carlo simulations and CR-39 data, has been observed. This dependency points out the potential benefits of a real-time monitoring of fast and thermal neutron during beam intensity modulated radiation therapies.
Experimental demonstration of a real-time high-throughput digital DC blocker for compensating ADC imperfections in optical fast-OFDM receivers.

PubMed

Zhang, Lu; Ouyang, Xing; Shao, Xiaopeng; Zhao, Jian

2016-06-27

Performance degradation induced by the DC components at the output of real-time analogue-to-digital converter (ADC) is experimentally investigated for optical fast-OFDM receiver. To compensate this degradation, register transfer level (RTL) circuits for real-time digital DC blocker with 20GS/s throughput are proposed and implemented in field programmable gate array (FPGA). The performance of the proposed real-time digital DC blocker is experimentally investigated in a 15Gb/s optical fast-OFDM system with intensity modulation and direct detection over 40 km standard single-mode fibre. The results show that the fixed-point DC blocker has negligible performance penalty compared to the offline floating point one, and can overcome the error floor of the fast OFDM receiver caused by the DC components from the real-time ADC output.
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism

PubMed Central

Gut, Philipp; Baeza-Raja, Bernat; Andersson, Olov; Hasenkamp, Laura; Hsiao, Joseph; Hesselson, Daniel; Akassoglou, Katerina; Verdin, Eric; Hirschey, Matthew D.; Stainier, Didier Y.R.

2012-01-01

Improving the control of energy homeostasis can lower cardiovascular risk in metabolically compromised individuals. To identify new regulators of whole-body energy control, we conducted a high-throughput screen in transgenic reporter zebrafish for small molecules that modulate the expression of the fasting-inducible gluconeogenic gene pck1. We show that this in vivo strategy identified several drugs that impact gluconeogenesis in humans, as well as metabolically uncharacterized compounds. Most notably, we find that the Translocator Protein (TSPO) ligands PK 11195 and Ro5-4864 are glucose lowering agents despite a strong inductive effect on pck1 expression. We show that these drugs are activators of a fasting-like energy state, and importantly that they protect high-fat diet induced obese mice from hepatosteatosis and glucose intolerance, two pathological manifestations of metabolic dysregulation. Thus, using a whole-organism screening strategy, this study has identified new small molecule activators of fasting metabolism. PMID:23201900
100-W 105-μm 0.15NA fiber coupled laser diode module

NASA Astrophysics Data System (ADS)

Karlsen, Scott R.; Price, R. Kirk; Reynolds, Mitch; Brown, Aaron; Mehl, Ron; Patterson, Steve; Martinsen, Robert J.

2009-02-01

We report on the development of a high brightness laser diode module capable of coupling over 100W of optical power into a 105 μm 0.15 NA fiber at 976 nm. This module, based on nLIGHT's Pearl product architecture, utilizes hard soldered single emitters packaged into a compact and passively-cooled package. In this system each diode is individually collimated in the fast and slow axes and free-space coupled into a single fiber. The high brightness module has an optical excitation under 0.13 NA, is virtually free of cladding modes, and has an electrical to optical efficiency greater than 40%. Additionally, this module is compatible with high power 7:1 fused fiber combiners, and initial experiments demonstrated 500W coupled into a 220 μm, 0.22 NA fiber. These modules address the need in the market for higher brightness diode lasers for pumping fiber lasers and direct material processing.
Scientific Verification of Faraday Rotation Modulators: Detection of Diffuse Polarized Galactic Emission

NASA Technical Reports Server (NTRS)

Moyerman, S.; Bierman, E.; Ade, P. A. R.; Aiken, R.; Barkats, D.; Bischoff, C.; Bock, J. J.; Chiang, H. C.; Dowell, C. D.; Duband, L.;

2012-01-01

The design and performance of a wide bandwidth linear polarization-modulator based on the Faraday effect is described. Faraday Rotation Modulators (FRMs) are solid-state polarization switches that are capable of modulation up to approx 10 kHz. Six FRMs were utilized during the 2006 observing season in the Background Imaging of Cosmic Extragalactic Polarization (BICEP) experiment; three FRMs were used at each of BICEP fs 100 and 150 GHz frequency bands. The technology was verified through high signal-to-noise detection of Galactic polarization using two of the six FRMs during four observing runs in 2006. The features exhibit strong agreement with BICEP fs measurements of the Galaxy using non-FRM pixels and with the Galactic polarization models. This marks the first detection of high signal-to-noise mm-wave celestial polarization using fast, active optical modulation. The performance of the FRMs during periods when they were not modulated was also analyzed and compared to results from BICEP fs 43 pixels without FRMs.

Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor alpha1 subunit modulates benzodiazepine binding.

PubMed

Churn, Severn B; Rana, Aniruddha; Lee, Kangmin; Parsons, J Travis; De Blas, Angel; Delorenzo, Robert J

2002-09-01

gamma-Aminobutyric acid (GABA) is the primary neurotransmitter that is responsible for the fast inhibitory synaptic transmission in the central nervous system. A major post-translational mechanism that can rapidly regulate GABAAR function is receptor phosphorylation. This study was designed to test the effect of endogenous calcium and calmodulin-dependent kinase II (CaM kinase II) activation on both allosteric modulator binding and GABAA receptor subunit phosphorylation. Endogenous CaM kinase II activity was stimulated, and GABAA receptors were subsequently analyzed for bothallosteric modulator binding properties and immunoprecipitated and analyzed for subunit phosphorylation levels. A significant increase in allosteric-modulator binding of the GABAAR was observed under conditions maximal for CaM kinase II activation. In addition, CaM kinase II activation resulted in a direct increase in phosphorylation of the GABAA receptor alpha1 subunit. The data suggest that the CaM kinase II-dependent phosphorylation of the GABAA receptor alpha1 subunit modulated allosteric modulator binding to the GABAA receptor.
Simulation of Cascaded Longitudinal-Space-Charge Amplifier at the Fermilab Accelerator Science & Technology (Fast) Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halavanau, A.; Piot, P.

2015-12-01

Cascaded Longitudinal Space Charge Amplifiers (LSCA) have been proposed as a mechanism to generate density modulation over a board spectral range. The scheme has been recently demonstrated in the optical regime and has confirmed the production of broadband optical radiation. In this paper we investigate, via numerical simulations, the performance of a cascaded LSCA beamline at the Fermilab Accelerator Science & Technology (FAST) facility to produce broadband ultraviolet radiation. Our studies are carried out using elegant with included tree-based grid-less space charge algorithm.
Direct diode lasers and their advantages for materials processing and other applications

NASA Astrophysics Data System (ADS)

Fritsche, Haro; Ferrario, Fabio; Koch, Ralf; Kruschke, Bastian; Pahl, Ulrich; Pflueger, Silke; Grohe, Andreas; Gries, Wolfgang; Eibl, Florian; Kohl, Stefanie; Dobler, Michael

2015-03-01

The brightness of diode lasers is improving continuously and has recently started to approach the level of some solid state lasers. The main technology drivers over the last decade were improvements of the diode laser output power and divergence, enhanced optical stacking techniques and system design, and most recently dense spectral combining. Power densities at the work piece exceed 1 MW/cm2 with commercially available industrial focus optics. These power densities are sufficient for cutting and welding as well as ablation. Single emitter based diode laser systems further offer the advantage of fast current modulation due their lower drive current compared to diode bars. Direct diode lasers may not be able to compete with other technologies as fiber or CO2-lasers in terms of maximum power or beam quality. But diode lasers offer a range of features that are not possible to implement in a classical laser. We present an overview of those features that will make the direct diode laser a very valuable addition in the near future, especially for the materials processing market. As the brightness of diode lasers is constantly improving, BPP of less than 5mm*mrad have been reported with multikW output power. Especially single emitter-based diode lasers further offer the advantage of very fast current modulation due to their low drive current and therefore low drive voltage. State of the art diode drivers are already demonstrated with pulse durations of <10μs and repetition rates can be adjusted continuously from several kHz up to cw mode while addressing power levels from 0-100%. By combining trigger signals with analog modulations nearly any kind of pulse form can be realized. Diode lasers also offer a wide, adaptable range of wavelengths, and wavelength stabilization. We report a line width of less than 0.1nm while the wavelength stability is in the range of MHz which is comparable to solid state lasers. In terms of applications, especially our (broad) wavelength combining technology for power scaling opens the window to new processes of cutting or welding and process control. Fast power modulation through direct current control allows pulses of several microseconds with hundreds of watts average power. Spot sizes of less than 100 μm are obtained at the work piece. Such a diode system allows materials processing with a pulse parameter range that is hardly addressed by any other laser system. High productivity material ablation with cost effective lasers is enabled. The wide variety of wavelengths, high brightness, fast power modulation and high efficiency of diode lasers results in a strong pull of existing markets, but also spurs the development of a wide variety of new applications.
Formation Flying of Components of a Large Space Telescope

NASA Technical Reports Server (NTRS)

Mettler, Edward; Quadrelli, Marco; Breckenridge, William

2009-01-01

A conceptual space telescope having an aperture tens of meters wide and a focal length of hundreds of meters would be implemented as a group of six separate optical modules flying in formation: a primary-membrane-mirror module, a relay-mirror module, a focal-plane-assembly module containing a fast steering mirror and secondary and tertiary optics, a primary-mirror-figure-sensing module, a scanning-electron-beam module for controlling the shape of the primary mirror, and a sunshade module. Formation flying would make it unnecessary to maintain the required precise alignments among the modules by means of an impractically massive rigid structure. Instead, a control system operating in conjunction with a metrology system comprising optical and radio subsystems would control the firing of small thrusters on the separate modules to maintain the formation, thereby acting as a virtual rigid structure. The control system would utilize a combination of centralized- and decentralized-control methods according to a leader-follower approach. The feasibility of the concept was demonstrated in computational simulations that showed that relative positions could be maintained to within a fraction of a millimeter and orientations to within several microradians.
Extraction of fast neuronal changes from multichannel functional near-infrared spectroscopy signals using independent component analysis

NASA Astrophysics Data System (ADS)

Morren, Geert; Wolf, Martin; Lemmerling, Philippe; Wolf, Ursula; Choi, Jee H.; Gratton, Enrico; De Lathauwer, Lieven; Van Huffel, Sabine

2002-06-01

Fast changes in the range of milliseconds in the optical properties of cerebral tissue, which are associated with brain activity, can be detected using non-invasive near-infrared spectroscopy (NIRS). These changes in light scattering are due to an alteration in the refractive index at neuronal membranes. The aim of this study was to develop highly sensitive data analysis algorithms to detect this fast signal, which is small compared to other physiological signals. A frequency-domain tissue oximeter, whose laser diodes were modulated at 110MHz was used. The amplitude, mean intensity and phase of the modulated optical signal was measured at 96Hz sample rate. The probe consisting of 4 crossed source detector pairs was placed above the motor cortex, contralateral to the hand performing a tapping exercise consisting of alternating rest- and tapping periods of 20s each. The tapping frequency, which was set to 3.55Hz or 2.5 times the heart rate of the subject to avoid the influence of harmonics on the signal, could not be observed in any of the individual signals measured by the detectors. An adaptive filter was used to remove the arterial pulsatility from the optical signals. Independent Component Analysis allowed to separate signal components in which the tapping frequency was clearly visible.
Effects of motion speed in action representations

PubMed Central

van Dam, Wessel O.; Speed, Laura J.; Lai, Vicky T.; Vigliocco, Gabriella; Desai, Rutvik H.

2017-01-01

Grounded cognition accounts of semantic representation posit that brain regions traditionally linked to perception and action play a role in grounding the semantic content of words and sentences. Sensory-motor systems are thought to support partially abstract simulations through which conceptual content is grounded. However, which details of sensory-motor experience are included in, or excluded from these simulations, is not well understood. We investigated whether sensory-motor brain regions are differentially involved depending on the speed of actions described in a sentence. We addressed this issue by examining the neural signature of relatively fast (The old lady scurried across the road) and slow (The old lady strolled across the road) action sentences. The results showed that sentences that implied fast motion modulated activity within the right posterior superior temporal sulcus and the angular and middle occipital gyri, areas associated with biological motion and action perception. Sentences that implied slow motion resulted in greater signal within the right primary motor cortex and anterior inferior parietal lobule, areas associated with action execution and planning. These results suggest that the speed of described motion influences representational content and modulates the nature of conceptual grounding. Fast motion events are represented more visually whereas motor regions play a greater role in representing conceptual content associated with slow motion. PMID:28160739
Fast multichannel astronomical photometer based on silicon photo multipliers mounted at the Telescopio Nazionale Galileo

NASA Astrophysics Data System (ADS)

Ambrosino, Filippo; Meddi, Franco; Rossi, Corinne; Sclavi, Silvia; Nesci, Roberto; Bruni, Ivan; Ghedina, Adriano; Riverol, Luis; Di Fabrizio, Luca

2014-07-01

The realization of low-cost instruments with high technical performance is a goal that deserves efforts in an epoch of fast technological developments. Such instruments can be easily reproduced and therefore allow new research programs to be opened in several observatories. We realized a fast optical photometer based on the SiPM (Silicon Photo Multiplier) technology, using commercially available modules. Using low-cost components, we developed a custom electronic chain to extract the signal produced by a commercial MPPC (Multi Pixel Photon Counter) module produced by Hamamatsu Photonics to obtain sub-millisecond sampling of the light curve of astronomical sources (typically pulsars). We built a compact mechanical interface to mount the MPPC at the focal plane of the TNG (Telescopio Nazionale Galileo), using the space available for the slits of the LRS (Low Resolution Spectrograph). On February 2014 we observed the Crab pulsar with the TNG with our prototype photometer, deriving its period and the shape of its light curve, in very good agreement with the results obtained in the past with other much more expensive instruments. After the successful run at the telescope we describe here the lessons learned and the ideas that burst to optimize this instrument and make it more versatile.
Transcriptome profiling in fast versus slow-growing rainbow trout across seasonal gradients

USDA-ARS?s Scientific Manuscript database

Background: Circannual rhythms in vertebrates can influence a wide variety of physiological processes. Some notable examples include annual reproductive cycles and for poikilotherms, seasonal changes modulating growth. Increasing water temperature elevates growth rates in fishes, but increases i...
Fast Interrogation of Fiber Bragg Gratings with Electro-Optical Dual Optical Frequency Combs

PubMed Central

Posada-Roman, Julio E.; Garcia-Souto, Jose A.; Poiana, Dragos A.; Acedo, Pablo

2016-01-01

Optical frequency combs (OFC) generated by electro-optic modulation of continuous-wave lasers provide broadband coherent sources with high power per line and independent control of line spacing and the number of lines. In addition to their application in spectroscopy, they offer flexible and optimized sources for the interrogation of other sensors based on wavelength change or wavelength filtering, such as fiber Bragg grating (FBG) sensors. In this paper, a dual-OFC FBG interrogation system based on a single laser and two optical-phase modulators is presented. This architecture allows for the configuration of multimode optical source parameters such as the number of modes and their position within the reflected spectrum of the FBG. A direct read-out is obtained by mapping the optical spectrum onto the radio-frequency spectrum output of the dual-comb. This interrogation scheme is proposed for measuring fast phenomena such as vibrations and ultrasounds. Results are presented for dual-comb operation under optimized control. The optical modes are mapped onto detectable tones that are multiples of 0.5 MHz around a center radiofrequency tone (40 MHz). Measurements of ultrasounds (40 kHz and 120 kHz) are demonstrated with this sensing system. Ultrasounds induce dynamic strain onto the fiber, which generates changes in the reflected Bragg wavelength and, hence, modulates the amplitude of the OFC modes within the reflected spectrum. The amplitude modulation of two counterphase tones is detected to obtain a differential measurement proportional to the ultrasound signal. PMID:27898043
Fast Interrogation of Fiber Bragg Gratings with Electro-Optical Dual Optical Frequency Combs.

PubMed

Posada-Roman, Julio E; Garcia-Souto, Jose A; Poiana, Dragos A; Acedo, Pablo

2016-11-26

Optical frequency combs (OFC) generated by electro-optic modulation of continuous-wave lasers provide broadband coherent sources with high power per line and independent control of line spacing and the number of lines. In addition to their application in spectroscopy, they offer flexible and optimized sources for the interrogation of other sensors based on wavelength change or wavelength filtering, such as fiber Bragg grating (FBG) sensors. In this paper, a dual-OFC FBG interrogation system based on a single laser and two optical-phase modulators is presented. This architecture allows for the configuration of multimode optical source parameters such as the number of modes and their position within the reflected spectrum of the FBG. A direct read-out is obtained by mapping the optical spectrum onto the radio-frequency spectrum output of the dual-comb. This interrogation scheme is proposed for measuring fast phenomena such as vibrations and ultrasounds. Results are presented for dual-comb operation under optimized control. The optical modes are mapped onto detectable tones that are multiples of 0.5 MHz around a center radiofrequency tone (40 MHz). Measurements of ultrasounds (40 kHz and 120 kHz) are demonstrated with this sensing system. Ultrasounds induce dynamic strain onto the fiber, which generates changes in the reflected Bragg wavelength and, hence, modulates the amplitude of the OFC modes within the reflected spectrum. The amplitude modulation of two counterphase tones is detected to obtain a differential measurement proportional to the ultrasound signal.
Image recombination transform algorithm for superresolution structured illumination microscopy

PubMed Central

Zhou, Xing; Lei, Ming; Dan, Dan; Yao, Baoli; Yang, Yanlong; Qian, Jia; Chen, Guangde; Bianco, Piero R.

2016-01-01

Abstract. Structured illumination microscopy (SIM) is an attractive choice for fast superresolution imaging. The generation of structured illumination patterns made by interference of laser beams is broadly employed to obtain high modulation depth of patterns, while the polarizations of the laser beams must be elaborately controlled to guarantee the high contrast of interference intensity, which brings a more complex configuration for the polarization control. The emerging pattern projection strategy is much more compact, but the modulation depth of patterns is deteriorated by the optical transfer function of the optical system, especially in high spatial frequency near the diffraction limit. Therefore, the traditional superresolution reconstruction algorithm for interference-based SIM will suffer from many artifacts in the case of projection-based SIM that possesses a low modulation depth. Here, we propose an alternative reconstruction algorithm based on image recombination transform, which provides an alternative solution to address this problem even in a weak modulation depth. We demonstrated the effectiveness of this algorithm in the multicolor superresolution imaging of bovine pulmonary arterial endothelial cells in our developed projection-based SIM system, which applies a computer controlled digital micromirror device for fast fringe generation and multicolor light-emitting diodes for illumination. The merit of the system incorporated with the proposed algorithm allows for a low excitation intensity fluorescence imaging even less than 1 W/cm2, which is beneficial for the long-term, in vivo superresolved imaging of live cells and tissues. PMID:27653935

Emergence of band-pass filtering through adaptive spiking in the owl's cochlear nucleus

PubMed Central

MacLeod, Katrina M.; Lubejko, Susan T.; Steinberg, Louisa J.; Köppl, Christine; Peña, Jose L.

2014-01-01

In the visual, auditory, and electrosensory modalities, stimuli are defined by first- and second-order attributes. The fast time-pressure signal of a sound, a first-order attribute, is important, for instance, in sound localization and pitch perception, while its slow amplitude-modulated envelope, a second-order attribute, can be used for sound recognition. Ascending the auditory pathway from ear to midbrain, neurons increasingly show a preference for the envelope and are most sensitive to particular envelope modulation frequencies, a tuning considered important for encoding sound identity. The level at which this tuning property emerges along the pathway varies across species, and the mechanism of how this occurs is a matter of debate. In this paper, we target the transition between auditory nerve fibers and the cochlear nucleus angularis (NA). While the owl's auditory nerve fibers simultaneously encode the fast and slow attributes of a sound, one synapse further, NA neurons encode the envelope more efficiently than the auditory nerve. Using in vivo and in vitro electrophysiology and computational analysis, we show that a single-cell mechanism inducing spike threshold adaptation can explain the difference in neural filtering between the two areas. We show that spike threshold adaptation can explain the increased selectivity to modulation frequency, as input level increases in NA. These results demonstrate that a spike generation nonlinearity can modulate the tuning to second-order stimulus features, without invoking network or synaptic mechanisms. PMID:24790170
Thermodynamic modeling of the solar wind plasma in the presence of envelope-modulated low-frequency Alfvén waves

NASA Astrophysics Data System (ADS)

Nariyuki, Y.

2018-06-01

Alfvénic fluctuation is a typical state of the solar wind turbulence. Due to its finite amplitude and envelope modulation, the Alfvénic fluctuation becomes compressible. In the present study, an analytical model of the specific heat ratio in the presence of envelope-modulated Alfvén waves is derived. Ion kinetic effects are modeled by using a semi-ideal (perfect) gas model, in which the specific heat ratio depends on temperature. It is shown that the fourth order polynomial approximation is in good agreement with the kinetic theory. The resultant model is also applied to the fast solar wind plasma.
Enhancing signal detection and completely eliminating scattering using quasi-phase-cycling in 2D IR experiments.

PubMed

Bloem, Robbert; Garrett-Roe, Sean; Strzalka, Halina; Hamm, Peter; Donaldson, Paul

2010-12-20

We demonstrate how quasi-phase-cycling achieved by sub-cycle delay modulation can be used to replace optical chopping in a box-CARS 2D IR experiment in order to enhance the signal size, and, at the same time, completely eliminate any scattering contamination. Two optical devices are described that can be used for this purpose, a wobbling Brewster window and a photoelastic modulator. They are simple to construct, easy to incorporate into any existing 2D IR setup, and have attractive features such as a high optical throughput and a fast modulation frequency needed to phase cycle on a shot-to-shot basis.
Digital, phase-sensitive detection for in situ diode-laser spectroscopy under rapidly changing transmission conditions

NASA Astrophysics Data System (ADS)

Fernholz, T.; Teichert, H.; Ebert, V.

A new harmonic detection scheme for fully digital, fast-scanning wavelength-modulation spectroscopy (DFS-WMS) is presented. DFS-WMS is specially suited for in situ absorption measurements in combustion environments under fast fluctuating transmission conditions and is demonstrated for the first time by open-path monitoring of ambient oxygen using a distributed-feedback diode laser, which is doubly modulated with a fast linear 1 kHz-scan and a sinusoidal 300 kHz-modulation. After an analog high-pass filter, the detector signal is digitized with a 5 megasample/s 12-bit AD-converter card plugged into a PC and subsequently - unlike standard lock-ins - filtered further by co-adding 100 scans, to generate a narrowband comb filter. All further filtering and the demodulation are performed completely digitally on a PC with the help of discrete Fourier transforms (DFT). Both 1f- and 2f-signals, are simultaneously extracted from the detector signal using one ADC input channel. For the 2f-signal, a linearity of 2% and a minimum detectable absorption of 10-4 could be verified experimentally, with the sensitivity to date being limited only by insufficient gain on the 2f-frequency channel. Using the offset in the 1f signal as a transmission `probe', we could show that the 2f-signal can be transmission-corrected by a simple division by the 1f-background, proving that DFS-WMS provides the possibility of compensating for transmission fluctuations. With the inherent suppression of additive noise, DFS-WMS seems well suited for quantitative in situ absorption spectroscopy in large combustion systems. This assumption is supported by the first measurements of oxygen in a high-pressure combustor at 12 bar.
Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations.

PubMed

Hirschmann, Jan; Butz, Markus; Hartmann, Christian J; Hoogenboom, Nienke; Özkurt, Tolga E; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons

2016-10-01

High frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement. The objective of this study was to test whether the power of high-frequency oscillations in the STN is associated with spontaneous manifestation of parkinsonian rest tremor. The electromyogram of both forearms and local field potentials from the STN were recorded in 11 PD patients (10 men, age 58 [9.4] years, disease duration 9.2 [6.3] years). Patients were recorded at rest and while performing repetitive hand movements before and after levodopa intake. High-frequency oscillation power was compared across epochs containing rest tremor, tremor-free rest, or voluntary movement and related to the tremor cycle. We observed prominent slow (200-300 Hz) and fast (300-400 Hz) high-frequency oscillations. The ratio between slow and fast high-frequency oscillation power increased when tremor became manifest. This increase was consistent across nuclei (94%) and occurred in medication ON and OFF. The ratio outperformed other potential markers of tremor, such as power at individual tremor frequency, beta power, or low gamma power. For voluntary movement, we did not observe a significant difference when compared with rest or rest tremor. Finally, rhythmic modulations of high-frequency oscillation power occurred within the tremor cycle. Subthalamic high-frequency oscillation power is closely linked to the occurrence of parkinsonian rest tremor. The balance between slow and fast high-frequency oscillation power combines information on motor and medication state. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.
Proprioceptive reaction times and long-latency reflexes in humans.

PubMed

Manning, C D; Tolhurst, S A; Bawa, P

2012-08-01

The stretch of upper limb muscles results in two electromyographic (EMG) peaks, M1 and M2. The amplitude of M2 peak can generally be modified by giving prior instruction to the subject on how to react to the applied perturbation. The unresolved question is whether the amplitude modulation results from change in the gain of the reflex pathway contributing to M2, or by superposition of reaction time (RT) activity. The following study attempted to resolve this question by examining the overlap between proprioceptive RT and M2 activities. Subject's right wrist flexors were stretched, and he/she was instructed either (1) not to intervene (passive task) or (2) to react as fast as possible by simultaneously flexing both wrists (active or compensate task). Under passive and active conditions, M1 and M2 were observed from EMG of right wrist flexors, and during the active condition, RT activities were additionally observed from both sides. The onset and offset of M2 (M1(onset), M2(offset)) were measured from the passive averages, while the RT was measured from the averaged EMG response of the left wrist flexors. For between-subject correlations, the data were divided into two sets: (1) subjects with RT shorter than M2(offset) (fast group) and (2) subjects with RT more than 10 ms longer than their M2(offset) (slow group). Modulation during M2 period was large for the fast group, and it was almost zero for the slow group. These results indicate that the superimposition of RT activity mainly contributes to the instruction-dependent modulation of M2 peak.
Modulated scattering technique in the terahertz domain enabled by current actuated vanadium dioxide switches

PubMed Central

Vitale, W. A.; Tamagnone, M.; Émond, N.; Le Drogoff, B.; Capdevila, S.; Skrivervik, A.; Chaker, M.; Mosig, J. R.; Ionescu, A. M.

2017-01-01

The modulated scattering technique is based on the use of reconfigurable electromagnetic scatterers, structures able to scatter and modulate an impinging electromagnetic field in function of a control signal. The modulated scattering technique is used in a wide range of frequencies up to millimeter waves for various applications, such as field mapping of circuits or antennas, radio-frequency identification devices and imaging applications. However, its implementation in the terahertz domain remains challenging. Here, we describe the design and experimental demonstration of the modulated scattering technique at terahertz frequencies. We characterize a modulated scatterer consisting in a bowtie antenna loaded with a vanadium dioxide switch, actuated using a continuous current. The modulated scatterer behavior is demonstrated using a time domain terahertz spectroscopy setup and shows significant signal strength well above 0.5 THz, which makes this device a promising candidate for the development of fast and energy-efficient THz communication devices and imaging systems. Moreover, our experiments allowed us to verify the operation of a single micro-meter sized VO2 switch at terahertz frequencies, thanks to the coupling provided by the antenna. PMID:28145523
Acoustic Processing of Temporally Modulated Sounds in Infants: Evidence from a Combined Near-Infrared Spectroscopy and EEG Study

PubMed Central

Telkemeyer, Silke; Rossi, Sonja; Nierhaus, Till; Steinbrink, Jens; Obrig, Hellmuth; Wartenburger, Isabell

2010-01-01

Speech perception requires rapid extraction of the linguistic content from the acoustic signal. The ability to efficiently process rapid changes in auditory information is important for decoding speech and thereby crucial during language acquisition. Investigating functional networks of speech perception in infancy might elucidate neuronal ensembles supporting perceptual abilities that gate language acquisition. Interhemispheric specializations for language have been demonstrated in infants. How these asymmetries are shaped by basic temporal acoustic properties is under debate. We recently provided evidence that newborns process non-linguistic sounds sharing temporal features with language in a differential and lateralized fashion. The present study used the same material while measuring brain responses of 6 and 3 month old infants using simultaneous recordings of electroencephalography (EEG) and near-infrared spectroscopy (NIRS). NIRS reveals that the lateralization observed in newborns remains constant over the first months of life. While fast acoustic modulations elicit bilateral neuronal activations, slow modulations lead to right-lateralized responses. Additionally, auditory-evoked potentials and oscillatory EEG responses show differential responses for fast and slow modulations indicating a sensitivity for temporal acoustic variations. Oscillatory responses reveal an effect of development, that is, 6 but not 3 month old infants show stronger theta-band desynchronization for slowly modulated sounds. Whether this developmental effect is due to increasing fine-grained perception for spectrotemporal sounds in general remains speculative. Our findings support the notion that a more general specialization for acoustic properties can be considered the basis for lateralization of speech perception. The results show that concurrent assessment of vascular based imaging and electrophysiological responses have great potential in the research on language acquisition. PMID:21716574
The relative vertex clustering value - a new criterion for the fast discovery of functional modules in protein interaction networks

PubMed Central

2015-01-01

Background Cellular processes are known to be modular and are realized by groups of proteins implicated in common biological functions. Such groups of proteins are called functional modules, and many community detection methods have been devised for their discovery from protein interaction networks (PINs) data. In current agglomerative clustering approaches, vertices with just a very few neighbors are often classified as separate clusters, which does not make sense biologically. Also, a major limitation of agglomerative techniques is that their computational efficiency do not scale well to large PINs. Finally, PIN data obtained from large scale experiments generally contain many false positives, and this makes it hard for agglomerative clustering methods to find the correct clusters, since they are known to be sensitive to noisy data. Results We propose a local similarity premetric, the relative vertex clustering value, as a new criterion allowing to decide when a node can be added to a given node's cluster and which addresses the above three issues. Based on this criterion, we introduce a novel and very fast agglomerative clustering technique, FAC-PIN, for discovering functional modules and protein complexes from a PIN data. Conclusions Our proposed FAC-PIN algorithm is applied to nine PIN data from eight different species including the yeast PIN, and the identified functional modules are validated using Gene Ontology (GO) annotations from DAVID Bioinformatics Resources. Identified protein complexes are also validated using experimentally verified complexes. Computational results show that FAC-PIN can discover functional modules or protein complexes from PINs more accurately and more efficiently than HC-PIN and CNM, the current state-of-the-art approaches for clustering PINs in an agglomerative manner. PMID:25734691
Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review

PubMed Central

Adawi, Mohammad; Watad, Abdulla; Brown, Stav; Aazza, Khadija; Aazza, Hicham; Zouhir, Mohamed; Sharif, Kassem; Ghanayem, Khaled; Farah, Raymond; Mahagna, Hussein; Fiordoro, Stefano; Sukkar, Samir Giuseppe; Bragazzi, Nicola Luigi; Mahroum, Naim

2017-01-01

Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact on body systems in different manners. The influence of Ramadan fasting on immune system regulation remains elusive; however, immune system changes, such as the modulation of body response to various infectious, stressful, and other harmful events, are of great interest during fasting. In this paper, we performed an extensive systematic literature review of different scholarly databases (ISI/Web of Science, Scopus, PubMed,/MEDLINE, Google Scholar, Directory of Open Access Journals, EbscoHOST, Scirus, Science Direct, the Cochrane Library, and ProQuest), using the following key words: “fasting,” “Ramadan,” “Islam,” and “immunity.” Conclusions drawn from these findings included: (1) Ramadan fasting has been shown to only mildly influence the immune system and the alterations induced are transient, returning to basal pre-Ramadan status shortly afterward. (2) Ramadan fasting during the second trimester of pregnancy was shown to be safe and did not result in negative fetal outcomes, or maternal oxidative status alterations. (3) In cardiac patients, Ramadan fasting can have beneficial effects including lipid profile improvement and alleviation of oxidative stress. (4) In asthmatic patients as well as in patients with human immunodeficiency virus/acquired immunodeficiency syndrome and autoimmune disorders, fasting was safe. (5) In psychiatric patients, such as those suffering from schizophrenia, fasting could increase immunologic markers. (6) Fasting Muslim athletes who maintain intensive training schedule during Ramadan showed fluctuations of immunologic markers. PMID:29230208
Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review.

PubMed

Adawi, Mohammad; Watad, Abdulla; Brown, Stav; Aazza, Khadija; Aazza, Hicham; Zouhir, Mohamed; Sharif, Kassem; Ghanayem, Khaled; Farah, Raymond; Mahagna, Hussein; Fiordoro, Stefano; Sukkar, Samir Giuseppe; Bragazzi, Nicola Luigi; Mahroum, Naim

2017-01-01

Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. All Muslim adults are expected to fast; nevertheless certain subgroups, including sick, frail subjects, and pregnant women, among others, are exempted. Ramadan fasting has been shown to impact on body systems in different manners. The influence of Ramadan fasting on immune system regulation remains elusive; however, immune system changes, such as the modulation of body response to various infectious, stressful, and other harmful events, are of great interest during fasting. In this paper, we performed an extensive systematic literature review of different scholarly databases (ISI/Web of Science, Scopus, PubMed,/MEDLINE, Google Scholar, Directory of Open Access Journals, EbscoHOST, Scirus, Science Direct, the Cochrane Library, and ProQuest), using the following key words: "fasting," "Ramadan," "Islam," and "immunity." Conclusions drawn from these findings included: (1) Ramadan fasting has been shown to only mildly influence the immune system and the alterations induced are transient, returning to basal pre-Ramadan status shortly afterward. (2) Ramadan fasting during the second trimester of pregnancy was shown to be safe and did not result in negative fetal outcomes, or maternal oxidative status alterations. (3) In cardiac patients, Ramadan fasting can have beneficial effects including lipid profile improvement and alleviation of oxidative stress. (4) In asthmatic patients as well as in patients with human immunodeficiency virus/acquired immunodeficiency syndrome and autoimmune disorders, fasting was safe. (5) In psychiatric patients, such as those suffering from schizophrenia, fasting could increase immunologic markers. (6) Fasting Muslim athletes who maintain intensive training schedule during Ramadan showed fluctuations of immunologic markers.
Dietary modulators of statin efficacy in cardiovascular disease and cognition

USDA-ARS?s Scientific Manuscript database

Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and other developed countries, and is fast growing in developing countries, particularly as life expectancy in all parts of the world increases. Current recommendations for the prevention of cardiovascul...
Texturing Silicon Nanowires for Highly Localized Optical Modulation of Cellular Dynamics.

PubMed

Fang, Yin; Jiang, Yuanwen; Acaron Ledesma, Hector; Yi, Jaeseok; Gao, Xiang; Weiss, Dara E; Shi, Fengyuan; Tian, Bozhi

2018-06-18

Engineered silicon-based materials can display photoelectric and photothermal responses under light illumination, which may lead to further innovations at the silicon-biology interfaces. Silicon nanowires have small radial dimensions, promising as highly localized cellular modulators, however the single crystalline form typically has limited photothermal efficacy due to the poor light absorption and fast heat dissipation. In this work, we report strategies to improve the photothermal response from silicon nanowires by introducing nanoscale textures on the surface and in the bulk. We next demonstrate high-resolution extracellular modulation of calcium dynamics in a number of mammalian cells including glial cells, neurons, and cancer cells. The new materials may be broadly used in probing and modulating electrical and chemical signals at the subcellular length scale, which is currently a challenge in the field of electrophysiology or cellular engineering.
OLT-centralized sampling frequency offset compensation scheme for OFDM-PON.

PubMed

Chen, Ming; Zhou, Hui; Zheng, Zhiwei; Deng, Rui; Chen, Qinghui; Peng, Miao; Liu, Cuiwei; He, Jing; Chen, Lin; Tang, Xionggui

2017-08-07

We propose an optical line terminal (OLT)-centralized sampling frequency offset (SFO) compensation scheme for adaptively-modulated OFDM-PON systems. By using the proposed SFO scheme, the phase rotation and inter-symbol interference (ISI) caused by SFOs between OLT and multiple optical network units (ONUs) can be centrally compensated in the OLT, which reduces the complexity of ONUs. Firstly, the optimal fast Fourier transform (FFT) size is identified in the intensity-modulated and direct-detection (IMDD) OFDM system in the presence of SFO. Then, the proposed SFO compensation scheme including phase rotation modulation (PRM) and length-adaptive OFDM frame has been experimentally demonstrated in the downlink transmission of an adaptively modulated optical OFDM with the optimal FFT size. The experimental results show that up to ± 300 ppm SFO can be successfully compensated without introducing any receiver performance penalties.
Photo-generated metamaterials induce modulation of CW terahertz quantum cascade lasers

PubMed Central

Mezzapesa, Francesco P.; Columbo, Lorenzo L.; Rizza, Carlo; Brambilla, Massimo; Ciattoni, Alessardro; Dabbicco, Maurizio; Vitiello, Miriam S.; Scamarcio, Gaetano

2015-01-01

Periodic patterns of photo-excited carriers on a semiconductor surface profoundly modifies its effective permittivity, creating a stationary all-optical quasi-metallic metamaterial. Intriguingly, one can tailor its artificial birefringence to modulate with unprecedented degrees of freedom both the amplitude and phase of a quantum cascade laser (QCL) subject to optical feedback from such an anisotropic reflector. Here, we conceive and devise a reconfigurable photo-designed Terahertz (THz) modulator and exploit it in a proof-of-concept experiment to control the emission properties of THz QCLs. Photo-exciting sub-wavelength metastructures on silicon, we induce polarization-dependent changes in the intra-cavity THz field, that can be probed by monitoring the voltage across the QCL terminals. This inherently flexible approach promises groundbreaking impact on THz photonics applications, including THz phase modulators, fast switches, and active hyperbolic media. PMID:26549166
Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.

PubMed

Cabral-Costa, J V; Andreotti, D Z; Mello, N P; Scavone, C; Camandola, S; Kawamoto, E M

2018-06-05

Phosphatase and tensin homolog (PTEN) is an important protein with key modulatory functions in cell growth and survival. PTEN is crucial during embryogenesis and plays a key role in the central nervous system (CNS), where it directly modulates neuronal development and synaptic plasticity. Loss of PTEN signaling function is associated with cognitive deficits and synaptic plasticity impairment. Accordingly, Pten mutations have a strong link with autism spectrum disorder. In this study, neuronal Pten haploinsufficient male mice were subjected to a long-term environmental intervention - intermittent fasting (IF) - and then evaluated for alterations in exploratory, anxiety and learning and memory behaviors. Although no significant effects on spatial memory were observed, mutant mice showed impaired contextual fear memory in the passive avoidance test - an outcome that was effectively rescued by IF. In this study, we demonstrated that IF modulation, in addition to its rescue of the memory deficit, was also required to uncover behavioral phenotypes otherwise hidden in this neuronal Pten haploinsufficiency model.
Weak beacon detection for air-to-ground optical wireless link establishment.

PubMed

Han, Yaoqiang; Dang, Anhong; Tang, Junxiong; Guo, Hong

2010-02-01

In an air-to-ground free-space optical communication system, strong background interference seriously affects the beacon detection, which makes it difficult to establish the optical link. In this paper, we propose a correlation beacon detection scheme under strong background interference conditions. As opposed to traditional beacon detection schemes, the beacon is modulated by an m-sequence at the transmitting terminal with a digital differential matched filter (DDMF) array introduced at the receiving end to detect the modulated beacon. This scheme is capable of suppressing both strong interference and noise by correlation reception of the received image sequence. In addition, the DDMF array enables each pixel of the image sensor to have its own DDMF of the same structure to process its received image sequence in parallel, thus it makes fast beacon detection possible. Theoretical analysis and an outdoor experiment have been demonstrated and show that the proposed scheme can realize fast and effective beacon detection under strong background interference conditions. Consequently, the required beacon transmission power can also be reduced dramatically.
Linear transformer and primary low-inductance switch and capacitor modules for fast charging of PFL

NASA Astrophysics Data System (ADS)

Bykov, Yu A.; Krastelev, E. G.; Popov, G. V.; Sedin, A. A.; Feduschak, V. F.

2017-05-01

A step-up linear pulse transformer and a modular primary powering system were developed for fast (≈350 ns) charging of a pulse forming line (PFL) of a high-current electron accelerator. The linear transformer is assembled of a set of 20 inductors with circular ferromagnetic cores and one-turn primary windings. The secondary turn is formed by housing tube walls and a voltage adder with a film-glycerol insulation installed inside of the inductors. The primary powering system assembles 10 modules, each of them is a low-inductance site of two capacitors of 0,35 µF and one gas switch mounted at the same enclosure. The total stored energy is 5.5 kJ at the charging voltage of 40 kV. According to test results, the equivalent parameters at the output of the transformer are the next: a capacity - 17.5 nF, an inductance - 2 µH, a resistance - 3.2 Ohms.
The OPERA muon spectrometer tracking electronics

NASA Astrophysics Data System (ADS)

Ambrosio, M.; Barichello, G.; Brugnera, R.; Carrara, E.; Consiglio, L.; Corradi, A.; Dal Corso, F.; Dusini, S.; Felici, G.; Garfagnini, A.; Manea, C.; Masone, V.; Paoloni, A.; Paoluzzi, G.; Papalino, G.; Parascandolo, P.; Sorrentino, G.; Spinetti, M.; Stanco, L.; Terranova, F.; Votano, L.

2004-11-01

The document describes the front-end electronics that instrument the spectrometer of the OPERA experiment. The spectrometer is made of two separate modules. Each module consists of 22 RPC planes equipped with horizontal and vertical strips readout for a total amount of about 25,000 digital channels. The front end electronics is self-triggered and has single plane readout capability. It is made of three different stages: the Front End Boards (FEBs) system, the Controller Boards (CBs) system and the Timing Boards (TBs) system. The FEB system provides discrimination of the strip incoming signals; a FAST OR output of the input signals is also available for trigger plane signal generation. FEBs discriminated signals are acquired by the CBs system that manages also the communication to the experiment DAQ and Slow Control interface. A Trigger Board allows to operate in both self-trigger (the FEB FAST OR signal starts the plane acquisition) or external-trigger (different conditions can be set on the OR signals generated from different planes) modes.
Application of space periodic variation of light polarization in imaging polarimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Drobczynski, Slawomir; Kasprzak, Henryk

The application of space periodic variation of light polarization for measurement and calculation of the distribution of the phase retardation between two eigenwaves propagating inside a linearly birefringent media and the distribution of the azimuth angle of the first eigenvector is described. The measuring method proposed does not require any mechanical movements or rotations of any optical elements. Application of a liquid crystal (LC) modulator instead of a quarter-wave plate gives an opportunity to introduce the required phase shift. The space periodic modulation of the polarization of light is achieved by the use of a Wollaston prism placed inside themore » path of the light beam. Then a fast Fourier transform is used for further calculations. The number of measurements of the light intensity at the output of the system is minimized to two. These assumptions make the proposed method very fast, which is especially important in measurements of the objects with optical anisotropy that is changing in time.« less

Expansion of visual space during optokinetic afternystagmus (OKAN).

PubMed

Kaminiarz, André; Krekelberg, Bart; Bremmer, Frank

2008-05-01

The mechanisms underlying visual perceptual stability are usually investigated using voluntary eye movements. In such studies, errors in perceptual stability during saccades and pursuit are commonly interpreted as mismatches between actual eye position and eye-position signals in the brain. The generality of this interpretation could in principle be tested by investigating spatial localization during reflexive eye movements whose kinematics are very similar to those of voluntary eye movements. Accordingly, in this study, we determined mislocalization of flashed visual targets during optokinetic afternystagmus (OKAN). These eye movements are quite unique in that they occur in complete darkness and are generated by subcortical control mechanisms. We found that during horizontal OKAN slow phases, subjects mislocalize targets away from the fovea in the horizontal direction. This corresponds to a perceived expansion of visual space and is unlike mislocalization found for any other voluntary or reflexive eye movement. Around the OKAN fast phases, we found a bias in the direction of the fast phase prior to its onset and opposite to the fast-phase direction thereafter. Such a biphasic modulation has also been reported in the temporal vicinity of saccades and during optokinetic nystagmus (OKN). A direct comparison, however, showed that the modulation during OKAN was much larger and occurred earlier relative to fast-phase onset than during OKN. A simple mismatch between the current eye position and the eye-position signal in the brain is unlikely to explain such disparate results across similar eye movements. Instead, these data support the view that mislocalization arises from errors in eye-centered position information.
Device and method for relativistic electron beam heating of a high-density plasma to drive fast liners

DOEpatents

Thode, Lester E.

1981-01-01

A device and method for relativistic electron beam heating of a high-density plasma in a small localized region. A relativistic electron beam generator or accelerator produces a high-voltage electron beam which propagates along a vacuum drift tube and is modulated to initiate electron bunching within the beam. The beam is then directed through a low-density gas chamber which provides isolation between the vacuum modulator and the relativistic electron beam target. The relativistic beam is then applied to a high-density target plasma which typically comprises DT, DD, hydrogen boron or similar thermonuclear gas at a density of 10.sup.17 to 10.sup.20 electrons per cubic centimeter. The target gas is ionized prior to application of the electron beam by means of a laser or other preionization source to form a plasma. Utilizing a relativistic electron beam with an individual particle energy exceeding 3 MeV, classical scattering by relativistic electrons passing through isolation foils is negligible. As a result, relativistic streaming instabilities are initiated within the high-density target plasma causing the relativistic electron beam to efficiently deposit its energy and momentum into a small localized region of the high-density plasma target. Fast liners disposed in the high-density target plasma are explosively or ablatively driven to implosion by a heated annular plasma surrounding the fast liner which is generated by an annular relativistic electron beam. An azimuthal magnetic field produced by axial current flow in the annular plasma, causes the energy in the heated annular plasma to converge on the fast liner.
One-trial overshadowing: Evidence for fast specific fear learning in humans.

PubMed

Haesen, Kim; Beckers, Tom; Baeyens, Frank; Vervliet, Bram

2017-03-01

Adaptive defensive actions necessitate a fear learning system that is both fast and specific. Fast learning serves to minimize the number of threat confrontations, while specific learning ensures that the acquired fears are tied to threat-relevant cues only. In Pavlovian fear conditioning, fear acquisition is typically studied via repetitive pairings of a single cue with an aversive experience, which is not optimal for the examination of fast specific fear learning. In this study, we adopted the one-trial overshadowing procedure from basic learning research, in which a combination of two visual cues is presented once and paired with an aversive electrical stimulation. Using on-line shock expectancy ratings, skin conductance reactivity and startle reflex modulation as indices of fear learning, we found evidence of strong fear after a single conditioning trial (fast learning) as well as attenuated fear responding when only half of the trained stimulus combination was presented (specific learning). Moreover, specificity of fear responding tended to correlate with levels of state and trait anxiety. These results suggest that one-trial overshadowing can be used as a model to study fast specific fear learning in humans and individual differences therein. Copyright © 2016 Elsevier Ltd. All rights reserved.
Reduced Fluorescent Protein Switching Fatigue by Binding-Induced Emissive State Stabilization

PubMed Central

Dedecker, Peter

2017-01-01

Reversibly switchable fluorescent proteins (RSFPs) enable advanced fluorescence imaging, though the performance of this imaging crucially depends on the properties of the labels. We report on the use of an existing small binding peptide, named Enhancer, to modulate the spectroscopic properties of the recently developed rsGreen series of RSFPs. Fusion constructs of Enhancer with rsGreen1 and rsGreenF revealed an increased molecular brightness and pH stability, although expression in living E. coli or HeLa cells resulted in a decrease of the overall emission. Surprisingly, Enhancer binding also increased off-switching speed and resistance to switching fatigue. Further investigation suggested that the RSFPs can interconvert between fast- and slow-switching emissive states, with the overall protein population gradually converting to the slow-switching state through irradiation. The Enhancer modulates the spectroscopic properties of both states, but also preferentially stabilizes the fast-switching state, supporting the increased fatigue resistance. This work demonstrates how the photo-physical properties of RSFPs can be influenced by their binding to other small proteins, which opens up new horizons for applications that may require such modulation. Furthermore, we provide new insights into the photoswitching kinetics that should be of general consideration when developing new RSFPs with improved or different photochromic properties. PMID:28930199
STDP allows fast rate-modulated coding with Poisson-like spike trains.

PubMed

Gilson, Matthieu; Masquelier, Timothée; Hugues, Etienne

2011-10-01

Spike timing-dependent plasticity (STDP) has been shown to enable single neurons to detect repeatedly presented spatiotemporal spike patterns. This holds even when such patterns are embedded in equally dense random spiking activity, that is, in the absence of external reference times such as a stimulus onset. Here we demonstrate, both analytically and numerically, that STDP can also learn repeating rate-modulated patterns, which have received more experimental evidence, for example, through post-stimulus time histograms (PSTHs). Each input spike train is generated from a rate function using a stochastic sampling mechanism, chosen to be an inhomogeneous Poisson process here. Learning is feasible provided significant covarying rate modulations occur within the typical timescale of STDP (~10-20 ms) for sufficiently many inputs (~100 among 1000 in our simulations), a condition that is met by many experimental PSTHs. Repeated pattern presentations induce spike-time correlations that are captured by STDP. Despite imprecise input spike times and even variable spike counts, a single trained neuron robustly detects the pattern just a few milliseconds after its presentation. Therefore, temporal imprecision and Poisson-like firing variability are not an obstacle to fast temporal coding. STDP provides an appealing mechanism to learn such rate patterns, which, beyond sensory processing, may also be involved in many cognitive tasks.
Overview of diagnostic performance and results for the first operation phase in Wendelstein 7-X (invited).

PubMed

Krychowiak, M; Adnan, A; Alonso, A; Andreeva, T; Baldzuhn, J; Barbui, T; Beurskens, M; Biel, W; Biedermann, C; Blackwell, B D; Bosch, H S; Bozhenkov, S; Brakel, R; Bräuer, T; Brotas de Carvalho, B; Burhenn, R; Buttenschön, B; Cappa, A; Cseh, G; Czarnecka, A; Dinklage, A; Drews, P; Dzikowicka, A; Effenberg, F; Endler, M; Erckmann, V; Estrada, T; Ford, O; Fornal, T; Frerichs, H; Fuchert, G; Geiger, J; Grulke, O; Harris, J H; Hartfuß, H J; Hartmann, D; Hathiramani, D; Hirsch, M; Höfel, U; Jabłoński, S; Jakubowski, M W; Kaczmarczyk, J; Klinger, T; Klose, S; Knauer, J; Kocsis, G; König, R; Kornejew, P; Krämer-Flecken, A; Krawczyk, N; Kremeyer, T; Książek, I; Kubkowska, M; Langenberg, A; Laqua, H P; Laux, M; Lazerson, S; Liang, Y; Liu, S C; Lorenz, A; Marchuk, A O; Marsen, S; Moncada, V; Naujoks, D; Neilson, H; Neubauer, O; Neuner, U; Niemann, H; Oosterbeek, J W; Otte, M; Pablant, N; Pasch, E; Sunn Pedersen, T; Pisano, F; Rahbarnia, K; Ryć, L; Schmitz, O; Schmuck, S; Schneider, W; Schröder, T; Schuhmacher, H; Schweer, B; Standley, B; Stange, T; Stephey, L; Svensson, J; Szabolics, T; Szepesi, T; Thomsen, H; Travere, J-M; Trimino Mora, H; Tsuchiya, H; Weir, G M; Wenzel, U; Werner, A; Wiegel, B; Windisch, T; Wolf, R; Wurden, G A; Zhang, D; Zimbal, A; Zoletnik, S

2016-11-01

Wendelstein 7-X, a superconducting optimized stellarator built in Greifswald/Germany, started its first plasmas with the last closed flux surface (LCFS) defined by 5 uncooled graphite limiters in December 2015. At the end of the 10 weeks long experimental campaign (OP1.1) more than 20 independent diagnostic systems were in operation, allowing detailed studies of many interesting plasma phenomena. For example, fast neutral gas manometers supported by video cameras (including one fast-frame camera with frame rates of tens of kHz) as well as visible cameras with different interference filters, with field of views covering all ten half-modules of the stellarator, discovered a MARFE-like radiation zone on the inboard side of machine module 4. This structure is presumably triggered by an inadvertent plasma-wall interaction in module 4 resulting in a high impurity influx that terminates some discharges by radiation cooling. The main plasma parameters achieved in OP1.1 exceeded predicted values in discharges of a length reaching 6 s. Although OP1.1 is characterized by short pulses, many of the diagnostics are already designed for quasi-steady state operation of 30 min discharges heated at 10 MW of ECRH. An overview of diagnostic performance for OP1.1 is given, including some highlights from the physics campaigns.
Multidimensional discrete compactons in nonlinear Schrödinger lattices with strong nonlinearity management

DOE Office of Scientific and Technical Information (OSTI.GOV)

D'Ambroise, J.; Salerno, M.; Kevrekidis, P. G.

The existence of multidimensional lattice compactons in the discrete nonlinear Schrödinger equation in the presence of fast periodic time modulations of the nonlinearity is demonstrated. By averaging over the period of the fast modulations, an effective averaged dynamical equation arises with coupling constants involving Bessel functions of the first and zeroth kinds. We show that these terms allow one to solve, at this averaged level, for exact discrete compacton solution configurations in the corresponding stationary equation. We focus on seven types of compacton solutions. Single-site and vortex solutions are found to be always stable in the parametric regimes we examined.more » We also found that other solutions such as double-site in- and out-of-phase, four-site symmetric and antisymmetric, and a five-site compacton solution are found to have regions of stability and instability in two-dimensional parametric planes, involving variations of the strength of the coupling and of the nonlinearity. We also explore the time evolution of the solutions and compare the dynamics according to the averaged equations with those of the original dynamical system. Finally, the possible observation of compactons in Bose-Einstein condensates loaded in a deep two-dimensional optical lattice with interactions modulated periodically in time is also discussed.« less
A binary link tracker for the BaBar level 1 trigger system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berenyi, A.; Chen, H.K.; Dao, K.

1999-08-01

The BaBar detector at PEP-II will operate in a high-luminosity e{sup +}e{sup {minus}} collider environment near the {Upsilon}(4S) resonance with the primary goal of studying CP violation in the B meson system. In this environment, typical physics events of interest involve multiple charged particles. These events are identified by counting these tracks in a fast first level (Level 1) trigger system, by reconstructing the tracks in real time. For this purpose, a Binary Link Tracker Module (BLTM) was designed and fabricated for the BaBar Level 1 Drift Chamber trigger system. The BLTM is responsible for linking track segments, constructed bymore » the Track Segment Finder Modules (TSFM), into complete tracks. A single BLTM module processes a 360 MBytes/s stream of segment hit data, corresponding to information from the entire Drift Chamber, and implements a fast and robust algorithm that tolerates high hit occupancies as well as local inefficiencies of the Drift Chamber. The algorithms and the necessary control logic of the BLTM were implemented in Field Programmable Gate Arrays (FPGAs), using the VHDL hardware description language. The finished 9U x 400 mm Euro-format board contains roughly 75,000 gates of programmable logic or about 10,000 lines of VHDL code synthesized into five FPGAs.« less
Using individual differences to test the role of temporal and place cues in coding frequency modulation

PubMed Central

Whiteford, Kelly L.; Oxenham, Andrew J.

2015-01-01

The question of how frequency is coded in the peripheral auditory system remains unresolved. Previous research has suggested that slow rates of frequency modulation (FM) of a low carrier frequency may be coded via phase-locked temporal information in the auditory nerve, whereas FM at higher rates and/or high carrier frequencies may be coded via a rate-place (tonotopic) code. This hypothesis was tested in a cohort of 100 young normal-hearing listeners by comparing individual sensitivity to slow-rate (1-Hz) and fast-rate (20-Hz) FM at a carrier frequency of 500 Hz with independent measures of phase-locking (using dynamic interaural time difference, ITD, discrimination), level coding (using amplitude modulation, AM, detection), and frequency selectivity (using forward-masking patterns). All FM and AM thresholds were highly correlated with each other. However, no evidence was obtained for stronger correlations between measures thought to reflect phase-locking (e.g., slow-rate FM and ITD sensitivity), or between measures thought to reflect tonotopic coding (fast-rate FM and forward-masking patterns). The results suggest that either psychoacoustic performance in young normal-hearing listeners is not limited by peripheral coding, or that similar peripheral mechanisms limit both high- and low-rate FM coding. PMID:26627783
Using individual differences to test the role of temporal and place cues in coding frequency modulation.

PubMed

Whiteford, Kelly L; Oxenham, Andrew J

2015-11-01

The question of how frequency is coded in the peripheral auditory system remains unresolved. Previous research has suggested that slow rates of frequency modulation (FM) of a low carrier frequency may be coded via phase-locked temporal information in the auditory nerve, whereas FM at higher rates and/or high carrier frequencies may be coded via a rate-place (tonotopic) code. This hypothesis was tested in a cohort of 100 young normal-hearing listeners by comparing individual sensitivity to slow-rate (1-Hz) and fast-rate (20-Hz) FM at a carrier frequency of 500 Hz with independent measures of phase-locking (using dynamic interaural time difference, ITD, discrimination), level coding (using amplitude modulation, AM, detection), and frequency selectivity (using forward-masking patterns). All FM and AM thresholds were highly correlated with each other. However, no evidence was obtained for stronger correlations between measures thought to reflect phase-locking (e.g., slow-rate FM and ITD sensitivity), or between measures thought to reflect tonotopic coding (fast-rate FM and forward-masking patterns). The results suggest that either psychoacoustic performance in young normal-hearing listeners is not limited by peripheral coding, or that similar peripheral mechanisms limit both high- and low-rate FM coding.
STDP Allows Fast Rate-Modulated Coding with Poisson-Like Spike Trains

PubMed Central

Hugues, Etienne

2011-01-01

Spike timing-dependent plasticity (STDP) has been shown to enable single neurons to detect repeatedly presented spatiotemporal spike patterns. This holds even when such patterns are embedded in equally dense random spiking activity, that is, in the absence of external reference times such as a stimulus onset. Here we demonstrate, both analytically and numerically, that STDP can also learn repeating rate-modulated patterns, which have received more experimental evidence, for example, through post-stimulus time histograms (PSTHs). Each input spike train is generated from a rate function using a stochastic sampling mechanism, chosen to be an inhomogeneous Poisson process here. Learning is feasible provided significant covarying rate modulations occur within the typical timescale of STDP (∼10–20 ms) for sufficiently many inputs (∼100 among 1000 in our simulations), a condition that is met by many experimental PSTHs. Repeated pattern presentations induce spike-time correlations that are captured by STDP. Despite imprecise input spike times and even variable spike counts, a single trained neuron robustly detects the pattern just a few milliseconds after its presentation. Therefore, temporal imprecision and Poisson-like firing variability are not an obstacle to fast temporal coding. STDP provides an appealing mechanism to learn such rate patterns, which, beyond sensory processing, may also be involved in many cognitive tasks. PMID:22046113
Multidimensional discrete compactons in nonlinear Schrödinger lattices with strong nonlinearity management

DOE PAGES

D'Ambroise, J.; Salerno, M.; Kevrekidis, P. G.; ...

2015-11-19

The existence of multidimensional lattice compactons in the discrete nonlinear Schrödinger equation in the presence of fast periodic time modulations of the nonlinearity is demonstrated. By averaging over the period of the fast modulations, an effective averaged dynamical equation arises with coupling constants involving Bessel functions of the first and zeroth kinds. We show that these terms allow one to solve, at this averaged level, for exact discrete compacton solution configurations in the corresponding stationary equation. We focus on seven types of compacton solutions. Single-site and vortex solutions are found to be always stable in the parametric regimes we examined.more » We also found that other solutions such as double-site in- and out-of-phase, four-site symmetric and antisymmetric, and a five-site compacton solution are found to have regions of stability and instability in two-dimensional parametric planes, involving variations of the strength of the coupling and of the nonlinearity. We also explore the time evolution of the solutions and compare the dynamics according to the averaged equations with those of the original dynamical system. Finally, the possible observation of compactons in Bose-Einstein condensates loaded in a deep two-dimensional optical lattice with interactions modulated periodically in time is also discussed.« less
Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism

PubMed Central

Kim, Hyunbae; Mendez, Roberto; Chen, Xuequn; Fang, Deyu

2015-01-01

Cyclic AMP-responsive element-binding protein 3-like 3, hepatocyte specific (CREBH), is a hepatic transcription factor that functions as a key regulator of energy homeostasis. Here, we defined a regulatory CREBH posttranslational modification process, namely, lysine-specific acetylation, and its functional involvement in fasting-induced hepatic lipid metabolism. Fasting induces CREBH acetylation in mouse livers in a time-dependent manner, and this event is critical for CREBH transcriptional activity in regulating hepatic lipid homeostasis. The histone acetyltransferase PCAF-mediated acetylation and the deacetylase sirtuin-1-mediated deacetylation coexist to maintain CREBH acetylation states under fasting conditions. Site-directed mutagenesis and functional analyses revealed that the lysine (K) residue at position 294 (K294) within the bZIP domain of the CREBH protein is the site where fasting-induced acetylation/deacetylation occurs. Introduction of the acetylation-deficient (K294R) or acetylation-mimicking (K294Q) mutation inhibited or enhanced CREBH transcriptional activity, respectively. Importantly, CREBH acetylation at lysine 294 was required for the interaction and synergy between CREBH and peroxisome proliferator-activated receptor α (PPARα) in activating their target genes upon fasting or glucagon stimulation. Introduction of the CREBH lysine 294 mutation in the liver leads to hepatic steatosis and hyperlipidemia in animals under prolonged fasting. In summary, our study reveals a molecular mechanism by which fasting or glucagon stimulation modulates lipid homeostasis through acetylation of CREBH. PMID:26438600
[The future of telepathology. An Internet "distributed system" with "open standards"].

PubMed

Brauchli, K; Helfrich, M; Christen, H; Jundt, G; Haroske, G; Mihatsch, M; Oberli, H; Oberholzer, M

2002-05-01

With the availability of Internet, the interest in the possibilities of telepathology has increased considerably. In the foreground is thereby the need of the non-expert to bring in the opinions of experts on morphological findings by means of a fast and simple procedure. The new telepathology system iPath is in compliance with these needs. The system is based on small, but when possible independently working modules. This concept allows a simple adaptation of the system to the individual environment of the user (e.g. for different cameras, frame-grabbers, microscope steering tables etc.) and for individual needs. iPath has been in use for 6 months with various working groups. In telepathology a distinction is made between "passive" and "active" consultations but for both forms a non-expert brings in the opinion of an expert. In an active consultation both are in direct connection with each other (orally or via a chat-function), this is however not the case with a passive consultation. An active consultation can include the interactive discussion of the expert with the non-expert on images in an image database or the direct interpretation of images from a microscope by the expert. Four software modules are available for a free and as fast as possible application: (1) the module "Microscope control", (2) the module "Connector" (insertion of images directly from the microscope without a motorized microscope), (3) the module "Client-application" via the web-browser and (4) the module "Server" with a database. The server is placed in the internet and not behind a firewall. The server permanently receives information from the periphery and returns the information to the periphery on request. The only thing which the expert, the non-expert and the microscope have to know is how contact can made with the server.
Aerial projection of three-dimensional motion pictures by electro-holography and parabolic mirrors.

PubMed

Kakue, Takashi; Nishitsuji, Takashi; Kawashima, Tetsuya; Suzuki, Keisuke; Shimobaba, Tomoyoshi; Ito, Tomoyoshi

2015-07-08

We demonstrate an aerial projection system for reconstructing 3D motion pictures based on holography. The system consists of an optical source, a spatial light modulator corresponding to a display and two parabolic mirrors. The spatial light modulator displays holograms calculated by computer and can reconstruct holographic motion pictures near the surface of the modulator. The two parabolic mirrors can project floating 3D images of the motion pictures formed by the spatial light modulator without mechanical scanning or rotating. In this demonstration, we used a phase-modulation-type spatial light modulator. The number of pixels and the pixel pitch of the modulator were 1,080 × 1,920 and 8.0 μm × 8.0 μm, respectively. The diameter, the height and the focal length of each parabolic mirror were 288 mm, 55 mm and 100 mm, respectively. We succeeded in aerially projecting 3D motion pictures of size ~2.5 mm(3) by this system constructed by the modulator and mirrors. In addition, by applying a fast computational algorithm for holograms, we achieved hologram calculations at ~12 ms per hologram with 4 CPU cores.
Aerial projection of three-dimensional motion pictures by electro-holography and parabolic mirrors

PubMed Central

Kakue, Takashi; Nishitsuji, Takashi; Kawashima, Tetsuya; Suzuki, Keisuke; Shimobaba, Tomoyoshi; Ito, Tomoyoshi

2015-01-01

We demonstrate an aerial projection system for reconstructing 3D motion pictures based on holography. The system consists of an optical source, a spatial light modulator corresponding to a display and two parabolic mirrors. The spatial light modulator displays holograms calculated by computer and can reconstruct holographic motion pictures near the surface of the modulator. The two parabolic mirrors can project floating 3D images of the motion pictures formed by the spatial light modulator without mechanical scanning or rotating. In this demonstration, we used a phase-modulation-type spatial light modulator. The number of pixels and the pixel pitch of the modulator were 1,080 × 1,920 and 8.0 μm × 8.0 μm, respectively. The diameter, the height and the focal length of each parabolic mirror were 288 mm, 55 mm and 100 mm, respectively. We succeeded in aerially projecting 3D motion pictures of size ~2.5 mm3 by this system constructed by the modulator and mirrors. In addition, by applying a fast computational algorithm for holograms, we achieved hologram calculations at ~12 ms per hologram with 4 CPU cores. PMID:26152453
Sensitivity of human auditory cortex to rapid frequency modulation revealed by multivariate representational similarity analysis.

PubMed

Joanisse, Marc F; DeSouza, Diedre D

2014-01-01

Functional Magnetic Resonance Imaging (fMRI) was used to investigate the extent, magnitude, and pattern of brain activity in response to rapid frequency-modulated sounds. We examined this by manipulating the direction (rise vs. fall) and the rate (fast vs. slow) of the apparent pitch of iterated rippled noise (IRN) bursts. Acoustic parameters were selected to capture features used in phoneme contrasts, however the stimuli themselves were not perceived as speech per se. Participants were scanned as they passively listened to sounds in an event-related paradigm. Univariate analyses revealed a greater level and extent of activation in bilateral auditory cortex in response to frequency-modulated sweeps compared to steady-state sounds. This effect was stronger in the left hemisphere. However, no regions showed selectivity for either rate or direction of frequency modulation. In contrast, multivoxel pattern analysis (MVPA) revealed feature-specific encoding for direction of modulation in auditory cortex bilaterally. Moreover, this effect was strongest when analyses were restricted to anatomical regions lying outside Heschl's gyrus. We found no support for feature-specific encoding of frequency modulation rate. Differential findings of modulation rate and direction of modulation are discussed with respect to their relevance to phonetic discrimination.
KSC-03pd0105

NASA Image and Video Library

2003-01-16

KENNEDY SPACE CENTER, FLA. - STS-107 Payload Commander Michael Anderson is happy to being suiting up for launch on mission STS-107. The mission is devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. The payload on Space Shuttle Columbia includes FREESTAR (Fast Reaction Experiments Enabling Science, Technology, Applications and Research) and the SHI Research Double Module (SHI/RDM), known as SPACEHAB. Experiments on the module range from material sciences to life sciences. Liftoff is scheduled for 10:39 a.m. EST.
Applications of variable focus liquid lenses for curvature wave-front sensors in astronomy

NASA Astrophysics Data System (ADS)

Fuentes-Fernández, J.; Cuevas, S.; Alvarez-Nuñez, L. C.; Watson, A. M.

2014-08-01

Curvature wavefront sensors obtain the wave-front aberrations from two defocused intensity images at each side of the pupil plane. Typically, when high modulation speeds are required, as it is the case with Adaptive Optics, that defocusing is done with a fast vibrating membrane mirror. We propose an alternative defocusing mechanism based on an electrowetting variable focus liquid lens. The use of such lenses may perform the required focus modulation without the need of extra moving parts, reducing the overall size of the system.
IEEE Conference Record of 1973 Eleventh Modulator Symposium, New York City, 18-19 September 1973.

DTIC Science & Technology

1973-01-01

characteristics of High-Voltage, observed on am NPNP structure of 550 uN base thickness High- Power , Fast-Switching, Reverse- operating at 1.3 Kv I IA I KA/ us 30...of this which supplies four CFA’s. The odd-numered compact modulator are a shunt clamp regulator power supplies have an additional output going to a...three driver of HVPS filter banks. cabinets. Thus four of the power supplies have a 50% greater load than the other four. However, in AEGIS SPY-1

Evaluating the coherence and time-domain profile of quantum cascade laser frequency combs

DOE PAGES

Burghoff, David; Yang, Yang; Hayton, Darren J.; ...

2015-01-01

Recently, much attention has been focused on the generation of optical frequency combs from quantum cascade lasers. We discuss how fast detectors can be used to demonstrate the mutual coherence of such combs, and present an inequality that can be used to quantitatively evaluate their performance. We discuss several technical issues related to shifted wave interference Fourier Transform spectroscopy (SWIFTS), and show how such measurements can be used to elucidate the time-domain properties of such combs, showing that they can possess signatures of both frequency-modulation and amplitude-modulation.
Device for frequency modulation of a laser output spectrum

DOEpatents

Beene, James R.; Bemis, Jr., Curtis E.

1986-01-01

A device is provided for fast frequency modulating the output spectrum of multimode lasers and single frequency lasers that are not actively stabilized. A piezoelectric transducer attached to a laser cavity mirror is driven in an unconventional manner to excite resonance vibration of the transducer to rapidly, cyclicly change the laser cavity length. The result is a cyclic sweeping of the output wavelength sufficient to fill the gaps in the laser output frequency spectrum. When such a laser is used to excite atoms or molecules, complete absorption line coverage is made possible.
Device for frequency modulation of a laser output spectrum

DOEpatents

Beene, J.R.; Bemis, C.E. Jr.

1984-07-17

A device is provided for fast frequency modulating the output spectrum of multimode lasers and single frequency lasers that are not actively stabilized. A piezoelectric transducer attached to a laser cavity mirror is driven in an unconventional manner to excite resonance vibration of the tranducer to rapidly, cyclicly change the laser cavity length. The result is a cyclic sweeping of the output wavelength sufficient to fill the gaps in the laser output frequency spectrum. When a laser is used to excite atoms or molecules, complete absorption line coverage is made possible.
KSC-02pd0758

NASA Image and Video Library

2002-05-24

KENNEDY SPACE CENTER, FLA. -- Dressed in a bunny suit, STS-107 Payload Specialist Ilan Ramon, who is with the Israeli Space Agency, reviews data in Columbia's payload bay for Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) experiments for the mission. FREESTAR comprises Mediterranean Israeli Dust, Solar Constant, Shuttle Ozone Limb Sounding, Critical Viscosity of Xenon, Low Power, and Space Experimental Module experiments. Another payload is the SHI Research Double Module (SHI/RDM), also known as SPACEHAB. The experiments range from material sciences to life sciences. STS-107 is scheduled to launch July 11, 2002
Novel, simple and fast automated synthesis of 18F-choline in a single Synthera module

NASA Astrophysics Data System (ADS)

Litman, Y.; Pace, P.; Silva, L.; Hormigo, C.; Caro, R.; Gutierrez, H.; Bastianello, M.; Casale, G.

2012-12-01

The aim of this work is to develop a method to produce 18F-Fluorocholine in a single Synthera module with high yield, quality and reproducibility. We give special importance to the details of the drying and distillation procedures. After 5 syntheses we report a decay corrected yield of (27 ± 2) % (mean ± S.D.). The radiochemical purity was > 95%, and the other quality control parameters were within the specifications. Product 18F-fluorocholine was administrated to 17 humans with no observed side-effects.
Absolute Distance Measurement with the MSTAR Sensor

NASA Technical Reports Server (NTRS)

Lay, Oliver P.; Dubovitsky, Serge; Peters, Robert; Burger, Johan; Ahn, Seh-Won; Steier, William H.; Fetterman, Harrold R.; Chang, Yian

2003-01-01

The MSTAR sensor (Modulation Sideband Technology for Absolute Ranging) is a new system for measuring absolute distance, capable of resolving the integer cycle ambiguity of standard interferometers, and making it possible to measure distance with sub-nanometer accuracy. The sensor uses a single laser in conjunction with fast phase modulators and low frequency detectors. We describe the design of the system - the principle of operation, the metrology source, beamlaunching optics, and signal processing - and show results for target distances up to 1 meter. We then demonstrate how the system can be scaled to kilometer-scale distances.
Application of Gaussian beam ray-equivalent model and back-propagation artificial neural network in laser diode fast axis collimator assembly.

PubMed

Yu, Hao; Rossi, Giammarco; Braglia, Andrea; Perrone, Guido

2016-08-10

The paper presents the development of a tool based on a back-propagation artificial neural network to assist in the accurate positioning of the lenses used to collimate the beam from semiconductor laser diodes along the so-called fast axis. After training using a Gaussian beam ray-equivalent model, the network is capable of indicating the tilt, decenter, and defocus of such lenses from the measured field distribution, so the operator can determine the errors with respect to the actual lens position and optimize the diode assembly procedure. An experimental validation using a typical configuration exploited in multi-emitter diode module assembly and fast axis collimating lenses with different focal lengths and numerical apertures is reported.
A General Surface Representation Module Designed for Geodesy

DTIC Science & Technology

1980-06-01

one considers as a reasonable interpolation function, one of the often accepted compromises is the choice q = 2 (Schumnaker, 1976, Bybee and Bedross...Fast Fourier Transform: Englewood Cliffs, New Jersey. Bybee , J.E. and G.M. Bedross (1978): The IPIN computer network control softward. In: Proceedings
Growth of Acousto-Optic Crystals for Applications in Infrared Region of Spectrum

DTIC Science & Technology

2005-04-30

Acousto - optic (AO) modulators, deflectors, filters offer convenience, reliability, compact size and fast speed in regulation of optical beams. So far...extremely low acousto - optic figure of merit, which automatically results in high requirements on driving electric power and poor diffraction efficiency. It
High Birefringence Liquid Crystals for Laser Hardening and IR Countermeasure

DTIC Science & Technology

2004-09-24

A fast-switching and scattering-free phase modulator using polymer network liquid crystal ( PNLC ) is demonstrated at **=l.55 um for laser beam...steering application. The strong polymer network anchoring greatly reduces the visco-elastic coefficient of the liquid crystal. As a result, the PNLC
OSIRIS Detectors

NASA Astrophysics Data System (ADS)

Joven, E.; Gigante, J.; Beigbeder, F.

OSIRIS (Optical System for Imaging and Low-Resolution Integrated Spectroscopy) is an instrument designed to obtain images and low-resolution spectra of astronomical objects in the optical domain (from 365-1000 nm). It will be installed on Day One (2004) in the Nasmyth focus of the 10-m Spanish GTC Telescope. The mosaic is composed of two abuttable 2Kx4K CCDs to yield a total of 4Kx4K pixels, 15 μm/pixel, 0.1252 plate scale. The arrangement allows the linking of a classical ARC-GenII controller to a PMC frame-grabber, plugged into a VME-CPU card, where a RTOS (VxWorks from Wind River) is running. Some tests and results, carried out with a couple of MAT44-82 engineering grade devices at room temperature, are given.
Integral Fast Reactor fuel pin processor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levinskas, D.

1993-01-01

This report discusses the pin processor which receives metal alloy pins cast from recycled Integral Fast Reactor (IFR) fuel and prepares them for assembly into new IFR fuel elements. Either full length as-cast or precut pins are fed to the machine from a magazine, cut if necessary, and measured for length, weight, diameter and deviation from straightness. Accepted pins are loaded into cladding jackets located in a magazine, while rejects and cutting scraps are separated into trays. The magazines, trays, and the individual modules that perform the different machine functions are assembled and removed using remote manipulators and master-slaves.
Integral Fast Reactor fuel pin processor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levinskas, D.

1993-03-01

This report discusses the pin processor which receives metal alloy pins cast from recycled Integral Fast Reactor (IFR) fuel and prepares them for assembly into new IFR fuel elements. Either full length as-cast or precut pins are fed to the machine from a magazine, cut if necessary, and measured for length, weight, diameter and deviation from straightness. Accepted pins are loaded into cladding jackets located in a magazine, while rejects and cutting scraps are separated into trays. The magazines, trays, and the individual modules that perform the different machine functions are assembled and removed using remote manipulators and master-slaves.
Fast REDOR with CPMG multiple-echo acquisition

NASA Astrophysics Data System (ADS)

Hung, Ivan; Gan, Zhehong

2014-01-01

Rotational-Echo Double Resonance (REDOR) is a widely used experiment for distance measurements in solids. The conventional REDOR experiment measures the signal dephasing from hetero-nuclear recoupling under magic-angle spinning (MAS) in a point by point manner. A modified Carr-Purcell Meiboom-Gill (CPMG) multiple-echo scheme is introduced for fast REDOR measurement. REDOR curves are measured from the CPMG echo amplitude modulation under dipolar recoupling. The real time CPMG-REDOR experiment can speed up the measurement by an order of magnitude. The effects from hetero-nuclear recoupling, the Bloch-Siegert shift and echo truncation to the signal acquisition are discussed and demonstrated.
An advanced communications synthesizer

NASA Astrophysics Data System (ADS)

Scherer, Ernst F.

1994-02-01

With the proliferation of smaller and lower cost EHF terminals, the fast-hopping microwave synthesizer subsystem is rapidly becoming the limiting factor for further size and cost reduction. A new approach, based on a high-speed direct digital synthesizer (DDS) and a very fast voltage controlled oscillator (VCO) tracking loop, has yielded a highly integrable design with true low-cost potential. A frequency range of 1 to 20 GHz can be covered by a simple substitution of the VCO module. This advanced synthesizer realization promises a generic solution to a large class of synthesizer requirements, greatly facilitating standardization and promoting modular system concepts.
Fast response of mechatronics module for robotic

NASA Astrophysics Data System (ADS)

Bukhanov, S. S.; Gryzlov, A. A.; Tsirkunenko, A. T.

2018-05-01

The synthesis technique, the mathematical model and results of experimental investigation of the control system of the robotic complex mechatronic module are presented in the article. It is shown that in most cases the dynamic system can be approximated by the serial connection of two first-order aperiodic links, while the speed in the torque control loop can reach 200-300 rad/s. The specified speed of the system was achieved due to improved specific weight and dimensions parameters of the electric drive (element of the mechatronic system) made on the basis of a contactless motor. The obtained results indicate the possibility of successful application of the proposed mechatronic module for objects of robotized systems in which the reference signal changes at a frequency not exceeding 50 Hz.
Approximate methods for the fast computation of EPR and ST-EPR spectra. V. Application of the perturbation approach to the problem of anisotropic motion

NASA Astrophysics Data System (ADS)

Robinson, B. H.; Dalton, L. R.

1981-01-01

The modulation perturbation treatment of Galloway and Dalton is applied to the solution of the stochastic Liouville equation for the spin density matrix which incorporates an anisotropic rotational diffusion operator. Pseudosecular and saturation terms of the spin hamiltonian are explicitly considered as is the interaction of the electron spins with the applied Zeeman modulation field. The modulation perturbation treatment results in a factor of four improvement in computational speed relative to inversion of the full supermatrix with little or no loss of computational accuracy. The theoretical simulations of EPR and ST-EPR spectra are in nearly quantitative agreement with experimental spectra taken under high resolution conditions.
Computational Re-design of Synthetic Genetic Oscillators for Independent Amplitude and Frequency Modulation.

PubMed

Tomazou, Marios; Barahona, Mauricio; Polizzi, Karen M; Stan, Guy-Bart

2018-04-25

To perform well in biotechnology applications, synthetic genetic oscillators must be engineered to allow independent modulation of amplitude and period. This need is currently unmet. Here, we demonstrate computationally how two classic genetic oscillators, the dual-feedback oscillator and the repressilator, can be re-designed to provide independent control of amplitude and period and improve tunability-that is, a broad dynamic range of periods and amplitudes accessible through the input "dials." Our approach decouples frequency and amplitude modulation by incorporating an orthogonal "sink module" where the key molecular species are channeled for enzymatic degradation. This sink module maintains fast oscillation cycles while alleviating the translational coupling between the oscillator's transcription factors and output. We characterize the behavior of our re-designed oscillators over a broad range of physiologically reasonable parameters, explain why this facilitates broader function and control, and provide general design principles for building synthetic genetic oscillators that are more precisely controllable. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
1995 second modulator-klystron workshop: A modulator-klystron workshop for future linear colliders

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-03-01

This second workshop examined the present state of modulator design and attempted an extrapolation for future electron-positron linear colliders. These colliders are currently viewed as multikilometer-long accelerators consisting of a thousand or more RF sources with 500 to 1,000, or more, pulsed power systems. The workshop opened with two introductory talks that presented the current approaches to designing these linear colliders, the anticipated RF sources, and the design constraints for pulse power. The cost of main AC power is a major economic consideration for a future collider, consequently the workshop investigated efficient modulator designs. Techniques that effectively apply the artmore » of power conversion, from the AC mains to the RF output, and specifically, designs that generate output pulses with very fast rise times as compared to the flattop. There were six sessions that involved one or more presentations based on problems specific to the design and production of thousands of modulator-klystron stations, followed by discussion and debate on the material.« less
Parameters Identification for Photovoltaic Module Based on an Improved Artificial Fish Swarm Algorithm

PubMed Central

Wang, Hong-Hua

2014-01-01

A precise mathematical model plays a pivotal role in the simulation, evaluation, and optimization of photovoltaic (PV) power systems. Different from the traditional linear model, the model of PV module has the features of nonlinearity and multiparameters. Since conventional methods are incapable of identifying the parameters of PV module, an excellent optimization algorithm is required. Artificial fish swarm algorithm (AFSA), originally inspired by the simulation of collective behavior of real fish swarms, is proposed to fast and accurately extract the parameters of PV module. In addition to the regular operation, a mutation operator (MO) is designed to enhance the searching performance of the algorithm. The feasibility of the proposed method is demonstrated by various parameters of PV module under different environmental conditions, and the testing results are compared with other studied methods in terms of final solutions and computational time. The simulation results show that the proposed method is capable of obtaining higher parameters identification precision. PMID:25243233

Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

PubMed

Roepke, T A; Smith, A W; Rønnekleiv, O K; Kelly, M J

2012-06-01

Hypothalamic proopiomelanocortin (POMC) neurons are controlled by many central signals, including serotonin. Serotonin increases POMC activity and reduces feeding behavior via serotonion [5-hydroxytryptamine (5-HT)] receptors by modulating K(+) currents. A potential K(+) current is the M-current, a noninactivating, subthreshold outward K(+) current. Previously, we found that M-current activity was highly reduced in fasted vs. fed states in neuropeptide Y neurons. Because POMC neurons also respond to energy states, we hypothesized that fasting may alter the M-current and/or its modulation by serotonergic input to POMC neurons. Using visualized-patch recording in neurons from fed male enhanced green fluorescent protein-POMC transgenic mice, we established that POMC neurons expressed a robust M-current (102.1 ± 6.7 pA) that was antagonized by the selective KCNQ channel blocker XE-991 (40 μM). However, the XE-991-sensitive current in POMC neurons did not differ between fed and fasted states. To determine if serotonin suppresses the M-current via the 5-HT(2C) receptor, we examined the effects of the 5-HT(2A)/5-HT(2C) receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on the M-current. Indeed, DOI attenuated the M-current by 34.5 ± 6.9% and 42.0 ± 5.3% in POMC neurons from fed and fasted male mice, respectively. In addition, the 5-HT(1B)/5-HT(2C) receptor agonist m-chlorophenylpiperazine attenuated the M-current by 42.4 ± 5.4% in POMC neurons from fed male mice. Moreover, the selective 5-HT(2C) receptor antagonist RS-102221 abrogated the actions of DOI in suppressing the M-current. Collectively, these data suggest that although M-current expression does not differ between fed and fasted states in POMC neurons, serotonin inhibits the M-current via activation of 5-HT(2C) receptors to increase POMC neuronal excitability and, subsequently, reduce food intake.
BeamDyn: a high-fidelity wind turbine blade solver in the FAST modular framework

DOE PAGES

Wang, Qi; Sprague, Michael A.; Jonkman, Jason; ...

2017-03-14

Here, this paper presents a numerical implementation of the geometrically exact beam theory based on the Legendre-spectral-finite-element (LSFE) method. The displacement-based geometrically exact beam theory is presented, and the special treatment of three-dimensional rotation parameters is reviewed. An LSFE is a high-order finite element with nodes located at the Gauss-Legendre-Lobatto points. These elements can be an order of magnitude more computationally efficient than low-order finite elements for a given accuracy level. The new module, BeamDyn, is implemented in the FAST modularization framework for dynamic simulation of highly flexible composite-material wind turbine blades within the FAST aeroelastic engineering model. The frameworkmore » allows for fully interactive simulations of turbine blades in operating conditions. Numerical examples are provided to validate BeamDyn and examine the LSFE performance as well as the coupling algorithm in the FAST modularization framework. BeamDyn can also be used as a stand-alone high-fidelity beam tool.« less
Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia

PubMed Central

Wang, Manqi; Wang, Qian; Whim, Matthew D.

2016-01-01

During fasting, activation of the counter-regulatory response (CRR) prevents hypoglycemia. A major effector arm is the autonomic nervous system that controls epinephrine release from adrenal chromaffin cells and, consequently, hepatic glucose production. However, whether modulation of autonomic function determines the relative strength of the CRR, and thus the ability to withstand food deprivation and maintain euglycemia, is not known. Here we show that fasting leads to altered transmission at the preganglionic → chromaffin cell synapse. The dominant effect is a presynaptic, long-lasting increase in synaptic strength. Using genetic and pharmacological approaches we show this plasticity requires neuropeptide Y, an adrenal cotransmitter and the activation of adrenal Y5 receptors. Loss of neuropeptide Y prevents a fasting-induced increase in epinephrine release and results in hypoglycemia in vivo. These findings connect plasticity within the sympathetic nervous system to a physiological output and indicate the strength of the final synapse in this descending pathway plays a decisive role in maintaining euglycemia. PMID:27092009
BeamDyn: a high-fidelity wind turbine blade solver in the FAST modular framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Qi; Sprague, Michael A.; Jonkman, Jason

Here, this paper presents a numerical implementation of the geometrically exact beam theory based on the Legendre-spectral-finite-element (LSFE) method. The displacement-based geometrically exact beam theory is presented, and the special treatment of three-dimensional rotation parameters is reviewed. An LSFE is a high-order finite element with nodes located at the Gauss-Legendre-Lobatto points. These elements can be an order of magnitude more computationally efficient than low-order finite elements for a given accuracy level. The new module, BeamDyn, is implemented in the FAST modularization framework for dynamic simulation of highly flexible composite-material wind turbine blades within the FAST aeroelastic engineering model. The frameworkmore » allows for fully interactive simulations of turbine blades in operating conditions. Numerical examples are provided to validate BeamDyn and examine the LSFE performance as well as the coupling algorithm in the FAST modularization framework. BeamDyn can also be used as a stand-alone high-fidelity beam tool.« less
Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction

PubMed Central

Shushimita, Shushimita; van der Pol, Pieter; W.F. de Bruin, Ron; N. M. Ijzermans, Jan; van Kooten, Cees; Dor, Frank J. M. F.

2015-01-01

Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these findings, we investigated the effect of short-term DR (30% reduction of total food intake) or three days of water only fasting on MBL in 10–12 weeks old male C57/Bl6 mice. Both dietary regimens significantly reduce the circulating levels of MBL as well as its mRNA expression in liver, the sole production site of MBL. Reconstitution of MBL abolished the protection afforded by dietary restriction, whereas in the fasting group the protection persisted. These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different. PMID:26367533
Fast online Monte Carlo-based IMRT planning for the MRI linear accelerator

NASA Astrophysics Data System (ADS)

Bol, G. H.; Hissoiny, S.; Lagendijk, J. J. W.; Raaymakers, B. W.

2012-03-01

The MRI accelerator, a combination of a 6 MV linear accelerator with a 1.5 T MRI, facilitates continuous patient anatomy updates regarding translations, rotations and deformations of targets and organs at risk. Accounting for these demands high speed, online intensity-modulated radiotherapy (IMRT) re-optimization. In this paper, a fast IMRT optimization system is described which combines a GPU-based Monte Carlo dose calculation engine for online beamlet generation and a fast inverse dose optimization algorithm. Tightly conformal IMRT plans are generated for four phantom cases and two clinical cases (cervix and kidney) in the presence of the magnetic fields of 0 and 1.5 T. We show that for the presented cases the beamlet generation and optimization routines are fast enough for online IMRT planning. Furthermore, there is no influence of the magnetic field on plan quality and complexity, and equal optimization constraints at 0 and 1.5 T lead to almost identical dose distributions.
High Speed Computational Ghost Imaging via Spatial Sweeping

NASA Astrophysics Data System (ADS)

Wang, Yuwang; Liu, Yang; Suo, Jinli; Situ, Guohai; Qiao, Chang; Dai, Qionghai

2017-03-01

Computational ghost imaging (CGI) achieves single-pixel imaging by using a Spatial Light Modulator (SLM) to generate structured illuminations for spatially resolved information encoding. The imaging speed of CGI is limited by the modulation frequency of available SLMs, and sets back its practical applications. This paper proposes to bypass this limitation by trading off SLM’s redundant spatial resolution for multiplication of the modulation frequency. Specifically, a pair of galvanic mirrors sweeping across the high resolution SLM multiply the modulation frequency within the spatial resolution gap between SLM and the final reconstruction. A proof-of-principle setup with two middle end galvanic mirrors achieves ghost imaging as fast as 42 Hz at 80 × 80-pixel resolution, 5 times faster than state-of-the-arts, and holds potential for one magnitude further multiplication by hardware upgrading. Our approach brings a significant improvement in the imaging speed of ghost imaging and pushes ghost imaging towards practical applications.
Gas mixing enhanced by power modulations in atmospheric pressure microwave plasma jet

NASA Astrophysics Data System (ADS)

Voráč, J.; Potočňáková, L.; Synek, P.; Hnilica, J.; Kudrle, V.

2016-04-01

Microwave plasma jet operating in atmospheric pressure argon was power modulated by audio frequency sine envelope in the 102 W power range. Its effluent was imaged using interference filters and ICCD camera for several different phases of the modulating signal. The combination of this fast imaging with spatially resolved optical emission spectroscopy provides useful insights into the plasmachemical processes involved. Phase-resolved schlieren photography was performed to visualize the gas dynamics. The results show that for higher modulation frequencies the plasma chemistry is strongly influenced by formation of transient flow perturbation resembling a vortex during each period. The perturbation formation and speed are strongly influenced by the frequency and power variations while they depend only weakly on the working gas flow rate. From application point of view, the perturbation presence significantly broadened lateral distribution of active species, effectively increasing cross-sectional area suitable for applications.
Voltage equalization of an ultracapacitor module by cell grouping using number partitioning algorithm

NASA Astrophysics Data System (ADS)

Oyarbide, E.; Bernal, C.; Molina, P.; Jiménez, L. A.; Gálvez, R.; Martínez, A.

2016-01-01

Ultracapacitors are low voltage devices and therefore, for practical applications, they need to be used in modules of series-connected cells. Because of the inherent manufacturing tolerance of the capacitance parameter of each cell, and as the maximum voltage value cannot be exceeded, the module requires inter-cell voltage equalization. If the intended application suffers repeated fast charging/discharging cycles, active equalization circuits must be rated to full power, and thus the module becomes expensive. Previous work shows that a series connection of several sets of paralleled ultracapacitors minimizes the dispersion of equivalent capacitance values, and also the voltage differences between capacitors. Thus the overall life expectancy is improved. This paper proposes a method to distribute ultracapacitors with a number partitioning-based strategy to reduce the dispersion between equivalent submodule capacitances. Thereafter, the total amount of stored energy and/or the life expectancy of the device can be considerably improved.
A laser based frequency modulated NL-OSL phenomenon

NASA Astrophysics Data System (ADS)

Mishra, D. R.; Bishnoi, A. S.; Soni, Anuj; Rawat, N. S.; Bhatt, B. C.; Kulkarni, M. S.; Babu, D. A. R.

2015-01-01

The detailed theoretical and experimental approach to novel technique of pulse frequency modulated stimulation (PFMS) method has been described for NL-OSL phenomenon. This method involved pulsed frequency modulation with respect to time for fixed pulse width of 532 nm continuous wave (CW)-laser light. The linearly modulated (LM)-, non-linearly (NL)-stimulation profiles have been generated using fast electromagnetic optical shutter. The PFMS parameters have been determined for present experimental setup. The PFMS based LM-, NL-OSL studies have been carried out on dosimetry grade single crystal α-Al2O3:C. The photo ionization cross section of α-Al2O3:C has been found to be ∼9.97 × 10-19 cm2 for 532 nm laser light using PFMS LM-OSL studies under assumption of first order of kinetic. This method of PFMS is found to be a potential alternative to generate different stimulation profiles using CW-light sources.
The microstructure of starchy food modulates its digestibility.

PubMed

Tian, Jinhu; Ogawa, Yukiharu; Shi, John; Chen, Shiguo; Zhang, Huiling; Liu, Donghong; Ye, Xingqian

2018-06-05

Starch is the main carbohydrate in human nutrition and shows a range of desired food properties. It has been demonstrated that fast digestion of starchy food can induce many health issues (e.g., hyperglycaemia, diabetes, etc.); therefore, how to modulate its digestion is an interesting topic. Previous studies have revealed that the microstructure and digestibility of starchy food of different botanical origin or from multiple processes are quite different; modulating starch digestion by retaining or altering its microstructure may be effective. In the present review, the current knowledge of the relationship between microstructural changes to starchy food and its digestibility at molecular, cell and tissue, and food processing levels is summarized. New technologies focused on microstructure studies and ways to manipulate food microstructure to modulate starch digestibility are also reviewed. In particular, some insights focusing on the future study of microstructure and the digestibility of starchy food are also suggested.
Electro-optical modulator in a polymerinfiltrated silicon slotted photonic crystal waveguide heterostructure resonator.

PubMed

Wülbern, Jan Hendrik; Petrov, Alexander; Eich, Manfred

2009-01-05

We present a novel concept of a compact, ultra fast electro-optic modulator, based on photonic crystal resonator structures that can be realized in two dimensional photonic crystal slabs of silicon as core material employing a nonlinear optical polymer as infiltration and cladding material. The novel concept is to combine a photonic crystal heterostructure cavity with a slotted defect waveguide. The photonic crystal lattice can be used as a distributed electrode for the application of a modulation signal. An electrical contact is hence provided while the optical wave is kept isolated from the lossy metal electrodes. Thereby, well known disadvantages of segmented electrode designs such as excessive scattering are avoided. The optical field enhancement in the slotted region increases the nonlinear interaction with an external electric field resulting in an envisaged switching voltage of approximately 1 V at modulation speeds up to 100 GHz.
Current inversion in the Lévy ratchet.

PubMed

Dybiec, Bartłomiej

2008-12-01

We study the motion of an overdamped test particle in a static periodic potential lacking spatial symmetry under the influence of periodically modulated alpha -stable (Lévy) type noise. Due to the nonthermal character of the driving noise, the particle exhibits a motion with a preferred direction. The additional periodic modulation of the noise asymmetry changes the behavior of the static "Lévy ratchet." For the fast rate of the noise asymmetry modulation, the Lévy ratchet behaves like the one driven by the symmetric alpha -stable noise. When the modulation period is larger, the nontrivial effects of the noise asymmetry on the behavior of the Lévy ratchet are visible. In particular, the current inversion is observed in the system at hand. The properties of the Lévy ratchet are studied by use of the robust measures of directionality, which are defined regardless of the type of the stochastic driving.
Fast and Forceful: Modulation of Response Activation Induced by Shifts of Perceived Depth in Virtual 3D Space

PubMed Central

Plewan, Thorsten; Rinkenauer, Gerhard

2016-01-01

Reaction time (RT) can strongly be influenced by a number of stimulus properties. For instance, there was converging evidence that perceived size rather than physical (i.e., retinal) size constitutes a major determinant of RT. However, this view has recently been challenged since within a virtual three-dimensional (3D) environment retinal size modulation failed to influence RT. In order to further investigate this issue in the present experiments response force (RF) was recorded as a supplemental measure of response activation in simple reaction tasks. In two separate experiments participants’ task was to react as fast as possible to the occurrence of a target located close to the observer or farther away while the offset between target locations was increased from Experiment 1 to Experiment 2. At the same time perceived target size (by varying the retinal size across depth planes) and target type (sphere vs. soccer ball) were modulated. Both experiments revealed faster and more forceful reactions when targets were presented closer to the observers. Perceived size and target type barely affected RT and RF in Experiment 1 but differentially affected both variables in Experiment 2. Thus, the present findings emphasize the usefulness of RF as a supplement to conventional RT measurement. On a behavioral level the results confirm that (at least) within virtual 3D space perceived object size neither strongly influences RT nor RF. Rather the relative position within egocentric (body-centered) space presumably indicates an object’s behavioral relevance and consequently constitutes an important modulator of visual processing. PMID:28018273
Focusing light inside dynamic scattering media with millisecond digital optical phase conjugation (Conference Presentation)

NASA Astrophysics Data System (ADS)

Liu, Yan; Ma, Cheng; Shen, Yuecheng; Wang, Lihong V.

2017-02-01

Optical phase conjugation based wavefront shaping techniques are being actively developed to focus light through or inside scattering media such as biological tissue, and they promise to revolutionize optical imaging, manipulation, and therapy. The speed of digital optical phase conjugation (DOPC) has been limited by the low speeds of cameras and spatial light modulators (SLMs), preventing DOPC from being applied to thick living tissue. Recently, a fast DOPC system was developed based on a single-shot wavefront measurement method, a field programmable gate array (FPGA) for data processing, and a digital micromirror device (DMD) for fast modulation. However, this system has the following limitations. First, the reported single-shot wavefront measurement method does not work when our goal is to focus light inside, instead of through, scattering media. Second, the DMD performed binary amplitude modulation, which resulted in a lower focusing contrast compared with that of phase modulations. Third, the optical fluence threshold causing DMDs to malfunction under pulsed laser illumination is lower than that of liquid crystal based SLMs, and the system alignment is significantly complicated by the oblique reflection angle of the DMD. Here, we developed a simple but high-speed DOPC system using a ferroelectric liquid crystal based SLM (512 × 512 pixels), and focused light through three diffusers within 4.7 ms. Using focused-ultrasound-guided DOPC along with a double exposure scheme, we focused light inside a scattering medium containing two diffusers within 7.7 ms, thus achieving the fastest digital time-reversed ultrasonically encoded (TRUE) optical focusing to date.
Intermittent fasting during winter and spring affects body composition and reproduction of a migratory duck

USGS Publications Warehouse

Barboza, P.S.; Jorde, Dennis G.

2002-01-01

We compared food intake, body mass and body composition of male and female black ducks (Anas rubripes) during winter (January-March). Birds were fed the same complete diet ad libitum on consecutive days each week without fasting (control; nine male; nine female) or with either short fasts (2 day.week-1; nine male; nine female), or long fasts (4 day.week-1; eleven male; twelve female). We continued treatments through spring (March-May) to measure the effect of intermittent fasts on body mass and egg production. Daily food intake of fasted birds was up to four times that of unfasted birds. Weekly food intake of males was similar among treatments (364 g.kg-1.week-1) but fasted females consumed more than unfasted females in January (363 g.kg-1.week-1 vs. 225 g.kg-1.week-1). Although both sexes lost 10-14% body mass, fasted females lost less mass and lipid than unfasted females during winter. Total body nitrogen was conserved over winter in both sexes even though the heart and spleen lost mass while the reproductive tract and liver gained mass. Intermittent fasting increased liver, intestinal tissue and digesta mass of females but not of males. Fasting delayed egg production in spring but did not affect size, fertility or hatching of the clutch. Females on long fasts were still heavier than controls after laying eggs. Thus black ducks combine flexibility of food intake with plasticity of digestive tract, liver and adipose tissue when food supply is interrupted during winter. Females modulate body mass for survival and defer reproduction when food supply is interrupted in spring.
Arousal-state modulation in children with AD/HD.

PubMed

Benikos, Nicholas; Johnstone, Stuart J

2009-01-01

To investigate the effect of arousal-state modulation, via manipulation of stimulus event-rate, on response inhibition in children with Attention-Deficit/Hyperactivity disorder (AD/HD) using behavioural and ERP measures. Eighteen children with AD/HD, aged 7-14years, and 18 age-and sex-matched controls performed a cued visual Go/Nogo task (70% Go) with stimuli presented at fast, medium and slow event-rates. Task performance and ERPs to Warning, Go and Nogo stimuli, as well as preparation between the S1-S2 interval, were examined for group differences. AD/HD subjects displayed poorer response inhibition during the fast condition, accompanied by a reduced Nogo P3. Group differences during the fast rate extended to Warning cues, with the AD/HD group showing ERP evidence of atypical orienting/preparation, as indexed by the early and late CNV, and early sensory/attentive processing prior to S2. Although deficient response inhibition has been proposed as the core deficit in AD/HD, the results of the present study highlight the key role of energetic factors. Furthermore, group differences found to cues suggest that this effect extends to the processing of task-irrelevant stimuli. This was the first ERP Go/Nogo task investigation using three event-rates, and the results support the theory that state factors may contribute to response inhibition deficits in AD/HD.
Modulation format identification aided hitless flexible coherent transceiver.

PubMed

Xiang, Meng; Zhuge, Qunbi; Qiu, Meng; Zhou, Xingyu; Zhang, Fangyuan; Tang, Ming; Liu, Deming; Fu, Songnian; Plant, David V

2016-07-11

We propose a hitless flexible coherent transceiver enabled by a novel modulation format identification (MFI) scheme for dynamic agile optical networks. The modulation format transparent digital signal processing (DSP) is realized by a block-wise decision-directed least-mean-square (DD-LMS) equalizer for channel tracking, and a pilot symbol aided superscalar phase locked loop (PLL) for carrier phase estimation (CPE). For the MFI, the modulation format information is encoded onto the pilot symbols initially used for CPE. Therefore, the proposed MFI method does not require extra overhead. Moreover, it can identify arbitrary modulation formats including multi-dimensional formats, and it enables tracking of the format change for short data blocks. The performance of the proposed hitless flexible coherent transceiver is successfully evaluated with five modulation formats including QPSK, 16QAM, 64QAM, Hybrid QPSK/8QAM and set-partitioning (SP)-512-QAM. We show that the proposed MFI method induces a negligible performance penalty. Moreover, we experimentally demonstrate that such a hitless transceiver can adapt to fast block-by-block modulation format switching. Finally, the performance improvement of the proposed MFI method is experimentally verified with respect to other commonly used MFI methods.
Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations.

PubMed

Belkacemi, Louiza; Selselet-Attou, Ghalem; Bulur, Nurdan; Louchami, Karim; Sener, Abdullah; Malaisse, Willy J

2011-01-01

The present report concerns several post-mortem variables examined in sand rats that were either maintained on a vegetal diet (control animals) or exposed first during a 20-day transition period to a mixed diet consisting of a fixed amount of a hypercaloric food and decreasing amounts of the vegetal food and then to a 30-day experimental period of exposure to the hypercaloric food. During the latter period, all animals were either given free access to food or fasting daily for 15 h, i.e. from 5.00 p.m. to 8.00 a.m. The body weight, liver wet weight, pancreas wet weight, plasma glucose and haemoglobin A1c concentration, plasma insulin concentration, insulinogenic index, insulin resistance HOMA, plasma cholesterol and triglyceride concentration, liver triglyceride and phospholipid content were all measured. Pancreatic islet (insulin, GLUT2) and liver (lipid droplets) histology were also examined. The main findings consisted in a lower body weight of fasting than non-fasting animals, a higher liver weight in non-diabetic and diabetic rats than in control non-fasting (but not so in fasting) animals, a decrease of pancreas weight in non-diabetic and diabetic as distinct from control animals, a fasting-induced decrease in plasma glucose, plasma insulin and insulin resistance HOMA, plasma cholesterol and triglyceride concentration and triglyceride liver content.
PCB disruption of the hypothalamus-pituitary-interrenal axis involves brain glucocorticoid receptor downregulation in anadromous Arctic charr

USGS Publications Warehouse

Aluru, N.; Jorgensen, E.H.; Maule, A.G.; Vijayan, M.M.

2004-01-01

We examined whether brain glucocorticoid receptor (GR) modulation by polychlorinated biphenyls (PCBs) was involved in the abnormal cortisol response to stress seen in anadromous Arctic charr (Salvelinus alpinus). Fish treated with Aroclor 1254 (0, 1, 10, and 100 mg/kg body mass) were maintained for 5 mo without feeding in the winter to mimic their seasonal fasting cycle, whereas a fed group with 0 and 100 mg/kg Aroclor was maintained for comparison. Fasting elevated plasma cortisol levels and brain GR content but depressed heat shock protein 90 (hsp90) and interrenal cortisol production capacity. Exposure of fasted fish to Aroclor 1254 resulted in a dose-dependent increase in brain total PCB content. This accumulation in fish with high PCB dose was threefold higher in fasted fish compared with fed fish. PCBs depressed plasma cortisol levels but did not affect in vitro interrenal cortisol production capacity in fasted charr. At high PCB dose, the brain GR content was significantly lower in the fasted fish and this corresponded with a lower brain hsp70 and hsp90 content. The elevation of plasma cortisol levels and upregulation of brain GR content may be an important adaptation to extended fasting in anadromous Arctic charr, and this response was disrupted by PCBs. Taken together, the hypothalamus-pituitary- interrenal axis is a target for PCB impact during winter emaciation in anadromous Arctic charr.

S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.

PubMed

Groome, James R; Winston, Vern

2013-05-01

The movement of positively charged S4 segments through the electric field drives the voltage-dependent gating of ion channels. Studies of prokaryotic sodium channels provide a mechanistic view of activation facilitated by electrostatic interactions of negatively charged residues in S1 and S2 segments, with positive counterparts in the S4 segment. In mammalian sodium channels, S4 segments promote domain-specific functions that include activation and several forms of inactivation. We tested the idea that S1-S3 countercharges regulate eukaryotic sodium channel functions, including fast inactivation. Using structural data provided by bacterial channels, we constructed homology models of the S1-S4 voltage sensor module (VSM) for each domain of the mammalian skeletal muscle sodium channel hNaV1.4. These show that side chains of putative countercharges in hNaV1.4 are oriented toward the positive charge complement of S4. We used mutagenesis to define the roles of conserved residues in the extracellular negative charge cluster (ENC), hydrophobic charge region (HCR), and intracellular negative charge cluster (INC). Activation was inhibited with charge-reversing VSM mutations in domains I-III. Charge reversal of ENC residues in domains III (E1051R, D1069K) and IV (E1373K, N1389K) destabilized fast inactivation by decreasing its probability, slowing entry, and accelerating recovery. Several INC mutations increased inactivation from closed states and slowed recovery. Our results extend the functional characterization of VSM countercharges to fast inactivation, and support the premise that these residues play a critical role in domain-specific gating transitions for a mammalian sodium channel.
The impact of obesity, sex, and diet on hepatic glucose production in cats.

PubMed

Kley, Saskia; Hoenig, Margarethe; Glushka, John; Jin, Eunsook S; Burgess, Shawn C; Waldron, Mark; Jordan, Erin T; Prestegard, James H; Ferguson, Duncan C; Wu, Shaoxiong; Olson, Darin E

2009-04-01

Obesity is a risk factor for type 2 diabetes in cats. The risk of developing diabetes is severalfold greater for male cats than for females, even after having been neutered early in life. The purpose of this study was to investigate the role of different metabolic pathways in the regulation of endogenous glucose production (EGP) during the fasted state considering these risk factors. A triple tracer protocol using (2)H(2)O, [U-(13)C(3)]propionate, and [3,4-(13)C(2)]glucose was applied in overnight-fasted cats (12 lean and 12 obese; equal sex distribution) fed three different diets. Compared with lean cats, obese cats had higher insulin (P < 0.001) but similar blood glucose concentrations. EGP was lower in obese cats (P < 0.001) due to lower glycogenolysis and gluconeogenesis (GNG; P < 0.03). Insulin, body mass index, and girth correlated negatively with EGP (P < 0.003). Female obese cats had approximately 1.5 times higher fluxes through phosphoenolpyruvate carboxykinase (P < 0.02) and citrate synthase (P < 0.05) than male obese cats. However, GNG was not higher because pyruvate cycling was increased 1.5-fold (P < 0.03). These results support the notion that fasted obese cats have lower hepatic EGP compared with lean cats and are still capable of maintaining fasting euglycemia, despite the well-documented existence of peripheral insulin resistance in obese cats. Our data further suggest that sex-related differences exist in the regulation of hepatic glucose metabolism in obese cats, suggesting that pyruvate cycling acts as a controlling mechanism to modulate EGP. Increased pyruvate cycling could therefore be an important factor in modulating the diabetes risk in female cats.
Variation across individuals and items determine learning outcomes from fast mapping.

PubMed

Coutanche, Marc N; Koch, Griffin E

2017-11-01

An approach to learning words known as "fast mapping" has been linked to unique neurobiological and behavioral markers in adult humans, including rapid lexical integration. However, the mechanisms supporting fast mapping are still not known. In this study, we sought to help change this by examining factors that modulate learning outcomes. In 90 subjects, we systematically manipulated the typicality of the items used to support fast mapping (foils), and quantified learners' inclination to employ semantic, episodic, and spatial memory through the Survey of Autobiographical Memory (SAM). We asked how these factors affect lexical competition and recognition performance, and then asked how foil typicality and lexical competition are related in an independent dataset. We find that both the typicality of fast mapping foils, and individual differences in how different memory systems are employed, influence lexical competition effects after fast mapping, but not after other learning approaches. Specifically, learning a word through fast mapping with an atypical foil led to lexical competition, while a typical foil led to lexical facilitation. This effect was particularly evident in individuals with a strong tendency to employ semantic memory. We further replicated the relationship between continuous foil atypicality and lexical competition in an independent dataset. These findings suggest that semantic properties of the foils that support fast mapping can influence the degree and nature of subsequent lexical integration. Further, the effects of foils differ based on an individual's tendency to draw-on the semantic memory system. Copyright © 2017 Elsevier Ltd. All rights reserved.
Ultra-fast HPM detectors improve NAD(P)H FLIM

NASA Astrophysics Data System (ADS)

Becker, Wolfgang; Wetzker, Cornelia; Benda, Aleš

2018-02-01

Metabolic imaging by NAD(P)H FLIM requires the decay functions in the individual pixels to be resolved into the decay components of bound and unbound NAD(P)H. Metabolic information is contained in the lifetime and relative amplitudes of the components. The separation of the decay components and the accuracy of the amplitudes and lifetimes improves substantially by using ultra-fast HPM-100-06 and HPM-100-07 hybrid detectors. The IRF width in combination with the Becker & Hickl SPC-150N and SPC-150NX TCSPC modules is less than 20 ps. An IRF this fast does not interfere with the fluorescence decay. The usual deconvolution process in the data analysis then virtually becomes a simple curve fitting, and the parameters of the NAD(P)H decay components are obtained at unprecedented accuracy.
Engineering the mobility increment in pentacene-based field-effect transistors by fast cooling of polymeric modification layer

NASA Astrophysics Data System (ADS)

Ling, Haifeng; Zhang, Chenxi; Chen, Yan; Shao, Yaqing; Li, Wen; Li, Huanqun; Chen, Xudong; Yi, Mingdong; Xie, Linghai; Huang, Wei

2017-06-01

In this work, we investigate the effect of the cooling rate of polymeric modification layers (PMLs) on the mobility improvement of pentacene-based organic field-effect transistors (OFETs). In contrast to slow cooling (SC), the OFETs fabricated through fast cooling (FC) with PMLs containing side chain-phenyl rings, such as polystyrene (PS) and poly (4-vinylphenol) (PVP), show an obvious mobility incensement compared with that of π-group free polymethylmethacrylate (PMMA). Atomic force microscopy (AFM) images and x-ray diffraction (XRD) characterizations have showed that fast-cooled PMLs could effectively enhance the crystallinity of pentacene, which might be related to the optimized homogeneity of surface energy on the surface of polymeric dielectrics. Our work has demonstrated that FC treatment could be a potential strategy for performance modulation of OFETs.
Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations.

PubMed

Belkacemi, Louiza; Selselet-Attou, Ghalem; Louchami, Karim; Sener, Abdullah; Malaisse, Willy J

2010-11-01

This study deals with the effects of daily intermittent fasting for 15 h upon the development of diabetes in sand rats exposed to a hypercaloric diet. The same pattern of daily intermittent fasting was imposed on sand rats maintained on a purely vegetal diet (control animals). Over the last 30 days of the present experiments, non-fasting animals gained weight, whilst intermittently fasting sand rats lost weight. In this respect, there was no significant difference between control animals and either diabetic or non-diabetic sand rats exposed to the hypercaloric diet. The postprandial glycemia remained fairly stable in the control animals. During a 3-week transition period from a purely vegetal to a hypercaloric diet, the post-prandial glycemia increased by 5.95 ± 1.26 mM (n=6) in diabetic sand rats, as distinct from an increase of only 0.45 ± 0.56 mM (n=6) in the non-diabetic animals. During the intermittent fasting period, the postprandial glycemia decreased significantly in the diabetic animals, but not so in the non-diabetic sand rats. Before the switch in food intake, the peak glycemia at the 30th min of an intraperitoneal glucose tolerance test was already higher in the diabetic than non-diabetic rats. In both the non-diabetic and diabetic sand rats, intermittent fasting prevented the progressive deterioration of glucose tolerance otherwise observed in non-fasting animals. These findings reveal that, at least in sand rats, intermittent daily fasting prevents the progressive deterioration of glucose tolerance otherwise taking place when these animals are exposed to a hypercaloric diet.
fastBMA: scalable network inference and transitive reduction.

PubMed

Hung, Ling-Hong; Shi, Kaiyuan; Wu, Migao; Young, William Chad; Raftery, Adrian E; Yeung, Ka Yee

2017-10-01

Inferring genetic networks from genome-wide expression data is extremely demanding computationally. We have developed fastBMA, a distributed, parallel, and scalable implementation of Bayesian model averaging (BMA) for this purpose. fastBMA also includes a computationally efficient module for eliminating redundant indirect edges in the network by mapping the transitive reduction to an easily solved shortest-path problem. We evaluated the performance of fastBMA on synthetic data and experimental genome-wide time series yeast and human datasets. When using a single CPU core, fastBMA is up to 100 times faster than the next fastest method, LASSO, with increased accuracy. It is a memory-efficient, parallel, and distributed application that scales to human genome-wide expression data. A 10 000-gene regulation network can be obtained in a matter of hours using a 32-core cloud cluster (2 nodes of 16 cores). fastBMA is a significant improvement over its predecessor ScanBMA. It is more accurate and orders of magnitude faster than other fast network inference methods such as the 1 based on LASSO. The improved scalability allows it to calculate networks from genome scale data in a reasonable time frame. The transitive reduction method can improve accuracy in denser networks. fastBMA is available as code (M.I.T. license) from GitHub (https://github.com/lhhunghimself/fastBMA), as part of the updated networkBMA Bioconductor package (https://www.bioconductor.org/packages/release/bioc/html/networkBMA.html) and as ready-to-deploy Docker images (https://hub.docker.com/r/biodepot/fastbma/). © The Authors 2017. Published by Oxford University Press.
Adenosine transiently modulates stimulated dopamine release in the caudate putamen via A1 receptors

PubMed Central

Ross, Ashley E.; Venton, B. Jill

2014-01-01

Adenosine modulates dopamine in the brain via A1 and A2A receptors, but that modulation has only been characterized on a slow time scale. Recent studies have characterized a rapid signaling mode of adenosine that suggests a possible rapid modulatory role. Here, fast-scan cyclic voltammetry was used to characterize the extent to which transient adenosine changes modulate stimulated dopamine release (5 pulses at 60 Hz) in rat caudate putamen brain slices. Exogenous adenosine was applied and dopamine concentration monitored. Adenosine only modulated dopamine when it was applied 2 or 5 s before stimulation. Longer time intervals and bath application of 5 µM adenosine did not decrease dopamine release. Mechanical stimulation of endogenous adenosine 2s before dopamine stimulation also decreased stimulated dopamine release by 41 ± 7 %, similar to the 54 ± 6 % decrease in dopamine after exogenous adenosine application. Dopamine inhibition by transient adenosine was recovered within 10 minutes. The A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) blocked the dopamine modulation, whereas dopamine modulation was unaffected by the A2A receptor antagonist SCH 442416. Thus, transient adenosine changes can transiently modulate phasic dopamine release via A1 receptors. These data demonstrate that adenosine has a rapid, but transient, modulatory role in the brain. PMID:25219576
Recent advances in IR liquid crystal spatial light modulators

NASA Astrophysics Data System (ADS)

Peng, Fenglin; Twieg, Robert J.; Wu, Shin-Tson

2015-09-01

Liquid crystal (LC) is an amazing class of electro-optic media; its applications span from visible to infrared, millimeter wave, and terahertz regions. In the visible and short-wavelength infrared (SWIR) regions, most LCs are highly transparent. However, to extend the electro-optic application of LCs into MWIR and LWIR, several key technical challenges have to be overcome: (1) low absorption loss, (2) high birefringence, (3) low operation voltage, and (4) fast response time. In the MWIR and LWIR regions, several fundamental molecular vibration bands and overtones exist, which contribute to high absorption loss. The absorbed light turns to heat and then alters the birefringence locally, which in turns causes spatially non-uniform phase modulation. To suppress the optical loss, several approaches have been investigated: (1) Employing thin cell gap by choosing a high birefringence LC mixture; (2) Shifting the absorption bands outside the spectral region of interest by deuteration, fluorination, or chlorination; (3) Reducing the overtone absorption by using a short alkyl chain. In this paper, we report some recently developed chlorinated LC compounds and mixtures with low absorption loss in the SWIR and MWIR regions. To achieve fast response time, we demonstrated a polymer network liquid crystal with 2π phase change at MWIR and response time less than 5 ms. Approaches to extend such a liquid crystal spatial light modulator to long-wavelength infrared will be discussed.
Overview of diagnostic performance and results for the first operation phase in Wendelstein 7-X (invited)

DOE PAGES

Krychowiak, M.

2016-10-27

Wendelstein 7-X, a superconducting optimized stellarator built in Greifswald/Germany, started its first plasmas with the last closed flux surface (LCFS) defined by 5 uncooled graphite limiters in December 2015. At the end of the 10 weeks long experimental campaign (OP1.1) more than 20 independent diagnostic systems were in operation, allowing detailed studies of many interesting plasma phenomena. For example, fast neutral gas manometers supported by video cameras (including one fast-frame camera with frame rates of tens of kHz) as well as visible cameras with different interference filters, with field of views covering all ten half-modules of the stellarator, discovered amore » MARFE-like radiation zone on the inboard side of machine module 4. This structure is presumably triggered by an inadvertent plasma-wall interaction in module 4 resulting in a high impurity influx that terminates some discharges by radiation cooling. The main plasma parameters achieved in OP1.1 exceeded predicted values in discharges of a length reaching 6 s. Although OP1.1 is characterized by short pulses, many of the diagnostics are already designed for quasi-steady state operation of 30 min discharges heated at 10 MW of ECRH. Finally, an overview of diagnostic performance for OP1.1 is given, including some highlights from the physics campaigns.« less
Ways to suppress click and pop for class D amplifiers

NASA Astrophysics Data System (ADS)

Haishi, Wang; Bo, Zhang; Jiang, Sun

2012-08-01

Undesirable audio click and pop may be generated in a speaker or headphone. Compared to linear (class A/B/AB) amplifiers, class D amplifiers that comprise of an input stage and a modulation stage are more prone to producing click and pop. This article analyzes sources that generate click and pop in class D amplifiers, and corresponding ways to suppress them. For a class D amplifier with a single-ended input, click and pop is likely to be due to two factors. One is from a voltage difference (VDIF) between the voltage of an input capacitance (VCIN) and a reference voltage (VREF) of the input stage, and the other one is from the non-linear switching during the setting up of the bias and feedback voltages/currents (BFVC) of the modulation stage. In this article, a fast charging loop is introduced into the input stage to charge VCIN to roughly near VREF. Then a correction loop further charges or discharges VCIN, substantially equalizing it with VREF. Dummy switches are introduced into the modulation stage to provide switching signals for setting up BFVC, and the power switches are disabled until the BFVC are set up successfully. A two channel single-ended class D amplifier with the above features is fabricated with 0.5 μm Bi-CMOS process. Road test and fast Fourier transform analysis indicate that there is no noticeable click and pop.
Overview of diagnostic performance and results for the first operation phase in Wendelstein 7-X (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krychowiak, M.

Wendelstein 7-X, a superconducting optimized stellarator built in Greifswald/Germany, started its first plasmas with the last closed flux surface (LCFS) defined by 5 uncooled graphite limiters in December 2015. At the end of the 10 weeks long experimental campaign (OP1.1) more than 20 independent diagnostic systems were in operation, allowing detailed studies of many interesting plasma phenomena. For example, fast neutral gas manometers supported by video cameras (including one fast-frame camera with frame rates of tens of kHz) as well as visible cameras with different interference filters, with field of views covering all ten half-modules of the stellarator, discovered amore » MARFE-like radiation zone on the inboard side of machine module 4. This structure is presumably triggered by an inadvertent plasma-wall interaction in module 4 resulting in a high impurity influx that terminates some discharges by radiation cooling. The main plasma parameters achieved in OP1.1 exceeded predicted values in discharges of a length reaching 6 s. Although OP1.1 is characterized by short pulses, many of the diagnostics are already designed for quasi-steady state operation of 30 min discharges heated at 10 MW of ECRH. Finally, an overview of diagnostic performance for OP1.1 is given, including some highlights from the physics campaigns.« less
Fast and robust segmentation of white blood cell images by self-supervised learning.

PubMed

Zheng, Xin; Wang, Yong; Wang, Guoyou; Liu, Jianguo

2018-04-01

A fast and accurate white blood cell (WBC) segmentation remains a challenging task, as different WBCs vary significantly in color and shape due to cell type differences, staining technique variations and the adhesion between the WBC and red blood cells. In this paper, a self-supervised learning approach, consisting of unsupervised initial segmentation and supervised segmentation refinement, is presented. The first module extracts the overall foreground region from the cell image by K-means clustering, and then generates a coarse WBC region by touching-cell splitting based on concavity analysis. The second module further uses the coarse segmentation result of the first module as automatic labels to actively train a support vector machine (SVM) classifier. Then, the trained SVM classifier is further used to classify each pixel of the image and achieve a more accurate segmentation result. To improve its segmentation accuracy, median color features representing the topological structure and a new weak edge enhancement operator (WEEO) handling fuzzy boundary are introduced. To further reduce its time cost, an efficient cluster sampling strategy is also proposed. We tested the proposed approach with two blood cell image datasets obtained under various imaging and staining conditions. The experiment results show that our approach has a superior performance of accuracy and time cost on both datasets. Copyright © 2018 Elsevier Ltd. All rights reserved.
Affective and contextual values modulate spatial frequency use in object recognition

PubMed Central

Caplette, Laurent; West, Gregory; Gomot, Marie; Gosselin, Frédéric; Wicker, Bruno

2014-01-01

Visual object recognition is of fundamental importance in our everyday interaction with the environment. Recent models of visual perception emphasize the role of top-down predictions facilitating object recognition via initial guesses that limit the number of object representations that need to be considered. Several results suggest that this rapid and efficient object processing relies on the early extraction and processing of low spatial frequencies (LSF). The present study aimed to investigate the SF content of visual object representations and its modulation by contextual and affective values of the perceived object during a picture-name verification task. Stimuli consisted of pictures of objects equalized in SF content and categorized as having low or high affective and contextual values. To access the SF content of stored visual representations of objects, SFs of each image were then randomly sampled on a trial-by-trial basis. Results reveal that intermediate SFs between 14 and 24 cycles per object (2.3–4 cycles per degree) are correlated with fast and accurate identification for all categories of objects. Moreover, there was a significant interaction between affective and contextual values over the SFs correlating with fast recognition. These results suggest that affective and contextual values of a visual object modulate the SF content of its internal representation, thus highlighting the flexibility of the visual recognition system. PMID:24904514
Performance Characterization of Obstacle Detection Algorithms for Aircraft Navigation

NASA Technical Reports Server (NTRS)

Kasturi, Rangachar; Camps, Octavia; Coraor, Lee; Gandhi, Tarak; Hartman, Kerry; Yang, Mau-Tsuen

2000-01-01

The research reported here is a part of NASA's Synthetic Vision System (SVS) project for the development of a High Speed Civil Transport Aircraft (HSCT). One of the components of the SVS is a module for detection of potential obstacles in the aircraft's flight path by analyzing the images captured by an on-board camera in real-time. Design of such a module includes the selection and characterization of robust, reliable, and fast techniques and their implementation for execution in real-time. This report describes the results of our research in realizing such a design.
FAST TRACK COMMUNICATION: An electromagnetically induced grating by microwave modulation

NASA Astrophysics Data System (ADS)

Xiao, Zhi-Hong; Shin, Sung Guk; Kim, Kisik

2010-08-01

We study the phenomenon of an electromagnetically induced phase grating in a double-dark state system of 87Rb atoms, the two closely placed lower fold levels of which are coupled by a weak microwave field. Owing to the existence of the weak microwave field, the efficiency of the phase grating is strikingly improved, and an efficiency of approximately 33% can be achieved. Under the action of the weak standing wave field, the high efficiency of the phase grating can be maintained by modulating the strength and detuning of the weak microwave field, increasing the strength of the standing wave field.
Field alignment of bent-core smectic liquid crystals for analog optical phase modulation

NASA Astrophysics Data System (ADS)

Shen, Y.; Goodhew, L.; Shao, R.; Moran, M.; Korblova, E.; Walba, D. M.; Clark, N. A.; Maclennan, J. E.; Rudquist, P.

2015-05-01

A general method for aligning bent-core smectic liquid crystal materials is described. Alternating electric fields between interdigitated electrodes patterned on one cell surface create torques on the liquid crystal that result in uniform "bookshelf" orientation of the smectic layers. The aligned cell can then be driven in the conventional way by applying an electric field between all of the stripe electrodes connected together and a monolithic electrode on the other cell surface. Fast, analog, optical phase-only modulation is demonstrated in a device containing a polar, bent-core SmAPF material aligned using this technique.
Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors

PubMed Central

Pankratov, Yuriy

2017-01-01

Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia. Recent data show that postsynaptic P2X receptors underlie slow neuromodulatory actions rather than fast synaptic transmission at brain synapses. Here, we review these findings with a particular focus on the release of ATP by astrocytes and the diversity of postsynaptic P2X-mediated modulation of synaptic strength and plasticity in the CNS. PMID:28845311
The VLSI design of the sub-band filterbank in MP3 decoding

NASA Astrophysics Data System (ADS)

Liu, Jia-Xin; Luo, Li

2018-03-01

The sub-band filterbank is one of the most important modules which has the largest amount of calculation in MP3 decoding. In order to save CPU resources and integrate the sub-band filterbank part into MP3 IP core, the hardware circuit of the sub-band filterbank module is designed in this paper. A fast algorithm suit for hardware implementation is proposed and achieved on FPGA development board. The results show that the sub-band filterbank function is correct in the case of using very few registers and the amount of calculation and ROM resources are reduced greatly.
KSC-02pd0757

NASA Image and Video Library

2002-05-24

KENNEDY SPACE CENTER, FLA. -- Dressed in bunny suits, STS-107 Payload Commander Michael Anderson (left) and 107 Payload Specialist Ilan Ramon (right), who is with the Israeli Space Agency, review data in Columbia's payload bay for the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) experiments for the mission. FREESTAR comprises Mediterranean Israeli Dust, Solar Constant, Shuttle Ozone Limb Sounding, Critical Viscosity of Xenon, Low Power, and Space Experimental Module experiments. Another payload is the SHI Research Double Module (SHI/RDM), also known as SPACEHAB. The experiments range from material sciences to life sciences. STS-107 is scheduled to launch July 11, 2002

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